FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Karikari, AS Williams, SR Heisey, CL Rawlett, AM Long, TE AF Karikari, Afia S. Williams, Sharlene R. Heisey, Cheryl L. Rawlett, Adam M. Long, Timothy E. TI Porous thin films based on photo-cross-linked star-shaped poly(D, L-lactide)s SO LANGMUIR LA English DT Article ID SELF-ORGANIZED HONEYCOMB; BREATH-FIGURE METHOD; POLYMER-FILMS; BLOCK-COPOLYMERS; POLY(ETHYLENE GLYCOL); DIBLOCK COPOLYMERS; SOFT LITHOGRAPHY; BUBBLE ARRAYS; FABRICATION; SURFACES AB Self-assembly processes and subsequent photo-cross-linking were used to generate cross-linked, ordered microporous structures on the surfaces of well defined four-arm star-shaped poly(D, L-lactide) (PDLLA) thin films. The four-arm star-shaped PDLLAs were synthesized using an ethoxylated pentaerythritol initiator. Solutions of the PDLLAs were cast in a humid environment, and upon solvent evaporation, ordered honeycomb structures ( or breath figures) were obtained. Correlations between molar mass, polymer solution viscosity, and pore dimensions were established. The average pore dimension decreased with increasing polymer solution concentration, and a linear relationship was observed between relative humidity and average pore dimensions. Highly ordered microporous structures were also developed on four-arm star-shaped methacrylate-modified PDLLA (PDLLA-UM) thin films. Subsequent photocross-linking resulted in more stable PDLLA porous films. The photo-cross-linked films were insoluble, and the honeycomb structures were retained despite solvent exposure. Free-standing, structured PDLLA-UM thin films were obtained upon drying for 24 h. Ordered microporous films based on biocompatible and biodegradable polymers, such as PDLLA, offer potential applications in biosensing and biomedical applications. C1 Virginia Polytech Inst & State Univ, Macromol & Interfaces Inst, Dept Chem, Blacksburg, VA 24061 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Long, TE (reprint author), Virginia Polytech Inst & State Univ, Macromol & Interfaces Inst, Dept Chem, Blacksburg, VA 24061 USA. EM telong@vt.edu NR 53 TC 50 Z9 51 U1 4 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD NOV 7 PY 2006 VL 22 IS 23 BP 9687 EP 9693 DI 10.1021/la0603020 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 100LE UT WOS:000241669800036 PM 17073498 ER PT J AU Severns, PM AF Severns, Paul M. TI Seasonality, habitat preference and life history of some Willamette Valley wet prairie terrestrial molluscs in western Oregon, USA SO VELIGER LA English DT Article ID NORTH-AMERICA; PULMONATA; GASTROPODS; RANGE; WASHINGTON; MOUNTAINS; ARIONIDAE; BEHAVIOR; COMPLEX AB Willamette Valley wet prairie of western Oregon, USA is a seasonally inundated habitat that currently exists in small, highly fragmented reserves. Permanent traps in one wet prairie parcel were repeatedly sampled every five to ten days over three years in order to describe the terrestrial mollusc community. Ten species comprised the community: three exotic slugs (Arion ater s.1., Arion hortensis s.1., Deroceras reticulatum), five native snails (Catinella rehderi, Cochlichopa lubrica, Monadenia fidelis, Vertigo modesta, Verpericola cf. depressa), and two native slugs (Deroceras laeve, Prophysaon andersoni). The wet prairie mollusc community became more active with increased precipitation, with the snails having a longer active season than the Slugs. There were also differences among species in the habitat they were trapped in (wet vs. dry) and the time of year they were sampled, indicating that the environment partially structures the terrestrial mollusc community. The presence of standing water in the wet prairie likely explained why many of the native species actively foraged diurnally under sunny conditions and the overlap of generations in reportedly "annual" species. The unique seasonal flooding of the wet prairie is a harsh condition for terrestrial mollusc existence and the habitat should be investigated further for new species and adaptive mollusc behaviors. C1 USA, Willamette Valley Projects, Lowell, OR 97452 USA. RP Severns, PM (reprint author), Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA. EM severnsp@science.oregonstate.edu NR 36 TC 7 Z9 8 U1 2 U2 20 PU CALIF MALACOZOOLOGICAL SOC INC PI SANTA BARBARA PA SANTA BARBARA MUSEUM NATURAL HISTORY, 2559 PUESTA DEL SOL RD, SANTA BARBARA, CA 93105 USA SN 0042-3211 J9 VELIGER JI Veliger PD NOV 2 PY 2006 VL 48 IS 3 BP 220 EP 227 PG 8 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA 104ET UT WOS:000241940000009 ER PT J AU Tadmor, B McManus, J Koenig, KL AF Tadmor, Boaz McManus, John Koenig, Kristi L. TI The art and science of surge: Experience from Israel and the US military SO ACADEMIC EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Academic Emergency Medicine Consensus Conference on Establishing the Science of Surge CY MAY 17, 2006 CL San Francisco, CA DE disaster; surge; Israel; combat; US military AB In a disaster or mass casualty incident, health care resources may be exceeded and systems may be challenged by unusual requirements. These resources may include pharmaceuticals, supplies, and equipment as well as certain types of academic and administrative expertise. New agencies and decision makers may need to work together in an unfamiliar environment. Furthermore, large numbers of casualties needing treatment, newer therapies required to care for these casualties, and increased workforce and space available for these casualties all contribute to what is often referred to as "surge." Surge capacity in emergency care can be described in technical, scientific terms that are measured by numbers and benchmarks (e.g., beds, patients, and medications) or can take on a more conceptual and abstract form (e.g., decisions, authority, and responsibility). The former may be referred to as the "science" of surge, whereas the latter, an equal if not more important component of surge systems that is more conceptual and abstract, can be considered the "art" of surge. The experiences from Israel and the U.S. military may serve to educate colleagues who may be required to respond or react to an event that taxes the current health care system. This report presents concrete examples of surge capacity strategies used by both Israel and the U.S. military and provides solutions that may be applied to other health care systems when faced with similar situations. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Israel Def Forces, Home Front Command, Dept Med, Hod Hasharon, Israel. Univ Calif Irvine, Sch Med, Dept Emergency Med, Orange, CA 92668 USA. RP McManus, J (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 9 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2006 VL 13 IS 11 BP 1130 EP 1134 DI 10.1197/j.aem.2006.06.043 PG 5 WC Emergency Medicine SC Emergency Medicine GA 104SD UT WOS:000241978400010 PM 17015414 ER PT J AU McManus, J Huebner, K Scheulen, J AF McManus, John Huebner, Kermit Scheulen, James TI The science of surge: Detection and situational awareness SO ACADEMIC EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Academic Emergency Medicine Consensus Conference on Establishing the Science of Surge CY MAY 17, 2006 CL San Francisco, CA DE surge capacity; emergency medicine ID BIOTERRORISM AB As part of the broader "science of surge" consensus initiative sponsored by Academic Emergency Medicine, this report addresses the issues of detection and situational awareness as they relate to surge in the practice of emergency medicine. The purpose of this report, and the breakout group that contributed to its content, was to provide emergency physicians and other stakeholders in the emergency medicine community a sense of direction as they plan, prepare for, and respond to surge in their practice. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. USA, Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. Johns Hopkins Univ, Sch Med, Dept Emergency Med, Baltimore, MD USA. RP McManus, J (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 11 TC 9 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2006 VL 13 IS 11 BP 1179 EP 1182 DI 10.1197/j.aem.2006.06.038 PG 4 WC Emergency Medicine SC Emergency Medicine GA 104SD UT WOS:000241978400020 PM 16968687 ER PT J AU Wilson, DK Collier, SL Ostashev, VE Aldridge, DF Symon, NP Marlin, DH AF Wilson, D. Keith Collier, Sandra L. Ostashev, Vladimir E. Aldridge, David F. Symon, Neill P. Marlin, David H. TI Time-domain modeling of the acoustic impedance of porous surfaces SO ACTA ACUSTICA UNITED WITH ACUSTICA LA English DT Article ID SOUND-PROPAGATION; FINITE-DIFFERENCE; GROUND SURFACES; MEDIA; SIMULATION; REFLECTION; TORTUOSITY; EQUATIONS; BOUNDARY AB A time-domain boundary condition (TDBC) for acoustic reflections from a rigid-frame porous material is derived. The TDBC is the time-domain counterpart of the familiar, linear, frequency-dependent surface impedance for locally reacting surfaces. Although the TDBC is developed from a rather simple, two-parameter phenomenological model, it is shown to apply to a broad range of frequencies and to agree closely with predictions from more sophisticated models that do not have readily derivable time-domain formulas. The TDBC gives the pressure as the sum of two terms involving the particle velocity normal to the surface of the material: one term is directly proportional to the particle velocity at the present time, whereas the other involves a convolution of the particle velocity with a slowly decaying response function. Numerical implementation of the TDBC is discussed and illustrated with example finite-difference, time-domain calculations involving propagation over a porous ground surface. C1 USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. USA, Res Lab, Adelphi, MD 20783 USA. Earth Syst Res Labs, Boulder, CO 80305 USA. New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. Sandia Natl Labs, Albuquerque, NM 87185 USA. USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Wilson, DK (reprint author), USA, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 26 TC 15 Z9 15 U1 0 U2 6 PU S HIRZEL VERLAG PI STUTTGART PA POSTFACH 10 10 61, D-70 009 STUTTGART, GERMANY SN 1610-1928 J9 ACTA ACUST UNITED AC JI Acta Acust. United Acust. PD NOV-DEC PY 2006 VL 92 IS 6 BP 965 EP 975 PG 11 WC Acoustics SC Acoustics GA 139EQ UT WOS:000244415500016 ER PT J AU Mlambo, G Mutambu, SL Mduluza, T Soko, W Mbedzi, J Chivenga, J Lanar, DE Singh, S Carucci, D Gemperli, A Kumar, N AF Mlambo, Godfree Mutambu, Susan L. Mduluza, Takafira Soko, White Mbedzi, Joel Chivenga, James Lanar, David E. Singh, Sanjay Carucci, Daniel Gemperli, Armin Kumar, Nirbhay TI Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude SO ACTA TROPICA LA English DT Article DE P. falciparum; antibody responses; malaria vaccine; transmission; Zimbabwe ID MEROZOITE SURFACE PROTEIN-1; APICAL MEMBRANE ANTIGEN-1; NEW-GUINEAN CHILDREN; BLOOD-STAGE VACCINE; INHIBITORY ANTIBODIES; MALARIA TRANSMISSION; CLINICAL MALARIA; IN-VITRO; PROTECTION; IMMUNOGENICITY AB Antibody levels against malaria antigens were measured among patients presenting with uncomplicated malaria at health centers from three locations in Zimbabwe (Bindura, Chiredzi and Kariba) that are distinct with regard to altitude and climatic conditions. Antibody levels were determined by ELISA using the antigens, apical membrane antigen 1 (AMA-1), erythrocyte binding antigen 175 (EBA-175), circumsporozoite surface protein (CSP), merozoite surface protein 1 (MSP-1) and Pfg27. For all the antigens tested, IgG and IgM levels were higher for Bindura (altitude 1100 m) compared to Kariba (< 600 m, altitude) and Chiredzi (similar to 600 m, altitude) with the exception of IgG and IgM to AMA-1 and EBA-175 which were similar between Chiredzi and Bindura. Plasma samples were further analyzed for their functional activity by testing their ability to inhibit the growth of Plasmodium falciparum in culture. Our results, determined by microscopy and verified by the LDH assay revealed that plasma from the three locations had similar inhibitory activity against the growth of P falciparum in vitro. Our data revealed that highest growth inhibition correlated with the highest levels of MSP-1 antibody values. (c) 2006 Published by Elsevier B.V.. C1 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Malaria Res Inst, Baltimore, MD 21205 USA. Natl Inst Hlth Res, Harare, Zimbabwe. Univ Zimbabwe, Dept Biochem, Harare, Zimbabwe. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NIAD, Malaria Vaccine Dev Unit, NIH, Bethesda, MD USA. USN, Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA. RP Kumar, N (reprint author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Malaria Res Inst, 615 N Wolfe St, Baltimore, MD 21205 USA. EM nkumar@jhsph.edu RI Lanar, David/B-3560-2011 FU FIC NIH HHS [TW001587]; NCRR NIH HHS [RR00052] NR 42 TC 13 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X J9 ACTA TROP JI Acta Trop. PD NOV PY 2006 VL 100 IS 1-2 BP 70 EP 78 DI 10.1016/j.actatropica.2006.09.012 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 126GR UT WOS:000243501200009 PM 17113021 ER PT J AU Kutschej, K Mitterer, C Mulligan, CP Gall, D AF Kutschej, Kerstin Mitterer, Christian Mulligan, Christopher P. Gall, Daniel TI High-temperature tribological behavior of Cr ' N-Ag self-lubricating coatings SO ADVANCED ENGINEERING MATERIALS LA English DT Article ID YTTRIA-STABILIZED ZIRCONIA; LOW-FRICTION CONCEPT; MECHANICAL-PROPERTIES; N COATINGS; MAGNETRON; MICROSTRUCTURE; CRN; DEPOSITION; GROWTH; FILMS C1 Univ Min & Met Leoben, Dept Phys Met & Mat Testing, A-8700 Leoben, Austria. USA, Armament Res & Dev Ctr, Benet Labs, Watervliet, NY 12189 USA. Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. RP Kutschej, K (reprint author), Univ Min & Met Leoben, Dept Phys Met & Mat Testing, Franz Josef Str 18, A-8700 Leoben, Austria. EM kutschey@unileoben.ac.de RI Gall, Daniel/B-1060-2008; Chladil, Kerstin/A-7246-2013; Mitterer, Christian/B-4491-2010 OI Gall, Daniel/0000-0002-5762-9307; Mitterer, Christian/0000-0002-7768-7926 NR 24 TC 44 Z9 46 U1 4 U2 17 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1438-1656 J9 ADV ENG MATER JI Adv. Eng. Mater. PD NOV PY 2006 VL 8 IS 11 BP 1125 EP 1129 DI 10.1002/adem.200600131 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 120DC UT WOS:000243062900016 ER PT J AU Yoon, IK Martin, BL Carr, WW AF Yoon, In-Kyu Martin, Bryan L. Carr, Warner W. CA Immunotherapy Comm Amer Academy TI A comparison of two single-headed and two multi-headed allergen skin test devices SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article ID DUOTIP-TEST; PRICK; PERFORMANCE AB Given the potential differences in performance of skin test devices, the purpose of this study was to prospectively assess the performance of two single-headed and two multiheaded devices for allergy skin testing in terms of wheal size, sensitivity, specificity, intradevice variability, and pain level. Two single-headed devices (Greer Pick, Duotip-Test) and two multiheaded devices (Multi-Test II, OMNI) were tested in 15 subjects in a prospective partially blind fashion looking at wheal reactions and pain using histamine and glycerol-saline on the arms and back. Differences among devices in wheal size and pain were noted. Sensitivity, specificity, and intradevice variability were calculated. Differences between corner and interior heads in multiheaded devices were analyzed. No significant differences were observed in wheal size between Greer Pick (7.1 +/- 1.4 mm) and Duotip-Test (7.2 +/- 1.6 mm). Multiheaded devices were significantly different in wheal size compared with each other and to the single-headed devices (Multi-Test II, 5.4 +/- 1.7 mm; OMNI, 3.3 +/- 1.2 mm). Single-headed devices were more sensitive (100% each, 95% CI of 921-100%) than the multiheaded devices. Multi-Test 11 was significantly more sensitive (83%, 95% CI of 78-87%) than OMNI (57%, 95% CI of 51-62%). There was significant intradevice variability for the multiheaded devices with corner heads being significantly more sensitive than interior heads. Specificities for all devices were equally good (>= 97%). Pain was greater for multiheaded devices than single-headed devices but was generally mild. In conclusion, this study supports the idea that single-headed devices may be more sensitive and consistent than multiheaded devices. Multi-Test II is more sensitive than OMNI. In multiheaded devices, corner heads are more sensitive than interior heads. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Yoon, IK (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. NR 11 TC 4 Z9 4 U1 0 U2 1 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD NOV-DEC PY 2006 VL 27 IS 6 BP 473 EP 478 DI 10.2500/aap.2006.27.2937 PG 6 WC Allergy SC Allergy GA 107UE UT WOS:000242195700008 PM 17176781 ER PT J AU Kastner, WH AF Kastner, William H. TI The quietest war? (Kevin Baker on the Iraq War, Korean War) SO AMERICAN HERITAGE LA English DT Letter C1 USA, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HERITAGE SUBSCRIPTION DEPT PI NEW YORK PA FORBES BUILDING 60 FIFTH AVE, NEW YORK, NY 10011 USA SN 0002-8738 J9 AM HERITAGE JI Am. Herit. PD NOV-DEC PY 2006 VL 57 IS 6 BP 4 EP 4 PG 1 WC History SC History GA 114CV UT WOS:000242645200002 ER PT J AU Hudson, TL Dukes, SF Reilly, K AF Hudson, Timothy L. Dukes, Susan F. Reilly, Karen TI Use of local anesthesia for arterial punctures SO AMERICAN JOURNAL OF CRITICAL CARE LA English DT Article AB BACKGROUND Except for intravenous therapy, arterial access is the most common invasive procedure performed on critically ill patients. Arterial puncture is a source of pain and discomfort. Intradermal injection of lidocaine around the puncture site decreases the incidence and severity of localized pain when used before arterial puncture. OBJECTIVE To review the recommendations and studies related to the use of intradermal lidocaine to decrease pain during arterial punctures.. METHODS Articles were identified by doing a systematic computerized search of MEDLINE (1980 to January 2006) to evaluate articles and reference lists of articles and a manual search of the references listed in original and review articles. English-language articles that evaluated any aspect of pain related to arterial puncture and cannulation, pain related to and methods of introducing lidocaine subcutaneously, and perceptions and use of local anesthesia for arterial or intravenous punctures were reviewed. RESULTS Except among anesthesia providers, the use of a local anesthetic before arterial puncture is not universal, contrary to the standard of practice. A number of false perceptions may prevent wider use of such anesthetics.. CONCLUSION Before a plan for behavior modification or policy change is recommended for use of local anesthesia to decrease pain associated with arterial puncture, further research must be done to determine nurses' perceptions of use, actual practice, and currently established local policies. C1 USA, Ft Bragg, NC 28307 USA. USAF, Washington, DC 20330 USA. USN, Portsmouth, VA USA. RP Hudson, TL (reprint author), USA, Ft Bragg, NC 28307 USA. EM timothy.hudson@us.army.mil NR 33 TC 8 Z9 9 U1 1 U2 3 PU AMER ASSOC CRITICAL CARE NURSES PI ALISO VIEJO PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA SN 1062-3264 J9 AM J CRIT CARE JI Am. J. Crit. Care PD NOV PY 2006 VL 15 IS 6 BP 595 EP 599 PG 5 WC Critical Care Medicine; Nursing SC General & Internal Medicine; Nursing GA V44BU UT WOS:000202979000009 PM 17053266 ER PT J AU Bottoni, CR Smith, EL Berkowitz, MJ Towle, RB Moore, JH AF Bottoni, Craig R. Smith, Eric L. Berkowitz, Mark J. Towle, Robert B. Moore, Josef H. TI Arthroscopic versus open shoulder stabilization for recurrent anterior instability - A prospective randomized clinical trial SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT 31st Annual Meeting of the American-Orthopaedic-Society-for-Sports-Medicine (AOSSM) CY JUL 14-17, 2005 CL Keystone, CO SP Amer Orthopaed Soc Sports Med DE shoulder; anterior instability; arthroscopic; open; Bankart ID BANKART REPAIR; MR ARTHROGRAPHY; END-RESULT; FOLLOW-UP; RECONSTRUCTION; DISLOCATIONS; POSTERIOR; COMPLEX; SURGERY; LESIONS AB Background: Arthroscopic stabilization for anterior shoulder instability has been reported to result in a higher rate of recurrent instability compared to traditional open techniques. Purpose: To test the null hypothesis that there is no difference in the clinical outcomes in patients with recurrent anterior shoulder instability treated with open or arthroscopic stabilization. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A consecutive series of 64 patients with recurrent anterior shoulder instability were randomized to receive either arthroscopic or open stabilization by a single surgeon. Magnetic resonance arthrogram studies were obtained preoperatively. These findings were compared,to arthroscopic findings. Postoperative evaluations included range of motion, stability, and subjective assessments including Single Assessment Numeric Evaluation, Simple Shoulder Test, Western Ontario Instability Index, and University of California, Los Angeles evaluation. Failure was defined as a second dislocation, recurrent subluxation, or symptoms precluding return to previous work or unrestricted active military duty. Results: Sixty-one patients, 29 who received open stabilization and 32 who received arthroscopic stabilization, were evaluated at a mean of 32 months postoperatively (range, 24-48 months). Patient demographics were equivalent. Preoperative magnetic resonance arthrogram findings were confirmed at arthroscopic examination. The mean operative time was significantly shorter for the arthroscopic repairs (59 vs 149 minutes; P <.001). There were 3 clinical failures (2 open stabilizations, 1 arthroscopic stabilization) by the established criteria. There was a statistically significant improvement from preoperative to postoperative Single Assessment Numeric Evaluation scores in both groups (P <.001). The mean loss of motion (compared to the contralateral shoulder) was greater in the open shoulders. Subjective evaluations were equal in both groups. Conclusion: Clinical outcomes after arthroscopic and open stabilization were comparable. Preoperative magnetic resonance arthrograms in shoulders with anterior instability allow an accurate diagnosis of intra-articular abnormality that correlates well with operative findings. Arthroscopic stabilization for recurrent anterior shoulder instability can be performed safely; the clinical outcomes are comparable to those after traditional open stabilization. C1 Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. RP Bottoni, CR (reprint author), OrthoSports, 3251 McMullen,Booth Rd, Clearwater, FL 33671 USA. EM CRBottoni@yahoo.com NR 39 TC 96 Z9 98 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2006 VL 34 IS 11 BP 1730 EP 1737 DI 10.1177/0363546506288239 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 103WB UT WOS:000241916800002 PM 16735589 ER PT J AU Zollner, GE Putnam, JL Richardson, JH Hoel, D Hanafi, HA Coleman, RE AF Zollner, Gabriela E. Putnam, John L. Richardson, Jason H. Hoel, David Hanafi, Hanafi A. Coleman, Russell E. TI Evaluation of novel long-lasting, insecticide-impregnated materials to control adult sand flies in Iraq, Kenya and Egypt SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Air Force Inst Operat Hlth, San Antonio, TX USA. US Army Med Res Unit, Nairobi, Kenya. US Naval Med Res Unit No 3, Cairo, Egypt. RI Zollner, Gabriela/B-6073-2011; Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 7 BP 2 EP 2 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900008 ER PT J AU Venkatesan, M Claire Hauer, M Westbrook, CJ Rasgon, JL AF Venkatesan, Meera Claire Hauer, M. Westbrook, Catherine J. Rasgon, Jason L. TI Genetic linkage mapping and evidence of population expansion in the West Nile Virus vector Culex tarsalis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 19 BP 6 EP 6 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900020 ER PT J AU Parker, TM Ismail, T Fadeel, MA Maksoud, MA Morcos, M Newire, E Wasfy, MO Murray, CK Pimentel, G El-Sayed, N Hajjeh, R AF Parker, Tina M. Ismail, Tharwat Fadeel, Moustafa A. Maksoud, Mohamed Abdel Morcos, Myriam Newire, Enas Wasfy, Momtaz O. Murray, Clinton K. Pimentel, Guillermo El-Sayed, Nasr Hajjeh, Rana TI Laboratory-based surveillance for acute febrile illness in Egypt: A focus on leptospirosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USN, Med Res Unit 3, Cairo, Egypt. USA, Brooke Army Med Ctr, Houston, TX USA. Minist Hlth & Populat, Cairo, Egypt. Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 60 BP 18 EP 18 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900061 ER PT J AU Si, YZ Li, QG Haeberle, AS Milhous, WK Weina, PJ AF Si, Yuanzheng Li, Qigui Haeberle, Adam S. Milhous, Wilbur K. Weina, Peter J. TI [14C]artesunate tissue distribution in pregnant rats following a single intravenous dose with whole-body autoradiography SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 61 BP 18 EP 19 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900062 ER PT J AU Petras, JM AF Petras, J. M. TI Comparative neuropathology of the artemesinin compounds arteether, artemether, artelinate, and artesunate in Rattus norvegicus. I. cytopathology of the auditory nuclei SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 76 BP 23 EP 23 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900077 ER PT J AU Jongsakul, K Chaisawang, C Bunrasri, C Buathong, N Hanwisai, S Teopipithaporn, S Wimonwattrawatee, T Ur-Kowitchai, C Noedl, H Coldren, R Fukuda, M AF Jongsakul, Krisada Chaisawang, Chaisombat Bunrasri, Chalerm Buathong, Nillawan Hanwisai, Suthatta Teopipithaporn, Suriya Wimonwattrawatee, Theera Ur-Kowitchai, Charn Noedl, Harald Coldren, Rodney Fukuda, Mark TI Malaria situation: Risk and control in tsunami-affected areas, Phang Nga Province, Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Bangkok, Thailand. Off Dis Prevent & Control Reg 11, Nakom Srithammarat, Thailand. Vector Borne Dis Control Ctr 111, Phang Nga, Thailand. Armed Forces Res Inst Med Sci, Global Emerging Inf Dis Surveillance Program, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 87 BP 26 EP 27 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900088 ER PT J AU Stromdahl, EY Evans, SR Barry, RK Cai, C Vince, MA Williamson, PC AF Stromdahl, Ellen Y. Evans, Sandra R. Barry, Ryan K. Cai, Cindy Vince, Mary A. Williamson, Phillip C. TI Prevalence of Borrelia burgdorferi, bartonella spp., Babesia microti, and Anaplasma phagocytophilum in Ixodes scapularis ticks removed from humans SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. Univ N Texas, Ctr Hearing Sci, Ft Worth, TX USA. NR 0 TC 0 Z9 0 U1 3 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 97 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900098 ER PT J AU Sanchez, JL Bautista, CT Galvan, R Lama, JR Singer, DM Malia, JA Laguna-Torress, VA Montano, SM Guthrie, BL Carr, JK Celum, CL Sanchez, JL AF Sanchez, Jose L. Bautista, Christian T. Galvan, Rosa Lama, Javier R. Singer, Darrell M. Malia, Jennifer A. Laguna-Torress, Victor A. Montano, Silvia M. Guthrie, Benjamin L. Carr, Jean K. Celum, Connie L. Sanchez, Jorge L. TI Epidemiology of hepatitis c virus infection and association with human immunodeficiency virus among men who have sex with men in lima, Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Anteon Corp, Derwood, MD USA. Henry M Jackson Fdn Advancement Mil Med Inc, Rockville, MD USA. Assoc Civil Impacta Salud & Educ, Lima, Peru. Walter Reed Army Inst Res, Silver Spring, MD USA. USN, Med Res Ctr Detachment, Lima, Peru. USN, Med Res Ctr Detachment, Silver Spring, MD USA. Anteon Corp, Frederick, MD USA. Inst Human Virol, Baltimore, MD USA. Univ Washington, Seattle, WA 98195 USA. RI Bautista, Christian/B-2812-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 133 BP 39 EP 39 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900134 ER PT J AU Yoon, IK Zhou, Y Cox, JH Lukes, Y Reinhardt, B Wortmann, G AF Yoon, In-Kyu Zhou, Yaling Cox, Josephine H. Lukes, Yvonne Reinhardt, Brian Wortmann, Glenn TI Lymphocyte subsets before and after sodium stibogluconate treatment SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 146 BP 43 EP 43 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900147 ER PT J AU Li, Q Milhous, W Weina, P AF Li, Qigui Milhous, Wilbur Weina, Peter TI Relationship between the neurotoxicity and pharmacokinetic profiles of artemisinin derivatives in animal species SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 167 BP 49 EP 50 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900168 ER PT J AU Ubalee, R Ruangareerate, T Trongnipatt, N Yimamnuaychoke, N Sattabongkot, J AF Ubalee, Ratawan Ruangareerate, Toon Trongnipatt, Namtip Yimamnuaychoke, Nongnuch Sattabongkot, Jetsumon TI Optimization of a hepatocyte culture system for in vitro screening of compounds against liver stages of P-falciparum and P-vivax SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 164 BP 49 EP 49 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900165 ER PT J AU Xie, LH Li, Q Johnson, J Zhang, J Milhous, W Kyle, D AF Xie, Lisa H. Li, Qigui Johnson, Jacob Zhang, Jing Milhous, Wilbur Kyle, Dennis TI Flow cytometry assay for counting parasitemia in rodent blood: Development process and validation SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 174 BP 52 EP 52 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900175 ER PT J AU Bennett, KS Si, Y Steinbach, T Zhang, J Li, Q AF Bennett, Kent S. Si, Yuanzheng Steinbach, Thomas Zhang, Jing Li, Qigui TI Tolerability of IM artesunate SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Navy Res Ctr, Silver Spring, MD USA. RI Bennett, Kent/K-2742-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 179 BP 53 EP 53 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900180 ER PT J AU Li, Q Xie, L Haeberle, A Zhang, J Weina, P AF Li, Qigui Xie, Lisa Haeberle, Adam Zhang, Jing Weina, Peter TI Pharmacokinetics and bioequivalence of two formulations of artesunate following single and multiple intravenous injections in rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 178 BP 53 EP 53 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900179 ER PT J AU Gutteridge, CE Hoffman, MM Bhattacharjee, AK AF Gutteridge, Clare E. Hoffman, Marshall M. Bhattacharjee, Apurba K. TI Antimalarial activity of substituted 1,7-diaminoisoquinolines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USN Acad, Annapolis, MD 21402 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 184 BP 54 EP 54 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900185 ER PT J AU Kung'u, A Waitumbi, J Ogutu, B Withers, M Ghai, M Grills, A Ockenhouse, C AF Kung'u, Amos Waitumbi, John Ogutu, Bernhards Withers, Mark Ghai, Mala Grills, Ardath Ockenhouse, Christian TI MSP-1(19) haplotype diversity of malaria parasites in children vaccinated with a MSP-1(42) malaria vaccine in Western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Nairobi, Nairobi, Kenya. Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 215 BP 64 EP 64 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900216 ER PT J AU Pichyangkul, S Engering, AJ Ketloy, C Limsalakpetch, A Kum-Arb, U Yongvanitchit, K Ruxrungtham, K Heppner, DG Fukuda, MM AF Pichyangkul, Sathit Engering, Anneke J. Ketloy, Chutitorn Limsalakpetch, Amporn Kum-Arb, Utaiwan Yongvanitchit, Kosol Ruxrungtham, Kiat Heppner, D. Gray Fukuda, Mark M. TI Expression and function of toll-like receptors on dendritic cells from rhesus macaques SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Chulalongkorn Univ, Bangkok, Thailand. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 218 BP 65 EP 65 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900219 ER PT J AU Conn, JE Li, C Povoa, MM Wilkerson, RC AF Conn, Jan E. Li, Cong Povoa, Marinete M. Wilkerson, Richard C. TI Genetic population structure in the malaria vector Anopheles marajoara in Northeastern South America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Wadsworth Ctr, NYSDOH, Slingerlands, NY USA. Walter Reed Army Inst Res, Suitland, MD USA. Inst Evandro Chagas, Belem, Para, Brazil. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 238 BP 70 EP 70 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900239 ER PT J AU Koenraadt, CJ Aldstadt, J Kijchalao, U Kengluecha, A Jones, JW Scott, TW AF Koenraadt, Constantianus J. Aldstadt, Jared Kijchalao, Udom Kengluecha, Ampornpan Jones, James W. Scott, Thomas W. TI Spatial and temporal patterns in the recovery of Aedes aegypti populations after insecticide treatment SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Calif Ithaca, Ithaca, NY USA. San Diego State Univ, San Diego, CA 92182 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 245 BP 72 EP 72 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900246 ER PT J AU Facchinelli, L Koenraadt, CJ Kijchalao, U Valerio, L Jones, JW Scott, TW della Torre, A AF Facchinelli, Luca Koenraadt, Constantianus J. Kijchalao, Udom Valerio, Laura Jones, James W. Scott, Thomas W. della Torre, Alessandra TI Testing the efficacy of a novel sticky trap in collecting Aedes adults in a dengue-endemic area in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Roma La Sapienza, Dept Publ Hlth Sci, Parasitol Unit, Rome, Italy. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 256 BP 75 EP 75 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900257 ER PT J AU He, JK Vaughn, DW Dewar, V Voet, P AF He, Junkun Vaughn, David W. Dewar, Vincent Voet, Pierre TI Characterization of monoclonal antibodies to hepatitis E virus (HEV) capsid protein and identification of their binding and neutralization activities SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Inst Pathol, Rockville, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 274 BP 79 EP 80 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900275 ER PT J AU Fair, JN Branco, L Sampey, D Matschiner, A Monagin, C Cashman, K Ferro, P Goba, A Bausch, D Wilson, R Garry, R Guttieri, M AF Fair, Joseph N. Branco, Luis Sampey, Darryl Matschiner, Alex Monagin, Corina Cashman, Kathleen Ferro, Philip Goba, Augustin Bausch, Daniel Wilson, Russell Garry, Robert Guttieri, Mary TI Development and characterization of recombinant arenavirus proteins and virus-specific monoclonal antibodies for use in diagnostic and therapeutic applications: An integrated approach to public health and biodefense SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Tulane Univ, Ft Detrick, MD USA. Biofactura Inc, Rockville, MD USA. Tulane Univ, New Orleans, LA 70118 USA. US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. Kenema Gov Hosp, Lassa Fever Lab, Kenema, Sierra Leone. Autoimmun Technol Inc, New Orleans, LA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 277 BP 80 EP 81 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900278 ER PT J AU Asher, LV Wahl-Jensen, V Zimmerman, M Larsen, T Hooper, JW AF Asher, Ludmila V. Wahl-Jensen, Victoria Zimmerman, Michael Larsen, Tom Hooper, Jay W. TI Ultrastructural pathology of the lungs of Syrian hamsters infected with Andes virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 US Army Med Res Inst Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 284 BP 82 EP 83 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900285 ER PT J AU Coldren, RL Ofula, VO Onyango, C Adungo, N Mbui, J AF Coldren, Rodney L. Ofula, Victor O. Onyango, Clayton Adungo, Nicholas Mbui, Jane TI Prevalence of IgG against selected arboviruses among patients admitted with febrile illnesses at three hospitals in Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. US Army Med Res Unit, Nairobi, Kenya. KEMRI Ctr Infect Parasit Dis, Busia, Kenya. KEMRI Ctr Clin Res, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 285 BP 83 EP 83 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900286 ER PT J AU Khodiev, AV Ibadova, GA Phasuk, R Nakjarung, K Bodhidatta, L AF Khodiev, Aybek V. Ibadova, Gulnara A. Phasuk, R. Nakjarung, K. Bodhidatta, L. TI Efficacy of DNA extraction and real time PCR for detection of plasmid ipaH of Shigella spp. in unidentified lyophilized stool samples SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 SRIEMID, Tashkent, Uzbekistan. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 286 BP 83 EP 83 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900287 ER PT J AU Lanteri, CA Heady, TN Bhattacharjee, AK Cabezas, M Caridha, D Gerena, L Gettayacamin, M Obaldia, N Roncal, N Shearer, T Smith, PL Tungtaeng, A Yourick, DL Smith, KS Dow, GS AF Lanteri, Charlotte A. Heady, Tiffany N. Bhattacharjee, Apurba K. Cabezas, Miriam Caridha, Diana Gerena, Lucia Gettayacamin, Montip Obaldia, Nicanor Roncal, Norma Shearer, Todd Smith, Philip L. Tungtaeng, Anchalee Yourick, Debra L. Smith, Kirsten S. Dow, Geoffrey S. TI Evaluation of alkylaminoquinolinyl-methanols as new antimalarials SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring 10400, MD USA. Armed Forces Res Inst Med Sci, Bangkok, Thailand. Gorgas Mem Inst, Trop Med Res, Panama City, Panama. RI Yourick, Debra/A-2121-2011; Obaldia, Nicanor/O-8460-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 335 BP 97 EP 97 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900336 ER PT J AU Weina, PJ Miller, RS Cantilena, L Remich, S Haeberle, A Lowe, MC Milhous, WK AF Weina, Peter J. Miller, R. Scott Cantilena, Louis Remich, Shon Haeberle, Adam Lowe, Michael C. Milhous, Wilbur K. TI Update on making cGMP intravenous artesunate available in the United States SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. US Army Med Res Unit, Kisumu, Kenya. RI Weina, Peter/A-2120-2011 NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 338 BP 98 EP 98 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900339 ER PT J AU Jarman, RG Klungthong, C Rodpradit, P Chusak, P Gibbons, RV Koenraadt, S Thammapalo, S Thaisomboonsuk, B Jones, JM Nisalak, A Endy, TP Libraty, DH Ennis, FA Rothman, A Srikiatkhachorn, A Sithisiprasasna, R Green, S Scott, TW Mammen, MP AF Jarman, R. G. Klungthong, C. Rodpradit, P. Chusak, P. Gibbons, R. V. Koenraadt, S. Thammapalo, S. Thaisomboonsuk, B. Jones, J. M. Nisalak, A. Endy, T. P. Libraty, D. H. Ennis, F. A. Rothman, A. Srikiatkhachorn, A. Sithisiprasasna, R. Green, S. Scott, T. W. Mammen, M. P. TI Dengue viral sequence analysis from both human and mosquito samples isolated during cluster investigations in Kamphaeng Phet, Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Univ Calif Davis, Davis, CA 95616 USA. Minist Publ Hlth, Nonthaburi, Thailand. Walter Reed Army Inst Res, Silver Spring, MD USA. Univ Massachusetts, Sch Med, Worcester, MA 01605 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 370 BP 108 EP 108 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900371 ER PT J AU Zhang, CL Chinnawirotpisan, P Klungthong, C Rodpradit, P Thomas, SJ Mammen, MP AF Zhang, Chunlin Chinnawirotpisan, Piyawan Klungthong, Chonticha Rodpradit, Prinyada Thomas, Stephen J. Mammen, Mammen P. TI Comparative analysis reveals genetic differences of dengue viruses isolated from patients during the periods of high, intermediate and low transmission SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 US Army Med & Materiel Command, Military Inf Dis Res Program, Ft Detrick, MD USA. Inst Med Sci, US Army Med Component Armed Force Research, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 371 BP 108 EP 108 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900372 ER PT J AU Noedl, H Jongsakul, K Satimai, W Tongkong, D Sirichaisinthop, J Sriwichai, S Fukuda, M AF Noedl, Harald Jongsakul, Krisada Satimai, Wichai Tongkong, Dokruk Sirichaisinthop, Jeeraphat Sriwichai, Sabaithip Fukuda, Mark TI Artemisinin resistance along the Thai-Cambodian border? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Med Univ Vienna, Vienna, Austria. Inst Med Sci, US Army Med Component Armed Forces Res, Bangkok, Thailand. Off Dis Prevent & Control Reg 3, Chon Buri, Thailand. Vector Borne Dis Control Ctr 34, Trat, Thailand. Off Vector Borne Dis Control, Sara Buri, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 374 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900375 ER PT J AU Solberg, VB Schnupp, CP Chenault, VM AF Solberg, Victoria B. Schnupp, Carol P. Chenault, V. Michelle TI Novel methods for adult and immature sand fly control -- phase I, laboratory trials SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Uniform Serv Hlth Sci, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 395 BP 116 EP 116 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900396 ER PT J AU Griffith, ME Moon, JE Ellis, MW Clark, KP Ressner, RA Hawley, JS Rivard, RG McCall, S Reitstetter, RE Hospenthal, DR Murray, CK AF Griffith, Matthew E. Moon, James E. Ellis, Michael W. Clark, Kyra P. Ressner, Roseanne A. Hawley, Joshua S. Rivard, Robert G. McCall, Suzanne Reitstetter, Raven E. Hospenthal, Duane R. Murray, Clinton K. TI Efficacy of carbepenems in the treatment of a hamster model of acute leptospirosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 405 BP 118 EP 118 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900406 ER PT J AU Fukuda, MM Dass, K Wortmann, G Mitre, E Hochberg, L Lucey, D AF Fukuda, Mark M. Dass, Krisha Wortmann, Glenn Mitre, Ed Hochberg, Lisa Lucey, Daniel TI Mucosal leishmaniasis in a central American immigrant diagnosed with real-time PCR: Case report and review of diagnostic and treatment issues SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Inst Hlth, Bethesda, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 416 BP 121 EP 121 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900417 ER PT J AU Ellis, RD Fukuda, MM Nisalak, A Lerdthusnee, K Murray, CK Insuan, S Mahathat, C McDaniel, P Buathong, N Uthaimongkol, N Sriwichai, S Tulyanon, S Laboonchai, A Krasaesub, S Miller, RS AF Ellis, Ruth D. Fukuda, Mark M. Nisalak, Ananda Lerdthusnee, Kriangkrai Murray, Clinton K. Insuan, Sucheera Mahathat, Chaiyawat McDaniel, Philip Buathong, Nillawan Uthaimongkol, Nichapat Sriwichai, Sabaithip Tulyanon, Somchit Laboonchai, Anintita Krasaesub, Somporn Miller, R. Scott TI Evaluation of Multi-Dip-S-Ticks SDLST in an endemic population on the Thai-Myanmar border SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Rockville, MD USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Brooke Army Med Ctr, Houston, TX USA. Kanchanaburi River Christian Hosp, Sangkhlaburi, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 421 BP 123 EP 123 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900422 ER PT J AU Myint, KS Duriyaphan, P Mammen, MP Rodkwamtook, W Sirisopana, N Gibbons, RV AF Myint, Khin S. Duriyaphan, Pochaman Mammen, Mammen P. Rodkwamtook, Wutikon Sirisopana, Narongrid Gibbons, Robert V. TI Hepatitis E infection in Thai troops deployed with united nations peacekeeping forces SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, US Army Component, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Royal Thai Army, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 445 BP 130 EP 130 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900446 ER PT J AU Nisalak, A Gibbons, RV Jarman, RG Pimgate, C Krungthong, C Thaisomboonsuk, B Mammen, MP Srikiatkhachorn, A AF Nisalak, Ananda Gibbons, Robert V. Jarman, Richard G. Pimgate, Chusak Krungthong, Chonticha Thaisomboonsuk, Butsaya Mammen, P. Mammen Srikiatkhachorn, Anon TI Dengue incidence: A two year continued prospective study of dengue virus transmission and disease in primary school children SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, USA Med Component, Bangkok 10400, Thailand. Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 472 BP 138 EP 138 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900473 ER PT J AU Han, ET Watanabe, R Sattabongkot, J Khuntirat, B Sirichaisinthop, J Takeo, S Tsuboi, T AF Han, Eun-Taek Watanabe, Risa Sattabongkot, Jetsumon Khuntirat, Benjawan Sirichaisinthop, Jeeraphat Takeo, Satoru Tsuboi, Takafumi TI Detection of four Plasmodium species by genus-and species-specific loop-mediated isothermal amplification for clinical malaria patients SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Cell Free Sci Res & Technol Ctr, Matsuyama, Ehime, Japan. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Vector Borne Dis Training Ctr, Sara Buri, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 532 BP 155 EP 155 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900533 ER PT J AU Miller, RS AF Miller, Robert S. TI Comparison of performance characteristics of the binax now (R) malaria test using venous and fingerstick samples SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Potomac, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 533 BP 155 EP 155 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900534 ER PT J AU Gettayacamin, M Sattabongkot, J Hansukjariya, P Tungtaeng, A Kyle, D AF Gettayacamin, Montip Sattabongkot, Jetsumon Hansukjariya, Pranee Tungtaeng, Anchalee Kyle, Dennis TI Development of Anopheles dirus sporozoite-induced mouse malaria model SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 538 BP 156 EP 157 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900539 ER PT J AU Salas, C Magill, A Santolalla, M Lucas, C Bacon, DJ AF Salas, Carola Magill, Alan Santolalla, Meddly Lucas, Carmen Bacon, David J. TI Significant association between the presence of the bolivia repeat insertion in the DHFR gene of Plasmodium falciparum and in vivo resistance to sulfadoxine-pyrimethamine (SP) in isolates collected in the Amazon region of Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Naval Med Res Ctr Detachment, Lima, Peru. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 546 BP 159 EP 159 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343900547 ER PT J AU Yongvanitchit, K Engering, AJ Kum-Arb, U Limsalakpetch, A Fukuda, MM Pichyangkul, S AF Yongvanitchit, Kosol Engering, Anneke J. Kum-Arb, Utaiwan Limsalakpetch, Amporn Fukuda, Mark M. Pichyangkul, Sathit TI Revisiting the interaction of dendritic cells with malaria blood stage parasites SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 566 BP 165 EP 165 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901002 ER PT J AU Wood, CL Robinson, S Ware, L Stewart, VA Angov, E AF Wood, Chloe L. Robinson, Sally Ware, Lisa Stewart, V. Ann Angov, Evelina TI Mouse potency assays for measuring recombinant protein vaccine stability SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 576 BP 167 EP 167 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901011 ER PT J AU Falzarano, D Feldmann, F Martin, S Geisbert, J Grolla, A Fernando, L Stroher, U Ebihara, H Strong, J Jones, S Feldmann, H Geisbert, TW AF Falzarano, Darryl Feldmann, Friederike Martin, Sandra Geisbert, Joan Grolla, Allen Fernando, Lisa Stroher, Ute Ebihara, Hideki Strong, Jim Jones, Steven Feldmann, Heinz Geisbert, Thomas W. TI Characterization of Marburg virus from a recent outbreak in Angola SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Univ Tokyo, Inst Med Sci, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 660 BP 190 EP 190 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901095 ER PT J AU Kuniholm, MH Rossi, CA Mpoudi-Ngole, E Tamoufe, U LeBreton, M Rimoin, AW Bausch, DG Burke, DS Wolfe, ND AF Kuniholm, Mark H. Rossi, Cynthia A. Mpoudi-Ngole, Eitel Tamoufe, Ubald LeBreton, Matthew Rimoin, Anne W. Bausch, Daniel G. Burke, Donald S. Wolfe, Nathan D. TI Consumption of bats is a risk factor for Ebola virus infection among rural Cameroonian adults SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Johns Hopkins Bloomberg, Sch Publ Hlth, Baltimore, MD USA. USA, Med Res Inst Infect Dis, Frederick, MD USA. Army Hlth Res Ctr, Yaounde, Cameroon. Johns Hopkins Cameroon Program, Yaounde, Cameroon. Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA. Tulane Sch Publ Hlth & Tropical Med, New Orleans, LA USA. NR 0 TC 0 Z9 0 U1 2 U2 12 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 659 BP 190 EP 190 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901094 ER PT J AU Turell, MJ Parker, MD AF Turell, Michael J. Parker, Michael D. TI Venezuelan equine encephalitis virus candidate vaccine (V3526) protects hamsters from challenge by both mosquito bite or intraperitoneal injection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Med Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 682 BP 197 EP 197 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901117 ER PT J AU Scott, TW Gerade, B Harrington, LC Jones, JW Edman, JD Kitthawee, S Minnick, SL Clark, JM AF Scott, Thomas W. Gerade, Benjamin Harrington, Laura C. Jones, James W. Edman, John D. Kitthawee, Sangvorn Minnick, Sharon L. Clark, John M. TI Age-structure of Aedes aegypti populations and intra-annual variation in dengue transmission SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Calif Davis, Davis, CA 95616 USA. Univ Massachusetts, Amherst, MA 01003 USA. Cornell Univ, Ithaca, NY USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Mahidol Univ, Bangkok 10700, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 726 BP 210 EP 210 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901161 ER PT J AU Babino, Z Mendez, J Weina, PJ AF Babino, Zachary Mendez, Juan Weina, Peter J. TI Blood agar substitute in growing Leishmania SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 765 BP 221 EP 221 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901200 ER PT J AU Durant, L Mendez, J Weina, P AF Durant, Lisa Mendez, Juan Weina, Peter TI Cross reference between cellulose acetate electrophoresis (CAE) and polymerase chain reaction (PCR) in Leishmania diagnosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 766 BP 221 EP 222 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901201 ER PT J AU Mendez, J Weina, PJ AF Mendez, Juan Weina, Peter J. TI Cellulose acetate electrophoresis (CAE) a vital technique in Leishmania diagnosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 763 BP 221 EP 221 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901198 ER PT J AU Remich, SA Oyugi, M Apollo, D Ohrt, C Ogutu, B Miller, RS AF Remich, Shon A. Oyugi, Mary Apollo, Duncan Ohrt, Colin Ogutu, Bernhards Miller, Robert S. TI The utility of HRP-2/p-LDH malaria rapid diagnostic tests in semi-immune populations of Sub-Sahara Africa SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Med Res Unit, Nairobi, Kenya. Kenya Govt Med Res Ctr, Nairobi, Kenya. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 770 BP 222 EP 222 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901205 ER PT J AU Tally, J Mendez, J Weina, PJ AF Tally, John Mendez, Juan Weina, Peter J. TI College of American pathology (CAP) and its progress in the Leishmania diagnosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 768 BP 222 EP 222 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901203 ER PT J AU Remich, SA Otieno, W Apollo, D Ogutu, B Polhemus, M Miller, RS AF Remich, Shon A. Otieno, Walter Apollo, Duncan Ogutu, Bernhards Polhemus, Mark Miller, Robert S. TI Rapid diagnostic malaria tests for the diagnosis of malaria verses clinical judgment SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Med Res Unit, Nairobi, Kenya. Kenya Govt Med Res Ctr, Nairobi, Kenya. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 773 BP 223 EP 223 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901208 ER PT J AU Remich, SA Polhemus, M Otieno, W Ogutu, B Weina, P Miller, RS AF Remich, Shon A. Polhemus, Mark Otieno, Walter Ogutu, Bernhards Weina, Peter Miller, Robert S. TI A phase II, open label, study of the safety, tolerability, efficacy and pharmacokinetics of intravenous artesunate in adults with uncomplicated malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Med Res Unit, Nairobi, Kenya. Kenya Govt Med Res Ctr, Nairobi, Kenya. Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 775 BP 224 EP 224 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901210 ER PT J AU Koneru, B Putnak, R Anderson, C Thomas, SJ Barvir, D Simmons, M Lynch, J Ting, E Gangemi, D Sun, W AF Koneru, Bhanumati Putnak, Robert Anderson, Curtis Thomas, Stephen J. Barvir, Dave Simmons, Monika Lynch, Julia Ting, Edmund Gangemi, David Sun, Wellington TI Inactivation of dengue virus using high hydrostatic pressure (HHP) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Avure Technol Inc, Kent, OH USA. Naval Med Res Ctr, Silver Spring, MD USA. Clemson Univ, Clemson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 797 BP 230 EP 230 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901232 ER PT J AU Houng, HSH Palmer, D Zhao, B Lynch, J Sun, W AF Houng, Huo-Shu H. Palmer, Dupeh Zhao, Bangti Lynch, Julia Sun, Wellington TI Quasi species of dengue RNA: Molecular dissection of dengue virus infections in monocytes-derived human dendritic cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 801 BP 231 EP 231 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901236 ER PT J AU Ypil-Butac, CA Gibbons, RV Jarman, RG Thaisomboonsuk, B Krungthong, C Mammen, MP AF Ypil-Butac, Charity Ann Gibbons, Robert V. Jarman, Richard G. Thaisomboonsuk, Butsaya Krungthong, Chonticha Mammen, Mammen P. TI Seroepidemiology of hospitalized dengue patients in the Philippines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, US Army Med Component, Cebu, Philippines. Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 803 BP 232 EP 232 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901238 ER PT J AU Durant, L Mendez, J Weina, PJ AF Durant, Lisa Mendez, Juan Weina, Peter J. TI Cross reference between cellulose acetate electrophoresis (CAE) and ploymerase chain reaction (PCR) in Leishmania diagnosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 830 BP 239 EP 239 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901265 ER PT J AU Babino, Z Mendez, J Weina, PJ AF Babino, Zachary Mendez, Juan Weina, Peter J. TI Blood agar substitute in growing leishmania SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 831 BP 240 EP 240 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901266 ER PT J AU Duncan, EH Michael, SE Angov, E Bergmann-Leitner, ES Lyon, JA AF Duncan, Elizabeth H. Michael, Sara E. Angov, Evelina Bergmann-Leitner, Elke S. Lyon, Jeffrey A. TI Characterization of P-falciparum MSP1-specific monoclonal antibodies with regards to reactivity on live parasites, fine specificity, and biological function SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 849 BP 244 EP 244 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901284 ER PT J AU Ruangareerate, T Trongnipatt, N Ubalee, R Kongkasuriyachai, D Sattabongkot, J AF Ruangareerate, Toon Trongnipatt, Namtip Ubalee, Ratawan Kongkasuriyachai, Darin Sattabongkot, Jetsumon TI Development of quantitative real-time PCR as a sensitive and effective approach for detecting Plasmodium-infected HC-04 cell line SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Thai Component, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, US Component, Bangkok 10400, Thailand. RI Kongkasuriyachai, Darin/F-2123-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 861 BP 247 EP 248 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901296 ER PT J AU Waters, NC Gaona, HW Prigge, ST Hudson, TH Reynolds, KA Heady, TN Huddler, DP Kreishman-Deitrick, M Bhattacharjee, AK Gerena, L Roncal, N Lopez-Sanchez, M Lee, P AF Waters, Norman C. Gaona, Heather W. Prigge, Sean T. Hudson, Thomas H. Reynolds, Kevin A. Heady, Tiffany N. Huddler, Donald P. Kreishman-Deitrick, Mara Bhattacharjee, Apurba K. Gerena, Lucia Roncal, Norma Lopez-Sanchez, Miriam Lee, Patricia TI Identification of aromatic sulfonyls as inhibitors of Beta-ketoacyl ACP synthase III (PFKASIII) in Plasmodium falciparum fatty acid synthesis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Johns Hopkins Univ, Baltimore, MD USA. Portland State Univ, Portland, OR 97207 USA. RI Hudson, Thomas/A-9152-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 869 BP 250 EP 250 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901304 ER PT J AU Johnson, JD Dennull, RA Gerena, L Roncal, NE Lopez-Sanchez, M Waters, NC AF Johnson, Jacob D. Dennull, Richard A. Gerena, Lucia Roncal, Norma E. Lopez-Sanchez, Miriam Waters, Norman C. TI Assessment and continued validation of the MSF assay for use in malaria drug screening SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Valle, Ruben/A-7512-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 871 BP 251 EP 251 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901306 ER PT J AU Waters, NC Dennull, R Cortes, E Jirage, D Bhattacharjee, A Prigge, S Gerena, L Lopez-Sanchez, M Roncal, N Caridha, D AF Waters, Norman C. Dennull, Richard Cortes, Edison Jirage, Dayadevi Bhattacharjee, Apurba Prigge, Sean Gerena, Lucia Lopez-Sanchez, Miriam Roncal, Norma Caridha, Diana TI Establishment of thiophene sulfonamides as novel inhibitors of the plasmodial Cyclin Dependent Protein Kinases (CDKs) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Johns Hopkins Univ, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 873 BP 251 EP 251 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901308 ER PT J AU Tamminga, C Chretien, JP Gerena, L Butler, W Milhous, W AF Tamminga, Cindy Chretien, Jean-Paul Gerena, Lucia Butler, William Milhous, Wilbur TI P-falciparum infection among US marines deployed to Liberia: Comparison of mefloquine resistance patterns to archived Liberia isolates and previous studies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 878 BP 252 EP 253 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901313 ER PT J AU Kozyr, N Ayres, J Gan, WN Harkins, T Gu, ZP Charlab, R Li, P Hendrix, R Berg, T Cabrera-Mora, M Akinyi, S Dickherber, M Larsen, C Staprans, S Moreno, A Galinski, MR AF Kozyr, Natalia Ayres, Jennifer Gan, Weiniu Harkins, Timothy Gu, Zhiping Charlab, Rosane Li, Peter Hendrix, Rose Berg, Tiina Cabrera-Mora, Monica Akinyi, Sheila Dickherber, Megan Larsen, Christian Staprans, Silvija Moreno, Alberto Galinski, Mary R. TI Validation and implementation of rhesus immune profiling gene expression assays in non-human primate models of malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Maryland, Baltimore, MD 21201 USA. Univ Bamako, Bamako, Mali. Walter Reed Army Inst Res, Silver Spring, MD USA. GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 891 BP 257 EP 257 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901326 ER PT J AU Lyke, KE Daou, M Diarra, I Kone, A Thera, MA Heppner, G Leach, A Doumbo, OK Plowe, CV Sztein, MB AF Lyke, Kirsten E. Daou, Modibo Diarra, Issa Kone, Abdoulaye Thera, Mohamadou A. Heppner, Gray Leach, Amanda Doumbo, Ogobara K. Plowe, Christopher V. Sztein, Marcelo B. TI Cell mediated immunity elicited in semi-immune adults in Bandiagara, Mali after a randomized controlled phase I trial of Walter Reed Army Institute of Research's AMA1 antigen adjuvanted in GlaxoSmithKline Biologicals' AS02A SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Univ Maryland, Baltimore, MD 21201 USA. Univ Bamako, Bamako, Mali. Walter Reed Army Inst Res, Silver Spring, MD USA. GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 892 BP 257 EP 257 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901327 ER PT J AU Waitayakul, A Somsri, S Sattabongkot, J Looareesuwan, S Cui, LW Udomsangpetch, R AF Waitayakul, Amornrat Somsri, Sangdoa Sattabongkot, Jetsumon Looareesuwan, Sornchai Cui, Liwang Udomsangpetch, Rachanee TI Natural human humoral response to salivary gland proteins of anopheles mosquitoes in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Mahidol Univ, Fac Med Technol, Dept Parasitol, Bangkok 10700, Thailand. Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10700, Thailand. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10700, Thailand. Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 904 BP 261 EP 261 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901339 ER PT J AU Whitehouse, CA Hottel, H Vatansever, Z Deniz, A Ergonul, O Paragas, J Garrison, A Kondig, JP Wasieloski, LP AF Whitehouse, Chris A. Hottel, Hannah Vatansever, Zati Deniz, Ahmet Ergonul, Onder Paragas, Jason Garrison, Aura Kondig, John P. Wasieloski, Leonard P. TI First molecular detection of crimean-congo hemorrhagic fever virus in ticks from Turkey SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USA, Med Res Inst Infect Dis, Fort Detrick, MD USA. Ankara Univ, Fac Med Vet, TR-06100 Ankara, Turkey. Cent Vet Res Inst, Ankara, Turkey. Marmara Univ, Istanbul, Turkey. RI vatansever, zati/A-2344-2016 OI vatansever, zati/0000-0003-3460-3849 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 957 BP 274 EP 275 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901392 ER PT J AU Kadyrov, A Shermukhamedova, D Komilov, N Khodjaev, S Bryanseva, E Umurzakov, S Paragas, J Mores, C AF Kadyrov, Akbar Shermukhamedova, Dilbar Komilov, Nemat Khodjaev, Shabot Bryanseva, Eylena Umurzakov, Shavkat Paragas, Jason Mores, Christopher TI Reappearance of CCHF and other tick-borne arboviruses in the Syrdarya region of the Republic of Uzbekistan SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Inst Virol, Tashkent, Uzbekistan. USA, Med Res Inst Infect Dis, Frederick, MD USA. Univ Florida, Vero Beach, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 961 BP 275 EP 276 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901396 ER PT J AU Bryanseva, E Komilov, N Shermukhamedova, D Khyuziahmetova, I Umurzakov, S Kalugina, L Kadyrov, A Alakbarova, S Paragas, J Mores, C AF Bryanseva, Eylena Komilov, Nemat Shermukhamedova, Dilbar Khyuziahmetova, Ilseyar Umurzakov, Shavkat Kalugina, Lyudmila Kadyrov, Akbar Alakbarova, Saida Paragas, Jason Mores, Christopher TI Tick-borne arbovirus surveillance in Uzbekistan SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Inst Virol, Tashkent, Uzbekistan. USA, Med Res Inst Infect Dis, Frederick, MD USA. Univ Florida, Vero Beach, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 963 BP 276 EP 276 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901398 ER PT J AU Coller, BA Lieberman, M Putnak, JR Clements, D Ogata, S Thorne, M Martyak, T Chang, D Lehrer, A Wong, T Weeks-Levy, C AF Coller, Beth-Ann Lieberman, Michael Putnak, J. Robert Clements, David Ogata, Steven Thorne, Michael Martyak, Timothy Chang, David Lehrer, Axel Wong, Teri Weeks-Levy, Carolyn TI Safe, effective, recombinant subunit vaccine for protection against dengue virus induced disease SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Hawaii Biotech Inc, Aiea, HI USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 980 BP 281 EP 281 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901415 ER PT J AU Van Gessel, Y Putnak, R Gettayacamin, M Klade, C Tauber, E Lyons, A Sun, W Dewasthaly, S AF Van Gessel, Yvonne Putnak, Robert Gettayacamin, Montip Klade, Christoph Tauber, Erich Lyons, Art Sun, Wellington Dewasthaly, Shailesh TI Passive transfer of human antibodies against a new Japanese encephalitis virus vaccine protects mice against lethal dose of virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Walter Reed Army Med Ctr, Silver Spring, MD USA. Intercell AG, Vienna, Austria. RI Lyons, Arthur/B-8923-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 984 BP 282 EP 283 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901419 ER PT J AU Ohrt, C Ogutu, B Martin, K Obare, P Adiambo, C Awando, K Prudhomme, W Remich, S Chretien, JP Lucas, C Osoga, J McEvoy, P Odera, JS Lucas, M Nanakorn, A AF Ohrt, Colin Ogutu, Bernhards Martin, Kurt Obare, Peter Adiambo, Christine Awando, Ken Prudhomme, Wendy Remich, Shon Chretien, Jean Paul Lucas, Carmen Osoga, Joseph McEvoy, Peter Odera, James Sande Lucas, Martin Nanakorn, Ampon TI Malaria diagnostics centre for excellence: Microscopy objective testing results and plans for certification SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Walter Reed Army Inst Res, Germantown, MD USA. Kenya Govt Med Res Ctr, Kisumu, Kenya. USA, Med Res Unit Kenya, Kisumu, Kenya. Wellcome Trust Res Labs, Kilifi, Kenya. NIH, Fogarty Unit, Bethesda, MD 20892 USA. USA, Med Res Unit, Nairobi, Kenya. Walter Reed Army Inst Res, Silver Spring, MD USA. Naval Med Res Ctr Detachment, Lima, Peru. Armed Forces Inst Pathol, Washington, DC 20306 USA. Ctr Dis Control & Prevent, Kisumu, Kenya. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 998 BP 287 EP 287 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901433 ER PT J AU Gibbons, RV Ajariyakhajorn, C Nisalak, A Jarman, RG Green, S Mammen, MP Perng, GC AF Gibbons, Robert V. Ajariyakhajorn, Chuanpis Nisalak, Ananda Jarman, Richard G. Green, Sharone Mammen, Mammen P. Perng, Guey Chuen TI AB blood group appears to be a risk factor for severe dengue disease in secondary dengue infection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Armed Forces Res Inst Med Sci, USA, Bangkok 10400, Thailand. Univ Massachusetts, Sch Med, Ctr Infect Dis Vaccine Res, Worcester, MA 01605 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 1010 BP 291 EP 291 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901445 ER PT J AU Aguiar, JC Iriko, H Huang, FY Sacci, JB Juompan, L Jin, L Han, ET Takeo, S Krzych, U Endo, Y Richie, T Tsuboi, T AF Aguiar, Joao Carlos Iriko, Hideyuki Huang, Fengying Sacci, John B. Juompan, Laure Jin, Ling Han, Eun-Taek Takeo, Satoru Krzych, Urszula Endo, Yaeta Richie, Thomas Tsuboi, Takafumi TI Discovering novel malaria pre-erythrocytic antigens SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 Naval Med Res Ctr, Silver Spring, MD USA. Ehime Univ, Venture Business Lab, Matsuyama, Ehime, Japan. Univ Maryland, Sch Med, Dept Microbiol, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. Ehime Univ, Cell Free Sci & Tech Res Ctr, Matsuyama, Ehime 790, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 SU S MA 1048 BP 303 EP 303 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 109XW UT WOS:000242343901483 ER PT J AU Li, QG Xie, LH Haeberle, A Zhang, J Weina, P AF Li, Qigui Xie, Lisa H. Haeberle, Adam Zhang, Jing Weina, Peter TI The evaluation of radiolabeled artesunate on tissue distribution in rats and protein binding in humans SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FALCIPARUM-MALARIA; ORAL ARTESUNATE; ARTELINIC ACID; IN-VITRO; PLASMODIUM-FALCIPARUM; ARTEETHER; PHARMACOKINETICS; ARTEMISININ; NEUROTOXICITY; ARTEMETHER AB The present study reports the tissue distribution, pharmacokinetics, mass balance, and elimination of [C-14] artesunate (AS) following single intravenous administration in rats. Protein binding was performed with rat and human plasma. Radioactivity and drug levels in blood, plasma, tissues, urine, and feces up to 192 hours were collected and measured. The mean terminal half-life of plasma (76 h) and blood (105 h) radioactivity was prolonged compared with that of unchanged AS (0.43 h) and dihydroartemisinin (0.75 h), an active metabolite of AS. Drug was widely distributed after 1 hour in select tissues. After 24 hours, the radioactivity rapidly declined in all tissues except spleen until 96 hours. Only 1% of total radioactivity was detected in brain tissue. AS revealed a higher binding capacity with human and rat plasma proteins (73-81%). The radioactivity in whole blood was higher (two to fourfold) than that in plasma throughout the period of the treatment, suggesting that AS binding to RBCs may relate to its powerful antimalarial activity. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20307 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20307 USA. EM qigui.li@na.amedd.army.mil RI Weina, Peter/A-2120-2011 NR 31 TC 21 Z9 22 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 BP 817 EP 826 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 107RQ UT WOS:000242189100009 PM 17123971 ER PT J AU Bruckova, M Bautista, CT Graham, RR Maly, M Vandasova, J Presl, J Sumegh, L Chapman, GD Carr, JK Sanchez, JL Earhart, KC AF Bruckova, Marie Bautista, Christian T. Graham, Ross R. Maly, Marek Vandasova, Jana Presl, Jiri Sumegh, Laszlo Chapman, Gail D. Carr, Jean K. Sanchez, Jose L. Earhart, Kenneth C. TI Short report: HIV infection among commercial sex workers and injecting drug users in the Czech Republic SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Since the first HIV case was diagnosed in the Czech Republic in 1985, there is a lack of information regarding the epidemiology of HIV infection in most high-risk groups. To determine the prevalence of, and risk factors for, HIV among female and male commercial sex workers (FCSW and MCSW, respectively) and injecting drug users (IDUs), cross-sectional studies were conducted in the cities of Cheb, Usti nad Labem, Ostrava, and Prague of the Czech Republic. A total of 1,277 subjects were enrolled, which included 585 FCSWs, 230 MCSWs, and 462 IDUs. The HIV prevalences were 0.7% (95% CI: 0.2-1.7%),0.9% (95% CI: 0.1-3.1%), and 0.2% (95% Cl: 0.005-1.2%) among FCSWs, MCSWs, and IDUs, respectively. Although low HIV prevalences were found, ongoing sentinel surveillance studies, which address modifiable behavioral and biologic risk factors among high-risk groups, are necessary to guide strategies to stem the tide of the epidemic in this country. C1 USN, Med Res Unit 3, Virol Res Program, Cairo, Egypt. Natl Reference Lab AIDS, Prague, Czech Republic. Walter Reed Army Inst Res, US Military, HIV Res Program, Rockville, MD USA. Henry M Jackson Fdn Advancement Mil Med Inc, Rockville, MD USA. Drop IVDU Ctr, Prague, Czech Republic. Project Sance, Prague, Czech Republic. Walter Reed Army Inst Res, Dept Def Global Emerging Infect, Surveillance & Response Syst, DoD,GEIS, Silver Spring, MD USA. RP Earhart, KC (reprint author), USN, Med Res Unit 3, Virol Res Program, Cairo, Egypt. EM bruckova@szu.cz; cbautista@hivresearch.org; carhartK@namru3.med.navy.mil RI Bautista, Christian/B-2812-2011; Maly, Marek/G-8964-2014 NR 14 TC 11 Z9 12 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2006 VL 75 IS 5 BP 1017 EP 1020 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 107RQ UT WOS:000242189100043 PM 17124005 ER PT J AU LeBreton, M Prosser, AT Tamoufe, U Sateren, W Mpoudi-Ngole, E Diffo, JLD Burke, DS Wolfe, ND AF LeBreton, M. Prosser, A. T. Tamoufe, U. Sateren, W. Mpoudi-Ngole, E. Diffo, J. L. D. Burke, D. S. Wolfe, N. D. TI Patterns of bushmeat hunting and perceptions of disease risk among central African communities SO ANIMAL CONSERVATION LA English DT Article DE hunting; bushmeat; endangered species; conservation; zoonosis; cross-species transmission; education; public health ID CONGO BASIN; TRANSMISSION; WILDLIFE; CONSERVATION; HUNTERS; VIRUSES; HEALTH AB There is a great need to determine the factors that influence the hunting, butchering and eating of bushmeat to better manage the important social, public health and conservation consequences of these activities. In particular, the hunting and butchering of wild animals can lead to the transmission of diseases that have potentially serious consequences for exposed people and their communities. Comprehension of these risks may lead to decreased levels of these activities. To investigate these issues, 3971 questionnaires were completed to examine the determinants of the hunting, butchering and eating of wild animals and perceptions of disease risk in 17 rural central African villages. A high proportion of individuals reported perceiving a risk of disease infection with bushmeat contact. Individuals who perceived risk were significantly less likely to butcher wild animals than those who perceived no risk. However, perception of risk was not associated with hunting and eating bushmeat (activities that, compared with butchering, involve less contact with raw blood and body fluids). This suggests that some individuals may act on perceived risk to avoid higher risk activity. These findings reinforce the notion that conservation programs in rural villages in central Africa should include health-risk education. This has the potential to reduce the levels of use of wild animals, particularly of certain endangered species (e.g. many non-human primates) that pose a particular risk to human health. However, as the use of wild game is likely to continue, people should be encouraged to undertake hunting and butchering more safely for their own and their community's health. C1 Walter Reed Johns Hopkins Cameroon Program, CRESAR, Yaounde, Cameroon. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. Walter Reed Army Inst Res, Rockville, MD USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. RP LeBreton, M (reprint author), Walter Reed Johns Hopkins Cameroon Program, CRESAR, Yaounde, Cameroon. EM mlebreton@hopkinscameroon.org OI /0000-0002-5704-8094 NR 26 TC 23 Z9 23 U1 3 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1367-9430 EI 1469-1795 J9 ANIM CONSERV JI Anim. Conserv. PD NOV PY 2006 VL 9 IS 4 BP 357 EP 363 DI 10.1111/j.1469-1795.2006.00030.x PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 096OM UT WOS:000241386700001 ER PT J AU Adams, BD AF Adams, Bruce D. TI Chest radiography: The trauma team point of view SO ANNALS OF EMERGENCY MEDICINE LA English DT Letter C1 USA, Med Corps, Dept Emergency Med, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Adams, BD (reprint author), USA, Med Corps, Dept Emergency Med, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD NOV PY 2006 VL 48 IS 5 BP 637 EP 638 DI 10.1016/j.annemergmed.2006.05.035 PG 2 WC Emergency Medicine SC Emergency Medicine GA 101OF UT WOS:000241749400032 PM 17052574 ER PT J AU Malik, G Gorbounov, N Das, S Gurusamy, N Otani, H Maulik, N Goswami, S Das, DK AF Malik, Gautam Gorbounov, Nikolai Das, Samarjit Gurusamy, Narasimman Otani, Hajime Maulik, Nilanjana Goswami, Shyamal Das, Dipak K. TI Ischemic preconditioning triggers nuclear translocation of thioredoxin and its interaction with Ref-1 potentiating a survival signal through the PI-3-kinase-Akt pathway (Retracted article. See vol. 16, pg. 746, 2012) SO ANTIOXIDANTS & REDOX SIGNALING LA English DT Article; Retracted Publication ID NF-KAPPA-B; CARDIOMYOCYTE APOPTOSIS; REPERFUSION INJURY; DIRECT ASSOCIATION; HEART; PROTEIN; STRESS; CELLS; AP-1; TRANSACTIVATION AB Thioredoxin (Trx-1), a key mediator of cellular redox homeostasis and cell survival, is implicated in redox signaling in the ischemic myocardium. To investigate further its mechanism of action, Trx expression in rat heart was suppressed by direct injection of small hairpin RNA against Trx-1 (shRNA-Trx-1). Forty-eight hours after treatment, hearts were excised for isolated working-heart preparation. A group of hearts was preconditioned (PC) by subjecting them to four cyclic episodes of 5-min ischemia, each followed by 10 min of reperfusion. All the hearts, PC or non-PC, were subjected to 30-min ischemia followed by 2 h of reperfusion. As expected, the PC hearts exhibited improved ventricular function, reduced infarct size, and cardiomyocyte apoptosis. Also in PC hearts, an increase was noted in Trx-1 and other cardioprotective and redox-regulated proteins like Ref-1, phospho-Akt, and NF-kappa B DNA-binding activity. PC also caused nuclear translocation of Trx-1 and Ref-1 followed by their association. However, in hearts treated with shRNA-Trx1, the cardioprotective effects of PC were abolished along with a concomitant decrease in nuclear localized Trx-1 and Ref-1, along with a decrease in phospho-Akt and NF-kappa B. These results demonstrate that PC triggers translocation of Trx-1 into the nucleus, where it becomes associated with Ref-1 and performs redox signaling through the activation of NF-kappa B and an increase in prosurvival signal inducer phospho-Akt. C1 Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Das, DK (reprint author), Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. EM ddas@neuron.uchc.edu FU NHLBI NIH HHS [HL 34360, HL56803, HL33889, HL69910, HL22559] NR 31 TC 32 Z9 35 U1 5 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1523-0864 EI 1557-7716 J9 ANTIOXID REDOX SIGN JI Antioxid. Redox Signal. PD NOV-DEC PY 2006 VL 8 IS 11-12 BP 2101 EP 2109 DI 10.1089/ars.2006.8.2101 PG 9 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 100BD UT WOS:000241641200014 PM 17034353 ER PT J AU Inglis, TJJ Sagripanti, JL AF Inglis, Timothy J. J. Sagripanti, Jose-Luis TI Environmental factors that affect the survival and persistence of Burkholderia pseudomallei SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Review ID PSEUDOMONAS-PSEUDOMALLEI; LEGIONELLA-PNEUMOPHILA; HARTMANNELLA-VERMIFORMIS; BACTEREMIC MELIOIDOSIS; POTABLE WATER; MURINE MODEL; IDENTIFICATION; SOIL; EPIDEMIOLOGY; THAILAND C1 USA, RDECOM, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. QEII Med Ctr, PathWest Lab Med, Div Microbiol & Infect Dis, Nedlands, WA 6909, Australia. RP Sagripanti, JL (reprint author), AMSRD, ECB RT, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 91 TC 71 Z9 74 U1 2 U2 18 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD NOV PY 2006 VL 72 IS 11 BP 6865 EP 6875 DI 10.1128/AEM.01036-06 PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 105BH UT WOS:000242003800001 PM 16980433 ER PT J AU Crocker, FH Indest, KJ Fredrickson, HL AF Crocker, Fiona H. Indest, Karl J. Fredrickson, Herbert L. TI Biodegradation of the cyclic nitramine explosives RDX, HMX, and CL-20 SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Review ID DEGRADATION REACTION-MECHANISMS; MUNICIPAL ANAEROBIC SLUDGE; CLOSTRIDIUM SP EDB2; WHITE-ROT FUNGUS; SP STRAIN DN22; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; CATALYZED BIOTRANSFORMATION; DIFFERENTIAL DISPLAY; MESSENGER-RNA; 2,4,6,8,10,12-HEXANITRO-2,4,6,8,10,12-HEXAAZAISOWURTZITANE CL-20 AB Cyclic nitramine explosives are synthesized globally mainly as military munitions, and their use has resulted in environmental contamination. Several biodegradation pathways have been proposed, and these are based mainly on end-product characterization because many of the metabolic intermediates are hypothetical and unstable in water. Biodegradation mechanisms for cyclic nitramines include (a) formation of a nitramine free radical and loss of nitro functional groups, (b) reduction of nitro functional groups, (c) direct enzymatic cleavage, (d) alpha-hydroxylation, or (e) hydride ion transfer. Pathway intermediates spontaneously decompose in water producing nitrite, nitrous oxide, formaldehyde, or formic acid as common end-products. In vitro enzyme and functional gene expression studies have implicated a limited number of enzymes/genes involved in cyclic nitramine catabolism. Advances in molecular biology methods such as high-throughput DNA sequencing, microarray analysis, and nucleic acid sample preparation are providing access to biochemical and genetic information on cultivable and uncultivable microorganisms. This information can provide the knowledge base for rational engineering of bioremediation strategies, biosensor development, environmental monitoring, and green biosynthesis of explosives. This paper reviews recent developments on the biodegradation of cyclic nitramines and the potential of genomics to identify novel functional genes of explosive metabolism. C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Crocker, FH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Fiona.H.Crocker@erdc.usace.army.mil NR 114 TC 69 Z9 70 U1 5 U2 45 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD NOV PY 2006 VL 73 IS 2 BP 274 EP 290 DI 10.1007/s00253-006-0588-y PG 17 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 107BA UT WOS:000242144500003 PM 17058075 ER PT J AU Govindaraju, N Aleksov, A Li, X Okuzumi, F Wolter, SD Collazo, R Prater, JT Sitar, Z AF Govindaraju, N. Aleksov, A. Li, X. Okuzumi, F. Wolter, S. D. Collazo, R. Prater, J. T. Sitar, Z. TI Comparative study of textured diamond films by thermal conductivity measurements SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article ID BIAS-ENHANCED NUCLEATION; HIGHLY ORIENTED DIAMOND; CVD DIAMOND; FREQUENCY; SILICON; GROWTH AB Superior thermal conductivity, high resistance, high breakdown voltage and wide band gap make diamond an attractive material for a variety of applications in electronics. One of its most appealing applications is as a buried dielectric in silicon-on-diamond (SOD) technology. This paper presents thermal conductivity measurements conducted on a series of diamond films (grown by the microwave plasma chemical vapor deposition technique) as a function of the sample morphology and thickness, for eventual incorporation in the SOD structures. Results show that there is a significant difference in the measured thermal conductivity between samples with fiber texture and samples with sheet texture. Also, measurements performed on a 160-mu m-thick diamond sample before and after reactive ion etching of approximately 10 mu m of the nucleation layer show no significant change in the measured value of the thermal conductivity. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Govindaraju, N (reprint author), Univ Cincinnati, 400 Rhodes Hall, Cincinnati, OH 45221 USA. EM govindnl@email.uc.edu NR 15 TC 5 Z9 6 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0947-8396 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD NOV PY 2006 VL 85 IS 3 BP 331 EP 335 DI 10.1007/s00339-006-3697-7 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 096CP UT WOS:000241354900017 ER PT J AU McCleskey, PE Winter, KJ DeVillez, RL AF McCleskey, Patrick E. Winter, Kelly J. DeVillez, Richard L. TI Tender papules on the hands - Idiopathic chilblains (perniosis) SO ARCHIVES OF DERMATOLOGY LA English DT Article C1 USAF, Washington, DC 20330 USA. Brooke Army Med Ctr, San Antonio, TX USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP McCleskey, PE (reprint author), USAF, Washington, DC 20330 USA. NR 5 TC 5 Z9 5 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD NOV PY 2006 VL 142 IS 11 BP 1501 EP 1502 DI 10.1001/archderm.142.11.1501-a PG 2 WC Dermatology SC Dermatology GA 107GB UT WOS:000242157600017 PM 17116847 ER PT J AU Sweeney, RE Langenberg, JP Maxwell, DM AF Sweeney, Richard E. Langenberg, Jan P. Maxwell, Donald M. TI A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes of soman in multiple species SO ARCHIVES OF TOXICOLOGY LA English DT Article ID GUINEA-PIG; TOXICOKINETICS; RAT AB A physiologically based pharmacokinetic (PB/PK) model has been developed in advanced computer simulation language (ACSL) to describe blood and tissue concentration-time profiles of the C(+/-)P(-) stereoisomers of soman after inhalation, subcutaneous and intravenous exposures at low (0.8-1.0 x LD50), medium (2-3 x LD50) and high (6 x LD50) levels of soman challenge in three species (rat, guinea pig, marmoset). Allometric formulae were used to compute the compartment volumes, blood flow rates, tidal volume and respiratory rate based upon total animal weight. Blood/tissue partition coefficients for soman, initial carboxylesterase and acetylcholinesterase levels and the rate constants for interactions between soman and these enzymes were species-dependent and were obtained from in vitro measurements reported in the literature. The model incorporated arterial and venous blood, lung, kidney, liver, richly perfused, poorly perfused and fat tissue compartments as well as subcutaneous and nasal exposure site compartments. First-order absorption from linearly filled soman deposits into metabolizing exposure site compartments was employed to model subcutaneous and inhalation exposures. The model was validated by comparing the predicted and observed values for C(+/-)P(-)-soman in arterial blood at various times following exposure and by regression analysis. Sensitivity analysis was used to determine the effects of perturbations in the model parameters on the time-course of arterial C(-)P(-)-soman concentrations for different exposure routes. In our evaluation of 28 datasets, predicted values were generally within 95% confidence limits of the observed values, and regression coefficients comparing predicted and observed data were greater than 0.85 for 95% of the intravenous and subcutaneous datasets and 25% of the inhalation datasets. We conclude that the model predicts the soman toxicokinetics for doses >= 1 x LD50 for intravenous and subcutaneous exposures and inhalation exposures of 8 min or less sufficiently well to allow its use in the modeling of bioscavenger protection. C1 RESECO Res Engn Consultants, Nottingham, PA 19362 USA. TNO, Def Secur & Safety, NL-2280 AA Rijswijk, Netherlands. USA, Inst Med Res, Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Sweeney, RE (reprint author), RESECO Res Engn Consultants, POB 554, Nottingham, PA 19362 USA. EM Richard.Sweeney@us.army.mil NR 15 TC 11 Z9 12 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 2006 VL 80 IS 11 BP 719 EP 731 DI 10.1007/s00204-006-0114-0 PG 13 WC Toxicology SC Toxicology GA 109GB UT WOS:000242294800001 PM 16718492 ER PT J AU Maxwell, DM Brecht, KM Koplovitz, I Sweeney, RE AF Maxwell, Donald M. Brecht, Karen M. Koplovitz, Irwin Sweeney, Richard E. TI Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds? SO ARCHIVES OF TOXICOLOGY LA English DT Article DE organophosphorus; acetylcholinesterase inhibition; oxime reactivation; dose-response; toxic mechanism ID PESTICIDES; PROTECTION; OXIMES; SOMAN AB The hypothesis that acetylcholinesterase (AChE) inhibition is the mechanism of toxicity of organophosphorus (OP) compounds was examined by mathematically modeling the in vivo lethal effects of OP compounds and determining the amount of variation in OP toxicity that is explained by AChE inhibition. Mortality dose-response curves for several OP compounds (i.e., VX, soman, cyclosarin, sarin, tabun, diisopropylfluorophosphate and paraoxon) exhibited steep probit slopes (> 9.6) in guinea pigs. Steep probit slopes were also observed when the mortality dose-response curves for soman were examined in mice, rats, rabbits and non-human primates. The consistently steep probit slopes of the dose-response curves for highly toxic OP compounds suggested that these compounds have a single specific mechanism of toxicity regardless of the OP compound or the species in which it was tested. Regression analysis indicated that 93% of the 3,280-fold variation in the median lethal doses (i.e., LD50) of OP compounds in rats was explained by the variation in their in vitro rate constants for inhibition of AChE. Conversely, 91% of the 23-fold variation in the ability of the oximes pralidoxime and obidoxime to protect against the toxicity of OP compounds in guinea pigs was explained by the variation in the in vitro ability of oximes to reactivate OP-inhibited AChE. The best explanation for this variety of observations was that the primary mechanism of in vivo toxicity for highly toxic OP compounds is the inhibition of AChE, and the residual unexplained variation in OP toxicity that might be explained by other mechanisms represents < 10% of the total variation in OP toxicity. C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Maxwell, DM (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM donald.maxwell@amedd.army.mil NR 21 TC 51 Z9 52 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 2006 VL 80 IS 11 BP 756 EP 760 DI 10.1007/s00204-006-0120-2 PG 5 WC Toxicology SC Toxicology GA 109GB UT WOS:000242294800005 PM 16770629 ER PT J AU Shih, TM Scremin, OU Roch, M Huynh, L Sun, W Jenden, DJ AF Shih, Tsung-Ming Scremin, Oscar U. Roch, Margareth Huynh, Ly Sun, Wei Jenden, Donald J. TI Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats SO ARCHIVES OF TOXICOLOGY LA English DT Article DE nerve agent; sarin; pyridostigmine; acetylcholine metabolism ID GULF-WAR-SYNDROME; GAS-CHROMATOGRAPHY; MASS-SPECTROMETRY; BLOOD-FLOW; BRAIN; SOMAN; TOXICITY; METABOLISM; MECHANISMS; PYRIDOSTIGMINE AB Male Sprague-Dawley rats were treated for 3 weeks with (1) regular tap drinking water plus subcutaneous (s.c.) saline (0.5 ml/kg) injections three times/week, (2) pyridostigmine bromide (PB) in drinking water (80 mg/L) plus s.c. saline injections three times/week, (3) regular tap drinking water plus s.c. sarin (0.5 x LD50) injections three times/week, or (4) PB in drinking water plus s.c. sarin injections three times/week. Repeated doses of sarin, in the presence or absence of PB, were devoid of acute toxicity during the three-week treatment period. Two, 4, and 16 weeks post-treatment, animals were given an intravenous pulse injection of choline labeled with 4 deuterium atoms (D4Ch) followed, after 1 min, by microwave fixation of the brain in vivo. Tissue levels of endogenous acetylcholine (D0ACh), endogenous choline (D0Ch), D4Ch, and ACh synthesized from D4Ch (D4ACh) were measured by gas-chromatography mass-spectrometry in hippocampus, infundibulum, mesencephalon, neocortex, piriform cortex, and striatum. Ch uptake from blood and ACh turnover were estimated from D4Ch and D4ACh concentrations in brain tissue, respectively. Statistically significant differences among brain regions were found for D0Ch, D4Ch, D0ACh and D4ACh at 2, 4 and 16 weeks post-treatment. However, differences in the values of these parameters between control and drug treatments were found only for D0ACh and D0Ch at 2 and 4 weeks, but not at 16 weeks post-treatment. In conclusion, the results from these experiments do not support a delayed or persistent alteration in cholinergic function after exposure to low doses of PB and/or sarin. C1 USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. VA GLA Healthcare Syst, Res Dept, Los Angeles, CA USA. Univ Calif Los Angeles, Dept Physiol, David Geffen Sch Med, Los Angeles, CA 90024 USA. Univ Calif Los Angeles, Med & Mol Pharmacol Dept, David Geffen Sch Med, Los Angeles, CA 90024 USA. RP Shih, TM (reprint author), USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil NR 38 TC 5 Z9 6 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 2006 VL 80 IS 11 BP 761 EP 767 DI 10.1007/s00204-006-0101-5 PG 7 WC Toxicology SC Toxicology GA 109GB UT WOS:000242294800006 PM 16628397 ER PT J AU Cooke, WH Salinas, J McManus, JG Ryan, KL Rickards, CA Holcomb, JB Convertino, VA AF Cooke, William H. Salinas, Jose McManus, John G. Ryan, Kathy L. Rickards, Caroline A. Holcomb, John B. Convertino, Victor A. TI Heart period variability in trauma patients may predict mortality and allow remote triage SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE injury severity; triage; Fourier analysis; autonomic balance ID SYMPATHOVAGAL BALANCE; SPECTRAL-ANALYSIS; SEPSIS; DOMAIN; BEAT AB Introduction: The high frequency to low frequency ratio (HF/LF) derived from analysis of heart period variability is elevated and associated with mortality in severely injured patients monitored in a hospital. The purpose of this study was to test the utility of heart period variability measurements as indicators of injury severity in patients prior to definitive medical intervention. We tested the hypothesis that survival is associated with low relative HF/LF, and death is associated with high relative HF/LF. Methods: We performed retrospective analyses of 84 pre-hospital trauma patient records (n = 42 non-survivors; n = 42 survivors) collected during helicopter transport to a Level 1 urban trauma center. R-waves from 2-min segments of ECG waveforms were converted to the frequency domain with a Fourier transform. Spectral power was separated into low (LF; 0.04-0.15 Hz) and high (HF; 0.15-0.4 Hz) frequency bands for analysis and derivation of frequency ratios. Results: Absolute HF, LF, and HF/LF were not distinguishable statistically between groups (p >= 0.26), but HF/LF was higher (p = 0.04) for non-survivors (140 +/- 26) than survivors (74 +/- 19). After normalization to account for large intersubject variability, HFnu (43 +/- 3 vs. 28 +/- 2) and HF/LFnu (248 +/- 50 vs. 73 +/- 19) were higher (both p < 0.001), and LFnu (42 +/- 4 vs. 64 +/- 3) was lower (p = 0.0001) for non-survivors [19 h (median) before death] compared with survivors. Conclusions: Our results show that heart period variability analyses separate patients who die from patients who survive traumatic injury. We propose that such analyses could be employed for remote triage of injured patients in austere environments. C1 Univ Texas, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cooke, WH (reprint author), Univ Texas, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. EM william.cooke@utsa.edu NR 25 TC 29 Z9 29 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2006 VL 77 IS 11 BP 1107 EP 1112 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 101VH UT WOS:000241768500001 PM 17086761 ER PT J AU Journeay, WS Carter, R Kenny, GP AF Journeay, W. Shane Carter, Robert, III Kenny, Glen P. TI Thermoregulatory control following dynamic exercise SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE post-exercise hypotension; heat stress; hypohydration; exercise recovery; non-thermal reflexes ID CUTANEOUS VASCULAR CONDUCTANCE; ACTIVE VASODILATOR SYSTEM; BODY NEGATIVE-PRESSURE; SKIN BLOOD-FLOW; POSTEXERCISE HYPOTENSION; HEAT-STRESS; MODERATE EXERCISE; SWEAT RATE; CARDIOVASCULAR-RESPONSES; NONTHERMOREGULATORY CONTROL AB Post-exercise thermoregulatory control in humans has received limited attention. In the post-exercise period skin blood flow and sweating return to pre-exercise levels despite a persistent elevation in esophageal temperature, suggesting an alteration in thermoregulatory control. The esophageal temperature response post-exercise appears to be correlated to the marked cardiovascular changes that occur after dynamic exercise. Recent work has shown that non-thermoregulatory factors associated with hemodynamic changes and hydration status post-exercise may influence the regulation of core temperature during exercise recovery. This review will characterize the thermal response and describe our current understanding of the physiological influences on thermoregulatory control during recovery from dynamic exercise. C1 Univ Ottawa, Sch Human Kinet, Fac Hlth Sci, Lab Human Bioenerget & Environm Physiol, Ottawa, ON K1N 6N5, Canada. Univ Saskatchewan, Toxicol Grad Program, Saskatoon, SK S7N 0W0, Canada. Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 0W0, Canada. USA, Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. Serv Sante Armees, Ctr Rech, Dept Human Factors, La Tronche, France. RP Kenny, GP (reprint author), Univ Ottawa, Sch Human Kinet, Fac Hlth Sci, Lab Human Bioenerget & Environm Physiol, 125 Univ,Montpetit Hall,Room 372, Ottawa, ON K1N 6N5, Canada. EM gkenny@uottawa.ca NR 74 TC 17 Z9 17 U1 1 U2 8 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2006 VL 77 IS 11 BP 1174 EP 1182 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 101VH UT WOS:000241768500014 PM 17086774 ER PT J AU McClellan, SF Bernstein, S AF McClellan, Scott F. Bernstein, Stephen TI The role of aeronautical adaptability in the disqualification of a military flyer SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE aeronautical adaptability; crew coordination; personality disorder; safety of flight ID RIGHT STUFF; PERSONALITY AB Introduction: Possessing a stable personality plays a critical role in crew coordination, mission completion, and safety of flight in aviation. Presented is a naval flight officer whose personality traits were a threat to these key tenets and ultimately warranted removal from flight status. Case Report. A naval flight officer was twice referred to Human Factors Boards (HFBs) after concerns were raised about her emotional stability in and out of the cockpit. Her history revealed multiple clinical presentations revealing personality characteristics that should have raised immediate concern about her aeronautical adaptability. Formal psychiatric evaluation after her second HFB confirmed the presence of personality traits incompatible with aviation duty, but not until she had served nearly 4 yr as an aviation officer. Discussion: Aeronautical adaptability is a U.S. Naval term used to describe an individual's ability to work successfully in the aviation environment. Naval aviation personnel are considered not aeronautically adaptable/adapted if diagnosed with a "personality disorder or prominent personality traits that adversely affect flight safety, mission completion, or crew coordination." The Federal Aviation Administration, the U.S. Air Force, and the U.S. Army endorse similar concepts. Except for the U.S. Navy definition, aeronautical adaptability does not include formal DSM-IV-TR diagnoses, and, thus, flight surgeons and aviation medical examiners often make difficult aeromedical dispositions based on vague and subjective criteria. Conclusions: Determining aeronautical adaptability is not a simple, solitary process. It requires heightened suspicion, continual surveillance of suspect aviators, and collaboration from aviation medical professionals to ensure aviation safety. C1 USA, Aeromed Act, Aeromed Ctr, Ft Rucker, AL 36362 USA. RP Bernstein, S (reprint author), USA, Aeromed Act, Aeromed Ctr, Bldg 301,Andrews Ave, Ft Rucker, AL 36362 USA. EM audiemomac@mac.com NR 10 TC 1 Z9 3 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2006 VL 77 IS 11 BP 1188 EP 1192 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 101VH UT WOS:000241768500016 PM 17086776 ER PT J AU Thorne, DR AF Thorne, David R. TI Throughput: A simple performance index with desirable characteristics SO BEHAVIOR RESEARCH METHODS LA English DT Article ID SPEED-ACCURACY TRADEOFF AB Throughput is a corrected response rate measure giving the number of successes per unit of discretionary time. It is a simple but general index applicable to psychomotor, behavioral, and cognitive tasks in which response times are measured. This measure has several attractive features: (1) It allows comparisons to be made across various tasks in which speed and accuracy are meaningful and measurable, independently of temporal differences in hardware, software, and procedures; (2) under conditions in which both speed and accuracy decline (or improve), throughput will be a more sensitive index of performance than either alone will be; and (3) in those tasks in which the speed-accuracy trade-off phenomenon operates, throughput will tend to be relatively less variable than either component alone will be. The measure allows both behavioral and information-processing interpretations of data and may be useful as a simple composite index, a measure of effectiveness or of cognitive consistency in studies investigating performance degradation or enhancement. C1 Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci, Silver Spring, MD 20910 USA. RP Thorne, DR (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.thorne@us.army.mil NR 15 TC 36 Z9 36 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 USA SN 1554-351X J9 BEHAV RES METHODS JI Behav. Res. Methods PD NOV PY 2006 VL 38 IS 4 BP 569 EP 573 PG 5 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA 141LI UT WOS:000244579600003 PM 17393825 ER PT J AU Gutteridge, CE Nichols, DA Curtis, SM Thota, DS Vo, JV Gerena, L Montip, G Asher, CO Diaz, DS DiTusa, CA Smith, KS Bhattacharjee, AK AF Gutteridge, Clare E. Nichols, Daniel A. Curtis, Sean M. Thota, Darshan S. Vo, Joseph V. Gerena, Lucia Montip, Gettayacamin Asher, Constance O. Diaz, Damaris S. DiTusa, Charles A. Smith, Kirsten S. Bhattacharjee, Apurba K. TI In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE malaria; chalcone; quinoline; metabolism ID ANTIMALARIAL ACTIVITY; LIVER-MICROSOMES; CHALCONE; MALARIA; DERIVATIVES; ANALOGS AB Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in a Plasmodium berghei infected mouse model. Significant compound degradation occurred upon their exposure to a liver microsome preparation, suggesting metabolic instability may be responsible for the lack of activity in vivo. (c) 2006 Elsevier Ltd. All rights reserved. C1 USN Acad, Dept Chem, Annapolis, MD 21402 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Gutteridge, CE (reprint author), USN Acad, Dept Chem, Annapolis, MD 21402 USA. EM gutterid@usna.edu RI DiTusa, Charles/A-9143-2011 NR 12 TC 21 Z9 22 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD NOV 1 PY 2006 VL 16 IS 21 BP 5682 EP 5686 DI 10.1016/j.bmcl.2006.08.009 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 097KV UT WOS:000241447300044 PM 16908136 ER PT J AU Plunkett, AR Brown, DS Rogers, JM Buckenmaier, CC AF Plunkett, A. R. Brown, D. S. Rogers, J. M. Buckenmaier, C. C., III TI Supraclavicular continuous peripheral nerve block in a wounded soldier: when ultrasound is the only option SO BRITISH JOURNAL OF ANAESTHESIA LA English DT Article DE continuous peripheral nerve block, ultrasound, regional anaesthesia, supraclavicular block ID BRACHIAL-PLEXUS ANESTHESIA; REGIONAL ANESTHESIA; PHANTOM AB The complex nature of combat-related injuries requires frequent operative interventions and prolonged analgesic therapy. The application of continuous peripheral nerve block (CPNB) has been an important anaesthetic tool in the management of combat soldiers wounded from the current conflicts. The severe, destructive nature of combat injuries makes placement of CPNB difficult or impossible using more common neurostimulation approaches. The use of ultrasound technology has improved our success in placing CPNB in the presence of such injuries. We report the application of ultrasound technology in placing CPNB in a combat-injured soldier, whose injuries precluded other CPNB options. C1 Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Mainagement Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. RP Plunkett, AR (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Mainagement Initiat, Anesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA. EM anthony.plunkett@na.amedd.army.mil NR 13 TC 22 Z9 25 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0007-0912 J9 BRIT J ANAESTH JI Br. J. Anaesth. PD NOV PY 2006 VL 97 IS 5 BP 715 EP 717 DI 10.1093/bja/ael218 PG 3 WC Anesthesiology SC Anesthesiology GA 094ZH UT WOS:000241277500021 PM 16914462 ER PT J AU Kauvar, DS Wolf, SE Wade, CE Cancio, LC Renz, EM Holcomb, JB AF Kauvar, David S. Wolf, Steven E. Wade, Charles E. Cancio, Leopoldo C. Renz, Evan M. Holcomb, John B. TI Burns sustained in combat explosions in Operations Iraqi and Enduring Freedom (OIF/OEF explosion burns) SO BURNS LA English DT Article DE burns; military trauma; epidemiology; prevention ID CASUALTIES; INJURIES AB Background: Burns comprise 5% of casualties evacuated from Operations Iraqi and Enduring Freedom (OIF and OEF). Many OIF/OEF burns result from the enemy's detonation of explosives. We reviewed these to evaluate mission impact and provide recommendations for improved combat burn protection. Data were compared to those from the Vietnam War. Methods: All OIF/OEF patients with significant burns are treated at the U.S. Army Institute of Surgical Research (ISR). A review from April 2003 to April 2005 was undertaken. Records were obtained and demographics, burn severity and pattern, and early outcomes recorded. Results: Two hundred and seventy-four OIF/OEF burn patients were treated, 142 (52%) sustained burns in explosions from hostile action. Age was 26 +/- 7 years (mean +/- S.D.). Mortality was 4%. The annual rate of combat explosion as a cause for burns increased from 18% to 69%, total body surface area burned increased from 15 +/- 12 to 21 +/- 23%, injury severity score rose from 8 +/- 11 to 17 +/- 18, and frequency of inhalation injury rose from 5% to 26%. Improvised explosive devices caused 55% of casualties, car bombs 16%, rocket-propelled grenades 15% and 14% other. The hands (80% of patients) and the face (77%) were the most frequently burned body areas. Burns were isolated to the hands in 6% of patients and to the face and hands in 15%. An average of 52 +/- 30% of the surface area of the hands and 45 +/- 26% of the face was burned. Mean length of stay was 24 25 days (median 14). Though 77% of patients were discharged without global disability, only 36% returned to full military duty. A similar pattern of injury and disposition was seen at the Army burn center in Vietnam (1966-1968), but mortality was higher (7.9%). Conclusion: Burns resulting from combat explosions increased in frequency, size and injury severity. Burns were concentrated on areas not protected by clothing or equipment. These injuries created long hospital stays and frequently prevented soldiers from returning to duty. While wound distribution has not changed, combat burn care has improved, and continued emphasis on military protective equipment for the hands and face is warranted. Published by Elsevier Ltd and ISBI. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kauvar, DS (reprint author), Brooke Army Med Ctr, MCHE SGD, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM david.kauvar@amedd.army.mil; steven.wolf@amedd.army.mil; charles.wade@amedd.army.mil; lee.cancio@amedd.army.mil; evan.renz@amedd.army.mil; john.holcomb@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 13 TC 61 Z9 63 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD NOV PY 2006 VL 32 IS 7 BP 853 EP 857 DI 10.1016/j.burns.2006.03.008 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 099JU UT WOS:000241590900009 PM 16899341 ER PT J AU Power, EM Trope, RL AF Power, E. Michael Trope, Roland L. TI The 2006 survey of legal developments in data management, privacy, and information security: The continuing evolution of data governance SO BUSINESS LAWYER LA English DT Article C1 Gowling Lafleur Henderson LLP, Ottawa Off, Ottawa, ON, Canada. US Mil Acad, Dept Law, New York, NY USA. RP Power, EM (reprint author), Gowling Lafleur Henderson LLP, Ottawa Off, Ottawa, ON, Canada. NR 37 TC 0 Z9 0 U1 2 U2 6 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0007-6899 J9 BUS LAWYER JI Bus. Lawyer PD NOV PY 2006 VL 62 IS 1 BP 251 EP 294 PG 44 WC Law SC Government & Law GA 138CP UT WOS:000244340900012 ER PT J AU Maxwell, GL Tian, C Risinger, J Brown, CL Rose, GS Thigpen, JT Fleming, GF Gallion, HH Brewster, WR AF Maxwell, G. Larry Tian, Chunqiao Risinger, John Brown, Carol L. Rose, G. Scott Thigpen, J. Tate Fleming, Gini F. Gallion, Holly H. Brewster, Wendy R. TI Racial disparity in survival among patients with advanced/recurrent endometrial adenocarcinoma - A Gynecologic Oncology Group study SO CANCER LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 19-23, 2005 CL Miami Beach, FL SP Soc Gynecol Oncol DE endometrial cancer; racial disparity; survival ID DOXORUBICIN PLUS CISPLATIN; PHASE-III TRIAL; CANCER STATISTICS; AFRICAN-AMERICAN; UTERINE CORPUS; WHITE WOMEN; CARCINOMA; FILGRASTIM; RACE AB BACKGROUND. Previous studies have reported shorter survival of black women compared with white women who had advanced/ recurrent endometrial cancer. It has been suggested that this may reflect racially based differences in treatment. METHODS. The authors retrospectively reviewed data from 169 black women and 982 white women with International Federation of Gynecologic Oncology (FIGO) Stage III, Stage IV, or recurrent endometrial carcinoma who were participants in 1 of 4 Gynecologic Oncology Group randomized treatment trials of doxorubicin alone or combined with paclitaxel and/or cisplatin. Demographic, histologic, treatment, and outcome data were analyzed to estimate survival, and between group comparisons were performed. RESULTS. The pooled data revealed that black women were more likely to have papillary serous histology (P < .001), Stage IV disease (P < .001), and higher tumor grade (P < .001) compared with white women, and survival was worse among black women than among white women (median survival, 10.6 months vs. 12.2 months, respectively; P < .001). A Cox proportional hazards regression analysis that was adjusted for performance status, disease stage, tumor histology, tumor grade, and treatment demonstrated worse survival for black women (hazards ratio, 1.26, 95% confidence interval, 1.06-1.51; P = .010). CONCLUSIONS. The data from a large group of women with advanced/ recurrent endometrial cancer suggested that a racial disparity in survival persists, despite the finding that black women and white women received similar treatment. Although the causes of racial disparity in endometrial cancer remain to be elucidated, socioeconomic, biologic, and cultural factors should be investigated to identify the etiologic origins of this multifactorial healthcare problem. C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. NCI, Canc Res Ctr, Bethesda, MD 20892 USA. Mem Sloan Kettering Canc Ctr, Gynecol Serv, Dept Surg, Div Gynecol Oncol,Dept Obstet & Gynecol, New York, NY 10021 USA. Univ Mississippi, Sch Med, Div Oncol, Dept Med, Jackson, MS 39216 USA. Univ Chicago, Dept Med, Chicago, IL 60637 USA. Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Magee Womens Res Inst, Pittsburgh, PA USA. Precis Therapeut Inc, Pittsburgh, PA USA. Univ Calif Irvine, Dept Obstet & Gynecol, Div Gynecol Oncol, Orange, CA 92668 USA. Univ Calif Irvine, Dept Med, Div Epidemiol, Orange, CA 92668 USA. RP Maxwell, GL (reprint author), Four Penn Ctr, Gynecol Oncol Grp, 1600 JFK Blvd,Suite 1020, Philadelphia, PA 19103 USA. EM sramsey@fhcrc.org FU NCI NIH HHS [CA 27469, CA 37517] NR 19 TC 50 Z9 50 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD NOV 1 PY 2006 VL 107 IS 9 BP 2197 EP 2205 DI 10.1002/cncr.22232 PG 9 WC Oncology SC Oncology GA 101YK UT WOS:000241777300013 PM 17001661 ER PT J AU Luo, L Ramirez, D Rood, MJ Grevillot, G Hay, KJ Thurston, DL AF Luo, Lingai Ramirez, David Rood, Mark J. Grevillot, Georges Hay, K. James Thurston, Deborah L. TI Adsorption and electrothermal desorption of organic vapors using activated carbon adsorbents with novel morphologies SO CARBON LA English DT Article DE activated carbon; carbon beads; carbon cloth; adsorption; adsorption properties ID REGENERATION; TEMPERATURE; MONOLITH; VOCS AB Novel morphologies of activated carbons such as monolith, beads and fiber cloth can effectively capture organic vapors from industrial sources. These adsorbent materials are also unique because they can undergo direct electrothermal regeneration to recover the adsorbed organic vapors for potential re-use. This investigation compares and contrasts the properties of these adsorbents when using electrothermal-swing adsorption. The adsorption systems consisted of an organic vapor generation system, an electrothermal-swing adsorption vessel, a gas detection unit, and a data acquisition and control system. The activated carbon monolith (ACM) had the lowest pressure drop, highest permeability, highest electrical resistivity and lowest cost as compared to the activated carbon beads (ACB) and the activated carbon fiber cloth (ACFC). ACB had the largest throughput ratio and lowest length of unused bed as compared to the other adsorbents. However, ACFC had the largest adsorption capacity for toluene when compared to ACM and ACB. ACFC was also faster to regenerate and had a larger concentration factor than ACM and ACB. These results describe relevant physical, electrical, adsorption and cost properties for specific morphologies of the adsorbents to more effectively capture and recover organic vapors from gas streams. (c) 2006 Elsevier Ltd. All rights reserved. C1 Univ Savoie, LOCIE, ESIGEC, Savoie Technolac, F-73376 Le Bourget Du Lac, France. Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. Ecole Natl Super Ind Chim, Inst Natl Polytech Lorraine, CNRS, Lab Sci Genie Chim, F-54001 Nancy, France. USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. Univ Illinois, Dept Gen Engn, Urbana, IL 61801 USA. RP Luo, L (reprint author), Univ Savoie, LOCIE, ESIGEC, Savoie Technolac, Campus Sci, F-73376 Le Bourget Du Lac, France. EM Lingai.LUO@univ-savoie.fr; mrood@uiuc.edu RI LUO, Lingai/H-3429-2011; OI Luo, Lingai/0000-0001-5827-5216 NR 32 TC 44 Z9 48 U1 1 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD NOV PY 2006 VL 44 IS 13 BP 2715 EP 2723 DI 10.1016/j.carbon.2006.04.007 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 092XQ UT WOS:000241131300017 ER PT J AU Taylor, S Campbell, E Perovich, L Lever, J Pennington, J AF Taylor, Susan Campbell, Eleanor Perovich, Laura Lever, James Pennington, Judith TI Characteristics of Composition B particles from blow-in-place detonations SO CHEMOSPHERE LA English DT Article DE Composition B; blow in place detonations; distribution of explosive residue ID DISSOLUTION; TNT AB We sampled residues from high-order and low-order blow-in-place detonations of mortars and projectiles filled with Composition B (Comp 13), a TNT and RDX mixture. Our goals were to (1) characterize the types of explosive particles, (2) estimate the explosive 'foot-print' for different munitions, and (3) estimate the mass of Comp B remaining after each detonation. The aerial deposition of Comp B particles helps estimate how large of an area is contaminated by a low-order detonation and how best to sample residue resulting from different rounds. We found that the high-order detonations deposited microgram to milligram quantities whereas the low-order detonations deposited gram quantities of Comp B. For the high-order detonations the concentration of Comp B in the residue decreased as a function of distance from the blast. The low-order tests scattered centimeter-sized chunks and millimeter-sized or smaller particles of Comp B. The chunks were randomly scattered whereas the number of millimeter-sized particles decreased with distance from the detonation. For both high- and low-order detonations we found that the smaller munitions deposited less Comp B than the larger munitions and deposited it closer to the detonation point. Published by Elsevier Ltd. C1 USA, Erdc, CRREL, Hanover, NH 03755 USA. USA, Erdc, Vicksburg, MS 39180 USA. RP Taylor, S (reprint author), USA, Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@erdc.usace.army.mil NR 13 TC 14 Z9 15 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2006 VL 65 IS 8 BP 1405 EP 1413 DI 10.1016/j.chemosphere.2006.03.077 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 112IK UT WOS:000242519000017 PM 16750241 ER PT J AU Bergmann-Leitner, ES Leitner, WW Tsokos, GC AF Bergmann-Leitner, Elke S. Leitner, Wolfgang W. Tsokos, George C. TI Complement 3d: From molecular adjuvant to target of immune escape mechanisms SO CLINICAL IMMUNOLOGY LA English DT Review DE adjuvant; complement; DNA vaccine; immune escape; B lymphocyte ID FOLLICULAR DENDRITIC CELLS; SIMPLEX VIRUS GLYCOPROTEIN; B-CELLS; PLASMODIUM-BERGHEI; ANTIBODY-RESPONSE; CIRCUMSPOROZOITE PROTEIN; CD19/CD21 COMPLEX; ANTIGEN RECEPTOR; NATURAL ANTIBODY; CANDIDA-ALBICANS AB CM is a fragment of the complement factor C3 and is generated in the course of complement activation. When bound to antigen in single or multiple copies, the B cell receptor and complement receptor 2 become co-crosslinked resulting in decreased or increased B cell responses depending on the valence of the antigen-C3d construct. When antigen-CM constructs are used for the purpose of generating a protective immune response (vaccines), they may either enhance the expected response or suppress it depending on the nature of the antigen. Various pathogens use C3d to evade the immune system by inhibiting complement activation, invading and homing in host cells or masking immunogenic areas of pathogen proteins. Therefore, future vaccination strategies for infectious diseases and cancer employing CM as a molecular adjuvant need to be carefully evaluated before choosing a target antigen in order to take advantage of the adjuvant effect of the complement component white avoiding potential vaccine complications associated with immune escape mechanisms. (c) 2006 Elsevier Inc. All rights reserved. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. NCI, Dermatol Branch, Clin Res Ctr, NIH, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Dept Immunol, 503 Robert Grant Ave,Room 3W76, Silver Spring, MD 20910 USA. EM elke.bergmannleitner@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922 NR 83 TC 26 Z9 28 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD NOV PY 2006 VL 121 IS 2 BP 177 EP 185 DI 10.1016/j.clim.2006.07.001 PG 9 WC Immunology SC Immunology GA 100AH UT WOS:000241638900005 PM 16914381 ER PT J AU Koff, SG Sterbis, JR Davison, JM Montilla-Soler, JL AF Koff, Stacey G. Sterbis, Joseph R. Davison, Jonathan M. Montilla-Soler, Jaime L. TI A unique presentation of appendicitis: F-18 FDG PET/CT SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE F-18; FDG; PET; appendicitis; PET/CT ID EQUIVOCAL APPENDICITIS; NUCLEAR-MEDICINE C1 Walter Reed Army Med Ctr, Dept Radiol, Nucl Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. RP Montilla-Soler, JL (reprint author), Walter Reed Army Med Ctr, Dept Radiol, Nucl Med Serv, 7A04,Bldg 2, Washington, DC 20307 USA. EM montillaj@aol.com NR 9 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 2006 VL 31 IS 11 BP 704 EP 706 DI 10.1097/01.rlu.0000242723.61455.a8 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 100EZ UT WOS:000241652100010 PM 17053390 ER PT J AU Tzeng, J Emerson, R Moy, P AF Tzeng, Jerome Emerson, Ryan Moy, Paul TI Composite flywheels for energy storage SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 18th Annual Technical Conference of the American-Society-for-Composites CY OCT 19-22, 2003 CL Gainesville, FL SP Amer Soc Composites DE composite flywheel; cylinder; flywheel monitor; composite ID CYLINDERS AB Composite flywheels for energy storage have been proposed and investigated for the past several decades. Successful applications are, however, limited due to the inability to predict the performance - especially the long-term durability. In this investigation, a comprehensive study was proposed with the intent to implement composites in high performance flywheels. The potential failure mechanism of flywheels constructed with fiber composites was evaluated. Analytical codes for predicting elastic and viscoelastic (long-term) behavior was developed for flywheel design. Material characterization and test matrices were proposed to design flywheels with maximum performance. Component level test methods and devices were developed to validate flywheel performance. Finally, a methodology incorporating these studies is presented for the design and manufacture of composite flywheels. (c) 2006 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Tzeng, J (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jtzeng@arl.army.mil NR 12 TC 26 Z9 31 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD NOV PY 2006 VL 66 IS 14 BP 2520 EP 2527 DI 10.1016/j.compscitech.2006.01.025 PG 8 WC Materials Science, Composites SC Materials Science GA 083VQ UT WOS:000240486700018 ER PT J AU Land, SK Wilson, B AF Land, Susan K. (Kathy) Wilson, Bret TI Using IEEE standards to support America's Army gaming development SO COMPUTER LA English DT Article C1 Northrop Grumman Informat Technol, TASC, Amer Army, Bethesda, MD 20814 USA. US Mil Acad, Off Econ Manpower & Anal, Army Game Project, West Point, NY 10996 USA. RP Land, SK (reprint author), Northrop Grumman Informat Technol, TASC, Amer Army, Bethesda, MD 20814 USA. EM susan.land@ngc.com; bret.wilson@usma.edu NR 0 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 J9 COMPUTER JI Computer PD NOV PY 2006 VL 39 IS 11 BP 105 EP 107 PG 3 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA 103SN UT WOS:000241907100013 ER PT J AU Vander Werf, EA Burt, MD Rohrer, JL Mosher, SM AF Vander Werf, Eric A. Burt, Matthew D. Rohrer, Joby L. Mosher, Stephen M. TI Distribution and prevalence of mosquito-borne diseases in O'ahu 'Elepaio SO CONDOR LA English DT Article DE Chasiempis sandwichensis; disease; 'Elepaio; Hawai'i; malaria; mosquito; pox virus ID MAUNA-LOA VOLCANO; AVIAN MALARIA; HAWAIIAN BIRDS; EPIZOOTIOLOGY; PATHOGENICITY; POX AB The endemic Hawaiian avifauna is one of the most imperiled on earth, and diseases have been one of the most serious causes of species declines. From 1995-2005, we mist-netted and banded 266 endangered O'ahu 'Elepaio (Chasiempis sandwichensis ibidis) from 27 sites, examined them for visible symptoms of avian pox virus (Poxvirus avium), and screened blood samples for avian malaria (Plasmodium relictum). Pox-like lesions and malaria were found in all 'Elepaio populations on O'ahu; no parts of the island were free of these mosquito-borne diseases. Each year, 20% +/- 4% of 'Elepaic, had active lesions likely caused by pox and an additional 16% +/- 4% had deformities and missing toes indicative of healed pox lesions. Prevalence of malaria was 87% over all years combined. Pox prevalence varied among years and was associated with annual rainfall, presumably due to greater abundance of mosquito breeding sites in wet years. Rainfall amounts at least as high as those associated with pox epizootics in 1996 and 2004 have occurred in 13 years since 1947, or once every 4.5 years. Severity of infection varied considerably among birds, and infections involving three or more toes, the feet, or the head were less common in birds with healed lesions than those with active lesions, suggesting such infections resulted in mortality more often. Disease resistance may be evolving in some areas, but 'Elepaio populations on O'ahu are likely to further decline. C1 US Fish & Wildlife Serv, Honolulu, HI 96850 USA. USA Garrison, Environm Div, Directorate Publ Works, Schofield Barracks, HI 96857 USA. RP Vander Werf, EA (reprint author), Pacific Rim Conservat, 320 Kupaua Pl, Honolulu, HI 96821 USA. EM eric@pacificrimconservation.org NR 29 TC 14 Z9 14 U1 2 U2 7 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 USA SN 0010-5422 EI 1938-5129 J9 CONDOR JI Condor PD NOV PY 2006 VL 108 IS 4 BP 770 EP 777 DI 10.1650/0010-5422(2006)108[770:DAPOMD]2.0.CO;2 PG 8 WC Ornithology SC Zoology GA 104RJ UT WOS:000241976200003 ER PT J AU Fisk, BA Jackson, WL AF Fisk, Bryan A. Jackson, William L. TI Outcomes following pneumococcal meningitis: Room for improvement remains expansive SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE dexamethasone; intensive care unit; Streptococcus pneumoniae; meningitis; penicillin; pneumococcal meningitis ID RESISTANT STREPTOCOCCUS-PNEUMONIAE; BACTERIAL-MENINGITIS; CEREBROSPINAL-FLUID; PROGNOSTIC-FACTORS; CONJUGATE VACCINE; ADULTS; CHILDREN; DEXAMETHASONE; CEFOTAXIME; DISEASE C1 Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. RP Fisk, BA (reprint author), Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD NOV PY 2006 VL 34 IS 11 BP 2853 EP 2855 DI 10.1097/01.CCM.0000240235.31535.AF PG 3 WC Critical Care Medicine SC General & Internal Medicine GA 100AQ UT WOS:000241639900025 PM 17053574 ER PT J AU Waldron, BL Robins, JG Jensen, KB Palazzo, AJ Cary, TJ Berdahl, JD AF Waldron, Blair L. Robins, Joseph G. Jensen, Kevin B. Palazzo, Antonio J. Cary, Timothy J. Berdahl, John D. TI Population and environmental effects on seed production, germination, and seedling vigor in western wheatgrass (Pascopyrum smithii [Rydb.] A. Love) SO CROP SCIENCE LA English DT Article ID RUSSIAN WILD RYEGRASS; STAND ESTABLISHMENT; CRESTED WHEATGRASS; REGISTRATION; SELECTION; EMERGENCE; WEIGHT; ORCHARDGRASS; VARIABILITY; GERMPLASM AB Western wheatgrass (Pascopyrum smithii [Rydb.] A. Love) has low seed production and poor germination and seedling vigor, limiting its use when quick establishment is needed to stabilize degraded range-lands. This study examined differences among germplasm sources and seed production environments on western wheatgrass seed traits. Seed was harvested from 10 western wheatgrass populations grown in three environments. Seed yield, seed weight, seedling germination, and seedling vigor were then determined. Seedling vigor was measured by greenhouse evaluation of seedling emergence percentage and rate from a planting depth of 6.35 cm. There were significant population X environment interactions for seed yield and seed weight. However, high Spearman's rank correlations between environments within each trait (r = 0.64 to 0.85, P = 0.048 to 0.002) suggested that environment had only a moderate effect on ranking of populations. Mean seed yield and 100-seed weight varied significantly among populations, ranging from 2.6 to 25.4 g plant(-1) and 0.43 to 0.54 g, respectively. Seed germination was high, ranging from 78.4 to 94.4%; however, population performance was not consistent across environments. Environment had no effect on seedling emergence rate, whereas emergence among populations ranged from 2.4 to 4.2 seedlings d(-1). Germination rate and seed weight were both correlated with seedling emergence rate (r = 0.57, P = 0.001 and r = 0.49, P = 0.01, respectively). These results indicated that seed production environment had little effect on western wheatgrass seed yield or seedling vigor and that it may be possible to breed for improvement in these traits by selecting among and within western wheatgrass populations. C1 Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. USA, Cold Reg Res Lab, ERDC, Hanover, NH 03755 USA. USDA ARS, No Great Plains Res Lab, Mandan, ND 58554 USA. RP Waldron, BL (reprint author), Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. EM blair.waldron@usu.edu NR 32 TC 6 Z9 7 U1 3 U2 13 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 USA SN 0011-183X J9 CROP SCI JI Crop Sci. PD NOV-DEC PY 2006 VL 46 IS 6 BP 2503 EP 2508 DI 10.2135/cropsci2006.04.0257 PG 6 WC Agronomy SC Agriculture GA 117HI UT WOS:000242863500025 ER PT J AU Larson, SR Wu, XL Jones, TA Jensen, KB Chatterton, NJ Waldron, BL Robins, JG Bushman, BS Palazzo, AJ AF Larson, Steven R. Wu, Xiaolei Jones, Thomas A. Jensen, Kevin B. Chatterton, N. Jerry Waldron, Blair L. Robins, Joseph G. Bushman, B. Shaun Palazzo, Antonio J. TI Comparative mapping of growth habit, plant height, and flowering QTLs in two interspecific families of Leymus SO CROP SCIENCE LA English DT Article ID QUANTITATIVE TRAIT LOCI; BARLEY HORDEUM-VULGARE; TAGGED SITES STSS; PHALARIS-COERULESCENS; SELF-INCOMPATIBILITY; LINKAGE MAPS; GENETIC-MAP; GENOME RELATIONSHIPS; WHEAT; RFLP AB Leymus cinereus (Scribn. & Merr.) A. Love and L. triticoides (Buckley) Pilg. are tall caespitose and short rhizomatous perennial Triticeae grasses, respectively. Circumference of rhizome spreading, proportion of bolting calms, anthesis date, and plant height were evaluated in two mapping families derived from two interspecific hybrids of L. cinereus Acc:636 and L. triticoides Acc:641 accessions, backcrossed to one L. triticoides tester. Two circumference, two bolting, and two height QTLs were homologous between families. Two circumference, seven bolting, all five anthesis date, and five height QTLs were family specific. Thus, substantial QTL variation was apparent within and between natural source populations of these species. Two of the four circumference QTLs were detected in homoeologous regions of linkage groups 3a and 3b in both families, indicating that one gene may control much of the dramatic difference in growth habit between these species. A major height QTL detected in both families may correspond with dwarfing mutations on barley 2H and wheat 2A. The L. cinereus parent contributed negative alleles for all four circumference QTLs, five of nine bolting QTLs, two of five anthesis date QTLs, and one of seven height QTLs. Coupling of synergistic QTL allele effects within parental species was consistent with the divergent growth habit and plant height of L. cinereus and L. triticoides. Conversely, antagonistic QTL alleles evidently caused transgressive segregation in reproductive bolting and flowering time. C1 Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. Univ Missouri, Columbia, MO 65211 USA. USA, Corps Engineers, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Larson, SR (reprint author), Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. EM stlarson@cc.usu.edu NR 72 TC 18 Z9 21 U1 1 U2 6 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 USA SN 0011-183X J9 CROP SCI JI Crop Sci. PD NOV-DEC PY 2006 VL 46 IS 6 BP 2526 EP 2539 DI 10.2135/cropsci2005.12.0472 PG 14 WC Agronomy SC Agriculture GA 117HI UT WOS:000242863500028 ER PT J AU Taylor, AJ Lee, HJ Sullenberger, LE AF Taylor, Allen J. Lee, Hyun J. Sullenberger, Lance E. TI The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3 SO CURRENT MEDICAL RESEARCH AND OPINION LA English DT Article; Proceedings Paper CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc DE atherosclerosis; clinical trials; lipids; risk factors ID HIGH-DENSITY-LIPOPROTEIN; ACUTE CORONARY SYNDROMES; RANDOMIZED CONTROLLED-TRIAL; CHOLESTEROL LEVELS; ARTERY-DISEASE; FOLLOW-UP; REDUCING CHOLESTEROL; SECONDARY PREVENTION; COLESTIPOL-NIACIN; HDL-CHOLESTEROL AB Objective: The ARBITER 2 trial showed that extended-release niacin (ERN) when added to statin monotherapy slowed the progression of carotid atherosclerosis over 12 months. Whether longer treatment with ERN would have a greater effect on carotid intima-media thickness (CIMT) is unknown. Research design and methods: We examined the long-term effects of ERN on high density lipoprotein (HDL-C) cholesterol and CIMT during 12 -24 months treatment with ERN in ARBITER 2 participants who were either continued or were crossed over (from placebo) to ERN 1000 mg daily. Main outcome measures: Among 149 subjects completing ARBITER 2, 130 (88%) enrolled in ARBITER 3. The prespecified primary endpoints were the within-group change in CIMT and HDL-C in patients receiving placebo for 12 months (n = 71), ERN for 12 months (comprised of subjects from ERN treatment during ARBITER 2 (n = 78) and those crossed over to ERN from placebo after ARBITER 2 (n = 47)), and ERN for 24 months spanning ARBITER 2 and 3 (n = 57). Five subjects discontinued the study due to flushing side effects. The study was completed by 104 subjects (47 crossed over from placebo; 57 with ERN continued from ARBITER 2). Results: HDL-C increased in the ERN group from 39.5 +/- 6.7 to 48.6 +/- 13.3 mg/dl (p < 0.001) along with modest reductions in LDL-C and TG. Among 125 participants treated with ERN for 12 months, there was a net regression of CIMT of -0.027 +/- 0.011 mm (p < 0.001 vs. placebo). Among 57 participants treated with ERN for 24 months, there was additional significant regression of CIMT of -0.041 +/- 0.021 mm (p = 0.001 vs. placebo). Controlling for changes in LDL and triglycerides, only changes in HDL-C were independently associated with regression of CIMT (beta = -0.25; p = 0.001). Conclusion: When added to statin therapy, ERN significantly increases HDL-C and induces atherosclerosis regression measured by CIMT over 24 months. Limitations to this study include its open-label design and the inability to relate CIMT effects to clinical outcomes. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil NR 35 TC 223 Z9 227 U1 1 U2 3 PU LIBRAPHARM PI NEWBURY PA 29-35 VENTURE WEST, NEW GREENHAM PARK, NEWBURY RG19 6HX, BERKSHIRE, ENGLAND SN 0300-7995 J9 CURR MED RES OPIN JI Curr. Med. Res. Opin. PD NOV PY 2006 VL 22 IS 11 BP 2243 EP 2250 DI 10.1185/030079906X148508 PG 8 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 103NS UT WOS:000241894300019 PM 17076985 ER PT J AU Hoyt, RW Friedl, KE AF Hoyt, Reed W. Friedl, Karl E. TI Field studies of exercise and food deprivation SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Article DE body composition; free-living; negative energy balance; physical work; semi-starvation; soldiers ID NEGATIVE-ENERGY BALANCE; DOUBLY LABELED WATER; PHYSICAL PERFORMANCE; PROLONGED EXERCISE; SLEEP-DEPRIVATION; BODY-COMPOSITION; SKELETAL-MUSCLE; SUSTAINED EXERCISE; BICYCLE EXERCISE; HEALTHY-MEN AB Purpose of review The increase in obesity in developed societies drives interest in the interplay of energy intake, metabolic energy expenditure, and body energy stores. A better understanding of energy management in physically active and undernourished humans should help guide strategies to manage obesity safely and effectively. This review focuses on field studies of men and women engaged in prolonged strenuous activities, ranging from ranger training to extreme expeditions. Recent findings Although scientifically unconventional and limited, field studies of exercise and food deprivation have yielded interesting findings: 4-5% body fat is the normal lower limit to fat reserves in physically active underfed young adult men, and in response to exercise and underfeeding, women used more fat mass and less fat-free mass to meet metabolic fuel requirements. Summary Field studies have shown that fat energy reserves in young adult men can be estimated as percentage body fat minus 5%, and initial body fat mass has a significant positive influence on fat oxidation rates per kilogram of fat-free mass during rapid weight loss associated with underfeeding and exercise. Data logging pedometers, activity monitors, global positioning systems, and wireless body and personal-area networks promise to make it easier to study and care for free-living humans. C1 USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Hoyt, RW (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Kansas St, Natick, MA 01760 USA. EM reed.hoyt@us.army.mil OI Friedl, Karl/0000-0002-3134-8427 NR 43 TC 8 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1363-1950 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD NOV PY 2006 VL 9 IS 6 BP 685 EP 690 DI 10.1097/01.mco.0000247472.72155.7c PG 6 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 104QR UT WOS:000241974200005 PM 17053420 ER PT J AU Xia, Y Gunning, ST Schulz-Butulis, BA AF Xia, Yang Gunning, Sean T. Schulz-Butulis, Beth A. TI Photo quiz - What is your diagnosis? Aquagenic syringeal acrokeratoderma (ASA) SO CUTIS LA English DT Editorial Material ID PAPULOTRANSLUCENT ACROKERATODERMA; KERATODERMA C1 Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Dermatol, Washington, DC 20307 USA. RP Xia, Y (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2006 VL 78 IS 5 BP 304 EP + PG 4 WC Dermatology SC Dermatology GA 107PH UT WOS:000242183000002 PM 17186786 ER PT J AU Parthasarathy, N DeShazer, D England, M Waag, DM AF Parthasarathy, Narayanan DeShazer, David England, Marilyn Waag, David M. TI Polysaccharide microarray technology for the detection of Burkholderia pseudomallei and Burkholderia mallei antibodies SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article; Proceedings Paper CT Meeting of the Society-for-Glycobiology CY NOV 09-12, 2005 CL Boston, MA SP Soc Glycobiol DE polysaccharide microarrays; Burkholderia pseudomallei; Burkholderia mallei; glanders; melioidosis ID SUBTRACTIVE HYBRIDIZATION; CARBOHYDRATE MICROARRAYS; VIRULENCE DETERMINANT; O-ANTIGENS; LIPOPOLYSACCHARIDE; MELIOIDOSIS; IDENTIFICATION; MUTAGENESIS; MUTANT; GENE AB A polysaccharide microarray platform was prepared by immobilizing Burkholderia pseudomallei and Burkholderia mallei polysaccharides. This polysaccharide array was tested with success for detecting B. pseudomallei and B. mallei serum (human and animal) antibodies. The advantages of this microarray technology over the current serodiagnosis of the above bacterial infections were discussed. (c) 2006 Elsevier Inc. All rights reserved. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. RP Parthasarathy, N (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. EM narayanan.parthasarathy@amedd.army.mil NR 35 TC 30 Z9 31 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD NOV PY 2006 VL 56 IS 3 BP 329 EP 332 DI 10.1016/j.diagmicrobio.2006.04.018 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 105UD UT WOS:000242056900017 PM 16765554 ER PT J AU Sun, M Srikantan, V Ma, L Li, J Zhang, W Petrovics, G Makarem, M Strovel, JW Horrigan, SG Augustus, M Sesterhenn, IA Moul, JW Chandrasekharappa, S Zou, ZQ Srivastava, S AF Sun, Mei Srikantan, Vasantha Ma, Lanfeng Li, Jia Zhang, Wei Petrovics, Gyorgy Makarem, Mazen Strovel, Jeffrey W. Horrigan, Stephen G. Augustus, Meena Sesterhenn, Isabell A. Moul, Judd W. Chandrasekharappa, Settara Zou, Zhiqiang Srivastava, Shiv TI Characterization of frequently deleted 6q locus in prostate cancer SO DNA AND CELL BIOLOGY LA English DT Article ID TUMOR-SUPPRESSOR GENE; COMPARATIVE GENOMIC HYBRIDIZATION; NONCODING RNA GENES; BREAST-CANCER; CHROMOSOME 6Q; ALLELIC LOSS; HOMEOBOX GENE; CELL-LINES; GERMLINE MUTATIONS; PROXIMAL 6Q AB The long arm of chromosome 6 is frequently deleted in diverse human neoplasms. Our previous study showed a minimum deletion region between markers D6S1056 and D6S300 on chromosome 6q in primary prostate cancer (CaP). In this study, we further refined a 200-kb minimal region of deletion (6qTSG1) centered around D6S1013 marker. The 6qTSG1 transcripts contained complex multiple splicing variants with low or absent expression in CaP cells. None of the transcripts identified contained open reading frames that code for a protein in the NCBI database. The expression of 6qTSG transcripts revealed interesting hormonal regulation relevant to CaP biology. Expression of 6q TSG transcript was induced in LNCaP cells that were cultured in charcoal-stripped serum medium suggesting an upregulation of 6qTSG transcript by androgen ablation and cell growth inhibition/apoptosis. Induction of 6qTSG1 expression in response to androgen ablation was abrogated in androgen-independent derivatives of LNCaP cells. In summary, we have defined a candidate CaP suppressor locus on chromosome 6q16.1, and deletions of this locus are frequently associated with prostate tumorigenesis. In the light of emerging role of noncoding RNAs in cancer biology including CaP, future investigations of 6qTSG11 locus is warranted. C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20832 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Serv Urol, Dept Surg, Washington, DC 20307 USA. Duke Univ, Med Ctr, Div Urol Surg, Durham, NC 27706 USA. NHGRI, NIH, Bethesda, MD 20892 USA. Avalon Pharmaceut, Germantown, MD USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20832 USA. EM ssrivastava@cpdr.or NR 80 TC 14 Z9 14 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1044-5498 J9 DNA CELL BIOL JI DNA Cell Biol. PD NOV PY 2006 VL 25 IS 11 BP 597 EP 607 DI 10.1089/dna.2006.25.597 PG 11 WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity GA 112DC UT WOS:000242504500001 PM 17132090 ER PT J AU Liu, LS Fishman, ML Hicks, KB Kende, M Ruthel, G AF Liu, LinShu Fishman, Marshall L. Hicks, Kevin B. Kende, Meir Ruthel, Gordon TI Pectin/zein beads for potential colon-specific drug delivery: Synthesis and in vitro evaluation SO DRUG DELIVERY LA English DT Article DE colon-specific drug delivery; controlled release; hydrogel; pectin; zein ID PROTEIN; CORN; ZEIN AB Novel complex hydrogel beads were prepared from two edible polymers: pectin, a carbohydrate from citrus fruits, and zein, a protein from corn. The pectin/zein complex hydrogels did not swell in physiological environments, but hydrolyzed in the presence of pectinases. An in vitro study showed the capacity of the hydrogels to endure protease attack and residence time variation. The physical and biological properties of the new hydrogels were attributed to molecular entanglement of the two polymers. The pectin networks were stabilized by the bound zein molecules. In turn, the pectin networks shielded the bound zein from protease digestion. C1 ARS, Crop Convers Sci & Engn Unit, Eastern Reg Res Ctr, USDA, Wyndmoor, PA 19038 USA. USA, Med Res Inst Infect Dis, Frederick, MD USA. GBR Ft Detrick, Frederick, MD USA. RP Liu, LS (reprint author), ARS, Crop Convers Sci & Engn Unit, Eastern Reg Res Ctr, USDA, 600 E Mermaid Lane, Wyndmoor, PA 19038 USA. EM lsliu@errc.ars.usda.gov NR 14 TC 42 Z9 47 U1 6 U2 45 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1071-7544 J9 DRUG DELIV JI Drug Deliv. PD NOV-DEC PY 2006 VL 13 IS 6 BP 417 EP 423 DI 10.1080/10717540500394935 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 087YX UT WOS:000240779800003 PM 17002969 ER PT J AU Lin, C Preston, G Calvo, E Papadopoulos, K Patnaik, A Sarantopoulos, J O'Rourke, P Takimoto, C Tolcher, A AF Lin, C. Preston, G. Calvo, E. Papadopoulos, K. Patnaik, A. Sarantopoulos, J. O'Rourke, P. Takimoto, C. Tolcher, A. TI Multi-targeted inhibition of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) pathways: a phase I study of cetuximab (C), erlotinib (E), and bevacizumab (B) in patients with solid tumors SO EJC SUPPLEMENTS LA English DT Meeting Abstract C1 Canc Res Ctr, Inst Drug Dev, San Antonio, TX USA. Brooke Army Med Ctr, Dept Hematol Oncol, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD NOV PY 2006 VL 4 IS 12 MA 198 BP 62 EP 62 DI 10.1016/S1359-6349(06)70203-8 PG 1 WC Oncology SC Oncology GA 114TM UT WOS:000242688500196 ER PT J AU Kruzelock, R Wu, WH Courage, J Short, W Dominguez, C Rodon, J Tolcher, A Takimoto, C AF Kruzelock, R. Wu, Wan-Hon Courage, J. Short, W. Dominguez, C. Rodon, J. Tolcher, A. Takimoto, C. TI Development of a 300,000 base pair custom sequencing microarray for biomarker discovery and anticancer drug development SO EJC SUPPLEMENTS LA English DT Meeting Abstract ID LUNG-CANCER; MUTATIONS; GEFITINIB; GROWTH C1 Pharmacogenom, Ctrc Inst Drug Dev, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD NOV PY 2006 VL 4 IS 12 MA 472 BP 144 EP 145 DI 10.1016/S1359-6349(06)70477-3 PG 2 WC Oncology SC Oncology GA 114TM UT WOS:000242688500467 ER PT J AU Watanaveeradej, V Endy, TP Simasathien, S Kerdpanich, A Polprasert, N Aree, C Vaughn, DW Nisalak, A AF Watanaveeradej, Veerachai Endy, Timothy P. Simasathien, Srilluck Kerdpanich, Angkooll Polprasert, Napuschon Aree, Chanchai Vaughn, David W. Nisalak, Ananda TI Transplacental chikungunya virus antibody kinetics, Thailand SO EMERGING INFECTIOUS DISEASES LA English DT Article ID DENGUE VIRUS; HEMORRHAGIC FEVER; INFECTION; CHILDREN AB Antibodies to chikungunya virus were detected by hemagglutination-inhibition assay in 33.6% of 2,000 infants' cord sera at delivery. Follow-up of 24 seropositive infants showed that the half-life of antibody persistence was 35.5 days. Chikungunya virus infection is common in Thailand, and routine use of diagnostic assays is needed. C1 Phramongkutklao Hosp, Dept Pediat, Bangkok, Thailand. Walter Reed Army Inst Res, Silver Spring, MD USA. USA, Med Res & Mat Command, Ft Detrick, MD USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Watanaveeradej, V (reprint author), Phramongkutklao Hosp, Dept Pediat, 315 Rajavithee Rd, Bangkok, Thailand. EM veerachaiw@yahoo.com NR 14 TC 10 Z9 11 U1 1 U2 1 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2006 VL 12 IS 11 BP 1770 EP 1772 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 099DY UT WOS:000241573900025 PM 17283634 ER PT J AU Geibel, NM AF Geibel, Nicholas M. TI Use of passive-diffusion bag samplers to profile low-level trichloroethene concentrations in ground-water extraction wells SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE passive-diffusion bag sampler; vertical profiling; ground-water contamination; ground-water monitoring C1 USA, Corps Engineers, Omaha, NE 68102 USA. RP Geibel, NM (reprint author), USA, Corps Engineers, Omaha Dist,106 S 15th St, Omaha, NE 68102 USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU GEOLOGICAL SOC AMERICA, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD NOV PY 2006 VL 12 IS 4 BP 361 EP 368 DI 10.2113/gseegeosci.12.4.361 PG 8 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 121WH UT WOS:000243187200006 ER PT J AU Lucio-Forster, A Bowman, DD Lucio-Martinez, B Labare, MP Butkus, MA AF Lucio-Forster, Araceli Bowman, Dwight D. Lucio-Martinez, Benjamin Labare, Michael P. Butkus, Michael A. TI Inactivation of the avian influenza virus (H5N2) in typical domestic wastewater and drinking water treatment systems SO ENVIRONMENTAL ENGINEERING SCIENCE LA English DT Article DE avian Influenza; H5N1; H5N2; UV disinfection; chlorine disinfection ID FELINE CALICIVIRUS; ADENOVIRUS TYPE-40; UV DISINFECTION; CHLORINE; BACTERIOPHAGES; RADIATION; POULTRY; SILVER AB A highly pathogenic form of avian influenza of the H5N1 subtype emerged in Hong Kong in 1997, rapidly infecting wild and domesticated birds and spread among these populations to several countries in Asia, Africa, and Europe. This virus also proved capable of infecting humans. It was hypothesized that should human-to-human transmission of such a virus become efficient, domestic wastewater and drinking water treatment systems could become contaminated with the virus, potentially exacerbating the spread of this disease. The objectives of this work were to determine if a surrogate virus, H5N2 avian influenza virus (a virus with no history of infecting humans, hereafter referred to as "H5N2") is inactivated by UV radiation, chlorination, and anaerobic digestion. Infectious H5N2 was not detected in phosphate buffer and wastewater effluent at fluences greater than 10 mJ/cm(2) and at Ct values, based on free residual chlorine, ;greater than 8 mg(.)min/L. In bench-scale anaerobic digesters, H5N2 dropped from an initial concentration of 10(3.6) EID/mL to undetectable levels after 72 h. C1 US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA. Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA. Anim HLth Diagnost Ctr, Avian Diagnost Serv, Ithaca, NY 14853 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA. EM Michael.Butkus@usma.edu NR 30 TC 8 Z9 8 U1 0 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1092-8758 J9 ENVIRON ENG SCI JI Environ. Eng. Sci. PD NOV-DEC PY 2006 VL 23 IS 6 BP 897 EP 903 DI 10.1089/ees.2006.23.897 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 104AB UT WOS:000241927200001 ER PT J AU Willens, S Stoskopf, MK Baynes, RE Lewbart, GA Taylor, SK Kennedy-Stoskopf, S AF Willens, Scott Stoskopf, Michael K. Baynes, Ronald E. Lewbart, Gregory A. Taylor, Sharon K. Kennedy-Stoskopf, Suzanne TI Percutaneous malathion absorption by anuran skin in flow-through diffusion cells SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus ID PESTICIDE EXPOSURE; FROG; INSECTICIDES; TOXICITY; TADPOLES; INVITRO; PENTACHLOROPHENOL; SUSCEPTIBILITY; SENSITIVITY; AMERICANUS AB There is increased concern about the sublethal effects of organophosphorous (OP) compounds on human and animal health, including the potential role of OP compounds in the global decline of amphibian populations. Malathion is one of the most widely used OP pesticides with numerous agricultural and therapeutic applications, and exposure to environmentally applied malathion can lead to adverse systemic effects in anurans. Cutaneous absorption is considered a potentially important route of environmental exposure to OP compounds for amphibians, especially in aquatic environments. One in vitro system commonly used to determine the absorption kinetics of xenobiotics across the skin is the two-compartment Teflon flow-through diffusion cell system. To establish cutaneous absorption kinetics of malathion, six full thickness skin samples taken from both the dorsal and ventral surfaces of each of three bullfrogs (Rana catesbeiana) and three marine toads (Bufo marinus) were placed into two-Compartment Teflon flow-through diffusion cells perfused with modified amphibian Ringer's solution. A 26 mu g/cm(2) dose of malathion-2,3-C-14-diluted in 100% ethanol was applied to each sample (0.44-0.45 mu Ci). Perfusate was collected at intervals over a 6 h period and analyzed for C-14 in a scintillation counter. At the end of 6 h, surface swabs, tape strips, biopsy punches of the dosed area of skin, and peripheral samples were oxidized and analyzed for residue effects. Malathion absorption was greater across the ventral skin compared to dorsal skin in both bullfrogs and marine toads. (c) 2006 Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Coll Vet Med, Environm Med Consortium, Raleigh, NC 27606 USA. US EPA, Natl Ctr Environm Assessment Washington, DC Div, Res Triangle Pk, NC 27711 USA. RP Willens, S (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM scott.willens@amedd.army.mil NR 42 TC 12 Z9 12 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1382-6689 J9 ENVIRON TOXICOL PHAR JI Environ. Toxicol. Pharmacol. PD NOV PY 2006 VL 22 IS 3 BP 255 EP 262 DI 10.1016/j.etap.2006.04.010 PG 8 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA 099TB UT WOS:000241617700002 PM 21783718 ER PT J AU Willens, S Stoskopf, MK Baynes, RE Lewbart, GA Taylor, SK Kennedy-Stoskopf, S AF Willens, Scott Stoskopf, Michael K. Baynes, Ronald E. Lewbart, Gregory A. Taylor, Sharon K. Kennedy-Stoskopf, Suzanne TI Percutaneous malathion absorption in the harvested perfused anuran pelvic limb SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE organophosphorous; pesticide; bullfrog; Rana catesbeiana; marine toad; Bufo marinus ID PORCINE SKIN FLAP; FROG-SKIN; MODEL AB The objective of this study was to establish an accurate in vitro model for cutaneous absorption in anurans. The harvested perfused anuran pelvic limb (HPAPL) model maintains the anatomic and physiologic integrity of the skin from the pelvic limb, including the intact capillary network. Radiolabeled malathion was applied to the skin of the dorsal thigh, and perfusate was collected over a 6 h period. Residues from the skin surface, stratum externum, and dosed area beneath the stratum externum were analyzed. Kinetic parameters were calculated from these data. Absorption was significantly less for the HPAPL than previously reported for Teflon flow-through diffusion cells. However, partitioning effects were comparable. The HPAPL is an appropriate in vitro model for examining cutaneous absorption kinetics in the bullfrog. (c) 2006 Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Coll Vet Med, Environm Med Consortium, Raleigh, NC 27606 USA. US EPA, Natl Ctr Environm Assessment, Washington DC Div, Res Triangle Pk, NC 27711 USA. RP Willens, S (reprint author), USA, Med Res Inst Chem Def, 3100 Rickets Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM scott.willens@amedd.army.mil NR 24 TC 3 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1382-6689 J9 ENVIRON TOXICOL PHAR JI Environ. Toxicol. Pharmacol. PD NOV PY 2006 VL 22 IS 3 BP 263 EP 267 DI 10.1016/j.etap.2006.04.009 PG 5 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA 099TB UT WOS:000241617700003 PM 21783719 ER PT J AU Smith, JR Capacio, BR AF Smith, J. Richard Capacio, Benedict R. TI Laboratory analysis of biomedical samples for the verification of chemical warfare agent exposure SO EPIDEMIOLOGY LA English DT Meeting Abstract CT ISEE/ISEA 2006 Conference CY 2006 CL Paris, FRANCE SP ISEE, ISEA C1 US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2006 VL 17 IS 6 SU S BP S27 EP S27 DI 10.1097/00001648-200611001-00025 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 097JL UT WOS:000241443400025 ER PT J AU Kuperman, RG Amorim, MJB Rombke, J Lanno, R Checkai, RT Dodard, SG Sunahara, GI Scheffczyk, A AF Kuperman, R. G. Amorim, M. J. B. Rombke, J. Lanno, R. Checkai, R. T. Dodard, S. G. Sunahara, G. I. Scheffczyk, A. TI Adaptation of the enchytraeid toxicity test for use with natural soil types SO EUROPEAN JOURNAL OF SOIL BIOLOGY LA English DT Article; Proceedings Paper CT 14th International Colloquium on Soil Zoology - Soil Animals and Ecosystems Services CY AUG 30-SEP 03, 2004 CL Univ Rouen, Mt St Aignan, FRANCE HO Univ Rouen DE enchytraeid toxicity test; natural soils; standard soils; EURO soils ID REPRODUCTION TEST; SPECIES OLIGOCHAETA; EARTHWORM TOXICITY; ALBIDUS; CHEMICALS; PHENMEDIPHAM AB Assessments of chemical toxicity to soil invertebrates have been traditionally performed in formulated Standard Artificial Soil, or in standard LUFA 2.2 natural soil. Physical and chemical properties of these standard soils often do not represent the diversity of properties of natural soils and can be inadequate surrogates of exposure conditions of soil biota in the field. We investigated performance of three species of the genus Enchytraeus (E. albidus, E. crypticus, E. luxuriosus) using soil types covering a wide range of European and North American soil properties. Results showed that adult survival and juvenile production by E. albidus and E. luxuriosus were inhibited in acidic soils with pH <= 5, while less acidic soils having properties within following ranges: 2.5-8.0% OM; 6-26% clay, and 4-80% sand, could sustain survival and reproduction at or near validity criteria levels of enchy-traeid toxicity test ISO/16387. Performance of E. crypticus in North American soils having properties within following ranges: 1.2-42% OM, 1-29% clay, and 4.4-8.2 pH, met or exceeded all validity criteria. Data established in our studies can be used for amending the validity criteria of current ISO/16387 when used with E. crypticus and OECD soil. Published by Elsevier Masson SAS. C1 USA, Edgewood Chem Biol Ctr, AMSRD ECB RT TE, Aberdeen Proving Ground, MD 21010 USA. RP Kuperman, RG (reprint author), USA, Edgewood Chem Biol Ctr, AMSRD ECB RT TE, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM roman.kuperman@us.army.mil RI Kuperman, Roman/D-4297-2009; Amorim, Monica/G-8590-2011; OI Amorim, Monica/0000-0001-8137-3295; Rombke, Jorg/0000-0003-1341-634X NR 46 TC 17 Z9 18 U1 1 U2 11 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 1164-5563 J9 EUR J SOIL BIOL JI Eur. J. Soil Biol. PD NOV PY 2006 VL 42 SU 1 BP S234 EP S243 DI 10.1016/j.ejsobi.2006.07.028 PG 10 WC Ecology; Soil Science SC Environmental Sciences & Ecology; Agriculture GA 122YP UT WOS:000243263800033 ER PT J AU Seehusen, DA Miser, WF AF Seehusen, Dean A. Miser, William F. TI Teaching the outstanding medical learner SO FAMILY MEDICINE LA English DT Article ID GIFTED ADULTS; ISSUES AB Medical students and residents are typically prescribed a standardized curriculum. Learners who have difficultly meeting requirements of this curriculum often require extra attention and an individualized program of remediation. Outstanding medical learners, on the other hand, are rarely given an individualized learning program, even if they can easily master the standardized curriculum. These learners are likely to belong to a group that educators call "gifted adults. " No literature on this group of medical learners currently exists, and no research has been conducted on them. This article is designed to begin a dialog on the best approach to educating outstanding medical learners using the framework of the gifted adult. Gifted adults possess a unique set of characteristics and have needs that set them apart from the majority of medical learners. There are also well-described pitfalls that these learners encounter. Gifted adults can best exercise their talents and maximize their potential when they receive an individualized educational approach that focuses on providing intellectual challenges with permission to explore interest areas. Research, publishing, teaching opportunities, and leadership roles are some examples of ways to challenge these learners. They should be strongly encouraged to extensively pursue individual interests. Effort should be made to ensure that these learners have contact with peers and mentors of equal intellectual abilities. Gifted adults who are not intellectually stimulated on a routine basis and are not able to interact with other talented individuals may get bored and frustrated with their education. Medical educators who understand the characteristics and drives of gifted adults will be better able to ensure that these learners are regularly challenged, with needed assistance to avoid common pitfalls. C1 Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA 30905 USA. Ohio State Univ, Dept Family Med, Columbus, OH 43210 USA. RP Seehusen, DA (reprint author), Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA 30905 USA. EM dseehusen@msn.com RI Miser, William/E-3686-2011 NR 18 TC 4 Z9 4 U1 0 U2 1 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 J9 FAM MED JI Fam. Med. PD NOV-DEC PY 2006 VL 38 IS 10 BP 731 EP 735 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 186SR UT WOS:000247799000012 PM 17075747 ER PT J AU Reitstetter, RE AF Reitstetter, Raven E. TI Development of species-specific PCR primer sets for the detection of Leptospira SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Leptospira; leptospirosis; species-specific PCR primers; species identification ID PATHOGENIC LEPTOSPIRES; QUANTITATIVE PCR; SEROVARS; IDENTIFICATION; ASSAY; DIFFERENTIATION; PREVALENCE; HUMANS AB Spirochetes of the genus Leptospira infect animals and humans and are the causative agents for the emerging infectious disease leptospirosis. Rapid and simple assays for the identification of individual Leptospira species are currently not available. For identification of individual Leptospira species, PCR primers that detect the ompL1 gene sequence for the majority of pathogenic leptospires were developed in this study. The primer pairs detect Leptospira interrogans, Leptospira borgpetersenii, Leptospira kirschneri, Leptospira santarosai, Leptospira weilii and Leptospira noguchii, without cross-reacting with other Leptospira species. The development of the primers revealed a divergence of the ompL1 gene within L. interrogans, splitting this species into two separate groups. The species-specific primers will be especially useful in epidemiological studies and disease outbreak investigations for the detection of Leptospira species in human, animal and environmental samples. C1 Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Reitstetter, RE (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave,Suite A, Ft Sam Houston, TX 78234 USA. EM raven.reitstetter@amedd.army.mil OI Reitstetter, Raven/0000-0002-7466-9781 NR 30 TC 16 Z9 18 U1 2 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0378-1097 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD NOV PY 2006 VL 264 IS 1 BP 31 EP 39 DI 10.1111/j.1574-6968.2006.00431.x PG 9 WC Microbiology SC Microbiology GA 089ZG UT WOS:000240919800005 PM 17020546 ER PT J AU Lee, SJ Reddy, JN Rostam-Abadi, F AF Lee, S. J. Reddy, J. N. Rostam-Abadi, F. TI Nonlinear finite element analysis of laminated composite shells with actuating layers SO FINITE ELEMENTS IN ANALYSIS AND DESIGN LA English DT Article DE finite element analysis; laminated composite structures; Sanders shell theory; third-order shear deformation theory; smart materials; deflection control ID SENSING MAGNETOSTRICTIVE ACTUATOR; SHEAR DEFORMATION-THEORY; VIBRATION SUPPRESSION; MINI-ACTUATORS; BEAMS AB Nonlinear finite element analysis of laminated composite shell structures with smart material laminae is presented in the study. Third-order shear deformation theory based on Sanders nonlinear shell kinematics is chosen for the shell formulation and it is used to study deflection suppression characteristics of laminated composite shells. The smart material used in this study to achieve damping of transverse deflection is a magnetostrictive material, Terfenol-D, with a linear constitutive model. A negative velocity feedback control is used with a constant control gain. Newmark's time integration scheme and Newton-Raphson iteration method are used to solve the resulting nonlinear equations. A number of parametric studies are carried out to understand the damping characteristics of laminated composite shells with embedded smart material layers. (c) 2006 Published by Elsevier B.V. C1 Texas A&M Univ, Dept Civil Engn, College Stn, TX 77843 USA. Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. USA, Tank AutomotiveTank & Armaments Command, AMSTA TR R, Warren, MI 48397 USA. RP Reddy, JN (reprint author), Texas A&M Univ, Dept Civil Engn, College Stn, TX 77843 USA. EM Jnreddy@shakti.tamu.edu NR 28 TC 19 Z9 19 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-874X J9 FINITE ELEM ANAL DES JI Finite Elem. Anal. Des. PD NOV PY 2006 VL 43 IS 1 BP 1 EP 21 DI 10.1016/j.finel.2006.04.008 PG 21 WC Mathematics, Applied; Mechanics SC Mathematics; Mechanics GA 100YZ UT WOS:000241707400001 ER PT J AU Franssen, NR Gido, KB Guy, CS Tripe, JA Shrank, SJ Strakosh, TR Bertrand, KN Franssen, CM Pitts, KL Paukert, CP AF Franssen, Nathan R. Gido, Keith B. Guy, Christopher S. Tripe, Jeff A. Shrank, Sally J. Strakosh, Timothy R. Bertrand, Katie N. Franssen, Courtney M. Pitts, Kristen L. Paukert, Craig P. TI Effects of floods on fish assemblages in an intermittent prairie stream SO FRESHWATER BIOLOGY LA English DT Article DE colonisation; drought; fish dispersal; stream connectivity; temporal variation ID COMMUNITY STRUCTURE; TEMPORAL PATTERNS; HEADWATER STREAMS; OZARK STREAM; HABITAT; VARIABILITY; ORGANIZATION; RESISTANCE; STABILITY; MOVEMENT AB 1. Floods are major disturbances to stream ecosystems that can kill or displace organisms and modify habitats. Many studies have reported changes in fish assemblages after a single flood, but few studies have evaluated the importance of timing and intensity of floods on long-term fish assemblage dynamics. 2. We used a 10-year dataset to evaluate the effects of floods on fishes in Kings Creek, an intermittent prairie stream in north-eastern, Kansas, U.S.A. Samples were collected seasonally at two perennial headwater sites (1995-2005) and one perennial downstream flowing site (1997-2005) allowing us to evaluate the effects of floods at different locations within a watershed. In addition, four surveys during 2003 and 2004 sampled 3-5 km of stream between the long-term study sites to evaluate the use of intermittent reaches of this stream. 3. Because of higher discharge and bed scouring at the downstream site, we predicted that the fish assemblage would have lowered species richness and abundance following floods. In contrast, we expected increased species richness and abundance at headwater sites because floods increase stream connectivity and create the potential for colonisation from downstream reaches. 4. Akaike Information Criteria (AIC) was used to select among candidate regression models that predicted species richness and abundance based on Julian date, time since floods, season and physical habitat at each site. At the downstream site, AIC weightings suggested Julian date was the best predictor of fish assemblage structure, but no model explained > 16% of the variation in species richness or community structure. Variation explained by Julian date was primarily attributed to a long-term pattern of declining abundance of common species. At the headwater sites, there was not a single candidate model selected to predict total species abundance and assemblage structure. AIC weightings suggested variation in assemblage structure was associated with either Julian date or local habitat characteristics. 5. Fishes rapidly colonised isolated or dry habitats following floods. This was evidenced by the occurrence of fishes in intermittent reaches and the positive association between maximum daily discharge and colonisation events at both headwater sites. 6. Our study suggests floods allow dispersal into intermittent habitats with little or no downstream displacement of fishes. Movement of fishes among habitats during flooding highlights the importance of maintaining connectivity of stream networks of low to medium order prairie streams. C1 Kansas State Univ, Dept Biol, Manhattan, KS 66506 USA. Montana State Univ, Dept Ecol, Montana Cooperat Fishery Res Unit, US Geol Survey, Bozeman, MT 59717 USA. USA, Corps Engineers, Ft Worth Dist, TX USA. Univ Oklahoma, Dept Zool, Norman, OK 73019 USA. Kansas State Univ, Kansas Cooperat Fish & Wildlife Res Unit, US Geol Survey, Manhattan, KS 66506 USA. RP Franssen, NR (reprint author), Sam Noble Oklahoma Museum Nat Hist, 2401 Chautaugua Ave, Norman, OK 73072 USA. EM nrfranssen@gmail.com RI Bertrand, Katie/A-5902-2012; Gido, Keith/B-5151-2013; OI Bertrand, Katie/0000-0001-8453-6758; Bouska, Kristen/0000-0002-4115-2313 NR 44 TC 46 Z9 47 U1 1 U2 22 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0046-5070 J9 FRESHWATER BIOL JI Freshw. Biol. PD NOV PY 2006 VL 51 IS 11 BP 2072 EP 2086 DI 10.1111/j.1365-2427.2006.01640.x PG 15 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 093TA UT WOS:000241190900008 ER PT J AU Luttwak, EN AF Luttwak, Edward N. TI Preserving balance among the great powers SO FUTURIST LA English DT Article C1 USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD FUTURE SOCIETY PI BETHESDA PA 7910 WOODMONT AVE, SUITE 450, BETHESDA, MD 20814 USA SN 0016-3317 J9 FUTURIST JI Futurist PD NOV-DEC PY 2006 VL 40 IS 6 BP 26 EP 26 PG 1 WC Social Issues SC Social Issues GA 093WT UT WOS:000241201700019 ER PT J AU Arcone, SA Finnegan, DC Liu, LB AF Arcone, Steven A. Finnegan, David C. Liu, Lanbo TI Target interaction with stratigraphy beneath shallow, frozen lakes: Quarter-wave resonances within GPR profiles SO GEOPHYSICS LA English DT Article ID SHORT-PULSE RADAR; RIVER AB Resonances within ground-penetrating radar (GPR) reflection profiles recorded over shallow, frozen lakes located on an artillery and bombing range in interior Alaska originate near ice/bottom and freeze/thaw interface horizons and are similar to those caused by shallow utilities. The transmitted pulse spectra were centered near 280 MHz. Low-pass filtering differentiates the resonances from background scattering. The transit times between their onset and that of the overlying interface reflections correspond with spectral peaks predicted for layers with thickness of one in-situ quarter-wavelength, which we call quarter-wave resonance. The peaks are below 160 MHz, which is well below the transmitted pulse bandwidth and may occur as a modulation of a reflection sequence. Although the transit times cannot resolve both layer thickness and permittivity, reasonable values of permittivity give overburden layers above the targets on the order of 10 cm, which is consistent with the persistence of the resonances. Numerical models of metal objects beneath an interface between materials of strong permittivity contrast reveal that significant energy at the predicted frequencies requires cylinder diameters too large to be ordnance. However, strong resonances at the predicted frequencies result from flat metal sheets of 0.5-1 m dimension, and so we interpret the resonances to be caused by nonhazardous targets. Late winter is an ideal time to survey for targets in this area because the ice affords repeatable positioning for the antennas and thermal high-dielectric-contrast interfaces are then well developed. The bandwidth of the pulse we used appears ideally suited for both resolution of the shallow strata and detection of the resonances, thereby allowing the resonances to be checked against quarter-wave theory. C1 USA, ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Univ Connecticut, Dept Civil & Environm Engn, U2037, Storrs, CT 06269 USA. RP Arcone, SA (reprint author), USA, ERDC Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM steven.a.arcone@erdc.usace.army.mil; david.finnegan@erdc.usace.army.mil; lanbo.liu@uconn.edu NR 25 TC 7 Z9 7 U1 0 U2 2 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD NOV-DEC PY 2006 VL 71 IS 6 BP K119 EP K131 DI 10.1190/1.2358404 PG 13 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 113LE UT WOS:000242598600035 ER PT J AU Hestholm, S Moran, M Ketcham, S Anderson, T Dillen, M McMechan, G AF Hestholm, Stig Moran, Mark Ketcham, Stephen Anderson, Thomas Dillen, Meindert McMechan, George TI Effects of free-surface topography on moving-seismic-source modeling SO GEOPHYSICS LA English DT Article ID BOUNDARY-CONDITION; HALF-SPACE; DIFFERENCE; 3-D; MOTION AB A curved-grid velocity-stress formulation for viscoelastic wave modeling is used with an arbitrary number of relaxation mechanisms to model a desired Q-behavior. These equations are discretized by high-order staggered, finite differences (FDs) in the interior of the medium, and we gradually reduce the FD order to two at the stress-free surface, where we implement our boundary conditions for an arbitrary topographic surface. A moving source is simulated along the surface of a relatively general and locally steep surface topography and, for comparison, along a plane surface. The topography consists of a significant hill surrounded by a valley. Similar two-layered geologic models are used with both topographic surfaces, with the upper layer being a lossy sedimentary layer having a relatively strong contrast with the lower, higher-velocity half-space. Local topographic highs create varying amplitude amplifications at different times during motion of the source. A pronounced wavefield accumulation is evident at the topographic highs in all components. This is very different from the even pattern produced by the same source along the same path for the plane topographic surface, even in the presence of the strong material discontinuity between the two geologic layers. The effect is, however, similar to real records for nonmoving sources of long duration; over time, the direction of incidence becomes less significant, and amplitude amplification occurs in all directions for waves trapped in a topographic high. These spatial focusing effects should be taken into account in inversion for vehicle tracking to avoid target mislocation and/or misidentification. C1 Univ Texas, Ctr Lithospher Studies, Richardson, TX 75083 USA. USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Hestholm, S (reprint author), Shell E&P Technol Ctr, 3737 Bellaire Blvd, Houston, TX 77002 USA. EM stig.hestholm@shell.com; mark.l.moran@erdc.usace.army.mil; stephen.a.ketchan@erdc.usace.army.mil; thomas.anderson@crrel.usace.army.mil; meno.dillen@iku.sintef.no; mcmec@utdallas.edu NR 24 TC 8 Z9 8 U1 1 U2 2 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD NOV-DEC PY 2006 VL 71 IS 6 BP T159 EP T166 DI 10.1190/1.2356258 PG 8 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 113LE UT WOS:000242598600055 ER PT J AU Parthasarathy, N DeShazer, D England, MJ Amit, J Sharan, V Waag, DM AF Parthasarathy, Narayanan DeShazer, David England, Marilyn J. Amit, Jain Sharan, VedBrat Waag, David M. TI Polysaccharide microarray technology for the serodiagnosis of Burkholderia mallei infection in horses SO GLYCOBIOLOGY LA English DT Meeting Abstract CT Meeting of the Society-for-Gylcobiology CY NOV 15-19, 2006 CL Universal City, CA SP Soc Gylcobiol C1 USA, MRIID, Frederick, MD 21702 USA. KamTek Inc, Gaithersburg, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD NOV PY 2006 VL 16 IS 11 MA 163 BP 1135 EP 1135 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 092JR UT WOS:000241093300169 ER PT J AU Becker, D Minsker, B Greenwald, R Zhang, Y Harre, K Yager, K Zheng, CM Peralta, R AF Becker, David Minsker, Barbara Greenwald, Robert Zhang, Yan Harre, Karla Yager, Kathleen Zheng, Chunmiao Peralta, Richard TI Reducing long-term remedial costs by transport modeling optimization SO GROUND WATER LA English DT Article AB The Department of Defense (DoD) Environmental Security Technology Certification Program and the Environmental Protection Agency sponsored a project to evaluate the benefits and utility of contaminant transport simulation-optimization algorithms against traditional (trial and error) modeling approaches. Three pump-and-treat facilities operated by the DoD were selected for inclusion in the project. Three optimization formulations were developed for each facility and solved independently by three modeling teams (two using simulation-optimization algorithms and one applying trial-and-error methods). The results clearly indicate that simulation-optimization methods are able to search a wider range of well locations and flow rates and identify better solutions than current trial-and-error approaches. The solutions found were 5% to 50% better than those obtained using trial-and-error (measured using optimal objective function values), with an average improvement of similar to 20%. This translated into potential savings ranging from $600,000 to $10,000,000 for the three sites. In nearly all cases, the cost savings easily outweighed the costs of the optimization. To reduce computational requirements, in some cases the simulation-optimization groups applied multiple mathematical algorithms, solved a series of modified subproblems, and/or fit "meta-models" such as neural networks or regression models to replace time-consuming simulation models in the optimization algorithm. The optimal solutions did not account for the uncertainties inherent in the modeling process. This project illustrates that transport simulation-optimization techniques are practical for real problems. However, applying the techniques in an efficient manner requires expertise and should involve iterative modification to the formulations based on interim results. C1 USA, Corps Engineers, Hazardous Tox & Radioact Waste Ctr Expertise, Omaha, NE 68144 USA. Minsker Consulting, Champaign, IL 61821 USA. GeoTrans Inc, Freehold, NJ 07728 USA. USN, Naval Facilities Engn Serv Ctr, Code ESC414, Port Hueneme, CA 93043 USA. US EPA, Off Superfund Remediat & Technol Innovat, ECA OEME, North Chelmsford, MA 01863 USA. Univ Alabama, Dept Geol Sci, Tuscaloosa, AL 35487 USA. Utah State Univ, Dept Biol & Irragat Engn, Logan, UT 84322 USA. RP Becker, D (reprint author), USA, Corps Engineers, Hazardous Tox & Radioact Waste Ctr Expertise, 12565 W Ctr Rd, Omaha, NE 68144 USA. EM dave.j.becker@usace.army.mil RI Zheng, Chunmiao/I-5257-2014 OI Zheng, Chunmiao/0000-0001-5839-1305 NR 23 TC 22 Z9 22 U1 1 U2 9 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0017-467X J9 GROUND WATER JI Ground Water PD NOV-DEC PY 2006 VL 44 IS 6 BP 864 EP 875 DI 10.1111/j.1745-6584.2006.00242.x PG 12 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA 099UU UT WOS:000241622600014 PM 17087758 ER PT J AU Farley, JH Truong, V Goo, E Uyehara, C Belnap, C Larsen, WI AF Farley, John H. Truong, Vu Goo, Elwin Uyehara, Catherine Belnap, Christina Larsen, Wilma I. TI A randomized double-blind placebo-controlled phase II trial of the cyclooxygenase-2 inhibitor Celecoxib in the treatment of cervical dysplasia SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 39th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 31-JUN 03, 2003 CL CHICAGO, IL SP Amer Soc Clin Oncol DE Celecoxib; cervix; dysplasia; medical therapy ID HUMAN PAPILLOMAVIRUS INFECTION; TERM FOLLOW-UP; COLON CARCINOGENESIS; COLORECTAL-CANCER; NATURAL-HISTORY; CELL-LINES; EXPRESSION; CHEMOPREVENTION; CARCINOMAS; RECURRENCE AB Objectives. The objective of the study was to evaluate the efficacy of daily Celecoxib in the regression of moderate and severe cervical dysplasia, when compared to placebo. Materials and methods. Women, over the age of 18, with the histologic diagnosis of moderate or severe cervical dysplasia were enrolled in this IRB approved study. Women were randomized to receive either Celecoxib 200 mg twice a day or placebo. Both examining physician and patients were blinded to treatment option. Follow-up colposcopy with cervical cytology was obtained at 2-month intervals for 6 months, with cytologic and histologic specimens. Results. From June 2002 until October 2003, a total of 25 patients were enrolled in this randomized phase II study. There was no statistical difference in screening entry criteria, clinical histologic and cytologic variables between the two groups. 60% of patients enrolled had an overall response in the trial. The mean time to response was 72 days. 75% of patients who received Celecoxib had a clinical response. This was significantly higher than the 31%, of the placebo patients that had a clinical response, P < 0.03. 33% of patients in the Celecoxib group had complete pathologic response to therapy, which was higher than the placebo group 15%. Conclusion. We have observed that Celecoxib could have activity in the treatment of high-grade cervical dysplasia. As a result, medical treatment of cervical dysplasia with Celecoxib could offer a minimally invasive treatment with minor morbidity and time constraints. Further trials with larger numbers are needed to confirm these results. Published by Elsevier Inc. C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pharm, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Farley, JH (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 1 Jarrett White Rd TAMC, Honolulu, HI 96859 USA. EM john.farley@us.army.mil NR 31 TC 14 Z9 16 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2006 VL 103 IS 2 BP 425 EP 430 DI 10.1016/j.ygyno.2006.03.036 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 101SA UT WOS:000241759600008 PM 16677697 ER PT J AU Maxwell, GL Schildkraut, JM Calingaert, B Risinger, JI Dainty, L Marchbanks, PA Berchuck, A Barrett, JC Rodriguez, GC AF Maxwell, G. L. Schildkraut, J. M. Calingaert, B. Risinger, J. I. Dainty, L. Marchbanks, P. A. Berchuck, A. Barrett, J. C. Rodriguez, G. C. TI Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 35th Annual Meeting of the Society-of-Gynecologic-Oncologists CY FEB 07-11, 2004 CL San Diego, CA SP Soc Gynecol Oncol DE endometrial cancer; oral contraceptives ID OVARIAN-CANCER; OVERWEIGHT; CARCINOMA; OBESITY; WOMEN AB Objective. Using data from a case-control study of endometrial cancer, we investigated the relationship between the progestin and estrogen potency in combination oral contraceptives (OCs) and the risk of developing endometrial cancer. Methods. Subjects included 434 endometrial cancer cases and 2557 controls identified from the Cancer and Steroid Hormone (CASH) study. OCs were classified into four categories according to the individual potencies of each hormonal constituent (high versus low estrogen or progestin potency). Logistic regression was used to evaluate associations between endometrial cancer risk and combination OC formulations. Results. With non-users as the referent group, use of OCs with either high potency progestin [odds ratio for endometrial cancer (OR)=0.21, 95% confidence interval (CI)=0.10 to 0.43] or with low potency progestin (OR=0.39, 95% CI=0.25 to 0.60) were both associated with a decreased risk of endometrial cancer. Overall high progestin potency OCs did not confer significantly more protection than low progestin potency OCs (OR=0.52, 95% CI=0.24 to 1.14). However, among women with a body mass index of 22.1 kg/m(2) or higher, those who used high progestin potency oral contraceptives had a lower risk of endometrial cancer than those who used low progestin potency oral contraceptives (OR=0.31, 95% CI=0.11 to 0.92) while those with a BMI below 22.1 kg/m(2) did not (OR=1.36, 95% CI=0.39 to 4.70). Conclusion. The potency of the progestin in most OCs appears adequate to provide a protective effect against endometrial cancer. Higher progestin-potency OCs may be more protective than lower progestin potency OCs among women with a larger body habitus. Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. US Mil Canc Inst, Washington, DC 20307 USA. Duke Univ, Med Ctr, Dept Family & Community Med, Div Canc Control, Durham, NC 27710 USA. Duke Univ, Med Ctr, Div Gynecol Oncol, Durham, NC 27710 USA. NCI, Ctr Canc Res, Bethesda, MD 20892 USA. Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. Northwestern Univ, Evanston NW Healthcare, Div Gynecol Oncol, Evanston, IL 60201 USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, 6900 Georgia Ave, Washington, DC 20307 USA. EM george.maxwell@na.amedd.arymy.mil FU NICHD NIH HHS [3-Y01-HD-8-1037] NR 20 TC 31 Z9 33 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2006 VL 103 IS 2 BP 535 EP 540 DI 10.1016/j.ygyno.2006.03.046 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 101SA UT WOS:000241759600028 PM 16740300 ER PT J AU Farley, J Birrer, MJ Christian, MC AF Farley, John Birrer, Michael J. Christian, Michaele C. TI The future of phase II trials SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT Ovarian Cancer State of the Science Meeting CY SEP 15-17, 2005 CL Rockville, MD SP AstraZeneca, Cti, Eli Lilly & Co, MGi Pharma, OSI Pharmacrut, NCI Office Ctr, Training, & Resources, & Gynecol Oncol Grp, Sanofi Aventis Pharmaceut, TriPath Imaging Inc, ABRAXIS Oncol, Cell Therapeut Inc AB Topics: How to complete phase II trials faster; stratification of patients in phase II trials, response end points; competition between NCI-sponsored and industry-sponsored phase II trials for patients. C1 Tripler Army Med Ctr, Div Gynecol Oncol, Honolulu, HI 96859 USA. NCI, Cell & Canc Biol Dept, Med Branch, Ctr Canc Res, Rockville, MD 20850 USA. NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA. RP Farley, J (reprint author), Tripler Army Med Ctr, Div Gynecol Oncol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.farley@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2006 VL 103 IS 2 SU 1 BP S20 EP S22 DI 10.1016/j.ygyno.2006.08.021 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 102XZ UT WOS:000241848200006 PM 17027074 ER PT J AU Gustofson, RL Segars, JH Larsen, FW AF Gustofson, Robert L. Segars, James H. Larsen, Frederick W. TI Ganirelix acetate causes a rapid reduction in estradiol levels without adversely affecting oocyte maturation in women pretreated with leuprolide acetate who are at risk of ovarian hyperstimulation syndrome SO HUMAN REPRODUCTION LA English DT Article DE cycle cancellation; estradiol; ganirelix acetate; GnRH agonist and antagonist; OHSS ID IN-VITRO FERTILIZATION; FOLLICLE-STIMULATING-HORMONE; GNRH ANTAGONIST GANIRELIX; SERUM ESTRADIOL; ELECTIVE CRYOPRESERVATION; LUTEINIZING-HORMONE; PRONUCLEATE EMBRYOS; FEMALE FECUNDITY; PREGNANCY RATES; GONADOTROPIN AB BACKGROUND: Elevated estradiol (E-2) levels predispose to development of ovarian hyperstimulation syndrome (OHSS). Since GnRH antagonist is associated with a reduction in E-2 levels, we hypothesized that GnRH-antagonist treatment of women down-regulated with GnRH agonist who are at risk of OHSS might reduce E-2 levels and avoid cycle cancellation. METHODS: Retrospective study in a university-based assisted reproduction technology (ART) programme in 87 patients treated with long luteal (LL) or microdose flare (MDF) with ovarian hyperresponse and 87 control patients without ovarian hyperresponse. GnRH-antagonist (ganirelix acetate) treatment was started and leuprolide acetate discontinued in women who failed to respond to a reduction in gonadotrophin dosage. RESULTS: In the treatment group, there was a significant, reproducible reduction in serum E-2 levels. Mean E-2 at the start of ganirelix treatment was 4219.8 pg/ml and decreased in 24 h to 2613.7 pg/ml (36.7%; P < 0.001). An average of 24.9 +/- 8.8 oocytes were obtained at retrieval and an average of 19.1 +/- 8.0 were metaphase II (79.2%). Fertilization occurred in 13.9 +/- 8.1 embryos (72.8%). In this high risk group, two cases of severe OHSS (2.3%) occurred. The ongoing pregnancy rate was 51.8%. Compared with the control group, there were no statistically significant differences in the rate of oocyte recovery, oocyte maturity, 2PN rate, fertilization, cancellation, OHSS or pregnancy. CONCLUSIONS: GnRH-antagonist treatment of women pretreated with GnRH agonist rapidly reduced circulating serum E-2 without adversely affecting oocyte maturation, fertilization rates or embryo quality and resulted in a high pregnancy rate in this subgroup of patients at risk of OHSS. C1 Walter Reed Army Med Ctr, Assisted Reprod Technol Program, Washington, DC 20307 USA. NIH, Combined Fed Fellowship Reprod Endocrinol & Infer, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. RP Larsen, FW (reprint author), Walter Reed Army Med Ctr, Assisted Reprod Technol Program, 6900 Georgia Ave NW,Ward 43, Washington, DC 20307 USA. EM frederick.larsen@na.amedd.army.mil FU Intramural NIH HHS NR 48 TC 17 Z9 17 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD NOV PY 2006 VL 21 IS 11 BP 2830 EP 2837 DI 10.1093/humrep/del059 PG 8 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 094XO UT WOS:000241272700015 PM 16966348 ER PT J AU Chinn, SR King, V AF Chinn, Stephen R. King, Vernon TI Subnanosecond (Er,Yb) glass Q-switched microlasers: 3-D transient modeling and experiments SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE finite difference methods; laser resonators; optical pulses; rare earth compounds; solid lasers ID LASERS AB We present a new 3-D transient model and new experimental data for Q-switched eyesafe microlasers based on (Er,Yb) glass with a Co2+:spinel saturable absorber. Sulmanosecond pulses have been achieved for the first time using shorter, more highly doped laser glass. The model gives reasonable agreement with data for different Er3+ concentrations and cavity lengths, using only published or measured input parameters. C1 USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Chinn, SR (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM steve.chinn@nvl.army.mil NR 10 TC 6 Z9 6 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD NOV-DEC PY 2006 VL 42 IS 11-12 BP 1128 EP 1136 DI 10.1109/JQE.2006.883470 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 114TV UT WOS:000242689400004 ER PT J AU Gregorkiewicz, T Andreev, BA Forcales, M Izeddin, I Jantsch, W Krasil'nik, ZF Kryzhkov, DI Kuznetsov, VP Zavada, JM AF Gregorkiewicz, Tom Andreev, Boris A. Forcales, Manuel Izeddin, Ignacio Jantsch, Wolfgang Krasil'nik, Zakhary F. Kryzhkov, Denis I. Kuznetsov, Victor P. Zavada, John M. TI Er-doped electro-optical memory element for 1.5-mu m silicon photonics SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE electroluminescence (EL); Er doping; optical memories; optoelectronic devices ID LIGHT-EMISSION; RAMAN LASER; SI DIODES; NANOCRYSTALS; ELECTROLUMINESCENCE; EFFICIENCY; STORAGE AB Silicon photonics is rapidly growing and a number of Si-based active and passive components have recently been demonstrated. We demonstrate new functionality of Er-doped silicon: a memory effect in electroluminescence. This finding opens a prospect of necessary, and thus far not available, component for Si optoelectronics-a fully complimentary metal-oxide-semiconductor-compatible electro-optical converter with a memory function, operating in the technologically important 1.5-mu m band. When developed and optimized, prospect applications could include optical intra- and inter-chip connectors and volatile flash memory elements. C1 Univ Amsterdam, Van Der Waals Zeeman Inst, NL-1018 XE Amsterdam, Netherlands. Russian Acad Sci, Inst Phys Microstruct, Nizhnii Novgorod 603600, Russia. Johannes Kepler Univ, Inst Semicond Phys, A-4040 Linz, Austria. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gregorkiewicz, T (reprint author), Univ Amsterdam, Van Der Waals Zeeman Inst, Kruislaan 403, NL-1018 XE Amsterdam, Netherlands. EM t.gregorkiewicz@uva.nl; boris@ipm.sci-nnov.ru; manuel.forcales@icfo.es; izeddin@science.uva.nl; wolfgang.jantsch@jku.at; JZavada@aro.arl.army.mil RI Krasilnik, Zakhary/B-7835-2013; Izeddin, Ignacio/H-2628-2013; Andreev, Boris/B-1182-2008 OI Krasilnik, Zakhary/0000-0003-4521-9850; Izeddin, Ignacio/0000-0002-8476-3915; Andreev, Boris/0000-0002-5692-0418 NR 25 TC 5 Z9 5 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD NOV-DEC PY 2006 VL 12 IS 6 BP 1539 EP 1544 DI 10.1109/JSTQE.2006.884062 PN 2 PG 6 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 119LL UT WOS:000243013700028 ER PT J AU Djie, HS Wang, Y Ooi, BS Wang, DN Hwang, JCM Dang, GT Chang, WH AF Djie, Hery S. Wang, Yang Ooi, Boon S. Wang, Dong-Ning Hwang, James C. M. Dang, Gerard T. Chang, Wayne H. TI Defect annealing of InAs-InAlGaAs quantum-dash-in-asymmetric-well laser SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE annealing; defect; quantum dash; quantum dots (QDs) ID 1.3 MU-M; DOT LASERS; IMPROVED PERFORMANCE; GAIN; OPERATION AB We report the improvement of similar to 1.62-mu m wavelength InAs-InAlGaAs quantum-dash-in-asymmetric-well laser performance using rapid thermal annealing. After the postgrowth annealing at 700 degrees C for 2 min, the internal quantum efficiency is increased from 90% to 93%, and the linewidth of the laser spectrum and the threshold current density is significantly reduced. C1 Lehigh Univ, Ctr Opt Technol, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Djie, HS (reprint author), Lehigh Univ, Ctr Opt Technol, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM bsooi@lehigh.edu RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 NR 13 TC 23 Z9 23 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD NOV-DEC PY 2006 VL 18 IS 21-24 BP 2329 EP 2331 DI 10.1109/LPT.2006.885301 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 121QY UT WOS:000243173300046 ER PT J AU Suchan, W Sobiesk, E AF Suchan, William Sobiesk, Edward TI Strengthening the weakest link in digital protection SO IEEE SECURITY & PRIVACY LA English DT Article C1 US Mil Acad, Dept Elect Engn & Comp Sci, IT Core Program, New York, NY USA. RP Suchan, W (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, IT Core Program, New York, NY USA. EM william.suchon@usma.edu; edward.sobiesk@usma.edu NR 6 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD NOV-DEC PY 2006 VL 4 IS 6 BP 78 EP 80 DI 10.1109/MSP.2006.166 PG 3 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 112SU UT WOS:000242548200014 ER PT J AU Kim, W Iskander, MF Palmer, WD AF Kim, Wayne Iskander, Magdy F. Devereux Palmer, W. TI An integrated phased array antenna design using ferroelectric materials and the continuous transverse stub technology SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE continuous transverse stub (CTS) antenna; coplanar waveguide; ferroelectric; low cost; multiband antenna array; phase shifter ID FILM AB In this paper, a new integrated phased array antenna system employing the ferroelectric materials technology for electronic beam steering capabilities is described. The design integrates a ferroelectric coplanar waveguide phase shifter with the continuous transverse stub (CTS) array. The phase shifter employs a multi-dielectric substrate and includes a thin layer of silicon dioxide between the signal conductors and the ferroelectric material to reduce the insertion losses and produce good impedance matching. The coplanar waveguide-based multi-dielectric layer design demonstrated an effective ferroelectric biasing architecture and exhibited an increase in figure of merit by up to 8 degrees/dB from that of the direct metallization approach. An integrated two elements phased array antenna is developed and demonstrates linearly polarized radiation with +/-20 degrees of beam scanning between the unbiased and biased states of the ferroelectric phase shifter. C1 Univ Hawaii Manoa, Coll Engn, Hawaii Ctr Adv Commun, Honolulu, HI 96822 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Kim, W (reprint author), Univ Hawaii Manoa, Coll Engn, Hawaii Ctr Adv Commun, Honolulu, HI 96822 USA. EM iskander@spectra.eng.hawaii.edu RI Palmer, William/E-2296-2012 NR 9 TC 15 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD NOV PY 2006 VL 54 IS 11 BP 3095 EP 3105 DI 10.1109/TAP.2006.883994 PN 1 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 104NT UT WOS:000241965800007 ER PT J AU Scharstein, RW Waller, ML Shumpert, TH AF Scharstein, Robert W. Waller, Marsellas L. Shumpert, Thomas H. TI Near-field and plane-wave electromagnetic coupling into a slotted circular cylinder: Hard or TE polarization SO IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY LA English DT Article DE aperture coupling; cavities; cylindrical scatterers; integral equations ID CAVITY-BACKED APERTURES; PENETRATION AB An analytically tractable model is proposed in this initial study of the electromagnetic phenomena that control our ability to synthesize, by using a near-field source, the effect of plane-wave coupling through an aperture into the interior of a vehicle under test. An integral equation for the tangential electric field in the slot aperture of a perfectly conducting, infinitesimally thin-walled circular cylinder is solved using a basis set of Chebyshev polynomials that are properly weighted according to the static edge condition. The resulting matrix elements from a Galerkin procedure are computed to high precision upon extracting the logarithmic singularity of the kernel of the integral operator. Exact expressions for the matrix elements, in the form of rapidly convergent series of elementary terms, are constructed by isolating another logarithmic function of the aperture width. A minimization of the mean-square error between the true plane-wave response and that due to a near-field line-source establishes the optimal complex source strength of the near-field source. C1 Univ Alabama, Dept Elect Engn, Tuscaloosa, AL 35487 USA. USA, Redstone Tech Test Ctr, Electromagnet Environm Effects Test Branch, Redstone Arsenal, AL 35898 USA. RP Scharstein, RW (reprint author), Univ Alabama, Dept Elect Engn, Tuscaloosa, AL 35487 USA. EM rscharst@bama.ua.edu; marsellas.waller@us.army.mil; thomas.shumpert@us.army.mil NR 20 TC 11 Z9 11 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9375 J9 IEEE T ELECTROMAGN C JI IEEE Trans. Electromagn. Compat. PD NOV PY 2006 VL 48 IS 4 BP 714 EP 724 DI 10.1109/TEMC.2006.882839 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 113NX UT WOS:000242605700016 ER PT J AU Cavalieri, DJ Markus, T Mastanik, JA Sturm, M Lobl, E AF Cavalieri, Donald J. Markus, Thorsten Mastanik, James A. Sturm, Matthew Lobl, Elena TI March 2003 EOS Aqua AMSR-E Arctic Sea ice field campaign SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Advanced Microwave Scanning Radiometer for the Earth Observing Mission (AMSR-E); Arctic; sea ice; validation AB An overview of the March 2003 coordinated sea ice field campaign in the Alaskan Arctic is presented with reference to the papers in this special section. This campaign is part of the program to validate the Aqua Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E) sea ice products. Standard AMSR-E sea ice products include sea ice concentration, sea ice temperature, and snow depth on sea ice. The validation program consists of three elements, namely: 1) satellite data comparisons; 2) coordinated satellite/aircraft/surface measurements; and 3) modeling and sensitivity analyses. Landsat-7 and RADARSAT observations were used in comparative studies with the retrieved AMSR-E sea ice concentrations. The aircraft sensors provided high-resolution microwave imagery of the surface, atmospheric profiles of temperature and humidity, and digital records of sea ice conditions. When combined with in situ measurements, aircraft data were used to validate the AMSR-E sea ice temperature and snow-depth products. The modeling studies helped interpret the field-data comparisons, provided insight on the limitations of the AMSR-E sea ice algorithms, and suggested potential improvements to the AMSR-E retrieval algorithms. C1 NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. Univ Colorado, Dept Aerosp Engn Sci, Boulder, CO 80309 USA. USA, Cold Reg Res & Engn Lab Alaska, Ft Wainwright, AK 99703 USA. Univ Alabama, Ctr Earth Syst Sci, Huntsville, AL 35899 USA. RP Cavalieri, DJ (reprint author), NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. EM donald.j.cavalieri@nasa.gov RI Markus, Thorsten/D-5365-2012 NR 13 TC 11 Z9 11 U1 2 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3003 EP 3008 DI 10.1109/TGRS.2006.883133 PN 1 PG 6 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400002 ER PT J AU Sturm, M Maslanik, JA Perovich, DK Stroeve, JC Richter-Menge, J Markus, T Holmgren, J Heinrichs, JF Tape, K AF Sturm, Matthew Maslanik, James A. Perovich, Donald K. Stroeve, Julienne C. Richter-Menge, Jackie Markus, Thorsten Holmgren, Jon Heinrichs, John F. Tape, Ken TI Snow depth and ice thickness measurements from the Beaufort and Chukchi seas collected during the AMSR-Ice03 campaign SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE cryosphere; field validation; sea ice; snow ID SPATIAL VARIABILITY; ALASKA; COVER; CLIMATE; BARROW; AREA AB In March 2003, a field validation campaign was conducted on the sea ice near Barrow, AK. The goal of this campaign was to produce an extensive dataset of sea ice thickness and snow properties (depth and stratigraphy) against which remote sensing products collected by aircraft and satellite could be compared. Chief among these were products from the Polarimetric Scanning Radiometer (PSR) flown aboard a NASA P-3B aircraft and the Aqua Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E). The data were collected in four field areas: three on the coastal sea ice near Barrow, AK, and the fourth out on the open ice pack 175 km northeast of Barrow. The snow depth ranged from 9.4-20.8 cm in coastal areas (n = 9881 for three areas) with the thinnest snow on ice that had formed late in the winter. Out in the main pack ice, the snow was 20.6 cm deep (n = 1906). The ice in all four areas ranged from 138-219 cm thick (n = 1952), with the lower value again where the ice had formed late in the winter. Snow layer and grain characteristics observed in 118 snow pits indicated that 44% of observed snow layers were depth hoar; 46% were wind slab. Snow and ice measurements were keyed to photomosaics produced from low-altitude vertical aerial photographs. Using these, and a distinctive three-way relationship between ice roughness, snow surface characteristics, and snow depth, strip maps of snow depth, each about 2 km wide, were produced bracketing the traverse lines. These maps contain an unprecedented level of snow depth detail against which to compare remote sensing products. The maps are used in other papers in this special issue to examine the retrieval of snow properties from the PSR and AMSR-E sensors. C1 USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. Univ Colorado, Colorado Ctr Astrodynam Res, Denver, CO 80262 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Univ Colorado, Cooperat Inst Res Environm Sci, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. NASA, Goddard Space Flight Ctr, Lab Hydrospher Proc, Greenbelt, MD 20771 USA. Ft Hays State Univ, Dept Geosci, Hays, KS 67601 USA. Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. RP Sturm, M (reprint author), USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. EM msturm@crrel.usace.army.mil; stroeve@kryos.colorado.edu; Thorsten.Markus@nasa.gov; jheinric@fhsu.edu RI Markus, Thorsten/D-5365-2012 NR 33 TC 30 Z9 34 U1 1 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3009 EP 3020 DI 10.1109/TGRS.2006.878236 PN 1 PG 12 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400003 ER PT J AU Maslanik, JA Sturm, M Rivas, MB Gasiewski, AJ Heinrichs, JE Herzfeld, UC Holmgren, J Klein, M Markus, T Perovich, DK Sonntag, JG Stroeve, JC Tape, K AF Maslanik, James A. Sturm, Matthew Rivas, Maria Belmonte Gasiewski, Albin J. Heinrichs, John E. Herzfeld, Ute C. Holmgren, Jon Klein, Marian Markus, Thorsten Perovich, Donald K. Sonntag, John G. Stroeve, Julienne C. Tape, Ken TI Spatial variability of barrow-area shore-fast sea ice and its relationships to passive microwave emissivity SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE passive microwave; roughness; sea ice; shore-fast ice; snow depth ID SHEET; LAKES AB Aircraft-acquired passive microwave data, laser radar height observations, RADARSAT synthetic aperture radar imagery, and in situ measurements obtained during the AMSR-Ice03 experiment are used to investigate relationships between microwave emission and ice characteristics over several space scales. The data fusion allows delineation of the shore-fast ice and pack ice in the Barrow area, AK, into several ice classes. Results show good agreement between observed and Polarimetric Scanning Radiometer (PSR)-derived snow depths over relatively smooth ice, with larger differences over ridged and rubbled ice. The PSR results are consistent with the effects on snow depth of the spatial distribution and nature of ice roughness, ridging, and other factors such as ice age. Apparent relationships exist between ice roughness and the degree of depolarization of emission at 10, 19, and 37 GHz. This depolarization would yield overestimates of total ice concentration using polarization-based algorithms, with indications of this seen when the NT-2 algorithm is applied to the PSR data. Other characteristics of the microwave data, such as effects of grounding of sea ice and large contrast between sea ice and adjacent land, are also apparent in the PSR data. Overall, the results further demonstrate the importance of macroscale ice roughness conditions such as ridging and rubbling on snow depth and microwave emissivity. C1 Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA. USA, Cold Reg Res & Engn Lab, Fairbanks, AK 99775 USA. Univ Colorado, Dept Elect & Comp Engn, Boulder, CO 80309 USA. Ft Hays State Univ, Hays, KS 67601 USA. Univ Colorado, NOAA, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. NOAA, Environm Technol Lab, Boulder, CO 80305 USA. NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. NASA, Goddard Space Flight Ctr, Wallops Flight Facil, Greenbelt, MD 20771 USA. Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. RP Maslanik, JA (reprint author), Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA. EM james.maslanik@colorado.edu RI Markus, Thorsten/D-5365-2012; Belmonte Rivas, Maria/C-9383-2015 OI Belmonte Rivas, Maria/0000-0003-0528-3858 NR 26 TC 13 Z9 13 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3021 EP 3031 DI 10.1109/TGRS.2006.879557 PN 1 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400004 ER PT J AU Herzfeld, UC Maslanik, JA Sturm, M AF Herzfeld, Ute C. Maslanik, James A. Sturm, Matthew TI Geostatistical characterization of snow-depth structures on sea ice near Point Barrow, Alaska - A contribution to the AMSR-Ice03 field validation campaign SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE classification; morphogenesis; remote sensing; roughness; sea ice; spatial data analysis ID FLOOR CLASSIFICATION; SPATIAL VARIABILITY; SURFACE; ROUGHNESS; PATTERNS; BEAUFORT; CHUKCHI; CLIMATE; WINTER; COVER AB The objective of this paper is to characterize spatial properties of snow-depth structures and their role as indicators of sea-ice properties and sea-ice-morphogenetic processes, and to provide quantitative measures of sea-ice properties that may be utilized in analyses of passive-microwave data. Snow-depth data collected near Point Barrow, Alaska, as part of the AMSR-Ice03 Field Validation Campaign for Advanced Microwave Scanning Radiometer (AMSR)-E-Sea-Ice Products from the NASA Earth Observing System Aqua satellite, are analyzed and compared to P-3 Polarimetric Scanning Radiometer (PSR) data, a proxy for AMSR-E brightness temperatures. The approach taken in the analysis is geostatistical characterization. Vario functions of first and second order are calculated for the snow-depth profiles, then geostatistical classification parameters are extracted and combined into feature vectors, on which the characterization is based. The complexity of sea ice requires a generalization of the method by introduction of the hyperparameter concept. Results include a quantitative characterization of sea-ice provinces from field transects in the Beaufort Sea, Chukchi Sea, and Elson Lagoon, which represent a good subset of Arctic sea-ice types, an internal segmentation of the longer profiles, and a derivation of surface-roughness length and of sea-ice-type complexity. PSR data reflect complexity of spatial snow-depth structures as captured in multidimensional feature vectors and, less directly, snow-depth and surface-roughness length. These results indicate that passive-microwave data in general may be affected by spatial snow depth and surface roughness, with a dependence on scale And quantified by geostatistical classification. C1 Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. Univ Colorado, Colorado Ctr Astrodynam Res, Denver, CO 80262 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Herzfeld, UC (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. EM herzfeld@tryfan.colorado.edu NR 44 TC 13 Z9 13 U1 2 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3038 EP 3056 DI 10.1109/TGRS.2006.883349 PN 1 PG 19 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400006 ER PT J AU Markus, T Cavalieri, DJ Gasiewski, AJ Klein, M Maslanik, JA Powell, DC Stankov, BB Stroeve, JC Sturm, M AF Markus, Thorsten Cavalieri, Donald J. Gasiewski, Albin J. Klein, Marian Maslanik, James A. Powell, Dylan C. Stankov, B. Boba Stroeve, Julienne C. Sturm, Matthew TI Microwave signatures of snow on sea ice: Observations SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Advanced Microwave Scanning Radiometer (AMSR); passive microwave; sea ice; snow on sea ice; validation ID AMSR-E; ALGORITHM AB Part of the Earth Observing Sysytem Aqua Advanced Microwave Scanning Radiometer (AMSR-E) Arctic sea ice validation campaign in March 2003 was dedicated to the validation of snow depth on sea ice and ice temperature products. The difficulty with validating these two variables is that neither can currently be measured other than in situ. For this reason, two aircraft flights on March 13 and 19, 2003, were dedicated to these products, and flight lines were coordinated with in situ measurements of snow and sea ice physical properties. One flight was in the vicinity of Barrow, AK, covering Elson Lagoon and the adjacent Chukchi and Beaufort Seas. The other flight was farther north in the Beaufort Sea (about 73 degrees N, 147.5 degrees W) and was coordinated with a Navy ice camp. The results confirm the AMSR-E snow depth algorithm and its coefficients for first-year ice when it is relatively smooth. For rough first-year ice and for multiyear ice, there is still a relationship between the spectral gradient ratio of 19 and 37 GHz, but a different set of algorithm coefficients is necessary. Comparisons using other AMSR-E channels did not provide a clear signature of sea ice characteristics and, hence, could not provide guidance for the choice of algorithm coefficients. The limited comparison of in situ snow-ice interface and surface temperatures with 6-GHz brightness temperatures, which are used for the retrieval of ice temperature, shows that the 6-GHz temperature is correlated with the snow-ice interface temperature to only a limited extent. For strong temperature gradients within the snow layer, it is clear that the 6-GHz temperature is a weighted average of the entire snow layer. C1 NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. NOAA, Environm Technol Lab, Boulder, CO 80305 USA. Univ Colorado, Ctr Astrodynam Res, Boulder, CO 80309 USA. Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 20715 USA. Univ Maryland Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 20715 USA. NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. Univ Colorado, Cooperat Inst Res Environm Sci, Natl Show & Ice Data Ctr, Boulder, CO 80309 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Markus, T (reprint author), NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. EM Thorsten.Markus@nasa.gov RI Markus, Thorsten/D-5365-2012 NR 13 TC 33 Z9 33 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3081 EP 3090 DI 10.1109/TGRS.2006.883134 PN 1 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400009 ER PT J AU Powell, DC Markus, T Cavalieri, DJ Gasiewski, AJ Klein, M Maslanik, JA Stroeve, JC Sturm, M AF Powell, Dylan C. Markus, Thorsten Cavalieri, Donald J. Gasiewski, Albin J. Klein, Marian Maslanik, James A. Stroeve, Julienne C. Sturm, Mathew TI Microwave signatures of snow on sea ice: Modeling SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Advanced Microwave Scanning Radiometer (AMSR); microwave; modeling; polar regions; remote sensing; sea ice; snow ID LAYERED SNOWPACKS; DEPTH ALGORITHM; EMISSION MODEL; SENSITIVITY; COVER AB Accurate knowledge of snow-depth distribution over sea ice is critical for polar climate studies. Current snow-depth-over-sea-ice retrieval algorithms do not sufficiently account for variations in snow and ice physical properties that can affect the accuracy of retrievals. For this reason, airborne microwave observations were coordinated with ground-based measurements of snow depth and snow properties in the vicinity of Barrow, AK, in March 2003. In this paper, the effects of snowpack properties and ice conditions on microwave signatures are examined using detailed surface-based measurements and airborne observations in conjunction with a thermal microwave-emission model. A comparison of the Microwave Emission Model of Layered Snowpacks (MEMLS) simulations with detailed snowpack and ice data from stakes along the Elson Lagoon and the Beaufort Sea and radiometer data taken from low-level flights using a Polarimetric Scanning Radiometer (PSR-A) shows that MEMLS can be used to simulate snow on sea ice and is a useful tool for understanding the limitations of the snow-depth algorithm. Analysis of radiance data taken over the Elson Lagoon and the Beaufort Sea using MEMLS suggests that the radiometric differences between the two locations are due to the differences in sea-ice emissivity. Furthermore, measured brightness temperatures suggest that the current snow-depth retrieval algorithm is sufficient for areas of smooth first-year sea ice, whereas new algorithm coefficients are needed for rough first-year sea ice. Snowpack grain size and density remain an unresolved issue for snow-depth retrievals using passive-microwave radiances. C1 Univ Maryland Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 20715 USA. Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 20715 USA. NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. Univ Colorado, Dept Elect & Comp Engn, Boulder, CO 80309 USA. NOAA, Environm Technol Lab, Boulder, CO 80305 USA. Univ Colorado, Ctr Astrodynam Res, Boulder, CO 80309 USA. Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. Cold Reg Res & Engn Lab, Fairbanks, AK 99703 USA. RP Powell, DC (reprint author), Earth Observing Syst, Greenbelt, MD 20770 USA. EM Thorsten.Markus@nasa.gov RI Markus, Thorsten/D-5365-2012 NR 30 TC 18 Z9 20 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3091 EP 3102 DI 10.1109/TGRS.2006.882139 PN 1 PG 12 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400010 ER PT J AU Stroeve, JC Markus, T Maslanik, JA Cavalieri, DJ Gasiewski, AJ Heinrichs, JE Holmgren, J Perovich, DK Sturm, M AF Stroeve, Julienne C. Markus, Thorsten Maslanik, James A. Cavalieri, Donald J. Gasiewski, Albin J. Heinrichs, John E. Holmgren, Jon Perovich, Donald K. Sturm, Matthew TI Impact of surface roughness on AMSR-E sea ice products SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE passive microwave; remote sensing; sea ice ID PARAMETERS; GREENLAND; SNOW AB This paper examines the sensitivity of Advanced Microwave Scanning Radiometer (AMSR-E) brightness temperatures (Tbs) to surface roughness by a using radiative transfer model to simulate AMSR-E Tbs as a function of incidence angle at which the surface is viewed. The simulated Tbs are then used to examine the influence that surface roughness has on two operational sea ice algorithms, namely: 1) the National Aeronautics and Space Administration Team (NT) algorithm and 2) the enhanced NT algorithm, as well as the impact of roughness on the AMSR-E snow depth algorithm. Surface snow and ice data collected during the AMSR-Ice03 field campaign held in March 2003 near Barrow, AK, were used to force the radiative transfer model, and resultant modeled Tbs are compared with airborne passive microwave observations from the Polarimetric Scanning Radiometer. Results indicate that passive microwave Tbs are very sensitive even to small variations in incidence angle, which can cause either an over-or underestimation of the true amount of sea ice in the pixel area viewed. For example, this paper showed that if the sea ice areas modeled in this paper were assumed to be completely smooth, sea ice concentrations were underestimated by nearly 14% using the NT sea ice algorithm and by 7% using the enhanced NT algorithm. A comparison of polarization ratios (PRs) at 10.7, 18.7, and 37 GHz indicates that each channel responds to different degrees of surface roughness and suggests that the PR at 10.7 GHz can be useful for identifying locations of heavily ridged or rubbled ice. Using the PR at 10.7 GHz to derive an "effective" viewing angle, which is used as a proxy for surface roughness, resulted in more accurate retrievals of sea ice concentration for both algorithms. The AMSR-E snow depth algorithm was found to be extremely sensitive to instrument calibration and sensor viewing angle, and it is concluded that more work is needed to investigate the sensitivity of the gradient ratio at 37 and 18.7 GHz to these factors to improve snow depth retrievals from spaceborne passive microwave sensors. C1 Univ Colorado, NOAA, Cooperat Inst Res Environm Sci, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA. Univ Colorado, Dept Elect & Comp Engn, Boulder, CO 80309 USA. Ft Hays State Univ, Dept Geosci, Hays, KS 67601 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Stroeve, JC (reprint author), Univ Colorado, NOAA, Cooperat Inst Res Environm Sci, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. EM stroeve@kodiak.colorado.edu RI Stroeve, Julienne/D-1525-2010; Markus, Thorsten/D-5365-2012 NR 21 TC 27 Z9 27 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2006 VL 44 IS 11 BP 3103 EP 3117 DI 10.1109/TGRS.2006.880619 PN 1 PG 15 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 104CK UT WOS:000241933400011 ER PT J AU Richardson, PC Xiang, WG Mohammad, S AF Richardson, Paul C. Xiang, Weidgong Mohammad, Syed TI Performance analysis of a real-time control network test bed in a Linux-based system with sporadic message arrivals SO IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS LA English DT Article DE controller area network (CAN); Linux system; real-time networks; testbed ID AREA NETWORK; IMPLEMENTATION; PROTOCOL; DESIGN AB This paper describes the results from a real-time network test bed for a Linux-based control system with event-driven message traffic. Interest has grown in the use of Linux as a cost-effective alternative to expensive proprietary real-time operating systems. However, kernel tasks in Linux can cause random delays in message transmissions. Event-driven traffic can result in unpredictable message inter-arrival rates. Nondeterministic delays in message transmissions and sporadic message arrival times complicate the design of the network as they require the use of an estimation technique to analyze feasibility. Random temporal behavior can lead to network overloads, where it becomes unavoidable that some messages will be late. We discuss the design and feasibility analysis for the network and evaluate the network's performance in the presence of random kernel delay and sporadic message arrivals. Three message scheduling approaches are evaluated using different Linux configurations at different levels of network loading. C1 Univ Michigan, Dearborn, MI 48128 USA. USA, TARDEC, Warren, MI 48397 USA. RP Richardson, PC (reprint author), Univ Michigan, Dearborn, MI 48128 USA. NR 26 TC 4 Z9 5 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1551-3203 EI 1941-0050 J9 IEEE T IND INFORM JI IEEE Trans. Ind. Inform. PD NOV PY 2006 VL 2 IS 4 BP 231 EP 241 DI 10.1109/TII.2006.885925 PG 11 WC Automation & Control Systems; Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Automation & Control Systems; Computer Science; Engineering GA 114UV UT WOS:000242692000003 ER PT J AU Dong, M Tong, L Sadler, BM AF Dong, Min Tong, Lang Sadler, Brian M. TI Impact of data retrieval pattern on homogeneous signal field reconstruction in dense sensor networks SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE data retrieval; estimation; random field; sampling; sensor network; signal reconstruction ID CONTINUOUS-TIME PROCESSES; INTERPOLATION AB We analyze the impact of data retrieval pattern on the reconstruction performance of a one-dimensional homogeneous random field measured by a large-scale sensor network. From a networking perspective, we connect data retrieval protocols and different sampling schemes. Specifically, we show that the data retrieval pattern affects the efficiency of reconstruction; as the number of received packets M increases, the deterministic retrieval pattern that schedules sensors to transmit from equally spaced locations results in a faster decay of distortion than the random pattern does. In particular, we show that the ratio of the excess reconstruction distortion under the random retrieval pattern to that under the deterministic one grows as log M + O (log log M). Comparing the reconstruction performance directly, we further show that, in the high measurement signal-to-noise ratio (SNR) regime, the benefit from carefully scheduling sensor transmissions from specific locations instead of collecting in a random fashion is substantial. In the low SNR regime, however, using the random pattern results in little reconstruction performance loss. Finally, as M -> infinity, we show the strong convergence property of reconstruction distortion under the random pattern. C1 Qualcomm Inc, Corp R&D, San Diego, CA 92121 USA. Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Dong, M (reprint author), Qualcomm Inc, Corp R&D, San Diego, CA 92121 USA. EM mdong@qualcomm.com; ltong@ece.cornell.edu; bsadler@arl.army.mil NR 21 TC 21 Z9 24 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD NOV PY 2006 VL 54 IS 11 BP 4352 EP 4364 DI 10.1109/TSP.2006.881233 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 098QK UT WOS:000241537700025 ER PT J AU Bidus, MA Krivak, TC Howard, R Rose, GS Cosin, J Dainty, L Elkas, JC AF Bidus, M. A. Krivak, T. C. Howard, R. Rose, G. S. Cosin, J. Dainty, L. Elkas, J. C. TI Hematologic changes after splenectomy for cytoreduction: implications for predicting infection and effects on chemotherapy SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE splenectomy; cytoreduction; chemotherapy; infection; ovarian cancer ID EPITHELIAL OVARIAN-CANCER; POSTSPLENECTOMY; RISK AB Postsplenectomy leukocytosis and thrombocytosis are common findings in trauma patients. The intent of this study is to describe postsplenectomy hematologic changes in gynecological oncology surgery and subsequent chemotherapy. We performed a retrospective record review of gynecological oncology patients at our institutions. Postsurgical hematologic changes, infectious morbidity, and pre- and post-chemotherapy hematologic changes were noted. Data were analyzed using repeated measures analysis of variance. We identified 27 patients who underwent cytoreductive surgery with splenectomy. Thirteen patients with splenectomy had postoperative chemotherapy data available, and we matched these patients with 13 control patients who underwent cytoreduction surgery without splenectomy and postoperative chemotherapy. Nine of the 27 splenectomy patients had documented infectious morbidity. There was a significant difference in postoperative platelet counts between the infected and the noninfected splenectomy patients (P=0.037), and a significant difference between splenectomy and control patients for white blood cell (WBC) counts (P=0.007). Patients with splenectomy had higher precycle WBC, absolute neutrophil count (ANC), platelet counts, and higher postcycle nadir levels in all cycles compared to control patients. There was a significant overall difference between splenectomy patients and controls with regard to WBC (P=0.001), ANC (P=0.005), and platelet counts (P=0.016) during chemotherapy cycles. Median postchemotherapy nadir WBC was 4.4 (range: 3.4-4.8) for the splenectomy group versus 2.8 (range: 2.5-3.0) for the control group. Median postchemotherapy nadir ANC was 1800 (range: 1320-2450) for the splenectomy group and 1001 (range: 864-1064) for the control group. Median postchemotherapy nadir platelet count was 222 (range: 181-277) for the splenectomy patients and 169 (range 164-215) for the control patients. In conclusion, the patients who undergo splenectomy as part of cytoreductive surgeries have a statistically significant leukocytosis and insignificant thrombocytosis relative to the control patients. Leukocytosis alone is not an accurate indicator of infection. Splenectomy is not associated with an increased risk of chemotherapy-related neutropenia and thrombocytopenia. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20309 USA. Univ Pittsburgh, Magee Womens Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, Pittsburgh, PA 15213 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Biometr Sect, Washington, DC 20307 USA. Washington Hosp Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20010 USA. RP Bidus, MA (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20309 USA. EM Michael.Bidus@na.amedd.army.mil NR 11 TC 6 Z9 6 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD NOV-DEC PY 2006 VL 16 IS 6 BP 1957 EP 1962 DI 10.1111/j.1525-1438.2006.00725.x PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 114JI UT WOS:000242662100001 PM 17177832 ER PT J AU Dunn, JS Gruber, D Broberg, J Fischer, JR Thornton, JA AF Dunn, James S., Jr. Gruber, Daniel Broberg, Jeff Fischer, John R. Thornton, Jennifer A. TI Urogynecology practice patterns among Air Force obstetricians and gynecologists: survey results SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article DE urogynecology training; obstetrics and gynecology training; core curriculum; military physicians ID PELVIC FLOOR DISORDERS; URINARY-INCONTINENCE; FEMALE SOLDIERS AB The objective of this study was to describe the practice patterns of physicians in the United States Air Force regarding the evaluation and treatment of female pelvic floor disorders including urinary incontinence and pelvic organ prolapse. A self-administered survey of 22 questions was electronically mailed to all active duty Air Force obstetricians & gynecologists. Fifty-one surveys were returned for a 51% response rate. Eighty-four percent of physicians treat urinary incontinence. A smaller percentage perform advanced reconstructive techniques, using biomaterials (35%), colpocleisis (39%), overlapping sphincter repairs (45%), and abdominal sacrocolpopexy (27%). When questioned about urogynecology training during residency, most respondents report inadequate training in advanced pelvic surgery techniques. In conclusion, the majority of Air Force obstetricians and gynecologists feel comfortable treating uncomplicated urinary incontinence but do not routinely perform advanced urogynecology surgeries. There is a continued need to train physicians in female pelvic medicine to treat a unique patient population. C1 David Grant USAF Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Dunn, JS (reprint author), David Grant USAF Med Ctr, Clin Invest Facil, 101 Bodin Circle, Travis AFB, CA 94535 USA. EM James.dunn@travis.af.mil NR 14 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER LONDON LTD PI GODALMING PA SWEETAPPLE HOUSE CATTESHALL ROAD, GODALMING GU7 3DJ, SURREY, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD NOV PY 2006 VL 17 IS 6 BP 598 EP 603 DI 10.1007/s00192-006-0073-2 PG 6 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 094SM UT WOS:000241259300011 PM 16820999 ER PT J AU Bautista, CT Sateren, WB Sanchez, JL Rathore, Z Singer, DE Birx, DL Scott, PT AF Bautista, Christian T. Sateren, Warren B. Sanchez, Jose L. Rathore, Zahid Singer, Darrell E. Birx, Deborah L. Scott, Paul T. TI HIV incidence trends among white and African-American active duty United States army personnel (1986-2003) SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE African American; army personnel; HIV; incidence; joinpoint; military personnel; trends; white; United States ID RISK BEHAVIORS; MEN; SEROCONVERSION; SURVEILLANCE; INFECTION AB Objective: To analyze HIV incidence rate (IR) trends among white and African-American active duty US Army personnel between 1986 and 2003. Methods: Joinpoint regression was applied to identify time periods when significant changes in HIV IRs occurred, along with the corresponding annual percentage changes (APCs). Results: African-Americans had a higher IR than white personnel (0.34/1000 vs. 0.07/1000; P < 0.001). Among white personnel, 2 significant time periods of changing HIV IRs were found: between 1986 and 1989 (APC = - 31.1; P = 0.006) and between 1989 and 2003 (APC = -5.7; P = 0.003). Among Affican-Americans, a significant decline in HIV IRs was observed only between 1986 and 1991 (APC = - 19.4; P < 0.001). This study revealed that the HIV IRs seem to have increased in 2 Affican-American groups: unmarried personnel and health care professionals. Conclusion: This cohort study (1,280 incident HIV infections among 1.5 million persons with 8.4 million person-years of follow-up) provides invaluable information on HIV trends in the United States Army. Despite an overall decline in HIV IRs, certain subpopulation among African-American personnel were observed to have increasing HIV IRs. Future research is needed to identify the current behavioral risk factors associated with HIV infection among US Army personnel. C1 Walter Reed Army Inst Res, US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Div Retrovirol, Rockville, MD 20850 USA. Henry M Jackson Fdn Adv Mil Med Inc, Rockville, MD USA. Booz Allen & Hamilton Inc, Rockville, MD USA. RP Bautista, CT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011 NR 12 TC 8 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD NOV 1 PY 2006 VL 43 IS 3 BP 351 EP 355 DI 10.1097/01.qai.0000243051.35204.d0 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 099KB UT WOS:000241592000014 PM 16980911 ER PT J AU Ellis, TS Park, KT Ulrich, MD Hulbert, SL Rowe, JE AF Ellis, Trinity S. Park, Kenneth T. Ulrich, Marc D. Hulbert, Steven L. Rowe, Jack E. TI Interaction of metallophthalocyanines (MPc, M=Co, Ni) on Au(001): Ultraviolet photoemission spectroscopy and low energy electron diffraction study SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SCANNING-TUNNELING-MICROSCOPY; 100 CRYSTAL FACES; COPPER-PHTHALOCYANINE; PHOTOELECTRON-SPECTROSCOPY; THIN-FILMS; SURFACE RECONSTRUCTIONS; VALENCE-BAND; GOLD; MOLECULES; AU(111) AB Thin films of metallophthalocyanine (MPc,M=Co,Ni) evaporated onto a "5x20" reconstructed Au(001) substrate at room temperature have been investigated by employing low energy electron diffraction (LEED) and ultraviolet photoelectron spectroscopy (UPS). The LEED images from NiPc thin films show that the overlayers are highly ordered with a square unit cell of 12.8x12.8 A(2) aligned along the < 110 > and < 1 (1) over bar0 > axes of the Au(001) substrate. For CoPc, the LEED pattern reveals the superposition of multiple rotationally equivalent domains of a 12.9x12.9 A(2) square lattice which are rotated by 16 degrees with respect to each other. The contrast between NiPc and CoPc on Au(001) is further demonstrated in the interfacial electronic structure. UPS studies of the interfacial layers of NiPc deposited on the hexagonally reconstructed gold substrate indicate that NiPc physisorbs on the gold surface as evidenced by a uniform molecular orbital (MO) shift. The CoPc MO's, on the other hand, indicates a charge transfer at the interface, evidenced by the 13a(1g) MO interacting with the Au surface. (c) 2006 American Institute of Physics. C1 Baylor Univ, Dept Phys, Waco, TX 76798 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Brookhaven Natl Lab, Natl Synchrotron Light Source, Upton, NY 11973 USA. Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. RP Park, KT (reprint author), Baylor Univ, Dept Phys, Waco, TX 76798 USA. EM kenneth_park@baylor.edu NR 35 TC 42 Z9 43 U1 1 U2 26 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 2006 VL 100 IS 9 AR 093515 DI 10.1063/1.2364034 PG 10 WC Physics, Applied SC Physics GA 105OO UT WOS:000242041500028 ER PT J AU West, BJ Maciejewski, A Latka, M Sebzda, T Swierczynski, Z Cybulska-Okolow, S Baran, E AF West, Bruce J. Maciejewski, Artur Latka, Miroslaw Sebzda, Tadeusz Swierczynski, Zbigniew Cybulska-Okolow, Sylwia Baran, Eugeniusz TI Wavelet analysis of scaling properties of gastric electrical activity SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE electrogastrography; gastric rate variability; systemic sclerosis; fractal physiology; average wavelet coefficients; fractal time series ID PROGRESSIVE SYSTEMIC-SCLEROSIS; MYOELECTRICAL ACTIVITY; FRACTAL NATURE; HUMAN GAIT; DYNAMICS; ELECTROGASTROGRAPHY; INVOLVEMENT; RESPIRATION; WALKING AB We present a novel approach to the analysis of fluctuations in human myoelectrical gastric activity measured noninvasively from the surface of the abdomen. The time intervals between successive maxima of the wavelet transformed quasi-periodic electrogastrographic waveform define the gastric rate variability (GRV) time series. By using the method of average wavelet coefficients, the statistical fluctuations in the GRV signal in healthy individuals are determined to scale in time. Such scaling was previously found in a variety of physiological phenomena, all of which support the hypothesis that physiological dynamics utilize fractal time series. We determine the scaling index in a cohort of 17 healthy individuals to be 0.80 +/- 0.14, which compared with a set of surrogate data is found to be significant at the level P < 0.01. We also determined that the dynamical pattern, so evident in the spectrum of average wavelet coefficients of the GRV time series of healthy individuals, is significantly reduced in a cohort of systemic sclerosis patients having a scaling index 0.64 +/- 0.17. These results imply that the long-term memory in GRV time series is significantly reduced from healthy individuals to those with systemic sclerosis. Consequently, this disease degrades the complexity of the underlying gastrointestinal control system and this degradation is manifest in the loss of scaling in the GRV time series. C1 USA, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. Wroclaw Tech Univ, Inst Phys, PL-50370 Wroclaw, Poland. Wroclaw Tech Univ, Dept Pathophysiol, PL-50370 Wroclaw, Poland. Wroclaw Tech Univ, Dept Elect & Photon Metrol, PL-50370 Wroclaw, Poland. Wroclaw Tech Univ, Dept Dermatol Venerol & Allergol, PL-50370 Wroclaw, Poland. RP West, BJ (reprint author), USA, Res Off, Math & Informat Sci Directorate, POB 12211, Res Triangle Pk, NC 27709 USA. EM Bruce.J.West@us.army.mil RI Ramli, Roziana/E-7157-2010 NR 35 TC 5 Z9 6 U1 0 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV PY 2006 VL 101 IS 5 BP 1425 EP 1431 DI 10.1152/japplphysiol.01364.2004 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 107GS UT WOS:000242159300025 PM 16794018 ER PT J AU Burke, CS Stagl, KC Salas, E Pierce, L Kendall, D AF Burke, C. Shawn Stagl, Kevin C. Salas, Eduardo Pierce, Linda Kendall, Dana TI Understanding team adaptation: A conceptual analysis and model SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Review DE teams; teamwork; team adaptation; adaptability; team effectiveness ID SITUATION AWARENESS; COGNITIVE-ABILITY; PERFORMANCE; WORK; INNOVATION; PERSONALITY; BEHAVIOR; INTERDEPENDENCE; COOPERATION; MANAGEMENT AB This endeavor provides a multidisciplinary, multilevel, and multiphasic conceptualization of team adaptation with theoretical roots in the cognitive, human factors, and industrial- organizational psychology literature. Team adaptation and the emergent nature of adaptive team performance are defined from a multilevel, theoretical standpoint. An input-throughput-output model is advanced to illustrate a series of phases unfolding over time that constitute the core processes and emergent states underlying adaptive team performance and contributing to team adaptation. The cross-level mixed-determinants model highlights team adaptation in a nomological network of lawful relations. Testable propositions, practical implications, and directions for further research in this area are also advanced. C1 Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32826 USA. Univ Cent Florida, Dept Psychol, Orlando, FL 32826 USA. USA, Res Lab, Human Res & Engn Directorate, Adelphi, MD USA. RP Burke, CS (reprint author), Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM sburke@ist.ucf.edu NR 118 TC 188 Z9 196 U1 10 U2 105 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD NOV PY 2006 VL 91 IS 6 BP 1189 EP 1207 DI 10.1037/0021-9010.91.6.1189 PG 19 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 102LI UT WOS:000241812100001 PM 17100478 ER PT J AU Irish, JL Wozencraft, JM Cunningham, AG Giroud, C AF Irish, Jennifer L. Wozencraft, Jennifer M. Cunningham, A. Grant Giroud, Claudine TI Nonintrusive measurement of ocean waves: Lidar wave gauge SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID SPECTRA; SURFACE; CURVATURE; LASER; SLOPE AB In December 1999, a nonintrusive directional lidar wave gauge (LWG) was field tested at the Field Research Facility (FRF) in North Carolina. The LWG uses proven lidar technology to directly measure water surface elevation from above the water's surface. Therefore, unlike bottom-mounted gauges, the surface elevation measurement from the LWG is independent of other hydrodynamic processes. The LWG prototype consists of four rangefinders, where each collects water surface elevation time series at a rate of 10 Hz. During the field test, ground truth data were collected concurrently with the LWG data using a biaxial current and pressure meter mounted directly beneath the LWG. Additional ground truth data were available from the existing FRF wave-gauging infrastructure. This paper describes principles of LWG operation and field experiment setup, LWG environmental and technical constraints, and LWG performance in measuring spectral wave parameters. C1 US Army Corps Engineers, New York, NY USA. US Army Corps Engineers, Mobile, AL USA. Optech Inc, Toronto, ON, Canada. RP Irish, JL (reprint author), Texas A&M Univ, Dept Civil Engn, 3136 TAMU, College Stn, TX 77843 USA. EM jirish@civil.tamu.edu OI Irish, Jennifer/0000-0002-2429-5953 NR 18 TC 8 Z9 8 U1 0 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD NOV PY 2006 VL 23 IS 11 BP 1559 EP 1572 DI 10.1175/JTECH1936.1 PG 14 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA 109FP UT WOS:000242293600012 ER PT J AU Agee, KA Becker, TD Joyce, AP Rueggeberg, FA Borke, JL Waller, JL Tay, FR Pashley, DH AF Agee, Kelli A. Becker, Thomas D. Joyce, Anthony P. Rueggeberg, Frederick A. Borke, James L. Waller, Jennifer L. Tay, Franklin R. Pashley, David H. TI Net expansion of dried demineralized dentin matrix produced by monomer/alcohol saturation and solvent evaporation SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE collagen; dentin matrix; solubility parameters; dimensional changes ID DIMENSIONAL CHANGES; SOLUBILITY PARAMETER; PHASE-SEPARATION; BOND STRENGTHS; WATER; RESIN; HEMA; INTERFACE; ADHESIVES; PRIMERS AB The purpose of this work was to determine if nonaqueous methacrylate monomer/alcohol mixtures could expand dried collapsed demineralized dentin matrix. Thin disks (ca. 200 mu m) of human dentin were demineralized and placed in wells beneath contact probes of linear variable differential transformers. The probes were placed on water-saturated expanded matrices to record the shrinkage associated with drying. Monomer mixtures containing hydroxyethyl methacrylate, 2,2-bis[4-(2-hydroxy-3 methacryloyloxy)propoxyphenyl] propane, or triethyleneglycol dimethacrylate were mixed with methanol or ethanol at alcohol/monomer mass fraction % of 90/10, 70/30, 50/50, or 30/70. They were randomly applied to the dried matrices to determine the rate and magnitude of expansion; then shrinkage was recorded during evaporation of the alcohols. The results indicated that matrix expansion was positively correlated with the Hoy's solubility parameters for hydrogen bonding forces (delta(h)) of the monomer/solvent mixtures (p < 0.001). Expansions were more rapid with methanol-containing than with ethanol-containing monomer mixtures. For the test solutions, triethyleneglycol dimethacrylate-containing mixtures produced the slowest rate of matrix expansion and hydroxyethyl methacrylate-containing mixtures the most rapid expansion. When the solvents were evaporated, the matrix shrank in proportion to the solvent content and the delta(h) of the monomer-solvent mixtures. The results indicate that expansion of dried, collapsed dentin matrices requires that the delta(h) of the mixtures be larger than 17 (J/cm(3))(1/2). The greater the delta(h) of the monomer solutions, the greater the rate and extent of expansion. (c) 2006 Wiley Periodicals, Inc. C1 Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. USA, DENTAC, Ft Gordon, GA 30905 USA. Med Coll Georgia, Sch Dent, Dept Oral Rehabil, Div Sci Mat, Augusta, GA 30912 USA. RP Pashley, DH (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. EM dpashley@mcg.edu RI Rastelli, Marcio/B-8034-2011 FU NIDCR NIH HHS [R01 DE 014911] NR 29 TC 23 Z9 25 U1 0 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1549-3296 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD NOV PY 2006 VL 79A IS 2 BP 349 EP 358 DI 10.1002/jbm.a.30752 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 092YB UT WOS:000241132500015 PM 16883589 ER PT J AU Owens, BD Goss, TP AF Owens, B. D. Goss, T. P. TI The floating shoulder SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME LA English DT Article ID SCAPULAR NECK FRACTURES; NONOPERATIVE TREATMENT; IPSILATERAL FRACTURES; CONSERVATIVE TREATMENT; CLAVICULAR FRACTURE; INTERNAL-FIXATION; OPEN REDUCTION; NONUNION AB The floating shoulder is defined as ipsilateral fractures of the midshaft of the clavicle and the neck of the glenoid. This rare injury can be difficult to manage without a thorough understanding of the complex anatomy of the shoulder girdle. Surgical intervention needs to be considered for all of these injuries. While acceptable results can be expected with non-operative management of minimally-displaced fractures, displacement at one or both sites is best managed with surgical reduction and fixation. C1 Keller Army Hosp, West Point, NY 10996 USA. Univ Massachusetts, Sch Med, Worcester, MA 01655 USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 36 TC 17 Z9 33 U1 0 U2 2 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 0301-620X J9 J BONE JOINT SURG BR JI J. Bone Joint Surg.-Br. Vol. PD NOV PY 2006 VL 88B IS 11 BP 1419 EP 1424 DI 10.1302/0301-620X.88B11.17997 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 109JD UT WOS:000242303100002 PM 17075083 ER PT J AU Eshleman, JL Dean, RG Hathaway, KK AF Eshleman, Jodi L. Dean, Robert G. Hathaway, Kent K. TI Wave friction factors from energy flux comparisons outside of the surf zone SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE wave shoaling; energy dissipation; nearshore; energy flux ID BOTTOM FRICTION AB Pressure, sonar profiling, and current measurements were recorded at 5.5-, 8-, and 13-m water depths in the outer surf zone and inner continental shelf region off the coast of Duck, North Carolina. This unique data set was analyzed to investigate wave evolution by comparing estimates from linear wave theory with field measurements. Energy flux calculations combining shoaling and refraction theory showed smaller measured than predicted energy flux values at the two inshore locations (sometimes by more than one third), emphasizing the importance of considering energy loss in engineering design and planning calculations. A wave friction factor for each record was determined by accounting for frictional energy loss in the energy flux calculation, using velocity time series measured 0.20, 0.55, and 1.50 m above the sea floor. Calculated friction factors varied throughout storm events, but most fell within a range of 0 to 0.1. Wave friction factors calculated using the total measured velocity time series showed a narrower range (0 to 0.05) than those calculated from demeaned velocities (0 to 0.1). Representative wave friction factors of 0.053 (demeaned velocity) and 0.0209 (total velocity) were identified for this location using a least squares fit between energy flux decay and vertical bar u(b)vertical bar(3)Delta x over all storm events. C1 Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. Field Res Facil, Coastal & Hydraul Lab, Kitty Hawk, NC 27949 USA. RP Eshleman, JL (reprint author), Univ Florida, Dept Civil & Coastal Engn, 554 Weil Hall, Gainesville, FL 32611 USA. EM jeshleman@usgs.gov NR 12 TC 1 Z9 1 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD NOV PY 2006 VL 22 IS 6 BP 1490 EP 1498 DI 10.2112/04-0285 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 114WA UT WOS:000242695100017 ER PT J AU Kennedy, LG Everett, JW Becvar, E Defeo, D AF Kennedy, Lonnie G. Everett, Jess W. Becvar, Erica DeFeo, Donald TI Field-scale demonstration of induced biogeochemical reductive dechlorination at Dover Air Force Base, Dover, Delaware SO JOURNAL OF CONTAMINANT HYDROLOGY LA English DT Article DE biogeochemical reductive dechlorination; TCE; FeS; reduced minerals ID IRON SULFIDE; NATURAL ATTENUATION; TRANSFORMATION; KINETICS; PYRITE AB Biogeochemical reductive dechlorination (BiRD) is a new remediation approach for chlorinated aliphatic hydrocarbons (CAHs). The approach stimulates common sulfate-reducing soil bacteria, facilitating the geochemical conversion of native iron minerals into iron sulfides. Iron sulfides have the ability to chemically reduce many common CAH compounds including PCE, TCE, DCE, similar to zero valent iron (Fe-0). Results of a field test at Dover Air Force Base, Dover, Delaware, are given in this paper. BiRD was stimulated by direct injection of Epson salt (MgSO4 center dot 7H(2)O) and sodium (L) lactate (NaC3H5O3) in five injection wells. Sediment was sampled before and 8 months after injection. Significant iron sulfide minerals developed in the sandy aquifer matrix. From ground water analyses, treatment began a few weeks after injection with up to 95% reduction in PCE, TCE, and cDCE in less than I year. More complete CAH treatment is likely at a larger scale than this demonstration. (c) 2006 Elsevier B.V. All rights reserved. C1 Rowan Univ, Glassboro, NJ 08028 USA. Earth Sci Serv, Oklahoma City, OK 73116 USA. USAF, Ctr Environm Excellence, Brooks AFB, TX USA. USA, Corps Engineers, Philadelphia, PA USA. RP Everett, JW (reprint author), Rowan Univ, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA. EM lonnie_kennedy@earthscienceserv.com; everett@rowan.edu; Erica.Becvar@brooks.af.mil; Donald.M.DeFeo@usace.army.mil NR 20 TC 24 Z9 24 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7722 J9 J CONTAM HYDROL JI J. Contam. Hydrol. PD NOV PY 2006 VL 88 IS 1-2 BP 119 EP 136 DI 10.1016/j.jconhyd.2006.06.007 PG 18 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA 109OK UT WOS:000242317700007 PM 16949177 ER PT J AU Gamble, WB AF Gamble, W. Bryan TI Recent advances made in wartime medical care SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Editorial Material C1 USA, Med Corps, Landstuhl Reg Med Ctr, Washington, DC 20310 USA. RP Gamble, WB (reprint author), USA, Med Corps, Landstuhl Reg Med Ctr, Washington, DC 20310 USA. EM Bryan.Gamble2@amedd.army.mil NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD NOV PY 2006 VL 17 IS 6 BP 1033 EP 1034 DI 10.1097/01.scs.0000234988.92239.01 PG 2 WC Surgery SC Surgery GA 119WJ UT WOS:000243044700002 PM 17119400 ER PT J AU Cuda, SP Brand, TC Thibault, GP Stack, RS AF Cuda, Scott P. Brand, Timothy C. Thibault, Gregory P. Stack, Richard S. TI Case report: Endoscopic laser lithotripsy of seminal-vesicle stones SO JOURNAL OF ENDOUROLOGY LA English DT Article ID CALCULI AB A 25-year-old man presented with painful ejaculation, an ejaculate volume of 0.75, and complaints of passing "granules" in the semen. Transrectal ultrasonography showed bilateral seminal vesicle enlargement. The patient underwent transurethral resection of the ejaculatory duct. The entry point of duct was resected using pure cutting current, resulting in the passage of multiple proteinaceous-appearing stones. Approximately 10 months later, the patient reported recurrent painful ejaculation and passage of granules in his semen. At cystoscopy, the ejaculatory duct openings were intubated with a cone-tipped catheter to perform bilateral seminal vesiculograms, which showed numerous mobile filling defects and a Steinstrasse appearance at the ejaculatory ducts. A 7F semirigid ureteroscope entered the lumen without difficulty over a guidewire, and the stones were fragmented with a 270-mu m holmium laser fiber. The ejaculatory ducts were balloon dilated to 18F. To our knowledge, this is the first reported case where a ureteroscope was utilized to treat seminal-vesicle stones. The seminal vesiculogram proved to be extremely valuable in the diagnosis. C1 Tripler Army Med Ctr, Dept Urol, MCHK DSU, Honolulu, HI 96859 USA. RP Stack, RS (reprint author), Tripler Army Med Ctr, Dept Urol, MCHK DSU, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM Richard.Stack@amedd.army.mil NR 8 TC 7 Z9 13 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0892-7790 J9 J ENDOUROL JI J. Endourol. PD NOV PY 2006 VL 20 IS 11 BP 916 EP 918 DI 10.1089/end.2006.20.916 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 113ZS UT WOS:000242637100015 PM 17144863 ER PT J AU Dontsova, KM Yost, SL Simunek, J Pennington, JC Williford, CW AF Dontsova, Katerina M. Yost, Sally L. Simunek, Jiri Pennington, Judith C. Williford, Clint W. TI Dissolution and transport of TNT, RDX, and Composition B in saturated soil columns SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID ENVIRONMENTAL FATE; WATER SLURRIES; ADSORPTION; 2,4,6-TRINITROTOLUENE; EXPLOSIVES; SORPTION; TRANSFORMATION; DESORPTION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; STABILITY AB Low-order detonations and blow-in-place procedures on military training ranges can result in residual solid explosive formulations to serve as distributed point sources for ground water contamination. This study was conducted to determine if distribution coefficients from batch studies and transport parameters of pure compounds in solution adequately describe explosive transport where compounds are present as solid particles in formulations. Saturated column transport experiments were conducted with 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and the explosive formulation, Composition B (Comp B) (59.5 +/- 2.0% RDX, 39.5 +/- 2.3% TNT, and 1% wax) in solid and dissolved forms. The two soils used were Plymouth loamy sand (mesic, coated Typic Quartzipsamments) from Camp Edwards, MA and Adler silt loam (coarse-silty, mixed, superactive, thermic Fluvaquentic Eutrudepts) from Vicksburg, MS. Interrupted flow experiments were used to determine if explosives were at equilibrium distribution between soil and solution phases. The HYDRUS-1D code was used to determine fate and transport parameters. Results indicated that sorption of high explosives was rate limited. The behavior of dissolved Comp B was similar to the behavior of pure TNT and RDX. Behavior of solid Comp B was controlled by dissolution that depended on physical properties of the Comp B sample. Adsorption coefficients determined by HYDRUS-1D were different from those determined in batch tests for the same soils. Use of parameters specific to formulations will improve fate and transport predictions. C1 Univ Mississippi, Dept Chem Engn, Oxford, MS USA. USA, Engineer Res & Dev Ctr, Environm Proc Branch, Environm Lab, Vicksburg, MS 39180 USA. Comp Sci Corp, Vicksburg, MS USA. Univ Calif Riverside, Riverside, CA 92521 USA. RP Dontsova, KM (reprint author), Univ Mississippi, Dept Chem Engn, Oxford, MS USA. EM Kateryna.Dontsova@gmail.com RI Simunek, Jiri/F-3196-2011 NR 52 TC 44 Z9 44 U1 2 U2 17 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD NOV-DEC PY 2006 VL 35 IS 6 BP 2043 EP 2054 DI 10.2134/jeq2006.0007 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA 106XM UT WOS:000242135300010 PM 17071873 ER PT J AU Bowles, SV Bernard, RS Epperly, T Woodward, S Ginzburg, K Folen, R Perez, T Koopman, C AF Bowles, Stephen V. Bernard, Rebecca S. Epperly, Ted Woodward, Stephanie Ginzburg, Karni Folen, Raymond Perez, Theresita Koopman, Cheryl TI Traumatic stress disorders following first-trimester spontaneous abortion SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID PREGNANCY LOSS; MISCARRIAGE C1 Univ S Carolina, Dept Psychol, Walter Reed Army Med Ctr, Columbia, SC 29208 USA. Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. Univ Washington, Sch Med, Seattle, WA 98195 USA. Stanford PsyD Consortium, Sch Psychol, Palo Alto, CA USA. Tel Aviv Univ, Sch Social Work, IL-69978 Tel Aviv, Israel. Tripler Army Med Ctr, Dept Psychol, Honolulu, HI USA. Family Med Residency Idaho, Boise, ID USA. RP Bowles, SV (reprint author), Univ S Carolina, Dept Psychol, Walter Reed Army Med Ctr, Columbia, SC 29208 USA. EM sbowles@usuhs.mil NR 17 TC 8 Z9 8 U1 1 U2 2 PU DOWDEN PUBLISHING CORP PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD NOV PY 2006 VL 55 IS 11 BP 969 EP 973 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 110LD UT WOS:000242379500011 PM 17090356 ER PT J AU McDonald, KC Blackwell, JC AF McDonald, K. Colleen Blackwell, Jean C. TI What lifestyle changes should we recommend for the patient with newly diagnosed hypertension? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID RANDOMIZED CONTROLLED TRIALS; HIGH BLOOD-PRESSURE; AEROBIC EXERCISE; METAANALYSIS; PREVENTION; REDUCTION AB Hypertensive patients should reduce sodium intake (strength of recommendation [SOR]: A). The Dietary Approaches to Stop Hypertension diet (DASH diet)-with salt restriction and increased fruit, vegetable, calcium, and potassium intake-reduces blood pressure and should be recommended (SOR: A). Aerobic exercise is effective in the general, as well as elderly, populations for reducing blood pressure (SOR: A). Patients should be encouraged to reduce alcohol consumption (SOR: A). Evidence that weight loss is significantly associated with blood pressure reduction is inconclusive (SOR: C). Smoking cessation should be encouraged for all hypertensive patients for prevention of cardiovascular disease (SOR: A). C1 Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC USA. Univ N Carolina, Hlth Sci Lib, Chapel Hill, NC 27515 USA. RP McDonald, KC (reprint author), Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC USA. NR 12 TC 2 Z9 3 U1 0 U2 0 PU DOWDEN PUBLISHING CORP PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD NOV PY 2006 VL 55 IS 11 BP 991 EP 993 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 110LD UT WOS:000242379500016 PM 17090361 ER PT J AU Lin, XY Ruan, R Chen, P Chung, MS Ye, XF Yang, T Doona, C Wagner, T AF Lin, Xiangyang Ruan, Roger Chen, Paul Chung, Myongsoo Ye, Xiaofei Yang, Tom Doona, Chris Wagner, Tom TI NMR state diagram concept SO JOURNAL OF FOOD SCIENCE LA English DT Review DE glass transition; NMR; nuclear magnetic resonance; shelf-life; state diagram ID NUCLEAR-MAGNETIC-RESONANCE; GLASS-TRANSITION; MOLECULAR MOBILITY; WATER ACTIVITY; MICROBIOLOGICAL-GROWTH; FOOD POWDERS; CAKING; STABILITY; FORMULATIONS; DIFFUSION AB This article introduces a new concept, the NMR (nuclear magnetic resonance) state diagram, in the context of food shelf-life stability as affected by the molecular mobility of the food matrix. Our literature review shows that some shelf-life-related changes cannot be explained or predicted by the current a(w) and glass transition temperature concepts. This article presents the theoretical principles and some experimental evidence of the NMR, state diagram concept that could be complementary to the aw and glass transition concepts. An NMR state diagram is a curve of NMR relaxation time versus temperature. Some of the curve features were found to correlate highly to the physiochemical states and changes of food polymers, for example, caking, stickiness, and firming. The potential applications of this concept in quality and safety of food products, especially dry and intermediate moist foods, may include ingredients screening, prediction of physiochemical changes, chemical degradation, and microbiological activity. The goal concept of this article is to provoke more in-depth studies to analyze the relationships among NMR relaxation, molecular mobility, and stability of foods. C1 Nanchang Univ, MOE Key Lab Food Sci, Nanchang 330047, Jiangxi, Peoples R China. Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA. Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA. Solae Co, St Louis, MO 63188 USA. USA, Natick Soldier Syst Ctr, Natick, MA 01760 USA. RP Ruan, R (reprint author), Nanchang Univ, MOE Key Lab Food Sci, Nanchang 330047, Jiangxi, Peoples R China. EM ruanx001@umn.edu OI Ruan, Roger/0000-0001-8835-2649 NR 42 TC 17 Z9 17 U1 4 U2 19 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD NOV-DEC PY 2006 VL 71 IS 9 BP R136 EP R145 DI 10.1111/j.1750-3841.2006.00193.x PG 10 WC Food Science & Technology SC Food Science & Technology GA 112OB UT WOS:000242534600005 ER PT J AU Tenbrock, K Juang, YT Leukert, N Roth, J Tsokos, GC AF Tenbrock, Klaus Juang, Yuang-Taung Leukert, Nadja Roth, Johannes Tsokos, George C. TI The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity SO JOURNAL OF IMMUNOLOGY LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; C-FOS PROMOTER; T-CELLS; IL-2 PRODUCTION; TRICHOSTATIN-A; FACTOR CREB; BINDING; EXPRESSION; ACTIVATOR; CHROMATIN AB Transcriptional repression is a fundamental mechanism of gene regulation. cAMP response element (CRE) modulator (CREM)a is an ubiquitously expressed transcription factor and a counterpart of the activator CREB. In T cells, CREM is responsible for the termination of the IL-2 expression by a chromatin-dependent mechanism. We demonstrate in this study that CREM alpha associates with histone deacetylase (HDAC)1 through its H domain, which is located between the kinase inducible and DNA binding domains. The CREM alpha-mediated recruitment of HDAC1 to the CRE sites of the IL-2 and c-Fos promoter causes histone deacetylation and inaccessibility to restriction enzymes and limited transcriptional activity. Importantly, the CRE sites of these promoters are crucial for the activity and binding of HDAC1. Therefore, CREMa exerts its repressor activity by a mechanism that involves recruitment of HDAC1, increased deacetylation of histories, and repression of promoter activity. C1 Univ Munster, Inst Expt Dermatol, D-48149 Munster, Germany. Univ Munster, Univ Hosp, Div Rheumatol, Dept Pediat, D-48149 Munster, Germany. Univ Munster, Interdisciplinary Ctr Clin Res, Res Grp 5, D-48149 Munster, Germany. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. RP Tenbrock, K (reprint author), Univ Munster, Inst Expt Dermatol, Rontgenstr 21, D-48149 Munster, Germany. EM ktenbroc@uni-muenster.de FU NIAID NIH HHS [R01 AI 49954] NR 24 TC 32 Z9 34 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 1 PY 2006 VL 177 IS 9 BP 6159 EP 6164 PG 6 WC Immunology SC Immunology GA 097VN UT WOS:000241477400048 PM 17056544 ER PT J AU Sun, PF Celluzzi, CM Marovich, M Subramanian, H Eller, M Widjaja, S Palmer, D Porter, K Sun, W Burgess, T AF Sun, Peifang Celluzzi, Christina M. Marovich, Mary Subramanian, Hemavathy Eller, Michael Widjaja, Snsana Palmer, Dupeh Porter, Kevin Sun, Wellington Burgess, Timothy TI CD40 ligand enhances dengue viral infection of dendritic cells: A possible mechanism for T cell-mediated immunopathology SO JOURNAL OF IMMUNOLOGY LA English DT Article ID NECROSIS-FACTOR-ALPHA; TARGET DC-SIGN; NF-KAPPA-B; VIRUS-INFECTION; HEMORRHAGIC-FEVER; MYCOBACTERIUM-TUBERCULOSIS; STIMULATORY CAPACITY; INDUCED MATURATION; DISEASE SEVERITY; EXPRESSION AB We have previously shown that dengue virus (DV) productively infects immature human dendritic cells (DCs) through binding to cell surface DC-specific ICAM-3-grabbing nonintegrin molecules. Infected DCs are apoptotic, refractory to TNF-alpha stimulation, inhibited from undergoing maturation, and unable to stimulate T cells. In this study, we show that maturation of infected DCs could be restored by a strong stimulus, CD40L. Addition of CD40L significantly reduced apoptosis of DCs, promoted IL-12 production, and greatly elevated the IFN-gamma response of T cells, but yet did not restore T cell proliferation in MLR. Increased viral infection of DCs was also observed; however, increased infection did not appear to be mediated by DC-specific ICAM-3-grabbing nonintegrin, but rather was regulated by decreased production of IFN-alpha and decreased apoptotic death of infected DCs. Because CD40L is highly expressed on activated memory (but not naive) T cells, the observation that CD40L signaling results in enhanced DV infection of DC suggests a possible T cell-dependent mechanism for the immune-mediated enhancement of disease severity associated with some secondary dengue infections. C1 USN, Med Res Ctr, Silver Spring, MD 20910 USA. USN, Med Res Unit 2, Jakarta, Indonesia. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Univ Maryland, Sch Med, Baltimore, MD 21201 USA. Henry M Jackson Fdn, Rockville, MD 20852 USA. RP Burgess, T (reprint author), USN, Med Res Unit 2, FPO, AP USA. EM burgess@namru2.org RI Porter, Kevin/A-8027-2011 NR 53 TC 18 Z9 19 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 1 PY 2006 VL 177 IS 9 BP 6497 EP 6503 PG 7 WC Immunology SC Immunology GA 097VN UT WOS:000241477400086 PM 17056582 ER PT J AU Kheirabadi, BS Sieber, J Holcomb, JB AF Kheirabadi, Bijan S. Sieber, Jennifer Holcomb, John B. TI Assessment of the thrombogenic effect of fibrin sealant dressing in a vascular surgery model in rabbits SO JOURNAL OF INVESTIGATIVE SURGERY LA English DT Article DE animal model; fibrinogen; fibrin sealant; hemorrhage control; hemostatic dressing; rabbit; thrombin; thrombogenicity; vascular repair ID IN-111 PLATELET SCINTIGRAPHY; V LIVER-INJURIES; ADHESIVE BANDAGE; HEMOSTATIC EFFICACY; RANDOMIZED TRIAL; BLOOD-LOSS; DEPOSITION; THROMBIN; SWINE; GLUE AB This study's objective was to investigate the potential thrombogenic effects of thrombin-containing fibrin sealant dressings (FSD) in a vascular repair model. Oval-shaped pieces of the rabbit abdominal aorta and vena cava were excised, the injuries were repaired with FSD, and animals were allowed to recover. Thrombus formation was examined by (1) an infusion of indium-labeled platelets into the rabbits following FSD application and estimation of total number of platelets attached to the wounds at 2, 4, and 6 h later (short-term effect, n = 12); and by (2) morphological and histological examinations of the vessels and dressings on days 1, 3, and 7 after repair operation in another group of rabbits (long-term effect, n = 12). Application of FSD sealed the vascular injures and produced immediate hemostasis that was stable up to 1 week. The highest numbers of platelets (both native and labeled) adhered to the arterial and venous repair sites were 6.5 x 10(6) and 4.4 x 10(7), respectively, 6 h after operation. The adhered platelets, however, did not form a visible and clinically significant thrombus. In long- term experiments, no evidence of thrombus was found in the lumens of the repaired vessels or on the dressings, and no microthrombi were detected histologically in other tissues at any time point. Although vena caval injuries showed signs of healing at day 7 postoperatively, the aortic wounds expanded progressively (pseudoaneurysm) and were prone to rupture at later times. Thus, direct exposure of FSD does not cause intravascular thrombosis or thrombotic events in rabbits. The dressing appears to be safe and effective for short-term repair of vascular injuries. It may also allow healing of minor venous defects, but cannot replace conventional surgical techniques (suturing) for permanent repair of arterial damages. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Amer Red Cross, Holland Lab, Rockville, MD USA. RP Kheirabadi, BS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@cen.amedd.army.mil NR 41 TC 3 Z9 3 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0894-1939 J9 J INVEST SURG JI J. Invest. Surg. PD NOV-DEC PY 2006 VL 19 IS 6 BP 387 EP 396 DI 10.1080/08941930600985744 PG 10 WC Surgery SC Surgery GA 104WB UT WOS:000241990200008 PM 17101608 ER PT J AU Klun, JA Khrimian, A Rowton, E Kramer, M Debboun, M AF Klun, Jerome A. Khrimian, Ashot Rowton, Edgar Kramer, Matthew Debboun, Mustapha TI Biting deterrent activity of a Deet analog, two DEPA analogs, and SS220 applied topically to human volunteers compared with deet against three species of blood-feeding flies SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE N,N-diethyl-3-methylbenzamide; (1S,2 ' S)-methylpiperidinyl-3-cyclohexene-1-carboxamide; N,N-diethyl(3-bromophenyl)acetamide; N,N-diethyl[(alpha,alpha,alpha-trifluoro-m-tolyl)]acetamide; N,N,-diethyl [3-(trifluoromethyl)] benzamide ID MOSQUITO REPELLENTS; ANOPHELES-STEPHENSI; AEDES-AEGYPTI; SYSTEM; EFFICACY AB An earlier in vitro screening of N,N-diethyl-3-methylbenzamide (Deet) and N,N-diethylphenylacetamide (DEPA) analogs showed that two DEPA analogs, N,N-diethyl(3-bromophenyl) acetamide and N,N-diethyl [(alpha,alpha,alpha-trifluoro-m-tolyl)] acetamide, and one Deet analog, N,N,diethyl [3-(trifluoromethyl)] benzamide, had biting-deterrent activities that were superior to Deet against Aedes aegypti (L.) and Anopheles stephensi Liston. In the current study, the three analogs and (1S,2'S)-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) were applied topically to the skin of human volunteers at 24 nmol compound/cm(2) skin and compared with the activity of Deet at the same dose against biting by Ae. aegypti, An. stephensi, and Phlebotomus papatasi Scopoli females. SS220 proved to be as effective as Deet against Ae. aegypti and P. papatasi but more effective than Deet against An. stephensi. Contrary to the earlier in vitro tests, results with humans (in vivo testing) showed that neither of the DEPA analogs nor the Deet analog performed more effectively than Deet against the insects. The in vivo results showed that the analogs were not sufficiently effective to warrant further development. Notably, in vivo and in vitro methods used in discovery of personal protection chemicals for human use against blood-feeding flies can both be effective discriminating tools, but results obtained with the respective methods may not always agree. Ultimately, we surmise that in vivo testing methods with humans must be used to discriminate among compounds that superficially seem effective when screened using an in vitro method. C1 USDA ARS, PSI, BA, Chem Affecting Insect Behav Lab, Beltsville, MD 20705 USA. Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. USDA ARS, Biometrical Consulting Serv, BA, Beltsville, MD 20705 USA. USA, Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Acad Hlth Sci,Med Zool Branch, Ft Sam Houston, TX 78234 USA. RP Klun, JA (reprint author), USDA ARS, PSI, BA, Chem Affecting Insect Behav Lab, Beltsville, MD 20705 USA. EM klunj@ba.ars.usda.gov RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 17 TC 6 Z9 6 U1 1 U2 6 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2006 VL 43 IS 6 BP 1248 EP 1251 DI 10.1603/0022-2585(2006)43[1248:BDAOAD]2.0.CO;2 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 104BP UT WOS:000241931200020 PM 17162960 ER PT J AU Mantaring, MM Rhyne, J Miller, M AF Mantaring, M. M. Rhyne, J. Miller, M. TI Novel and common SNPs in the ABCA1 gene in association with low and high HDL-C SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Molecular-Pathology CY NOV 16-19, 2006 CL Orlando, FL SP Assoc Mol Pathol C1 Univ Maryland, Dept Med, Ctr Prevent Cardiol, Dept Med Prevent Cardiol, Baltimore, MD 21201 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD NOV PY 2006 VL 8 IS 5 BP 632 EP 632 PG 1 WC Pathology SC Pathology GA 102LF UT WOS:000241811800058 ER PT J AU Lesher, JD Sutlive, TG Miller, GA Chine, NJ Garber, MB Wainner, RS AF Lesher, Jonathan D. Sutlive, Thomas G. Miller, Giselle A. Chine, Nicole J. Garber, Matthew B. Wainner, Robert S. TI Development of a clinical prediction rule for classifying patients with patellofemoral pain syndrome who respond to patellar taping SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE bracing; knee pain; physical examination; physical therapy; rehabilitation ID CLOSED KINETIC CHAIN; ANTERIOR KNEE PAIN; MEDICAL LITERATURE; STAIR AMBULATION; CONTROLLED-TRIAL; MUSCLE-ACTIVITY; VISUAL ANALOG; USERS GUIDES; RELIABILITY; INDIVIDUALS AB Design: Predictive validity/diagnostic test study. Objective: To determine the predictive validity and interrater reliability of selected clinical exam items and to develop a clinical prediction rule (CPR) to determine which patients respond successfully to patellar taping. Background: Patellar taping is often used to treat patients with PFPS. However, the characteristics of the patients who respond best to patellar taping intervention have not been identified. Methods and Measures: Fifty volunteers (27 males, 23 females) with PFPS underwent a standardized clinical examination. Diagnosis of PFPS was based on the complaint of retropatellar pain that was provoked by a partial squat or stair ascent/descent. Subjects performed 3 functional activities and rated their pain during each activity on a numerical rating scale (NPRS). All subjects received treatment with a medial glide patellar-taping technique and repeated the functional activities and pain ratings. An immediate 50% reduction in pain or moderate improvement on a global rating of change (GRC) questionnaire was considered a treatment success. Likelihood ratios (LRs) were calculated to determine which examination items were most predictive of treatment outcome. Logistic regression analysis identified items included in the CPR. Results: Twenty-six subjects (52%) had an immediate successful response to the intervention. Two examination items (positive patellar tilt test or tibial varum greater than 5 degrees, +LR =4.4) comprised the CPR. Application of the CPR improved the probability of a successful outcome from 52% to 83%. Fifty-eight percent of the lower extremity measures were associated with moderate to good reliability (reliability coefficient range, 0.52-0.84). The reliability coefficients for the items that comprised the CPR were 0.49 (patellar tilt) and 0.66 (tibial varum). Conclusion: A CPR was developed to predict an immediate successful response to a medial glide patellar taping technique. Validation of the CPR in an independent sample is necessary before widespread clinical use can be recommended. C1 USA Baylor Univ Grad Program Phys Therapy, Ft Sam Houston, TX USA. Blanchfield Army Community Hosp, Ft Campbell, KY USA. USA Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. Darnall Army Community Hosp, Ft Hood, TX USA. Reynolds Army Community Hosp, Ft Sill, OK USA. Brooke Army Med Ctr, USA Baylor Univ Doctor Sci Program Orthoped Manua, Ft Sam Houston, TX 78234 USA. SW Texas State Univ, San Marcos, TX 78666 USA. RP Sutlive, TG (reprint author), 3151 Scott Rd,Suite 1230, Ft Sam Houston, TX 78234 USA. EM thomas.sutlive@cen.amedd.army.mil NR 71 TC 31 Z9 31 U1 0 U2 6 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2006 VL 36 IS 11 BP 854 EP 866 DI 10.2519/jospt.2006.2208 PG 13 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 103HM UT WOS:000241876300004 PM 17154139 ER PT J AU Tis, JE Sharif, S Shannon, B Dabney, K Miller, F AF Tis, John E. Sharif, Susan Shannon, Brian Dabney, Kirk Miller, Freeman TI Complications associated with multiple, sequential osteotomies for children with cerebral palsy SO JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B LA English DT Article DE cerebral palsy; complications; one-session surgery; severity score AB Children with cerebral palsy often require multiple, major reconstructive procedures. The purpose of this study was to evaluate whether multiple, major surgeries could be performed in a single setting with an acceptable complication rate. The medical records of 94 patients with a diagnosis of cerebral palsy operated on between the dates of 1993 and 1997 were reviewed. Patients were followed for a mean of 44.9 +/- 1.92 months. The average number of procedures per surgical session was 3.63 +/- 0.09 and the most common procedure performed was osteotomy of the proximal femur. The major complication rate was 24.4%. This institution's experience indicates that performance of multiple major bony procedures in one session is complicated but safe, and can be done with acceptable blood loss, infection rates and recurrence rates in a modern, multidisciplinary setting dedicated to the care of severely disabled children. J Pediatr Orthop B 15:408-413 (C) 2006 Lippincott Williams & Wilkins. C1 [Tis, John E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Sharif, Susan; Dabney, Kirk; Miller, Freeman] Alfred I DuPont Hosp Children, Dept Orthopaed Surg, Wilmington, DE USA. RP Tis, JE (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM john.tis@na.amedd.army.mil NR 19 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1060-152X J9 J PEDIATR ORTHOP B JI J. Pediatr. Orthop.-Part B PD NOV PY 2006 VL 15 IS 6 BP 408 EP 413 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA V80EP UT WOS:000205419900004 PM 17001246 ER PT J AU Coleman, JC Dobson, NR AF Coleman, J. C. Dobson, N. R. TI Diagnostic dilemma: extremely low birth weight baby with staphylococcal scalded-skin syndrome or toxic epidermal necrolysis SO JOURNAL OF PERINATOLOGY LA English DT Article DE staphylococcal scalded skin syndrome; premature infant; toxic epidermal necrolysis ID BULLOUS IMPETIGO; PRETERM INFANT AB Exfoliative skin diseases of the neonate are relatively rare but when present require rapid diagnosis and treatment to decrease morbidity and mortality associated with these entities. We present the case of a 795 g premature male infant who developed exfoliative lesions on day of life 66. Skin and blood cultures were obtained and intravenous antibiotics initiated. Results of a Tzanck smear suggested toxic epidermal necrolysis (TEN), so the infant was emergently transferred to a local children's hospital with burn unit capabilities for further care. Further histopathological evaluation of the skin biopsy confirmed the diagnosis of staphylococcal scalded-skin syndrome (SSSS). The desquamation ceased 24 h after the initiation of antibiotic therapy, and the skin lesions resolved within 10 days. We discuss the pathogenesis of SSSS and TEN and highlight the importance of early diagnosis so appropriate treatment can be initiated. C1 NNMC, NICU, Dept Pediat, Bethesda, MD 20889 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Dobson, NR (reprint author), NNMC, NICU, Dept Pediat, Bldg 10,6th Floor,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM ndobson@usuhs.mil NR 15 TC 3 Z9 5 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0743-8346 J9 J PERINATOL JI J. Perinatol. PD NOV PY 2006 VL 26 IS 11 BP 714 EP 716 DI 10.1038/sj.jp.7211599 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 103KP UT WOS:000241884400011 PM 17066068 ER PT J AU Hoekstra, A Maltsev, V Videen, G AF Hoekstra, A Maltsev, V Videen, G TI Special issue - Optics of biological particles - Preface SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material C1 Univ Amsterdam, NL-1098 Amsterdam, Netherlands. Russian Acad Sci, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia. USA, Res Lab, Adelphi, MD USA. RP Hoekstra, A (reprint author), Univ Amsterdam, Kruislaan 403, NL-1098 Amsterdam, Netherlands. EM alfons@science.uva.nl RI Maltsev, Valeri/B-4885-2009 OI Maltsev, Valeri/0000-0003-3478-5515 NR 2 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2006 VL 102 IS 1 BP 1 EP 2 DI 10.1016/j.jqsrt.2006.02.053 PG 2 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 058YU UT WOS:000238701300001 ER PT J AU Petrov, D Synelnyk, E Shkuratov, Y Videen, G AF Petrov, D Synelnyk, E Shkuratov, Y Videen, G TI The T-matrix technique for calculations of scattering properties of ensembles of randomly oriented particles with different size SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT NATO Advanced Research Workshop on Optics of Biological Particles CY OCT 03-06, 2005 CL Akademgorodok, RUSSIA SP NATO Sci Comm, Econova, Russian Fdn Basic Res, European Res Off USA, Off Naval Res Int Field Off, Russian Acad Sci, Siberian Branch, Inst Chem Kinet & Combust, Lab Cytometry & Biokinet DE light scattering; T-matrix method; Sh-matrix; irregular particles; negative polarization ID ELECTROMAGNETIC SCATTERING; LIGHT-SCATTERING AB We develop a modification of the T-matrix method that allows efficient studies of scattering properties of ensembles of independent irregular particles of different size. The advantage of the modification is quick calculations using the so-called shape-matrices (Sh-matrices), which allow more rapid calculations of scattering by particles of different size and can be used for averaging scattering properties over particle size. To illustrate the advantage we calculate the scattering-angle dependence of the intensity and degree of linear polarization of ensembles of cubes and Chebyshev particles of different size using both the new and traditional methods. Our time savings in calculating scattering properties for the particles with the new methodology is approximately a factor of ten when calculating scattering properties of one hundred of the same type of particles with different size parameter. As can be anticipated, increasing the size interval results in a smoothing of the structure of the photometric curves and a decrease in the linear polarization. Published by Elsevier Ltd. C1 Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. Space Sci Inst, Boulder, CO 80303 USA. RP Petrov, D (reprint author), Kharkov Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua NR 14 TC 33 Z9 34 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2006 VL 102 IS 1 BP 85 EP 110 DI 10.1016/j.jqsrt.2006.02.077 PG 26 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 058YU UT WOS:000238701300010 ER PT J AU Petrov, D Synelnyk, E Shkuratov, YG Videen, G Scotto, C Hart, M Eversole, J AF Petrov, D Synelnyk, E Shkuratov, YG Videen, G Scotto, C Hart, M Eversole, J TI Photopolarimetric properties of analytic models of some biological particles with irregular shape SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT NATO Advanced Research Workshop on Optics of Biological Particles CY OCT 03-06, 2005 CL Akademgorodok, RUSSIA SP NATO Sci Comm, Econova, Russian Fdn Basic Res, European Res Off USA, Off Naval Res Int Field Off, Russian Acad Sci, Siberian Branch, Inst Chem Kinet & Combust, Lab Cytometry & Biokinet ID LIGHT-SCATTERING; AGGLOMERATE PARTICLES AB We provide analytic descriptions of the morphologies of some biological particles: Sporisorium cruentum spores, Aspergillus terreus spores, and erythrocytes. We use the T-matrix extended-boundary-condition method to calculate the scattering properties of these particles. It is found that the morphology of A. terreus spores reveals an unusually wide negative polarization branch with two minima near large scattering angles, and that of S. cruentum spores do not display a negative polarization branch at all. We show that for unrealistically small size parameters, a simple cylinder has many of the same qualitative scattering properties of the much more complicated model of erythrocytes; however, as the particle size is made more realistic, very large differences appear in the scattering from these particle systems. Published by Elsevier Ltd. C1 VN Karazin Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. USN, Res Lab, Washington, DC 20375 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Petrov, D (reprint author), VN Karazin Kharkov Natl Univ, Astron Inst, Sumskaya Str 35, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua NR 15 TC 12 Z9 12 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2006 VL 102 IS 1 BP 111 EP 120 DI 10.1016/j.jqsrt.2006.02.076 PG 10 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 058YU UT WOS:000238701300011 ER PT J AU Pasquina, PF AF Pasquina, Paul F. TI National disabled veterans winter sports clinic SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Editorial Material ID PHYSICAL-ACTIVITY; EXERCISE C1 USA Med Corps, Washington, DC USA. Walter Reed Army Med Ctr, Amputee Program, Washington, DC 20307 USA. RP Pasquina, PF (reprint author), USA Med Corps, Washington, DC USA. EM paul.pasquina@na.amedd.army.mil NR 9 TC 2 Z9 2 U1 1 U2 8 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PD NOV-DEC PY 2006 VL 43 IS 7 BP XI EP XV DI 10.1682/JRRD.2006.08.0099 PG 5 WC Rehabilitation SC Rehabilitation GA 156FO UT WOS:000245633700002 PM 17436166 ER PT J AU Gosztyla, AE Edwards, DG Quinn, TJ Kenefick, RW AF Gosztyla, Amy E. Edwards, David G. Quinn, Timothy J. Kenefick, Robert W. TI The impact ofdifferent pacing strategies on five-kilometer running time trial performance SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE road racing; runners; performance ID LACTATE; RUNS AB The purpose of this study was to determine the optimal 1.63-km (1-mile) pacing strategy for 5-km running performance in moderately trained women distance runners. Eleven women distance runners (20.7 +/- 0.8 years, 163.8 +/- 2.0 cm, 57.0 +/- 2.2 kg, 51.7 +/- 1.0 ml.kg(-1).min(-1), 18.9 +/- 0.8% fat, 78.1 +/- 1.4% (V) over dot o(2)max at lactate threshold) performed 2 preliminary 5-km time trials on a treadmill to establish baseline 5-km times. The average 1.63-km split pace of the fastest preliminary trial was manipulated for the first 1.63 km of the experimental trials and run either equal to (EVEN), 3% faster than (3%), or 6% faster than (6%) the current baseline average 1.63-km pace for each subject. Ventilation (V-E), oxygen consumption ((V) over dot o(2)), respiratory exchange ratio, and heart rate were measured continuously. Overall 5-km times were not different (p > 0.05) for the EVEN, 3% and 6% trials finishing in 21:11 (minutes/seconds) +/- 29 seconds, 20:52 +/- 36 seconds and 20:39 +/- 29 seconds, respectively. The fastest time for 8 subjects resulted from the 6% trial and the other 3 subjects' fastest times resulted from the 3% trial. The overall exercise intensity (0%(V) over dot o(2)max, %(V) over dot o(2)max above lactate threshold, V-E, and respiratory exchange ratio) of the first 1.63-km split was not different between the 3 and 6% trials, despite the 6% trial being 13 seconds faster than the 3% trial. Based on these findings, initial 1.63-km starting paces of a 5-km race can be 3 to 6% greater than current average race pace without negatively impacting performance. In order to optimize 5-km performance, runners should start the initial 1.63 kin of a 5-km race at paces 3-6% greater than their current average race pace. C1 Univ New Hampshire, Dept Kinesiol, Exercise Physiol Lab, Durham, NH 03824 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 19 TC 21 Z9 22 U1 2 U2 8 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2006 VL 20 IS 4 BP 882 EP 886 DI 10.1519/R-19275.1 PG 5 WC Sport Sciences SC Sport Sciences GA 110XJ UT WOS:000242414300026 PM 17149992 ER PT J AU Marquart, JD Trakimas, CA Sawchuk, WS Nuovo, GJ de Villiers, EM Turiansky, GW AF Marquart, Jason D. Trakimas, Carol A. Sawchuk, William S. Nuovo, Gerard J. de Villiers, Ethel-Michele Turiansky, George W. TI Human papillomavirus 57-induced extensive, recalcitrant cutaneous verrucae SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID 2/27/57-INDUCED COMMON WARTS; ANTIGEN CLASS-II; INFECTION; RISK C1 Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. Womack Army Med Ctr, Dermatol Clin, Ft Bragg, NC USA. Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA. Deutsch Krebsforschungszentrum, Div Tumorvirus Characterizat, Heidelberg, Germany. RP Turiansky, GW (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.turiansky@na.amedd.army.mil NR 11 TC 4 Z9 4 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 2006 VL 55 IS 5 BP 907 EP 908 DI 10.1016/j.jaad.2006.06.037 PG 2 WC Dermatology SC Dermatology GA 099LL UT WOS:000241596000027 PM 17052505 ER PT J AU Tomaszewski, MM Marquart, LN Turiansky, GW Lupton, GP AF Tomaszewski, Maria-Magdalena Marquart, Laura N. Turiansky, George W. Lupton, George P. TI Primary malignant mesothelioma presenting as an umbilical tumor SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter C1 Armed Forces Inst Pathol, Dept Dermatopathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Serv Dermatol, Washington, DC 20307 USA. RP Tomaszewski, MM (reprint author), Armed Forces Inst Pathol, Dept Dermatopathol, Bldg 54,Room G066, Washington, DC 20306 USA. EM tomaszew@afip.osd.mil NR 6 TC 1 Z9 1 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 2006 VL 55 IS 5 SU S BP S101 EP S102 DI 10.1016/j.jaad.2005.09.031 PG 2 WC Dermatology SC Dermatology GA 101JD UT WOS:000241736200014 PM 17052517 ER PT J AU Cannard, K AF Cannard, Kevin TI The acute treatment of nerve agent exposure SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article; Proceedings Paper CT 18th World Congress of Neurology CY NOV 05-11, 2005 CL Sydney, AUSTRALIA DE nerve agent; sarin; tabun; Soman; VX; acetylcholine esterase; atropine; oxime ID TOKYO SUBWAY; CHEMICAL WARFARE; SARIN VAPOR; GAS; ATROPINE; ATTACK; MATSUMOTO; CHILDREN; SOMAN; STAFF AB Nerve agents (NA) are simple and cheap to produce but can produce casualties on a massive scale. They have already been employed by terrorist organizations and rogue states on civilians and armed forces alike. By inhibiting the enzyme acetylcholine esterase, NAs prevent the breakdown of the neurotransmitter acetylcholine. This results in over-stimulation of muscarinic and nicotinic receptors in the autonomic and central nervous systems and at the neuromuscular junction. Increased parasympathetic stimulation produces miosis, sialorrhea, bronchospasm and bronchorrhea. Effects at the neuromuscular junction cause weakness, fasciculations, and eventually paralysis. Central effects include altered behavior and mental status, loss of consciousness, seizures, or apnea. Most deaths are due to respiratory failure. Treatment with atropine competitively blocks the parasympathetic effects. Oximes like pralidoxime salvage acetylcholine esterase by "prying off" NA, provided the attachment has not "aged" to an irreversible bond. This reverses weakness. Benzodiazepines like diazepam are effective against NA induced seizures. Mortality has been surprisingly low. If victims can survive the first 15 to 20 min of a vapor attack, they will likely live. The low mortality rate to date underscores that attacks are survivable and research reveals even simple barriers such as clothing offer substantial protection. This article reviews the properties of NAs and how to recognize the clinical features of NA intoxication, employ the needed drugs properly, and screen out anxious patients who mistakenly believe they have been exposed. Published by Elsevier B.V. C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Bethesda, MD 20814 USA. RP Cannard, K (reprint author), 4012 Dresden St, Kensington, MD 20895 USA. EM kevin.cannard@na.amedd.army.mil NR 37 TC 61 Z9 63 U1 1 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 1 PY 2006 VL 249 IS 1 BP 86 EP 94 DI 10.1016/j.jns.2006.06.008 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 111RP UT WOS:000242472300014 PM 16945386 ER PT J AU Alvarado, JL Marsh, C Sohn, C Vilceus, M Hock, V Phetteplace, G Newell, T AF Alvarado, J. L. Marsh, C. Sohn, C. Vilceus, M. Hock, V. Phetteplace, G. Newell, T. TI Characterization of supercooling suppression of microencapsulated phase change material by using DSC SO JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY LA English DT Article DE cooling rate; crystallization point; DSC; latent heat of fusion; melting point; microencapsulated phase change material ID CHANGE MATERIAL SUSPENSIONS; CONVECTION HEAT-TRANSFER; CHANGE-MATERIAL SLURRIES; MINIEMULSION DROPLETS; COOL STORAGE; CRYSTALLIZATION; SYSTEMS; POLYPROPYLENE; TETRADECANE; HEXADECANE AB Supercooling suppression of microencapsulated n-tetradecane was measured using differential scanning calorimetry. Results indicate that the degree of supercooling is positively affected by the amount and type of nucleating agent present in bulk and microencapsulated n-tetradecane which it is used as a phase change material (MPCM). Results also demonstrate that the melting point of the n-tetradecane is fairly independent of nucleating agent concentration (0 - 4%). Conversely, the latent heat of fusion of n-tetradecane decreases considerably with nucleating agent amount and the initiation of crystallization point is inversely proportional to cooling rate. C1 Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. Univ Illinois, Dept Mech & Ind Engn, Urbana, IL 61801 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, 117 Thompson Hall,3367 TAMU, College Stn, TX 77843 USA. EM Alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 NR 28 TC 48 Z9 51 U1 1 U2 27 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-6150 J9 J THERM ANAL CALORIM JI J. Therm. Anal. Calorim. PD NOV PY 2006 VL 86 IS 2 BP 505 EP 509 DI 10.1007/s10973-005-7430-0 PG 5 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA 094EK UT WOS:000241222100032 ER PT J AU Walters, T Baer, DG Kauvar, DS AF Walters, Thomas Baer, David G. Kauvar, David S. TI A large animal fatal extremity hemorrhage model and evaluation of a polymeric dressing (fatal extremity hemorrhage) SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID HEMOSTATIC DRESSINGS; VENOUS HEMORRHAGE; HEPATIC-INJURY; GROIN INJURY; BLOOD-LOSS; US ARMY; SWINE; BATTLEFIELD; CASUALTIES; SURVIVAL AB Background: Extremity hemorrhage is a contributor to preventable battlefield mortality. The Army has liberalized tourniquet use guidelines in an attempt to prevent these deaths. To evaluate wound hemostatic agents that might allow for early tourniquet removal while maintaining hemorrhage control, a model of lethal extremity hemorrhage in the goat (Capra hircus) was developed and a polymeric dressing agent (RioFoam) tested. Methods: After administration of a spinal block, animals were placed in lateral recumbancy with a head-up tilt of 6 degrees, 500 mL crystalloid was injected and 600 u/Kg of heparin was administered. After tourniquet application to the thigh, a soft tissue and vascular injury was created by transecting muscles and the femoral artery. The polymeric wound dressing was applied and the tourniquet was released. Results: In testing, the primary endpoint was mortality within the first hour after tourniquet release. None of the control animals survived the full hour. Two out of five (40%) of the treated animals survived. With survivors' survival time calculated as 60 minutes, survival time was found not to differ between treated (34 19 minutes) and untreated (29 18 minutes) animals (p = 0.77). Conclusion: The physical characteristics of tissue injury, need for anticoagulation, and manipulation of blood pressure are vital factors contributing to the lethality of a large animal fatal extremity hemorrhage model. BioFoam was successful in preventing fatal arterial extremity hemorrhage after the release of an effective tourniquet in some cases. An agent that can reliably allow for safe tourniquet removal and restoration of collateral circulation is a potential solution to tourniquet-associated morbidity in traumatic extremity injury. The model developed will serve as a rigorous test for such agents. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Walters, T (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Suite B,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM thomas.walters@amedd.army.mil NR 23 TC 6 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2006 VL 61 IS 5 BP 1107 EP 1112 DI 10.1097/01.ta.0000195655.30837.29 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 105TB UT WOS:000242054100012 PM 17099515 ER PT J AU Barry, JD Ervin, M Molstad, J Wickenden, A Brintlinger, T Hoffman, P Melngailis, J AF Barry, John D. Ervin, Matthew Molstad, Jay Wickenden, Alma Brintlinger, Todd Hoffman, Patrik Melngailis, John TI Electron beam induced deposition of low resistivity platinum from Pt(PF3)(4) SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 50th International Conference on Electron, Ion, and Photon Beam Technology and Nanofabrication CY MAY 30-JUN 02, 2006 CL Baltimore, MD SP AVS, IEEE Electron Devices Soc, Opt Soc Amer ID CHEMICAL VAPOR-DEPOSITION; GOLD AB The authors have deposited Pt from Pt(PF3)(4) using a focused 10 keV electron beam (scanning electron microscopy) in an FEI 620 dual beam system and measured the resistivity and composition of the deposits. To measure resistivity, lines of Pt were deposited across four gold fingers and the cross-sectional area of the lines was measured by focused ion beam sectioning. The resistivity varies between about 30 and 650 mu Omega cm and is orders of magnitude lower than the resistivity achieved by e-beam-induced deposition using the usual organometallic precursor, (methylcyclopentadienyl) trimethyl platinum. In general, the higher the beam current the lower the resistivity. They have used wavelength dispersive x-ray analysis to measure the composition of rectangles deposited with various beam currents. Typical at.% values of (Pt:P:F) are 81:17:2 and 58:32:10. Minimum linewidth that they have deposited is 80 nm, and with a stationary beam of 2.8 nA they have deposited a pillar of 135 nm in diameter. They have also deposited Pt structures on freestanding carbon nanotubes and have used the deposits to contact nanofibers. Electron-beam-induced deposition of a "good" metal is particularly useful in geometries where standard lithography is awkward, such as making contacts to fibers or nanotubes randomly dispersed on a surface or freestanding. (c) 2006 American Vacuum Society. C1 [Barry, John D.; Brintlinger, Todd; Hoffman, Patrik; Melngailis, John] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Ervin, Matthew; Molstad, Jay; Wickenden, Alma; Brintlinger, Todd] USA, Res Lab, AMSRD, ARL,SE,RL, Adelphi, MD 20783 USA. [Hoffman, Patrik] Ecole Polytech Fed Lausanne, Adv Photon Lab, CH-1015 Lausanne, Switzerland. RP Barry, JD (reprint author), Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. EM jdbarry@umd.edu; melng@umd.edu RI Hoffmann, Patrik/I-5341-2012 NR 15 TC 35 Z9 35 U1 0 U2 5 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV-DEC PY 2006 VL 24 IS 6 SI SI BP 3165 EP 3168 DI 10.1116/1.2395962 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 123VO UT WOS:000243324400127 ER PT J AU Watkins, DW Moser, DA AF Watkins, David W., Jr. Moser, David A. TI Economic-based optimization of Panama Canal system operations SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article DE economic factors; optimization; Panama Canal; water flow ID RESERVOIR; RULES; WATER AB A network flow optimization model is developed to study the operations of the Panama Canal system. The prescriptive model chooses monthly reservoir releases and storage levels that maximize the overall benefit of the system. Solution of the model relies on penalty functions that relate value (either economic or noneconomic) to storage levels, releases, and flows in the system. Penalty functions are developed for the multiple purposes of the system, including water supply, navigation, hydroelectric power generation, and flood control. Patterns observed in the model results can serve as starting points to develop improved operating rules for the existing system, and the model can also help evaluate the potential benefits of structural changes to the system. The primary operational trade-off evaluated herein is between maximizing hydroelectric power generation and meeting navigation requirements with a high degree of reliability. Model results also provide some insights into the capacity expansion decisions faced by the Panama Canal Authority. C1 Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. USA, Corps Engineers, Alexandria, VA 22315 USA. Inst Water Resources, Alexandria, VA 22315 USA. RP Watkins, DW (reprint author), Michigan Technol Univ, Dept Civil & Environm Engn, 1400 Townsend Dr, Houghton, MI 49931 USA. EM dwatkins@mtu.edu; david.a.moser@usace.army.mil NR 20 TC 10 Z9 10 U1 3 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD NOV-DEC PY 2006 VL 132 IS 6 BP 503 EP 512 DI 10.1061/(ASCE)0733-9496(2006)132:6(503) PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 099DW UT WOS:000241573700011 ER PT J AU Cleland, JA Childs, JD Palmer, JA Eberhart, S AF Cleland, Joshua A. Childs, John D. Palmer, Jessica A. Eberhart, Sarah TI Slump stretching in the management of non-radicular low back pain: A pilot clinical trial SO MANUAL THERAPY LA English DT Article DE low back pain; neurodynamics; slump test; slump stretching ID LOWER-EXTREMITY SYMPTOMS; FEAR-AVOIDANCE BELIEFS; CENTRALIZATION PHENOMENON; NEURAL MOBILIZATION; SPINAL MANIPULATION; PRACTICE GUIDELINES; PREDICTION RULE; DISABILITY; EXERCISE; QUESTIONNAIRE AB The purpose of this study was to determine if slump stretching results in improvements in pain, centralization of symptoms, and disability in patients with non-radicular low back pain (LBP) with likely mild to moderate neural mechanosensitivity. Thirty consecutive patients referred to physical therapy by their primary care physician for LBP who met all eligibility criteria including a positive slump test but who had a negative straight-leg-raise test (SLR) agreed to participate in the study. All patients completed several self-report measures including a body diagram, numeric pain rating scale (NPRS), and the modified Oswestry Disability Index (ODI). Patients were randomized to receive lumbar spine mobilization and exercise (n = 14) or lumbar spine mobilization, exercise, and slump stretching (n = 16). All patients were treated in physical therapy twice weekly for 3 weeks for a total of 6 visits. Upon discharge, outcome measures were re-assessed. Independent t-tests were used to assess differences between groups at baseline and discharge. No baseline differences existed between the groups (P >.05). At discharge, patients who received slump stretching demonstrated significantly greater improvements in disability (9.7 points on the 0131, P <.001), pain (.93 points on the NPRS, P =.001), and centralization of symptoms (P <.01) than patients who did not. The results suggest that slump stretching is beneficial for improving short-term disability, pain, and centralization of symptoms. Future studies should examine whether these benefits are maintained at a longer-term follow-up. (c) 2005 Elsevier Ltd. All rights reserved. C1 Franklin Pierce Coll, Phys Therapy Program, Concord, NH 03301 USA. Concord Hosp, Rehabil Serv, Concord, NH 03301 USA. Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. Concord Hosp, Rehabil Serv, Ctr Sports Med, Concord, NH USA. RP Cleland, JA (reprint author), Franklin Pierce Coll, Phys Therapy Program, 5 Chenell Dr, Concord, NH 03301 USA. EM clelandj@fpc.edu NR 40 TC 25 Z9 27 U1 1 U2 14 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X J9 MANUAL THER JI Man. Ther. PD NOV PY 2006 VL 11 IS 4 BP 279 EP 286 DI 10.1016/j.math.2005.07.002 PG 8 WC Rehabilitation SC Rehabilitation GA 115FV UT WOS:000242721100006 PM 16380286 ER PT J AU Childs, JD Flynn, TW Fritz, JM AF Childs, John D. Flynn, Timothy W. Fritz, Julie M. TI A perspective for considering the risks and benefits of spinal manipulation in Patients with low back pain SO MANUAL THERAPY LA English DT Article DE relative risk; physical therapy; manual therapy; UKBEAM ID CLINICAL-PRACTICE; THERAPY; MANAGEMENT; OUTCOMES; TREAT AB The purpose of this study was to determine if patients who do not receive manipulation for their low back pain (LBP) are at an increased risk for worsening disability compared to patients receiving an exercise intervention without manipulation. One hundred and thirty-one consecutive patients with LBP were randomly assigned to receive manipulation and an exercise intervention (n = 70) or an exercise intervention without manipulation (n = 61). Patients were classified as to whether they had experienced a worsening in disability upon follow-up. Relative risk and number needed to treat (NNT) statistics and associated 95% confidence intervals (CI) were calculated. Patients who completed the exercise intervention without manipulation were eight (95% Cl: 1. 1, 63.5) times more likely to experience a worsening in disability than patients who received manipulation. The NNT with manipulation to prevent one additional patient from experiencing a worsening in disability was 9.9 (95% Cl: 4.9, 65.3) and 4 weeks with manipulation was 11.6 (95% Cl: 5.2, 219.2). The results of this study offer an additional perspective for considering the risks and benefits of spinal manipulation and help to inform the integration of current evidence for spinal manipulation into healthcare policy. Published by Elsevier Ltd. C1 Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. Univ Utah, Div Phys Therapy, Salt Lake City, UT 84112 USA. Intermt Healthcare, Salt Lake City, UT 84112 USA. RP Childs, JD (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, 3151 Scott Rd, Ft Sam Houston, TX 78234 USA. NR 21 TC 10 Z9 10 U1 0 U2 1 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X J9 MANUAL THER JI Man. Ther. PD NOV PY 2006 VL 11 IS 4 BP 316 EP 320 DI 10.1016/j.math.2005.09.002 PG 5 WC Rehabilitation SC Rehabilitation GA 115FV UT WOS:000242721100010 PM 16839800 ER PT J AU Blunt, DM Keller, JA AF Blunt, David M. Keller, Jonathan A. TI Detection of a fatigue crack in a UH-60A planet gear carrier using vibration analysis SO MECHANICAL SYSTEMS AND SIGNAL PROCESSING LA English DT Article DE vibration; epicyclic; planet; gear; helicopter; fatigue crack AB Two new methods of detecting a fatigue crack in a planet carrier of an epicyclic transmission are developed. These are tested using vibration data from a number of US Army UH-60A Black Hawk helicopter main transmissions. Vibration measurements of faulted and un-faulted transmissions over a range of torque levels in controlled test-cell and on-aircraft conditions are used. The results show that new methods are reliable under test-cell conditions, but less effective under low-torque on-aircraft conditions. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved. C1 Def Sci & Technol Org, Dept Def, Fishermans Bend, Vic 3207, Australia. USA, RDECOM, Aviat Engn Directorate, Redstone Arsenal, AL 35898 USA. RP Blunt, DM (reprint author), Def Sci & Technol Org, Dept Def, 506 Lorimer St, Fishermans Bend, Vic 3207, Australia. EM david.blunt@dsto.defence.gov.au; jonathan.a.keller@us.army.mil NR 23 TC 40 Z9 46 U1 3 U2 10 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0888-3270 J9 MECH SYST SIGNAL PR JI Mech. Syst. Signal Proc. PD NOV PY 2006 VL 20 IS 8 BP 2095 EP 2111 DI 10.1016/j.ymssp.2006.05.010 PG 17 WC Engineering, Mechanical SC Engineering GA 084SZ UT WOS:000240556000017 ER PT J AU Morris, MJ AF Morris, Michael James TI Acute respiratory distress syndrome in combat casualties: Military medicine and advances in mechanical ventilation SO MILITARY MEDICINE LA English DT Article ID ACUTE PULMONARY-EDEMA; MASSIVE COLLAPSE; INSUFFICIENCY; PRESSURE; TRAUMA; LUNG; THERAPY; RECOMMENDATIONS; COMPLICATIONS; PERSPECTIVE AB Military medicine has made numerous enduring contributions to the advancement of pulmonary medicine. Acute respiratory distress syndrome was first recognized as a complication in battlefield casualties in World War I and continued to play a significant role in the treatment of casualties through the Vietnam War. Innovative surgeons during World War II devised methods to assist their patients with positive pressure breathing. This concept was later adopted and applied to the development of mechanical ventilation in the late 1940s and early 1950s. The continued treatment of acute respiratory distress syndrome in combat casualties by military physicians has provided a major impetus for advances in modern mechanical ventilation and intensive care unit medicine. C1 Brooke Army Med Ctr, Pulm Dis Crit Care Serv, Ft Sam Houston, TX 78234 USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Pulm Dis Crit Care Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 49 TC 10 Z9 10 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1039 EP 1044 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700004 PM 17153538 ER PT J AU Darakjy, S Marin, RE Knapik, JJ Jones, BH AF Darakjy, Salima Marin, Roberto E. Knapik, Joseph J. Jones, Bruce H. TI Injuries and illnesses among armor brigade soldiers during operational training SO MILITARY MEDICINE LA English DT Article ID MILITARY OPERATIONS; INFANTRY SOLDIERS; SURVEILLANCE; PREVENTION; DISEASE; POPULATIONS; PREVALENCE; BATTLE; RATES; NAVY AB This study describes injury and illness rates and some risk factors among soldiers from an armor division during a rotation at the National Training Center (Fort Irwin, California). Soldiers from a brigade of the 1st Cavalry Division were involved in a 5-week training exercise at the National Training Center. Health care visits were systematically recorded by the unit medics. Of 4, 101 men and 413 women who participated in the exercise, 504 soldiers (409 men and 95 women) sought medical care at the main support medical clinic or Weed Army Community Hospital. The rates of injury and illness visits were 1.2% and 0.6% per week for men and 2.3% and 2.2% per week for women, respectively. Women had twice the risk of an injury and 3.5 times the risk of an illness, compared with men. Compared with other branches, combat service support soldiers had higher rates of injuries and illnesses. Enlisted soldiers of lower rank (E1-E4) experienced higher injury and illness rates than did noncommissioned officers and commissioned officers. Musculoskeletal injuries, environmental conditions, and dermatological conditions accounted for most visits. C1 USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. USA, Cavalry Div 1, Brigade Combat Team 2, Ft Hood, TX 76544 USA. RP Darakjy, S (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. NR 23 TC 11 Z9 12 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1051 EP 1056 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700006 PM 17153540 ER PT J AU Bowles, SV Picano, J Epperly, T Myer, S AF Bowles, Stephen V. Picano, James Epperly, Ted Myer, Stephanie TI The LIFE program: A wellness approach to weight loss SO MILITARY MEDICINE LA English DT Article ID OBESITY TREATMENT PROGRAM; FOLLOW-UP; OVERWEIGHT; EXERCISE; WOMEN AB The LIFE (lifestyle change, individual readiness, fitness excellence, eating healthy) wellness program was an intensive, outpatient, healthy lifestyle change program with participants from the Army, Navy, Air Force, and Marine Corps. Our objective was to describe the LIFE program and to present before and after test results for this 1-year program. Fifty-three participants completed the 5-day intensive outpatient and 1-year follow-up program and maintained average weight losses of >10 pounds and 14 pounds for men and women, respectively. Most of the weight loss occurred by 6 months. Participants who completed the program also showed increases in healthy eating attitudes, well-being, and overall quality of life. The LIFE change model has implications for improved service retention, health, and overall quality of life or patient evidence that matters (POEMS). The program is both portable and flexible and can be tailored to the demands of the dynamic military environment. C1 Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20307 USA. Dept Vet Affairs No Calif, Dept Psychol, Martinez, CA 94553 USA. Family Med Residency Idaho, Boise, ID 83704 USA. Univ Washington, Sch Med, Seattle, WA 98101 USA. Madigan Army Med Ctr, Nutr Care Div, Tacoma, WA 98431 USA. RP Bowles, SV (reprint author), Univ S Carolina, Sch Med, Columbia, SC 29208 USA. NR 26 TC 15 Z9 15 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1089 EP 1094 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700013 PM 17153547 ER PT J AU Wojcik, BE Stein, CR Devore, RB Hassell, H AF Wojcik, Barbara E. Stein, Catherine R. Devore, Raymond B. Hassell, Harrison TI The challenge of mapping between two medical coding systems SO MILITARY MEDICINE LA English DT Article ID AGREEMENT AB Objective: Deployable medical systems patient conditions (PCs) designate groups of patients with similar medical conditions and, therefore, similar treatment requirements. PCs are used by the U.S. military to estimate field medical resources needed in combat operations. Information associated with each of the 389 PCs is based on subject matter expert opinion, instead of direct derivation from standard medical codes. Currently, no mechanisms exist to tie current or historical medical data to PCs. Our study objective was to determine whether reliable conversion between PC codes and International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) diagnosis codes is possible. Methods: Data were analyzed for three professional coders assigning all applicable ICD-9-CM diagnosis codes to each PC code. Inter-rater reliability was measured by using Cohen's kappa statistic and percent agreement. Methods were developed to calculate kappa statistics when multiple responses could be selected from many possible categories. Results: Overall, we found moderate support for the possibility of reliable conversion between PCs and ICD-9-CM diagnoses (mean kappa = 0.61). Conclusion: Current PCs should be modified into a system that is verifiable with real data. C1 USA, Med Dept Ctr & Sch, Ctr Army Med Dept Strateg Studies, Ft Sam Houston, TX 78234 USA. RP Wojcik, BE (reprint author), USA, Med Dept Ctr & Sch, Ctr Army Med Dept Strateg Studies, Ft Sam Houston, TX 78234 USA. NR 6 TC 1 Z9 1 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1128 EP 1136 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700021 PM 17153555 ER PT J AU Niebuhr, DW Otto, WC Niebuhr, DW Powers, TE Krauss, MR McVeigh, FL Tarbett, AK AF Niebuhr, David W. Otto, William C. Niebuhr, David W. Powers, Timothy E. Krauss, Margot R. McVeigh, Francis L. Tarbett, Aaron K. TI Attrition of military enlistees with a medical waiver for myopia, 1999-2001 SO MILITARY MEDICINE LA English DT Article ID PROGRESSION; LENSES; TRIAL AB Background: Military service requires physical fitness, including vision within set standards. Premature attrition inflicts a considerable manpower and fiscal burden upon the military. Methods: We conducted a retrospective cohort survival analysis of newly enlisted military personnel who entered active duty with a medical waiver for myopia between January 1, 1999, and December 31, 2001. Premature attrition rates, both medical and overall, were compared with those for a matched, fully qualified, comparison group. Results: New enlistees with a waiver for myopia had the same probability of remaining on active duty through the first 2 years of service as did fully qualified peers. Enlistees with a waiver for myopia also had a low probability of an early medical discharge for myopia. Conclusion: The results of this study tend to validate the current branch-specific myopia waiver processes. They also provide evidence that current myopia accession criteria may be too restrictive and in need of policy review. C1 Uniformed Serv Univ Hlth Sci, Div Biometr & Prevent Med, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Niebuhr, DW (reprint author), Uniformed Serv Univ Hlth Sci, Div Biometr & Prevent Med, Bethesda, MD 20814 USA. RI Niebuhr, David/B-7865-2011 NR 9 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1137 EP 1141 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700022 ER PT J AU Niebuhr, DW Powers, TE Krauss, MR Cuda, S Johnson, BM AF Niebuhr, David W. Powers, Timothy E. Krauss, Margot R. Cuda, S. Johnson, Bryan M. TI A review of initial entry training discharges at Fort Leonard Wood, MO, for accuracy of discharge classification type: Fiscal year 2003 SO MILITARY MEDICINE LA English DT Review ID NAVY ATTRITION; US MILITARY; PREDICTORS AB Objective: This study examines the extent to which discharges from Initial Entry Training can be adequately characterized by the current policy of a single descriptive category. Methods: Service records of each trainee discharged from Fort Leonard Wood in 2003 were examined. Discharged trainee's counseling and outpatient clinic visit records were reviewed for evidence of multiple reasons for discharge. Results: Evidence of medical involvement was found by record review in 13% of administrative discharges. Among discharges classified as being for medical or physical conditions that did not exist before service, 17% had clear evidence of preexisting chronic conditions. Conclusion: The policy of allowing only one categorization code to describe reasons for an Initial Entry Training discharge frequently resulted in incomplete characterization of factors leading to discharge. Pre-existing medical and mental health conditions were found in a much greater percentage of discharges than indicated by a simple review of discharge codes. C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. Tripler Army Med Ctr, Dept Family Practice, Honolulu, HI 96859 USA. Eisenhower Reg Med Ctr, Ft Gordon, GA 30905 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011 NR 9 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2006 VL 171 IS 11 BP 1142 EP 1146 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 105HJ UT WOS:000242020700023 PM 17153557 ER PT J AU Alving, CR Beck, Z Karasavva, N Matyas, GR Rao, M AF Alving, Carl R. Beck, Zoltan Karasavva, Nicos Matyas, Gary R. Rao, Mangala TI HIV-1, lipid rafts, and antibodies to liposomes: implications for anti-viral-neutralizing antibodies (Review) SO MOLECULAR MEMBRANE BIOLOGY LA English DT Review DE HIV-1; neutralization; lipid rafts; liposomes ID HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 ENVELOPE GLYCOPROTEIN; C-TERMINAL REGION; MONOCLONAL-ANTIBODIES; GALACTOSYL CERAMIDE; CELL-MEMBRANES; ANTIPHOSPHOLIPID ANTIBODIES; CHOLESTEROL ANTIBODIES; AMPHIPATHIC PEPTIDE; CHEMOKINE RECEPTORS AB The human immunodeficiency virus type 1 (HIV-1) is an enveloped virus with a lipid bilayer that contains several glycoproteins that are anchored in, or closely associated with, the membrane surface. The envelope proteins have complex interactions with the lipids both on the host cells and on the target cells. The processes of budding from host cells and entry into target cells occur at sites on the plasma membrane, known as lipid rafts, that represent specialized regions that are rich in cholesterol and sphingolipids. Although the envelope glycoproteins are antigenic molecules that potentially might be used for development of broadly neutralizing antibodies in a vaccine to HIV-1, the development of such antibodies that have broad specificities against primary field isolates of virus has been largely thwarted to date by the ability of the envelope proteins to evade the immune system through various mechanisms. In this review, the interactions of HIV-1 with membrane lipids are summarized. Liposomes are commonly used as models for understanding interactions of proteins with membrane lipids; and liposomes have also been used both as carriers for vaccines, and as antigens for induction of antibodies to liposomal lipids. The possibility is proposed that liposomal lipids, or liposome-protein combinations, could be useful as antigens for inducing broadly neutralizing antibodies to HIV-1. C1 Walter Reed Army Inst Res, Dept Vaccine Prod & Delivery, Div Retrovirol, US Mil HIV Res Program, Rockville, MD 20850 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Dept Vaccine Prod & Delivery, Div Retrovirol, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 NR 114 TC 23 Z9 23 U1 0 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0968-7688 J9 MOL MEMBR BIOL JI Mol. Membr. Biol. PD NOV-DEC PY 2006 VL 23 IS 6 BP 453 EP U1 DI 10.1080/09687860600935348 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 108CF UT WOS:000242217200001 PM 17127618 ER PT J AU Klote, MM Agodoa, LY Abbott, KC AF Klote, Mary M. Agodoa, Lawrence Y. Abbott, Kevin C. TI Risk factors for Mycobacterium tuberculosis in US chronic dialysis patients SO NEPHROLOGY DIALYSIS TRANSPLANTATION LA English DT Article DE dialysis; end-stage renal disease; risk factors; tuberculosis ID STAGE RENAL-DISEASE; HEMODIALYSIS; PREVALENCE; INFECTION AB Background. End-stage renal disease is known to disrupt the cell-mediated immune response that is responsible for the killing of intracellular organisms such as Mycobacterium tuberculosis. Risk factors that contribute to the development of tuberculosis (TB) disease in the US dialysis population have not been studied on a large scale. Methods. A retrospective cohort study of TB disease in 272 024 patients in the US Renal Data System initiated on dialysis therapy between 1 April 1995 and 31 December 1999 with Medicare or Medicaid as primary payer were analysed. A total of 21 risk factors were analysed. Results. Among the US population studied, there is a 1.2 and 1.6% cumulative incidence of TB in patients undergoing either peritoneal or haemodialysis, respectively. Ten risk factors for TB that proved to be statistically significant included advanced age (P < 0.001), unemployment (P < 0.001), Medicaid insurance (P < 0.001), reduced body mass index (P < 0.001), decreased serum albumin (P < 0.001), haemodialysis (P = 0.019), both Asian (P = 0.010) and Native American (P = 0.020) race, ischaemic heart disease (P = 0.032), smoking (P = 0.010), illicit drug use (P = 0.018) and anaemia (P = 0.028). TB was independently associated with increased mortality, adjusted hazard ratio (AHR) 1.42 (95% CI 1.18-1.70, P < 0.001). Conclusions. The prevalence of TB disease in the US dialysis population is low compared with worldwide rates; however, the disease is associated with increased mortality. Of the 10 significant risk factors identified, five are potentially modifiable. C1 Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. NIDDK, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Klote, MM (reprint author), Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. EM mary.klote@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 20 TC 14 Z9 15 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0931-0509 J9 NEPHROL DIAL TRANSPL JI Nephrol. Dial. Transplant. PD NOV PY 2006 VL 21 IS 11 BP 3287 EP 3292 DI 10.1093/ndt/gfl488 PG 6 WC Transplantation; Urology & Nephrology SC Transplantation; Urology & Nephrology GA 094ZD UT WOS:000241277100044 PM 16968724 ER PT J AU Weichel, ED Martidis, A Fineman, MS McNamara, JA Park, CH Vander, JF Ho, AC Brown, GC AF Weichel, Eric D. Martidis, Adam Fineman, Mitchell S. McNamara, J. Arch Park, Carl H. Vander, James F. Ho, Allen C. Brown, Gary C. TI Pars plana vitrectomy versus combined pars plana vitrectomy-scleral buckle for primary repair of pseudophakic retinal detachment SO OPHTHALMOLOGY LA English DT Article; Proceedings Paper CT 109th Annual Meeting of the American-Academy-of-Ophthalmology CY OCT 15-18, 2005 CL Chicago, IL SP Amer Acad Ophthalmol ID CYSTOID MACULAR EDEMA; CATARACT-SURGERY; PROLIFERATIVE VITREORETINOPATHY; PNEUMATIC RETINOPEXY; NATIONAL OUTCOMES; INFERIOR BREAKS; VISUAL-ACUITY; FOLLOW-UP; MANAGEMENT; PUCKER AB Purpose: To evaluate pars plana vitrectomy (PPV) versus a combined PPV and scleral buckle (PPV/SB) for repair of noncomplex, pseudophakic retinal detachment. Design: Retrospective, nonrandomized, comparative interventional study. Participants: One hundred fifty-two eyes of 152 patients followed up for a mean of 10 months. The case series included 68 consecutive patients who underwent PPV and 84 consecutive patients who underwent a PPV/SB for primary repair of primary pseudophakic retinal detachment at Wills Eye Hospital between 2002 and 2004. Methods: All primary PPV cases were performed by 2 surgeons who perform primary vitrectomy without regard to location of detachment, number and location of break(s), refractive error, or macula status. All primary PPV/SB were performed by a group of surgeons who solely perform PPV/SB on pseudophakic retinal detachments. All eyes underwent a standard 3-port 20-gauge PPV under wide-field viewing and scleral depression. Endolaser photocoagulation was applied either around the retinal tears or 3600 to the vitreous base region followed by gas tamponade. Patients with proliferative vitreoretinopathy grade C or worse were excluded from the study. Main Outcome Measures: (1) Single surgery anatomic success rates, (2) preoperative and postoperative visual acuity, and (3) complications. Results: The single surgery anatomic success rate in the primary PPV group was 63 of 68 eyes (92.6%; 95% confidence interval [Cl], 84%-98%) and in the primary PPV/SB group was 79 of 84 eyes (94.0%; 95% Cl, 87%-98%). Both groups obtained 100% final reattachment rate. There was no statistically significant difference between the success rates (P = 0.75, Fisher exact test). The PPV group's best-corrected postoperative visual acuity demonstrated a +0.10 logarithm of the minimum angle of resolution improvement over the PPV/SB group (P = 0.07). The PPV group had a smaller incidence of postoperative complications (13/68 patients [19.1%] vs. 27/84 patients [32.1%]; P = 0.10, Fisher exact test). Conclusions: Primary PPV and PPV/SB seem to have similar efficacy in the repair of a matched group of patients with primary noncomplex pseudophakic retinal detachment. There was no statistically significant difference in complication rate between the 2 groups. (c) 2006 by the American Academy of Ophthalmology. C1 Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. Wills Eye Hosp & Res Inst, Retina Serv, Philadelphia, PA USA. Eye Res Inst, Philadelphia, PA USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Dept Ophthalmol, 6900 Georgia Ave, Washington, DC 20307 USA. EM eweichel@hotmail.com NR 56 TC 68 Z9 71 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD NOV PY 2006 VL 113 IS 11 BP 2033 EP 2040 DI 10.1016/j.ophtha.2006.05.038 PG 8 WC Ophthalmology SC Ophthalmology GA 101CS UT WOS:000241717100018 PM 17074564 ER PT J AU Bhuiyan, SMA Alam, MS Sims, SRF AF Bhuiyan, Sharif M. A. Alam, Mohammad S. Sims, S. Richard F. TI Target detection, classification, and tracking using a maximum average correlation height and polynomial distance classification correlation filter combination SO OPTICAL ENGINEERING LA English DT Article DE target detection and classification; MACH filter; PDCCF filter; distortion-invariant target detection; region of interest ID RECOGNITION; MACH AB Simultaneous detection and classification of single/multiple identical and dissimilar targets is very important in automatic target recognition applications. A new approach is proposed for this purpose using a combination of maximum average correlation height (MACH) filter and polynomial distance classifier correlation filter (PDCCF). In this technique, full-resolution MACH filters are applied to the input scene, and the regions of interest (ROIs) containing the probable targets are selected from the input scene based on the ROIs with higher-correlation peak values in the correlation output. Then a multiclass PDCCF is applied to these ROIs to identify target types and reject clutters and/or backgrounds. To increase the robustness of the proposed technique, multiple filters are formulated for multiple ranges of target size and/or orientation variations. The simulation results using real-life imagery indicate the effectiveness of the proposed technique for target detection and classification in the presence of distortion, clutter, and other artifacts. (c) 2006 Society of Photo-Optical Instrumentation Engineers. C1 Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. Univ S Alabama, Dept Elect & Comp Engn, Mobile, AL 36688 USA. USA, RD&E Command, Aviat & Missile RDEC, Redstone Arsenal, AL 35898 USA. RP Bhuiyan, SMA (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. NR 17 TC 11 Z9 11 U1 0 U2 1 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD NOV PY 2006 VL 45 IS 11 AR 116401 DI 10.1117/1.2385631 PG 13 WC Optics SC Optics GA 112LP UT WOS:000242527700032 ER PT J AU Shvidler, J Bertagniolli, R Petermann, GW AF Shvidler, Joseph Bertagniolli, Reono Petermann, Gregory W. TI Useful CT techniques in head and neck imaging SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 109th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation CY SEP 25-28, 2005 CL Los Angeles, CA SP Amer Acad Otolaryngol Head & Neck Surg Fdn C1 Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Shvidler, J (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, MCHK-DSH,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM joseph.shvidler@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD NOV PY 2006 VL 135 IS 5 BP 798 EP 799 DI 10.1016/j.otohns.2006.06.1265 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 103ZP UT WOS:000241926000026 PM 17071315 ER PT J AU Myers, TM Clark, MG AF Myers, Todd M. Clark, Matthew G. TI Serial-probe recognition in rhesus macaques: Effects of midazolam SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article; Proceedings Paper CT Annual Convention of the Southeastern-Association-for-Behavior-Analysis CY NOV, 2002 CL Charleston, SC SP SE Assoc Behav Anal DE visual conditional discrimination; short-term recognition memory; choice latency; sample-stimulus reaction time; benzodiazepine anticonvulsant; midazolam; operant touch screen response; rhesus monkeys ID INTRAMUSCULAR MIDAZOLAM; STATUS EPILEPTICUS; MACACA-MULATTA; INDUCED SEIZURES; AMNESIC ACTION; MONKEYS; DIAZEPAM; PREMEDICATION; DRUGS; TASK AB A serial-probe recognition task was used to assess the effects of midazolam on visual attention and short-term memory in three rhesus monkeys. On each trial, six unique alphanumeric sample stimuli (list items) were presented sequentially followed by a choice period. Choosing the 'probe' stimulus was correct if the probe matched one of the list items; otherwise, choosing the 'default' stimulus (a white square) was correct. Behavior was examined under a range of doses of midazolarn (0.065, 0.13, 0.26, and 0.52 mg/kg IM). Midazolarn did not significantly reduce choice accuracy or change the shape of the serial position function and did not significantly reduce choice responding. However, choice reaction time was significantly increased by the two highest doses of midazolam. Responding directed at the sample stimuli was reduced at the two highest doses of midazolam. Furthermore, 0.52 mg/kg midazolarn significantly increased sample-stimulus reaction time at all six serial positions. Overall, these data suggest that the two highest doses of midazolam tested increase reaction time, but do not directly impair short-term visual recognition memory. This is noteworthy because such doses appear capable of protecting against nerve agent-induced seizures. Published by Elsevier Inc. C1 Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. RP Myers, TM (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM todd.myers2@us.army.mil NR 36 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD NOV PY 2006 VL 85 IS 3 BP 555 EP 561 DI 10.1016/j.pbb.2006.10.009 PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 134ZD UT WOS:000244122500009 PM 17141303 ER PT J AU Bahder, TB Lopata, PA AF Bahder, Thomas B. Lopata, Paul A. TI Fidelity of quantum interferometers SO PHYSICAL REVIEW A LA English DT Article ID PROSPECTS; STATES; NOISE AB For a generic interferometer, the conditional probability density distribution p(phi parallel to m), for the phase phi given measurement outcome m will generally have multiple peaks. Therefore, the phase sensitivity of an interferometer cannot be adequately characterized by the standard deviation, such as Delta phi similar to 1/root N (the standard limit), or Delta phi similar to 1/N (the Heisenberg limit). We propose an alternative measure of phase sensitivity-the fidelity of an interferometer-defined as the Shannon mutual information between the phase shift phi and the measurement outcomes m. As an example application of interferometer fidelity, we consider a generic optical Mach-Zehnder interferometer, used as a sensor of a classical field. For the case where there exists no a priori information on the phase shift, we find the surprising result that maximally entangled state input leads to a lower fidelity than Fock state input, for the same photon number. C1 USA, Aiat & Missile Res Dev & Engn Ctr, Weapons Sci Directorate, Redstone Arsenal, AL 35898 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Bahder, TB (reprint author), USA, Aiat & Missile Res Dev & Engn Ctr, Weapons Sci Directorate, Redstone Arsenal, AL 35898 USA. EM thomas.bahder@us.army.mil NR 31 TC 5 Z9 6 U1 1 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD NOV PY 2006 VL 74 IS 5 AR 051801 DI 10.1103/PhysRevA.74.051801 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 110VH UT WOS:000242408900014 ER PT J AU Shanthakumar, P Balasubramanian, M Pease, DM Frenkel, AI Potrepka, DM Kraizman, V Budnick, JI Hines, WA AF Shanthakumar, P. Balasubramanian, M. Pease, D. M. Frenkel, A. I. Potrepka, D. M. Kraizman, V. Budnick, J. I. Hines, W. A. TI X-ray study of the ferroelectric [Ba0.6Sr0.4] [(YTa)(0.03)Ti-0.94]O-3 SO PHYSICAL REVIEW B LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; ABSORPTION FINE-STRUCTURE; PHASE-TRANSITIONS; DIELECTRIC-PROPERTIES; BARIUM-TITANATE; SOLID-SOLUTION; BATIO3; BEHAVIOR; SRTIO3; FILMS AB We have studied the system [Ba0.6Sr0.4] [(YTa)(0.03)Ti-0.94]O-3, as produced using two different sintering temperatures. It was shown by others that for a sample sintered at 1550 degrees C the material is a relaxor, whereas for the same composition produced with sintering temperature of 1600 degrees C the sample is a normal ferroelectric. We have employed analysis of x-ray diffraction peak broadening, Ti K edge x ray near edge spectroscopy, and extended x-ray absorption edge fine structure spectroscopy of Ta and Y sites in our study. We find that the 1550 degrees C sinter sample has over double the lattice strain as does the 1600 degrees C sample. For the lower temperature sinter material, both Ta and Y go to sites substitutional for Ti in the lattice, with a significant expansion (contraction) of the local perovskite structure about Y (Ta) dopants. Thus, with only three percent B site addition of Y and Ta dopants, there is a strain associated relaxor behavior produced in a bulk sample. For the higher temperature sinter specimen, there is a marked change in the average Y environment relative to the lower temperature sinter sample. C1 Univ Connecticut, Dept Phys, Storrs, CT 06269 USA. Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. Yeshiva Univ, Dept Phys, New York, NY 10016 USA. USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. Rostov State Univ, Rostov Na Donu 344104, Russia. RP Shanthakumar, P (reprint author), Univ Connecticut, Dept Phys, Storrs, CT 06269 USA. RI Frenkel, Anatoly/D-3311-2011; OI Frenkel, Anatoly/0000-0002-5451-1207; Potrepka, Daniel/0000-0002-0528-1038 NR 40 TC 13 Z9 13 U1 0 U2 6 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD NOV PY 2006 VL 74 IS 17 AR 174103 DI 10.1103/PhysRevB.74.174103 PG 10 WC Physics, Condensed Matter SC Physics GA 110VI UT WOS:000242409000041 ER PT J AU Vetter, U Gruber, JB Nijjar, AS Zandi, B Ohl, G Wahl, U De Vries, B Hofsass, H Dietrich, M AF Vetter, Ulrich Gruber, John B. Nijjar, Anmol S. Zandi, Bahram Oehl, Gregor Wahl, Ulrich De Vries, Bart Hofsaess, Hans Dietrich, Marc CA ISOLDE Collaboration TI Crystal field analysis of Pm3+ (4f(4)) and Sm3+ (4f(5)) and lattice location studies of Nd-147 and Pm-147 in w-AlN SO PHYSICAL REVIEW B LA English DT Article ID MOLECULAR-BEAM EPITAXY; IMPLANTED GAN; ENERGY-LEVELS; THIN-FILMS; C-BN; EMISSION; IONS; EU; CATHODOLUMINESCENCE; LUMINESCENCE AB We report a detailed crystal field analysis of Pm3+ and Sm3+ as well as lattice location studies of Pm-147 and Nd-147 in 2H-aluminum nitride (w-AlN). The isotopes of mass 147 were produced by nuclear fission and implanted at an energy of 60 keV. The decay chain of interest in this work is Nd-147 -> Pm-147 -> Sm-147 (stable). Lattice location studies applying the emission channeling technique were carried out using the beta(-) particles and conversion electrons emitted in the radioactive decay of Nd-147 -> Pm-147. The samples were investigated as implanted, and also they were investigated after annealing to temperatures of 873 K as well as 1373 K. The main fraction of about 60% of both Pm-147 as well as Nd-147 atoms was located on substitutional Al sites in the AlN lattice; the remainder of the ions were located randomly within the AlN lattice. Following radioactive decay of Nd-147, the cathodoluminescence spectra of Pm3+ and Sm3+ were obtained between 500 nm and 1050 nm at sample temperatures between 12 K and 300 K. High-resolution emission spectra, representing intra-4f electron transitions, were analyzed to establish the crystal-field splitting of the energy levels of Sm3+ (4f(5)) and Pm3+ (4f(4)) in cationic sites having C-3v symmetry in the AlN lattice. Using crystal-field splitting models, we obtained a rms deviation of 6 cm(-1) between 31 calculated-to-experimental energy (Stark) levels for Sm3+ in AlN. The results are similar to those reported for Sm3+ implanted into GaN. Using a set of crystal-field splitting parameters B-nm, for Pm3+ derived from the present Sm3+ analysis, we calculated the splitting for the F-5(1), I-5(4), and I-5(5) multiplet manifolds in Pm3+ and obtained good agreement between the calculated and the experimental Stark levels. Temperature-dependent lifetime measurements are also reported for the emitting levels F-4(5/2) (Sm3+) and F-5(1) (Pm3+). C1 Univ Texas, Dept Phys & Astron, San Antonio, TX 78249 USA. USA, ARL, Adelphi Lab Ctr, Adelphi, MD 20783 USA. Inst Tecnol & Nucl, P-2686953 Sacavem, Portugal. Katholieke Univ Leuven, Inst Kern Stralingsfys, B-3001 Louvain, Belgium. CERN, Div EP, CH-1211 Geneva 23, Switzerland. Univ Gottingen, Inst Phys 2, D-37073 Gottingen, Germany. RP Vetter, U (reprint author), Univ Marburg, Fachbereich Phys, Renthof 5, D-35032 Marburg, Germany. RI Wahl, Ulrich/J-6134-2013 OI Wahl, Ulrich/0000-0001-7398-2904 NR 37 TC 11 Z9 11 U1 1 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD NOV PY 2006 VL 74 IS 20 AR 205201 DI 10.1103/PhysRevB.74.205201 PG 9 WC Physics, Condensed Matter SC Physics GA 110VM UT WOS:000242409400036 ER PT J AU Harrington, KL Haskvitz, EM AF Harrington, Kendra L. Haskvitz, Esther M. TI Managing a patient's constipation with physical therapy SO PHYSICAL THERAPY LA English DT Article; Proceedings Paper CT Sage-Graduate-School Research Symposium CY APR 23, 2005 CL Albany, NY SP Sage Grad Sch DE constipation; massage; pelvic floor; physical therapy techniques ID CHRONIC IDIOPATHIC CONSTIPATION; QUALITY-OF-LIFE; SLOW-TRANSIT CONSTIPATION; PELVIC FLOOR DYSSYNERGIA; FUNCTIONAL CONSTIPATION; COLONIC FUNCTION; DEFECATION; DEFECOGRAPHY; STIMULATION; BIOFEEDBACK AB Background and Purpose. Constipation is a prevalent condition in the United States, with typical treatment consisting of diet modification, stool softeners, and laxatives. These interventions, however, are not always effective. The purpose of this case report is to describe the use of abdominal massage in physical therapist management for a patient with constipation. Case Description. An 85-year-old woman with constipation was referred for physical therapy following unsuccessful treatment with stool softeners. The patient was instructed in bowel management As well as a daily, 10-minute home abdominal massage program. Outcomes. Upon re-examination, the patient reported a return of normal bowel frequency and function without the need to strain or use digital evacuation. Discussion. Physical therapy incorporating abdominal massage appeared to be helpful in resolving this patient's constipation. Unlike medical management of constipation, no known side effects have been identified with abdominal massage. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. Sage Coll, Dept Phys Therapy, Troy, NY USA. RP Harrington, KL (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. EM kendra.harrington@na.amedd.army.mil NR 43 TC 18 Z9 20 U1 0 U2 2 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD NOV PY 2006 VL 86 IS 11 BP 1511 EP 1519 DI 10.2522/ptj.20050347 PG 9 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 108TB UT WOS:000242261000007 PM 17079751 ER PT J AU Trevino, G Andreas, EL AF Trevino, George Andreas, Edgar L. TI Averaging operators in turbulence SO PHYSICS TODAY LA English DT Letter C1 CHIRES Inc, San Antonio, TX USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Trevino, G (reprint author), CHIRES Inc, San Antonio, TX USA. EM trevinochires@cs.com; eandreas@crrel.usace.army.mil NR 5 TC 2 Z9 2 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD NOV PY 2006 VL 59 IS 11 BP 16 EP 17 PG 2 WC Physics, Multidisciplinary SC Physics GA 102TD UT WOS:000241835300009 ER PT J AU Muehlenbachs, A Mutabingwa, TK Edmonds, S Fried, M Duffy, PE AF Muehlenbachs, Atis Mutabingwa, Theonest K. Edmonds, Sally Fried, Michal Duffy, Patrick E. TI Hypertension and maternal-fetal conflict during placental malaria SO PLOS MEDICINE LA English DT Article ID ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; ANGIOGENIC FACTORS; RISK-FACTORS; PREECLAMPSIA; PREGNANCY; FLT-1; ECLAMPSIA; RECEPTOR; MACROPHAGES AB Background Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory. Methods and Findings In a cross-sectional survey of Tanzanian parturients, the rate of hypertension was similar in placental malaria (PM)-positive (11/85 = 13%) and PM- negative (73/602 = 12%) individuals. However, we found that PM was associated with hypertension in first-time mothers aged 18-20 y but not other mothers. Hypertension was also associated with histologic features of chronic malaria, which is common in first-time mothers. Levels of soluble vascular endothelial growth factor receptor 1 (sVEGFR1), a preeclampsia biomarker, were elevated in first-time mothers with either PM, hypertension, or both, but levels were not elevated in other mothers with these conditions. In first-time mothers with PM, the inflammatory mediator vascular endothelial growth factor (VEGF) was localized to maternal macrophages in the placenta, while sVEGFR1, its soluble inhibitor, was localized to the fetal trophoblast. Conclusions The data suggest that maternal-fetal conflict involving the VEGF pathway occurs during PM, and that sVEGFR1 may be involved in the relationship between chronic PM and hypertension in first-time mothers. Because placental inflammation causes poor fetal outcomes, we hypothesize that fetal mechanisms that promote sVEGFR1 expression may be under selective pressure during first pregnancies in malaria-endemic areas. C1 Seattle Biomed Res Inst, MOMS Project, Seattle, WA 98109 USA. Univ Washington, Seattle, WA 98195 USA. London Sch Hyg & Trop Med, London WC1, England. Natl Inst Med Res, Dar Es Salaam, Tanzania. Muheza Designated Dist Hosp, Muheza, Tanzania. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, MOMS Project, 4 Nickerson St, Seattle, WA 98109 USA. EM pduffy@sbri.org FU NHLBI NIH HHS [T32HL07312, T32 HL007312]; NIAID NIH HHS [R01AI52059, R01 AI052059] NR 41 TC 55 Z9 56 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD NOV PY 2006 VL 3 IS 11 BP 2124 EP 2130 AR e446 DI 10.1371/journal.pmed.0030446 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 110JO UT WOS:000242374800017 PM 17105340 ER PT J AU O'Connor, SD Summers, RM Yao, JH Pickhardt, PJ Choi, JR AF O'Connor, Stacy D. Summers, Ronald M. Yao, Jianhua Pickhardt, Perry J. Choi, J. Richard TI CT Colonography with computer-aided polyp detection: Volume and attenuation thresholds to reduce false-positive findings owing to the ileocecal valve SO RADIOLOGY LA English DT Article ID TOMOGRAPHIC VIRTUAL COLONOSCOPY; COLONIC POLYPS; SCREENING MAMMOGRAPHY; LUNG NODULES; DIAGNOSIS; LESIONS; FEASIBILITY; POPULATION; PITFALLS; FEATURES AB Purpose: To retrospectively identify volume and average attenuation thresholds for differentiating between ileocecal valve (ICV) and polyp at computed tomographic (CT) colonography with computer-aided detection (CAD). Materials and Methods: Informed consent (with consent for future retrospective research) and institutional review board (IRB) approval were obtained for the original prospective study. This retrospective study had IRB approval, as well, and was HIPAA-compliant. A total of 496 patients were selected from a larger screening population. CT colonographic images from 394 patients (227 men, 167 women; mean age, 58.0 years; range, 40-79 years) were used as a training set, and images from 102 patients (76 men, 26 women; mean age, 59.8 years; range, 46-79 years) were used as a test set. A series of 2742 volume and attenuation thresholds, for which segmented findings both larger in volume and lower in average attenuation were labeled as ICVs and remaining findings were labeled polyps, were applied to the training set to determine settings with 100% sensitivity for polyp detection and the highest specificity for ICV detection. The optimal settings were then applied to the test set. Significance was assessed with the Fisher exact test, and 95% confidence intervals (CIs) were computed for sensitivity and specificity. Results: A total of 386 ICVs and 67 adenomatous polyps from the training set and 102 ICVs and 138 adenomatous polyps from the test set could be segmented with a three-dimensional segmentation algorithm. When supine and prone images were counted individually, 746 nonunique ICVs from the training set and 191 from the test set were segmentable. In the training set, a volume of 600 mm(3) and an attenuation of 36 HU provided 100% sensitivity (67 polyps; 95% CI: 93%, 100%) and the optimal 83% specificity (618 of 746 ICVs; 95% CI: 80%, 85%). When applied to the test set, this combination provided 97% sensitivity (134 of 138 polyps; 95% CI: 92%, 99%) and 84% specificity (160 of 191 ICVs; 95% CI: 78%, 89%). Differences in sensitivity and specificity in the detection of polyps between the sets were not significant. Conclusion: Volume and average CT attenuation thresholds can help differentiate most ICVs from true polyps. C1 NIH, Dept Radiol, Bethesda, MD 20892 USA. Natl Naval Med Ctr, Bethesda, MD USA. Univ Wisconsin, Sch Med, Dept Radiol, Madison, WI USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Summers, RM (reprint author), NIH, Dept Radiol, 10 Ctr Dr,Bldg 10,Rm 1C351,MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS NR 38 TC 15 Z9 15 U1 0 U2 1 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD NOV PY 2006 VL 241 IS 2 BP 426 EP 432 DI 10.1148/radiol.2412051223 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 098KM UT WOS:000241519400013 PM 17005773 ER PT J AU Smith, R AF Smith, Roger TI Modeling R&D investments SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Article DE R&D investment; competitive intelligence; financial modeling ID DEVELOPMENT LEADERBOARD; DEVELOPMENT EXPENDITURES AB Financial data from 91 of the top 100 U.S. companies that invested in R&D during 2004 and 2003 were examined, including the relationship between these companies' sales, profits, growth rates, capital investments, and number of employees. This resulted in two linear equations that provide a high degree of correlation with the data and can be used to estimate R&D investment levels for companies about which that is unknown. The first of these calculates current-year R&D based on previous-year R&D, company size, and capital expenditures. The second, much simpler model, predicts current-year R&D from previous-year R&D. This simpler model may be driven by the relatively static financial years 2002-2004 from which data were analyzed. C1 USA, Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), USA, Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 14 TC 5 Z9 5 U1 0 U2 5 PU INDUSTRIAL RESEARCH INSTITUTE, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD NOV-DEC PY 2006 VL 49 IS 6 BP 16 EP 22 PG 7 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 102LP UT WOS:000241812900007 ER PT J AU Abdel-Malek, K Mi, Z Yang, JZ Nebel, K AF Abdel-Malek, Karim Mi, Zan Yang, Jingzhou Nebel, Kyle TI Optimization-based trajectory planning of the human upper body SO ROBOTICA LA English DT Article DE planning trajectory; biomechanics; minimum jerk; B-splines; Cartesian space; joint space; direct optimization-based method ID RAPID HUMAN MOVEMENTS; KINEMATIC THEORY; ARM MOVEMENTS; MULTIOBJECTIVE OPTIMIZATION; PAYLOAD CONSTRAINTS; PATH; MANIPULATORS; MODEL; SPACE; TIME AB This paper presents studies of the coordination of human upper body voluntary movement. A minimum-jerk 3D model is used to obtain the desired path in Cartesian space, which is widely used in the prediction of human reach movement. Instead of inverse kinematics, a direct optimization approach is used to predict each joint's profile (a spline curve). This optimization problem has four cost function terms: (1) Joint displacement function that evaluates displacement of each joint away from its neutral position; (2) Inconsistency function, which is the joint rate change (first derivative) and predicted overall trend from the initial target point to the final target point; (3) The non-smoothness function of the trajectory, which is the second derivative of the joint trajectory; (4) The non-continuity function, which consists of the amplitudes of joint angle rates at the initial and final target points, in order to emphasize smooth starting and ending conditions. This direct optimization technique can be used for potentially any number of degrees of freedom (DOF) system and it reduces the cost associated with certain inverse kinematics approaches for resolving joint profiles. This paper presents a high redundant upper-body modeling with 15 DOFs. Illustrative examples are presented and an interface is set up to visualize the results. C1 Univ Iowa, Ctr Comp Aided Design, Virtual Soldier Res Program, Iowa City, IA 52242 USA. USA, TACOM, RDECOM, AMSRD,TAR NAC, Warren, MI 48397 USA. RP Abdel-Malek, K (reprint author), Univ Iowa, Ctr Comp Aided Design, Virtual Soldier Res Program, 111 Engn Res Facil, Iowa City, IA 52242 USA. EM amalek@engineering.uiowa.edu; jyang@engineering.uiowa.edu RI Yang, James/G-9801-2012 NR 45 TC 24 Z9 26 U1 0 U2 7 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0263-5747 EI 1469-8668 J9 ROBOTICA JI Robotica PD NOV-DEC PY 2006 VL 24 BP 683 EP 696 DI 10.1017/S0263574706002852 PN 6 PG 14 WC Robotics SC Robotics GA 110ON UT WOS:000242388300003 ER PT J AU Sharp, MK Adalier, K AF Sharp, M. K. Adalier, K. TI Seismic response of earth dam with varying depth of liquefiable foundation layer SO SOIL DYNAMICS AND EARTHQUAKE ENGINEERING LA English DT Article DE earth dam; centrifuge; physical modeling; numerical modeling; liquefaction; earthquakes ID LIQUEFACTION RESISTANCE AB Earthquake induced liquefaction continues to be a major threat to many engineered structures around the world. Analysis of liquefaction becomes particularly difficult for two-dimensional (and 3D) problems such as dam/foundation systems. Predominantly, analyses for such systems are performed utilizing some type of finite element or finite difference procedure. Verification or validation of the analyses relies on very limited field performance data with reduced knowledge of the full scope of system conditions or loading conditions. Research reported in this paper represents a portion of ongoing work to obtain a database of information useful for numerical model calibration and to gain a better understanding of the complex dynamics of liquefying foundations under earth dams. Specifically, a highly instrumented model of an earth dam with clay core founded on a liquefiable foundation subjected to earthquake loading is being studied. Properties of the liquefiable foundation are varied to determine the related effects on the overlying earth dam. In this paper, results from three centrifuge physical models will be presented. The models are identical, with the exception of the location (depth) of a liquefiable layer in the foundation, and are subjected to the same dynamic excitation. Results and discussion related to the significance of the liquefiable layer location within the foundation and damage to the earth dam are presented. Published by Elsevier Ltd. C1 Centrifuge Res Ctr, Engn Res & Dev Ctr, Vicksburg, MS USA. Florida State Univ, Dept Civil & Environm Engn, Panama City, FL USA. RP Sharp, MK (reprint author), Centrifuge Res Ctr, Engn Res & Dev Ctr, Vicksburg, MS USA. EM Michael.K.Sharp@erdc.usace.army.mil NR 18 TC 7 Z9 8 U1 1 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0267-7261 J9 SOIL DYN EARTHQ ENG JI Soil Dyn. Earthq. Eng. PD NOV PY 2006 VL 26 IS 11 BP 1028 EP 1037 DI 10.1016/j.soildyn.2006.02.007 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 094JO UT WOS:000241235900005 ER PT J AU Wintz, H Yoo, LJ Loguinov, A Wu, YY Steevens, JA Holland, RD Beger, RD Perkins, EJ Hughes, O Vulpe, CD AF Wintz, Henri Yoo, Leslie J. Loguinov, Alex Wu, Ying-Ying Steevens, Jeffrey A. Holland, Ricky D. Beger, Richard D. Perkins, Edward J. Hughes, Owen Vulpe, Chris D. TI Gene expression profiles in fathead minnow exposed to 2,4-DNT: Correlation with toxicity in mammals SO TOXICOLOGICAL SCIENCES LA English DT Article DE dinitrotoluene; peroxisome proliferators; methemoglobinemia; microarrays; ecotoxicogenomics ID PROLIFERATOR-ACTIVATED-RECEPTOR; MITOCHONDRIAL TRANSCRIPTION FACTOR; COA OXIDASE ACTIVITY; PEROXISOME PROLIFERATORS; PIMEPHALES-PROMELAS; POOLING SAMPLES; ALPHA; MICROARRAYS; NERVE; ECOTOXICOLOGY AB Toxicogenomics, the genome-wide analysis of gene expression to study the effect of toxicants, has great potential for use in environmental toxicology. Applied to standard test organisms, it has possible applications in aquatic toxicology as a sensitive monitoring tool to detect the presence of contaminants while providing information on the mechanisms of action of these pollutants. We describe the use of a complementary DNA (cDNA) microarray of the fathead minnow (Pimephales promelas) a standard sentinel organism in aquatic toxicology, to better understand the mechanisms of toxicity of 2,4-dinitrotoluene (2,4-DNT) which is released in the environment through military and industrial use. We have constructed a fathead minnow microarray containing 5000 randomly picked anonymous cDNAs from a whole fish cDNA library. Expression profiles were analyzed in fish exposed to 2,4-DNT for 10 days at three concentrations (11, 22, and 44 mu M, respectively) below the measured median lethal concentration (58 mu M). Sequence analysis of cDNAs corresponding to differentially expressed genes affected by exposure revealed that lipid metabolism and oxygen transport genes were prominently affected in a dose-specific manner. We measured liver lipids and demonstrate that lipid metabolism is indeed perturbed following exposure. These observations correlate well with available toxicological data on 2,4-DNT. We present possible modes of action of 2,4-DNT toxicity and suggest that fathead minnow cDNA microarrays can be useful to identify mechanisms of toxicity in fish and as a predictive tool for toxicity in mammals. C1 Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA. Univ Calif Berkeley, Berkeley Inst Environm, Berkeley, CA 94720 USA. USA, Corps Engineer, Ctr Res & Dev, Environm Lab, Vicksburg, MS 39180 USA. Natl Ctr Toxicol Res, Div Syst Toxicol, Jefferson, AR 72079 USA. Eon Corp, Davis, CA 95616 USA. RP Wintz, H (reprint author), Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Morgan Hall, Berkeley, CA 94720 USA. EM wintz@berkeley.edu NR 53 TC 38 Z9 39 U1 1 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2006 VL 94 IS 1 BP 71 EP 82 DI 10.1093/toxsci/kfl080 PG 12 WC Toxicology SC Toxicology GA 092KL UT WOS:000241095300008 PM 16917068 ER PT J AU Arzola, J Baughman, SM Hernandez, J Bishoff, JT AF Arzola, Jorge Baughman, Steven M. Hernandez, Javier Bishoff, Jay T. TI Computed tomography-guided, resistance-based, percutaneous radiofrequency ablation of renal malignancies under conscious sedation at two years of follow-up SO UROLOGY LA English DT Article ID RADIO-FREQUENCY ABLATION; INITIAL-EXPERIENCE; CELL CARCINOMA; TUMORS; SUCCESS AB Objectives. To evaluate the use of computed tomography-guided, resistance-based, percutaneous radio-frequency ablation of renal malignancies using conscious sedation. Methods. Twenty-three patients with a mean age of 74 years underwent 27 PRFA treatments, using only conscious sedation, for enhancing renal masses, with a mean renal mass of 2.69 cm. All patients had multiple medical comorbidities that precluded standard operative management. Patients were followed up postoperatively at 3-month intervals with renal function studies and enhanced imaging.. Successful ablation was defined as a lack of enhancement or resolution of the renal mass. Results. Of the 23 patients, 16 (80%) had successful ablation with a single treatment, 4 had initial failure, and 3 were lost to follow-up. Of the 4 patients with initial failure, 2 underwent reablation successfully, 1 patient elected watchful waiting, and 1 patient died of metastatic renal cell carcinoma. The overall cancer-free survival rate was 90% (18 of 20 patients) at a mean follow-up of 24 months. The exclusion of 2 patients who underwent four sessions for renal masses greater than 4 cm improved the survival rate to 94% (17 of 18). No statistically significant difference was found between the preoperative and postoperative serum creatinine levels (P = 0.46), even in the patients with a preoperative creatinine level greater than 1.5 (P = 0.51). Our only complication was a single perinephric hematoma that resolved spontaneously. Conclusions. We have demonstrated promising oncologic results for computed tomography-guided percutaneous radio-frequency ablation of tumors in select patients with small renal masses. The procedure was well tolerated under conscious sedation. None of the patients demonstrated significant changes in renal function. C1 USAF, MC, FS, Dept Urol,Wilford Hall Med Ctr,Lackland AFB, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Urol Oncol, San Antonio, TX USA. RP Arzola, J (reprint author), USAF, MC, FS, Dept Urol,Wilford Hall Med Ctr,Lackland AFB, San Antonio, TX 78236 USA. EM jorge.arzola@lackland.af.mil NR 18 TC 30 Z9 30 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD NOV PY 2006 VL 68 IS 5 BP 983 EP 987 DI 10.1016/j.urology.2006.06.014 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 113IV UT WOS:000242592500014 PM 17095059 ER PT J AU Arzola, J Hutton, RL Baughman, SM Mora, RV AF Arzola, Jorge Hutton, Robert L. Baughman, Steven M. Mora, Rafael V. TI Adult-type testicular granulosa cell tumor: Case report and review of the literature SO UROLOGY LA English DT Review ID STROMAL TUMOR; TESTIS; NEOPLASMS AB We report the clinical, sonographic, and pathologic findings of an incidentally discovered testicular granulosa cell tumor of the adult type in a 32-year-old man. Serum tumor markers were within normal limits. The sonographic findings revealed a well-circumscribed, hypoechoic mass. Gross inspection confirmed a unilobular, well-circumscribed mass without necrosis. Microscopically, the mass was demarcated by a thin capsule, with tumor cells arranged in nests with low mitotic activity. These cells were diffusely immunoreactive for vimentin and focally for inhibin. The entrapped rete epithelium stained positive for pancytokeratin (L mu-5). We present our management of this rare malignancy. C1 Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Urol, Ft Sam Houston, TX 78234 USA. RP Hutton, RL (reprint author), Brooke Army Med Ctr, Dept Pathol & Lab Serv, Attn MCHE-PLA,3856 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM robert.hutton@amedd.army.mil NR 13 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD NOV PY 2006 VL 68 IS 5 AR 1121.e13 DI 10.1016/j.urology.2006.06.029 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 113IV UT WOS:000242592500051 ER PT J AU Tan, YQ Davidson, GR See, CH Dunbar, DC O'Haver, JH Rice, S Harrelson, DW Zakikhani, M AF Tan, Yongqiang Davidson, Gregg R. See, Chun Hwa Dunbar, D. Chuck O'Haver, John H. Rice, Stephanie Harrelson, Danny W. Zakikhani, Mansour TI Picric acid degradation in sediments from the Louisiana Army Ammunition Plant SO WATER AIR AND SOIL POLLUTION LA English DT Article DE 2,4,6-trinitrophenol; degradation; LAAP; natural attenuation; picric acid ID RHODOCOCCUS-ERYTHROPOLIS; SOIL; BIODEGRADATION; MANGANESE; TIO2 AB Picric acid is an explosive historically produced and disposed at the Louisiana Army Ammunition Plant (LAAP) in northern Louisiana. The potential for natural degradation of picric acid was investigated by creating picric-acid slurries with four LAAP sediments of variable composition and monitoring for up to 98 days. The concentrations of picric acid decreased rapidly in all slurries during the first day, attributed to adsorption, followed by slower decreases in some samples due to degradation. Degradation in unsterilized slurries was nearly complete within 80 days for two of the four sediments. Increases in nitrite and nitrate concentration over time were proportional to the loss of picric acid and indicate that at least two of the three nitrite groups were removed from the picric acid molecule. The absence of significant concentrations of compounds with a mass greater than 100 amu in the final solutions suggests that all three nitrite groups were removed. No correlation was found between the degree of degradation and grain size, clay content, organic content, carbonate content, or a suite of element concentrations in the sediment. Degradation in sterilized samples was minimal for all sediment slurries, indicating microbial activity as the primary mechanism of degradation. C1 Mississippi State Univ, Dept Geol & Geol Engn, Mississippi State, MS 39762 USA. Mississippi State Univ, Dept Chem Engn, Mississippi State, MS 39762 USA. Mississippi State Univ, Natl Ctr Nat Prod Res, Mississippi State, MS 39762 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Davidson, GR (reprint author), Mississippi State Univ, Dept Geol & Geol Engn, Mississippi State, MS 39762 USA. EM davidson@olemiss.edu NR 29 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD NOV PY 2006 VL 177 IS 1-4 BP 169 EP 181 DI 10.1007/s11270-006-9133-y PG 13 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 113WI UT WOS:000242628300011 ER PT J AU Kiang, JG Tsen, KT AF Kiang, Juliann G. Tsen, K. T. TI Biology of hypoxia SO CHINESE JOURNAL OF PHYSIOLOGY LA English DT Review DE hypoxia; iNOS; caspase; ATP; calcium; NO; free radical ID NITRIC-OXIDE SYNTHASE; APOPTOSIS-INDUCING FACTOR; NEURONAL CELL-DEATH; HEMORRHAGE-INDUCED INCREASES; EPIDERMOID A-431 CELLS; HEAT-SHOCK PROTEINS; RABBIT CAROTID-BODY; CYTOSOLIC FREE CA2+; CASPASE ACTIVATION; ADENOSINE-TRIPHOSPHATE AB Hypoxia is an often seen problem resulting from conditions such as ischemia, hemorrhage, stroke, premature birth, and other cardiovascular difficulties. To find useful remedies that are capable of ameliorating its casualty is an essential effort. Although the underlying mechanisms of the hypoxia-induce injury and cell death are still not fully understood, it has been shown that hypoxia induces nitric oxide (NO) overproduction and inducible nitric oxide synthase (iNOS) overexpression that play important roles in producing injury including increases in polymorphonuclear neutrophils (PMN) infiltration to injured tissues and leukotriene B-4 (LTB4) generation. Moreover, it has been evident that transcription factors responsible for iNOS expression are also altered by hypoxia. Hypoxia also increases intracellular Ca2+ concentration, tumor necrosis factor-a, lipid peroxidation, prostaglandin E, production, activity of caspase-3 and -9, and release of cytochrome c from mitochondria, apoptosis inducible factor, and endonuclease G. However, it has been shown that downregulation of iNOS can limit cell injury caused by hypoxia. In our laboratory, we have found that treatment with either iNOS inhibitors or iNOS siRNA inhibits iNOS expression, reduces lipid peroxidation, apoptosome formation, and cellular caspase-3 activity, preserves cellular ATP levels, and increases cell survival. Therefore, iNOS inhibition may be a novel mechanism for protection from hypoxia-induced injury and cell death. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. RP Kiang, JG (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. EM Juliann.Kiang@na.amedd.army.mil; kiangj@comcast.net NR 106 TC 49 Z9 54 U1 0 U2 5 PU CHINESE PHYSIOLOGICAL SOC PI TAIPEI PA NATL YANG-MING UNIV, TAIPEI, TAIWAN SN 0304-4920 J9 CHINESE J PHYSIOL JI Chin. J. Physiol. PD OCT 31 PY 2006 VL 49 IS 5 BP 223 EP 233 PG 11 WC Physiology SC Physiology GA 100SX UT WOS:000241690100002 PM 17294830 ER PT J AU Malik, G Gorvanov, N Das, S Gurusamy, N Otani, H Maulik, N Goswami, S Das, DK AF Malik, Gautarn Gorvanov, Nikolai Das, Samarjit Gurusamy, Narasimman Otani, Hajime Maulik, Nilanjana Goswami, Shyamal Das, Dipak K. TI Ischernic preconditioning triggers nuclear translocation of thioredoxin and its interaction with REF-1 potentiating a survival signal through PI-3-KINASE-AKT pathway SO CIRCULATION LA English DT Meeting Abstract CT 79th Annual Scientific Session of the American-Heart-Association CY NOV 12-15, 2006 CL Chicago, IL SP Amer Heart Assoc C1 Univ Connecticut, Sch Med, Farmington, CT USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. Kansai Med Univ, Moriguchi, Osaka 570, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 31 PY 2006 VL 114 IS 18 SU S BP 296 EP 296 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 102EC UT WOS:000241792802036 ER PT J AU Taylor, AJ Bindeman, J Le, T Bauer, K Byrd, C Feuerstein, I Lee, JK Grace, KA O'Malley, PG AF Taylor, Allen J. Bindeman, Jody Le, Toan Bauer, Kelly Byrd, Carole Feuerstein, Irwin Lee, Jeannie K. Grace, Karen A. O'Malley, Patrick G. TI Does screening for coronary calcium "change management"? Statin and aspirin use over 6-years in the PACC project SO CIRCULATION LA English DT Meeting Abstract CT 79th Annual Scientific Session of the American-Heart-Association CY NOV 12-15, 2006 CL Chicago, IL SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 31 PY 2006 VL 114 IS 18 SU S BP 823 EP 823 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 102EC UT WOS:000241792805317 ER PT J AU Convertino, VA Ryan, KL Rickards, CA Cooke, WH Idris, AH Metzger, AK Holcomb, JB Adams, BD Lurie, KG AF Convertino, Victor A. Ryan, Kathy L. Rickards, Caroline A. Cooke, William H. Idris, Ahamed H. Metzger, Anja K. Holcomb, John B. Adams, Bruce D. Lurie, Keith G. TI Inspiratory resistance maintains arterial pressure during central hypovolemia: Implications for treatment of patients with severe hemorrhage. SO CIRCULATION LA English DT Meeting Abstract CT 79th Annual Scientific Session of the American-Heart-Association CY NOV 12-15, 2006 CL Chicago, IL SP Amer Heart Assoc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas San Antonio, San Antonio, TX 78285 USA. Univ Southampton, Med Ctr, Dallas, TX USA. Adv Circulat Syst Inc, Eden Prairie, MN USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Univ Minnesota, Ctr Hlth, Minneapolis, MN 55455 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD OCT 31 PY 2006 VL 114 IS 18 SU S BP 1200 EP 1200 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 102EC UT WOS:000241792805736 ER PT J AU Crenshaw, ME AF Crenshaw, Michael E. TI The quantized field in a dielectric and application to the radiative decay of an embedded atom SO PHYSICS LETTERS A LA English DT Article DE macroscopic quantization; local-field; spontaneous emission ID SPONTANEOUS EMISSION; QUANTUM OPTICS; MEDIA AB Weisskopf-Wigner theory applied to the macroscopically quantized field shows that the spontaneous emission rate of an excited atom is unaffected by a dielectric, rather than enhanced by a factor of the refractive index, as local-field effects are eliminated in the continuum approximation. Dielectric effects on an atom must be calculated microscopically. Published by Elsevier B.V. C1 USA, AMSRD AMR WS ST, RDECOM, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, AMSRD AMR WS ST, RDECOM, Redstone Arsenal, AL 35898 USA. EM michael.crenshaw@us.army.mil NR 25 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD OCT 30 PY 2006 VL 358 IS 5-6 BP 438 EP 442 DI 10.1016/j.physleta.2006.05.049 PG 5 WC Physics, Multidisciplinary SC Physics GA 100AZ UT WOS:000241640800022 ER PT J AU Stewart, VA McGrath, SM Walsh, DS Davis, S Hess, AS Ware, LA Kester, KE Cummings, JF Burge, JR Voss, G Delchambre, M Garcon, N Tang, DB Cohen, JD Heppner, DG AF Stewart, V. Ann McGrath, Shannon M. Walsh, Douglas S. Davis, Stacey Hess, Aaron S. Ware, Lisa A. Kester, Kent E. Cummings, James F. Burge, J. Robert Voss, Gerald Delchambre, Martine Garcon, Nathalie Tang, Douglas B. Cohen, Joe D. Heppner, D. Gray, Jr. TI Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A SO VACCINE LA English DT Article DE malaria; vaccine; RTS,S; adjuvant; ELISpot; cell-mediated immunogenicity ID PLASMODIUM-FALCIPARUM INFECTION; CIRCUMSPOROZOITE PROTEIN VACCINE; RANDOMIZED CONTROLLED-TRIAL; IMMUNE-RESPONSES; FOLLOW-UP; EFFICACY; IMMUNIZATION; PRIMATES; CHILDREN; DISEASE AB Background: RTS,S/AS02A, a pre-erythrocytic Plasmodiumfalciparum vaccine based upon the circumsporozoite protein, is the only vaccine demonstrated in field trials to confer partial protection against a range of malaria disease manifestations. Pre-clinical studies are on-going to identify new RTS,S formulations with improved magnitude and duration of specific immunity. Methods: Rhesus macaques were immunized with saline or one of four "RTS,S/adjuvant" formulations at 0, 4, and 12 weeks: RTS,S/ASOIB, RTS, S/AS02A-standard (current formulation), RTS,S/AS05 or RTS,S/AS06. An RTS,S/AS02A-accelerated group was immunized at 0, 1, and 4 weeks. Outcomes were safety, RTS,S-specific antibody, and IFN-gamma and IL-5 ELISpots (weeks 14 and 34). Findings: All regimens were safe and, except for RTS,S/AS06, generated equivalent high titer antibody levels. For IFN-gamma ELISpots, RTS,S/AS01B had the highest geometric mean (GM) values at weeks 14 and 34, and was the only group with an overall GM mean (weeks 14 + 34) higher than RTS,S/AS02A-standard (p < 0.015). For IFN-gamma to IL-5 ELISpot response ratios, RTS,S/AS01B had the highest values at weeks 14 and 34, and was the only group higher than RTS,S/AS02A-standard at each individual time point and overall (weeks 14 + 34) (p < 0.015). Interpretation: RTS,S/AS01B is a safe and immunogenically superior formulation for cellular responses, in comparison with the RTS, S/AS02A-standard. Phase 1, 2a, and 2b clinical trials are underway to determine if RTS,S/AS0113 demonstrates improved immunogenicity and protective efficacy against experimental challenge and natural mosquito-borne malaria. Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Biometr, Silver Spring, MD 20910 USA. GlaxoSmithKline Inc, Rixensart, Belgium. RP Stewart, VA (reprint author), Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. EM ann.stewart@na.amedd.army.mil RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 34 TC 65 Z9 67 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 30 PY 2006 VL 24 IS 42-43 BP 6483 EP 6492 DI 10.1016/j.vaccine.2006.06.033 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 102XL UT WOS:000241846700005 PM 16904798 ER PT J AU Stewart, VA Walsh, DS McGrath, SM Kester, KE Cummings, JF Voss, G Delchambre, M Garcon, N Cohen, JD Heppner, DG AF Stewart, V. Ann Walsh, Douglas S. McGrath, Shannon M. Kester, Kent E. Cummings, James F. Voss, Gerald Delchambre, Martine Garcon, Nathalie Cohen, Joe D. Heppner, D. Gray, Jr. TI Cutaneous delayed-type hypersensitivity (DTH) in a multi-formulation comparator trial of the anti-falciparum malaria vaccine candidate RTS,S in rhesus macaques SO VACCINE LA English DT Article; Proceedings Paper CT 4th Meeting on Novel Adjuvabt In/Close Human Clinical Testing CY JUN 23-25, 2003 CL Annecy, FRANCE SP World Hlth Org DE malaria; vaccine; RTS,S; adjuvant; delayed-type hypersensitivity (DTH); cell-mediated inummogenicity ID CIRCUMSPOROZOITE PROTEIN VACCINE; SEMI-IMMUNE ADULTS; PLASMODIUM-FALCIPARUM; IMMUNOGENICITY TRIAL; NONHUMAN-PRIMATES; RESPONSES; EFFICACY; GAMBIA; SAFETY; TRANSMISSION AB Background: Studies are underway to identify more immunogenic formulations of the existing anti-falciparum malaria vaccine RTS,S/AS02A. To supplement in vitro immunogenicity assays, cutaneous delayed-type hypersensitivity (DTH) may be a useful indicator of functional, cellmediated immunogenicity. Methods: Adult rhesus monkeys were immunized with saline or one of four RTS,S/adjuvant formulations: RTS,S/AS01B, RTS,S/AS02A-standard (current formulation), RTS,S/AS05 or RTS,S/AS06 at 0, 4, and 12 weeks. An additional cohort received RTS,S/AS02A-accelerated, at 0, 1, and 4 weeks. Six months after completing immunizations, five vaccine-relevant antigens (high and low doses) and two controls were administered intradermally. DTH reactivity (induration) was measured at 48 and 72 h, and selected sites were biopsied for histological confirmation. Results: In comparison with RTS,S/AS02A-standard, RTS,S/AS01B and RTS,S/AS05 each had larger mean reactions (induration) at 5 of 10 (p < 0.01, at each site) and 1 of 10 (p < 0.05, at the single site) vaccine relevant test sites, respectively. Histologically, perivascular mononuclear cell infiltrates, a cardinal feature of DTH, were largest in the RTS,S/AS01B monkeys. Interpretation: In DTH testing, with histological confirmation, RTS,S/AS01B was immunogenically superior to RTS,S/AS02A-standard and two other novel RTS,S formulations. The DTH outcomes paralleled conventional in vitro cellular immunogenicity assessments in distinguishing among similar RTS,S formulations, even at 6 months after final vaccination. Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD 20910 USA. GlaxoSmithKline Inc, Biol, Rixensart, Belgium. RP Stewart, VA (reprint author), Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. EM ann.stewart@na.amedd.army.mil RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 35 TC 20 Z9 21 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 30 PY 2006 VL 24 IS 42-43 BP 6493 EP 6502 DI 10.1016/j.vaccine.2006.06.035 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 102XL UT WOS:000241846700006 PM 16911849 ER PT J AU Lisal, M Brennan, JK Smith, WR AF Lisal, Martin Brennan, John K. Smith, William R. TI Mesoscale simulation of polymer reaction equilibrium: Combining dissipative particle dynamics with reaction ensemble Monte Carlo. I. Polydispersed polymer systems SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID GRAND-CANONICAL ENSEMBLE; CHEMICAL-REACTION EQUILIBRIA; MOLECULAR-DYNAMICS; COMPUTER-SIMULATION; PHASE-EQUILIBRIA; THERMODYNAMIC PROPERTIES; CARBON MICROPORES; CONFINEMENT; TEMPERATURE; PLASMAS AB We present a mesoscale simulation technique, called the reaction ensemble dissipative particle dynamics (RxDPD) method, for studying reaction equilibrium of polymer systems. The RxDPD method combines elements of dissipative particle dynamics (DPD) and reaction ensemble Monte Carlo (RxMC), allowing for the determination of both static and dynamical properties of a polymer system. The RxDPD method is demonstrated by considering several simple polydispersed homopolymer systems. RxDPD can be used to predict the polydispersity due to various effects, including solvents, additives, temperature, pressure, shear, and confinement. Extensions of the method to other polymer systems are straightforward, including grafted, cross-linked polymers, and block copolymers. To simulate polydispersity, the system contains full polymer chains and a single fractional polymer chain, i.e., a polymer chain with a single fractional DPD particle. The fractional particle is coupled to the system via a coupling parameter that varies between zero (no interaction between the fractional particle and the other particles in the system) and one (full interaction between the fractional particle and the other particles in the system). The time evolution of the system is governed by the DPD equations of motion, accompanied by changes in the coupling parameter. The coupling-parameter changes are either accepted with a probability derived from the grand canonical partition function or governed by an equation of motion derived from the extended Lagrangian. The coupling-parameter changes mimic forward and reverse reaction steps, as in RxMC simulations. (c) 2006 American Institute of Physics. C1 Acad Sci Czech Republ, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague 6, Czech Republic. JE Purkinje Univ, Dept Phys, Fac Sci, Usti Nad Labem 40096, Czech Republic. USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Univ Ontario, Fac Sci, Inst Technol, Oshawa, ON L1H 7K4, Canada. RP Lisal, M (reprint author), Acad Sci Czech Republ, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague 6, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Smith, William/G-4404-2010 OI Lisal, Martin/0000-0001-8005-7143; Smith, William/0000-0002-1982-2050 NR 58 TC 21 Z9 21 U1 1 U2 22 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD OCT 28 PY 2006 VL 125 IS 16 AR 164905 DI 10.1063/1.2359441 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 101EP UT WOS:000241722000083 PM 17092137 ER PT J AU Jiang, RZ Chu, D AF Jiang, Rongzhong Chu, Deryn TI Power management of a direct methanol fuel cell system SO JOURNAL OF POWER SOURCES LA English DT Article DE DMFC; power management; methanol crossover; fuel efficiency; fuel cell ID PERFORMANCE; ELECTROLYTE; MEMBRANES; CROSSOVER; ELECTROREDUCTION; TRANSPORT; DMFC AB The effect of discharge rate of direct methanol fuel cell (DMFC) on fuel efficiency was comparatively investigated using a DMFC single cell and a DMFC system. The results obtained from the single cell were used to model the DMFC system. Several semi-empirical equations were derived that relate discharge current, voltage, power output, energy density and fuel consumption for a nominal 25 W DMFC system. The decrease in fuel efficiency with decreased power output that is observed for the DMFC system is attributable to the increase of methanol crossover that can be observed for an individual cell. A DMFC system can achieve maximum energy density and fuel efficiency at an appropriately high level of power output. Published by Elsevier B.V. C1 US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Jiang, RZ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM RJiang@ARL.Army.MiL NR 26 TC 10 Z9 10 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD OCT 27 PY 2006 VL 161 IS 2 BP 1192 EP 1197 DI 10.1016/j.jpowsour.2006.05.027 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 101ZU UT WOS:000241781200056 ER PT J AU Zhang, SS AF Zhang, Sheng Shui TI The effect of the charging protocol on the cycle life of a Li-ion battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Li-ion battery; 18650 cell; charging; cycle life; impedance ID LITHIUM; CELLS AB The effect of the charging protocol on the cycle life of a commercial 18650 Li-ion cell was studied using three methods: (1) constant current (CC) charging, (2) constant power (CP) charging, and (3) multistage constant current (MCC) charging. The MCC-charging consists of two CC steps, which starts with a low current to charge the initial 10% capacity followed by a high current charging until the cell voltage reaches 4.2 V. Using these methods, respectively, the cell was charged to 4.2 V followed by a constant voltage (CV) charging until the current declined to 0.05 C. Results showed that the cycle life of the cell strongly depended on the charging protocol even if the same charging rate was used. Among these three methods, the CC-method was found to be more suitable for slow charging (0.5 C) while the CP-method was better for fast charging (1 C). Impedance analyses indicated that the capacity loss during cycling was mainly attributed to the increase of charge-transfer resistance as a result of the progressive growth of surface layers on the surface of two electrodes. Fast charging resulted in an accelerated capacity fading due to the loss of Li(+) ions and the related growth of a surface layer, which was associated with metallic lithium plating onto the at ode and a high polarization at the electrolyte-electrode interface. Analyses of the cell electrochemistry showed that use of a reduced current to charge the initial 10% capacity and near the end of charge, respectively, was favorable for long cycle life. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD, ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD, ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 14 TC 125 Z9 137 U1 8 U2 77 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT 27 PY 2006 VL 161 IS 2 BP 1385 EP 1391 DI 10.1016/j.jpowsour.2006.06.040 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 101ZU UT WOS:000241781200081 ER PT J AU Federici, JA Norton, DG Bruggemann, T Voit, KW Wetzel, ED Vlachos, DG AF Federici, J. A. Norton, D. G. Bruggemann, T. Voit, K. W. Wetzel, E. D. Vlachos, D. G. TI Catalytic microcombustors with integrated thermoelectric elements for portable power production SO JOURNAL OF POWER SOURCES LA English DT Article DE microburners; thermoelectrics; power generation; heat transfer; temperature uniformity; stability; extinction; hydrogen; propane ID COMBUSTOR/REFORMER MICRODEVICES; HYDROGEN-PRODUCTION; COMBUSTION; CFD; STABILITY; GENERATOR; MIXTURES; SYSTEMS AB In this study, catalytic microcombustors are integrated with thermoelectrics to produce electricity. The devices are found to be robust, easy to start up, and able to support complete combustion over a range of fuels (e.g., C(3)H(8)/air and H(2)/air systems) at different flowrates. Various materials of construction for the microcombustors are investigated in order to yield good temperature uniformity, which is shown to increase electrical power output and efficiency. Electrical power generation from catalytic microcombustion with a thermal efficiency up to similar to 0.8% is measured. Parameters affecting energy efficiency are also discussed. (c) 2006 Elsevier B.V. All rights reserved. C1 Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vlachos, DG (reprint author), Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. EM vlachos@udel.edu OI Vlachos, Dionisios/0000-0002-6795-8403 NR 24 TC 81 Z9 84 U1 1 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT 27 PY 2006 VL 161 IS 2 BP 1469 EP 1478 DI 10.1016/j.jpowsour.2006.06.042 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 101ZU UT WOS:000241781200092 ER PT J AU Michalkova, A Martinez, J Zhikol, OA Gorb, L Shishkin, OV Leszczynska, D Leszczynski, J AF Michalkova, A. Martinez, J. Zhikol, O. A. Gorb, L. Shishkin, O. V. Leszczynska, D. Leszczynski, J. TI Theoretical study of adsorption of Sarin and Soman on tetrahedral edge clay mineral fragments SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-ORBITAL METHODS; GAUSSIAN-TYPE BASIS; DIMETHYL METHYLPHOSPHONATE; HYDROLYSIS PRODUCTS; MASS-SPECTROMETRY; ORGANIC-MOLECULES; HYDROGEN-BONDS; ALUMINUM-OXIDE; AB-INITIO; GLYPHOSATE AB This study provides details of the structure and interactions of Sarin and Soman with edge tetrahedral fragments of clay minerals. The adsorption mechanism of Sarin and Soman on these mineral fragments containing the Si4+ and Al3+ central cations was investigated. The calculations were performed using the B3LYP and MP2 levels of theory in conjunction with the 6-31G(d) basis set. The studied systems were fully optimized. Optimized geometries, adsorption energies, and Gibbs free energies of Sarin and Soman adsorption complexes were computed. The number and strength of formed intermolecular interactions have been analyzed using the AIM theory. The charge of the systems and a termination of the mineral fragment are the main contributing factors on the formation of intermolecular interactions in the studied systems. In the neutral complexes, Sarin and Soman is physisorbed on these mineral fragments due to the formation of C-(HO)-O-..., and O- (HO)-O-... hydrogen bonds. The chemical bond is formed between a phosphorus atom of Sarin and Soman and an oxygen atom of the -2 charged clusters containing an Al3+ central cation and -1 charged complex containing a Si4+ central cation (chemisorption). Sarin and Soman interact mostly in the same way with the same terminated edge mineral fragments containing different central cations. However, the interaction energies of the complexes with an Al3+ central cation are larger than these values for the Si4+ complexes. The interaction enthalpies of all studied systems corrected for the basis set superposition error were found to be negative. However, on the basis of the Gibbs free energy values, only strongly interacting complexes containing a charged edge mineral fragment with an Al3+ central cation are stable at room temperature. We can conclude that Sarin and Soman will be adsorbed preferably on this type of edge mineral surfaces. Moreover, on the basis of the character of these edge surfaces, a tetrahedral edge mineral fragment can provide effective centers for the dissociation. C1 Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. Florida State Univ, Coll Engn, FAMU FSU, Dept Civil & Environm Engn, Tallahassee, FL 32306 USA. USA, Erdc, Vicksburg, MS 39180 USA. Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine. Pontificia Univ Catolica Chile, Dept Quim Fis, Fac Quim, QTC, Santiago, Chile. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, 1400 J R Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Martinez-Araya, Jorge/F-3294-2016 OI Martinez-Araya, Jorge/0000-0002-2769-7640 NR 56 TC 16 Z9 16 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD OCT 26 PY 2006 VL 110 IS 42 BP 21175 EP 21183 DI 10.1021/jp062306j PG 9 WC Chemistry, Physical SC Chemistry GA 096MQ UT WOS:000241381600069 PM 17048942 ER PT J AU Liu, F Stephen, AG Adamson, CS Gousset, K Aman, MJ Freed, EO Fisher, RJ Burke, TR AF Liu, Fa Stephen, Andrew G. Adamson, Catherine S. Gousset, Karine Aman, M. Javad Freed, Eric O. Fisher, Robert J. Burke, Terrence R., Jr. TI Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: Application to the preparation of Tsg101-directed HIV-1 budding antagonists SO ORGANIC LETTERS LA English DT Article ID SOLID-PHASE SYNTHESIS; FLUORESCENCE ANISOTROPY; PROTEIN; PEPTIDOMIMETICS; INHIBITORS; DISCOVERY; OLIGOMERS; PEPTIDES; SEQUENCE; RECEPTOR AB Replacing the Pro6 in the p6(Gag)-derived 9-mer "P-E-P-T-A-(P) under bar -P-E-E" with N-substituted glycine (NSG) residues is problematic. However, incorporation of hydrazone amides ("peptoid hydrazones") can be readily achieved in library fashion. Furthermore, reduction of these hydrazones to N-substituted "peptoid hydrazides" affords a facile route to library diversification. This approach is demonstrated by application to Tsg101-binding compounds designed as potential HIV budding antagonists. C1 NCI Frederick, Med Chem Lab, CCR, NIH, Frederick, MD 21702 USA. SAIC Frederick Inc, Prot Chem Lab, Frederick, MD 21702 USA. NCI Frederick, Hiv Drug Resistance Program, CCR, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Burke, TR (reprint author), NCI Frederick, Med Chem Lab, CCR, NIH, Bldg 376,Boyles St, Frederick, MD 21702 USA. EM tburke@helix.nih.gov RI Fisher, Robert/B-1431-2009; Burke, Terrence/N-2601-2014; OI Gousset, Karine/0000-0002-0988-2332 FU Intramural NIH HHS [Z01 BC007363-13]; NCI NIH HHS [N01 CO 12400, N01CO12400] NR 22 TC 29 Z9 32 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD OCT 26 PY 2006 VL 8 IS 22 BP 5165 EP 5168 DI 10.1021/ol0622211 PG 4 WC Chemistry, Organic SC Chemistry GA 096MS UT WOS:000241381800046 PM 17048869 ER PT J AU Huso, J Morrison, JL Hoeck, H Chen, XB Bergman, L Jokela, SJ McCluskey, MD Zheleva, T AF Huso, Jesse Morrison, John L. Hoeck, Heather Chen, Xiang-Bai Bergman, Leah Jokela, S. J. McCluskey, M. D. Zheleva, Tsvetanka TI Pressure response of the ultraviolet photoluminescence of ZnO and MgZnO nanocrystallites SO APPLIED PHYSICS LETTERS LA English DT Article ID OPTICAL-PROPERTIES; CDSE NANOCRYSTALS; BAND-GAP; EXCITON; DEPENDENCE; TRANSFORMATION; TRANSITION; NANOWIRES; MGXZN1-XO; SAPPHIRE AB The pressure response of the ultraviolet photoluminescence of ZnO nanocrystallites and MgZnO nanoalloy of composition 15% Mg:85% Zn of the wurtzite structure was studied. The authors found that up to 7 GPa the pressure coefficients of ZnO and MgZnO are 23.6 and 27.1 meV/GPa, respectively. The pressure coefficient of the ZnO nanocrystallites is similar to that reported elsewhere for bulk ZnO material. The higher value found for MgZnO is discussed in terms of the d orbitals of the alloy constituents and their compliance to stress. Additionally, the volume deformation potential was derived from the experimental results. (c) 2006 American Institute of Physics. C1 Univ Idaho, Dept Phys, Moscow, ID 83844 USA. Washington State Univ, Dept Phys, Pullman, WA 99164 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Bergman, L (reprint author), Univ Idaho, Dept Phys, Moscow, ID 83844 USA. EM lbergman@uidaho.edu RI Chen, Xiang-Bai/B-7052-2012 NR 32 TC 15 Z9 15 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 23 PY 2006 VL 89 IS 17 AR 171909 DI 10.1063/1.2369917 PG 3 WC Physics, Applied SC Physics GA 099IB UT WOS:000241585800035 ER PT J AU Merrill, GA Riaera, VR Neal, DD Young, C Poli, MA AF Merrill, Gerald A. Riaera, Victor R. Neal, Dwayne D. Young, Charles Poli, Mark A. TI A quantitative electrochemiluminescence assay for Clostridium perfringens alpha toxin SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE electrochemiluminescence (ECL); immunoassay; Clostridium perfringens; alpha toxin; gangrene; PLC ID COLORIMETRIC CAPTURE ELISAS; PHOSPHOLIPASE-C; ENTEROTOXIN-A; ENZYME; CLONING; DEATH AB Described is a rapid direct sandwich format electrochemiluminescence assay for identifying and assaying Clostridium perfringens alpha toxin. Biotinylated antibodies to C pet firingens alpha toxin bound to streptavidin paramagnetic beads specifically immunoadsorbed soluble sample alpha toxin which subsequently selectively immunoadsorbed ruthenium (Ru)-labeled detection antibodies. The ruthenium chelate of detection antibodies chemically reacted in the presence of tripropylamine and upon electronic stimulation emitted photons (electrochemiluminescence) that were detected by the photodiode of the detector. Elevated toxin concentrations increased toxin immunoadsorption and the specific immunoadsorption of Ru-labeled antibodies to alpha toxin, which resulted in increased dose-dependent electrochemiluminescent signals. The standardized assay was rapid (single 2.5-h coincubation of all reagents), required no wash steps, and had a sensitivity of about 1 ng/ml of toxin. The assay had excellent accuracy and precision and was validated in buffer, serum, and urine with no apparent matrix effects. (c) 2006 Elsevier Inc. All rights reserved. C1 Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. BioVeris Corp, Gaithersburg, MD 20877 USA. RP Merrill, GA (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave,STE A, Ft Sam Houston, TX 78234 USA. EM Gerald.Merrill@Amedd.Army.Mil NR 26 TC 6 Z9 8 U1 1 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD OCT 15 PY 2006 VL 357 IS 2 BP 181 EP 187 DI 10.1016/j.ab.2006.07.010 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 092DS UT WOS:000241077800004 PM 16949539 ER PT J AU Keener, WK Rivera, VR Young, CC Poli, MA AF Keener, William K. Rivera, Victor R. Young, Charles C. Poli, Mark A. TI An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE ricin; abrin; saporin; electrochemiluminescence; activity; N-glycosidase; ribosome inactivating protein; immunoassay; bioterrorism ID RIBOSOME-INACTIVATING PROTEINS; A-CHAIN; DNA; TOXINS; SUBSTRATE; REAGENTS; LOOP; SEED; CHROMATOGRAPHY; CONTAMINATION AB Synthetic biotinylated RNA substrates were cleaved by the combined actions of ricin holotoxin and a chemical agent, N,N'-dimethylethylenediamine. The annealing of the product with a ruthenylated oligodeoxynucleotide resulted in the capture of ruthenium chelate onto magnetic beads, enabling the electrochemiluminescence (ECL)-based detection of RNA N-glycosidase activities of toxins. ECL immunoassays and the activity assay exhibited similar limits of detection just below signals with 0.1 ng/ml of ricin; the ECL response was linear as the ricin concentration increased by two orders of magnitude. Activities were detected with other adenine-specific RNA N-glycosidases, including Ricinus communis agglutinin (RCA), saporin, and abrin II. The substrate that provided the greatest sensitivity was composed of a four-residue loop, GdAGA, in a hairpin structure. When the 2'-deoxyadenosine (dA) was substituted with adenosine (A), 2'-deoxyinosine, or 2'-deoxyuridine, toxin-dependent signals were abolished. Placing the GdAGA motif in a six-residue loop or replacing it with GdAdGA or GdAAA resulted in measurable activities and signal patterns that were reproducible for a given toxin. Data indicated that saporin and abrin II shared one pattern, while ricin and RCA shared a distinct pattern. A monoclonal antibody that enhanced the activities of ricin, RCA, and abrin II to different extents, thus improving the diagnostic potential of the assay, was identified. (c) 2006 Elsevier Inc. All rights reserved. C1 USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. BioVeris Corp, Gaithersburg, MD USA. RP Keener, WK (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM william.keener@amedd.army.mil NR 27 TC 22 Z9 22 U1 1 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD OCT 15 PY 2006 VL 357 IS 2 BP 200 EP 207 DI 10.1016/j.ab.2006.07.005 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 092DS UT WOS:000241077800007 PM 16942744 ER PT J AU Anaissie, EJ Segal, BH Graybill, JR Arndt, C Perfect, JR Kleinberg, M Pappas, P Benjamin, D Rubin, R Aberg, JA Adderson, EE Adler-Shohet, FC Akan, H Akova, M Almyroudis, NG Alexander, BD Andes, D Arrieta, A Baddley, JW Barron, MA Belzberg, H Boucher, HW Boyce, TG Casadevall, A Chandrasekar, PH Cleary, JD Cordonnier, C Cornely, OA Cuenca-Estrella, M Daly, JS Daoura, N Denning, DW dePauw, B de Repentigny, L Dignani, MC Dismukes, WE Donnelly, JP Donowitz, GR Dupont, B Drusano, G Ellis, M Espinel-Ingroff, A Fishman, JA Fleming, R Forrest, G Ghannoum, M Goldman, M Grazziutti, M Greene, JN Greenberg, RN Gubbins, PO Hadley, S Herbrecht, R Hiemenz, JW Hope, W Hospenthal, DR Husain, S Ito, JI Jacobson, RM Johnson, M Keating, MR Kett, DH Knapp, K Kontoyiannis, DP Krcmery, VC Larsen, R Laverdiere, M Ljungman, P Lortholary, O Maertens, J Marriott, D Mattiuzzi, G McGinnis, MR Morris, M Nucci, M Odds, FC Pankey, GA Patterson, T Pfaller, M Razonable, RR Reboli, AC Rinaldi, MG Roberts, GD Tudela, JL Rotstein, C Ruhnke, M Schuster, M Shoham, S Sia, IG Siebel, N Silviera, F Singh, N Sobel, J Solomkin, JS Sorrell, TC Steinbach, WJ Temesgen, Z Tortorano, A Vartivarian, S VerWeij, P Viscoli, C Viviani, MA Walker, RC Wheat, JL Wiley, J Williamson, P Wingard, JR Yu, VL Zaoutis, T AF Anaissie, Elias J. Segal, Brahm H. Graybill, John R. Arndt, Carola Perfect, John R. Kleinberg, Michael Pappas, Peter Benjamin, Danny Rubin, Robert Aberg, Judith A. Adderson, Elisabeth E. Adler-Shohet, Felice C. Akan, Hamdi Akova, Murat Almyroudis, Nikolaos G. Alexander, Barbara D. Andes, David Arrieta, Antonio Baddley, John W. Barron, Michelle A. Belzberg, Howard Boucher, Helen W. Boyce, Thomas G. Casadevall, Arturo Chandrasekar, P. H. Cleary, John D. Cordonnier, Catherine Cornely, Oliver A. Cuenca-Estrella, Manuel Daly, Jennifer S. Daoura, Nicholas Denning, David W. dePauw, Ben de Repentigny, Louis Dignani, Maria Cecilia Dismukes, William E. Donnelly, J. Peter Donowitz, Gerald R. Dupont, Bertrand Drusano, George Ellis, Michael Espinel-Ingroff, Ana Fishman, Jay A. Fleming, Rhonda Forrest, Graeme Ghannoum, Mahmoud Goldman, Mitchell Grazziutti, Monica Greene, John N. Greenberg, Richard N. Gubbins, Paul O. Hadley, Susan Herbrecht, Raoul Hiemenz, John W. Hope, William Hospenthal, Durane R. Husain, Shahid Ito, James I. Jacobson, Robert M. Johnson, Melissa Keating, Michael R. Kett, Daniel H. Knapp, Katherine Kontoyiannis, Dimitrios P. Krcmery, Vladimir C. Larsen, Robert Laverdiere, Michel Ljungman, Per Lortholary, O. Maertens, Johan Marriott, Debbie Mattiuzzi, Gloria McGinnis, Michael R. Morris, Michele Nucci, Marcio Odds, Frank C. Pankey, George A. Patterson, Thomas Pfaller, Mike Razonable, Raymond R. Reboli, Annette C. Rinaldi, Michael G. Roberts, Glenn D. Rodriguez Tudela, Juan Luis Rotstein, Coleman Ruhnke, Markus Schuster, Mindy Shoham, Shmuel Sia, Irene G. Siebel, Nita Silviera, Fernanda Singh, Nina Sobel, Jack Solomkin, Joseph S. Sorrell, Tania C. Steinbach, William J. Temesgen, Zelalem Tortorano, AnnaMaria Vartivarian, Shahe VerWeij, Paul Viscoli, Claudio Viviani, Maria Anna Walker, Randall C. Wheat, Joseph L. Wiley, Joseph Williamson, Peter Wingard, John R. Yu, Victor L. Zaoutis, Theoklis TI Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material ID LIPOSOMAL AMPHOTERICIN-B; EMPIRICAL ANTIFUNGAL THERAPY; ACUTE-RENAL-FAILURE; INVASIVE ASPERGILLOSIS; NEUTROPENIC PATIENTS; PERSISTENT FEVER; DOUBLE-BLIND; CASPOFUNGIN; CANCER; SAFETY C1 Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Dept Pharm Practice, Little Rock, AR 72205 USA. Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA. Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA. Univ Texas, MD Anderson Canc Ctr, Dept Med, Houston, TX 77030 USA. Metropolitan Infect Dis, Houston, TX USA. Texas Tech Univ, Hlth Sci Ctr, Div Infect Dis, El Paso, TX USA. Univ Texas, Dept Pathol, Galveston, TX 77555 USA. Univ Texas, Dept Dermatol, Galveston, TX 77555 USA. Univ Texas, Dept Microbiol & Immunol, Galveston, TX 77555 USA. Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Univ Maryland, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA. Childrens Hosp Sinai, Div Pediat Hematol Oncol, Dept Pediat, Baltimore, MD USA. NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA. St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA. Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38163 USA. Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA. Univ Pittsburgh, Div Infect Dis, Dept Med, Pittsburgh, PA USA. Childrens Hosp Philadelphia, Dept Pediat & Epidemiol, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. Univ Penn, Med Ctr, Div Infect Dis, Dept Med, Philadelphia, PA 19104 USA. Ochsner Clin Fdn, New Orleans, LA USA. Louisiana State Univ, Feist Weiller Canc Ctr, Hlth Sci Ctr, Shreveport, LA 71105 USA. Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA. Duke Univ, Med Ctr, Dept Med Genet, Durham, NC 27710 USA. Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA. Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. Duke Univ, Med Ctr, Div Infect Dis, Durham, NC 27710 USA. Duke Univ, Med Ctr, Clin Mycol Lab, Durham, NC 27710 USA. Duke Univ, Duke Clin Res Inst, Durham, NC 27710 USA. Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. Tufts Univ, Sch Med, Div Geog Med, Tufts New England Med Ctr, Boston, MA 02111 USA. Tufts Univ, Sch Med, Div Infect Dis, Tufts New England Med Ctr, Boston, MA 02111 USA. Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA. Univ So Calif, Keck Sch Med, Dept Med, Los Angeles, CA USA. Crit Care Serv, Los Angeles, CA USA. Univ So Calif, Med Ctr, Los Angeles, CA USA. Childrens Hosp Orange Cty, Los Angeles, CA USA. Miller Childrens Hosp, Long Beach, CA USA. City Hope Natl Med Ctr, Dept Infect Dis, Duarte, CA 91010 USA. Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA USA. Univ Florida, Coll Med, Dept Infect Dis, H Lee Moffitt Canc Ctr, Tampa, FL USA. Jackson Mem Hosp, Med Intens Care Unite, Miami, FL 33136 USA. Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33152 USA. Mayo Clin, Coll Med, Div Infect Dis, Dept Med, Jacksonville, FL 32224 USA. Univ Florida, Coll Med, Dept Med, Div Hematol Oncol, Gainesville, FL USA. Indiana Univ, Sch Med, Dept Med, Immunocompromised Infect Dis Serv, Indianapolis, IN 46204 USA. MiraVista Diagnost MiraBella Technol, Indianapolis, IN USA. Univ Colorado, Dept Med, Div Infect Dis, Denver, CO 80202 USA. Univ Wisconsin, Dept Med, Madison, WI USA. Univ Wisconsin, Dept Microbiol, Madison, WI USA. Univ Virginia, Hlth Syst, Dept Med, Charlottesville, VA USA. Virginia Commonwealth Univ, Med Ctr, Dept Med, Richmond, VA USA. Mayo Clin, Div Clin Microbiol, Rochester, NY USA. Mayo Clin, Dept Pediat, Rochester, NY USA. Mayo Clin, Dept Med, Div Infect Dis, Rochester, NY USA. Mayo Clin, Coll Med, Dept Med, Div Infect Dis, Buffalo, NY USA. Univ Alabama, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA. NYU, Sch Med, New York, NY USA. Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY USA. Roswell Pk Canc Ctr, Div Infect Dis, Buffalo, NY USA. Albany Med Coll, Div Clin Pharmacol, Albany, NY USA. Univ Mississippi, Med Ctr, Sch Pharm, Dept Pharm Practice, Jackson, MS 39216 USA. Univ Mississippi, Med Ctr, Sch Med, Jackson, MS 39216 USA. Univ Mississippi, Med Ctr, Mycot Res Ctr, Dept Med,Div Infect Dis, Jackson, MS 39216 USA. Univ Kentucky, Sch Med, Div Infect Dis, Dept Internal Med, Lexington, KY 40536 USA. Washington Hosp Ctr, Washington, DC 20010 USA. Georgetown Univ, Sch Med, Dept Med, Washington, DC USA. George Washington Univ, Sch Med & Publ Hlth, Dept Pediat, Washington, DC USA. Childrens Natl Med Ctr, Dept Hematol Oncol, Washington, DC 20010 USA. Case Western Reserve Univ, Sch Med, Dept Dermatol, Cleveland, OH 44106 USA. Univ Cincinnati, Div Trauma & Crit Care, Dept Surg, Cincinnati, OH USA. Wayne State Univ, Div Infect Dis, Detroit, MI USA. Cooper Univ Hosp, Robert Wood Johnson Med Sch, Dept Med, Div Infect Dis, Camden, NJ USA. Univ Chicago, Dept Med, Chicago, IL 60637 USA. Univ Aberdeen, Dept Mycol, Aberdeen AB9 1FX, Scotland. Wythenshawe Hosp, Dept Med, Educ Res Ctr, Manchester M23 9LT, Lancs, England. Wythenshawe Hosp, Dept Med Mycol, Educ Res Ctr, Manchester M23 9LT, Lancs, England. Catholic Univ Louvain, Dept Clin Haematol, B-3000 Louvain, Belgium. Univ Nijmegen Hosp, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands. Univ Nijmegen Hosp, Dept Hematol, NL-6500 HB Nijmegen, Netherlands. Radboud Univ Nijmegen Med Ctr, Dept Haematol, Nijmegen, Netherlands. Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands. Karolinska Inst, Dept Med, Stockholm, Sweden. Karolinska Univ Hosp, Hematol Ctr, Stockholm, Sweden. Hosp Maisonneuve Rosemont, Dept Microbiol Infect Dis, Montreal, PQ, Canada. Univ Montreal, Hop St Justine, Dept Microbiol & Immunol, Montreal, PQ H3T 1C5, Canada. McMaster Univ, Div Infect Dis, Hamilton, ON, Canada. Hamilton Hlth Serv, Infect Dis Serv, Hamilton, ON, Canada. Hop Necker Enfants Malad, Serv Malad Infect & Trop, Paris, France. CHU Henri Mondor, Dept Hematol, F-94010 Creteil, France. Hop Hautepierre, Dept Hematol & Oncol, Strasbourg, France. Univ Fed Rio de Janeiro, Univ Hosp, Rio De Janeiro, Brazil. Univ Cologne, Dept Internal Med, Cologne, Germany. Charite Univ Med, Med Klin & Poliklin 2, Berlin, Germany. Fdn Fight Against Leukemia, Dept Infect Dis, Buenos Aires, DF, Argentina. Univ Milan, Dept Publ Hlth Microbiol & Virol, Milan, Italy. Univ Genoa, Div Infect Dis, San Martino Univ Hosp, Genoa, Italy. Ankara Univ, Dept Hematol, TR-06100 Ankara, Turkey. Ankara Univ, Bone Marrow Transplant Unit, TR-06100 Ankara, Turkey. Hacettepe Univ, Sch Med, Dept Med, Ankara, Turkey. Univ Sydney, Westmead Hosp, Ctr Infect Dis & Microbiol, Dept Infect Dis, Westmead, NSW 2145, Australia. St Vincents Hosp, Dept Clin Microbiol & Infect Dis, Darlinghurst, NSW 2010, Australia. Inst Salud Carlos III, Dept Mycol, Spanish Natl Ctr Microbiol, Madrid, Spain. United Arab Emirates Med Sch, Dept Med, Al Ain, U Arab Emirates. RP Anaissie, EJ (reprint author), Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, 4301 W Markham,Slot 816, Little Rock, AR 72205 USA. EM anaissieeliasj@uams.edu RI Nucci, Marcio/G-4515-2012; Herbrecht, Raoul/D-3471-2013; Verweij, P.E./H-8108-2014; OI Nucci, Marcio/0000-0003-4867-0014; Dignani, Maria Cecilia/0000-0002-7446-6183; Johnson, Melissa/0000-0002-6606-9460; Tortorano, Anna Maria/0000-0003-2093-8250; Herbrecht, Raoul/0000-0002-9381-4876; Denning, David/0000-0001-5626-2251; Jacobson, Robert/0000-0002-6355-8752; Hope, William/0000-0001-6187-878X NR 18 TC 2 Z9 2 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2006 VL 43 IS 8 BP 1031 EP 1039 DI 10.1086/509116 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 086IE UT WOS:000240666200013 PM 16983616 ER PT J AU Aronson, NE Sanders, JW Moran, KA AF Aronson, Naomi E. Sanders, John W. Moran, Kimberly A. TI In harm's way: Infections in deployed American military forces SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID OPERATIONS IRAQI FREEDOM; US MILITARY; Q-FEVER; ENDURING FREEDOM; WAR WOUNDS; AFGHANISTAN; INJURY; GASTROENTERITIS; LEISHMANIASIS; ENDOCARDITIS AB Hundreds of thousands of American service members have been deployed to Afghanistan and Iraq since 2001. With emphasis on the common infections and the chronic infections that may present or persist on their return to the United States, we review the data on deployment-associated infections. These infections include gastroenteritis; respiratory infection; war wound infection with antibiotic-resistant, gram-negative bacteria; Q fever; brucellosis; and parasitic infections, such as malaria and leishmaniasis. C1 Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA. Natl Naval Med Ctr, Infect Dis Serv, Bethesda, MD USA. Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Aronson, NE (reprint author), 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM naronson@usuhs.mil NR 50 TC 93 Z9 100 U1 2 U2 16 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 15 PY 2006 VL 43 IS 8 BP 1045 EP 1051 DI 10.1086/507539 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 086IE UT WOS:000240666200016 PM 16983619 ER PT J AU Tulve, NS Jones, PA Nishioka, MG Fortmann, RC Croghan, CW Zhou, JY Fraser, A Cave, C Friedman, W AF Tulve, Nicolle S. Jones, Paul A. Nishioka, Marcia G. Fortmann, Roy C. Croghan, Carry W. Zhou, Joey Y. Fraser, Alexa Cave, Carol Friedman, Warren TI Pesticide measurements from The First National Environmental Health Survey of Child Care Centers using a multi-residue GC/MS analysis method SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERSISTENT ORGANIC POLLUTANTS; EVERYDAY ENVIRONMENTS; PRESCHOOL-CHILDREN; EXPOSURES AB The U. S. Department of Housing and Urban Development, in collaboration with the U. S. Consumer Product Safety Commission and the U. S. Environmental Protection Agency, characterized the environments of young children (< 6 years) by measuring lead, allergens, and pesticides in a randomly selected nationally representative sample of licensed institutional child care centers. Multi-stage sampling with clustering was used to select 168 child care centers in 30 primary sampling units in the United States. Centers were recruited into the study by telephone interviewers. Samples for pesticides, lead, and allergens were collected at multiple locations in each center by field technicians. Field sampling was conducted from July through October 2001. Wipe samples from indoor surfaces (floors, tabletops, desks) and soil samples were collected at the centers and analyzed using a multi-residue GC/MS analysis method. Based on the questionnaire responses, pyrethroids were the most commonly used pesticides among centers applying pesticides. Among the 63% of centers reporting pesticide applications, the number of pesticides used in each center ranged from 1 to 10 and the frequency of use ranged from 1 to 107 times annually. Numerous organophosphate and pyrethroid pesticides were detected in the indoor floor wipe samples. Chlorpyrifos (0.004-28 ng/cm(2)), diazinon (0.002-18 ng/cm(2)), cis-permethrin (0.004-3 ng/cm(2)), and trans-permethrin (0.004-7 ng/cm(2)) were detected in > 67% of the centers. Associations exist between residues measured on the floor and other surfaces for several pesticides (p-values range from < 0.0001 to 0.002), but to a lesser degree between floor and soil and other surfaces and soil. Regional analyses indicate no differences in mean level of pesticide loading between the four Census regions (0.08 < p < 0.88). Results show that there is the potential for exposure to pesticides in child care centers. C1 US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. Battelle Mem Inst, Columbus, OH 43201 USA. USA, Ctr Hlth Promot & Prevent Med, Environm Med Program, Aberdeen Proving Ground, MD 20101 USA. Westat Corp, Rockville, MD 20850 USA. US Consumer Prod Safety Commiss, Bethesda, MD 20814 USA. US Dept Housing & Urban Dev, Off Healthy Homes & Lead Hazard Control, Washington, DC 20410 USA. RP Tulve, NS (reprint author), US EPA, Natl Exposure Res Lab, MD-E20504, Res Triangle Pk, NC 27709 USA. EM tulve.nicolle@epa.gov NR 17 TC 60 Z9 60 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 15 PY 2006 VL 40 IS 20 BP 6269 EP 6274 DI 10.1021/es061021h PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 093TM UT WOS:000241192600018 PM 17120552 ER PT J AU Zhang, H Chen, MW Ramesh, KT Ye, J Schoenung, JM Chin, ESC AF Zhang, H. Chen, M. W. Ramesh, K. T. Ye, J. Schoenung, J. M. Chin, E. S. C. TI Tensile behavior and dynamic failure of aluminum 6092/B4C composites SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE metal matrix composites; powder consolidation; plastic deformation; dynamic failure; interface structure ID METAL-MATRIX COMPOSITE; PARTICLE-REINFORCED ALUMINUM; AL-SIC COMPOSITES; MECHANICAL-PROPERTIES; STRAIN-RATE; CERAMIC COMPOSITES; RESIDUAL-STRESSES; DEFORMATION; FRACTURE; SIZE AB Aluminum 6092/(B4C)(p) metal matrix composites fabricated by two different powder consolidation routes, extrusion (EXTR) and sintering/hot isostatic-pressing (HIP), were made and tested over a wide range of strain rates (10(-4) to (3 x 10(2))s(-1)) under tension. A tension-compression asymmetry of constitutive behavior is observed: the flow strength and ductility of these composites under tension are lower than those under compression. Such asymmetry is reinforcement volume fraction dependent, and the extent of asymmetry is larger for HIP composites. Fractographic observations show different interfacial bonding characteristics (good bonding for the EXTR composites and relatively weak bonding for the HIP composites), indicating a strong effect of interfacial debonding on the constitutive and failure behavior of these composites. TEM observations reveal a weak amorphous layer composed mainly of aluminum, magnesium and carbon along Al/B4C interface in the HIP composites, which is consistent with the experimental observations. (c) 2006 Elsevier B.V. All rights reserved. C1 Univ Texas, Dept Aerosp Engn & Engn Mech, Austin, TX 78712 USA. Tohoku Univ, Inst Mat Res, Aoba Ku, Sendai, Miyagi 9808577, Japan. Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, H (reprint author), Univ Texas, Dept Aerosp Engn & Engn Mech, Austin, TX 78712 USA. EM htzhang@mail.utexas.edu RI Chen, Mingwei/A-4855-2010 OI Chen, Mingwei/0000-0002-2850-8872 NR 49 TC 24 Z9 28 U1 4 U2 30 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 15 PY 2006 VL 433 IS 1-2 BP 70 EP 82 DI 10.1016/j.msea.2006.06.055 PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 088OQ UT WOS:000240821400010 ER PT J AU Fernandes, GE Pan, YL Chang, RK Aptowicz, K Pinnick, RG AF Fernandes, Gustavo E. Pan, Yong-Le Chang, Richard K. Aptowicz, Kevin Pinnick, Ronald G. TI Simultaneous forward- and backward-hemisphere elastic-light-scattering patterns of respirable-size aerosols SO OPTICS LETTERS LA English DT Article ID OPTICAL-SCATTERING; PARTICLES; CLASSIFICATION; BACTERIA; LASER AB Two-dimensional angular optical scattering (TAOS) patterns of aerosols are measured simultaneously from the forward hemisphere 15 degrees < theta < 90 degrees as well as the backward hemisphere 90 degrees < theta < 165 degrees (detecting 63% of the 4 pi sr of scattered light) by using an ellipsoidal reflector and an intensified CCD detector. TAOS patterns were obtained from polystyrene-latex spheres (individuals and aggregates) and from single Bacillus subtilis spores. These information-rich patterns, measured with a single laser pulse for individual particles on the fly, suggest that forward-TAOS and backward-TAOS measurements may be used for rapid classification of single aerosol particles. (c) 2006 Optical Society of America. C1 Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA. W Chester Univ, Dept Phys, W Chester, PA 19383 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Fernandes, GE (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. EM gustavo.fernandes@yale.edu NR 14 TC 23 Z9 23 U1 0 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD OCT 15 PY 2006 VL 31 IS 20 BP 3034 EP 3036 DI 10.1364/OL.31.003034 PG 3 WC Optics SC Optics GA 092RY UT WOS:000241116200027 PM 17001391 ER PT J AU Whitman, JM Flynn, TW Childs, JD Wainner, RS Gill, HE Ryder, MG Garber, MB Bennett, AC Fritz, JM AF Whitman, Julie M. Flynn, Timothy W. Childs, John D. Wainner, Robert S. Gill, Howard E. Ryder, Michael G. Garber, Matthew B. Bennett, Andrew C. Fritz, Julie M. TI A comparison between two physical therapy treatment programs for patients with lumbar spinal stenosis - A randomized clinical trial SO SPINE LA English DT Article DE lumbar spine; stenosis; spinal stenosis; physical therapy; rehabilitation; physiotherapy; RCT; clinical trial ID LOW-BACK-PAIN; UNITED-STATES TRENDS; HEALTH-STATUS; CONSERVATIVE TREATMENT; SURGERY; DECOMPRESSION; RESPONSIVENESS; COMPLICATIONS; MANAGEMENT; SCIATICA AB Study Design. Multicenter randomized, controlled trial. Objective. To compare two physical therapy programs for patients with lumbar spinal stenosis. Summary of Background Data. Scant evidence exists regarding effectiveness of nonsurgical management programs for lumbar spinal stenosis. Methods. Fifty-eight patients with lumbar spinal stenosis were randomized to one of two 6-week physical therapy programs. One program included manual physical therapy, body weight supported treadmill walking, and exercise (Manual Physical Therapy, Exercise, and Walking Group), while the other included lumbar flexion exercises, a treadmill walking program, and subtherapeutic ultrasound (Flexion Exercise and Walking Group). Perceived recovery was assessed with a global rating of change scale. Secondary outcomes included: Oswestry, a numerical pain rating scale, a measure of satisfaction, and a treadmill test. Testing occurred at baseline, 6 weeks, and 1 year. Perceived recovery, pain, and other healthcare resources used were collected with a long-term follow-up questionnaire. Results. A greater proportion of patients in the manual physical therapy, exercise, and walking group reported recovery at 6 weeks compared with the flexion exercise and walking group (P = 0.0015), with a number needed to treat for perceived recovery of 2.6 (confidence interval, 1.8 - 7.8). At 1 year, 62% and 41% of the manual therapy, exercise, and walking group and the flexion exercise and walking group, respectively, still met the threshold for recovery. Improvements in disability, satisfaction, and treadmill walking tests favored the manual physical therapy, exercise, and walking group at all follow-up points. Conclusions. Patients with lumbar spinal stenosis can benefit from physical therapy. Additional gains may be realized with the inclusion of manual physical therapy interventions, exercise, and a progressive body-weight supported treadmill walking program. C1 Regis Univ, Dept Phys Therapy, Denver, CO 80221 USA. USA, Baylor Doctoral Program Phys Therapy, San Antonio, TX USA. Texas Phys Therapy Specialists, New Braunfels, TX USA. SW Texas State Univ, San Marcos, TX 78666 USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Univ Utah, Salt Lake City, UT USA. Intermt Hlth Care, Salt Lake City, UT USA. RP Whitman, JM (reprint author), Regis Univ, Dept Phys Therapy, 3333 Regis Blvd,G-4, Denver, CO 80221 USA. EM jwhitman@regis.edu NR 43 TC 75 Z9 76 U1 3 U2 26 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 15 PY 2006 VL 31 IS 22 BP 2541 EP 2549 DI 10.1097/01.brs.0000241136.98159.8c PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 098KK UT WOS:000241519200006 PM 17047542 ER PT J AU Inouye, LS Lotufo, GR AF Inouye, Laura S. Lotufo, Guiherme R. TI Comparison of macro-gravimetric and micro-colorimetric lipid determination methods SO TALANTA LA English DT Article DE lipid analysis; Van Handel; Bligh-Dyer; micro-method ID POLYCYCLIC AROMATIC-HYDROCARBON; LUMBRICULUS-VARIEGATUS; EXTRACTION METHODS; SEDIMENT; BLIGH; DYER AB In order to validate a method for lipid analysis of small tissue samples, the standard macro-gravimetric method of Bligh-Dyer (1959) [E.G. Bligh, W.J. Dyer, Can. J. Biochem. Physiol. 37 (1959) 911] and a modification of the micro-colorimetric assay developed by Van Handel (1985) [E. Van Handel, J. Am. Mosq. Control Assoc. I (1985) 302] were compared. No significant differences were observed for wet tissues of two species of fish. However, limited analysis of wet tissue of the amphipod, Leptocheirus plumulosus, indicated that the Bligh-Dyer gravimetric method generated higher lipid values, most likely due to the inclusion of non-lipid materials. Additionally, significant differences between the methods were observed with dry tissues, with the micro-colorimetric method consistently reporting calculated lipid values greater than as reported by the gravimetric method. This was most likely due to poor extraction of dry tissue in the standard Bligh-Dyer method, as no significant differences were found when analyzing a single composite extract. The data presented supports the conclusion that the micro-colorimetric method described in this paper is accurate, rapid, and minimizes time and solvent use. (c) 2006 Elsevier B.V. All rights reserved. C1 USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Inouye, LS (reprint author), USA, Ctr Res Dev & Engn, EP-R,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM laura.s.inouye@erdc.usace.army.mil NR 13 TC 20 Z9 23 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD OCT 15 PY 2006 VL 70 IS 3 BP 584 EP 587 DI 10.1016/j.talanta.2006.01.024 PG 4 WC Chemistry, Analytical SC Chemistry GA 091YG UT WOS:000241063600017 PM 18970812 ER PT J AU Hoff, RH Czyryca, PG Sun, MH Leyh, TS Hengge, AC AF Hoff, Richard H. Czyryca, Przemyslaw G. Sun, Meihao Leyh, Thomas S. Hengge, Alvan C. TI Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID CRYSTAL-STRUCTURE; SULFATE ESTERS; HYDROLYSIS; NITROPHENYL; PHOSPHORYL; SUBSTRATE; MECHANISM AB Kinetic isotope effects have been measured for the estrogen sulfotransferase-catalyzed sulfuryl (SO3) transfer from p-nitrophenyl sulfate to the 5'-phosphoryl group of 3'-phosphoadenosine 5'-phosphate. (18)(V/K)(nonbridge) = 1.0016 +/- 0.0005, (18)(V/K) bridge = 1.0280 +/- 0.0006, and 15(V/K) = 1.0014 +/- 0.0004. ((15)(V/K) refers to the nitro group in p-nitrophenyl sulfate). The kinetic isotope effects indicate substantial S - O bond fission in the transition state, with partial charge neutralization of the leaving group. The small kinetic isotope effect in the nonbridging sulfuryl oxygen atoms suggests no significant change in bond orders of these atoms occurs, consistent with modest nucleophilic involvement. A comparison of the data for enzymatic and uncatalyzed sulfuryl transfer reactions suggests that both proceed through very similar transition states. C1 Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA. RP Leyh, TS (reprint author), Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. EM leyh@aecom.yu.edu; hengge@cc.usu.edu RI Hengge, Alvan/C-8667-2011 OI Hengge, Alvan/0000-0002-5696-2087 FU NIGMS NIH HHS [GM47297, GM054469, GM056248, R01 GM047297] NR 27 TC 12 Z9 12 U1 1 U2 5 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 13 PY 2006 VL 281 IS 41 BP 30645 EP 30649 DI 10.1074/jbc.M604205200 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 092CZ UT WOS:000241075900040 PM 16899461 ER PT J AU Banks, HD AF Banks, Harold D. TI The profound effect of fluorine substitution on the reactivity and regioselectivity of nucleophilic substitution reactions of strained heterocycles. A study of aziridine and its derivatives SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Review ID DENSITY-FUNCTIONAL THEORY; EXPERIMENTAL CHARGE-DENSITY; AB-INITIO CALCULATIONS; GAS-PHASE; CYCLOADDITION REACTIONS; PERMANGANATE OXIDATION; ATOMIC CHARGES; HYDROGEN-BOND; MECHANISM; STEREOSELECTIVITY AB Unlike the synthetically exploited oxiranes and thiiranes, aziridines that lack electron-withdrawing substituents, such as acyl or sulfonyl functionalities at nitrogen, are rather unreactive. As expected, three-membered aziridine 6 was calculated to be significantly more reactive than azetidine 7 in nucleophilic cleavage by ammonia, a typical nucleophile. The reactivity of 7 was about the same as that of an acyclic model compound, 8, when release of ring strain in the transition state was taken into account. Fluorine due to its similar size but vastly different electronegativity has been substituted for hydrogen as a means of modifying chemical properties for varied applications. In the present investigation, the effect of fluorine substitution at aziridine positions other than nitrogen was studied. Computations at the MP2(Full)/6-311++G(d, p)//MP2(Full)/6-31+G(d) level found a vast preference for attack by ammonia at the 3-position of 2-fluoroaziridine in the gas phase at 298 K. When release of ring strain was taken into account, this compound reacted more than 10(11) times faster than 6. The reaction rate with trans-2,3-difluoroaziridine was about twice that of 2-fluoroaziridine, while its diastereomer reacted with ammonia considerably slower. Acyclic fluorinated amine model compounds were employed to assess the generality of the effects produced by fluorine substitution. The results were rationalized by the energy contributions of strain energy releases, stabilization of the leaving group, and the relative electrostatic energies of the heterocycles in the transition states. The more reactive fluoroaziridines underwent nucleophilic attack at rates comparable to those of N-acetylaziridine. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 121 TC 23 Z9 23 U1 3 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD OCT 13 PY 2006 VL 71 IS 21 BP 8089 EP 8097 DI 10.1021/jo061255j PG 9 WC Chemistry, Organic SC Chemistry GA 091UE UT WOS:000241053000019 PM 17025297 ER PT J AU Doney, R Sen, S AF Doney, Robert Sen, Surajit TI Decorated, tapered, and highly nonlinear granular chain SO PHYSICAL REVIEW LETTERS LA English DT Article AB It has been seen that inertial mismatches in 1D granular chains lead to remarkable energy absorption which increases with the number of spheres, N, and tapering, q. Short chains, however, are limited in that regard, and we therefore present one solution which greatly improves performance for any size chain. These strongly nonlinear and scalable systems feature surprisingly complicated dynamics and are inadequately represented by a hard-sphere approximation. Additionally, such systems have shock absorption capacities that vary as a function of position along the chain. In this Letter, we present results in the form of normalized kinetic energy diagrams to illustrate the impressive mitigation capability of both original and improved tapered chains. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA. RP Doney, R (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM bdoney@arl.army.mil; sen@dynamics.physics.buffalo.edu NR 21 TC 83 Z9 83 U1 0 U2 7 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD OCT 13 PY 2006 VL 97 IS 15 AR 155502 DI 10.1103/PhysRevLett.97.155502 PG 4 WC Physics, Multidisciplinary SC Physics GA 094OB UT WOS:000241247700035 PM 17155334 ER PT J AU Spanggord, RJ Sun, M Lim, P Ellis, WY AF Spanggord, Ronald J. Sun, Meg Lim, Peter Ellis, William Y. TI Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS LA English DT Article DE squalene; anthrax vaccines; Gulf War syndrome; reverse-phase liquid chromatography; method validation; detection limits AB Specific lots of anthrax vaccine adsorbed administered to members of the U.S. Armed Forces have been alleged to contain squalene, a chemical purported to be associated with illnesses of Gulf War veterans. A method of enhanced sensitivity for determining squalene in anthrax vaccine adsorbed using high-performance liquid chromatography with photodiode array detection has been developed, validated, and applied to 44 bottles of 38 lots of anthrax vaccine. In 43 bottles of 37 lots, no squalene was detected within a detection limit of 1 ng/0.5 ml dose (2 parts-per-billion). One lot, FAV008, was found to contain trace amounts of squalene at 7, 9, and 1 mu g l(-1), levels considerably below nomial human plasma levels (290 mu g l(-1)). The overall results of this investigation provide direct evidence for the absence of squalene in nearly all of anthrax vaccine preparations tested. (c) 2006 Elsevier B.V. All rights reserved. C1 SRI Int, Menlo Pk, CA 94025 USA. Walter Reed Army Inst Res, Washington, DC USA. RP Spanggord, RJ (reprint author), SRI Int, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. EM ronald.spanggord@sri.com NR 9 TC 5 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0731-7085 J9 J PHARMACEUT BIOMED JI J. Pharm. Biomed. Anal. PD OCT 11 PY 2006 VL 42 IS 4 BP 494 EP 499 DI 10.1016/j.jpba.2006.04.009 PG 6 WC Chemistry, Analytical; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 092VR UT WOS:000241125900013 PM 16762524 ER PT J AU Ugolini, C Nepal, N Lin, JY Jiang, HX Zavada, JM AF Ugolini, C. Nepal, N. Lin, J. Y. Jiang, H. X. Zavada, J. M. TI Erbium-doped GaN epilayers synthesized by metal-organic chemical vapor deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID ER-IMPLANTED GAN; PHOTOLUMINESCENCE; ELECTROLUMINESCENCE; SEMICONDUCTORS; LUMINESCENCE; DIODES; EXCITATION; ALN AB The authors report on the synthesis of Er-doped GaN epilayers by in situ doping by metal-organic chemical vapor deposition (MOCVD). The optical and electrical properties of the Er-doped GaN epilayers were studied by photoluminescence (PL) spectroscopy and van der Pauw-Hall method. Both above and below band gap excitation results in a sharp PL emission peak at 1.54 mu m. In contrary to other growth methods, MOCVD grown Er-doped GaN epilayers exhibit virtually no visible emission lines. A small thermal quenching effect, with only a 20% decrease in the integrated intensity of the 1.54 mu m PL emission, occurred between 10 and 300 K. It was found that Er incorporation has very little effect on the electrical conductivity of the GaN epilayers and Er-doped layers retain similar electrical properties as those of undoped GaN. (c) 2006 American Institute of Physics. C1 Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Ugolini, C (reprint author), Kansas State Univ, Dept Phys, Cardwell Hall, Manhattan, KS 66506 USA. EM jiang@phys.ksu.edu RI Lin, Jingyu/A-7276-2011; Jiang, Hongxing/F-3635-2011 OI Lin, Jingyu/0000-0003-1705-2635; Jiang, Hongxing/0000-0001-9892-4292 NR 19 TC 38 Z9 38 U1 0 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 9 PY 2006 VL 89 IS 15 AR 151903 DI 10.1063/1.2361196 PG 3 WC Physics, Applied SC Physics GA 094OD UT WOS:000241247900029 ER PT J AU Zavada, JM Nepal, N Lin, JY Jiang, HX Brown, E Hommerich, U Hite, J Thaler, GT Abernathy, CR Pearton, SJ Gwilliam, R AF Zavada, J. M. Nepal, N. Lin, J. Y. Jiang, H. X. Brown, E. Hommerich, U. Hite, J. Thaler, G. T. Abernathy, C. R. Pearton, S. J. Gwilliam, R. TI Ultraviolet photoluminescence from Gd-implanted AlN epilayers SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; EARTH-DOPED GAN; ELECTROLUMINESCENT DEVICES; VISIBLE EMISSION; THIN-FILMS; LUMINESCENCE; ERBIUM; SEMICONDUCTORS; EU; CATHODOLUMINESCENCE AB Deep ultraviolet emission from gadolinium (Gd)-implanted AlN thin films has been observed using photoluminescence (PL) spectroscopy. The AlN epilayers were ion implanted with Gd to a total dose of similar to 6x10(14) cm(-2). Using the output at 197 nm from a quadrupled Ti:sapphire laser, narrow PL emission was observed at 318 nm, characteristic of the trivalent Gd ion. A broader emission band, also centered at 318 nm, was measured with excitation at 263 nm. The PL emission intensity decreased by less than a factor of 3 over the sample temperature range of 10-300 K and decay transients were of the order of nanoseconds. (c) 2006 American Institute of Physics. C1 USA, Res Off, Durham, NC 27709 USA. Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA. Hampton Univ, Dept Phys, Hampton, VA 23668 USA. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Surrey, Surrey Ion Beam Ctr, Guildford GU2 7XH, Surrey, England. RP Zavada, JM (reprint author), USA, Res Off, Durham, NC 27709 USA. EM john.zavada@us.army.mil RI Lin, Jingyu/A-7276-2011; Jiang, Hongxing/F-3635-2011; Hite, Jennifer/L-5637-2015; OI Lin, Jingyu/0000-0003-1705-2635; Jiang, Hongxing/0000-0001-9892-4292; Hite, Jennifer/0000-0002-4090-0826; gwilliam, russell/0000-0002-1488-755X NR 29 TC 33 Z9 33 U1 1 U2 11 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 9 PY 2006 VL 89 IS 15 AR 152107 DI 10.1063/1.2357552 PG 3 WC Physics, Applied SC Physics GA 094OD UT WOS:000241247900056 ER PT J AU Zheng, JY Desbat, B Rastogi, VK Shah, SS DeFrank, JJ Leblanc, RM AF Zheng, Jiayin Desbat, Bernard Rastogi, Vipin K. Shah, Saumil S. DeFrank, Joseph J. Leblanc, Roger M. TI Organophosphorus hydrolase at the air-water interface: Secondary structure and interaction with paraoxon SO BIOMACROMOLECULES LA English DT Article ID TRANSFORM INFRARED-SPECTROSCOPY; LANGMUIR-BLODGETT-FILM; FT-IR SPECTROSCOPY; AIR/WATER INTERFACE; PSEUDOMONAS-DIMINUTA; SURFACE-CHEMISTRY; ANCHORED PROTEIN; QUANTUM DOTS; IN-SITU; MONOLAYERS AB The secondary structure of organophosphorus hydrolase (OPH) at the air-water interface was studied using polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS). The shape and position of the amide I and amide II bands were used to estimate the surface conformation and orientation of OPH. The PM-IRRAS results indicated that the enzyme did not unfold for the range of surface pressure used (0-30 mN/m). At low surface pressures, the signal of amide I was very weak and the intensity was almost the same as amide II. Upon further compression, the PM-IRRAS signal and the ratio of the intensity of amide I and amide II both increase, implying an increased interfacial concentration of the enzyme. From the amide I/amide II ratio and the band position, it was deduced that the enzyme adopts a conformation which gives a higher occupied surface at low surface pressure and rotates to a more vertical orientation at high surface pressures. The compression and decompression of the OPH monolayer indicated that the fingerprint of the secondary structure at the air-water interface was reversible. PM-IRRAS was also used to investigate the pH effect of the subphase on the secondary structure of OPH. The secondary structure of OPH at the air-water interface was well defined when the pH of the subphase was near its isoelectric point (IP, pH 7.6). However, it adopted a different orientation when the subphase pH values were higher or lower than the IP with formation of random coil structure. The hydrolysis of organophosphorus compound paraoxon by OPH was also studied at the air-water interface by PM-IRRAS. The pH effect and the interaction with paraoxon both seem to orientate the enzyme more in the plane of the interface and to produce random coil structure. C1 Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. Univ Bordeaux 1, Lab Physicochim Mol, UMR 5803, F-33405 Talence, France. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. EM rml@miami.edu NR 33 TC 5 Z9 5 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD OCT 9 PY 2006 VL 7 IS 10 BP 2806 EP 2810 DI 10.1021/bm060352j PG 5 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 092OG UT WOS:000241106600016 PM 17025356 ER PT J AU Bourne, NK Green, WH Dandekar, DP AF Bourne, N. K. Green, W. H. Dandekar, D. P. TI On the one-dimensional recovery and microstructural evaluation of shocked alumina SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article DE recovery; ceramic; shock wave; Hugoniot elastic limit ID DYNAMIC YIELD; STRENGTHS; COPPER; AL2O3 AB A technique has been developed in the previous work for determining dislocation interaction mechanisms in metals by shocking, unloading, then decelerating and catching part of the target for subsequent examination. This proceeds by using a system of partial momentum traps around the sample. This technique is further refined here, and is then applied to recover brittle targets that, in three-dimensional loading, would fail into a series of fragments. A number of hydrocode design simulations are presented to illustrate the technique, and the results of the experiments are presented. Sectioned targets indicate fracture, and X-ray tomography gives an overview of the volumetric damage. The response of the alumina above and below the elastic limit is highlighted. C1 Univ Manchester, Manchester M60 1QD, Lancs, England. Army Res Lab, Aberdeen Proving Ground, MD 21010 USA. RP Bourne, NK (reprint author), Univ Manchester, POB 88,Sackville St, Manchester M60 1QD, Lancs, England. EM neil.bourne@mac.com RI Bourne, Neil/A-7544-2008 NR 26 TC 16 Z9 16 U1 1 U2 2 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-5021 J9 P ROY SOC A-MATH PHY JI Proc. R. Soc. A-Math. Phys. Eng. Sci. PD OCT 8 PY 2006 VL 462 IS 2074 BP 3197 EP 3212 DI 10.1098/rspa.2006.1713 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 092OO UT WOS:000241107400018 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, S. S. Xu, K. Jow, T. R. TI Study of the charging process of a LiCoO(2)-based Li-ion battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Li-ion battery; charging; LiCoO(2); high rate; low temperature ID HIGH-POWER; SYSTEMS AB A three-electrode Li-ion cell with metallic lithium as the reference electrode was designed to study the charging process of Li-ion cells. The cell was connected to three independent testing channels, of which two channels shared the same lithium reference to measure the potentials of anode and cathode, respectively. A graphite/LiCoO(2) cell with a C/A ratio, i.e., the reversible capacity ratio of the cathode to anode, of 0.985 was assembled and cycled using a normal constant-current/constant-voltage (CC/CV) charging procedure, during which the potentials of the anode and cathode were recorded. The results showed that lithium plating occurred under most of the charging conditions, especially at high currents and at low temperatures. Even in the region of CC charging, the potential of the graphite might drop below 0 V versus Li(+)/Li. As a result, lithium plating and re-intercalating of the plated lithium into the graphite coexist, which resulted in a low charging capacity. When the current exceeded a certain level (0.4C in the present case), increasing the current could not shorten the charging time significantly, instead it aggravated lithium plating and prolonged the CV charging time. In addition, we found that lowering the battery temperature significantly aggravated lithium plating. At -20 degrees C, for example, the CC charging became impossible and lithium plating accompanied the entire charging process. For an improved charging performance, an optimized C/A ratio of 0.85-0.90 is proposed for the graphite/LiCoO(2) Li-ion cell. A high C/A ratio results in lithium plating onto the anode, while a low ratio results in overcharge of the cathode. (c) 2006 Elsevier B.V. All rights reserved. C1 USA, Res Lab, AMSRD, ARL,SE,DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD, ARL,SE,DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 13 TC 94 Z9 96 U1 13 U2 83 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT 6 PY 2006 VL 160 IS 2 SI SI BP 1349 EP 1354 DI 10.1016/j.jpowsour.2006.02.087 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 096YA UT WOS:000241411600076 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, S. S. Xu, K. Jow, T. R. TI Charge and discharge characteristics of a commercial LiCoO(2)-based 18650 Li-ion battery SO JOURNAL OF POWER SOURCES LA English DT Article DE 18650 Li-ion battery; charge; discharge; constant power; impedance; low temperature ID LI-ION CELLS; CAPACITY FADE; HIGH-POWER; ELECTROCHEMICAL IMPEDANCE; LOW-TEMPERATURES; PERFORMANCE; ELECTRODES AB We studied the charge and discharge characteristics of commercial LiCoO(2)-based 18650 cells by using various electrochemical methods, including discharging at constant power, ac impedance spectroscopy, and de-voltage pulse. At 20 degrees C, these cells deliver 8.7-6.8 Wh of energy when discharged at a power range of 1-12 W between 2.5 and 4.2 V. Ragone plots show that the effect of discharge power on the energy is significantly increased with decreasing of the temperature. For example, energy of the cell is entirely lost when the temperature downs to -10 degrees C and the discharge rate still remains at 10W. Impedance analyses indicate that the total cell resistance (R(cell)) is mainly contributed by the bulk resistance (R(b), including electric contact resistance and electrolytic ionic conductivity), solid electrolyte interface resistance (R(sei)), and charge-transfer resistance (R(ct)). Individual contribution of these three resistances to the cell resistance is greatly varied with the temperature. Near room temperature, the R(b) occupies up to half of the cell resistance, which means that the rate performance of the cell could be improved by modifying cell design such as employing electrolyte with higher ionic conductivity and enhancing electric contact of the active material particles. At low temperature, the R(ct), which is believed to reflect cell reaction kinetics, dominates the cell resistance. In addition, galvanosatic cycling tests indicate that the charge and discharge processes have nearly same kinetics. The performance discrepancy observed during charging and discharging, especially at low temperatures, can be attributed to these two factors of: (1) substantially higher R(ct) at the discharged state than at the charged state; (2) asymmetric voltage limits pre-determined for the charge and discharge processes. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 28 TC 45 Z9 48 U1 7 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT 6 PY 2006 VL 160 IS 2 SI SI BP 1403 EP 1409 DI 10.1016/j.jpowsour.2006.03.037 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 096YA UT WOS:000241411600085 ER PT J AU Happi, CT Gbotosho, GO Folarin, OA Milner, D Sarr, O Sowunmi, A Kyle, DE Milhous, WK Wirth, DF Oduola, AMJ AF Happi, Christian T. Gbotosho, Grace O. Folarin, Onikepe A. Milner, Danny Sarr, Ousmane Sowunmi, Akintunde Kyle, Dennis E. Milhous, Wilbur K. Wirth, Dyann F. Oduola, Ayoade M. J. TI Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa SO MALARIA JOURNAL LA English DT Article ID CYTOCHROME BC(1) COMPLEX; IN-VITRO; CONFERRING MUTATIONS; MALARIA PROPHYLAXIS; B GENE; BINDING; DRUG; VIVO; HYDROCHLORIDE; PYRIMETHAMINE AB Background: In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b ( cytb) gene ( Tyr268Ser and Tyr268Asn). However, little is known about the prevalence of codon- 268 mutations in natural populations of P. falciparum without previous exposure to the drug in Africa. Methods: The prevalence of codon- 268 mutations in the cytb gene of African P. falciparum isolates from Nigeria, Malawi and Senegal, where atovaquone- proguanil has not been introduced for treatment of malaria was assessed. Genotyping of the cytb gene in isolates of P. falciparum was performed by PCR-restriction fragment length polymorphism and confirmed by sequencing. Results: 295 samples from Nigeria ( 111), Malawi ( 91) and Senegal ( 93) were successfully analyzed for detection of either mutant Tyr268Ser or Tyr268Asn. No case of Ser268 or Asn268 was detected in cytb gene of parasites from Malawi or Senegal. However, Asn268 was detected in five out of 111 ( 4.5%) unexposed P. falciparum isolates from Nigeria. In addition, one out of these five mutant Asn268 isolates showed an additional cytb mutation leading to a Pro266Thr substitution inside the ubiquinone reduction site. Conclusion: No Tyr268Ser mutation is found in cytb of P. falciparum isolates from Nigeria, Malawi or Senegal. This study reports for the first time cytb Tyr268Asn mutation in unexposed P. falciparum isolates from Nigeria. The emergence in Africa of P. falciparum isolates with cytb Tyr268Asn mutation is a matter of serious concern. Continuous monitoring of atovaquone- proguanil resistant P. falciparum in Africa is warranted for the rational use of this new antimalarial drug, especially in non- immune travelers. C1 Univ Ibadan, Coll Med, Inst Adv Med Res & Training, Malaria Res Labs, Ibadan, Nigeria. Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. Dantec Hosp, Lab Bacteriol & Virol, Dakar, Senegal. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. WHO, TDR, Special Programme Res & Training Trop Dis, CH-1211 Geneva, Switzerland. RP Happi, CT (reprint author), Univ Ibadan, Coll Med, Inst Adv Med Res & Training, Malaria Res Labs, Ibadan, Nigeria. EM chappi@hsph.harvard.edu; solagbotosho@yahoo.co.uk; onikepefolarin@yahoo.com; dmilner@hsph.harvard.edu; osarr@hsph.harvard.edu; asowunmi@hotmail.com; dennis.kyle@us.army.mil; wilbur.milhous@us.army.mil; dfwirth@hsph.harvard.edu; oduolaa@who.int FU FIC NIH HHS [TW01503-0, D43 TW001503, R03TW006298-01A1, R03 TW006298] NR 36 TC 15 Z9 16 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 4 PY 2006 VL 5 AR 82 DI 10.1186/1475-2875-5-82 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 093RR UT WOS:000241186900002 PM 17020611 ER PT J AU Kim, J Roberts, GW Kiserow, DJ AF Kim, Jaehoon Roberts, George W. Kiserow, Douglas J. TI Supported Pd catalyst preparation using liquid carbon dioxide SO CHEMISTRY OF MATERIALS LA English DT Article ID SUPERCRITICAL-FLUID ROUTE; AEROGEL NANOCOMPOSITES; METAL NANOPARTICLES; FUEL-CELLS; DEPOSITION; NANOTUBES; ELECTROCATALYSTS C1 N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27606 USA. USA, Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA. RP Roberts, GW (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27606 USA. EM groberts@eos.ncsu.edu RI Kim, Jaehoon/G-6116-2014 OI Kim, Jaehoon/0000-0001-6188-7571 NR 18 TC 16 Z9 18 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD OCT 3 PY 2006 VL 18 IS 20 BP 4710 EP 4712 DI 10.1021/cm061440d PG 3 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 087PK UT WOS:000240754100002 ER PT J AU Simbulan-Rosenthal, CM Ray, R Benton, B Soeda, E Daher, A Anderson, D Smith, WJ Rosenthal, DS AF Simbulan-Rosenthal, Cynthia M. Ray, Radharaman Benton, Betty Soeda, Emiko Daher, Ahmad Anderson, Dana Smith, William J. Rosenthal, Dean S. TI Calmodulin mediates sulfur mustard toxicity in human keratinocytes SO TOXICOLOGY LA English DT Article DE CaM; caspase-3; SM; apoptosis; calcineurin ID MESSENGER-RNA LEVELS; CELL-DEATH; GENE-EXPRESSION; PROTEIN-KINASE; POLY(ADP-RIBOSE) POLYMERASE; TERMINAL DIFFERENTIATION; MOUSE KERATINOCYTES; MICROARRAY ANALYSIS; DNA FRAGMENTATION; PHOSPHOLIPASE-C AB Sulfur mustard (SM) causes blisters in the skin through a series of cellular changes that we are beginning to identify. We earlier demonstrated that SM toxicity is the result of induction of both death receptor and mitochondrial pathways of apoptosis in human keratinocytes (KC). Because of its importance in apoptosis in the skin, we tested whether calmodulin (CaM) mediates the mitochondrial apoptotic pathway induced by SM. Of the three human CaM genes, the predominant form expressed in KC was CaM1. RT-PCR and immunoblot analysis revealed upregulation of CaM expression following SM treatment. To delineate the potential role of CaM1 in the regulation of SM-induced apoptosis, retroviral vectors expressing CaM1 RNA in the antisense (AS) orientation were used to transduce and derive stable CaM I AS cells, which were then exposed to SM and subjected to immunoblot analysis for expression of apoptotic markers. Proteolytic activation of executioner caspases-3, -6, -7, and the upstream caspase-9, as well as caspase-mediated PARP cleavage were markedly inhibited by CaM I AS expression. CaM I AS depletion attenuated SM-induced, but not Fas-induced, proteolytic processing and activation of caspase-3. Whereas control KC exhibited a marked increase in apoptotic nuclear fragmentation after SM, CaM I AS cells exhibited normal nuclear morphology up to 48 h after SM, indicating that suppression of apoptosis in CaM I AS cells increases survival and does not shift to a necrotic death. CaM has been shown to activate the phosphatase calcineurin, which can induce apoptosis by Bad dephosphorylation. Interestingly, whereas SM-treated CaM1-depleted KC expressed the phosphorylated non-apoptotic sequestered form of Bad, Bad was present in the hypophosphorylated apoptotic form in SM-exposed control KC. To determine if pharmacological CaM inhibitors could attenuate SM-induced apoptosis via Bad dephosphorylation, KC were pretreated with the CaM-specific antagonist W-13 or its less active structural analogue W-12. Following SM exposure, KC exhibited Bad dephosphorylation, which was inhibited in the presence of W-13, but not with W-12. Consequently, W-13 but not W-12 markedly suppressed SM-induced proteolytic processing and activation of caspase-3, as well as apoptotic nuclear fragmentation. Finally, while the CaM antagonist W-13 and the calcineurin inhibitor cyclosporin A attenuated SM-induced caspase-3 activation, inhibitors for CaM-dependent protein kinase II (KN62 and KN93) did not. These results indicate that CaM, calcineurin, and Bad also play a role in SM-induced apoptosis, and may therefore be targets for therapeutic intervention to reduce SM injury. (c) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Georgetown Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC 20007 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Rosenthal, DS (reprint author), Georgetown Univ, Sch Med, Dept Biochem & Mol Biol, 3900 Reservoir Rd NW, Washington, DC 20007 USA. EM rosenthd@georgetown.edu FU NCI NIH HHS [1R01 CA100443-01A1, R01 CA100443-05, R01 CA100443] NR 92 TC 24 Z9 28 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD OCT 3 PY 2006 VL 227 IS 1-2 BP 21 EP 35 DI 10.1016/j.tox.2006.06.019 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 094SA UT WOS:000241258100003 PM 16935404 ER PT J AU Chern, GD Readinger, ED Shen, HG Wraback, M Gallinat, CS Koblmuller, G Speck, JS AF Chern, Grace D. Readinger, Eric D. Shen, Hongen Wraback, Michael Gallinat, Chad S. Koblmuller, Gregor Speck, James S. TI Excitation wavelength dependence of terahertz emission from InN and InAs SO APPLIED PHYSICS LETTERS LA English DT Article ID COMPACT FIBER LASER; INDIUM NITRIDE; BAND-GAP; RADIATION AB The authors report on the excitation wavelength dependence of terahertz emission from n-InN and bulk p-InAs pumped with femtosecond pulses tunable from 800 to 1500 nm. The terahertz amplitude, normalized to pump and probe power, from both narrow band gap semiconductors remains relatively constant over the excitation wavelength range. In addition, terahertz radiation from In- and N-face InN samples with bulk carrier concentrations ranging from 10(17) to 10(19) cm(-3) is also investigated, showing a strong dependence of terahertz emission on bulk carrier concentration. The experimental results agree well with calculations based on drift-diffusion equations incorporating momentum conservation and relaxation. (c) 2006 American Institute of Physics. C1 USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, Adelphi, MD 20783 USA. Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Chern, GD (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.chern@arl.army.mil RI Gallinat, Chad/E-7561-2010; Speck, James/H-5646-2011 NR 18 TC 60 Z9 60 U1 1 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 2 PY 2006 VL 89 IS 14 AR 141115 DI 10.1063/1.2358938 PG 3 WC Physics, Applied SC Physics GA 091VR UT WOS:000241056900015 ER PT J AU Day, JW Westphal, A Pratt, R Hyfield, E Rybczyk, J Kemp, GP Day, JN Marx, B AF Day, John W., Jr. Westphal, Anneliese Pratt, Richard Hyfield, Emily Rybczyk, John Kemp, G. Paul Day, Jason N. Marx, Brian TI Effects of long-term municipal effluent discharge on the nutrient dynamics, productivity, and benthic community structure of a tidal freshwater forested wetland in Louisiana SO ECOLOGICAL ENGINEERING LA English DT Article DE wetland wastewater treatment; forested wetlands; productivity ID MISSISSIPPI DELTA; DECOMPOSITION; SWAMP; COST AB Nutrient dynamics, net aboveground primary productivity (NPP), and benthic macroinvertebrates were measured in a Louisiana tidal, freshwater forested wetland that received secondary treated effluent for 27 years. NO3, NH4, TKN, PO4, TP concentrations were measured at treatment and control sites. TKN (2.0-4.0 mg/L), NH4-N (0.4-1.0 mg/L) and NO3-N accounted for almost 75%, 25% and less than 1% of TN, respectively PO4 (0-1-0.9 mg/L) was about 50% of TP. TN and TP were reduced by 79% and 88%, respectively, as water flowed through the wetland, which is consistent with low loading rates of 9.4 g N and 1.2 g P/m(2)/yr. Litterfall was significantly greater in the treatment site (717 g/m(2)/yr) than one of the control sites (412 g/m(2)/yr). Stem growth (302-776 g/m(2)/yr) was not statistically different among the sites. Total NPP was highest at treatment sites (1467 and 1442 g/m(2)/yr) which were statistically higher than one of the control sites (714 g/m(2)/yr). Total individuals, total species, and species richness of macroinvertebrates were greatest near the outfall and declined away from the discharge. In summary, long-term addition of secondarily treated municipal effluent resulted in a high level of nutrient retention, enhanced forest productivity; and minimal impact on benthic community structure. (c) 2006 Published by Elsevier B.V. C1 Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. Louisiana State Univ, Coastal Ecol Inst, Baton Rouge, LA 70803 USA. Louisiana State Univ, Sch Coast & Environm, Baton Rouge, LA 70803 USA. Louisiana State Univ, Hurricane Ctr, Baton Rouge, LA 70803 USA. Louisiana State Univ, Dept Expt Stat, Baton Rouge, LA 70803 USA. N Carolina Dept Transportat, Wilmington, NC 28401 USA. USACE, Regulatory Branch, Seattle, WA 98124 USA. Western Washington Univ, Dept Environm Sci, Bellingham, WA 98225 USA. RP Day, JW (reprint author), Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. EM johnday@lsu.edu NR 76 TC 22 Z9 25 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD OCT 2 PY 2006 VL 27 IS 3 BP 242 EP 257 DI 10.1016/j.ecoleng.2006.03.004 PG 16 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 092YM UT WOS:000241133700007 ER PT J AU McManus, JG Convertino, VA Cooke, WH Ludwig, DA Holcomb, JB AF McManus, John G. Convertino, Victor A. Cooke, William H. Ludwig, David A. Holcomb, John B. TI R-wave amplitude in lead II of an electrocardiograph correlates with central hypovolemia in human beings SO ACADEMIC EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Scientific Assembly of the American-College-of-Emergency-Physicians CY SEP 26-29, 2005 CL Washington, DC SP Amer Coll Emergency Phys DE hemorrhage; LBNP; R-wave amplitude; trauma ID HEART-RATE-VARIABILITY; TRAUMA TRIAGE RULE; BODY-SURFACE POTENTIALS; QRS AMPLITUDE; FIELD TRIAGE; IMPEDANCE CARDIOGRAPHY; BLOOD-VOLUME; HEMORRHAGE; HEMODIALYSIS; DIMENSIONS AB Objectives: Previous animal and human experiments have suggested that reduction in central blood volume either increases or decreases the amplitude of R waves in various electrocardiograph (ECG) leads depending on underlying pathophysiology. In this investigation, we used graded central hypovolemia in adult volunteer subjects to test the hypothesis that moderate reductions in central blood volume increases R-wave amplitude in lead II of an ECG. Methods: A four-lead ECG tracing, heart rate (HR), estimated stroke volume (SV), systolic blood pressure, diastolic blood pressure, and mean arterial pressure were measured during baseline supine rest and during progressive reductions of central blood volume to an estimated volume loss of >1,000 mL with application of lower-body negative pressure (LBNP) in 13 healthy human volunteer subjects. Results: Lower-body negative pressure resulted in a significant progressive reduction in central blood volume, as indicated by a maximal decrease of 65% in SV and maximal elevation of 56% in HR from baseline to -60 mm Hg LBNP. R-wave amplitude increased (p < 0.0001) linearly with progressive LBNP. The amalgamated correlation (R 2) between average stroke volume and average R-wave amplitude at each LBNP stage was -0.989. Conclusions: These results support our hypothesis that reduction of central blood volume in human beings is associated with increased R-wave amplitude in lead II of an ECG. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas San Antonio, San Antonio, TX 78285 USA. Med Coll Georgia, Augusta, GA 30912 USA. RP McManus, JG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 44 TC 10 Z9 10 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD OCT PY 2006 VL 13 IS 10 BP 1003 EP 1010 AR PII ISSN 1069-6563583 DI 10.1197/j.aem.2006.07.010 PG 8 WC Emergency Medicine SC Emergency Medicine GA 095NC UT WOS:000241313600001 PM 16973639 ER PT J AU Metter, DF Woolley, FR Bradley, Y Morrison, J Phillips, WT Salman, U Duffy, D Smith, R Graham, J Dodd, GD AF Metter, Darlene F. Woolley, F. Ross Bradley, Yong Morrison, John Phillips, William T. Salman, Umber Duffy, Daniel Smith, Reed Graham, Jess Dodd, Gerald D., III TI Teaching radiology resident didactics using videoconferencing: Development of a videoconferencing network to increase the efficiency of radiology resident training SO ACADEMIC RADIOLOGY LA English DT Article ID EDUCATION C1 Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA. Brooke Army Med Ctr, San Antonio, TX USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. RP Woolley, FR (reprint author), Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA. EM woolleyf@uthscsa.edu RI Phillips, William/E-8427-2010 OI Phillips, William/0000-0001-8248-7817 NR 14 TC 2 Z9 4 U1 0 U2 1 PU ASSOC UNIV RADIOLOGISTS PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523-2251 USA SN 1076-6332 J9 ACAD RADIOL JI Acad. Radiol. PD OCT PY 2006 VL 13 IS 10 BP 1276 EP 1285 DI 10.1016/j.acra.2006.06.023 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 087SJ UT WOS:000240762300014 PM 16979077 ER PT J AU Paonessa, DJ Shields, AD Howard, BC Gotkin, JL Deering, SH Hoeldtke, NJ Napolitano, PG AF Paonessa, Damian J. Shields, Andrea D. Howard, Bobby C. Gotkin, Jennifer L. Deering, Shad H. Hoeldtke, Nathan J. Napolitano, Peter G. TI 17-hydroxyprogesterone caproate reverses induced vasoconstriction of the fetoplacental arteries by the thromboxane mimetic U46619 SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 26th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 30-FEB 04, 2006 CL Miami Beach, FL SP Soc Maternal Fetal Med DE pregnancy; progesterone; placenta; placental vessels ID VIVO COTYLEDON MODEL; ANGIOTENSIN-II; PROGESTERONE AB Objective: This study was undertaken to determine whether 17-hydroxyprogesterone caproate (17P) has a vasoactive effect on fetoplacental vasculature. Study design: Two cotyledons were obtained from each of 5 placentas. Baseline perfusion was established with Hanks-based solution. One cotyledon from each pair was then infused with perfusate to which U46619 a thromboxane sympathomimetic had been added. After 30 minutes, a dose of 17P was then administered to each cotyledon. Finally, a vasoconstricting dose of angiotensin 11 was administered to each cotyledon. Perfusion pressures were recorded throughout. Statistical analysis of pressure change for a single cotyledon was performed by using a paired t test. Statistical analysis of mean perfusion pressure difference between U46619 exposed and nonexposed cotyledons was analyzed by using a students t test. Results: 17P did not significantly alter the perfusion pressure of the control cotyledon. (30.6 +/- 8.3 mm Hg vs 30.1 +/- 7.8 mm Hg P = .48). 17P administration significantly lowered the perfusion pressure of the U46619 preconstricted vessels in comparison with preadministration. (60.1 +/- 13 mm Hg vs 27.3 +/- 7.1 mm Hg P = .03). Both groups of cotyledons responded with vasoconstriction to angiotension 11 with no difference in response between groups (38.3 +/- 12 mm Hg vs 45.8 +/- 8.2 mm Hg P = .63). Conclusion: 17P reverses induced vasoconstriction by U46619 in fetoplacental arteries. (c) 2006 Mosby, Inc. All rights reserved. C1 Madigan Army Med Ctr, Div Maternal Fetal Med, Tacoma, WA 98431 USA. Tripler Army Med Ctr, Div Maternal Fetal Med, Honolulu, HI 96859 USA. RP Paonessa, DJ (reprint author), Madigan Army Med Ctr, Div Maternal Fetal Med, 9040 Fitzsimmons Ave, Tacoma, WA 98431 USA. EM dmpaonessa2000@yahoo.com OI Shields, Andrea/0000-0002-6729-503X NR 12 TC 6 Z9 6 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 2006 VL 195 IS 4 BP 1011 EP 1014 DI 10.1016/j.ajog.2006.06.041 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 092UT UT WOS:000241123500018 PM 16846582 ER PT J AU Grieger, TA Cozza, SJ Ursano, RJ Hoge, C Martinez, PE Engel, CC Wain, HJ AF Grieger, Thomas A. Cozza, Stephen J. Ursano, Robert J. Hoge, Charles Martinez, Patricia E. Engel, Charles C. Wain, Harold J. TI Posttraumatic stress disorder and depression in battle-injured soldiers SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article; Proceedings Paper CT 158th Annual Meeting of the American-Psychiatric-Association CY MAY 21-26, 2005 CL Atlanta, GA SP Amer Psychiat Assoc ID PTSD CHECKLIST; GULF-WAR; ACCIDENT VICTIMS; FEMALE VETERANS; PRIMARY-CARE; SYMPTOMS; TRAUMA; VALIDATION; VALIDITY; AFGHANISTAN AB Objective: This study examined rates, predictors, and course of probable posttraumatic stress disorder ( PTSD) and depression among seriously injured soldiers during and following hospitalization. Method: The patients were 613 U. S. soldiers hospitalized following serious combat injury. Standardized screening instruments were administered 1, 4, and 7 months following injury; 243 soldiers completed all three assessments. Cross-sectional and longitudinal analyses of risk factors were performed. PTSD was assessed with the PTSD Checklist; depression was assessed with the Patient Health Questionnaire. Combat exposure, deployment length, and severity of physical problems were also assessed. Results: At 1 month, 4.2% of the soldiers had probable PTSD and 4.4% had depression; at 4 months, 12.2% had PTSD and 8.9% had depression; at 7 months, 12.0% had PTSD and 9.3% had depression. In the longitudinal cohort, 78.8% of those positive for PTSD or depression at 7 months screened negative for both conditions at 1 month. High levels of physical problems at 1 month were significantly predictive of PTSD ( odds ratio = 9.1) and depression at 7 months ( odds ratio= 5.7) when the analysis controlled for demographic variables, combat exposure, and duration of deployment. Physical problem severity at 1 month was also associated with PTSD and depression severity at 7 months after control for 1-month PTSD and depression severity, demographic variables, combat exposure, and deployment length. Conclusions: Early severity of physical problems was strongly associated with later PTSD or depression. The majority of soldiers with PTSD or depression at 7 months did not meet criteria for either condition at 1 month. C1 Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. Walter Reed Army Inst Res, Dept Psychiat, Silver Spring, MD USA. RP Grieger, TA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, B-3074,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM tgrieger@usuhs.mil NR 30 TC 184 Z9 187 U1 8 U2 18 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD OCT PY 2006 VL 163 IS 10 BP 1777 EP 1783 DI 10.1176/appi.ajp.163.10.1777 PG 7 WC Psychiatry SC Psychiatry GA 089UN UT WOS:000240906800022 PM 17012689 ER PT J AU Ryan, JR Stoute, JA Amon, J Dunton, RF Mtalib, R Koros, J Owour, B Luckhart, S Wirtz, RA Barnwell, JW Rosenberg, R AF Ryan, Jeffrey R. Stoute, Jose A. Amon, Joseph Dunton, Raymond F. Mtalib, Ramadhan Koros, Joseph Owour, Boaz Luckhart, Shirley Wirtz, Robert A. Barnwell, John W. Rosenberg, Ronald TI Evidence for transmission of Plasmodium vivax among a Duffy antigen negative population in western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; LINKED-IMMUNOSORBENT-ASSAY; BLOOD-GROUP; CIRCUMSPOROZOITE PROTEINS; MALARIAL PARASITES; MOLECULAR BEACONS; BINDING-PROTEIN; SPOROZOITES; FALCIPARUM; SUSCEPTIBILITY AB We present evidence that a parasite with characteristics of Plasmodium vivax is being transmitted among Duffy blood group-negative inhabitants of Kenya. Thirty-two of 4,901 Anopheles gambiae and An. funestus (0.65%) collected in Nyanza Province were ELISA positive for the P. vivax circumsporozoite protein VK 247. All positives were found late in the rainy season, when An. funestus predominated, and disproportionately many were found at a single village. A P. vivax specific sequence of the SSU rRNA gene was amplified from three of six ELISA-positive mosquitoes. Erythrocytes from 31 children, including 9 microscopically diagnosed as infected with P. vivax, were negative by flow cytometry for the Fy3 or Fy6 epitopes, which indicate Duffy blood group expression. A DNA fragment specific for the C terminus of the gene for P. vivax merozoite surface protein 1 (MSP-1) was amplified from the blood of four of these children and subsequently sequenced from two. C1 Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. USA, Resp Med Unit, Nairobi, Kenya. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. RP Rosenberg, R (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, POB 2087, Ft Collins, CO 80521 USA. EM Quetzal6E@netscape.net; jose.stoute@us.army.mil; amonj@hrw.org; raymond.dunton@amedd.army.mil; sluckhart@ucdavis.edu; bew5@cdc.gov; wzb3@cdc.gov; rrosenberg@cdc.gov NR 46 TC 103 Z9 108 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2006 VL 75 IS 4 BP 575 EP 581 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 094BM UT WOS:000241214100001 PM 17038676 ER PT J AU Auliff, A Wilson, DW Russell, B Gao, Q Chen, N Anh, LN Maguire, J Bell, D O'Neil, MT Cheng, Q AF Auliff, Alyson Wilson, Danny W. Russell, Bruce Gao, Qi Chen, Nanhua Anh, Le Ngoc Maguire, Jason Bell, David O'Neil, Michael T. Cheng, Qin TI Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID THYMIDYLATE SYNTHASE GENE; PAPUA-NEW-GUINEA; DIHYDROFOLATE-REDUCTASE; SULFADOXINE-PYRIMETHAMINE; DIHYDROPTEROATE SYNTHASE; POINT MUTATIONS; IRIAN-JAYA; RESISTANCE; FALCIPARUM; MALARIA AB The increasing use of sulfadoxine-pyrimethamine (SP) for the treatment of chloroquine-resistant Plasmodium falciparum has resulted in increased reports of SP resistance of P. falciparum worldwide. Selection of SP-resistant Plasmodium vivax in areas where P. falciparum and P. vivax co-exist is not entirely clear. We examined the prevalence and extent of point mutations in pvdhfr and pvdhps in 70 P. vivax isolates from China, East Timor, Papua New Guinea (PNG), Philippines, Vanuatu, and Vietnam. Mutations in seven codon positions were found in pvdhfr, with the majority of isolates having double mutations (S58R/S117N). The greatest range of mutations was observed in the PNG and Vanuatu isolates, ranging from single to quadruple mutations (F57L/S58R/T61M/S117T). Single mutations in pvdhps were observed only in parasites with mutations in corresponding pvdhfr. Parasites with the S58R/S117N dhfr allelic type showed an MIC level for pyrimethamine and cycloguanil comparable to that previously reported, but were susceptible to WR99210. C1 Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Lexington, KY 40511 USA. Queensland Inst Med Res, Brisbane, Qld 4006, Australia. Jiangsu Inst Parasit Dis, Wuxi, Peoples R China. USN, Med Res Unit 2, Jakarta, Indonesia. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Cheng, Q (reprint author), Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Weary Dunlop Dr,Gallipoli Barracks, Lexington, KY 40511 USA. EM alyson.auliff@defence.gov.au; dwilson@wehi.edu.au; Bruce.Russell@menzies.edu.au; gaoqi54@hotmail.com; nanhua.chen@defence.gov.au; Le_Anh2001@yahoo.com.au; maguirejason@yahoo.com; belld@wpro.who.int; mike.oneil@defence.gov.au; qin.cheng@defence.gov.au RI Russell, Bruce/A-9240-2011 OI Russell, Bruce/0000-0003-2333-4348 NR 30 TC 51 Z9 52 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2006 VL 75 IS 4 BP 617 EP 621 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 094BM UT WOS:000241214100007 PM 17038682 ER PT J AU Orbulescu, J Constantine, CA Rastogi, VK Shah, SS DeFrank, JJ Leblanc, RM AF Orbulescu, Jhony Constantine, Celeste A. Rastogi, Vipin K. Shah, Saumil S. DeFrank, Joseph J. Leblanc, Roger M. TI Detection of organophosphorus compounds by covalently immobilized organophosphorus hydrolase SO ANALYTICAL CHEMISTRY LA English DT Article ID COUMARYL CROWN-ETHER; NERVE AGENTS; 3-DIMENSIONAL STRUCTURE; HOST MATERIALS; ENZYME; BIOSENSOR; PHOSPHOTRIESTERASE; PESTICIDES; BINDING; PROTEINS AB As a consequence of organophosphorus (OP) toxins posing a threat to human life globally, organophosphorus hydrolase (OPH) has become the enzyme of choice to detoxify such compounds. Organophosphorus hydrolase was covalently immobilized onto a quartz substrate for utilization in paraoxon detection. The substrate was cleaned and modified prior to chemical attachment. Each modification step was monitored by imaging ellipsometry as the thickness increased with each modification step. The chemically attached OPH was labeled with a fluorescent dye (7-isothiocyanato-4-methylcoumarin) for the detection of paraoxon in aqueous solution, ranging from 10(-9) to 10(-5) M. UV-visible spectra were also acquired for the determination of the hydrolysis product of paraoxon, namely p-nitrophenol. C1 Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. USA, Edgewood Chem Biol Ctr, Biotechnol Team, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. EM rml@miami.edu RI Orbulescu, Jhony/D-7829-2012 OI Orbulescu, Jhony/0000-0001-9408-9787 NR 52 TC 26 Z9 27 U1 1 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD OCT 1 PY 2006 VL 78 IS 19 BP 7016 EP 7021 DI 10.1021/ac061118m PG 6 WC Chemistry, Analytical SC Chemistry GA 089DY UT WOS:000240861700051 PM 17007528 ER PT J AU Adams, BD Cuniowski, P Muck, A Hunter, CJ DeLorenzo, RA AF Adams, B. D. Cuniowski, P. Muck, A. Hunter, C. J. DeLorenzo, R. A. TI Combat airway management: The REACH study (Registry of emergency airways arriving at combat hospitals) SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 15-16, 2006 CL New Orleans, LA SP Amer Coll Emergency Physicians C1 Brooke Army Med Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2006 VL 48 IS 4 SU S MA 85 BP S26 EP S27 PG 2 WC Emergency Medicine SC Emergency Medicine GA 090NQ UT WOS:000240958400086 ER PT J AU Dagrosa, RL McManus, JG Schwartz, RB AF Dagrosa, R. L. McManus, J. G., Jr. Schwartz, R. B. TI A survey of military personnel and civilians to assess individual preparedness for domestic terrorist attacks and natural disasters SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 15-16, 2006 CL New Orleans, LA SP Amer Coll Emergency Physicians C1 Brooke Army Med Ctr, San Antonio, TX USA. US Army Inst Surg Res, San Antonio, TX USA. Med Coll Georgia, Augusta, GA 30912 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2006 VL 48 IS 4 SU S MA 160 BP S50 EP S50 PG 1 WC Emergency Medicine SC Emergency Medicine GA 090NQ UT WOS:000240958400163 ER PT J AU Hartstein, BH Barry, JD AF Hartstein, B. H. Barry, J. D. TI Pain management during intravenous catheter placement using a topical skin coolant in the emergency department SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 15-16, 2006 CL New Orleans, LA SP Amer Coll Emergency Physicians C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2006 VL 48 IS 4 SU S MA 407 BP S122 EP S122 PG 1 WC Emergency Medicine SC Emergency Medicine GA 090NQ UT WOS:000240958400407 ER PT J AU Kolkebeck, TE Mehta, S AF Kolkebeck, T. E. Mehta, S. TI The focused assessment of sonography for trauma (FAST) exam in a forward-deployed combat emergency department: A prospective observational study SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 15-16, 2006 CL New Orleans, LA SP Amer Coll Emergency Physicians C1 Wilford Hall USAF Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX 78236 USA. Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2006 VL 48 IS 4 SU S MA 289 BP S87 EP S87 PG 1 WC Emergency Medicine SC Emergency Medicine GA 090NQ UT WOS:000240958400289 ER PT J AU Chan, DS Callahan, CW Hatch-Pigott, VB Lawless, A Proffitt, HL Manning, NE Schweikert, MP AF Chan, Debora S. Callahan, Charles W. Hatch-Pigott, Virginia B. Lawless, Annette Proffitt, H. Lorraine Manning, Nola E. Schweikert, Mary P. TI Concurrent use of metered-dose and dry powder inhalers by children with persistent asthma does not adversely affect spacer/inhaler technique SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE asthma; children; dry powder inhaler; metered-dose inhaler ID EDUCATION; SPACER AB BACKGROUND: Studies conducted in adults have suggested that patients who use a metered-dose inhaler/holding chamber spacer (MDI/S) and dry powder inhaler (DPI) concurrently will have poorer MDI/S technique than that of patients who use MDI/S exclusively. To our knowledge, as of August 31, 2006, no studies have been performed in pediatric patients. OBJECTIVE: To compare MDI/S technique scores of children using only MDI/S with scores of those using both MDI/S and DPIs. METHODS: The MDI/S technique of children aged 6-17 years, with persistent asthma, recruited from a general pediatric practice population for an asthma intervention study project was scored using a standardized checklist. MDI/S scores of children who were being treated with maintenance and rescue medication delivered only by MDI/S were compared with those treated with both MDI/S (rescue) and DPI (maintenance). Scores lower than 70% were considered to be inadequate. RESULTS: A total of 117 patients (73 male, 44 female), aged 9.70 +/- 3.1 years (mean +/- SD), with persistent asthma, participated in the study. There were 83 children (54 male, 29 female, age 9.4 +/- 3.2 y) in the MDI/S only group and 34 (19 male, 15 female, age 10.3 +/- 2.9 y) in the MDI/S + DPI group. In the MDI/S + DPI group, Diskus was the DPI used for 32 patients, and Turbuhaler was used by 2 children. Sixteen patients had severe persistent asthma, 80 had moderate persistent asthma, and 21 had mild persistent asthma as classified by National Heart Lung and Blood Institute guidelines. No difference in sex and age demographics existed; however, there was a difference in the distribution of asthma severity between groups (ie, no patients with mild persistent asthma in the MDI/S + DPI group; p <= 0.01). Mean score for the MDI/S only group was 86 +/- 17% and, for the MDI/S + DPI group, 90.1 +/- 12% (p = 0.15). More patients in the MDI/S group had inadequate scores (18%) compared with those in the MDI/S + DPI group (3%; p < 0.05). CONCLUSIONS: While DPI and MDI/S techniques are markedly different in several significant ways, concurrent use of these inhalers did not adversely affect MDI/S technique scores of pediatric patients with persistent asthma, compared with those using MDI/S alone. Patients in the MDI/S only group had an inadequate MDI/S score (< 70%) more often than did patients in the MDI/S + DPI group. C1 Tripler Army Med Ctr, Dept Pediat, Dept Pediat & Pediat Pulmonol, Honolulu, HI 96859 USA. RP Chan, DS (reprint author), Dept Pediat MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM debora.chan@haw.tamc.amedd.army.mil NR 13 TC 4 Z9 4 U1 0 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD OCT PY 2006 VL 40 IS 10 BP 1743 EP 1746 DI 10.1345/aph.1G306 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 092XU UT WOS:000241131800005 PM 16968822 ER PT J AU Gbotosho, GO Ogundahunsi, OA Happi, CT Kyle, DE Gerena, L Milhous, WK Sowunmi, A Oduola, AMJ Salako, LA AF Gbotosho, G. O. Ogundahunsi, O. A. Happi, C. T. Kyle, D. E. Gerena, L. Milhous, W. K. Sowunmi, A. Oduola, A. M. J. Salako, L. A. TI The effects of alpha(1)-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID HUMAN MALARIA PARASITES; PLASMA-PROTEIN BINDING; BASIC DRUGS; SULFADOXINE-PYRIMETHAMINE; IN-VITRO; ARTEMETHER; CHILDREN; INVITRO; AFRICA; DESIPRAMINE AB An in-vitro model based on the semi-automated microdilution technique has been developed for selecting compounds that might be used clinically for the reversal of chloroquine resistance. This was used initially to test the susceptibility of Plasmodium falciparum clone W2 to chloroquine (CQ). The model was then employed to investigate the effects of each of four resistance-reversing agents (verapamil, desipramine, chlorpheniramine and promethazine, at 1 mu m) on this parasite's susceptibility to CQ, with and without alpha(1)-acid glycoprotein (AGP), at a patho-physiological concentration (1.25 g/litre), in the culture medium. In the absence of AGP, each of the resistance-reversing agents reduced the median inhibitory concentrations of CQ by 82%-97%, from a baseline value of about 94 ng/ml. In the presence of AGP, however, most of the resistance-reversing agents had much less effect. There appears to be competitive interaction between CQ, the resistance-reversing agents and AGP. The binding kinetics between CQ, resistance-reversing agents, AGP and other plasma proteins will clearly need to elucidated if clinically effective resistance-reversing agents are to be selected in vitro. C1 Univ Coll Ibadan Hosp, Coll Med, Inst Adv & Med Training, Malaria Res Labs, Ibadan, Nigeria. Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria. WHO, TDR, CH-1211 Geneva 27, Switzerland. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Gbotosho, GO (reprint author), Univ Coll Ibadan Hosp, Coll Med, Inst Adv & Med Training, Malaria Res Labs, Ibadan, Nigeria. EM sgbot@skannet.com FU FIC NIH HHS [R03TW006298-01A1] NR 29 TC 3 Z9 4 U1 0 U2 0 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD OCT PY 2006 VL 100 IS 7 BP 571 EP 578 DI 10.1179/136485906X118486 PG 8 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA 091UK UT WOS:000241053600002 PM 16989682 ER PT J AU Budowle, B Schutzer, SE Burans, JP Beecher, DJ Cebula, TA Chakraborty, R Cobb, WT Fletcher, J Hale, ML Harris, RB Heitkamp, MA Keller, FP Kuske, C LeClerc, JE Marrone, BL McKenna, TS Morse, SA Rodriguez, LL Valentine, NB Yadev, J AF Budowle, Bruce Schutzer, Steven E. Burans, James P. Beecher, Douglas J. Cebula, Thomas A. Chakraborty, Ranajit Cobb, William T. Fletcher, Jacqueline Hale, Martha L. Harris, Robert B. Heitkamp, Michael A. Keller, Frederick Paul Kuske, Cheryl LeClerc, Joseph E. Marrone, Babetta L. McKenna, Thomas S. Morse, Stephen A. Rodriguez, Luis L. Valentine, Nancy B. Yadev, Jagjit TI Quality sample collection, handling, and preservation for an effective microbial forensics program SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Review ID BACILLUS-ANTHRACIS CONTAMINATION; SPECIMEN COLLECTION; CEREBROSPINAL-FLUID; QUANTITATIVE PCR; UNITED-STATES; TRANSPORT; BACTERIA; GLYCEROL; BIOTERRORISM; VIABILITY AB Science can be part of an effective investigative response to a bioterrorism event or a biocrime by providing capabilities to analyze biological and associated signatures in collected evidence. Microbial forensics, a discipline comprised of several scientific fields, is dedicated to the analysis of evidence from such criminal acts to help determine the responsible party and to exonerate the innocent (6). A partnership among a number of government agencies, academia, and the private sector has been formed to better respond to and deter potential perpetrators of bioterrorism or biocrimes. This partnership leverages our national scientific and analytical capabilities to support activities of law enforcement agencies. The Department of Homeland Security (DHS), whose mission is, in part, to respond to and to prevent acts of terrorism against the United States, has established the National Bioforensics Analysis Center (NBFAC) (4,6). The NBFAC, in partnership with the Federal Bureau of Investigation (FBI), (i) provides a state-of-the-art central laboratory for analysis of microbial forensic evidence and (ii) serves as a nexus for integrating the national resources to increase the effectiveness of law enforcement in obtaining the highest level of attribution possible in criminal cases where the weapon is a biological agent. One approach used by the NBFAC to establish a sound foundation, to foster communication, and to facilitate integration across government and other agencies is to promote independent meetings, which address specific needs and provide a forum for input from the broader scientific community, on the best scientific practices in microbial forensics (5). As part of this ongoing effort, a series of meetings sponsored by DHS were held at the Banbury Center of the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, to address specific issues for the enhancement of microbial forensic capability. One such meeting, held on 16 to 19 October 2005, focused on the collection, handling, and storage of samples. These issues had been identified at previous meetings (5, 6) as some of the most critical issues confronting a crime scene investigation and subsequent analysis of evidence. The participants represented diverse scientific entities within academia, the private sector, the national laboratories, and several federal agencies (Central Intelligence Agency, Centers for Disease Control and Prevention, DHS, FBI, Food and Drug Administration, and U.S. Department of Agriculture), some of which have been involved in evidence collection for purposes related to forensics, public health, or plant and animal health. The collection and preservation of microbial forensic evidence are paramount to efficient and successful investigation and attribution. If evidence (when available) is not collected, degrades, or is contaminated during collection, handling, transport, or storage, the downstream characterization and attribution analyses may be compromised. Retrieving sufficient quantities and maintaining the integrity of the evidence increase the chances of being able to characterize the material to obtain the highest level of attribution possible. This paper presents issues related to the practices of sample collection, handling, transportation, and storage and includes recommendations for future directions for the field of microbial forensics and people participating in it. The recommendations apply to the NBFAC, as well as to other facilities and practitioners. C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA. Fed Bur Invest, Div Labs, Quantico, VA 22135 USA. Dept Homeland Secur, Frederick, MD 21703 USA. US FDA, Laurel, MD 20708 USA. Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA. Cobb Consulting Serv, Kennewick, WA 99336 USA. Oklahoma State Univ, Dept Entomol & Plant Pathol, Stillwater, OK 74078 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Commonwealth Biotechnol Inc, Richmond, VA 23235 USA. Savannah River Natl Lab, Aiken, SC 29808 USA. Los Alamos Natl Lab, Los Alamos, NM 87545 USA. USDA ARS, FADDL, Plum Isl Anim Dis Ctr, Greenport, NY 11944 USA. Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. USDA ARS, Plum Isl Anim Dis Ctr, Foreign Anim Div Res Unit, Greenport, NY 11944 USA. Pacific NW Natl Lab, Richland, WA 99352 USA. RP Schutzer, SE (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, MSB E543,185 S Orange Ave, Newark, NJ 07103 USA. EM schutzer@umdnj.edu NR 48 TC 23 Z9 23 U1 3 U2 29 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 2006 VL 72 IS 10 BP 6431 EP 6438 DI 10.1128/AEM.01165-06 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 093LR UT WOS:000241170300001 PM 17021190 ER PT J AU Rohall, DE Ender, MG Matthews, MD AF Rohall, David E. Ender, Morten G. Matthews, Michael D. TI The effects of military affiliation, gender, and political ideology on attitudes toward the wars in Afghanistan and Iraq SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT 99th Annual Meeting of the American-Sociological-Association CY AUG 14-17, 2004 CL San Francisco, CA SP Amer Sociol Assoc DE war; attitudes; ROTC; West Point; civilians; civil-military gap ID SELF-SELECTION; US; EDUCATION; VALUES; GAP AB The United States armed-forces-and-society intersection is explored comparing attitudes toward the wars in Iraq and Afghanistan among West Point, Reserve Officers' Training Corps (ROTC), and civilian undergraduates. A survey was administered in January and February 2003 to determine if military affiliation is associated with attitudes toward sending troops into Afghanistan after the war started and Iraq before sending troops. Majorities of all students supported both war efforts, though United States Military Academy at West Point and ROTC cadets are somewhat more supportive of both wars compared to civilian students. However, most differences are explained by students' gender and political affiliation, Suggesting that differences between group. result from selection effects rather than cultural differences. The authors contend a fourth wave in civil-military affairs potentially has emerged in the immediate aftermath of 9/11 through a civil-military attitude fusion complicated by a gender-politics gap. C1 Western Illinois Univ, Dept Sociol & Anthropol, Macomb, IL 61455 USA. US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Rohall, DE (reprint author), Western Illinois Univ, Dept Sociol & Anthropol, Macomb, IL 61455 USA. EM de-rohall@wiu.edu; morten.ender@usma.edu; lm6270@usma.edu NR 21 TC 20 Z9 20 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2006 VL 33 IS 1 BP 59 EP 77 DI 10.1177/0095327X06289817 PG 19 WC Political Science; Sociology SC Government & Law; Sociology GA 135SK UT WOS:000244173100004 ER PT J AU Doan, BK Hickey, PA Lieberman, HR Fischer, JR AF Doan, Brandon K. Hickey, Patrick A. Lieberman, Harris R. Fischer, Joseph R. TI Caffeinated tube food effect on pilot performance during a 9-hour, simulated nighttime U-2 mission SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE caffeine; fatigue; U-2; sleep deprivation; cognitive performance; vigilance; encapsulation ID COGNITIVE PERFORMANCE; VISUAL VIGILANCE; MOOD; STRESS AB Introduction: Interventions to maintain performance are necessary to meet demanding mission requirements during sustained and surge aviation operations. Tube foods are the only foods that can be consumed during a U-2 mission due to the confining and encapsulating nature of required support equipment. Caffeine is a safe and effective strategy to enhance cognitive performance and is an ingredient in some tube foods. The objective of this study was to determine whether moderate doses of caffeinated tube foods would enhance performance in a simulated U-2 mission. Methods: Volunteers were 12 healthy USAF male pilots. The study used a double blind, placebo-controlled, two-factor, repeated-measures (five iterations per night) design. Caffeinated (200 mg each) or placebo tube food was consumed at 00:00 and 04:00. Dependent measures assessed included standardized tests of cognitive performance, vigilance, and mood designed to simulate the demands of a nighttime U-2 mission. Results: Statistically significant (p < 0.05) improvements in performance due to caffeine administration compared with placebo were present in all five cognitive tasks either as main effects interactions, or absence of significant degradation in the caffeine treatment condition compared with the placebo condition. A majority of sleep deprivation-induced performance decrements were attenuated by 200 mg of caffeine in tube food consumed every 4 h, and in some cases, performance was improved beyond baseline levels. Conclusions: Caffeinated tube food maintained cognitive performance representative of U-2 long-duration mission tasks at or near baseline levels for a 9-h overnight period in qualified USAF pilots. Side effects were minor and did not differ between placebo and caffeine conditions. C1 USAF Acad, Colorado Springs, CO 80840 USA. USAF, Res Lab, Brooks AFB, TX USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Gen Dynam AIS, Brooks City Base, TX USA. RP Doan, BK (reprint author), USAF Acad, 2169 Fieldhouse Dr, Colorado Springs, CO 80840 USA. EM Brandon.Doan@usafa.af.mil NR 22 TC 7 Z9 8 U1 0 U2 6 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2006 VL 77 IS 10 BP 1034 EP 1040 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 091SQ UT WOS:000241049000006 PM 17042248 ER PT J AU Morgan, CA Doran, A Steffian, G Hazlett, G Southwick, SM AF Morgan, Charles A., III Doran, Anthony Steffian, George Hazlett, Gary Southwick, Steven M. TI Stress-induced deficits in working memory and visuo-constructive abilities in special operations soldiers SO BIOLOGICAL PSYCHIATRY LA English DT Article DE cognition; dissociation; military performance; survival school; pre-frontal cortex; trauma exposure ID OSTERRIETH COMPLEX FIGURE; PREFRONTAL CORTEX; NEUROPEPTIDE-Y; UNCONTROLLABLE STRESS; DOPAMINE-RECEPTORS; DISORDER; PERFORMANCE; CORTISOL; NOREPINEPHRINE; PRODUCTIONS AB Background. Pre-clinical and clinical studies have shown acute stress may impair working memory and visuo-spatial ability. This study was designed to clarify the nature of stress-induced cognitive deficits in soldiers and how such deficits may contribute to operational or battlefield errors. Methods: One hundred eighty four Special Operations warfighters enrolled in Survival School completed pre-stress measures of dissociation and trauma exposure. Subjects were randomized to one of three assessment groups (Pre-stress, Stress, Post-stress) and were administered the Rey Ostereith Complex Figure (ROCF). All subjects completed post-stress measures of dissociation. Results: ROCF copy and recall were normal in the Pre- and Post-stress groups. ROCF copy and recall were significantly impaired in the Stress Group. Stress group ROCF copy performance was piecemeal, and ROCF recall was impaired. Symptoms of dissociation were negatively associated with ROCF recall in the Stress group. Baseline dissociation and history of traumatic stress predicted cognitive impairment during stress. Conclusions: Stress exposure impaired visuo-spatial capacity and working memory. In rats, monkeys, and humans, high dopamine and NE turnover in the PFC induce deficits in cognition and spatial working memory. Improved understanding of stress-induced cognitive deficits may assist in identification of soldiers at risk and lead to the development of better countermeasures. C1 VA Connecticut Healthcare Syst, Natl Ctr PTSD, West Haven, CT 06516 USA. Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA. USN, Fleet Aviat Specialized Operat Training Grp, Atlantic Fleet, Air Stn, Brunswick, ME USA. JFK Special Warfare Training Ctr & Sch, Ft Bragg, NC USA. RP Morgan, CA (reprint author), VA Connecticut Healthcare Syst, Natl Ctr PTSD, 116A, West Haven, CT 06516 USA. EM charles.a.morgan@yale.edu NR 44 TC 59 Z9 60 U1 5 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD OCT 1 PY 2006 VL 60 IS 7 BP 722 EP 729 DI 10.1016/j.biopsych.2006.04.021 PG 8 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 090TB UT WOS:000240973300009 PM 16934776 ER PT J AU McGlynn, KA Zhang, YW Sakoda, LC Rubertone, MV Erickson, RL Graubard, BI AF McGlynn, Katherine A. Zhang, Yawei Sakoda, Lori C. Rubertone, Mark V. Erickson, Ralph L. Graubard, Barry I. TI Maternal smoking and testicular germ cell tumors SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID RISK-FACTORS; CANCER-PATIENTS; EUROPEAN COUNTRIES; UNITED-STATES; BIRTH COHORT; YOUNG MEN; CRYPTORCHIDISM; HYPOSPADIAS; POPULATION; EXPOSURE AB Testicular germ cell tumors (TGCT) are the most common cancer among men ages 15 to 35 years in the United States. The well-established TGCT risk factors cryptorchism, prior diagnosis of TGCT, and family history of testicular cancer indicate that exposures in early life and/or in the familial setting may be critical to determining risk. Previous reports of familial clustering of lung cancer in mothers and testicular cancers in sons suggest that passive smoking in childhood may be such an exposure. To clarify the relationship of passive smoking exposure to TGCT risk, data from 754 cases and 928 controls enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Data from 1,086 mothers of the cases and controls were also examined. Overall, there was no relationship between maternal [odds ratio (OR), 1.1; 95% confidence interval (95% CI), 0.9-1.3] or paternal smoking (OR, 1.0; 95% CI, 0.8-1.3) and TGCT risk. Although living with a nonparent smoker was marginally related to risk (OR, 1.4; 95% CI, 1.0-2.1), there was no relationship with number of smokers, amount smoked, or duration of smoking. Responses from both case-control participants and mothers also revealed no relationship between either maternal smoking while pregnant or while breast-feeding. Results did not differ by TGCT histology (seminoma, nonseminoma). These results do not support the hypothesis that passive smoking, either in utero or in childhood, is related to risk of TGCT. Other early life exposures, however, may explain the familial clustering of lung cancer in mothers and TGCT in sons. C1 NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20892 USA. Yale Univ, Sch Med, New Haven, CT USA. USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP McGlynn, KA (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, EPS 7060,6120 Execut Blvd, Rockville, MD 20892 USA. EM mcglynnk@mail.nih.gov FU Intramural NIH HHS NR 50 TC 16 Z9 16 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD OCT PY 2006 VL 15 IS 10 BP 1820 EP 1824 DI 10.1158/1055-9965.EPI-06-0389 PG 5 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 099SU UT WOS:000241616800012 PM 17035387 ER PT J AU Scorpio, A Blank, TE Day, WA Chabot, DJ AF Scorpio, A. Blank, T. E. Day, W. A. Chabot, D. J. TI Anthrax vaccines: Pasteur to the present SO CELLULAR AND MOLECULAR LIFE SCIENCES LA English DT Review DE anthrax; anthracis; AVA; vaccines; Pasteur; rPA; Sterne ID GLUTAMIC ACID CAPSULE; BACILLUS-ANTHRACIS; PROTECTIVE ANTIGEN; LETHAL FACTOR; INHALATIONAL ANTHRAX; PROTEOMIC ANALYSIS; TOXIN COMPONENTS; IMMUNE-RESPONSE; COMPARATIVE EFFICACY; RECOMBINANT STRAINS AB Anthrax has been a major cause of death in grazing animals and an occasional cause of death in humans for thousands of years. Since the late 1800s there has been an exceptional international history of anthrax vaccine development. Due to animal vaccinations, the rate of infection has dropped dramatically. Anthrax vaccines have progressed from uncharacterized whole-cell vaccines in 1881, to pXO2-negative spores in the 1930s, to culture filtrates absorbed to aluminum hydroxide in 1970, and likely to recombinant protective antigen in the near future. Each of these refinements has increased safety without significant loss of efficacy. The threat of genetically engineered, antibiotic and vaccine resistant strains of Bacillus anthracis is fueling hypothesis-driven research and global techniques - including genomics, proteomics and transposon site hybridization - to facilitate the discovery of novel vaccine targets. This review highlights historical achievements and new developments in anthrax vaccine research. C1 USA, Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21701 USA. RP Chabot, DJ (reprint author), USA, Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Frederick, MD 21701 USA. EM donald.chabot@amedd.army.mil NR 143 TC 17 Z9 18 U1 4 U2 13 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1420-682X J9 CELL MOL LIFE SCI JI Cell. Mol. Life Sci. PD OCT PY 2006 VL 63 IS 19-20 BP 2237 EP 2248 DI 10.1007/s00018-006-6312-3 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 099PC UT WOS:000241606500006 PM 16964578 ER PT J AU Cheatham, JG Holley, AB Villines, TC Moores, LK Welka, SJ AF Cheatham, Joseph G. Holley, Aaron B. Villines, Todd C. Moores, Lisa K. Welka, Stephen J. TI Novel quantitative echocardiographic parameters in acute pulmonary embolism SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 91S EP 92S PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288000032 ER PT J AU Burkett, SE Bell, DG AF Burkett, Samuel E. Bell, David G. TI The effect of race/ethnic-specific reference values on physician interpretation of spirometry SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 119S EP 119S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288000128 ER PT J AU De Blasio, D Armstrong, D Oswald, S Shorr, A Helman, D Eisenhower, DD AF De Blasio, David Armstrong, David Oswald, Stephen Shorr, Andrew Helman, Donald Eisenhower, Dwight D. TI The effect of head of bed position on aspiration of gastric contents in patients receiving mechanical ventilation: A comparison of 30 vs 45 degrees SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 212S EP 212S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288001112 ER PT J AU Pamplin, JC Cuneo, B AF Pamplin, Jeremy C. Cuneo, Brian TI Acute amiodarone pulmonary toxicity in a patient with adult respiratory distress syndrome in the medical Intensive Care Unit SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 300S EP 300S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288001407 ER PT J AU Sill, JM Milkowski, D Peckham, S Jacobs, D Krivak, T AF Sill, Joshua M. Milkowski, Deborah Peckham, Steven Jacobs, Darick Krivak, Thomas TI A case of benign metastasizing leiomyomatosis after uterine arterial embolization SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 318S EP 318S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288001447 ER PT J AU Shah, A Osborn, EC Kristo, D AF Shah, Anita Osborn, Erik C. Kristo, David TI Novel diagnosis of pulmonary metastasis in recurrent respiratory papillomatosis SO CHEST LA English DT Meeting Abstract CT CHEST 2006 Conference CY OCT 21-26, 2006 CL Salt Lake City, UT C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2006 VL 130 IS 4 SU S BP 340S EP 341S PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 095DI UT WOS:000241288001497 ER PT J AU Hidalgo, M Buckner, JC Erlichman, C Pollack, MS Boni, JP Dukart, G Marshall, B Speicher, L Moore, L Rowinsky, EK AF Hidalgo, Manuel Buckner, Jan C. Erlichman, Charles Pollack, Marilyn S. Boni, Joseph P. Dukart, Gary Marshall, Bonnie Speicher, Lisa Moore, Laurence Rowinsky, Eric K. TI A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer SO CLINICAL CANCER RESEARCH LA English DT Article ID MAMMALIAN TARGET; BREAST-CANCER; GLIOBLASTOMA-MULTIFORME; ENHANCED SENSITIVITY; MONONUCLEAR-CELLS; PROSTATE-CANCER; MTOR INHIBITION; PTEN MUTATIONS; HIGH-FREQUENCY; SINGLE-AGENT AB Purpose: Patients with advanced cancer received temsirolimus (Torisel, CCl-779), a novel inhibitor of mammalian target of rapamycin, i.v. once daily for 5 days every 2 weeks to determine the maximum tolerated dose, toxicity profile, pharmacokinetics, and preliminary antitumor efficacy. Experimental Design: Doses were escalated in successive cohorts of patients using a conventional phase I clinical trial design. Samples of whole blood and plasma were collected to determine the pharmacokinetics of temsirolimus and sirolimus, its principal metabolite. Results: Sixty-three patients were treated with temsirolimus (0.75-24 mg/m(2)/d). The most common drug-related toxicities were asthenia, mucositis, nausea, and cutaneous toxicity. The maximum tolerated dose was 15 mg/m(2)/d for patients with extensive prior treatment because, in the 19 mg/m(2)/d cohort, two patients had dose-limiting toxicities (one with grade 3 vomiting, diarrhea, and asthenia and one with elevated transaminases) and three patients required dose reductions. For minimally pretreated patients, in the 24 mg/m(2)/d cohort, one patient developed a dose-limiting toxicity of grade 3 stomatitis and two patients required dose reductions, establishing 19 mg/m(2)/d as the maximum acceptable dose. Immunologic studies did not show any consistent trend toward immunosuppression. Temsirolimus exposure increased with dose in a less than proportional manner. Terminal half-life was 13 to 25 hours. Sirolimus-to-temsirolimus exposure ratios were 0.6 to 1.8. A patient with non-small cell lung cancer achieved a confirmed partial response, which lasted for 12.7 months, Three patients had unconfirmed partial responses; two patients had stable disease for >= 24 weeks. Conclusion: Temsirolimus was generally well tolerated on this intermittent schedule. Encouraging preliminary antitumor activity was observed. C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Brooke Army Med Ctr, Inst Drug Dev, Canc Therapy & Res Ctr, San Antonio, TX USA. Mayo Clin, Rochester, MN USA. Wyeth Res, Collegeville, PA USA. Wyeth Res, Cambridge, MA USA. RP Hidalgo, M (reprint author), Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, 1650 Orleans St,Room 1M89, Baltimore, MD 21231 USA. EM mhidalg1@jhmi.edu RI HIDALGO, MANUEL/I-4995-2015 OI HIDALGO, MANUEL/0000-0002-3765-3318 NR 55 TC 149 Z9 153 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD OCT 1 PY 2006 VL 12 IS 19 BP 5755 EP 5763 DI 10.1158/1078-0432.CCR-06-0118 PG 9 WC Oncology SC Oncology GA 092LL UT WOS:000241098100023 PM 17020981 ER PT J AU Wong, HK Tsokos, GC AF Wong, Henry K. Tsokos, George C. TI Fas (CD95) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase-dependent manner SO CLINICAL IMMUNOLOGY LA English DT Article DE apoptosis; T cells; NF-kappa B; signaling; transcription; crosstalk ID T-CELL PROLIFERATION; INDUCED APOPTOSIS; MEDIATED APOPTOSIS; SIGNALING PATHWAY; LYMPHOCYTES; FADD/MORT1; DEATH; PROTEINS; BLOCKS; RAS AB Apoptosis is an important mechanism in T cell regulation. Initiation of apoptosis can be activated through two signaling pathways via proteins that bind the death domain, the MAPK-JNK pathway mediated by DAXX and the caspase pathway mediated by FADD. T cell proliferation is initiated by ligation of the T cell receptor (TCR) and activation of NF-kappa B, a transcription factor that has antiapoptotic functions. These pathways however are not isolated, and potential crosstalk between elements of the apoptotic pathway and growth pathway may be essential in determining cell survival. We studied the interaction between Fas- and the TCR-initiated pathways in Jurkat T cell as these pathways lead to opposing consequences. We show that Fas activation can inhibit TCR- and PMA/ionophore-initiated activation of NF-kappa B activity. The inhibition is caspase-dependent since an inhibitor of caspase activation, DEVD, can block the suppression of NF-kappa B activity following crosslinking of Fas. Analysis of the expression of the subunits of NF-kappa B revealed that the levels of p50 remained constant, whereas the levels of p65 were markedly decreased by crosslinking of Fas. These findings suggest that the Fas-ligation-mediated suppression preferentially targets p65 protein expression as a mechanism for suppression of antiapoptotic activities of NF-kappa B during apoptosis. (c) 2006 Elsevier Inc. All rights reserved. C1 Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Wong, HK (reprint author), Henry Ford Hosp, Dept Dermatol, 1 Ford Pl,4D, Detroit, MI 48202 USA. EM hwong1@hfhs.org NR 29 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD OCT PY 2006 VL 121 IS 1 BP 47 EP 53 DI 10.1016/j.clim.2006.04.572 PG 7 WC Immunology SC Immunology GA 089RL UT WOS:000240898200007 PM 16765090 ER PT J AU Dunham, AE Akcakaya, HR Bridges, TS AF Dunham, Amy E. Akcakaya, H. Resit Bridges, Todd S. TI Using scalar models for precautionary assessments of threatened species SO CONSERVATION BIOLOGY LA English DT Article DE age structure; count-based PVA; extinction risk; matrix models; population viability analysis; threatened species ID POPULATION VIABILITY ANALYSIS; EXTINCTION; CONSERVATION; CALIFORNIA; DEMOGRAPHY; DYNAMICS; SURVIVAL; GROWTH AB Scalar population models, commonly referred to as count-based models, are based on time-series data of Population sizes and may be useful for screening-level ecological risk assessments when data for more complex models are not available. Appropriate use of such models for management purposes, however, requires understanding inherent biases that may exist in these models. Through a series of simulations, which compared predictions of risk of decline of scalar and matrix-based models, we examined whether discrepancies may arise from different dynamics displayed due to age structure and generation time. We also examined scalar and matrix-based population models of 18 real populations for potential patterns of bias in population viability estimates. In the simulation study, precautionary bias (i.e., overestimating risks of decline) of scalar models increased as a function of generation time. Models of real populations showed poor fit between scalar and matrix-based models, with scalar models predicting significantly higher risks of decline on average. The strength of this bias was not correlated with generation time, suggesting that additional sources of bias may be masking this relationship. Scalar models can be useful for screening-level assessments, which should in general be precautionary, but the potential shortfalls of these models should be considered before using them as a basis for management decisions. C1 Appl Biomath, Moscow 117333, Russia. USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Dunham, AE (reprint author), Harvard Univ, HUH, Dept Organism & Evolutionary Biol, 22 Divin Ave, Cambridge, MA 02138 USA. EM adunham@oeb.harvard.edu RI Akcakaya, H. Resit/A-7830-2008; Dunham, Amy/B-6161-2009 OI Akcakaya, H. Resit/0000-0002-8679-5929; Dunham, Amy/0000-0002-5184-3652 NR 47 TC 13 Z9 14 U1 2 U2 10 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0888-8892 J9 CONSERV BIOL JI Conserv. Biol. PD OCT PY 2006 VL 20 IS 5 BP 1499 EP 1506 DI 10.1111/j.1523-1739.2006.00474.x PG 8 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 091LY UT WOS:000241031600021 PM 17002767 ER PT J AU Ahmed, J Ward, TP Bursell, SE Aiello, LM Cavallerano, JD Vigersky, RA AF Ahmed, Jehanara Ward, Thomas P. Bursell, Sven-Eric Aiello, Lloyd M. Cavallerano, Jerry D. Vigersky, Robert A. TI The sensitivity and specificity of nonmydriatic digital stereoscopic retinal imaging in detecting diabetic retinopathy SO DIABETES CARE LA English DT Article ID MACULAR EDEMA; UNITED-STATES; PREVALENCE; CARE; TELEMEDICINE; PROGRAM; CAMERA AB OBJECTIVE - The objective of this study was to determine the sensitivity and specificity of Joslin Vision Network nonmydriatic digital stereoscopic retinal imaging (NMDSRI) as a screening tool in detecting diabetic retinopathy. RESEARCH DESIGN AND METHODS - We reviewed the records of 244 patients with diabetes who had a dilated funduscopic examination (DFE) and NMDSRI done within I year of each other at four locations in the metropolitan Washington, DC, area. The images were transmitted through a local area network to a central reading location where they were graded by a single retinal specialist. RESULTS - Images of 482 eyes from 243 patients were included in the study. Four images did not transmit, and 35% of the images were not gradable. Of the remaining 311 eyes, there was 86% agreement in the grading between NMDSRI and DFE: 227 eyes with no diabetic retinopathy and 40 eyes with diabetic retinopathy. In 46 eyes (15%) there was a disagreement between gradings made by the two techniques. NMDSRI detected diabetic retinopathy in 35 eyes reported as normal by DFE, and in the remaining II eyes, the DFE grade was one grade higher than the NMDSRI grade. Adjudicated nonconcordant examinations were within one grade. In the 76 eyes with diabetic retinopathy, retinal thickness could not be assessed in 17 (21%) eyes. When the NMDSRI result was gradable, the overall sensitivity of NMDSRI was 98% and the specificity was 100% for retinopathy within one grade of the DFE. In the limited number of eyes that had diabetic retinopathy with macular edema (six), agreement with the clinical examination was 100%. CONCLUSIONS - NMDSRI is a sensitive and specific method for the screening and diagnosis of diabetic retinopathy, which may help improve compliance with the standards of eye care for patients with diabetes. C1 Walter Reed Army Med Ctr, Serv Endocrinol, Washington, DC 20307 USA. Howard Univ Hosp, Div Endocrinol & Metab, Washington, DC USA. Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. Harvard Univ, Sch Med, Beetham Eye Inst, Joslin Diabet Ctr, Boston, MA 02115 USA. RP Vigersky, RA (reprint author), Walter Reed Army Med Ctr, Serv Endocrinol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM robert.vigersky@na.amedd.army.mil NR 21 TC 71 Z9 73 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD OCT PY 2006 VL 29 IS 10 BP 2205 EP 2209 DI 10.2337/dc06-0295 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 091FZ UT WOS:000241013600004 PM 17003294 ER PT J AU Newman, L Brigger, M Chiappetta, J AF Newman, Lisa Brigger, M. Chiappetta, J. TI Swallowing deficits in victims of blast injuries SO DYSPHAGIA LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0179-051X J9 DYSPHAGIA JI Dysphagia PD OCT PY 2006 VL 21 IS 4 BP 299 EP 299 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 128IJ UT WOS:000243651100036 ER PT J AU Bessaud, M Peyrefitte, CN Pastorino, BAM Tock, F Merle, O Colpart, JJ Dehecq, JS Girod, R Jaffar-Bandjee, MC Glass, PJ Parker, M Tolou, HJ Grandadam, M AF Bessaud, Mael Peyrefitte, Christophe N. Pastorino, Boris A. M. Tock, Fabienne Merle, Olivier Colpart, Jean-Jacques Dehecq, Jean-Sebastien Girod, Romain Jaffar-Bandjee, Marie-Christine Glass, Pamela J. Parker, Michael Tolou, Hugues J. Grandadam, Marc TI Chikungunya virus strains, Reunion Island outbreak SO EMERGING INFECTIOUS DISEASES LA English DT Letter C1 IMTSSA, Unite Virol Trop, F-13988 Marseille, France. Walter Reed Army Inst Res, Silver Spring, MD USA. Agence Biomed, Lyon, France. Direct Reg Affaires Sanit & Sociales, St Denis, Reunion. Ctr Hosp Dept Felix Guyon, St Denis, Reunion. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Grandadam, M (reprint author), IMTSSA, Unite Virol Trop, BP 46, F-13988 Marseille, France. EM publi.viro@laposte.net; publi.viro@laposte.net RI Glass, Pamela/G-1170-2011 NR 10 TC 42 Z9 46 U1 1 U2 3 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2006 VL 12 IS 10 BP 1604 EP 1606 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 089VS UT WOS:000240910200026 PM 17176585 ER PT J AU Taylor, AJ AF Taylor, Allen J. TI Evidence to support aggressive management of HDL-cholesterol: implications of recent trials SO EUROPEAN HEART JOURNAL SUPPLEMENTS LA English DT Article; Proceedings Paper CT 2nd International Merck Symposium on HDL-Cholesterol Raising - Bridging the Gap in Cardiovascular Risk Reduction CY OCT 14-15, 2005 CL Barcelona, SPAIN DE HDL-cholesterol; lipid profile; nicotinic acid; niacin; HMG-CoA reductase inhibitors; cardiovascular risk ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; SECONDARY PREVENTION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; RANDOMIZED-TRIAL; NIACIN; SIMVASTATIN; DYSLIPIDEMIA; EFFICACY AB Low HDL-cholesterol is an independent risk factor for coronary disease and its prevalence is high and increasing. Lifestyle interventions are recommended for all patients at risk of cardiovascular disease, but exercise has limited effects on HDL-cholesterol. Nicotinic acid is currently the most effective pharmacological agent available for increasing levels of HDL-cholesterol. The HDL Atherosclerosis Treatment study (HATS) showed that combining nicotinic acid with a statin improved HDL-cholesterol and LDL-cholesterol, inhibited the progression of atherosclerosis, and reduced cardiovascular event rates in a high-risk population with established coronary heart disease. A prolonged-release formulation of nicotinic acid (Niaspan(R)) has been developed that is as effective as the immediate-release version, but is better tolerated. The double-blind, randomized Arterial. Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER 2) study, and its open-label follow-up study, ARBITER 3, showed that Niaspan shares the anti-atherogenic benefits of immediate-release nicotinic acid. The Atherothrombosis Intervention in Metabolic Syndrome with Low HDL-C/High Triglyceride and Impact on Global Health Outcomes (AIM-HIGH) study will define the potential of correcting low HDL-cholesterol to improve clinical outcomes in patients with well-controlled LDL-cholesterol. In summary, the current evidence base clearly shows that aggressive intervention to correct tow HDL-cholesterol as well as high LDL-cholesterol is a proven strategy for preventing atherosclerotic cardiovascular disease. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil NR 34 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1520-765X J9 EUR HEART J SUPPL JI Eur. Heart J. Suppl. PD OCT PY 2006 VL 8 IS F BP F74 EP F80 DI 10.1093/eurheartj/sul045 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 099XU UT WOS:000241631900014 ER PT J AU Venkatesan, MM Ranallo, RT AF Venkatesan, Malabi M. Ranallo, Ryan T. TI Live-attenuated Shigella vaccines SO EXPERT REVIEW OF VACCINES LA English DT Review DE challenge studies; immunogenicity; live invasive Shigella vaccine; safety ID O-ANTIGEN MODIFICATION; ENTEROTOXIGENIC ESCHERICHIA-COLI; DELETED AROD GENE; NF-KAPPA-B; FLEXNERI 2A; IMMUNE-RESPONSES; BACILLARY DYSENTERY; CONJUGATE VACCINES; ORAL IMMUNIZATION; SERUM ANTIBODIES AB Several live-aftenuated Shigelia vaccines, with well-defined mutations in specific genes, have shown great promise in eliciting significant immune responses when given orally to volunteers. These responses have been measured by evaluating antibody-secreting cells, serum antibody levels and fecal immunoglobulin A to bacterial lipopolysaccharide and to individual bacterial invasion plasmid antigens. In this review, data collected from volunteer trials with live Shigelia vaccines from three different research groups are described. The attenuating features of the bacterial strains, as well as the immune response following the use of different dosing regimens, are also described. The responses obtained with each vaccine strain are compared with data obtained from challenge trials using wild-type Shigelia strains. Although the exact correlates of protection have not been found, some consensus may be derived as to what may constitute a protective immune response. Future directions in the field of live Shigella vaccines are also discussed. C1 Walter Reed Army Inst Res, Div Bacterial & Rickettisal Dis, Silver Spring, MD 20910 USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettisal Dis, 503 Robert Forney Dr,Room 3s12, Silver Spring, MD 20910 USA. EM malabi.venkatesan@na.amedd.army.mil NR 107 TC 38 Z9 38 U1 0 U2 1 PU FUTURE DRUGS LTD PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD OCT PY 2006 VL 5 IS 5 BP 669 EP 686 DI 10.1586/14760584.5.5.669 PG 18 WC Immunology SC Immunology GA 116NV UT WOS:000242810500016 PM 17181440 ER PT J AU Cabrera, RA Dozier, BL Duffy, DM AF Cabrera, Rafael A. Dozier, Brandy L. Duffy, Diane M. TI Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium SO FERTILITY AND STERILITY LA English DT Article DE prostaglandin; primate; ovary; ovulation; cyclooxygenase; ovarian cancer ID E-2 BIOSYNTHESIS; GRANULOSA-CELLS; OVULATION; CYCLOOXYGENASE-2; FOLLICLES; IDENTIFICATION; APOPTOSIS; CANCER; GONADOTROPIN; INHIBITOR AB Objective: To determine whether hCG regulates the expression of prostaglandin (PG) synthesis enzymes and the production of PGs by normal monkey ovarian surface epithelium (OSE). Design: Experimental animal study. Setting: Research laboratory. Animal(s): Adult cynomolgus macaques. Intervention(s): Monkeys exogenous gonadotropins to stimulate multiple follicular development. Ovarian surface epithelium cells and whole ovaries were obtained before (0 hours) and 36 hours after an ovulatory dose of hCG. Main Outcome Measure(s): Ovarian surface epithelium expression of prostaglandin endoperoxide synthase 1 (PTGS1) and PTGS2 proteins was determined by immunocytochemistry. Prostaglandin E-2 and PGF(2 alpha) production was assessed by enzyme immunoassays. Result(s): Ovarian surface epithelium maintained in long-term culture expressed mRNA and protein for PTGS1 and PTGS2 (n = 6); inhibition of PTGS1, but not PTGS2, reduced PGE(2) synthesis (n = 3). Prostaglandin endoperoxide synthase 1 was present in OSE of ovarian tissue sections obtained 0 (n = 4) and 36 (n = 3) hours after hCG: PTGS2 was not detected. Ovarian surface epithelium collected 0 (n = 3) and 36 (n = 4) hours after hCG expressed mRNAs for PRGS1, PTGS2, and three PGE synthases; the ratio of PTGS2 to PTGS1 increased in response to hCG exposure. Conclusion(s): Monkey OSE expresses mRNA for PTGS1, PTGS2, and all PGE synthases and produces PGE(2) both before and 36 hours after hCG. Detection of PTGS1, but not PTGS2, protein in OSE in vivo supports the hypothesis that PTGS1 is the enyzme responsible for PGE(2) production by primate OSE in vivo. C1 Eastern Virginia Med Sch, Jones Inst Reprod Med, Dept Obstet & Gynecol, Norfolk, VA 23501 USA. Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23501 USA. RP Cabrera, RA (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM rafael.cabrera@na.amedd.army.mil FU NICHD NIH HHS [HD39872] NR 42 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD OCT PY 2006 VL 86 SU 3 BP 1088 EP 1096 DI 10.1016/j.fertnstert.2006.03.022 PG 9 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 095DV UT WOS:000241289300008 PM 16962117 ER PT J AU Marshall, D Stuart, M Bell, R AF Marshall, David Stuart, Mark Bell, Rick TI Examining the relationship between product package colour and product selection in preschoolers SO FOOD QUALITY AND PREFERENCE LA English DT Article; Proceedings Paper CT 6th Pangborn Sensory Science Symposium CY AUG 07-11, 2005 CL Harrogate, ENGLAND DE children; colour preference; packaging ID CHILDREN; CHOICE AB colour as a variable [Leon, F., Couronne, T., Marcuz, M. C., & Koster, E. P. (1999). Measuring food liking in children: a comparison of non-verbal methods. Food Quality and Preference 10, 93-100; Lavin, J., & Lawless, H. T. (1998). Effects of color and odor on judgments of sweetness among children and adults. Food Quality and Preference 9, 283-289] but there is little work on how children react to colour in the context of packaging and product categorisation. Attractively coloured packaging may serve to influence children's selection or persuasion in the store [Hutchings, J. B. (2003). Expectations and the food industry: The impact of color and appearance. New York: Kluwer Academic/Plenum Publishers]. The main objective of the study was to determine the role of packaging colour in product selection among preschoolers, by age and gender, across three product categories: cereals, biscuits and drinks. Forty-three preschoolers, 36 girls and 7 boys, aged 3-5-years-old participated in the study. The three product categeories, with logo and brand information obscured, were presented with a range of nine colours. The children were asked to choose one package from each category for themselves, one package from each category for a boy, and one package from each category for a girl. They were then asked why they had chosen the packages and asked about their favourite colour. The results showed a high correlation between favourite colour and choice of product across the total sample, with lower correlations for individuals. Favourite colours were pink (24%), purple (11.4) yellow and blue (both 9%) and most popular colours were pink (40.9%), followed by purple (15%) and yellow (15%). Correlations were lower when selecting for boys and girls, with younger children more likely to select colours that matched their own preferences. (c) 2006 Elsevier Ltd. All rights reserved. C1 Univ Edinburgh, Sch Management, Edinburgh EH8 9JY, Midlothian, Scotland. USA, Natrick RD&E Ctr, Natick, MA 01760 USA. RP Marshall, D (reprint author), Univ Edinburgh, Sch Management, Edinburgh EH8 9JY, Midlothian, Scotland. EM d.w.marshall@ed.ac.uk NR 24 TC 24 Z9 24 U1 1 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD OCT-DEC PY 2006 VL 17 IS 7-8 BP 615 EP 621 DI 10.1016/j.foodqual.2006.05.007 PG 7 WC Food Science & Technology SC Food Science & Technology GA 083AU UT WOS:000240429100012 ER PT J AU Kim, DH Berkowitz, MJ AF Kim, David Hakbum Berkowitz, Mark Jacob TI Congenital variation of the peroneus longus and brevis muscle-tendon units in association with peroneus quartus: A case report SO FOOT & ANKLE INTERNATIONAL LA English DT Article C1 Colorado Permanente Med Grp, Dept Orthopaed Surg, Denver, CO USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kim, DH (reprint author), Univ Colorado, Sch Med, 2045 Franklin St, Denver, CO 80205 USA. EM david.h.kim@kp.org NR 4 TC 6 Z9 7 U1 0 U2 0 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD OCT PY 2006 VL 27 IS 10 BP 847 EP 848 PG 2 WC Orthopedics SC Orthopedics GA 093AZ UT WOS:000241140900017 PM 17054889 ER PT J AU Lee, DH Cash, BD Womeldorph, CM Horwhat, JD AF Lee, Dong H. Cash, Brooks D. Womeldorph, Craig M. Horwhat, John D. TI Endoscopic therapy of a splenic abscess: definitive treatment via EUS-guided transgastric drainage SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID PANCREATIC-DUCT DRAINAGE AB Background: Splenic complications of pancreatitis are exceedingly rare, occurring in only 2.2% of cases. Patients typically present in a dramatic fashion and often need an urgent procedure to prevent overwhelming infection or hemorrhage. Historically, the procedures involve surgery (distal pancreatectomy and splenectomy) or percutaneous drainage. Setting: Walter Reed Army Medical Center. Patient: A patient with acute or chronic pancreatitis presented with pleuritic chest pain and fever up to 105 degrees F (40.6 degrees C). A CT of the abdomen and the pelvis demonstrated a splenic abscess. Intervention: Because of the technical inability to perform transpapillary drainage, EUS-guided transgastric drainage resolved the splenic abscess. Conclusions: This is the first reported case of a splenic abscess treated definitively with endoscopic therapy. In the face of a worsening clinical picture and reported morbidities up to 79% with surgical and percutaneous drainage procedures, endoscopic therapies should be considered in the management of splenic complications of pancreatitis. C1 Uniformed Serv Univ Hlth Sci, Dept Gastroenterol, Natl Naval Med Ctr, Walter Reed Army Med Ctr,Dept Gastroenterol, Bethesda, MD 20889 USA. RP Lee, DH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Gastroenterol, Natl Naval Med Ctr, Walter Reed Army Med Ctr,Dept Gastroenterol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 8 TC 17 Z9 19 U1 1 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD OCT PY 2006 VL 64 IS 4 BP 631 EP 634 DI 10.1016/j.gie.2006.04.031 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 092ZE UT WOS:000241135800027 PM 16996360 ER PT J AU Malinowski, JC AF Malinowski, Jon C. TI War Epidemics: An historical geography of infectious diseases in military conflict and civil strife, 1850-2000. SO GEOGRAPHICAL REVIEW LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Malinowski, JC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER GEOGRAPHICAL SOC PI NEW YORK PA 120 WALL ST, STE 100, NEW YORK, NY 10005 USA SN 0016-7428 J9 GEOGR REV JI Geogr. Rev. PD OCT PY 2006 VL 96 IS 4 BP 728 EP 730 PG 3 WC Geography SC Geography GA 174BJ UT WOS:000246915900018 ER PT J AU Barrier, BF Kendall, BS Sharpe-Timms, KL Kost, ER AF Barrier, Breton F. Kendall, Brian S. Sharpe-Timms, Kathy L. Kost, Edward R. TI Characterization of human leukocyte antigen-G (HLA-G) expression in endometrial adenocarcinoma SO GYNECOLOGIC ONCOLOGY LA English DT Article DE human leukocyte antigen-G (HLA-G); endometrial adenocarcinoma; immune tolerance; clinical marker ID OVARIAN-CARCINOMA; FUNCTIONAL-ROLE; T-LYMPHOCYTES; UP-REGULATION; G MOLECULE; IFN-GAMMA; CELLS; TROPHOBLASTS; INHIBITION; ACCEPTANCE AB Objectives. The current study sought to determine if endometrial adenocarcinomas express human leukocyte antigen-G (HLA-G), an immune-regulatory protein, and if degree of expression correlates with the stage of carcinoma. Methods. Forty-four primary endometrial adenocarcinomas were tested using immunohistochemical staining with the 41484 anti-HLA-G monoclonal antibody. Metastatic implants were not included. A subset of 10 samples was tested using RNA in situ hybridization to confirm the presence of HLA-G transcript. Results of staining were analyzed with respect to grade, tumor histology, and stage of disease. Spearman rank correlation was used to assess tumor grade, histology, and disease stage as a function of HLA-G protein staining. Receiver-operator characteristic (ROC) curve analysis was used to determine the feasibility of HLA-G protein staining as a clinical marker for advanced stage disease. Results. Immunohistochemical staining for HLA-G protein was seen in 55% (24/44) of primary site endometrial adenocarcinomas and localized to glandular but not stromal epithelium. RNA in situ hybridization confirmed the presence of transcript in the majority of samples tested and also localized to glandular epithelium. A significant correlation was seen with increasing HLA-G protein staining and increasing stage of endometrial cancer, P < 0.01. HLA-G was found to be a fair discriminator as a test for metastatic disease with an area under the ROC curve of 0.75 for metastatic versus non-metastatic disease. Conclusions. HLA-G protein is expressed in a significant number of endometrial adenocarcinomas, in which it is localized to the glandular epithelium. HLA-G may serve as a clinical marker for the preoperative prediction of metastatic endometrial cancer. (c) 2006 Elsevier Inc. All rights reserved. C1 Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, MCHE OG, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, Lackland AFB, TX 78236 USA. Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. Univ Missouri, Dept Obstet Gynecol & Womens Hlth, Div Reprod & Perinatal Res, Columbia, MO 65212 USA. RP Kost, ER (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, MCHE OG, Bldg 3600,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM edward.kost@cen.amedd.army.mil NR 26 TC 40 Z9 45 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2006 VL 103 IS 1 BP 25 EP 30 DI 10.1016/j.ygyno.2006.01.045 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 089NJ UT WOS:000240887100007 PM 16530254 ER PT J AU Rojkind, M Barnaeva, E Bustamante, M Nicholson, D Rahner, C Harding, M Sojgren, MH AF Rojkind, Marcos Barnaeva, Elena Bustamante, Marcia Nicholson, Diarmud Rahner, Christoph Harding, Martha Sojgren, Maria H. TI Hepatic stellate cells sustain and/or promote differentiation of liver stem cells SO HEPATOLOGY LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 27-31, 2006 CL Boston, MA SP Amer Assoc Study Liver Dis C1 George Washington Univ, Med Ctr, Washington, DC 20037 USA. Walter Reed Army Med Ctr, Washington, DC USA. Yale Univ, Vasc Biol & Transplant, New Haven, CT USA. Yale Univ, Cellular & Mol Imaging, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2006 VL 44 IS 4 SU 1 MA 765 BP 473A EP 474A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 096FF UT WOS:000241362301306 ER PT J AU Rojkind, M Hernandez-Nazara, Z Amorim, M AF Rojkind, Marcos Hernandez-Nazara, Zmira Amorim, Marcos TI Acetaldehyde induces the nuclear to cytoplasmic translocation of Ski/Smad4 complexes and poteasomal degradation of Ski in human hepatic stellate cells SO HEPATOLOGY LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 27-31, 2006 CL Boston, MA SP Amer Assoc Study Liver Dis C1 George Washington Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2006 VL 44 IS 4 SU 1 MA 1035 BP 574A EP 574A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 096FF UT WOS:000241362302129 ER PT J AU Brown, ER Khromova, TB Globus, T Woolard, DL Jensen, JO Majewski, A AF Brown, Elliott R. Khromova, Tatyana B. Globus, Tatiana Woolard, Dwight L. Jensen, James O. Majewski, Alexander TI Terahertz-regime attenuation signatures in Bacillus subtilis and a model based on surface polariton effects SO IEEE SENSORS JOURNAL LA English DT Article DE Bacillus subtilis; ellipsoidal particle scattering; peptidoglycan; polariton; resonant polarizability; spore coat; transverse optical phonon ID MOLECULES; COAT AB A summary is provided for terahertz attenuation signatures measured in spore-laden samples of Bacillus subtilis in three different forms: 1) concentrated powder; 2) dilute powder; and 3) aerosol. In addition to a surprising spectral narrowness, some signatures also display an increase in peak signature strength (per spore) with dilution of the sample. A model is constructed to explain this phenomenology based on the presence of optical phonons and electromagnetic interaction with the spore wall. Specifically, the spheroidal Bacillus spores admit surface modes that interact with radiation via polaritonic coupling and are underdamped if isolated from each other through a dilution or aerosol levitation. Hence, the results defy longstanding assumptions that the biomolecular-related terahertz vibrations are necessarily overdamped and have immeasurably weak attenuation. C1 Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. USA, Edgewood Chem & Biol Ctr, Edgewood, MD 21010 USA. Goodrich Corp, Danbury, CT 06810 USA. Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Brown, ER (reprint author), Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. EM erbrown@ece.ucsb.edu; tbk4b@virginia.edu; dwight.woolard@us.army.mil NR 17 TC 8 Z9 8 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD OCT PY 2006 VL 6 IS 5 BP 1076 EP 1083 DI 10.1109/JSEN.2006.881354 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 086UJ UT WOS:000240698200007 ER PT J AU Ren, HA Du, Q Wang, J Chang, CI Jensen, JO Jensen, JL AF Ren, Hsuan Du, Qian Wang, Jing Chang, Chein-I Jensen, James O. Jensen, Janet L. TI Automatic target recognition for hyperspectral imagery using high-order statistics SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID PROJECTION PURSUIT; MIXTURE ANALYSIS; CLASSIFICATION AB Due to recent advances in hyperspectral imaging sensors many subtle unknown signal sources that cannot be resolved by multispectral sensors can be now uncovered for target detection, discrimination, and identification. Because the information about such sources is generally not available, automatic target recognition (ATR) presents a great challenge to hyperspectral image analysts. Many approaches developed for ATR are based on second-order statistics in the past years. This paper investigates ATR techniques using high order statistics. For ATR in hyperspectral imagery, most interesting targets usually occur with low probabilities and small population and they generally cannot be described by second-order statistics. Under such circumstances, using high-order statistics to perform target detection have been shown by experiments in this paper to be more effective than using second order statistics. In order to further address a challenging issue in determining the number of signal sources needed to be detected, a recently developed concept of virtual dimensionality (VD) is used to estimate this number. The experiments demonstrate that using high-order statistics-based techniques in conjunction with the VD to perform ATR are indeed very effective. C1 Natl Cent Univ, Ctr Space & Remote Sensing Res, Tao Yuan 320, Taiwan. Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. Univ Maryland Baltimore Cty, Remote Sensing Signal & Image Proc Lab, Baltimore, MD 21250 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Ren, HA (reprint author), Natl Cent Univ, Ctr Space & Remote Sensing Res, 300 Jhong Da Rd, Tao Yuan 320, Taiwan. EM cchang@umbc.edu NR 23 TC 30 Z9 35 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD OCT PY 2006 VL 42 IS 4 BP 1372 EP 1385 DI 10.1109/TAES.2006.314578 PG 14 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 145OP UT WOS:000244874700012 ER PT J AU Moss, CD Grzegorczyk, TM O'Neill, K Kong, JA AF Moss, Christopher D. Grzegorczyk, Tomasz M. O'Neill, Kevin Kong, Jin Au TI A hybrid time-domain model of electromagnetic induction from conducting, permeable targets SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE buried object detection; electromagnetic induction (EMI); finite-element method (FEM); method of moments (MoM) ID EXCITATION; FIELDS AB Electromagnetic induction (EMI) is a popular technique to detect and discriminate buried unexploded ordnance (UXO). However, modeling of the EMI response from many types of UXO is difficult due to the small skin depth of the interior fields. In grid-based numerical methods, meshing the target volume or surface to resolve the skin depth is often highly impractical, yet a failure to do so yields inaccurate results. This paper addresses the problem with a time-domain hybrid technique based on thin-skin approximation (TSA) that is very accurate for small skin depths. The TSA method is applied to axisymmetric problems and is shown to be both fast and accurate when the skin depth is small. The method is compared with analytical results, and excellent agreement is obtained. For magnetic materials (such as steel), the TSA method is accurate for the complete time-domain EMI response. In such cases, the TSA method provides an improved accuracy along with an order-of-magnitude reduction in CPU time compared to a dense-mesh finite-element method (FEM). For nonmagnetic materials, the TSA loses accuracy as time progresses and must be combined with a coarse-mesh FEM. In such cases, the combined method still provides greater accuracy with comparable CPU time. C1 BAE Syst, Burlington, MA 01803 USA. MIT, Cambridge, MA 02139 USA. Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Moss, CD (reprint author), BAE Syst, Burlington, MA 01803 USA. EM cmoss@alum.mit.edu NR 27 TC 4 Z9 4 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD OCT PY 2006 VL 44 IS 10 BP 2916 EP 2926 DI 10.1109/TGRS.2006.876714 PN 2 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 089LE UT WOS:000240881300008 ER PT J AU Ozbay, A Nowak, ER Edelstein, AS Fischer, GA Nordman, CA Cheng, SF AF Ozbay, Arif Nowak, E. R. Edelstein, A. S. Fischer, G. A. Nordman, C. A. Cheng, Shu Fan TI Magnetic-field dependence of the noise in a magnetoresistive sensor having MEMS flux concentrators SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 41st IEEE International Magnetics Conference (Intermag 2006) CY MAY 08-12, 2006 CL San Diego, CA SP IEEE DE field sensor; flux concentrator; magnetometer; magnetoresistance; noise ID 1/F NOISE; GMR AB We report the dc and ac magnetic field dependence of the low-frequency noise in a microelectromechanical system (MEMS) flux concentrator device containing a giant magnetoresistance spin valve (SV). The noise is dominated by resistance fluctuations having a magnetic origin. Under nominally zero magnetic-field biasing conditions, the noise power is large and varies rapidly with small changes in magnetic field. Metastability between distinct resistive states is observed and can be suppressed with the application of a moderate longitudinal field. Stationary flux concentrators do not contribute excess noise, rather the dominant source of noise is the SVs themselves. This result indicates that the device is likely to increase the sensitivity of many magnetic sensors at low frequencies by orders of magnitude. C1 Univ Delaware, Dept Phys & Astron, Newark, DE 19711 USA. USA, Res Lab, Adelphi, MD 20783 USA. NVE Corp, Eden Prairie, MN 55344 USA. USN, Res Lab, Washington, DC 20375 USA. RP Ozbay, A (reprint author), Univ Delaware, Dept Phys & Astron, Newark, DE 19711 USA. EM aozbay@udel.edu NR 11 TC 7 Z9 7 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD OCT PY 2006 VL 42 IS 10 BP 3306 EP 3308 DI 10.1109/TMAG.2006.879752 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 089NZ UT WOS:000240888700346 ER PT J AU Shkuratov, SI Talantsev, EF Baird, J Rose, MF Shotts, Z Roberts, Z Altgilbers, LL Stults, AH AF Shkuratov, Sergey I. Talantsev, Evgueni F. Baird, Jason Rose, Millard F. Shotts, Zachary Roberts, Zack Altgilbers, Larry L. Stults, Allen H. TI Completely explosive autonomous high-voltage pulsed-power system based on shockwave ferromagnetic primary power source and spiral vector inversion generator SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article; Proceedings Paper CT 15th IEEE International Pulsed Power Conference CY 2005 CL Monterey, CA SP IEEE DE direct energy conversion; explosive pulsed power; hard ferromagnets; shockwave demagnetization ID ND2FE14B HARD FERROMAGNETICS; WAVE DEMAGNETIZATION AB Novel explosive and conventional pulsed-power technologies were combined, and a series of explosive-driven high-voltage power supplies was designed, built, and tested. The power supply contained an explosive-driven high-voltage primary power source based on the fundamental physical effect of shockwave demagnetization of Nd2Fe14B high-energy ferromagnet and a power-conditioning stage. The volume of the energy-carrying ferromagnetic elements in the shockwave ferromagnetic generators (FMGs) was 8.75 cm(3). The power-conditioning stage was based on the spiral vector inversion generator (VIG). The combined FMG-VIG system demonstrated successful operation and good performance. The output-voltage pulse amplitude of the combined FMG-VIG system exceeded 40 kV, with a rise time of 6.2 ns. The methodology was developed for digital simulation of the operation of completely explosive FMG-VIG system. Experimental results obtained are in a good agreement with the results of digital calculations performed. C1 Loki Inc, Rolla, MO 65409 USA. Radiance Technol Inc, Huntsville, AL 35807 USA. USA, Space & Missile Def Command, Huntsville, AL 35807 USA. USA Aviat & Missile Res, Ctr Dev & Engn, Huntsville, AL 35898 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65409 USA. OI Talantsev, Evgeny/0000-0001-8970-7982 NR 22 TC 11 Z9 11 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2006 VL 34 IS 5 BP 1866 EP 1872 DI 10.1109/TPS.2006.883347 PN 1 PG 7 WC Physics, Fluids & Plasmas SC Physics GA 097ID UT WOS:000241439700037 ER PT J AU Ghogho, M Swami, A AF Ghogho, Mounir Swami, Ananthram TI Training design for multipath channel and frequency-offset estimation in MIMO systems SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE communication channels; frequency estimation; identification; synchronization; training ID SELECTIVE FADING CHANNELS; OFDM SYSTEMS; TRANSMISSIONS; PLACEMENT AB This paper addresses the problem of training design for frequency-selective channel and carrier frequency-offset (CFO) estimation in single- and multiple-antenna systems under different energy-distribution constraints. The performance metric used here is the Cramer-Rao bound (CRB). The paper first addresses the CFO-free case and then generalizes the results to include CFO-corrupted scenarios. Training sequences are designed that render the CRB for the CFO independent of the channel zeros. The proposed training designs also facilitate simple implementation of the maximum-likelihood CFO and channel estimators. Simulation results illustrate the merits of the proposed training designs. C1 Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. Army Res Lab, Adelphi, MD 20783 USA. RP Ghogho, M (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. EM m.ghogho@ieee.org; a.swami@ieee.org NR 25 TC 40 Z9 42 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD OCT PY 2006 VL 54 IS 10 BP 3957 EP 3965 DI 10.1109/TSP.2006.879318 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 087XK UT WOS:000240775900026 ER PT J AU Misra, S Swami, A Tong, L AF Misra, Saswat Swami, Ananthram Tong, Lang TI Cutoff rate optimal binary inputs with imperfect CSI SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article; Proceedings Paper CT IEEE International Symposium on Information Theory CY JUN 27-JUL 02, 2004 CL Chicago, IL SP IEEE, IEEE Informat Theory Soc, Motorola Labs, Qualcomm, Broadcom, IBM Res, Texas Instruments, Microsoft, DARPA, NSF, ONR, Dept Navy Sci & Technol, Flarion, Lee Ctr Adv Network Caltech DE adaptive modulation; cutoff rate; correlated fading; Doppler; imperfect CSI ID RAYLEIGH-FADING CHANNELS; SYMBOL ASSISTED MODULATION; CAPACITY; COMMUNICATION; TRANSMISSIONS; OFDM AB We use the cutoff rate to study the optimal binary input distributions for the Rayleigh flat-fading channel with imperfect receiver channel state information (CSI). First, we evaluate the cutoff rate and analyze the optimal binary input as a function of the CSI quality and receiver SNR. Next, we study the limiting distributions - BPSK and On-Off Keying (OOK) and derive an analytic design rule that allows adaptive switching between these two as the receiver CSI changes. We establish the virtues of a modulation scheme that employs only these limiting distributions, rather than the full spectrum of binary inputs. Finally, we use our results to design an adaptive modulation scheme for Pilot Symbol Assisted Modulation systems. We show that switching between just BPSK and equiprobable-OOK is nearly optimal for moderate to large SNR, and that switching between BPSK and generalized-OOK is nearly optimal for all SNR. C1 Army Res Lab, Adelphi, MD 20783 USA. Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14850 USA. RP Misra, S (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM smisra@arl.army.mil; aswami@arl.army.mil; ltong@ece.cornell.edu NR 34 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD OCT PY 2006 VL 5 IS 10 BP 2903 EP 2913 DI 10.1109/TWC.2006.04665 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 097VW UT WOS:000241478400034 ER PT J AU Ockenhouse, CF Hu, WC Kester, KE Cummings, JF Stewart, A Heppner, DG Jedlicka, AE Scott, AL Wolfe, ND Vahey, M Burke, DS AF Ockenhouse, Christian F. Hu, Wan-chung Kester, Kent E. Cummings, James F. Stewart, Ann Heppner, D. Gray Jedlicka, Anne E. Scott, Alan L. Wolfe, Nathan D. Vahey, Maryanne Burke, Donald S. TI Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria SO INFECTION AND IMMUNITY LA English DT Article ID INTERCELLULAR-ADHESION MOLECULE-1; PLASMODIUM-FALCIPARUM MALARIA; VASCULAR ENDOTHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; GLYCOSYLPHOSPHATIDYLINOSITOL TOXIN; PROINFLAMMATORY RESPONSES; INFECTED ERYTHROCYTES; CEREBRAL MALARIA; INNATE IMMUNITY; NADPH-OXIDASE AB Using genome-wide expression profiles from persons either experimentally challenged with malaria-infected mosquitoes or naturally infected with Plasmodium falciparum malaria, we present details of the transcriptional changes that occur with infection and that either are commonly shared between subjects with presymptomatic and clinically apparent malaria or distinguish these two groups. Toll-like receptor signaling through NF-kappa B pathways was significantly upregulated in both groups, as were downstream genes that function in phagocytosis and inflammation, including the cytokines tumor necrosis factor alpha, gamma interferon (IFN-gamma), and interleukin-1 beta (IL-1 beta). The molecular program derived from these signatures illuminates the closely orchestrated interactions that regulate gene expression by transcription factors such as IRF-1 in the IFN-gamma signal transduction pathway. Modulation of transcripts in heat shock and glycolytic enzyme genes paralleled the intensity of infection. Major histocompatibility complex class I molecules and genes involved in class II antigen presentation are significantly induced in 90% of malaria-infected persons regardless of group. Differences between early presymptomatic infection and natural infection involved genes that regulate the induction of apoptosis through mitogen-activated protein (MAP) kinases and signaling pathways through the endogenous pyrogen IL-1 beta, a major inducer of fever. The induction of apoptosis in peripheral blood mononuclear cells from patients with naturally acquired infection impacted the mitochondrial control of apoptosis and the activation of MAP kinase pathways centered around MAPK14 (p38 alpha and p38 beta). Our findings confirm and extend findings regarding aspects of the earliest responses to malaria infection at the molecular level, which may be informative in elucidating how innate and adaptive immune responses may be modulated in different stages of infection. C1 Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD 20910 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Microbiol & Immunol, Baltimore, MD 21205 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. RP Ockenhouse, CF (reprint author), Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. EM chris.ockenhouse@na.amedd.army.mil RI Kester, Kent/A-2114-2011; OI Kester, Kent/0000-0002-5056-0802; /0000-0002-5704-8094 NR 49 TC 69 Z9 70 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2006 VL 74 IS 10 BP 5561 EP 5573 DI 10.1128/IAI.00408-06 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 090RF UT WOS:000240967900015 PM 16988231 ER PT J AU Bhattacharjee, AK Izadjoo, MJ Zollinger, WD Nikolich, MP Hoover, DL AF Bhattacharjee, Apurba K. Izadjoo, Mina J. Zollinger, Wendell D. Nikolich, Mikeljon P. Hoover, David L. TI Comparison of protective efficacy of subcutaneous versus intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine SO INFECTION AND IMMUNITY LA English DT Article ID OUTER-MEMBRANE PROTEIN; NEISSERIA-MENINGITIDIS; O-POLYSACCHARIDE; ESCHERICHIA-COLI; COMPLEX VACCINE; BALB/C MICE; ABORTUS; INFECTION; ANTIGEN; IMMUNOGENICITY AB Groups of mice were immunized either subcutaneously or intranasally with purified Brucella melitensis lipopolysaccharide (LPS) or with LPS as a noncovalent complex with Neisseria meningitidis group B outer membrane protein (LPS-GBOMP). Control mice were inoculated with sterile saline. Two doses of vaccine were given 4 weeks apart. Mice were challenged intranasally with virulent B. melitensis strain 16M 4 weeks after the second dose of vaccine. Sera, spleens, lungs, and livers of mice were harvested 8 weeks after challenge. The bacterial loads in the organs were determined by culture on brucella agar plates. Protective efficacy was determined by comparing the clearance of bacteria from organs of immunized mice with the clearance of bacteria from organs of control mice. At 8 weeks postchallenge there was significant protection from disseminated infection of spleens and livers of mice intranasally immunized with either vaccine compared to infection of control mice (P < 0.01). There was no significant difference in clearance of bacteria from the lungs of immunized mice and control mice. However, mice immunized subcutaneously with either LPS or LPS-GBOMP vaccine showed significant protection against infection of the spleen (P < 0.001), liver (P < 0.001), and lungs (P < 0.05). These results show that intranasal immunization of mice with either vaccine provided significant protection against disseminated infection of the spleen and liver but subcutaneous immunization of mice with the vaccines conferred significant protection against infection of the spleen, liver, and lungs. C1 Walter Reed Army Inst Res, Dept Bacterial Dis, Silver Spring, MD 20910 USA. Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Bacterial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Apurba.Bhattacharjee@us.army.mil RI Zollinger, Wendell/B-2887-2011; Nikolich, Mikeljon/B-2868-2011 NR 35 TC 21 Z9 22 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2006 VL 74 IS 10 BP 5820 EP 5825 DI 10.1128/IAI.00331-06 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 090RF UT WOS:000240967900044 PM 16988260 ER PT J AU Vitale, L Blanset, D Lowy, I O'Neill, T Goldstein, J Little, SF Andrews, GP Dorough, G Taylor, RK Keler, T AF Vitale, Laura Blanset, Diann Lowy, Israel O'Neill, Thomas Goldstein, Joel Little, Stephen F. Andrews, Gerard P. Dorough, Gary Taylor, Ronald K. Keler, Tibor TI Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity SO INFECTION AND IMMUNITY LA English DT Article ID BACILLUS-ANTHRACIS; LETHAL TOXIN; DENDRITIC CELLS; GUINEA-PIGS; RABBITS; CHALLENGE; RECEPTOR; CIPROFLOXACIN; ENDOCYTOSIS; INFECTION AB The neutralizing antibody response to the protective antigen (PA) component of anthrax toxin elicited by approved anthrax vaccines is an accepted correlate for vaccine-mediated protection against anthrax. We reasoned that a human anti-PA monoclonal antibody (MAb) selected on the basis of superior toxin neutralization activity might provide potent protection against anthrax. The fully human MAb (also referred to as MDX-1303 or Valortim) was chosen from a large panel of anti-PA human MAbs generated using transgenic mice immunized with recombinant PA solely on the basis of in vitro anthrax toxin neutralization. This MAb was effective in prophylactic and postsymptomatic treatment of rabbits exposed to aerosolized anthrax spores, and a single intramuscular injection of 1 mg/kg of body weight fully protected cynomolgus monkeys challenged with aerosolized anthrax spores. Importantly, MAb 1303 defines a novel neutralizing epitope that requires Fc receptor engagement for maximal activity. F(ab')2 fragments of MAb 1303, which retain equivalent affinity for PA, are 10- to 100-fold less potent in neutralizing anthrax toxin in vitro. Addition of Fc receptor-blocking antibodies also greatly reduced the activity of MAb 1303. Moreover, we found that the neutralizing activity of mouse, rabbit, and human antisera elicited by PA vaccines was effectively abrogated by blocking Fc receptors. Selection of an anti-PA MAb by using a functional assay that is a surrogate for protection has resulted in the identification of a fully human MAb with potent activity in vivo and uncovered a previously unrecognized mechanism of antibody-mediated toxin neutralization that is important for currently used anthrax vaccines. C1 Medarex Inc, Bloomsbury, NJ 08804 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. PharmAthene Inc, Annapolis, MD 21401 USA. Dartmouth Coll Sch Med, Dept Microbiol & Immunol, Hanover, NH 03755 USA. Dartmouth Coll, Inst Secur Technol Studies, Hanover, NH 03755 USA. RP Keler, T (reprint author), Celldex Therapeut Inc, 222 Cameron Dr, Philipsburg, NJ 08865 USA. EM tkeler@celldextherapeutics.com FU NIAID NIH HHS [5 U01 AI061314-02, U01 AI061314] NR 28 TC 57 Z9 63 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2006 VL 74 IS 10 BP 5840 EP 5847 DI 10.1128/IAI.00712-06 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 090RF UT WOS:000240967900047 PM 16988263 ER PT J AU Jacobson, EJ Baum, SE Hospenthal, DR AF Jacobson, Eric J. Baum, Sue E. Hospenthal, Duane R. TI Serologic diagnosis of the endemic mycoses SO INFECTIONS IN MEDICINE LA English DT Article DE serologic diagnosis; coccidioidomycosis; histoplasmosis; blastomycosis ID BLASTOMYCOSIS; HISTOPLASMOSIS; WISCONSIN C1 William Beaumont Army Med Ctr, Infect Dis Serv, El Paso, TX 79920 USA. Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Jacobson, EJ (reprint author), William Beaumont Army Med Ctr, Infect Dis Serv, El Paso, TX 79920 USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 USA SN 0749-6524 J9 INFECT MED JI Infect. Med. PD OCT PY 2006 VL 23 IS 10 BP 473 EP + PG 5 WC Infectious Diseases SC Infectious Diseases GA 095MZ UT WOS:000241313200007 ER PT J AU Dong, M He, D Banerjee, P Keller, J AF Dong, Ming He, David Banerjee, Prashant Keller, Jonathan TI Equipment health diagnosis and prognosis using hidden semi-Markov models SO INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY LA English DT Article DE hidden semi-Markov model; condition-based maintenance; diagnosis; prognosis ID CONTINUOUS SPEECH RECOGNITION AB In this paper, the development of hidden semi-Markov models (HSMMs) for equipment health diagnosis and prognosis is presented. An HSMM is constructed by adding a temporal component into the well-defined hidden Markov model (HMM) structures. The HSMM methodology offers two significant advantages over the HMM methodology in equipment health diagnosis and prognosis: (1) it overcomes the modeling limitation of HMM due to the Markov property and therefore improves the power in diagnosis, and (2) it can be directly used for prognosis. The application of the HSMMs to equipment health diagnosis and prognosis is demonstrated with the fault classification application of UH-60A Blackhawk main transmission planetary carriers and prognosis of a hydraulic pump health monitoring application. The effectiveness of the HSMMs is compared with that of the HMMs. The results of the application testing have shown that the HSMMs are capable of identifying the faults under both test cell and on-aircraft conditions while the performance of the HMMs is not comparable with that of the HSMMs. Furthermore, the HSMM-based methodology can be used to estimate the remaining useful life of equipment. C1 Shanghai Jiao Tong Univ, Dept Ind Engn & Management, Shanghai 200030, Peoples R China. Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. USA, RDECOM, Aviat Engn Directorate, Redstone Arsenal, AL 35898 USA. RP Dong, M (reprint author), Shanghai Jiao Tong Univ, Dept Ind Engn & Management, 1954 Hua Shan Rd,Xu Hui Dist, Shanghai 200030, Peoples R China. EM mdong@sjtu.edu.cn RI Dong, Ming/C-6260-2008 NR 18 TC 25 Z9 36 U1 3 U2 22 PU SPRINGER LONDON LTD PI GODALMING PA SWEETAPPLE HOUSE CATTESHALL ROAD, GODALMING GU7 3DJ, SURREY, ENGLAND SN 0268-3768 J9 INT J ADV MANUF TECH JI Int. J. Adv. Manuf. Technol. PD OCT PY 2006 VL 30 IS 7-8 BP 738 EP 749 DI 10.1007/s00170-005-0111-0 PG 12 WC Automation & Control Systems; Engineering, Manufacturing SC Automation & Control Systems; Engineering GA 084TB UT WOS:000240556200019 ER PT J AU MacDonald, JA Henry, PP Letowski, TR AF MacDonald, Justin A. Henry, Paula P. Letowski, Tomasz R. TI Spatial audio through a bone conduction interface SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE bone conduction; spatial audio; head-related transfer function ID SPEECH; SOUND; INTELLIGIBILITY; RECOGNITION AB Headphones are the standard presentation device for radio communication in the military. Although bone conduction devices possess several advantages over headphones for some military applications, they are generally considered inappropriate for inclusion in a multi-channel system. The current study tested the feasibility of a multi-channel bone conduction system by measuring the localizability of spatialized auditory stimuli presented through a pair of bone conduction vibrators. Listeners localized a Gaussian noise stimulus spatialized with individualized head-related transfer functions (HRTFs). The sounds were presented from eight virtual locations on the horizontal plane (0, 45, 90, 135, and 180) through either stereo headphones or a stereo bone conduction system. Localization performance was found to be nearly identical for both audio systems, indicating that bone conduction systems can be effectively used for displaying spatial information. C1 USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP MacDonald, JA (reprint author), USA, Res Lab, Human Res & Engn Directorate, AMSRD,ARL,HR,SD, Aberdeen Proving Ground, MD 21005 USA. EM jmacdonald@arl.army.mil NR 22 TC 24 Z9 25 U1 1 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD OCT PY 2006 VL 45 IS 10 BP 595 EP 599 DI 10.1080/14992020600876519 PG 5 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 111NE UT WOS:000242458300005 PM 17062501 ER PT J AU Murri, GB AF Murri, Gretchen B. TI Testing and life prediction for composite rotor hub flexbeams SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article; Proceedings Paper CT 3rd International Conference on Fatigue of Composites (ICFC3) CY SEP 13-15, 2004 CL Kyoto, JAPAN DE flexbeam; rotor hub; delamination; ply-drop; strain energy release rate ID INTERLAMINAR STRESSES; FATIGUE; METHODOLOGY AB A summary of several studies of delamination in tapered composite laminates with internal ply-drops is presented. Initial studies used 2D FE models to calculate interlaminar stresses at the ply-ending locations in linear tapered laminates under tension loading. Strain energy release rates for delamination in these laminates indicated that delamination would likely start at the juncture of the tapered and thin regions and grow unstably in both directions. Tests of glass/epoxy and graphite/epoxy linear tapered laminates under axial tension delaminated as predicted. Nonlinear tapered specimens were cut from a full-size helicopter rotor hub and were tested under combined constant axial tension and cyclic transverse bending loading to simulate the loading experienced by a rotor hub flexbeam in flight. For all the tested specimens, delamination began at the tip of the outermost dropped-ply group and grew first toward the tapered region. A 2D FE model was created that duplicated the test flexbeam layup, geometry, and loading. Surface strains calculated by the model agreed very closely with the measured surface strains in the specimens. The delamination patterns observed in the tests were simulated in the model by releasing pairs of multi-point constraints (MPCs) along those interfaces. Strain energy release rates associated with the delamination growth were calculated for several configurations and using two different FE analysis codes. Calculations from the codes agreed very closely. The strain energy release rate results were used with material characterization data to predict fatigue delamination onset lives for nonlinear tapered flexbeams with two different ply-dropping schemes. The predicted curves agreed well with the test data for each case studied. (c) 2006 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Vehicle Technol Directorate, Hampton, VA USA. RP Murri, GB (reprint author), USA, Res Lab, Vehicle Technol Directorate, Hampton, VA USA. EM Gretchen.B.Murri@nasa.gov NR 26 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD OCT PY 2006 VL 28 IS 10 BP 1124 EP 1135 DI 10.1016/j.ijfatigue.2006.02.029 PG 12 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 079NW UT WOS:000240184700006 ER PT J AU Frew, DJ Forrestal, MJ Cargile, JD AF Frew, DJ Forrestal, MJ Cargile, JD TI The effect of concrete target diameter on projectile deceleration and penetration depth SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE penetration; concrete target diameter; deceleration-time measurements ID OGIVE-NOSE PROJECTILES; LIMESTONE TARGETS; STEEL PROJECTILES; RODS AB We conducted sets of experiments with three diameters of concrete targets that had an average compressive strength of 23 MPa (3.3 ksi) and 76.2-mm-diameter, 3.0 caliber-radius-head, 13-kg projectiles. The three target diameters were D = 1.83, 1.37, and 0.9 1, so the ratios of the target diameters to the projectile diameter were D/d = 24, 18, and 12. The ogive-nose projectiles were machined from 4340 R(c)45 steel and designed to contain a single-channel acceleration data recorder. Thus, we recorded acceleration during launch and deceleration during penetration. An 83-mm-diameter powder gun launched the 13-kg projectiles to striking velocities between 160 and 340m/s. Measured penetration depths and deceleration-time data were analyzed with a previously published model. We measured negligible changes in penetration depth and only small decreases in deceleration magnitude as the targets' diameters were reduced. (c) 2005 Elsevier Ltd. All rights reserved. C1 Sandia Natl Labs, Albuquerque, NM 87185 USA. USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Frew, DJ (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM djfrew@sandia.gov NR 13 TC 48 Z9 71 U1 5 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT PY 2006 VL 32 IS 10 BP 1584 EP 1594 DI 10.1016/j.ijmpeng.2005.01.012 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 032ZC UT WOS:000236814400003 ER PT J AU Ewing, RG Eiceman, GA Harden, CS Stone, JA AF Ewing, R. G. Eiceman, G. A. Harden, C. S. Stone, J. A. TI The kinetics of the decompositions of the proton bound dimers of 1,4-dimethylpyridine and dimethyl methylphosphonate from atmospheric pressure ion mobility spectra SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY LA English DT Article DE proton bound dimers; ion mobility; dissociation kinetics ID GAS-PHASE; HYDROGEN-BOND; EQUILIBRIA; THERMOCHEMISTRY; SPECTROMETRY; SOLVATION; CLUSTERS; AFFINITY; AMINES AB The rate constants for the dissociations, A(2)H(+) --> AH(+) + A, of the symmetrical proton bound dimers of 2,4-dimethylpyridine and dimethyl methylphosphonate have been determined using an ion mobility spectrometer operating with air as drift gas at ambient pressure. Reaction time was varied by varying the drift electric field. The rate constants were derived from the mobility spectra by determining the rate at which ions decomposed in the drift region. Arrhenius plots with a drift gas containing water vapor at 5 ppm(v) gave the following activation energies and pre-exponential factors: 2,4-dimethylpyridine, 94 +/- 2 kJ mol(-1), log A (s(-1)) = 15.9 +/- 0.4; dimethyl methylphosphonate, 127 +/- 3 kJ mol(-1), log A (s(-1)) = 15.6 +/- 0.3. The enthalpy changes for the decompositions calculated from the activation energies are in accord with literature values for symmetrical proton bound dimers of oxygen and nitrogen bases. The results for dimethyl methylphosphonate were obtained over the temperature range 478-497 K and are practically independent of water concentration (5-2000 ppm(v)). The activation energy for 2,4-dimethylpyridine, obtained over the temperature range 340-359 K, decreased to 31 kJ mol(-1) in the presence of 2.0 x 10(3) ppm(v) of water. At the low temperature, a displacement reaction involving water may account for the decrease. The reduced mobilities of the protonated molecules and the proton bound dimers have been determined over a wide temperature range. While the values for the dimers are essentially independent of the water concentration in the drift gas, those of the protonated molecules show a strong dependence. (C) 2006 Elsevier B.V. All rights reserved. C1 New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA. New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada. RP Ewing, RG (reprint author), New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA. EM ewing@nmt.edu NR 22 TC 28 Z9 28 U1 1 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-3806 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. PD OCT 1 PY 2006 VL 255 BP 76 EP 85 DI 10.1016/j.ijms.2006.04.003 PG 10 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA 082IV UT WOS:000240380900011 ER PT J AU Kendall, AP Kautz, MA Russo, MB Killgore, WDS AF Kendall, Athena P. Kautz, Mary A. Russo, Michael B. Killgore, William D. S. TI Effects of sleep deprivation on lateral visual attention SO INTERNATIONAL JOURNAL OF NEUROSCIENCE LA English DT Article DE attention; cognition; laterality; right-hemisphere; sleep deprivation; vigilance; visual field; visual perception ID SPATIAL ATTENTION; HEMISPHERIC-ASYMMETRY; DECISION-MAKING; NEURAL BASIS; NEGLECT; PERFORMANCE; ALERTNESS; DOMINANCE; CAFFEINE; FATIGUE AB Sleep loss temporarily impairs vigilance and sustained attention. Because these cognitive abilities are believed to be mediated predominantly by the right cerebral hemisphere, this article hypothesized that continuous sleep deprivation results in a greater frequency of inattention errors within the left versus right visual fields. Twenty-one participants were assessed several times each day during a 40-h period of sustained wakefulness and following a night of recovery sleep. At each assessment, participants engaged in a continuous serial addition task while simultaneously monitoring a 150 degrees visual field for brief intermittent flashes of light. Overall, omission errors were most common in the leftmost peripheral field for all sessions, and did not show any evidence of a shift in laterality as a function of sleep deprivation. Relative to rested baseline and postrecovery conditions, sleep deprivation resulted in a global increase in omission errors across all visual locations and a general decline in serial addition performance. These findings argue against the hypothesis that sleep deprivation produces lateralized deficits in attention and suggest instead that deficits in visual attention produced by sleep deprivation are global and bilateral in nature. C1 Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM william.killgore@na.amedd.army.mil OI Killgore, William/0000-0002-5328-0208 NR 31 TC 26 Z9 26 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0020-7454 J9 INT J NEUROSCI JI Int. J. Neurosci. PD OCT PY 2006 VL 116 IS 10 BP 1125 EP 1138 DI 10.1080/00207450500513922 PG 14 WC Neurosciences SC Neurosciences & Neurology GA 075YG UT WOS:000239922900001 PM 16923682 ER PT J AU Voice, TC Long, DT Radovanovic, Z Atkins, JL Mcelmurry, SP Niagolova, ND Dimitrov, P Petropoulos, EA Ganev, VS AF Voice, Thomas C. Long, David T. Radovanovic, Zoran Atkins, James L. Mcelmurry, Shawn P. Niagolova, Nedialka D. Dimitrov, Plamen Petropoulos, Evangelos A. Ganev, Varban S. TI Critical evaluation of environmental exposure agents suspected in the etiology of Balkan endemic nephropathy SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH LA English DT Article DE Balkan endemic nephropathy; exposure assessment; nitrate; nitrite; ammonia; Pliocine lignite; polycyclic aromatic hydrocarbons; heavy metals; aristolochic acid; mycotoxins ID OCHRATOXIN-A; PENICILLIUM-AURANTIOGRISEUM; SELENIUM DEFICIENCY; HUMAN BLOOD; WATER; NEPHROTOXICITY; CONTAMINATION; GROUNDWATER; YUGOSLAVIA; TUNISIA AB Balkan endemic nephropathy (BEN), a kidney disease that occurs in rural villages in Bosnia, Bulgaria, Croatia, Romania, and Serbia, is thought to be linked to an environmental toxin. The authors review literature on proposed environmental exposure agents, report the results of field sampling and analysis studies to evaluate potentials for exposure to proposed agents, and propose criteria for future testing. They used these criteria to evaluate the evidence for suggested hypotheses, concluding that several proposed agents can be eliminated or considered unlikely based on apparent inconsistencies between clinical or epidemiologic evidence related to BEN and toxicologic or exposure evidence related to the agents. Mycotoxins and aristolochic acid are the primary targets of current toxicologic investigations, and while the evidence on exposures for both is potentially consistent, it is insufficient. C1 Michigan State Univ, Dept Civil & Environm Engn, E Lansing, MI 48824 USA. Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. Michigan State Univ, Inst Int Hlth, E Lansing, MI 48824 USA. Kuwait Univ, Dept Epidemiol, Kuwait, Kuwait. Walter Reed Army Inst Res, Washington, DC USA. Natl Ctr Radiobiol & Radiat Protect, Sofia, Bulgaria. Ctr Publ Hlth Protect, Sofia, Bulgaria. Med Univ Sofia, Sofia, Bulgaria. RP Voice, TC (reprint author), Michigan State Univ, Dept Civil & Environm Engn, E Lansing, MI 48824 USA. EM voice@msu.edu RI Atkins, James/B-3577-2011 FU FIC NIH HHS [5D43 TW00641] NR 70 TC 29 Z9 29 U1 1 U2 8 PU ABEL PUBLICATION SERVICES PI BURLINGTON PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA SN 1077-3525 J9 INT J OCCUP ENV HEAL JI Int. J. Occup. Environ. Health PD OCT-DEC PY 2006 VL 12 IS 4 BP 369 EP 376 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 113ZD UT WOS:000242635600011 PM 17168225 ER PT J AU Edgerton, CC Oglesby, RJ Bray, D AF Edgerton, Colin C. Oglesby, Robert J. Bray, David TI Rheumatoid neutrophilic dermatitis SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. RP Edgerton, CC (reprint author), Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD OCT PY 2006 VL 12 IS 5 BP 266 EP 267 DI 10.1097/01.rhu.0000240166.24151.99 PG 2 WC Rheumatology SC Rheumatology GA 092KT UT WOS:000241096200015 PM 17023820 ER PT J AU Goff, MJ Suhr, AW Ward, JA Croley, JK O'Hara, MA AF Goff, Mitchell J. Suhr, Abraham W. Ward, John A. Croley, Janis K. O'Hara, Mary A. TI Effect of adult strabismus on ratings of official US Army photographs SO JOURNAL OF AAPOS LA English DT Article ID PSYCHOSOCIAL IMPLICATIONS; SURGERY; IMPACT AB PURPOSE To determine if strabismus affects the ratings of official U.S. Army photographs. METHODS Photographs of seven women and seven men officers (subjects) were digitally altered to give the impression of strabismus. Four photographs of each subject were obtained: two in an orthotropic state; one in a left exotropic state; and one in a left esotropic state. The photographs were presented randomly to a panel of 38 raters. Masked to the study design, the raters rated every photograph on a 1 to 10 Likert scale. The results were grouped according to eye alignment: two orthotropic groups, one exotropic group, and one esotropic group. Comparisons of the mean ratings were made between each eye alignment group and based on the subject's gender. RESULTS The mean rating for each orthotropic group was 5.4 and 5.5 Likert scale units with a SD of 0.8 and 0.9, respectively (group 1 and group 2). The mean rating for the exotropic group was 5.4 Likert scale units with a SD of 0.7. The mean rating for the esotropic group was 5.1 Likert scale units with a SD of 0.8. Significantly lower ratings were obtained for the esotropic group compared with the orthotropic group (p = 0.028). Women received significantly lower ratings regardless of eye alignment (p = 0.044). CONCLUSIONS This study indicates that the presence of esotropia negatively affects the rating of an official U.S. Army photograph; furthermore, female gender negatively affects ratings. C1 Univ Calif Davis, Dept Ophthalmol, Sacramento, CA 95817 USA. Darnall Army Community Hosp, Ft Hood, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. RP O'Hara, MA (reprint author), Univ Calif Davis, Dept Ophthalmol, 4860 Y St,Suite 2400, Sacramento, CA 95817 USA. EM mary.ohara@ucdmc.ucdavis.edu NR 9 TC 23 Z9 25 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 1091-8531 J9 J AAPOS JI J. AAPOS PD OCT PY 2006 VL 10 IS 5 BP 400 EP 403 DI 10.1016/j.jaapos.2006.04.011 PG 4 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA 104ZG UT WOS:000241998500007 PM 17070472 ER PT J AU Urso, M Scrimgeour, AG Chen, YW Thompson, PD Clarkson, PM AF L. Urso, Maria Scrimgeour, Angus G. Chen, Yi-Wen Thompson, Paul D. Clarkson, Priscilla M. TI Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE metallothioneins; ubiquitin-proteasome pathway; immunohistochemistry; Akt ID UBIQUITIN-PROTEASOME PATHWAY; RAT SOLEUS MUSCLE; GENE-EXPRESSION; DISUSE ATROPHY; DENERVATION ATROPHY; ACTIVATION; DEGRADATION; PROTEOLYSIS; PATTERNS; EXERCISE AB We examined the effects of 48 h of knee immobilization on alterations in mRNA and protein in human skeletal muscle. We hypothesized that 48 h of immobilization would increase gene expression and respective protein products for ubiquitin-proteasome pathway (UPP) components. Also, we used microarray analysis to identify novel pathways. Biopsies were taken from the vastus muscle of five men (20.4 +/- 0.5 yr) before and after 48-h immobilization. Global changes in gene expression were analyzed by use of Affymetrix GeneChips. Candidate genes were confirmed via quantitative RT-PCR. Western blotting (WB) was used to quantify protein products of candidate genes and to assess Akt pathway activation. Immunohistochemistry was used to localize proteins found to be altered when assessed via WB. The greatest percentage of genes showing altered expression with the GeneChip included genes involved in the UPP, metallothionein function, and extracellular matrix (ECM) integrity. Quantitative RT-PCR analysis confirmed increases in mRNA for UPP components [ USP-6, small ubiquitin-related modifier (SUMO-1)] and the metallothioneins (MT2A, MT1F, MT1H, MT1X) and decreases in mRNA content for matrix metalloproteinases (MMP-28, TIMP-1) and ECM structural components [ collagen III (COLIII) and IV (COLIV)]. Only phosphorylated Akt (Ser473, Thr308), COLIII and COLIV protein levels were significantly different postimmobilization (25, 10, 88, and 28% decrease, respectively). Immunohistochemistry confirmed WB showing decreased staining for collagens postimmobilization. Our results suggest that 48 h of immobilization increases mRNA content for components of the UPP and metallothionein function while decreasing mRNA and protein for ECM components as well as decreased phosphorylation of Akt. C1 Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA. USA, Inst Environm Med, Res Lab, Mil Nutr Div, Natick, MA 01760 USA. Childrens Natl Med Ctr, Res Ctr Genet Med, Washington, DC 20010 USA. Hartford Hosp, Div Cardiol, Henry Low Heart Ctr, Hartford, CT 06115 USA. RP Urso, M (reprint author), Univ Massachusetts, Dept Exercise Sci, 110 Totman Bldg, Amherst, MA 01003 USA. EM murso@kin.umass.edu NR 54 TC 74 Z9 78 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 2006 VL 101 IS 4 BP 1136 EP 1148 DI 10.1152/japplphysiol.00180.2006 PG 13 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 084CS UT WOS:000240510000020 PM 16763108 ER PT J AU Svoboda, SJ Bice, TG Gooden, HA Brooks, DE Thomas, DB Wenke, JC AF Svoboda, Steven J. Bice, Terry G. Gooden, Heather A. Brooks, Daniel E. Thomas, Darryl B. Wenke, Joseph C. TI Comparison of bulb syringe and pulsed lavage irrigation with use of a bioluminescent musculoskeletal wound model SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PRESSURE PULSATILE LAVAGE; BENZALKONIUM CHLORIDE; ESCHERICHIA-COLI; IN-VITRO; FRACTURES; INFECTION; EFFICACY; STAPHYLOCOCCUS; BACITRACIN; ADHERENCE AB Background: Despite the fact that wound irrigation is a common surgical procedure, there are many variables, including delivery device, irrigant type, and fluid volume, that have yet to be optimized. The purpose of this study was to compare, with use of transgenic bioluminescent bacteria and standard quantitative microbiological methods, the efficacy of pulsed lavage and bulb syringe irrigation in reducing wound bacterial counts. Methods: A caprine model of a complex, contaminated musculoskeletal wound was developed with use of a bioluminescent strain of Pseudomonas aeruginosa that can be quantified. Luminescent activity was recorded as relative luminescent units with use of a photon-counting camera six hours after the wound was created and inoculated. Twelve goats were randomly assigned to either the pulsed lavage group or the bulb syringe irrigation group. Each wound was irrigated with normal saline solution in 3-L increments for a total of 9 L and was imaged after each 3-L increment. In addition, quantitative culture samples were obtained from different tissues within the wound before and after irrigation. Results: Pulsed lavage decreased the amount of relative luminescent units by 52%, 64%, and 70% at 3, 6, and 9 L, respectively. The bulb syringe irrigation reduced the amount of relative luminescent units by 33%, 44%, and 51% at these same time-points. Significant differences in luminescence were noted between the two groups after both 6 and 9 L of irrigation (p <= 0.04). The correlation coefficients between relative luminescent units and quantitative cultures for the condition before irrigation and after irrigation were r = 0.96 and 0.83, respectively. Conclusions: Pulsed lavage was more effective than bulb syringe irrigation in reducing bacterial luminescence after both 6 and 9 L of irrigation. Both device and volume effects can be demonstrated with use of this model. Bioluminescent bacteria provide a method to visualize bacterial distribution and to quantify the bacteria in a wound. Clinical Relevance: Pulsed lavage is a more effective and efficient method of irrigation to remove bacteria in a complex musculoskeletal wound. In the model we used, pulsed lavage irrigation with 3 L of saline solution resulted in a reduction of approximately the same amount of bacteria as did irrigation with 9 L with use of a bulb syringe. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Svoboda, SJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil NR 33 TC 45 Z9 47 U1 1 U2 4 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD OCT PY 2006 VL 88A IS 10 BP 2167 EP 2174 DI 10.2106/JBJS.E.00248 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 096YI UT WOS:000241412400008 PM 17015593 ER PT J AU James, LC AF James, Larry C. TI Clinical Health Psychology Institute: Integrating clinical health psychology into primary care settings SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Editorial Material DE primary care; clinical health psychology AB This special section of the Journal of Clinical Psychology serves as the proceedings for the inaugural Clinical Health Psychology Institute (CHPI). The goal of the CHPI was to provide attendees with a practical, "hands-on" integration of clinical health psychology research and applied services for primary care practice. This primary care special section is a collection of some of the lectures presented during the one day conference. Dr. James' article on integrating clinical psychology into primary care settings serves as a beginner's guide to primary care integration and how and where to start a primary care program. Additionally, Drs. Earles, James, and Folen provide the rationale for health psycyhologists prescribing non-psychopharmacological agents, as well as an overview of the clinical pathway model for psychologists to prescribe non-psychopharmacological agents for the treatment of obesity. Lastly, Dr. Robin Miyamoto provided an article to serve as a guide for utilization of the codes to enhance reimbursement and assist psychologists in developing sustainable behavioral medicine practices. (c) 2006 Wiley Periodicals, Inc. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP James, LC (reprint author), 95-1056 Mahelu St, Mililani, HI 96789 USA. EM JamesBdaddy@AOL.com NR 0 TC 0 Z9 0 U1 1 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD OCT PY 2006 VL 62 IS 10 BP 1205 EP 1206 DI 10.1002/jclp.20309 PG 2 WC Psychology, Clinical SC Psychology GA 087PE UT WOS:000240753500001 ER PT J AU James, LC AF James, Larry C. TI Integrating clinical psychology into primary care settings SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article; Proceedings Paper CT Conference of the Clinical-Health-Psychology-Institute CY AUG, 2004 CL Honolulu, HI SP Clin Hlth Psychol Inst, Div 38 Hlth Psychol, Amer Pschol Assoc Educ Directorate, Tripler Army Med Ctr DE primary care; health psychology ID DEPRESSION; MANAGEMENT; SERVICES; PROGRAM AB The primary care setting offers a mostly new and exciting opportunity for clinical psychology. Historically, psychology has been relegated to the "back forty," distant and far removed from mainstream medicine in most major hospitals. The primary care integration possibilities for clinical psychology are many. The present article will highlight these opportunities as well as provide the reader with an understanding as to why this conceptual paradigm and practical shift is needed as well as how to integrate clinical psychology services into the primary care setting. (c) 2006 Wiley Periodicals, Inc. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP James, LC (reprint author), 95-1056 Mahelu St, Mililani, HI 96789 USA. EM JamesBdaddy@AOL.com NR 18 TC 3 Z9 3 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD OCT PY 2006 VL 62 IS 10 BP 1207 EP 1212 DI 10.1002/jclp.20306 PG 6 WC Psychology, Clinical SC Psychology GA 087PE UT WOS:000240753500002 PM 16897698 ER PT J AU Earles, JE James, LC Folen, RA AF Earles, Jay E. James, Larry C. Folen, Raymond A. TI Prescribing non-psychopharmacological agents: A new potential role for psychologists in primary care settings and speciality clinics SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article; Proceedings Paper CT Conference of the Clinical-Health-Psychology-Institute CY AUG, 2004 CL Honolulu, HI SP Clin Hlth Psychol Inst, Div 38 Hlth Psychol, Amer Pschol Assoc Educ Directorate, Tripler Army Med Ctr DE primary cared; prescribing ID WEIGHT-LOSS; OBESITY; ORLISTAT; PROGRAM; SCOPE AB At least 10 years have passed since the Department of Defense Psychopharmacology Demonstration Project graduated its first class of psychologists. All graduates of that program were credentialed to prescribe and the program received promising external reviews and audits. The profession has since moved well beyond the initial question, "Can and should psychologists prescribe?" posed over two decades ago. A number of professional schools and training institutions have implemented postdoctoral psychopharmacology training programs and over 20 states are actively pursuing legislative agendas. Given recent initiatives to provide health psychology services within the primary care arena, the authors introduce a new role in the scope of psychology's prescribing activities. They propose that psychopharmacological agents are not the only medications psychologists should be trained to prescribe and psychopharmacology training should include course work and supervision related to treatment within a primary care patient setting in addition to a traditional psychiatric one. The authors provide the rationale for primary care clinical health psychology training as the appropriate mechanism for psychopharmacology education and practice. Public health needs and epidemiological data provide the rationale for health psychologists additionally prescribing non-psychopharmacological agents. (c) 2006 Wiley Periodicals, Inc. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP James, LC (reprint author), 95-1056 Mahelu St, Mililani, HI 96789 USA. EM JamesBdaddy@AOL.com NR 22 TC 1 Z9 1 U1 1 U2 3 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD OCT PY 2006 VL 62 IS 10 BP 1213 EP 1220 DI 10.1002/jclp.20304 PG 8 WC Psychology, Clinical SC Psychology GA 087PE UT WOS:000240753500003 PM 16897696 ER PT J AU Miyamoto, RES AF Miyamoto, Robin E. S. TI Billing effectively with the new health and behavior current procedural terminology codes in primary care and specialty clinics SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article; Proceedings Paper CT Conference of the Clinical-Health-Psychology-Institute CY AUG, 2004 CL Honolulu, HI SP Clin Hlth Psychol Inst, Div 38 Hlth Psychol, Amer Pschol Assoc Educ Directorate, Tripler Army Med Ctr DE CPT codes; health psychology; primary care psychology; billing AB The health and behavior current procedural terminology (CPT) codes introduced in 2003 have gained nationwide acceptance through Medicare and limited acceptance through third party payers. The codes facilitate accurate description and quantification of behavioral medicine services within a primary care or specialty clinic setting. The author reviews their appropriate utilization to enhance reimbursement and facilitate development of self-sustaining behavioral medicine programs. Information is provided on increased use and reimbursement of codes within psychology. Future directions for continued advocacy, increased acceptance, training, and research are discussed. (c) 2006 Wiley Periodicals, Inc. C1 Tripler Army Med Ctr, St Francis Med Ctr, Honolulu, HI 96859 USA. RP Miyamoto, RES (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM robinmiyamoto@hotmail.com NR 18 TC 6 Z9 6 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD OCT PY 2006 VL 62 IS 10 BP 1221 EP 1229 DI 10.1002/jclp.20299 PG 9 WC Psychology, Clinical SC Psychology GA 087PE UT WOS:000240753500004 PM 16897690 ER PT J AU Mallik, A Taylor, DE Runge, K Dufty, JW Cheng, HP AF Mallik, Aditi Taylor, DeCarlos E. Runge, Keith Dufty, James W. Cheng, H. -P. TI Procedure for building a consistent embedding at the QM-CM interface SO JOURNAL OF COMPUTER-AIDED MATERIALS DESIGN LA English DT Article DE classical pair-potentials; embedding; multi-scale; QM/CM; silica ID MOLECULAR MECHANICAL METHODS; AB-INITIO; GEOMETRY OPTIMIZATION; COMPLEX; QM/MM; APPROXIMATIONS; POTENTIALS; TRANSITION; SYSTEMS; STATES AB We propose and test a method for a consistent embedding of a domain treated with detailed quantum mechanical methods (QM) inside a domain treated using classical mechanical (CM) potentials. The physical context of this embedding is the response of a system to mechanical strain which leads to fracture. To provide a quantitative test of qualitative ideas, a model system capable of being treated by QM in its entirety is chosen: a silica nano-rod, comprised of 108 atoms. The embedding is constructed so that the CM description yields the same linear response to mechanical strain as the QM description to within a few percent. An acceptable composite representation of the full system requires (1) a CM potential for the classical domain with appropriate linear mechanical response, (2) pseudo-atoms for the termination of dangling bonds at the QM/CM interface, and (3) a dipole description for the polarization of the remainder of the CM region. A key test for the fidelity of the modeled QM domain is accurate forces and electronic charge densities. We show that the composite has the small strain behavior of the full QM treatment of the nano-rod. We find similar success in the application of this method to two other silica model systems: the notched rod, and a nano-ring. Both transfer Hamiltonian (TH) and density functional theory (DFT) are used for the underlying QM. C1 Intel Corp, Proc Technol Modeling, Hillsboro, OR 97124 USA. USA, Res Lab, Waep & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. Univ Florida, Dept Chem, Quantum Theory Project, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Quantum Theory Project, Gainesville, FL 32611 USA. RP Mallik, A (reprint author), Intel Corp, Proc Technol Modeling, Ronler Acres 3,2501 NW 229 Ave, Hillsboro, OR 97124 USA. EM iamaditi@yahoo.com NR 25 TC 4 Z9 4 U1 1 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0928-1045 J9 J COMPUT-AIDED MATER JI J. Comput-Aided Mater. Des. PD OCT PY 2006 VL 13 IS 1-3 BP 45 EP 60 DI 10.1007/s10820-006-9014-0 PG 16 WC Computer Science, Interdisciplinary Applications; Materials Science, Multidisciplinary SC Computer Science; Materials Science GA 088FV UT WOS:000240798400004 ER PT J AU Mehendale, B Shende, R Subramanian, S Gangopadhyay, S Redner, P Kapoor, D Nicolich, S AF Mehendale, Bhushan Shende, Rajesh Subramanian, Senthil Gangopadhyay, Shubhra Redner, Paul Kapoor, Deepak Nicolich, Steven TI Nanoenergetic composite of mesoporous iron oxide and aluminum nanoparticles SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE al-nanoparticles; burn rate; ordered mesoporous Fe2O3; surfactant templating ID SOL-GEL SYNTHESIS; PRECIPITATION; SURFACTANT; MONOLITHS; EPOXIDES; AEROGELS; SYSTEM; FILMS AB Ordered mesoporous Fe2O3 was synthesized using cetyltrimethylammonium chloride (CTAC) and polyethylene glycol octadecyl ether (Brij 76) surfactant templates. The gel time was monitored as a function of the concentration ratio of precursor to the surfactant. As-prepared FeOOH gels were extracted in ethanol to remove the surfactant and calcined at 200-400 degrees C for 6h so that alpha-Fe2O3 is produced. The FTIR spectra of these gels reveal complete removal of surfactant and water impurities and the presence of Fe-O vibrations. TEM images show ordering of mesopores in the gels prepared using surfactant templating and no ordering of the pores in the gels prepared without surfactant. The gels after calcinations were mixed. C1 Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. USA, ARDEC, Picatinny Arsenal, NJ USA. RP Gangopadhyay, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, 243 EBW,Crossing 6th St & Steward Ave, Columbia, MO 65211 USA. EM gangopadhyays@missouri.edu NR 22 TC 21 Z9 23 U1 0 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0737-0652 J9 J ENERG MATER JI J. Energ. Mater. PD OCT-DEC PY 2006 VL 24 IS 4 BP 341 EP 360 DI 10.1080/07370650600896715 PG 20 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA 097HY UT WOS:000241439200005 ER PT J AU Oh, RC AF Oh, Robert C. TI Can patients with steatohepatitis take statins? - Clinical commentary SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material C1 Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Oh, RC (reprint author), Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU DOWDEN PUBLISHING CORP PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD OCT PY 2006 VL 55 IS 10 BP 905 EP 905 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 098HD UT WOS:000241510700021 ER PT J AU Juliano, P Li, BS Clark, S Mathews, JW Dunne, PC Barbosa-Canovas, GV AF Juliano, Pablo Li, Biansheng Clark, Stephanie Mathews, Jason W. Dunne, Patrick C. Barbosa-Canovas, Gustavo V. TI Descriptive analysis of precooked egg products after high-pressure processing combined with low and high temperatures SO JOURNAL OF FOOD QUALITY LA English DT Article ID HIGH-HYDROSTATIC-PRESSURE; LIQUID WHOLE EGG; CLOSTRIDIUM-BOTULINUM; RHEOLOGICAL CHARACTERISTICS; FOOD PROTEINS; INACTIVATION; GELS; TEXTURE; QUALITY; SPORES AB The quality descriptors of precooked scrambled egg patties were evaluated after high-pressure treatment at low and high temperatures. A commercial egg patty was thermally pressurized at 90C/0.1-675 MPa and 30-90C/675 MPa. A trained descriptive panel evaluated untreated and treated products. Additional tests included texture profile analysis, color, pH and water loss. After treatment at 30C/675 Mpa, the egg patty maintained its sensory profile. Treatments at gelation temperatures >= 70C and 675 MPa increased firmness and density scores, and water loss, compared to lower temperatures. Formulation modification with xanthan gum, ethylenediaminetetraacetic acid (EDTA) and flavors reduced the instrumental hardness by 25-41%, while syneresis decreased 50-55%, in agreement with findings of smaller particle size, smoother mouthfeel and lower dryness scores. The flavor profile of modified formulation after 70C/675 MPa or 90C/675 MPa treatments was similar to controls. Reformulation with xanthan gum, EDTA and flavors allowed maintenance of initial characteristics after thermal pressurization. High-pressure processing at low temperatures is promising for preserving precooked scrambled egg patties while retaining sensory profile at selected conditions. C1 Washington State Univ, Dept Biol Syst Engn, Ctr Nonthermal Proc Food, Pullman, WA 99164 USA. Washington State Univ, Dept Food Sci & Human Nutr, Pullman, WA 99164 USA. Michael Foods Egg Prod Co, Gaylord, MN 55334 USA. USA, Dev & Engn Command, Natick, MA 01760 USA. RP Barbosa-Canovas, GV (reprint author), Washington State Univ, Dept Biol Syst Engn, Ctr Nonthermal Proc Food, 220 Grimes Way LJ Smith Hall, Pullman, WA 99164 USA. EM barbosa@mail.wsu.edu RI Juliano, Pablo/H-9251-2013 OI Juliano, Pablo/0000-0002-7425-8085 NR 52 TC 11 Z9 11 U1 0 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0146-9428 J9 J FOOD QUALITY JI J. Food Qual. PD OCT PY 2006 VL 29 IS 5 BP 505 EP 530 DI 10.1111/j.1745-4557.2006.00090.x PG 26 WC Food Science & Technology SC Food Science & Technology GA 099VO UT WOS:000241625500007 ER PT J AU Weber, LJ Goodwin, RA Li, S Nestler, JM Anderson, JJ AF Weber, L. J. Goodwin, R. A. Li, S. Nestler, J. M. Anderson, J. J. TI Application of an Eulerian-Lagranglan-Agent method (ELAM) to rank alternative designs of a juvenile fish passage facility SO JOURNAL OF HYDROINFORMATICS LA English DT Article DE computational fluid dynamics; computer-based simulation; ecohydraulics; ecological modeling; environmental hydroinformatics; fish modeling; fish passage; individual-based modeling ID HYDRAULIC FLOW SIMULATION; LATERAL-LINE; BEHAVIOR; WATER; RESPONSES; STIMULI; MODEL AB The Eulerian-Lagrangian-Agent method (ELAM) couples three modelling approaches into a single, integrated simulation environment: (i) Eulerian descriptions, (ii) Lagrangian formulations, and (iii) agent reference frameworks. ELAMS are particularly effective at decoding and simulating the motion dynamics of individual aquatic organisms, using the output of high fidelity computational fluid dynamics (CFD) models to represent complex flow fields. Here we describe the application of an ELAM to design a juvenile fish passage facility at Wanapum Dam on the Columbia River in the United States. This application is composed of three parts: (1) an agent-based model, that simulates the movement decisions made by individual fish, (2) an Eulerian CFD model that solves the 3D Reynolds-averaged Navier-Stokes (RANS) equations with a standard k-epsilon turbulence model with wall functions using a multi-block structured mesh, and (3) a Lagrangian particle-tracker used to interpolate information from the Eulerian mesh to point locations needed by the agent model and to track the trajectory of each virtual fish in three dimensions. We discuss aspects of the computational mesh topology and other CFD modeling topics important to this and future applications of the ELAM model for juvenille salmon, the Numerical Fish Surrogate. The good match between forecasted (virtual) and measured (observed) fish passage proportions demonstrates the value-added benefit of using agent-based models (i.e. the Numerical Fish Surrogate model) as part of common engineering practice for fish passage design and, more fundamentally, to simulate complex ecological processes. C1 Univ Iowa, Coll Engn, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA. USA Engineer Res & Dev Ctr, Environm Lab, Portland, OR 97208 USA. USA Engineer Res & Dev Ctr, Environm Modeling & Syst Wide Assessment Ctr CEER, Portland, OR 97208 USA. Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA. RP Weber, LJ (reprint author), Univ Iowa, Coll Engn, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA. EM larry-weber@uiowa.edu; rag12@cornell.edu; songheng-li@uiowa.edu; john.m.nestler@erdc.usace.army.mit; jim@cbr.washington.edu NR 45 TC 11 Z9 13 U1 3 U2 11 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1464-7141 J9 J HYDROINFORM JI J. Hydroinform. PD OCT PY 2006 VL 8 IS 4 BP 271 EP 295 DI 10.2166/hydro.2006.006 PG 25 WC Computer Science, Interdisciplinary Applications; Engineering, Civil; Environmental Sciences; Water Resources SC Computer Science; Engineering; Environmental Sciences & Ecology; Water Resources GA 082CY UT WOS:000240365500004 ER PT J AU Wallace, R Pathak, K Fife, M Jones, NL Holland, JP Stuart, D Harris, J Butler, C Richards, DR AF Wallace, R. Pathak, K. Fife, M. Jones, N. L. Holland, J. P. Stuart, D. Harris, J. Butler, C. Richards, D. R. TI Information infrastructure for integrated ecohydraulic and water resources modeling and assessment SO JOURNAL OF HYDROINFORMATICS LA English DT Article DE computational infrastructure; computer-based modeling and assessment tools; cyberinfrastructure; ecohydraulics; environmental hydroinformatics AB Watershed management increasingly requires ecohydraulic modeling and assessment within a regional context, rather than on a project-by-project basis. Such holistic modeling and assessment require evaluation capabilities across multiple temporal and spatial scales. Thus, modeling and assessment tools must be integrated in a scientifically and computationally effective infrastructure. The US Army Engineer Research and Development Center, in concert with the Hydrologic Engineering Center and its academic partners, including Brigham Young University, is establishing a comprehensive set of hydroinformatics modeling and assessment tools for ecohydraulic and water resources management applications, all linked based on a common data and information infrastructure. This paper presents the attributes of this information infrastructure and compares it with the analogous integration initiatives elsewhere. C1 USA Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. USA Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. Brigham Young Univ, Environm Modeling Res Lab, Provo, UT 84602 USA. USA Engineer Inst Water Resources, Hydrol Engn Ctr, Davis, CA 95616 USA. RP Holland, JP (reprint author), USA Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeffery.holland@us.army.mil NR 22 TC 3 Z9 3 U1 0 U2 3 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1464-7141 J9 J HYDROINFORM JI J. Hydroinform. PD OCT PY 2006 VL 8 IS 4 BP 317 EP 333 DI 10.2166/hydro.2006.007 PG 17 WC Computer Science, Interdisciplinary Applications; Engineering, Civil; Environmental Sciences; Water Resources SC Computer Science; Engineering; Environmental Sciences & Ecology; Water Resources GA 082CY UT WOS:000240365500006 ER PT J AU Fowler, EV Chavchich, M Chen, NH Peters, JM Kyle, DE Gatton, ML Cheng, Q AF Fowler, Elizabeth V. Chavchich, Marina Chen, Nanhua Peters, Jennifer M. Kyle, Dennis E. Gatton, Michelle L. Cheng, Qin TI Physical linkage to drug resistance genes results in conservation of var genes among west pacific Plasmodium falciparum isolates SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 53rd Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 07-11, 2004 CL Miami Beach, FL SP Amer Soc Trop Med & Hyg ID CHLOROQUINE RESISTANCE; MALARIA PARASITES; INFECTED ERYTHROCYTES; CHONDROITIN SULFATE; ADHESIVE DOMAINS; BINDING DOMAIN; EAST-TIMOR; IDENTIFICATION; PFCRT; DIVERSITY AB The multicopy var gene family encoding the variant surface antigen Plasmodium falciparum erythrocyte membrane protein 1 is highly diverse, with little overlap between different P. falciparum isolates. We report 5 var genes (varS1-varS5) that are shared at relatively high frequency among 63 genetically diverse P. falciparum isolates collected from 5 islands in the West Pacific region. The varS1, varS2, and varS3 genes were localized to the internal region on chromosome 4, similar to 200 kb from pfdhfr-ts, whereas varS4 and varS5 were mapped to an internal region of chromosome 7, within 100 kb of pfcrt. The presence of varS2 and varS3 were significantly correlated with the pyrimethamine-resistant pfdhfr genotype, whereas varS4 was strongly correlated with the chloroquine-resistant pfcrt genotype. Thus, the conservation of these var genes is the result of their physical linkage with drug-resistant genes in combination with the antimalarial drug pressure in the region. C1 Univ Queensland, Dept Drug Resistance & Diagnost, Australian Army Malaria Inst, Brisbane, Qld, Australia. Univ Queensland, Queensland Inst Med Res, Brisbane, Qld, Australia. Univ Queensland, Australian Ctr Int Trop Hlth & Nutr, Brisbane, Qld, Australia. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Cheng, Q (reprint author), Univ Queensland, Dept Drug Resistance & Diagnost, Australian Army Malaria Inst, Brisbane, Qld, Australia. EM qin.cheng@defence.gov.au FU NIAID NIH HHS [5R01AI047500-04/05, R01 AI047500, R01 AI047500-04A2, R01 AI047500-05] NR 48 TC 10 Z9 10 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2006 VL 194 IS 7 BP 939 EP 948 DI 10.1086/506619 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 081LE UT WOS:000240318300011 PM 16960782 ER PT J AU Dye, HA AF Dye, H. A. TI Non-trivial realizations of virtual link diagrams SO JOURNAL OF KNOT THEORY AND ITS RAMIFICATIONS LA English DT Article; Proceedings Paper CT Conference on Knots in Washington XX CY FEB 11-13, 2005 CL George Washington Univ, Washington, DC HO George Washington Univ ID KNOT-THEORY AB A realization of a virtual link diagram is obtained by choosing over/under markings for each virtual crossing. Any realization can also be obtained from some representation of the virtual link. (A representation of a virtual link is a link diagram on an oriented 2-dimensional surface.) We prove that if a minimal genus representation meets certain criteria then there is a minimal genus representation resulting in a knotted realization. C1 US Mil Acad, MADN MATH, West Point, NY 10996 USA. RP Dye, HA (reprint author), US Mil Acad, MADN MATH, 646 Swift Rd, West Point, NY 10996 USA. EM hdye@ttocs.org NR 16 TC 1 Z9 1 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-2165 J9 J KNOT THEOR RAMIF JI J. Knot Theory Ramifications PD OCT PY 2006 VL 15 IS 8 BP 963 EP 981 DI 10.1142/S0218216506004890 PG 19 WC Mathematics SC Mathematics GA 114PH UT WOS:000242677600004 ER PT J AU Hanly, EJ Miller, BE Kumar, R Hasser, CJ Coste-Maniere, E Talamini, MA Aurora, AA Schenkman, NS Marohn, MR AF Hanly, Eric J. Miller, Brian E. Kumar, Rajesh Hasser, Christopher J. Coste-Maniere, Eve Talamini, Mark A. Aurora, Alexander A. Schenkman, Noah S. Marohn, Michael R. TI Mentoring console improves collaboration and teaching in surgical robotics SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES LA English DT Article; Proceedings Paper CT 67th Annual Meeting of the Society-of-University-Surgeons/1st Annual Academic Surgical Congress CY FEB 07-11, 2006 CL San Diego, CA SP Assoc Acad Surg, Soc Univ Surg ID PROSTATECTOMY; TECHNOLOGY; EXPERIENCE AB Background: One of the most significant limitations of surgical robots has been their inability to allow multiple surgeons and surgeons-in-training to engage in collaborative control of robotic surgical instruments. We report the initial experience with a novel two-headed da Vinci surgical robot that has two collaborative modes: the "swap" mode allows two surgeons to simultaneously operate and actively swap control of the robot's four arms, and the "nudge" mode allows them to share control of two of the robot's arms. Materials and Methods: The utility of the mentoring console operating in its two collaborative modes was evaluated through a combination of dry laboratory exercises and animal laboratory surgery. The results from surgeon-resident collaborative performance of complex three-handed surgical tasks were compared to results from single-surgeon and single-resident performance. Statistical significance was determined using Student's t-test. Results: Collaborative surgeon-resident swap control reduced the time to completion of complex three-handed surgical tasks by 25% compared to single-surgeon operation of a four-armed da Vinci (P < 0.01) and by 34% compared to single-resident operation (P < 0.001). While swap mode was found to be most helpful during parts of surgical procedures that require multiple hands (such as isolation and division of vessels), nudge mode was particularly useful for guiding a resident's hands during crucially precise steps of an operation (such as proper placement of stitches). Conclusion: The da Vinci mentoring console greatly facilitates surgeon collaboration during robotic surgery and improves the performance of complex surgical tasks. The mentoring console has the potential to improve resident participation in surgical robotics cases, enhance resident education in surgical training programs engaged in surgical robotics, and improve patient safety during robotic surgery. C1 Johns Hopkins Univ, Sch Med, Baltimore, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Intuit Surg Incorporated, Sunnyvale, CA USA. RP Marohn, MR (reprint author), Johns Hopkins Univ Hosp, 600 N Wolfe St,Halsted 608, Baltimore, MD 21287 USA. EM mmarohn1@jhmi.edu NR 14 TC 28 Z9 29 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1092-6429 J9 J LAPAROENDOSC ADV S JI J. Laparoendosc. Adv. Surg. Tech. PD OCT PY 2006 VL 16 IS 5 BP 445 EP 451 DI 10.1089/lap.2006.16.445 PG 7 WC Surgery SC Surgery GA 091ZH UT WOS:000241066300003 PM 17004866 ER PT J AU Sanghadasa, M Ashley, PR Webster, EL Cocke, C Lindsay, GA Guenthner, AJ AF Sanghadasa, Mohan Ashley, Paul R. Webster, Eric L. Cocke, Carys Lindsay, Geoffrey A. Guenthner, Andrew J. TI Simplified technique for efficient fiber-polymer-waveguide power coupling using a customized cladding with tunable index of refraction SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article DE integrated optics; optical fibers; optical waveguides; polymer. ID DIFFUSED LINBO3 WAVEGUIDES; MODE SIZE TRANSFORMER; CHANNEL WAVEGUIDES; MULTIMODE; CHIP AB A novel technique to minimize the mode mismatch between the fiber and waveguide modes in integrating optical fiber to polymer waveguides is presented. The mode fields at the facets of the waveguides were tailored, optimizing the waveguide geometry as well as tuning the index of refraction of the lower cladding near the facets, by chemical composition. No additional processes were required after the core was deposited. The modified lower cladding can be integrated efficiently with any other lower-cladding material used in the remaining portion of the waveguide, resulting in hybrid waveguides. A power-coupling loss as low as 0.46 dB at the fiber-waveguide interfaces was demonstrated with the available fiber. C1 AEgis Technol Grp Inc, Huntsville, AL 35806 USA. USA, Res Dev & Engn Command, Weapons Sci Directorate, Redstone Arsenal, AL 35898 USA. NAVAIR, Dept Res, China Lake, CA 93555 USA. RP Webster, EL (reprint author), AEgis Technol Grp Inc, Huntsville, AL 35806 USA. EM Mohan.Sanghadasa@us.army.mil; Paul.Ashley@us.army.mil; Eric.L.Webster@us.anny.mil; Carys.Cocke@us.ar-my.mil; Lindsay@navy.mil; Andrew.Guenthner@navy.mil NR 24 TC 6 Z9 6 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD OCT PY 2006 VL 24 IS 10 BP 3816 EP 3823 DI 10.1109/JLT.2006.881837 PG 8 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 098SI UT WOS:000241542700031 ER PT J AU Bauer, TN Truxillo, DM Tucker, JS Weathers, V Bertolino, M Erdogan, B Campion, MA AF Bauer, Talya N. Truxillo, Donald M. Tucker, Jennifer S. Weathers, Vaunne Bertolino, Marilena Erdogan, Beffin Campion, Michael A. TI Selection in the information age: The impact of privacy concerns and computer experience on applicant reactions SO JOURNAL OF MANAGEMENT LA English DT Article DE online selection; personal information privacy; applicant reactions; familiarity with computers; organizational justice ID COGNITIVE-ABILITY TESTS; TEST-TAKING MOTIVATION; FACE-TO-FACE; ORGANIZATIONAL JUSTICE; PERSONNEL-SELECTION; PERCEPTIONS; TECHNOLOGY; FAIRNESS; MANAGEMENT; INTERNET AB The authors examined the influence of personal information privacy concerns and computer experience on applicants' reactions to online screening procedures. Study I used a student sample simulating application for a fictitious management intern job with a state personnel agency (N = 117) and employed a longitudinal, laboratory-based design. Study 2 employed afield sample of actual applicants (N = 396) applying for jobs online. As predicted, procedural justice mediated the relationship between personal information privacy concerns and test-taking motivation, organizational attraction, and organizational intentions in the laboratory and field. Experience with computers moderated the relationship between procedural justice with test-taking motivation and organizational intentions in the field but not in the laboratory sample. Implications are discussed in terms of the importance of considering applicants'personal information privacy concerns and testing experience when designing online recruitment and selection systems. C1 Portland State Univ, Sch Business, Portland, OR 97207 USA. Portland State Univ, Dept Psychol, Portland, OR 97207 USA. US Army Res Inst, Ft Benning, GA 31995 USA. Univ Trent, Dipartimento Sci Cogniz Formaz, I-38068 Rovereto, Italy. Purdue Univ, Krannert Sch Management, W Lafayette, IN 47907 USA. RP Bauer, TN (reprint author), Portland State Univ, Sch Business, Portland, OR 97207 USA. EM talyaB@sba.pdx.edu NR 55 TC 27 Z9 29 U1 9 U2 45 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0149-2063 EI 1557-1211 J9 J MANAGE JI J. Manag. PD OCT PY 2006 VL 32 IS 5 BP 601 EP 621 DI 10.1177/0149206306289829 PG 21 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 087VP UT WOS:000240771200001 ER PT J AU Matthews, B Sylvie, JR Lee, SH Thomas, SR Chapman, RE Gibson, GE AF Matthews, Benjamin Sylvie, Jonathan R. Lee, Sang-Hoon Thomas, Stephen R. Chapman, Robert E. Gibson, G. Edward, Jr. TI Addressing security in early stages of project life cycle SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article AB This article summarizes the first phase of a three-phase research effort to develop and deploy best practices for project security on industrial projects. It shows how to address security early in the project life cycle and its impacts on the capital facility delivery process. Three dimensions of security for capital projects are examined-physical, personnel, and information-and linked to the key concepts of threats, consequences, and vulnerability assessment. A select set of industry best practices provides the basis for integrating security into the project delivery process. This selection includes six best practices: (1) preproject planning; (2) alignment; (3) design effectiveness; (4) constructability; (5) materials management; and (6) planning for start-up. The article outlines the methodology for updating best practices to include security. It includes a brief description of each practice and documents the key updates for incorporating security-related considerations into the practice. Security implications for the project delivery process are provided as well as recommendations to industry. C1 USAF, Haslett, MI 48840 USA. USA, Austin, TX 78739 USA. Univ Houston, Dept Engn Technol, Houston, TX 77204 USA. Univ Texas, Austin, TX 78759 USA. Natl Inst Stand & Technol, Off Appl Econ, Gaithersburg, MD 20899 USA. Univ Alabama, Dept Civil Construct & Environm Engn, Tuscaloosa, AL 35487 USA. RP Matthews, B (reprint author), USAF, 5793 Bayonne Ave, Haslett, MI 48840 USA. NR 16 TC 4 Z9 4 U1 2 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0742-597X J9 J MANAGE ENG JI J. Manage. Eng. PD OCT PY 2006 VL 22 IS 4 BP 196 EP 202 DI 10.1061/(ASCE)0742-597X(2006)22:4(196) PG 7 WC Engineering, Industrial; Engineering, Civil SC Engineering GA 088CT UT WOS:000240789800005 ER PT J AU Rice, BM Byrd, EFC AF Rice, Betsy M. Byrd, Edward F. C. TI Theoretical chemical characterization of energetic materials SO JOURNAL OF MATERIALS RESEARCH LA English DT Review ID MOLECULAR-DYNAMICS SIMULATIONS; QUANTUM-MECHANICAL CALCULATIONS; NITRAMINE CRYSTALS; SOLID NITROMETHANE; MGSIO3 PEROVSKITE; AB-INITIO; RDX; PACKING; HMX; TRANSFERABILITY AB Our research is focused on developing computational capabilities for the prediction of properties of energetic materials associated with performance and sensitivity. Additionally, we want to identify and characterize the dynamic processes that influence conversion of an energetic material to products upon initiation. We are attempting to achieve these goals through the use of standard atomistic simulation methods. In this paper, various theoretical chemistry methods and applications to energetic materials will be described. Current capabilities in predicting structures, thermodynamic properties, and dynamic behavior of these materials will be demonstrated. These are presented to exemplify how information generated from atomistic simulations can be used in the design, development, and testing of new energetic materials. In addition to illustrating current capabilities, we will discuss limitations of the methodologies and needs for advancing the state of the art in this area. C1 USA, Res Lab, Ballist & Weap Concepts Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Rice, BM (reprint author), USA, Res Lab, Ballist & Weap Concepts Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM betsyr@arl.army.mil NR 40 TC 23 Z9 27 U1 1 U2 22 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD OCT PY 2006 VL 21 IS 10 BP 2444 EP 2452 DI 10.1557/JMR.2006.0329 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA 091IW UT WOS:000241021600003 ER PT J AU Crane, C AF Crane, Conrad TI Sabres over MiG Alley: The F-86 and the battle for air superiority in Korea. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Mil Hist Inst, Carlisle, PA USA. RP Crane, C (reprint author), USA, Mil Hist Inst, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2006 VL 70 IS 4 BP 1105 EP 1106 DI 10.1353/jmh.2006.0234 PG 2 WC History SC History GA 091GK UT WOS:000241014900011 ER PT J AU Andrade, D AF Andrade, Dale TI ARVN: Life and death in the South Vietnamese army. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Ctr Mil Hist, Washington, DC USA. RP Andrade, D (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2006 VL 70 IS 4 BP 1107 EP 1108 DI 10.1353/jmh.2006.0215 PG 2 WC History SC History GA 091GK UT WOS:000241014900013 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI The Alabama, British neutrality, and the American Civil War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, War Coll, Carlisle, PA USA. RP Weddle, KJ (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2006 VL 70 IS 4 BP 1141 EP 1142 DI 10.1353/jmh.2006.0293 PG 2 WC History SC History GA 091GK UT WOS:000241014900039 ER PT J AU Warden, DL Gordon, B McAllister, TW Silver, JM Barth, JT Bruns, J Drake, A Gentry, T Jagoda, A Katz, DI Kraus, J Labbate, LA Ryan, LM Sparling, MB Walters, B Whyte, J Zapata, A Zitnay, G AF Warden, Deborah L. Gordon, Barry McAllister, Thomas W. Silver, Jonathan M. Barth, Jeffery T. Bruns, John Drake, Angela Gentry, Tony Jagoda, Andy Katz, Douglas I. Kraus, Jess Labbate, Lawrence A. Ryan, Laurie M. Sparling, Molly B. Walters, Beverly Whyte, John Zapata, Ashley Zitnay, George CA Neurobehavioral Guidelines Workin TI Neurobehavioral guidelines working group members SO JOURNAL OF NEUROTRAUMA LA English DT Review DE aggression; brain injury; cognition; evidence based reviews; neurobehavior; pharmacology; psychiatric disorders ID TRAUMATIC BRAIN-INJURY; CLOSED-HEAD-INJURY; DOUBLE-BLIND; AGGRESSIVE-BEHAVIOR; TRICYCLIC ANTIDEPRESSANT; PSYCHIATRIC-DISORDERS; FOLLOW-UP; NEUROPSYCHIATRIC SEQUELAE; METHYLPHENIDATE TREATMENT; LITHIUM-CARBONATE AB There is currently a lack of evidence-based guidelines to guide the pharmacological treatment of neurobehavioral problems that commonly occur after traumatic brain injury (TBI). It was our objective to review the current literature on the pharmacological treatment of neurobehavioral problems after traumatic brain injury in three key areas: aggression, cognitive disorders, and affective disorders/anxiety/psychosis. Three panels of leading researchers in the field of brain injury were formed to review the current literature on pharmacological treatment for TBI sequelae in the topic areas of affective/anxiety/psychotic disorders, cognitive disorders, and aggression. A comprehensive Medline literature search was performed by each group to establish the groups of pertinent articles. Additional articles were obtained from bibliography searches of the primary articles. Group members then independently reviewed the articles and established a consensus rating. Despite reviewing a significant number of studies on drug treatment of neurobehavioral sequelae after TBI, the quality of evidence did not support any treatment standards and few guidelines due to a number of recurrent methodological problems. Guidelines were established for the use of methylphenidate in the treatment of deficits in attention and speed of information processing, as well as for the use of beta-blockers for the treatment of aggression following TBI. Options were recommended in the treatment of depression, bipolar disorder/mania, psychosis, aggression, general cognitive functions, and deficits in attention, speed of processing, and memory after TBI. The evidence-based guidelines and options established by this working group may help to guide the pharmacological treatment of the person experiencing neurobehavioral sequelae following TBI. There is a clear need for well-designed randomized controlled trials in the treatment of these common problems after TBI in order to establish definitive treatment standards for this patient population. C1 Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Dept Neurol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Dept Neurosurg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Washington, DC USA. Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA. Johns Hopkins Univ, Dept Cognit Sci, Baltimore, MD 21218 USA. Dartmouth Coll Sch Med, Dept Psychiat, Lebanon, NH USA. Dartmouth Coll Sch Med, Dept Neuropsychiat, Lebanon, NH USA. NYU, Sch Med, Dept Psychiat, New York, NY USA. Univ Virginia, Sch Med, Dept Psychiat Med, Charlottesville, VA 22908 USA. Univ Virginia, Sch Med, Dept Neurol Surg, Charlottesville, VA 22908 USA. Mt Sinai Sch Med, Dept Emergency Med, New York, NY USA. San Diego Naval Med Ctr, Def & Vet Brain Injury Ctr, San Diego, CA USA. Virginia Commonwealth Univ, Dept Educ, Partnership People Disabil, Richmond, VA USA. Mt Sinai Sch Med, Dept Emergency Med, New York, NY USA. Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. Healthsouth Braintree Rehabil Hosp, Brain Injury Program, Braintree, MA USA. Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. Univ Arkansas Med Sci, Dept Psychiat, Little Rock, AR 72205 USA. VA Med Ctr, Little Rock, AR USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Washington, DC USA. Walter Reed Army Med Ctr, Dept Neurol, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Neurol, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. NYU, Sch Med, Dept Neurosurg, New York, NY USA. Thomas Jefferson Univ, Dept Rehabil Med, Philadelphia, PA 19107 USA. Thomas Jefferson Univ, Albert Einstein Healthcare Network, Moss Rehabil Res Inst, Philadelphia, PA 19107 USA. Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA. Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC USA. Walter Reed Army Med Ctr, Laurel Highlands Neurorehabil, Washington, DC USA. RP Warden, DL (reprint author), NeuroTrauma Fdn, 555 Madison Ave, New York, NY 10022 USA. NR 141 TC 176 Z9 185 U1 3 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT PY 2006 VL 23 IS 10 BP 1468 EP 1501 DI 10.1089/neu.2006.23.1468 PG 34 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 093XL UT WOS:000241203500008 ER PT J AU Dabisch, PA Davis, EA Horsmon, MS Mioduszewski, RJ AF Dabisch, Paul A. Davis, Emily A. Horsmon, Michael S. Mioduszewski, Robert J. TI Development of miotic cross-tolerance between pyridostigmine and sarin vapor SO JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS LA English DT Article ID RECEPTOR; EXPOSURE; PHOSPHORYLATION; DESENSITIZATION; BINDING; CELLS; RATS AB The organophosphorous nerve agent sarin (GB) and the carbarnate pyridostigmine bromide (PB) both inhibit acetylcholinesterase (AChE), leading to overstimulation of muscarinic receptors. Both GB and PB produce miosis through stimulation of ocular muscarinic receptors. This study investigated 2 hypotheses: (1) that the miotic response to PB would decrease following repeated injections; and (2) that repeated administration of PB would result in tolerance to the miotic effect of GB vapor. Rats were injected intramuscularly with saline, 0.04 mg/kg, 0.5 mg/kg, or 1.4 mg/kg of PB twice daily for 8 consecutive days. After day 3, animals injected with 1.4 mg/kg PB developed miotic tolerance. Twenty-four (24) h following the final PB injection, the rats were exposed to GB vapor (4.0 mg/m(3)). A similar magnitude of miosis was observed in all groups after GB exposure. However, the rate of recovery of pupil size in animals pretreated with 0.5 and 1.4 mg/kg PB was significantly increased. Twenty (20) h following exposure to GB vapor, the pupils of animals pretreated with 1.4 mg/kg PB had recovered to 77% -t 4% of their pre-exposure baseline, whereas the saline-injected controls had recovered to only 52% +/- 2% of their pre-exposure baseline. The increased rate of recovery does not appear to be a result of protection of pupillary muscarinic receptors by the higher doses of PB, as there was no longer PB present in the animal at the time of GB exposure. These results demonstrate the development of tolerance to the miotic effect of PB following repeated exposures, and also suggest that cross-tolerance between PB and GB occurs. However, because the magnitude of the response was not reduced, the PB pretreatment and its associated miotic cross-tolerance does not appear to diminish the effectiveness of miosis as a biomarker of acute exposure to nerve agent vapor. C1 USA, Operat Toxicol Team, Edgewood Chem Biol Ctr, AMSRD,ECB,RTTT, Aberdeen Proving Ground, MD 21010 USA. SAIC Inc, Gunpowder, MD USA. RP Dabisch, PA (reprint author), USA, Operat Toxicol Team, Edgewood Chem Biol Ctr, AMSRD,ECB,RTTT, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM paul.a.dabisch@us.army.mil NR 23 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1080-7683 J9 J OCUL PHARMACOL TH JI J. Ocular Pharmacol. Ther. PD OCT PY 2006 VL 22 IS 5 BP 323 EP 332 DI 10.1089/jop.2006.22.323 PG 10 WC Ophthalmology; Pharmacology & Pharmacy SC Ophthalmology; Pharmacology & Pharmacy GA 101XR UT WOS:000241775100004 PM 17076626 ER PT J AU Woodman, RH Klotz, BR Kecskes, LJ AF Woodman, R. H. Klotz, B. R. Kecskes, L. J. TI Observation of incongruent melting in Cu10Hf7 SO JOURNAL OF PHASE EQUILIBRIA AND DIFFUSION LA English DT Article DE binary system; copper; differential thermal analysis; electron probe microanalysis; equilibrium diagram; experimental study; hafnium AB Differential thermal analysis, scanning electron microscopy, and x-ray microanalysis are used to show that the intermetallic compound Cu10Hf7, previously reported as melting congruently at 1025 degrees C, melts incongruently to CuHf2 and a Hf-Cu liquid at that temperature. A eutectic point previously reported at 43.6 at.% Hf and 980 degrees C does not exist. C1 AMSRD ARL WM MB, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM robw39@mindspring.com RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 4 TC 1 Z9 1 U1 0 U2 2 PU ASM INTERNATIONAL PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 1547-7037 J9 J PHASE EQUILIB DIFF JI J. Phase Equilib. Diffus. PD OCT PY 2006 VL 27 IS 5 BP 477 EP 481 DI 10.1361/154770306X132010 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 091QU UT WOS:000241044200007 ER PT J AU Ovcharenko, AA Bondarenko, SY Zubko, ES Shkuratov, YG Videen, G Nelson, RM Smythe, WD AF Ovcharenko, AA Bondarenko, SY Zubko, ES Shkuratov, YG Videen, G Nelson, RM Smythe, WD TI Particle size effect on the opposition spike and negative polarization SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE negative polarization; opposition effect; coherent backscattering; single-particle scattering ID OUTER PLANET SATELLITES; COHERENT BACKSCATTER; SPHERICAL-PARTICLES; LIGHT; SCATTERING; REGOLITHS; SURFACES AB We report results of experiments designed to increase our understanding of the influence of particle size on the photometric opposition spike and negative polarization observed in the reflectance and polarization phase curves of particulate surfaces. We concentrate our studies on particle-size separates of alumina (bright powders) and boron carbide (absorbing powders). We use two photopolarimeters that span small (0.2-17 degrees) and large (2-160 degrees) phase-angle ranges. The results suggest that the negative polarization has two dominant mechanisms: (1) the coherent-backscatter enhancement and (2) single-particle scatter, and that the contributions of the mechanisms are a function of particle size. The measured photometric and polarimetric phase functions can be applied to evaluate models used to calculate scattering properties of particulate surfaces. Published by Elsevier Ltd. C1 USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. Jet Prop Lab, Pasadena, CA 91101 USA. RP Videen, G (reprint author), USA, Res Lab, AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gvideem@arl.army.mil NR 32 TC 15 Z9 15 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2006 VL 101 IS 3 SI SI BP 394 EP 403 DI 10.1016/j.jqsrt.2006.02.036 PG 10 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 056VW UT WOS:000238554200003 ER PT J AU Zubko, E Shkuratov, Y Kiselev, NN Videen, G AF Zubko, Evgenij Shkuratov, Yuriy Kiselev, Nikolay N. Videen, Gorden TI DDA simulations of light scattering by small irregular particles with various structure SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE scatter; polarization; non-spherical particles ID DISCRETE-DIPOLE APPROXIMATION; POLARIZATION; AEROSOL; GRAINS AB We present DDA investigations of light scattering by irregular particles whose size is comparable with wavelength. We consider four types of randomly irregular particles: strongly damaged spheres, rough-surface spheres, pocked spheres, and agglomerated debris particles. Each type of particle is generated with a well defined algorithm producing an ensemble of stochastically different particles that have a common origin. The different types of irregular particles produce different angular dependencies of intensity and linear polarization degree. Transformation of phase curves of intensity and polarization with changing size parameter for irregular particles tends to be more monotonic, unlike spheres. We find that the magnitude of the negative polarization branch (NPB) tends to shrink as particle absorption increases; whereas, the maximal value and position of the positive polarization branch tends to increase. The most frequently observed shape of the negative polarization at small phase angles is asymmetric with a shift of the minimum position towards the angle of polarization sign inversion. All types of considered irregular particles reveal such asymmetry at x < 10. Symmetric negative polarization branches occur seldom. The necessary conditions for their appearance are a relatively large size parameter x >= 10 to 12 and low absorption. Published by Elsevier Ltd. C1 USA, Res Lab, AMSRL, CI EM, Adelphi, MD 20783 USA. Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRL, CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM zubko@astron.kharkov.ua; gvideen@arl.army.mil NR 12 TC 27 Z9 27 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2006 VL 101 IS 3 SI SI BP 416 EP 434 DI 10.1016/j.jqsrt.2006.02.055 PG 19 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 056VW UT WOS:000238554200006 ER PT J AU Ovcharenko, A Bondarenko, S Shkuratov, Y Scotto, C Merritt, C Hart, M Eversole, J Videen, G AF Ovcharenko, Andrey Bondarenko, Sergey Shkuratov, Yuriy Scotto, Cathy Merritt, Charles Hart, Matthew Eversole, Jay Videen, Gorden TI Backscatter effects of surfaces composed of dry biological particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE backscattering; opposition effect; biological particle ID NEGATIVE POLARIZATION; AGGLOMERATE PARTICLES AB We present the backscattering of particulate surfaces consisting of dry biological particles using two laboratory photopolarimeters that measure intensity and degree of linear polarization in a phase-angle range 0.2-60 degrees. We measure scattering properties from three samples composed of dry biological particles, Bacillus subtilis var. niger (BG) spores and samples of fungi Aspergillus terreus and Sporisorium cruentum spores. We find that the surfaces display a prominent brightness opposition effect and significant negative polarization near backscattering angles. The brightness and polarimetric phase curves are different for B. subtilis and the fungi. Published by Elsevier Ltd. C1 USA, Res Lab, AMSRL, CI EM, Adelphi, MD 20783 USA. Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. Natl Acad Sci Ukraine, Inst Radio Astron, UA-61002 Kharkov, Ukraine. USN, Res Lab, Washington, DC 20375 USA. RP Videen, G (reprint author), USA, Res Lab, AMSRL, CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ovcharenko@astron.kharkov.ua; gvideen@arl.army.mil NR 12 TC 6 Z9 6 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2006 VL 101 IS 3 SI SI BP 462 EP 470 DI 10.1016/j.jqsrt.2006.02.037 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 056VW UT WOS:000238554200009 ER PT J AU Grynko, Y Shkuratov, Y Videen, G AF Grynko, Y Shkuratov, Y Videen, G TI Polarization of near-forward-scattered light from particulate substrates illuminated at near-grazing angles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article ID POLARIMETRIC PROPERTIES; LUNAR SURFACE; PARTICLES AB Laboratory photopolarimetric measurements of light scattered by substrates consisting of semitransparent particles with sizes significantly larger than the wavelength show a polarization shoulder at small scattering angles near theta = 10-30 degrees in addition to the Brewster maximum positioned near theta = 50 degrees. With ray-tracing simulations, we find that the shoulder appears to be related to light passing through particles in the upper layers of the substrates. We study the dependence on particle absorption and packing density of particulate substrates. The studies show that the shoulder weakens with increased absorption and packing density. Published by Elsevier Ltd. C1 USA, Res Lab, AMSRL, CI EM, Hyattsville, MD 20783 USA. Max Planck Inst Aeron, D-37191 Katlenburg Duhm, Germany. Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRL, CI EM, 2800 Powder Mill Rd, Hyattsville, MD 20783 USA. EM shkuratov@vk.kh.ua; gvideen@arl.army.mil RI grynko, Yevgen/C-2266-2008 NR 11 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2006 VL 101 IS 3 SI SI BP 522 EP 526 DI 10.1016/j.jqsrt.2006.02.039 PG 5 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 056VW UT WOS:000238554200014 ER PT J AU Singh, MP Moreschi, LM Suarez, LE Matheu, EE AF Singh, M. P. Moreschi, L. M. Suarez, L. E. Matheu, E. E. TI Seismic design forces. I: Rigid nonstructural components SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article ID FLOOR ACCELERATION DEMANDS; MULTISTORY BUILDINGS; PERIOD FORMULAS AB The paper examines the seismic design force formulas that are currently prescribed in the 2003 NEHRP Provision for the design of nonstructural components in buildings, and presents new formulas to improve the these recommendations. The current code provisions are building independent and overly conservative, especially for the design of nonstructural components in tall buildings. This conservatism can be reduced by utilizing the information about the fundamental period of the building. New force formulas that depend on the building period are proposed. The proposed formulas are intended to avoid more involved analyses. They are validated by a comprehensive numerical study of several buildings of different periods analyzed for an ensemble of recorded earthquake acceleration time histories. C1 Virginia Tech, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. Bechtel Power Corp, Frederick, MD USA. Univ Puerto Rico, Dept Civil Engn, Mayaguez, PR USA. USA, Ctr Res & Dev, Vicksburg, MS USA. RP Singh, MP (reprint author), Virginia Tech, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. EM mpsingh@vt.edu NR 18 TC 17 Z9 17 U1 2 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD OCT PY 2006 VL 132 IS 10 BP 1524 EP 1532 DI 10.1061/(ASCE)0733-9445(2006)132:10(1524) PG 9 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 088CW UT WOS:000240790100003 ER PT J AU Singh, MP Moreschi, LM Suarez, LE Matheu, EE AF Singh, M. P. Moreschi, L. M. Suarez, L. E. Matheu, E. E. TI Seismic design forces. II: Flexible nonstructural components SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article ID SECONDARY SYSTEMS; GENERATION; BUILDINGS; SPECTRA AB This paper presents two simplified methods for calculating the seismic force coefficients for flexible nonstructural components in building structures. The methods utilize the dynamic characteristics, expressed in terms of the fundamental periods and damping ratios, of the component and the supporting structure to calculate the force coefficient. The cases with the building period and component period known or unknown are considered. The formulas with less information tend to provide more conservative estimates of the force to cover the worst case situations. The new formulas now include the effect of possible resonance with higher modes. The validity of the proposed formulas is verified by a comprehensive numerical study of several buildings of different fundamental periods. C1 Virginia Tech, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. Bechtel Power Corp, Frederick, MD USA. Univ Puerto Rico, Dept Civil Engn, Mayaguez, PR USA. USA, Ctr Res & Dev, Vicksburg, MS USA. RP Singh, MP (reprint author), Virginia Tech, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. EM mpsingh@vt.edu NR 15 TC 14 Z9 14 U1 2 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD OCT PY 2006 VL 132 IS 10 BP 1533 EP 1542 DI 10.1061/(ASCE)0733-9445(2006)132:10(1533) PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 088CW UT WOS:000240790100004 ER PT J AU Lever, JH Denton, D Phetteplace, GE Wood, SD Shoop, SA AF Lever, James H. Denton, Daniel Phetteplace, Gary E. Wood, Sumintra D. Shoop, Sally A. TI Mobility of a lightweight tracked robot over deep snow SO JOURNAL OF TERRAMECHANICS LA English DT Article DE over-snow mobility; Bekker; resistance; traction; robotic vehicle AB We designed and built a 24-kg tracked robot, named SnoBot, based on the performance of a 1400-kg manned vehicle scaled using Bekker mobility theory. We then documented the mobility of the robot for 10 cases of deep snow and four cases of shallow snow. The scaled predictions agreed well with average sinkage, resistance and traction measured in deep snow and thus gave useful design guidance. Nevertheless, large differences occurred between measured and predicted snow-compaction resistance on individual test days. The behavior of actual snow packs is difficult to capture using simple Bekker theory. Most deep-snow packs showed a linear relationship between pressure and sinkage for small indentation, followed by a steep rise in pressure as indentation compacted the snow against the ground. Also, small strength variations due to icy layers were important. SnoBot traveled easily over ice crusts that were much too weak to support foot travel. The results indicate that a lightweight tracked robot can display excellent deep-snow mobility when ground clearance, motor torque and energy storage allow for proportionally high sinkage and motion resistance compared with larger vehicles. Published by Elsevier Ltd on behalf of ISTVS. C1 USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. Dartmouth Coll, Hanover, NH 03755 USA. RP Lever, JH (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.h.lever@erdc.usace.army.mil NR 11 TC 12 Z9 12 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD OCT PY 2006 VL 43 IS 4 BP 527 EP 551 DI 10.1016/j.jterra.2005.09.002 PG 25 WC Engineering, Environmental SC Engineering GA 081MS UT WOS:000240322300009 ER PT J AU Lane, JE Walsh, DS Meyers, WM Klassen-Fischer, MK Kent, DE Cohen, DJ AF Lane, Joshua E. Walsh, Douglas S. Meyers, Wayne M. Klassen-Fischer, Mary K. Kent, David E. Cohen, David J. TI Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID DASYPUS-NOVEMCINCTUS; WILD ARMADILLOS; DISEASE; LOUISIANA; TEXAS AB In the southern and southeastern United States, the 9-banded armadillo is an important reservoir for Mycobacterium leprae, the causative agent of leprosy (Hansen's disease). Here, we describe a woman living in Georgia with borderline tuberculoid leprosy who worked for many years in a garden where armadillos burrowed or were buried. There was no history of foreign travel or known exposure to a person with leprosy. Treatment with 6 once-monthly combined doses of rifampin, ofloxacin, and minocycline was successful. C1 Mercer Univ, Sch Med, Dept Internal Med, Div Dermatol, Macon, GA 31217 USA. Mercer Univ, Sch Med, Dept Surg, Macon, GA 31217 USA. Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD USA. Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. RP Lane, JE (reprint author), Mercer Univ, Sch Med, Dept Internal Med, Div Dermatol, 308 Hosp Dr,Suite 200, Macon, GA 31217 USA. EM joshua.lane@iycos.com NR 16 TC 18 Z9 19 U1 0 U2 5 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 2006 VL 55 IS 4 BP 714 EP 716 DI 10.1016/j.jaad.2006.02.070 PG 3 WC Dermatology SC Dermatology GA 087OV UT WOS:000240752600025 PM 17010758 ER PT J AU Albrecht, MA Griffith, ME Murray, CK Chung, KK Horvath, EE Ward, JA Hospenthal, DR Holcomb, JB Wolf, SE AF Albrecht, Michael A. Griffith, Matthew E. Murray, Clinton K. Chung, Kevin K. Horvath, Edward E. Ward, John A. Hospenthal, Duane R. Holcomb, John B. Wolf, Steven E. TI Impact of Acinetobacter infection on the mortality of burn patients SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID RISK-FACTORS; MATCHED COHORT; BAUMANNII; BACTEREMIA; UNIT; PROGNOSIS; ACQUISITION; OUTBREAK AB BACKGROUND: Acinetobacter calcoaceticus-baumannii complex (Acb) is recognized as an important cause of nosocomial infections. Although Acb can be associated with multidrug resistance, its impact on mortality in burn patients has not been fully elucidated. STUDY DESIGN: In a retrospective cohort study assessing medical records and microbiology laboratory data at a US military tertiary care burn center, we evaluated all patients admitted to the burn center between January 2003 and November 2005. Data collected included age, severity of burn, comorbidities, length of stay, and survival to hospital discharge. In addition, microbiology data were reviewed to determine which patients were infected with Acb during this time frame. These data were then used to compare patients infected with Acb to patients not infected. Multivariate analysis using logistic regression was performed to determine which patient characteristics were associated with increased mortality. RESULTS: There were 802 patients included in the study. Fifty-nine patients met the case definition for infection. An additional 52 patients were found to be colonized with Acb. Patients with Acb infection had more severe burns and comorbidities, and had longer lengths of stay compared with patients without Acb or those with Acb colonization. Mortality in infected patients was higher compared with those without infection (relative risk = 2.86, p = 0.001). On multivariate analysis, infection with Acb was not statistically associated with mortality. CONCLUSIONS: Multidrug-resistant Acb is a common cause of nosocomial infection in the burn patient population. Despite this, it does not independently affect mortality. C1 Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78284 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 14 TC 60 Z9 63 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2006 VL 203 IS 4 BP 546 EP 550 DI 10.1016/j.jamcollsurg.2006.06.013 PG 5 WC Surgery SC Surgery GA 094YR UT WOS:000241275800018 PM 17000400 ER PT J AU Vorontsov, MA Carhart, GW AF Vorontsov, Mikhail A. Carhart, Gary W. TI Adaptive wavefront control with asynchronous stochastic parallel gradient descent clusters SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID PHASE-DISTORTION CORRECTION; OPTICS; OPTIMIZATION; RESOLUTION AB A scalable adaptive optics (AO) control system architecture composed of asynchronous control clusters based on the stochastic parallel gradient descent (SPGD) optimization technique is discussed. It is shown that subdivision of the control channels into asynchronous SPGD clusters improves the AO system performance by better utilizing individual and/or group characteristics of adaptive system components. Results of numerical simulations are presented for two different adaptive receiver systems based on asynchronous SPGD clusters-one with a single deformable mirror with Zernike response functions and a second with tip-tilt and segmented wavefront correctors. We also discuss adaptive wavefront control based on asynchronous parallel optimization of several local performance metrics-a control architecture referred to as distributed adaptive optics (DAO). Analysis of the DAO system architecture demonstrated the potential for significant increase of the adaptation process convergence rate that occurs due to partial decoupling of the system control clusters optimizing individual performance metrics. (c) 2006 Optical Society of America. C1 USA, Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. Univ Maryland, Syst Res Inst, Intelligent Opt Lab, College Pk, MD 20740 USA. RP Vorontsov, MA (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. EM Mvorontsov@arl.army.mil NR 16 TC 18 Z9 20 U1 3 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD OCT PY 2006 VL 23 IS 10 BP 2613 EP 2622 DI 10.1364/JOSAA.23.002613 PG 10 WC Optics SC Optics GA 089CU UT WOS:000240858500024 PM 16985545 ER PT J AU Eastridge, BJ Owsley, J Sebesta, J Beekley, A Wade, C Wildzunas, R Rhee, P Holcomb, J AF Eastridge, Brian J. Owsley, Jimmie Sebesta, James Beekley, Alec Wade, Charles Wildzunas, Robert Rhee, Peter Holcomb, John TI Admission physiology criteria after injury on the battlefield predict medical resource utilization and patient mortality SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 19th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 10-14, 2006 CL Orlando, FL SP Eastern Assoc Surg Trauma DE combat; war; resources; outcome; predict; blood; mortality ID OPERATION-IRAQI-FREEDOM; COMBAT CASUALTY CARE; EXPERIENCE; LESSONS; TRAUMA; SYSTEM AB Background: Medical resources and resource allocation including operating room and blood utilization are of prime importance in the modern combat environment. We hypothesized that easily measurable admission physiologic criteria and injury site as well as injury severity calculated after diagnostic evaluation or surgical intervention, would be strongly correlated with resource utilization and in theater mortality outcomes. Methods: We retrospectively reviewed the Joint Theater Trauma Registry for all battlefield casualties presenting to surgical component facilities during Operation Iraqi Freedom from January to July 2004. Data were collected from the composite population of 1,127 battlefield casualty patients with respect to demographics, mechanism, presentation physiology (blood pressure, heart rate, temperature), base deficit, admission hematocrit, Glasgow Coma Score (GCS), Injury Severity Score (ISS), operating room utilization, blood transfusion, and mortality. Univariate and multivariate analyses were conducted to determine the degree to which admission physiology and injury severity correlated with blood utilization, necessity for operation, and acute mortality. Results: Univariate analysis demonstrated a significant (p < 0.05) association between hypothermia (T < 34 degrees C) and the subsequent requirement for operation and mortality. In addition, the outcome variable total blood product utilization was significantly correlated with base deficit (r = 0.61), admission hematocrit (r = 0.51), temperature (r = 0.47), and ISS (r = 0.54). Using multiple logistic regression techniques, blood pressure, GCS, and ISS together demonstrated a significant association (p < 0.05) with mortality (area under ROC curve = 95%). Multiple linear regression established that blood pressure, heart rate, temperature, hematocrit, and ISS had a collective significant effect (p < 0.05) on total blood product utilization explaining 67% of the variance in this outcome variable. Conclusion: Admission physiology and injury characteristics demonstrate a strong capacity to predict resource utilization in the contemporary battlefield environment. In the future, such predictive yield could potentially have significant implications for triage and medical logistics in the resource constrained environment of war and potentially in mass casualty and disaster incidents in the civilian trauma setting which will likely have mechanistic similarity with war related injury. C1 USA, Inst Surg Res, MCHE SDI, Ft Sam Houston, TX 78234 USA. Martin Army Community Hosp, Dept Surg, Ft Benning, GA USA. Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. USN, Trauma Training Ctr, Los Angeles, CA USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, MCHE SDI, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 18 TC 25 Z9 26 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2006 VL 61 IS 4 BP 820 EP 823 DI 10.1097/01.ta.0000239508.94330.7a PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 096YU UT WOS:000241413700011 PM 17033546 ER PT J AU King, DR Patel, MB Feinstein, AJ Earle, SA Topp, RF Proctor, KG AF King, David R. Patel, Mayur B. Feinstein, Ara J. Earle, Steven A. Topp, Raymond F. Proctor, Kenneth. G. TI Simulation training for a mass casualty incident: Two-year experience at the army trauma training center SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE mass casualty; terrorism; disaster; training ID OPERATION-IRAQI-FREEDOM; SURGICAL-TEAM; US ARMY; AFGHANISTAN; FUTURE; SYSTEM; CARE AB Background. Civilian and military mass casualty incidents (MCI) are an unfortunate reality in the 21st century, but there are few situational training exercises (STX) to prepare for them. To rill this gap, we developed a MCI STX for U.S. Army Forward Surgical Teams (FST) in conjunction with the U.S. Army Trauma Training Center. Methods: After a standardized briefing, each FST has 60 minutes to unpack, setup, and organize a standard equipment cache into an emergency room, operating room, and intensive care unit. In an adjacent room. five anesthetized swine are prepared with standardized, combat-relevant injuries. The number and acuity of the total casualties are unknown to the FST and arrive in waves and without warning. A realistic combat environment is simulated by creating resource limitations, power outages, security breaches, and other stressors. The STX concludes when all casualties have died or are successfully treated. FSTs complete a teamwork self-assessment card, while staff and FST surgeons evaluate organization, resource allocation, communication, treatment, and overall performance. Feedback from each FST can he incorporated into an updated design for the next STX. Results: From 2003-2005, 16 FSTs have completed the STX. All FSTs have had collapses in situational triage, primary/secondary surveys, and/or ATLS principles (basic ABCs), resulting in approximately 20% preventable deaths. Conclusions:We concluded (1) a MCI can overwhelm even combat-experienced FSTs; (2) adherence to basic principles of emergency trauma care by all FST members is essential to effectively and efficiently respond to this MCI; (3) by prospectively identifying deficiencies, future military or civilian performance during an actual MCI may be improved; and (4) this MCI STX could provide a template for similar programs to develop, train, and evaluate civilian surgical disaster response teams. C1 Univ Miami, Div Trauma, DeWitt Daughtry Family Dept Surg, Miller Sch Med,Ryder Trauma Ctr, Miami, FL 33136 USA. Univ Miami, Div Surg Crit Care, DeWitt Daughtry Family Dept Surg, Miller Sch Med, Miami, FL 33136 USA. Jackson Mem Hosp, USA, Trauma Training Ctr, Ryder Trauma Ctr, Miami, FL 33136 USA. RP Proctor, KG (reprint author), Univ Miami, Div Trauma, DeWitt Daughtry Family Dept Surg, Miller Sch Med,Ryder Trauma Ctr, 1800 NW 10th Ave, Miami, FL 33136 USA. EM kproctor@miami.edu RI Patel, Mayur/K-2363-2013; OI King, David/0000-0003-1028-1478; Feinstein, Ara/0000-0001-6214-5334 FU NIGMS NIH HHS [T32 GM08749-01] NR 15 TC 19 Z9 21 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2006 VL 61 IS 4 BP 943 EP 948 DI 10.1097/01.ta.0000233670.97515.3a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 096YU UT WOS:000241413700033 PM 17033566 ER PT J AU Simmons, M Porter, KR Hayes, CG Vaughn, DW Putnak, R AF Simmons, Monika Porter, Kevin R. Hayes, Curtis G. Vaughn, David W. Putnak, Robert TI Characterization of antibody responses to combinations of a dengue virus type 2 DNA vaccine and two dengue virus type 2 protein Vaccines in rhesus macaques SO JOURNAL OF VIROLOGY LA English DT Article ID PROTECTIVE EFFICACY; NEUTRALIZING ANTIBODY; INFECTION; IMMUNOGENICITY; MICE; VOLUNTEERS; SEROTYPE; MONKEYS; DISEASE; MECHANISMS AB We evaluated three nonreplicating dengue virus type 2 (DENV-2) vaccines: (i) a DNA vaccine containing the prM-E gene region (D), (ii) a recombinant subunit protein vaccine containing the B domain (i.e., domain 111) of the E protein as a fusion with the Escherichia coli maltose-binding protein (R), and (iii) a purified inactivated virus vaccine (P). Groups of four rhesus macaques each were primed once and boosted twice using seven different vaccination regimens. After primary vaccination, enzyme-linked immunosorbent assay (ELISA) antibody levels increased most rapidly for groups inoculated with the P and DP combination, and by 1 month after the second boost, ELISA titers were similar for all groups. The highest plaque reduction neutralization test (PRNT) titers were seen in those groups that received the DR/DR/DR combination (geometric mean titer [GMT], 510), the P/P/P vaccine (GMT, 345), the DP/DP/DP combination (GMT, 287), and the R/R/R vaccine (GMT, 200). The next highest titers were seen in animals that received the D/R/R vaccine (GMT, 186) and the D/P/P vaccine (GMT, 163). Animals that received the D/D/D vaccine had the lowest neutralizing antibody titer (GMT, 49). Both ELISA and PRNT titers declined at variable rates. The only significant protection from viremia was observed in the P-vaccinated animals (mean of 0.5 days), which also showed the highest antibody concentration, including antibodies to NS1, and highest antibody avidity at the time of challenge. C1 Natl Naval Med Ctr, Dept Virus Dis, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA. RP Simmons, M (reprint author), Natl Naval Med Ctr, Dept Virus Dis, Silver Spring, MD 20910 USA. EM simmonsm@nmrc.navy.mil NR 31 TC 60 Z9 64 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 2006 VL 80 IS 19 BP 9577 EP 9585 DI 10.1128/JVI.00284-06 PG 9 WC Virology SC Virology GA 086BD UT WOS:000240647200021 PM 16973561 ER PT J AU Tang, J Murtadha, M Schnell, M Eisenlohr, LC Hooper, J Flomenberg, P AF Tang, Jie Murtadha, Mariam Schnell, Matthias Eisenlohr, Laurence C. Hooper, Jay Flomenberg, Phyllis TI Human T-cell responses to vaccinia virus envelope proteins SO JOURNAL OF VIROLOGY LA English DT Article ID ANTIGEN-PRESENTING CELLS; OUTER-MEMBRANE PROTEINS; CD40-ACTIVATED B-CELLS; 2 INFECTIOUS FORMS; SMALLPOX VACCINE; POXVIRUS CHALLENGE; NONHUMAN-PRIMATES; IMMUNE GLOBULIN; TRANSGENIC MICE; PROTECTS MICE AB One approach for a safer smallpox vaccine is to utilize recombinant subunits rather than live vaccinia virus (VACV). The products of the VACV envelope genes A27L, LIR, B5R, and A33R induce protective antibodies in animal models. We propose that proteins that elicit T-cell responses, as well as neutralizing antibodies, will be important to include in a molecular vaccine. To evaluate VACV-specific memory T-cell responses, peripheral blood mononuclear cells (PBMC) from four VACV vaccinees were tested against whole VACV and the individual envelope proteins A27, B5, L1, and A33, using gamma interferon enzyme-linked immunospot and cytokine flow cytometry assays. PBMC were stimulated with autologous dendritic cells infected with VACV or electroporated with individual VACV protein mRNAs. T-cell lines from all donors, vaccinated from I month to over 20 years ago, recognized all four VACV envelope proteins. Both CD4(+) and CD8(+) T-cell responses to each protein were detected. Further analysis focused on representative proteins B5 and A27. PBMC from a recent vaccinee exhibited high frequencies of CD4(+) and CD8(+) T-cell precursors to both B5 (19.8 and 20%, respectively) and A27 (6.8 and 3.7%). In comparison, B5- and A27-specific T-cell frequencies ranged from 0.4 to 1.3% in a donor vaccinated 3 years ago. Multiple CD4(+) and CD8(+) T-cell epitopes were identified from both A27 and B5, using overlapping 15-mer peptides. These data suggest that all four VACV envelope proteins may contribute to protective immunity, not only by inducing antibody responses, but also by eliciting T-cell responses. C1 Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19107 USA. Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Flomenberg, P (reprint author), Thomas Jefferson Univ, Dept Med, 1020 Locust St,Rm 329, Philadelphia, PA 19107 USA. EM Phyllis.flomenberg@mail.tju.edu OI Hooper, Jay/0000-0002-4475-0415 FU NIAID NIH HHS [AI 059246, R21 AI059246] NR 46 TC 27 Z9 27 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 2006 VL 80 IS 20 BP 10010 EP 10020 DI 10.1128/JVI.00601-06 PG 11 WC Virology SC Virology GA 091RU UT WOS:000241046800010 PM 17005679 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The blog of war: Frontline dispatches from military bloggers in Iraq and Afghanistan. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 2006 VL 131 IS 16 BP 92 EP 92 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 091RW UT WOS:000241047000184 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The trials of Abu Ghraib: An eyewitness account of shame and honor. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 2006 VL 131 IS 16 BP 93 EP 93 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 091RW UT WOS:000241047000188 ER PT J AU Guerena-Burgueno, F Jongsakul, K Smith, BL Ittiverakul, M Chiravaratanond, O AF Guerena-Burgueno, Fernando Jongsakul, Krisada Smith, Bryan L. Ittiverakul, Mali Chiravaratanond, Orapan TI Rapid assessment of health needs and medical response after the tsunami in Thailand, 2004-2005 SO MILITARY MEDICINE LA English DT Article ID BANDA-ACEH; SURVIVORS; MELIOIDOSIS AB On December 26, 2004, an earthquake triggered a massive tsunami in the Indian Ocean, causing an estimated 183,172 deaths and 40,320 missing in 12 countries. In Thailand, six provinces (Krabi, Phang-Nga, Phuket, Ranong, Satun, and Trang) were affected. U.S. government agencies delivered emergency medical assistance from December 30, 2004, to January 6, 2005. A team from the Armed Forces Research Institute of Medical Sciences conducted a rapid health and needs assessment in southern Thailand. Twelve hospitals were referral centers for tsunami-related medical care. None of the hospitals had been damaged during the tsunami; all activated mass casualty plans. As of October 2005, 5,395 deaths were confirmed and 2,817 individuals were missing. The response of the Thai government to the tsunami was rapid and effective in mitigating the health consequences among survivors and helped prioritize public health interventions and the diversion of U.S. assistance to areas with greater need for international emergency humanitarian assistance. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Guerena-Burgueno, F (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 17 TC 1 Z9 2 U1 0 U2 7 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 SU 1 BP 8 EP 11 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 096ZK UT WOS:000241415400007 PM 17447613 ER PT J AU Chretien, JP Glass, JS Coldren, RC Noah, DL Hyer, RN Gaydos, JC Malone, JL AF Chretien, Jean-Paul Glass, Jonathan S. Coldren, Rodney C. Noah, Donald L. Hyer, Randall N. Gaydos, Joel C. Malone, Joseph L. TI Department of Defense Global Emerging Infections Surveillance and Response System Indian Ocean tsunami response SO MILITARY MEDICINE LA English DT Article AB The Department of Defense (DoD) Global Emerging Infections Surveillance and Response System (DoD-GEIS) identifies and addresses DoD vulnerabilities to emerging infections through a global network of partners. Following the Indian Ocean tsunami of December 26, 2004, DoD-GEIS facilitated the DoD medical response and coordination with the Centers for Disease Control and Prevention and the World Health Organization. DoD-GEIS partners in Southeast Asia (U.S. Naval Medical Research Unit 2, Jakarta, Indonesia; and Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand) rapidly conducted health assessments and established surveillance for communicable diseases that threatened survivors. Preexisting collaboration with the Centers for Disease Control and Prevention, the World Health Organization, and host countries was critical for the DoD-GEIS tsunami response. C1 Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. USN, Med Res Unit 2, Jakarta, Indonesia. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Off Assistant Secretary Def Hlth Affairs, Washington, DC 20301 USA. WHO, Alert & Response Operat & Civil Mil Liaison Act, CH-1211 Geneva, Switzerland. RP Chretien, JP (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013; OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 14 TC 8 Z9 8 U1 0 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 SU 1 BP 12 EP 14 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 096ZK UT WOS:000241415400008 PM 17447614 ER PT J AU Porter, WD AF Porter, William D. TI Imported malaria and conflict: 50 years of experience in the US military SO MILITARY MEDICINE LA English DT Article ID REPUBLIC-OF-KOREA; VIVAX MALARIA; UNITED-STATES; SOLDIERS; AFGHANISTAN; VIETNAM; SOMALIA AB Over the last 50 years, members of the U.S. military have faced the threat of malaria in diverse geographical locations and operational situations, resulting in considerable morbidity and mortality. However, because malaria may be transported out of endemic areas and into areas that are free of malaria, the threat does not end with redeployment. Since the Korean Conflict, outbreaks of imported malaria have followed every major deployment of U.S. military forces to malaria endemic areas. By examining unique aspects of these outbreaks through the years, many similarities can be drawn. Repeated observations demonstrate that preventive efforts are only effective at reducing the impact of imported malaria when commanders are informed about the risks of malaria. Commanders must also understand the preventive resources that are available while deployed, and the potential for morbidity and mortality from malaria. C1 USA, Med Corps, Ft Hood, TX 76544 USA. RP Porter, WD (reprint author), USA, Med Corps, Headquarters,1st Calvary Div,Bldg 28000, Ft Hood, TX 76544 USA. NR 29 TC 8 Z9 9 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 925 EP 928 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900001 PM 17076440 ER PT J AU Snyder, A Mancuso, J Aldous, W AF Snyder, Andrea Mancuso, James Aldous, Wade TI Summary of the 2004-2005 influenza season in the US Army Europe SO MILITARY MEDICINE LA English DT Article AB Influenza and other respiratory infections, the most common cause of acute infectious disease in U.S adults, are also the leading cause of outpatient illness and a major cause of infectious disease hospitalization in U.S. military personnel. Although respiratory disease control is improved, epidemics continue to occur, and respiratory disease in military trainees continues to exceed that in U.S. civilian adults. Overall, Department of Defense utilization of the trivalent inactivated vaccine was much lower than anticipated during the 2004-2005 season. The slow start to the 2004-2005 influenza season resulted in a low demand for influenza immunization by the medically high-risk beneficiary population of the Department of Defense. Surveillance for influenza during the 2004-2005 season in U.S. Army Europe reached unprecedented heights, testing and confirming more cases than in any previous year. C1 USA, Dept Environm & Occupat Hlth, Div Epidemiol, Ctr Hlth Promot & Prevent Med Europe, APO, AE 09180 USA. Landstuhl Reg Med Ctr, Dept Microbiol, APO, AE 09180 USA. RP Snyder, A (reprint author), USA, Dept Environm & Occupat Hlth, Div Epidemiol, Ctr Hlth Promot & Prevent Med Europe, CMR 402, APO, AE 09180 USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 929 EP 932 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900002 PM 17076441 ER PT J AU Murray, CK Reynolds, JC Boyer, DA Koops, MK de Car, DAV Zanders, TB Hospenthal, DR AF Murray, Clinton K. Reynolds, Joel C. Boyer, Douglas A. Koops, Maureen K. de Car, David A. Van Zanders, Thomas B. Hospenthal, Duane R. TI Development of a deployment course for graduating military internal medicine residents SO MILITARY MEDICINE LA English DT Article ID OPERATION-IRAQI-FREEDOM AB Graduates of military internal medicine residency programs are required to have the necessary knowledge and skills to function as internists, military physicians, and military medical leaders. The global war on terrorism has increased the role internists are playing in combat theaters as they fill multiple different military medical positions including battalion, brigade, and division surgeons as well as physicians in echelon I, II, and III medical facilities. Along with general internists, internal medicine subspecialists, pediatricians, and family physicians also fill these roles. Although internal medicine training provides a broad-based knowledge to care for adults, it does not provide significant training in combat casualty care, detainee health care, or environmental health. To overcome many of these perceived shortfalls, we developed the 3-day deployment course for graduating internal medicine residents outlined in this article. Through a combination of didactic and hands-on training, militarily relevant medical knowledge and skills necessary to function at echelon I and II levels of care were provided. Residents uniformly accepted the course with measurable increase in their fund of knowledge at the completion of the course. C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 933 EP 936 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900003 PM 17076442 ER PT J AU Brundage, JF Johnson, KE Lange, JL Rubertone, MV AF Brundage, John F. Johnson, Karen E. Lange, Jeffrey L. Rubertone, Mark V. TI Comparing the population health impacts of medical conditions using routinely collected health care utilization data: Nature and sources of variability SO MILITARY MEDICINE LA English DT Article ID DISEASE; BURDEN; SURVEILLANCE; POLICY AB Prevention activities are designed and resourced based on perceptions of the relative population health impacts of various conditions. We examined the nature and variability of rankings of "conditions" based on how they are defined and how their population health impacts are measured. The first listed diagnosis from all hospitalizations and ambulatory visits of U.S. service members during 2002 was used to rank conditions (as defined by two standard classification systems) using five different measures of population health impacts. Less than 10% of all conditions accounted for more than one-half of total population health impact, regardless of how conditions were defined or impacts measured. However, specific conditions with the largest impacts varied depending on the classification system and impact measure. Four groups of related conditions-acute musculoskeletal injuries, pregnancy-related conditions, respiratory infections, and mental disorders (including substance abuse)-accounted for disproportionately large impacts regardless of the measure. The identification of conditions with the largest population health impacts depends on the nature and degree of aggregation in defining conditions and the measure of impact. The findings are relevant to prevention planning and resourcing. C1 USA, Med Surveillance Act, Epidemiol & Dis Surveillance Directorate, Ctr Hlth Promot & Prevent Med, Washington, DC 20307 USA. RP Brundage, JF (reprint author), Delmarva Fdn, Easton, MD 21601 USA. NR 20 TC 6 Z9 6 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 937 EP 942 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900004 PM 17076443 ER PT J AU Liu, X Engel, C Kang, H Armstrong, DW AF Liu, Xian Engel, Charles, Jr. Kang, Han Armstrong, David W. TI Veterans and functional status transitions in older Americans SO MILITARY MEDICINE LA English DT Article CT Annual Meeting of the Population-Association-of-America CY APR 01-03, 2004 CL Boston, MA SP Populat Assoc Amer ID MORTALITY; HEALTH; POPULATIONS; PATHWAYS; PEOPLE AB Objectives: This research examines the relationship of veteran status with functional status transitions in older Americans. Methods: Data for this study come from the Survey of Asset and Health Dynamics among the Oldest Old. We use a structural multinomial logit model to decompose the effect of older veterans into the direct effect and the indirect effects via physical health conditions and mental disorders on functional status transitions. Results: Although there is no distinct association among those functionally independent at baseline, veteran status significantly impacts age-dependent transitions from functional dependence to other statuses. At age 85, the excess mortality and the lower level of functional resolution among functionally dependent veterans are considerable. Conclusions: Physical health is more important than mental health in transmitting the effect of veteran status on functional status transitions in functionally dependent persons. C1 Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Dept Vet Affairs, Environm Epidemiol Serv, Washington, DC 20420 USA. RP Liu, X (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Bldg 2,Room 3G04,6900 Georgia Ave NW, Washington, DC 20307 USA. FU NIA NIH HHS [R03AG20140-01] NR 29 TC 4 Z9 4 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 943 EP 949 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900005 PM 17076444 ER PT J AU Reeves, DL Bleiberg, J Roebuck-Spencer, T Cernich, AN Schwab, K Ivins, B Salazar, AM Harvey, SC Brown, FH Warden, D AF Reeves, Dennis L. Bleiberg, Joseph Roebuck-Spencer, Tresa Cernich, Alison N. Schwab, Karen Ivins, Brian Salazar, Andres M. Harvey, Sally C. Brown, Fred H., Jr. Warden, Deborah TI Reference values for performance on the Automated Neuropsychological Assessment Metrics V3.0 in an active duty military sample SO MILITARY MEDICINE LA English DT Article ID REACTION-TIME; BRAIN-INJURY AB The Automated Neuropsychological Assessment Metrics (ANAM) is a computerized measure of processing speed, cognitive efficiency, and memory. This study describes performance and psychometric properties of ANAM in an active duty, healthy military sample (N = 2,371) composed primarily of young (18-46 years) adult males. Rarely have neuropsychological reference values for use with individuals in the military been derived from a large, active duty military population, and this is the first computerized neuropsychological test battery with military-specific reference values. Although these results do not provide demographically corrected, formal normative data, they provide reference points for neuropsychologists and other health care providers who are using ANAM data in research or clinical settings, with patients of comparable demographics to the present sample. C1 ClinVest Inc, Springfield, MO 65807 USA. Natl Rehabil Hosp, Ctr Cognit Neurosci, Washington, DC 20010 USA. Univ Maryland, Med Ctr, Dept Neurol, Baltimore, MD 21201 USA. Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20012 USA. Oncovir Inc, Washington, DC 20008 USA. 902nd Mil Intelligence Grp, Ft George G Meade, MD 20755 USA. Psychol Applicat Directorate, Special Operat Command, Ft Bragg, NC 28310 USA. RP Reeves, DL (reprint author), ClinVest Inc, 3805 S Kansas Expressway, Springfield, MO 65807 USA. NR 19 TC 27 Z9 27 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 982 EP 994 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900012 PM 17076451 ER PT J AU Wright, J Albright, TS Gehrich, AP Dunlow, SG Lettieri, CF Buller, JL AF Wright, Johnnie, Jr. Albright, Todd S. Gehrich, Alan P. Dunlow, Susan G. Lettieri, Christine F. Buller, Jerome L. TI Sexually transmitted diseases in Operation Iraqi Freedom/Operation Enduring Freedom SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY OCT 17-20, 2004 CL San Diego, CA SP Amer Coll Obstet & Gynecologists, Armed Forces Dist ID PERSIAN-GULF-WAR; CHLAMYDIA; MILITARY AB Objective: To identify the incidence of sexually transmitted diseases (STDs) in a female active duty population deployed in support of Operation Iraqi Freedom/Operation Enduring Freedom was the objective of this study. Methods: Retrospective chart review was completed on all soldiers seeking outpatient gynecologic care at Camp Doha, Kuwait, from September 2003 through March 2004. Descriptive statistical analysis was performed on data from all patients identified as having an STD. Results: Forty-four soldiers (2.5% of all encounters) were diagnosed with STDs during the study period. Genital herpes, Condyloma acuminata, and chlamydia were the most commonly identified infections accounting for 30, 25, and 21% of the diagnoses, respectively. Conclusion: Transmission of STDs in the deployed environment continues to be problematic. Viral infections were more commonly encountered than were bacterial infections. Patient education and prevention should be emphasized. Consideration should be given to STD, screening upon redeployment. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. DeWitt Army Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA. RP Wright, J (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. NR 12 TC 7 Z9 10 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 1024 EP 1026 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900020 PM 17076459 ER PT J AU Baechler, MF Kim, DH AF Baechler, Martin Frederick Kim, David H. TI "Uncoverage" of the humeral head by the anterolateral acromion and its relationship to full-thickness rotator cuff tears SO MILITARY MEDICINE LA English DT Article ID IMPINGEMENT SYNDROME; SHOULDER; DISEASE AB The relationship between the humeral head and the anterolateral acromion was compared for subjects with and without full-thickness rotator cuff tears, as indicated by magnetic resonance imaging, using a case-control design. "Uncoverage" of the humeral head by the anterolateral acromion was defined as the percentage of the humeral head width not covered superiorly by the anterolateral acromion, as measured digitally on magnetic resonance imaging scans of the shoulder in the oblique coronal plane. The uncoverage of the humeral head by the anterolateral acromion was 32.0% for men >= 40 years of age with normal rotator cuffs (n = 39) and 38.2% for men >= 40 years of age with full-thickness rotator cuff tears (n = 43). The difference in uncoverage of 6.2% was statistically significant (p < 0.001). The uncoverage of the humeral head by the anterolateral acromion was 36.1% for women >= 40 years of age with normal rotator cuffs (n = 10) and 41.8% for women >= 40 years of age with full-thickness rotator cuff tears (n = 17). The difference in uncoverage of 5.72% was not statistically significant with the number of subjects available (p = 0.108). We concluded that increased uncoverage of the humeral head by the anterolateral acromion may be a factor in the pathogenesis of full-thickness rotator cuff tears. C1 Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. Colorado Permanente Med Grp, Denver, CO 80205 USA. RP Baechler, MF (reprint author), Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. NR 8 TC 2 Z9 2 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2006 VL 171 IS 10 BP 1035 EP 1038 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 096JH UT WOS:000241372900022 PM 17076461 ER PT J AU Curtin, BF Pal, N Gordon, RK Nambiar, MP AF Curtin, Bryan F. Pal, Nabaneeta Gordon, Richard K. Nambiar, Madhusoodana P. TI Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE acetylcholinesterase; organophosphates; transcriptional regulators; neuronal cell lines; gene expression; neuroprotection ID SIGNALING PATHWAYS; CYCLIC-AMP; KINASE-A; NEUROBLASTOMA-CELLS; DIFFERENTIATION; TOXICITY; MYOTUBES; CULTURES; DODECYLGLYCEROL; PROLIFERATION AB Bioscavenger prophylactic therapy using purified human acetylcholinesterase (AChE) or butylcholinesterase (BChE) is a promising treatment for future protection against chemical warfare nerve agent exposure. Potential immune response due to the complex structure of cholinesterases, mutations, post-translational modifications, and genetic variation is a limiting factor against purified enzyme therapy. We investigated an alternative bioscavenger approach using Forskolin, an inducer of intracellular cyclic AMP (cAMP), which activates AChE promoter and up-regulates its expression. A mouse neuronal cell line, Neuro 2A, was treated with various doses of Forskolin and analysis of the expressed enzyme indicates that the AChE activity was significantly increased in cells exposed to repeated administration of the drug every other day for 7-10 days. Cholinesterase enzyme assays showed that the enzyme activity was increased approximately 2-fold for the extracellular enzyme and 3-fold for the intracellular enzyme. The optimal dose found for extracellular enzyme production was 12-24 mu M Forskolin, while the optimal dose for intracellular was 12 mu M. In parallel with the rise in the AChE level, the morphology of Forskolin-treated cells showed neurite growth with increasing doses. Forskolin treatment protects Neuro 2A cells from Diisopropylflurophophate (DFP), a surrogate of the organophosphate chemical warfare agents soman and sarin, induced toxicity in Neuro 2A cells. These results indicate that transcriptional inducers, such as Forskolin, can sufficiently up-regulate cellular AChE production and protect cells against organophosphate toxicity. C1 Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@na.amedd.army.mil NR 46 TC 12 Z9 12 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0300-8177 J9 MOL CELL BIOCHEM JI Mol. Cell. Biochem. PD OCT PY 2006 VL 290 IS 1-2 BP 23 EP 32 DI 10.1007/s11010-005-9084-4 PG 10 WC Cell Biology SC Cell Biology GA 088HF UT WOS:000240802100004 PM 16924422 ER PT J AU Kobeissy, FH Ottens, AK Zhang, ZQ Liu, MC Denslow, ND Dave, JR Tortella, FC Hayes, RL Wang, KKW AF Kobeissy, Firas H. Ottens, Andrew K. Zhang, Zhiqun Liu, Ming Cheng Denslow, Nancy D. Dave, Jitendra R. Tortella, Frank C. Hayes, Ronald L. Wang, Kevin K. W. TI Novel differential neuroproteomics analysis of traumatic brain injury in rats SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID SPECTRIN BREAKDOWN PRODUCTS; TANDEM MASS-SPECTROMETRY; STROKE-PRONE RATS; BIOMARKER DISCOVERY; PROTEOMIC IDENTIFICATION; CEREBROSPINAL-FLUID; SHOTGUN PROTEOMICS; HEAD-INJURY; CELL-DEATH; PROTEINS AB Approximately two million traumatic brain injury (TBI) incidents occur annually in the United States, yet there are no specific therapeutic treatments. The absence of brain injury diagnostic endpoints was identified as a significant roadblock to TBI therapeutic development. To this end, our laboratory has studied mechanisms of cellular injury for biomarker discovery and possible therapeutic strategies. In this study, pooled naive and injured cortical samples (48 h postinjury; rat controlled cortical impact model) were processed and analyzed using a differential neuroproteomics platform. Protein separation was performed using combined cation/anion exchange chromatography-PAGE. Differential proteins were then trypsinized and analyzed with reversed-phase LC-MSMS for protein identification and quantitative confirmation. The results included 59 differential protein components of which 21 decreased and 38 increased in abundance after TBI. Proteins with decreased abundance included collapsin response mediator protein 2 (CRMP-2), glyceraldehyde-3-phosphate dehydrogenase, microtubule-associated proteins MAP2A/2B, and hexokinase. Conversely C-reactive protein, transferrin, and breakdown products of CRMP-2, synaptotagmin, and alpha II-spectrin were found to be elevated after TBI. Differential changes in the above mentioned proteins were confirmed by quantitative immunoblotting. Results from this work provide insight into mechanisms of traumatic brain injury and yield putative biochemical markers to potentially facilitate patient management by monitoring the severity, progression, and treatment of injury. C1 Univ Florida, Dept Psychiat, Ctr Neuroproteom & Biomarkers Res, Gainesville, FL 32610 USA. Univ Florida, Ctr Traumat Brain Injury Studies, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA. Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. Univ Florida, Dept Biochem & Mol Biol, Gainesville, FL 32611 USA. Walter Reed Army Inst Res, Dept Neuropharmacol & Mol Biol, Div Neurosci, Silver Spring, MD 20910 USA. RP Kobeissy, FH (reprint author), Univ Florida, Dept Psychiat, Ctr Neuroproteom & Biomarkers Res, POB 100256, Gainesville, FL 32610 USA. EM firasko@ufl.edu; aottens@mbi.ufl.edu; kwang@psychiatry.ufl.edu RI Ottens, Andrew/K-3352-2012; kobeissy, firas/E-7042-2017; OI kobeissy, firas/0000-0002-5008-6944; Wang, Kevin/0000-0002-9343-6473 FU NINDS NIH HHS [R01 NS049175, R01 NS39091, R01 NS40182] NR 45 TC 89 Z9 93 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD OCT PY 2006 VL 5 IS 10 BP 1887 EP 1898 DI 10.1074/mcp.M600157-MCP200 PG 12 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 098KL UT WOS:000241519300016 PM 16801361 ER PT J AU Rudin, S Reinecke, TL Bayer, M AF Rudin, S. Reinecke, T. L. Bayer, M. TI Temperature dependence of optical linewidth in single InAs quantum dots SO PHYSICAL REVIEW B LA English DT Article ID ELASTIC GUIDED-WAVES; PLATES AB We consider the temperature dependence of the exciton linewidth in single InAs self-assembled quantum dots. We show that in cases where etched mesas are used to isolate the dots, the magnitude of the linear temperature coefficient and its dependence on mesa size are described well by exciton scattering by acoustic phonons whose lifetimes are given by phonon scattering from the mesa interfaces. This work shows that phonon scattering at interfaces and surfaces typically present in quantum dot structures can be important in dynamical processes in quantum dot systems. C1 USA, Res Lab, Adelphi, MD 20783 USA. USN, Res Lab, Washington, DC 20375 USA. Univ Dortmund, D-44221 Dortmund, Germany. RP Rudin, S (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 30 TC 24 Z9 24 U1 0 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD OCT PY 2006 VL 74 IS 16 AR 161305 DI 10.1103/PhysRevB.74.161305 PG 4 WC Physics, Condensed Matter SC Physics GA 101FC UT WOS:000241723700011 ER PT J AU Aubert, B Barate, R Bona, M Boutigny, D Couderc, F Karyotakis, Y Lees, JP Poireau, V Tisserand, V Zghiche, A Grauges, E Palano, A Chen, JC Qi, ND Rong, G Wang, P Zhu, YS Eigen, G Ofte, I Stugu, B Abrams, GS Battaglia, M Brown, DN Button-Shafer, J Cahn, RN Charles, E Gill, MS Groysman, Y Jacobsen, RG Kadyk, JA Kerth, LT Kolomensky, YG Kukartsev, G Lynch, G Mir, LM Oddone, PJ Orimoto, TJ Pripstein, M Roe, NA Ronan, MT Wenzel, WA del Amo Sanchez, P Barrett, M Ford, KE Harrison, TJ Hart, AJ Hawkes, CM Morgan, SE Watson, AT Goetzen, K Held, T Koch, H Lewandowski, B Pelizaeus, M Peters, K Schroeder, T Steinke, M Boyd, JT Burke, JP Cottingham, WN Walker, D Cuhadar-Donszelmann, T Fulsom, BG Hearty, C Knecht, NS Mattison, TS McKenna, JA Khan, A Kyberd, P Saleem, M Sherwood, DJ Teodorescu, L Blinov, VE Bukin, AD Druzhinin, VP Golubev, VB Onuchin, AP Serednyakov, SI Skovpen, YI Solodov, EP Todyshev, KY Best, DS Bondioli, M Bruinsma, M Chao, M Curry, S Eschrich, I Kirkby, D Lankford, AJ Lund, P Mandelkern, M Mommsen, RK Roethel, W Stoker, DP Abachi, S Buchanan, C Foulkes, SD Gary, JW Long, O Shen, BC Wang, K Zhang, L Hadavand, HK Hill, EJ Paar, HP Rahatlou, S Sharma, V Berryhill, JW Campagnari, C Cunha, A Dahmes, B Hong, TM Kovalskyi, D Richman, JD Beck, TW Eisner, AM Flacco, CJ Heusch, CA Kroseberg, J Lockman, WS Nesom, G Schalk, T Schumm, BA Seiden, A Spradlin, P Williams, DC Wilson, MG Albert, J Chen, E Dvoretskii, A Hitlin, DG Narsky, I Piatenko, T Porter, FC Ryd, A Samuel, A Andreassen, R Mancinelli, G Meadows, BT Sokoloff, MD Blanc, F Bloom, PC Chen, S Ford, WT Hirschauer, JF Kreisel, A Nauenberg, U Olivas, A Ruddick, WO Smith, JG Ulmer, KA Wagner, SR Zhang, J Chen, A Eckhart, EA Soffer, A Toki, WH Wilson, RJ Winklmeier, F Zeng, Q Altenburg, DD Feltresi, E Hauke, A Jasper, H Petzold, A Spaan, B Brandt, T Klose, V 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TI Search for the decay of a B-0 or (B)over-bar(0) meson to (K)over-bar(*0)K(0) or K-*0(K)over-bar(0) SO PHYSICAL REVIEW D LA English DT Article ID PHYSICS; JETS AB We present a search for the decay of a B-0 or (B) over bar (0) meson to a (K) over bar K-*0(0) or K-*0(K) over bar (0) final state, using a sample of approximately 232x10(6) B (B) over bar events collected with the BABAR detector at the PEP-II asymmetric energy e(+)e(-) collider at SLAC. The measured branching fraction is B(B-0 ->(K) over bar K-*0(0))+B(B-0 -> K-*0(K) over bar (0))=(0.2(-0.8-0.3)(+0.9+0.1))x10(-6). We obtain the following upper limit for the branching fraction at 90% confidence level: B(B-0 ->(K) over bar K-*0(0))+B(B-0 -> K-*0(K) over bar (0))< 1.9x10(-6). We use our result to constrain the standard model prediction for the deviation of the CP asymmetry in B-0 ->phi K-0 from sin2 beta. C1 Phys Particules Lab, F-74941 Annecy Le Vieux, France. Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain. 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Univ Liverpool, Liverpool L69 7ZE, Merseyside, England. Queen Mary Univ London, London E1 4NS, England. Univ London Royal Holloway & Bedford New Coll, Egham TW20 0EX, Surrey, England. Univ Louisville, Louisville, KY 40292 USA. Univ Manchester, Manchester M13 9PL, Lancs, England. Univ Maryland, College Pk, MD 20742 USA. Univ Massachusetts, Amherst, MA 01003 USA. MIT, USA, Nucl Sci Lab, Cambridge, MA 02139 USA. McGill Univ, Montreal, PQ H3A 2T8, Canada. Univ Milan, Dipartimento Fis, I-20133 Milan, Italy. Ist Nazl Fis Nucl, I-20133 Milan, Italy. Univ Mississippi, University, MS 38677 USA. Univ Montreal, Montreal, PQ H3C 3J7, Canada. Mt Holyoke Coll, S Hadley, MA 01075 USA. Univ Naples Federico II, Dipartimento Sci Fis, I-80126 Naples, Italy. Ist Nazl Fis Nucl, I-80126 Naples, Italy. NIKHEF H, Natl Inst Nucl Phys & High Energy Phys, NL-1009 DB Amsterdam, Netherlands. Univ Notre Dame, Notre Dame, IN 46556 USA. Ohio State Univ, Columbus, OH 43210 USA. Univ Oregon, Eugene, OR 97403 USA. Univ Padua, Dipartimento Fis, I-35131 Padua, Italy. Ist Nazl Fis Nucl, I-35131 Padua, Italy. Univ Paris 06, Lab Phys Nucl & Hautes Energies, F-75252 Paris, France. Univ Paris 07, Lab Phys Nucl & Hautes Energies, F-75252 Paris, France. Univ Penn, Philadelphia, PA 19104 USA. Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy. Ist Nazl Fis Nucl, I-06100 Perugia, Italy. Univ Pisa, Dipartimento Fis, Scuola Normale Super Pisa, I-56127 Pisa, Italy. Ist Nazl Fis Nucl, I-56127 Pisa, Italy. Prairie View A&M Univ, Prairie View, TX 77446 USA. Princeton Univ, Princeton, NJ 08544 USA. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. Ist Nazl Fis Nucl, I-00185 Rome, Italy. Univ Rostock, D-18051 Rostock, Germany. Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England. CEA Saclay, DSM Dapnia, F-91191 Gif Sur Yvette, France. Univ S Carolina, Columbia, SC 29208 USA. Stanford Univ, Stanford, CA 94305 USA. Stanford Linear Accelerator Ctr, Stanford, CA 94309 USA. SUNY Albany, Albany, NY 12222 USA. Univ Tennessee, Knoxville, TN 37996 USA. Univ Texas, Austin, TX 78712 USA. Univ Texas, Richardson, TX 75083 USA. Univ Turin, Dipartimento Fis Sperimentale, I-10125 Turin, Italy. Ist Nazl Fis Nucl, I-10125 Turin, Italy. Univ Trieste, Dipartmento Fis, I-34127 Trieste, Italy. Ist Nazl Fis Nucl, I-34127 Trieste, Italy. Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain. Univ Victoria, Victoria, BC V8W 3P6, Canada. Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England. Univ Wisconsin, Madison, WI 53706 USA. Yale Univ, New Haven, CT 06511 USA. Phys Corpusculaire Lab, Clermont Ferrand, France. Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy. Univ Basilicata, I-85100 Potenza, Italy. RP Aubert, B (reprint author), Phys Particules Lab, F-74941 Annecy Le Vieux, France. RI M, Saleem/B-9137-2013; Peters, Klaus/C-2728-2008; Cavallo, Nicola/F-8913-2012; Saeed, Mohammad Alam/J-7455-2012; de Groot, Nicolo/A-2675-2009; Lista, Luca/C-5719-2008; Bellini, Fabio/D-1055-2009; Roe, Natalie/A-8798-2012; Neri, Nicola/G-3991-2012; Forti, Francesco/H-3035-2011; Rotondo, Marcello/I-6043-2012; Patrignani, Claudia/C-5223-2009; de Sangro, Riccardo/J-2901-2012; Lusiani, Alberto/A-3329-2016; Della Ricca, Giuseppe/B-6826-2013; Di Lodovico, Francesca/L-9109-2016; Pappagallo, Marco/R-3305-2016; Calcaterra, Alessandro/P-5260-2015; Frey, Raymond/E-2830-2016; Negrini, Matteo/C-8906-2014; Monge, Maria Roberta/G-9127-2012; Oyanguren, Arantza/K-6454-2014; Luppi, Eleonora/A-4902-2015; Calabrese, Roberto/G-4405-2015; Mir, Lluisa-Maria/G-7212-2015; Martinez Vidal, F*/L-7563-2014; Kolomensky, Yury/I-3510-2015; Lo Vetere, Maurizio/J-5049-2012; Grancagnolo, Sergio/J-3957-2015; Lusiani, Alberto/N-2976-2015; Morandin, Mauro/A-3308-2016 OI Peters, Klaus/0000-0001-7133-0662; Saeed, Mohammad Alam/0000-0002-3529-9255; Bellini, Fabio/0000-0002-2936-660X; Neri, Nicola/0000-0002-6106-3756; Forti, Francesco/0000-0001-6535-7965; Rotondo, Marcello/0000-0001-5704-6163; Patrignani, Claudia/0000-0002-5882-1747; de Sangro, Riccardo/0000-0002-3808-5455; Lusiani, Alberto/0000-0002-6876-3288; Della Ricca, Giuseppe/0000-0003-2831-6982; Di Lodovico, Francesca/0000-0003-3952-2175; Pappagallo, Marco/0000-0001-7601-5602; Calcaterra, Alessandro/0000-0003-2670-4826; Frey, Raymond/0000-0003-0341-2636; Cavoto, Gianluca/0000-0003-2161-918X; Barlow, Roger/0000-0002-8295-8612; Negrini, Matteo/0000-0003-0101-6963; Monge, Maria Roberta/0000-0003-1633-3195; Oyanguren, Arantza/0000-0002-8240-7300; Luppi, Eleonora/0000-0002-1072-5633; Calabrese, Roberto/0000-0002-1354-5400; Mir, Lluisa-Maria/0000-0002-4276-715X; Martinez Vidal, F*/0000-0001-6841-6035; Kolomensky, Yury/0000-0001-8496-9975; Lo Vetere, Maurizio/0000-0002-6520-4480; Grancagnolo, Sergio/0000-0001-8490-8304; Lusiani, Alberto/0000-0002-6876-3288; Morandin, Mauro/0000-0003-4708-4240 NR 32 TC 6 Z9 6 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0010 EI 2470-0029 J9 PHYS REV D JI Phys. Rev. D PD OCT PY 2006 VL 74 IS 7 AR 072008 DI 10.1103/PhysRevD.74.072008 PG 12 WC Astronomy & Astrophysics; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA 101FE UT WOS:000241723900014 ER PT J AU Taylor, SF Taylor, CL AF Taylor, Shawn F. Taylor, Charles L. TI Dengue fever with hemorrhagic features in a special forces soldier SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE dengue; military; febrile illness; tropical medicine ID VIRUS-VACCINE; CANDIDATE; INFECTION; TRAVELERS; DISEASE; PATIENT; PATHOGENESIS; ATTENUATION; VOLUNTEERS; SOMALIA AB Military operations are conducted in a variety of settings. Some settings provide significant U. S. resources for preventive, primary, urgent, and emergency or trauma care. Other operations consist of small numbers of personnel relying on limited internal, improvised, and/or host nation resources. Special Forces often conduct their missions in rural, austere, and remote settings with a small "medical footprint." Often the supported government has difficulty providing essential services, including medical care. To address this, U. S. Special Forces select and train highly motivated individuals to perform medical duties in an exceptionally austere environment devoid of resources. This case highlights those services and the medical decision-making process required to provide medical care to approach the standard of care in the United States. In this case, the affected individual had dengue fever. C1 Womack Army Med Ctr, Special Forces Grp Airborne 7, Ft Bragg, NC USA. Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC USA. RP Taylor, CL (reprint author), 2721 Mirror Lake Dr, Fayetteville, NC 28303 USA. EM casiztaylor@hotmail.com NR 57 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD OCT-DEC PY 2006 VL 10 IS 4 BP 494 EP 501 DI 10.1080/10903120600725983 PG 8 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 110RR UT WOS:000242396900014 PM 16997781 ER PT J AU Roberts, J McManus, J Harrison, B AF Roberts, Jake McManus, John Harrison, Benjamin TI Use of ultrasonography to avoid an unnecessary procedure in the prehospital combat environment: A case report SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE pneumothorax; ultrasound ID TRAUMATIC PNEUMOTHORAX; BEDSIDE ULTRASOUND; CHEST RADIOGRAPHY; DIAGNOSIS; RECOGNITION; EXPERIENCE; CARE AB The role of ultrasonography in the prehospital combat setting has become a useful tool for triage, diagnosis, and treatment. Recent literature has demonstrated that ultrasonography has a greater sensitivity and specificity than clinical examination and plain radiography for pneumothorax detection in trauma patients, particularly small pneumothoraces. This becomes especially critical in austere and remote environments. Although many pneumothoraces are initially considered non life- threatening, austere and combat environments possess additional risks of limited supplies, multiple casualties, and prolonged evacuation times that may potentially increase the morbidity of these injuries. This case report discusses the role of ultrasonography in pneumothorax detection in the prehospital combat environment. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP McManus, J (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 28 TC 11 Z9 12 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD OCT-DEC PY 2006 VL 10 IS 4 BP 502 EP 506 DI 10.1080/10903120600887023 PG 5 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 110RR UT WOS:000242396900015 PM 16997782 ER PT J AU Robbins, RG Bush, SE AF Robbins, Richard G. Bush, Sarah E. TI First report of Amblyomma papuanum Hirst (Acari : Ixodida : Ixodidae) from the Dwarf Cassowary, Casuarius bennetti Gould (Aves : Struthioniformes : Casuariidae), with additional records of parasitism of Casuarius spp. by this tick SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article C1 Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. Univ Kansas, Nat Hist Museum, Lawrence, KS 66045 USA. RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. EM richard.robbins@osd.mil; bush@biology.utah.edu NR 7 TC 1 Z9 1 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD OCT PY 2006 VL 108 IS 4 BP 1002 EP 1004 PG 3 WC Entomology SC Entomology GA 097LV UT WOS:000241450200030 ER PT J AU Trope, RL Power, EM AF Trope, Roland L. Power, E. Michael TI Training the spyglass: Law in anticipation of the hydrogen economy SO PROCEEDINGS OF THE IEEE LA English DT Article DE hydrogen economy; legal factors AB Despite its popularity as a "cure" for growing global energy needs, the "hydrogen economy" is decades away. In this paper, the authors consider the legal aspects of its possible development and extrapolate trends from recent events that may accelerate the arrival of the hydrogen economy, impediments that may delay its development, and the role laws and regulations might have in both. An attempt is made to address the various factors on a global scale while using specific examples to highlight the nature of the legal issues. The role of legislation is generally to follow society in the development of rules of conduct to address concerns or problems. To do otherwise and attempt to legislative specific courses of action tends to be economically inefficient, especially in directing the path for development and adoption of new technologies. Since a mature hydrogen economy is decades distant, the authors focus their discussion of the role of law in such an economy on the laws applicable to the "early adopters" of emerging hydrogen-related technologies. What surprisingly emerges is a discussion of such legal topics as export controls, patent laws applicable to government contracts and defence controls as well as environmental and energy regulatory regimes. C1 Trope & Schramm LLP, New York, NY 10017 USA. US Mil Acad, Dept Law, West Point, NY 10996 USA. Gowling Lafleur Henderson LLP, Ottawa, ON K1P 1C3, Canada. RP Trope, RL (reprint author), Trope & Schramm LLP, New York, NY 10017 USA. EM roland.trope@verizon.net; michael.power@gowlings.com NR 29 TC 0 Z9 0 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9219 J9 P IEEE JI Proc. IEEE PD OCT PY 2006 VL 94 IS 10 SI SI BP 1880 EP 1895 DI 10.1109/JPROC.2006.883714 PG 16 WC Engineering, Electrical & Electronic SC Engineering GA 115KT UT WOS:000242733900011 ER PT J AU Lettieri, CJ Nathan, SD Browning, RF Barnett, SD Ahmad, S Shorr, AF AF Lettieri, Christopher J. Nathan, Steven D. Browning, Robert F. Barnett, Scott D. Ahmad, Shahzad Shorr, Andrew F. TI The distance-saturation product predicts mortality in idiopathic pulmonary fibrosis SO RESPIRATORY MEDICINE LA English DT Article DE desaturation; idiopathic pulmonary fibrosis; mortality; pulmonary function tests; 6-min walk test ID 6-MINUTE WALK TEST; USUAL INTERSTITIAL PNEUMONIA; SURFACTANT PROTEIN-A; PROGNOSTIC-SIGNIFICANCE; COMPUTED-TOMOGRAPHY; LUNG-DISEASE; SURVIVAL; PATHOLOGISTS; HYPERTENSION; DIAGNOSIS AB Introduction: The 6-min walk test (6MWT) has prognostic value in various pulmonary disorders including idiopathic pulmonary fibrosis (IPF). We determined the individual prognostic accuracy of distance walked and oxygen saturation during the 6MWT in patients with IPF We defined a new composite index, the distance-saturation product (DSP), which is the product of distance walked and Lowest oxygen saturation during the 6-min walk test. We compared the performance of the DSP to the individual 6MWT parameters in predicting mortality. Methods: We evaluated pulmonary function tests, 6-min walk parameters and the DSP between survivors and non-survivors. The ability of each measure to discriminate outcomes was determined by receiver operator curves. Results: 81 patients (48 survivors, 33 non-survivors) were included. Pulmonary function tests were similar and did not correlate with survival. Desaturation was greater (89.4% versus 83.7%, P < 0.001) and distance walked was lower (406.9 versus 181.3 m, P = 0.005) in non-survivors. The DSP was significantly lower among non-survivors (364.8 versus 153.5 m%, P < 0.001) and predicted mortality more accurately than either individual 6MWT component (P = 0.035 versus desaturation, P = 0.040 versus distance). A DSP < 200 m% was associated with a seven-fold greater risk of 12-month mortality and an 18.0% shorter median survival compared with a DSP > 200 m% (P < 0.001). Discussion: Each component of the 6-min walk independently predicted mortality in IPF with greater accuracy than spirometry. However, a composite of both parameters, the DSP, provides slightly greater accuracy and represents a novel measure for assessing survival in patients with IPF. Published by Elsevier Ltd. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Inova Fairfax Hosp, Lung Transplant Program, Falls Church, VA USA. Washington Hosp Ctr, Washington, DC 20010 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil NR 31 TC 47 Z9 49 U1 0 U2 3 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 J9 RESP MED JI Respir. Med. PD OCT PY 2006 VL 100 IS 10 BP 1734 EP 1741 DI 10.1016/j.rmed.2006.02.004 PG 8 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 091PE UT WOS:000241040000007 PM 16545950 ER PT J AU Carroll, MH Clark, MD AF Carroll, Marjorie H. Clark, M. Diane TI Men's acquaintance rape scripts: A comparison between a regional university and a military academy SO SEX ROLES LA English DT Article DE acquaintance rape; scripts; civilian-military; social cognition; MIMIC model ID SEXUAL ASSAULT; SEDUCTION SCRIPTS; NATIONAL SAMPLE; COLLEGE-WOMEN; DATE RAPE; EXPERIENCES; BEHAVIORS; STUDENTS; RISK; ACKNOWLEDGMENT AB Men's acquaintance rape scripts were investigated to determine if background experiences impacted the type of script elicited. Men were selected from either a regional public university (n = 147) or a military academy (n = 283) to represent broad general background experiences. Overall, similarities in the five types of scripts elicited were evident, which are reflective of the cultural components that underlie men's expectations of what occurs in these situations. The influence of background experiences was noted in differences in both the frequency with which scripts were reported as well as the individual content of each script. Modeling analyses uncovered the latent structure for these differences. Suggestions for possible explanations for these differences, such as the role of traditional gender role attitudes, are discussed. C1 US Mil Acad, Dept Behav Sci & Leadership, Official Mail & Distribut Ctr, West Point, NY 10996 USA. Gallaudet Univ, Dept Educ Fdn & Res, Washington, DC 20002 USA. RP Carroll, MH (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Official Mail & Distribut Ctr, 946 Swift Rd, West Point, NY 10996 USA. EM marjorie.carroll@usma.edu NR 45 TC 7 Z9 7 U1 1 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0360-0025 J9 SEX ROLES JI Sex Roles PD OCT PY 2006 VL 55 IS 7-8 BP 469 EP 480 DI 10.1007/s11199-006-9102-3 PG 12 WC Psychology, Developmental; Psychology, Social; Women's Studies SC Psychology; Women's Studies GA 115AD UT WOS:000242705900004 ER PT J AU Walz, JM Convertino, VA Ryan, KL Soyemi, O Yang, Y Heard, SO Soller, BR AF Walz, J. Matthias Convertino, Victor A. Ryan, Kathy L. Soyemi, Olusola Yang, Ye Heard, Stephen O. Soller, Babs R. TI Intramuscular PO2 determined by near infrared spectroscopy is an early indicator of hemodynamic instability in a lower body negative pressure model of hemorrhagic shock. SO SHOCK LA English DT Meeting Abstract CT 12th Congress of the European-Shock-Society CY SEP 14-16, 2006 CL Ulm, GERMANY SP European Shock Soc, Univ Hosp Ulm, Div Surg Res, Dept Visceral & Transplantat Surg C1 Univ Massachusetts, Med Ctr, Dept Anesthesiol, Div Crit Care Med, Worcester, MA 01545 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2006 VL 26 SU 1 MA 51 BP 16 EP 17 DI 10.1097/00024382-200610001-00051 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 091JD UT WOS:000241022400052 ER PT J AU Martini, WZ Chinkes, DL Sondeen, J Dubick, MA AF Martini, Wenjun Z. Chinkes, David L. Sondeen, Jill Dubick, Michael A. TI Effects of hemorrhage and lactated Ringer's resuscitation on coagulation and fibrinogen metabolism in swine SO SHOCK LA English DT Article DE hemostasis; fibrinogen; stable isotopes; trauma; thromboelastography ID ACUTE-PHASE RESPONSE; OTHERWISE FATAL HEMORRHAGE; INDEPENDENT CONTRIBUTIONS; FLUID RESUSCITATION; COAGULOPATHY; SHOCK; TRAUMA; LIVER; ACID; HYPERCOAGULABILITY AB Hemorrhagic coagulopathy is a significant complication after traumatic injury, and much of the underlying mechanism remains unclear. We investigated the changes in fibrinogen metabolism and coagulation after a moderate hemorrhage and resuscitation. Pigs of either sex (weight, 40.9 +/- 0.8 kg) were anesthetized and instrumented with arterial and venous catheters and a thermodilution cardiac output catheter. Pigs were randomized into control (C; n = 6), hemorrhage (H; n = 6), and hemorrhage and resuscitation (H-LR; n = 6) groups. Hemorrhage was induced by bleeding 35% of total blood volume for 30 min in H and H-LR groups. Resuscitation in H-LR group was performed using lactated Ringers solution (LR) at 3 times the bled volume for 30 min. Fibrinogen metabolism was quantified using a primed constant infusion of 1-C-13-phenylalanine (6 h) and d(5)-phenylalanine (4 h) and subsequent analysis by gas chromatograph-mass spectrometry, together with measurements of hemodynamics (hourly) and coagulation by thromboelastography (at baseline and 4 h after hemorrhage and resuscitation). Hemorrhage caused decreases in arterial pH and base excess, and an increase in arterial lactate content. Fluid resuscitation corrected these changes toward normal levels. Fibrinogen level was unchanged in C and decreased to 76% +/- 4% in H and to 73% +/- 3% in H-LR (both P < 0.05, compared with baseline) after hemorrhage and resuscitation. Fibrinogen breakdown was increased from 3.0 +/- 0.4 mg kg(-1) h(-1) in C to 5.4 +/- 0.6 mg kg(-1) h(-1) in H and to 5.6 +/- 0.5 mg kg(-1) h(-1) in H-LR (both P < 0.05, compared with control), but synthesis was unchanged. The clotting reaction time was unchanged in C and shortened to 93% +/- 3% in H and to 91% +/- 1% in H-LR (both P < 0.05, compared with baseline). We conclude that hemorrhagic shock caused accelerated fibrinogen breakdown and coagulation. The LR resuscitation reduced tissue hypoxia indexes but did not affect the changes in fibrinogen metabolism and coagulation from hemorrhage. Thus, effective treatment of hemorrhage should include combining standard-of-care resuscitation with interventions to correct alterations in coagulation. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Med Branch, Galveston, TX 77550 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil NR 43 TC 29 Z9 30 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2006 VL 26 IS 4 BP 396 EP 401 DI 10.1097/01.shk.0000228169.86845.29 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 090CE UT WOS:000240927400013 PM 16980888 ER PT J AU Kayanja, MM Evans, K Milks, R Lieberman, IH AF Kayanja, Mark Makumbi Evans, Korboi Milks, Ryan Lieberman, Isador Harry TI Adjacent level load transfer following vertebral augmentation in the cadaveric spine SO SPINE LA English DT Article DE adjacent level load transfer; strain; stress; vertebral compression fracture; augmentation; biomechanics ID FINITE-ELEMENT; VERTEBROPLASTY; KYPHOPLASTY; FRACTURE; OSTEOPOROSIS; FAILURE; CEMENT; MODEL; RISK; BONE AB Study Design. In vitro biomechanics. Objective. To determine if osteoporotic vertebral compression fracture (VCF) augmentation increases adjacent level load transfer. Summary of Background Data. Osteoporotic VCF subsequent to augmentation may result from disease progression or increased adjacent level load transfer, or both. Methods. There were 11 T3-T7 and 10 T8-T12 divided by lumbar bone mineral density into a normal group (No. 1; n = 11) and an osteoporotic group (No. 2; n = 10). Strain and centrum stress were measured on T4 and T6 (T3-T7), and T9 and T11 (T8-T12) during tests in the intact state, following a centrum defect, during and after an augmented VCF at T5 or T10, and during a subsequent VCF. Stiffness and strength were compared: between groups 1 and 2; among intact, defect, and augmented VCF states; and between the initial and subsequent VCF. Results. Group 1 was stiffer than 2 in compression (P = 0.01) and flexion (P = 0.07), with no difference in adjacent level load transfer (strain P = 0.72, centrum stress P = 0.36) or strength (P = 0.07). The centrum defect reduced compressive stiffness from the intact (P = 0.001), which was partially restored following VCF augmentation (P = 0.006). There were no differences in flexion stiffness (P >= 0.14). Adjacent level load transfer in flexion exceeded that in compression (strain P = 0.001, centrum stress P = 0.19). Initial and subsequent VCF occurred at similar forces (P = 0.26) with higher adjacent level load at subsequent (strain and centrum stress P = 0.04). Conclusions. Augmentation of multilevel spinal segments with VCF produced by combined compression, flexion, and a centrum defect normalizes adjacent level load transfer at physiologic loads. In both normal and osteoporotic spinal segments, as loads approach those of the initial VCF, protection from augmentation is lost, and subsequent adjacent level VCFs occur from extreme loading, and not the augmentation process. C1 Cleveland Clin, Spine Res Lab W31, Spine Inst, Cleveland, OH 44195 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kayanja, MM (reprint author), Cleveland Clin, Spine Res Lab W31, Spine Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA. EM Kayanjm@ccf.org NR 25 TC 12 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 1 PY 2006 VL 31 IS 21 BP E790 EP E797 DI 10.1097/01.brs.0000238690.09903.4c PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 092DO UT WOS:000241077400023 PM 17023840 ER PT J AU Van de Graaff, EV Dutta, M Das, P Shry, EA Frederick, PD Blaney, M Pasta, DJ Steinhubl, SR AF Van de Graaff, Eric Dutta, Monisha Das, Pranab Shry, Eric A. Frederick, Paul D. Blaney, Martha Pasta, David J. Steinhubl, Steven R. TI Early coronary Revascularization diminishes the risk of ischemic stroke with acute myocardial infarction SO STROKE LA English DT Article DE angioplasty; myocardial infarction; stroke; thrombolysis ID C-REACTIVE PROTEIN; THROMBOLYTIC THERAPY; ENDOTHELIAL-CELLS; UNSTABLE ANGINA; INFLAMMATION; METAANALYSIS; ARTERY; PLAQUES; SIZE AB Background and Purpose-Ischemic stroke is an uncommon but devastating complication of myocardial infarction (MI). It is possible that delay in the acute revascularization of these patients influences the risk of peri-MI ischemic stroke independent of size of infarction or residual ventricular function. The influence of the timing and type of revascularization on risk of ischemic stroke in the patient with MI has not previously been assessed. Methods-We used the National Registry of Myocardial Infarction 3 and 4 databases to identify 45 997 subjects who received thrombolytic therapy and 47 876 patients who were treated with primary percutaneous transluminal coronary angioplasty for MI. In-hospital ischemic stroke occurred in 248 (0.54%) and 150 (0.31%) patients in the two groups, respectively. Patients were stratified based on time from presentation to initial therapy. Results-A statistically significant linear relationship between time to revascularization therapy and risk of in-hospital ischemic stroke was seen on univariate analysis. A multivariate model incorporating 26 other variables showed thrombolytic therapy within 15 minutes was associated with a lower risk of ischemic stroke (odds ratio, 0.58; 95% CI, 0.36-0.94). Primary angioplasty within 90 minutes of arrival was associated with a nonsignificant trend toward lower stroke risk (odds ratio, 0.68; 95% CI, 0.41-1.12). Interestingly, his benefit of early reperfusion therapy did not appear to be related to improvements in left ventricular function. Conclusion-Risk of in-hospital ischemic stroke with MI is closely tied to the time to revascularization with both thrombolytic and percutaneous transluminal coronary angioplasty therapies. Early revascularization is independently predictive of a lower risk of ischemic stroke, but the mechanism of this does not appear to be related to improved cardiac function. The records of 45 997 subjects who received thrombolytic therapy and 47 876 patients who were treated with primary percutaneous transluminal coronary angioplasty for myocardial infarction were analyzed to determine the relationship between time to revascularization and the occurrence of ischemic stroke. A statistically significant linear relationship between time to revascularization therapy and risk of in-hospital ischemic stroke was seen on univariate analysis. A multivariate model incorporating 26 other variables showed thrombolytic therapy within 15 minutes of presentation was associated with a lower risk of ischemic stroke, and angioplasty within 90 minutes was similarly associated with a nonsignificant trend toward lower stroke risk. C1 Nebraska Heart Inst, Omaha, NE USA. Brooke Army Med Ctr, San Antonio, TX USA. Genetech Inc, San Francisco, CA USA. RP Steinhubl, SR (reprint author), 900 S Limestone St,326 CT Wethington Bldg, Lexington, KY 40536 USA. EM steinhubl@uky.edu OI Pasta, David/0000-0003-2637-9293; Frederick, Paul/0000-0002-7936-5488 NR 27 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD OCT PY 2006 VL 37 IS 10 BP 2546 EP 2551 DI 10.1161/01.STR.0000240495.99425.0f PG 6 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 090GL UT WOS:000240938700026 PM 16960095 ER PT J AU Kelty, R AF Kelty, Ryan TI War and peace in an age of terrorism: A reader. SO TEACHING SOCIOLOGY LA English DT Book Review C1 US Mil Acad, West Point, NY USA. RP Kelty, R (reprint author), US Mil Acad, West Point, NY USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1307 NEW YORK AVE NW #700, WASHINGTON, DC 20005-4712 USA SN 0092-055X J9 TEACH SOCIOL JI Teach. Sociol. PD OCT PY 2006 VL 34 IS 4 BP 416 EP 417 PG 2 WC Education & Educational Research; Sociology SC Education & Educational Research; Sociology GA 097WS UT WOS:000241480800011 ER PT J AU Myint, KSA Endy, TP Shrestha, MP Shrestha, SK Vaughn, DW Innis, BL Gibbons, RV Kuschner, RA Seriwatana, J Scott, RM AF Myint, Khin Saw Aye Endy, Timothy P. Shrestha, Mrigendra P. Shrestha, Sanjaya K. Vaughn, David W. Innis, Bruce L. Gibbons, Robert V. Kuschner, Robert A. Seriwatana, Jitvimol Scott, Robert McN. TI Hepatitis E antibody kinetics in Nepalese patients SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE hepatitis E; HEV; enzyme; immunoassay; kinetics; Nepal ID NON-B-HEPATITIS; LINKED-IMMUNOSORBENT-ASSAY; TRANSMITTED NON-A; E VIRUS HEV; SYNTHETIC PEPTIDES; ENZYME-IMMUNOASSAY; DISEASE; IDENTIFICATION; IMMUNOGLOBULIN; EPIDEMIC AB A cohort of 62 Nepalese adults with acute hepatitis E was identified and total Ig as well as IgM levels to hepatitis E virus (HEV) capsid protein were determined using the Walter Reed Army Institute of Research (WRAIR) immunoassay. An antibody profile was constructed from serial serum specimens collected up to 14 months following the onset of illness. The decline in total Ig was rapid for the first 3 months. There followed a slow, sustained decline, but antibodies remained above the seropositive level of 20 WRAIR units. The decline of IgM was steeper than total Ig for the first 3 months, but IgM remained detectable after 14 months in 25% of cases. Study data contribute to an understanding of the pathophysiology of human hepatitis E and set an antibody response pattern to be targeted as a part of HEV vaccine development. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Walter Reed AFRIMS Res Unit, Kathmandu, Nepal. Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA. RP Myint, KSA (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-16 Rajvithi Rd, Bangkok 10400, Thailand. EM myintk@afrims.org NR 28 TC 32 Z9 33 U1 0 U2 2 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON W1N 1EY, ENGLAND SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD OCT PY 2006 VL 100 IS 10 BP 938 EP 941 DI 10.1016/j.trstmh.2005.12.005 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 079LN UT WOS:000240177900005 PM 16542692 ER PT J AU Morey, AF AF Morey, Allen F. TI Combined buccal mucosa graft and genital skin flap for reconstruction of extensive anterior urethral strictures - Editorial comment SO UROLOGY LA English DT Editorial Material C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD OCT PY 2006 VL 68 IS 4 BP 710 EP 710 DI 10.1016/j.urology..2006.07.012 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 101DS UT WOS:000241719700005 ER PT J AU Skahill, BE Doherty, J AF Skahill, Brian E. Doherty, John TI Efficient accommodation of local minima in watershed model calibration SO JOURNAL OF HYDROLOGY LA English DT Article DE calibration; local minima; parameter estimation; objective function; watershed modeling ID RAINFALL-RUNOFF MODELS; SHUFFLED COMPLEX EVOLUTION; AUTOMATIC CALIBRATION; OPTIMIZATION; SENSITIVITY; UNCERTAINTY; INFERENCE AB The Gauss-Marquardt-Levenberg (GML) method of computer-based parameter estimation, in common with other gradient-based approaches, suffers from the drawback that it may become trapped in local objective function minima, and thus report "optimized" parameter values that are not, in fact, optimized at all. This can seriously degrade its utility in the calibration of watershed models where local optima abound. Nevertheless, the method also has advantages, chief among these being its model-run efficiency, and its ability to report useful information on parameter sensitivities and covariances as a by-product of its use. It is also easily adapted to maintain this efficiency in the face of potential numerical problems (that adversely affect all parameter estimation methodologies) caused by parameter insensitivity and/or parameter correlation. The present paper presents two algorithmic enhancements to the GML method that retain its strengths, but which overcome its weaknesses in the face of local optima. Using the first of these methods an "intelligent search" for better parameter sets is conducted in parameter subspaces of decreasing dimensionality when progress of the parameter estimation process is slowed either by numerical instability incurred through problem ill-posedness, or when a local objective function minimum is encountered. The second methodology minimizes the chance of successive GML parameter estimation runs finding the same objective function minimum by starting successive runs at points that are maximally removed from previous parameter trajectories. As well as enhancing the ability of a GML-based method to find the global objective function minimum, the latter technique can also be used to find the locations of many non-global optima (should they exist) in parameter space. This can provide a useful means of inquiring into the well-posedness of a parameter estimation problem, and for detecting the presence of bimodal parameter and predictive probability distributions. The new methodologies are demonstrated by calibrating a Hydrological Simulation Program-FORTRAN (HSPF) model against a time series of daily flows. Comparison with the SCE-UA method in this calibration context demonstrates a high level of comparative model run efficiency for the new method. (c) 2006 Elsevier B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Hydrol Syst Branch,Waterways Expt Stn, Vicksburg, MS 39180 USA. Univ Queensland, Dept Civil Engn, St Lucia, Qld 4068, Australia. Watermark Numer Comp, Brisbane, Qld, Australia. RP Skahill, BE (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Hydrol Syst Branch,Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM brian.e.skahill@erdc.usace.army.mil NR 29 TC 45 Z9 46 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD SEP 30 PY 2006 VL 329 IS 1-2 BP 122 EP 139 DI 10.1016/j.jhydrol.2006.02.005 PG 18 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 089NV UT WOS:000240888300010 ER PT J AU Wang, DH Hevey, M Juompan, LY Trubey, CM Raja, NU Deitz, SB Woraratanadharm, J Luo, M Yu, H Swain, BM Moore, KM Dong, JY AF Wang, Danher Hevey, Michael Juompan, Laure Y. Trubey, Charles M. Raja, Nicholas U. Deitz, Stephen B. Woraratanadharm, Jan Luo, Min Yu, Hong Swain, Benjamin M. Moore, Kevin M. Dong, John Y. TI Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges SO VIROLOGY LA English DT Article DE Marburg virus; vaccine; cAdVax; glycoprotein; challenge; Musoke; Ravn; Ci67 ID EBOLA-VIRUS; NONHUMAN-PRIMATES; PARTICLES PROTECT; IMMUNE-RESPONSES; GLYCOPROTEIN; INFECTION; GENES AB The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs kvaccinated with at least 5 X 10(7) pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV. (c) 2006 Elsevier Inc. All rights reserved. C1 GenPhar Inc, Div Biodef Vaccines, Mt Pleasant, SC 29464 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29403 USA. RP Dong, JY (reprint author), GenPhar Inc, Div Biodef Vaccines, 871 Lowcountry Blvd, Mt Pleasant, SC 29464 USA. EM dongj@genphar.com NR 27 TC 30 Z9 32 U1 1 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 30 PY 2006 VL 353 IS 2 BP 324 EP 332 DI 10.1016/j.virol.2006.05.033 PG 9 WC Virology SC Virology GA 090DN UT WOS:000240930900008 PM 16820184 ER PT J AU Pineda, AC Karna, SP AF Pineda, Andrew C. Karna, Shashi P. TI (Hyper)polarizabilities of isolated GaN nanoclusters SO CHEMICAL PHYSICS LETTERS LA English DT Article ID GALLIUM-ARSENIDE CLUSTERS; NONLINEAR OPTICAL SUSCEPTIBILITIES; SMALL GAAS CLUSTERS; ELECTRONIC-STRUCTURE; SEMICONDUCTOR CLUSTERS; VIBRATIONAL PROPERTIES; POLARIZABILITIES; ABSORPTION; SPECTRA AB The linear and nonlinear polarizabili ties of hydrogen-terminated Ga-m NnHx (m = n = 1, 4, 7, 17) clusters have been calculated by the ab initio time-dependent Hartree-Fock method. The calculated linear polarizability per Ga-N unit for the Ga17N17H38 cluster shows excellent agreement with the corresponding value estimated from the measured dielectric constant of bulk GaN. The calculated (hyper)polarizabilities show a strong dependence upon the size and the geometry of the cluster. For clusters containing equal numbers of Ga and N atoms but differing in geometry, the structure with a reduced symmetry has a much larger first-order NLO coefficient than that with a higher symmetry. Published by Elsevier B.V.. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. USAF, Res Lab, Space Vehicles Directorate, Kirtland AFB, NM 87117 USA. Univ New Mexico, Ctr High Performance Comp, Albuquerque, NM 87131 USA. Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA. RP Karna, SP (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM andrew.pineda@kirtland.af.mil; karna@us.army.mil RI Schaff, William/B-5839-2009 NR 27 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 29 PY 2006 VL 429 IS 1-3 BP 169 EP 173 DI 10.1016/j.cplett.2006.07.067 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 091HV UT WOS:000241018800032 ER PT J AU Watson, NE VanWingerden, MM Pierce, KM Wright, BW Synovec, RE AF Watson, Nathanial E. VanWingerden, Matthew M. Pierce, Karisa M. Wright, Bob W. Synovec, Robert E. TI Classification of high-speed gas chromatography-mass spectrometry data by principal component analysis coupled with piecewise alignment and feature selection SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE alignment; gas chromatography; feature selection; principal component analysis; fuel; chemometrics; GC-MS ID AUTOMOTIVE GASOLINE SAMPLES; CAPILLARY-ELECTROPHORESIS; ALGORITHM; OIL AB A useful methodology is introduced for the analysis of data obtained via gas chromatography with mass spectrometry (GC-MS) utilizing a complete mass spectrum at each retention time interval in which a mass spectrum was collected. Principal component analysis (PCA) with preprocessing by both piecewise retention time alignment and analysis of variance (ANOVA) feature selection is applied to all mass channels collected. The methodology involves concatenating all concurrently measured individual m/z chromatograms from m/z 20 to 120 for each GC-MS separation into a row vector. All of the sample row vectors are incorporated into a matrix where each row is a sample vector. This matrix is piecewise aligned and reduced by ANOVA feature selection. Application of the preprocessing steps (retention time alignment and feature selection) to all mass channels collected during the chromatographic separation allows considerably more selective chemical information to be incorporated in the PCA classification, and is the primary novelty of the report. This methodology is objective and requires no knowledge of the specific analytes of interest, as in selective ion monitoring (SIM), and does not restrict the mass spectral data used, as in both SIM and total ion current (TIC) methods. Significantly, the methodology allows for the classification of data with low resolution in the chromatographic dimension because of the added selectivity from the complete mass spectral dimension. This allows for the successful classification of data over significantly decreased chromatographic separation times, since high-speed separations can be employed. The methodology is demonstrated through the analysis of a set of four differing gasoline samples that serve as model complex samples. For comparison, the gasoline samples are analyzed by GC-MS over both 10-min and 10-s separation times. The successfully classified 10-min GC-MS TIC data served as the benchmark analysis to compare to the 10-s data. When only alignment and feature selection was applied to the 10-s gasoline separations using GC-MS TIC data, PCA failed. PCA was successful for 10-s gasoline separations when the methodology was applied with all the m/z information. With ANOVA feature selection, chromatographic regions with Fisher ratios greater than 1500 were retained in a new matrix and subjected to PCA yielding successful classification for the 10-s separations. (c) 2006 Elsevier B.V. All rights reserved. C1 Univ Washington, Dept Chem, Seattle, WA 98195 USA. Pacific NW Natl Lab, Richland, WA 99352 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Synovec, RE (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM synovec@chem.washington.edu NR 21 TC 25 Z9 26 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD SEP 29 PY 2006 VL 1129 IS 1 BP 111 EP 118 DI 10.1016/j.chroma.2006.06.087 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 088BX UT WOS:000240787600017 PM 16860329 ER PT J AU Walker, AL Walker, CW AF Walker, Alyssa L. Walker, Charles W., Jr. TI Biological fuel cell and an application as a reserve power source SO JOURNAL OF POWER SOURCES LA English DT Article DE biological fuel cell; Saccharomyces cerevisiae; yeast; power; reserve cell ID ETHANOL/OXYGEN BIOFUEL CELL; MEDIATOR-LESS; ELECTRICITY-GENERATION; GLUCOSE; OPERATION AB A biological fuel cell was constructed in which the metabolism of glucose by yeast provided the electrons. A two compartment plexiglass fuel cell was constructed with platinum electrodes separated by a proton conducting membrane. One half of the cell contained yeast, Saccharomyces cerevisiae, glucose, and an electron mediator, methylene blue. The other half contained an electron acceptor, potassium ferricyanide. Electrons produced during the metabolism of glucose by the yeast were captured by the methylene blue and transferred to the platinum electrode, traveled through the external circuit to the cathode compartment, and were finally accepted by the potassium ferricyanide. When yeast was added to the fuel cell the open circuit potential was similar to 0.5 V. Electrical current was measured while holding the cell voltage at 0.3 and 0.1 V. Current output was optimized for the initial concentration of yeast, temperature, glucose concentration, agitation and oxygen content. The optimum conditions for producing current within the scope of this study were obtained with agitated, partially oxygenated electrolyte at 45 degrees C containing 0.1 M glucose. (c) 2006 Elsevier B.V. All rights reserved. C1 USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Walker, CW (reprint author), USA, Res Lab, Electrochem Branch, 2800 Powder Mill Rd,AMRSD-ARL,SE-DC, Adelphi, MD 20783 USA. EM cwalker@arl.army.mil NR 24 TC 41 Z9 42 U1 6 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 29 PY 2006 VL 160 IS 1 BP 123 EP 129 DI 10.1016/j.jpowsour.2006.01.077 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 091ZQ UT WOS:000241067200016 ER PT J AU Roychoudhury, S Lyubovsky, M Walsh, D Chu, D Kallio, E AF Roychoudhury, Subir Lyubovsky, Maxim Walsh, D. Chu, Deryn Kallio, Erik TI Design and development of a diesel and JP-8 logistic fuel processor SO JOURNAL OF POWER SOURCES LA English DT Article DE JP-8; diesel; ATR; desulfurization; microlith(R); reformer ID OXIDATION; METHANE AB The paper describes the design and performance of a breadboard prototype for a 5 kW fuel-processor for powering a solid oxide fuel cell (SOFC) stack. The system was based on a small, modular catalytic Microlith auto-thermal (ATR) reactor with the versatility of operating on diesel, Jet-A or JP-8 fuels. The reforming reactor utilized Microlith substrates and catalyst technology (patented and trademarked). These reactors have demonstrated the capability of efficiently reforming liquid and gaseous hydrocarbon fuels at exceptionally high power densities. The performance characteristics of the auto-thermal reactor (ATR) have been presented along with durability data. The fuel processor integrates fuel preparation, steam generation, sulfur removal, pumps, blowers and controls. The system design was developed via ASPEN (R) Engineering Suite process simulation software and was analyzed with reference to system balance requirements. Since the fuel processor has not been integrated with a fuel cell, aspects of thermal integration with the stack have not been specifically addressed. (c) 2006 Elsevier B.V. All rights reserved. C1 Precis Combust Inc, N Haven, CT 06473 USA. USA, Res Lab, SEDC, Adelphi, MD 20783 USA. USA, TARDEC, Warren, MI 48397 USA. RP Roychoudhury, S (reprint author), Precis Combust Inc, 410 Sackett Point Rd, N Haven, CT 06473 USA. EM sroychoudhury@precision-combustion.com NR 4 TC 40 Z9 40 U1 2 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 29 PY 2006 VL 160 IS 1 BP 510 EP 513 DI 10.1016/j.jpowsour.2005.12.101 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 091ZQ UT WOS:000241067200066 ER PT J AU Cole, CA Urban, CA Russo, P Murray, J Hoyt, D Brooks, RP AF Cole, Charles Andrew Urban, Christopher A. Russo, Paul Murray, Jason Hoyt, Dave Brooks, Robert P. TI Comparison of the long-term water levels of created and natural reference wetlands in northern New York, USA SO ECOLOGICAL ENGINEERING LA English DT Article DE creation; hydrology; mitigation; New York; reference; wetlands ID RESTORATION AB Long-term evaluation of hydrology on created wetlands in the United States is rare, as most such assessments are short-term and driven by regulatory and permit requirements. Longterm studies are critical to the understanding of the development of function in created wetlands. We measured water levels at 12-h intervals at five created wetlands at Fort Drum, northern New York, from 1994 to 2003 and compared that data with information from three reference wetlands, collected at the beginning and the end of that 10-year period. During that time span, the created wetlands were wetter than the reference wetlands as measured by median depth to water and the percentage of time water was within 30 cm of the surface. The two groups also differed in the duration of dry, saturated, and inundated periods. The mitigation wetlands were wetter than the reference wetlands likely as a result of the practice of excavating down to water table depths to generate site hydrology. (c) 2006 Elsevier B.V. All rights reserved. C1 Penn Fish & Boat Commiss, Bellefonte, PA 16823 USA. USA, Publ Works Environm Div, Ft Drum, NY 13602 USA. Vermont State Off, Assistant State Conservationist Programs, Colchester, VT 05446 USA. Penn State Univ, Cooperat Wetlands Ctr, Dept Geog, University Pk, PA 16802 USA. Penn State Univ, Dept Landscape Architecture, Ctr Watershed Stewardship, State Coll, PA 16801 USA. RP Cole, CA (reprint author), Penn State Univ, Dept Landscape Architecture, Ctr Watershed Stewardship, 227 E Calder Way, State Coll, PA 16801 USA. EM cac13@psu.edu NR 18 TC 8 Z9 8 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD SEP 28 PY 2006 VL 27 IS 2 BP 166 EP 172 DI 10.1016/j.ecoleng.2006.03.003 PG 7 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 089BQ UT WOS:000240855300011 ER PT J AU Voshell, SM Lee, SJ Gagne, MR AF Voshell, Sharon M. Lee, Stephen J. Gagne, Michel R. TI The discovery of an enantioselective receptor for (-)-adenosine from a racemic dynamic combinatorial library SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID DIASTEREOSELECTIVE AMPLIFICATION; POLARIMETRIC DETECTION; CHIRAL ANALYSIS; RECOGNITION; DERIVATIVES; COMPLEXATION; CHEMISTRY; METAL; ION C1 USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. RP Lee, SJ (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM stephen.lee2@us.army.mil; mgagne@unc.edu NR 20 TC 44 Z9 45 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD SEP 27 PY 2006 VL 128 IS 38 BP 12422 EP 12423 DI 10.1021/ja0647699 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA 085OF UT WOS:000240612700036 PM 16984185 ER PT J AU Hite, J Thaler, T Khanna, R Abernathy, CR Pearton, SJ Park, JH Steckl, AJ Zavada, JM AF Hite, J. Thaler, T. Khanna, R. Abernathy, C. R. Pearton, S. J. Park, J. H. Steckl, A. J. Zavada, J. M. TI Optical and magnetic properties of Eu-doped GaN SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; RED-LIGHT EMISSION; VISIBLE CATHODOLUMINESCENCE; ELECTROLUMINESCENT DEVICES; IMPLANTED GAN; ER; GROWTH; PHOTOLUMINESCENCE; ALN; LUMINESCENCE AB GaN films were doped with Eu to a concentration of similar to 0.12 at. % during growth at 800 degrees C by molecular beam epitaxy, with the Eu cell temperature held constant at 470 S C. All samples were postannealed at 675 degrees C. The films exhibited strong photoluminescence (PL) in the red (622 nm) whose absolute intensity was a function of the Ga flux during growth, which ranged from 3.0 x 10(-7) to 5.4 x 10(-7) Torr. The maximum PL intensity was obtained at a Ga flux of 3.6 x 10(-7) Torr. The samples showed room temperature ferromagnetism with saturation magnetization of similar to 0.1-0.45 emu/cm(3), consistent with past reports where the Eu was found to be predominantly occupying substitutional Ga sites. There was an inverse correlation between the PL intensity and the saturation magnetization in the films. X-ray diffraction showed the presence of EuGa phases under all the growth conditions but these cannot account for the observed magnetic properties. (c) 2006 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA. RP Hite, J (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Hite, Jennifer/L-5637-2015; OI Hite, Jennifer/0000-0002-4090-0826; Steckl, Andrew/0000-0002-1868-4442 NR 37 TC 35 Z9 35 U1 0 U2 19 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 25 PY 2006 VL 89 IS 13 AR 132119 DI 10.1063/1.2358293 PG 3 WC Physics, Applied SC Physics GA 089JE UT WOS:000240875800076 ER PT J AU Hulten, E Jackson, JL Douglas, K George, S Villines, TC AF Hulten, Eddie Jackson, Jeffrey L. Douglas, Kevin George, Susan Villines, Todd C. TI The effect of early, intensive statin therapy on acute coronary syndrome - A meta-analysis of randomized controlled trials SO ARCHIVES OF INTERNAL MEDICINE LA English DT Review ID ACUTE MYOCARDIAL-INFARCTION; COA REDUCTASE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DETECT PUBLICATION BIAS; LOW-DENSITY-LIPOPROTEIN; ATORVASTATIN 80 MG; ARTERY-DISEASE; CLINICAL-OUTCOMES; LDL-CHOLESTEROL; BLOOD-PRESSURE AB Background: In addition to well-established secondary prevention benefits for atherosclerotic coronary artery disease, 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) reductase inhibitors (statins) are hypothesized to have short-term benefit in acute coronary syndrome (ACS), yet the data are inconsistent, with some trials underpowered to demonstrate therapeutic benefit. Our objective was to determine the effects of early, intensive statin therapy for ACS. Data Sources: Studies found in the PubMed, MEDLINE, EMBASE, BIOSIS, SciSearch, PASCAL, and International Pharmaceutical Abstracts (IPA) databases and the Cochrane Controlled Trials Register published between January 1974 and May 2006. Study Selection: Randomized controlled trials of statins begun within 14 days of hospitalization for ACS were included. Data Extraction: Two investigators independently abstracted study quality, characteristics, and outcomes. Data Synthesis: Thirteen randomized controlled trials published before May 2006 were available, involving 17 963 adults (median number of patients, 135; median follow-up, 6 months). Early, intensive statin therapy for ACS decreased the rate of death and cardiovascular events over 2 years of follow-up (hazard ratio, 0.81 [95% confidence interval, 0.77-0.87]) (Q(3)=58.54; P < 001; I-2= 95%). Survival curves revealed that this benefit begins to occur between 4 and 12 months, achieving statistical significance by 12 months. There was no evidence of publication bias, and sensitivity analyses did not identify a dominating study or study characteristic. Conclusions: Early, intensive statin therapy reduces death and cardiovascular events after 4 months of treatment. The validity of this finding would be strengthened by an analysis of individual patient data. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Gen Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Bethesda, MD USA. RP Hulten, E (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM edward.hulten@us.army.mil OI Hulten, Edward/0000-0001-9281-0032 NR 43 TC 111 Z9 123 U1 0 U2 8 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD SEP 25 PY 2006 VL 166 IS 17 BP 1814 EP 1821 DI 10.1001/archinte.166.17.1814 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 087GI UT WOS:000240730500004 PM 17000936 ER PT J AU Renehan, J AF Renehan, John TI The thin red line SO NEW REPUBLIC LA English DT Letter C1 USA, Infantry Div 3, Ft Stewart, GA USA. RP Renehan, J (reprint author), USA, Infantry Div 3, Ft Stewart, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW REPUBLIC INC PI WASHINGTON PA 1331 H STREET, NW STE 700, WASHINGTON, DC 20005 USA SN 0028-6583 J9 NEW REPUBLIC JI New Repub. PD SEP 25 PY 2006 VL 235 IS 13 BP 5 EP 5 PG 1 WC Political Science SC Government & Law GA 087AZ UT WOS:000240715900004 ER PT J AU Allen, JL Jow, TR Wolfenstine, J AF Allen, J. L. Jow, T. R. Wolfenstine, J. TI Low temperature performance of nanophase Li4Ti5O12 SO JOURNAL OF POWER SOURCES LA English DT Article DE Li4Ti5O12; anode; Li-ion battery; low temperature; nanophase ID NANOCRYSTALLINE LI4TI5O12; ION BATTERIES; LITHIUM; INSERTION; CELLS AB The low temperature electrochemical performances of 700 and 350 nm Li4Ti5O12 were compared. At high rate, room temperature and at low rate and low temperature (0, -10, -20 and -30 degrees C), the 350nm Li4Ti5O12 showed higher capacity than the 700nm Li4Ti5O12. This difference is proposed to result from the shorter diffusion lengths and higher number of lithium insertion sites in the 350 nm Li4Ti5O12 compared to the 700 nm Li4Ti5O12. However, at high rate and low temperature, a transition in performance was observed, that is, the 700 nm. material had higher capacity. At high rate and low temperature, it is proposed that interparticle contact resistance becomes rate limiting owing to the temperature dependence of this property and this accounts for the different behavior at low temperature and high rate. Published by Elsevier B.V. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Allen, JL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jallen@arl.army.mil NR 21 TC 65 Z9 75 U1 9 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 22 PY 2006 VL 159 IS 2 BP 1340 EP 1345 DI 10.1016/j.jpowsour.2005.12.039 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 090OB UT WOS:000240959500069 ER PT J AU Tsen, KT Dykeman, EC Sankey, OF Lin, NT Tsen, SWD Kiang, JG AF Tsen, K. T. Dykeman, Eric C. Sankey, Otto F. Lin, Nien-Tsung Tsen, Shaw-Wei D. Kiang, Juliann G. TI Observation of the low frequency vibrational modes of bacteriophage M13 in water by Raman spectroscopy SO VIROLOGY JOURNAL LA English DT Article ID TOBACCO-MOSAIC-VIRUS; GE QUANTUM DOTS; NANOWIRES AB Background: Recently, a technique which departs radically from conventional approaches has been proposed. This novel technique utilizes biological objects such as viruses as nano-templates for the fabrication of nanostructure elements. For example, rod-shaped viruses such as the M13 phage and tobacco mosaic virus have been successfully used as biological templates for the synthesis of semiconductor and metallic nanowires. Results and discussion: Low wave number (<= 20 cm(-1)) acoustic vibrations of the M13 phage have been studied using Raman spectroscopy. The experimental results are compared with theoretical calculations based on an elastic continuum model and appropriate Raman selection rules derived from a bond polarizability model. The observed Raman mode has been shown to belong to one of the Raman-active axial torsion modes of the M13 phage protein coat. Conclusion: It is expected that the detection and characterization of this low frequency vibrational mode can be used for applications in nanotechnology such as for monitoring the process of virus functionalization and self-assembly. For example, the differences in Raman spectra can be used to monitor the coating of virus with some other materials and nano-assembly process, such as attaching a carbon nanotube or quantum dots. C1 Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. Tzu Chi Univ, Inst Microbiol Immunol & Mol Med, Hualien 970, Taiwan. Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. RP Tsen, KT (reprint author), Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. EM tsen@asu.edu; eric.dykeman@asu.edu; otto.sankey@asu.edu; ntlin@mail.tcu.edu.tw; swdtsen@yahoo.com; Juliann.Kiang@na.amedd.army.mil NR 22 TC 9 Z9 9 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD SEP 22 PY 2006 VL 3 AR 79 DI 10.1186/1743-422X-3-79 PG 11 WC Virology SC Virology GA 182MJ UT WOS:000247508400001 PM 16995944 ER PT J AU Taguenang, JM Kassu, A Govindarajalu, G Dokhanian, M Sharma, A Ruffin, PB Brantley, C AF Taguenang, J. M. Kassu, A. Govindarajalu, G. Dokhanian, M. Sharma, A. Ruffin, P. B. Brantley, C. TI Fabrication and characterization of a diffraction-grating transducer in thin polybutadiene rubber film for sensing dynamical strain SO APPLIED OPTICS LA English DT Article ID FIBER-BRAGG GRATINGS; DISPLACEMENT MEASUREMENT SYSTEM; DIGITAL PHASE DEMODULATION; SURFACE-RELIEF GRATINGS; LESS-THAN; SENSOR; GAUGE; LONG AB Surface relief gratings are holographically fabricated in thin polybutadiene rubber films produced by both spin coating and dip coating on glass and metal substrates. These thin-film gratings are characterized for their application as efficient transducers for detecting dynamic strain in solids. The performance of these rubber-grating transducers is compared to surface-mounted fiber Bragg gratings for a range of frequencies between 50 Hz and 30 kHz. Dynamic-strain sensitivity around 1 n epsilon/root Hz is recorded for thin rubber-film grating transducers. (c) 2006 Optical Society of America. C1 Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. USA, RDECOM, AMSRD, AMR SG, Redstone Arsenal, AL 35898 USA. RP Taguenang, JM (reprint author), Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. EM anup.sharma@email.aamu.edu NR 32 TC 2 Z9 2 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 20 PY 2006 VL 45 IS 27 BP 6903 EP 6909 DI 10.1364/AO.45.006903 PG 7 WC Optics SC Optics GA 089MX UT WOS:000240885800002 PM 16946763 ER PT J AU He, HY Pandey, R Karna, SP AF He, Haiying Pandey, Ravindra Karna, Shashi P. TI Theoretical study of molecule mediated spin-polarized electron tunneling between magnetic materials SO CHEMICAL PHYSICS LETTERS LA English DT Article ID SPINTRONICS; CONDUCTANCE; MICROSCOPE AB Spin-polarized electron tunneling between a Ni tip and a self-assembled monolayer, consisting of sigma-bonded bicyclo[2.2.2]octane-1,4-dithiol molecules, deposited on Ni(111) surface is calculated by density functional approach within Bardeen, Tersoff, and Hamann formalism. The magnitude of the tunneling current is predicted to depend on the spin alignments of the probe tip and the substrate. Comparison with a similar study involving benzene-dithiol, a pi-conjugated molecule, suggests that the magnitude of the tunnel current as well as the spin-dependent current is strongly influenced by the nature of the chemical bonds in the molecular structure. (c) 2006 Elsevier B.V. All rights reserved. C1 Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. Michigan Technol Univ, MultiScale Technol Inst, Houghton, MI 49931 USA. USA, Res Lab, Weapons & Mat Res Directorate, AMSRD,ARL,WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, 1400 Townsend Dr, Houghton, MI 49931 USA. EM pandey@mtu.edu; skarna@arl.army.mil RI Pandey, Ravi/A-8759-2009 NR 20 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 20 PY 2006 VL 428 IS 4-6 BP 411 EP 415 DI 10.1016/j.cplett.2006.07.066 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 087SS UT WOS:000240763200036 ER PT J AU Klote, MM Engler, RJM Martin, BL Cummings, JF Wortmann, GW Ludwig, GV AF Klote, Mary M. Engler, Renata J. M. Martin, Bryan L. Cummings, James F. Wortmann, Glenn W. Ludwig, George V. TI Vaccinia DNA in blood after smallpox vaccination SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID VIRUS C1 Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Immunol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. USA, Med Res & Mat Command, Washington, DC 20310 USA. RP Klote, MM (reprint author), Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. EM mary.klote@us.army.mil NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD SEP 20 PY 2006 VL 296 IS 11 BP 1350 EP 1351 DI 10.1001/jama.296.11.1350-c PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 085HS UT WOS:000240595800016 PM 16985223 ER PT J AU Gose, WA Hanson, RE Dalziel, IWD Pancake, JA Seidel, EK AF Gose, Wulf A. Hanson, Richard E. Dalziel, Ian W. D. Pancake, James A. Seidel, Emily K. TI Paleomagnetism of the 1.1 Ga Umkondo large igneous province in southern Africa SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article ID DRONNING MAUD LAND; NORTHERN CAPE PROVINCE; LIMPOPO MOBILE BELT; NAMAQUA-NATAL BELT; MIDCONTINENT RIFT; EASTERN ZIMBABWE; KAAPVAAL CRATON; TECTONIC IMPLICATIONS; KEWEENAWAN ROCKS; BUSHVELD COMPLEX AB [ 1] The Umkondo dolerites are present over a wide area in the Kalahari craton, southern Africa. Thirty-nine sampling sites in Botswana and South Africa yielded tightly grouped paleomagnetic directions due south with shallow inclinations and three sites of opposite polarity. The dolerites have U-Pb single-crystal baddeleyite or zircon crystallization ages of 1112 +/- 0.5 to 1108 +/- 0.9 Ma. These results can be combined with published data from 39 additional Umkondo sites and 33 sites in the Grunehogna Province of Antarctica after restoring East Antarctica to its position next to southern Africa. Grouping the sites geographically yields 10 site mean poles with mean at 64.0 degrees N, 38.8 degrees E, A(95) = 3.7 degrees. This Umkondo pole can be correlated with Keweenawan poles from Laurentia. Because both sets of poles are precisely of the same age as well as predominantly of one polarity, the relative orientation of the two cratons within the Rodinia supercontinent is fixed. This implies that the Namaqua-Natal-Maud belt which rims the southern part of the Kalahari craton, faced away from Laurentia. The Umkondo pole combined with published poles suggest that the Kalahari craton remained distinctly south of the Laurentian craton between 1.1 and 1.0 Ga, making it highly unlikely that the two cratons collided. C1 Univ Texas, Dept Geol Sci, Austin, TX 78712 USA. Texas Christian Univ, Dept Geol, Ft Worth, TX 76129 USA. Univ Texas, Inst Geophys, Austin, TX 78759 USA. EG&G Tech Serv Inc, Morgantown, WV 26505 USA. USA, Corps Engineers, Ft Worth, TX 76102 USA. RP Gose, WA (reprint author), Univ Texas, Dept Geol Sci, Austin, TX 78712 USA. EM wulf@mail.utexas.edu RI Dalziel, Ian/G-5926-2010 NR 87 TC 30 Z9 30 U1 0 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD SEP 20 PY 2006 VL 111 IS B9 AR B09101 DI 10.1029/2005JB003897 PG 18 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 088RN UT WOS:000240828900001 ER PT J AU Adams, B Holmes, EC Zhang, C Mammen, MP Nimmannitya, S Kalayanarooj, S Boots, M AF Adams, B. Holmes, E. C. Zhang, C. Mammen, M. P., Jr. Nimmannitya, S. Kalayanarooj, S. Boots, M. TI Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE cross-immunity; mathematical model; phylogenetics; rsv; phase pattern ID ANTIBODY-DEPENDENT ENHANCEMENT; TRANSMISSION DYNAMICS; HEMORRHAGIC-FEVER; THAILAND; PREVALENCE; EVOLUTION; SELECTION; DISEASE; MODEL; PATHOGENS AB Dengue virus, the causative agent of dengue fever and its more serious manifestation dengue hemorrhagic fever, is widespread throughout tropical and subtropical regions. The virus exists as four distinct serotypes, all of which have cocirculated in Bangkok for several decades with epidemic outbreaks occurring every 8-10 years. We analyze time-series data of monthly infection incidence, revealing a distinctive pattern with epidemics of serotypes 1, 2, and 3 occurring at approximately the same time and an isolated epidemic of serotype 4 occurring in the intervening years. Phylogenetic analysis of virus samples collected over the same period shows that clade replacement events are linked to the epidemic cycle and indicates that there is an interserotypic immune reaction. Using an epidemic model with stochastic seasonal forcing showing 8- to 10-year epidemic oscillations, we demonstrate that moderate cross-protective immunity gives rise to persistent out-of-phase oscillations similar to those observed in the data, but that strong or weak cross-protection or cross-enhancement only produces in-phase patterns. This behavior suggests that the epidemic pattern observed in Bangkok is the result of cross-protective immunity and may be significantly altered by changes in the interserotypic immune reaction. C1 Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England. Kyushu Univ, Fac Sci, Dept Biol, Fukuoka 8128581, Japan. Penn State Univ, Mueller Lab, Dept Biol, Ctr Infect Dynam, University Pk, PA 16802 USA. NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. Armed Forces Res Inst Med Sci, USA Med Component, Dept Virol, Bangkok 10400, Thailand. Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. RP Adams, B (reprint author), Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England. EM ben@bio-math10.biology.kyushu-u.ac.jp RI U-ID, Kyushu/C-5291-2016; OI Adams, Ben/0000-0001-9955-5361; Holmes, Edward/0000-0001-9596-3552 FU Wellcome Trust NR 43 TC 123 Z9 125 U1 0 U2 27 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 19 PY 2006 VL 103 IS 38 BP 14234 EP 14239 DI 10.1073/pnas.0602768103 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 087MN UT WOS:000240746600059 PM 16966609 ER PT J AU Wang, HT Jang, S Anderson, T Chen, JJ Kang, BS Ren, F Voss, LF Stafford, L Khanna, R Gila, BP Pearton, SJ Shen, H LaRoche, JR Smith, KV AF Wang, Hung-Ta Jang, S. Anderson, T. Chen, J. J. Kang, B. S. Ren, F. Voss, L. F. Stafford, L. Khanna, R. Gila, B. P. Pearton, S. J. Shen, H. LaRoche, Jeffrey R. Smith, Kurt V. TI Increased Schottky barrier heights for Au on n- and p-type GaN using cryogenic metal deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRON-MOBILITY TRANSISTORS; MULTILAYER OHMIC CONTACTS; THERMAL-STABILITY; ALGAN/GAN HETEROSTRUCTURES; METALLIZATION; TEMPERATURES; TI/AL/MO/AU; RESISTANCE; WSIX; IMPLANTATION AB An enhancement of similar to 0.18 eV (an 18% increase) in Schottky barrier height was obtained for Au deposited at cryogenic temperatures on n-type GaN relative to conventional deposition at 300 K (barrier height of 1.0 eV). Enhancements of 0.04-0.11 eV were achieved for Au deposition on p-GaN under the same conditions. The increase in barrier height on n-GaN persists for annealing temperatures up to similar to 200 degrees C. At higher annealing temperatures, both types of diodes show a deterioration in rectifying behavior. The reverse current of low temperature deposited diodes was approximately two orders of magnitude lower than conventional Au/n-GaN diodes. The ideality factor of the cryogenically processed n-type devices (similar to 1.06) was similar to that for room temperature diodes (1.13). This simple process method has potential for improving output resistance and power gain and lowering gate leakage current and noise in GaN-based transistors. (c) 2006 American Institute of Physics. C1 Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. USA, Res Labs, Adelphi, MD 20783 USA. Raytheon RF Components, Andover, MA 01810 USA. RP Wang, HT (reprint author), Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Voss, Lars/C-3623-2009 NR 30 TC 6 Z9 7 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 18 PY 2006 VL 89 IS 12 AR 122106 DI 10.1063/1.2356698 PG 3 WC Physics, Applied SC Physics GA 086NM UT WOS:000240680300057 ER PT J AU Lake, JM Wong, RKH AF Lake, J. M. Wong, R. K. H. TI Review article: the management of achalasia - a comparison of different treatment modalities SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Review ID BOTULINUM TOXIN INJECTION; LAPAROSCOPIC HELLER MYOTOMY; TERM-FOLLOW-UP; RANDOMIZED CONTROLLED-TRIAL; LOWER ESOPHAGEAL SPHINCTER; PREVIOUS ENDOSCOPIC TREATMENT; PNEUMATIC BALLOON DILATION; MINIMALLY INVASIVE SURGERY; COST-MINIMIZATION ANALYSIS; INTRASPHINCTERIC INJECTION AB Background Achalasia is an uncommon primary oesophageal motor disorder with an unknown aetiology. Therapeutic options for achalasia are aimed at decreasing the lower oesophageal sphincter pressure, improving the oesophageal empting, and most importantly, relieving the symptoms of achalasia. Modalities for treatment include pharmacologic, endoscopic, pneumatic dilatation and surgical. The decision of which modality to use involves the consideration of multiple clinical and economic factors. Aim To review the management strategies currently available for achalasia. Methods A Medline search identified the original articles and reviews the published in the English language literature between 1966 and 2006. Results The results reveal that pharmacotherapy, injection of botulinum toxin, pneumatic dilatation and minimally invasive surgical oesophagomyotomy are variably effective at controlling the symptoms of achalasia but that each modality has specific strengths and weaknesses which make them each suitable in certain populations. Overall, pharmacologic therapy results in the shortest lived, least durable response followed by botulinum toxin injection, pneumatic dilatation and surgery, respectively. Conclusion The optimal treatment for achalasia remains an area of controversy given our lack of complete understanding about the pathophysiology of the disease as well as the high numbers of clinical relapse after treatment. Further research focusing on optimal dosing of botulinum toxin injection and optimal timing of repeated graduated pneumatic dilatations could add to our knowledge regarding long-term therapy. C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC USA. RP Wong, RKH (reprint author), 6900 Georgia Ave,NW,Bldg 2,7F43, Washington, DC 20307 USA. EM roy.wong@na.amedd.army.mil NR 93 TC 38 Z9 43 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0269-2813 J9 ALIMENT PHARM THERAP JI Aliment. Pharmacol. Ther. PD SEP 15 PY 2006 VL 24 IS 6 BP 909 EP 918 DI 10.1111/j.1365-2036.2006.03079.x PG 10 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 079VP UT WOS:000240206300002 PM 16948803 ER PT J AU Xia, Y Vonhilsheimer, GE AF Xia, Yang Vonhilsheimer, George E. TI Pruritic rash in the intertriginous areas SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Xia, Y (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2006 VL 74 IS 6 BP 1011 EP 1013 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 086AR UT WOS:000240646000011 PM 17002038 ER PT J AU Hepburn, MJ Purcell, BK Lawler, JV Coyne, SR Petitt, PL Sellers, KD Norwood, DA Ulrich, MP AF Hepburn, Matthew J. Purcell, Bret K. Lawler, James V. Coyne, Susan R. Petitt, Patricia L. Sellers, Karen D. Norwood, David A. Ulrich, Melanie P. TI Live vaccine strain Francisella tularensis is detectable at the inoculation site but not in blood after vaccination against Tularemia SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID POLYMERASE-CHAIN-REACTION; ULCEROGLANDULAR TULAREMIA; PCR; SPECIMENS; DIAGNOSIS; ASSAY AB Introduction. Live vaccine strain ( LVS) Francisella tularensis is a live, attenuated investigational tularemia vaccine that has been used by the US Army for decades to protect laboratory workers. Postvaccination bacterial kinetic characteristics of LVS at the inoculation site and in the blood are unknown and, therefore, were assessed in a prospective study. LVS vaccination of laboratory workers provided the opportunity to compare culture with polymerase chain reaction ( PCR) for the detection of F. tularensis in human clinical samples. Methods. Blood and skin swab samples were prospectively collected from volunteers who received the LVS tularemia vaccine at baseline ( negative controls) and at 5 specified time points ( days 1, 2, 7 or 8, 14 or 15, and 35 after vaccination). Bacterial culture and PCR of whole blood samples ( 17 volunteers) and inoculation site swabs ( 41 volunteers) were performed. Results. The culture and PCR results of all blood samples were negative. Results of real-time PCR from the inoculation site samples were positive for 41 ( 100%) of 41 volunteers on day 1, for 40 ( 97.6%) of 41 volunteers on day 2, for 24 ( 58.5%) of 41 on day 7 or 8, for 6 ( 16.7%) of 36 on day 14 or 15, and for 0 ( 0%) of 9 on day 35. Positive results of bacterial cultures of the inoculation site samples occurred significantly less frequently, compared with PCR testing, with 4 ( 9.8%) of 41 volunteers having positive results on day 1 (P < .001) and 4 ( 9.8%) of 41 on day 2 (P < .001); all results from subsequent days were negative. Conclusions. F. tularensis LVS genomic DNA was detected in the majority of samples from the inoculation site up to 1 week after LVS vaccination, with real-time PCR being more sensitive than culture. Our data suggest that bacteremia does not occur after LVS vaccination in normal, healthy human volunteers. C1 USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Diagnost Syst, Ft Detrick, MD 21702 USA. RP Hepburn, MJ (reprint author), PSC 281,Box 84, FPO, AE 09421 USA. EM matthew.hepburn@amedd.army.mil FU PHS HHS [Y1-A1-2663-D1] NR 18 TC 14 Z9 14 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD SEP 15 PY 2006 VL 43 IS 6 BP 711 EP 716 DI 10.1086/506348 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 077SI UT WOS:000240050000008 PM 16912944 ER PT J AU Somiari, SB Somiari, RI Heckman, CM Olsen, CH Jordan, RM Russel, SJ Shriver, CD AF Somiari, Stella B. Somiari, Richard I. Heckman, Caroline M. Olsen, Cara H. Jordan, Rick M. Russel, Stephen J. Shriver, Craig D. TI Circulating MMP2 and MMP9 in breast cancer - Potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE serum profiling; matrix metalloproteinase 2 and 9; breast cancer; breast disease; high risk; Gail model ID MATRIX METALLOPROTEINASES; COLORECTAL-CANCER; IV COLLAGENASE; MATRIX-METALLOPROTEINASE-9; PLASMA; BLOOD; METASTASIS; GELATINASE; CARCINOMA; MODEL AB Matrix metalloproteinase (MMP) 2 and 9 are involved in cancer invasion and metastasis, and increased levels occur in serum and plasma of breast cancer (BC) patients. It is, however, unclear whether changes in serum levels can be exploited for early detection or classification of patients into different risk/disease categories. In our study, we measured concentration and activity of MMP2/9 in sera of 345 donors classified as low risk (Gail score < 1.7), high risk (HR) (Gail score >= 1.7), benign disease or BC. Kruskal-Wallis and Mann-Whitney nonparametric tests showed that total-MMP2 concentration is higher in HR compared to control (p = 0.012), benign (p = 0.001) and cancer (p = 0.007). Active MMP2 (aMMP2) concentration is higher in control than benign and cancer (p < 0.001, respectively). Total and aMMP9 concentrations are higher in cancer than benign (p < 0.001, p = 0.002, respectively). Total-MMP2 and total-MMP9 activities are lower in control than benign (p < 0.001, p = 0.002, respectively) and cancer (p < 0.001, respectively). Total-MMP2 and MMP9 activities are also higher in cancer flan benign (p = 0.004, p < 0.001) and HR (p = 0.008, p = 0.007, respectively). These results were not affected by age or inclusion/exclusion of donors with noninvasive cancer or atypical hyperplasia. Linear discriminant analysis revealed that HR donors are characterized by lower total-MMP2 and higher aMMP2. Overall group classification accuracy was 64.5%. Independent validation based on the leave-one-out cross validation approach gave an overall classification of 63%. Our study provides evidence supporting the potential role of serum MMP2/9 as biomarkers for breast disease classification. (c) 2006 Wiley-Liss, Inc. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. ITSI Biosci, Funct Genom & Proteom Unit, Johnstown, PA USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Somiari, SB (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM s.somiari@wriwindber.org NR 40 TC 81 Z9 85 U1 0 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD SEP 15 PY 2006 VL 119 IS 6 BP 1403 EP 1411 DI 10.1002/ijc.21989 PG 9 WC Oncology SC Oncology GA 075ID UT WOS:000239877200026 PM 16615109 ER PT J AU Hopkins, MA Thorndike, AS AF Hopkins, Mark A. Thorndike, Alan S. TI Floe formation in Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SCALES LARGE; LEAD ICE; FRACTURE; MODEL AB [ 1] The ice pack covering northern seas is composed of a mixture of thick ridged and rafted ice, undeformed ice, and open water. Ice motions determined from satellite remote sensing data show that deformation of the pack takes place along the boundary of large floes. Eulerian continuum sea ice models can simulate this behavior to a degree by capturing the localization of gridded ice strength in some average sense. However, using a discontinuous Lagrangian approach that explicitly models ice floes and the interactions between them, it is possible to simulate both the fracture process that creates floe boundaries and the continued deformation along those floe boundaries. We have developed a granular model of the central Arctic ice pack that consists of thousands of individual grains that can freeze together, fracture apart, and interact through ridging. Accelerations produced by passing weather patterns and sustained quasi-steady deformation cause the model pack to fracture apart into floes composed of one or more grains. When the ice pack is nonuniformly accelerating due to passage of a weather pattern, simulations show that the factors that influence the size of the floes are the tensile strength of the joints between grains, the gradient of the wind field, and the average size of the individual grains. During sustained deformation the pack continues to deform along existing floe boundaries while stresses build and further fracture takes place. In quiet areas of the basin, fractures refreeze. To explore the fracture process during sustained deformation, we run 24-hour basin scale simulations at resolutions from 2.8 km to 14 km. At the end of each simulation we construct a distribution of floe areas. The cumulative distribution of floes at the large end of the distribution is approximately the same at each resolution. As we increase the resolution from 14 km to 2.8 km, the damage zones between large floes become more localized. A log-log plot of the cumulative floe size distributions obtained from the simulations appears linear over several orders of magnitude. C1 ERDC CRREL, Hanover, NH 03755 USA. Univ Puget Sound, Dept Phys, Tacoma, WA 98406 USA. RP Hopkins, MA (reprint author), ERDC CRREL, Hanover, NH 03755 USA. EM mark.a.hopkins@erdc.usace.army.mil NR 20 TC 19 Z9 21 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD SEP 13 PY 2006 VL 111 IS C11 AR C11S23 DI 10.1029/2005JC003352 PG 9 WC Oceanography SC Oceanography GA 086AL UT WOS:000240645400002 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, S. S. Xu, K. Jow, T. R. TI An improved electrolyte for the LiFePO4 cathode working in a wide temperature range SO JOURNAL OF POWER SOURCES LA English DT Article DE LiFePO4; LiBF4; lithium bis(oxalato)borate; ionic conductivity; low temperature performance; high temperature performance ID LI-ION CELLS; PROPYLENE CARBONATE; LIBOB; PERFORMANCE; SALT; BATTERIES AB A LiBF4-LiBOB (lithium bis(oxalato)borate) salt mixture was used to formulate an electrolyte for the operation of a LiFePO4 cathode over a wide temperature range (-50 to 80 degrees C) by employing a solvent mixture of 1:1:3 (wt.) propylene carbonate (PC)/ethylene carbonate (EC)/ethylmethyl carbonate (EMC). In comparison with the ionic conductivity of a single salt electrolyte, LiBF4 electrolyte has a higher conductivity below -10 degrees C while the LiBOB electrolyte is higher above -10 degrees C. For cell performance, LiBF4 cell has a better low temperature performance and a higher power capability, but it cannot survive above 60 degrees C. In contrast, the LiBOB cell performs very well at high temperature even up to 90 degrees C, but it fails to perform below -40 degrees C. We found that the temperature performance of Li/LiFePO4 cells could be optimized by using a LiBF4-LiBOB salt mixture. At 1C and at -50 degrees C, for example, a Li/LiFePO4 cell using 90:10 (in mole) LiBF4-LiBOB salt mixture could provide up to similar to 30% of capacity at similar to 3.0 V and it still could be cycled at 90 degrees C. In addition, we observed and explained an opposite correlation between the ionic conductivity of the electrolyte and the power capability of the cell. That is, the LiBF4 cell at 20 degrees C discharges at a higher plateau voltage than the LiBOB cell, whereas the LiBF4 electrolyte has a lower ionic conductivity. Published by Elsevier B.V. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 22 TC 53 Z9 70 U1 7 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 13 PY 2006 VL 159 IS 1 BP 702 EP 707 DI 10.1016/j.jpowsour.2005.11.042 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 091FK UT WOS:000241012000116 ER PT J AU Silver, JM Koumaras, B Chen, M Mirski, D Potkin, SG Reyes, P Warden, D Harvey, PD Arciniegas, D Katz, DI Gunay, I AF Silver, J. M. Koumaras, B. Chen, M. Mirski, D. Potkin, S. G. Reyes, P. Warden, D. Harvey, P. D. Arciniegas, D. Katz, D. I. Gunay, I. TI Effects of rivastigmine on cognitive function in patients with traumatic brain injury SO NEUROLOGY LA English DT Article ID ALZHEIMERS-DISEASE; SENILE DEMENTIA; HEAD-INJURY; ACETYLCHOLINE; INVENTORY; DEPRESSION; VALIDATION; DEFICITS AB Objective: To compare the efficacy and safety of rivastigmine (3 to 6 mg/day) vs placebo over 12 weeks in patients with traumatic brain injury and persistent cognitive impairment. Methods: This prospective, randomized, double-blind, placebo-controlled study was conducted in 157 patients at least 12 months after injury. The primary efficacy measures were the Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing (RVIP) A' subtest and the Hopkins Verbal Learning Test (HVLT). The primary efficacy outcome was the proportion of patients who demonstrated 1.0 SD or greater improvement from baseline at week 12 on CANTAB RVIP A' or HVLT. Results: The percentage of responders at week 12 on either the CANTAB RVIP A' or HVLT was 48.7% for rivastigmine and 49.3% for placebo (p = 0.940). Furthermore, for the overall study population, there were no significant differences for any of the secondary efficacy variables. In a subgroup of patients with moderate to severe memory impairment (n = 81), defined as 25% impairment or greater on HVLT at baseline, rivastigmine was significantly better than placebo for a number of measures, including the proportion of HVLT responders and CANTAB RVIP mean latency. Conclusions: Rivastigmine was safe and well tolerated in patients with traumatic brain injury with cognitive deficits. Rivastigmine shows promising results in the subgroup of patients with traumatic brain injury with moderate to severe memory deficits. C1 Novartis Pharmacuet, E Hanover, NJ 07936 USA. NYU, Sch Med, New York, NY 10021 USA. Univ Calif Irvine, Med Ctr, Orange, CA USA. Creighton Univ, Sch Med, Omaha, NE USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. CUNY Mt Sinai Sch Med, New York, NY 10029 USA. Univ Colorado, Hlth Sci Ctr, Denver, CO USA. Boston Univ, Sch Med, Boston, MA 02118 USA. Healths Braintree Rehabil Hosp, Braintree, MA USA. RP Gunay, I (reprint author), Novartis Pharmacuet, 1 Hlth Pl, E Hanover, NJ 07936 USA. EM ibrahim.gunay@novartis.com RI Arciniegas, David/A-3792-2009; Potkin, Steven/A-2021-2013 NR 25 TC 43 Z9 47 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD SEP 12 PY 2006 VL 67 IS 5 BP 748 EP 755 DI 10.1212/01.wnl.0000234062.98062.e9 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 083EC UT WOS:000240437700005 PM 16966534 ER PT J AU Tsen, KT Kiang, JG Ferry, DK Morkoc, H AF Tsen, K. T. Kiang, Juliann G. Ferry, D. K. Morkoc, H. TI Subpicosecond time-resolved Raman studies of LO phonons in GaN: Dependence on photoexcited carrier density SO APPLIED PHYSICS LETTERS LA English DT Article ID ALGAN/GAN CHANNEL; HOT; RELAXATION; TRANSPORT; GAAS AB Subpicosecond time-resolved Raman spectroscopy has been used to measure the lifetime of the LO phonon mode in GaN for photoexcited electron-hole pair density ranging from 10(16) to 2x10(19) cm(-3). The lifetime has been found to decrease from 2.5 ps, at low density, to 0.35 ps, at the highest density. The experimental findings should help resolve the recent controversy over the lifetime of LO phonon mode in GaN. (c) 2006 American Institute of Physics. C1 Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. Arizona State Univ, Dept Elect Engn, Tempe, AZ 85287 USA. Virginia Commonwealth Univ, Dept Phys, Richmond, VA 23284 USA. RP Tsen, KT (reprint author), Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. EM tsen@asu.edu NR 16 TC 77 Z9 77 U1 0 U2 21 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 11 PY 2006 VL 89 IS 11 AR 112111 DI 10.1063/1.2349315 PG 3 WC Physics, Applied SC Physics GA 084PI UT WOS:000240545400060 ER PT J AU Straight, TM Ottolini, MG Prince, GA Eichelberger, MC AF Straight, Timothy M. Ottolini, Martin G. Prince, Gregory A. Eichelberger, Maryna C. TI Evidence of a cross-protective immune response to influenza A in the cotton rat model SO VACCINE LA English DT Article DE influenza; cotton rat; heterosubtypic immunity ID HETEROSUBTYPIC IMMUNITY; HETEROTYPIC IMMUNITY; VIRUS-INFECTION; M2 PROTEIN; SIGMODON-HISPIDUS; MICE; PATHOGENESIS; VACCINATION; MECHANISMS; CHALLENGE AB Epidemiologic evidence suggests that cross-protective immune responses to influenza A viruses that have different hemagglutinin and neuraminidase subtypes occur in humans. This study characterized this heterosubtypic immunity in cotton rats (Sigmodon hispidus). Animals were infected with influenza A/PR/8/34 (H1N1)or A/Wuhan/359/95 (H3N2), and then challenged with A/Wuhan/359/95(H3N2) virus 4 weeks later. Viral titers, respiratory rates, and pathology of the respiratory tract following primary and secondary infection were compared. Cross-protection from heterosubtypic influenza A challenge in cotton rats was characterized by enhanced viral clearance, protection from tachypnea, a vigorous early cellular recall response, and a reduction in bronchiolar epithelial cell damage. Cross-protection was retained in steroid treated animals, in which the inflammatory recall response was minimal. Identification of the mechanisms that contribute to cross-protection in cotton rats may lead to the development of influenza vaccine strategies that are broadly protective. (c) 2006 Elsevier Ltd. All rights reserved. C1 Brooke Army Med Ctr, Dept Clin Investigat, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Virion Syst Inc, Rockville, MD 20850 USA. RP Straight, TM (reprint author), Brooke Army Med Ctr, Dept Clin Investigat, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM timothy.m.straight@us.army.mil; MarynaE@virionsystems.com NR 24 TC 23 Z9 26 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 11 PY 2006 VL 24 IS 37-39 BP 6264 EP 6271 DI 10.1016/j.vaccine.2006.05.092 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 086VX UT WOS:000240702200012 PM 16860444 ER PT J AU Costanzo, PJ Beyer, FL AF Costanzo, Philip J. Beyer, Frederick L. TI PMSE 315-Antimicrobial wool protein fibers with incorporation of aminopyridinium salts SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Costanzo, Philip J.] USA, Weap & Multifunct Mat, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Beyer, Frederick L.] USA, AMSRL WM MA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 223-PMSE BP 123 EP 123 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781700117 ER PT J AU Hong, HP Wensel, J Peterson, S Roy, W AF Hong, Haiping Wensel, Jesse Peterson, Shelley Roy, Walter TI PMSE 527-Characterizing chicken feather barbs as natural protein fibers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Hong, Haiping; Wensel, Jesse; Peterson, Shelley] S Dakota Sch Mines & Technol, Dept Mat & Met, Rapid City, SD 57701 USA. [Roy, Walter] USA, Res Lab, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 607-PMSE BP 443 EP 443 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781700434 ER PT J AU Napadensky, E Sloan, JM Crawford, DM AF Napadensky, Eugene Sloan, James M. Crawford, Dawn M. TI PMSE 28-Structural ordering in thin films of cylinder forming block copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Napadensky, Eugene; Sloan, James M.; Crawford, Dawn M.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 282-PMSE BP 519 EP 519 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781700510 ER PT J AU Nguyen, T Gu, XH VanLandingham, M Ryntz, R Martin, J AF Tinh Nguyen Gu, Xiaohong VanLandingham, Mark Ryntz, Rose Martin, Jonathan TI PMSE 322-Automatic online monitoring of copper mediated living radical polymerizations SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Tinh Nguyen; Gu, Xiaohong; Martin, Jonathan] NIST, Gaithersburg, MD 20899 USA. [VanLandingham, Mark] USA, Chief Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Ryntz, Rose] Visteon Corp, Dearborn, MI 48120 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 154-PMSE BP 555 EP 555 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781700546 ER PT J AU Dayan, FE Scheffler, B Arias, RS Michel, A Netherland, MD AF Dayan, Franck E. Scheffler, Brian Arias, Renee S. Michel, Albrecht Netherland, Michael D. TI Evolution of resistance to phytoene desaturase-inhibiting herbicides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Dayan, Franck E.] ARS, Nat Prod Utilizat Res Unit, USDA, University, MS 38677 USA. [Scheffler, Brian] ARS, USDA, CGRU, Stoneville, MS 38776 USA. [Arias, Renee S.] Oregon State Univ, Corvallis, OR 97331 USA. [Michel, Albrecht] Syngenta Crop Protect AG, Herbicide Profiling Biol, CH-4332 Stein, Switzerland. [Netherland, Michael D.] Univ Florida, Ctr Aquat & Invas Plants, USA, Engn Res & Dev Ctr, Gainesville, FL 32653 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 109-AGRO BP 618 EP 618 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781600561 ER PT J AU Banks, HD AF Banks, Harold D. TI ORGN 41-Study of the reaction of aziridine and its derivatives with ammonia: The profound influence of fluorine substituents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Banks, Harold D.] USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, AMSSB RRT TC, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 41-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781608268 ER PT J AU Barber, SM Costanzo, PJ Kuhl, TL Patten, TE AF Barber, Suzanne M. Costanzo, Philip J. Kuhl, Tonya L. Patten, Timothy E. TI POLY 22-Polymer-mediated self-assembly of nanoparticles and the use of magnetic particles to probe ligand-receptor interactions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Barber, Suzanne M.; Kuhl, Tonya L.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Costanzo, Philip J.] USA, Weap & Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Balko, Suzanne/K-2669-2014 OI Balko, Suzanne/0000-0002-9713-3349 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 22-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781701509 ER PT J AU Chordia, MD Smith, KS Smith, PL AF Chordia, Mahendra D. Smith, Kirsten S. Smith, Philip L. TI MEDI 562-Biological evaluation of 1-OH modified Ailanthinone analogs as antimalarial agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chordia, Mahendra D.; Smith, Kirsten S.; Smith, Philip L.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RI Chordia, Mahendra/A-4706-2008 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 562-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781607378 ER PT J AU Ciezak, JA Byrd, EFC Rice, BM AF Ciezak, Jennifer A. Byrd, Edward F. C. Rice, Betsy M. TI PHYS 350-Equation of state and structural changes in the energetic material CL-20: An experimental and theoretical study SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Ciezak, Jennifer A.; Byrd, Edward F. C.; Rice, Betsy M.] USA, AMSRD ARL WM BD, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 350-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781609037 ER PT J AU Fredrickson, HL Furey, JS Dortch, M Zakikhani, M Foote, C Sung-Chan, K Richmond, M AF Fredrickson, Herbert L. Furey, John S. Dortch, Mark Zakikhani, Mansour Foote, Chris Sung-Chan, Kim Richmond, Margaret TI DSTR 23-Chemical and microbiological indicators of environmental impacts around New Orleans due to hurricanes Katrina and Rita SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Fredrickson, Herbert L.; Dortch, Mark; Zakikhani, Mansour] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Furey, John S.; Foote, Chris; Sung-Chan, Kim] USAE Waterways Expt Stn, Environm Lab, Vicksburg, MS 39180 USA. [Richmond, Margaret] SpekPro, Environm Lab, Vicksburg, MS 39180 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 23-DSTR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781602811 ER PT J AU Harris, J AF Harris, Jeff TI DSTR 10-Hurricane Katrina overview SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Harris, Jeff] US Army Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 10-DSTR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781602815 ER PT J AU Kalainoff, MZ Riegner, DE Deloia, MA Lachance, RP Biaglow, AI AF Kalainoff, Melinda Z. Riegner, Dawn E. Deloia, Matthew A. Lachance, Russ P. Biaglow, Andrew I. TI CHED 160-Learning equilibrium chemistry using a systematic approach SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kalainoff, Melinda Z.; Riegner, Dawn E.; Deloia, Matthew A.; Lachance, Russ P.; Biaglow, Andrew I.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 160-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781602671 ER PT J AU Li, J Wang, L Hashimoto, Y Tsao, CY Wood, TK Valdes, JJ Zafiriou, E Bentley, WE AF Li, Jun Wang, Liang Hashimoto, Yoshifumi Tsao, Chen-Yu Wood, Thomas K. Valdes, James J. Zafiriou, Evanghelos Bentley, William E. TI BIOT 91-A stochastic model of E. coli AI-2 quorum sensing circuit reveals alternative synthesis pathways SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Li, Jun; Zafiriou, Evanghelos] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Wang, Liang] NIDDK, Biotechnol Core Lab, NIH, Bethesda, MD 20892 USA. [Hashimoto, Yoshifumi] Univ Maryland, Inst Biotechnol, CBR, College Pk, MD 20742 USA. [Tsao, Chen-Yu] Univ Maryland, Dept Chem Engn, UMBI, Ctr Biosyst Res, College Pk, MD 20742 USA. [Wood, Thomas K.] Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA. [Wood, Thomas K.] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA. [Wood, Thomas K.] Texas A&M Univ, Dept Civil Environm Engn, College Stn, TX 77843 USA. [Valdes, James J.] USA, Mol Engn Team, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 91-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781601664 ER PT J AU Mosurkal, R Tucci, V Samuelson, L Bruno, F Westmoreland, PR Kumar, J Watterson, AC AF Mosurkal, Ravi Tucci, Vincent Samuelson, Lynne Bruno, Ferdinando Westmoreland, Phillip R. Kumar, Jayant Watterson, Arthur C. TI POLY 533-Biocatalytic synthesis of organo-siloxane copolymers for flame retardant applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mosurkal, Ravi; Samuelson, Lynne; Bruno, Ferdinando] USA, Nanomat Sci Team, Natick Soldier Ctr, Natick, MA 01760 USA. [Tucci, Vincent; Watterson, Arthur C.] Univ Massachusetts Lowell, Dept Chem, Inst NanoSci & Engn Technol, Lowell, MA 01854 USA. [Westmoreland, Phillip R.] Univ Massachusetts Amherst, Dept Chem Engn, Goessmann Lab 159, Amherst, MA 01003 USA. [Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Dept Chem & Phys, Lowell, MA 01854 USA. [Watterson, Arthur C.] Univ Massachusetts Lowell, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. RI MOSURKAL, RAVI/P-6981-2015 NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 533-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781701310 ER PT J AU Nagarajan, S Nagarajan, R Cazeca, M Kumar, J Bruno, F Samuelson, L AF Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Cazeca, Mario Kumar, Jayant Bruno, Ferdinando Samuelson, Lynne TI POLY 529-Single-step biocatalytic synthesis of sexithiophene SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Nagarajan, Subhalakshmi] Univ Massachusetts Lowell, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. [Nagarajan, Ramaswamy; Cazeca, Mario; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. [Bruno, Ferdinando; Samuelson, Lynne] USA, Natick Soldier Ctr, Nanomat Sci Team, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 529-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DC UT WOS:000207781701344 ER PT J AU Rong, C Chu, D AF Rong, Charles Chu, Deryn TI PETR 120-Some cobalt based sorbents for hydrogen sulfide desulfurization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rong, Charles; Chu, Deryn] US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 120-PETR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781605619 ER PT J AU Steeves, DM Soares, JW AF Steeves, Diane M. Soares, Jason W. TI COLL 499-Surface modification of nanocrystalline ZnO: Effects on optical properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Steeves, Diane M.] US Army Res Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. [Soares, Jason W.] US Natick Soldier Ctr, MST SS, Natick, MA 01760 USA. [Soares, Jason W.] US Natick Soldier Ctr, TD, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 499-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781603455 ER PT J AU Tsao, CY Wang, L Yi, H Hashimoto, Y DeLisa, MP Wood, TK Valdes, JJ Bentley, WE AF Tsao, Chen-Yu Wang, Liang Yi, Hyunmin Hashimoto, Yoshifumi DeLisa, Matthew P. Wood, Thomas K. Valdes, James J. Bentley, William E. TI BIOT 2-Manipulating cells by tuning quorum signaling to enhance recombinant protein production in Escherichia coli SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Tsao, Chen-Yu] Univ Maryland, Dept Chem Engn, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. [Wang, Liang] NIDDK, Biotechnol Core Lab, NIH, Bethesda, MD 20892 USA. [Yi, Hyunmin] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. [Hashimoto, Yoshifumi] Univ Maryland, Inst Biotechnol, CBR, College Pk, MD 20742 USA. [DeLisa, Matthew P.] Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14853 USA. [Wood, Thomas K.] Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA. [Wood, Thomas K.] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA. [Wood, Thomas K.] Texas A&M Univ, Dept Civil Environm Engn, College Stn, TX 77843 USA. [Valdes, James J.] USA, Engn Res & Dev Ctr, Edgewood, MD USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 2-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781601673 ER PT J AU Zhang, MX Dave, PR Yang, K Duddu, RG Gelber, N Damavarapu, R Surapaneni, R AF Zhang, Mao-Xi Dave, Paritosh R. Yang, Kathy Duddu, Raja G. Gelber, Nathaniel Damavarapu, Reddy Surapaneni, Rao TI ORGN 468-A new approach to nitrotriazoles via 1,3-dipolar cycloaddition of nitroacetylene to azides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Zhang, Mao-Xi; Dave, Paritosh R.; Yang, Kathy; Duddu, Raja G.; Gelber, Nathaniel] SAIC, Picatinny Arsenal, NJ 07806 USA. [Gelber, Nathaniel; Damavarapu, Reddy; Surapaneni, Rao] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP 10 PY 2006 VL 232 MA 468-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V15DB UT WOS:000207781608590 ER PT J AU Williams, MR Fisher, TR Boynton, WR Cerco, CF Kemp, MW Eshleman, KN Kim, SC Hood, RR Fiscus, DA Radcliffe, GR AF Williams, M. R. Fisher, T. R. Boynton, W. R. Cerco, C. F. Kemp, M. W. Eshleman, K. N. Kim, S-C. Hood, R. R. Fiscus, D. A. Radcliffe, G. R. TI An integrated modelling system for management of the Patuxent River estuary and basin, Maryland, USA SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article; Proceedings Paper CT Conference on Studying Land Use Effects in Coastal Zones with Remote Sensing and GIS CY AUG 13-16, 2003 CL Kemer, TURKEY ID GLOBAL NITROGEN-CYCLE; LAND-USE CHANGE; CHESAPEAKE BAY; CONSEQUENCES; TRANSPORT; INPUTS AB The Patuxent River watershed is a heavily impacted basin (2290 km(2)) and estuarine tributary (120 km(2)) of the Chesapeake Bay, USA. To assist management of the basin, we are testing a coupled modelling system composed of a watershed model (HSPF), an estuarine circulation model (CH3D), and an estuarine water-quality model (CE-QUAL-ICM). The modelling system is being tested to guide the development of Total Maximum Daily Loads (TMDLs), and therefore errors in the models must be carefully evaluated. A comparison of daily total nitrogen (TN) concentrations simulated in HSPF with observations indicated that there was no significant bias, with an rms error of 37%. In contrast, modelled total phosphorus (TP) and total suspended solids (TSS) had significant bias with larger rms errors (65% and 259%, respectively). In the estuary, CH3D accurately simulated tides, temperature, and salinity. CE-QUAL-ICM overestimated nitrogen (N) and phosphorus (P) in the upper estuary and underestimated in the lower estuary, primarily because intertidal marshes are not currently a model component. Model errors declined from short (<= 1 day) to long (multi-year) timescales as under- and overestimations cumulatively cancelled. Watershed model errors propagate into the estuarine models, interacting with each subsequent model's errors, which limits the effectiveness of this TMDL management tool at short timescales. C1 Univ Maryland, Ctr Environm Studies, Horn Point Lab, Cambridge, MD 21613 USA. Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA. Ctr Res Dev & Engn, Waterways Expt Stn, Vicksburg, MS 39180 USA. Univ Maryland, Appalachian Lab, Ctr Environm Sci, Frostburg, MD 21532 USA. RP Williams, MR (reprint author), Univ Maryland, Ctr Environm Studies, Horn Point Lab, 2020 Horn Point Rd, Cambridge, MD 21613 USA. EM williams@hpl.umces.edu RI Boynton, Walter/C-3035-2012; hood, raleigh/F-9364-2013; Eshleman, Keith/J-6531-2015; OI Kemp, Michael/0000-0001-5989-0421 NR 23 TC 7 Z9 8 U1 2 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD SEP 10 PY 2006 VL 27 IS 17 BP 3705 EP 3726 DI 10.1080/01431160500500417 PG 22 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA 090LU UT WOS:000240953600007 ER PT J AU Brandt, HE Myers, JM AF Brandt, Howard E. Myers, John M. TI Expanded quantum cryptographic entangling probe SO JOURNAL OF MODERN OPTICS LA English DT Article AB A generalized quantum circuit and design are given for an optimal entangling probe to be used in attacking the BB84 protocol of quantum key distribution and yielding maximum information to the probe. Probe photon polarization states become optimally entangled with the BB84 signal states on their way between the legitimate transmitter and receiver. The present design generalizes an earlier one by Brandt [J. Mod. Optics 52 2177 (2005)] to include a complete range of error rates that can be induced by the probe. C1 USA, Res Lab, Adelphi, MD USA. Harvard Univ, Gordon McKay Lab, Cambridge, MA USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 3 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PD SEP 10 PY 2006 VL 53 IS 13 BP 1927 EP 1930 DI 10.1080/09500340600680041 PG 4 WC Optics SC Optics GA 069LM UT WOS:000239448000008 ER PT J AU Schure, MR Maier, RS AF Schure, Mark R. Maier, Robert S. TI How does column packing microstructure affect column efficiency in liquid chromatography? SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE simulation; fluid mechanics; zone broadening; packed column; microstructure; column efficiency ID PARTICLE DIAMETER RATIO; RADIAL-DISTRIBUTION; MAGNETIC-RESONANCE; FLOW VELOCITY; PACKED-BEDS; DISPERSION; SIMULATION; VISUALIZATION; PERFORMANCE; SPHERES AB Full three-dimensional computer simulations of the fluid flow and dispersion characteristics of model nonporous chromatographic packingsare reported. Interstitial porosity and packing defects are varied in an attempt to understand the chromatographic consequences of the packing microstructure. The tracer zone dispersion is calculated in the form of plate height as a function of fluid velocity for seven model particle packs where particles are selectively removed from the packs in clusters of varying size and topology. In an attempt to examine the consequences of loose but random packs, the velocities and zone dispersion of seven defect-free packs are simulated over the range 0.36 <= epsilon <= 0.50, where E is the interstitial porosity. The results indicate that defect-free loose packings can give good chromatographic efficiency but the efficiency can vary depending on subtle details of the pack. When the defect population increases, the zone dispersion increases accordingly. For a particle pack where 6% of the particles are removed from an epsilon = 0.36 pack, approximate to 33% of the column efficiency is lost. These results show that it is far more important in column packing to prevent defect sites leading to inhomogeneous packing rather than obtaining the highest density pack with the smallest interstitial void volume. (c) 2006 Elsevier B.V. All rights reserved. C1 Rohm & Haas Co, Theoret Separat Sci Lab, Spring House, PA 19477 USA. USA, Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. RP Schure, MR (reprint author), Rohm & Haas Co, Theoret Separat Sci Lab, 727 Norristown Rd,Box 0904, Spring House, PA 19477 USA. EM MSchure@Rohmhaas.com; S.Maier@erdc.usace.army.mil NR 56 TC 36 Z9 36 U1 2 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 EI 1873-3778 J9 J CHROMATOGR A JI J. Chromatogr. A PD SEP 8 PY 2006 VL 1126 IS 1-2 BP 58 EP 69 DI 10.1016/j.chroma.2006.05.066 PG 12 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 082KJ UT WOS:000240385200005 PM 16806247 ER PT J AU Nghiem, SV Chao, Y Neumann, G Li, P Perovich, DK Street, T Clemente-Colon, P AF Nghiem, S. V. Chao, Y. Neumann, G. Li, P. Perovich, D. K. Street, T. Clemente-Colon, P. TI Depletion of perennial sea ice in the East Arctic Ocean SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID POLARIMETRIC SIGNATURES; PHYSICAL-PROPERTIES; FRAM STRAIT; ALGORITHM; EXTENT; SHELF; COVER AB The extent of perennial sea ice in the East Arctic Ocean ( 0 - 180 degrees E) decreased by nearly one half with an abrupt reduction of 0.95 x 10(6) km(2), while the West Arctic Ocean (0 - 180 degrees W) had a slight gain of 0.23 x 10(6) km(2) between 2004 and 2005, as observed by satellite scatterometer data during November - December. The net decrease in the total perennial ice extent is 0.72 x 10(6) km(2), about the size of Texas. Perennial ice in the East Arctic Ocean continued to be depleted with an areal reduction of 70% from October 2005 to April 2006. With the East Arctic Ocean dominated by seasonal sea ice, a strong summer melt may open a vast ice-free region with a possible record minimum ice extent largely confined to the West Arctic Ocean. Simultaneous scatterometer measurements of sea ice and winds will be crucial for sea ice monitoring and forecasts. C1 CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. Natl Ice Ctr, Washington, DC 20385 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Nghiem, SV (reprint author), CALTECH, Jet Prop Lab, MS 300-325,4800 Oak Grove Dr, Pasadena, CA 91109 USA. EM son.v.nghiem@jpl.nasa.gov RI Clemente-Colon, Pablo/F-5581-2010 NR 36 TC 51 Z9 51 U1 1 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD SEP 7 PY 2006 VL 33 IS 17 AR L17501 DI 10.1029/2006GL027198 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 082WE UT WOS:000240417100008 ER PT J AU Bennett, MD Leo, DJ Wilkes, GL Beyer, FL Pechar, TW AF Bennett, Matthew D. Leo, Donald J. Wilkes, Garth L. Beyer, Frederick L. Pechar, Todd W. TI A model of charge transport and electromechanical transduction in ionic liquid-swollen Nafion membranes SO POLYMER LA English DT Article DE electroactive polymer; charge transport; IPMC ID POLYMER-METAL COMPOSITES; PERFLUORINATED IONOMER MEMBRANES; X-RAY-SCATTERING; ARTIFICIAL MUSCLES; ELECTROLYTE COMPOSITES; BIOMIMETIC SENSORS; WATER DIFFUSION; ACTUATORS; HYDRATION; DEVICES AB Ionomeric polymer transducers (sometimes called "ionic polymer-metal composites," or "IPMCs") are a class of electroactive polymers that are able to operate as distributed electromechanical actuators and sensors. Traditionally, these transducers have been fabricated using water-swollen Nation membranes. This work seeks to overcome the hydration dependence of these transducers by replacing water with an ionic liquid. In the current work, two ionic liquids are studied as diluents for ionomeric polymer transducers based on Nation membranes. The two ionic liquids used are 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EMI-Tf) and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (EMI-Im). These two ionic liquids were chosen for their low viscosity and high conductivity. Furthermore, although many of the physical properties of the two ionic liquids are similar, the EMI-Tf ionic liquid is water miscible whereas the EMI-Im ionic liquid is hydrophobic. These important similarities and differences facilitated investigations of the interactions between the ionic liquids and the Nation polymer. This paper examines the mechanisms of electromechanical transduction in ionic liquid-swollen transducers based on Nafion polymer membranes. Specifically, the morphology and relevant ion associations within these membranes are investigated by the use of small-angle X-ray scattering (SAXS), Fourier transform infrared (FTIR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. These results reveal that the ionic liquid interacts with the membrane in much the same way that water does, and that the counterions of the Nation polymer are the primary charge carriers in the ionic liquid-swollen films. The results of these analyses are compared to the macroscopic transduction behavior in order to develop a molecular/morphological model of the charge transport mechanism responsible for electromechanical coupling in these membranes. (c) 2006 Elsevier Ltd. All rights reserved. C1 Virginia Tech, Ctr Intelligent Mat Syst & Struct, Dept Mech Engn, Blacksburg, VA 24061 USA. Virginia Tech, Polymer Mat & Interfaces Lab, Dept Chem Engn, Blacksburg, VA 24061 USA. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Bennett, MD (reprint author), Virginia Tech, Ctr Intelligent Mat Syst & Struct, Dept Mech Engn, 310 Durham Hall, Blacksburg, VA 24061 USA. EM mabenne2@vt.edu NR 56 TC 78 Z9 78 U1 2 U2 40 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD SEP 7 PY 2006 VL 47 IS 19 BP 6782 EP 6796 DI 10.1016/j.polymer.2006.07.061 PG 15 WC Polymer Science SC Polymer Science GA 093MG UT WOS:000241171800039 ER PT J AU Pando, MA Eyzaguirre, LM Segura, M Bautista, CT Marone, R Ceballos, A Montano, SM Sanchez, JL Weissenbacher, M Avila, MM Carr, JK AF Pando, Maria A. Eyzaguirre, Lindsay M. Segura, Marcela Bautista, Christian T. Marone, Ruben Ceballos, Ana Montano, Silvia M. Sanchez, Jose L. Weissenbacher, Mercedes Avila, Maria M. Carr, Jean K. TI First report of an HIV-1 triple recombinant of subtypes B, C and F in Buenos Aires, Argentina SO RETROVIROLOGY LA English DT Article ID TYPE-1 AB We describe the genetic diversity of currently transmitted strains of HIV-1 in men who have sex with men ( MSM) in Buenos Aires, Argentina between 2000 and 2004. Nearly full-length sequence analysis of 10 samples showed that 6 were subtype B, 3 were BF recombinant and 1 was a triple recombinant of subtypes B, C and F. The 3 BF recombinants were 3 different unique recombinant forms. Full genome analysis of one strain that was subtype F when sequenced in pol was found to be a triple recombinant. Gag and pol were predominantly subtype F, while gp120 was subtype B; there were regions of subtype C interspersed throughout. The young man infected with this strain reported multiple sexual partners and sero-converted between May and November of 2004. This study reported for the first time the full genome analysis of a triple recombinant between subtypes B, C and F, that combines in one virus the three most common subtypes in South America. C1 Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Ctr Nacl Referencia SIDA, RA-1121 Buenos Aires, DF, Argentina. Univ Maryland, Biotechnol Inst, Inst Human Virol, Dept Epidemiol, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA. Henry M Jackson Fdn Adv Mil Med Inc, Rockville, MD 20850 USA. Nexo Asociac Civil, RA-1022 Buenos Aires, DF, Argentina. USN, Med Res Ctr Detachment, Unit 3800, APO AA, Lima, Peru. Walter Reed Army Inst Res, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. RP Pando, MA (reprint author), Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Ctr Nacl Referencia SIDA, Paraguay 2155,Piso 11, RA-1121 Buenos Aires, DF, Argentina. EM mpando@umbi.umd.edu; eyzaguir@umbi.umd.edu; msegura2004@yahoo.com.ar; cbautista@hivresearch.org; rmarone@nexo.org; aceballo@fmed.uba.ar; Smontano@nmrcd.med.navy.mil; sanchezjl@amedd.army.mil; mweissen@fmed.uba.ar; mavila@fmed.uba.ar; carrj@umbi.umd.edu RI Bautista, Christian/B-2812-2011 NR 11 TC 9 Z9 9 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 7 PY 2006 VL 3 AR 59 DI 10.1186/1742-4690-3-59 PG 5 WC Virology SC Virology GA 088NR UT WOS:000240818900001 PM 16959032 ER PT J AU Doona, CJ Feeherry, FE Baik, MY AF Doona, Christopher J. Feeherry, Florence E. Baik, Moo-Yeol TI Water dynamics and retrogradation of ultrahigh pressurized wheat starch SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE ultrahigh pressure processing; wheat starch; gelatinization; retrogradation; proton mobility; NMR; DSC ID HIGH HYDROSTATIC-PRESSURE; TREATED STARCH; WHITE BREAD; INACTIVATION; TEMPERATURE; GELATINIZATION; DIGESTIBILITY; TRANSITION; GLYCEROL; GRANULES AB The water dynamics and retrogradation kinetics behavior of gelatinized wheat starch by either ultrahigh pressure (UHP) processing or heat are investigated. Wheat starch completely gelatinized in the condition of 90000 psi at 25 C for 30 min (pressurized gel) or 100 C for 30 min (heated gel). The physical properties of the wheat starches were characterized in terms of proton relaxation times (T-2 times) measured using time-domain nuclear magnetic resonance spectroscopy and evaluated using commercially available continuous distribution modeling software. Different T-2 distributions in both micro- and millisecond ranges between pressurized and heated wheat starch gels suggest distinctively different water dynamics between pressurized and heated wheat starch gels. Smaller water self-diffusion coefficients were observed for pressurized wheat starch gels and are indicative of more restricted translational proton mobility than is observed with heated wheat starch gels. The physical characteristics associated with changes taking place during retrogradation were evaluated using melting curves obtained with differential scanning calorimetry. Less retrogradation was observed in pressurized wheat starch, and it may be related to a smaller quantity of freezable water in pressurized wheat starch. Starches comprise a major constituent of many foods proposed for commercial potential using UHP, and the present results furnish insight into the effect of UHP on starch gelatinization and the mechanism of retrogradation during storage. C1 Kyung Hee Univ, Dept Food Sci & Biotechnol, Inst Life Sci & Resources, Yongin, South Korea. USA, Combat Feeding Innovat Sci Team, Natick Soldier Ctr, RDECOM, Natick, MA 01760 USA. RP Baik, MY (reprint author), Kyung Hee Univ, Dept Food Sci & Biotechnol, Inst Life Sci & Resources, Yongin, South Korea. EM mooyeol@khu.ac.kr OI Baik, Moo-Yeol/0000-0003-3779-3369 NR 34 TC 16 Z9 19 U1 1 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD SEP 6 PY 2006 VL 54 IS 18 BP 6719 EP 6724 DI 10.1021/jf061104h PG 6 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 078UL UT WOS:000240129700033 PM 16939331 ER PT J AU Carroll, EE Hammamieh, R Chakraborty, N Phillips, AT Miller, SAM Jett, M AF Carroll, Erica E. Hammamieh, Rasha Chakraborty, Nabarun Phillips, Aaron T. Miller, Stacy-Ann M. Jett, Marti TI Altered gene expression in asymptomatic SHIV-infected rhesus macaques (Macacca mulatta) SO VIROLOGY JOURNAL LA English DT Article ID HIV-1; MACROPHAGES; MONKEYS; CCR5 AB Simian-Human immunodeficiency virus is a chimeric virus which, in rhesus macaques (Macacca mulatta) closely imitates immunodeficiency virus infection in human (HIV). A relatively new way to study pathogenesis of viral infection is to study alterations in host gene expression induced by the virus. SHIV infection with certain strains does not result in clinical signs. We hypothesized that alterations in gene expression relating to the immune system would be present in SHIV-infected animals despite the lack of clinical signs. Splenic tissue from four adult male Indian-origin Rhesus monkeys serologically positive for non-pathogenic SHIV 89.6 was processed by cDNA microarray analysis. Results were compared with the corresponding outcome using splenic tissues from four unexposed adult male Rhesus monkeys. Subsequent gene analysis confirmed statistically significant variations between control and infected samples. Interestingly, SHIV-infected monkeys exhibited altered expression in genes related to apoptosis, signal transduction, T and B lymphocyte activation and importantly, to immune regulation. Although infected animals appeared asymptomatic, our study demonstrated that SHIV-infected monkeys cannot reliably be used in studies of other infectious agents as their baseline gene expression differs from that of normal Rhesus monkeys. The gene expression differences in SHIV-infected animals relative to uninfected animals offer additional clues to the pathogenesis of altered immune function in response to secondary infection. C1 Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. EM Erica.Carroll@afip.osd.mil; rasha.hammamieh@na.amedd.army.mil; nabarun.chakraborty@na.amedd.army.mil; aaron.phillips@na.amedd.army.mil; stacy-ann.miller@na.amedd.army.mil; marti.jett@na.amedd.army.mil NR 15 TC 2 Z9 2 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD SEP 6 PY 2006 VL 3 AR 74 DI 10.1186/1743-422X-3-74 PG 8 WC Virology SC Virology GA 182LY UT WOS:000247507300002 PM 16956415 ER PT J AU Romero, CM DeShazer, D Feldblyum, T Ravel, J Woods, D Kim, HS Yu, Y Ronning, CM Nierman, WC AF Romero, Claudia M. DeShazer, David Feldblyum, Tamara Ravel, Jacques Woods, Donald Kim, H. Stanley Yu, Yan Ronning, Catherine M. Nierman, William C. TI Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts SO BMC GENOMICS LA English DT Article ID DNA-POLYMERASE-IV; ESCHERICHIA-COLI; BACILLUS-ANTHRACIS; REPEATS; GLANDERS; REPLICATION; EVOLUTION; GENES; POLYMORPHISMS; MECHANISM AB Background: More than 12,000 simple sequence repeats (SSRs) have been identified in the genome of Burkholderia mallei ATCC 23344. As a demonstrated mechanism of phase variation in other pathogenic bacteria, these may function as mutable loci leading to altered protein expression or structure variation. To determine if such alterations are occurring in vivo, the genomes of various single-colony passaged B. mallei ATCC 23344 isolates, one from each source, were sequenced from culture, a mouse, a horse, and two isolates from a single human patient, and the sequence compared to the published B. mallei ATCC 23344 genome sequence. Results: Forty-nine insertions and deletions (indels) were detected at SSRs in the five passaged strains, a majority of which (67.3%) were located within noncoding areas, suggesting that such regions are more tolerant of sequence alterations. Expression profiling of the two human passaged isolates compared to the strain before passage revealed alterations in the mRNA levels of multiple genes when grown in culture. Conclusion: These data support the notion that genome variability upon passage is a feature of B. mallei ATCC23344, and that within a host B. mallei generates a diverse population of clones that accumulate genome sequence variation at SSR and other loci. C1 Inst Genom Res, Rockville, MD 20850 USA. USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. Univ Calgary, Hlth Sci Ctr, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada. George Washington Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC 20037 USA. RP Ronning, CM (reprint author), Inst Genom Res, 9712 Med Ctr Dr, Rockville, MD 20850 USA. EM cromero@mail.ucf.edu; david.deshazer@us.army.mil; Tamara.Feldblyum@fda.hhs.gov; jravel@tigr.org; woods@ucalgary.ca; hstanleykim@yahoo.com; yyu@tigr.org; cronning@tigr.org; wnierman@tigr.org RI Ravel, Jacques/D-2530-2009; OI Ravel, Jacques/0000-0002-0851-2233 FU NIAID NIH HHS [N01AI30071, R01 AI050565, R01 AI056006, R01AI50565, R01AI56006, U01AI49037A] NR 45 TC 17 Z9 18 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD SEP 5 PY 2006 VL 7 AR 228 DI 10.1186/1471-2164-7-228 PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 087HD UT WOS:000240732600002 PM 16953889 ER PT J AU Wang, YP Yang, K Kim, SC Nagarajan, R Samuelson, LA Kumar, J AF Wang, Yanping Yang, Ke Kim, Seong-Cheol Nagarajan, Ramaswamy Samuelson, Lynne A. Kumar, Jayant TI In situ polymerized carboxylated diacetylene as a hole conductor in solid- state dye-sensitized solar cells SO CHEMISTRY OF MATERIALS LA English DT Article ID CONJUGATED POLYMERS; ELECTRODES C1 Univ Massachusetts Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. USA, Natick Soldier Ctr, RDECOM, Nanomat Sci Team, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. EM jayant_kumar@uml.edu NR 13 TC 33 Z9 35 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD SEP 5 PY 2006 VL 18 IS 18 BP 4215 EP 4217 DI 10.1021/cm0609045 PG 3 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 078AB UT WOS:000240072000004 ER PT J AU Akozbek, N Trushin, SA Baltuska, A Fuss, W Goulielmakis, E Kosma, K Krausz, F Panja, S Uiberacker, M Schmid, WE Becker, A Scalora, M Bloemer, M AF Akoezbek, N. Trushin, S. A. Baltuska, A. Fuss, W. Goulielmakis, E. Kosma, K. Krausz, F. Panja, S. Uiberacker, M. Schmid, W. E. Becker, A. Scalora, M. Bloemer, M. TI Extending the supercontinuum spectrum down to 200 nm with few-cycle pulses SO NEW JOURNAL OF PHYSICS LA English DT Article ID FEMTOSECOND LASER-PULSES; WHITE-LIGHT CONTINUUM; SELF-COMPRESSION; OPTICAL MEDIA; MOVING FOCUS; AIR; GENERATION; INTENSE; PROPAGATION; FILAMENTATION AB By focusing 805 nm pulses of low energy ( 0.2 - 1 mJ) into atmospheric- pressure argon, a supercontinuum is generated with a short-wavelength cutoff of 640, 250 and 210 nm for initial pulse durations of 45, 10 and 6 fs, respectively. It is shown numerically that the large shift of the UV cutoff and many features of the spectrum are caused by terms beyond the slowly- varying-envelope approximation ( SVEA). Their effect on pulse compression and filament length is also discussed. C1 Max Planck Inst Quantum Opt, D-85748 Garching, Germany. Time Domain Corp, Huntsville, AL 35806 USA. Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany. USA, Missile Command, Ctr Res Dev & Engn, Charles M Bowden Res Ctr, Redstone Arsenal, AL 35898 USA. RP Fuss, W (reprint author), Max Planck Inst Quantum Opt, D-85748 Garching, Germany. EM neset.akozbek@timedomain.com; w.fuss@mpq.mpg.de RI Goulielmakis, Eleftherios/F-1693-2011; Becker, Andreas/K-4402-2013 OI Goulielmakis, Eleftherios/0000-0003-3386-0245; NR 53 TC 40 Z9 40 U1 0 U2 13 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1367-2630 J9 NEW J PHYS JI New J. Phys. PD SEP 5 PY 2006 VL 8 AR 177 DI 10.1088/1367-2630/8/9/177 PG 12 WC Physics, Multidisciplinary SC Physics GA 084AG UT WOS:000240503300001 ER PT J AU Hoge, CW Castro, CA AF Hoge, Charles W. Castro, Carl A. TI Post-traumatic stress disorder in UK and US forces deployed to Iraq SO LANCET LA English DT Letter ID HEALTH C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Washington, DC USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Washington, DC USA. EM charles.hoge@na.amedd.army.mil NR 2 TC 29 Z9 29 U1 0 U2 2 PU LANCET LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0140-6736 J9 LANCET JI Lancet PD SEP 2 PY 2006 VL 368 IS 9538 BP 837 EP 837 DI 10.1016/S0140-6736(06)69315-X PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 082FD UT WOS:000240371200017 PM 16950349 ER PT J AU Wei, Q Zhang, HT Schuster, BE Ramesh, KT Valiev, RZ Kecskes, LJ Dowding, RJ Magness, L Cho, K AF Wei, Q. Zhang, H. T. Schuster, B. E. Ramesh, K. T. Valiev, R. Z. Kecskes, L. J. Dowding, R. J. Magness, L. Cho, K. TI Microstructure and mechanical properties of super-strong nanocrystalline tungsten processed by high-pressure torsion SO ACTA MATERIALIA LA English DT Article DE nanocrystalline; tungsten; grain boundaries; transmission electron microscopy; high-pressure torsion ID SEVERE PLASTIC-DEFORMATION; DUCTILE-BRITTLE TRANSITION; ULTRAFINE GRAIN SIZES; SINGLE-CRYSTALS; POLYCRYSTALLINE TUNGSTEN; NANOSTRUCTURED MATERIALS; METALLIC GLASSES; SHEAR BANDS; STRAIN-RATE; BEHAVIOR AB Fully dense nanocrystalline tungsten (nc-W) with extremely high strength (similar to 3.0 GPa under quasi-static compression and similar to 4.0 GPa under dynamic compression) has been obtained by high-pressure torsion (HPT) at low temperature (500 degrees C). The nanocrystalline microstructure is revealed by transmission electron microscopy (TEM). The grain boundaries (GBs) are mostly of the large-angle type. Highresolution TEM (lattice images) suggests that the GBs are clean and well defined (atomically sharp). GBs are non-equilibrium and of a high-energy nature. Edge dislocations are present within the grains. The authors hypothesize that these edge dislocations, combined with a depleted impurity concentrations along pre-existing GBs, contribute to enhance the ductility of nc-W. Under dynamic compression, the specimens exhibit localized shearing followed by cracking and subsequent failure, similar to their ultrafine-grain (UFG) counterparts processed by equal-channel angular pressing plus cold rolling, and to many other body-centered cubic metals with UFG/nanocrystalline microstructures. The shear band width in the HPT-processed nc-W is much smaller (shear band width < 5 mu m) than that observed in the UFG counterparts (shear band width similar to 40 mu m). (c) 2006 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. Johns Hopkins Univ, CAMCS, Baltimore, MD 21218 USA. US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. Ufa State Aviat Tech Univ, Ufa 450000, Russia. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014; Dowding, Robert/F-1469-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; Dowding, Robert/0000-0002-4763-2131 NR 57 TC 141 Z9 145 U1 13 U2 93 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD SEP PY 2006 VL 54 IS 15 BP 4079 EP 4089 DI 10.1016/j.actamat.2006.05.005 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 079JJ UT WOS:000240171600024 ER PT J AU Andrews, AH Cash, BD Lee, DH Saad, R Rai, J Maydonovitch, C Kim, CH Chey, WD AF Andrews, Allan H. Cash, Brooks D. Lee, Dong H. Saad, Richard Rai, Jennifer Maydonovitch, Corinne Kim, Cecilia H. Chey, William D. TI The high false positive rate of inflammatory bowel disease serologic markers in patients with irritable bowel syndrome SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-College-of-Gasroenterology CY OCT 20-25, 2006 CL Las Vegas, NV SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. Natl Naval Med Ctr, Div Gastroenterol, Bethesda, MD USA. Univ Michigan, Med Ctr, Div Gastroenterol, Ann Arbor, MI 48109 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2006 VL 101 IS 9 SU S MA 1226 BP S475 EP S476 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 086EH UT WOS:000240656102227 ER PT J AU Chey, WD Andrews, AH Lee, DH Smith, JH Kim, CH Saad, RJ Rai, JK Cash, BD AF Chey, William D. Andrews, Allan H. Lee, Dong H. Smith, John H. Kim, Cecilia H. Saad, Richard J. Rai, Jennifer K. Cash, Brooks D. TI Are anti-endomysial or anti-tissue transglutaminase antibodies alone sufficient to screen for celiac sprue in patients with the irritable bowel syndrome? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-College-of-Gasroenterology CY OCT 20-25, 2006 CL Las Vegas, NV SP Amer Coll Gastroenterol C1 Univ Michigan, Ann Arbor, MI 48109 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. Naval Med Ctr Portsmouth, Portsmouth, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2006 VL 101 IS 9 SU S MA 1232 BP S477 EP S478 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 086EH UT WOS:000240656102233 ER PT J AU Norris, WE Choi, R Goldwire, F Hwang, I Pak, J Maydonovitch, C Brazaitis, MP Wong, RKH AF Norris, William E. Choi, Richard Goldwire, Franklin Hwang, Inku Pak, Jennifer Maydonovitch, Corrine Brazaitis, Michael P. Wong, Roy K. H. TI Correlation between polyps detected on virtual colonoscopy (VC) vs. optical colonoscopy (OC) for colorectal cancer screening (CRC) in newly trained radiologists SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-College-of-Gasroenterology CY OCT 20-25, 2006 CL Las Vegas, NV SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2006 VL 101 IS 9 SU S MA 492 BP S209 EP S209 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 086EH UT WOS:000240656100493 ER PT J AU Parker, CW Liveringhouse, JD Fincher, RK AF Parker, Calvin W., III Liveringhouse, John D. Fincher, Roger K. TI Retrograde esophageal stent placement via a gastrostomy site as a treatment for Boerhaave's syndrome SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-College-of-Gasroenterology CY OCT 20-25, 2006 CL Las Vegas, NV SP Amer Coll Gastroenterol C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2006 VL 101 IS 9 SU S MA 877 BP S351 EP S351 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 086EH UT WOS:000240656101370 ER PT J AU Folta, SC Bell, R Economos, C Landers, S Goldberg, JP AF Folta, Sara C. Bell, Rick Economos, Christina Landers, Stewart Goldberg, Jeanne P. TI Psychosocial factors associated with young elementary school children's intentions to consume legumes: A test of the theory of reasoned action SO AMERICAN JOURNAL OF HEALTH PROMOTION LA English DT Article DE legumes; children; theory of reasoned action ID PREVENTION; PULSES; FRUIT AB Objective. The purpose of this study was to test the utility of the Theory of Reasoned Action (TRA) in explaining young elementary school children's intention to consume legumes. Methods. A survey was conducted with children in an urban, multicultural community in Massachusetts. A total of 336 children participated. Logistic regression analysis was used to assess the strength of the relationship between attitude and subjective norm and intention. Results. Although attitude was significantly associated with intention, the pseudo-R-2 for the regression model that included only the TRA constructs was extremely low (.01). Adding demographic factors and preference improved the model's predictive ability, but attitude was no longer significant. Conclusion. The results of this study do not provide support for the predictive utility of the TRA with young elementary school children for this behavior, when demographic factors are accounted for. Hedonic factors, rather than reasoned judgments, may help drive children's intentions. C1 Tufts Univ, Sch Nutr Sci & Policy, Boston, MA 02111 USA. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. John Snow Inc, Boston, MA USA. Tufts Univ, Sch Med, Dept Publ Hlth & Family Med, Boston, MA 02111 USA. RP Folta, SC (reprint author), Tufts Univ, Sch Nutr Sci & Policy, 150 Harrison Ave, Boston, MA 02111 USA. EM sara.folta@tufts.edu NR 10 TC 2 Z9 2 U1 1 U2 2 PU AMER J HEALTH PROMOTION INC PI KEEGO HARBOR PA 1660 CASS LAKE RD, STE 104, KEEGO HARBOR, MI 48320 USA SN 0890-1171 J9 AM J HEALTH PROMOT JI Am. J. Health Promot. PD SEP-OCT PY 2006 VL 21 IS 1 BP 13 EP 15 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 083IH UT WOS:000240449100004 PM 16977908 ER PT J AU Brundage, JF AF Brundage, John F. TI Cases and deaths during influenza pandemics in the United States SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID MORTALITY; VIRUS AB Objective: To assess how numbers and age distributions of cases and deaths during an influenza pandemic in the United States would potentially vary from those during the 1918-1919 pandemic, given the same virulence of the pandemic strain. Methods: Influenza cases and deaths in two referent populations (U.S. residents in 1917 and 2006) were calculated using clinical case rates from three pandemics (1918-like, 1957-like, and 1968-like) and case fatality rates from the 1918-1919 pandemic. Results: Across pandemic scenarios, overall case ("attack") rates ranged from 24.7% to 34.2%, and overall death rates ranged from 4.4 to 6.7 per 1000. In both referent populations, total cases and deaths were significantly higher when using 1957-like and 1968-like, compared to 1918-like, case rates. Under all pandemic scenarios, the most deaths occurred among those aged 25 to 29 years. However, in the 2006 referent population, there were large numbers and high proportions of deaths in middle-aged and elderly adults (unlike during the 1918-1919 pandemic). Conclusions: Numbers and distributions of cases and deaths during influenza pandemics depend on numbers of individuals, clinical case rates, and case fatality rates in relation to age. During a future pandemic in the United States, influenza deaths will likely not be as sharply focused in young adults as in 1918-1919 (even if case fatality rates are similar) because of larger proportions of middle-aged and elderly adults and potentially higher case rates among adults older than 30. C1 USA, Ctr Hlth Promot & Prevent Med, Army Med Surveillance Act, Directorate Epidemiol & Dis Surveillance, Washington, DC 20307 USA. RP Brundage, JF (reprint author), USA, Ctr Hlth Promot & Prevent Med, Army Med Surveillance Act, Directorate Epidemiol & Dis Surveillance, Bldg T-20,Room 213,6900 Georgia Ave NW, Washington, DC 20307 USA. EM john.brundage@amedd.army.mil NR 12 TC 26 Z9 26 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD SEP PY 2006 VL 31 IS 3 BP 252 EP 256 DI 10.1016/j.amepre.2006.04.005 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 077QM UT WOS:000240044800009 PM 16905037 ER PT J AU Chew, FS Banks, KP AF Chew, Felix S. Banks, Kevin P. TI Imaging of pheochromocytoma and incidental adrenal lesions: Self-assessment module SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE adrenal gland; genitourinary imaging; kidney; pheochromocytoma AB The educational objectives for this self-assessment module on imaging of pheochromocytoma and incidental adrenal lesions are for the participant to exercise, self-assess, and improve his or her knowledge of the imaging evaluation of pheochromocytoma and incidental adrenal lesions. C1 Univ Washington, Dept Radiol, Seattle, WA 98105 USA. Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. RP Chew, FS (reprint author), Univ Washington, Dept Radiol, Box 354755,4245 Roosevelt Way NE, Seattle, WA 98105 USA. EM fchew@u.washington.edu OI Chew, Felix/0000-0003-2711-2013 NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2006 VL 187 IS 3 SU S BP S467 EP S469 DI 10.2214/AJR.06.0521 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 082RU UT WOS:000240405700003 ER PT J AU Colby, GW Banks, KP Torres, E AF Colby, Garrett W. Banks, Kevin P. Torres, Ernesto TI AJR teaching file: Incidental adrenal mass and hypertension SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE abdominal imaging; cancer; CT; MRI; pheochromocytoma ID OF-THE-ART; PHEOCHROMOCYTOMA C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Univ Alabama, Sch Med, Birmingham, AL USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, MCHE-DR,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Kevin.Banks@cen.amedd.army.mil NR 6 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2006 VL 187 IS 3 SU S BP S470 EP S472 DI 10.2214/AJR.05.0903 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 082RU UT WOS:000240405700004 PM 16928899 ER PT J AU Shideler, RM Banks, KP Torres, E AF Shideler, R. Mark Banks, Kevin P. Torres, Ernesto TI AJR teaching file: Persistent epigastric pain SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE abdominal imaging; barium studies; gastrointestinal radiology; lymphoma; stomach ID GASTRIC-CARCINOMA; TUMORS C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Third Med Grp, Elmendorf AFB, AK 99506 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, MCHE-DR,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Kevin.Banks@amedd.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2006 VL 187 IS 3 SU S BP S480 EP S482 DI 10.2214/AJR.05.1117 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 082RU UT WOS:000240405700007 PM 16928901 ER PT J AU Jaffin, AW Maniscalco-Theberge, M AF Jaffin, Annesley W. Maniscalco-Theberge, Mary TI Career resource - Military practice SO AMERICAN JOURNAL OF SURGERY LA English DT Article C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Jaffin, AW (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM Info@WomenSurgeons.org NR 0 TC 1 Z9 1 U1 0 U2 0 PU EXCERPTA MEDICA INC PI BRIDGEWATER PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD SEP PY 2006 VL 192 IS 3 BP 403 EP 406 DI 10.1016/j.amjsurg.2006.04.015 PG 4 WC Surgery SC Surgery GA 079LD UT WOS:000240176900025 PM 16920440 ER PT J AU Hill, DR Baird, JK Parise, ME Lewis, LS Ryan, ET Magill, AJ AF Hill, David R. Baird, J. Kevin Parise, Monica E. Lewis, Linda S. Ryan, Edward T. Magill, Alan J. TI Primaquine: Report from CDC expert meeting on malaria chemoprophylaxis I SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Review ID PLASMODIUM-VIVAX MALARIA; PNEUMOCYSTIS-CARINII PNEUMONIA; PLACEBO-CONTROLLED TRIAL; NONIMMUNE COLOMBIAN SOLDIERS; DRUG-INDUCED ENDOCYTOSIS; HUMAN LIVER-MICROSOMES; ANTI-RELAPSE THERAPY; ANTIMALARIAL-DRUGS; TRIMETHOPRIM-SULFAMETHOXAZOLE; INDUCED METHEMOGLOBINEMIA AB Primaquine phosphate has been used for preventing relapse of Plasmodium vivax and P. ovate malaria since the early 1950s, based on its ability to kill latent (hypnozoite) and developing liver stages of these parasites. There are three uses for primaquine in malaria: radical cure of established infection with P. vivax or P. ovate malaria; presumptive anti-relapse therapy (PART; terminal prophylaxis) in persons with extensive exposure to these parasites; and primary prophylaxis against all malaria species. All persons for whom primaquine is being considered must have a glucose-6-phosphate dehydrogenase (G6PD) enzyme level checked before use, and persons who have a deficiency of G6PD must not take primaquine for prophylaxis or PART. The recommended adult dose for PART based on clinical trials and expert opinion is 30 mg base daily for 14 days, started on return from a malarious region and overlapping with a blood schizonticide. The adult dose for primary prophylaxis is 30 mg daily begun 1 day before travel and continued for 7 days after return. This review will examine the evidence for these recommendations. C1 Natl Travel Hlth Network, DTM&H, London WC1E 6AU, England. London Sch Hyg & Trop Med, London WC1E 6AU, England. ALERTAsia Fdn, Jakarta 10430, Indonesia. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, US Publ Hlth Serv, Atlanta, GA 30341 USA. Butte Cty Dept Publ Hlth, Oroville, CA 95965 USA. Massachusetts Gen Hosp, Trop & Geog Med Ctr, Div Infect Dis, Boston, MA 02114 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Hill, DR (reprint author), Natl Travel Hlth Network, DTM&H, Capper St, London WC1E 6AU, England. EM david.hill@uclh.org NR 170 TC 148 Z9 152 U1 0 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2006 VL 75 IS 3 BP 402 EP 415 PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 083RR UT WOS:000240476400006 PM 16968913 ER PT J AU Bergmann-Leitner, ES Duncan, EH Mullen, GE Burge, JR Khan, F Long, CA Angov, E Lyon, JA AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Mullen, Gregory E. Burge, John Robert Khan, Farhat Long, Carole A. Angov, Evelina Lyon, Jeffrey A. TI Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; PARASITE PLASMODIUM-FALCIPARUM; MEROZOITE SURFACE PROTEIN-1; IN-VITRO; INHIBITION; GROWTH; INVASION; ERYTHROCYTE; SCHIZONTS; IMMUNITY AB Antibodies are thought to be the primary immune effectors in the defense against erythrocytic stage Plasmodium falciparum. Thus, malaria vaccines directed to blood stages of infection are evaluated based on their ability to induce antibodies with anti-parasite activity. Such antibodies may have different effector functions (e.g., inhibition of invasion or inhibition of parasite growth/development) depending on the target antigen. We evaluated four methods with regards to their ability to differentiate between invasion and/or growth inhibitory activities of antibodies specific for two distinct blood stage antigens: AMA1. and MSP1(42). We conclude that antibodies induced by these vaccine candidates have different modes of action that vary not only by the antigen, but also by the strain of parasite being tested. Analysis based on parasitemia and viability was essential for defining the full range of anti-parasite activities in immune sera. C1 Walter Reed Army Inst Res, Dept Immunol, CD&I, Silver Spring, MD 20910 USA. NIAID, Malaria Vaccine Dev Branch, NIH, Rockville, MD 20852 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Dept Immunol, CD&I, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM bergmannleitner@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 27 TC 57 Z9 57 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2006 VL 75 IS 3 BP 437 EP 442 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 083RR UT WOS:000240476400011 PM 16968918 ER PT J AU Cable, BB Mair, EA AF Cable, Benjamin B. Mair, Eric A. TI Pediatric functional endoscopic sinus surgery: Frequently asked questions SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE paranasal sinus; pediatric endoscopic sinus surgery; sinusitis ID FACIAL GROWTH; RETROSPECTIVE ANALYSIS; SURGICAL-MANAGEMENT; ANTIBIOTIC-THERAPY; CONTROLLED-TRIAL; CHILDREN; ADENOIDECTOMY; RHINOSINUSITIS; EFFICACY; DISEASE AB Pediatric endoscopic sinus surgery is a controversial procedure that has evolved considerably over the past 2 decades. We present a current review of the literature regarding the treatment of children with refractory sinusitis with a focus on the use of endoscopic sinus surgery. Preoperative evaluation, surgical technique, postoperative care, and unusual applications are discussed. C1 Tripler Army Med Ctr, Dept Pediat Otolaryngol, Honolulu, HI 96859 USA. Charlotte EENT Associates, Div Pediat Otolaryngol, Charlotte, NC USA. RP Cable, BB (reprint author), Tripler Army Med Ctr, Dept Pediat Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 61 TC 4 Z9 5 U1 0 U2 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2006 VL 115 IS 9 BP 643 EP 657 PG 15 WC Otorhinolaryngology SC Otorhinolaryngology GA 086KH UT WOS:000240671700001 PM 17044535 ER PT J AU Roth, JE Conner, WC Porisch, ME Shry, E AF Roth, Jason E. Conner, William C. Porisch, Mary E. Shry, Eric TI Sinoatrial nodal artery to right atrium fistula after myxoma excision SO ANNALS OF THORACIC SURGERY LA English DT Article ID CORONARY-ARTERY AB Acquired coronary artery to cardiac chamber fistulas are rare. Angiographically detectable neovascularization associated with a cardiac myxoma occurs frequently. These vessels are incorporated into the atrial suture line during surgical excision. We describe the case of a patient with a symptomatic right coronary artery to right atrial fistula that had occurred 4 years after left atrial myxoma resection. These large vessels should be considered for ligation during the myxoma resection. C1 Brooke Army Med Ctr, Dept Cardiol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Cardiothorac Surg, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Div Pediat Cardiol, Lackland AFB, TX 78236 USA. RP Roth, JE (reprint author), Brooke Army Med Ctr, Serv Cardiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jason.roth@amedd.army.mil NR 7 TC 5 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD SEP PY 2006 VL 82 IS 3 BP 1106 EP 1107 DI 10.1016/j.athoracsur.2006.01.067 PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA 076ZD UT WOS:000239996300058 PM 16928553 ER PT J AU Moon, JE Ellis, MW Griffith, ME Hawley, JS Rivard, RG McCall, S Hospenthal, DR Murray, CK AF Moon, James E. Ellis, Michael W. Griffith, Matthew E. Hawley, Joshua S. Rivard, Robert G. McCall, Suzanne Hospenthal, Duane R. Murray, Clinton K. TI Efficacy of macrolides and telithromycin against leptospirosis in a hamster model (vol 50, pg 1989, 2006) SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Correction C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Moon, JE (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2006 VL 50 IS 9 BP 3231 EP 3231 DI 10.1128/AAC.00811-06 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 081DI UT WOS:000240297000063 ER PT J AU Kim, CM Yi, YH Yu, DH Lee, MJ Cho, MR Desai, AR Shringi, S Klein, TA Kim, HC Song, JW Back, LJ Chong, ST O'Guinn, ML Lee, JS Lee, IY Park, JH Foley, J Chae, JS AF Kim, Chul-Min Yi, Ying-Hua Yu, Do-Hyeon Lee, Mi-Jin Cho, Mae-Rim Desai, Atul R. Shringi, Smriti Klein, Terry A. Kim, Heung-Chul Song, Jin-Won Back, Luck-Ju Chong, Sung-Tae O'Guinn, Monica L. Lee, John S. Lee, In-Yong Park, Jin-Ho Foley, Janet Chae, Joon-Seok TI Tik-borne-borne rickettsial pathogens in ticks and small mammals in Korea SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; EHRLICHIA-PHAGOCYTOPHILA GENOGROUP; HUMAN GRANULOCYTIC EHRLICHIOSIS; DEER ODOCOILEUS-VIRGINIANUS; IXODES-RICINUS TICKS; REAL-TIME PCR; ANAPLASMA-PHAGOCYTOPHILUM; BORRELIA-BURGDORFERI; MOLECULAR-DETECTION; ETIOLOGIC AGENT AB In order to investigate the prevalence of tick-borne infectious agents among ticks, ticks comprising five species from two genera (Hemaphysalis spp. and Ixodes spp.) were screened using molecular techniques. Ticks (3,135) were collected from small wild-caught mammals or by dragging/flagging in the Republic of Korea (ROK) and were pooled into a total of 1,638 samples (1 to 27 ticks per pool). From the 1,638 tick samples, species-specific fragments of Anaplasma phagocytophilum (1 sample), Anaplasma platys (52 samples), Ehrlichia chaffeensis (29 samples), Ehrlichia ewingii (2 samples), Ehrlichia canis (18 samples), and Rickettsia rickettsii (28 samples) were amplified by PCR assay. Twenty-one pooled and individual tick samples had mixed infections of two (15 samples) or three (6 samples) pathogens. In addition, 424 spleen samples from small captured mammals (389 rodents, 33 insectivores, and 2 weasels) were screened for selected zoonotic pathogens. Species-specific DNA fragments of A. phagocytophilum (110 samples), A. platys (68 samples), E. chaffeensis (8 samples), E. ewingii (26 samples), E. canis (51 samples), and Rickettsia sp. (22 samples) were amplified by PCR assay. One hundred thirty small mammals had single infections, while 4, 14, and 21 striped field mice (Apodemus agrarius) had mixed infections of four, three, and two pathogens, respectively. Phylogenetic analysis based on nucleotide sequence comparison also revealed that Korean strains of E. chaffeensis clustered closely with those from China and the United States, while the Rickettsia (rOmpA) sequences clustered within a clade together with a Chinese strain. These results suggest that these agents should be considered in differential diagnosis while examining cases of acute febrile illnesses in humans as well as animals in the ROK. C1 Univ Calif Davis, Ctr Vector Borne Dis, Dept Vet Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA. Force Hlth Promot, APO, AP 96205 USA. Chonbuk Natl Univ, Coll Vet Med, Jeonju 561756, South Korea. 18th Med Command, Med Battalion AS 168th, Med Detachment 5th, Unit 15247, APO, AP 96205 USA. Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. USA, Med Res Inst Infect Dis, Dept Virol, Ft Detrick, MD 21702 USA. Yonsei Univ, Coll Med, Dept Parasitol, Seoul 120749, South Korea. RP Chae, JS (reprint author), Univ Calif Davis, Ctr Vector Borne Dis, Dept Vet Med & Epidemiol, Sch Vet Med, 1 Shields Ave, Davis, CA 95616 USA. EM jschae@ucdavis.edu NR 54 TC 63 Z9 68 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD SEP PY 2006 VL 72 IS 9 BP 5766 EP 5776 DI 10.1128/AEM.00431-06 PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 083QT UT WOS:000240474000011 PM 16957192 ER PT J AU Schiffman, JM Bensel, CK Hasselquist, L Gregorczyk, KN Piscitelle, L AF Schiffman, Jeffrey M. Bensel, Carolyn K. Hasselquist, Leif Gregorczyk, Karen N. Piscitelle, Louis TI Effects of carried weight on random motion and traditional measures of postural sway SO APPLIED ERGONOMICS LA English DT Article DE military load carriage; reliability; stabilogram-diffusion analysis ID ENERGY-EXPENDITURE; LOAD CARRIAGE; BALANCE; WALKING AB The purpose of the study was to investigate the effects of load weight carried by soldiers upon postural sway. Fourteen US Army enlisted men participated. Postural sway and muscle activity were measured while participants stood on a force plate. The load weight conditions, comprised of Army clothing and load-carriage equipment were 6, 16, and 40kg. With an increase in load weight, stabilogram-diffusion analysis revealed that random movement of postural sway decreased. Also, with an increase in load weight, center of pressure excursions increased linearly but muscle activity changed minimally. In short, increasing load weight challenged the load carriers' stability, reduced the randomness of postural sway and required the load carriers to exert greater control of the load in order to maintain balance. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Natick Soldier Ctr, Natick, MA 01760 USA. RP Schiffman, JM (reprint author), USA, Natick Soldier Ctr, 45 Kansas St Bldg 3, Natick, MA 01760 USA. EM Jeffrey.Schiffman@natick.army.mil NR 20 TC 29 Z9 31 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 J9 APPL ERGON JI Appl. Ergon. PD SEP PY 2006 VL 37 IS 5 BP 607 EP 614 DI 10.1016/j.apergo.2005.10.002 PG 8 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA 073CW UT WOS:000239721200005 PM 16356467 ER PT J AU Schilling, BW Chinn, SR Hays, AD Goldberg, L Trussell, CW AF Schilling, Bradley W. Chinn, Stephen R. Hays, A. D. Goldberg, Lew Trussell, C. Ward TI End-pumped 1.5 mu m monoblock laser for broad temperature operation SO APPLIED OPTICS LA English DT Article ID ND-YAG LASER; LENS DUCTS; DIODE BAR; EFFICIENT; ARRAY; APERTURE AB We describe a next-generation monoblock laser capable of a greater than 10 mJ, 1.5 mu m output at 10 pulses/s (pps) over broad ambient temperature extremes with no active temperature control. The transmitter design is based on a Nd:YAG laser with a Cr4+ passive Q switch and intracavity potassium titanyl phosphate optical parametric oscillator. To achieve the repetition rate and efficiency goals of this effort, but still have wide temperature capability, the Nd:YAG slab is end pumped with a 12-bar stack of 100 W (each) diode bars. Different techniques for focusing the pump radiation into the 4.25 mm X 4.25 mm end of the slab are compared, including a lensed design, a reflective concentrator, and a lens duct. A wide temperature operation (-20 degrees C to 50 degrees C) for each end-pumped configuration is demonstrated. (c) 2006 Optical Society of America. C1 USA, RDECOM, NVESD, Ft Belvoir, VA 22060 USA. RP Schilling, BW (reprint author), USA, RDECOM, NVESD, Ft Belvoir, VA 22060 USA. EM bradley.schilling@nvl.army.mil NR 18 TC 15 Z9 17 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 1 PY 2006 VL 45 IS 25 BP 6607 EP 6615 DI 10.1364/AO.45.006607 PG 9 WC Optics SC Optics GA 079ZR UT WOS:000240216900039 PM 16912803 ER PT J AU Thomas, A Sands, D Baum, D To, L Rubel, GO AF Thomas, Ann Sands, David Baum, Dave To, Leleng Rubel, Glenn O. TI Emission wavelength dependence of fluorescence lifetimes of bacteriological spores and pollens SO APPLIED OPTICS LA English DT Article AB Concern about biological terrorism has greatly increased in the 21st century, and correspondingly, so has the need for accurate detection and identification of biological hazards, such as Bacillus anthracis. Optical techniques have been shown to be useful for this purpose. Use of fluorescence lifetimes as a function of emission wavelength for different materials using point-detection methods appears to be an additional viable option. Although the lifetimes range only between 2 and 6 ns, most biological materials tested in this study were distinguishable. A preliminary database has been compiled for use in a possible future detection system. (c) 2006 Optical Society of America. C1 Goucher Coll, Dept Phys, Baltimore, MD 21204 USA. Goucher Coll, Dept Biol Sci, Baltimore, MD 21204 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Thomas, A (reprint author), Goucher Coll, Dept Phys, 1021 Dulaney Valley Rd, Baltimore, MD 21204 USA. EM rgbaum@verizon.net NR 12 TC 3 Z9 3 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 1 PY 2006 VL 45 IS 25 BP 6634 EP 6639 DI 10.1364/AO.45.006634 PG 6 WC Optics SC Optics GA 079ZR UT WOS:000240216900043 PM 16912807 ER PT J AU Daum, LT Canas, LC Klimov, AI Shaw, MW Gibbons, RV Shrestha, SK Myint, KS Acharya, RP Rimal, N Reese, F Niemeyer, DM Arulanandam, BP Chambers, JP AF Daum, L. T. Canas, L. C. Klimov, A. I. Shaw, M. W. Gibbons, R. V. Shrestha, S. K. Myint, K. S. Acharya, R. P. Rimal, N. Reese, F. Niemeyer, D. M. Arulanandam, B. P. Chambers, J. P. TI Molecular analysis of isolates from influenza B outbreaks in the US and Nepal, 2005 SO ARCHIVES OF VIROLOGY LA English DT Article ID VIRUS; HEMAGGLUTININS; EVOLUTION; LINEAGES; SEASONS AB Currently circulating influenza B viruses can be divided into two antigenically and genetically distinct lineages referred to by their respective prototype strains, B/Yamagata/16/88 and B/Victoria/2/87, based on amino acid differences in the hemagglutinin surface glycoprotein. During May and July 2005, clinical specimens from two early season influenza B outbreaks in Arizona and southeastern Nepal were subjected to antigenic (hemagglutinin inhibition) and nucleotide sequence analysis of hemagglutinin (HA1), neuraminidase (NA), and NB genes. All isolates exhibited little reactivity with the B/Shanghai/361/2002 (B/Yamagata-like) vaccine strain and significantly reduced reactivity with the previous 2003/04 B/Hong Kong/330/2001 (B/Victoria-like) vaccine strain. The majority of isolates were antigenically similar to B/Hawaii/33/2004, a B/Victoria-like reference strain. Sequence analysis indicated that 33 of 34 isolates contained B/Victoria-like HA and B/Yamagata-like NA and NB proteins. Thus, these outbreak isolates are both antigenically and genetically distinct from the current Northern Hemisphere vaccine virus strain as well as the previous 2003-04 B/Hong Kong/330/2001 (B/Victoria lineage) vaccine virus strain but are genetically similar to B/Malaysia/2506/2004, the vaccine strain proposed for the coming seasons in the Northern and Southern Hemispheres. Since these influenza B outbreaks occurred in two very distant geographical locations, these viruses may continue to circulate during the 2006 season, underscoring the importance of rapid molecular monitoring of HA, NA and NB for drift and reassortment. C1 USAF, Inst Operat Hlth, US Dept Def, Brooks AFB, TX 78235 USA. Univ Texas, AFIT, San Antonio, TX 78285 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Armed Forces Res Inst Med Sci, Army Med Component, Bangkok 10400, Thailand. Walter Reed AFRIMS Res Unit Nepa, WARUN, Kathmandu, Nepal. Assoc Med Doctors Asia Nepal, Kathmandu, Nepal. USAF, Off Surgeon Gen, Modernizat Directorate, Falls Church, VA USA. RP Daum, LT (reprint author), USAF, Inst Operat Hlth, US Dept Def, 2503 Gillingham,175 West, Brooks AFB, TX 78235 USA. EM luke.daum@brooks.af.mil RI Arulanandam, Bernard/O-9501-2014 NR 18 TC 7 Z9 8 U1 0 U2 0 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PD SEP PY 2006 VL 151 IS 9 BP 1863 EP 1874 DI 10.1007/s00705-006-0777-0 PG 12 WC Virology SC Virology GA 073EE UT WOS:000239725000014 PM 16736092 ER PT J AU Deane, KD Hueber, W Majka, DS Tomooka, BH Gilliland, WR Parrish, LA Parish, MC Norris, JM Robinson, WH Holers, VM AF Deane, Kevin D. Hueber, Wolfgang Majka, Darcy S. Tomooka, Beren H. Gilliland, William R. Parrish, Lezlie A. Parish, Mark C. Norris, Jill M. Robinson, William H. Holers, V. Michael TI Specific cytokine and chemokine increases precede the appearance of anti-cyclic citrullinated protein (Anti-CCP) antibodies and rheumatoid factor (RF) in the pre-clinical period of rheumatoid arthritis (RA) development. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY NOV 10-15, 2006 CL Washington, DC SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 Univ Colorado, Denver, CO 80202 USA. Stanford Univ, Palo Alto, CA 94304 USA. Northwestern Univ, Chicago, IL 60611 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Stanford Univ, Palo Alto Vet Adm Hosp, Palo Alto, CA 94304 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2006 VL 54 IS 9 SU S BP S508 EP S508 PG 1 WC Rheumatology SC Rheumatology GA 089JR UT WOS:000240877202356 ER PT J AU Heinlen, LD McClain, MT Bruner, BF Edgerton, C Rubertone, M Harley, JB James, JA AF Heinlen, Latisha D. McClain, Micah T. Bruner, Benjamin F. Edgerton, Colin Rubertone, Mark Harley, John B. James, Judith A. TI The onset of autoantibodies prior to SLE diagnosis displays the complexity of lupus humoral autoimmunity and suggests early roles for specific autoantigens. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY NOV 10-15, 2006 CL Washington, DC SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2006 VL 54 IS 9 SU S BP S564 EP S564 PG 1 WC Rheumatology SC Rheumatology GA 089JR UT WOS:000240877203084 ER PT J AU Kyttaris, VC Juang, YT Tsokos, GC AF Kyttaris, Vasileios C. Juang, Yuang-Taung Tsokos, George C. TI NF-AT differentially regulates IL-2 and CD-40L transcription in T cells from patients with SLE. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY NOV 10-15, 2006 CL Washington, DC SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2006 VL 54 IS 9 SU S BP S754 EP S754 PG 1 WC Rheumatology SC Rheumatology GA 089JR UT WOS:000240877204189 ER PT J AU Lieberman, HR Niro, P Tharion, WJ Nindl, BC Castellani, JW Montain, SJ AF Lieberman, Harris R. Niro, Philip Tharion, William J. Nindl, Bradley C. Castellani, John W. Montain, Scott J. TI Cognition during sustained operations: Comparison of a laboratory simulation to field studies SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE vigilance; sleep deprivation; food deprivation; military; disaster relief; reaction time; memory ID CAFFEINE MAINTAINS VIGILANCE; SLEEP-DEPRIVATION; PHYSICAL PERFORMANCE; ACTIVE WAKEFULNESS; D-AMPHETAMINE; MOOD; STRESS; TYROSINE; PHENTERMINE; DECREMENTS AB Introduction: Military operations, especially combat, expose individuals to multiple stressors, including sleep loss, food deprivation, and sustained physical activity. Civilians, such as woodland firefighters, disaster victims, and relief workers, are also exposed to such environments. Our laboratory developed a brief, intense, laboratory-based simulation of a multistressor environment which included sleep loss, continuous physical activity, and food deprivation. Methods: During this sustained operations (SUSOPS) scenario, and a control period, cognitive performance and mood were measured in 13 volunteers. The scenario included road marches, battle drills, and land navigation. Physical activity and sleep were assessed with actigraphs. Results: Significant decrements in visual vigilance, choice reaction time, and matching-to-sample, a test of short-term memory, were observed. Marksmanship was stable and physical activity significantly increased. Mood states assessed by the Profile of Mood States (POMS: Tension, Depression, Anger, Vigor, Fatigue and Confusion) also significantly deteriorated. Discussion: Cognitive function declined more extensively and rapidly than physical performance. Decrements in cognitive performance were comparable to those in a field study conducted for an equivalent period of time in uncontrolled conditions. This demonstrates that decrements in cognitive function and increased physical activity, similar to those in highly stressful field environments, can be duplicated under controlled conditions. The simulated SUSOPS scenario is an appropriate paradigm for assessment of adverse effects of military and civilian multistressor environments on human performance, physiology, and interventions designed to mitigate them. C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Bldg 42, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil NR 38 TC 30 Z9 31 U1 0 U2 8 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2006 VL 77 IS 9 BP 929 EP 935 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 081CW UT WOS:000240295800006 PM 16964742 ER PT J AU Shearer, JF Jackson, MA AF Shearer, Judy F. Jackson, Mark A. TI Liquid culturing of microsclerotia of Mycoleptodiscus terrestris, a potential biological control agent for the management of hydrilla SO BIOLOGICAL CONTROL LA English DT Article DE Mycoleptodiscus terrestris; Hydrilla verticillata; hydrilla; bioherbicide; microsclerotia; sporulation ID FUNGAL PATHOGEN; COLLETOTRICHUM-TRUNCATUM; VERTICILLATA; GERMINATION AB Mycoleptodiscus terrestris has potential as an inundative biological control agent for the management of hydrilla, one of the world's worst aquatic weeds. Essential to producing a marketable bioherbicidal product was the development of liquid culture procedures that would yield propagules that maintained biocontrol efficacy. Since M. terrestris did not produce conidia in liquid culture, various nutritional conditions were evaluated as a means to produce high concentrations of stable fungal propagules such as microsclerotia. Evaluations of propagule formation and biomass yield were carried out in liquid culture media containing a basal salts solution amended with corn steep liquor powder or cottonseed meal combined with 4% or 6% glucose. Hyphal aggregation was observed by day 2, and by day 8 abundant melanized microsclerotia were present in the broth cultures. When applied as a liquid inoculum to hydrilla at rates of 0.1 and 0.2 ml/l, the microsclerotial matrix was capable of significantly reducing hydrilla shoot biomass by as much as 99%. Air-dried microsclerotia were capable of hyphal germination in 24 h and sporogenic germination in 72 h. These capabilities have significance for the use of microsclerotia of M. terrestris as the preferred inoculum for biocontrol purposes. Hyphae germinating from microsclerotia on hydrilla plant surfaces can establish initial infection sites followed several days later by secondary infections resulting from the development and release of spores from the surface of the microsclerotia. The capability of microsclerotia of M. terrestris to remain stable as a dry preparation and to germinate both hyphally and sporogenically upon rehydration enhances the potential of this fungus for use as a nonchemical, biological control agent for hydrilla. (c) 2006 Elsevier Inc. All rights reserved. C1 USA, Corps Engineers, ERDC, Vicksburg, MS 39180 USA. USDA ARS, Crop Bioprotect Res Unit, Natl Ctr Agr Utilizat Res, Peoria, IL 61604 USA. RP Shearer, JF (reprint author), USA, Corps Engineers, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Judy.F.Shearer@erdc.usace.army.mil NR 38 TC 26 Z9 28 U1 3 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 J9 BIOL CONTROL JI Biol. Control PD SEP PY 2006 VL 38 IS 3 BP 298 EP 306 DI 10.1016/j.biocontrol.2006.04.012 PG 9 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 078CA UT WOS:000240077600004 ER PT J AU Wu, F Zhang, XQ Cheung, JY Shi, KB Liu, ZW Luo, C Yin, S Ruffin, P AF Wu, Fei Zhang, Xueqian Cheung, Joseph Y. Shi, Kebin Liu, Zhiwen Luo, Claire Yin, Stuart Ruffin, Paul TI Frequency division multiplexed multichannel high-speed fluorescence confocal microscope SO BIOPHYSICAL JOURNAL LA English DT Article ID NA+/CA2+ EXCHANGER; MYOCYTES AB In this article, we report a new type of fluorescence confocal microscope: frequency division multiplexed multichannel fluorescence confocal microscope, in which we encode the spatial location information into the frequency domain. In this microscope, the exciting laser beam is first split into multiple beams and each beam is modulated at a different frequency. These multiple beams are focused at different locations of the target to form multiple focal points, which further generate multiple fluorescent emission spots. The fluorescent emissions from different focal points are also modulated at different frequencies, because the exciting beams are modulated at different frequencies (or difference carrier frequency). Then, all the fluorescent emissions (modulated at different frequencies) are collected together and detected by a highly sensitive, large-dynamic-range photomultiplier tube. By demodulating the detected signal (i.e., via the Fourier transform), we can distinguish the fluorescent light emitted from the different locations by the corresponding carrier frequencies. The major advantage of this unique fluorescence confocal microscope is that it not only has a high sensitivity because of the use of photomultiplier tube but also can get multiple-point data simultaneously, which is crucial to study the dynamic behavior of many biological process. As an initial step, to verify the feasibility of the proposed multichannel confocal microscope, we have developed a two-channel confocal fluorescence microscope and applied it to study the dynamic behavior of the changes of the calcium ion concentration during the single cardiac myocyte contraction. Our preliminary experimental results demonstrated that we could indeed realize multichannel confocal fluorescence microscopy by utilizing the frequency division multiplexed microscope, which could become an effective tool to study the dynamic behavior of many biological processes. C1 Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA. Penn State Univ, Coll Med, Dept Med, Hershey, PA USA. Gen Opto Solut LLC, State Coll, PA USA. USA, Aviat & Missile Command, Redstone Arsenal, AL USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu RI Shi, Kebin/D-3656-2009 NR 15 TC 16 Z9 19 U1 0 U2 8 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD SEP PY 2006 VL 91 IS 6 BP 2290 EP 2296 DI 10.1529/biophysj.106.083337 PG 7 WC Biophysics SC Biophysics GA 078US UT WOS:000240130500034 PM 16815894 ER PT J AU Taylor, JA Koff, SG Dauser, DA McLeod, DG AF Taylor, John A., III Koff, Stacey G. Dauser, Deborah A. McLeod, David G. TI The relationship of ultrasensitive measurements of prostate-specific antigen levels to prostate cancer recurrence after radical prostatectomy SO BJU INTERNATIONAL LA English DT Article DE PSA; ultrasensitive analysis; recurrence; prostate cancer ID ASSAY; RELAPSE; PSA; TIME AB OBJECTIVE To evaluate ultrasensitive (US) measurements of prostate-specific antigen (PSA) level in men with prostate cancer, and to correlate the findings with currently accepted values for PSA recurrence, as PSA is widely accepted as a surrogate marker for disease recurrence after treatment for prostate cancer, and although USPSA assays can detect minute quantities of PSA, the significance of this is unclear. PATIENTS AND METHODS In all, 225 patients had a radical prostatectomy (RP) and were followed with USPSA measurements. PSA recurrence was defined as two or more consecutive increasing PSA values after RP of >= 0.200 ng/mL. This was deemed clinically significant if it was associated with adjuvant treatment with a repeated nadir PSA level, or a PSA level that continued to increase on watchful waiting. USPSA values were compared between patients who recurred and those who did not, to determine any association with PSA recurrence and clinical outcomes. RESULTS There was a PSA recurrence in 21 patients; all had clinical evidence of recurrence. Although the difference in mean USPSA levels was statistically significant for those patients who did and did not recur, the overlap in values invalidated any clinical utility. However, an undetectable level achieved during the follow-up appeared to confer a favourable prognosis. CONCLUSION After RP patients might have PSA levels detectable by USPSA assays, i.e. < 0.1 ng/mL. The amount of 'background noise' produced within this range precludes the ability to use this test as a clinical indicator of disease recurrence. However, undetectable levels appear to confer a favourable prognosis. C1 Univ Connecticut, Ctr Hlth, Div Urol, Farmington, CT 06030 USA. Univ Connecticut, Ctr Hlth, Gen Clin Res Ctr, Farmington, CT 06030 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Taylor, JA (reprint author), Univ Connecticut, Ctr Hlth, Div Urol, 263 Farmington Ave,MC 3955, Farmington, CT 06030 USA. EM jtaylor@uchc.edu NR 13 TC 17 Z9 19 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1464-4096 J9 BJU INT JI BJU Int. PD SEP PY 2006 VL 98 IS 3 BP 540 EP 543 DI 10.1111/j.1464-410X.2006.06294.x PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 079SZ UT WOS:000240199500015 PM 16925750 ER PT J AU Trevino, G Andreas, EL AF Trevino, George Andreas, Edgar L. TI Dynamical implications of block averaging SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Reynolds averaging; zero integral scale ID SURFACE-LAYER TURBULENCE; NONSTATIONARY TURBULENCE AB We show that traditional Reynolds (block) averaging produces turbulence statistics whose time evolution is incompatible with the Navier-Stokes equation. Specifically, the zero integral scale that block averaging always produces leads to a trivial (zero-equals-zero) solution of the Navier-Stokes equation for autocovariances. We suggest alternative methods for analyzing turbulence time series that do not always generate a zero integral scale and, as a result, yield autocovariances whose time evolutions are compatible with the Navier-Stokes equation. C1 CHIRES Inc, San Antonio, TX 78220 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Trevino, G (reprint author), CHIRES Inc, POB 201481, San Antonio, TX 78220 USA. EM trevinochires@cs.com NR 22 TC 9 Z9 9 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD SEP PY 2006 VL 120 IS 3 BP 497 EP 508 DI 10.1007/s10546-006-9060-x PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 082BP UT WOS:000240361800007 ER PT J AU Kuwa, T Jordan, BS Cancio, LC AF Kuwa, Toshiyuki Jordan, Bryan S. Cancio, Leopoldo C. TI Use of power Doppler ultrasound to monitor renal perfusion during burn shock SO BURNS LA English DT Article DE ultrasonography; Doppler; burns; renal circulation; shock; regional blood flow ID ABDOMINAL COMPARTMENT SYNDROME; RESISTIVE INDEX; BLOOD-FLOW; ANIMAL-MODEL; SONOGRAPHY; FAILURE; ULTRASONOGRAPHY; KIDNEYS; REDISTRIBUTION; RESUSCITATION AB Background: Renal cortical blood flow can be quantified by means of power Doppler ultrasound (PDUS) image analysis. We hypothesized that renal cortical perfusion, estimated by PDUS image intensity (PDUSII), would decrease during burn shock and improve during resuscitation in a porcine model. Methods: Eight anesthetized swine sustained a 75% scald injury. Resuscitation began 6 h postburn. Renal cortical blood flow was measured directly using fluorescent microspheres (CORFLO), and was estimated noninvasively by PDUSII. PDUSII, CORFLO, and cardiopulmonary data were recorded every 2 It. Results: PDUSII decreased significantly from preburn to postburn hour 6, and increased with resuscitation by hour 8. CORFLO correlated well with PDUS image intensity (n = 48, r(2) = 0.696) but poorly with urine output (n = 48, r(2) = 0.252). Conclusion: PDUS in this study was superior to the urine output in assessing renal cortical microvascular blood flow during shock and resuscitation, and may be useful in the care of injured patients. (C) 2006 Elsevier Ltd and ISBI. All rights reserved. C1 USA, Inst Surg Res, Lib Branch, Ft Sam Houston, TX 78234 USA. Hyogo Prefectural Nishinomiya Hosp, Trauma & Crit Care Ctr, Nishinomiya, Hyogo, Japan. RP Cancio, LC (reprint author), USA, Inst Surg Res, Lib Branch, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Lee.Cancio@amedd.army.mil NR 46 TC 8 Z9 10 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2006 VL 32 IS 6 BP 706 EP 713 DI 10.1016/j.burns.2006.01.017 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 094WZ UT WOS:000241271200008 PM 16905265 ER PT J AU Kalvass, PE Geibel, JJ AF Kalvass, Peter E. Geibel, John J. TI California recreational abalone fishery catch and effort estimates for 2002 from a combined report card and telephone survey SO CALIFORNIA FISH AND GAME LA English DT Article ID HALIOTIS-RUFESCENS; RED ABALONE AB Total catch and effort were estimated for the 2002 California recreational abalone fishery, using a combination of returned report card data complimented by a telephone survey to estimate the contribution of unreturned report cards. There were 35,146 cards purchased for fishing year 2002. Abalone catch and effort were estimated at 264,130 (95% Cl +/- 16,823) abalone and 100,473 (95% Cl +/- 6,822) picker days. Catch per unit of effort averaged 2.63 abalone per picker day and 8.54 abalone per picker year. Report cards revealed that the Fort Ross area in Sonoma County and Van Damme State Park in Mendocino County provided the most abalone for pickers in 2002. Sonoma and Mendocino counties contributed almost 25% of abalone card purchasers,with 6 northern California counties accounting for over 50% of the purchasers. Telephone survey data revealed the mean number of abalone trips in 2002 as 3.1, with the mean age of pickers as 44 years. Approximately 58% of the telephone surveyed pickers accurately recalled their number of effort days and abalone taken. On average, pickers who returned their abalone report cards picked more days and took more abalone than those who did not return their cards. C1 Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. Calif Dept Fish & Game, Belmont, CA 94002 USA. RP Kalvass, PE (reprint author), Calif Dept Fish & Game, 19160 S Harbor Dr, Ft Bragg, CA 95437 USA. NR 4 TC 6 Z9 6 U1 0 U2 3 PU CALIF FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD FAL PY 2006 VL 92 IS 4 BP 157 EP 171 PG 15 WC Fisheries; Zoology SC Fisheries; Zoology GA 104CG UT WOS:000241932900001 ER PT J AU Sunde, JS Donninger, H Wu, KM Johnson, NE Pestell, RG Rose, GS Mok, SC Brady, J Bonome, T Birrer, MJ AF Sunde, Jan S. Donninger, Howard Wu, Kongming Johnson, Nhchael E. Pestell, Richard G. Rose, G. Scott Mok, Samuel C. Brady, John Bonome, Tomas Birrer, Michael J. TI Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer SO CANCER RESEARCH LA English DT Article ID RECEPTOR-TYPE-II; TGF-BETA; MUTATION ANALYSIS; PROBABLE TARGET; CELL CARCINOMAS; SMAD PROTEINS; EVI-1; ONCOPROTEIN; MECHANISMS; BINDING AB Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers to identify signaling pathways involved in ovarian cancer. A total of seven genes involved in TGF-beta signaling were identified that had altered expression > 1.5-fold (P < 0.001) in the ovarian cancer specimens compared with normal ovarian surface epithelium. The expression of these genes was coordinately altered: genes that inhibit TGF-beta signaling (DACH1, BMP7, and EVI1) were up-regulated in advanced-stage ovarian cancers and, conversely, genes that enhance TGF-beta signaling (PCAF, TFE3, TGFBRII, and SMAD4) were down-regulated compared with the normal samples. The microarray data for DACH1 and EVI1 were validated using quantitative real-time PCR on 22 microdissected ovarian cancer specimens. The EVI1 gene locus was amplified in 43% of the tumors, and there was a significant correlation (P = 0.029) between gene copy number and EVI1 gene expression. No amplification at the DACH1 locus was found in any of the samples. DACH1 and EVI1 inhibited TGF-beta signaling in immortalized normal ovarian epithelial cells, and a dominant-negative DACH1, DACH1-Delta DS, partially restored signaling in an ovarian cancer cell line resistant to TGF-beta. These results suggest that altered expression of these genes is responsible for disrupted TGF-beta signaling in ovarian cancer and they may be useful as new and novel therapeutic targets for ovarian cancer. C1 NCI, Dept Cell & Canc Biol, Bethesda, MD 20892 USA. NCI, Cellular Oncol Lab, Virus Tumor Biol Sect, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA. Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Gynecol Oncol, Boston, MA 02115 USA. RP Birrer, MJ (reprint author), NCI, Dept Cell & Canc Biol, 37 Convent Dr,Room 1130, Bethesda, MD 20892 USA. EM birrerm@bprb.nci.nih.gov FU Intramural NIH HHS NR 50 TC 65 Z9 67 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD SEP 1 PY 2006 VL 66 IS 17 BP 8404 EP 8412 DI 10.1158/0008-5472.CAN-06-0683 PG 9 WC Oncology SC Oncology GA 081PL UT WOS:000240329400015 PM 16951150 ER PT J AU Nevin, RL Rubertone, MV AF Nevin, R. L. Rubertone, M. V. TI Numbers and frequencies of serum specimens in the department of Defense Serum Repository SO CELL PRESERVATION TECHNOLOGY LA English DT Meeting Abstract C1 USA, Med Surveillance Activ, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-344X J9 CELL PRESERV TECHNOL JI Cell Preserv. Technol. PD FAL PY 2006 VL 4 IS 3 MA 33 BP 226 EP 227 PG 2 WC Cell Biology; Medical Laboratory Technology SC Cell Biology; Medical Laboratory Technology GA 106OE UT WOS:000242109500041 ER PT J AU Mahmood, U Hanna, NM Han, SK Jung, WG Chen, ZP Jordan, B Yershov, A Walton, R Brenner, M AF Mahmood, Usama Hanna, Nevine Mikhail Han, Sugku Jung, Woong-Gyu Chen, Zhonping Jordan, Bnjan Yershov, Andrey Walton, Ronald Brenner, Matthew TI Evaluation of rabbit tracheal inflammation using optical coherence tomography SO CHEST LA English DT Article DE bioengineering; pathology; trachea; tracheal injury; tracheal surgery ID HIGH-RESOLUTION; BIOPSY AB Background: Optical coherence tomography (OCT) is an evolving technology that is capable of delivering real-time, high-resolution images of tissues. The purpose of this study was to evaluate the feasibility of using OCT for detecting airway pathology in a septic animal model. Methods: The tracheas of New Zealand white rabbits were inoculated endobronchially with various concentrations of live Streptococcus pneumoniae bacteria. After the development of pneumonia/sepsis, the animals were killed. OCT tracheal images and corresponding histologic specimens from these experimental animals were compared to control rabbit tracheas for morphologic features and quantitative tracheal mucosal thickness measurements. Results: The results revealed significant airway mucosal thickening in the experimental group that was consistent with tracheal edema. Morphologic changes, including epithelial denuding and mucosal sloughing, were evident in regions of the experimental tracheas. Conclusion: This study suggests that OCT is a potentially valuable imaging modality that is capable of evaluating superficial airway pathology with high-resolution in vivo images. Numerous applications of OCT can be envisioned in the realm of pulmonary medicine and thoracic surgery that may substantially increase the precision and accuracy of current bronchoscopic diagnostic and surgical techniques. C1 Univ Calif Irvine, Beckman Laser Inst, Med Ctr, Orange, CA 92868 USA. Univ Calif Irvine, Pulm & Crit Care Div, Med Ctr, Orange, CA 92868 USA. USA, Inst Surg Res, San Antonio, TX USA. RP Chen, ZP (reprint author), Univ Calif Irvine, Beckman Laser Inst, Med Ctr, Bldg 53,Room 119, Orange, CA 92868 USA. EM zchen@laser.bli.uci.edu FU NCRR NIH HHS [RR-01192]; NIBIB NIH HHS [EB-00293]; PHS HHS [NCI-91717] NR 16 TC 11 Z9 14 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2006 VL 130 IS 3 BP 863 EP 868 DI 10.1378/chest.130.3.863 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 085EG UT WOS:000240585600038 PM 16963687 ER PT J AU Mita, AC Hammond, LA Bonate, PL Weiss, G McCreery, H Syed, S Garrison, M Chu, QSC DeBono, JS Jones, CB Weitman, S Rowinsky, EK AF Mita, Alain C. Hammond, Lisa A. Bonate, Peter L. Weiss, Geoffrey McCreery, Heather Syed, Samira Garrison, Mitchell Chu, Quincy S. C. DeBono, Johann S. Jones, Christopher B. Weitman, Steve Rowinsky, Eric K. TI Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors SO CLINICAL CANCER RESEARCH LA English DT Article ID METASTATIC BREAST; CANCER; MICROTUBULE; PACLITAXEL; LU-103793; INFUSION AB Purpose: To determine the safety, tolerability, and pharmacokinetics and to seek preliminary evidence of anticancer activity of tasidotin (ILX651), a novel dolastatin analogue, when administered as a 30-minute i.v. infusion weekly for 3 weeks every 4 weeks. Experimental Design: Thirty patients with advanced solid malignancies were treated with 82 courses at six dose levels ranging from 7.8 to 62.2 mg/m(2) weekly, initially according to an accelerated dose-escalation scheme, which evolved into a Fibonacci scheme as a relevant degree of toxicity was observed. Plasma and urine were sampled to characterize the pharmacokinetic behavior of tasidotin. Results: A high incidence of neutropenia complicated by fever (one patient), or precluding treatment on day 15 (three patients), was the principal toxicity of tasidotin, at doses above 2 46.8 mg/m(2). At all dose levels, nonhematologic toxicities were generally mild to moderate and manageable. Grade 3 toxicities included diarrhea and vomiting (one patient each). Drug-induced neurosensory symptoms were mild and there was no evidence of cardiovascular toxicity, which has been previously associated with other dolastatins. Tasidtin pharmacokinetics were mildly nonlinear, whereas metabolite kinetics were linear. A patient with non-small cell lung carcinoma experienced a minor response, and a patient with hepatocellular carcinoma had stable disease lasting 11 months. Conclusions: The recommended dose for phase II studies of tasidotin administered on this 2 schedule is 46.8 mg/m(2). The mild myelosuppression and manageable nonhematologic toxicities at the recommended dose, the evidence of antitumor activity, and the unique mechanistic aspects of tasidotin warrant further disease-directed evaluations on this and alternative schedules. C1 Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. Genzyme Corp, San Antonio, TX USA. RP Mita, AC (reprint author), Canc Therapy & Res Ctr S Texas, Inst Drug Dev, 7979 Wurzbach Rd,4th Floor Zeller Bldg, San Antonio, TX 78229 USA. EM amita@idd.org FU Medical Research Council [G0501019] NR 29 TC 37 Z9 41 U1 3 U2 5 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD SEP 1 PY 2006 VL 12 IS 17 BP 5207 EP 5215 DI 10.1158/1078-0432.CCR-06-0179 PG 9 WC Oncology SC Oncology GA 082MX UT WOS:000240392000030 PM 16951240 ER PT J AU Stone, MKE Bauch, TD Rubal, BJ AF Stone, Maj Kenneth E. Bauch, Terry D. Rubal, Bernard J. TI Respiratory changes in the pulse-oximetry waveform associated with pericardial tamponade SO CLINICAL CARDIOLOGY LA English DT Article DE pulse oximetry; cardiac tamponade; pericardial effusion ID PARADOXUS; DISEASE; HEART AB Background: Timely identification of hemodynamic compromise in patients with acute pericardial effusion and tamponade is critical in patient management. Respiratory variability in pulse-oximetry waveforms has been correlated with pulsus paradoxus. but has not been reported with cardiac tamponade in adult patients. Hypothesis: This study describes changes in respiratory variability in pulse-oximetry waveform pre and post pericardiocentesis in patients with hemodynamically significant pericardial effusions. Methods: A single-center, catheterization laboratory hemodynamic database was reviewed for all patients who underwent pericardiocentesis for clinically suspected tamponade and had continuous digital pulse-oximetry, electrocardiographic, and respiration waveforms recorded during the procedure. Phasic respiratory changes in pulse-oximetry waveform amplitude (maxima-minima) were expressed as an expiratory/inspiratory ratio and compared pre and post pericardiocentesis. Results: The study population consisted of 12 patients (6 men:6 women, age 60 10 years) with pericardial effusion documented by echocardiography on the day of pericardiocentesis. Phasic respiratory variability in the pulse-oximetry waveform was evident in all patients prior to aspiration (respiratory ratio = 1.9 +/- 0.5). Following pericardiocentesis (aspirated volume: 650 300 ml), the respiratory ratio decreased in all patients (1.2 +/- 0.1, p = 0.001). Receiver operator characteristic curve analysis suggests that pulse-oximetry respiratory ratios >= 1.5 should raise suspicion of hemodynamic compromise in high-risk populations. Conclusions: Pulse-oximetry is a commonly used tool for monitoring critically ill patients. The present study suggests that increased respiratory variability in the pulse-oximetry waveform should raise suspicion for hemodynamic compromise in patients at risk for pericardial effusion. C1 Brooke Army Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. RP Stone, MKE (reprint author), Brooke Army Med Ctr, Serv Cardiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kenneth.stone2@cen.amedd.army.mil NR 13 TC 3 Z9 3 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 USA SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD SEP PY 2006 VL 29 IS 9 BP 411 EP 414 DI 10.1002/clc.4960290908 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 080TA UT WOS:000240270000007 PM 17007173 ER PT J AU Rakowski, DA Caillard, S Agodoa, LY Abbott, KC AF Rakowski, Daniel A. Caillard, Sophie Agodoa, Lawrence Y. Abbott, Kevin C. TI Dementia as a predictor of mortality in dialysis patients SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID STAGE RENAL-DISEASE; CARDIOVASCULAR HEALTH; UNITED-STATES; THERAPY; DEATH; RISK; WITHDRAWAL; INITIATION; DECISIONS; SURVIVAL AB The life expectancy of patients who have dementia and are initiated on dialysis in the United States has not been described in the medical literature. A retrospective cohort study was conducted of 272,024 Medicare/Medicaid primary patients in the US Renal Data System who were started on ESRD therapy between April 1, 1995, and December 31, 1999, and followed through December 31, 2001. Cox regression was used to calculate adjusted hazard ratios for risk for death after initiation of dialysis for patients whose dementia was diagnosed before the initiation of dialysis as shown by Medicare claims. The average time to death for patients with dementia was 1.09 versus 2.7 yr (P < 0.001) with an adjusted hazard ratio of 1.87 (95% confidence interval 1.77 to 1.98). The 2-yr survival for patients with dementia was 24 versus 66% for patients without dementia (P < 0.001 via log rank test). Dementia that is diagnosed before initiation on dialysis is an independent risk factor for subsequent death. Such patients should be considered for time-limited trials of dialysis and careful discussion in choosing whether to pursue initiation of dialysis or palliative care. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NIDDK, NIH, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@na.amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 20 TC 49 Z9 50 U1 0 U2 1 PU AMERICAN SOCIETY NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD SEP PY 2006 VL 1 IS 5 BP 1000 EP 1005 DI 10.2215/CJN.00470705 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 107LL UT WOS:000242173000017 PM 17699319 ER PT J AU Cooper, PB Auerbach, A Aguilera, NS Adair, C Moores, L Geyer, D Rushing, EJ AF Cooper, P. B. Auerbach, A. Aguilera, N. S. Adair, C. Moores, L. Geyer, D. Rushing, E. J. TI Rare primary CNS anaplastic large cell lymphoma in an immunocompetent adult: a clinical-pathologic case report and review of the literature SO CLINICAL NEUROPATHOLOGY LA English DT Review DE brain; CD30; immunocompetent; lymphoma; T-cell ID NERVOUS-SYSTEM LYMPHOMA; ORIGIN AB Objective and importance: Isolated anaplastic large cell lymphoma (ALCL) presenting in the primary central nervous system is distinctly uncommon. The authors describe a case that clinically and radiographically simulated a primary glial neoplasm. Clinical presentation: A 39-year-old immunocompetent male presented with seizures and a rapidly enlarging right occipital/parietal lesion. Magnetic resonance images demonstrated a right occipitoparietal lesion, hypodense on T1WI, with patchy contrast enhancement with gadolinium and significant white matter edema pattern on T2WI along with mass effect and midline shift. Intervention: The patient underwent a frameless stereotactic assisted needle biopsy. There appeared to be a clear demarcation between white matter and tumor with no obvious necrosis. Biopsy showed a proliferation of single cells and poorly cohesive groups of cells with large, pleomorphic nuclei, many containing prominent nucleoli, and a moderate amount of cytoplasm. Immunohistochemical staining revealed CD-30 and ALK-positivity typical of ALCL, a rare form of T-cell lymphoma. An extensive workup revealed neither systemic disease nor evidence of immunocompromise. Conclusion: Reported in less than 20 patients, primary ALCL in an immunocompetent patient is rarely found intracranially; however, its ability to mimic glial neoplasms as well as other pathologies underlines its importance. C1 Armed Forces Inst Pathol, Dept Neuropathol & Ophthalm Pathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Dept Hematopathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Natl Capitol Consortium, Dept Neurosurg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Natl Capitol Consortium, Dept Pathol, Washington, DC 20307 USA. RP Rushing, EJ (reprint author), Armed Forces Inst Pathol, Dept Neuropathol & Ophthalm Pathol, Washington, DC 20306 USA. EM rushinge@afip.osd.mil NR 11 TC 6 Z9 6 U1 0 U2 1 PU DUSTRI-VERLAG DR KARL FEISTLE PI DEISENHOFEN-MUENCHEN PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY SN 0722-5091 J9 CLIN NEUROPATHOL JI Clin. Neuropathol. PD SEP-OCT PY 2006 VL 25 IS 5 BP 232 EP 236 PG 5 WC Clinical Neurology; Pathology SC Neurosciences & Neurology; Pathology GA 087FL UT WOS:000240728200005 PM 17007446 ER PT J AU Jackson, WL Shorr, AF AF Jackson, William L., Jr. Shorr, Andrew F. TI Blood transfusion and nosocomial infection: Another brick in the wall SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE leukoreduction; nosocomial infection; packed red blood cells; transfusion ID CRITICALLY-ILL PATIENTS; RESPIRATORY-DISTRESS-SYNDROME; CELL TRANSFUSION; UNIVERSAL LEUKOREDUCTION; CLINICAL-OUTCOMES; STORAGE TIME; RED-CELLS; SURGERY; SEPSIS; ANEMIA C1 Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. Washington Hosp Ctr, Pulm & Crit Care Med Sect, Washington, DC 20010 USA. RP Jackson, WL (reprint author), Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. NR 28 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD SEP PY 2006 VL 34 IS 9 BP 2488 EP 2489 DI 10.1097/01.CCM.0000235677.30848.42 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 077EK UT WOS:000240010400032 PM 16921320 ER PT J AU Blasko, DJ AF Blasko, Dennis J. TI Rumsfeld's take on the Chinese military: A dissenting view SO CURRENT HISTORY LA English DT Article C1 USA, Washington, DC 20310 USA. RP Blasko, DJ (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 USA SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD SEP PY 2006 VL 105 IS 692 BP 263 EP 269 PG 7 WC International Relations; Political Science SC International Relations; Government & Law GA 078OT UT WOS:000240113800004 ER PT J AU Petersen, MC Kedia, S Davis, P Newman, L Temple, C AF Petersen, Mario C. Kedia, Satish Davis, Pam Newman, Lisa Temple, Carrie TI Eating and feeding are not the same: caregivers perceptions of gastrostomy feeding for children with cerebral palsy SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY LA English DT Article ID DISABLED-CHILDREN; LIFE-EXPECTANCY; DISABILITIES; PREVALENCE; NUTRITION; IMPACT AB Using a semi-structured questionnaire, this descriptive study examined perceptions of feeding and adherence to feeding recommendations for caregivers (26 females; mean age 32y 7mo [SD 9.4y], range 20-59y) of children with cerebral palsy (CP) and a gastrostomy tube (GT). Children in the study (15 females, 11 males; mean age 4y 8mo [SD 3y 11mo], range 8mo-16y) had had a GT in place for at least 1 month and been assessed at Level H (n=2), Level M (n=2), Level IV (n=5), and Level V (n=17) of the Gross Motor Function Classification System. A negative response was reported by 18 caregivers when the GT was recommended; however, 21 caregivers reported improvement in the children following placement. All children received formula through the GT that was adequate for complete nutrition, yet 14 caregivers gave other foods through the GT (e.g. juice, cereal, soup, or table food). Of the 17 children receiving oral feedings, meals were an unpleasant experience for over half. Of the remaining nine children, in spite of a strict nil by mouth recommendation by physicians, five continued to receive some oral feedings. Generally, caregivers perceived GT feeding as 'unnatural'. Understanding these perceptions will help clinicians to develop effective, family-centered, patient-appropriate intervention and adherence strategies for GT-fed children with CP. C1 Univ Memphis, Le Bonheur Childrens Med Ctr, Memphis, TN 38152 USA. Univ Memphis, Boling Ctr Dev Disabil, Memphis, TN 38152 USA. Univ Memphis, Dept Anthropol, Memphis, TN 38152 USA. Methodist Extended Care Hosp, Memphis, TN USA. Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Petersen, MC (reprint author), Oregon Hlth Sci Univ, Child Dev & Rehabil Ctr, Rehabil Serv, 901 18th Ave, Eugene, OR 97403 USA. EM mcp@uoregon.edu NR 25 TC 26 Z9 29 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0012-1622 J9 DEV MED CHILD NEUROL JI Dev. Med. Child Neurol. PD SEP PY 2006 VL 48 IS 9 BP 713 EP 717 DI 10.1017/S0012162206001538 PG 5 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 079KA UT WOS:000240173500004 PM 16904015 ER PT J AU Balas, B Belfort, R Gastaldelli, A Harrison, S Finch, J Darland, C Schenker, S Cusi, K AF Balas, B. Belfort, R. Gastaldelli, A. Harrison, S. Finch, J. Darland, C. Schenker, S. Cusi, K. TI Metabolic and anti-inflammatory effects of pioglitazone (PIO) lead to histological improvement in patients with non-alcoholic steatohepatitis (NASH) SO DIABETOLOGIA LA English DT Meeting Abstract CT 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) CY SEP 14-17, 2006 CL Copenhagen, DENMARK SP European Assoc Study Diabet C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD SEP PY 2006 VL 49 SU 1 MA 0255 BP 161 EP 161 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 085TB UT WOS:000240626200255 ER PT J AU Gastaldelli, A Hardies, J Belfort, R Harrison, S Balas, B Brown, K Schenker, S Cusi, K AF Gastaldelli, A. Hardies, J. Belfort, R. Harrison, S. Balas, B. Brown, K. Schenker, S. Cusi, K. TI Metabolic and histologic improvement by pioglitazone treatment in NASH increases plasma adiponectin levels and reduces visceral and liver fat in patients with NASH SO DIABETOLOGIA LA English DT Meeting Abstract CT 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) CY SEP 14-17, 2006 CL Copenhagen, DENMARK SP European Assoc Study Diabet C1 Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD SEP PY 2006 VL 49 SU 1 MA 0256 BP 161 EP 162 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 085TB UT WOS:000240626200256 ER PT J AU Zhang, SS AF Zhang, Sheng Shui TI An unique lithium salt for the improved electrolyte of Li-ion battery SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE lithium oxalyldifluoroborate; lithium bis(oxalato)borate; LiBF(4); electrolyte; Li-ion battery ID LOW-TEMPERATURE PERFORMANCE; LIBOB-BASED ELECTROLYTES; INTERFACE; CHEMISTRY; LIBF4; EC AB Lithium oxalyldifluoroborate (LiODFB) is first reported as the salt for improved electrolyte of Li-ion battery. This salt was found to have the combined advantages of lithium bis(oxalato)borate (LiBOB) and LiBF(4) due to its chemical structure comprising the half molecular moieties of LiBOB and LiBF4. Compared with LiBOB, the salt is more soluble in linear carbonates and the resulting solution is less viscous, which results in the battery better low temperature and high rate performance. Unlike LiBF4, the salt is highly capable of stabilizing solid electrolyte interface (SEI) on the surface of graphite anode, which enables Li-ion cell to be operated stably at high temperature. For example, a graphite/LiNi(1-x-y)M(x)N(y)O(2) (M and N are metal atoms) Li-ion cell suffered only about 10% capacity loss after 200 cycles at 60 degrees C. On the other hand, graphite can be cycled reversibly with LiODFB even in a solution containing high concentration (50 wt%) of propylene carbonate (PC), which makes it possible to formulate the low freezing temperature electrolyte by using PC as the co-solvent. Other merits of the LiODFB-based electrolytes include (1) the ability to support metallic lithium cycling reversibly on the surface of copper anode current collector, (2) the ability to passivate aluminum cathode current collector at high potentials, (3) the ability to participate in formation of the SEI and support Li-ion battery operating stably at high temperatures, and (4) the ability to increase battery safety protection and overcharge tolerance. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD, SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD, SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 12 TC 166 Z9 185 U1 9 U2 115 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD SEP PY 2006 VL 8 IS 9 BP 1423 EP 1428 DI 10.1016/j.elecom.2006.06.016 PG 6 WC Electrochemistry SC Electrochemistry GA 088FE UT WOS:000240796300004 ER PT J AU Kinlaw, WB Quinn, JL Wells, WA Roser-Jones, C Moncur, JT AF Kinlaw, William B. Quinn, Jennifer L. Wells, Wendy A. Roser-Jones, Christopher Moncur, Joel T. TI Minireview: Spot 14: A marker of aggressive breast cancer and a potential therapeutic target SO ENDOCRINOLOGY LA English DT Review ID FATTY-ACID SYNTHASE; LIPOGENIC GENE-EXPRESSION; HER2/NEU ERBB-2 ONCOGENE; LIPOPROTEIN-LIPASE; THYROID-HORMONE; MAMMARY-GLAND; CELL-DEATH; CYCLIN D1; PRETRANSLATIONAL LEVEL; HEPATIC ZONATION AB Spot 14 (S14) is a nuclear protein that communicates the status of dietary fuels and fuel-related hormones to genes required for long-chain fatty acid synthesis. In mammary gland, S14 is important for both epithelial proliferation and milk fat production. The S14 gene is amplified in some breast cancers and is strongly expressed in most. High expression of S14 in primary invasive breast cancer is conspicuously predictive of recurrence. S14 mediates the induction of lipogenesis by progestin in breast cancer cells and accelerates their growth. Conversely, S14 knockdown impairs de novo lipid synthesis and causes apoptosis. We found that breast cancer cells do not express lipoprotein lipase (LPL) and hypothesize that they do not have access to circulating lipids unless the local environment supplies it. This may explain why primary breast cancers with low S14 do not survive transit from the LPL-rich mammary fat pad to areas devoid of LPL, such as lymph nodes, and thus do not appear as distant metastases. Thus, S14 is a marker for aggressive breast cancer and a potential target as well. Future effort will center on validation of S14 as a therapeutic target and producing antagonists of its action. C1 Dartmouth Med Sch, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA. Dartmouth Med Sch, Dept Med, Lebanon, NH 03756 USA. Dartmouth Med Sch, Dept Pathol, Lebanon, NH 03756 USA. Walter Reed Army Med Ctr, Dept Pathol, Silver Spring, MD 20910 USA. RP Kinlaw, WB (reprint author), Dartmouth Med Sch, Norris Cotton Canc Ctr, 606 Rubin Bldg,1 Med Ctr Dr, Lebanon, NH 03756 USA. EM william.kinlaw@hitchcock.org FU NIDDK NIH HHS [R01 DK 058961] NR 58 TC 31 Z9 34 U1 2 U2 5 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD SEP PY 2006 VL 147 IS 9 BP 4048 EP 4055 DI 10.1210/en.2006-0463 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 074CM UT WOS:000239790100010 PM 16809441 ER PT J AU Kosaisavee, V Suwanarusk, R Nosten, F Kyle, DE Barrends, M Jones, J Price, R Russell, B Lek-Uthai, U AF Kosaisavee, Varakorn Suwanarusk, Rossarin Nosten, Francois Kyle, Dennis E. Barrends, Marion Jones, James Price, Ric Russell, Bruce Lek-Uthai, Usa TI Plasmodium vivax: Isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE Plasmodium vivax; chloroquine; antimalarial sensitivity; in vitro; isotopic; PicoGreen; microscopic; cryopreservation ID QUANTITATIVE ASSESSMENT; DRUG-SENSITIVITY; FALCIPARUM; BLOOD; RESISTANCE; INVITRO; MALARIA AB In vitro susceptibility tests provide information on the intrinsic response of Plasmodium vivax to antimalarials, free from confounding factors such as host immunity or relapse. This study examined the utility of radioisotope and PicoGreen assays as alternatives to the traditional microscopic examination for assessing response of P. vivax to antimalarial drugs. There was no significant difference in the mean chloroquine IC50 of P. vivax (n = 40) as determined by the microscopic (33.4 ng/ml), isotopic (33.6 ng/ml), and PicoGreen (39.1 ng/ml) assays, respectively (F= 0.239, df = 2, 51, and p = 0.788). However measurement of IC(50)s by the microscopic method was slightly more successful in producing valid assays (57%), compared to the isotopic (32.5%) and PicoGreen (45.5%) methods. In a paired comparison of 20 fresh and cryopreserved isolates as examined by the microscopic method, there were no significant differences between the mean IC50 responses (T= 1.58, df = 15, and p = 0.34). Detailed methodologies for the short time culture of field and cryopreserved P. vivax are described. Although the microscopic in vitro assay provides a useful method for characterizing the drug susceptibility phenotype of P. vivax isolates, its utility is limited by a laborious methodology and need for highly skilled microscopists. Future efforts should focus on further development of high throughput assays such as the PicoGreen assay as described in this study. (c) 2006 Elsevier Inc. All rights reserved. C1 Menzies Sch Hlth Res, Int Hlth Program, Div Infect Dis, Darwin, NT, Australia. Charles Darwin Univ, Darwin, NT, Australia. USAMC, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. Mahidol Univ, Fac Publ Hlth, Bangkok 10700, Thailand. Shoklo Malaria Res Unit, Mae Sot, Thailand. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Russell, B (reprint author), Menzies Sch Hlth Res, Int Hlth Program, Div Infect Dis, Darwin, NT, Australia. EM bruce.russell@cdu.edu.au RI Lek-Uthai, Usa/B-4205-2008; Russell, Bruce/A-9240-2011; Suwanarusk, Rossarin/E-2115-2013; OI Russell, Bruce/0000-0003-2333-4348; Suwanarusk, Rossarin/0000-0002-7310-245X; Price, Richard/0000-0003-2000-2874; Nosten, Francois/0000-0002-7951-0745 NR 12 TC 27 Z9 30 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD SEP PY 2006 VL 114 IS 1 BP 34 EP 39 DI 10.1016/j.exppara.2006.02.006 PG 6 WC Parasitology SC Parasitology GA 082GF UT WOS:000240374000005 PM 16545375 ER PT J AU Frattarelli, JL AF Frattarelli, John L. TI A prospective analysis of the changes in ovarian morphology during hormonal pituitary suppression before in vitro fertilization SO FERTILITY AND STERILITY LA English DT Article DE ovarian morphology; ovarian volume; basal antral follicles; IVF; ovulation induction; infertility; transvaginal ultrasound; oral contraceptives; GnRH-a ID ANTRAL FOLLICLE COUNT; REPRODUCTIVE TECHNOLOGY CYCLES; PROGNOSTIC ASSESSMENT; VOLUME MEASUREMENTS; DOWN-REGULATION; BASAL FSH; WOMEN; RESERVE; NUMBER; AGE AB Objective: To Assess the change in ovarian morphology at three specific times integral to an IVF cycle and to evaluate the factors associated with change in ovarian morphology after pituitary desensitization. Design: Prospective cohort analysis. Setting: Academic TVF centre. Patient(s): Infertile patients undergoiung 85 IVF cycles. Intervention(s): Eighty-five patients had transvaginal ultrasound to assess ovarian morphology on unstimulated menstrual day 3, 21 days after starting oral contraceptives (OCs), and 14 days after starting GnRH agonist (GnRH-a). Main Outcome Measure(s): Ovarian Morphology. Result(s): Compared with the basal total ovarian volume, ovarian volume was significantly decreased after 21 days of OCs and after 14 days of GnRH-a. A significant decrease was noted in the total number of antral follicles from the basal state to after 21 days of OCs and after 14 days of GnRH-a treatment. There was no significant effect on pregnancy outcome rates. Univariate analysis showed a significant correlation between ovarian morphology and IVF stimulation parameters. Conclusion(s): Hormonal suppression significantly alters ovarian morphology. If the use of ovarian morphology is to be used to counsel patients and predict IVF success as suggested by some studies, it should be standardized for the day the ovarian morphology is evaluated. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Frattarelli, JL (reprint author), Reprod Med Associates New Jersey, 100 Franklin Sq Dr,Suite 200, Somerset, NJ 08873 USA. EM ifrattarelli@rmanj.com NR 29 TC 3 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2006 VL 86 IS 3 BP 577 EP 582 DI 10.1016/j.fertnstert.2006.01.037 PG 6 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 091AN UT WOS:000240998000016 PM 16828478 ER PT J AU Parker, JD Leondires, M Sinaii, N Premkumar, A Nieman, LK Stratton, P AF Parker, Jason D. Leondires, Mark Sinaii, Ninet Premkumar, Ahalya Nieman, Lynnette K. Stratton, Pamela TI Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis SO FERTILITY AND STERILITY LA English DT Article DE adenomyosis; endometriosis; chronic pelvic pain; magnetic resonance imaging; junctional zone thickness; visual analog scale ID UTERINE JUNCTIONAL ZONE; CHRONIC PELVIC PAIN; TRANSVAGINAL SONOGRAPHY; PRIMARY-CARE; UTERUS; PREVALENCE; DIAGNOSIS; US; DIFFERENTIATION; ULTRASONOGRAPHY AB Objective: To evaluate whether persistence of pelvic pain after excision of endometriosis was associated with adenomyosis as defined by a thickened uterine junctional zone (JZ) on magnetic resonance (MR) imaging. Design: Prospective clinical trial. Setting: Government research hospital. Patients(s): Fifty-three women with chronic pelvic pain. Intervention(s): Preoperative MR imaging to measure uterine JZ thickness, surgical excision, and pathological diagnosis of endometriosis. Those with biopsy-proven endometriosis were randomised to raloxifene or placebo. Visual analog scale (VAS) was used to rate dysmenorrhea and nonmenstrual pain severity before and 3 months later. Main Outcome Measure(s): Comparison of JZ thickness and pain severity before and 3 months after surgery in women with endometriosis controlling for medical treatment. Results(s): Forty of the 53 patients had biopsy proven endometriosis, and 6 of these 40 women with endometriosis had a thickened JZ. Overall, dysmenorrhea at 3 months was positively correlated with preoperative JZ thickness (r=0.47, P=.01). Dysmenorrhea pain severity showed no significant decrease in those patients whose JZ measured >= 11 mm compared with those with JZ < 8mm (P <.0001; VAS decreased 4.3 +/- 0.6), or >= 8 and < 11 mm (P <.02 VAS decreased 4.8 +/- 1.3). Nonmenstrual pain severity was correlated with JZ thickness (r=0.51, P=.004) at 3 months with a significant decrease in nonmenstrual pain only in woman with a JZ < 8 mm (VAS decreased 4.0 +/- 0.7, P <.0001). The associated between dysmenorrhea and nonmenstual pain reduction and thinner JZ remained after controlling for medical treatment. Conclusion(s): Following surgical excision of endometriosis, chronic pelvic pain was significantly more likely to persist with JZ thickness > 11mm on preoperative MR imaging. This suggests that mymometrial JZ abnormalities or adenomyosis may contribute to chronic pelvic pain in women with endometriosis. C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. Natl Naval Med Ctr, Walter Reed Army Med Ctr, NIH, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Reprod Med Assoc Connecticut, Norwalk, CT USA. NIH, Ctr Clin, Dept Radiol, Bethpage, MD USA. RP Stratton, P (reprint author), NICHD, RBMB, NIH, 10 Ctr Dr,Bldg 10 CRC,1 E-3140, Bethesda, MD 20892 USA. EM ps79c@nih.gov FU Intramural NIH HHS NR 36 TC 36 Z9 36 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2006 VL 86 IS 3 BP 711 EP 715 DI 10.1016/j.fertnstert.2006.01.030 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 091AN UT WOS:000240998000037 PM 16782099 ER EF