FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bird, DN Sato, AK Pole, GL Claybaugh, JR AF Bird, DN Sato, AK Pole, GL Claybaugh, JR TI Effects of prenatal ethanol and choline on urinary vasopressin excretion in the rat SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Tripler Army Med Ctr, Tripler, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1444 EP A1444 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205365 ER PT J AU Blaha, MD Leon, LR AF Blaha, MD Leon, LR TI The liver is not an important source for circulating cytokines in beat strained mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1269 EP A1269 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326204065 ER PT J AU Bowman, PD Sondeen, JL Bynum, JA Vaughan, GM Wade, CE Dubick, MA AF Bowman, PD Sondeen, JL Bynum, JA Vaughan, GM Wade, CE Dubick, MA TI Temporal gene expression analysis of rat jejunum following 40% hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 US Army Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1385 EP A1385 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205095 ER PT J AU Campbell, KC Maliborski, S Jett, M Mendis, C AF Campbell, KC Maliborski, S Jett, M Mendis, C TI Gene expression patterns and pathway functions of SEB induced human PBMC SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Wisconsin, Platteville, WI 53818 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A934 EP A934 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201033 ER PT J AU Chowdhury, B Krishnan, S Tsokos, CG Robertson, J Fisher, CU Nambiar, MP Tsokos, GC AF Chowdhury, B Krishnan, S Tsokos, CG Robertson, J Fisher, CU Nambiar, MP Tsokos, GC TI Stability and translation of T cell receptor zeta chain are regulated by the splice deleted 562-bp 3 ' UTR in systemic lupus erythematosus patients SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A932 EP A932 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201024 ER PT J AU Collins, LL Vorojeikina, D Minsavage, GD Gasiewicz, TA AF Collins, LL Vorojeikina, D Minsavage, GD Gasiewicz, TA TI Protein kinase C phosphorylates mouse aryl hydrocarbon receptor (AhR) at serine 11 and threonine 21 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Rochester, Sch Med & Dent, Rochester, NY 14642 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A973 EP A973 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201223 ER PT J AU Convertino, VA Rickards, CA Ryan, KL Cooke, WH Lurie, KG AF Convertino, VA Rickards, CA Ryan, KL Cooke, WH Lurie, KG TI Effects of inspiratory impedance on hemodynamic responses and tolerance to progressive reduction in central blood volume: implications for treatment of patients with severe hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Annual Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Expt Therapeut C1 US Army Inst Surg Res, Houston, TX 78234 USA. Univ Texas San Antonio, San Antonio, TX 78249 USA. Adv Circulatory Syst, Eden Prairie, MN 55344 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1383 EP A1383 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205085 ER PT J AU Cymerman, A Muza, SR Fulco, CS Friedlander, AL Elliott, LD Zupan, MF AF Cymerman, A Muza, SR Fulco, CS Friedlander, AL Elliott, LD Zupan, MF TI Oculometrics as a measure of altitude acclimatization of moderate-altitude residents compared to sea-level residents SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. Palo Alto VA Hlth Care Syst, GRECC, Palo Alto, CA 94304 USA. USAF Acad, Athlet Dept, Colorado Springs, CO 80840 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1431 EP A1431 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205302 ER PT J AU Debus, SJ Spriggs, DL Likens, EN Chang, FCT AF Debus, SJ Spriggs, DL Likens, EN Chang, FCT TI A comparative survey of carbamate-oxime efficacy against the lethal effects of Soman (GD) in guinea pigs. SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1134 EP A1134 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326202430 ER PT J AU Dubick, MA Cameron, DG Kauvar, DS Walters, TJ AF Dubick, MA Cameron, DG Kauvar, DS Walters, TJ TI Antioxidant status in skeletal muscle from rats subjected to hemorrhage, tourniquet application and fluid resuscitation. SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 US Army Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1381 EP A1381 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205077 ER PT J AU DuBose, DA Morehouse, DH Rufolo, DM Leon, LR AF DuBose, DA Morehouse, DH Rufolo, DM Leon, LR TI Hypothermia (HYP) induces tachycardia, not bradycardia in free-ranging (FR) rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1450 EP A1450 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205392 ER PT J AU Feijoo, AA Hashiro, GM Uyehara, CFT AF Feijoo, AA Hashiro, GM Uyehara, CFT TI Vasopressin V2 receptor expression during different phases of the estrous cycle in Sprague Dawley rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Maryland, Baltimore, MD 21250 USA. Tripler Army Med Ctr, Tripler, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1445 EP A1445 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205368 ER PT J AU Gao, XG Ray, R Ray, P AF Gao, XG Ray, R Ray, P TI Inhibition of sulfur mustard induced cytotoxicity and inflammation by roxithromycin in human airway epithelial cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1094 EP A1094 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326202247 ER PT J AU Gonzales, RF Peyrefitte, CN Mani, S Coleman, GD Tolou, H Jett, M AF Gonzales, RF Peyrefitte, CN Mani, S Coleman, GD Tolou, H Jett, M TI Coagulation changes in a piglet model of SEB intoxication SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Serv Sante Armees, Inst Med Trop, F-13998 Marseille, France. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1381 EP A1381 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205075 ER PT J AU Ha, JJ Garcia, GE Askins, LY Moorad-Doctor, D Ratcliffe, RH Singh, H Jewell, ML Calinski, DM Carra, JH Gordon, RK AF Ha, JJ Garcia, GE Askins, LY Moorad-Doctor, D Ratcliffe, RH Singh, H Jewell, ML Calinski, DM Carra, JH Gordon, RK TI Botulinum toxin B therapeutics SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA, USAMRIID, MCMR, Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RI Ratcliffe, Ruthie/B-6815-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A898 EP A898 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326200378 ER PT J AU Hammamieh, R Bi, S Neill, R Jett, M AF Hammamieh, R Bi, S Neill, R Jett, M TI SEB-induced host gene expression in peripheral blood mononuclear cells in vitro and in vivo in piglets SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1298 EP A1298 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326204192 ER PT J AU Hiner, MC Lehr, R Jett, M Chakraborty, N AF Hiner, MC Lehr, R Jett, M Chakraborty, N TI Genetic comparison of SEB to LPS for rapid diagnostics SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Univ Wisconsin, Platteville, WI 53818 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A911 EP A911 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326200442 ER PT J AU Ishida, H Ray, R Ray, P AF Ishida, H Ray, R Ray, P TI Role of nitric oxide in wound healing SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USAMRICD, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1072 EP A1072 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326202148 ER PT J AU Jennings, AM Merritt, E Lee, S Walters, T Farrar, RP AF Jennings, AM Merritt, E Lee, S Walters, T Farrar, RP TI Attenuated recovery from ischemia/reperfusion in 4-hour tourniquet application SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Texas, Austin, TX 78712 USA. Texas A&M, Laredo, TX 78041 USA. USA, Inst Surg Res, Soft Tissue Injury Lab, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1158 EP A1158 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326203051 ER PT J AU Kiang, JG Peckham, RM Duke, LE Chaudry, IH Tsokos, GC AF Kiang, JG Peckham, RM Duke, LE Chaudry, IH Tsokos, GC TI Androstenediol (AED) inhibits caspase-3 increase in rat liver after trauma-hemorrhage (T-H) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Univ Alabama, Birmingham, AL 35294 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1462 EP A1462 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205444 ER PT J AU Klemcke, HG Baer, D Cox, A Cortez, D Garrete, MR Joe, B Ryan, KL AF Klemcke, HG Baer, D Cox, A Cortez, D Garrete, MR Joe, B Ryan, KL TI Differences in survival time to controlled hemorrhage among inbred rat strains. SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 US Army Inst Surg Res, Sam Houston, TX 78234 USA. Med Univ Ohio, Toledo, OH 43614 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1382 EP A1382 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205082 ER PT J AU Maliborski, SL Mendis, C Jett, M AF Maliborski, SL Mendis, C Jett, M TI Gene expression pattern and pathway functions of SEB and SEA induced human PBMC SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Wisconsin Platteville, Platteville, WI 53818 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A912 EP A912 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326200444 ER PT J AU Mayda, ME Zapata, JC Hammamieh, R Das, R Djavani, M Lukashevich, I Moshkoff, D Salvato, M Jett, M AF Mayda, ME Zapata, JC Hammamieh, R Das, R Djavani, M Lukashevich, I Moshkoff, D Salvato, M Jett, M TI Gene expression patterns: Human blood cells exposed to common flu-like viruses SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1103 EP A1103 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326202289 ER PT J AU McClung, JP Montain, SJ Cheuvront, SN He, JR Hasday, JD Singh, IS AF McClung, JP Montain, SJ Cheuvront, SN He, JR Hasday, JD Singh, IS TI Differential responsiveness to heat shock protein (HSP) induction following heat acclimation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. Univ Maryland, Sch Med, Dept Med, Div Pulm & Crit Care, Baltimore, MD 21201 USA. VA Med Ctr, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1247 EP A1247 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326203448 ER PT J AU Mobley, AR Kantor, M Thurmond, V Mobley, SL AF Mobley, AR Kantor, M Thurmond, V Mobley, SL TI Using waist circumference and body mass index to determine risk of metabolic syndrome and glucose intolerance SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Maryland, College Pk, MD 20742 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Purdue Univ, W Lafayette, IN 47907 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1313 EP A1313 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326204266 ER PT J AU Naik, RS Belinskaya, T Doctor, BP Saxena, A AF Naik, RS Belinskaya, T Doctor, BP Saxena, A TI Cholinesterases in the milk of domestic animals SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Div Biochem, Dept Mol Pharmacol, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A898 EP A899 PN 2 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326200380 ER PT J AU Nindl, BC Tuckow, AP Harman, EA Rarick, KR Alemany, JA Staab, JS Faupel, ML Khosravi, MJ AF Nindl, BC Tuckow, AP Harman, EA Rarick, KR Alemany, JA Staab, JS Faupel, ML Khosravi, MJ TI Non-invasive sampling of interstitial fluid for the purpose of measuring IGF-I during exercise training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Environm Med Res Inst, Mil Perforance Div, Natick, MA 01760 USA. SpectRx, Norcross, GA 30071 USA. Diagnost Syst Labs Inc, Toronto, ON M5G 1X5, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A834 EP A834 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326200080 ER PT J AU Oliver, JD Atkins, JL Schooley, JF Wang, L Pamnani, MB AF Oliver, JD Atkins, JL Schooley, JF Wang, L Pamnani, MB TI Early (ES) vs. late (LS) hemorrhagic shock: response of cardiac contractility [(dp/dt)max] and ex vivo Na+,K+-ATPase (NKA) activity to resuscitation (R) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USUHS, Bethesda, MD 20814 USA. RI Atkins, James/B-3577-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1385 EP A1385 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205093 ER PT J AU Peterson, DG McClung, JP Scrimgeour, AG Koutsos, EA AF Peterson, DG McClung, JP Scrimgeour, AG Koutsos, EA TI Effects of a marginal zinc diet on intestinal health and immune function SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Calif Polytech State Univ San Luis Obispo, San Luis Obispo, CA 93407 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A985 EP A985 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201282 ER PT J AU Pole, GL Bird, DN Lim, JM Sato, AK Uyehara, CFT Claybaugh, JR AF Pole, GL Bird, DN Lim, JM Sato, AK Uyehara, CFT Claybaugh, JR TI Cardiovascular responses to hemorrhage and volume receptor control of vasopressin in rats exposed to prenatal ethanol SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Tripler Army Med Ctr, Tripler, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1444 EP A1444 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205366 ER PT J AU Schiefelbein, EL Turner, AE Mendis, C Jett, M Mendis, C AF Schiefelbein, EL Turner, AE Mendis, C Jett, M Mendis, C TI Early intervention by targeting components that inter-connect pathways in LPS induced human PBMCs SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Univ Wisconsin, Platteville, WI 53818 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A933 EP A933 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201029 ER PT J AU Shupp, JW Anderson, M Yourick, D Jett, M AF Shupp, JW Anderson, M Yourick, D Jett, M TI Immunological investigation for the apprentice scientist: Beyond cell wars SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RI Yourick, Debra/A-2121-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A977 EP A977 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326201245 ER PT J AU Tou, J Arnaud, S Brown, M Foley, A Wade, C AF Tou, J Arnaud, S Brown, M Foley, A Wade, C TI Osteopenic changes induced by ovariectomy or combination unloading and ovariectomy in aged rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 W Virginia Univ, Morgantown, WV 26506 USA. NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. Univ Missouri, Columbia, MO 65211 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1062 EP A1062 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326202106 ER PT J AU Uyehara, CFT Claybaugh, JR Coviello, LC Hashiro, GM Hernandez, CA AF Uyehara, CFT Claybaugh, JR Coviello, LC Hashiro, GM Hernandez, CA TI Vasopressin maintains tissue oxygenation in a piglet model of septic shock SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Tripler Army Med Ctr, Tripler, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1445 EP A1445 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205367 ER PT J AU Wade, CE Dubick, MA Holcomb, JB Sondeen, JL AF Wade, CE Dubick, MA Holcomb, JB Sondeen, JL TI Oxygen delivery: demand ratio is a predictor of survival in hemorrhaged swine with hypotensive resuscitation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1384 EP A1384 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205091 ER PT J AU Walters, TJ Kragh, JF Baer, DG AF Walters, TJ Kragh, JF Baer, DG TI The combined influence of hemorrhage and ischemia/reperfusion injury (I/R) on muscle function in rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1157 EP A1157 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326203050 ER PT J AU Ward, JA Sondeen, J Vela, RJ Rivera, SC Convertino, VA Holcomb, JB AF Ward, JA Sondeen, J Vela, RJ Rivera, SC Convertino, VA Holcomb, JB TI Hemorrhagic shock data mining project: Fuzzy logic model SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Brooke Army Med Ctr, Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2006 VL 20 IS 5 BP A1382 EP A1383 PN 2 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 026GA UT WOS:000236326205083 ER PT J AU Kurian, M Dasgupta, A Galvin, ME Ziegler, CR Beyer, FL AF Kurian, M Dasgupta, A Galvin, ME Ziegler, CR Beyer, FL TI A novel route to inducing disorder in model polymer-layered silicate nanocomposites SO MACROMOLECULES LA English DT Article ID MELT INTERCALATION; EPOXY NANOCOMPOSITES; MECHANICAL-PROPERTIES; POLY(ETHYLENE OXIDE); SYNTHETIC ROUTES; MONTMORILLONITE; MORPHOLOGY; HYBRID AB The effects of the degree of silicate surface modification by organic surfactants and the nature of surfactant-matrix enthalpic interactions on polymer-layered silicate nanocomposite (PLSN) morphology have been systematically investigated. Using cation exchange to modify montmorillonite, a series of '' partially '' modified clays were prepared and used in turn to fabricate polystyrene (PS)-, poly(vinyl methyl ether) (PVME)-, and poly(methyl methacrylate) (PMMA)-matrix PLSNs via static melt intercalation. Small-angle X-ray scattering and transmission electron microscopy revealed that the morphological behavior of the PS-based '' partial '' coverage PLSNs was seemingly dependent on surfactant length, with the shortest surfactant providing the most significant disruption of the clay tactoids. Examination of the PMMA- and PVME-based PLSNs indicated that the nanocomposite morphology was only weakly affected by the nature of matrix surfactant enthalpic interactions. The results of modifying montmorillonite with 5.5 kg/mol PS-based surfactant at only 4.7% coverage and subsequent fabrication of PLSNs via static melt intercalation confirmed that clay tactoids can be disordered through appropriate control of the degree of surfactant coverage for a given surfactant length. C1 Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Galvin, ME (reprint author), Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. EM galvinme@airproducts.com; flbeyer@arl.army.mil NR 49 TC 22 Z9 22 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAR 7 PY 2006 VL 39 IS 5 BP 1864 EP 1871 DI 10.1021/ma052478z PG 8 WC Polymer Science SC Polymer Science GA 018VH UT WOS:000235792400027 ER PT J AU Grinfeld, MA Schoenfeld, SE Wright, TW AF Grinfeld, MA Schoenfeld, SE Wright, TW TI Morphological instability of failure fronts SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVES; GLASS AB There are various observations and experiments showing that, in addition to standard shock-wave fronts, which propagate with high trans-sonic velocities, some other much slower wave fronts can propagate within substance undergoing intensive damage. These moving fronts propagate within intact substance leaving behind them intensively damaged substance. These fronts were coined as failure waves. The failure waves can be modeled differently-in this letter they are modeled as sharp interfaces separating two states: the intact and comminuted states. Several penetration experiments with transparent glasses and ceramics have shown that failure fronts have an extremely rough morphology. We suggest a simple thermodynamic theory which allows interpreting appearance of the roughness as a manifestation of morphological instability of failure fronts. For the case of isotropic phases the instability criterion is presented in explicit form. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Grinfeld, MA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mgreenfield@arl.army.mil NR 14 TC 9 Z9 9 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 6 PY 2006 VL 88 IS 10 AR 104102 DI 10.1063/1.2182007 PG 3 WC Physics, Applied SC Physics GA 020JV UT WOS:000235905800093 ER PT J AU Schuster, BE Wei, Q Zhang, H Ramesh, KT AF Schuster, BE Wei, Q Zhang, H Ramesh, KT TI Microcompression of nanocrystalline nickel SO APPLIED PHYSICS LETTERS LA English DT Article ID SIZE DEPENDENCE; STRENGTH; METALS; PLASTICITY; ASYMMETRY; SCALE; NI AB Microcompression is a technique that was developed as a means to probe the properties of micrometer-sized specimens using a modification of a conventional nanoindentation system. We use this technique to present the first uniaxial compressive data on electrodeposited nanocrystalline nickel (a material system where the grain size is much smaller than the specimen size). The compression-tension asymmetry of this nanocrystalline material is also discussed. C1 Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Ramesh, KT (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM ramesh@jhu.edu RI Wei, Qiuming/B-7579-2008 NR 13 TC 31 Z9 31 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 6 PY 2006 VL 88 IS 10 AR 103112 DI 10.1063/1.2183814 PG 3 WC Physics, Applied SC Physics GA 020JV UT WOS:000235905800070 ER PT J AU Anderson, DR Schroth, JM Holmes, WW AF Anderson, DR Schroth, JM Holmes, WW TI Evaluation of ilomastat, a matrix metalloprotease inhibitor, as a treatment for sulfur mustard (SM) inhalation injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A672 EP A672 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505388 ER PT J AU Barnes, B Gauthier, NA Scrimgeour, AG McClung, JP AF Barnes, B Gauthier, NA Scrimgeour, AG McClung, JP TI Effect of dietary zinc on post-absorptive activation of insulin- and stress-stimulated cellular signaling using multiplex anaylsis SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A626 EP A626 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505179 ER PT J AU Byers, C Smith, JR Bass, N Basile, N Capacio, B AF Byers, C Smith, JR Bass, N Basile, N Capacio, B TI An LC/MS method for the detection of the bispyridinium oxide MMB-4 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A100 EP A101 PN 1 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500479 ER PT J AU Cheatham, RA Lieberman, HR Das, SK Saltzman, E Gilhooly, CL Golden, JK Roberts, SB AF Cheatham, RA Lieberman, HR Das, SK Saltzman, E Gilhooly, CL Golden, JK Roberts, SB TI Effects of dietary glycemic load on mood during caloric restriction SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Tufts Univ, HNRCA, Boston, MA 02111 USA. USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A426 EP A426 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206503354 ER PT J AU Frechauf, EA Jett, M Mendis, C AF Frechauf, EA Jett, M Mendis, C TI Conformational analysis of a set of selectively screened apoptotic related genes in a SEB induced human PBMC module SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 UW Platteville, Platteville, WI 53818 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A119 EP A119 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206501020 ER PT J AU Ha, JJ Kim, B McMinn, LA Gordon, RK AF Ha, JJ Kim, B McMinn, LA Gordon, RK TI Vesicant exposed wound healing SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A535 EP A535 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504330 ER PT J AU Hammamieh, R Chakraborty, N Wang, Y Mulligan, J Jett, M AF Hammamieh, R Chakraborty, N Wang, Y Mulligan, J Jett, M TI GeneCite and PathwayScreen: web based high throughput bioinformatics search and data mining tools SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Syntek Syst Corp Inc, Gaithersburg, MD 20877 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A531 EP A531 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504313 ER PT J AU Holmes, WW Schroth, JM Anderson, DR AF Holmes, WW Schroth, JM Anderson, DR TI Evaluation of aprotinin as a treatment for sulfur mustard (SM)-induced lung injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A672 EP A672 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505387 ER PT J AU Jett, M Anderson, M Yourick, D AF Jett, M Anderson, M Yourick, D TI Use of near-peer mentoring to involve minority jr/high school students in science SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RI Yourick, Debra/A-2121-2011 NR 0 TC 1 Z9 1 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A541 EP A541 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504358 ER PT J AU Jin, XN Ray, R Cao, Y Ray, P AF Jin, XN Ray, R Cao, Y Ray, P TI Diagnosis of sulfur mustard exposure based on epidermal-dermal junction proteins (Laminin-5, integrin) degradation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Div Expt Therapeut, Dept Biol, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Cell & Mol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A515 EP A516 PN 1 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504239 ER PT J AU Kheirabadi, BS Crissey, J Deduzman, R Miranda, N Pusateri, A AF Kheirabadi, BS Crissey, J Deduzman, R Miranda, N Pusateri, A TI Effect of abdominal insufflation on parenchymal bleeding and respiratory function SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A654 EP A654 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505304 ER PT J AU McClung, JP Tarr, TN Morales-Martinez, N Scrimgeour, AG Young, AJ AF McClung, JP Tarr, TN Morales-Martinez, N Scrimgeour, AG Young, AJ TI Effect of supplemental dietary zinc on the mTOR signaling pathway in skeletal muscle from post-absorptive mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A627 EP A627 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505182 ER PT J AU Miller, SA Waddy, B Chakraborty, N Hammamieh, R Jett, M AF Miller, SA Waddy, B Chakraborty, N Hammamieh, R Jett, M TI In vitro study of breast cancer cells exposed to antisense of liver fatty acid binding protein SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A463 EP A463 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206503531 ER PT J AU Muhie, S Cummings, C Hammamieh, R Chakraborty, N Yang, D Jett, M AF Muhie, S Cummings, C Hammamieh, R Chakraborty, N Yang, D Jett, M TI Genomic investigation of the effect of physiological stress on host response to dengue, SEB and plague among Army Ranger trainees SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Georgetown Univ, Washington, DC 20057 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A62 EP A62 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500296 ER PT J AU Murgai, M Mayda, M Rios, M Hammamieh, R Jett, M AF Murgai, M Mayda, M Rios, M Hammamieh, R Jett, M TI Gene expression analysis of the West Nile virus and the dengue serotypes SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. US FDA, Rockville, MD 20857 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A62 EP A62 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500297 ER PT J AU Phillips, AT Miller, SA Gupta, E Hammamieh, R AF Phillips, AT Miller, SA Gupta, E Hammamieh, R TI In silico evaluation of a library of small molecule pharmacophore models for blocking the formation of SEB-major histocompatibility complex class II complexes SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Hood Coll, Frederick, MD 21703 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A113 EP A113 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500540 ER PT J AU Prata, CAH Barthelemy, P Li, Y Luo, D McIntosh, TJ Lee, SJ Grinstaff, MW AF Prata, CAH Barthelemy, P Li, Y Luo, D McIntosh, TJ Lee, SJ Grinstaff, MW TI Charge-resersible lipids for DNA delivery SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Annual Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Expt Therapeut C1 Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA. Boston Univ, Dept Chem, Boston, MA 02215 USA. Univ Bordeaux 2, Dept Chim, F-33076 Bordeaux, France. Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA. Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A73 EP A73 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500350 ER PT J AU Ray, R Benton, BJ Hauck, SL Carpin, C Rosenthal, DS AF Ray, R Benton, BJ Hauck, SL Carpin, C Rosenthal, DS TI Apoptosis due to sulfur mustard (SM) in human epidermal keratinocytes (NHEK) and human airway epithelial cells (HAEC): Mechanisms and intervention SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Georgetown Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC 20007 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A121 EP A121 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206501030 ER PT J AU Rubal, BJ Bauch, TD Chelen, WE Drew, GA Bulgrin, JR AF Rubal, BJ Bauch, TD Chelen, WE Drew, GA Bulgrin, JR TI Gated auscultation for teaching heart sounds SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A433 EP A433 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206503388 ER PT J AU Schafer, J Chakraborty, N Mani, S Hammamieh, R Jett, M AF Schafer, J Chakraborty, N Mani, S Hammamieh, R Jett, M TI Anthrax vaccine absorbed: genomic assessment of markers of protective immunity SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A113 EP A114 PN 1 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206500541 ER PT J AU Scrimgeour, AG Stahl, CH McClung, JP Marchitelli, LJ Young, AJ AF Scrimgeour, AG Stahl, CH McClung, JP Marchitelli, LJ Young, AJ TI Moderate zinc deficiency negatively affects biomechanical properties of rat tibiae independently of body weight SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. Iowa State Univ, Ames, IA 50011 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A627 EP A627 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505181 ER PT J AU Weng, BY Nealley, E Nau, M Sun, W Naik, R Chilukuri, N Smith, WJ Vahey, MT Doctor, BP AF Weng, BY Nealley, E Nau, M Sun, W Naik, R Chilukuri, N Smith, WJ Vahey, MT Doctor, BP TI The use of cDNA microarray analysis and alveolar macrophages to study sulfur mustard-induced lung injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Walter Reed Army Inst Res, Rockville, MD 20850 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A673 EP A673 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206505391 ER PT J AU Yeung, D Cerasoli, D Lenz, D AF Yeung, D Cerasoli, D Lenz, D TI Kinetic analysis of organophosphorus nerve agent hydrolysis by wildtype and mutant human paraoxonase 1 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Univ Maryland, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A480 EP A480 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504069 ER PT J AU Yeung, D Smith, JR Sweeney, R Cerasoli, D Lenz, D AF Yeung, D Smith, JR Sweeney, R Cerasoli, D Lenz, D TI Human paraoxonase 1 exhibits stereoselectivity in the hydrolysis of soman SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2006 Meeting CY APR 01-05, 2006 CL San Francisco, CA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut C1 USA, Med Res Inst Chem Def, Med Diagnost & Chem Branch, Aberdeen Proving Ground, MD 21010 USA. Univ Maryland, Baltimore, MD 21201 USA. Res Engn Consultants, Nottingham, PA 19362 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 6 PY 2006 VL 20 IS 4 BP A479 EP A479 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 024OW UT WOS:000236206504063 ER PT J AU Hepler, RW Kelly, R McNeely, TB Fan, HX Losada, MC George, HA Woods, A Cope, LD Bansal, A Cook, JC Zang, G Cohen, SL Wei, XR Keller, PM Leffel, E Joyce, JG Pitt, L Schultz, LD Jansen, KU Kurtz, M AF Hepler, RW Kelly, R McNeely, TB Fan, HX Losada, MC George, HA Woods, A Cope, LD Bansal, A Cook, JC Zang, G Cohen, SL Wei, XR Keller, PM Leffel, E Joyce, JG Pitt, L Schultz, LD Jansen, KU Kurtz, M TI A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection SO VACCINE LA English DT Article DE anthrax; vaccine; protective antigen ID ESCHERICHIA-COLI; GUINEA-PIGS; MONOCLONAL-ANTIBODY; RHESUS MACAQUES; SPORE CHALLENGE; LETHAL TOXIN; VACCINES; PURIFICATION; EXPRESSION; PROTEIN AB Infection by Bacillus anthracis is preventable by prophylactic vaccination with several naturally derived and recombinant vaccine preparations. Existing data suggests that protection is mediated by antibodies directed against the protective antigen (PA) component of the anthrax toxin complex. PA is an 83-kDa protein cleaved in vivo to yield a biologically active 63-kDa protein. In an effort to evaluate the potential of yeast as an expression system for the production of recombinant PA, and to determine if the yeast-purified rPA63 can protect from a lethal inhalational challenge, the sequence of the 63-kDa form of PA was codon-optimized and expressed in the yeast Saccharomyces cerevisiae. Highly purified rPA63 isolated from Saccharomyces under denaturing conditions demonstrated reduced biological activity in a macrophage-killing assay compared to non-denatured rPA83 purified from Escherichia coli. Rabbits and non-human primates (NHP) immunized with rPA63 and later challenged with a lethal dose of B. anthracis spores were generally protected from infection. These results indicate that epitopes present in the 63-kDa from of PA can protect rabbits and non-human primates from a lethal spore challenge, and further suggest that a fully functional rPA63 is not required in order to provide these epitopes. (c) 2005 Elsevier Ltd. All rights reserved. C1 Merck Res Labs, Rahway, NJ 07065 USA. Merck Res Labs, West Point, PA 19486 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Kelly, R (reprint author), Merck Res Labs, RY80Y-200,POB 2000, Rahway, NJ 07065 USA. EM rosemarie_kelly@merck.com RI Hepler, Robert/A-9664-2008 OI Hepler, Robert/0000-0003-4344-8203 NR 75 TC 17 Z9 17 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 6 PY 2006 VL 24 IS 10 BP 1501 EP 1514 DI 10.1016/j.vaccine.2005.10.018 PG 14 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 025IQ UT WOS:000236259500003 PM 16271808 ER PT J AU Jones, T Adamovicz, JJ Cyr, SL Bolt, CR Bellerose, N Pitt, LM Lowell, GH Burt, DS AF Jones, T Adamovicz, JJ Cyr, SL Bolt, CR Bellerose, N Pitt, LM Lowell, GH Burt, DS TI Intranasal Protollin (TM)/F1-V vaccine elicits respiratory and serum antibody responses and protects mice against lethal aerosolized plague infection SO VACCINE LA English DT Article DE intranasal; plague; vaccine ID ANTIGEN FUSION PEPTIDE; RECOMBINANT V-ANTIGEN; TOLL-LIKE RECEPTOR-2; YERSINIA-PESTIS; MONOCLONAL-ANTIBODIES; ACTIVE IMMUNIZATION; PNEUMONIC PLAGUE; SUBUNIT VACCINE; IMMUNE-RESPONSE; MURINE MODEL AB FIN is a recombinant plague antigen comprising the capsular (F1) and virulence-associated (V) proteins. Given intramuscularly with Alhydrogel, it protects mice against challenge, but is less effective in non-human primates against high-dose aerosolized Yersinia pestis challenge, perhaps because it fails to induce respiratory immunity. Intranasal immunization of mice with F1-V formulated with a Proteosome-based adjuvant (Protollin (TM)), elicited high titers of specific IgA in lungs whereas intranasal F1-V alone or intramuscular Alhydrogel-adsorbed F1-V did not. The Protollin-adjuvanted F1-V vaccine also induced high serum titers of specific IgG, comparable to those induced by intramuscular Alhydrogel-adsorbed F1-V. Mice immunized intranasally with Protollin-F1-V were 100% protected against aerosol challenge with 170 LD50 of Y. pestis and 80% against 255 LD50. (c) 2005 Elsevier Ltd. All rights reserved. C1 ID Biomed Corp Quebec, Montreal, PQ H7V 3S8, Canada. USA, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA. RP Jones, T (reprint author), ID Biomed Corp Quebec, 525 Cartier Blvd W, Montreal, PQ H7V 3S8, Canada. EM tjones@idbiomedical.com NR 40 TC 37 Z9 39 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 6 PY 2006 VL 24 IS 10 BP 1625 EP 1632 DI 10.1016/j.vaccine.2005.09.052 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 025IQ UT WOS:000236259500018 PM 16243411 ER PT J AU Carr, WW AF Carr, WW TI Improvements in skin-testing technique SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article; Proceedings Paper CT Postconference Symposium of the Eastern Allergy Conference CY MAY 08, 2005 CL Palm Beach, FL ID PRACTICE PARAMETERS; TEST DEVICES; ALLERGY; DIAGNOSIS; PERFORMANCE AB Allergy skin testing is the primary modality used in the diagnosis of allergic diseases and guides development of treatment and avoidance plans. The goal of the Allergist is to skin test the appropriate population with a device and technique that minimizes pain while maximizing sensitivity and specificity. The debate involving the use of intradermal versus skin-prick testing in the diagnosis of aeroallergy has been long lasting. Past and present medical literature will be reviewed, establishing the lack of diagnostic use of intradermal testing in the setting of aeroallergy. New skin devices continue to be developed with a trend toward production of multidevices. Performance characteristics of various skin test devices will be reviewed with an emphasis on sensitivity, specificity, and variability of skin-prick testing devices. Significant statistical differences exist between all devices tested and reported in the literature. Whether these statistical differences equate to clinical differences is not known. With this review the practicing allergist should carefully evaluate multiple different devices and choose a device that suits their practice needs. In addition, allergists must ensure that technicians are sufficiently trained on the correct use of their device and should conduct continuing education to ensure that proper skin testing techniques are being used in their practice. Finally, the use of skin testing in pediatrics will be reviewed with a focus on safety. Care should be taken when skin testing infants <= 6 months of age, especially in the setting of eczema and a family history of atopy. C1 Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Carr, WW (reprint author), 14588 Mustang Path, Glenwood, MD 21738 USA. EM warnercarr@hotmail.com NR 13 TC 8 Z9 8 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD MAR-APR PY 2006 VL 27 IS 2 BP 100 EP 103 PG 4 WC Allergy SC Allergy GA 037IS UT WOS:000237140900004 PM 16724625 ER PT J AU Leggit, JC Meko, CJ AF Leggit, JC Meko, CJ TI Acute finger injuries: Part I. Tendons and ligaments SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID JOINT INJURIES; INTERPHALANGEAL JOINT; HAND; MANAGEMENT; DIAGNOSIS; PITFALLS; WRIST; SPORT AB Improper diagnosis and treatment of finger injuries can cause deformity and dysfunction over time. A basic understanding of the complex anatomy of the finger and of common tendon and ligament injury mechanisms can help physicians properly diagnose and treat finger injuries. Evaluation includes a general musculoskeletal examination as well as radiography (oblique, anteroposterior, and true lateral views). Splinting and taping are effective treatments for tendon and ligament injuries. Treatment should restrict the motion of injured structures while allowing uninjured joints to remain mobile. Although family physicians are usually the first to evaluate patients with finger injuries, it is important to recognize when a referral is needed to ensure optimal outcomes. C1 Gen Leonard Wood Army Community Hosp, Ft Leonard Wood, MO USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Leggit, JC (reprint author), USA, 107 Sawmill Rd, St Robert, MO 65584 USA. EM leggit@pol.net NR 23 TC 14 Z9 15 U1 1 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 1 PY 2006 VL 73 IS 5 BP 810 EP 816 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 018SM UT WOS:000235785100012 PM 16529088 ER PT J AU Leggit, JC Meko, CJ AF Leggit, JC Meko, CJ TI Acute finger injuries: Part II. Fractures, dislocations, and thumb injuries SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID JOINT INJURIES; HAND AB Family physicians can treat most finger fractures and dislocations, but when necessary, prompt referral to an orthopedic or hand surgeon is important to maximize future function. Examination includes radiography (oblique, anteroposterior, and true lateral views) and physical examination to detect fractures. Dislocation reduction is accomplished with careful traction. If successful, further treatment focuses on the concomitant soft tissue injury. Referral is needed for irreducible dislocations. Distal phalanx fractures are treated conservatively, and middle phalanx fractures can be treated if reduction is stable. Physicians usually can reduce metacarpal bone fractures, even if there is a large degree of angulation. An orthopedic or hand surgeon should treat finger injuries that are unstable or that have rotation. Collateral ligament injuries of the thumb should be examined with radiography before physical examination. Stable joint injuries can be treated with splinting or casting, although an orthopedic or hand surgeon should treat unstable joints. C1 Gen Leonard Wood Army Community Hosp, Ft Leonard Wood, MO USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Leggit, JC (reprint author), USA, 107 Sawmill Rd, St Robert, MO 65584 USA. EM leggit@pol.net NR 17 TC 10 Z9 10 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 1 PY 2006 VL 73 IS 5 BP 827 EP 834 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 018SM UT WOS:000235785100013 PM 16529090 ER PT J AU Szebeni, J Baranyi, L Savay, S Bodo, M Milosevits, J Alving, CR Bunger, R AF Szebeni, J Baranyi, L Savay, S Bodo, M Milosevits, J Alving, CR Bunger, R TI Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE adenosine receptors; allergy; anaphylactoid reactions; bezold-jarisch reflex; electrocardiography; cyclopentyl-xanthine; hemodynamic changes; hypersensitivity reactions; pseudoallergy ID MAST-CELLS; IMMUNOLOGICAL CHARACTERIZATION; HYPERSENSITIVITY REACTIONS; MYOCARDIAL-FUNCTION; PACLITAXEL; INHIBITION; SYSTEM; PSEUDOALLERGY; ARRHYTHMIAS; BRADYCARDIA AB Cardiac anaphylaxis is a severe, life-threatening manifestation of acute hypersensitivity reactions to allergens and drugs. Earlier studies highlighted an amplifying effect of locally applied C5a on the process; however, the role of systemic complement (C) activation with C5a liberation in blood has not been explored to date. In the present study, we used the porcine liposome-induced cardiopulmonary distress model for 1) characterizing and quantifying peripheral C activation-related cardiac dysfunction; 2) exploring the role of C5a in cardiac abnormalities and therapeutic potential of C blockage by soluble C receptor type 1 (sCR1) and an anti-C5a antibody (GS1); and 3) elucidating the role of adenosine and adenosine receptors in paradoxical bradycardia, one of the symptoms observed in this model. Pigs were injected intravenously with different liposomes [Doxil and multilamellar vesicles (MLV)], zymosan, recombinant human (rhu) C5a, and adenosine, and the ensuing hemodynamic and cardiac changes (hypotension, tachy- or bradycardia, arrhythmias, ST-T changes, ventricular fibrillation, and arrest) were quantified by ranking on an arbitrary scale [cardiac abnormality score (CAS)]. There was significant correlation between CAS and C5a production by liposomes in vitro, and the liposome-induced cardiac abnormalities were partially or fully reproduced with zymosan, rhuC5a, adenosine, and the selective adenosine A(1) receptor agonist cyclopentyl-adenosine. The use of C nonactivator liposomes or pretreatment of pigs with sCR1 or GS1 attenuated the abnormalities. The selective A(1) blocker cyclopentylxanthine inhibited bradycardia without influencing hypotension, whereas the A(2) blocker 4-(2-{7-amino-2-(2-furyl)[1,2,4] triazolo[2,3-a] [1,3,5] triazin-5-ylamino} ethyl) phenol (ZM-24135) had no such effect. These data suggest that 1) systemic C activation can underlie cardiac anaphylaxis, 2) C5a plays a causal role in the reaction, 3) adenosine action via A(1) receptors may explain paradoxical bradycardia, and 4) inhibition of C5a formation or action or of A(1)-receptor function may alleviate the acute cardiotoxicity of liposomal drugs and other intravenous agents that activate C. C1 US Mil HIV Res Program, Dept Vaccine Prod & Delivery, Div Retrovirol, Rockville, MD 20850 USA. Walter Reed Army Med Ctr, Vacine & Immunol Res Inst, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Resuscitat Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Membrane Biochem, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. RP Szebeni, J (reprint author), US Mil HIV Res Program, Dept Vaccine Prod & Delivery, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. EM jszebeni@hivresearch.org NR 52 TC 47 Z9 48 U1 1 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD MAR PY 2006 VL 290 IS 3 BP H1050 EP H1058 DI 10.1152/ajpheart.00622.2005 PG 9 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA 010RI UT WOS:000235212400017 PM 16214844 ER PT J AU Banks, KP Brown, SJ AF Banks, KP Brown, SJ TI AJR teaching file: Solid masses of the pineal region SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE germ cell tumors; germinoma; MRI; neuroradiology; pineal gland ID CHILDREN; TUMORS C1 USA, MCHE, DR, Ft Sam Houston, TX 78234 USA. RP Banks, KP (reprint author), USA, MCHE, DR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Kevin.Banks@amedd.army.mil NR 4 TC 1 Z9 2 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 2006 VL 186 IS 3 SU S BP S233 EP S235 DI 10.2214/AJR.050519 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 017IW UT WOS:000235688300006 PM 16498141 ER PT J AU Roberts, CC Banks, KP Hesselink, JR Chew, FS AF Roberts, CC Banks, KP Hesselink, JR Chew, FS TI Imaging of the pineal region and spine: Self-assessment module SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE brain tumors; neuroradiology; oncologic imaging; pineal region; spine ID FEATURES AB The educational objectives for this self-assessment module on imaging of the pineal region and spine are for the participant to exercise, self-assess, and improve his or her understanding of the evaluation of patients with brain tumors, particularly solid masses of the pineal region; gain familiarity with the clinical entity of chronic inflammatory demyelinating polyradiculo-neuropathy (CIDP) and its radiologic appearance; and gain familiarity with the clinical entity of spinal dural arteriovenous fistula (DAVF) and its radiologic appearance. C1 Univ Washington, Dept Radiol, Seattle, WA 98105 USA. Mayo Clin, Coll Med, Dept Radiol, Scottsdale, AZ USA. Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. RP Chew, FS (reprint author), Univ Washington, Dept Radiol, 4245 Roosevelt Way NE,Box 354755, Seattle, WA 98105 USA. RI Roberts, Catherine/B-5502-2014 OI Roberts, Catherine/0000-0001-5722-7108 NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 2006 VL 186 IS 3 SU S BP S224 EP S226 DI 10.2214/AJR.05.2231 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 017IW UT WOS:000235688300003 PM 16498138 ER PT J AU Miller, RS Wongsrichanalai, C Buathong, N McDaniel, P Walsh, DS Knirsch, C Ohrt, C AF Miller, RS Wongsrichanalai, C Buathong, N McDaniel, P Walsh, DS Knirsch, C Ohrt, C TI Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: A randomized, dose-ranging study SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIMALARIAL-DRUG-RESISTANCE; CONTROLLED TRIAL; DOUBLE-BLIND; IN-VITRO; PROPHYLAXIS; CHLOROQUINE; ARTESUNATE; PREGNANCY; CLINDAMYCIN; THAILAND AB Azithromycin, the most potent antimalarial macrolide antibiotic, is synergistic with quinine against Plasmodium falciparum in vitro. We assessed combinations of azithromycin and quinine against uncomplicated P. falciparum malaria at the Armed Forces Research Institute of Medical Sciences - Kwai River Clinical Center along the Thailand-Myanmar border, an area with a high prevalence of multidrug-resistant P. falciparum. Four regimens were assessed in an open-label dose-ranging design involving 61 volunteers. All received oral quinine (Q; 30 mg/kg/day divided every 8 hours for 3 days) with oral azithromycin (Az; 500 mg twice a day for 3 days, 500 mg twice a day for 5 days, or 500 mg three times a day for 3 days). A comparator group received quinine and doxycycline (Dx; 100 mg twice a day for 7 days). Study observation was 28 days per protocol. Sixty volunteers completed the study. Seven days of QDx cured tOO% of the volunteers. One failure occurred in the lowest QAz regimen (on day 28) and none occurred in either of the two higher Az regimens. Cinchonism occurred in nearly all subjects. Overall, the azithromycin regimens were well tolerated, and no volunteers discontinued therapy. Three- and five-day azithromycin-quinine combination therapy appears safe well tolerated, and effective in curing drug-resistant P. falciparum malaria. Further evaluation, especially in pediatric an obstetric populations, is warranted. C1 USA, Armed Forces Inst Med Sci, Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. Kwai River Christian Hosp, Sangkhlaburi, Kanchanaburi, Thailand. Pfizer Inc, New York, NY USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Miller, RS (reprint author), USA, Armed Forces Inst Med Sci, Med Component, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM robert.s.miller@us.army.mil; chansuda@namru2.med.navy.mil; nillawanb@afrims.org; philmcd@concentric.net; douglas.walsh@us.army.mil; charles.knirsch@pfizer.com; colin.ohrt@us.army.mil NR 34 TC 47 Z9 49 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2006 VL 74 IS 3 BP 401 EP 406 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 020PY UT WOS:000235923300009 PM 16525097 ER PT J AU DeBlasio, D Hansen, K Walbel, KH AF DeBlasio, D Hansen, K Walbel, KH TI Periorbital swelling and nasal congestion in a 31-year-old man SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID ALLERGIC FUNGAL SINUSITIS; SINONASAL SARCOIDOSIS; DIAGNOSTIC-CRITERIA; MANIFESTATIONS; DISORDERS; SINUSES; EDEMA; EYE C1 Eisenhower Army Med Ctr, Allergy & Immunol Serv, Dept Med, Ft Gordon, GA 30905 USA. Eisenhower Army Med Ctr, Serv Otolaryngol, Dept Surg, Ft Gordon, GA 30905 USA. RP Walbel, KH (reprint author), Eisenhower Army Med Ctr, Allergy & Immunol Serv, Dept Med, 300 Hosp Rd,8th Floor, Ft Gordon, GA 30905 USA. EM kirk.walbel@se.amedd.army.mil NR 32 TC 0 Z9 0 U1 0 U2 1 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD MAR PY 2006 VL 96 IS 3 BP 489 EP 493 PG 5 WC Allergy; Immunology SC Allergy; Immunology GA 026XU UT WOS:000236377400020 PM 16597086 ER PT J AU Crystal, CS Coon, TP Kaylor, DW AF Crystal, CS Coon, TP Kaylor, DW TI Images in emergency medicine - Acute necrotizing ulcerative gingivitis SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material C1 Darnall Army Community Hosp, Dept Emergency Med, Ft Hood, TX 76544 USA. Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Crystal, CS (reprint author), Darnall Army Community Hosp, Dept Emergency Med, Ft Hood, TX 76544 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD MAR PY 2006 VL 47 IS 3 BP 225 EP + DI 10.1016/j.annemergemed.2005.06.448 PG 2 WC Emergency Medicine SC Emergency Medicine GA 020OP UT WOS:000235919500002 PM 16492485 ER PT J AU Enterlein, S Warfield, KL Swenson, DL Stein, DA Smith, JL Gamble, CS Kroeker, AD Iversen, PL Bavari, S Muhlberger, E AF Enterlein, S Warfield, KL Swenson, DL Stein, DA Smith, JL Gamble, CS Kroeker, AD Iversen, PL Bavari, S Muhlberger, E TI VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTISENSE MORPHOLINO-OLIGOMERS; MARBURG-VIRUS; NUCLEOCAPSID PROTEINS; MOUSE MODEL; REPLICATION; TRANSCRIPTION; PROPHYLAXIS; ANTIBODIES; THERAPY; MONKEYS AB Phosphorodiamidate morpholino oligomers (PMO) are a class of uncharged single-stranded DNA analogs modified such that each subunit includes a phosphorodiamidate linkage and morpholine ring. PMO antisense agents have been reported to effectively interfere with the replication of several positive-strand RNA viruses in cell culture. The filoviruses, Marburg virus and Ebola virus (EBOV), are negative-strand RNA viruses that cause up to 90% lethality in human outbreaks. There is currently no commercially available vaccine or efficacious therapeutic for any filovirus. In this study, PMO conjugated to arginine-rich cell-penetrating peptide (P-PMO) and nonconjugated PMO were assayed for the ability to inhibit EBOV infection in cell culture and in a mouse model of lethal EBOV infection. A 22-mer P-PMO designed to base pair with the translation start site region of EBOV VP35 positive-sense RNA generated sequence-specific and time- and dose-dependent inhibition of EBOV amplification in cell culture. The same oligomer provided complete protection to mice when administered before or after an otherwise lethal infection of EBOV. A corresponding nonconjugated PMO, as well as nonconjugated truncated versions of 16 and 19 base residues, provided length-dependent protection to mice when administered prophylactically. Together, these data suggest that antisense PMO and P-PMO have the potential to control EBOV infection and are promising therapeutic candidates. C1 Univ Marburg, Dept Virol, D-35043 Marburg, Germany. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. AVI BioPharma Inc, Corvallis, OR USA. RP Bavari, S (reprint author), Univ Marburg, Dept Virol, Hans Meerwein Str 3, D-35043 Marburg, Germany. EM sina.bavari@us.army.mil; muehlber@staff.uni-marburg.de OI Gamble, Christopher/0000-0002-2094-205X NR 43 TC 78 Z9 81 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2006 VL 50 IS 3 BP 984 EP 993 DI 10.1128/AAC.503.984-993.2006 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 018SY UT WOS:000235786300023 PM 16495261 ER PT J AU Dow, G Bauman, R Caridha, D Cabezas, M Du, F Gomez-Lobo, R Park, M Smith, K Cannard, K AF Dow, G Bauman, R Caridha, D Cabezas, M Du, F Gomez-Lobo, R Park, M Smith, K Cannard, K TI Mefloquine induces dose-related neurological effects in a rat model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ACUTE FALCIPARUM-MALARIA; ADVERSE EVENTS; P-GLYCOPROTEIN; ANTIMALARIAL; CHANNELS; PHARMACOKINETICS; ENANTIOMERS; ARTESUNATE; ARTEETHER; TOXICITY AB Mefloquine is one of the drugs approved by the FDA for malaria chemoprophylaxis. Mefloquine is also approved for the treatment of malaria and is widely used for this purpose in combination with artesunate. However, the clinical utility of the compound has been compromised by reports of adverse neurological effects in some patients. In the present study, the potential neurological effects of mefloquine were investigated with six 7-week-old female rats given a single oral dose of the compound. Potential mefloquine-induced neurological effects were monitored using a standard functional observational battery, automated open field tests, automated spontaneous activity monitoring, a beam traverse task, and histopathology. Plasma mefloquine concentrations were determined 72 It after dosing by using liquid chromatography-mass spectrometry. Mefloquine induced dose-related changes in endpoints associated with spontaneous activity and impairment of motor function and caused degeneration of specific brain stem nuclei (nucleus gracilis). Increased spontaneous motor activity was observed only during the rats' normal sleeping phase, suggesting a correlate to mefloquine-induced sleep disorders. The threshold dose for many of these effects was 187 mg/kg of body weight. This dose yielded plasma mefloquine concentrations after 72 h that are similar to those observed in humans after the treatment dose. Collectively, these data suggest that there may be a biological basis for some of the clinical neurological effects associated with mefloquine. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. FD NEurotechnol Inc, Ellicott City, MD 21041 USA. RP Dow, G (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM geoffrey.dow@na.amedd.army.mil NR 46 TC 31 Z9 32 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2006 VL 50 IS 3 BP 1045 EP 1053 DI 10.1128/AAC.50.3.1045-1053.2006 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 018SY UT WOS:000235786300029 PM 16495267 ER PT J AU Pliner, P Bell, R Hirsch, ES Kinchla, M AF Pliner, P Bell, R Hirsch, ES Kinchla, M TI Meal duration mediates the effect of "social facilitation" on eating in humans SO APPETITE LA English DT Article DE group size effect; social facilitation; food intake; time extension; human eating behavior; social influence; modeling ID FOOD-INTAKE; NORMAL-WEIGHT; SIZE; WOMEN; MEN; OVERWEIGHT; PEOPLE; HYPOTHESIS; PATTERNS; FRIENDS AB This experiment examined the 'time extension' explanation for the social facilitation effect, which is that people eat more as the number of co-eaters increases. Seventy male and 62 female participants ate a lunch consisting of pizza, cookies, and bottled water, alone or in (same-gender) groups of two or four and were given either 12 or 36 min in which to do so. The independent variables were gender, group size, and meal duration. The main dependent variable was amount consumed in the meal. The results showed that male participants ate more than did females, and participants eating the longer meal ate more than did those eating the shorter meal. However, the effect of group size was not significant. It was also the case that the amounts consumed by participants eating in two-person groups resembled one another to a greater extent than did of pairs of participants who ate alone or by participants in four-person groups. It was concluded that the results of the present paper provide strong support for the idea that the effect of group size on intake seen in previous studies is mediated by meal duration. (c) 2006 Published by Elsevier Ltd. C1 Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada. USA, Natick Solier Ctr, Natick, MA 01760 USA. RP Pliner, P (reprint author), Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada. EM pliner@psych.utoronto.ca NR 35 TC 32 Z9 35 U1 2 U2 10 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD MAR PY 2006 VL 46 IS 2 BP 189 EP 198 DI 10.1016/j.appet.2005.12.003 PG 10 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 027ND UT WOS:000236421400010 PM 16500000 ER PT J AU Nowlin, TP Freeman, JH Cable, B AF Nowlin, TP Freeman, JH Cable, B TI Pathology quiz case: Diagnosis SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID EPITHELIOID CELL NEVI; SPITZ-NEVI; MELANOMA; SPINDLE; LESIONS; ADULT; TUMOR C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Nowlin, TP (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAR PY 2006 VL 132 IS 3 BP 349 EP 351 DI 10.1001/archotol.132.3.349 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 023IK UT WOS:000236120100017 PM 16549759 ER PT J AU Flood, KM Huang, ME Roberts, TL Pasquina, PF Nelson, VS Bryant, PR AF Flood, KM Huang, ME Roberts, TL Pasquina, PF Nelson, VS Bryant, PR TI Limb deficiency and prosthetic management. 2. Aging with limb loss SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE aging; amputation; artificial limbs; complications; outcome assessment (health care); rehabilitation ID AMPUTEE PATIENT; RISK-FACTORS; AMPUTATION; REHABILITATION; POPULATION; VETERANS; PAIN AB This self-directed learning module highlights the issues faced by people aging with limb loss. It is part of the study guide on limb deficiency and vascular rehabilitation in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article specifically focuses on the impact that limb loss has on health and physical function throughout the life span. Case examples are used to illustrate what effect limb loss in childhood or young adulthood has on the incidence and management of new impairments or disease processes commonly associated with aging. Overall Article Objective: To discuss the impact of early-life limb loss on the incidence and management of physiologic and functional changes associated with aging. C1 VA Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, Pittsburgh, PA 15240 USA. Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. George E Wahlen Dept Vet Affairs Med Ctr, Phys Med & Rehabil Serv, Salt Lake City, UT USA. Walter Reed Army Med Ctr, Phys Med & Rehabil Serv, Washington, DC 20307 USA. Univ Michigan, Sch Med, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. Good Shepherd Rehabil Hosp, Allentown, PA USA. RP Flood, KM (reprint author), VA Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, 132Y-A,Univ Dr C, Pittsburgh, PA 15240 USA. EM vze2zn62@verizon.net NR 33 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2006 VL 87 IS 3 SU 1 BP S10 EP S14 DI 10.1016/j.apmr.2005.11.023 PG 5 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 024PK UT WOS:000236208200003 PM 16500188 ER PT J AU Huang, ME Nelson, VS Flood, KM Roberts, TL Bryant, PR Pasquina, PF AF Huang, ME Nelson, VS Flood, KM Roberts, TL Bryant, PR Pasquina, PF TI Limb deficiency and prosthetic management. 3. Complex limb deficiency SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE amputation; artificial limbs; burns; multiple trauma; rehabilitation ID KNEE AMPUTATION LEVEL; ELECTRICAL BURNS; UPPER EXTREMITY; REHABILITATION; INJURIES; AMPUTEE; SALVAGE; SKIN AB This self-directed learning module highlights rehabilitation and prosthetic issues associated with complex limb deficiencies. It is part of the chapter on acquired limb deficiencies in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article discusses rehabilitation and prosthetic management of patients with amputations for complex limb deficiencies secondary to trauma. Mechanisms of injury, prosthetic issues, prosthetic components, and potential problems in prosthetic fitting will be discussed. Overall Article Objective: To evaluate common problems associated with complex limb deficiency. C1 Northwestern Univ, Rehabil Inst Chicago, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. Univ Michigan, Sch Med, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. Vet Affairs Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, Pittsburgh, PA USA. George E Wahlen Dept Vet Affairs, Med Ctr, Phys Med & Rehabil Serv, Salt Lake City, UT USA. Good Shepherd Rehabil Hosp, Allentown, PA USA. Walter Reed Army Med Ctr, Phys Med & Rehabil Serv, Washington, DC 20307 USA. RP Huang, ME (reprint author), Northwestern Univ, Rehabil Inst Chicago, Feinberg Sch Med, Dept Phys Med & Rehabil, 345 E Super St, Chicago, IL 60611 USA. EM mhuang@ric.org NR 34 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2006 VL 87 IS 3 SU 1 BP S15 EP S20 DI 10.1016/j.apmr.2005.11.024 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 024PK UT WOS:000236208200004 PM 16500189 ER PT J AU Nelson, VS Flood, KM Bryant, PR Huang, ME Pasquina, PF Roberts, TL AF Nelson, VS Flood, KM Bryant, PR Huang, ME Pasquina, PF Roberts, TL TI Limb deficiency and prosthetic management. 1. Decision making in prosthetic prescription and management SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE amputation; artificial limbs; limb deformities, congenital; prostheses and implants; rehabilitation AB Limb deficiency and prosthetic management. 1. Decision making in prosthetic prescription and management. C1 Univ Michigan, Sch Med, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. Vet Affairs Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, Pittsburgh, PA USA. Good Shepherd Rehabil Hosp, Allentown, PA USA. Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. Walter Reed Army Med Ctr, Phys Med & Rehabil Serv, Washington, DC 20307 USA. George E Wahlen Dept Vet Affairs Med Ctr, Phys Med & Rehabil Serv, Salt Lake City, UT USA. RP Nelson, VS (reprint author), Dept PM&R, 325 E Eisenhower, Ann Arbor, MI 48108 USA. EM vsnelson@umich.edu NR 21 TC 16 Z9 17 U1 4 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2006 VL 87 IS 3 SU 1 BP S3 EP S9 DI 10.1016/j.apmr.2005.11.022 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 024PK UT WOS:000236208200002 PM 16500187 ER PT J AU Pasquina, PF Bryant, PR Huang, ME Roberts, TL Nelson, VS Flood, KM AF Pasquina, PF Bryant, PR Huang, ME Roberts, TL Nelson, VS Flood, KM TI Advances in amputee care SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Review DE amputation; prosthetics and implants; rehabilitation; review [publication type] ID DIFFERENT PROSTHETIC COMPONENTS; LOWER-LIMB AMPUTATIONS; TRANS-FEMORAL AMPUTEE; BELOW-KNEE AMPUTEES; QUALITY-OF-LIFE; ENERGY-EXPENDITURE; INTELLIGENT PROSTHESIS; TRANSFEMORAL AMPUTEES; HAND TRANSPLANTATION; OUTCOME MEASURE AB This self-directed learning module highlights the recent in novations in amputee care. It is part of the study guide on limb deficiency in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This focused review article describes the key elements of a successful comprehensive amputee program, the basic surgical considerations for upper- and lower-extremity amputation, and some of the more recent advances in prosthetic components. Further, an update is given on issues such as hand transplantation and the integration of robotics and artificial muscles for people with limb loss. Overall Article Objective: (a) To discuss current issues and advances in the care of patients with amputation, (b) to describe the key elements in designing a comprehensive amputee care program, and (c) to discuss surgical considerations of limb preservation and amputation levels. C1 Walter Reed Army Med Ctr, Sect 3J, Phys Med & Rehabil Serv, Washington, DC 20307 USA. Good Shepherd Rehabil Hosp, Allentown, PA USA. Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. George E Wahlen Dept Vet Affairs, Med Ctr, Salt Lake City, UT USA. Univ Michigan, Sch Med, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. Vet Affairs Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, Pittsburgh, PA USA. RP Pasquina, PF (reprint author), Walter Reed Army Med Ctr, Sect 3J, Phys Med & Rehabil Serv, Bldg 2,6900 Georgia Ave, Washington, DC 20307 USA. EM Paul.Pasquina@NA.AMEDD.ARMY.MIL NR 86 TC 27 Z9 29 U1 1 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2006 VL 87 IS 3 SU 1 BP S34 EP S43 DI 10.1016/j.apmr.2005.11.026 PG 10 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 024PK UT WOS:000236208200006 PM 16500191 ER PT J AU Roberts, TL Pasquina, PF Nelson, VS Flood, KM Bryant, PR Huang, ME AF Roberts, TL Pasquina, PF Nelson, VS Flood, KM Bryant, PR Huang, ME TI Limb deficiency and prosthetic management. 4. Comorbidities associated with limb loss SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE amputation; comorbidity; outcome assessment (health care); pain; rehabilitation ID PERIPHERAL-ARTERIAL-DISEASE; LOWER-EXTREMITY AMPUTATIONS; REHABILITATION; DEPRESSION; ADULTS; DISABILITY; AMPUTEES; PATIENT; POPULATION; PREVALENCE AB This self-directed learning module highlights common comorbidities found in people with amputations and their impact on functional outcome. It is part of the study guide on limb deficiency and vascular rehabilitation in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article focuses on prosthetic considerations, functional outcome, and potential complications for a woman with the comorbidities of stroke and diabetes who experiences a dysvascular amputation. Formulation of the differential diagnosis, management of limb pain, and evaluation of the potential psychosocial issues arising after amputation are also discussed. Overall Article Objective: To analyze common comorbidities of people with amputations and to delineate their impact on functional outcome. C1 George E Wahlen Dept Vet Affairs, Med Ctr, Phys Med & Rehabil Serv, Salt Lake City, UT 84148 USA. Walter Reed Army Med Ctr, Phys Med & Rehabil Serv, Washington, DC 20307 USA. Univ Michigan, Sch Med, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. Vet Affairs Pittsburgh Healthcare Syst, Phys Med & Rehabil Program, Pittsburgh, PA USA. Good Shepherd Rehabil Hosp, Allentown, PA USA. Northwestern Univ, Rehabil Inst Chicago, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. RP Roberts, TL (reprint author), George E Wahlen Dept Vet Affairs, Med Ctr, Phys Med & Rehabil Serv, 500 Foothill Blvd,117, Salt Lake City, UT 84148 USA. EM Toni.Roberts@med.va.gov NR 51 TC 11 Z9 11 U1 2 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 2006 VL 87 IS 3 SU 1 BP S21 EP S27 DI 10.1016/j.apmr.2005.11.025 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 024PK UT WOS:000236208200005 PM 16500190 ER PT J AU Lindsey, CY Pace-Templeton, JG Millard, CB Wannemacher, RW Hewetson, JF AF Lindsey, CY Pace-Templeton, JG Millard, CB Wannemacher, RW Hewetson, JF TI Validation of ELISA for the determination of anti-ricin immunoglobulin G concentration in mouse sera SO BIOLOGICALS LA English DT Article DE validation; ELISA; ricin vaccine; anti-ricin IgG ID POLYMERIC MICROSPHERES; VACCINE; CHALLENGE; MICE AB An enzyme-linked immunosorbent assay (ELISA) for the determination of anti-ficin immunoglobulin G (IgG) concentration in mouse sera was systematically validated. The results obtained throughout the validation process strongly demonstrated that the ELISA was reliable, reproducible, and suitable for its intended use. The assay had a high level of precision within and between runs, was specific for the anti-ficin IgG, and showed no interference with a number of different scrum matrices. The assay exhibited excellent accuracy, linearity, and stability. The mean recovery of four test samples with different known concentrations was 100.9 +/- 11.3%, 102.7 +/- 10.8%, 99.0 +/- 7.2%. and 95.9 +/- 11.3%, respectively (n = 10). The mean recovery of the observed anti-ricin IgG concentration of three quality control samples run on 73 plates to their nominal concentrations was 100.1 +/- 7.3%, 100.2 +/- 5.8%, and 103.7 +/- 8.1%; and the coefficient of variation (CV) was 7.3%, 5.8%, and 7.8%, respectively. The back-calculated anti-ricin IgG concentration. %CV, and relative error of seven standards from the calibration curves run in the entire validation Study were analyzed (n = 7 X 73). The results indicated that the four-parameter logistic (4PL) equation, y = (a - d)/(1 + (xl c)(b)) + d, provided an accurate representation of a sigmoidal relationship between the measured response and the logarithm of observed concentration of anti-ricin IgG in mouse sera for this ELISA. The lower limit of quantification and tipper limit of quantification of the calibration curve were 3.3 ng/ml and 82.8 ng/ml, respectively. The measurable range of the assay would cover all possible anti-ricin IgG concentrations in mouse sera stimulated with a ricin vaccine candidate, when the test sera are measured at a 1:800 starting dilution followed by four additional fourfold serial dilutions. Published by Elsevier Ltd on behalf of The International Association for Biologicals. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Lindsey, CY (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM changhong.lindsey@amedd.army.mil NR 19 TC 11 Z9 13 U1 1 U2 5 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1045-1056 J9 BIOLOGICALS JI Biologicals PD MAR PY 2006 VL 34 IS 1 BP 33 EP 41 DI 10.1016/j.biologicals.2005.08.018 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy GA 025JB UT WOS:000236260600006 PM 16260147 ER PT J AU Ibrahim, R Frederickson, H Parr, A Ward, Y Moncur, J Khleif, SN AF Ibrahim, R Frederickson, H Parr, A Ward, Y Moncur, J Khleif, SN TI Expression of FasL in squamous cell carcinomas of the cervix and cervical intraepithelial neoplasia and its role in tumor escape mechanism SO CANCER LA English DT Article DE FasL; CD95L; tumor escape mechanisms; cervical carcinoma; immuno-histochemistry; Fas/FasL ID CYTOTOXIC T-LYMPHOCYTES; APO-1/CD95 LIGAND; CANCER-CELLS; IMMUNE PRIVILEGE; IN-VIVO; APOPTOSIS; COUNTERATTACK; ADENOCARCINOMAS; MICROVESICLES; ANTIGENS AB BACKGROUND. To date, several mechanisms have been described by which malignant cells escape from the immune system. One of these is through the expression of FasL. The authors hypothesized that the Fas/FasL interaction enables cervical carcinoma cells to induce apoptosis of the cells of the immune system and thereby escape from them. METHODS. The authors tested the expression of FASL on the Surface of cervical carcinoma tissues. Next, they stained the same cervical tissues with anti-human leukocyte common antigen and TUNEL to identify, apoptotic cells. All in vitro functional assay was then done to test if the FASL expressed oil the surface of cervical carcinoma cell lines was or was not responsible for inducing apoptosis in T-cells. Finally, they compared the expression of FASL on normal and dysplastic cervical tissues. RESULTS. Ninety-four percent of the cervical carcinoma tissues the authors tested expressed FasL and the majority of the apoptotic cells in the specimens were leukocytes with very few tumor cells. In the in vitro functional assay, only the Fasl expressing cell line and not the Fasl negative cell line was able to induce apoptosis of the Fas-expressing Jurkat cells. On examining the normal cervical tissues, the authors found that the expression of Fasl was confined to the basal cell layer with loss of expression observed in the suprabasal layers, which made it an immune privileged site. Conversely, there was persistent expression of Fast, in the dysplastic layers in cervical dysplasia and squamous cell carcinoma specimens. CONCLUSIONS. The findings of the current study support the authors' hypothesis that persistent expression of Fast, plays a role in the ability of cervical carcinoma cells to escape from the immune system. C1 NCI, Ctr Canc Res, Natl Naval Med Ctr, Canc Vaccine Branch,NIH, Bethesda, MD 20889 USA. NCI, Ctr Canc Res, Canc Therapeut Branch, Bethesda, MD 20889 USA. NCI, Cell & Canc Biol Branch, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Khleif, SN (reprint author), NCI, Ctr Canc Res, Natl Naval Med Ctr, Canc Vaccine Branch,NIH, 8901 Wisconsin Ave,Bldg 8,Room 5101, Bethesda, MD 20889 USA. EM khleif@nih.gov NR 33 TC 15 Z9 20 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD MAR 1 PY 2006 VL 106 IS 5 BP 1065 EP 1077 DI 10.1002/cncr.21697 PG 13 WC Oncology SC Oncology GA 019GD UT WOS:000235822700012 PM 16456813 ER PT J AU Kuperman, RG Checkai, RT Simini, M Phillips, CT Anthony, JS Kolakowski, JE Davis, EA AF Kuperman, RG Checkai, RT Simini, M Phillips, CT Anthony, JS Kolakowski, JE Davis, EA TI Toxicity of emerging energetic soil contaminant CL-20 to potworm Enchytraeus crypticus in freshly amended or weathered and aged treatments SO CHEMOSPHERE LA English DT Article DE CL-20; enchytraeid worm; toxicity in natural soil; weathering and aging ID HETEROCYCLIC EXPLOSIVES RDX; 2,4,6-TRINITROTOLUENE TNT; FOREST SOIL; BIOTRANSFORMATION; HMX; DEGRADATION; REPRODUCTION; METABOLITES; SURVIVAL; BIODEGRADATION AB We investigated the toxicity of an emerging polynitramine energetic material hexanitrohexaazaisowurtzitane (CL-20) to the soil invertebrate species Enchytraeus crypticus by adapting then using the Enchytraeid Reproduction Test (ISO/16387:2003). Studies were designed to develop ecotoxicological benchmark values for ecological risk assessment of the potential impacts of accidental release of this compound into the environment. Tests were conducted in Sassafras Sandy Loam soil, which supports relatively high bioavailability of CL-20. Weathering and aging procedures for CL-20 amended into test soil were incorporated into the study design to produce toxicity data that better reflect soil exposure conditions in the field compared with the toxicity in freshly amended soils. Concentration-response relationships for measurement endpoints were determined using nonlinear regressions. Definitive tests showed that toxicities for E. crypticus adult survival and juvenile production were significantly increased in weathered and aged soil treatments compared with toxicity in freshly amended soil, based on 95% confidence intervals. The median effect concentration (EC(50)) and EC(20) values for juvenile production were 0.3 and 0. 1 mg kg(-1), respectively, for CL-20 freshly amended into soil, and 0. 1 and 0.035 mg kg(-1), respectively, for weathered and aged CL-20 soil treatments. These findings of increased toxicity to E crypticus in weathered and aged CL-20 soil treatments compared with exposures in freshly amended soils show that future investigations should include a weathering and aging component to generate toxicity data that provide more complete information on ecotoxicological effects of emerging energetic contaminants in soil. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Edgewood Chem Biol Ctr, AMSRD, ECB,RTTE, Aberdeen Proving Ground, MD 21010 USA. RP Kuperman, RG (reprint author), USA, Edgewood Chem Biol Ctr, AMSRD, ECB,RTTE, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM roman.kuperman@us.army.mil RI Kuperman, Roman/D-4297-2009; OI Kuperman, Roman/0000-0001-5344-1633 NR 51 TC 13 Z9 15 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2006 VL 62 IS 8 BP 1282 EP 1293 DI 10.1016/j.chemosphere.2005.07.008 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA 022ZX UT WOS:000236095900009 PM 16213571 ER PT J AU Jones, RP Millward, RN Karn, RA Harrison, AH AF Jones, RP Millward, RN Karn, RA Harrison, AH TI Microscale analytical methods for the quantitative detection of PCBs and PAHs in small tissue masses SO CHEMOSPHERE LA English DT Article DE microscale extraction; PCBs; PAHs; tissues ID BIOACCUMULATION; HYDROCARBONS AB Microscale methods (MM) were evaluated and compared to traditional methods (TM) for measuring polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in spiked and standard reference fish and mussel tissues. MMs are advantageous because they use small tissue masses (ca. 100 mg), and maintain sensitivity through reducing final extract volume (traditionally 1 ml) by an order of magnitude or more (40 mu l-PCBs; 100 mu l-PAHs). Procedural losses occurred in the MMs'combined cleanup/primary evaporation step (19% PAHs; 6%, PCBs), and the final extract concentration (14% PAHs; 22% PCBs). The PAH MM performed comparably to the TM. Although most PCBs had recoveries > 50%, the PCB MM generally yielded lower recoveries than the TM. Average method detection limits were 0.6 mu g/kg (TM) and 1.0 mu g/kg (MM) for PCBs and 25.7 mu g/kg (TM) and 27.7 mu g/kg (MM) for PAHs. MMs described for PCB and PAH tissue samples are potentially viable alternatives to TMs, and could lead to cost savings in bioaccumulation/toxicity tests. Published by Elsevier Ltd. C1 USA, Corps Engineers, Engineer Res & Dev Ctr, EP R,Environm Risk Assessment Branch, Vicksburg, MS 39180 USA. Analyt Serv Inc, Vicksburg, MS 39182 USA. RP Jones, RP (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, EP R,Environm Risk Assessment Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM robert.p.jones@erdc.usace.army.mil NR 15 TC 8 Z9 8 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2006 VL 62 IS 11 BP 1795 EP 1805 DI 10.1016/j.chemosphere.2005.07.027 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 030VB UT WOS:000236662000005 PM 16226294 ER PT J AU Lettieri, CJ Nathan, SD Barnett, SD Ahmad, S Shorr, AF AF Lettieri, CJ Nathan, SD Barnett, SD Ahmad, S Shorr, AF TI Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis SO CHEST LA English DT Article DE catheterization; exercise test; mortality; pulmonary artery; pulmonary fibrosis; pulmonary function tests; pulmonary hypertension ID 6-MINUTE WALK TEST; AWAITING LUNG TRANSPLANTATION; INTERSTITIAL PNEUMONIA; SYSTEMIC-SCLEROSIS; PROGNOSTIC VALUE; PREDICTING SURVIVAL; DIAGNOSIS; DISEASE; MORTALITY; THERAPY AB Study objectives: The development of pulmonary arterial hypertension (PAH) can complicate many interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF). We sought to characterize the prevalence of PAH and its impact on survival in patients with advanced IPF. Design: Retrospective analysis of consecutive IPF patients undergoing pretransplantation right heart catheterization. Setting: Lung transplant and IPF referral center. Methods: PAH was defined as a mean pulmonary artery pressure (mPAP) of > 25 mm Hg. We compared demographic, spirometric, 6-min walk test (6MWT) results, and survival outcomes between those with PAH and those without PAH. Measurements and results: Seventy-nine patients were included in the study. PAH was present in 31.6% of patients (mean [+/- SD] mPAP, 29.5 +/- 3.3 vs 19.1 +/- 3.7 mm Hg, respectively). Those patients with PAH had a lower mean diffusing capacity of the lung for carbon monoxide (DLCO) (37.6 +/- 11.3% vs 31.1 +/- 10.1%, respectively; p = 0.04) and were more likely to require supplemental oxygen (66.7% vs 17.6%, respectively; p < 0.0001). Mean distance walked (143.5 +/- 65.5 vs 365.9 +/- 81.8 m, respectively; p < 0.001) and mean pulse oximetric saturation nadir (80.1 +/- 3.7% vs 88.0 +/- 3.5%, respectively; p < 0.001) during the 6MWT were also lower among those with PAH. PAH was associated with a greater risk of death during the study period (mortality rate, 60.0% vs 29.9%, respectively; odds ratio, 2.6; 95% confidence interval [CI], 2.3 to 3.1; p = 0.001). One-year mortality rates were higher in those with PAH (28.0% vs 5.5%, respectively; p = 0.002). As a predictor of mortality, PAH had a sensitivity, specificity, and accuracy of 57.1%, 79.3%, and 73.4%, respectively. There was a linear correlation between mPAP and outcomes with higher pressures associated with a greater risk of mortality (hazard ratio, 1.09; 95% CI, 1.02 to 1.16). FVC and DLCO did not predict outcomes. Conclusions: PAH is common in advanced cases of IPF and significantly impacts survival. A reduced DLCO, supplemental oxygen requirement, or poor 6-min walk performance should raise suspicion of the presence of underlying PAH. Identifying PAH might be an important adjunct in monitoring disease progression, triaging for transplantation, and guiding therapy. C1 Walter Reed Army Med Ctr, Dept Pulm & Crit Care, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. Inova Fairfax Hosp, Lung Transplant Program, Falls Church, VA USA. Washington Hosp Ctr, Dept Pulm & Crit Care Med, Washington, DC 20010 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Dept Pulm & Crit Care, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil NR 37 TC 340 Z9 354 U1 3 U2 15 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2006 VL 129 IS 3 BP 746 EP 752 DI 10.1378/chest.129.3.746 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 027GY UT WOS:000236404200037 PM 16537877 ER PT J AU Kitzmiller, R Hunt, E Sproat, SB AF Kitzmiller, R Hunt, E Sproat, SB TI Adopting best practices - "Agility" moves from software development to healthcare project management SO CIN-COMPUTERS INFORMATICS NURSING LA English DT Article DE agility; implementation; nursing informatics; project management; systems AB It is time for a change in mindset in how nurses operationalize system implementations and manage projects. Computers and systems have evolved over time from unwieldy mysterious machines of the past to ubiquitous computer use in every aspect of daily lives and work sites. Yet, disconcertingly, the process used to implement these systems has not evolved. Technology implementation does not need to be a struggle. It is time to adapt traditional plan-driven implementation methods to incorporate agile techniques. Agility is a concept borrowed from software development and is presented here because it encourages flexibility, adaptation, and continuous learning as part of the implementation process. Agility values communication and harnesses change to an advantage, which facilitates the natural evolution of an adaptable implementation process. Specific examples of agility in an implementation are described, and plan-driven implementation stages are adapted to incorporate relevant agile techniques. This comparison demonstrates how an agile approach enhances traditional implementation techniques to meet the demands of today's complex healthcare environments. C1 Walter Reed Army Inst Res, Div Regulated Act, Silver Spring, MD 20910 USA. Duke Univ Hlth Syst, Durham, NC USA. Misys Healthcare Syst, Res & Dev, Elect Med Record, Raleigh, NC USA. RP Sproat, SB (reprint author), Walter Reed Army Inst Res, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM sara.sproat@us.army.mil NR 8 TC 0 Z9 0 U1 2 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1538-2931 J9 CIN-COMPUT INFORM NU JI CIN-Comput. Inform. Nurs. PD MAR-APR PY 2006 VL 24 IS 2 BP 75 EP 82 DI 10.1097/00024665-200603000-00005 PG 8 WC Computer Science, Interdisciplinary Applications; Medical Informatics; Nursing SC Computer Science; Medical Informatics; Nursing GA 025XM UT WOS:000236300700002 PM 16554690 ER PT J AU Lentine, KL Schnitzler, MA Abbott, KC Li, LM Xiao, HL Burroughs, TE Takemoto, SK Willoughby, LM Gavard, JA Brennan, DC AF Lentine, Krista L. Schnitzler, Mark A. Abbott, Kevin C. Li, Leiming Xiao, Huiling Burroughs, Thomas E. Takemoto, Steven K. Willoughby, Lisa M. Gavard, Jeffrey A. Brennan, Daniel C. TI Incidence, predictors, and associated outcomes of atrial fibrillation after kidney transplantation SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID CONGESTIVE-HEART-FAILURE; RENAL-TRANSPLANTATION; UNITED-STATES; DIALYSIS PATIENTS; MEDICARE POPULATION; DISEASE; ARRHYTHMIAS; MORTALITY; SURVIVAL; SURGERY AB The risk for and predictors of atrial fibrillation (AF) after kidney transplantation are not well described. Registry data that were collected by the United States Renal Data System were used to investigate retrospectively new-onset AF among adult first renal allograft recipients and transplant candidates who received a transplant or were wait-listed in 1995 to 2001 with Medicare as the primary payer. AF events were ascertained from billing records, and participants were followed until loss of Medicare coverage or December 31, 2001. Cox hazards analysis was used to identify independent correlates of posttransplantation AF (adjusted hazard ratio [AHR]; 95% confidence interval [CI]) and to examine AF as an outcomes predictor. Among 31,136 eligible transplant recipients, the cumulative incidence of new-onset AF was 3.6% (95% CI 3.4 to 3.8%) and 7.3% (95% CI 7.0 to 7.6%) at 12 and 36 mo and declined below the demographics-adjusted cumulative incidence on the waiting list by approximately 17 mo. Risk factors for posttransplantation AF included older recipient age, male gender, white race, renal failure from hypertension, and coronary artery disease. Extended pretransplantation dialysis duration, posttransplantation diabetes, and graft failure were identified as potentially modifiable correlates of AF. In separate analyses, AF independently predicted death (AHR 3.2; 95% CI 2.9 to 3.6) and death-censored graft loss (AHR 1.9; 95% CI 1.6 to 2.3). As the population of renal transplant recipients grows older, the incidence and prevalence of AF among these patients will likely increase. Appropriate risk stratification may identify transplant recipients who are in need of close monitoring for and management of this adverse cardiovascular event. C1 St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63103 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 2nd Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K24-DK-002886-02, K25-DK-02916-01, DRTC-5-P60-DK20579] NR 37 TC 22 Z9 24 U1 0 U2 0 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD MAR PY 2006 VL 1 IS 2 BP 288 EP 296 DI 10.2215/CJN.00920805 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 107LH UT WOS:000242172600016 PM 17699219 ER PT J AU You, WB Zahn, CM AF You, WB Zahn, CM TI Postpartum hemorrhage: Abnormally adherent placenta, uterine inversion, and puerperal hematomas SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; BLOOD-LOSS; INTRAMYOMETRIAL INJECTION; OBSTETRIC HEMORRHAGE; RETAINED PLACENTA; CESAREAN-SECTION; INTRAVENOUS NITROGLYCERIN; CONSERVATIVE TREATMENT; METHOTREXATE TREATMENT; ULTRASOUND DIAGNOSIS C1 Uniformed Serv Univ Hlth Sci, Dept OB GYN, Bethesda, MD 20814 USA. Natl Naval Med Res Inst, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Zahn, CM (reprint author), Uniformed Serv Univ Hlth Sci, Dept OB GYN, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM czahn@usuhs.mil NR 76 TC 15 Z9 18 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2006 VL 49 IS 1 BP 184 EP 197 DI 10.1097/01.grf.0000197544.87808.9c PG 14 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 007RM UT WOS:000234987300020 PM 16456355 ER PT J AU Jackson, JL O'Malley, PG Kroenke, K AF Jackson, JL O'Malley, PG Kroenke, K TI Antidepressants and cognitive-behavioral therapy for symptom syndromes SO CNS SPECTRUMS LA English DT Review ID IRRITABLE-BOWEL-SYNDROME; CHRONIC-FATIGUE-SYNDROME; LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND CROSSOVER; FUNCTIONAL GASTROINTESTINAL DISORDERS; UNEXPLAINED PHYSICAL SYMPTOMS; TENSION-TYPE HEADACHE; FIBROMYALGIA SYNDROME AB Somatic symptoms are common in primary care and clinicians often prescribe antidepressants as adjunctive therapy. There are many possible reasons why this may work, including treating comorbid depression or anxiety, inhibition of ascending pain pathways, inhibition of prefrontal cortical areas that are responsible for "attention" to noxious stimuli, and the direct effects of the medications on the syndrome. There are good theoretical reasons why antidepressants with balanced norepinephrine and serotonin effects may be more effective than those that act predominantly on one pathway, though head-to-head comparisons are lacking. For the 11 painful syndromes review in this article, cognitive-behavioral therapy is most consistently demonstrated to be effective, with various antidepressants having more or less randomized controlled data supporting or refuting effectiveness. This article reviews the randomized controlled trial data for the use of antidepressant and cognitive-behavior therapy for 11 somatic syndromes: irritable bowel syndrome, chronic back pain, headache, fibromyalgia, chronic fatigue syndrome, tinnitus, menopausal symptoms, chronic facial pain, noncardiac chest pain, interstitial cystitis, and chronic pelvic pain. For some syndromes, the data for or against treatment effectiveness is relatively robust, for many, however, the data, one way or the other is scanty. C1 Uniformed Serv Univ Hlth Sci, Med EDP, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Med, Gen Internal Med Serv, Washington, DC 20307 USA. Indiana Univ, Div Gen Internal Med & Geriatr, Indianapolis, IN 46204 USA. Regenstrief Inst Hlth Care, Indianapolis, IN USA. RP Jackson, JL (reprint author), Uniformed Serv Univ Hlth Sci, Med EDP, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jejackson@usuhs.mil NR 133 TC 58 Z9 60 U1 4 U2 12 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1092-8529 J9 CNS SPECTRUMS JI CNS Spectr. PD MAR PY 2006 VL 11 IS 3 BP 212 EP 222 PG 11 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 027HS UT WOS:000236406600011 PM 16575378 ER PT J AU Jones, KF Peabody, AB AF Jones, KF Peabody, AB TI The application of a uniform radial ice thickness to structural sections SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE ice accretion; ice loads; power line icing; transmission lines; towers; design criteria AB Equivalent uniform radial ice thicknesses accreted from freezing rain on wires, conductors, guys and cables with round cross sections are determined for the design of ice sensitive structures from field measurements or from simulations using historical weather data. Ice thicknesses on non-round structural shapes may also be required in the design of communication towers, towers for power transmission lines, and other ice-sensitive structures. In this paper the uniform radial ice thickness on a wire is shown to be different from the uniform ice thicknesses on other structural shapes in the same icing conditions. Consistent ice thicknesses are calculated for a variety of structural shapes including angles, bars, and channels. Finally a simple method, which is used in ASCE Standard 7 Minimum Design Loads for Buildings and Other Structures, is presented for determining ice loads on arbitrary structural shapes from the uniform radial ice thickness on a wire. (c) 2005 Elsevier B.V. All rights reserved. C1 Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Jones, KF (reprint author), Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Kathleen.F.Jones@erdc.usace.army.mil; apeabody@acsalaska.net NR 6 TC 6 Z9 7 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD MAR PY 2006 VL 44 IS 2 BP 145 EP 148 DI 10.1016/j.coldregions.2005.10.002 PG 4 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 017DL UT WOS:000235674200006 ER PT J AU Ergut, A Granata, S Jordan, J Carlson, J Howard, JB Richter, H Levendis, YA AF Ergut, A Granata, S Jordan, J Carlson, J Howard, JB Richter, H Levendis, YA TI PAH formation in one-dimensional premixed fuel-rich atmospheric pressure ethylbenzene and ethyl alcohol flames SO COMBUSTION AND FLAME LA English DT Article DE ethylbenzene; ethyl alcohol; premixed flame; PAH; soot; waste incineration; kinetic modeling ID POLYCYCLIC AROMATIC-HYDROCARBONS; MUNICIPAL WASTE PLASTICS; PARTICULATE-EMISSIONS; RATE CONSTANTS; THERMAL-DECOMPOSITION; 2-STAGE COMBUSTION; POLYMERS PLASTICS; DIFFUSION FLAMES; SOOT FORMATION; KINETIC-MODEL AB This study addresses health-hazardous emissions from combustion of aromatic and oxygenated components of engine fuel blends. An investigation was conducted on the evolution of polycyclic aromatic hydrocarbons (PAH) and other pollutants (soot, CO, unburned light hydrocarbons) emitted from one-dimensional ethylbenzene and ethyl alcohol flames. The study of ethylbenzene combustion is also pertinent to that of waste polystyrene, as past work has indicated that ethylbenzene may be a surrogate for initial products of polystyrene pyrolysis. Both liquid fuels were prevaporized in nitrogen, mixed with oxygen and additional nitrogen, and upon ignition, premixed flat flames were stabilized over a burner. Temperature measurements and product sampling were conducted at various heights above the burner. Results showed that ethyl alcohol combustion generated small yields of PAH, even under the adverse fuel-rich conditions of this study (phi = 2.5). PAH mole fractions in the ethyl alcohol flame were 2-5 orders of magnitude lower than those in the ethylbenzene flame at the same location. PAH mole fractions often peaked in the postflame region and remained at relatively high levels thereafter. PAH mole fractions in premixed fuel-rich benzene, ethane, ethylene, and methane flames, published in the literature, were typically in between those found in the two flames of this study. Computations were conducted using a currently developed detailed kinetic model, allowing for the prediction of formation and depletion of major PAH and soot particles of different sizes. The computed chemical flame structures were compared to experimental data obtained in the present work. Predicted mole fractions were often close to the experimentally obtained values or, at worse, within the same order of magnitude for both fuels. Reaction pathways are discussed. (c) 2005 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 Northeastern Univ, Boston, MA 02115 USA. MIT, Cambridge, MA 02139 USA. Politecn Milan, CMIC Dept, I-20133 Milan, Italy. USA, SBCCOM Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Boston, MA 02115 USA. EM y.levendis@neu.edu NR 77 TC 53 Z9 56 U1 4 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAR PY 2006 VL 144 IS 4 BP 757 EP 772 DI 10.1016/j.combustflame.2005.07.019 PG 16 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 024JU UT WOS:000236192100009 ER PT J AU Murri, GB Schaff, JR AF Murri, GB Schaff, JR TI Fatigue life methodology for tapered hybrid composite flexbeams SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE flexbeam; polymer matrix composite; fatigue, fracture toughness; delamination AB Nonlinear-tapered flexbeam specimens from a full-size composite helicopter rotor hub flexbeam were tested under combined constant axial tension and cyclic bending loads. Two different graphite/glass hybrid configurations tested under cyclic loading failed by delamination in the tapered region. A 2-D finite element model was developed which closely approximated the flexbeam geometry, boundary conditions, and loading. The analysis results from two geometrically nonlinear finite element codes, ANSYS and ABAQUS, are presented and compared. Strain energy release rates (G) associated with simulated delamination growth in the flexbeams are presented from both codes. These results compare well with each other and suggest that the initial delamination growth from the tip of the ply-drop toward the thick region of the flexbeam is strongly mode II. The peak calculated G values were used with material characterization data to calculate fatigue life curves for comparison with test data. A curve relating maximum surface strain to number of loading cycles at delamination onset compared well with the test results. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Vehicle Technol Directorate, NASA,Langley Res Ctr, Hampton, VA 23681 USA. Sikorsky Aircraft, Stratford, CT 06601 USA. RP Murri, GB (reprint author), USA, Res Lab, Vehicle Technol Directorate, NASA,Langley Res Ctr, Hampton, VA 23681 USA. EM gretchen.b.murri@nasa.gov NR 15 TC 9 Z9 9 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD MAR PY 2006 VL 66 IS 3-4 BP 499 EP 508 DI 10.1016/j.compscitech.2005.06.010 PG 10 WC Materials Science, Composites SC Materials Science GA 008QA UT WOS:000235054600014 ER PT J AU Jensen, RE McKnight, SH AF Jensen, RE McKnight, SH TI Inorganic-organic fiber sizings for enhanced energy absorption in glass fiber-reinforced composites intended for structural applications SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE coupling agents; hybrid compounds; fiber/matrix bond; interphase; impact behavior ID EPOXY-RESIN COMPOSITES; SILANE COUPLING AGENTS; LOW-VELOCITY IMPACT; FIBER/MATRIX INTERPHASE; FABRIC COMPOSITES; MATRIX COMPOSITES; SURFACE-TREATMENT; INTERFACE REGION; STRENGTH; COATINGS AB Achieving high impact energy absorption without loss of structural performance in a glass fiber-reinforced composite can be obtained through a "materials by design" approach of the fiber matrix interphase through modification of current commercially formulated silane-based fiber sizing packages. In this paper, we document our attempt to balance the structural and impact performance of glass-reinforced composites produced using a fiber-sizing package composed of mixed silane coupling agents to vary the reactivity of the fiber with the matrix phase. Additionally, enhancement of post-failure energy absorption through increased frictional dissipation during fiber matrix pull-out was explored through control of the surface roughness of the glass fibers. A unique inorganic-organic hybrid fiber sizing formulation was successfully applied at a commercial E-glass manufacturing facility to produce rovings as well as woven fabric reinforcements. Composite materials were manufactured using these specialized fabrics and the preliminary structural and impact energy responses of these materials have been measured. Published by Elsevier Ltd. C1 USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Jensen, RE (reprint author), USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM rjensen@arl.army.mil NR 54 TC 16 Z9 17 U1 1 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD MAR PY 2006 VL 66 IS 3-4 BP 509 EP 521 DI 10.1016/j.compscitech.2005.06.004 PG 13 WC Materials Science, Composites SC Materials Science GA 008QA UT WOS:000235054600015 ER PT J AU Lavery, JE AF Lavery, JE TI Shape-preserving, first-derivative-based parametric and nonparametric cubic L-1 spline curves SO COMPUTER AIDED GEOMETRIC DESIGN LA English DT Article DE cubic spline; first derivative; first difference; interpolation; irregular data; L-1 spline; L-2 spline; nonparametric; parametric; second derivative; shape preservation; three-dimensional; two-dimensional ID PIECEWISE BICUBIC INTERPOLATION; LINEAR-PROGRAMMING PROBLEMS; MULTIQUADRIC INTERPOLATION; MULTISCALE INTERPOLATION; B-SPLINE; SPACE-CURVES; MONOTONE; ALGORITHM; APPROXIMATION; BIVARIATE AB We investigate parametric and nonparametric cubic L-1 interpolating spline curves ("L-1 splines") in two and three dimensions with the goal of achieving shape-preserving interpolation of irregular data. We introduce five types of parametric L-1 and L-2 splines calculated by minimizing expressions involving L-1 norms, L-2 norms and squares of L-2 norms of second derivatives and five types of parametric L-1 and L-2 splines calculated by minimizing analogous expressions involving first derivatives minus first differences. We compare these splines among themselves, with a simple monotonicity-based interpolant and with the interpolant of Brodlie, Fritsch and Butland. Of all of the parametric splines, first-derivative-based "interactive-component" L-1 splines preserve the shape of irregular data best. Nonparametric first-derivative-based L-1 splines are introduced and shown to preserve shape better than the previously known nonparametric second-derivative-based L-1 splines, than nonparametric first- and second-derivative-based L-2 splines and than the simple monotonicity-based and Brodlie-Fritsch-Butland interpolants. Published by Elsevier B.V. C1 USA, Res Off, Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. RP Lavery, JE (reprint author), USA, Res Off, Res Lab, Div Math, POB 12211, Res Triangle Pk, NC 27709 USA. EM john.lavery2@us.army.mil NR 45 TC 11 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8396 J9 COMPUT AIDED GEOM D JI Comput. Aided Geom. Des. PD MAR PY 2006 VL 23 IS 3 BP 276 EP 296 DI 10.1016/j.cagd.2005.11.002 PG 21 WC Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA 024YN UT WOS:000236232600003 ER PT J AU Jensen, KB Asay, KH Johnson, DA Larson, SR Waldron, BL Palazzo, AJ AF Jensen, KB Asay, KH Johnson, DA Larson, SR Waldron, BL Palazzo, AJ TI Registration of 'Bozoisky-II' Russian wildirye SO CROP SCIENCE LA English DT Article ID RYEGRASS; WILDRYE; SWIFT; AFLP C1 Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. USA Corps Engineers, ERDC, CRREL, Hanover, NH USA. RP Jensen, KB (reprint author), Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. EM kevin@cc.usu.edu NR 14 TC 3 Z9 5 U1 0 U2 0 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 USA SN 0011-183X J9 CROP SCI JI Crop Sci. PD MAR-APR PY 2006 VL 46 IS 2 BP 986 EP 987 DI 10.2135/cropsci2005.06-0163 PG 2 WC Agronomy SC Agriculture GA 021NY UT WOS:000235991100067 ER PT J AU Kim, FJ Rice, KR AF Kim, FJ Rice, KR TI Prediction of shockwave failure in patients with urinary tract stones SO CURRENT OPINION IN UROLOGY LA English DT Review DE renal calculi; shockwave lithotripsy; urolithiasis ID LOWER POLE NEPHROLITHIASIS; WAVE LITHOTRIPSY SUCCESS; MECHANICAL PERCUSSION; COMPUTERIZED-TOMOGRAPHY; INVERSION THERAPY; HOUNSFIELD UNITS; CALCULI; FRAGMENTATION; TRIAL; GENERATIONS AB Purpose of review To evaluate recent developments in predicting the failure of shockwave lithotripsy when treating patients with urinary tract stones. Recent findings Although the features of patients with stones, as well as of the stones themselves, associated with refractoriness to shockwave lithotripsy are fairly well defined, refining the preoperative detection of these traits and optimizing the efficacy of shockwave lithotripsy are still under investigation. Several studies have recently focused on improving the radiological appraisal of stone size and composition through the use of axial computed tomography and reconstruction software. Other investigators have researched techniques to increase the efficacy of the technology underlying shockwave lithotripsy, such as varying the shockwave delivery rate and method. Summary Investigators have demonstrated different factors and predictors that affect shockwave lithotripsy for stone disease. Continued research will better define patient selection and the role of shockwave lithotripsy in the treatment of urolithiasis. C1 Denver Hlth Med Ctr, Dept Surg, Div Urol, Denver, CO USA. Univ Colorado, Hlth Sci Ctr, Denver, CO 80202 USA. Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. RP Kim, FJ (reprint author), Denver Hlth Med Ctr, Dept Surg, Div Urol, Denver, CO USA. EM fernando.kim@uchsc.edu RI Kim, Fernando/L-6319-2013 OI Kim, Fernando/0000-0002-6773-5891 NR 40 TC 15 Z9 15 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0963-0643 J9 CURR OPIN UROL JI Curr. Opin. Urol. PD MAR PY 2006 VL 16 IS 2 BP 88 EP 92 DI 10.1097/01.mou.0000193373.22318.68 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 026CE UT WOS:000236313500009 PM 16479210 ER PT J AU Yen, J Fan, XC Sun, S Hanratty, T Dumer, J AF Yen, J Fan, XC Sun, S Hanratty, T Dumer, J TI Agents with shared mental models for enhancing team decision makings SO DECISION SUPPORT SYSTEMS LA English DT Article DE homeland security; information overload; agent teamwork; team decision making ID SYSTEMS; ARCHITECTURE; FRAMEWORK; IMPACT AB Proactive information sharing is a challenging issue faced by intelligence agencies in effectively making critical decisions under time pressure in areas related to homeland security. Motivated by psychological studies on human teams, a team-oriented agent architecture, Collaborative Agents for Simulating Teamwork (CAST), was implemented to allow agents in a team to anticipate the information needs of teammates and help them with their information needs proactively and effectively. In this paper, we extend CAST with a decision-making module. Through two sets of experiments in a simulated battlefield, we evaluate the effectiveness of the decision-theoretic proactive communication strategy in improving team performance, and the effectiveness of information fusion as an approach to alleviating the information overload problem faced by distributed decision makers. (c) 2004 Elsevier B.V All rights reserved. C1 Penn State Univ, Sch Informat Sci & Technol, University Pk, PA 16802 USA. US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Penn State Univ, Sch Informat Sci & Technol, University Pk, PA 16802 USA. EM jyen@ist.psu.edu NR 44 TC 39 Z9 40 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9236 EI 1873-5797 J9 DECIS SUPPORT SYST JI Decis. Support Syst. PD MAR PY 2006 VL 41 IS 3 BP 634 EP 653 DI 10.1016/j.dss.2004.06.008 PG 20 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Operations Research & Management Science SC Computer Science; Operations Research & Management Science GA 021WI UT WOS:000236016200007 ER PT J AU Adams, BD Bonzani, TA Hunter, CJ AF Adams, BD Bonzani, TA Hunter, CJ TI The anion gap does not accurately screen for lactic acidosis in emergency department patients SO EMERGENCY MEDICINE JOURNAL LA English DT Article ID OXYGEN-DERIVED VARIABLES; CRITICALLY-ILL PATIENTS; BLOOD LACTATE LEVELS; SERUM LACTATE; BASE-DEFICIT; SEPTIC SHOCK; TRAUMA RESUSCITATION; EXCESS; MORTALITY; CARE AB Introduction: Lactic acidosis portends a poor prognosis in trauma, sepsis, and other shock states and is useful for triaging and resuscitating emergency department ( ED) patients. The authors sought to determine whether the AG is a reliable screen for lactic acidosis when applied specifically in the ED setting. Methods: The authors performed a retrospective cohort study over a seven month period. Subjects were all ED patients that had a serum lactate obtained. Sensitivity analyses of the AG for detecting presence of lactic acidosis were calculated for the traditional AG normal value ( AG > 12) and for the lower AG normal value when using newer ion selective electrode assays ( AG,6). Results: Serum lactate levels were ordered in the ED on 440 occasions. 137 samples were excluded by protocol. Using an AG cutoff of 12, the sensitivity for detecting lactic acidosis was 58.2%, specificity was 81.0%, and the negative predictive value was 89.7%. Using the AG cutoff of 6, the sensitivity was 93.2%, the specificity was 17.3%, and the negative predictive value was 91.8%. Conclusions: The traditional definition of AG > 12 was insensitive for the presence of lactic acidosis. Using the revised AG of > 6 is more sensitive but non- specific for lactic acidosis. The authors conclude that employing the AG as a screen for LA may be inappropriate in ED patients. Instead, they recommend ordering a serum lactate immediately upon suspicion of a shock state. A prospective study to confirm these findings is needed. C1 USA, San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Brooke Army Med Ctr, San Antonio, TX 78234 USA. RP Adams, BD (reprint author), USA, San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Brooke Army Med Ctr, San Antonio, TX 78234 USA. NR 26 TC 14 Z9 14 U1 1 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1472-0205 J9 EMERG MED J JI Emerg. Med. J. PD MAR PY 2006 VL 23 IS 3 BP 179 EP 182 DI 10.1136/emj.2005.026096 PG 4 WC Emergency Medicine SC Emergency Medicine GA 023ML UT WOS:000236130700004 PM 16498152 ER PT J AU Duprey, ZH Steurer, FJ Rooney, JA Kirchhoff, LV Jackson, JE Rowton, ED Schantz, PM AF Duprey, ZH Steurer, FJ Rooney, JA Kirchhoff, LV Jackson, JE Rowton, ED Schantz, PM TI Canine visceral leishmaniasis, United States and Canada, 2000-2003 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NORTH-AMERICA; SAND FLIES; TRANSMISSION; DOGS; SPECIFICITY; SENSITIVITY; INFANTUM; ANTIBODY; BLOOD; AREA AB Visceral leishmaniasis, caused by protozoa of the genus Leishmania donovani complex, is a vectorborne zoonotic infection that infects humans, dogs, and other mammals. In 2000, this infection was implicated as causing high rates of illness and death among foxhounds in a kennel,in New York. A serosurvey of > 12,000 foxhounds and other canids and 185 persons in 35 states and 4 Canadian provinces was performed to determine geographic extent, prevalence, host range, and modes of transmission within foxhounds, other dogs, and wild canids and to assess possible infections in humans. Foxhounds infected with Leishmania spp. were found in 18 states and 2 Canadian provinces. No evidence of infection was found in humans. The infection in North America appears to be widespread in foxhounds and limited to clog-to-dog mechanisms of transmission; however, if the organism becomes adapted for vector transmission by indigenous phlebotomines, the probability of human exposure will be greatly increased. C1 Ctr Dis Control & Prevent, Div Parasit Dis, CCID, Atlanta, GA 30341 USA. Univ Iowa, Iowa City, IA 52242 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Schantz, PM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, CCID, Mailstop F22,4770 Buford Hwy, Atlanta, GA 30341 USA. EM pschantz@cdc.gov RI Rowton, Edgar/A-1975-2011; Rowton, Edgar/A-4474-2012 OI Rowton, Edgar/0000-0002-1979-1485; NR 20 TC 103 Z9 105 U1 0 U2 5 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2006 VL 12 IS 3 BP 440 EP 446 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 020PP UT WOS:000235922300012 PM 16704782 ER PT J AU Freese, CE Baratta, FI AF Freese, CE Baratta, FI TI Single edge-crack stress intensity factor solutions SO ENGINEERING FRACTURE MECHANICS LA English DT Article DE linear fracture mechanics; stress intensity factors; single edge-cracked geometries; boundary collocation technique; weight function analysis AB Weight function arguments and a boundary collocation technique are used to re-examine the stress intensity factor solutions to several classic two-dimensional linear elastic single edge-crack configurations. Limits to applicability and the solutions to the three and four-point bend, pure bending, eccentrically loaded tension, and other boundary condition problems are extracted from the solution to the uniformly loaded single edge-cracked configuration. A simple representation of the asymptotic behavior is proposed and a common expression that captures the full range of crack length to specimen width ratio is presented. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Mat Directorate, Watertown, MA 02472 USA. RP ABCEF Consulting, 6 Springdale Rd, Lexington, MA 02421 USA. EM cefreese@cs.com NR 12 TC 14 Z9 14 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 EI 1873-7315 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD MAR PY 2006 VL 73 IS 5 BP 616 EP 625 DI 10.1016/j.engfracmech.2005.09.003 PG 10 WC Mechanics SC Mechanics GA 012AV UT WOS:000235311500006 ER PT J AU Kuperman, RG Checkai, RT Simini, M Phillips, CI Speicher, JA Barclift, DJ AF Kuperman, RG Checkai, RT Simini, M Phillips, CI Speicher, JA Barclift, DJ TI Toxicity benchmarks for antimony, barium, and beryllium determined using reproduction endpoints for Folsomia candida, Eisenia fetida, and Enchytraeus crypticus SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT Symposium on Risk Assessment of Metals in Soils CY APR 18-22, 2004 CL Prague, CZECH REPUBLIC DE antimony; barium; beryllium; soil invertebrate toxicity; ecological soil screening levels ID HETEROCYCLIC EXPLOSIVES RDX; SOIL SOLUTION; OLIGOCHAETA; EARTHWORM; COLLEMBOLA; COPPER; SURVIVAL; ANDREI; TESTS; HMX AB The U.S. Environmental Protection Agency is developing ecological soil screening levels (Eco-SSLs) for the ecological risk assessment of contaminants at Superfund sites. The Eco-SSLs for several soil contaminants have been developed from toxicity benchmarks for soil invertebrates in the existing literature. Insufficient information to generate Eco-SSLs for Sb, Ba, and Be necessitated toxicity testing to fill the data gaps. We used standardized toxicity tests with the earthworm Eisenia fetida, enchytraeid Enchytraeus crypticus, and collembolan Folsomia candida in the present study. These tests were selected on the basis of their ability to measure chemical toxicity to ecologically relevant test species during chronic assays and their inclusion of at least one reproduction component among the measurement endpoints. Tests were conducted in Sassafras Sandy Loam soil, which supports relatively high bioavailability of metals. Weathering and aging procedures for metals in amended soil were incorporated into these studies to better reflect exposure conditions in the field. The relative toxicity of metals to the soil invertebrates tested was Be > Sb > Ba based on the median effective concentration values for reproduction. These studies produced toxicological data that can contribute to the development of Eco-SSLs for Sb, Ba, and Be for soil invertebrates. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. USN, Facil Engn Command, Engn Field Act NE, Lester, PA 19113 USA. RP Kuperman, RG (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM roman.kuperman@us.army.mil RI Kuperman, Roman/D-4297-2009 NR 49 TC 25 Z9 30 U1 4 U2 29 PU SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2006 VL 25 IS 3 BP 754 EP 762 DI 10.1897/04-545R.1 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 017NP UT WOS:000235700600016 PM 16566160 ER PT J AU Inouye, LS Jones, RP Bednar, AJ AF Inouye, LS Jones, RP Bednar, AJ TI Tungsten effects on survival, growth, and reproduction in the earthworm, Eisenia fetida SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT Symposium on Risk Assessment of Metals in Soils CY APR 18-22, 2004 CL Prague, CZECH REPUBLIC DE tungsten; toxicity; soil; reproduction; earthworm ID LEAD; MOLYBDENUM; SAVIGNY; COPPER; SOIL AB To provide basic toxicity data for formulating risk characterization benchmarks, the effects of tungsten on survival, growth, and reproduction were investigated in the earthworm Eiseniafetida. Parallel studies with lead as a reference toxicant also were conducted. Although sodium tungstate (Na2WO4) was less acutely toxic than lead nitrate (Pb(NO3)(2)) in 14-d spiked field soil acute toxicity assays (lethal concentrations for 50% of organisms: W, 6,250 mg/kg; Ph, 2,490 mg/kg), tungstate completely inhibited reproduction in 28- and 56-d assays at all tested tungsten concentrations (>= 704 mg/kg). By comparison, cocoon production was not significantly reduced for lead concentrations until concentrations reached 766 mg/kg, and cocoon production was still observed at the highest concentration tested (1,650 mg/kg). These data indicate that tungsten is a reproductive toxicant for earthworms and that, by comparison, its sublethal toxicity is greater than that of lead. Toxicity data for other soil invertebrate species are required to fully establish benchmark levels/ecological soil screening levels for tungsten. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Inouye, LS (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM inouyel@wes.army.mil NR 17 TC 18 Z9 18 U1 2 U2 12 PU SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2006 VL 25 IS 3 BP 763 EP 768 DI 10.1897/04-578R.1 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 017NP UT WOS:000235700600017 PM 16566161 ER PT J AU Barry, KM Thieke, RJ Mehta, AJ AF Barry, KM Thieke, RJ Mehta, AJ TI Quasi-hydrodynamic lubrication effect of clay particles on sand grain erosion SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE bed stability; erosion control; coastal waters; estuaries; sediment mixtures; clay particles; benthic boundary layer AB Minor changes in the mass physical properties of submerged sand beds can have significant consequences relative to bed stability against erosion. To examine the effect of small amounts of clay-sized particles in bed pore water on the critical shear stress tau(c), for the erosion of sand grains, flume experiments were carried out on the erosion of quartz sand beds impregnated with clay particles. Starting with no clay, as the clay mass fraction Psi was increased, tau(c) was found to decrease below the value for pure sand tau(co) at Psi = Psi(m), then reverted to tau(c) at Psi = Psi(r) and continued to increase above tau(co) as Psi was increased further. Post-experi mental analysis suggests that Psi(r) is the pore space-filling fine sediment fraction above which sand erosion is significantly influenced by clay. In the range of Psi >= Psi(m), slider-bearing type lubrication due to the viscosity of the clay-laden interstitial fluid appears to govern the dependence of tau(c) on Psi, mimicking Petroff's law of thick-film lubrication. When Psi < Psi(m), as Psi decreases lubrication is increasingly curtailed by grain asperities, and tau(c) reverts ultimately tau(co) at Psi = 0. An equation relating tau(c) to Psi is proposed in analogy with the quasi-hydrodynamic Stribeck function for lubrication. The observed effect of clay particles appears to be significant enough to require its consideration in coastal and estuarine sediment transport modeling. It may also be a factor in the estimation of bed stability when biological activity in the benthic boundary layer introduces fine particles in clean sand beds. (c) 2005 Elsevier Ltd. All rights jeserved. C1 Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. USA, Coastal & Hydraul Lab, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Mehta, AJ (reprint author), Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. EM mehta@coastal.ufl.edu NR 20 TC 4 Z9 4 U1 0 U2 4 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD MAR PY 2006 VL 67 IS 1-2 BP 161 EP 169 DI 10.1016/j.ecss.2005.11.009 PG 9 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 019RK UT WOS:000235854200013 ER PT J AU Kraemer, WJ Kim, SK Bush, JA Nindl, BC Volek, JS Spiering, BA Hatfield, DL Fragala, MS Putukian, M Sebastianelli, WJ AF Kraemer, WJ Kim, SK Bush, JA Nindl, BC Volek, JS Spiering, BA Hatfield, DL Fragala, MS Putukian, M Sebastianelli, WJ TI Influence of the menstrual cycle on proenkephalin peptide F responses to maximal cycle exercise SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE opioid peptides; pre-exercise arousal; analgesia; adrenal medulla ID GRADED-EXERCISE; CELL RESPONSES; PLASMA; CATECHOLAMINE; LACTATE; BLOOD AB Proenkephalin peptide F [107-140] is an enkephalin-containing peptide found predominantly within the adrenal medulla and is co-packaged with epinephrine within adrenal medullary chromaffin granules. Peptide F has been shown to have the classic opioid analgesia effects along with immune cell interactions. This is only the second peptide F study in women, and in it we compare the responses of peptide F to a maximal cycle exercise test and recovery values over the follicular and luteal phases of the menstrual cycle. Eight untrained (directly documented in this study) women who were eumenorrheic performed a progressive maximal exercise test to volitional exhaustion on a cycle ergometer, once during the follicular phase, and once during the luteal phases of the menstrual cycle. Blood was obtained pre-exercise, immediately post-exercise and at 0, 15, and 30 min into recovery. Typical exercise changes in response to the cycle tests were observed with blood lactate increases that remained elevated 30 min into recovery. No significant exercise-induced elevations were observed for peptide F concentrations with exercise nor were any differences observed between the two menstrual phases. Thus, the effects of the menstrual cycle on peptide F concentrations appear to be minimal under the conditions of this investigation. With high concentrations of peptide F observed at rest (approx. 0.2-0.3 pmol ml(-1)) pre-exercise arousal mechanisms may have obviated any exercise-induced response. In addition, inhibition via elevated epinephrine may have inhibited any post-exercise increases and finally adrenal medullary capacity for circulatory concentrations of peptide F may have been reached in such untrained women. Pre-exercise arousal mechanisms potentially related to analgesia may also be involved to prepare untrained women for the stress of maximal exercise. C1 Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. Penn State Univ, Ctr Sports Med, University Pk, PA 16802 USA. USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. Univ Houston, Lab Integrated Physiol, Dept Hlth & Human Performance, Houston, TX 77204 USA. Princeton Univ, Princeton, NJ 08544 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. EM William.Kraemer@uconn.edu NR 22 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD MAR PY 2006 VL 96 IS 5 BP 581 EP 586 DI 10.1007/s00421-005-0114-4 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 021QX UT WOS:000236000900014 PM 16408233 ER PT J AU Hsiao, CH Li, W Lou, TF Baliga, BS Pace, BS AF Hsiao, CH Li, W Lou, TF Baliga, BS Pace, BS TI Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species SO EXPERIMENTAL HEMATOLOGY LA English DT Article ID ACTIVATED PROTEIN-KINASE; GLOBIN GENE-EXPRESSION; SICKLE-CELL-ANEMIA; GAMMA-GLOBIN; ERYTHROID PROGENITORS; DEPENDENT ACTIVATION; REDOX REGULATION; HYPOXIA; HYDROXYUREA; METHYLATION AB Objective. Several compounds, including butyrate and trichostatin A, have been shown to activate gamma-gene expression via p38 mitogen-activated protein kinase (MAPK) signaling. In eukaryotic cells, reactive oxygen species (ROS) act as signaling molecules to mediate phospborylation of tyrosine kinases such as p38 MAPK to regulate gene expression. Therefore, we determined the role of the reactive oxygen species hydrogen peroxide (H2O2) in drug-mediated fetal hemoglobin (HbF) induction. Methods. H2O2 levels were measured using 2',7'-dichlorofluorescein-diacetate in K562 cells after drug treatments. To confirm a role for H2O2 in HbF induction, studies were completed with the mitochondrial respiratory chain inhibitor myxothiazole, which prevents ROS generation. The ability of myxothiazole to block gamma-globin mRNA accumulation and HbF induction was measured in K562 cells and burst-forming unit-erythroid colonies respectively using quantitative real-time PCR and alkaline denaturation. Results. Butyrate and trichostastin A stimulated p38 MAPK phosphorylation via a H2O2-dependent mechanism. Pretreatment with myxothiazole to inhibit ROS formation or SB203580 to impede p38 MAPK signaling attenuated gamma-gene activation in K562 cells and HbF induction in erythroid progenitors. However, myxothiazole had no effect on the ability of hydroxyurea to induce HbF. Conclusion. The findings presented herein support a ROS-p38 MAPK cell signaling mechanism for HbF induction by butyrate and trichostatin A. (c) 2006 International Society for Experimental Hematology. Published by Elsevier Inc. C1 Univ Texas, Dept Mol & Cell Biol, Richardson, TX 75083 USA. Univ S Alabama, Med Ctr, Dept Pediat, USA, Mobile, AL USA. RP Pace, BS (reprint author), Univ Texas, Dept Mol & Cell Biol, POB 830688, Richardson, TX 75083 USA. EM bpace@utdallas.edu NR 51 TC 22 Z9 22 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD MAR PY 2006 VL 34 IS 3 BP 264 EP 273 DI 10.1016/j.exphem.2005.12.009 PG 10 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA 033HS UT WOS:000236838400002 PM 16543060 ER PT J AU Byrd, W Cassels, FJ AF Byrd, W Cassels, FJ TI Long-term systemic and mucosal antibody responses measured in BALB/c mice following intranasal challenge with viable enterotoxigenic Escherichia coli SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE enterotoxigenic Escherichia coli (ETEC); colonization factor (CS3); intranasal ID NASAL LYMPHOID-TISSUE; COLONIZATION FACTORS; DIARRHEAL DISEASE; SECRETING CELLS; MODEL; IMMUNIZATION; PATHOGENESIS; STRAINS; CS6 AB The immunogenicity induced in BALB/c mice following intranasal challenge with a viable nonlethal dose (1.2 x 10(8) CFU) of enterotoxigenic Escherichia coli (ETEC) strain E23477A (O139:H28:CS1:CS3:LT+:ST+) was studied over a 140-day period. Serum IgG and IgM antibodies against coli surface antigen 3 (CS3), O139 lipopolysaccharide and heat-labile enterotoxin were measured by day 14 and remained at elevated levels out to day 140. The serum IgG response to the somatic antigens (CS3 and O139 lipopolysaccharide) was significantly greater (P < 0.05) than the IgG response to heat-labile enterotoxin, and the serum IgG response to CS3 was significantly greater (P < 0.05) than the IgG response to O139 lipopolysaccharide. The predominant serum IgG subclasses to CS3 were IgG1 and IgG2a, and they were significantly greater (P < 0.05) than IgG2b and IgG3. The predominant serum IgG subclass response to O139 lipopolysaccharide was initially IgG3 until day 56, after which IgG1 was predominant. The serum subclass response to CS3 indicated a mixed T helper 1/2 (Th1/Th2) profile, whereas the response to O139 lipopolysaccharide was primarily that of a Th2-type, at least over time. Fecal IgG and IgA responses to CS3 and O139 lipopolysaccharide were detected by day 14 and were measured out to day 140, with the CS3 fecal antibody responses being significantly greater (P < 0.05) than the O139 lipopolysaccharide and heat-labile enterotoxin fecal antibody responses. The aim of this study is the development of the intranasal mouse model that can aid in better understanding the immunopathology of ETEC infection and in screening of vaccine candidates prior to volunteer trials. C1 Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD USA. RP Byrd, W (reprint author), 20144 Timber Oak Lane, Germantown, MD 20874 USA. EM dagmarbyrd@comcast.net NR 26 TC 2 Z9 2 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD MAR PY 2006 VL 46 IS 2 BP 262 EP 268 DI 10.1111/j.1574-695X.2005.00039.x PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 012IH UT WOS:000235331300014 PM 16487308 ER PT J AU Rayburn, Y AF Rayburn, Y TI The last exit from Iraq SO FOREIGN AFFAIRS LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD MAR-APR PY 2006 VL 85 IS 2 BP 29 EP 40 PG 12 WC International Relations SC International Relations GA 016VY UT WOS:000235650200003 ER PT J AU Haigh, MM Pfau, M Danesi, J Tallmon, R Bunko, T Nyberg, S Thompson, B Babin, C Cardella, S Mink, M Temple, B AF Haigh, MM Pfau, M Danesi, J Tallmon, R Bunko, T Nyberg, S Thompson, B Babin, C Cardella, S Mink, M Temple, B TI A comparison of embedded and nonembedded print coverage of the US invasion and occupation of Iraq SO HARVARD INTERNATIONAL JOURNAL OF PRESS-POLITICS LA English DT Editorial Material DE embedded; nonembedded; print media coverage; war in Iraq ID CREDIBILITY; IMPACT; SELF AB This study examines the impact of embedded versus nonembedded (unilateral) news coverage during the U.S. invasion and occupation of Iraq. A content analysis was conducted of the Washington Post, New York Times, Los Angeles Times, and Chicago Tribune news coverage of the invasion and occupation examining whether embedded and nonembedded new reports were different and, if so, how. News reports were examined for differences in tone toward the military, trust in the military, framing, and authoritativeness. The results of the study revealed significant differences in overall tone toward the military, trust in military personnel, framing, and authoritativeness between embedded and nonembedded articles. C1 Univ Oklahoma, Dept Commun, Norman, OK 73019 USA. Univ Oklahoma, Dept Def Joint Course Commun, Norman, OK 73019 USA. FORSCOM Publ Affairs, Ft McPherson, GA USA. DINFOS, Ft Meada, MD USA. USN, Air Stn Joint Reserve Base, New Orleans, LA USA. Air Force News, Marine Corps Detachment B, Iwakuni, Japan. Marine Corps Base, Camp Lejeune, NC USA. RP Haigh, MM (reprint author), Univ Oklahoma, Dept Commun, 610 Elm Ave, Norman, OK 73019 USA. EM mmhaigh@ou.edu NR 37 TC 9 Z9 9 U1 1 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1081-180X J9 HARV INT J PRESS-POL JI Harv. Int. J. Press-Polit. PD SPR PY 2006 VL 11 IS 2 BP 139 EP 153 DI 10.1177/1081180X05286041 PG 15 WC Communication; Political Science SC Communication; Government & Law GA 027BF UT WOS:000236388000007 ER PT J AU Roach, W Thomas, R Buffington, G Polhamus, G Notabartolo, J DiCarlo, C Stockton, K Stolarski, D Schuster, K Carothers, V Rockwell, B Cam, C AF Roach, W Thomas, R Buffington, G Polhamus, G Notabartolo, J DiCarlo, C Stockton, K Stolarski, D Schuster, K Carothers, V Rockwell, B Cam, C TI Simultaneous exposure using 532 and 860 nm lasers for visible lesion thresholds in the rhesus retina SO HEALTH PHYSICS LA English DT Article DE analysis; statistical; laboratory animals; lasers; maximum permissible exposures ID DAMAGE; RADIATION; INJURY; WAVELENGTH AB The growth of commercially available, simultaneous multi-wavelength laser systems has increased the likelihood of possible ocular hazard. For example, many systems utilize frequency multiplying methods to produce combinations of visible, near-infrared, and ultraviolet wavelengths. Unfortunately, very little data exists to substantiate the current methods for estimating hazards from simultaneous lasing. To properly assess the retinal hazards from these wavelengths, the retinal effects of 10-s laser irradiation from 532 and 860 nm were determined in non-human primates for four different relative dosage combinations of these wavelengths. This pair of wavelengths represents the typical problem of a visible-wavelength laser combined with an in-band, infrared wavelength that is not as well focused at the retina-a situation difficult to address. To add confidence to the experimental results obtained, a theoretical thermodynamic model was developed to predict the minimal damage threshold for simultaneous wavelengths at 1 h post exposure. The new model calculations and the data obtained are compared with results from one currently accepted method of predicting relative exposure limits from multi-wavelength systems. In addition, the current ANSI-Z136-2000 standard was used to compute the combined MPEs for comparison with measured visible lesion thresholds. A total of 12 eyes were exposed using four different ratios of power levels (532/860 power rations) to determine the contribution to the damage levels from each wavelength. The experimental data were analyzed using probit analysis at both 1-h and 24-h post exposure to determine the minimum-visible-lesion (MVL) thresholds at ED50 values, and these thresholds at 24 h varied from 5.6 mW to 17 mW total intraocular power. C1 USAF, Res Lab, Opt Radiat Branch, Brooks AFB, TX 78235 USA. Ft Hays State Univ, Dept Phys, Hays, KS 67601 USA. USA, Med Res Detachment, Walter Reed Army Inst Res, Brooks AFB, TX 78235 USA. Northrop Grumman, San Antonio, TX 78228 USA. RP Roach, W (reprint author), USAF, Res Lab, Opt Radiat Branch, Brooks AFB, TX 78235 USA. EM william.roach@brooks.af.mil NR 29 TC 3 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2006 VL 90 IS 3 BP 241 EP 249 DI 10.1097/01.HP.0000180773.07672.af PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 016DG UT WOS:000235600300006 PM 16505621 ER PT J AU Van Winkle, LJ Tesch, JK Shah, A Campione, AL AF Van Winkle, LJ Tesch, JK Shah, A Campione, AL TI System B-0,B-+ amino acid transport regulates the penetration stage of blastocyst implantation with possible long-term developmental consequences through adulthood SO HUMAN REPRODUCTION UPDATE LA English DT Review DE amino acid transport systems; embryo implantation; human development; metabolic syndrome; small for gestational age ID PREIMPLANTATION MOUSE CONCEPTUSES; P70 S6 KINASE; INTRAUTERINE GROWTH RESTRICTION; LEUKEMIA INHIBITORY FACTOR; DELAYED IMPLANTING MICE; FOR-GESTATIONAL-AGE; INDOLEAMINE 2,3-DIOXYGENASE; SKELETAL-MUSCLE; FETAL-GROWTH; EMBRYO IMPLANTATION AB Amino acid transport system B-0,B-+ was first characterized in detail in mouse blastocysts over two decades ago. Since then, this system has been shown to be involved in a wide array of developmental processes from blastocyst implantation in the uterus to adult obesity. Leucine uptake through system B-0,B-+ in blastocysts triggers mammalian target of rapamycin (mTOR) signalling. This signalling pathway selectively regulates development of trophoblast motility and the onset of the penetration stage of blastocyst implantation about 20 h later. Meanwhile, system B-0,B-+ becomes inactive in blastocysts a few hours before implantation in vivo. System B-0,B-+ can, however, be activated in preimplantation blastocysts by physical stimuli. The onset of trophoblast motility should provide the physiological physical stimulus activating system B-0,B-+ in blastocysts in vivo. Activation of system B-0,B-+ when trophoblast cells begin to penetrate the uterine epithelium would cause it to accumulate its preferred substrates, which include tryptophan, from uterine secretions. A low tryptophan concentration in external secretions next to trophoblast cells inhibits T-cell proliferation and rejection of the conceptus. Suboptimal system B-0,B-+ regulation of these developmental processes likely influences placentation and subsequent embryo nutrition, birth weight and risk of developing metabolic syndrome and obesity. C1 Midwestern Univ, Dept Biochem, Downers Grove, IL 60515 USA. Midwestern Univ, Dept Obstet & Gynecol, Downers Grove, IL 60515 USA. Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. RP Van Winkle, LJ (reprint author), Midwestern Univ, Dept Biochem, 555 31st St, Downers Grove, IL 60515 USA. EM lvanwi@midwestern.edu NR 121 TC 18 Z9 18 U1 1 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1355-4786 J9 HUM REPROD UPDATE JI Hum. Reprod. Update PD MAR-APR PY 2006 VL 12 IS 2 BP 145 EP 157 DI 10.1093/humupd/dmi044 PG 13 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 011PL UT WOS:000235280500005 PM 16251251 ER PT J AU Ni, ZC Shi, YQ Ansari, N Su, W AF Ni, ZC Shi, YQ Ansari, N Su, W TI Reversible data hiding SO IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY LA English DT Article DE histogram modification; reversible (lossless) data hiding; watermarking ID WAVELET TRANSFORMS; WATERMARKING AB A novel reversible data hiding algorithm, which can recover the original image without any distortion from the marked image after the hidden data have been extracted, is presented in this paper. This algorithm utilizes the zero or the minimum points of the histogram of an image and slightly modifies the pixel grayscale values to embed data into the image. It can embed more data than many of the existing reversible data hiding algorithms. It is proved analytically and shown experimentally that the peak signal-to-noise ratio (PSNR) of the marked image generated by this method versus the original image is guaranteed to be above 48 dB. This lower bound of PSNR is much higher than that of all reversible data hiding techniques reported in the literature. The computational complexity of our proposed technique is low and the execution time is short. The algorithm has been successfully applied to a wide range of images, including commonly used images, medical images, texture images, aerial images and all of the 1096 images in CorelDraw database. Experimental results and performance comparison with other reversible data hiding schemes are presented to demonstrate the validity of the proposed algorithm. C1 New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. USA, Commun Elect RD&E Ctr, Intelligence & Informat Warfare Directorate, Ft Monmouth, NJ 07703 USA. RP Ni, ZC (reprint author), WorldGate Commun Inc, Trevose, PA 19053 USA. EM zn2@njit.edu; nirwan.ansari@njit.edu; WEI.SU@US.ARMY.MIL NR 20 TC 712 Z9 811 U1 8 U2 47 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1051-8215 J9 IEEE T CIRC SYST VID JI IEEE Trans. Circuits Syst. Video Technol. PD MAR PY 2006 VL 16 IS 3 BP 354 EP 362 DI 10.1109/TCSVT.2006.869964 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 028GJ UT WOS:000236474700003 ER PT J AU Katsis, DC vanWyk, JD AF Katsis, DC vanWyk, JD TI Thermal, mechanical, and electrical study of voiding in the solder die-attach of power MOSFETs SO IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TECHNOLOGIES LA English DT Article DE die-attach; hot-spots; power electronics; thermal degradation ID DEVICES AB Large area die-attach defects have been shown to increase the thermal impedance of power semiconductor devices. The changes in thermal performance are simulated and measured in the silicon die using one-, two-, and three-dimensional methods. Experimental measurements for devices with various levels of die-attach void growth are presented. This data is then correlated with finite element thermal modeling to improve the estimate of peak die temperature for voided semiconductor devices. The results present a complete understanding of the heat flow within the voided semiconductor package with an estimate of its impact on performance over its lifetime. C1 USA, Res Lab, AMSRL, SE,DP, Adelphi, MD 20742 USA. Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Ctr Power Elect Syst, Blacksburg, VA 24061 USA. RP Katsis, DC (reprint author), USA, Res Lab, AMSRL, SE,DP, Adelphi, MD 20742 USA. EM dkatsis@arl.army.mil NR 19 TC 15 Z9 15 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1521-3331 J9 IEEE T COMPON PACK T JI IEEE Trans. Compon. Packaging Technol. PD MAR PY 2006 VL 29 IS 1 BP 127 EP 136 DI 10.1109/TCAPT.2006 PG 10 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 020HW UT WOS:000235900500016 ER PT J AU Franaszek, M Summers, RM Pickhardt, PJ Choi, JR AF Franaszek, M Summers, RM Pickhardt, PJ Choi, JR TI Hybrid segmentation of colon filled with air and opacified fluid for CT colonography SO IEEE TRANSACTIONS ON MEDICAL IMAGING LA English DT Article DE colon segmentation; CT colonography; fuzzy connectedness; zero level set ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; VIRTUAL COLONOSCOPY; COLORECTAL POLYPS AB Reliable segmentation of the colon is a requirement for three-dimensional visualization programs and automatic detection of polyps on computed tomography (CT) colonography. There is an evolving clinical consensus that giving patients positive oral contrast to tag out remnants of stool and residual fluids is mandatory. The presence of positive oral contrast in the colon adds an additional challenge for colonic segmentation but ultimately is beneficial to the patient because the enhanced fluid helps reveal polyps in otherwise hidden areas. Therefore, we developed a new segmentation procedure which can handle both air- and fluid-filled parts of the colon. The procedure organizes individual air- and fluid-filled regions into a graph that enables identification and removal of undesired leakage outside the colon. In addition, the procedure provides a risk assessment of possible leakage to assist the user prior to the tedious task of visual verification. The proposed hybrid algorithm uses modified region growing, fuzzy connectedness and level set segmentation. We tested our algorithm on 160 CT coloringraphy scans containing 183 known polyps. All 183 polyps were in segmented regions. In addition, visual inspection of 24 CT colonography scans demonstrated good performance of our procedure: the reconstructed colonic wall appeared smooth even at the interface between air and fluid and there were no leaked regions. C1 Warren Grant Magnuson Clin Ctr, Dept Diagnost Radiol, Natl Inst Hlth, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Natl Naval Med Res Inst, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Franaszek, M (reprint author), Warren Grant Magnuson Clin Ctr, Dept Diagnost Radiol, Natl Inst Hlth, Bethesda, MD 20892 USA. EM mfranaszek@cc.nih.gov FU Intramural NIH HHS NR 26 TC 56 Z9 59 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0278-0062 J9 IEEE T MED IMAGING JI IEEE Trans. Med. Imaging PD MAR PY 2006 VL 25 IS 3 BP 358 EP 368 DI 10.1109/TMI.2005.863836 PG 11 WC Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Engineering; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA 018SB UT WOS:000235784000010 PM 16524091 ER PT J AU Hoyos, S Sadler, BM Arce, GR AF Hoyos, S Sadler, BM Arce, GR TI Broadband multicarrier communication receiver based on analog to digital conversion in the frequency domain SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE multicarrier communication systems; analog to digital conversion in the frequency domain; ultra-wideband communications; broadband wireless communications ID DATA-TRANSMISSION; CHANNEL; EXPANSION AB This paper introduces a multicarrier communication receiver for broadband applications based on analog to digital conversion (ADC) of the received signal in the frequency domain. The samples of the spectrum of the received signal are used in the digital receiver to estimate the transmitted symbols through a matched filter operation in the discrete frequency domain. The proposed receiver is aimed at the reception of high information rates in a multicarrier signal with very large bandwidth. Thus, the receiver architecture provides a solution to some of the challenging problems found in the implementation of conventional wideband multicarrier receivers based on time-domain ADC, since it efficiently parallelizes the A/D conversion reducing the sampling speed requirements. We show that the sampling rate requirements are relaxed as the number of frequency samples is increased, which introduces a trade-off between complexity and sampling rate. The new receiver possesses additional advantages, including scalability with increasing frequency samples, the possibility of optimally allocating the available number of bits for the AID conversion across the frequency domain samples which potentially reduces the distortion introduced by the high-speed ADC, narrowband interference suppression that can be directly carried out in the frequency domain, and inherent robustness to frequency offset which makes it an attractive solution when compared with traditional multicarrier receivers. We also investigate how the proposed receiver responds to common multicarrier communication receiver problems such as phase noise and channel frequency selectivity. C1 Univ Calif Berkeley, Berkeley Wireless Res Ctr, Dept Elect & Comp Sci, Berkeley, CA 94704 USA. USA, Res Lab, Adelphi, MD 20783 USA. Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP Hoyos, S (reprint author), Univ Calif Berkeley, Berkeley Wireless Res Ctr, Dept Elect & Comp Sci, Berkeley, CA 94704 USA. EM hoyos@eecs.berkeley.edu; bsadler@arl.army.mil; arce@eecis.udel.edu NR 24 TC 14 Z9 15 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD MAR PY 2006 VL 5 IS 3 BP 652 EP 661 DI 10.1109/TWC.2006.03022 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 025TJ UT WOS:000236289500022 ER PT J AU Waag, DM McCluskie, MJ Zhang, NL Krieg, AM AF Waag, DM McCluskie, MJ Zhang, NL Krieg, AM TI A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei SO INFECTION AND IMMUNITY LA English DT Article ID BACTERIAL-DNA; DEPENDENT PROTECTION; GAMMA-INTERFERON; MURINE MODEL; INFECTION; OLIGODEOXYNUCLEOTIDE; MOTIFS; CELLS; PSEUDOMALLEI; EXPRESSION AB Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. Coley Pharmaceut Grp, Wellesley, MA USA. Coley Pharmaceut Grp, Ottawa, ON, Canada. RP Waag, DM (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.waag@amedd.army.mil NR 23 TC 32 Z9 32 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 2006 VL 74 IS 3 BP 1944 EP 1948 DI 10.1128/IAI.74.3.1944-1948.2006 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 019ED UT WOS:000235817500058 PM 16495571 ER PT J AU Trevino, SR Permenter, AR England, MJ Parthasarathy, N Gibbs, PH Waag, DM Chanh, TC AF Trevino, SR Permenter, AR England, MJ Parthasarathy, N Gibbs, PH Waag, DM Chanh, TC TI Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge SO INFECTION AND IMMUNITY LA English DT Article ID SUBTRACTIVE HYBRIDIZATION; CAPSULAR POLYSACCHARIDE; VIRULENCE DETERMINANT; PSEUDOMALLEI; IDENTIFICATION; GLANDERS AB Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Headquarters, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.waag@det.amedd.army.mil NR 17 TC 22 Z9 22 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 2006 VL 74 IS 3 BP 1958 EP 1961 DI 10.1128/IAI.74.3.1958-1961.2006 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 019ED UT WOS:000235817500061 PM 16495574 ER PT J AU Aliabadi, S Tu, S Watts, M Ji, A Johnson, A AF Aliabadi, S. Tu, S. Watts, M. Ji, A. Johnson, A. TI Integrated high performance computational tools for simulations of transport and diffusion of contaminants in urban areas SO INTERNATIONAL JOURNAL OF COMPUTATIONAL FLUID DYNAMICS LA English DT Article; Proceedings Paper CT International Workshop on Advances in Computational Mechanics CY NOV 03-06, 2004 CL Hosei Univ, Tama Campus, Tokyo, JAPAN SP Japan Soc Computat Engn & Sci, Japan Soc Mech Engineers, Div Computat Mech & Fluid Engn, Hosei Univ, Div Computat Mech & Fluid Engn, Informat Technol Res Ctr HO Hosei Univ, Tama Campus DE Light Detection and Ranging (LIDAR); high performance computing; biological aerosol; Cray X1; finite element method; transport and diffusion ID NUMERICAL-SIMULATION; AIR-FLOW; ALGORITHM; DISPERSION AB Rapid analysis of transport and diffusion of chemical and biological aerosols and contaminants in an urban environment is a critical part of any homeland security response team. High performance computing (HPC) is a valuable technique for such analysis. The time constraint needed to create fully developed complex 3D city terrain models to support such dispersion simulations requires a task of converting agency data to the format necessary on the simulation platform. Numerous data sets have been employed in the development of complex 3D city models. Such data include the use of multi-layer building morphology data, the use of geographic information system (GIS) based shapefiles and digital elevation models (DEM), and the use of remote sensing data such as Light Detection and Ranging (LIDAR). The constructed geometry models are used to generate large-scale computational domains on a platform that supports our HPC tools. These tools include fully automated unstructured mesh generation, parallel and scalable flow solvers based on stabilized finite element formulations and a remote client-server environment for large-scale flow visualization. The stabilized finite element formulations, which are based on the SUPG and PSPG techniques, are parallelized and vectorized on the Cray X1. The 3D validation problem involves transient simulation of flow past a building with a source point releasing traces. A 3D application problem is presented to demonstrate the capability of the integrated HPC tools. C1 Jackson State Univ, Sch Engn, Jackson, MS 39204 USA. Clark Atlanta Univ, Dept Engn, Atlanta, GA 30314 USA. Network Comp Serv Inc, Army HPC Res Ctr, Minneapolis, MN 55415 USA. RP Aliabadi, S (reprint author), Jackson State Univ, Sch Engn, MS E Ctr,Box 1400,1230 Raymond Rd, Jackson, MS 39204 USA. EM saliabadi@jsums.edu NR 27 TC 10 Z9 10 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1061-8562 EI 1029-0257 J9 INT J COMPUT FLUID D JI Int. J. Comput. Fluid Dyn. PD MAR-MAY PY 2006 VL 20 IS 3-4 BP 253 EP 267 DI 10.1080/10618560600793604 PG 15 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 081TP UT WOS:000240340200013 ER PT J AU Laverty, RR Gazonas, GA AF Laverty, Richard R. Gazonas, George A. TI AN IMPROVEMENT TO THE FOURIER SERIES METHOD FOR INVERSION OF LAPLACE TRANSFORMS APPLIED TO ELASTIC AND VISCOELASTIC WAVES SO INTERNATIONAL JOURNAL OF COMPUTATIONAL METHODS LA English DT Article DE Inverse laplace transform; Gibbs phenomenon; viscoelasticity; waves AB A parametric study of composite strips leads to systems of partial differential equations, coupled through interface conditions, that are naturally solved in Laplace transform space. Because of the complexity of the solutions in transform space and the potential variations due to geometry and materials, a systematic approach to inversion is necessarily numerical. The Dubner-Abate-Crump (DAC) algorithm is the standard in such problems and is implemented. The presence of discontinuous wavefronts in the problems considered leads to Gibbs phenomenon; which, in turn, overestimates the values of maximum stress. These errors are mitigated by use of Lanczos' sigma-factors, which combine naturally with the DAC algorithm. C1 [Laverty, Richard R.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Gazonas, George A.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Laverty, RR (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM Richard.Laverty@usma.edu; gazonas@arl.army.mil OI Gazonas, George/0000-0002-2715-016X FU Army Research Lab; United States Military Academy FX This work was performed while the first author (Rich Laverty) held a National Research Council Research Associateship Award at the Army Research Lab and the United States Military Academy. NR 14 TC 7 Z9 7 U1 0 U2 3 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0219-8762 EI 1793-6969 J9 INT J COMP METH-SING JI Int. J. Comput. Methods PD MAR PY 2006 VL 3 IS 1 BP 57 EP 69 DI 10.1142/S0219876206000849 PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA V11TC UT WOS:000207552900004 ER PT J AU Jain, M Skandan, G Martin, K Cho, K Klotz, B Dowding, R Kapoor, D Agrawal, D Cheng, JP AF Jain, M Skandan, G Martin, K Cho, K Klotz, B Dowding, R Kapoor, D Agrawal, D Cheng, JP TI Microwave sintering: A new approach to fine-grain tungsten - I SO INTERNATIONAL JOURNAL OF POWDER METALLURGY LA English DT Article AB Recently, there has been a renewed interest in fine-grain dense objects of refractory metals containing no liquid-phase sintering aids. This has been the motivation for exploring new sintering techniques, and using ultrafine powders as the starting material. In the work reported here, two different types of commercially available and two experimental grades of tungsten powders were microwave sintered in the absence of additives. The effects of primary particle size, phase purity, aggregate size, and morphology on densification behavior have been studied. There was no direct correlation between the characteristics of the as-received powders and the sintered density for example, a smaller initial, particle size did not lead to higher sintered densities. even with higher green densities. The densification behavior was governed by a combination of particle characteristics. In contrast to conventional sintering, it was found that in microwave sintering, the degree of densification increased with increasing aspect ratio. Densities greater than or similar to 98.5% of the pore-free level were achieved with a grain size in the range of 2-4 pm by microwave sintering-followed by hot isostatic pressing (HIPing) at a temperature as low as 1,500 degrees C. In the absence of HIPing, the density of microwave sintered tungsten was 12%-18% higher than the density of conventionally sintered tungsten. C1 NEI Corp, Somerset, NJ 08873 USA. USA, Res Lab, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. AMSTA AR WEA, Picatinny Arsenal, NJ 07806 USA. Penn State Univ, Mat Res Lab, College Pk, PA 16802 USA. RP Jain, M (reprint author), NEI Corp, 400 Apgar Dr,Suite E, Somerset, NJ 08873 USA. EM mjain@neicorporation.com RI Dowding, Robert/F-1469-2015 OI Dowding, Robert/0000-0002-4763-2131 NR 4 TC 22 Z9 26 U1 2 U2 5 PU AMER POWDER METALLURGY INST PI PRINCETON PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA SN 0888-7462 J9 INT J POWDER METALL JI Int. J. Powder Metall. PD MAR-APR PY 2006 VL 42 IS 2 BP 45 EP 50 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA 036RD UT WOS:000237091800008 ER PT J AU Jain, M Skandan, G Martin, K Kapoor, D Cho, K Klotz, B Dowding, R Agrawal, D Cheng, JP AF Jain, M Skandan, G Martin, K Kapoor, D Cho, K Klotz, B Dowding, R Agrawal, D Cheng, JP TI Microwave sintering: A new approach to fine-grain tungsten - II SO INTERNATIONAL JOURNAL OF POWDER METALLURGY LA English DT Article AB While grain-growth inhibition in micrograined refractory metals and ceramics is well documented, a reduction in grain size to the nanoscale is relatively new. In the work reported here, nanocrystalline tungsten powders containing small amounts of HfO2 and Y2O3 as dopants were synthesized using a solution-synthesis technique. The as-synthesized powders were then consolidated using microwave sintering. The effect of dopant concentration on the crystallite size. particle size, and grain size of the sintered material was monitored. Average grain sizes as low as 0.5 mu m were achieved in doped microwave-sintered tungsten: this grain size is substantially smaller than previously reported. namely similar to 2 mu m in undoped tungsten. It was also observed that an optimum level of dopant exists for effective grain-growth inhibition. since the sintering of tungsten is hindered at higher dopant levels. C1 NEI Corp, Somerset, NJ 08873 USA. AMSTA AR WEA, Picatinny Arsenal, NJ 07806 USA. USA, Mat Lab, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. Penn State Univ, Mat Res Lab 207, College Pk, PA 16802 USA. RP Jain, M (reprint author), NEI Corp, 400 Apgar Dr,Suite E, Somerset, NJ 08873 USA. EM mjain@neicorporation.com RI Dowding, Robert/F-1469-2015 OI Dowding, Robert/0000-0002-4763-2131 NR 6 TC 15 Z9 15 U1 0 U2 4 PU AMER POWDER METALLURGY INST PI PRINCETON PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA SN 0888-7462 J9 INT J POWDER METALL JI Int. J. Powder Metall. PD MAR-APR PY 2006 VL 42 IS 2 BP 53 EP 57 PG 5 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA 036RD UT WOS:000237091800009 ER PT J AU Tevault, DE Buchanan, JH Buettner, LC AF Tevault, D. E. Buchanan, J. H. Buettner, L. C. TI Ambient volatility of DMMP SO INTERNATIONAL JOURNAL OF THERMOPHYSICS LA English DT Article; Proceedings Paper CT 15th Symposium on Thermophysical Properties CY JUN 22-27, 2003 CL Univ Colorado, BOULDER, CO SP Amer Soc Mech Engineers, Heat Transfer Div, Natl Inst Stand & Technol, Phys & Chem Properties Div HO Univ Colorado DE dimethyl methylphosphonate; mixture; two-component vapor-liquid equilibrium; water AB A novel experimental apparatus and procedures have been developed and implemented to measure the volatility of a chemical warfare agent simulant as a function of ambient temperature and water vapor partial pressure. Initial data have been measured for dimethyl methylphosphonate (DMMP) to validate the methodology. The results presented herein reveal a significant volatility suppression for DMMP, increasing as the relative humidity increases. Deviation from ideal behavior as described by Raoult's law has been quantified. The maximum deviation from ideality occurs at water partial pressures near 500 Pa. An empirical model has been developed to enable interpolation and limited extrapolation of the data to higher water partial pressures as might be found in compressed-air regenerative filtration applications. C1 USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, AMSRD ECB RT, Aberdeen Proving Ground, MD 21010 USA. RP Tevault, DE (reprint author), USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, AMSRD ECB RT, Aberdeen Proving Ground, MD 21010 USA. EM david.tevault@us.army.mil NR 5 TC 10 Z9 10 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0195-928X J9 INT J THERMOPHYS JI Int. J. Thermophys. PD MAR PY 2006 VL 27 IS 2 BP 486 EP 493 DI 10.1007/s10765-006-0044-3 PG 8 WC Thermodynamics; Chemistry, Physical; Mechanics; Physics, Applied SC Thermodynamics; Chemistry; Mechanics; Physics GA 065OD UT WOS:000239168300009 ER PT J AU Hoge, CW Auchterlonie, JL Milliken, CS AF Hoge, CW Auchterlonie, JL Milliken, CS TI Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR VETERANS; PSYCHIATRIC-DISORDERS; VIETNAM VETERANS; PRIMARY-CARE; POPULATION; ILLNESS; DEPRESSION; PERSONNEL; VALIDITY AB Context The US military has conducted population-level screening for mental health problems among all service members returning from deployment to Afghanistan, Iraq, and other locations. To date, no systematic analysis of this program has been conducted, and studies have not assessed the impact of these deployments on mental health care utilization after deployment. Objectives To determine the relationship between combat deployment and mental health care use during the first year after return and to assess the lessons learned from the postdeployment mental health screening effort, particularly the correlation between the screening results, actual use of mental health services, and attrition from military service. Design, Setting, and Participants Population-based descriptive study of all Army soldiers and Marines who completed the routine postdeployment health assessment between May 1, 2003, and April 30, 2004, on return from deployment to Operation Enduring Freedom in Afghanistan ( n= 16 318), Operation Iraqi Freedom ( n= 222 620), and other locations ( n= 64 967). Health care utilization and occupational outcomes were measured for 1 year after deployment or until leaving the service if this occurred sooner. Main Outcome Measures Screening positive for posttraumatic stress disorder, major depression, or other mental health problems; referral for a mental health reason; use of mental health care services after returning from deployment; and attrition from military service. Results The prevalence of reporting a mental health problem was 19.1% among service members returning from Iraq compared with 11.3% after returning from Afghanistan and 8.5% after returning from other locations ( P <. 001). Mental health problems reported on the postdeployment assessment were significantly associated with combat experiences, mental health care referral and utilization, and attrition from military service. Thirty-five percent of Iraq war veterans accessed mental health services in the year after returning home; 12% per year were diagnosed with a mental health problem. More than 50% of those referred for a mental health reason were documented to receive follow-up care although less than 10% of all service members who received mental health treatment were referred through the screening program. Conclusions Combat duty in Iraq was associated with high utilization of mental health services and attrition from military service after deployment. The deployment mental health screening program provided another indicator of the mental health impact of deployment on a population level but had limited utility in predicting the level of mental health services that were needed after deployment. The high rate of using mental health services among Operation Iraqi Freedom veterans after deployment highlights challenges in ensuring that there are adequate resources to meet the mental health needs of returning veterans. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.hoge@usarmy.mil NR 25 TC 911 Z9 919 U1 15 U2 66 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 1 PY 2006 VL 295 IS 9 BP 1023 EP 1032 DI 10.1001/jama.295.9.1023 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 016XJ UT WOS:000235656600022 PM 16507803 ER PT J AU Wolf, SE Edelman, LS Kemalyan, N Donison, L Cross, J Underwood, M Spence, RJ Noppenberger, D Palmieri, TL Greenhalgh, DG Lawless, M Voigt, D Edwards, P Warner, P Kagan, R Hatfield, S Jeng, J Crean, D Hunt, J Purdue, G Burris, A Cairns, B Kessler, M Klein, RL Baker, R Yowler, C Tutulo, W Foster, K Caruso, D Hildebrand, B Benjamin, W Villarreal, C Sanford, AP Saffle, J AF Wolf, SE Edelman, LS Kemalyan, N Donison, L Cross, J Underwood, M Spence, RJ Noppenberger, D Palmieri, TL Greenhalgh, DG Lawless, M Voigt, D Edwards, P Warner, P Kagan, R Hatfield, S Jeng, J Crean, D Hunt, J Purdue, G Burris, A Cairns, B Kessler, M Klein, RL Baker, R Yowler, C Tutulo, W Foster, K Caruso, D Hildebrand, B Benjamin, W Villarreal, C Sanford, AP Saffle, J TI Effects of oxandrolone on outcome measures in the severely burned: A multicenter prospective randomized double-blind trial SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Burn-Association CY MAR 24-27, 2004 CL Vancouver, CANADA SP Amer Burn Assoc ID DERMAL REGENERATION TEMPLATE; TESTOSTERONE ANALOG; FIBRIN SEALANT; CLINICAL-TRIAL; WEIGHT-LOSS; INJURY; CATABOLISM; EFFICACY; EVALUATE; WOUNDS AB Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown to decrease lean mass catabolism and improve wound healing in the severely burned patients. We enrolled 81 adult subjects with burns 20% to 60% TBSA in a multicenter trial testing the effects of oxandrolone on length of hospital stay. Subjects were randomized between oxandrolone 10 mg every 12 hours or placebo. The study was stopped halfway through projected enrollment because of a significant difference between groups found on planned interim analysis. We found that length of stay was shorter in the oxandrolone group (31.6 +/- 3.1 days) than placebo (43.3 +/- 5.3 days; P <.05). This difference strengthened when deaths were excluded and hospital stay was indexed to burn size (1.24 +/- 0.15 days/% TBSA burned vs 0.87 +/- 0.05 days/% TBSA burned, P <.05). We conclude that treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored. C1 Univ Texas, Med Branch, Blocker Burn Unit, BART, Galveston, TX 77555 USA. Univ Utah, Hlth Sci Ctr, Intermt Burn & Trauma Ctr, Salt Lake City, UT 84112 USA. Johns Hopkins Bayview Med Ctr, Baltimore Reg Burn Ctr, Baltimore, MD USA. Metrohlth Med Ctr, Cleveland, OH USA. Univ Cincinnati, Dept Surg, Cincinnati, OH 45221 USA. Univ Calif Davis, Davis Reg Burn Ctr, Davis, CA 95616 USA. Univ Alabama Hosp & Clin, Arizona Burn Ctr, Birmingham, AL USA. St Elizabeth Hosp, Lincoln, NE USA. Univ N Carolina, N Carolina Jaycee Burn Ctr, Chapel Hill, NC 27515 USA. Reg Burn Trauma Ctr, Akron, OH USA. RP Wolf, SE (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, 3400 Rawley E Chambers Dr, San Antonio, TX 78251 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 26 TC 63 Z9 64 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2006 VL 27 IS 2 BP 131 EP 139 DI 10.1097/01.BCR.0000202620.55751.4F PG 9 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 044UL UT WOS:000237697800002 PM 16566555 ER PT J AU He, JK Innis, BL Shrestha, MP Clayson, ET Scott, RM Linthicum, KJ Musser, GG Gigliotti, SC Binn, LN Kuschner, RA Vaughn, DW AF He, JK Innis, BL Shrestha, MP Clayson, ET Scott, RM Linthicum, KJ Musser, GG Gigliotti, SC Binn, LN Kuschner, RA Vaughn, DW TI Evidence that rodents are a reservoir of hepatitis E virus for humans in Nepal (Retraction of vol 40, pg 4493, 2002) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Walter Reed Army Inst Res, Armed Forces Res Inst Med Sci, Res Unit, Kathmandu, Nepal. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Amer Museum Nat Hist, New York, NY 10024 USA. RP He, JK (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. NR 1 TC 7 Z9 9 U1 3 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 2006 VL 44 IS 3 BP 1208 EP 1208 DI 10.1128/JCM.44.3.1208.2006 PG 1 WC Microbiology SC Microbiology GA 022ZP UT WOS:000236095000098 PM 16517936 ER PT J AU Bui-Mansfield, LT DeWitt, RM AF Bui-Mansfield, LT DeWitt, RM TI Magnetic resonance imaging appearance of a double anterior cruciate ligament associated with a displaced tear of the lateral meniscus SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE magnetic resonance imaging; meniscal tear; sports medicine; musculoskeletal imaging ID BUCKET-HANDLE TEARS; BOW TIE SIGN; KNEE; MRI; FRAGMENTS AB The aim of this Study is to report a novel description of a displaced tear of the lateral meniscus as a Curvilinear low signal intensity band parallel and posteroinferior to the anterior cruciate ligament (ACL) on midline oblique sagittal magnetic resonance (MR) images, resulting in the appearance of a "double ACL." The appearance of a double ACL may potentially be a specific indicator for a lateral meniscal displaced tear. Increased awareness of this characteristic MR finding may increase accuracy in the diagnosis of displaced tears of the lateral meniscus. C1 San Antonio Uniformed Serv Hlth Educ Consortium, Dept Radiol, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Wake Forest Univ, Dept Radiol, Winston Salem, NC 27109 USA. USUHS, Dept Radiol, Bethesda, MD USA. RP Bui-Mansfield, LT (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dept Radiol, Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@gmail.com NR 10 TC 1 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAR-APR PY 2006 VL 30 IS 2 BP 327 EP 332 DI 10.1097/00004728-200603000-00032 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 028HU UT WOS:000236478600032 PM 16628058 ER PT J AU Yang, JZ Marler, RT Beck, S Abdel-Malek, K Kim, J AF Yang, JZ Marler, RT Beck, S Abdel-Malek, K Kim, J TI Real-time optimal reach-posture prediction in a new interactive virtual environment SO JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY LA English DT Article DE reach posture prediction; MOO; human modeling and simulation; virtual environment ID ERGONOMIC EVALUATION; ROBOT MANIPULATORS; OPTIMIZATION; CONSTRAINTS; ALGORITHM; DESIGN; MODEL AB Human posture prediction is a key factor for the design and evaluation of workspaces, in a virtual environment using virtual humans. This work presents a new interface and virtual environment for the direct human optimized posture prediction (D-HOPP) approach to predicting realistic reach postures of digital humans, where reach postures entail the use of the torso, arms, and neck. D-HOPP is based on the contention where depending on what type of task is being completed, and human posture is governed by different human performance measures. A human performance measure is a physics-based metric, such as energy or discomfort, and serves as an objective function in an optimization formulation. The problem is formulated as a single-objective optimization (SOO) problem with a single performance measure and as multi-objective-optimization (MOO) problem with multiple combined performance measures. We use joint displacement, change in potential energy, and musculoskeletal discomfort as performance measures. D-HOPP is equipped with ail extensive yet intuitive user-interface, and the results are presented in an interactive virtual environment. C1 Univ Iowa, USA, Virtual Soldier Res Program, Ctr Comp Aided Design, Iowa City, IA 52242 USA. RP Univ Iowa, USA, Virtual Soldier Res Program, Ctr Comp Aided Design, 111 Engn Res Facil, Iowa City, IA 52242 USA. EM jyang@engineering.uiowa.edu RI Yang, James/G-9801-2012; Kim, Joo/I-9517-2012 NR 42 TC 21 Z9 21 U1 1 U2 6 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1000-9000 EI 1860-4749 J9 J COMPUT SCI TECH-CH JI J. Comput. Sci. Technol. PD MAR PY 2006 VL 21 IS 2 BP 189 EP 198 DI 10.1007/s11390-006-0189-3 PG 10 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA 025UP UT WOS:000236292700007 ER PT J AU Dalton, SR Fillman, EP Ferringer, T Tyler, W Elston, DM AF Dalton, SR Fillman, EP Ferringer, T Tyler, W Elston, DM TI Smooth muscle pattern is more reliable than the presence or absence of an internal elastic lamina in distinguishing an artery from a vein SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article AB Background: Major pathology textbooks suggest that the shape of the vessel and the presence or absence of an internal elastic lamina are the best means to distinguish an artery from a vein. Because the shape of the vessel is highly dependent upon the plane of section, the internal elastic lamina is often cited as a more reliable criterion. After evaluating a patient with superficial thrombophlebitis, in whom these conventional criteria had led to a misdiagnosis of polyarteritis nodosa, we sought to determine whether the pattern of smooth muscle in the media is a more sensitive discriminator between an artery and a vein. Methods: Anatomically identified arteries and veins were harvested from extremity amputation specimens and stored autopsy organ specimens and reviewed by two dermatopathologists who were blinded to the gross pathologist's impression. The biopsies were assessed for the smooth muscle pattern and the presence or absence of an internal elastic lamina. Results: Forty-seven of the 50 cases (94%) were concordant with the pathologist's gross impression using only the smooth muscle pattern to differentiate an artery from a vein. On the basis of the presence or absence of an internal elastic lamina, 41 of 50 cases (82%) were concordant with the prosector's designation of the vessel. Limitations: Vessels were harvested from a variety of sites, with lower extremity vessels predominating. There may be some regional variability not addressed in this study. Conclusion: In this study, the pattern of muscle fibers within the vascular media discriminated between arteries and veins better than assessment of the presence or absence of an internal elastic lamina. Although no single criterion is 100% reliable, assessment of both these criteria may minimize the risk of misinterpreting vessels in the deep dermis and subcutis. C1 Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA. Wilford Hall USAF Med Ctr, San Antonio, TX USA. Geisinger Med Ctr, Dept Pathol, Danville, PA 17822 USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17822 USA. EM dmelston@geisinger.edu NR 9 TC 9 Z9 10 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD MAR PY 2006 VL 33 IS 3 BP 216 EP 219 DI 10.1111/j.0303-6987.2006.00419.x PG 4 WC Dermatology; Pathology SC Dermatology; Pathology GA 010QZ UT WOS:000235210500003 PM 16466508 ER PT J AU Anderson, DN Joyce, AP Roberts, S Runner, R AF Anderson, DN Joyce, AP Roberts, S Runner, R TI A comparative photoelastic stress analysis of internal root stresses between RC Prep and saline when applied to the Profile/GT rotary instrumentation system SO JOURNAL OF ENDODONTICS LA English DT Article DE GT Profile; lubricant; photoelastic; profile; RC prep; saline ID NICKEL-TITANIUM INSTRUMENTS; ISO SIZED TIPS; SHAPING ABILITY; ENDODONTIC INSTRUMENTS; TORSIONAL PROPERTIES; SIMULATED CANALS; CYCLIC FATIGUE; CLINICAL-USE; PART 1; FILES AB The purpose of this study was to measure and compare the amount of stress produced by GT ProFile (GT) and ProFile (PF) rotary files lubricated with either RC Prep (RCP) or saline (S) on the walls of prepared simulated canals. Twenty-four 10-mm long canals with a 10 mm radius of curvature were prepared in PL-2 photoelastic acrylic blocks which were lubricated with either RCP or S. The files were inserted into a Nouvag handpiece mounted to an Instron 4502 universal testing machine and lowered into the canal at a rate of 60 mm/min and a rotational speed of 300 RPM. The following four GTs and four PFs were sequentially introduced into predetermined depths of each canal: 20/10, 201.08, 20/.06, 20/.04, 40/.04, 35/.04, 3004, and 25/.04. Total areas of stress created by each file were captured by digital video images and measured using Image J software. Statistical analysis of the data was performed using a two-way ANOVA (p < 0.05, n = 24). The GT/RCP group demonstrated a significant average of 64.22% less stress than GT/S group. The PF (25, 30, and 35)/ RCP groups demonstrated a significant average of 27.02% less stress than the same S groups. PF (40) produced a negligible amount of stress regardless of the lubricant type. The results reveal that using RCP as a lubricant when instrumenting curved canals with GT and PF results in less stress when compared to saline. C1 USA, Endodont Residency Program, DENTAC, Tingay Dent Clin, Ft Gordon, GA 30905 USA. Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Joyce, AP (reprint author), USA, Endodont Residency Program, DENTAC, Tingay Dent Clin, Ft Gordon, GA 30905 USA. EM Anthony.Joyce@se.amedd.army.mil NR 34 TC 7 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 2006 VL 32 IS 3 BP 222 EP 224 DI 10.1016/j.joen.2005.10.053 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 018SW UT WOS:000235786100012 PM 16500231 ER PT J AU Wang, P Linker, LC Batiuk, R Cerco, C AF Wang, P Linker, LC Batiuk, R Cerco, C TI Surface analysis of Chesapeake Bay water quality response to different nutrient and sediment loads SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID EUTROPHICATION; IMPROVEMENT; NITROGEN; ANOXIA AB Based on a set of Chesapeake Bay Estuarine Model (CBEM) scenarios, a three-dimensional response surface of a water quality index, such as chlorophyll concentration, versus a pair of loading constituents, e.g., nitrogen and phosphorus, is constructed. The responses of water quality, Such as dissolved oxygen, chlorophyll, and water clarity, to nitrogen, phosphorus, and sediment loads are analyzed. From the response surface, a water quality response is estimated under loading conditions beyond that of a limited set of scenarios. Response Surfaces may be used to determine the possible universe of nutrient and sediment load reductions needed to obtain a particular water quality standard and to examine the tradeoffs among nutrient and sediment load reductions that achieve the same water quality objective. C1 Univ Maryland, Ctr Environm Sci, Annapolis, MD 21403 USA. US EPA, Chesapeake Bay Program Off, Annapolis, MD 21403 USA. USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Wang, P (reprint author), Univ Maryland, Ctr Environm Sci, 410 Severn Ave, Annapolis, MD 21403 USA. EM pwang@chesapeakebay.net; linker.lewis@epa.gov; batiuk.richard@epa.gov; Carl.F.Cerco@erdc.usace.army.mil NR 28 TC 8 Z9 8 U1 1 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD MAR PY 2006 VL 132 IS 3 BP 377 EP 383 DI 10.1061/(ASCE)0733-9372(2006)132:3(377) PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 016OP UT WOS:000235629900013 ER PT J AU Moss, RES Seed, RB Olsen, RS AF Moss, RES Seed, RB Olsen, RS TI Normalizing the CPT for overburden stress SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID UNDRAINED CAVITY EXPANSION; CONE-PENETRATION TEST; LIQUEFACTION RESISTANCE; PIEZOCONE TEST; SOILS; CLAY; SANDS; TESTS AB Effective overburden stress can have a significant influence on cone penetration test (CPT) measurements. This influence can lead to an incorrect assessment of soil strength/resistance for such purposes as liquefaction triggering analysis. For an accurate measurement of tip and sleeve resistance, unbiased by overburden stress, it is essential to normalize these index measurements appropriately. Presented herein is a comprehensive study reviewing all aspects of CPT normalization. A result of this study is a variable normalization procedure for the CPT that is based on both empirical results and theoretical analysis. This paper presents these results in the form of an improved normalization scheme and discusses its application in practice. C1 Calif Polytech State Univ San Luis Obispo, Dept Civil & Environm Engn, San Luis Obispo, CA 93407 USA. Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA. USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39108 USA. RP Moss, RES (reprint author), Calif Polytech State Univ San Luis Obispo, Dept Civil & Environm Engn, San Luis Obispo, CA 93407 USA. EM rmoss@calpoly.edu NR 38 TC 25 Z9 25 U1 5 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAR PY 2006 VL 132 IS 3 BP 378 EP 387 DI 10.1061/(ASCE)1090-0241(2006)132:3(378) PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 016AM UT WOS:000235592900007 ER PT J AU Taylor, KF Parks, BG Segalman, KA AF Taylor, KF Parks, BG Segalman, KA TI Biomechanical stability of a fixed-angle volar plate versus fragment-specific fixation system: Cyclic testing in a C2-type distal radius cadaver fracture model SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE distal radius fracture; fixed-angle volar plate; fragment-specific fixation ID DYNAMIC EXTERNAL FIXATION; REDISPLACED UNSTABLE FRACTURES; DORSALLY DISPLACED FRACTURES; INTERNAL-FIXATION; INTRAARTICULAR FRACTURES; COLLES FRACTURES; OPEN REDUCTION; YOUNG-ADULTS; WRIST; MOTION AB Purpose: To compare the biomechanical stability of 2 recently introduced fixation systems in an intra-articular, dorsal comminution distal radius fracture model. Methods: AO/ASIF type C2 fractures were simulated in 10 matched pairs of fresh-frozen cadaveric arms randomized between fixed-angle volar plate and fragment-specific fixation systems. Specimens were loaded in extension cyclically for 2,000 repetitions followed by a single cycle to failure. Initial, intermediate, and final stiffness values and failure load values were obtained and compared. Results: Both systems were able to sustain physiologic cyclic loading. The fragment-specific system was significantly stiffer than the fixed-angle volar plate system for the ulnar segment in both the precycle and postcycle values. No other comparisons were significant with respect to stiffness. No significant difference in load to failure was found between the systems with respect to ulnar, radial, or overall fragment displacement. Conclusions: Both fixed-angle volar plate and fragment-specific: fixation systems performed comparably in a simulated early postoperative motion protocol. Fragment-specific fixation had improved stiffness characteristics only with respect to the smaller ulnar-sided fragment. C1 Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. Raymond M Curtis Natl Hand Ctr, Baltimore, MD USA. RP Taylor, KF (reprint author), Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. EM Kenneth.Taylor@amedd.army.mil NR 38 TC 31 Z9 33 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD MAR PY 2006 VL 31A IS 3 BP 373 EP 381 DI 10.1016/j.jhsa.2005.12.017 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 022VO UT WOS:000236084400004 PM 16516730 ER PT J AU Vanderploeg, RD Collins, RC Sigford, B Date, E Schwab, K Warden, D AF Vanderploeg, RD Collins, RC Sigford, B Date, E Schwab, K Warden, D CA Defense Veterans Brain Injury Ctr TI Practical and theoretical considerations in designing rehabilitation trials - The DVBIC cognitive-didactic versus functional-experiential treatment study experience SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article; Proceedings Paper CT Galveston Brain Injury Conference (GBIC) CY APR, 2005 CL Galveston, TX SP Moody Fdn DE outcome assessment; randomized controlled trials; rehabilitation; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; CLOSED-HEAD-INJURY; REORGANIZATION; PROGRAM AB This is a descriptive article outlining issues in the development and implementation of a multisite randomized rehabilitation trial for brain injury treatment. The goal of this article is to present practical and theoretical considerations in designing and conducting multicenter rehabilitation trials. Practical issues discussed include (a) treatment setting, (b) patient accessibility in determining the research question of interest, as well as inclusion and exclusion criteria, (c) research protocol development in the context of rehabilitation standard of care, and (d) protocol treatments in the context of realistic cost-benefits analysis. Rehabilitation theory is discussed as playing an important role designing the specifics of the protocol interventions. The Defense and Veterans Brain Injury Center Veterans Health Administration cognitive-didactic versus functional-experiential study methodology is used for illustrative purposes. This study evaluated 2 alternative approaches to treatment: one focusing on underlying cognitive processes and the second on errorless learning in everyday functional situations. Lessons learned over the course of completing the treatment trial are discussed. C1 Univ S Florida, James A Haley Vet Affairs Med Ctr, Def & Vet Brain Injury Ctr, Tampa, FL USA. Univ S Florida, Dept Psychiat & Behav Sci, Tampa, FL USA. Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. Vet Affairs Med Ctr, Def & Vet Brain Injury Ctr, Minneapolis, MN USA. Def & Vet Brain Injury Ctr, Minneapolis, MN USA. Univ Minnesota, Dept Phys Med & Rehabil, Minneapolis, MN USA. Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv, Palo Alto, CA USA. Stanford Univ, Dept Phys Med & Rehabil, Sch Med, Palo Alto, CA 94304 USA. Uniformed Serv Univ Hlth Sci, Dept Epidemiol & Stat, Def & Vet Brain Injury Ctr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Def & Vet Brain Injury, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol & Psychiat, Bethesda, MD 20814 USA. RP Vanderploeg, RD (reprint author), James A Haley Vet Hosp, Psychol Serv 116B, Tampa, FL 33612 USA. EM rodney.vanderploeg@va.gov NR 61 TC 17 Z9 19 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD MAR-APR PY 2006 VL 21 IS 2 BP 179 EP 193 PG 15 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 031PK UT WOS:000236716300009 PM 16569991 ER PT J AU Forest, JJF AF Forest, JJF TI The scholarship of teaching and learning in higher education: Contributions of research universities SO JOURNAL OF HIGHER EDUCATION LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Forest, JJF (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 6 TC 0 Z9 0 U1 0 U2 7 PU OHIO STATE UNIV PRESS PI COLUMBUS PA 1050 CARMACK RD, COLUMBUS, OH 43210 USA SN 0022-1546 J9 J HIGH EDUC JI J. High. Educ. PD MAR-APR PY 2006 VL 77 IS 2 BP 378 EP 380 DI 10.1353/jhe.2006.0012 PG 3 WC Education & Educational Research SC Education & Educational Research GA 023VK UT WOS:000236154100008 ER PT J AU Hu, HH Kreymborg, LR Doeing, BJ Baron, KS Jutila, SA AF Hu, HH Kreymborg, LR Doeing, BJ Baron, KS Jutila, SA TI Gridded snowmelt and rainfall-runoff CWMS hydrologic modeling of the Red River of the North Basin SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article AB In order to reduce future flood damage in the Red River of the North Basin, the U.S. Army Corps of Engineers, St. Paul District, is developing a Corps Water Management System (CWMS) to assist in real-time operation of reservoirs to regulate reservoir outflows. This paper presents ail application of the distributed snow process model (DSPM) and the Hydrologic Engineering Center's Hydrologic Modeling System (HEC-HMS) in gridded snowmelt and rainfall-runoff modeling for reservoir operational forecasting, which is an essential component of the CWMS model. The model setup, calibration, and verification are described. The paper particularly focuses on information requirements of DSPM and HEC-HMS for model setup/calibration and continuing forecast operations and shows how these requirements Could be met in a practical and operational setting. Elements of the modeling process that are important for operational forecasting are discussed and are expected to benefit similar CWMS operational forecasting in other watersheds both in cold and warm regions. C1 WEST Consultants Inc, San Diego, CA 92127 USA. WEST Consultants Inc, Tempe, AZ 85254 USA. WEST Consultant Inc, Bellevue, WA 98005 USA. WEST Consultants Inc, San Diego, CA 92127 USA. USA, Hydraul Engn Hydraul & Hydrol Sect, St Paul, MN 55101 USA. RP Hu, HH (reprint author), WEST Consultants Inc, 16870 W Bernardo Dr,Suite 340, San Diego, CA 92127 USA. EM hhu@westconsultants.com; leok@westconsultants.com; brian.doeing@hdrinc.com; kbaron@westconsultants.com; Scott.A.Jutila@mvp02.usace.army.mil NR 14 TC 5 Z9 5 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD MAR-APR PY 2006 VL 11 IS 2 BP 91 EP 100 DI 10.1061/(ASCE)1084-0699(200611:2(91) PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 016CL UT WOS:000235598200001 ER PT J AU Turell, MJ Mores, CN Dohm, DJ Komilov, N Paragas, J Lee, JS Shermuhemedova, D Endy, TP Kodirov, A Khodjaev, S AF Turell, MJ Mores, CN Dohm, DJ Komilov, N Paragas, J Lee, JS Shermuhemedova, D Endy, TP Kodirov, A Khodjaev, S TI Laboratory transmission of Japanese encephalitis and West Nile viruses by molestus form of Culex pipiens (Diptera : Culicidae) collected in Uzbekistan in 2004 SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE transmission; mosquitoes; Uzbekistan; Japanese encephalitis; West Nile ID VALLEY FEVER VIRUS; MOSQUITOS; TRITAENIORHYNCHUS; OUTBREAK AB We evaluated the molestus form of Culex pipiens pipiens (L.) (hereafter referred to as "molestus") captured near Tashkent, Uzbekistan, for their ability to transmit Japanese encephalitis (family Flaviviridae, genus Flavivirus, JEV) and West Nile (family Flaviviridae, genus Flavivirus, WNV) viruses under laboratory conditions. These molestus were highly competent laboratory vectors of WNV, with infection and dissemination rates of 96 and 81%, respectively. Approximately 75% of female molestus that fed after development of a disseminated infection transmitted virus by bite. Therefore, approximate to 60% of those molestus taking a second bloodmeal between 16 and 25 d after an infectious bloodmeal would be expected to transmit WNV by bite. In contrast, these molestus were less efficient vectors of JEV, with infection and dissemination rates of 51 and 25%, respectively. In addition, only 33% of individuals with a disseminated infection transmitted JEV by bite, indicating a significant salivary gland barrier. Therefore, only approximate to 8% of orally exposed individuals would be expected to transmit JEV by bite if they took a second bloodmeal 16-25 d later. These data indicate that the molestus form of Cx. p. pipiens should be considered a potentially important vector of WNV in Uzbekistan and may become involved in the transmission of JEV, should this virus be introduced into Uzbekistan. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Minist Hlth, Inst Virol, Tashkent, Uzbekistan. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RI Valle, Ruben/A-7512-2013 NR 29 TC 22 Z9 22 U1 0 U2 3 PU ENTOMOLOGICAL SOCIETY AMERICA PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 2006 VL 43 IS 2 BP 296 EP 300 DI 10.1603/0022-2585(2006)043[0296:LTOJEA]2.0.CO;2 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 024GX UT WOS:000236184600025 PM 16619614 ER PT J AU Taber, KH Warden, DL Hurley, RA AF Taber, KH Warden, DL Hurley, RA TI Blast-related traumatic brain injury: What is known? SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID DIFFUSE AXONAL INJURY; INDUCED NEUROTRAUMA; HEAD-INJURY; RAT-BRAIN; CONCUSSION; EXPERIENCE; VETERANS; NEURONS C1 Salisbury Vet Affairs Med Ctr, Vet Affairs Mid Atlantic Mental Illness Res, Educ & Clin Ctr, Salisbury, NC USA. Salisbury Vet Affairs Med Ctr, Mental Hlth Serv, Salisbury, NC USA. Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA. Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Wake Forest Univ, Sch Med, Dept Psychiat, Winston Salem, NC 27109 USA. Wake Forest Univ, Sch Med, Dept Radiol, Winston Salem, NC 27109 USA. Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA. RP Hurley, RA (reprint author), Hefner VA Med Ctr, 1601 Brenner Ave, Salisbury, NC 28144 USA. EM Hurley@med.va.gov NR 38 TC 224 Z9 226 U1 1 U2 18 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD SPR PY 2006 VL 18 IS 2 BP 141 EP 145 DI 10.1176/appi.neuropsych.18.2.141 PG 5 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 044KU UT WOS:000237672000001 PM 16720789 ER PT J AU Shaw, LJ Taylor, A Raggi, P Berman, DS AF Shaw, LJ Taylor, A Raggi, P Berman, DS TI Role of noninvasive imaging in asymptomatic high-risk patients SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Nuclear-Cardiology CY SEP 29-OCT 02, 2005 CL Seattle, WA SP Amer Soc Nucl Cardiol, Astellas Pharma US Inc, astellas, GE Healthcare ID CORONARY-ARTERY CALCIUM; BEAM COMPUTED-TOMOGRAPHY; AMERICAN-HEART-ASSOCIATION; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; ATHEROSCLEROTIC PLAQUE; MYOCARDIAL-INFARCTION; DISEASE EVENTS; CALCIFICATION; WOMEN C1 Univ Calif Los Angeles, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90048 USA. Walter Reed Army Med Ctr, Bethesda, MD USA. Emory Univ, Sch Med, Atlanta, GA USA. RP Shaw, LJ (reprint author), Univ Calif Los Angeles, Cedars Sinai Med Ctr, Room 1254,Taper Bldg,8700 Beverly Blvd, Los Angeles, CA 90048 USA. EM leslee.shaw@cshs.org NR 37 TC 5 Z9 5 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 1071-3581 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD MAR-APR PY 2006 VL 13 IS 2 BP 156 EP 162 DI 10.1016/j.nuclcard.2006.02.006 PG 7 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA 030FU UT WOS:000236620600005 PM 16580949 ER PT J AU McClung, JP Stahl, CH Marchitelli, LJ Morales-Martinez, N Mackin, KM Young, AJ Scrimgeour, AG AF McClung, JP Stahl, CH Marchitelli, LJ Morales-Martinez, N Mackin, KM Young, AJ Scrimgeour, AG TI Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE phytase; zinc; dual X-ray absorptiometry; bone strength; rats ID PHYTIC ACID; MICROBIAL PHYTASE; IRON-ABSORPTION; DEFICIENT RATS; GROWTH; SUPPLEMENTATION; BIOAVAILABILITY; AVAILABILITY; PIGS; CHILDREN AB Phytic acid, a major phosphorous storage compound found in foodstuffs, is known to form insoluble complexes with nutritionally essential minerals, including zinc (Zn). Phytases are enzymes that catalyze the removal of these minerals from phytic acid, improving their bioavailability. The objective of the present study was to determine the ability of dietary phytase to affect body weight, body composition, and bone strength in growing rats fed a high phytic acid, low Zn diet. Rats (n=20) were fed either a control (AIN-93) or phytase supplemented (Natuphos, BASF, 1,500 phytase units (FTU)/kg) diet for a period of 8 weeks. Phytase supplementation resulted in increased (P <.05) bone and plasma Zn, but no change in plasma inorganic phosphorous or bone levels of Ca, Fe, or Mg. The addition of phytase to the diets resulted in a 22.4% increase (P <.05) in body weight at the end of the study as compared with rats fed a control diet. Dual x-ray absorptiometry (DXA) revealed that phytase supplementation resulted in increase lean body mass (LBM, P <.001) and increased bone mineral content (BMC, P <.001) as compared with feeding the control diet. Bone studies indicated that femurs and tibias from phytase supplemented rats had greater mass (P <.05) and were stronger (P <.05) than rats fed the control diet. This data suggest that the addition of phytase to low Zn diets results in improved Zn status, which may be responsible for beneficial effects on growth, body composition, and bone strength. (c) 2006 Elsevier Inc. All rights reserved. C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. Iowa State Univ Sci & Technol, Dept Anim Sci, Ames, IA 50011 USA. RP Scrimgeour, AG (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM angus.scrimgeour@us.army.mil RI McClung, James/A-1989-2009; Scrimgeour, Angus/D-6794-2013 NR 48 TC 21 Z9 22 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0955-2863 J9 J NUTR BIOCHEM JI J. Nutr. Biochem. PD MAR PY 2006 VL 17 IS 3 BP 190 EP 196 DI 10.1016/j.jnutbio.2005.07.003 PG 7 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 020SS UT WOS:000235931300006 PM 16214325 ER PT J AU Killgore, WDS Balkin, TJ Wesensten, NJ AF Killgore, WDS Balkin, TJ Wesensten, NJ TI Impaired decision making following 49 h of sleep deprivation SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE decision making; executive function; gambling; prefrontal cortex; risk taking; sleep deprivation ID VENTROMEDIAL PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; FUTURE CONSEQUENCES; DIVERGENT THINKING; PERFORMANCE; TASK; AGE; VIGILANCE; CAFFEINE; NIGHT AB Sleep deprivation reduces regional cerebral metabolism within the prefrontal cortex, the brain region most responsible for higher-order cognitive processes, including judgment and decision making. Accordingly, we hypothesized that two nights of sleep loss would impair decision making quality and lead to increased risk-taking behavior on the Iowa Gambling Task (IGT), which mimics real-world decision making under conditions of uncertainty. Thirty-four healthy participants completed the IGT at rested baseline and again following 49.5 h of sleep deprivation. At baseline, volunteers performed in a manner similar to that seen in most samples of healthy normal individuals, rapidly learning to avoid high-risk decks and selecting more frequently from advantageous low-risk decks as the game progressed. After sleep loss, however, volunteers showed a strikingly different pattern of performance. Relative to rested baseline, sleep-deprived individuals tended to choose more frequently from risky decks as the game progressed, a pattern similar to, though less severe than, previously published reports of patients with lesions to the ventromedial prefrontal cortex. Although risky decision making was not related to participant age when tested at rested baseline, age was negatively correlated with advantageous decision making on the IGT, when tested following sleep deprivation (i.e. older subjects made more risky choices). These findings suggest that cognitive functions known to be mediated by the ventromedial prefrontal cortex, including decision making under conditions of uncertainty, may be particularly vulnerable to sleep loss and that this vulnerability may become more pronounced with increased age. C1 Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM william.d.killgore@us.army.mil NR 37 TC 197 Z9 203 U1 5 U2 39 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD MAR PY 2006 VL 15 IS 1 BP 7 EP 13 DI 10.1111/j.1365-2869.2006.00487.x PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 013NU UT WOS:000235416800002 PM 16489997 ER PT J AU Probst, RJ Lim, JM Bird, DN Pole, GL Sato, AK Claybaugh, JR AF Probst, RJ Lim, JM Bird, DN Pole, GL Sato, AK Claybaugh, JR TI Gender differences in the blood volume of conscious Sprague-Dawley rats SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article AB Reference values of blood volume (BV) and plasma volume (PV) of animal species are given as functions of body weight and gender specification generally is not given. Considering the common observation of a decreased hematocrit (Hct) in the females of many species, the BV, the PV, or both must differ between genders. The present study was performed to determine the magnitude of those differences. We measured Hct and PV in 24 female and 23 male Sprague-Dawley rats in their 12th week of life. The rats were surgically prepared with indwelling femoral arterial catheters 4 d prior to the determination of BV. Evan's Blue dye dilution was used to determine PV in conscious, quietly resting animals. BV was calculated as PV/(1 - Hct). Mean Hct was 2% lower in female rats than males, and PV (mean 1 standard deviation) was 4.86 +/- 0.54 ml/100 g in females compared with 4.12 +/- 0.32 ml/100 g in males. Calculated BV in female rats was 7.84 +/- 0.70 ml/100 g compared with 6.86 +/- 0.53 ml/100 g in males. When precise estimates of BV or PV are needed for research or dosing purposes, gender differences of 18% for PV and 14% for BV must be considered. In addition, species other than the rat may have similar discrepancies between sexes, and the prudent investigator must determine individual volume assessments of both sexes before assumptions of BV and PV for a species can be made. C1 Tripler Army Med Ctr, Dept Clin Invest, Tripler, HI USA. Tripler Army Med Ctr, Dept Pediat, Tripler, HI USA. Univ Hawaii, John A Burns Sch Med, Dept Physiol, Honolulu, HI 96822 USA. RP Claybaugh, JR (reprint author), Tripler Army Med Ctr, Dept Clin Invest, Tripler, HI USA. EM john.claybaugh@amedd.army.mil FU NCRR NIH HHS [P20 RR011091, P20 RR11091, P20 RR011091-100049] NR 11 TC 41 Z9 42 U1 0 U2 5 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1060-0558 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAR PY 2006 VL 45 IS 2 BP 49 EP 52 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 029LA UT WOS:000236562700009 PM 16542044 ER PT J AU Weerasooriya, T Moy, P Casem, D Cheng, M Chen, W AF Weerasooriya, T Moy, P Casem, D Cheng, M Chen, W TI A four-point bend technique to determine dynamic fracture toughness of ceramics SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID COMPOSITES; INITIATION; SPECIMENS; BAR AB The procedure for determining quasi-static fracture toughness of ceramics has been standardized. To expand the loading rate into the dynamic region, the dynamic equilibrium over the entire specimen needs to be satistied to interpret the crack tip loading state with the far-field loading conditions. Furthermore, to determine the loading-rate effects, the loading rate at the crack tip should be nearly constant during an experiment. A new four-point bending experimental technique, based on a split Hopkinson pressure bar, has been developed to determine the dynamic fracture toughness of ceramics at high rates under valid conditions, which is demonstrated through the determination of the dynamic fracture toughness as a function of loading rate for a silicon carbide (SiC-N). C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Med Eng Syst Inc, Ottawa, ON K1G 6C4, Canada. Purdue Univ, AAE MSE Sch, W Lafayette, IN 47907 USA. RP USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM tusitw@arl.army.mil NR 22 TC 40 Z9 47 U1 2 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAR PY 2006 VL 89 IS 3 BP 990 EP 995 DI 10.1111/j.1551-2916.2005.00896.x PG 6 WC Materials Science, Ceramics SC Materials Science GA 030AY UT WOS:000236606700035 ER PT J AU Chadee, DD Wilkerson, RC AF Chadee, DD Wilkerson, RC TI Ecology of the malaria vector, Anopheles (Nyssorhynchus) marajoara Galvao and Damasceno in Trinidad, West Indies SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Anopheles marajoara; taxonomy; PCR methods; seasonal distribution; blood-feeding; Trinidad ID POLYMERASE-CHAIN-REACTION; ALBITARSIS COMPLEX; AEDES-AEGYPTI; HOST-SEEKING; DIPTERA; CULICIDAE; IDENTIFICATION; ARGENTINA; KINETICS; BRAZIL AB The taxonomy and ecology of wild-caught Anopheles marajoara mosquitoes derived from rice fields in Frederick Settlement, Trinidad, were studied in the laboratory using specimens identified with species-specific random amplified polymorphic DNA (RAPD) profiles and recently developed rDNA ITS2 polymerase chain reaction methods. Adults were collected using Shannon traps and human bait in 2 houses over a 1-year period. All mosquitoes collected were taken to the laboratory, where they were identified, wing-length measured, and parity rates determined using standard methods. In addition, 25 females were blood fed and subsequently offered a blood meal every 2 It for a 60-h period. Based on the morphological keys and molecular tools used, the presence of An. marajoara is confirmed in Trinidad for the first time. Analysis of the seasonal distribution of An. marajoara revealed that over 58% were collected during the rainy season. The wing length of 660 females measured averaged 2.90 +/- 0.130 mm, with no significant differences being observed among the parous and nulliparous females' wing sizes (2.90 and 2.92 mm, respectively). In addition, the monthly parous rate was not significantly correlated with mean wing-length over time (r = 0.157, df = 16, P > 0.07). Results from the blood feeding studies showed 85% of females blood fed immediately (hour 0) after capture in the field. However, blood feeding declined thereafter until 24 It later, when over 40% refed. This study clearly identified the presence of An. marajoara in Trinidad and provides information of the seasonal abundance and blood-feeding behaviors. These results suggest that this species can play a significant role in the transmission of malaria within its geographical range in the Neotropics. C1 Univ W Indies, Dept Life Sci, St Augustine, Trinid & Tobago. Minist Hlth, Insect Vector Control Div, St Joseph, Trinid & Tobago. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Chadee, DD (reprint author), Univ W Indies, Dept Life Sci, St Augustine, Trinid & Tobago. NR 31 TC 3 Z9 3 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2006 VL 22 IS 1 BP 22 EP 28 DI 10.2987/8756-971X(2006)22[22:EOTMVA]2.0.CO;2 PG 7 WC Entomology SC Entomology GA 027PS UT WOS:000236428100005 PM 16646317 ER PT J AU Turell, MJ Dohm, DJ Fernandez, R Calampa, C O'Guinn, ML AF Turell, MJ Dohm, DJ Fernandez, R Calampa, C O'Guinn, ML TI Vector competence of peruvian mosquitoes (Diptera : Culicidae) for a subtype IIIC virus in the Venezuelan equine encephalomyelitis complex isolated from mosquitoes captured in Peru SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Peru; Venezuelan equine encephalomyelitis virus; Mucambo virus; transmission; mosquitoes; vector competence ID CULEX MELANOCONION TAENIOPUS; VALLEY FEVER VIRUS; ENCEPHALITIS-VIRUS; ENZOOTIC STRAINS; EXPERIMENTAL INFECTION; CENTRAL-AMERICAN; SOUTH-AMERICA; DISAPPEARANCE; REGION; DISSEMINATION AB We evaluated mosquitoes collected in the Amazon Basin, near Iquitos, Peru, for their susceptibility to a subtype IIIC strain of the Venezuelan equine encephalomyelitis complex. This virus had been previously isolated from a pool of mixed Culex vomerifer and Cx. gnomatos captured near Iquitos, Peru, in 1997. After feeding on banisters with viremias of about 10(8) plaque-forming units of virus per ml, Cx. gnomatos was the most efficient vector. Other species, such as Ochlerotatus fulvus and Psorophora cingulata, although highly susceptible to infection, were not efficient laboratory vectors of this virus due to a significant salivary gland barrier. The Cx. (Culex) species, consisting mostly of Cx. (Cux.) coronator, were nearly refractory to subtype IIIC virus and exhibited both midgut infection as well as salivary gland barriers. Additional studies on biting behavior, mosquito population densities, and vertebrate reservoir hosts of subtype IIIC virus are needed to determine the role that these species play in the maintenance and spread of this virus in the Amazon Basin region. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USN, Med Res Ctr, Dept Entomol, Lima, Peru. Minist Hlth, Loreto Dept, Iquitos, Peru. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 30 TC 11 Z9 11 U1 0 U2 8 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2006 VL 22 IS 1 BP 70 EP 75 DI 10.2987/8756-971X(2006)22[70:VCOPMD]2.0.CO;2 PG 6 WC Entomology SC Entomology GA 027PS UT WOS:000236428100013 PM 16646325 ER PT J AU Hogue, MD Grabenstein, JD Foster, SL Rothholz, MC AF Hogue, Michael D. Grabenstein, John D. Foster, Stephan L. Rothholz, Mitchel C. TI Pharmacist involvement with immunizations: A decade of professional advancement SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION LA English DT Review DE vaccines; pharmacists; immunizations; public health AB Objective: To review achievements in pharmacist-administered immunizations, emphasizing the period 1995 to 2004. Data Sources: Published articles identified through PubMed (1995-2004) using the search terms pharmacist, pharmacy, and vaccine, immunization, or shots. Additional sources were identified from personal bibliographies collected by the authors during this decade, as well as the bibliographies of the retrieved articles. The later two sources resulted in manuscripts of primarily historical significance. Study Selection: More than 300 manuscripts were identified. The authors selected 15 studies that most clearly document the effect of pharmacist-administered immunizations for review. Data Extraction: By the authors. Data Synthesis: While pharmacists have been involved with vaccines dating back to the mid- 1800s and the distribution of smallpox vaccine, only 10 years have passed since pharmacists began routinely immunizing patients in their communities as a standard practice activity. The Washington State Pharmacists Association initiated the first ongoing formalized training of pharmacists in vaccine administration in 1994. On November 1, 1996, the American Pharmaceutical (now Pharmacists) Association (APhA) began its nationally recognized training program for pharmacists, Pharmacy-Based Immunization Delivery: A National Certificate Program for Pharmacists. By 2004, an estimated 15,000 pharmacists and student pharmacists had been formally trained through recognized programs as vaccine experts, and the practice of pharmacist-administered immunizations, particularly for adult patients, has become routinely accepted as an important role of the pharmacist. Arguably, few initiatives have done more to move the pharmacy profession forward in direct patient care than the pharmacist-administered immunization movement. Conclusion: Pharmacists have made significant strides in immunizations over the past decade. Limited activities in the hospital sector have been particularly well documented, as have the perceptions of patients regarding acceptance of pharmacists as immunizers. The activities of community pharmacists are less well documented. More research is needed into novel approaches to pharmacist involvement in public health-focused immunization initiatives, along with continued research evaluating the current practice of pharmacist-administered immunizations. C1 Samford Univ, McWhorter Sch Pharm, Birmingham, AL 35229 USA. USA, Surg Gen Off, Falls Church, VA USA. Univ Tennessee, Coll Pharm, Memphis, TN USA. American Pharmacists Assoc, Washington, DC USA. RP Hogue, MD (reprint author), Samford Univ, McWhorter Sch Pharm, 800 Lakeshore Dr, Birmingham, AL 35229 USA. EM mdhogue@samford.edu NR 41 TC 59 Z9 62 U1 4 U2 13 PU AMER PHARMACEUTICAL ASSOC PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 USA SN 1544-3191 J9 J AM PHARM ASSOC JI J. Am. Pharm. Assoc. PD MAR-APR PY 2006 VL 46 IS 2 BP 168 EP 182 DI 10.1331/154434506776180621 PG 15 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA V43YY UT WOS:000202971600009 PM 16602227 ER PT J AU Watson, S AF Watson, S TI A proper sense of honor: Service and sacrifice in George Washington's army. SO JOURNAL OF THE EARLY REPUBLIC LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC HISTORIANS EARLY AMERICAN REPUBLIC PI W LAFAYETTE PA PURDUE UNIV, 1358 UNIV HALL, W LAFAYETTE, IN 47907-1358 USA SN 0275-1275 J9 J EARLY REPUBL JI J. Early Repub. PD SPR PY 2006 VL 26 IS 1 BP 122 EP 125 DI 10.1353/jer.2006.0020 PG 4 WC History SC History GA 047QA UT WOS:000237892600006 ER PT J AU McPherson, JJ Feigin, DS Bellamy, RF AF McPherson, JJ Feigin, DS Bellamy, RF TI Prevalence of tension pneumothorax in fatally wounded combat casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 26th Annual Gary P Wratten Army Surgical Symposium CY APR 19, 2004 CL Washington, DC DE tension pneumothorax; penetrating chest wound; thoracentesis; trauma AB Background: Tension pneumothorax is a potential cause of death in victims of penetrating chest trauma, but little is known about its actual prevalence. Methods: Data that are part of the Vietnam Wound Data and Munitions Effectiveness Team study were analyzed to address this question. Radiographs of 978 casualties were examined for evidence of tension pneumothorax using standard radiologic criteria such as pleural separation, displacement of the mediastinum and diaphragm, trachea deviation, and compression of the contralateral lung Results: Some or all of the radiographic changes were found in 198 casualties. Autopsy evidence indicated that 79 of these casualties died solely due to a chest wound. The fatal chest injury involved only the lungs in 55 casualties and caused a tension pneumothorax in 26. Fifteen of the 26 lived long enough to receive first aid from a medic or corps-man. Conclusion: Tension pneumothorax was the cause of death in 3 to 4% of fatally wounded combat casualties. Some may be temporarily helped by battlefield thoracentesis. C1 Uniformed Serv Univ Hlth Sci, Dept Mil Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Emergency Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Bellamy, RF (reprint author), Walter Reed Army Med Ctr, Borden Inst, Delano Hall,Bldg 11,Rm 1-117,6900 Georgia Ave NW, Washington, DC 20307 USA. EM ronald.bellamy@verizon.net NR 12 TC 32 Z9 34 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 2006 VL 60 IS 3 BP 573 EP 578 DI 10.1097/01.ta.0000209179.79946.92 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 026WX UT WOS:000236374900024 PM 16531856 ER PT J AU Wedmore, I McManus, JG Pusateri, AE Holcomb, JB AF Wedmore, I McManus, JG Pusateri, AE Holcomb, JB TI A special report on the chitosan-based hemostatic dressing: Experience in current combat operations SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE HemCon; chitosan; hemorrhage control; hemostatic dressing; military ID LINGUAL HEMOSTASIS; DEACETYLATED CHITIN; VENOUS HEMORRHAGE; HEPATIC-INJURY; MODEL; SWINE; RABBITS; SURVIVAL; AGENT AB Background: Hemorrhage remains a leading cause of death in both civilian and military trauma patients. The Hem-Con chitosan-based hemostatic dressing is approved by the US Food and Drug Administration (FDA) for hemorrhage control. Animal data have shown the HemCon dressing to reduce hemorrhage and improve survival. The purpose of this article is to report preliminary results of the hemostatic efficacy of the HemCon dressing used in the prehospital setting on combat casualties. Methods: A request for case information on use of HemCon dressings in Operation Iraqi Freedom and Operation Enduring Freedom was sent to deployed Special Forces combat medics, physicians, and physician assistants. Results: Sixty-eight uses of the HemCon dressing were reported and reviewed by two US Army physicians. Four of the 68 cases were determined duplicative resulting in a total of 64 combat uses. Dressings were utilized externally on the chest, groin, buttock, and abdomen in 25 cases; on extremities in 35 cases; and on neck or facial wounds in 4 cases. In 66% of cases, dressings were utilized following gauze failure and were 100% successful. In 62 (97%) of the cases, the use of the HemCon dressing resulted in cessation of bleeding or improvement in hemostasis. There were two reported dressing failures that occurred with blind application of bandages up into large cavitational injuries. Dressings were reported to be most useful on areas where tourniquets could not be applied to control bleeding. The dressings were reported to be most dffficult to use in extremity injuries where they could not be placed easily onto or into the wounds. No complications or adverse events were reported. Conclusion: This report on the field use of the HemCon dressing by medics suggests that it is a useful hemostatic dressing for prehospital combat casualties and supports further study to confirm efficacy. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Madigan Army Med Ctr, Ft Lewis, WA USA. RP McManus, JG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 17 TC 248 Z9 262 U1 10 U2 63 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 2006 VL 60 IS 3 BP 655 EP 658 DI 10.1097/01.ta.0000199392.91772.44 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 026WX UT WOS:000236374900043 PM 16531872 ER PT J AU Pusateri, AE Holcomb, JB Kheirabadi, BS Alam, HB Wade, CE Ryan, KL AF Pusateri, AE Holcomb, JB Kheirabadi, BS Alam, HB Wade, CE Ryan, KL TI Making sense of the preclinical literature on advanced hemostatic products SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE hemostatic dressings; hemorrhage control; trauma ID N-ACETYL GLUCOSAMINE; FIBRIN SEALANT DRESSINGS; REDUCE BLOOD-LOSS; V LIVER-INJURIES; HEMORRHAGE CONTROL; ACHIEVING HEMOSTASIS; SPLENIC HEMORRHAGE; VENOUS HEMORRHAGE; ADHESIVE BANDAGE; HEPATIC-INJURY AB A number of new hemostatic products have been developed recently for use in trauma settings of severe uncontrolled bleeding. Currently, the literature on these products is controversial, with efficacy demonstrated under some circumstances but not others. In this review, we analyze the current literature pertaining to four of the most promising products (dry fibrin sealant dressing, Rapid Deployment Hemostat, HemCon chitosan dressing, and QuikClot) that have been suggested for use in combat casualty care applications. In particular, this analysis takes into account the characteristics of the animal models used for efficacy testing of these products, the desired characteristics of hemostatic dressings, and specific safety considerations. Animal models ranged from those featuring low-pressure/ low-flow bleeding to those featuring high-pressure/high-flow bleeding. When data are viewed in the context of the specific characteristics of the differing animal models used, seemingly disparate experimental results related to efficacy and safety become quite complementary and lead to recommendations for the use of different products in different injury scenarios. Mission and training requirements will dictate the use of these products by military and civilian prehospital care providers. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Pusateri, AE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM anthony.pusateri@amedd.army.mil NR 39 TC 114 Z9 122 U1 4 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 2006 VL 60 IS 3 BP 674 EP 682 DI 10.1097/01.ta.0000196672.47783.fd PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 026WX UT WOS:000236374900047 PM 16531876 ER PT J AU Morey, AF Medendorp, AR Noller, MW Mora, RV Shandera, KC Foley, JP Rivera, LR Reyna, JA Terry, PJ AF Morey, AF Medendorp, AR Noller, MW Mora, RV Shandera, KC Foley, JP Rivera, LR Reyna, JA Terry, PJ TI Transobturator versus transabdominal mid urethral slings: A multi-institutional comparison of obstructive voiding complications SO JOURNAL OF UROLOGY LA English DT Article DE urinary incontinence; urinary retention; urinary catheterization; surgery ID FREE VAGINAL TAPE; STRESS URINARY-INCONTINENCE; RETENTION; SURGERY; EROSION; TRIAL AB Purpose: In the last year TO slings have become an increasingly popular alternative to TA slings for the surgical treatment of SUI. Proposed advantages of the transobturator approach include improved speed, safety and the reduction of obstructive complications. We assessed outcomes of TO and TA slings in a large series of women treated at several institutions to compare the rate of obstructive complications from these procedures. Materials and Methods: We reviewed the charts of 504 consecutive women who had synthetic mid urethral sling procedures (154 TO or 350 TA) performed by 24 different urologists for SUI at 8 institutions from 2002 to 2004. Obstructive complications were defined as increased PVR (greater than 100 cc), or the need for CIC, prolonged Foley catheter drainage or urethrolysis. Results: While TO and TA sling procedures appeared to be similarly efficacious in eliminating the need for incontinence pad use (TO 89%, TA 86%, p = 0.36), the transobturator approach was associated with fewer obstructive complications (TO 11.0%, TA 18.3%, p <0.05). Urethrolysis was required in none of the 154 TO cases and 8 of 350 (2.3%) TA cases. Concomitant pelvic surgery did not significantly increase the likelihood of obstructive voiding complications in either group. Conclusions: Although TO and TA sling procedures had similar short-term results for decreasing pad use in patients with stress urinary incontinence, the transobturator approach is associated with fewer obstructive voiding complications. C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. Urol San Antonio, San Antonio, TX USA. Urol Specialists Carolinas, Charlotte, NC USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Allen.morey@amedd.army.mil NR 19 TC 28 Z9 29 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 2006 VL 175 IS 3 BP 1014 EP 1017 DI 10.1016/S0022-5347(05)00412-X PN 1 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 011SW UT WOS:000235289400054 PM 16469607 ER PT J AU Palekar, NA Naus, R Larson, SP Ward, J Harrison, SA AF Palekar, NA Naus, R Larson, SP Ward, J Harrison, SA TI Clinical model for distinguishing nonalcoholic steatohepatitis from simple steatosis in patients with nonalcoholic fatty liver disease SO LIVER INTERNATIONAL LA English DT Article DE clinical characteristics; composite index; NAFLD; NASH; serologic markers ID LIPID-PEROXIDATION; OXIDATIVE STRESS; SEVERELY OBESE; FIBROSIS; NASH; ADIPONECTIN; PREDICTORS; PATHOLOGY; SEVERITY; ALPHA AB Nonalcoholic fatty liver disease (NAFLD) encompasses both simple steatosis and nonalcoholic steatohepatitis (NASH). Differentiation of these two entities requires histopathologic evaluation. The aim of this study was to establish a reliable diagnostic model for differentiating steatosis from steatohepatitis utilizing both clinical characteristics and a panel of biochemical markers of lipid peroxidation and fibrosis. Eighty subjects with biopsy proven NAFLD were enrolled, 39 with simple steatosis and 41 with histopathologic evidence of NASH. Demographic and laboratory data to include serologic testing for 8-epi-PGF(2 alpha), transforming growth factor-beta (TGF-beta), adiponectin, and hyaluronic acid (HA) were obtained and compared between the two groups. There were significant differences between the two groups with respect to age (P=0.004), female gender (P=0.024), aspartate aminotransferase (AST) (P=0.028), body mass index (BMI) (P=0.003), fasting insulin (0.018), AST/alanine aminotransferase (ALT) ratio (AAR) (P=0.017), quantitative insulin sensitivity check index (QUICKI) (P=0.002), and HA (P=0.029). A composite index for distinguishing steatosis from NASH was calculated by summing the risk factors of age >= 50 years, female gender, AST >= 45 IU/l, BMI >= 30 mg/kg(2), AAR >= 0.80, and HA >= 55 mcg/l, and its accuracy was determined by receiver operating characteristic (ROC) analysis to be 0.763 (95% CI: 0.650-0.876). The presence of three or more risk factors had a sensitivity, specificity, PPV, and NPV of 73.7%, 65.7%, 68.2%, and 71.4%, respectively. In addition, HA at a cutoff of 45.3 mcg/l was a good predictor of advanced fibrosis. In conclusion, we propose a noninvasive screening model for distinguishing simple steatosis from NASH. Identifying patients at risk for NASH will allow clinicians to more accurately determine who may benefit from liver biopsy. C1 Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Dept Clin Invest, Ft Sam Houston, TX USA. RP Harrison, SA (reprint author), 1506 Palmer View, San Antonio, TX 78258 USA. EM Stephen.Harrison@cen.amedd.army.mil NR 23 TC 106 Z9 110 U1 0 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1478-3223 J9 LIVER INT JI Liver Int. PD MAR PY 2006 VL 26 IS 2 BP 151 EP 156 DI 10.1111/j.1478-3231.2005.01209.x PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 008MP UT WOS:000235045200001 PM 16448452 ER PT J AU Fan, C Kecskes, L Jiao, T Choo, H Inoue, A Liaw, P AF Fan, Cang Kecskes, Laszlo Jiao, Tong Choo, Hahn Inoue, Akihisa Liaw, Peter TI Shear-band deformation in amorphous alloys and composites SO MATERIALS TRANSACTIONS LA English DT Article DE bulk metallic glasses; shear bands; structures; composites; deformation ID METALLIC GLASSES; EVOLUTION AB The deformation of monolithic bulk-metallic glasses (BMGs), nanocrystal-containing, and micrometer-sized, ductile-particle-reinforced bulk metallic glass composites (BMGCs) has been investigated. The number density of shear bands, the interaction of shear bands with the particles, as well as the apparent plasticity was found to be significantly different in three types of samples before failure occurred. The interaction of shear bands with the micrometer-sized particles implied that shear bands can be initiated by stress concentration at the particle boundaries and, at the same time, absorbed by the deformation of particles. It is hypothesized that the observed number density and motion of shear bands could arise from the interaction of rotational sliding of medium range order (MRO) or dense-packed clusters, fine crystals, and the free volume in the material. An estimate of the shear band thickness, based on the size of particles or grains near and in the shear bands of the BMGs, BMGCs, and ultra-fine structured materials is consistent with this conjecture. C1 Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37916 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Brown Univ, Div Engn, Providence, RI 02912 USA. Oak Ridge Natl Lab, Div Met & Ceram, Oak Ridge, TN 37831 USA. Tohoku Univ, Mat Res Inst, Sendai, Miyagi 9808577, Japan. RP Fan, C (reprint author), Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37916 USA. RI Choo, Hahn/A-5494-2009; Kecskes, Laszlo/F-6880-2014; Inoue, Akihisa/E-5271-2015 OI Choo, Hahn/0000-0002-8006-8907; Kecskes, Laszlo/0000-0002-1342-3729; NR 15 TC 9 Z9 9 U1 1 U2 6 PU JAPAN INST METALS PI SENDAI PA 1-14-32, ICHIBANCHO, AOBA-KU, SENDAI, 980-8544, JAPAN SN 1345-9678 EI 1347-5320 J9 MATER TRANS JI Mater. Trans. PD MAR PY 2006 VL 47 IS 3 BP 817 EP 821 DI 10.2320/matertrans.47.817 PG 5 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 046CS UT WOS:000237789600069 ER PT J AU Jangpatarapongsa, K Sirichaisinthop, J Sattabongkot, J Cui, LW Montgomery, SM Looareesuwan, S Troye-Blomberg, M Udomsangpetch, R AF Jangpatarapongsa, K Sirichaisinthop, J Sattabongkot, J Cui, LW Montgomery, SM Looareesuwan, S Troye-Blomberg, M Udomsangpetch, R TI Memory T cells protect against Plasmodium vivax infection SO MICROBES AND INFECTION LA English DT Article DE malaria; Plasmodium vivax; memory T cells; gamma delta T cells ID FALCIPARUM SPOROZOITES; IMMUNOLOGICAL MEMORY; MALARIA; LYMPHOCYTES; MAINTENANCE; IMMUNITY; CULTURE; BLOOD; CD27 AB immunity induced by Plasmodium vivax infection leads to memory T cell recruitment activated during "relapse" or "re-infection". This study aims to characterise memory T cells in patients with acute or convalescent P. vivax infection. Lymphocytes were collected from patients infected by P. vivax, immune controls and naive controls. The proportion of immature memory T cells, expressing CD45RO(+)CD27(+), and mature cells lacking CD27 was assessed. A statistically significant increase in the median percentage of memory T cell subsets expressing CD4(+) was observed in material from patients with an acute infection compared with that from either native or immune controls. The high percentage of memory T cells in infected patients was maintained until 60 days post treatment. The immune controls living in a malaria endemic area had a somewhat increased proportion of memory T cell subsets expressing CD8(+). An approximately three-fold increase of these cell types was shown in patients with an acute infection and the level persisted until 60 days post treatment. Phenotypic characterisation of the peripheral lymphocytes during acute infection revealed that a large fraction of the lymphocytes carried the gamma delta phenotypes suggesting a role for these cells in the early response against P. vivax. Very low levels of P. vivax specific antibody were found. This might suggest that cell-mediated immunity may play a greater role in the development of naturally acquired protection against P. vivax infection than humoral immunity. Our results provide further insight into the mechanism of cell-mediated immunity to P. vivax infection that could be important for the future development of a successful vaccine and anti-malarial drug designation. (c) 2006 Elsevier SAS. All rights reserved. C1 Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. Mahidol Univ, Fac Med Technol, Dept Parasitol, Bangkok 10700, Thailand. Minist Publ Hlth, Ctr Malaria Res & Training, Sara Buri 18120, Thailand. USA Mil Component, Dept Entomol, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. Karolinska Univ Hosp, Dept Med, Clin Epidemiol Unit, SE-17176 Stockholm, Sweden. Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand. Stockholm Univ, Wenner Gren Inst, Dept Immunol, SE-10691 Stockholm, Sweden. RP Udomsangpetch, R (reprint author), Mahidol Univ, Fac Sci, Dept Pathobiol, Rama VI Rd, Bangkok 10400, Thailand. EM scrud@mahidol.ac.th RI Troye-Blomberg, Marita/B-9210-2016; OI Troye-Blomberg, Marita/0000-0002-2804-0325; Montgomery, Scott/0000-0001-6328-5494 NR 21 TC 18 Z9 20 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 J9 MICROBES INFECT JI Microbes Infect. PD MAR PY 2006 VL 8 IS 3 BP 680 EP 686 DI 10.1016/j.micinf.2005.09.003 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 045PL UT WOS:000237754000012 PM 16469520 ER PT J AU Byrd, W Cassels, FJ AF Byrd, W Cassels, FJ TI The encapsulation of enterotoxigenic Escherichia coli colonization factor CS3 in biodegradable microspheres enhances the murine antibody response following intranasal administration SO MICROBIOLOGY-SGM LA English DT Article ID HEAT-LABILE ENTEROTOXIN; NEUTRALIZING ANTIBODIES; MUCOSAL ADJUVANTICITY; VACCINE DEVELOPMENT; RESPIRATORY-TRACT; IMMUNOGLOBULIN-A; SUBUNIT VACCINES; IMMUNIZATION; CHOLERA; NASAL AB The aim of this study was to measure serum and mucosal antibody responses following intranasal administration of biodegradable poly(DL-lactide-co-glycolide) (PLGA) microspheres loaded with the CS3 colonization factor isolated from enterotoxigenic Escherichia coli (ETEC). The response was compared against that measured in mice similarly administered the native CS3 antigen and in mice co-administered, along with the CS3 antigen, a known mucosal adjuvant, the R192G mutant heat-labile enterotoxin (mLT). The integrity of the CS3 antigen released from the microspheres was maintained as determined by SIDS-PAGE and immunoblotting. Native CS3 induced serum and mucosal (bronchoalveolar, small intestinal and faecal) IgG and IgA responses. The co-administration of the mLT mucosal adjuvant significantly enhanced (P<0.001) serum and mucosal antibody responses to the CS3 protein. Likewise, the CS3-loaded PLGA microspheres induced significantly greater (P<0.001) serum and mucosal antibody responses than native CS3, as well as inducing antibody responses superior to those of the CS3 plus mLT formulation. Following administration of CS3 plus mLT, the mice became distressed (loss of activity, increased huddling, ruffled fur), a situation not seen following administration of the CS3-loaded PLGA microspheres. The results in this trial show that the CS3-loaded PLGA microspheres when administered intranasally to mice caused no observable distress to the mice and significantly (P<0.001) enhanced the immunogenicity of the CS3 protein. C1 Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD 20910 USA. RP Byrd, W (reprint author), Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD 20910 USA. EM dagmarbyrd@comcast.net NR 46 TC 3 Z9 3 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD MAR PY 2006 VL 152 BP 779 EP 786 DI 10.1099/mic.0.28667-0 PN 3 PG 8 WC Microbiology SC Microbiology GA 026EY UT WOS:000236321700020 PM 16514157 ER PT J AU Long, J AF Long, Julie TI What remedy for abused Iraqi detainees? SO MILITARY LAW REVIEW LA English DT Article ID CONVENTION; LAW C1 Stuttgart Law Ctr, Theater Support Command 21st, Stuttgart, Germany. USA, Judge Advocate Gen Sch, Legal Ctr, Charlottesville, VA 22901 USA. Univ Minnesota, Hubert H Humphrey Inst Publ Affairs, Minneapolis, MN 55455 USA. Bowling Green State Univ, Bowling Green, OH 43403 USA. RP Long, J (reprint author), Stuttgart Law Ctr, Theater Support Command 21st, Stuttgart, Germany. NR 31 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2006 VL 187 BP 43 EP 95 PG 53 WC Law SC Government & Law GA 076EW UT WOS:000239940800002 ER PT J AU Schiffer, EC AF Schiffer, Emily C. TI Becoming Justice Blackmun: Harry Blackmun's Supreme Court journey SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Legal Ctr, Charlottesville, VA 22901 USA. RP Schiffer, EC (reprint author), USA, Judge Advocate Gen Sch, Legal Ctr, Charlottesville, VA 22901 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2006 VL 187 BP 174 EP 183 PG 10 WC Law SC Government & Law GA 076EW UT WOS:000239940800004 ER PT J AU Parrella, KA AF Parrella, Keith A. TI America's splendid little wars: A short history of US engagements from the fall of Saigon to Baghdad SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Legal Ctr, Charlottesville, VA 22901 USA. RP Parrella, KA (reprint author), USA, Judge Advocate Gen Sch, Legal Ctr, Charlottesville, VA 22901 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2006 VL 187 BP 184 EP 192 PG 9 WC Law SC Government & Law GA 076EW UT WOS:000239940800005 ER PT J AU Marin, R AF Marin, R TI Physical medicine and rehabilitation in the military: Operation Iraqi Freedom SO MILITARY MEDICINE LA English DT Article ID INJURY; CASUALTIES; WAR AB This article describes the role of a physical medicine and rehabilitation (physiatry) physician (physiatrist) as a general medical officer within a forward support battalion during the invasion and nation-building phases of Operation Iraqi Freedom. Between March 10 and May 3, 2003 (invasion phase), 364 patients were evaluated. Thirty-two percent had musculoskeletal noncombat injuries, 9% had combat-related traumatic injuries, and the remaining 59% had nontrauma/nonmusculoskeletal conditions. Between May 4 and July 25, 2003 (nation-building phase), 1,387 patients were evaluated. Of these, 19% had musculoskeletal injuries, 1% had combat-related traumatic injuries, and the remaining 80% had nontrauma/nonmusculoskeletal conditions. During this nation-building phase, the musculoskeletal workload seen at the division-level combat support hospital was 4 times the workload seen in the forward support battalion. This experience underscores the role of physiatry in wartime casualty management and profiles the combat support hospital as the most suitable place for the physiatrist during wartime. Interventions focused on acute management and rehabilitation counseling for all musculoskeletal injuries, as well as consultation services to the combat support hospital and local civilian hospitals for the evaluation of complex neuromusculoskeletal trauma cases. C1 Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Phys Med & Rehabil Serv, Washington, DC 20307 USA. RP Marin, R (reprint author), 20009 Manor View Terrace, Laytonville, MD 20882 USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 185 EP 188 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500002 PM 16602511 ER PT J AU Beitler, AL Wortmann, GW Hofmann, LJ Goff, JM AF Beitler, AL Wortmann, GW Hofmann, LJ Goff, JM TI Operation Enduring Freedom: The 48th Combat Support Hospital in Afghanistan SO MILITARY MEDICINE LA English DT Article AB Objective: To examine the experience of the 48th Combat Support Hospital (CSH) while deployed to Afghanistan, with an emphasis on trauma care. Materials and Methods: Before redeployment, a retrospective review was performed on the medical records of all patients treated at the 48th CSH from December 6, 2002 through June 7, 2003. Results: During the 6-month period, 10,679 patients were evaluated and/or treated. There were 477 hospital admissions (adults, 387; children, 90; trauma, 204) and 634 operating room procedures. The most common mechanisms of injury were land mines/unexploded ordinance (74 = 36%) and gunshot wounds (41 = 20%). Extremities were the most common site. A total of 358 cases was performed on 168 trauma patients (mean, 2 cases per patient; range, 1-12). There were 63 complications in 40 trauma patients and 11 patients died. Conclusions: The 48th CSH supported military and humanitarian operations with an ongoing process of re-evaluation, adaptation, and medical education that resulted in low morbidity and mortality rates. C1 Dept Vet Affairs New Jersey Healthcare Syst, Dept Surg, E Orange, NJ 07018 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Philadelphia Coll Osteopath Med, Philadelphia, PA 19131 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Beitler, AL (reprint author), Dept Vet Affairs New Jersey Healthcare Syst, Dept Surg, E Orange, NJ 07018 USA. EM Alan.Beider@med.va.gov NR 4 TC 26 Z9 29 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 189 EP 193 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500003 PM 16602512 ER PT J AU Harcke, HT Statler, JD Montilla, J AF Harcke, HT Statler, JD Montilla, J TI Radiology in a hostile environment: Experience in Afghanistan SO MILITARY MEDICINE LA English DT Article ID TRAUMA AB Imaging equipment deployed with the combat support hospital in Afghanistan represented new technology not previously used in a hostile environment for a prolonged period. In general, the equipment performed well in a stationary locatio Having computed tomography and ultrasound scans, in addition to plain radiographs, was very helpful for patient care. Redundancy of digital radiography and ultrasound systems proved prudent. It is recommended that a radiologist continue to be sent with the combat support hospital, particularly when computed tomography and ultrasound systems are in the deployment package. This report acquaints the medical community with information to aid in the planning and performance of future deployments that bring digital imaging to the battlespace. C1 Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. Madigan Army Med Ctr, Dept Radiol, Tacoma, WA 98431 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Harcke, HT (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. NR 5 TC 11 Z9 11 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 194 EP 199 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500004 PM 16602513 ER PT J AU Javernick, MA Doukas, WC AF Javernick, MA Doukas, WC TI Process of care for battle casualties at Walter Reed Army Medical Center: Part I. Orthopedic surgery service SO MILITARY MEDICINE LA English DT Article AB Walter Reed Army Medical Center has been a primary hub in the United States for receiving Army battle casualties from Operation Enduring Freedom and Operation Iraqi Freedom. We detail the process of care that was developed to effect the timely effective management of these casualties. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Javernick, MA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 200 EP 202 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500005 PM 16602514 ER PT J AU Springer, BA Doukas, WC AF Springer, BA Doukas, WC TI Process of care for battle casualties at Walter Reed Army Medical Center: Part II. Physical therapy service SO MILITARY MEDICINE LA English DT Article AB Physical therapists, physical therapy assistants, and physical therapy technicians provide care to soldiers, sailors, Marines, and airmen returning from Operation Enduring Freedom and Operation Iraqi Freedom. We describe the inpatient and outpatient services provided, the problems and solutions encountered, and the lessons learned at the beginning of the war. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Springer, BA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 203 EP 205 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500006 PM 16602515 ER PT J AU Pasquina, PF Gambel, J Foster, LS Kim, A Doukas, WC AF Pasquina, PF Gambel, J Foster, LS Kim, A Doukas, WC TI Process of care for battle casualties at the Walter Reed Army Medical Center: Part III. Physical medicine and rehabilitation service SO MILITARY MEDICINE LA English DT Article AB The Physical Medicine and Rehabilitation Service provides a critical role in the assessment, management, and disposition of the newly injured combatant. This role has been well demonstrated during Operation Enduring Freedom and Operation Iraqi Freedom. Military physiatrists are uniquely suited to support military service members as they maximize their function and either return to duty or transition to civilian life. C1 Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. RP Pasquina, PF (reprint author), Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 206 EP 208 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500007 PM 16602516 ER PT J AU Howard, WJ Doukas, WC AF Howard, WJ Doukas, WC TI Process of care for battle casualties at Walter Reed Army Medical Center: Part IV. Occupational therapy service SO MILITARY MEDICINE LA English DT Article AB Occupational therapy addresses deficits in activities of daily living, upper-extremity motor performance deficits secondary to injury or disease, and occupational or role performance deficits attributable to mental and behavioral health conditions. We describe the inpatient and outpatient services provided, the problems and solutions encountered, and the lessons learned. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Howard, WJ (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 209 EP 210 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500008 PM 16602517 ER PT J AU Malish, R DeVine, JG AF Malish, R DeVine, JG TI Delayed drop zone evacuation: Execution of the medical plan for an airborne operation into Northern Iraq SO MILITARY MEDICINE LA English DT Article AB Flying directly from its home station in Vicenza, Italy, the 173rd Airborne Brigade committed itself to the invasion of Iraq on the night of March 26, 2003. Representing the establishment of a northern front, similar to 1,000 paratroopers jumped into an isolated valley on a mission to secure and to hold the Bashur airstrip. This article describes the unique challenges of medical preparation for the mission, injuries sustained on the jump, and lessons learned. Emphasis is placed on the use of a policy of delayed evacuation until clarification of diagnosis. C1 Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. Madigan Army Med Ctr, Orthoped Surg Serv, Tacoma, WA 98431 USA. RP Malish, R (reprint author), Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 224 EP 227 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500012 PM 16602521 ER PT J AU Killgore, WDS Vo, AH Castro, CA Hoge, CW AF Killgore, WDS Vo, AH Castro, CA Hoge, CW TI Assessing risk propensity in American soldiers: Preliminary reliability and validity of the evaluation of risks (EVAR) scale - English version SO MILITARY MEDICINE LA English DT Article AB Risk-taking propensity is a critical component of judgment and decision-making in military operations. The Evaluation of Risks scale (EVAR) was recently developed to measure state and trait aspects of risk proneness. The scale, however, was psychometrically normed in French and no data are available for the English translation. We administered the English version of the EVAR to 165 U.S. soldiers to obtain reliability, validity, and normative data for English-speaking respondents. Confirmatory factor analysis suggested that the factor structure of the English EVAR differs from that obtained in the French studies. Instead, a three-factor solution, including recklessness/impulsivity, self-confidence, and need for control, emerged. Internal consistency was comparable to the French version. EVAR scores correlated with age, military rank, and years of service, and discriminated soldiers with histories of high-risk behavior. The data support the reliability and validity of the English version of the EVAR for evaluating risk propensity in U.S. soldiers. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. OI Killgore, William/0000-0002-5328-0208 NR 13 TC 22 Z9 22 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 233 EP 239 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500014 PM 16602523 ER PT J AU Hughes, JR Miller, MA Farr, WD Hughes, TM AF Hughes, JR Miller, MA Farr, WD Hughes, TM TI Survey of US army commanders' experiences with brigade/battalion surgeons at Fort Hood, Texas SO MILITARY MEDICINE LA English DT Article ID PRACTICE RESIDENCY PROGRAMS; MEDICINE TOPICS TAUGHT; EXTENT AB This anonymous survey sent to every battalion and brigade commander at Fort Hood, Texas assessed the new concept of residency-trained operational physicians that had completed military unique curriculum series training. Commanders provided anonymous professional information about themselves and their assigned physicians and evaluated their physicians in 22 areas of medical and military competence using a linear scoring method from 2 (indicating poor) to 6 (indicating outstanding). Main effects and interaction effects were analyzed using multiple analysis of variance. The commanders' overall confidence in their physicians was 5.4, suggesting general satisfaction. Prior-service physicians were rated higher on several factors if the commander had combat experience. Nonprior-service physicians were rated the same on nearly all variables regardless of the commander's experience. Commanders with combat experience rated their assigned physicians significantly higher than did commanders without combat experience. Despite high ratings, several candid remarks suggest there is still room for improvement. C1 Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. Darnall Army Community Hosp, Dept Emergency Med, Ft Hood, TX 76544 USA. ATTN AOMD, USA Special Operat Command, Ft Bragg, NC 28310 USA. Wilford Hall USAF Med Ctr, Dept Psychol, Lackland AFB, TX 78236 USA. RP Hughes, JR (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 240 EP 245 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500015 PM 16602524 ER PT J AU Vasterling, JJ Proctor, SP Amoroso, P Kane, R Gackstetter, G Ryan, MAK Friedman, MJ AF Vasterling, JJ Proctor, SP Amoroso, P Kane, R Gackstetter, G Ryan, MAK Friedman, MJ TI The neurocognition deployment health study: A prospective cohort study of army soldiers SO MILITARY MEDICINE LA English DT Article ID GULF-WAR VETERANS; POSTTRAUMATIC-STRESS-DISORDER; POPULATION-BASED SURVEY; DESERT-STORM VETERANS; PERSIAN-GULF; COGNITIVE PERFORMANCE; MILITARY PERSONNEL; COMBAT VETERANS; ERA VETERANS; SLEEP LOSS AB Questions remain regarding the effects of military operational deployment on health. The Neurocognition Deployment Health Study addresses several gaps in the deployment health literature, including lack of baseline health data, reliance on subjective measures of exposure and health variables, prolonged intervals between redeployment and health assessments, and lack of a uniform case definition. The Neurocognition Deployment Health Study uses a prospective cohort design to assess neuropsychological outcomes associated with Iraq deployment. Methods incorporate administration of performance-based neuropsychological measures to Army soldiers before and after Iraq deployment and to nondeployed Army Soldiers assessed during comparable periods of garrison duty. Findings should have the potential to delineate neuropsychological outcomes related to combat theater deployment and to identify potential risk and protective factors related to health outcomes. C1 Vet Affairs Med Ctr, New Orleans, LA 70112 USA. Tulane Univ, Sch Med, Dept Psychiat & Neurol, New Orleans, LA 70112 USA. Vet Affairs Boston Healthcare Syst, Boston, MA 02130 USA. Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Baltimore Vet Affairs Med Ctr, Vet Affairs Maryland Hlth Care Syst, Baltimore, MD 21201 USA. Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. USN, Hlth Res Ctr, San Diego, CA USA. Dartmouth Coll Sch Med, Hanover, NH 03755 USA. Natl Ctr PTSD, Dept Vet Affairs, White River Jct, VT 05001 USA. RP Vasterling, JJ (reprint author), Vet Affairs Med Ctr, New Orleans, LA 70112 USA. NR 94 TC 20 Z9 20 U1 1 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2006 VL 171 IS 3 BP 253 EP 260 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 022II UT WOS:000236048500017 PM 16602526 ER PT J AU Royaee, AR Hammamieh, R Mendis, C Das, R Jett, M Yang, DCH AF Royaee, AR Hammamieh, R Mendis, C Das, R Jett, M Yang, DCH TI Induction of immunomodulator transcriptional responses by cholera toxin SO MOLECULAR IMMUNOLOGY LA English DT Article DE cholera toxin; gene expression; transcription; adjuvant; inflammation; cDNA arrays; cAMP; IL-8; VEGF; RT-PCR; real time PCR ID ADJUVANT; MUCOSAL; ENTEROTOXINS; EXPRESSION; CELLS; MICE; INTERLEUKIN-8; ANTIGENS; GENE; IL-1 AB Cholera toxin (CT) is the causative agent of cholera, binds to GM1 glycosphingolipids, induces the production of cellular cAMP and is also a very powerful mucosal adjuvant. Although the mechanism of the CT induction of cAMP production is well understood, molecular mechanisms of the adjuvanticity of cholera toxin are yet to be delineated. Here, we examined the interaction of CT with human lymphocytes and monocytes by analyzing the host transcriptional profiles using cDNA arrays. The time courses of the transcriptional activations and repressions of affected genes in lymphocytes and monocytes in response to cholera toxin were determined. CT induced the expression of IL-8 and MIP-1 early in the CT exposure. VEGF, TIMP1, HIF-1 alpha, MMP11, hek 8, MCPI, IL-6, GCP 2, urokinase plasminogen activator, and TNF-alpha receptor were upregulated after 4 h CT treatment. These genes showed increased expression for 48 h. MRP-14, MRP-8A increased expression after 16 h CT treatment. RT-PCR and real-time PCR using cDNA specific primers confirmed the CT induction and repression of selected genes. The results suggest that immunomodulatory genes were among the genes that were affected the most by CT, and induction of these genes may contribute to the CT adjuvanticity. (C) 2005 Elsevier Ltd. All rights reserved. C1 Georgetown Univ, Dept Chem, Washington, DC 20057 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. RP Yang, DCH (reprint author), Georgetown Univ, Dept Chem, 654 Reiss Sci Bldg, Washington, DC 20057 USA. EM yangdc@georgetown.edu RI Yang, David/A-7294-2009 NR 29 TC 6 Z9 9 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD MAR PY 2006 VL 43 IS 7 BP 1020 EP 1028 DI 10.1016/j.molimm.2005.05.008 PG 9 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 013UM UT WOS:000235435300026 PM 16023726 ER PT J AU Royaee, AR Jong, L Mendis, C Das, R Jett, M Yang, DCH AF Royaee, AR Jong, L Mendis, C Das, R Jett, M Yang, DCH TI Cholera toxin induced novel genes in human lymphocytes and monocytes SO MOLECULAR IMMUNOLOGY LA English DT Article DE cholera toxin; novel genes; mRNA; differential display; adjuvant; VEGF; interleukins; cAMP; cDNA arrays ID TRANSCRIPTIONAL RESPONSES; DIFFERENTIAL DISPLAY; MUCOSAL ADJUVANTS; EPITHELIAL-CELLS; EXPRESSION; ENTEROTOXINS; BIOLOGY; DNA AB Cholera toxin (CT) is well known as an inducer of the accumulation of cellular cAMP through the ADP-ribosylation of the Gs protein by CT. CT is also one of the most powerful mucosal adjuvants. However, the molecular mechanisms of the CT adjuvanticity are not well understood. Here, the transcriptional responses of cultured human lymphocytes and monocytes in response to CT were analyzed using differential display-PCR. The full complement of cellular mRNA was examined by high resolution polyarylamide gel electrophoresis and sequence analyses of the PCR products of 240 primer sets. Over 100 genes with altered expression were initially identified. The expressions of 65 of these genes were further analyzed and confirmed using custom glass cDNA arrays, RT-PCR and real-time PCR. Immunomodulatory genes such as CD2, HIFI. CXCL2. L-plastin, LILR and IFI30 were affected by CT. In addition, 14 novel genes with previously unknown functions were found to be CT induced. These CT induced gene expression alterations provide more insight in the mechanisms of CT actions. The CT induced gene expressions alterations could contribute to the CT adjuvanticity. (c) 2005 Elsevier Ltd. All rights reserved. C1 Georgetown Univ, Dept Chem, Washington, DC 20057 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. RP Yang, DCH (reprint author), Georgetown Univ, Dept Chem, 37th & 6654 Reiss Sci Bldg, Washington, DC 20057 USA. EM yangdc@georgetown.edu RI Yang, David/A-7294-2009 NR 25 TC 4 Z9 5 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD MAR PY 2006 VL 43 IS 8 BP 1267 EP 1274 DI 10.1016/j.molimm.2005.07.008 PG 8 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 017XP UT WOS:000235726900020 PM 16102829 ER PT J AU Naessens, EP Allen, KS Moretti, BE AF Naessens, EP Allen, KS Moretti, BE TI Use of Pu-240 waste as a burnable absorber in light water reactors SO NUCLEAR SCIENCE AND ENGINEERING LA English DT Article ID TRANSMUTATION AB Current burnable absorbers such as boron carbide placed in the control rod guide tubes of fresh fuel assemblies create a water displacement penalty at end of cycle (EOC) that reduces the overall maximum cycle length of the reactor. Other burnable absorbers such as gadolinium-oxide mixed in the fuel do not create the water displacement penalty but create a lower centerline melt temperature for the fresh fuel and reduce the overall enrichment for the assembly. This research proposes using a transuranic (TRU) isotope with a relatively high absorption cross section such as Pu-240 to reduce excess criticality within the reactor at beginning of cycle. The added benefit of using this TRU isotope over a standard burnable absorber is that when it absorbs a neutron it no longer negatively affects the criticality of the reactor, and it will transmutate into a fissile material that will add to the overall criticality of the reactor at EOC. C1 US Mil Acad, Dept Phys, Nucl Engn Res Grp, West Point, NY 10996 USA. RP Naessens, EP (reprint author), US Mil Acad, Dept Phys, Nucl Engn Res Grp, Bartlett Hall, West Point, NY 10996 USA. EM Edward.Naessens@usma.edu NR 10 TC 1 Z9 1 U1 0 U2 0 PU AMER NUCLEAR SOCIETY PI LA GRANGE PK PA 555 N KENSINGTON AVENUE, LA GRANGE PK, IL 60526 USA SN 0029-5639 J9 NUCL SCI ENG JI Nucl. Sci. Eng. PD MAR PY 2006 VL 152 IS 3 BP 306 EP 313 PG 8 WC Nuclear Science & Technology SC Nuclear Science & Technology GA 019KD UT WOS:000235833100006 ER PT J AU Hoeldtke, NJ AF Hoeldtke, Nathan J. TI Long-term outcome of uterine artery embolization of leiomyomata SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Hoeldtke, NJ (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAR PY 2006 VL 107 IS 3 BP 741 EP 741 DI 10.1097/01.AOG.0000203430.64845.31 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 095GJ UT WOS:000241295900038 PM 16507952 ER PT J AU Reilly, MT Huang, WL Jain, F AF Reilly, Michael T. Huang, Wenli Jain, Faquir TI Photonic crystal beamsplitting laser diode SO OPTICAL ENGINEERING LA English DT Article; Proceedings Paper CT Conference on Photonics for Space Environments IX CY AUG 02-03, 2004 CL Denver, CO SP SPIE DE Y-branch; photonic crystal laser diodes; optical gain; analog-to-digital conversion ID SEMICONDUCTOR-LASERS; BENDS AB A description of a novel Y-branch photonic crystal laser diode operating at 1.55 mu m is presented. Optical gain calculations within an InGaAsP-InP multiple-quantum-well (MQW) gain medium predict a threshold current of 0.5 mA, which is lower than a typical ridge laser. The resonant structure of the beamsplitting laser is modeled using a scattering matrix approach incorporating the effects of multiple internal reflections on the cavity mode structure and mode spacing. Phase-matching conditions are derived, taking into account all the different resonant substructures. The results from the phase-matching analysis show an operating mode that reduces threshold current beyond that of a geometrically similar conventional ridge laser. This Y-branch photonic crystal laser, when cascaded as a multichannel resonant structure, produces numerous optical intensity levels that can be used in an optical analog-to-digital converter (ADC). (c) 2006 Society of Photo-Optical Instrumentation Engineers. C1 Ciencia Inc, E Hartford, CT 06108 USA. US Mil Acad, West Point, NY 10996 USA. Univ Connecticut, Dept Elect Engn, Storrs, CT 06268 USA. RP Reilly, MT (reprint author), Ciencia Inc, 111 Roberts St,Suite K, E Hartford, CT 06108 USA. EM mtreilly@ciecnia.com NR 16 TC 0 Z9 0 U1 0 U2 1 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 2006 VL 45 IS 3 AR 034203 DI 10.1117/1.2185497 PG 7 WC Optics SC Optics GA 043SL UT WOS:000237621800020 ER PT J AU Kumar, A Stephenson, LD Murray, JN AF Kumar, A Stephenson, LD Murray, JN TI Self-healing coatings for steel SO PROGRESS IN ORGANIC COATINGS LA English DT Review DE coatings; self-healing; microcapsules; corrosion inhibitors; undercutting AB The efficacy of a "self-healing" corrosion protection coating system for use on steel enclosures for outdoor equipment has been investigated using urea formaldehyde microcapsules (50-150 mu m in diameter) containing several types of film forming compounds (healants) and corrosion inhibitors mixed into commercially available coatings systems. Five different types of inhibitors/film formers were tested, and three different techniques for application of the coatings with microcapsules were evaluated. Laboratory tests showed that when the coating system was damaged by abrasion, the microcapsules released the film forming and corrosion inhibiting compounds. Steel substrates coated with these self-healing systems were scribed and laboratory tested according to ASTM D 5894. Undercutting at the scribe (ASTM D 1654) was reduced by using microcapsules containing self-healing compounds. Growth of coating damage at the scribe was arrested in self-healing coatings with all microcapsule formulations compared to control samples. The performance of some microcapsules evaluated in this study was found to be dependent on the method of application. Published by Elsevier B.V. C1 USA, Construct Engn Res Lab, ERDC, Champaign, IL 61826 USA. Murrays Et Al, Lutherville Timonium, MD 21093 USA. RP Stephenson, LD (reprint author), USA, Construct Engn Res Lab, ERDC, POB 9005, Champaign, IL 61826 USA. EM smunay@comcast.net NR 7 TC 103 Z9 107 U1 17 U2 86 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0300-9440 J9 PROG ORG COAT JI Prog. Org. Coat. PD MAR 1 PY 2006 VL 55 IS 3 BP 244 EP 253 DI 10.1016/j.porgcoat.2005.11.010 PG 10 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA 022TR UT WOS:000236079300005 ER PT J AU Xu, LL Sun, C Petrovics, G Makarem, M Furusato, B Zhang, W Sesterhenn, IA McLeod, DG Sun, L Moul, JW Srivastava, S AF Xu, LL Sun, C Petrovics, G Makarem, M Furusato, B Zhang, W Sesterhenn, IA McLeod, DG Sun, L Moul, JW Srivastava, S TI Quantitative expression profile of PSGR in prostate cancer SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE prostate-specific gene; G-protein-coupled receptor; quantitative RT-PCR; laser capture microdissection; gene expression ID PROTEIN-COUPLED RECEPTOR; LASER-CAPTURE MICRODISSECTION; AFRICAN-AMERICAN; GENE; RISK; MUTATIONS; PCGEM1; WHITE; MEN AB PSGR is a novel member of the G-protein-coupled olfactory receptor family. Our initial report showed predominant expression of the PSGR in human prostate gland and significant alterations of PSGR expression in primary prostate cancer (CaP) specimens. The aim of this study was to provide in-depth evaluations of the expression profile of PSGR in prostatic epithelial cells of CaP patients and to evaluate the association of PSGR expression characteristics with clinico-pathologic features. In total, 220 RNA specimens, from laser capture microdissected paired benign and malignant prostatic epithelial cells of 110 CaP patients, were analyzed for PSGR expression by quantitative real-time PCR. The differential expression of PSGR between the prostatic epithelial cells of malignant and benign glands was statistically significant (P < 0.0001). Comparison of PSGR expression between paired benign and tumor cells revealed prostate tumor cell-specific overexpression in 67.2% of tumor specimens (74 of 110), decreased expression in 20.9% of tumor specimens (23 of 110) and no difference of PSGR expression between tumor and normal cells in 11.8% of specimens (13 of 110). In representative cases, PSGR expression patterns were independently confirmed by in situ RNA hybridization. The PSGR overexpression associated with higher percentage of pathologic stage, pT3, and a higher level of preoperative serum PSA. CaP cells of African-American CaP patients exhibited about two-fold increase of PSGR expression in comparison to the Caucasian American CaP patients. Strikingly high-percentage CaP cells overexpress PSGR warrants further studies of PSGR expression alterations to define subsets of CaPs. C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 Jefferson St, Rockville, MD 20852 USA. EM ssrivastava@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 NR 31 TC 22 Z9 24 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD MAR PY 2006 VL 9 IS 1 BP 56 EP 61 DI 10.1038/sj.pcan.4500836 PG 6 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 031FR UT WOS:000236690300022 PM 16231015 ER PT J AU Beaman, FD Bancroft, LW Peterson, JJ Kransdorf, MJ Menke, DM DeOrio, JK AF Beaman, Francesca D. Bancroft, Laura W. Peterson, Jeffrey J. Kransdorf, Mark J. Menke, David M. DeOrio, James K. TI Imaging characteristics of bone graft materials SO RADIOGRAPHICS LA English DT Article ID ARTICULAR-CARTILAGE; THICKNESS DEFECTS; LUMBAR SPINE; FOLLOW-UP; DEGENERATION; REPAIR; KNEE AB Bone graft materials are widely used in reconstructive orthopedic procedures to promote new bone formation and bone healing, provide a substrate and scaffolding for development of bone structure, and function as a means for direct antibiotic delivery. Bone graft materials include autografts, allografts, and synthetic substitutes. An autograft ( from the patient's own bone) supplies both bone volume and osteogenic cells capable of new bone formation. The imaging appearance of an autograft depends on its type, composition, and age. Autografts often appear as osseous fragments at radiography. At computed tomography (CT), autografts appear similar to the adjacent cortical bone. At magnetic resonance (MR) imaging, however, autografts have a variable appearance as a consequence of the viable marrow inside them, a feature not present in other graft materials. An allograft ( from cadaveric bone) has an appearance similar to that of cortical bone on radiographs and CT images. An allograft in the form of bone chips or morsels does not show those features on radiographs and CT images, but instead appears as a conglomerate with medium to high opacity and attenuation within the bone defect. In the immediate postoperative period, allografts appear hypointense on both T1- and T2-weighted MR images. Hematopoietic tissue replaces the normal fatty marrow in the later phases of graft incorporation. Synthetic bone substitutes are much more variable in imaging appearance. As the use of bone allografts and synthetic substitutes increases, familiarity with postoperative imaging features is essential for differentiation between grafts and residual or recurrent disease. (C) RSNA, 2006. C1 Mayo Clin, Dept Radiol, Jacksonville, FL 32224 USA. Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USA. Mayo Clin, Dept Orthoped, Jacksonville, FL 32224 USA. Walter Reed Army Med Ctr, Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20307 USA. RP Kransdorf, MJ (reprint author), Mayo Clin, Dept Radiol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA. EM kransdorf.mark@mayo.edu NR 32 TC 20 Z9 21 U1 1 U2 3 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD MAR-APR PY 2006 VL 26 IS 2 BP 373 EP U5 DI 10.1148/rg.262055039 PG 17 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 064GX UT WOS:000239078300005 PM 16549604 ER PT J AU Brechbie, MW Milenic, DE Garmestani, K Brady, ED Abdulla, A Overstreet, T Flynn, J AF Brechbie, MW Milenic, DE Garmestani, K Brady, ED Abdulla, A Overstreet, T Flynn, J TI Modeling clinical applications or radioimmunotherapy: Targeting the HER2 antigen SO RADIOTHERAPY AND ONCOLOGY LA English DT Meeting Abstract CT 3rd International Conference on Translational Research and Pre-Clinical Strategies in Radiation Oncology CY MAR 12-15, 2006 CL Lugano, SWITZERLAND SP European Sch Oncol, European Soc Radiotherapeut Radiol & Oncol, European Org Res & Treatment Canc, Amer Med Assoc, EACCME C1 NCI, Radioimmune & Inorgan Chem Sect, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-8140 J9 RADIOTHER ONCOL JI Radiother. Oncol. PD MAR PY 2006 VL 78 SU 1 MA 67 BP S23 EP S23 DI 10.1016/S0167-8140(06)80561-X PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 043KD UT WOS:000237599000065 ER PT J AU Sigurdsson, G Yannopoulos, D McKnite, SH Sondeen, JL Benditt, DG Lurie, KG AF Sigurdsson, G Yannopoulos, D McKnite, SH Sondeen, JL Benditt, DG Lurie, KG TI Effects of an inspiratory impedance threshold device on blood pressure and short term survival in spontaneously breathing hypovolemic pigs SO RESUSCITATION LA English DT Article DE shock; hemorrhage; resuscitation; inspiratory threshold device; circulatory and respiratory physiology ID DECOMPRESSION CARDIOPULMONARY-RESUSCITATION; HOSPITAL CARDIAC-ARREST; VENTRICULAR-FIBRILLATION; FEASIBILITY; MODEL; FLOW AB Background: The inspiratory impedance threshold device (ITD) has been shown to improve hemodynamic variables and survival outcomes during cardiopulmonary resuscitation in animals and humans. We hypothesized that use of an ITD, with a resistance of -10 cm H2O, will improve hemodynamics and short-term survival rates during hypovolemic hypotension in spontaneously breathing pigs. Methods: Female farm pigs (similar to 26 kg) were intubated and anesthetized with propofol with the dose adjusted to permit spontaneous respirations. They were bled to 50% of calculated blood volume through an arterial catheter and then prospectively randomized to either treatment with an ITD or observation alone. Arterial and intratracheal pressures as well as arterial blood gases were measured. After 90 min the ITD was removed, normal saline was administered to all surviving animals, the anesthetic was discontinued, and animals were allowed to recover. Statistical analysis was performed with one-way repeated ANOVA and survival rates were calculated with Kaplan-Meier analysis. Results: Treatment with the ITD resulted in tower intratracheal inspiratory pressure in the treatment group (-11 +/- 0.4 mmHg versus -4 +/- 0.7 mmHg, respectively, P < 0.005). Mean arterial pressure after 30min of treatment with the ITD was higher in the treatment group (61.1 +/- 5.5 mmHg versus 37.4 +/- 2.1 mmHg, respectively, P < 0.005). All pigs in the control group died within 65min of the initial bleed, whereas 7/8 (87%) treated with an ITD survived for > 90min (P < 0.001). During the recovery phase, 6/8 (75%) in the ITD group survived for > 3 h and awoke without neurological deficit; one surviving animal in the ITD group never woke up. Arterial oxygenation was not compromised in the ITD group. Conclusions: Use of an ITD improved blood pressure and short-term survival rates in a spontaneously breathing porcine model of hypovolemic hypotension. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Univ Minnesota, Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. Univ Minnesota, Cardiac Arrhythmia Ctr, Minneapolis, MN USA. USA, Inst Surg Res, Mech Trauma Res Branch, Ft Sam Houston, TX 78234 USA. RP Lurie, KG (reprint author), Minneapolis Med Res Fdn Inc, 914 S 8th St,3rd Floor, Minneapolis, MN 55404 USA. EM kturie@advancedcircutatory.com FU NHLBI NIH HHS [1R43-HL-65851] NR 23 TC 20 Z9 21 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD MAR PY 2006 VL 68 IS 3 BP 399 EP 404 DI 10.1016/j.resuscitation.2005.07.015 PG 6 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 027XS UT WOS:000236450100014 PM 16455176 ER PT J AU Jumper, JM Scribbick, FW Ho, J Reed, JB AF Jumper, J. Michael Scribbick, Frank W. Ho, Janie Reed, J. Brian TI Pathologic evaluation of radial optic neurotomy in an animal model SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES LA English DT Article DE animal model; histology; optic nerve; pathology; radial optic neurotomy ID RETINAL VEIN OCCLUSION C1 W Coast Retina Med Grp, San Francisco, CA 94107 USA. Wilford Hall USAF Med Ctr, Dept Ophthalmol, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX USA. Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA. RP Jumper, JM (reprint author), W Coast Retina Med Grp, 185 Berry St,Suite 130, San Francisco, CA 94107 USA. EM JMJumper@WestCoastRetina.com NR 5 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0275-004X J9 RETINA-J RET VIT DIS JI Retin.-J. Retin. Vitr. Dis. PD MAR PY 2006 VL 26 IS 3 BP 362 EP 364 DI 10.1097/00006982-200603000-00021 PG 3 WC Ophthalmology SC Ophthalmology GA 100QW UT WOS:000241684700021 PM 16508443 ER PT J AU Kalantar-Zadeh, K Abbott, KC Kronenberg, F Anker, SD Horwich, TB Fonarow, GC AF Kalantar-Zadeh, K Abbott, KC Kronenberg, F Anker, SD Horwich, TB Fonarow, GC TI Epidemiology of dialysis patients and heart failure patients SO SEMINARS IN NEPHROLOGY LA English DT Review DE malnutrition-inflammation complex syndrome; dialysis; protein-energy malnutrition; cachexia; chronic heart failure; reverse epidemiology; homocysteine ID BODY-MASS INDEX; STAGE RENAL-DISEASE; CHRONIC-HEMODIALYSIS PATIENTS; MALNUTRITION-INFLAMMATION COMPLEX; CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN; QUALITY-OF-LIFE; PERCUTANEOUS CORONARY INTERVENTION; CARDIOVASCULAR RISK-FACTORS; PLASMA HOMOCYSTEINE LEVELS C1 Univ Calif Los Angeles, Harbor Med Ctr, David Geffen Sch Med, Torrance, CA 90509 USA. Univ Calif Los Angeles, Los Angeles Biomed Res Ctr Harbor, Div Nephrol & Hypertens, Torrance, CA USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Innsbruck Med Univ, Div Genet Epidemiol, Dept Med Genet, Innsbruck, Austria. Charite Campus Virchow Klinikum, Div Appl Cachexia Res, Berlin, Germany. Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Clin Cardiol, London, England. Univ Calif Los Angeles, Hlth Sci Ctr, Div Cardiol, Los Angeles, CA USA. RP Kalantar-Zadeh, K (reprint author), Univ Calif Los Angeles, Harbor Med Ctr, David Geffen Sch Med, Harbor Mailbox 406,1000 W Carson St, Torrance, CA 90509 USA. EM kamkal@ucla.edu RI Kronenberg, Florian/B-1736-2008; OI Kronenberg, Florian/0000-0003-2229-1120; Abbott, Kevin/0000-0003-2111-7112; Kalantar-Zadeh, Kamyar/0000-0002-8666-0725 NR 246 TC 53 Z9 54 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0270-9295 J9 SEMIN NEPHROL JI Semin. Nephrol. PD MAR PY 2006 VL 26 IS 2 BP 118 EP 133 DI 10.1016/j.semnephrol.2005.09.005 PG 16 WC Urology & Nephrology SC Urology & Nephrology GA 027XU UT WOS:000236450400006 PM 16530605 ER PT J AU Eliasson, AH Lettieri, CJ AF Eliasson, Arn H. Lettieri, Christropher J. TI Measuring nuclear factor-KB - who cares? SO SLEEP AND BREATHING LA English DT Editorial Material ID OBSTRUCTIVE SLEEP-APNEA; CARDIOVASCULAR-DISEASE C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Sleep Disorders Ctr, Washington, DC 20307 USA. RP Eliasson, AH (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM arn.eliasson@na.amedd.army.mil NR 8 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD MAR PY 2006 VL 10 IS 1 BP 4 EP 5 DI 10.1007/s11325-005-0047-5 PG 2 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 137WT UT WOS:000244324200002 PM 16421763 ER PT J AU Seehusen, DA Asplund, CA Johnson, DR Horde, KA AF Seehusen, Dean A. Asplund, Chad A. Johnson, Dawn R. Horde, Kevin A. TI Primary evaluation and management of statin therapy complications SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE cholesterol; hydroxymethylglutaryl-CoA reductase inhibitors; adverse effects; myopathy; liver function tests ID RANDOMIZED CONTROLLED-TRIAL; CONGESTIVE-HEART-FAILURE; LIPID-LOWERING DRUGS; COA-REDUCTASE INHIBITORS; COENZYME Q(10); FAMILIAL HYPERCHOLESTEROLEMIA; CLINICAL-TRIALS; PRIMARY PREVENTION; PRIMARY-CARE; SAFETY AB HMG-CoA reductase inhibitors (statins) have become one of the most commonly prescribed classes of medications in the United States. While serious adverse events are rare, less serious events are frequently seen. Published guidelines recommend initial screening labs as well as ongoing monitoring of liver enzymes during therapy. Up to 5% of patients will have some muscle complaints while taking statins. Therefore, primary care clinicians will often be faced with real or potential complications of statin therapy. There are well established risk factors for development of these complications. Being aware of a patient's risk and using the lowest effective dose minimizes the occurrence of adverse events. The great majority of these abnormalities either do not require discontinuation of therapy or require-only brief interruption of therapy. Judicious and systematic use of laboratory testing will minimize needless evaluation and premature discontinuation of statin therapy. C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30509 USA. RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30509 USA. EM dseehusen@msn.com NR 64 TC 10 Z9 10 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2006 VL 99 IS 3 BP 250 EP 256 DI 10.1097/01.smj.0000202691.52352.55 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 095NQ UT WOS:000241315000015 PM 16553099 ER PT J AU Abdi, F Qian, ZY Mosallam, A Iyer, R Wang, JJ Logan, T AF Abdi, Frank Qian, Zhongyan Mosallam, Ayman Iyer, Ramki Wang, Jian-Juei Logan, Trent TI Composite army bridges under fatigue cyclic loading SO STRUCTURE AND INFRASTRUCTURE ENGINEERING LA English DT Article DE progressive failure analysis; GENOA; composite army bridge; fatigue analysis AB Military composite bridges offer many unique advantages to the army - for example their high strength-to-weight ratio and superior corrosion and fatigue resistance properties - compared to current steel and aluminum bridges. This paper presents the results of part of a comprehensive, on-going research program sponsored by the US Army to develop innovative field repair techniques for military composite bridges. The virtual tests were performed on the composite treadway under four different loading cases: (i) maximum shear static loading case, (ii) maximum bending static loading case, (iii) fatigue progressive failure analysis for the moving load case, and (iv) fatigue progressive failure analysis for the maximum flexural loading case. Results of virtual testing and progressive failure analysis (PFA) simulation conducted on a composite army bridge (CAB) prototype demonstrated a good match with the full-scale laboratory test results conducted in an earlier study. For instance, the variation between the maximum deflections predicted by the GENOA simulation for the maximum shear and those obtained from the full-scale tests was only 3.2%. In addition, the location and type of damages at the ultimate load were very close to those obtained from the full-scale laboratory tests. C1 Alpha Star Corp, Long Beach, CA USA. Univ Calif Irvine, Irvine, CA 92717 USA. USA, TARDEC, Warren, MI USA. Boeing Co, Huntington Beach, CA USA. RP Abdi, F (reprint author), Alpha Star Corp, Long Beach, CA USA. EM fabdi@alphastarcorp.com NR 11 TC 3 Z9 3 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1573-2479 J9 STRUCT INFRASTRUCT E JI Struct. Infrastruct. Eng. PD MAR PY 2006 VL 2 IS 1 BP 63 EP 73 DI 10.1080/15732470500254691 PG 11 WC Engineering, Civil; Engineering, Mechanical SC Engineering GA 113TV UT WOS:000242621300008 ER PT J AU Mittendorf, EA Gurney, JM Storrer, CE Shriver, CD Ponniah, S Peoples, GE AF Mittendorf, EA Gurney, JM Storrer, CE Shriver, CD Ponniah, S Peoples, GE TI Vaccination with a HER2/neu peptide induces intra- and inter-antigenic epitope spreading in patients with early stage breast cancer SO SURGERY LA English DT Article ID CIRCULATING TUMOR-CELLS; CYTOTOXIC T-LYMPHOCYTES; FOLATE BINDING-PROTEIN; DENDRITIC CELLS; OVARIAN-CANCER; IN-VIVO; HER-2/NEU; INDUCTION; RESPONSES; IMMUNIZATION AB Background. We are conducting clinical vaccine trials with the HER2/neu peptide, E75, in patients with breast cancer. The purpose of this study was to demonstrate clonal expansion of E75-specific CD8(+) T cells and to identify intra- and interantigenic epitope spreading. Method. Pre- and postvaccination peripheral blood leukocyte samples (24 node positive [NP] and 20 node negative [NN]) from 44 vaccinated patients were analyzed. HLA-A2:Ig dimer molecules were loaded with the HER2 peptides, E75 or GP2, and were used with anti-TcR and CD8 antibodies to stain peripheral blood leukocyte immediately ex vivo and were analyzed with flow cytometry. In 8 randomly selected patients, dimers were loaded with the folate binding protein peptide E41 to evaluate for interantigenic epitope spreading. Results. All patients with NP and 95% of the patients with NN showed E75-specific clonal expansion. Patients with NN showed more robust expansion. All patients with NP and 85% of the patients with NN showed evidence of intra-antigenic epitope that was spreading to GP2. However patients with NN showed only moderate expansion to this subdominant epitope, which was not included in the immunizing mix. The degree of HER2/neu expression and disease stage impacted the ability to expand clonally E75- and GP2-specific CD8(+) T cells. Evidence of interantigenic epitope spreading to E41 was shown in 63% of the patients who were tested. Conclusion. Our data provide evidence for the induction of intra- anti interantigenic epitope spreading that results from a single HER2/neu peptide vaccine even in early staged patients. The ability to raise immunity to multiple tumor antigens depends on both the degree of HER2/neu expression and the extent of disease. Epitope spreading is an essential element for the success of a peptide vaccine strategy. C1 Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Immunol & Res Ctr, Clin Breast Care Project, Bethesda, MD USA. RP Peoples, GE (reprint author), Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.peoples@na.amedd.army.mil NR 26 TC 25 Z9 25 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0039-6060 J9 SURGERY JI Surgery PD MAR PY 2006 VL 139 IS 3 BP 407 EP 418 DI 10.1016/j.surg.2005.06.059 PG 12 WC Surgery SC Surgery GA 028MB UT WOS:000236490500018 PM 16546506 ER PT J AU Cho, MS Battista, V Dubin, NH Pirela-Cruz, M AF Cho, MS Battista, V Dubin, NH Pirela-Cruz, M TI Assessment of four midcarpal radiologic determinations SO SURGICAL AND RADIOLOGIC ANATOMY LA English DT Article DE interobserver reliability; intraobserver reproducibility; midcarpal alignment static radiographic measurements; triangulation method ID WRIST; RELIABILITY; TRIANGULATION; GONIOMETRY; KINEMATICS; MOTION; JOINT AB Several radiologic measurement methods have been described for determining static carpal alignment of the wrist. These include the scapholunate, radiolunate, and capitolunate angles. The triangulation method is an alternative radiologic measurement which we believe is easier to use and more reproducible and reliable than the above mentioned methods. The purpose of this study is to assess the intraobserver reproducibility and interobserver reliability of the triangulation method, scapholunate, radiolunate, and capitolunate angles. Twenty orthopaedic residents and staff at varying levels of training made four radiologic measurements including the scapholunate, radiolunate and capitolunate angles as well as the triangulation method on five different lateral, digitized radiographs of the wrist and forearm in neutral radioulnar deviation. Thirty days after the initial measurements, the participants repeated the four radiologic measurements using the same radiographs. The triangulation method had the best intra-and-interobserver agreement of the four methods tested. This agreement was significantly better than the capitolunate and radiolunate angles. The scapholunate angle had the next best intraobserver reproducibility and interobserver reliability. The triangulation method has the best overall observer agreement when compared to the scapholunate, radiolunate, and capitolunate angles in determining static midcarpal alignment. No comment can be made on the validity of the measurements since there is no radiographic gold standard in determining static carpal alignment. C1 Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed Surg, El Paso, TX 79905 USA. USA, Med Corps, William Beaumont Army Med Ctr, El Paso, TX USA. USA, Med Corps, Walter Reed Army Med Ctr, Washington, DC 20310 USA. Union Mem Hosp, Lab Serv, Baltimore, MD USA. RP Pirela-Cruz, M (reprint author), Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed Surg, 4800 Alberta Ave, El Paso, TX 79905 USA. EM cruzer@zianet.com NR 16 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1279-8517 J9 SURG RADIOL ANAT JI Surg. Radiol. Anat. PD MAR PY 2006 VL 28 IS 1 BP 92 EP 97 DI 10.1007/s00276-005-0038-z PG 6 WC Anatomy & Morphology; Radiology, Nuclear Medicine & Medical Imaging; Surgery SC Anatomy & Morphology; Radiology, Nuclear Medicine & Medical Imaging; Surgery GA 016SF UT WOS:000235639700016 PM 16341825 ER PT J AU Kavic, SM Segan, RD George, IM Turner, PL Roth, JS Park, A AF Kavic, Stephen M. Segan, Ross D. George, Ivan M. Turner, Patricia L. Roth, J. Scott Park, Adrian TI Classification of a hiatal hernias using dynamic three-dimensional reconstruction SO SURGICAL INNOVATION LA English DT Article DE hiatal hernia; paraesophageal hernia; classification; computed tomography (CT) AB Hiatal hernias and paraesophageal hernias are common clinical entities and have a well-known classification system. Multiple modalities have been used to illustrate these hernias, most relying on artists' renderings or two-dimensional radiographic studies. However, surgeons would benefit from a comprehensive graphic representation of hiatal hernias based on current imaging technologies. We have applied polygonal mesh surface modeling techniques to render dynamic three-dimensional computed tomography-based models of the four recognized types of hiatal hernias. The resulting images allow nearly real-time navigation in an intuitive and clinically relevant fashion. This model should clarity and eventually advance the existing classification by applying modern and sophisticated image processing to established concepts. C1 Univ Maryland, Div Gen Surg, Baltimore, MD 21201 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Park, A (reprint author), Univ Maryland, Div Gen Surg, Rm S4B14,22 S Greene St, Baltimore, MD 21201 USA. EM apark@smail.umaryland.edu NR 13 TC 3 Z9 4 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1553-3506 J9 SURG INNOV JI Surg. Innov. PD MAR PY 2006 VL 13 IS 1 BP 49 EP 52 DI 10.1177/155335060601300108 PG 4 WC Surgery SC Surgery GA 148ZH UT WOS:000245115400008 PM 16708155 ER PT J AU McLeod, IK Arciero, C Noordzij, JP Stojadinovic, A Peoples, G Melder, PC Langley, R Bernet, V Shriver, CD AF McLeod, IK Arciero, C Noordzij, JP Stojadinovic, A Peoples, G Melder, PC Langley, R Bernet, V Shriver, CD TI The use of rapid parathyroid hormone assay in predicting postoperative hypocalcemia after total or completion thyroidectomy SO THYROID LA English DT Article ID CALCIUM LEVELS; SURGERY; AUTOTRANSPLANTATION; SAFETY; GLAND AB Purpose: To evaluate the rapid parathyroid hormone assay (rPTH) as a perioperative tool in predicting postoperative symptomatic hypocalcemia following thyroidectomy. Methods: We conducted a prospective study of 69 patients undergoing total or completion thyroidectomy. Rapid PTH levels were obtained preoperatively, intraoperatively, and postoperatively upon arrival in the postanesthesia care unit (PACU). All patients were closely monitored postoperatively for the development of symptomatic or asymptomatic hypocalcemia. Results: Of 60 patients (25%) undergoing thyroidectomy, 15 developed hyypocalcemia, 7 (11.7%) were symptomatic, and 8 (13.3%) asymptomatic. An intraoperative rPTH level less than 12 pg/mL was 71% sensitive and 95% specific for predicting postoperative symptomatic hypocalcemia, whereas a PACU rPTH. level less than 12 pg/mL was 100%, sensitive and 92%, specific. A greater than 75%, decline in preoperative rPTH level when measured intraoperatively was 71% sensitive and 86% specific, whereas a greater than 75% decline in rPTH level in the PACU was 100% sensitive and 88% specific for predicting symptomatic hypocalcemia. Conclusions: The rPTH. assay is a highly accurate and effective tool for predicting symptomatic hypocalcemia immediately after thyroidectomy. Routine utilization of this assay is recommended, because it will allow safe and timely discharge of normocalcemic patients and the early identification of patients requiring treatment of postthyroidectomy hypocalcemia. C1 Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Gen Surg, Washington, DC USA. Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC USA. RP McLeod, IK (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 24 TC 41 Z9 42 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 J9 THYROID JI Thyroid PD MAR PY 2006 VL 16 IS 3 BP 259 EP 265 DI 10.1089/thy.2006.16.259 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 029CB UT WOS:000236534500010 PM 16571088 ER PT J AU Cardo, LJ Asher, L AF Cardo, LJ Asher, L TI Electron micrographic study of the removal of Leishmania from blood products by leukodepletion filters SO TRANSFUSION LA English DT Editorial Material C1 Walter Reed Army Inst Res, Transfus Med Branch, Dept Blood Res, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. RP Cardo, LJ (reprint author), Walter Reed Army Inst Res, Transfus Med Branch, Dept Blood Res, Silver Spring, MD 20910 USA. EM Lisa.Cardo@us.army.mil NR 0 TC 4 Z9 4 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAR PY 2006 VL 46 IS 3 BP 315 EP 316 DI 10.1111/j.1537-2995.2006.00725.x PG 2 WC Hematology SC Hematology GA 016ZA UT WOS:000235662500001 PM 16533268 ER PT J AU Duffy, PE Fried, M AF Duffy, PE Fried, M TI Red blood cells that do and red blood cells that don't: how to resist a persistent parasite SO TRENDS IN PARASITOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM; SEVERE MALARIA; HEMOGLOBIN-C; G6PD DEFICIENCY; PROTECTION; ERYTHROCYTES; CHILDREN; TRAIT; PHAGOCYTOSIS; MECHANISM AB Sixty years ago, Haldane proposed that certain abnormalities in red blood cells could be selected as malaria-resistance genes. Population studies have confirmed that many human polymorphisms confer resistance to severe malaria, although the mechanisms of protection remain unknown. A recent article proposes a new mechanism for explaining the protective effects of hemoglobin C (HbC). HbC-containing red blood cells have modified displays of malaria surface proteins that reduce parasite adhesiveness and could reduce the risk of severe disease. C1 Seattle Biomed Res Inst, Seattle, WA 98109 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, 307 Westlake Ave N,Suite 500, Seattle, WA 98109 USA. EM patrick.duffy@sbri.org NR 17 TC 3 Z9 4 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD MAR PY 2006 VL 22 IS 3 BP 99 EP 101 DI 10.1016/j.pt.2006.01.009 PG 3 WC Parasitology SC Parasitology GA 028JS UT WOS:000236484100002 PM 16455302 ER PT J AU Armstrong, PJ Franklin, DP AF Armstrong, Peter J. Franklin, David P. TI Superior mesenteric artery branch aneurysm with absence of the celiac trunk SO VASCULAR LA English DT Article DE aneurysm; celiac artery agenesis; pancreaticoduodenal artery; superior mesenteric artery AB Superior mesenteric artery and pancreaticoduodenal artery aneurysms are rare. Agenesis of the celiac axis has only been reported four times. The reported etiologies of superior mesenteric artery and branch artery aneurysms include infection, atherosclerosis, inflammatory processes such as pancreatitis, dissection, collagen vascular disorders, polyarteritis nodosa, and trauma. We report an aneurysm of the superior mesenteric artery (SMA) branch, the inferior pancreaticoduodenal artery, arising in a patient with congenital absence of the celiac trunk. The patient presented with intermittent left upper quadrant pain without weight loss or change in bowel habits. The aneurysm was identified on abdominal computed tomography scan with angiographic confirmation of the aberrant anatomy. The patient was treated by aneurysmectomy and pancreaticoduodenal artery reconstruction with an interposition vein graft from the SMA. The patient recovered without complications and is asymptomatic with a patent vein graft 2 years after operation. C1 Eisenhower Army Med Ctr, Vasc Surg Sect, Ft Gordon, GA USA. Geisinger Med Ctr, Vasc Surg Sect, Danville, PA 17822 USA. RP Armstrong, PJ (reprint author), Eisenhower Army Med Ctr, Vasc Surg Sect, Ft Gordon, GA USA. EM peter.armstrong@se.amedd.army.mil NR 21 TC 4 Z9 4 U1 0 U2 1 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1708-5381 J9 VASCULAR JI Vascular PD MAR-APR PY 2006 VL 14 IS 2 BP 109 EP 112 DI 10.2310/6670.2006.00015 PG 4 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA V44FV UT WOS:000202989500008 PM 16956480 ER PT J AU Schierholz, EL Gulliver, JS Wilhelms, SC Henneman, HE AF Schierholz, EL Gulliver, JS Wilhelms, SC Henneman, HE TI Gas transfer from air diffusers SO WATER RESEARCH LA English DT Article DE surface transfer; bubble transfer; liquid film coefficient; aeration; diffuser; sparger ID OXYGEN MASS-TRANSFER; BUBBLE-COLUMNS; AERATION SYSTEMS; HOLDUP AB The bubble and surface volumetric mass transfer coefficients for oxygen, k(L)a(b) and k(L)a(s), are separately deter-mined for 179 aeration tests, with diffuser depths ranging from 2.25 to 32 m, using the DeMoyer et al. [2003. impact of bubble and free surface oxygen transfer on diffused aeration systems. Water Res 37, 1890-1904] mass transfer model. Two empirical characterization equations are developed for k(L)a(b) and k(L)a(s), correlating the coefficients to air flow, Q(a), diffuser depth, h(d), cross-sectional area, A(CS), and volume, V. The characterization equations indicate that the bubble transfer coefficient, k(L)a(b), increases with increasing gas flow rate and depth, and decreases with increasing water volume. For fine bubble diffusers, k(L)a(b) is approximately six times greater than kLab for coarse bubble diffusers. The surface transfer coefficient, k(L)A(s), increases with increasing gas flow rate and diffuser depth. The characterization equations make it possible to predict the gas transfer that will occur across bubble interfaces and across the free surface with a bubble plume at depths up to 32 m and with variable air discharge in deep tanks and reservoirs. (c) 2006 Elsevier Ltd. All rights reserved. C1 Univ Minnesota, Dept Civil Engn, St Anthony Falls Lab, Minneapolis, MN 55414 USA. Brown & Caldwell, St Paul, MN 55101 USA. USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. USA, Corps Engineers, Chicago, IL 60606 USA. RP Gulliver, JS (reprint author), Univ Minnesota, Dept Civil Engn, St Anthony Falls Lab, Mississippi River 3rd Ave SE, Minneapolis, MN 55414 USA. EM gulli003@tc.umn.edu NR 20 TC 16 Z9 19 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD MAR PY 2006 VL 40 IS 5 BP 1018 EP 1026 DI 10.1016/j.watres.2005.12.033 PG 9 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 025XH UT WOS:000236300100019 PM 16490229 ER PT J AU Stetz, TA Stetz, MC Bliese, PD AF Stetz, TA Stetz, MC Bliese, PD TI The importance of self-efficacy in the moderating effects of social support on stressor-strain relationships SO WORK AND STRESS LA English DT Article DE social support; self-efficacy; organizational constraints; work-related stress; stressor-strain relationships ID OCCUPATIONAL STRESS; COLLECTIVE-EFFICACY; BELIEFS; IMPACT; MULTILEVEL; LEADERSHIP; TALKING AB Occupational stress research offers inconsistent findings on the moderating effects of social support on the stressor-strain relationship. This study contributes to the research literature by examining how social support's moderating effect is dependent on one's self-efficacy. Ninety-six US military police soldiers completed two surveys 3 months apart. The results showed that three out of four regression equations had significant three-way interactions. Organizational constraints x supervisor support x self-efficacy had statistically significant interactions in the prediction of job satisfaction and psychological well-being. Organizational constraints x co-worker support x self-efficacy had a significant interaction in the predicted of psychological well-being. These interactions explained between 5% and 10% of the variance in the dependent variables. Social support buffered the stressor-strain relationship when self-efficacy was high and reverse buffered the relationship when self-efficacy was low. These results indicate that interventions aimed at reducing strains by increasing social support should consider an individual's self-efficacy. Future research should consider incorporating content of communication to determine if high and low self-efficacy individuals receive or react differently to different types of communication content. C1 Natl Geospatial Intelligence Agcy, Bethesda, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Stetz, TA (reprint author), 26 Irwin St, Ft Rucker, AL 36362 USA. EM tastetz@Yahoo.com NR 33 TC 33 Z9 37 U1 4 U2 20 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0267-8373 J9 WORK STRESS JI Work Stress PD MAR PY 2006 VL 20 IS 1 BP 49 EP 59 DI 10.1080/02678370600624039 PG 11 WC Psychology, Applied SC Psychology GA 055VU UT WOS:000238479600005 ER PT J AU Marshall, DA Walizer, EM Vernalis, MN AF Marshall, DA Walizer, EM Vernalis, MN TI Enhancing achievement of healthy lifestyle habits in military healthcare beneficiaries through a lifestyle intervention program SO CIRCULATION LA English DT Meeting Abstract CT 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention CY MAR 02-05, 2006 CL Phoenix, AZ SP Amer Heart Assoc, Natl Heart, Lung & Blood Inst C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Henry M Jackson Fdn, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD FEB 28 PY 2006 VL 113 IS 8 MA P88 BP E329 EP E329 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 016KW UT WOS:000235620100149 ER PT J AU Oh, SY Chiu, PC Kim, BJ Cha, DK AF Oh, SY Chiu, PC Kim, BJ Cha, DK TI Enhanced reduction of perchlorate by elemental iron at elevated temperatures SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE perchlorate; reduction; elemental iron; temperature ID DRINKING-WATER; IONS; ACID AB Kinetics of perchlorate reduction by elemental iron was examined at elevated temperatures using microwave heating and conventional block heating. It was hypothesized that increasing the solution temperature may accelerate the reduction of perchlorate by overcoming the high activation energy barrier. Results from microwave heating study showed that 98% of aqueous perchlorate was removed in 1 h at 200 degrees C. Similar results observed in control experiments with a block heater indicated that the enhancement in the extent and rate of perchlorate removal by elemental iron was mostly due to heat energy at high temperature. The rapid and complete reduction of perchlorate by elemental iron at elevated temperatures suggests that iron reduction process at elevated temperature may be an option to consider for complete removal of perchlorate from industrial discharges. Crown Copyright (c) 2005 Published by Elsevier B.V. All rights reserved. C1 Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. US Army Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Cha, DK (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM cha@ce.udel.edu NR 17 TC 31 Z9 36 U1 2 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 28 PY 2006 VL 129 IS 1-3 BP 304 EP 307 DI 10.1016/j.jhazmat.2005.09.006 PG 4 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 025WY UT WOS:000236299100040 PM 16243433 ER PT J AU DeZee, KJ Shimeall, WT Douglas, KM Shumway, NM O'Malley, PG AF DeZee, KJ Shimeall, WT Douglas, KM Shumway, NM O'Malley, PG TI Treatment of excessive anticoagulation with phytonadione (vitamin K) - A meta-analysis SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article; Proceedings Paper CT 27th Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 12-15, 2004 CL Chicago, IL SP Soc Gen Internal Med ID INTERNATIONAL NORMALIZED RATIO; WARFARIN-ASSOCIATED COAGULOPATHY; RANDOMIZED CONTROLLED-TRIAL; SUBCUTANEOUS PHYTONADIONE; OVER-WARFARINIZATION; ORAL ANTICOAGULATION; REVERSAL; THERAPY; HYPOPROTHROMBINEMIA; DISCONTINUATION AB Background: : Patients taking oral anticoagulants with an international normalized ratio (INR) greater than 4.0 are at increased risk for bleeding. We performed a meta-analysis to determine the effectiveness of phytonadione ( vitamin K) in treating excessive anticoagulation. Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched ( without language restrictions) for articles published between January 1985 and September 2004. Randomized controlled trials or prospective, nonrandomized trials that used vitamin K to treat patients without major hemorrhage with an INR greater than 4.0 due to oral anticoagulant use were included. The primary outcome was achievement of the target INR (1.8-4.0) at 24 hours after vitamin K administration. Summary estimates were calculated using a random effects model. Results: Twenty-one studies ( 10 randomized and 11 prospective trials) were included. Among oral vitamin K treatment arms ( 4, n = 75), the proportion with a target INR at 24 hours was 82% (95% confidence interval [CI], 70%-93%), which was similar to intravenous vitamin K treatment arms ( 6, n= 69; target INR, 77%; 95% CI, 60%-95%). Treatment arms of subcutaneous vitamin K ( 3, n= 58; 31%; 95% CI, 7%-55%) and placebo/observation ( 2, n= 27; 20%; 95% CI, 0%- 47%) were less likely to achieve target INR at 24 hours. Only 1 of 21 trials appropriately assessed for adverse events, so a summary estimate for bleeding risk could not be generated. Conclusions: Limited evidence suggests that oral and intravenous vitamin K are equivalent and more effective for excessive anticoagulation than simply withholding warfarin sodium. Subcutaneous vitamin K, however, is inferior to oral and intravenous vitamin K for this indication and is similar to placebo. Whether treatment with vitamin K decreases hemorrhagic events cannot be determined from the published literature. C1 William Beaumont Army Med Ctr, Dept Med, El Paso, TX 79920 USA. Natl Naval Med Res Inst, Bethesda, MD USA. Brooke Army Med Ctr, San Antonio, TX USA. RP DeZee, KJ (reprint author), William Beaumont Army Med Ctr, Dept Med, 5005 N Piedras St, El Paso, TX 79920 USA. EM kent.dezee@us.army.mil NR 38 TC 12 Z9 14 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD FEB 27 PY 2006 VL 166 IS 4 BP 391 EP 397 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 017YW UT WOS:000235730400002 PM 16505257 ER PT J AU Byrd, W Cassels, FJ AF Byrd, W Cassels, FJ TI Intranasal immunization of BALB/c mice with enterotoxigenic Escherichia coli colonization factor CS6 encapsulated in biodegradable poly(DL-lactide-co-glycolide) microspheres SO VACCINE LA English DT Article DE enterotoxigenic Escherichia coli (ETEC); colonization factor (CS6); intranasal; microspheres ID HEAT-LABILE ENTEROTOXIN; DELIVERY SYSTEMS; RESPIRATORY-TRACT; MUCOSAL; VACCINE; ADJUVANT; ANTIGEN; TOXIN; RESPONSES; CHOLERA AB Mice were intranasally administered enterotoxigenic Escherichia coli colonization factor CS6 encapsulated in poly((DL)-lactide-co-glycolide) microspheres (CS6-PLG), with immune response measured and compared to that of similarly administered native CS6 and CS6 plus mutant heat-labile enterotoxin mucosal adjuvant (CS6 + mLT). Native CS6 and the CS6-PLG microspheres administered intranasally to mice induced serum IgG responses, with the CS6-PLG microspheres inducing a significantly greater (P < 0.001) response than native CS6. Following intranasal administration of native CS6, no fecal IgG and IgA responses were measured; however, the CS6-PLG microspheres induced significantly greater (P < 0.001) fecal IgG and IgA responses than native CS6. The coadministration of the mLT mucosal adjuvant with CS6 induced significantly greater serum (P < 0.001)and fecal (P < 0.01) responses than the CS6-PLG microspheres. However,following intranasal administration of the mLT adjuvant, the mice showed definite signs of distress, indicating an adverse reaction to the mLT. Thus, this brings into question the safety of the mLT and its use as an intranasal adjuvant. In contrast, the PI-G-microspheres administered intranasally caused no noticeable distress to the mice. The results obtained in this study indicate that the encapsulation of CS6 in PLG-microspheres administered intranasally to mice acted in an adjuvant capacity to enhance the CS6 immune response. Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD 20919 USA. RP Byrd, W (reprint author), 20144 Timber Oak Lane, Germantown, MD 20874 USA. EM dagmarbyrd@comcast.net NR 40 TC 14 Z9 14 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB 27 PY 2006 VL 24 IS 9 BP 1359 EP 1366 DI 10.1016/j.vaccine.2005.09.024 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 019VG UT WOS:000235864200017 PM 16233937 ER PT J AU Amemiya, K Meyers, JL Trevino, SR Chanh, TC Norris, SL Waag, DM AF Amemiya, K Meyers, JL Trevino, SR Chanh, TC Norris, SL Waag, DM TI Interleukin-12 induces a Th1-like response to Burkholderia mallei and limited protection in BALB/c mice SO VACCINE LA English DT Article DE IL-12; Th1 response; limited protection ID VACCINE-INDUCED IMMUNITY; IFN-GAMMA PRODUCTION; SCHISTOSOMA-MANSONI; LEISHMANIA-MAJOR; T-CELLS; IL-12; RESISTANCE; INFECTION; ADJUVANT; INDUCTION AB We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-gamma production by splenocytes from mice that received B. mallei and IL-12. We saw an increase in survivors in the groups of mice that received B. mallei and IL-12 when challenged, compared to mice that received only B. mallei or IL-12. The results Suggest that IL-12 can enhance the Th1-like immune response to B. mallei and mediate limited protection from a lethal challenge. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Amemiya, K (reprint author), USA, Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM kei.amemiya@det.amedd.army.mil NR 40 TC 19 Z9 21 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB 27 PY 2006 VL 24 IS 9 BP 1413 EP 1420 DI 10.1016/j.vaccine.2005.09.021 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 019VG UT WOS:000235864200024 PM 16213631 ER PT J AU Riddle, MS Smoak, BL Thornton, SA Bresee, JS Faix, DJ Putnam, SD AF Riddle, MS Smoak, BL Thornton, SA Bresee, JS Faix, DJ Putnam, SD TI Epidemic infectious gastrointestinal illness aboard US Navy ships deployed to the Middle East during peacetime operations - 2000-2001 SO BMC GASTROENTEROLOGY LA English DT Article ID NORWALK-LIKE-VIRUS; CRUISE SHIPS; ACUTE GASTROENTERITIS; UNITED-STATES; VIRAL GASTROENTERITIS; DIARRHEAL DISEASE; NOROVIRUS; OUTBREAKS; TRANSMISSION AB Background: Infectious gastrointestinal illness (IGI) outbreaks have been reported in U. S. Navy ships and could potentially have an adverse mission impact. Studies to date have been anecdotal. Methods: We conducted a retrospective analysis of weekly reported disease and non-battle injury health data collected in 2000 - 2001 from 44 U. S. Navy ships while sailing in the 5th Fleet ( Persian Gulf and nearby seas). Results: During this period, 11 possible IGI outbreaks were identified. Overall, we found 3.3 outbreaks per 100 ship-weeks, a mean outbreak duration of 4.4 weeks, and a mean cumulative ship population attack rate of 3.6%. Morbidity, represented by days lost due to personnel being placed on sick-in-quarters status, was higher during outbreak weeks compared to non-outbreak weeks ( p = 0.002). No clear seasonal distribution was identified. Conclusion: Explosive outbreaks due to viruses and bacteria with the potential of incapacitating large proportions of the crew raise serious concerns of mission impact and military readiness. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. Navy Environm & Prevent Med Unit 6, Honolulu, HI USA. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Atlanta, GA USA. Navy Environm & Prevent Med Unit 5, San Diego, CA USA. USN, Med Res Unit 2, Jakarta, Indonesia. RP Riddle, MS (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. EM mriddle@usuhs.mil; bonnie.smoak@us.army.mil; thornton@nepmu6.med.navy.mil; jsb6@cdc.gov; dfaix@med.navy.mil; shan8299@hotmail.com RI Riddle, Mark/A-8029-2011; Valle, Ruben/A-7512-2013 NR 29 TC 7 Z9 7 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-230X J9 BMC GASTROENTEROL JI BMC Gastroenterol. PD FEB 25 PY 2006 VL 6 AR 9 DI 10.1186/1471-230X-6-9 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 038YI UT WOS:000237265200001 PM 16504135 ER PT J AU Joyce, J Cook, J Chabot, D Hepler, R Shoop, W Xu, QW Stambaugh, T Aste-Amezaga, M Wang, S Indrawati, L Bruner, M Friedlander, A Keller, P Caulfield, M AF Joyce, J Cook, J Chabot, D Hepler, R Shoop, W Xu, QW Stambaugh, T Aste-Amezaga, M Wang, S Indrawati, L Bruner, M Friedlander, A Keller, P Caulfield, M TI Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategy SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID NEISSERIA-MENINGITIDIS; POLY(GAMMA-D-GLUTAMIC ACID); STAPHYLOCOCCUS-AUREUS; VACCINE; MEMBRANE; POLYSACCHARIDE; SAFETY; PEPTIDE; CARBODIIMIDE; IMMUNIZATION AB The capsular polypeptide of Bacillus anthracis is composed of a unique polyglutamic acid polymer in which D-glutamate monomers are joined by gamma-peptidyl bonds. The capsule is poorly immunogenic, and efforts at exploiting the polymer for vaccine development have focused on increasing its inherent immunogenicity through chemical coupling to immune-stimulating protein carriers. The usual strategy has employed carbodiimide-based condensing reagents for activation of free alpha-carboxyl groups, despite reports that this chemistry may lead to chain scission. We have purified the high molecular mass capsule to > 95% homogeneity and have demonstrated that the polymer contains > 99% poly-gamma-D-glutamic acid. The predominant structure of the polymer as assessed by circular dichroism and multiangle laser light scattering was unordered at near-neutral pH. We investigated the effects of various activation chemistries, and we demonstrated that carbodiimide treatment under aqueous conditions results in significant cleavage of the alpha-peptidyl bond, whereas scission is significantly reduced in nonaqueous polar solvents, although undesired side chain modification was still observed. An activation chemistry was developed using the triazine-based reagent 4-(4,6-dimethoxy (1,3,5) triazin-2-yl)-4-methylmorpholinium chloride, which allowed for controlled and reproducible derivatization of alpha-carbonyls. In a two-pot reaction scheme, activated capsule was derivatized with a sulfhydryl-reactive heterobifunctional moiety and was subsequently coupled to thiolated carrier protein. This conjugate elicited very high capsule-specific immune titers in mice. More importantly, mice immunized with conjugated capsule exhibited good protection against lethal challenge from a virulent B. anthracis strain in two models of infection. We also showed, for the first time, that treatment of capsule with carbodiimide significantly reduced recognition by capsule-specific antisera concurrent with the reagent-induced reduction of polymer mass. The data suggested that for vaccine development, maintenance of the high mass of the polymer may be important. C1 Merck Res Labs, Dept Vaccine Res, Lab Sci & Investigat Toxicol & Bioproc & Bioanaly, West Point, PA 19486 USA. Merck Res Labs, Dept Biol Res, Lab Sci & Investigat Toxicol & Bioproc & Bioanaly, West Point, PA 19486 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21701 USA. Merck Res Labs, Dept Human & Anim Infect Dis Res, Rahway, NJ 07065 USA. Lockheed Martin, Edison, NJ 08837 USA. RP Joyce, J (reprint author), Merck Res Labs, Dept Vaccine & Biol Res, POB 4, West Point, PA 19486 USA. EM joseph_joyce@merck.com RI Hepler, Robert/A-9664-2008 OI Hepler, Robert/0000-0003-4344-8203 NR 52 TC 49 Z9 51 U1 1 U2 10 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD FEB 24 PY 2006 VL 281 IS 8 BP 4831 EP 4843 DI 10.1074/jbc.M509432200 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 013RF UT WOS:000235426200034 PM 16293624 ER PT J AU Ratushna, VG Sturgill, DM Ramamoorthy, S Reichow, SA He, YQ Lathigra, R Sriranganathan, N Halling, SM Boyle, SM Gibas, CJ AF Ratushna, VG Sturgill, DM Ramamoorthy, S Reichow, SA He, YQ Lathigra, R Sriranganathan, N Halling, SM Boyle, SM Gibas, CJ TI Molecular targets for rapid identification of Brucella spp SO BMC MICROBIOLOGY LA English DT Article ID NEAREST-NEIGHBOR THERMODYNAMICS; INTRACELLULAR TRAFFICKING; GENOME SEQUENCE; GLOBAL ANALYSIS; GENUS BRUCELLA; IV SECRETION; INCP PLASMID; MELITENSIS; ABORTUS; GENES AB Background: Brucella is an intracellular pathogen capable of infecting animals and humans. There are six recognized species of Brucella that differ in their host preference. The genomes of the three Brucella species have been recently sequenced. Comparison of the three revealed over 98% sequence similarity at the protein level and enabled computational identification of common and differentiating genes. We validated these computational predictions and examined the expression patterns of the putative unique and differentiating genes, using genomic and reverse transcription PCR. We then screened a set of differentiating genes against classical Brucella biovars and showed the applicability of these regions in the design of diagnostic tests. Results: We have identified and tested set of molecular targets that are associated in unique patterns with each of the sequenced Brucella spp. A comprehensive comparison was made among the published genome sequences of B. abortus, B. melitensis and B. suis. The comparison confirmed published differences between the three Brucella genomes, and identified subsets of features that were predicted to be of interest in a functional comparison of B. melitensis and B. suis to B. abortus. Differentiating sequence regions from B. abortus, B. melitensis and B. suis were used to develop PCR primers to test for the existence and in vitro transcription of these genes in these species. Only B. suis is found to have a significant number of unique genes, but combinations of genes and regions that exist in only two out of three genomes and are therefore useful for diagnostics were identified and confirmed. Conclusion: Although not all of the differentiating genes identified were transcribed under steady state conditions, a group of genes sufficient to discriminate unambiguously between B. suis, B. melitensis, and B. abortus was identified. We present an overview of these genomic differences and the use of these features to discriminate among a number of Brucella biovars. C1 Univ N Carolina, Dept Comp Sci, Coll Informat Technol, Charlotte, NC 28223 USA. Virginia Polytech Inst & State Univ, Coll Sci, Dept Biol, Blacksburg, VA 24061 USA. Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. Univ Michigan, Sch Med, Unit Lab Anim Med, Ann Arbor, MI 48105 USA. Walter Reed Army Inst Res, Dept Bacterial Dis, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. ARS, Bacterial Dis Livestock Res Unit, USDA, Natl Anim Dis Ctr, Ames, IA 50010 USA. RP Gibas, CJ (reprint author), Univ N Carolina, Dept Comp Sci, Coll Informat Technol, Charlotte, NC 28223 USA. EM vgratush@uncc.edu; davidsturgill@niddk.nih.gov; sheelar@vt.edu; Sherry.Reichow@hsi.dhs.gov; yongqunh@umich.edu; Raju.Lathigra@na.amedd.army.mil; nathans@vt.edu; shalling@nadc.ars.usda.gov; smboyle@vt.edu; cgibas@uncc.edu OI Gibas, Cynthia/0000-0002-1288-9543; He, Yongqun/0000-0001-9189-9661 NR 54 TC 26 Z9 31 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD FEB 22 PY 2006 VL 6 AR 13 DI 10.1186/1471-2180-6-13 PG 20 WC Microbiology SC Microbiology GA 025NM UT WOS:000236273100001 PM 16504063 ER PT J AU Taylor, AJ Bindeman, J Feuerstein, IM Byrd, C Le, TP Bauer, K O'Malley, PG AF Taylor, AJ Bindeman, J Feuerstein, IM Byrd, C Le, TP Bauer, K O'Malley, PG TI Progression of calcified coronary atherosclerosis: Role of traditional risk factors, CRP, and non-calcified atherosclerosis SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 55th Annual Scientific Session of the American-College-of-Cardiology CY MAR 11-14, 2006 CL Atlanta, GA SP Amer Coll Cardiol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 21 PY 2006 VL 47 IS 4 SU A BP 127A EP 127A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 015CV UT WOS:000235530400549 ER PT J AU Javaheri, SP Shry, EA Casciello, MC Feig, J Rubal, BJ Sim, A AF Javaheri, SP Shry, EA Casciello, MC Feig, J Rubal, BJ Sim, A TI LDL control in patients undergoing peripheral arterial revascularization procedures compared to coronary arterial revascularization procedures SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 55th Annual Scientific Session of the American-College-of-Cardiology CY MAR 11-14, 2006 CL Atlanta, GA SP Amer Coll Cardiol C1 Brooke Army Med Ctr, San Antonio, TX USA. Brooks AFB, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 21 PY 2006 VL 47 IS 4 SU A BP 259A EP 259A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 015CV UT WOS:000235530401430 ER PT J AU Shi, JZ Reichenbach, SE Howe, JD AF Shi, JZ Reichenbach, SE Howe, JD TI Small-kernel superresolution methods for microscanning imaging systems SO APPLIED OPTICS LA English DT Article ID HIGH-RESOLUTION RECONSTRUCTION; CUBIC CONVOLUTION; RESTORATION; INTERPOLATION; REGISTRATION; FRAMES; ALGORITHM; IMAGES; NOISY AB Two computationally efficient methods for superresolution reconstruction and restoration of microscanning imaging systems are presented. Microscanning creates multiple low-resolution images with slightly different sample-scene phase shifts. The digital processing methods developed here combine the low-resolution images to produce an image with higher pixel resolution (i.e., superresolution) and higher fidelity. The methods implement reconstruction to increase resolution and restoration to improve fidelity in one-pass convolution with a small kernel. One method uses a small-kernel Wiener filter and the other method uses a parametric cubic convolution filter. Both methods are based on an end-to-end, continuous-discrete-continuous microscanning imaging system model. Because the filters are constrained to small spatial kernels they can be efficiently applied by convolution and are amenable to adaptive processing and to parallel processing. Experimental results with simulated imaging and with real microscanned images indicate that the small-kernel methods efficiently and effectively increase resolution and fidelity. (c) 2006 Optical Society of America. C1 Univ Nebraska, Dept Comp Sci & Engn, Lincoln, NE 68588 USA. USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Shi, JZ (reprint author), Univ Nebraska, Dept Comp Sci & Engn, Lincoln, NE 68588 USA. EM jshi@cse.unl.edu NR 35 TC 20 Z9 20 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 2006 VL 45 IS 6 BP 1203 EP 1214 DI 10.1364/AO.45.001203 PG 12 WC Optics SC Optics GA 016NX UT WOS:000235628000016 PM 16523783 ER PT J AU Somiari, SB Shriver, CD Heckman, C Olsen, C Hu, H Jordan, R Arciero, C Russell, S Garguilo, G Hooke, J Somiari, RI AF Somiari, SB Shriver, CD Heckman, C Olsen, C Hu, H Jordan, R Arciero, C Russell, S Garguilo, G Hooke, J Somiari, RI TI Plasma concentration and activity of matrix metalloproteinase 2 and 9 in patients with breast disease, breast cancer and at risk of developing breast cancer SO CANCER LETTERS LA English DT Article DE matrix metalloproteinase 2 and 9; breast cancer; high risk and Gail Model ID MATRIX METALLOPROTEINASES; FOLLOW-UP; EXPRESSION; CARCINOGENESIS; LOCALIZATION; METASTASIS; SWITCH; TUMORS AB Matrix metalloproteinases (MMPs) are involved in extracellular matrix modification and associated with invasive and metastatic behavior of human malignant tumors. Specifically, MMP2 and MMP9 are implicated in both early and late processes of tumor development. It is reported that MMPs occur as inactive precursors, active enzymes or enzyme inhibitor complexes in biological samples. However, there is limited knowledge on the role of each form in disease and/or the significance of changes in the plasma concentration and/or activity in breast cancer patients. The aim of this study was to determine if patients with breast cancer, benign disease and at risk for developing breast cancer display characteristic levels of active and/or total MMP2 and MMP9 in plasma. Concentration and activity of MMP2 and MMP9 were determined quantitatively in the plasma of 124 female volunteers diagnosed with breast cancer (n = 3 1), benign disease (n = 38), or determined by the Gail Model to be at high risk (n = 3 1) or low risk (controls, n = 24) of developing breast cancer. Data obtained was statistically analyzed to search for differences/patterns characteristic of each category. Concentration of total MMP2 was significantly lower in control individuals than benign, high risk (P < 0.001 respectively) and breast cancer patients (P=0.002). Activity of total MMP2 was significantly lower in controls compared to cancer, benign and high risk patients (P < 0.001 respectively). Attempts to build a predictive/descriptive model using canonical discriminant analysis (utilizing all eight features; concentrations and activity levels of active/total MMP2 and MMP9) enabled the distinction of the controls from the high risk, benign and cancer groups. Our results suggest that preoperative plasma concentration and activity of MMP2 and MMP9 may permit sub-classification of female patients with breast disorders. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Johnstown Breast Ctr, Johnstown, PA 15905 USA. ITSI Biosci, Funct Genom & Proteom Unit, Johnstown, PA 15904 USA. RP Somiari, SB (reprint author), Windber Res Inst, Clin Breast Care Project, 600 Somerset Ave, Windber, PA 15963 USA. EM s.somiari@wriwindber.org NR 22 TC 42 Z9 45 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3835 J9 CANCER LETT JI Cancer Lett. PD FEB 20 PY 2006 VL 233 IS 1 BP 98 EP 107 DI 10.1016/j.canlet.2005.03.003 PG 10 WC Oncology SC Oncology GA 019QH UT WOS:000235851300012 PM 16473671 ER PT J AU Yelleswarapu, CS Wu, PF Kothapalli, SR Rao, DVGLN Kimball, BR Sai, SSS Gowrishankar, R Sivaramakrishnan, S AF Yelleswarapu, CS Wu, PF Kothapalli, SR Rao, DVGLN Kimball, BR Sai, SSS Gowrishankar, R Sivaramakrishnan, S TI All-optical spatial filtering with power limiting materials SO OPTICS EXPRESS LA English DT Article ID BACTERIORHODOPSIN FILMS; ENHANCEMENT; FULLERENES; MODULATORS; LIQUID AB We demonstrated that a power limiting mechanism could potentially be used for self-adaptive, all-optical Fourier image processing. Reverse saturable absorbers like porphyrins are chosen due to their fluence dependent power limiting property, which triggers at relatively low intensities. At low input intensities, below the power-limiting threshold, the 4-f configuration will image the object onto the CCD camera without any spatial frequency filtering. As the input intensity is increased above the threshold level, dc and low spatial frequencies are blocked resulting in edge-enhanced images containing high spatial frequencies. The incident intensity sets the higher limit on the band of frequencies blocked. In addition, the use of the same experimental setup for both power limiting experiments and optical image processing demonstrates that in the case of any bright image bearing laser beam, the sensitive detectors are protected, by blocking the intense low spatial frequencies. (c) 2006 Optical Society of America. C1 Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. USA, Natick Soldier Ctr, Nanomat Sci Team, Natick, MA 01760 USA. Sri Sathya Sai Inst Higher Learning, Dept Phys, Prasanthinilayam 515134, India. RP Yelleswarapu, CS (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. EM raod@umb.edu RI Yelleswarapu, Chandra/C-4392-2011; Rao, Devulapalli/L-8863-2015 NR 24 TC 9 Z9 9 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 20 PY 2006 VL 14 IS 4 BP 1451 EP 1457 DI 10.1364/OE.14.001451 PG 7 WC Optics SC Optics GA 013QO UT WOS:000235424400013 PM 19503469 ER PT J AU Adams, BD Shih, H Stuffel, E Robinson, AM AF Adams, BD Shih, H Stuffel, E Robinson, AM TI A video based training program improves defibrillator inspection compliance SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article AB Improperly maintained defibrillators are an important cause of defibrillation delay or failure during in-hospital cardiac arrest. This study investigated whether a brief training video of how to properly inspect crash carts and defibrillators would improve the quality and frequency of these inspections. The study was a before-after cohort design. Crash cart inspection logs were explicitly examined, and the electronic archive records of the defibrillators; were interrogated. The compliance and quality of inspections were compared before and after the implementation of the training video program. The missed-inspection rate for defibrillators significantly improved from 8.9% to 6.9% (p = 0.037) after video training program implementation. The missed-inspection rate for crash carts, however, actually worsened from 2.7% before to 8.0% (p = 0.0001). The introduction of a new crash cart inspection training video program improved the frequency and quality of defibrillator inspections but not crash cart inspections. The inspection of crash carts and defibrillators is a vital hospital task. Because available training time for clinical personnel is limited, our 15-minute video can be viewed on a ward computer workstation at the most convenient time. (c) 2006 Elsevier Inc. All rights reserved. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Adams, BD (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM bruce.adams@amedd.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD FEB 15 PY 2006 VL 97 IS 4 BP 578 EP 579 DI 10.1016/j.amjcard.2005.09.090 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 014KP UT WOS:000235479200028 PM 16461060 ER PT J AU Xiong, YS Wiltsie, J Woods, A Guo, J Pivnichny, JV Tang, W Bansal, A Cummings, RT Cunningham, BR Friedlander, AM Douglas, CM Salowe, SP Zaller, DM Scolnick, EM Schmatz, DM Bartizal, K Hermes, JD MacCoss, M Chapman, KT AF Xiong, YS Wiltsie, J Woods, A Guo, J Pivnichny, JV Tang, W Bansal, A Cummings, RT Cunningham, BR Friedlander, AM Douglas, CM Salowe, SP Zaller, DM Scolnick, EM Schmatz, DM Bartizal, K Hermes, JD MacCoss, M Chapman, KT TI The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE anthrax; lethal factor; hydroxyamic acid ID SOLID-PHASE SYNTHESIS; HYDROXAMIC ACIDS; BACILLUS-ANTHRACIS; KINASE-KINASE; TOXIN; DESIGN; MACROPHAGES; LINKAGE; FACILE AB A potent and selective anthrax LF inhibitor 40, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, was identified through SAR study of a high throughput screen lead. It has an IC50 of 54 nM in the enzyme assay and an IC50 of 210 nM in the macrophage cytotoxicity assay. Compound 40 is also effective in vivo in several animal model studies. (c) 2005 Elsevier Ltd. All rights reserved. C1 Merck & Co Inc, Rahway, NJ 07065 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. MIT, Dept Bot, Cambridge, MA 02139 USA. RP Xiong, YS (reprint author), Merck & Co Inc, Rahway, NJ 07065 USA. EM yusheng_xiong@merck.com NR 29 TC 39 Z9 41 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD FEB 15 PY 2006 VL 16 IS 4 BP 964 EP 968 DI 10.1016/j.bmcl.2005.10.088 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 007CV UT WOS:000234946300043 PM 16338135 ER PT J AU Pritchett, TM AF Pritchett, TM TI Third-order electric susceptibility of nonpolar azimuthal molecular rotors mounted on a covalent polymer grid SO CHEMICAL PHYSICS LETTERS LA English DT Article ID DIPOLAR; FIELD; POLARIZABILITIES; SIMULATION; DYNAMICS; ROTATION; SURFACE AB Polyacene molecules are constrained to rotate about the principal axis associated with the diagonal component of the molecular polar-izability tensor that is intermediate in size. The rotation axes are oriented vertically ('azimuthal rotors') and are attached to a covalent monolayer grid such as that recently reported in the literature. We calculate the value of the relevant component of the third-order electric susceptibility of the system for a variety of grid spacings and determine that the optical nonlinearity of such a system is not particularly large, at best approaching that of carbon disulfide. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD, ARL,SE,EM, Adelphi, MD 20783 USA. RP Pritchett, TM (reprint author), USA, Res Lab, AMSRD, ARL,SE,EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM tpritchett@arl.army.mil NR 24 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD FEB 15 PY 2006 VL 419 IS 1-3 BP 288 EP 291 DI 10.1016/j.cplett.2005.11.068 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 013VU UT WOS:000235438900056 ER PT J AU Waibel, KH Golding, H Manischewitz, J King, LR Tuchscherer, M Topolski, RL Walsh, DS AF Waibel, KH Golding, H Manischewitz, J King, LR Tuchscherer, M Topolski, RL Walsh, DS TI Clinical and immunological comparison of smallpox vaccine administered to the outer versus the inner upper arms of vaccinia-naive adults SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID RESPONSES; VIRUS; PROTECTION; ANTIBODIES AB Background. Current recommendations direct health care providers to administer smallpox vaccine to the upper outer arm. However, concerns about cosmetically bothersome scarring, accidental contact transmission, interference by body tattoos, and even malignant transformation suggest evaluation of alternate vaccination sites is warranted. Methods. We randomized 20 vaccinia-naive adults to undergo smallpox vaccination on the outer (n=10) or inner (n=10) upper arm. Evaluations included major reaction ("take") rates and vaccination site cultures on postvaccination day 7, determination of serum vaccinia-specific neutralizing antibody titers on days 0 (prevaccination) and 21, and determination of adverse events. Results. On postvaccination day 7, a total of 18 participants ( 9 per group) had major reactions, 17 of whom had culture evidence of viable vaccinia. The inner and outer arm groups had similar major reaction mean sizes (P=.17), but the amount of erythema ( in square centimeters) was smaller in the inner arm group (P=.05). At day 21, all participants had higher titers of vaccinia-specific neutralizing antibodies, compared with at day 0, and the geometric mean titer values of the 2 vaccine groups were similar (P=.45). Adverse event rates were similar. Conclusion. The comparable clinical, immunological, and tolerability outcomes between smallpox vaccine applied to the conventional upper outer arm site versus the upper inner arm, coupled with modestly less vaccine-site erythema on the inner arm, indicate that the inner arm may be a suitable alternate vaccination site. C1 Dwight D Eisenhower Army Med Ctr, Dept Med, Allergy & Immunol Serv, Ft Gordon, GA 30905 USA. Dwight D Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA. Augusta State Univ, Dept Psychol, Augusta, GA USA. US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD USA. RP Waibel, KH (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Med, Allergy & Immunol Serv, 8th Fl,300 Hosp Rd, Ft Gordon, GA 30905 USA. EM kirk.waibel@se.amedd.army.mil NR 24 TC 6 Z9 6 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 15 PY 2006 VL 42 IS 4 BP E16 EP E20 DI 10.1086/499957 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 004HO UT WOS:000234742800034 PM 16421781 ER PT J AU Goodwin, RA Nestler, JM Anderson, JJ Weber, LJ Loucks, DP AF Goodwin, RA Nestler, JM Anderson, JJ Weber, LJ Loucks, DP TI Forecasting 3-D fish movement behavior using a Eulerian-Lagrangian-agent method (ELAM) SO ECOLOGICAL MODELLING LA English DT Review DE fish; movement rules; individual-based model; Eulerian; Lagrangian; agent; behavior ID INDIVIDUAL-BASED MODEL; HYDRAULIC FLOW SIMULATION; JUVENILE SALMON MIGRATION; MICHIGAN MOTTLED SCULPIN; LATERAL-LINE; LAKE-MICHIGAN; SPATIALLY EXPLICIT; HABITAT SELECTION; ATLANTIC SALMON; CHINOOK SALMON AB We describe a Eulerian-Lagrangian-agent method (ELAM) for mechanistically decoding and forecasting 3-D movement patterns of individual fish responding to abiotic stimuli. A ELAM model is an individual-based model (IBM) coupling a (1) Eulerian framework to govern the physical, hydrodynamic, and water quality domains, (2) Lagrangian framework to govern the sensory perception and movement trajectories of individual fish, and (3) agent framework to govern the behavior decisions of individuals. The resulting ELAM framework is well suited for describing large-scale patterns in hydrodynamics and water quality as well as the much smaller scales at which individual fish make movement decisions. This ability of ELAM models to simultaneously handle dynamics at multiple scales allows them to realistically represent fish movements within aquatic systems. We introduce ELAMs with an application to aid in the design and operation of fish passage systems in the Pacific Northwest, USA. Individual virtual fish make behavior decisions about every 2.0 s. These are sub-meter to meter-scale movements based on hydrodynamic stimuli obtained from a hydraulic model. Movement rules and behavior coefficients are systematically adjusted until the virtual fish movements approximate the observed fish. The ELAM model introduced in this paper is called the Numerical Fish Surrogate. It facilitated the development of a mechanistic biological-based hypothesis describing observed 3-D movement and passage response of downstream migrating juvenile salmon at 3 hydropower dams on 2 rivers with a total of 20 different structural and operational configurations. The Numerical Fish Surrogate is presently used by the U.S. Army Corps of Engineers and public utility districts during project planning and design to forecast juvenile salmon movement and passage response to alternative bypass structures. Published by Elsevier B.V. C1 Cornell Univ, USA, Engineer Res & Dev Ctr, CENWP,EC,HP, Portland, OR 97208 USA. USA, Engineer Res & Dev Ctr, Environm Modeling & Syst Wide Assessment Ctr, CEERD,IV,Z, Vicksburg, MS 39180 USA. Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA. Univ Iowa, IIHR Hydrosci & Engn, Stanley Hydraul Lab 100, Iowa City, IA 52242 USA. Cornell Univ, Ithaca, NY 14853 USA. RP Goodwin, RA (reprint author), Cornell Univ, USA, Engineer Res & Dev Ctr, CENWP,EC,HP, 333 SW 1st Ave,POB 2946, Portland, OR 97208 USA. EM rag12@cornell.edu; john.m.nestler@erdc.usace.army.mil; jim@cbr.washington.edu; larry-weber@uiowa.edu; DPL3@cornell.edu NR 130 TC 62 Z9 67 U1 2 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD FEB 15 PY 2006 VL 192 IS 1-2 BP 197 EP 223 DI 10.1016/j.ecolmodel.2005.08.004 PG 27 WC Ecology SC Environmental Sciences & Ecology GA 014XD UT WOS:000235512900013 ER PT J AU Roy, S Zorman, C Mehregany, M DeAnna, R Deeb, C AF Roy, S Zorman, C Mehregany, M DeAnna, R Deeb, C TI The mechanical properties of polycrystalline 3C-SiC films grown on polysilicon substrates by atmospheric pressure chemical-vapor deposition SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THERMAL-EXPANSION; RESIDUAL-STRESS; SILICON-CARBIDE; ELASTIC-MODULUS; DEFORMATION AB This paper presents the results of a study to determine Young's modulus, residual stress, and burst strength of polycrystalline 3C silicon carbide (poly-SiC) films grown on as-deposited and annealed polysilicon substrate layers. The biaxial modulus and residual stress were determined for bulk micromachined poly-SiC diaphragms using an interferometric load-deflection measurement apparatus. The load-deflection data were analyzed using a least-squares fitting technique to extract the biaxial modulus and residual stress values, and Young's modulus was calculated assuming a Poisson ratio of 0.15. Poly-SiC films comprised of equiaxed grains exhibited Young's modulus values ranging from 452 to 494 GPa, while columnar films with a high degree of (110) texture exhibited Young's modulus values between 340 and 357 GPa. The residual stress for these films did not exhibit a discernable relationship with microstructure; however, the values exhibited a general dependence on growth temperature. Poly-SiC films grown at 1280 degrees C had residual stress values ranging from 401 to 486 MPa, while a film grown at 1160 degrees C had a residual stress value of 113 MPa. Burst strength was determined using a combination of finite element analysis and burst pressure measurements of the suspended diaphragms. Poly-SiC films grown at 1280 degrees C exhibited an average burst strength value of 1718 MPa, while the poly-SiC film grown at 1160 degrees C had an average burst strength value of 1321 MPa. (c) 2006 American Institute of Physics. C1 Case Western Reserve Univ, Dept Elect Engn & Comp Sci, Cleveland, OH 44106 USA. NASA, Glenn Res Ctr Lewis Field, USA, Res Lab, Cleveland, OH 44135 USA. Case Western Reserve Univ, Dept Mat Sci & Engn, Cleveland, OH 44106 USA. RP Roy, S (reprint author), Case Western Reserve Univ, Dept Elect Engn & Comp Sci, Cleveland, OH 44106 USA. EM christian.zorman@case.edu OI Zorman, Christian/0000-0001-9773-9351 NR 28 TC 24 Z9 25 U1 1 U2 11 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 2006 VL 99 IS 4 AR 044108 DI 10.1063/1.2169875 PG 13 WC Physics, Applied SC Physics GA 016ZF UT WOS:000235663100044 ER PT J AU Hartmann, JE AF Hartmann, JE TI Neurology in Operation Iraqi Freedom: Risk factors for referral, clinical presentations and incidence of disease SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article DE military; neurology; incidence; risk factors; Operation Iraqi Freedom AB Six hundred and sixteen patients were referred for consultation to the author who served as the neurologist on the 252nd Neurosurgical Team in Kuwait in support of Operation Iraqi Freedom between April and October, 2003. Demographic and military data were collected. The cohort of neurologic patients showed significant differences from the total population of the United States Army contemporarily deployed to Operation Iraqi Freedom. Versus the deployed personnel, the neurologic cohort was older in age (p < 0.001), had a greater percentage of females (p < 0.00001), had an excessive representation for the military rank of sergeant (p < 0.00001), with a deficit of other ranks (junior enlisted and officers), and were more likely to soldiers from the Reserves (p < 0.00001) and National Guard (p=0.0021) than from the Regular Army. Seven categories of chief complaints and ten categories of diagnoses constituted some 80% of patients. The incidence of neurologic disease was calculated to be 634 per 100,000 people/year. This information provides valuable information for military neurologists concerning their anticipated duties in future deployments and for non-neurologists by focusing their skills in the evaluation of common neurologic presentations, yet further research is needed to optimize the neurologist's role in a field environment. Published by Elsevier B.V. C1 Tripler Army Med Ctr, Serv Neurol, Honolulu, HI 96859 USA. RP Hartmann, JE (reprint author), Tripler Army Med Ctr, Serv Neurol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.edward.hartmann@us.army.mil NR 4 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD FEB 15 PY 2006 VL 241 IS 1-2 BP 83 EP 90 DI 10.1016/j.jns.2005.11.002 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 011CS UT WOS:000235245900013 PM 16343543 ER PT J AU Ruffing, JA Cosman, F Zion, M Tendy, S Garrett, P Lindsay, R Nieves, JW AF Ruffing, J. A. Cosman, F. Zion, M. Tendy, Susan Garrett, P. Lindsay, R. Nieves, J. W. TI Determinants of bone mass and bone size in a large cohort of physically active young adult men SO NUTRITION & METABOLISM LA English DT Article ID MINERAL DENSITY; CALCIUM INTAKE; RISK-FACTORS; ENVIRONMENTAL DETERMINANTS; CIGARETTE-SMOKING; FRACTURE RISK; BODY-WEIGHT; OSTEOPOROSIS; WOMEN; CHILDREN AB The determinants of bone mineral density (BMD) at multiple sites were examined in a fit college population. Subjects were 755 males ( mean age = 18.7 years) entering the United States Military Academy. A questionnaire assessed exercise frequency and milk, caffeine, and alcohol consumption and tobacco use. Academy staff measured height, weight, and fitness. Calcaneal BMD was measured by peripheral dual-energy x-ray absorptiometry (pDXA). Peripheral-quantitative computed tomography (pQCT) was used to measure tibial mineral content, circumference and cortical thickness. Spine and hip BMD were measured by DXA in a subset ( n = 159). Mean BMD at all sites was approximately one standard deviation above young normal ( p < 0.05). African Americans had significantly higher hip, spine and heel BMD and greater tibial mineral content and cortical thickness than Caucasians and Asians. In Caucasians ( n = 653), weight was a significant determinant of BMD at every skeletal site. Prior exercise levels and milk intake positively related to bone density and size, while caffeine had a negative impact. There was an apparent interaction between milk and exercise in BMD at the heel, spine, hip and tibial mineral content and cortical thickness. Our data confirm the importance of race, body size, milk intake and duration of weekly exercise as determinants of BMD and bone size. C1 Helen Hayes Hosp, Clin Res Ctr, W Haverstraw, NY 10993 USA. Helen Hayes Hosp, Reg Bone Ctr, W Haverstraw, NY USA. Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA. Columbia Univ Coll Phys & Surg, Dept Epidemiol, New York, NY 10032 USA. US Mil Acad, West Point, NY 10996 USA. RP Nieves, JW (reprint author), Helen Hayes Hosp, Clin Res Ctr, W Haverstraw, NY 10993 USA. EM jamie.ruffing@us.army.mil; cosmanf@helehhayeshosp.org; zionm@helenhayeshosp.org; Susan.Tendy@usma.edu; garrettp@helenhayeshosp.org; lindsayr@helehhayeshosp.org; nievesj@helenhayeshosp.org NR 47 TC 21 Z9 23 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1743-7075 J9 NUTR METABOLISM JI Nutr. Metab. PD FEB 15 PY 2006 VL 3 AR 14 DI 10.1186/1743-7075-3-14 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 065BN UT WOS:000239134500001 PM 16480509 ER PT J AU Chilcott, RP Dalton, CH Hattersley, IJ Rutter, SJ Graham, JS AF Chilcott, RP Dalton, CH Hattersley, IJ Rutter, SJ Graham, JS TI Infrared imaging for the non-invasive assessment of chemical burns: A preliminary study SO TOXICOLOGY LA English DT Meeting Abstract CT Autumn Meeting of the British-Toxicology-Society CY SEP 19-20, 2005 CL Univ Bath, Bath, ENGLAND SP British Toxicol Soc HO Univ Bath C1 Chem Hazards & Poisons Div HQ, Hlth Protect Agcy, Didcot OX11 0RQ, Oxon, England. Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM rob.chilcott@hpa.org.uk NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD FEB 15 PY 2006 VL 219 IS 1-3 BP 239 EP 240 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 011WQ UT WOS:000235299700038 ER PT J AU Lisal, M Brennan, JK Smith, WR AF Lisal, M Brennan, JK Smith, WR TI Chemical reaction equilibrium in nanoporous materials: NO dimerization reaction in carbon slit nanopores SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID REACTION ENSEMBLE METHOD; MONTE-CARLO SIMULATIONS; 4 BONDING SITES; MOLECULAR-DYNAMICS; COMPUTER-SIMULATION; ASSOCIATING FLUIDS; CONFINED SYSTEMS; PHASE-EQUILIBRIA; POROUS MATERIALS; PORES AB We present a molecular-level simulation study of the effects of confinement on chemical reaction equilibrium in nanoporous materials. We use the reaction ensemble Monte Carlo (RxMC) method to investigate the effects of temperature, nanopore size, bulk pressure, and capillary condensation on the nitric oxide dimerization reaction in a model carbon slit nanopore in equilibrium with a bulk reservoir. In addition to the RxMC simulations, we also utilize the molecular-dynamics method to determine self-diffusion coefficients for confined nonreactive mixtures of nitric oxide monomers and dimers at compositions obtained from the RxMC simulations. We analyze the effects of the temperature, nanopore width, bulk pressure, and capillary condensation on the reaction equilibrium with respect to the reaction conversion, fluid structure, and self-diffusion coefficients. We show that the influence of the temperature, nanopore size, and capillary condensation on the confined reaction equilibrium is quite dramatic while the effect of the bulk pressure on the reaction equilibrium in the carbon slit nanopore is only moderate. This work is an extension of previous work by Turner et al. [J. Chem. Phys. 114, 1851 (2001)] on the confined reactive nitric oxide system. (c) 2006 American Institute of Physics. C1 Acad Sci Czech Republic, E Hala Lab Thermodynam, Inst Chem Proc Fundamentals, CR-16502 Prague, Czech Republic. Univ JE Purkyne, Dept Phys, Inst Sci, Usti Nad Labem 40096, Czech Republic. USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Univ Ontario, Inst Technol, Fac Sci, N Oshawa, ON L1H 7K4, Canada. RP Lisal, M (reprint author), Acad Sci Czech Republic, E Hala Lab Thermodynam, Inst Chem Proc Fundamentals, Rozvojova 135,6 Suchdol, CR-16502 Prague, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Smith, William/G-4404-2010 OI Lisal, Martin/0000-0001-8005-7143; Smith, William/0000-0002-1982-2050 NR 44 TC 19 Z9 19 U1 2 U2 11 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 14 PY 2006 VL 124 IS 6 AR 064712 DI 10.1063/1.2171213 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 012AA UT WOS:000235309400046 PM 16483234 ER PT J AU Cadarette, BS Cheuvront, SN Kolka, MA Stephenson, LA Montain, SJ Sawka, MN AF Cadarette, BS Cheuvront, SN Kolka, MA Stephenson, LA Montain, SJ Sawka, MN TI Intermittent microclimate cooling during exercise-heat stress in US army chemical protective clothing SO ERGONOMICS LA English DT Article DE personal cooling; heat strain; chemical protective clothing; human ID WORK; SYSTEMS; THERMOREGULATION; INDEX; DEBT; COLD; AIR AB The effectiveness of intermittent, microclimate cooling for men who worked in US Army chemical protective clothing (modified mission-oriented protective posture level 3; MOPP 3) was examined. The hypothesis was that intermittent cooling on a 2min on-off schedule using a liquid cooling garment (LCG) covering 72% of the body surface area would reduce heat strain comparably to constant cooling. Four male subjects completed three experiments at 30 degrees C, 30% relative humidity wearing the LCG under the MOPP3 during 80min of treadmill walking at 224 +/- 5 W (.) m(-2). Water temperature to the LCG was held constant at 21 degrees C. The experiments were; 1) constant cooling (CC); 2) intermittent cooling at 2-min intervals (IC); 3) no cooling (NC). Core temperature increased (1.6 +/- 0.2 degrees C) in NC, which was greater than IC (0.5 +/- 0.2 degrees C) and CC ( 0.5 +/- 0.3 degrees C) (p < 0.05). Mean skin temperature was higher during NC (36.1 +/- 0.4 degrees C) than IC ( 33.7 +/- 0.6 degrees C) and CC (32.6 +/- 0.6 degrees C) and mean skin temperature was higher during IC than CC (p < 0.05). Mean heart rate during NC (139 +/- 9 b (.) min(-1)) was greater than IC ( 110 +/- 10 b (.) min(-1)) and CC ( 107 +/- 9 b (.) min(-1)) (p < 0.05). Cooling by conduction (K) during NC (94 +/- 4 W (.) m(-2)) was lower than IC ( 142 +/- 7 W (.) m(-2)) and CC ( 146 +/- 4 W (.) m(-2)) (p < 0.05). These findings suggest that IC provided a favourable skin to LCG gradient for heat dissipation by conduction and reduced heat strain comparable to CC during exercise-heat stress in chemical protective clothing. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Cadarette, BS (reprint author), USA, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM bruce.cadarette@us.army.mil NR 23 TC 26 Z9 28 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD FEB 10 PY 2006 VL 49 IS 2 BP 209 EP 219 DI 10.1080/00140130500436136 PG 11 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 011OD UT WOS:000235277000007 PM 16484146 ER PT J AU Li, SQ Zhang, HQ Balasubramaniam, VM Lee, YZ Bomser, JA Schwartz, SJ Dunne, CP AF Li, SQ Zhang, HQ Balasubramaniam, VM Lee, YZ Bomser, JA Schwartz, SJ Dunne, CP TI Comparison of effects of high-pressure processing and heat treatment on immunoactivity of bovine milk immunoglobulin G in enriched soymilk under equivalent microbial inactivation levels SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE high-pressure processing; bovine milk IgG; immunoactivity; E. coli 8739; natural flora ID PULSED ELECTRIC-FIELDS; ANTIGEN-BINDING ACTIVITY; ESCHERICHIA-COLI; THERMAL PROTECTANTS; G IGG; STABILITY; COLOSTRUM; CRYPTOSPORIDIOSIS; CONCENTRATE; CHALLENGE AB Immunoglobulin-rich foods may provide health benefits to consumers. To extend the refrigerated shelf life of functional foods enriched with bovine immunoglobulin G (IgG), nonthermal alternatives such as high-pressure processing (HPP) may offer advantages to thermal processing for microbial reduction. To evaluate the effects of HPP on the immunoactivity of bovine IgG, a soymilk product enriched with milk protein concentrates, derived from dairy cows that were hyperimmunized with 26 human pathogens, was subjected to HPP or heat treatment. To achieve a 5 log reduction in inoculated Escherichia coli 8739, the HIPP or heat treatment requirements were 345 MPa for 4 min at 30 degrees C or for 20 s at 70 degrees C, respectively. To achieve a 5 log reduction in natural flora in the enriched soymilk, the HIPP or heat treatments needed were 552 MPa for 4 min at 30 degrees C or for 120 s at 78.2 degrees C, respectively. At equivalent levels for a 5 log reduction in E coli, HIPP and heat treatment caused 25% and no detectable loss in bovine IgG activity, respectively. However, at equivalent levels for a 5 log reduction in natural flora, HPP and heat resulted in 65 and 85% loss of bovine IgG activity, respectively. Results of combined pressure -thermal kinetic studies of bovine milk IgG activity were provided to determine the optimal process conditions to preserve product function. C1 Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA. USDA, Eastern Reg Res Ctr, Food Safety Intervent Technol, Wyndmoor, PA 19038 USA. Biofoods Stolle Milk & Biol Inc, Cincinnati, OH 45242 USA. Ohio State Univ, Dept Human Nutr, Columbus, OH 43210 USA. USA, Natick Soldier Syst Ctr, Natick, MA 01760 USA. RP Zhang, HQ (reprint author), Ohio State Univ, Dept Food Sci & Technol, 110 Parker Bldg,2015 Fyffe Rd, Columbus, OH 43210 USA. EM hzhang@errc.ars.usda.gov RI Balasubramaniam, VM Bala/A-2576-2008; OI Balasubramaniam, VM Bala/0000-0002-1540-4273; Schwartz, Steven/0000-0002-1427-5780 NR 36 TC 15 Z9 16 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD FEB 8 PY 2006 VL 54 IS 3 BP 739 EP 746 DI 10.1021/jf0516181 PG 8 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 011EC UT WOS:000235249800022 PM 16448177 ER PT J AU Shah, BK Neckers, DC Shi, JM Forsythe, EW Morton, D AF Shah, BK Neckers, DC Shi, JM Forsythe, EW Morton, D TI Anthanthrene derivatives as blue emitting materials for organic light-emitting diode applications SO CHEMISTRY OF MATERIALS LA English DT Article ID MOIETY; YIELDS AB Photophysical properties of anthanthrene (1) and its derivatives (2-11) substituted at the 4,10 and/or 6,12 positions (phi(F) = 0.25-0.56, tau(F) = 2.93-4.21 ns in CH2Cl2) are compared. Solution emission behavior (lambda(max) = 438-482 nm) is similar to that observed in the solid state (lambda(max) = 437-465 nm). The compounds are shown to be efficient and very stable blue emitters, especially in the solid state (phi(F) = 0.39-0.86). An electroluminescent (EL) device containing 5 as a dopant produced an EL efficiency of 3.0 cd/A with CIE coordinates of 0.13 and 0.25. The luminescence half-life of the device was more than 3500 It with an initial luminescence similar to 600 cd/m(2). C1 Bowling Green State Univ, Ctr Photochem Sci, Bowling Green, OH 43403 USA. USA, Res Lab, AMSRD SE EO, Adelphi, MD 20783 USA. RP Shah, BK (reprint author), Bowling Green State Univ, Ctr Photochem Sci, Bowling Green, OH 43403 USA. EM bipin@bgnet.bgsu.edu; neckers@photo.bgsu.edu; jshi@arl.army.nul NR 21 TC 54 Z9 56 U1 0 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD FEB 7 PY 2006 VL 18 IS 3 BP 603 EP 608 DI 10.1021/cm052188x PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 010HB UT WOS:000235177100006 ER PT J AU Boieriu, P Grein, CH Velicu, S Garland, J Fulk, C Sivananthan, S Stoltz, A Bubulac, L Dinan, JH AF Boieriu, P Grein, CH Velicu, S Garland, J Fulk, C Sivananthan, S Stoltz, A Bubulac, L Dinan, JH TI Effects of hydrogen on majority carrier transport and minority carrier lifetimes in long wavelength infrared HgCdTe on Si SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; DEEP-LEVEL; PASSIVATION; CRYSTALS AB We present the results of using an electron cyclotron resonance (ECR) plasma to incorporate hydrogen into long wavelength infrared HgCdTe layers grown by molecular beam epitaxy. Both as-grown and annealed layers doped in situ with indium were hydrogenated. Secondary ion mass spectroscopy confirmed the incorporation of hydrogen. Hall and photoconductive lifetime measurements were used to assess the effects of the hydrogenation. Increases in the electron mobilities and minority carrier lifetimes were observed for almost all ECR conditions. (c) 2006 American Institute of Physics. C1 EPIR Technol Inc, Bolingbrook, IL 60440 USA. USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Boieriu, P (reprint author), EPIR Technol Inc, Bolingbrook, IL 60440 USA. NR 18 TC 12 Z9 14 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 6 PY 2006 VL 88 IS 6 AR 062106 DI 10.1063/1.2172295 PG 3 WC Physics, Applied SC Physics GA 011FF UT WOS:000235252800051 ER PT J AU Killgore, WDS Yurgelun-Todd, DA AF Killgore, WDS Yurgelun-Todd, DA TI Ventromedial prefrontal activity correlates with depressed mood in adolescent children SO NEUROREPORT LA English DT Article DE adolescence; anterior cingulate; depression; development; functional magnetic resonance imaging; limbic system; mood neuroimaging; ventromedial prefrontal cortex ID MAJOR DEPRESSION; NEURAL RESPONSE; BRAIN ACTIVITY; FMRI; SADNESS; SELF; HAPPINESS; FEELINGS; EMOTION; CORTEX AB In adults, the medial prefrontal cortex and anterior cingulate gyrus are preferentially activated during emotion-related processes, including normal sadness and pathological depression. It is not clear, however, whether similar regional activity is also characteristic of depressed mood during adolescence. We correlated whole brain activity during a fear face perception task with scores on the Beck Depression Inventory in 16 adolescents undergoing functional magnetic resonance imaging. After controlling for age, depressed mood scores correlated with increased activity within the ventromedial prefrontal cortex and rostral anterior cingulate gyrus, consistent with findings previously reported for sadness and depression in adults, suggesting that the neural substrates of depressed mood are established early in life and remain relatively consistent across development into adulthood. C1 Harvard Univ, McLean Hosp, Sch Med, Cognit Neuroimaging Lab, Belmont, MA 02178 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM killgore@mclean.harvard.edu FU NICHD NIH HHS [IR03 HD41542-01] NR 25 TC 38 Z9 38 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD FEB 6 PY 2006 VL 17 IS 2 BP 167 EP 171 DI 10.1097/01.wnr.0000198951.30939.73 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 012OZ UT WOS:000235349800012 PM 16407765 ER PT J AU Shivachandra, SB Rao, M Janosi, L Sathaliyawala, T Matyas, GR Alving, CR Leppla, SH Rao, VB AF Shivachandra, SB Rao, M Janosi, L Sathaliyawala, T Matyas, GR Alving, CR Leppla, SH Rao, VB TI In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: A strategy for efficient display of large full-length proteins SO VIROLOGY LA English DT Article DE bacteriophage T4; virus assembly; Hoc; phage display; protective antigen; vaccine ID BACILLUS-ANTHRACIS; LETHAL FACTOR; PHAGE; EXPRESSION; LAMBDA; SOC; PURIFICATION; PEPTIDES; MUTANTS; VECTOR AB An in vitro binding system is described to display large full-length proteins on bacteriophage T4 capsid surface at high density. The phage T4 icosahedral capsid features 155 copies of a nonessential highly antigenic outer capsid protein, Hoc, at the center of each major capsid protein hexon. Gene fusions were engineered to express the 83-kDa protective antigen (PA) from Bacillus anthracis fused to the N-terminus of Hoc and the 130-kDa PA-Hoc protein was expressed in Escherichia coli and purified. The purified PA-Hoc was assembled in vitro on hoc(-) phage particles. Binding was specific, stable, and of high affinity. This defined in vitro system allowed manipulation of the copy number of displayed PA and imposed no significant limitation on the size of the displayed antigen. In contrast to in vivo display systems, the in vitro approach allows all the capsid binding sites to be occupied by the 130-kDa PA-Hoc fusion protein. The PA-T4 particles were immunogenic in mice in the absence of an adjuvant, eliciting strong PA-specific antibodies and anthrax lethal toxin neutralizing antibodies. The in vitro display on phage T4 offers a novel platform for potential construction of customized vaccines against anthrax and other infectious diseases. (C) 2005 Elsevier Inc. All rights reserved. C1 Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD 20910 USA. NIAID, Bacterial Toxins & Therapuet Sect, NIH, Bethesda, MD 20892 USA. RP Rao, VB (reprint author), Catholic Univ Amer, Dept Biol, 103 McCort Ward Hall,620 Michigan Ave NE, Washington, DC 20064 USA. EM rao@cua.edu OI Matyas, Gary/0000-0002-2074-2373 FU NIAID NIH HHS [AI056443] NR 35 TC 29 Z9 32 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 5 PY 2006 VL 345 IS 1 BP 190 EP 198 DI 10.1016/j.virol.2005.10.037 PG 9 WC Virology SC Virology GA 009MV UT WOS:000235117000019 PM 16316672 ER PT J AU Marshall, DA Vernalis, MN Remaley, AT Walizer, EM Scally, JP Taylor, AJ AF Marshall, DA Vernalis, MN Remaley, AT Walizer, EM Scally, JP Taylor, AJ TI The role of exercise in modulating the impact of an ultralow-fat diet on serum lipids and apolipoproteins in patients with or at risk for coronary artery disease SO AMERICAN HEART JOURNAL LA English DT Article ID LIFE-STYLE CHANGES; DENSITY-LIPOPROTEIN CHOLESTEROL; HEART-DISEASE; CARDIOVASCULAR-DISEASE; PLASMA-LIPOPROTEINS; BLOOD-LIPIDS; CARBOHYDRATE AB Background Ultralow-fat diets are known to reduce high-density lipoprotein cholesterol (HDL-C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL-C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods We performed a 3-month, prospective, nonrandomized lifestyle intervention study (<= 10% dietary fat; aerobic exercise [180 min/wk], group support, and yoga [60 min/d]) in 120 subjects with or at risk for coronary artery disease. Results After 3 months, dietary fat intake was reduced to 8.7% +/- 2.6% of total intake and the median weekly exercise time was 194 minutes. High-density lipoprotein cholesterol levels decreased by 8.3 +/- 11.3 mg/dL (P <.001), and triglyceride levels increased by 17.6 +/- 102.7 mg/dL (P =.026). A small dense low-density lipoprotein cholesterol (LDL-C) phenotype emerged indicated by a 13.8% LDL-C reduction accompanied by only a 2.3% reduction in apolipoprotein B levels (P =.064). Among subjects with exercise amounts less than those of the group median, HDL-C reductions were greater in those with more than (-13.5 +/- 16.0 mg/dL) versus less than (-2.5 +/- 7.5 mg/dl) the median reductions in fat intake (P =.026). Even among subjects who exercised > 194 min/wk, HDL-C was reduced compared with baseline (-7.4 +/- 7.9 mg/dL, P <.001). Conclusions An ultralow-fat diet as a component of a comprehensive lifestyle intervention induces reductions in HDL-C and the emergence of a dyslipidemic lipid profile. Aerobic exercise only partially mitigates this effect. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. NIH, Dept Lab Med, Bethesda, MD 20892 USA. RP Marshall, DA (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave,NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM debra.marshall@na.amedd.army.mil NR 21 TC 7 Z9 7 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD FEB PY 2006 VL 151 IS 2 BP 484 EP 491 DI 10.1016/j.ahj.2005.03.065 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 014ZG UT WOS:000235521100034 PM 16442919 ER PT J AU Barker, KB Palekar, NA Bowers, SP Goldberg, JE Pulcini, JP Harrison, SA AF Barker, KB Palekar, NA Bowers, SP Goldberg, JE Pulcini, JP Harrison, SA TI Non-alcoholic steatohepatitis: Effect of Roux-en-Y gastric bypass surgery SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID FATTY LIVER-DISEASE; WEIGHT-LOSS; OBESE-PATIENTS; ABNORMALITIES; REDUCTION AB OBJECTIVE: Non-alcoholic steatohepatitis (NASH) is an increasingly prevalent problem. Treatment options are still under investigation. The primary aim of the study was to determine whether weight loss, achieved through Roux-en-Y gastric bypass (RYGBP), improved histopathology in obese patients with biopsy proven NASH. METHODS: One hundred and forty-nine patients were identified from a surgical database as having RYGBP for obesity and concomitant intra-operative liver biopsies from October 2001 to September 2003. Thirty-five patients were found to have evidence of NASH at the time of surgery. Nineteen patients were contacted and underwent repeat percutaneous liver biopsies. Biopsies were evaluated and compared in blinded fashion by an experienced hepatopathologist. Fasting lipid panel, insulin and glucose, hemoglobin A1c (HgbA1c), and liver enzymes were obtained. RESULTS: Significant differences were noted in the following variables pre- and post-bypass surgery: body mass index 46.8-28.8 kg/m(2) (p < 0.001); body weight in kilograms 132.1-79.7 (p < 0.001); glucose 102.9-94.1 mg/dL (p= 0.015); Hgb A1c 5.79-5.15% (p= 0.026); high density lipoprotein 45.7-64.4 mg/dL (p < 0.001); low density lipoprotein 112-88.6 mg/dL (p= 0.003); triglycerides 132.1-97 mg/dL (p= 0.013). Significant improvements in steatosis, lobular inflammation, portal, and lobular fibrosis were noted. Histopathologic criteria for NASH were no longer found in 17/19 patients (89%). CONCLUSIONS: Weight loss after gastric bypass surgery in obese patients with NASH results in significant improvement in glucose, HgbA1c. and lipid profiles. Furthermore, RYGBP results in significant improvement in the histological features of NASH with resolution of disease in a majority of these patients. C1 Wilford Hall USAF Med Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. Dept Gastroenterol, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 19 TC 102 Z9 102 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD FEB PY 2006 VL 101 IS 2 BP 368 EP 373 DI 10.1111/j.1572-0241.2006.00419.x PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 008KV UT WOS:000235040500028 PM 16454845 ER PT J AU Fonseca, DM Smith, JL Wilkerson, RC Fleischer, RC AF Fonseca, DM Smith, JL Wilkerson, RC Fleischer, RC TI Pathways of expansion and multiple introductions illustrated by large genetic differentiation among worldwide populations of the southern house mosquito SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LIBERIAN CULEX-QUINQUEFASCIATUS; AVIAN MALARIA; WUCHERERIA-BANCROFTI; MICROSATELLITE LOCI; PIPIENS COMPLEX; NORTH-AMERICA; SUSCEPTIBILITY; VECTOR; HAWAII; CULICIDAE AB The southern house mosquito Cidex quinquefasciatus is a principal vector of human lymphatic filariasis, several encephalitides (including West Nile virus), avian malaria, and poxvirus, but its importance as it vector varies considerably among regions. This species has spread with humans and is ubiquitous in tropical urban and suburban environments. This was the first mosquito to reach Hawaii and we performed a worldwide genetic survey using microsatellite loci to identify its source. Our analyses showed divergent Old World and New World genetic signatures in Cx. quinquefasciatus with further distinctions between cast and west African, Asian, and Pacific populations that correlate with the epidemiology of human filariasis. We found that in Hawaii south Pacific mosquitoes have largely replaced the original New World introduction of Cx. quinquefasciatus, consistent with their reported expansion to higher elevations. We hypothesize worldwide pathways of expansion of this disease vector. C1 Acad Nat Sci Philadelphia, Philadelphia, PA 19103 USA. Smithsonian Inst, Genet Program, Washington, DC 20560 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Fonseca, DM (reprint author), Acad Nat Sci Philadelphia, 1900 Ben Franklin Pkwy, Philadelphia, PA 19103 USA. EM fonseca@acnatsci.org RI Meyer, Julie/D-1021-2010; OI Meyer, Julie/0000-0003-3382-3321; Fonseca, Dina/0000-0003-4726-7100 FU NIGMS NIH HHS [R01GM063258]; PHS HHS [U50/CCU220532] NR 47 TC 42 Z9 45 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2006 VL 74 IS 2 BP 284 EP 289 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 012OX UT WOS:000235349600019 PM 16474085 ER PT J AU Ryan, JR Mbui, J Rashid, JR Wasunna, MK Kirigi, G Magiri, C Kinoti, D Ngumbi, PM Martin, SK Odera, SO Hochberg, LP Bautista, CT Chan, AST AF Ryan, JR Mbui, J Rashid, JR Wasunna, MK Kirigi, G Magiri, C Kinoti, D Ngumbi, PM Martin, SK Odera, SO Hochberg, LP Bautista, CT Chan, AST TI Spatial clustering and epidemiological aspects of visceral leishmaniasis in two endemic villages, Baringo District, Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article; Proceedings Paper CT 51st Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 10-14, 2002 CL DENVER, CO SP Amer Soc Trop Med & Hyg ID LINKED-IMMUNOSORBENT-ASSAY; DIRECT AGGLUTINATION-TEST; KALA-AZAR; CUTANEOUS LEISHMANIASIS; PHLEBOTOMINE SANDFLIES; RIFT-VALLEY; CLINICAL MANIFESTATIONS; ELISA; SERODIAGNOSIS; INSECTICIDE AB Visceral leishmaniasis (VL) seroprevalence in Kenya is unknown because of the lack of a practical and accurate diagnostic test or Surveillance system. A novel serological assay was used to estimate the seroprevalence of Leishmania-specific antibodies, and Global Information System and spatial clustering techniques were applied to the presence of spatial clusters in Parkarin and Loboi villages in Baringo District in 2001. VL seroprevalences were 52.5% in Parkarin and 16.9% in Loboi. Significant associations among seropositivity and house construction, age, and proximity to domestic animal enclosures were found. A significant spatial cluster of VL was found in Loboi. The spatial distribution of cases in the two villages was different with respect to risk factors, such as presence of domestic animals. This study suggests that disease control efforts could be focused on elimination of sand fly habitat, placement of domestic animal enclosures, and targeted use of insecticides. C1 Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. USA, Med Res Unit, Nairobi 64109, Kenya. Kenya Govt Med Res Ctr, Clin Res Ctr, Nairobi, Kenya. US Mil HIV Res Program, Rockville, MD USA. Henry M Jackson Fdn Advancement Mil Med Inc, Rockville, MD USA. RP Chan, AST (reprint author), Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM adeline.chan@na.amedd.army.mil RI Bautista, Christian/B-2812-2011 NR 49 TC 23 Z9 26 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2006 VL 74 IS 2 BP 308 EP 317 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 012OX UT WOS:000235349600023 PM 16474089 ER PT J AU Jackson, WL Shorr, AF AF Jackson, WL Shorr, AF TI The yield of lumbar puncture to exclude nosocomial meningitis as aetiology for mental status changes in the medical intensive care unit SO ANAESTHESIA AND INTENSIVE CARE LA English DT Article DE central nervous system; fever; intensive care unit; lumbar puncture; meningitis; nosocomial infection ID CRITICALLY-ILL PATIENTS; MECHANICAL VENTILATION; RETROSPECTIVE ANALYSIS; BACTERIAL-MENINGITIS; ADULTS AB We aimed to evaluate the diagnostic value of lumber puncture in excluding nosocomial meningitis as the cause of mental status changes in medical intensive care unit patients. We retrospectively reviewed the records of all patients admitted to the medical intensive care unit at out, institution over a four-year period who had a lumbar puncture performed during their stay. Patients with central nervous system devices were excluded. During the study period 63 lumber punctures were performed, 31 to exclude nosocomial meningitis. Of these 31 patients, 25 (80.6%) received antimicrobials during hospitalization before performance of lumbar puncture. In one patient with human immunodeficiency virus (HIV) infection, Grain stain demonstrated yeast; in the remainder, Grant stain was negative. Cultures were negative for pathogenic bacteria in all 30 of these patients (overall yield: 0%, 95% CP 0-10.0%). Fivepatients (16.1%) had a cerebrospinal fluid leucocytosis (> 10 leukocytes/mm(3)); of these, all had received prior antibiotics, two had positive ctyptococcal antigen results, and three had central nervous system infection suspected clinically without an evident alternative diagnosis. In no non-HIV subject did lumbar puncture alter management. Lumbar puncture performed in the medical intensive care unit to exclude nosocomial meningitis as the cause Of mental status changes has a low yield. and rarely changes management. These findings should not be generalized to patients who have sustained head trauma, have undergone neurosurgical procedures, or may be immunosuppressed. C1 Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med Serv, Dept Med, Washington, DC USA. RP Jackson, WL (reprint author), Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Bldg 2,Room 3M12,6900 Georgia Ave NW, Washington, DC 20307 USA. RI Andrade, Hugo/M-6631-2013 OI Andrade, Hugo/0000-0001-6781-6125 NR 19 TC 6 Z9 6 U1 0 U2 0 PU AUSTRALIAN SOC ANAESTHETISTS PI EDGECLIFF PA P O BOX 600, EDGECLIFF, NSW 2021, AUSTRALIA SN 0310-057X J9 ANAESTH INTENS CARE JI Anaesth. Intensive Care PD FEB PY 2006 VL 34 IS 1 BP 21 EP 24 PG 4 WC Anesthesiology; Critical Care Medicine SC Anesthesiology; General & Internal Medicine GA 024PW UT WOS:000236209500004 PM 16494144 ER PT J AU Mita, MM Ochoa, L Rowinsky, EK Kuhn, J Schwartz, G Hammond, LA Patnaik, A Yeh, IT Izbicka, E Berg, K Tolcher, AW AF Mita, MM Ochoa, L Rowinsky, EK Kuhn, J Schwartz, G Hammond, LA Patnaik, A Yeh, IT Izbicka, E Berg, K Tolcher, AW TI A phase I, pharmacokinetic and biologic correlative study of oblimersen sodium (Genasense (TM), G3139) and irinotecan in patients with metastatic colorectal cancer SO ANNALS OF ONCOLOGY LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 12-15, 2001 CL SAN FRANCISCO, CA SP Amer Soc Clin Oncol DE antisense oligonucleotide; Bcl-2; irinotecan; oblimersen; phase I pharmacokinetics ID BCL-2 ANTISENSE OLIGONUCLEOTIDE; NON-HODGKINS-LYMPHOMA; LUNG-CANCER; INDUCED APOPTOSIS; PROSTATE-CANCER; BREAST-CANCER; SOLID TUMORS; SCID MICE; EXPRESSION; THERAPY AB Purpose: To assess the feasibility and antitumor activity of oblimersen sodium, an antisense oligonucleotide directed to the Bcl-2 mRNA, combined with irinotecan in patients with advanced colorectal carcinoma, characterize the pharmacokinetic behavior of both oblimersen sodium and irinotecan, and examine Bcl-2 protein inhibition in peripheral blood mononuclear cells (PBMC). Patients and methods: Patients were treated with escalating doses of oblimersen sodium administered by continuous intravenous infusion (CIVI) days 1-8, and irinotecan administered intravenously on day 6 once every 3 weeks. Results: Twenty patients received a total of 84 courses at doses ranging from 3 to 7 mg/kg/day for oblimersen sodium and from 280 to 350 mg/m(2) for irinotecan. Febrile neutropenia and diarrhea limited escalation of oblimersen sodium and irinotecan to 5 mg/kg/day and 350 mg/m(2), respectively. Other toxicities included nausea, vomiting, fever and fatigue. Steady-state plasma concentrations were achieved within 48 h of beginning oblimersen sodium treatment and the agent was undetectable 24 h after the discontinuation of the infusion. Reduction in levels of Bcl-2 protein in PBMC was documented following treatment with oblimersen sodium. One patient experienced a partial response and 10 additional patients had stable disease lasting 2.5-10 months. Conclusions: The combination is well tolerated at the recommended phase II oblimersen sodium dose of 7 mg/kg/day CIVI days 1-8 with irinotecan 280 mg/m(2) intravenously on day 6 every 3 weeks. C1 Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78284 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA. RP Tolcher, AW (reprint author), Canc Therapy & Res Ctr S Texas, Inst Drug Dev, 7979 Wurzbach Rd,Suite Z414, San Antonio, TX 78229 USA. EM atolcher@idd.org FU NCI NIH HHS [P30-CA54174, UO1-CA69853] NR 37 TC 34 Z9 35 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD FEB PY 2006 VL 17 IS 2 BP 313 EP 321 DI 10.1093/annonc/mdj067 PG 9 WC Oncology SC Oncology GA 007JN UT WOS:000234965100022 PM 16322117 ER PT J AU Ellsworth, R Ellsworth, DL Love, B Hooke, JA Shriver, CD AF Ellsworth, R Ellsworth, DL Love, B Hooke, JA Shriver, CD TI Genomic alterations in primary breast carcinomas do not predict axillary lymph node metastasis SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 59th Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 23-26, 2006 CL San Diego, CA SP Soc Surg Oncol C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2006 VL 13 IS 2 SU S BP 35 EP 35 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 009BG UT WOS:000235085500104 ER PT J AU Mittendorf, EA Storrer, CE Flora, MN Shriver, CD Peoples, GE Ponniah, S AF Mittendorf, EA Storrer, CE Flora, MN Shriver, CD Peoples, GE Ponniah, S TI The development of a novel method to identify immunogenic peptides for use in cancer vaccines SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 59th Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 23-26, 2006 CL San Diego, CA SP Soc Surg Oncol C1 Uniformed Serv Univ Hlth Sci, Clin Breast Care Project, Immunol & Res Ctr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Biomed Instrumentat Ctr, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2006 VL 13 IS 2 SU S BP 63 EP 63 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 009BG UT WOS:000235085500203 ER PT J AU Hamsher, C Smith, A Dehqanzada, ZA Khoo, S Shriver, CD Ponniah, S Peoples, GE Moroni, M AF Hamsher, C Smith, A Dehqanzada, ZA Khoo, S Shriver, CD Ponniah, S Peoples, GE Moroni, M TI Pattern of serum immunoreactivity against breast cancer cell lysates may predict severity of disease in breast cancer patients SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 59th Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 23-26, 2006 CL San Diego, CA SP Soc Surg Oncol C1 Uniformed Serv Univ Hlth Sci, Clin Breast Care Project, Immunol & Res Ctr, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2006 VL 13 IS 2 SU S BP 65 EP 65 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 009BG UT WOS:000235085500210 ER PT J AU Gallo, DR Lett, ED Conner, WC AF Gallo, DR Lett, ED Conner, WC TI Surgical repair of a chronic traumatic sternal fracture SO ANNALS OF THORACIC SURGERY LA English DT Article ID FIXATION AB Chronic sternal fracture nonunion is usually reported after median sternotomy, but rarely after blunt chest trauma. Most traumatic fractures of the sternum are managed nonoperatively if they are asymptomatic and nondisplaced. Acute surgical therapy is indicated for debilitating chest pain usually associated with fracture displacement. We report a case of debilitating chest pain associated with a chronic sternal fracture. Our surgical technique is discussed and the literature is reviewed. C1 Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Conner, WC (reprint author), Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. EM william.conner@amedd.army.mil NR 7 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD FEB PY 2006 VL 81 IS 2 BP 726 EP 728 DI 10.1016/j.athoracsur.2004.11.057 PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA 009VV UT WOS:000235142400055 PM 16427887 ER PT J AU Bolken, TC Laquerre, S Zhang, YM Bailey, TR Pevear, DC Kickner, SS Sperzel, LE Jones, KF Warren, TK Lund, SA Kirkwood-Watts, DL King, DS Shurtleff, AC Guttieri, MC Deng, YJ Bleam, M Hruby, DE AF Bolken, TC Laquerre, S Zhang, YM Bailey, TR Pevear, DC Kickner, SS Sperzel, LE Jones, KF Warren, TK Lund, SA Kirkwood-Watts, DL King, DS Shurtleff, AC Guttieri, MC Deng, YJ Bleam, M Hruby, DE TI Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses SO ANTIVIRAL RESEARCH LA English DT Article DE arenavirus; antiviral; tacaribe; Junin; hemorrhagic fever ID CHORIOMENINGITIS VIRUS GLYCOPROTEIN; SUBTILASE SKI-1/S1P; LASSA-VIRUS; FUSION; INFECTION; DOMAIN; MECHANISMS; ECTODOMAIN; PHYLOGENY; DISEASE AB Category A arenaviruses as defined by the National Institute of Allergy and Infectious Diseases (NIAID) are human pathogens that could be weaponized by bioterrorists. Many of these deadly viruses require biosafety level-4 (BSL-4) containment for all laboratory work, which limits traditional laboratory high-throughput screening (HTS) for identification of small molecule inhibitors. For those reasons, a related BSL-2 New World arenavirus, Tacaribe virus, 67-78% identical to Junin virus at the amino acid level, was used in a HTS campaign where approximately 400,000 small molecule compounds were screened in a Tacaribe virus-induced cytopathic effect (CPE) assay. Compounds identified in this screen showed antiviral activity and specificity against not only Tacaribe virus, but also the Category A New World arenaviruses (Junin, Machupo, and Guanarito). Drug resistant variants were isolated, suggesting that these compounds act through inhibition of a viral protein, the viral glycoprotein (GP2), and not through cellular toxicity mechanisms. A lead compound, ST-294, has been chosen for drug development. This potent and selective compound, with good bioavailability, demonstrated protective anti-viral efficacy in a Tacaribe mouse challenge model. This series of compounds represent a new class of inhibitors that may warrant further development for potential inclusion in a strategic stockpile. (c) 2005 Elsevier B.V. All rights reserved. C1 SIGA Technol Inc, Corvallis, OR 97333 USA. ViroPharma Inc, Exton, PA 19341 USA. USA, Med Res Inst Infect Dis, Dept Mol Virol, Frederick, MD 21702 USA. RP Hruby, DE (reprint author), SIGA Technol Inc, 4575 SW Res Way, Corvallis, OR 97333 USA. EM dhruby@sgph.com FU NIAID NIH HHS [7 R43 AI056525-02]; PHS HHS [5R44 A1056525-04] NR 33 TC 59 Z9 60 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD FEB PY 2006 VL 69 IS 2 BP 86 EP 97 DI 10.1016/j.antiviral.2005.10.008 PG 12 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 013OH UT WOS:000235418100005 PM 16343651 ER PT J AU Carrieri, AH Roese, ES AF Carrieri, AH Roese, ES TI Surface contamination detection by means of near-infrared stimulation of thermal luminescence SO APPLIED OPTICS LA English DT Article AB A method for remotely detecting liquid chemical contamination on terrestrial surfaces is presented. Concurrent to irradiation by an absorbing near-infrared beam, the subject soil medium liberates radiance called thermal luminescence (TL) comprising mddle-infrared energies (V-mir) that is scanned interferometrically in beam duration tau. Cyclic states of absorption and emission by the contaminant surrogate are rendered from a sequential differential-spectrum measurement [delta S(v(mir), tau)] of the scanned TL. Detection of chemical warfare agent simulant wetting soil is performed in this manner, for example, through pattern recognition of its unique, thermally dynamic, molecular vibration resonance bands on display in the delta S(v(mir), tau) metric. (c) 2006 Optical Society of America. C1 USA, RDECOM, ECBC, ATTN,AMSRD,ECB,RT,DL, Aberdeen Proving Ground, MD 21010 USA. RP Carrieri, AH (reprint author), USA, RDECOM, ECBC, ATTN,AMSRD,ECB,RT,DL, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Arthur.Carrieri@us.army.mil; Erik.Roese@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2006 VL 45 IS 4 BP 736 EP 743 DI 10.1364/AO.45.000736 PG 8 WC Optics SC Optics GA 008XR UT WOS:000235074600018 PM 16485685 ER PT J AU Flanigan, DF Samuels, AC Zhu, CJ D'Amico, F AF Flanigan, DF Samuels, AC Zhu, CJ D'Amico, F TI Noise, clutter, and determinism in infrared spectral signatures under varying meteorological conditions SO APPLIED OPTICS LA English DT Article ID PLUMES AB Infrared remote detection of chemical and biological agents in a complex environment depends on the ability to recognize threat signatures and differentiate them from the signatures of innocuous materials. In this paper, we addressed the methods of producing the constraint spectra needed to ensure reliable operation in a meteorologically changing environment. We collected arrays of background spectra of ground, woods, and low-angle sky on an irregular basis over a period of a year. Based on the hypothesis that the concentration fluctuations of species in the sensor's field of view can be exploited to form signatures, the standard deviations of the array (the result is characteristic of all fluctuations) and the difference array (the result is characteristic of sensor fluctuations) were computed. Subtracting these two spectra and filtering the result produced a spectrum, which is a measure of the IR fluctuations in the scene. The resulting set of scene spectra were processed into aberrant noise, and deterministic groups by numerical filtering and statistical methods. (c) 2006 Optical Society of America. C1 SymSpec, Baltimore, MD 21209 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. Battelle Inc, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. RP Flanigan, DF (reprint author), SymSpec, 2418 Briarwood Rd, Baltimore, MD 21209 USA. EM dfflanig@worldnet.att.net NR 15 TC 0 Z9 0 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2006 VL 45 IS 4 BP 799 EP 808 DI 10.1364/AO.45.000799 PG 10 WC Optics SC Optics GA 008XR UT WOS:000235074600025 PM 16485692 ER PT J AU Sherer, Y Tsokos, GC AF Sherer, Y Tsokos, GC TI Clinical Immunology Society spring school on Systemic Autoimmune Diseases, Santa Fe, New Mexico, USA, March 26, 2005 SO AUTOIMMUNITY REVIEWS LA English DT Editorial Material C1 Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Tel Aviv Univ, Sackler Fac Med, Sheba Med Ctr Tel Hashomer, Ctr Autoimmune Dis, IL-69978 Tel Aviv, Israel. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Tel Aviv Univ, Sackler Fac Med, Sheba Med Ctr Tel Hashomer, Dept Med B, IL-69978 Tel Aviv, Israel. RP Sherer, Y (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. EM gtsokos@usa.net NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9972 J9 AUTOIMMUN REV JI Autoimmun. Rev. PD FEB PY 2006 VL 5 IS 2 BP 85 EP 85 DI 10.1016/j.autrev.2005.08.002 PG 1 WC Immunology SC Immunology GA 012OV UT WOS:000235349400001 ER PT J AU Fleming, SD Tsokos, GC AF Fleming, SD Tsokos, GC TI Complement, natural antibodies, autoantibodies and tissue injury SO AUTOIMMUNITY REVIEWS LA English DT Article; Proceedings Paper CT CIS Spring School on Systemic Autoimmune Diseases CY MAR 02-06, 2005 CL Santa Fe, NM SP Clin Immunol Soc DE natural antibodies; tissue injury; autoantibodies; complement activation ID ISCHEMIA/REPERFUSION-INDUCED INJURY; T-DEPENDENT ANTIGEN; MICE DEFICIENT; CELL; REPERFUSION; RECEPTOR-2; ACTIVATION; GENE; CR-2; EXPRESSION AB Activation of the classical complement pathway represents an effector mechanism of intestinal ischemia/reperfusion injury. Mice deficient in complement receptors I and 2 fail to produce a component of the natural antibody repertoire that binds to ischemia-conditioned tissues and activate complement. In contrast, mice prone to autoimmunity display accelerated and enhanced tissue injury that results from the binding of autoantibodies to injured tissues. Our experiments demonstrate that naturally occurring antibodies and autoantibodies mediate tissue injury only after an organ has been subjected to a stressor such as ischemia. Published by Elsevier B.V. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Room 1A32,Bldg 503,Robert Grant Ave, Silver Spring, MD 20910 USA. EM gtsokos@usuhs.mil FU NIAID NIH HHS [R01 AI061691] NR 24 TC 53 Z9 54 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9972 J9 AUTOIMMUN REV JI Autoimmun. Rev. PD FEB PY 2006 VL 5 IS 2 BP 89 EP 92 DI 10.1016/j.autrev.2005.09.006 PG 4 WC Immunology SC Immunology GA 012OV UT WOS:000235349400003 PM 16431334 ER PT J AU Kandelaars, KJ Fletcher, A Eitzen, GE Roach, GD Dawson, D AF Kandelaars, KJ Fletcher, A Eitzen, GE Roach, GD Dawson, D TI Layover sleep prediction for cockpit crews during transmeridian flight patterns SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE sleep prediction; transmeridian flight; social impact; biological impact ID LONG-DISTANCE FLIGHTS; 2-DAY LAYOVER; WAKE PATTERNS; PERFORMANCE; RESTRICTION; FATIGUE; AIRCREW AB Introduction: Current models of fatigue and alertness use a combination of biological (circadian) and homeostatic factors to predict sleep and wake. Such models do not include social factors in their calculations. The aim of our analysis was to compare the relative contributions of social and biological factors in models designed to predict the total sleep time (TST) during layover periods between transmeridian flights. Method: The study actigraphically collected sleep information from 86 cockpit crew (mean age 46.7 yr, SD 4.3 yr) during round-trip patterns from Australia to Los Angeles (n = 15), Europe (n = 42), New York (n = 10), and Hong Kong (n = 19). Linear regression models were constructed to predict TST using data from airline schedules. This schedule information included layover length, flight duration, the number of night hours at the destination (social hours), the number of night hours in Australian Eastern Standard time (biological hours), and time zone displacement. These models were then validated using independent data. Results. Analysis indicated that the schedule data was highly correlated. Linear regression analyses indicated that social night hours account for more variance than biological night hours (r = 0.8 vs. 0.7). Additionally, the layover length achieved a correlation coefficient of 0.9. These results were strengthened when the model parameters were applied to the cross-validation dataset. Discussion: Social night hours significantly influence sleep during international layovers and may be a better predictor than biological night hours. More research must be carried out to determine the validity of these findings in a larger, randomly collected flight sample. C1 Univ S Australia, Ctr Sleep Res, Adelaide, SA 5000, Australia. Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci & Psychiat, Silver Spring, MD USA. CSIRO Math & Informat Sci, Clayton, Vic, Australia. RP Kandelaars, KJ (reprint author), Univ S Australia, Ctr Sleep Res, Level 7,Playford Bldg,City E Campus,Frome Rd, Adelaide, SA 5000, Australia. EM Kaiie.Kandelaars@unisa.edu.au RI Roach, Gregory/E-6624-2010; OI Roach, Greg/0000-0003-4005-1243 NR 19 TC 5 Z9 5 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2006 VL 77 IS 2 BP 145 EP 150 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 009JA UT WOS:000235106700009 PM 16491583 ER PT J AU Bruno, FF Fossey, SA Nagarajan, S Nagarajan, R Kumar, J Samuelson, LA AF Bruno, FF Fossey, SA Nagarajan, S Nagarajan, R Kumar, J Samuelson, LA TI Biomimetic synthesis of water-soluble conducting copolymers/homopolymers of pyrrole and 3,4-ethylenedioxythiophene SO BIOMACROMOLECULES LA English DT Article ID POLYMERIZATION; PEROXIDASE; POLYANILINE; HEMATIN; MEDIA AB A novel biomimetic route for the synthesis of electrically conducting homopolymers/copolymers of pyrrole and 3,4-ethylenedioxythiophene (EDOT) in the presence of a polyelectrolyte, such as polystyrene sulfonate (SPS), is presented. A poly(ethylene glycol)-modified hematin (PEG-hematin) was used to catalyze the homopolymerization of pyrrole and EDOT as well as copolymerization of EDOT and pyrrole in the presence of SPS to yield homopolymers of polypyrrole/SPS and PEDOT/SPS as well as a polypyrrole-co-poly(3,4-ethylenedioxythiophene)/ SPS complex. Spectroscopic characterization [UV-visible, Fourier transform infrared (FTIR), and X-ray photoelectron spectroscopy (XPS)], thermal analysis, (TGA), and electrical conductivity studies for these complexes indicated the presence of a stable and electrically conductive form of these polymers. Furthermore, the presence of SPS that serves as a charge-compensating dopant in this complex provides a unique combination of properties such as processability and water solubility. C1 USA, RDECOM, Nanotechnol Team, Natick Soldier Ctr, Natick, MA 01760 USA. Univ Massachusetts, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. RP Bruno, FF (reprint author), USA, RDECOM, Nanotechnol Team, Natick Soldier Ctr, Natick, MA 01760 USA. NR 20 TC 33 Z9 33 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD FEB PY 2006 VL 7 IS 2 BP 586 EP 589 DI 10.1021/bm0506501 PG 4 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 015FZ UT WOS:000235538600027 PM 16471934 ER PT J AU Lee, MS Olson, MA AF Lee, MS Olson, MA TI Calculation of absolute protein-ligand binding affinity using path and endpoint approaches SO BIOPHYSICAL JOURNAL LA English DT Article ID EXPLICIT/IMPLICIT SOLVENT METHOD; MOLECULAR-DYNAMICS SIMULATIONS; FREE-ENERGY DIFFERENCES; CONTINUUM SOLVENT; HARMONIC-ANALYSIS; LARGE SYSTEMS; COMPLEX; MODELS; COMPUTATION; AVIDIN AB A comparative analysis is provided of rigorous and approximate methods for calculating absolute binding affinities of two protein-ligand complexes: the FKBP protein bound with small molecules 4-hydroxy-2-butanone and FK506. Our rigorous approach is an umbrella sampling technique where a potential of mean force is determined by pulling the ligand out of the protein active site over several simulation windows. The results of this approach agree well with experimentally observed binding affinities. Also assessed is a commonly used approximate endpoint approach, which separately estimates enthalpy, solvation free energy, and entropy. We show that this endpoint approach has numerous variations, all of which are prone to critical shortcomings. For example, conventional harmonic and quasiharmonic entropy estimation procedures produce disparate results for the relatively simple protein-ligand systems studied in this work. C1 USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. EM michael.lee@amedd.army.mil NR 56 TC 103 Z9 104 U1 5 U2 24 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD FEB PY 2006 VL 90 IS 3 BP 864 EP 877 DI 10.1529/biophysj.105.071589 PG 14 WC Biophysics SC Biophysics GA 002BK UT WOS:000234586200016 PM 16284269 ER PT J AU McLeod, DG Iversen, P See, WA Morris, T Armstrong, J Wirth, MP AF McLeod, DG Iversen, P See, WA Morris, T Armstrong, J Wirth, MP CA Casodex Early Prostate Canc Tr Grp TI Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer SO BJU INTERNATIONAL LA English DT Article DE adjuvant; antiandrogen; bicalutamide; localized; locally advanced; prostate cancer ID ANDROGEN-DEPRIVATION THERAPY; RANDOMIZED CONTROLLED-TRIAL; PREVENT BONE LOSS; RADICAL PROSTATECTOMY; PELVIC LYMPHADENECTOMY; INDUCED GYNECOMASTIA; RADIATION-THERAPY; FOLLOW-UP; ADJUVANT; RADIOTHERAPY AB OBJECTIVE To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or locally advanced, nonmetastatic prostate cancer. PATIENTS AND METHODS The EPC programme comprises three randomized, double-blind, placebo-controlled trials designed for combined analysis. Following standard care, 8113 men with localized (T1-2, NO/Nx) or locally advanced (T3-4, any N; or any T, N+) prostate cancer (all MO) received oral bicalutamide 150 mg once daily or oral placebo. The primary endpoints were progression-free survival (PFS) and overall survival. RESULTS The large EPC trial programme is defining men who benefit or do not from early or adjuvant antiandrogen therapy. At a median follow-up of 7.4 years, in localized disease there is no benefit to PFS by adding bicalutamide to standard care, and there is a trend (hazard ratio, HR, 1.16; 95% confidence intervals, CI, 0.99-1.37; P = 0.07) towards decreased survival in patients otherwise undergoing watchful waiting. However, in locally advanced disease, bicalutamide significantly improved PFS irrespective of standard care. Bicalutamide significantly improved overall survival in patients receiving radiotherapy (HR 0.65; 95% CI 0.44-0.95; P = 0.03); this was driven by a lower risk of prostate cancer-related deaths. Bicalutamide produced a trend towards improved overall survival in patients with locally advanced disease otherwise undergoing watchful waiting (HR 0.81; 95% CI 0.66-1.01; P = 0.06). No survival difference was evident in the prostatectomy subgroup. CONCLUSIONS This ongoing programme is clarifying the role of early or adjuvant antiandrogen therapy in prostate cancer. Patients with localized disease do not appear to derive clinical benefit from added bicalutamide. However, adding bicalutamide 150 mg to standard care provides significant clinical benefits in patients with locally advanced prostate cancer, irrespective of primary therapy. C1 Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. Rigshosp, Dept Urol, DK-2100 Copenhagen, Denmark. Med Coll Wisconsin, Milwaukee, WI 53226 USA. AstraZeneca, Macclesfield, Cheshire, England. Tech Univ Dresden, D-8027 Dresden, Germany. RP McLeod, DG (reprint author), Walter Reed Army Med Ctr, Urol Serv, Bldg 2, Washington, DC 20307 USA. EM david.mcleod@na.amedd.army.mil NR 21 TC 176 Z9 184 U1 1 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1464-4096 J9 BJU INT JI BJU Int. PD FEB PY 2006 VL 97 IS 2 BP 247 EP 254 DI 10.1111/j.1464-410X.2005.06051.x PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 003EM UT WOS:000234664400010 PM 16430622 ER PT J AU Montain, SJ Cheuvront, SN Sawka, MN AF Montain, SJ Cheuvront, SN Sawka, MN TI Exercise associated hyponatraemia: quantitative analysis to understand the aetiology SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID PROLONGED EXERCISE; FLUID REPLACEMENT; WATER-INTOXICATION; ELECTROLYTE STATUS; SWEAT COMPOSITION; MARATHON RUNNERS; SODIUM; HEAT; HUMANS; CARE AB Background: The development of symptomatic hyponatraemia consequent on participation in marathon and ultraendurance races has led to questions about its aetiology and prevention. Objectives: To evaluate: ( a) the assertion that sweat sodium losses cannot contribute to the development of hyponatraemia during endurance exercise; ( b) the adequacy of fluid replacement recommendations issued by the International Marathon Medical Directors Association ( IMMDA) for races of 42 km or longer; ( c) the effectiveness of commercial sports drinks, compared with water, for attenuating plasma sodium reductions. Methods: A mathematical model was used to predict the effects of different drinking behaviours on hydration status and plasma sodium concentration when body mass, body composition, running speed, weather conditions, and sweat sodium concentration were systematically varied. Results: Fluid intake at rates that exceed sweating rate is predicted to be the primary cause of hyponatraemia. However, the model predicts that runners secreting relatively salty sweat can finish ultraendurance exercise both dehydrated and hyponatraemic. Electrolyte-containing beverages are predicted to delay the development of hyponatraemia. The predictions suggest that the IMMDA fluid intake recommendations adequately sustain hydration over the 42 km distance if qualifiers - for example, running pace, body size - are followed. Conclusions: Actions to prevent hyponatraemia should focus on minimising overdrinking relative to sweating rate and attenuating salt depletion in those who excrete salty sweat. This simulation demonstrates the complexity of defining fluid and electrolyte consumption rates during athletic competition. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. Univ Cape Town, ZA-7925 Cape Town, South Africa. Gatorade Sports Sci Inst, Chicago, IL USA. Univ Connecticut, Human Performance Lab, Storrs, CT 06269 USA. RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. EM scott.montain@us.army.mil NR 38 TC 71 Z9 72 U1 1 U2 11 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD FEB PY 2006 VL 40 IS 2 BP 98 EP 106 DI 10.1136/bjsm.2005.018481 PG 9 WC Sport Sciences SC Sport Sciences GA 005NP UT WOS:000234831400005 PM 16431994 ER PT J AU Guo, JX Wu, JJQ Wright, JB Lushington, GH AF Guo, JX Wu, JJQ Wright, JB Lushington, GH TI Mechanistic insight into acetylcholinesterase inhibition and acute toxicity of organophosphorus compounds: A molecular modeling study SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; PERIPHERAL ANIONIC SITE; RAT-LIVER; INVITRO METABOLISM; ADME EVALUATION; DRUG DISCOVERY; ACTIVE-CENTER; PROTEIN; BRAIN; CHLORPYRIFOS AB Acute toxicity of organophosphorus (OP) compounds results mainly from irreversible acetylcholinesterase (AChE) inhibition; however OP toxicity frequently hinges on prior biotransformations that produce toxic metabolites. To account for both precursor metabolic effects and primary AChE inhibition, we included absorption, distribution, metabolism, excretion (ADME) effects, ligand binding, and reactive AChE phosphorylation and aging in a detailed but computationally expedient phenomenological toxicity model. Ligand negative accessible surface area (NASA) was used as a generic ADME descriptor, while relevant metabolic, phosphorylation, and aging reactions were assessed via quantum chemical enthalpy calculations, and the binding affinity of the Michaelis complex was quantified via Comparative Molecular Field Analysis (CoMFA). The resulting model correlates very well (R-2 = 0.90) with experimental acute toxicity measurements and provides useful mechanistic insight into the underlying toxicity. Model predictivity was validated by leave-one-out cross-validation (Q(2) = 0.82). The Michaelis binding affinity descriptor has the largest weight in our model, but subsequent covalent inhibition and prior ADME effects also exhibit significant effects. C1 Univ Kansas, Mol Graphics & Modeling Lab, Lawrence, KS 66045 USA. VM Discovery Inc, Fremont, CA 94538 USA. USA, RDECOM Natick Soldier Ctr, Natick, MA 01760 USA. RP Lushington, GH (reprint author), Univ Kansas, Mol Graphics & Modeling Lab, Lawrence, KS 66045 USA. EM glushington@ku.edu NR 53 TC 27 Z9 28 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD FEB PY 2006 VL 19 IS 2 BP 209 EP 216 DI 10.1021/tx050090r PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 015XM UT WOS:000235584800003 PM 16485896 ER PT J AU Wani, AH O'Neal, BR Gilbert, DM Gent, DB Davis, JEL AF Wani, AH O'Neal, BR Gilbert, DM Gent, DB Davis, JEL TI Electrolytic transformation of ordinance related compounds (ORCs) in groundwater: Laboratory mass balance studies SO CHEMOSPHERE LA English DT Article DE electrolysis; explosives; RDX; TNT; e(-) barrier; electrolytic treatment ID ELECTROCHEMICAL REDUCTION; ALKALINE-HYDROLYSIS; ANAEROBIC SLUDGE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; DEGRADATION; RDX; 2,4-DINITROTOLUENE; BIODEGRADATION; OXIDATION; INSIGHTS AB Electrolytic reactive barriers (e(-) barriers) consist of closely spaced permeable electrodes installed across a ground- water contaminant plume in a permeable reactive barrier format. Application Of sufficient potential to the electrodes results in sequential oxidation and reduction of the target contaminant. The objective of this study was to quantify the mass distribution of compounds produced during sequential electrolytic oxidation and reduction of ordinance related compounds (ORCs) in a laboratory analog to an e-barrier. In this study, a series of column tests were conducted using RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and TNT (2,4,6-trinitrotoluene) as representative ORCs. The experimental setup consisted of a plexiglass column packed with quartz-feldspar sand to simulate aquifer conditions. A single set of porous electrodes consisting of expanded titanium-mixed metal oxide mesh was placed at the midpoint of the sand column as a one-dimensional analog to an e(-) barrier. Constant current of 20 mA (variable voltage) was applied to the electrode set. Initial studies involved quantification of reaction products using unlabeled RDX and TNT. Approximately 70% of the influent concentration was transformed, in one pass, through sequential oxidation-reduction for both contaminants. Following the unlabeled studies, C-14 labeled RDX and TNT were introduced to determine the mass balance. An activity balance of up to 96% was achieved for both C-14-RDX and C-14-TNT. For both contaminants, approximately 21% of the influent activity was mineralized to (CO2)-C-14. The proportion of the initial activity in the dissolved fraction was different for the two test contaminants. Approximately 30% of the initial C-14-RDX was recovered as unreacted in the dissolved phase. The balance of the C-14-RDX was recovered as non-volatile, non-nitroso transformation products. None of the C-14-RDX was sorbed to the column sand packing. For C-14-TNT approximately 51% of the initial activity was recovered in the dissolved phase, the majority was unreacted TNT. The balance of the C-14-TNT was either sorbed to the sand packing (approximately 24%) or dissolved/mineralized as unidentified ring cleavage products (similar to 4%). (c) 2005 Elsevier Ltd. All rights reserved. C1 Appl Res Associates Inc, Vicksburg, MS 39180 USA. Analyt Serv Inc, Vicksburg, MS 39180 USA. Colorado State Univ, Dept Civil Engn, Ft Collins, CO 80523 USA. USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Wani, AH (reprint author), Appl Res Associates Inc, 119 Monument Pl, Vicksburg, MS 39180 USA. EM altaf.h.wani@erdc.usace.army.mil NR 20 TC 9 Z9 9 U1 2 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2006 VL 62 IS 5 BP 689 EP 698 DI 10.1016/j.chemosphere.2005.06.012 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA 013UY UT WOS:000235436700001 PM 16081140 ER PT J AU Villines, TC Atwood, JE AF Villines, TC Atwood, JE TI Images in cardiology: A sparkling case of familial, cardiac-specific amyloidosis SO CLINICAL CARDIOLOGY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 USA SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD FEB PY 2006 VL 29 IS 2 BP 89 EP 89 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 008OK UT WOS:000235050100010 PM 16506646 ER PT J AU Woods, SP Rippeth, JD Conover, E Carey, CL Parsons, TD Troster, AI AF Woods, SP Rippeth, JD Conover, E Carey, CL Parsons, TD Troster, AI TI Statistical power of studies examining the cognitive effects of subthalamic nucleus deep brain stimulation in Parkinson's disease SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article ID CHRONIC BILATERAL STIMULATION; NEUROPSYCHOLOGICAL CHANGES; PSYCHOLOGICAL-RESEARCH; CONSECUTIVE SERIES; STN; PD; CONSEQUENCES; PALLIDOTOMY; JOURNALS; TESTS AB It has been argued that neuropsychological studies generally possess adequate statistical power to detect large effect sizes. However, low statistical power is problematic in neuropsychological research involving clinical populations and novel interventions for which available sample sizes are often limited. One notable example of this problem is evident in the literature regarding the cognitive sequelae of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in persons with Parkinson's disease (PD). In the current review, a post hoc estimate of the statistical power of 30 studies examining cognitive effects of STN DBS in PD revealed adequate power to detect substantial cognitive declines (i.e., very large effect sizes), but surprisingly low estimated power to detect cognitive changes associated with conventionally small, medium, and large effect sizes. Such wide spread Type II error risk in the STN DBS cognitive outcomes literature may affect the clinical decision-making process as concerns the possible risk of postsurgical cognitive morbidity, as well as conceptual inferences to be drawn regarding the role of the STN in higher-level cognitive functions. Statistical and methodological recommendations (e.g., meta-analysis) are offered to enhance the power of current and future studies examining the neuropsychological sequelae of STN DBS in PD. C1 Univ Calif San Diego, Dept Psychiat, HIV Neurobehav Res Ctr, San Diego, CA 92103 USA. Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27706 USA. Univ Calif San Diego, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA. San Diego State Univ, San Diego, CA 92182 USA. Fuller Theol Seminary, Dept Psychol, Pasadena, CA 91182 USA. Univ N Carolina, Dept Neurol, Chapel Hill, NC USA. RP Woods, SP (reprint author), Univ Calif San Diego, Dept Psychiat, HIV Neurobehav Res Ctr, 0603-H,150 W Washington St,2nd Floor, San Diego, CA 92103 USA. EM spwoods@ucsd.edu NR 62 TC 28 Z9 29 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1385-4046 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PD FEB PY 2006 VL 20 IS 1 BP 27 EP 38 DI 10.1080/13854040500203290 PG 12 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 999OL UT WOS:000234399000003 PM 16393919 ER PT J AU Kayanja, M Evans, K Milks, R Lieberman, IH AF Kayanja, Mark Evans, Korboi Milks, Ryan Lieberman, Isador H. TI The mechanics of polymethylmethacrylate augmentation SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID VIVO BIOMECHANICAL EVALUATION; VERTEBRAL COMPRESSION FRACTURES; CALCIUM-PHOSPHATE CEMENT; LUMBAR SPINE; PERCUTANEOUS VERTEBROPLASTY; HYDROXYAPATITE CEMENT; THORACIC VERTEBRAE; KYPHOPLASTY; MODEL; OSTEOPOROSIS AB Osteoporosis frequently leads to vertebral compression fractures. Percutaneous cement augmentation, one recent technique, may alter the biomechanics of the vertebral body and spinal segment. These alterations reportedly predispose the spinal segment to additional vertebral compression fractures. We investigated the changes in segment stiffness and strength after polymethylmethacrylate augmentation. Twelve thoracic segments consisting of five vertebral bodies were divided into two groups, a pure moment group (Group 1) and an eccentric compression group (Group 2). Baseline measurements of stiffness were taken on each segment followed by the creation of an initial vertebral compression fracture during which stiffness and strength were measured. After augmentation, stiffness was again measured. Finally, a second vertebral compression fracture was created measuring stiffness and strength again. Augmentation did not alter stiffness before and after augmentation in either group. Augmentation also did not result in any difference in strength measured at subsequent fracture when compared with strength measured at initial fracture in either group. The augmentation of vertebral compression fractures by kyphoplasty does not alter the stiffness or the strength of the multilevel segments and eccentric compression in contrast to pure moments leads to a lower strength during mechanical testing. C1 Cleveland Clin Fdn, Dept Orthopaed Surg A41, Cleveland Clin Spine Inst, Cleveland, OH 44195 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Cleveland Clin Fdn, Spine Res Lab W31, Cleveland, OH 44195 USA. RP Lieberman, IH (reprint author), Cleveland Clin Fdn, Dept Orthopaed Surg A41, Cleveland Clin Spine Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA. EM lieberi@ccf.org NR 38 TC 9 Z9 10 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD FEB PY 2006 IS 443 BP 124 EP 130 DI 10.1097/01.blo.0000200243.60426.57 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 119NV UT WOS:000243019900023 PM 16462435 ER PT J AU Shorr, AF Jackson, WL Kollef, MH AF Shorr, AF Jackson, WL Kollef, MH TI Fluconazole prophylaxis - Reply SO CRITICAL CARE MEDICINE LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Washington Univ, St Louis, MO USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 2006 VL 34 IS 2 BP 585 EP 586 DI 10.1097/01.CCM.0000199092.41110.06 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 008UF UT WOS:000235065500073 ER PT J AU Rhinehart, BM Murphy, ME Farley, MF Albertini, JG AF Rhinehart, BM Murphy, ME Farley, MF Albertini, JG TI Sterile versus nonsterile gloves during Mohs micrographic surgery: Infection rate is not affected SO DERMATOLOGIC SURGERY LA English DT Editorial Material AB BACKGROUND: Mohs micrographic surgery (MMS) is an outpatient procedure, which has become the treatment of choice for certain cutaneous malignancies. Although the major steps in this procedure are relatively standardized, one difference involves the use of sterile or nonsterile, clean gloves during the tumor removal phase. OBJECTIVE: This retrospective, chart review study was performed to evaluate whether infection rates are affected by the use of sterile versus nonsterile gloves in the tumor extirpation phase of MMS. METHODS: This study evaluated the surgical records of 1,810 consecutive Mohs patients, of which 1,239 Mohs patients (1,400 Mohs procedures) met inclusion criteria. Age, sex, tumor diagnosis, anatomic location, number of Mohs stages, area of defect, closure type, cartilage exposure, and sterile versus nonsterile glove use were recorded and evaluated. RESULTS: Twenty-five infections were identified. Statistically significant infection rates were discovered for patients with cartilage fenestration with secondary healing and malignant melanoma diagnosis only. There was no statistical difference in infection rates with all other measured variables to include the use of sterile or clean, nonsterile gloves. CONCLUSION: Our study lends support that clean, nonsterile gloves are safe and effective for use in the tumor extirpation phase of MMS, at a significant cost savings. C1 Skin Surg Ctr, Winston Salem, NC 27106 USA. MEDOAC, Wurzburg, Germany. Brooke Army Med Ctr, San Antonio, TX USA. RP Rhinehart, BM (reprint author), Skin Surg Ctr, 125 Sunnynoll Ct,Suite 100, Winston Salem, NC 27106 USA. EM jalbertini@skinsurgerycenter.net NR 7 TC 16 Z9 17 U1 0 U2 0 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD FEB PY 2006 VL 32 IS 2 BP 170 EP 176 DI 10.1111/j.1524-4725.2006.32031.x PG 7 WC Dermatology; Surgery SC Dermatology; Surgery GA 030LV UT WOS:000236637000002 ER PT J AU Friedl, KE Vigersky, RA AF Friedl, Karl E. Vigersky, Robert A. TI Biomedically enabled soldiers: Super-resilient, not superhuman SO DIABETES TECHNOLOGY & THERAPEUTICS LA English DT Article ID HYPOGLYCEMIA C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Friedl, KE (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM karl.friedl@us.army.mil OI Friedl, Karl/0000-0002-3134-8427 NR 8 TC 0 Z9 0 U1 2 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1520-9156 J9 DIABETES TECHNOL THE JI Diabetes Technol. Ther. PD FEB PY 2006 VL 8 IS 1 BP 123 EP 125 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 110TY UT WOS:000242405200015 PM 16472059 ER PT J AU Gorbunov, NV Asher, LV Ayyagari, V Atkins, JL AF Gorbunov, NV Asher, LV Ayyagari, V Atkins, JL TI Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma SO EXPERIMENTAL AND MOLECULAR PATHOLOGY LA English DT Article DE lung trauma; spatial interaction; hemorrhage; inflammation; iron; adhesion molecules; heme oxygenase ID HEME OXYGENASE-1; NITRIC-OXIDE; TYROSINE NITRATION; OXIDATIVE STRESS; INJURY; PULMONARY; MYELOPEROXIDASE; HEMOGLOBIN; RESPONSES; PATHWAY AB To monitor cascade of events following alveolar extravasation of blood due to exposure to shock wave (SW), we conducted spatiotemporal assessment of myeloperoxidase (MPO), heme oxygenase 1 (HO-1), Cu,Zn superoxide dismutase (SOD-1), transferrin (TRF), 3-nitrotyrosine (3NTyr), alveolar endothelial cadherin (VE-CDH), and the CD11b adhesion molecules on leukocytes using electron microscopy, electron paramagnetic resonance spectroscopy, irninunofluorescence imaging, and immunoblotting. Accumulation of HO-1, MPO, 3NTyr, and SOD-I in HIL at the first 12 h was associated with transmigration of inflammatory leucocytes (ILK) into hemorrhagic lesions (HLs). Biodegradation of extravasated hemoglobin (exvHb) and deposition of iron in alveoli occurred at 3-56 h post-exposure and was preceded by LKC degranulation and accumulation of MPO, HO-1, and SOD-I in HLs. These alterations were accompanied by appearance of heme and non-heme iron complexes in HLs. A significant increase in TRIF-bound [Fe3+] (i.e., 14.6 +/- 5.3 mu M vs. 4.8 +/- 2.1 mu M immediately after exposure) and non-TRF complexes of [Fe3+] (i.e., 4.5 +/- 1.8 mu M vs. < 0.3 IN immediately after exposure) occurred at 24 It post-exposure. Transmigrations of ILK, nitroxidative stress, and iron deposition in endothelial and epithelial cells were accompanied by destruction of endothelial integrity at 3 h post-exposure, and alveolar capillary network and necrotic changes in the pulmonary epithelial cells at 24-56 h post-exposure. (c) 2005 Elsevier Inc. All rights reserved. C1 Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Gorbunov, NV (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. EM nikolai.gorbounov@na.amedd.army.mil RI Atkins, James/B-3577-2011 NR 35 TC 17 Z9 18 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4800 J9 EXP MOL PATHOL JI Exp. Mol. Pathol. PD FEB PY 2006 VL 80 IS 1 BP 11 EP 25 DI 10.1016/j.yexmp.2005.06.007 PG 15 WC Pathology SC Pathology GA 002OG UT WOS:000234620200002 PM 16137675 ER PT J AU Khoshbakhta, M Lin, MW Berman, JB AF Khoshbakhta, M Lin, MW Berman, JB TI Analysis of moisture-induced stresses in an FRP composites reinforced masonry structure SO FINITE ELEMENTS IN ANALYSIS AND DESIGN LA English DT Article DE moisture-induced stress; FRP reinforced masonry; multi-layered penneable structure AB It has been shown in many studies that fiber reinforced polymer (FRP) composite laminates can be used to effectively strengthen structures constructed by unreinforced masonry units. For practical application of this reinforcement method, the long-term interface bonding degradation due to moisture and temperature environmental effects needs to be addressed further. In this study, a finite-element modeling procedure for analyzing moisture-induced stresses in a multi-layered structure constructed with distinct permeable materials was developed. The modeling procedure was used to analyze moisture-induced stresses in a concrete block reinforced with a unidirectional glass-epoxy FRP composite laminate partially covering one lateral surface. The nonlinear humidity transport properties of both the concrete and FRP materials were taken into account in the analysis, and the convergence issue of the interfacial shear stress components associated with the free edge effect was addressed by the use of the submodeling, technique. It was demonstrated that the moisture-induced stresses at the FRP-concrete interface critical to structural integrity could be determined for any time instant. The results showed that the interfacial stresses increased with the increase of the humidity diffusion time and monotonically approached the stress level at the steady-state condition of the humidity diffusion. It was also shown that the analysis by assuming constant humidity transport properties resulted in a significant underestimation on the maximum interfacial stresses. The current finite-element analysis procedure provides a general method for determining moisture-induced stresses in a multi-layered permeable structure. It can be used to aid with the design of FRP-masonry structures or other similar structures for minimizing interfacial stresses induced due to the mismatch of moisture swelling properties of the constituent materials. (c) 2005 Elsevier B.V. All rights reserved. C1 Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Lin, MW (reprint author), Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. EM lin@mae.uah.edu NR 11 TC 8 Z9 9 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-874X J9 FINITE ELEM ANAL DES JI Finite Elem. Anal. Des. PD FEB PY 2006 VL 42 IS 5 BP 414 EP 429 DI 10.1016/j.finel.2004.12.013 PG 16 WC Mathematics, Applied; Mechanics SC Mathematics; Mechanics GA 016CM UT WOS:000235598300004 ER PT J AU Chernofsky, MR Felix, JC Muderspach, LI Morrow, CP Ye, W Groshen, SG Roman, LD AF Chernofsky, MR Felix, JC Muderspach, LI Morrow, CP Ye, W Groshen, SG Roman, LD TI Influence of quantity of lymph vascular space invasion on time to recurrence in women with early-stage squamous cancer of the cervix SO GYNECOLOGIC ONCOLOGY LA English DT Article DE LVSI; early-stage squamous cervical cancer; recurrence ID CHI-SQUARE STATISTICS; RADICAL HYSTERECTOMY; PROGNOSTIC-FACTORS; RADIATION-THERAPY; CELL CARCINOMA; RISK GROUPS; IB; IDENTIFICATION; METASTASES; SURVIVAL AB Objective. To determine if the quantity of lymph vascular space invasion (LVSI) correlates with time to recurrence in women with early-stage squamous carcinoma of the cervix. Methods. 101 consecutive women with Stages IA2, IB, and IIA squamous carcinoma of the cervix who had undergone radical hysterectomy between 1991 and 1997, with previously reported histopathologic quantification of LVSI by four methods, were prospectively followed. The outcome measure was time to recurrence. Univariate and stratified log-rank test analysis was performed to test the association of time to recurrence with prognostic factors. Further analysis was focused on recurrence in those patients who had negative surgical margins and whose tumors contained LVSI, incorporating the four quantification measures. Results. Nineteen (19%) women had cancer recurrence. The presence of LVSI (P = 0.05), cervical stromal invasion (P = 0.01), parametrial involvement (P < 0.001), and positive margins (P < 0.0001) were significantly related to time to recurrence on univariate analysis. In patients whose tumors had negative surgical margins and contained LVS1 (65%), percentage of all sections with LVSI > 29% and total number of foci with LVSI > 5 were significantly related to time to recurrence (P = 0.006). When stratifying for cervical stromal invasion, lymph node status, and parametrial involvement in this group, percentage of all sections with LVSl > 29% and total number of foci with LVSI > 5 were significantly related to time to recurrence (P = 0.05). Conclusion. The quantity of LVSI, as defined by the percentage of all sections with LVSI and total number of foci with LVSI, is an independent prognostic factor for time to recurrence in women with early-stage squamous carcinoma of the cervix. Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Univ So Calif, Dept Pathol, Los Angeles, CA 90033 USA. Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA. Univ So Calif, Dept Prevent Med, Los Angeles, CA 90033 USA. RP Chernofsky, MR (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW,Bldg 2 Rm 2 J-06, Washington, DC 20307 USA. EM mildred.chernofsky@na.amedd.army.mil NR 17 TC 19 Z9 21 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD FEB PY 2006 VL 100 IS 2 BP 288 EP 293 DI 10.1016/j.ygyno.2005.08.019 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 008EK UT WOS:000235022800013 PM 16182347 ER PT J AU Sun, K Ning, P Wang, C AF Sun, K Ning, P Wang, C TI Secure and resilient clock synchronization in wireless sensor networks SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE computer network security; fault tolerance; synchronization; wireless sensor networks AB Wireless sensor networks have received a lot of attention recently due to its wide applications. An accurate and synchronized clock time is crucial in many sensor network applications. Several clock synchronization schemes have been proposed for wireless sensor networks recently to address the resource constraints in such networks. However, most of these techniques assume benign environments, but cannot survive malicious attacks in hostile environments, especially when there are compromised nodes. As an exception, a recent work attempts to detect malicious attacks against clock synchronization, and aborts when an attack is detected. Though this approach can prevent incorrect clock synchronization due to attacks, it will lead to denial of clock synchronization in such situations. This paper adopts a model where all the sensor nodes synchronize their clocks to a common source, which is assumed to be well synchronized to the external clock. This paper seeks techniques to provide redundant ways for each node to synchronize its clock with the common source, so that it cantolerate partially missing or false synchronization information provided by compromised nodes. Two types of techniques are developed using this general method: level-based clock synchronization and diffusion-based clock synchronization. Targeted at static sensor networks, the level-based clock synchronization constructs a level hierarchy initially, and uses (or reuses) this level hierarchy for multiple rounds of clock synchronization. The diffusion-based clock synchronization attempts to synchronize all the clocks without relying on any structure. assumptions and, thus, can be used for dynamic sensor networks. This paper further investigates how to use multiple clock sources for both approaches to increase the resilience against compromise of source nodes. The,analysis in this paper indicates that both level-based and diffusion-based approaches can tolerate up to s colluding malicious source nodes and t colluding malicious nodes among the neighbors of each normal node, where s and t are two system parameters. This paper also presents the results of simulation studies performed to evaluate the proposed techniques. These results demonstrate that the level-based approach has less overhead and higher precision, but less coverage, than the diffusion-based approach. C1 N Carolina State Univ, Dept Comp Sci, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP N Carolina State Univ, Dept Comp Sci, Raleigh, NC 27695 USA. EM ksun3@ncsu.edu; pning@ncsu.edu; cliffwang@ncsu.edu NR 38 TC 35 Z9 40 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 EI 1558-0008 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD FEB PY 2006 VL 24 IS 2 BP 395 EP 408 DI 10.1109/JSAC.2005.861396 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 013IU UT WOS:000235403800015 ER PT J AU Zhu, L Chow, TP Jones, KA Agarwal, A AF Zhu, L Chow, TP Jones, KA Agarwal, A TI Design, fabrication, and characterization of low forward drop, low leakage, 1-kV 4H-SiC JBS rectifiers SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE 4H-SiC; AlN; anneal; fabrication; junction barrier Schottky (JBS); Schottky rectifier AB The 1-kV 4H-SiC planar junction barrier Schottky (JBS) rectifiers were designed, fabricated, and characterized. Different p+ implantation dosages and activation anneal methods were used to determine an optimum baseline process. Using the optimized process, the forward drop of our JBS rectifiers is < 1.5 V while the reverse leakage current density is < 1 X 10(-5) A/cm(-2). Blocking voltage > 1 kV was achieved using a single-zone junction termination extension termination. It was shown experimentally that 4-mu m p-type implantation window spacing gives an optimum tradeoff between forward drop voltage and leakage current density for these rectifiers, yielding a specific on-resistance of 3 m Omega center dot cm(2). C1 Rensselaer Polytech Inst, Ctr Integrated Elect & Elect Mfg, Troy, NY 12180 USA. SEDD, Army Res Lab, Adelphi, MD 20783 USA. Cree Inc, Durham, NC 27703 USA. RP Zhu, L (reprint author), Rensselaer Polytech Inst, Ctr Integrated Elect & Elect Mfg, Troy, NY 12180 USA. EM zhul3@rpi.edu NR 6 TC 29 Z9 31 U1 5 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD FEB PY 2006 VL 53 IS 2 BP 363 EP 368 DI 10.1109/TED.2005.862704 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 005UX UT WOS:000234850600024 ER PT J AU Kwon, H Nasrabadi, NM AF Kwon, H Nasrabadi, NM TI Kernel matched subspace detectors for hyperspectral target detection SO IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE LA English DT Article DE target detection; subspace detectors; matched signal detectors; kernel-based learning; hyperspectral data; spectral mixture models; nonlinear detection ID PROJECTION APPROACH; IMAGERY; CLASSIFICATION; ALGORITHMS; PATTERN; SPACE AB In this paper, we present a kernel realization of a matched subspace detector (MSD) that is based on a subspace mixture model defined in a high-dimensional feature space associated with a kernel function. The linear subspace mixture model for the MSD is first reformulated in a high-dimensional feature space and then the corresponding expression for the generalized likelihood ratio test (GLRT) is obtained for this model. The subspace mixture model in the feature space and its corresponding GLRT expression are equivalent to a nonlinear subspace mixture model with a corresponding nonlinear GLRT expression in the original input space. In order to address the intractability of the GLRT in the feature space, we kernelize the GLRT expression using the kernel eigenvector representations as well as the kernel trick where dot products in the feature space are implicitly computed by kernels. The proposed kernel-based nonlinear detector, so-called kernel matched subspace detector (KMSD), is applied to several hyperspectral images to detect targets of interest. KMSD showed superior detection performance over the conventional MSD when tested on several synthetic data and real hyperspectral imagery. C1 USA, Res Lab, ATTN, AMSRD ARL SE SE, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, ATTN, AMSRD ARL SE SE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM hkwon@arl.army.mil NR 22 TC 57 Z9 63 U1 0 U2 7 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0162-8828 J9 IEEE T PATTERN ANAL JI IEEE Trans. Pattern Anal. Mach. Intell. PD FEB PY 2006 VL 28 IS 2 BP 178 EP 194 DI 10.1109/TPAMI.2006.39 PG 17 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 991OY UT WOS:000233824500002 PM 16468616 ER PT J AU McKenzie, R Bourgeois, AL Engstrom, F Hall, E Chang, HS Gomes, JG Kyle, JL Cassels, F Turner, AK Randall, R Darsley, M Lee, C Bedford, P Shimko, J Sack, DA AF McKenzie, R Bourgeois, AL Engstrom, F Hall, E Chang, HS Gomes, JG Kyle, JL Cassels, F Turner, AK Randall, R Darsley, M Lee, C Bedford, P Shimko, J Sack, DA TI Comparative safety and immunogenicity of two attenuated enterotoxigenic Escherichia coli vaccine strains in healthy adults SO INFECTION AND IMMUNITY LA English DT Article ID B-SUBUNIT VACCINE; COLONIZATION FACTOR ANTIGENS; INTESTINAL IMMUNE-RESPONSES; SALMONELLA-TYPHIMURIUM; ANTIBODY-RESPONSES; VOLUNTEERS; CONSTRUCTION; MUTANTS; CHALLENGE; VIRULENCE AB A vaccine against enterotoxigenic Escherichia coli (ETEC) is needed to prevent diarrheal illness among children in developing countries and at-risk travelers. Two live attenuated ETEC strains, PTL002 and PTL003, which express the ETEC colonization factor CFA/II, were evaluated for safety and immunogenicity. In a randomized, double-blind, placebo-controlled trial, 19 subjects ingested one dose, and 21 subjects ingested two doses (days 0 and 10) of PTL-002 or PTL-003 at 2 X 109 CFU/dose. Anti-CFA/II mucosal immune responses were determined from the number of antibody-secreting cells (ASC) in blood measured by enzyme-linked immunospot assay, the antibody in lymphocyte supernatants (ALS) measured by enzyme-linked immunosorbent assay (ELISA), and fecal immunoglobulin A IgA) levels determined by ELISA. Time-resolved fluorescence (TRF) ELISA was more sensitive than standard colorimetric ELISA for measuring serum antibody responses to CFA/II and its components, CS1 and CS3. Both constructs were well tolerated. Mild diarrhea occurred after 2 of 31 doses (6%) of PTL-003. PTL-003 produced more sustained intestinal colonization than PTL-002 and better IgA response rates: 90% versus 55% (P = 0.01) for anti-CFA/II IgA-ASCs, 55% versus 30% (P = 0.11) for serum anti-CS1 IgA by TRF, and 65% versus 25% (P = 0.03) for serum anti-CS3 IgA by TRF. Serum IgG response rates to CS1 or CS3 were 55% in PTL-003 recipients and 15% in PTL-002 recipients (P = 0.02). Two doses of either strain were not significantly more immunogenic than one. Based on its superior immunogenicity, which was comparable to that of a virulent ETEC strain and other ETEC vaccine candidates, PTL-003 will be developed further as a component of a live, oral attenuated ETEC vaccine. C1 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD 21205 USA. USN, Med Res Ctr, Silver Spring, MD 20903 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Acambis Res Ltd, Cambridge CB1 9PT, England. Acambis Inc, Cambridge, England. RP McKenzie, R (reprint author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, 624 N Broadway,HH,Rm 203, Baltimore, MD 21205 USA. EM rmckenz@jhmi.edu NR 28 TC 20 Z9 23 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 2006 VL 74 IS 2 BP 994 EP 1000 DI 10.1128/IAI.74.2.994-1000.2006 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 009EC UT WOS:000235093100024 PM 16428745 ER PT J AU Naik, RS Krishnegowda, G Ockenhouse, CF Gowda, DC AF Naik, RS Krishnegowda, G Ockenhouse, CF Gowda, DC TI Naturally elicited antibodies to glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum require intact GPI structures for binding and are directed primarily against the conserved glycan moiety SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA PATHOGENESIS; IGG RESPONSES; IMMUNITY; MACROPHAGES; ASSOCIATION; TOXIN; PAPUA AB Immunization with a synthetic glycan corresponding to Plasmodium falciparum glycosylphosphatidylinositols (GPIs) has been proposed as a vaccination strategy against malaria. We investigated the structural requirements for binding of naturally elicited anti-GPI antibodies to parasite GPIs. The data show that anti-GPI antibody binding requires intact GPI structures and that the antibodies are directed predominantly against GPIs with a conserved glycan structure with three mannoses and marginally against the terminal fourth mannose. The results provide valuable insight for exploiting GPIs for the development of malaria vaccines. C1 Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA. Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Gowda, DC (reprint author), Penn State Univ, Coll Med, Dept Biochem & Mol Biol, 500 Univ Dr, Hershey, PA 17033 USA. EM gowda@psu.edu OI GOWDA, KRISHNE/0000-0002-6042-0520 FU NIAID NIH HHS [R01 AI041139, AI41139] NR 16 TC 16 Z9 16 U1 2 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 2006 VL 74 IS 2 BP 1412 EP 1415 DI 10.1128/IAI.74.2.1412-1415.2006 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 009EC UT WOS:000235093100074 PM 16428795 ER PT J AU Hulet, SW Sommerville, DR Crosier, RB Dabisch, PA Miller, DB Benton, BJ Forster, JS Scotto, JA Jarvis, JR Krauthauser, C Muse, WT Reutter, SA Mioduszewski, RJ Thomson, SA AF Hulet, SW Sommerville, DR Crosier, RB Dabisch, PA Miller, DB Benton, BJ Forster, JS Scotto, JA Jarvis, JR Krauthauser, C Muse, WT Reutter, SA Mioduszewski, RJ Thomson, SA TI Comparison of low-level sarin and cyclosarin vapor exposure on pupil size of the Gottingen minipig: Effects of exposure concentration and duration SO INHALATION TOXICOLOGY LA English DT Article ID LACRIMAL GLAND; CARBOXYLESTERASE; SPECIFICITY; TOXICITY; TIME AB The current studies estimated effective (miosis) concentrations of the nerve agents' sarin (GB) and cyclosarin (GF) as a function of exposure duration in the Gottingen minipig and determined dependency of the median effective dosage (ECT50) over time. Male and female Gottingen minipigs were exposed to various concentrations of vapor GB or GF for 10, 60, or 180 min. Infrared images of the pig's pupil before, during, and after nerve agent exposure were captured digitally and pupil area was quantified. An animal was classified "positive" for miosis if there was a 50% reduction in pupil area (as compared to baseline) at any time during or after the GB or GF exposure. Maximum likelihood estimation was used on the resulting quantal data to calculate ECT50 (miosis) values, with approximate 95% confidence intervals, for each of the six gender-exposure duration groups. As a group, male minipigs were significantly more sensitive to the pupil constricting effects of GF than were female minipigs. In male minipigs, GF is approximately equipotent to GB for 60-min exposures and more potent for 10- and 180-min exposures. In the female minipig GF is slightly more potent than GB for 10- min exposures but then progressively becomes less potent over the 60- and 180-min durations of exposure. The values of the toxic load exponents were essentially independent of the model fits used: 1.32 +/- 0.18 for GB exposures and 1.60 +/- 0.22 for GF exposures. Since neither of these intervals overlaps 1, Haber's rule is not an appropriate time-dependence model for these data sets. C1 USA, Edgewood Chem & Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Abingdon, MD USA. RP Hulet, SW (reprint author), USA, Edgewood Chem & Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. EM stanley.hulet@us.army.mil NR 36 TC 11 Z9 11 U1 2 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD FEB PY 2006 VL 18 IS 2 BP 143 EP 153 DI 10.1080/08958370500306131 PG 11 WC Toxicology SC Toxicology GA 998ZL UT WOS:000234358300004 PM 16393929 ER PT J AU Jensen, RE Palmese, GR McKnight, SH AF Jensen, RE Palmese, GR McKnight, SH TI Viscoelastic properties of alkoxy silane-epoxy interpenetrating networks SO INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES LA English DT Article DE interphase; silane; IPN; viscoelasticity ID FIBER-MATRIX ADHESION; CROSS-LINKED POLYMERS; COMPOSITE MECHANICAL-PROPERTIES; TUBE-JUNCTION MODEL; DIELECTRIC-RELAXATION; SURFACE-COATINGS; REINFORCED EPOXY; INTERPHASE; DYNAMICS; BLENDS AB A model epoxy-silane interpenetrating network (IPN) was synthesized to simulate the molecular structure found at the fibermatrix interphase. The Young's modulus (E) of the epoxy-silane IPN was determined through micromechanical analysis both quasistatically and in the frequency domain, The epoxy-silane IPN was synthesized by diffusion of uncured diglycidyl ether of bisphenol A (DGEBA) epoxy resin and his (p-aminocyclohexyl) methane (PACM) curing agent into spherical particles of condensed and crosslinked 3-glycidoxypropyltrimethoxysilane (GPS). This IPN composition was chosen to simulate the typical properties of a silane modified interphase found in glass reinforced composites. Differential scanning calorimetry (DSC) showed that the glass transition temperature (T-g) of the initial crosslinked siloxane network increases upon cure of the DGEBA and PACM, but was still significantly lower than that of the neat epoxy matrix. Additionally, dynamic mechanical analysis (DMA) was used in conjunction with the micromechanical C-Combining Rule to show that the Young's modulus of the epoxy-silane IPN spherical inclusions (E-i) is decreased in comparison to the Young's modulus of the matrix epoxy (E-m) at all temperatures. The time-temperature superposition (tTsp) principle was successfully applied to the epoxy-silane IPN to determine viscoelastic properties at high frequencies. The viscoelastic properties of the epoxy-silane IPN may have implications with respect to the ballistic impact resistance of composite structures used for Army applications. Published by Elsevier Ltd. C1 Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP McKnight, SH (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM shm@arl.army.mil NR 41 TC 20 Z9 20 U1 1 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-7496 J9 INT J ADHES ADHES JI Int. J. Adhes. Adhes. PD FEB-APR PY 2006 VL 26 IS 1-2 SI SI BP 103 EP 115 DI 10.1016/j.ijadhadh.2005.03.004 PG 13 WC Engineering, Chemical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 963UR UT WOS:000231832100012 ER PT J AU Crum, NF Riffenburgh, RH Wegner, S Agan, BK Tasker, SA Spooner, KM Armstrong, AW Fraser, S Wallace, MR AF Crum, NF Riffenburgh, RH Wegner, S Agan, BK Tasker, SA Spooner, KM Armstrong, AW Fraser, S Wallace, MR CA Triservice AIDS Clin Consortium TI Comparisons of causes of death and mortality rates among HIV-infected persons - Analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; AIDS; mortality; survival; cause of death ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS; SURVIVAL; DISEASE; ACCESS; TRENDS; IMPACT; ADULTS AB Methods: Comparisons of death-related variables during the 3 eras were performed. Results: The number of deaths declined over the study period, with 987 deaths in the pre-HAART era, 159 deaths in the early HAART era (1997-1999), and 78 deaths in the late HAART era (2000-2003) (P < 0.01). The annual death rate peaked in 1995 (10.3 per 100 patients) and then declined to < 2 deaths per 100 persons in the late HAART era (P < 0.01). The proportion of deaths attributable to infection decreased, but infection remained the leading cause of death in our cohort, followed by cancer. Of those who died, there was an increasing proportion of non-HIV-related deaths (32% vs. 9%; P < 0.01), including cardiac disease (22% vs. 8%; P < 0.01) and trauma (8% vs. 2%; P = 0.01) in the post-HAART versus pre-HAART era. Despite the absence of intravenous drug use and the low prevalence of hepatitis C coinfection in our cohort, an increasing proportion of deaths in the HAART era were attributable to liver disease, although the numbers are small. Conclusions: Despite increasing concerns regarding antiretroviral resistance, the death rate among HIV-infected persons in our cohort continues to decline. Our data show a lower death rate than that reported among many other US HIV-infected populations; this may be the result of open access to health care. A shift in the causes of death toward non-HIV-related causes suggests that a more comprehensive health care approach may be needed for optimal life expectancy; this may include enhanced screening for malignancy and heart disease as well as preventive measures for liver disease and accidents. C1 USN, Med Ctr, Dept Clin Invest, San Diego, CA 92134 USA. Triservice AIDS Clin Consortium, Rockville, MD USA. US Mil Acad, HIV Res Program, Rockville, MD USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. Natl Naval Med Res Inst, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, Med Ctr, Portsmouth, VA USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Crum, NF (reprint author), USN, Med Ctr, Dept Clin Invest, 34800 Bob Wilson Dr,Suite 5, San Diego, CA 92134 USA. EM nfcrum@nmcsd.med.navy.mil OI Agan, Brian/0000-0002-5114-1669 NR 35 TC 265 Z9 279 U1 4 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD FEB 1 PY 2006 VL 41 IS 2 BP 194 EP 200 DI 10.1097/01.qai.0000179459.31562.16 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 009GO UT WOS:000235100000011 PM 16394852 ER PT J AU Arora, R Kosisky, S Nelson, M AF Arora, R Kosisky, S Nelson, M TI Dilutions for quality control in the production do immunotherapy extract kits SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 295 BP S75 EP S75 DI 10.1016/j.jaci.2005.12.303 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865300295 ER PT J AU Chang, ST Klote, MM Nelson, MR Engler, RJM AF Chang, ST Klote, MM Nelson, MR Engler, RJM TI Immune response to influenza vaccination in subjects self reporting seasonal allergic rhinitis SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 804 BP S208 EP S208 DI 10.1016/j.jaci.2005.12.823 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301301 ER PT J AU Kaplan, MR Nelson, M Klote, M Engler, R AF Kaplan, MR Nelson, M Klote, M Engler, R TI Chest pain: An unrecognized side effect temporally associated with influenza vaccine SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 800 BP S207 EP S207 DI 10.1016/j.jaci.2005.12.819 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301297 ER PT J AU Klote, MM Nelson, MR Engler, RJM AF Klote, MM Nelson, MR Engler, RJM TI Local reactions and pain to trivalent inactivated influenza vaccine (TIV): Impact of gender and dose/volume (DV) SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 853 BP S221 EP S221 DI 10.1016/j.jaci.2005.12.873 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301350 ER PT J AU Lowe, KR Mikita, CP Klote, MM Nelson, MR AF Lowe, KR Mikita, CP Klote, MM Nelson, MR TI Diagnosis of common variable immunodeficiency in a patient with Evan's syndrome SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 679 BP S174 EP S174 DI 10.1016/j.jaci.2005.12.695 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301176 ER PT J AU Marks, SN Summers, DH Engler, RJM AF Marks, SN Summers, DH Engler, RJM TI Immunotherapy shot reaction manifesting with delayed-onset of severe, rapidly progressive anaphylaxis: Case report and post-event analysis SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Landstuhl Reg Med Ctr, Landstuhl, Germany. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 523 BP S134 EP S134 DI 10.1016/j.jaci.2005.12.536 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301020 ER PT J AU Yoon, I Martin, BL Carr, WW AF Yoon, I Martin, BL Carr, WW TI Comparison of two single-headed and two multiheaded prick skin test devices SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 03-07, 2006 CL Miami Beach, FL SP Amer Acad Allergy, Asthma & Immunol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2006 VL 117 IS 2 SU S MA 734 BP S189 EP S189 DI 10.1016/j.jaci.2005.12.751 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 019VR UT WOS:000235865301231 ER PT J AU Hurst, D Cedrone, N AF Hurst, D Cedrone, N TI Modafinil for drooling in cerebral palsy SO JOURNAL OF CHILD NEUROLOGY LA English DT Article ID BOTULINUM-TOXIN-A; PARKINSONS-DISEASE; CHILDREN; TRIAL; NARCOLEPSY; MANAGEMENT; INJECTIONS; BACLOFEN AB Two patients with spastic cerebral palsy recently treated with modafinil at the Walter Reed Army Medical Center child neurology clinic have stopped drooling. This occur-red after starting modafinil for spasticity and without other changes in the patients' treatment programs. The decrease in drooling is to a remarkable degree. Both patients had a chronic problem with drooling. One patient has gone from wearing a bib or bandanna, which was constantly wet from drooling to being essentially dry. After starting modafinil, both patients stopped drooling. The parents initially observed decreased drooling at home. Clinic appointment examinations and evaluations at physical therapy confirmed these observations. Better coordination and speech have been noted in each patient. Modafinil improves drooling in at least some patients with spastic cerebral palsy. The decreased drooling is due to improvements noted in swallowing. C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Hurst, D (reprint author), Walter Reed Army Med Ctr, Child & Adolescent Neurol Serv, Clin 1L,Bldg 2,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM daniel.hurst@na.amedd.army.mil NR 25 TC 3 Z9 3 U1 0 U2 1 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0883-0738 J9 J CHILD NEUROL JI J. Child Neurol. PD FEB PY 2006 VL 21 IS 2 BP 112 EP 114 DI 10.2310/7010.2006.00038 PG 3 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 046SS UT WOS:000237831900004 PM 16566873 ER PT J AU Lesho, EP Wortmann, GW Craft, D Moran, KA AF Lesho, EP Wortmann, GW Craft, D Moran, KA TI De novo daptomycin nonsusceptibility in a clinical isolate SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter ID ENTEROCOCCUS-FAECIUM; RESISTANT; BACTEREMIA; INFECTION; EMERGENCE C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lesho, EP (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Emil.Lesho@NA.amedd.army.mil NR 8 TC 22 Z9 23 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 2006 VL 44 IS 2 BP 673 EP 673 DI 10.1128/JCM.44.2.673.2006 PG 1 WC Microbiology SC Microbiology GA 012MV UT WOS:000235344200074 PM 16455945 ER PT J AU Hwang, S Felt, DR Bouwer, EJ Brooks, MC Larson, SL Davis, JL AF Hwang, S Felt, DR Bouwer, EJ Brooks, MC Larson, SL Davis, JL TI Remediation of RDX-contaminated water using alkaline hydrolysis SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID EXPLOSIVES; 1,3,5-TRIAZA-1,3,5-TRINITROCYCLOHEXANE; DENITRIFICATION; HMX AB The objective of this Study was to assess the effectiveness of alkaline hydrolysis as an alternative ex situ technology for remediating groundwater contaminated with hexahydro- 1,3,5-trinitro-1,3,5-triazine (RDX). Treatment in both batch reactor and continuous stirred tank reactor (CSTR) was investigated. RDX reactivity was strongly dependent on the reaction pH investigated (11-13). The batch system achieved pseudo-first-order RDX reaction rates in the range of (0.8-27.7) X 10(-3) min(-1), corresponding to half-life periods of 17.9 to 0.5 h, respectively. In the CSTR system operated at the initial RDX concentration of 4.5 X 10(-3) mM, 99% RDX removal was achieved with the hydraulic retention time of 2 days and the reaction pH of 11.9. Formate and nitrite were produced as the major hydrolysates in the CSTR system, indicating a simultaneous reaction mechanism involving RDX ring cleavage and elimination of the ring nitrogen. The net OH- demand used only for RDX removal in the CSTR was found to be 1.5 390, and 130 M OH-/M RDXremoved at pH values of 11.9, 11.5, and 11.0, respectively. A conceptual cost analysis indicated that the expense of alkaline treatment may be comparable to the expense of granular activated carbon treatment for long treatment periods (30 years or more), due to the potentially lower annual operational cost of alkali treatment. C1 Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00680 USA. US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. US EPA, Res & Dev Ctr, Enviornm Lab, Ada, OK 74820 USA. RP Hwang, S (reprint author), Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00680 USA. NR 17 TC 13 Z9 14 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD FEB PY 2006 VL 132 IS 2 BP 256 EP 262 DI 10.1061/(ASCE)0733-9372(2006)132:2(256) PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 004YE UT WOS:000234787800014 ER PT J AU Ojeda, L Borenstein, J Witus, G Karlsen, R AF Ojeda, Lauro Borenstein, Johann Witus, Gary Karlsen, Robert TI Terrain characterization and classification with a mobile robot SO JOURNAL OF FIELD ROBOTICS LA English DT Article; Proceedings Paper CT Conference on Unmanned Ground Vehicle Technology VII CY MAR 29-31, 2005 CL Orlando, FL SP SPIE, Ball Aerosp & Technol Corp, Univ Cent Florida, Coll Opt & Photon, Florida Space Inst, FOI, Swedish Defense Res Agcy, Univ Central Florida AB This paper introduces novel methods for terrain classification and characterization with a mobile robot. In the context of this paper, terrain classification aims at associating terrains with one of a few predefined, commonly known categories, such as gravel, sand, or asphalt. Terrain characterization, on the other hand, aims at determining key parameters of the terrain that affect its ability to support vehicular traffic. Such properties are collectively called "trafficability." The proposed terrain classification and characterization system comprises a skid-steer mobile robot, as well as some common and some uncommon but optional onboard sensors. Using these components, our system can characterize and classify terrain in real time and during the robot's actual mission. The paper presents experimental results for both the terrain classification and characterization methods. The methods proposed in this paper can likely also be implemented on tracked robots, although we did not test this option in our work. (c) 2006 Wiley Periodicals, Inc. C1 Univ Michigan, Dept Engn Mech, Ann Arbor, MI 48109 USA. Turing Associates Inc, Ann Arbor, MI 48103 USA. USA, TARDEC, AMSRD TAR R, Warren, MI 48397 USA. RP Ojeda, L (reprint author), Univ Michigan, Dept Engn Mech, Ann Arbor, MI 48109 USA. EM lojeda@umich.edu; johannb@umich.edu; witusg@umich.edu; karlsenr@tacom.arniy.mil NR 26 TC 60 Z9 63 U1 0 U2 11 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1556-4959 J9 J FIELD ROBOT JI J. Field Robot. PD FEB PY 2006 VL 23 IS 2 BP 103 EP 122 DI 10.1002/rob.20113 PG 20 WC Robotics SC Robotics GA 163GD UT WOS:000246146000002 ER PT J AU Tsokos, GC AF Tsokos, GC TI In the beginning was Sm SO JOURNAL OF IMMUNOLOGY LA English DT Editorial Material ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; SERA; MICE C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM gtsokos@usa.net NR 6 TC 4 Z9 4 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD FEB 1 PY 2006 VL 176 IS 3 BP 1295 EP 1296 PG 2 WC Immunology SC Immunology GA 004QF UT WOS:000234766600001 PM 16424152 ER PT J AU Moser, MJ Christensen, DR Norwood, D Prudent, JR AF Moser, MJ Christensen, DR Norwood, D Prudent, JR TI Multiplexed detection of anthrax-related toxin genes SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID BACILLUS-ANTHRACIS; ENZYMATIC INCORPORATION; ENERGY-TRANSFER; BASE PAIR; PCR; DNA; IDENTIFICATION; HYBRIDIZATION; FLUORESCENCE; AMPLIFICATION AB Simultaneous analysis of three targets in three colors on any real-time polymerase chain reaction (PCR) instrument would increase the flexibility of real-time PCR. For the detection of Bacillus strains that can cause inhalation anthrax-related illness, this ability would be valuable because two plasmids confer virulence, and internal positive controls are needed to monitor the testing in cases lacking target-specific signals. Using a real-time PCR platform called Multi-Code-RTx, multiple assays were developed that specifically monitor the presence of Bacillus anthracis-specific virulence plasmid-associated genes. In particular for use on LightCycler-1, two triplex RTx systems demonstrated high sensitivity with limits of detection nearing single-copy levels for both plasmids. Specificity was established using a combination of Ct values and correct amplicon melting temperatures. All reactions were further verified by detection of an internal positive control. For these two triplex RTx assays, the analytical detection limit was one to nine plasmid copy equivalents, 100% analytical specificity with a 95% confidence interval (CI) of 9%, and 100% analytical sensitivity with a CI of 2%. Although further testing using clinical or environmental samples will be required to assess diagnostic sensitivity and specificity, the RTx platform achieves similar results to those of probe-based real-time systems. C1 Eragen Biosci Inc, Madison, WI 53717 USA. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Prudent, JR (reprint author), Eragen Biosci Inc, 918 Deming Way, Madison, WI 53717 USA. EM jprudent@eragen.com FU NIAID NIH HHS [AI052898, R43 AI052898, R44 AI052898] NR 27 TC 19 Z9 19 U1 0 U2 2 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD FEB PY 2006 VL 8 IS 1 BP 89 EP 96 DI 10.2353/jmoldx.2006.050049 PG 8 WC Pathology SC Pathology GA 011CK UT WOS:000235245100012 PM 16436639 ER PT J AU Fan, C Kecskes, LJ Qiao, DC Choo, H Liaw, PK AF Fan, C Kecskes, LJ Qiao, DC Choo, H Liaw, PK TI Properties of as-cast and structurally relaxed Zr-based bulk metallic glasses SO JOURNAL OF NON-CRYSTALLINE SOLIDS LA English DT Article DE amorphous metals; metallic glasses; alloys; mechanical properties; strength; structural relaxation ID AL AMORPHOUS-ALLOYS; MECHANICAL-PROPERTIES; NANOCRYSTALLINE COMPOSITES; FORMING ABILITY; PARTICLES; STRENGTH; NB; PRECIPITATION; COMPOUND; BEHAVIOR AB We have studied the influence of the arc melting procedure of Nb-containing Zr-based bulk metallic glasses(BMGs) on their thermal and mechanical properties. We found that the strength and plastic strain to failure, determined at room temperature. increases by the addition of a few percentage of Nb into the Zr-based BMGs. High-resolution transmission-electron microscopy results Show that the addition of 2 at.% Nb introduces the formation of as-cast nanocrystals. At the same time, thermal analyses indicate an increase in glass forming ability with the small addition of Nb. Contrary to the reported results in other amorphous alloys. we found that the plastic strain increases further after heat-induced structural relaxation in the Zr-based BMGs. (c) 2005 Elsevier B.V. All rights reserved. C1 Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Oak Ridge Natl Lab, Div Met & Ceram, Oak Ridge, TN 37831 USA. RP Fan, C (reprint author), Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA. EM cfan@utk.edu RI Choo, Hahn/A-5494-2009; Kecskes, Laszlo/F-6880-2014 OI Choo, Hahn/0000-0002-8006-8907; Kecskes, Laszlo/0000-0002-1342-3729 NR 26 TC 9 Z9 9 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3093 J9 J NON-CRYST SOLIDS JI J. Non-Cryst. Solids PD FEB 1 PY 2006 VL 352 IS 2 BP 174 EP 179 DI 10.1016/j.jnoncrysol.2005.11.016 PG 6 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA 007IT UT WOS:000234963000012 ER PT J AU Gliddon, MJ Xia, JJ Gateno, J Wong, HTF Lasky, RE Teichgraeber, JF Jia, XL Liebschner, MAK Lemoine, JJ AF Gliddon, MJ Xia, JJ Gateno, J Wong, HTF Lasky, RE Teichgraeber, JF Jia, XL Liebschner, MAK Lemoine, JJ TI The accuracy of cephalometric tracing superimposition SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article; Proceedings Paper CT 85th Annual Meeting of the American-Association-of-Oral-Maxillofacial-Surgeons CY SEP 10-14, 2003 CL Orlando, FL SP Amer Assoc Oral & Maxillofacial Surg ID LANDMARKS AB Purpose: The purpose of this study was to compare the accuracy of 4 methods for cephalometric tracing superimposition. They are the FH@Porion method, S-N@Sella method, least-squared averaged 5 landmarks (LS-5) method, and manual geometric method. Materials and Methods: Eight lateral cephalometric radiographs were used. Cephalometric tracing was performed by 2 examiners. One had extensive experience in landmark digitization while the other had minimal experience. The radiographs were scanned and the reference landmarks ANS, Point A, Point B, and Pogonion were digitized, creating 8 master tracings. Then 6 digital copies of each master tracing were made, 3 for each examiner. Subsequently, the examiners were asked to digitize and trace predetermined cranial base landmarks and structures. Tracings occurred at 1-month intervals. As a result, 3 separate tracings of each set were obtained from each examiner. The tracings of each set were superimposed using 4 different methods in the CASSOS software (SoftEnable Technology Ltd, Hong Kong SAR, China). For each method of superimposition, the coordinates of ANS, Point A, Point B, and Pogonion were recorded. Their meat-is and variances were calculated. The variance represents the variability of the superimposition method. A general linear model for repeated measures was computed to test whether there were statistically significant differences among the 4 superimposition methods, 2 examiners, 4 reference landmarks, and 2 directions. Because the distribution of the variances was skewed, they were transformed to log variances. Finally, the errors of the superimposition in millimeters for each given examiner, superimposition method, reference landmark, and direction (X, Y) were calculated. Results: There was a statistically significant difference in measurement variability among the 4 superimposition methods (P < .001). For both examiners, the variability of the different superimposition methods from the highest to the lowest was: Frankfort Plane registered at Porion method, Sella-Nasion registered at Sella method, least-square averaged 5 landmarks method, and the manual geometric method. In addition, there was a statistically significant difference in the magnitude of superimposition errors between the 2 examiners (P < .001). The experienced examiner was consistently more precise than the inexperienced examiner across all methods. Moreover, there was a statistically significant difference among 4 reference landmarks (P < .001). For both examiners, the recorded variability of each given reference landmark from the lowest to the highest was: ANS, Point A, Point B, and Pogonion. Furthermore, the variability differences between horizontal and vertical directions did not reach a conventional level of significance (P = .123). Finally, the recorded errors in millimeters for each superimposition method were summarized. A smaller error in millimeters represented a higher accuracy in superimposition. The error of using manual geometric or LS-5 methods for both examiners was less than 0.50 mm, while the error of using the other 2 methods was up to 0.99 mm for the experienced examiner and 2.88 mm for the inexperienced examiner. Conclusion: The error of both manual and LS-5 methods was within 0.5 mm. The LS-5 method had its advantage because it could be automated by the computer. (c) 2006 American Association of Oral and Maxillofacial Surgeons. C1 Reynolds Army Community Hosp, Dept Oral & Maxillofacial Surg, Ft Sill, OK USA. Univ Texas, Hlth Sci Ctr, Dept Oral & Maxillofacial Surg, Dent Branch, Houston, TX USA. Univ Texas, Hlth Sci Ctr, Div Pediat Plast Surg, Dept Surg,Sch Med, Houston, TX USA. City Univ Hong Kong, Dept Comp Sci, Hong Kong, Hong Kong, Peoples R China. Univ Texas, Hlth Sci Ctr, Dept Pediat, Houston, TX 77225 USA. Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, Houston, TX 77225 USA. Univ Texas, Med Branch, Dept Internal Med, Galveston, TX 77550 USA. Rice Univ, Dept Bioengn, Houston, TX 77251 USA. RP Xia, JJ (reprint author), 6560 Fannin St,Suite 1228, Houston, TX 77030 USA. EM JXia@tmh.tmc.edu NR 10 TC 17 Z9 18 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD FEB PY 2006 VL 64 IS 2 BP 194 EP 202 DI 10.1016/j.joms.2005.10.028 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 005PV UT WOS:000234837200008 PM 16413890 ER PT J AU Kennedy, RH Hutcherson, KJ Kain, JB Phillips, AL Halle, JS Greathouse, DG AF Kennedy, RH Hutcherson, KJ Kain, JB Phillips, AL Halle, JS Greathouse, DG TI Median and ulnar neuropathies in university guitarists SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE median nerve; nerve conduction stud; ulnar nerve ID CARPAL-TUNNEL-SYNDROME; SENSORY NERVE-CONDUCTION; INSTRUMENTAL MUSICIANS; MUSCULOSKELETAL DISORDERS; DIAGNOSTIC UTILITY; GENERAL-POPULATION; PRACTICE PARAMETER; OVERUSE SYNDROME; PREVALENCE; TESTS AB Study Design: Descriptive study. Objectives: To determine the presence of median and ulnar neuropathies in both upper extremities of university guitarists. Background: Peripheral nerve entrapment syndromes of the upper extremities are well documented in musicians. Guitarists and plucked-string musicians are at risk for entrapment neuropathies in the upper extremities and are prone to mild neurologic deficits. Methods and Measures: Twenty-four volunteer male and female guitarists (age range, 18-26 years) were recruited from the Belmont University School of Music and the Vranderbilt University Blair School of Music. Individuals were excluded if they were pregnant or had a history of recent upper extremity or neck injury. Subjects completed a history form, were interviewed, and underwent a physical examination. Nerve conduction status of the median and ulnar nerves of both upper extremities was obtained by performing motor, sensory, and F-Nave (central) nerve conduction studies. Descriptive statistics of the nerve conduction study variables were computed using Microsoft Excel. Results: Six subjects had positive findings on provocative testing of the median and ulnar nerves. Otherwise, these guitarists had normal upper extremity neural and musculoskeletal function based on the history and physical examinations. When comparing the subjects' nerve conduction study values with a chart of normal nerve conduction studies values, 2 subjects had prolonged distal motor latencies (DMLs) of the left median nerve of 4.3 and 4.7 milliseconds (normal, < 4.2 milliseconds). Prolonged DMLs are compatible with median neuropathy at or distal to the wrist. Otherwise, all electrophysiological variables were within normal limits for motor, sensory, and F-wave (central) values. However, comparison studies of median and ulnar motor latencies in the same hand demonstrated prolonged differences of greater than 1.0 milliseconds that affected the median nerve in 2 additional subjects, and identified contralateral limb involvement in a subject with a prolonged distal latency. The other 20 subjects demonstrated normal comparison studies of the median and ulnar nerves in both upper extremities. Conclusions: In this descriptive study of a population of 24 university guitarists, 4 musicians (17%) were found to have electrophysiologic evidence of median neuropathy at or distal to the wrist or carpal tunnel syndrome. Ulnar nerve electrophysiological function was within normal limits for all subjects examined. C1 Belmont Univ, Phys Therapy Program, Nashville, TN USA. Belmont Univ, Neurol Clin, Blanchfield Army Community Hosp, Sch Phys Therapy, Ft Campbell, KY USA. Texas Phys Therapy Specialists, Clin Electrophysiol Serv, New Braunfels, TX USA. Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. Belmont Univ, Sch Phys Therapy, Nashville, TN USA. RP Greathouse, DG (reprint author), 3211 Crystal Path, San Antonio, TX 78259 USA. EM greathoused1@yahoo.com NR 61 TC 9 Z9 9 U1 2 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 2006 VL 36 IS 2 BP 101 EP 111 PG 11 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 008LR UT WOS:000235042700007 PM 16494077 ER PT J AU Sullivan, JS Stewart, A Bounngaseng, A Sullivan, JJ Nace, D Williams, A Galland, GG Williams, T Fleetwood, HT Collins, WE AF Sullivan, JS Stewart, A Bounngaseng, A Sullivan, JJ Nace, D Williams, A Galland, GG Williams, T Fleetwood, HT Collins, WE TI Observations on the exoerythrocytic stages of different isolates of Plasmodium cynomolgi in hepatocytes of new world Aotus and Saimiri monkeys SO JOURNAL OF PARASITOLOGY LA English DT Article ID TRIVIRGATUS MONKEYS; BOLIVIENSIS MONKEYS; TRANSMISSION; INFECTION; KNOWLESI; STRAIN AB Sporozoites of 3 isolates of Plasmodium cynomolgi dissected from the salivary glands of Anopheles dirus and Anopheles quadrimaculatus were injected intravenously into 9 New World monkeys. Liver stage parasites were demonstrated in all 9 animals; 7 of these animals also produced blood stages after prepatent periods of 9 to 23 days. C1 Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA 30341 USA. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Sci Resources Program, Atlanta, GA 30341 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Atlanta Res & Educ Fdn, Atlanta, GA 30033 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA 30341 USA. EM wec1@cdc.gov NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 J9 J PARASITOL JI J. Parasitol. PD FEB PY 2006 VL 92 IS 1 BP 202 EP 205 DI 10.1645/GE-3520RN.1 PG 4 WC Parasitology SC Parasitology GA 029MB UT WOS:000236565900037 PM 16629341 ER PT J AU Rollings, RS Rollings, MP Poole, T Wong, GS Gutierrez, G AF Rollings, RS Rollings, MP Poole, T Wong, GS Gutierrez, G TI Investigation of heaving at Holloman Air Force Base, New Mexico SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article AB Heaving of pavements and a building foundation became progressively worse on a project at Holloman Air Force Base (AFB), N.M. The cause of the heaving was identified as sulfate attack on recycled concrete used as fill and base course below the buildings and pavements. This recycled concrete came from sulfate-resistant airfield Portland concrete pavement that had existed for decades at Holloman AFB without distress. However, severe sulfate exposure conditions, ready availability of water, the more permeable nature of the crushed recycled concrete, less common thaumasite attack, possible soil contamination as a secondary source of alumina, or some combination of these factors allowed sulfate attack to develop in the recycled material even though it had not in the original concrete pavement. C1 Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Erdc, Geotech & Struct Lab, Hanover, NH 03755 USA. USA, Albuquerque, NM USA. RP Rollings, RS (reprint author), Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM rrollings@errel.usace.army.mil; mrollings@crrel.usace.army.mil; tpoole@wes.army.mil; gwong@wes.army.mil; ggutierez@spa.usace.army.mil NR 12 TC 3 Z9 3 U1 2 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD FEB PY 2006 VL 20 IS 1 BP 54 EP 63 DI 10.1061/(ASCE)0887-3828(2006)20:(54) PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 004UZ UT WOS:000234779300008 ER PT J AU Takacs, G Cameron, SM AF Takacs, G Cameron, SM TI An investment technique for custom dental implant abutments SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA, Dent Activ, Prosthodont Residency Program, Ft Gordon, GA 30905 USA. RP Cameron, SM (reprint author), 1533 Clary Cut Rd, Appling, GA 30802 USA. EM stephen.cameron@se.amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 2006 VL 95 IS 2 BP 168 EP 168 DI 10.1016/j.prosdent.2005.11.011 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 014PL UT WOS:000235492100014 PM 16473093 ER PT J AU Bailey, MB Curtiss, P Blanton, PH McBrayer, TB AF Bailey, MB Curtiss, P Blanton, PH McBrayer, TB TI Exergetic, thermal, and externalities analyses of a cogeneration plant SO JOURNAL OF SOLAR ENERGY ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID AIR-POLLUTION; IMPACT AB A thermodynamic study of an 88.4 MW cogeneration plant located in the United States is presented in this paper. The feedstock for this actual plant is culm, the waste left from anthracite coal mining. Before combustion in circulating fluidized bed boilers, the usable carbon within the culm is separated from the indigenous rock. The rock and ash waste from the combustion process fill adjacent land previously scared by strip mining. Trees and gross are planted in these areas as part of a land reclamation program. Analyses based oil the first and second laws of thermodynamics using actual operating data are first presented to acquaint the reader with the plant's components and operation. Using emission and other relevant environmental data from the plant, all externalities study is outlined that estimates the plant's effect on the local population. The results show that the plant's cycle performs with a coefficient of utilization of 29% and all approximate exergetic efficiency of 34.5%. In order to increase these values, recommended improvements to the plant are noted. In addition, the externality costs associated with the estimated SO2. and NOX discharge from the culm fed plant are approximately 1 mil/kW h produced. This is considerably lower (85-95%) than those associated with a similarly sized coal fed plant. The plant's cycle efficiencies are lower than those associated with more modern technologies; such as all integrated gas turbine combined cycle. However, given the abundant, inexpensive supply of feedstock located adjacent to the plant and the environmental benefit of removing culm banks, the plant's existing operation is unique front an economical and environmental viewpoint. C1 Rochester Inst Technol, Dept Mech Engn, Rochester, NY 14623 USA. Curtiss Engn, Boulder, CO USA. USA, Worthington, OH 43085 USA. USA, Midland, TX 79701 USA. RP Bailey, MB (reprint author), Rochester Inst Technol, Dept Mech Engn, Rochester, NY 14623 USA. EM margaret.bailey@rit.edu; peter@petercurtiss.com NR 17 TC 0 Z9 0 U1 0 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0199-6231 J9 J SOL ENERG-T ASME JI J. Sol. Energy Eng. Trans.-ASME PD FEB PY 2006 VL 128 IS 1 BP 98 EP 103 DI 10.1115/1.2148973 PG 6 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA 012ZX UT WOS:000235380500016 ER PT J AU Watson, S AF Watson, S TI Divided union: The politics of war in the early American republic. SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD FEB PY 2006 VL 72 IS 1 BP 164 EP 166 PG 3 WC History SC History GA 011SA UT WOS:000235287200019 ER PT J AU Vaccaro, AR Lim, MR Hurlbert, RJ Lehman, RA Harrop, J Fisher, DC Dvorak, M Anderson, DG Zeiller, SC Lee, DY Fehlings, MG Oner, FC AF Vaccaro, AR Lim, MR Hurlbert, RJ Lehman, RA Harrop, J Fisher, DC Dvorak, M Anderson, DG Zeiller, SC Lee, DY Fehlings, MG Oner, FC CA Spine Trauma Study Grp TI Surgical decision making for unstable thoracolumbar spine injuries - Results of a consensus panel review by the Spine Trauma Study Group SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE spinal trauma; classification systems; clinical pathways; surgical approach ID LUMBAR BURST FRACTURES; ANTERIOR DECOMPRESSION; NONOPERATIVE TREATMENT; NEUROLOGIC DEFICIT; CORD-INJURY; STABILIZATION; INSTRUMENTATION; COMPLICATIONS; MANAGEMENT; FIXATION AB Objectives: The optimal Surgical approach and treatment of unstable thoracolumbar spine injuries arc poorly defined owing to a lack of widely accepted level I clinical literature. This lack of evidence-based standards has led to varied practice patterns based oil individual surgeon preferences. The purpose of this study was to survey the leaders in the field of spine trauma to define the major characteristics of thoracolumbar injuries that influence their Surgical decision making. In the absence of good scientific data, expert consensus opinions may provide surgeons with a practical framework to guide therapy and to conduct future research. Methods: A panel of 22 leading spinal surgeons from 20 level 1 trauma centers in seven countries met to discuss the indications for surgical approach selection in unstable thoracolumbar injuries. Injuries were presented to the surgeons in a case scenario survey format. Preferred surgical approaches to the clinical scenarios were tabulated and comments weighed. Results: All members of the panel agreed that three independent characteristics of thoracolumbar injuries carry primary importance inSurgical decision making: the injury morphology, the neurologic status of the patient, and the integrity of the posterior ligaments. Six clinical scenarios based on the neurologic status of the patient (intact, incomplete, or complete) and on the status of the posterior ligamentous complex (intact or disrupted) were created, and consensus treatment approaches were described. Additional circumstances capable of altering the treatments were acknowledged. Conclusions: Decision making for the surgical treatment of thoracolumbar injuries is largely dependent oil three patient characteristics: injury morphology, neurologic status, and posterior ligament integrity. A logical and practical decision-making process based on these characteristics may guide treatment even for the most complicated fracture patterns. C1 Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. Vancouver Gen Hosp, Div Orthoped Surg, Vancouver, BC, Canada. Univ Utrecht, Med Ctr, Div Orthopaed Surg, NL-3508 TC Utrecht, Netherlands. Dept Clin Neurosci, Calgary, AB, Canada. Univ Calgary, Foothills Hosp, Calgary Spine Program, Calgary, AB, Canada. Foothills Prov Gen Hosp, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada. Med Ctr, Calgary, AB, Canada. Univ Toronto, Sprinal Program, Div Neurosurg, Toronto, ON, Canada. Univ Toronto, Hlth Network, Krembil Neurosci Ctr, Toronto, ON, Canada. RP Vaccaro, AR (reprint author), Rothman Inst, 925 Chestnut St,5th Fl, Philadelphia, PA 19107 USA. EM alexvaccaro3@aol.com RI Oner, FC/L-7769-2013 OI Oner, FC/0000-0003-0858-8243 NR 44 TC 59 Z9 78 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD FEB PY 2006 VL 19 IS 1 BP 1 EP 10 DI 10.1097/01.bsd.0000180080.59559.45 PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 029JL UT WOS:000236558400001 PM 16462211 ER PT J AU Lauer, AM Dooling, RJ Leek, MR Lentz, JJ AF Lauer, AM Dooling, RJ Leek, MR Lentz, JJ TI Phase effects in masking by harmonic complexes in birds SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article; Proceedings Paper CT 6th International Congress of Neuroethology CY JUL 29-AUG 03, 2001 CL BONN, GERMANY ID BUDGERIGARS MELOPSITTACUS-UNDULATUS; BASILAR-MEMBRANE; PERIOD PATTERNS; INNER-EAR; HEARING; DISPERSION; PAPILLA AB Masking by harmonic complexes depends on the frequency content of the masker and its phase spectrum. Harmonic complexes created with negative Schroeder phases (component phases decreasing with increasing frequency) produce more masking than those with positive Schroeder phases (increasing phase) in humans, but not in birds. The masking differences in humans have been attributed to interactions between the masker phase spectrum and the phase characteristic of the basilar membrane. In birds, the similarity in masking by positive and negative Schroeder maskers, and reduced masking by cosine-phase maskers (constant phase), suggests a phase characteristic that does not change much along the basilar papilla. To evaluate this possibility, the rate of phase change across masker bandwidth was varied by systematically altering the Schroeder algorithm. Humans and three species of birds detected tones added in phase to a single component of a harmonic complex. As observed in earlier studies, the minimum amount of masking in humans occurred for positive phase gradients. However, minimum masking in birds occurred for a shallow negative phase gradient. These results suggest a cochlear delay in birds that is reduced compared to that found in humans, probably related to the shorter avian basilar epithelia. (c) 2006 Acoustical Society of America. C1 Univ Maryland, Dept Psychol, College Pk, MD 20742 USA. Univ Maryland, Ctr Comparat & Evolutionary Biol Hearing, College Pk, MD 20742 USA. Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA. RP Lauer, AM (reprint author), Univ Maryland, Dept Psychol, College Pk, MD 20742 USA. EM alauer@psyc.umd.edu OI Lauer, Amanda/0000-0003-4184-7374 FU NIDCD NIH HHS [DC-04664-01A2, P30 DC004664, DC-00626, F31 DC005450, DC-005450, R01 DC000626, R01 DC001372, DC-01372] NR 28 TC 8 Z9 8 U1 1 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2006 VL 119 IS 2 BP 1251 EP 1259 DI 10.1121/1.2151816 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 014DD UT WOS:000235458100061 PM 16521786 ER PT J AU McClung, JP Marchitelli, LJ Friedl, KE Young, AJ AF McClung, JP Marchitelli, LJ Friedl, KE Young, AJ TI Prevalence of iron deficiency and iron deficiency anemia among three populations of female military personnel in the US Army SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article DE military personnel; iron; iron deficiency; anemia ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; MEXICAN-AMERICAN; NONANEMIC WOMEN; UNITED-STATES; EXERCISE; SUPPLEMENTATION; MEN; ENDURANCE; CAPACITY AB Background: Iron deficiency is the most prevalent micronutrient deficiency disease in the world and occurs in young women in the United States. Female military personnel represent a unique population faced with intense physical and cognitive demands. Objective: The objective of this study was to determine the prevalence of iron deficiency and iron deficiency anemia among three populations of female military personnel in the US Army. Methods: Iron status was assessed in 1216 volunteers. Volunteers were recruited from three groups: immediately following initial entry to the Army (IET), immediately following basic combat training (AIT), or following at least six months of permanent assignment (PP). Iron deficiency was determined using a three variable model, including cut-off values for serum ferritin, transferrin saturation, and red cell distribution width (RDW). Iron deficiency anemia was categorized by iron deficiency and a hemoglobin (Hgb) value of < 12 g/dL. Results: The prevalence of iron deficiency was greater in women in the AIT group (32.8%) than in the IET and PP groups (13.4 and 9.6%, respectively). The prevalence of iron deficiency anemia was greater in the AIT group (20.9%) than in the IET and PP groups (5.8 and 4.8%, respectively). Furthermore, the prevalence of iron deficiency anemia was greater in Hispanic (21.9%) and African-American military personnel (22.9%) than in Caucasian military personnel (10.5%). Conclusions: These data indicate that female military personnel experience diminished iron status following training, and that iron nutriture is an important issue facing females in the military. C1 USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM James.McClung@na.amedd.army.mil RI McClung, James/A-1989-2009; OI Friedl, Karl/0000-0002-3134-8427 NR 29 TC 45 Z9 46 U1 0 U2 11 PU AMER COLLEGE NUTRITION PI CLEARWATER PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD FEB PY 2006 VL 25 IS 1 BP 64 EP 69 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 027NA UT WOS:000236421100009 PM 16522934 ER PT J AU Steiner, WE Harden, CS Hong, F Klopsch, SJ Hill, HH McHugh, VM AF Steiner, WE Harden, CS Hong, F Klopsch, SJ Hill, HH McHugh, VM TI Detection of aqueous phase chemical warfare agent degradation products by negative mode ion mobility time-of-flight mass spectrometry [IM(tof)MS] SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article ID ALKYL METHYLPHOSPHONIC ACIDS; HYDROLYSIS PRODUCTS; GAS-CHROMATOGRAPHY; SULFUR MUSTARD; NERVE-GAS; ELECTROSPRAY; IONIZATION; SARIN; SOMAN; IDENTIFICATION AB The use of negative ion monitoring mode with an atmospheric pressure ion mobility orthogonal reflector time-of-flight mass spectrometer [IM(tof)MS] to detect chemical warfare agent (CWA) degradation products from aqueous phase samples has been determined. Aqueous phase sampling used a traditional electrospray ionization (ESI) source for sample introduction and ionization. Certified reference materials (CRM) of CWA degradation products for the detection of Schedule 1, 2, or 3 toxic chemicals or their precursors as defined by the chemical warfare convention (CWC) treaty verification were used in this study. A mixture of six G-series nerve related CWA degradation products (EMPA, IMPA, EHEP, IHEP, CHMPA, and PMPA) and their related collision induced dissociation (CID) fragment ions (MPA and EPA) were found in each case to be clearly resolved and detected using the IM(tof)MS instrument in negative ion monitoring mode. Corresponding ions, masses, drift times, K-o values, and signal intensities for each of the CWA degradation products are reported. C1 Washington State Univ, Dept Chem, Pullman, WA 99164 USA. SAIC Geo Ctr, Edgewood Chem Biol Ctr Operat, Aberdeen Proving Ground, MD USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Hill, HH (reprint author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA. EM hhhill@wsu.edu NR 76 TC 31 Z9 33 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1044-0305 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD FEB PY 2006 VL 17 IS 2 BP 241 EP 245 DI 10.1016/j.jasms.2005.11.004 PG 5 WC Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA 012ZF UT WOS:000235378700015 PM 16413205 ER PT J AU Barrier, BF Kendall, BS Sharpe-Timms, KL Kost, ER AF Barrier, BF Kendall, BS Sharpe-Timms, KL Kost, ER TI Human Leukocyte Antigen-G (HLA-G) is expressed by endometrial adenocarcinoma: In utero expression correlates with the presence of metastatic disease. SO JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION LA English DT Meeting Abstract CT 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation CY MAR 22-25, 2006 CL Toronto, CANADA SP Soc Gynecolog Investigation C1 Univ Missouri, Dept Obstet Gynecol & Womens Hlth, Columbia, MO USA. Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX USA. Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1071-5576 J9 J SOC GYNECOL INVEST JI J. Soc. Gynecol. Invest. PD FEB PY 2006 VL 13 IS 2 SU S MA 312 BP 165A EP 165A PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 017KZ UT WOS:000235693800311 ER PT J AU Pursifull, NF Morris, MS Harris, RA Morey, AF AF Pursifull, NF Morris, MS Harris, RA Morey, AF TI Damage control management of experimental grade 5 renal injuries: Further evaluation of FloSeal gelatin matrix SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE trauma; kidney; gelatin matrix; hemostasis; damage control ID V LIVER-INJURIES; NEPHRON-SPARING SURGERY; THROMBIN TISSUE SEALANT; OPERATIVE MANAGEMENT; PARTIAL NEPHRECTOMY; COAGULOPATHIC PIGS; TRAUMA; SWINE AB Background: We developed a porcine grade 5 renal laceration damage control model to evaluate the hemostatic efficacy of FloSeal gelatin matrix (Baxter Healthcare, Corp., Deerfield, III). Methods: Ten commercial swine underwent celiotomy, contralateral nephrectomy, and cooling to 32 degrees C after a well-established hypothermia protocol to simulate a damage control scenario. Following prospective randomization, a complex grade 5 renal injury was uniformly produced on the remaining kidney. Control animals (group 1, n = 5) were treated with direct manual compression with a gelatin sponge. Experimental animals (group 2, n = 5) were treated by application of FloSeal gelatin matrix followed by direct compression with a gelatin sponge. Operative blood loss and efficacy of hemostasis were compared. Creatinine levels were obtained daily until postoperative day 7. Abdominal computed tomography was performed at 10 days. Results: Use of FloSeal gelatin matrix hemostatic sealant resulted in significantly less mean blood loss than gelatin sponge bolster compression alone (202.4 mL vs. 540.4 mL, respectively, p = 0.016). Hemostasis was complete in 60% (three out of five) of experimental animals after 2 minutes, but was incomplete in all control animals. After an initial increase, serum creatinine approached baseline by postoperative day 7 in all animals. Axial imaging 10 days postoperatively revealed no evidence of significant delayed perirenal hemorrhage. Conclusions: FloSeal gelatin matrix performed well as a rapidly deployable, effective hemostatic agent in a hypothermic grade 5 renal injury damage control model. The absence of delayed bleeding and nephrotoxicity suggests a possible increased role for FloSeal in the treatment of devastating renal injuries in damage control surgery. C1 Brooke Army Med Ctr, Serv Urol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Serv Urol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM allen.morey@amedd.army.mil NR 24 TC 19 Z9 21 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2006 VL 60 IS 2 BP 346 EP 350 DI 10.1097/01.ta.0000202514.96964.85 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 018MF UT WOS:000235767700019 PM 16508494 ER PT J AU Cooke, WH Salinas, J Convertino, VA Ludwig, DA Hinds, D Duke, AH Moore, FA Holcomb, JB AF Cooke, WH Salinas, J Convertino, VA Ludwig, DA Hinds, D Duke, AH Moore, FA Holcomb, JB TI Heart rate variability and its association with mortality in prehospital trauma patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE power spectral analysis; trauma vitals database; autonomic balance ID SPECTRAL-ANALYSIS; SYMPATHOVAGAL BALANCE; DEATH; PRESSURE; RHYTHMS; HUMANS; INJURY; PROBE; SHOCK; TILT AB Background: Accurate prehospital triage of trauma patients is difficult, especially in mass casualty situations. Accordingly, the U.S. Military has initiated a program directed toward improving noninvasive prehospital triage algorithms based on available physiologic data. The purpose of this study was to assess heart rate variability and its association with mortality in prehospital trauma patients. Methods: Trauma patients without significant head injury requiring helicopter transport were identified from a retrospective research database. An equal number, unmatched sample of patients who lived were compared with those who died (n = 15 per group). All patients were transported to a single Level I urban trauma center. The primary independent variable was mortality. Patients with Abbreviated Injury Scale head scores > 2 were excluded from the analysis, so that the effects seen were based on hemorrhagic shock. Age, sex, Glasgow Coma Scale score (GCS), blood pressure, pulse pressure, pulse, intubation rate, SpO(2), mechanism of injury, transport time, and time of death after admission were recorded. R-waves from the first available 120 seconds of usable data were detected from normal electrocardiograms and heart rate variability was assessed. Results. Patients who died demonstrated a lower GCS (7.9 +/- 1.4 versus 14.4 +/- 0.2; p = 0.0001) and higher intubation rate (53% of patients who died versus 0% patients who lived). Pulse rate, arterial pressure, and SpO(2) were not distinguishable statistically between groups (p = 0.08), but pulse pressure was lower in patients who died (39 3 versus 50 2 mm Hg; p = 0.01). Compared with patients who lived, those who died had lower normalized low-frequency (LF) power (42 +/- 6 versus 62 +/- 4 LFnu; p = 0.009), higher high-frequency (HF) power (42 +/- 3 versus 32 +/- 3 HFnu; p 0.04) and higher HF-to-LF ratio (144 +/- 30 versus 62 +/- 11(nu); p = 0.01). With absolute HF/LF adjusted for GCS, the intergroup variance accounted for by HF/LF was reduced to 6% (p = 0.16). Conclusions: Analysis of heart rate variability provides insight into adequacy of autonomic compensation to severe trauma. In our cohort of trauma patients, low pulse pressures coupled with relatively higher parasympathetic than sympathetic modulation characterized and separated patients who died versus patients who survived traumatic injuries when standard physiologic measurements are not different. These data do not suggest advantages of heart rate variability analysis over GCS scores, but suggest future possibilities for remote noninvasive triage of casualties when GCS scores are unattainable. C1 Univ Texas, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA. Univ Texas, Ctr Hlth Sci, Dept Surg, Houston, TX USA. RP Cooke, WH (reprint author), Univ Texas, Dept Hlth & Kinesiol, 6900 N Loop,1604 W, San Antonio, TX 78249 USA. NR 25 TC 88 Z9 89 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2006 VL 60 IS 2 BP 363 EP 370 DI 10.1097/01.ta.0000196623.48952.0e PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 018MF UT WOS:000235767700022 PM 16508497 ER PT J AU Klemcke, HG AF Klemcke, HG TI Evaluation of FloSeal as a potential intracavitary hemostatic agent SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID VASCULAR-SURGERY; FIBRIN SEALANT; LIVER-INJURIES; DEATH AB Background. Noncompressible hemorrhage is a major cause of death in combat and civilian trauma. When surgery is unavailable, one potential solution to such hemorrhage might be the introduction of an agent into the closed body cavity to provide hemostasis via a combination of coagulative and tamponade effects. FloSeal is an agent containing collagen and thrombin with proven hemostatic efficacy when applied with manual pressure to a bleeding site. The current studies were conducted to analyze the ability of FloSeal to reduce blood loss and increase survival time when applied directly, immediately, and without additional pressure to a severe liver injury in rats. Methods: Male rats were anesthetized and catheters were placed in the carotid artery (for measurement of blood pressure) and jugular vein (for resuscitation with lactated Ringers, 3.3 mL/min/kg BW). After midventral laparotomy, the liver was exposed and caudal portions of both medial lobes (similar to 1% of body weight) were rapidly excised. FloSeal (5 mL, 800 units Thrombin/mL) or vehicle (5 mL, 0.9% NaCl) was directly and immediately applied to the cut liver surface. The abdominal cavity was closed and resuscitation initiated. After hemorrhage-induced death, or after euthanasia at 90 minutes, fluid loss (blood + resuscitation fluid) was measured. Results Compared with the control group, direct and immediate application of FloSeal was associated with a reduction in the amounts of fluid lost into the abdominal cavity (p < 0.01) (19.2 +/- 1.5 versus 25.1 +/- 1.5 g) and enhanced mean arterial pressure at 5, 20, and 30 minutes after injury (p = 0.02), but neither survival time (p = 0.12) nor percent survival (p = 0.17) differed between treated and control groups. Conclusions: Reductions in fluid loss after liver injury and hemorrhage in FloSeal-treated rats in the absence of additional applied pressure are encouraging, and provide evidence for the ability of FloSeal to reduce blood loss when applied immediately and directly to a bleeding tissue. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil NR 20 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2006 VL 60 IS 2 BP 385 EP 389 DI 10.1097/01.ta.0000204440.48338.79 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 018MF UT WOS:000235767700027 PM 16508500 ER PT J AU Holcomb, JB Stansbury, LG Champion, HR Wade, C Bellamy, RF AF Holcomb, JB Stansbury, LG Champion, HR Wade, C Bellamy, RF TI Understanding combat casualty care statistics SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE combat; casualty; statistics ID UNITED-STATES; TRAUMA; ARMY AB Maintaining good hospital records during military conflicts can provide medical personnel and researchers with feedback to rapidly adjust treatment strategies and improve outcomes. But to convert the resulting raw data into meaningful conclusions requires clear terminology and well thought out equations, utilizing consistent numerators and denominators. Our objective was to arrive at terminology and equations that would produce the best insight into the effectiveness of care at different stages of treatment, either pre or post medical treatment facility care. We first clarified three essential terms: 1) the case fatality rate (CFR) as percentage of fatalities among all wounded; 2) killed in action (KIA) as percentage of immediate deaths among all seriously injured (not returning to duty); and 3) died of wounds (DOW) as percentage of deaths following admission to a medical treatment facility among all seriously injured (not returning to duty). These equations were then applied consistently across data from the WWII, Vietnam and the current Global War on Terrorism. Using this clear set of definitions we used the equations to ask two basic questions: What is the overall lethality of the battlefield? How effective is combat casualty care? To answer these questions with current data, the three services have collaboratively created a joint theater trauma registry (JTTR), cataloging all the serious injuries, procedures, and outcomes for the current war. These definitions and equations, consistently applied to the JTTR, will allow meaningful comparisons and help direct future research and appropriate application of personnel. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Holcomb, JB (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM John.Holcomb@amedd.army.mil NR 26 TC 178 Z9 183 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2006 VL 60 IS 2 BP 397 EP 401 DI 10.1097/01.ta.0000203581.75241.f1 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 018MF UT WOS:000235767700030 PM 16508502 ER PT J AU Fitzgibbon, JE Sagripanti, JL AF Fitzgibbon, JE Sagripanti, JL TI Simultaneous identification of orthopoxviruses and alphaviruses by oligonucleotide macroarray with special emphasis on detection of variola and Venezuelan equine encephalitis viruses SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE smallpox; variola; Venezuelan equine encephalitis; detection; diagnosis ID POLYMERASE CHAIN-REACTION; MONOCLONAL-ANTIBODIES; SMALLPOX VIRUS; PCR; DIFFERENTIATION; POLYMORPHISM; LIGHTCYCLER; ASSAYS; DNA AB The development of a method in macroarray format for the identification of alphaviruses and orthopoxviruses in samples of concern in biodefense is reported. Capture oligonucleotides designed to bind generic members of the orthopox- or alphavirus families and a collection of additional oligonucleotides to bind specifically nucleic acids from five individual alphaviruses, including Venezuelan equine encephalitis, or DNA from each of four orthopoxviruses, including variola virus (VAR) were deposited onto nylon membranes. Hybridization of digoxigenin labeled PCR products to the macroarray produced results easily observable to the naked eye. Multiplex RT-PCR utilizing both orthopox- and alphavirus-generic primers yielded amplification of DNA corresponding to the expected sizes of the orthopoxvirus and alphavirus fragments, respectively. Hybridization of samples to capture oligonucleotides in the macroarray membranes identified correctly generic orthopox- or alphaviral sequences. The hybridizations correctly identified each of the three alphaviruses and two orthopoxviruses tested. We observed cross-hybridization only once (between two alphaviruses) that was less intense than the spots formed by correct hybridization. The macroarray test described below is easy to perform, inexpensive, relatively fast, uncomplicated to interpret, and its end point is read visually without the need of additional equipment. This nucleic acid hybridization assay onto nylon membranes in macroarray format can help in detecting or excluding the presence of threat viruses in environmental samples and appears promising for a variety of biodefense applications. Published by Elsevier B.V. C1 USA, Edgewood Chem Biol Ctr, Microbiol Branch, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Microbiol Branch, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 25 TC 7 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD FEB PY 2006 VL 131 IS 2 BP 160 EP 167 DI 10.1016/j.jviromet.2005.08.007 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 011JN UT WOS:000235264500008 PM 16181687 ER PT J AU Fang, SF Gertner, G Wang, GX Anderson, A AF Fang, SF Gertner, G Wang, GX Anderson, A TI The impact of misclassification in land use maps in the prediction of landscape dynamics SO LANDSCAPE ECOLOGY LA English DT Article DE confusion matrix; forest; land use map; logistic regression; spatial modeling; uncertainty; urban sprawl AB Land use maps are widely used in modeling land use change, urban sprawl, and for other landscape related studies. A misclassification confusion matrix for land use maps is usually provided as a measure of their quality and uncertainty. However, this very important information is rarely considered in land use map based studies, especially in modeling landscape dynamics. Ignoring uncertainty of land use maps may cause models to provide unreliable predictions. This study is an attempt to investigate the impact of the accuracy of land use maps used as input for an urban sprawl model. In the study area, the regional confusion matrix has been localized using a topographical map. Based on the regional and local confusion matrices, several error levels have been defined. The results showed that a localized confusion matrix that reflected the characteristics of the study area had error rates that were much different than the regional confusion matrix. The predictions of the probability of urban sprawl based on the land use maps and defined error levels were quite different. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61824 USA. RP Gertner, G (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 8 TC 23 Z9 24 U1 1 U2 11 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD FEB PY 2006 VL 21 IS 2 BP 233 EP 242 DI 10.1007/s10980-005-1051-7 PG 10 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 019WC UT WOS:000235866400007 ER PT J AU Joseph, KR Ney, JP AF Joseph, KR Ney, JP TI Pediatric multiple sclerosis SO MAYO CLINIC PROCEEDINGS LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Joseph, KR (reprint author), Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. NR 3 TC 1 Z9 1 U1 0 U2 1 PU MAYO CLINIC PROCEEDINGS PI ROCHESTER PA 660 SIEBENS BLDG MAYO CLINIC, ROCHESTER, MN 55905 USA SN 0025-6196 J9 MAYO CLIN PROC JI Mayo Clin. Proc. PD FEB PY 2006 VL 81 IS 2 BP 151 EP 151 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 008VY UT WOS:000235070000001 PM 16471066 ER PT J AU Hagobian, TA Jacobs, KA Subudhi, AW Fattor, JA Rock, PB Muza, SR Fulc, CS Braun, B Grediagin, A Mazzeo, RS Cymerman, A Friedlander, AL AF Hagobian, TA Jacobs, KA Subudhi, AW Fattor, JA Rock, PB Muza, SR Fulc, CS Braun, B Grediagin, A Mazzeo, RS Cymerman, A Friedlander, AL TI Cytokine response at high altitude: Effects of exercise and antioxidants at 4300 m SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE IL-6; TNF-alpha; C-reactive protein; hypoxia; energy deficit ID INTERLEUKIN-6 RESPONSE; STRENUOUS EXERCISE; OXIDATIVE STRESS; SUPPLEMENTATION; HUMANS; ATTENUATE; PEAK AB Purpose: This study tested the hypothesis that antioxidant supplementation would attenuate plasma cytokine (IL-6, tumor necrosis factor (TNF)-alpha). and C-reactive protein (CRP) concentrations at rest and in response to exercise at 4300-m elevation. Methods: A total of 17 recreationally trained men were matched and assigned to an antioxidant (N = 9) or placebo (N = 8) group in a double-blinded fashion. At sea level (SL), energy expenditure was controlled and subjects were weight stable. Then, 3 wk before and throughout high altitude (HA), an antioxidant supplement (10,000 IU beta-carotene. 200 IU alpha-tocopherol acetate, 250 mg ascorbic acid, 50 mu g selenium, 15 mg zinc) or placebo was given twice daily. At HA, energy expenditure increased approximately 750 kcal(.)d(-1) and energy intake decreased approximately 550 kcal(.)d(-1), resulting in a caloric deficit of approximately 1200-1500 kcal(.)d(-1). At SL and HA day 1 (HA1) and day HA 13, subjects exercised at 55% of VO2peak Until they expended approximately 1500 kcal. Blood samples were taken at rest. end of exercise, and 2, 4, and 20 h after exercise. Results: No differences were seen between groups in plasma IL-6. CRP, or TNF-alpha at rest or in response to exercise. For both groups. plasma IL-6 concentration was significantly higher at the end of exercise, 2, 4. and 20 h after exercise at HA1 compared with SL and HA13. Plasma CRP concentration was significantly elevated 20 h postexercise for both groups on HA1 compared to SL and HA13. TNF-alpha did not differ at rest or in response to exercise. Conclusion: Plasma IL-6 and CRP concentrations, were elevated following exercise at high altitude on day 1. and antioxidant supplementation did not attenuate the rise in plasma IL-6 and CRP concentrations associated with hypoxia, exercise. and caloric deficit. C1 VA Palo Alto Hlth Care Syst, GRECC, Palo Alto, CA 94304 USA. Univ Massachusetts, Amherst, MA 01003 USA. Univ Calif Berkeley, Berkeley, CA 94720 USA. Univ Colorado, Colorado Springs, CO 80907 USA. Oklahoma State Univ, Hlth Sci Ctr, Tulsa, OK USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Univ Colorado, Boulder, CO 80309 USA. RP Friedlander, AL (reprint author), VA Palo Alto Hlth Care Syst, GRECC, 182B,Bldg MB2B,3801 Miranda Ave, Palo Alto, CA 94304 USA. EM friedlan@stanford.edu NR 27 TC 28 Z9 33 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD FEB PY 2006 VL 38 IS 2 BP 276 EP 285 DI 10.1249/01.mss.0000188577.63910.51 PG 10 WC Sport Sciences SC Sport Sciences GA 016SY UT WOS:000235641900013 PM 16531896 ER PT J AU Kecskes, LJ Gardiner, DM Woodman, RH Barber, RE Hartwig, KT AF Kecskes, LJ Gardiner, DM Woodman, RH Barber, RE Hartwig, KT TI Severe plastic deformation of nickel-coated aluminum precursor powders at elevated temperatures SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID COMPOSITES; COMBUSTION; NI3AL; AL AB Two nickel (Ni)-coated aluminum (Al) powders were consolidated to full or near-full density by using the equal-channel angular extrusion (ECAE) technique. Mixtures (in at. pct) of 78Al-22Ni (63Al-37Ni in wt pct), hereafter termed Al-22Ni, and of 39Al-61Ni (23Al-77Ni in wt pct), hereafter termed Al-61 Ni, were placed in square-shaped copper (Cu) or Ni casings, sealed, and heated to a uniform temperature. Subsequently, the billets were dropped into the ECAE die and were single-pass extruded. Preheating temperatures ranged from ambient temperature to 700 C. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and microhardness measurements were used to examine the resultant intermetallics. The onset and nature of the transformation from the precursors into the products were further studied by differential thermal analysis. It was found that the preheating temperature affected the transformation of the Ni-coated Al powder into a nickel-aluminide intermetallic. Specifically, samples of Al-22Ni and Al-61Ni, preheated and consolidated below the nominal reaction temperature of Ni and Al, consisted of a cellular Al structure interposed with a Ni boundary layer. The samples preheated and consolidated above this temperature consisted of Al3Ni and Al3Ni2, AlNi, and AlNi3, respectively. In this case, ECAE caused the multiphase structure of the intermetallics to homogenize and disperse; this was more so for 78Al-22Ni than for 39Al-61Ni. It was also found that the use of a Ni vs Cu casing material greatly improved the densification of the powders. Unlike that found with the Cu casing, full densification using a Ni casing was achieved in a single pass. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Dynam Sci Inc, Aberdeen Proving Ground, MD 21005 USA. Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Kecskes, LJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM laszlo.kecskes@us.army.mil RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 19 TC 3 Z9 3 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD FEB PY 2006 VL 37A IS 2 BP 449 EP 457 DI 10.1007/s11661-006-0016-z PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 011VR UT WOS:000235297100016 ER PT J AU Haimovich, B Venkatesan, MM AF Haimovich, B Venkatesan, MM TI Shigella and Salmonella: death as a means of survival SO MICROBES AND INFECTION LA English DT Review DE Shigella; Salmonella; apoptosis; necrosis; macrophages ID MONOCYTE-DERIVED MACROPHAGES; PATHOGENICITY ISLAND 2; III SECRETION SYSTEM; NECROTIC CELL-DEATH; INFECTED MACROPHAGES; DENDRITIC CELLS; INTRACELLULAR SURVIVAL; BACTERIAL VIRULENCE; ACTIN CYTOSKELETON; INDUCED APOPTOSIS AB Shigella and Salmonella kill host cells and trigger inflammatory responses by mechanisms that are not fully understood. The goal of this review is to reevaluate key observations reported over the past 15 years and, whenever possible, to provide a chronological perspective as to how our understanding of the pathways by which Shigella and Salmonella kill host cells has evolved. Published by Elsevier SAS. C1 UMDNJ, RWJMS, Dept Surg, New Brunswick, NJ 08903 USA. UMDNJ, RWJMS, Canc Inst, New Brunswick, NJ 08903 USA. Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD 20910 USA. RP Haimovich, B (reprint author), UMDNJ, RWJMS, Dept Surg, New Brunswick, NJ 08903 USA. EM haimovic@umdnj.edu; Malabi.Venkatesan@na.amedd.army.mil FU NIAID NIH HHS [R03-AI 53202] NR 75 TC 22 Z9 22 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 J9 MICROBES INFECT JI Microbes Infect. PD FEB PY 2006 VL 8 IS 2 BP 568 EP 577 DI 10.1016/j.micinf.2005.08.002 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 018UL UT WOS:000235790200032 PM 16297650 ER PT J AU Dolan, CA Adler, AB AF Dolan, CA Adler, AB TI Military hardiness as a buffer of psychological health on return from deployment SO MILITARY MEDICINE LA English DT Article ID PERSONALITY HARDINESS; SOCIAL SUPPORT; WORK STRESS; PERFORMANCE; APPRAISAL; OPTIMISM; NURSES AB Military hardiness, the context-specific adaptation of psychological hardiness, is explored as it relates to military occupational stressors. It was hypothesized that military hardiness would moderate the effects of deployment stressors on soldier health. In a survey study of 629 U.S. soldiers, deployment stressors, military hardiness, and psychological and physical health were assessed during a peacekeeping deployment. Health was measured again after deployment. Results of moderated regression analyses partially supported the hypotheses; military hardiness moderated the impact of deployment stressors on depression after deployment, after controlling for depression during deployment. Implications for training military hardiness and applications to other occupational settings are discussed. C1 USA, Med Res Unit Europe, Walter Reed Army Inst Res, APO, AE 09042 USA. RP Dolan, CA (reprint author), USA, Med Res Unit Europe, Walter Reed Army Inst Res, APO, AE 09042 USA. NR 44 TC 32 Z9 32 U1 1 U2 8 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2006 VL 171 IS 2 BP 93 EP 98 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 019JW UT WOS:000235832400001 PM 16578974 ER PT J AU Krauss, MR Russell, RK Powers, TE Li, YZ AF Krauss, MR Russell, RK Powers, TE Li, YZ TI Accession standards for attention-deficit/hyperactivity disorder: A survival analysis of military recruits, 1995-2000 SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-College-of-Preventive-Medicine CY FEB 23, 2001 CL Miami, FL SP Amer Coll Prevent Med ID DEFICIT HYPERACTIVITY DISORDER; MEDICATION USE; CHILDREN; ADHD AB A retrospective cohort study was conducted to evaluate the Department of Defense practice of allowing some individuals with a history of attention-deficit/hyperactivity disorder (ADHD) to enter military service (waiving for ADHD). Enlisted recruits who entered active duty with a waiver for academic problems related to ADHD were compared with control subjects who did not reveal health problems before entry, in terms of retention, promotion, and mental health-related outcomes. A total of 539 recruits with a history of ADHD were retained at the same rate as 1,617 control subjects, with no differences in promotion rates, comorbid diagnoses, or mental health-related discharges. On the basis of these findings, the Department of Defense medical accession standards have been changed to allow applicants who reveal a history of ADHD but did not require medication to finish high school or to hold a job for at least 1 year the opportunity to enter active duty without going through the current waiver process. C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RP Krauss, MR (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. OI Li, Yuanzhang/0000-0001-8872-4430 NR 21 TC 4 Z9 4 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2006 VL 171 IS 2 BP 99 EP 102 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 019JW UT WOS:000235832400002 PM 16578975 ER PT J AU Niebuhr, DW Completo, JD Helfer, TM Chandler, DW AF Niebuhr, DW Completo, JD Helfer, TM Chandler, DW TI A comparison of the military entrance processing station screening audiogram with the defense occupational and environmental health readiness system reference audiogram at Fort Sill, Oklahoma, in 2000 SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Conference of the United-States-Army-Center-for-Health-Promotion-and-Preventive-Medicine-F orce-Health-Protection CY AUG 07-11, 2002 CL Albuquerque, NM SP USA Ctr Hlth Promot & Prevent Med Force Hlth Protect ID HEARING; ARMY; AGE AB Background: The Department of Defense Hearing Conservation Program requires that a reference audiogram be performed at initial entry training (IET), before noise exposure. In the Army, only Fort Sill, home of the field artillery, and Fort Benning, home of the infantry, are in compliance. All military applicants receive a screening audiogram at a military entrance processing station (MEPS) to qualify for service. This audiogram does not meet the Defense Occupational and Environmental Health Readiness System-Hearing Conservation (DOEHRS-HC) standard. Nevertheless, it has been proposed that the MEPS screen be used as the reference because of limited resources and time during IET medical in-processing. Methods: A total of 11,816 individual reference audiograms performed at Fort Sill 95th Adjutant General Recruit Reception Center in 2000 were identified in the DOEHRS-HC database. Results of the MEPS screening audiograms were found for 11,311 (96%) of these individuals. The two audiograms were compared by frequency and ear and by using the two Department of Defense criteria for threshold shift. Results: A total of 14.49% (95% confidence interval, 14.48-14.50%) of audiograms using the three-frequency average difference and 23.19% (95% confidence interval, 23.18-23.20%) using the four-frequency difference in either ear demonstrated a threshold shift. The mean difference in intensity between the two audiograms ranged from 5 to 12 dB and varied by frequency and ear, with the greatest differences being seen at 500 and 6,000 kHz and in the left ear, compared with the right ear. The mean threshold level was higher for each frequency in the DOEHRS-HC audiogram, compared with the MEPS audiogram. Conclusions: Approximately 15% of soldiers at Fort Sill in 2000 showed a clinically significant threshold difference between their MEPS screening and the DOEHRS-HC baseline audiogram. Methodological variations in testing and interval noise-induced hearing loss could account for these differences. The results do not support the use of the MEPS screening audiogram. as the reference audiogram. Compliance with the Hearing Conservation Program in the Army would require either improving MEPS testing to DOEHRS-HC standards or performing baseline audiograms at all five IET sites. C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. USA, Ctr Hlth Promot & Prevent Med, Hearing Conservat Program, Aberdeen Proving Ground, MD 21010 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011 NR 17 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2006 VL 171 IS 2 BP 117 EP 121 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JW UT WOS:000235832400006 PM 16578979 ER PT J AU Wallace, R Topper, SM Eilert, RE AF Wallace, R Topper, SM Eilert, RE TI Management of phalangeal neck fractures in children SO MILITARY MEDICINE LA English DT Article ID PROXIMAL PHALANX; HAND AB Outcomes of phalangeal neck fractures among children are not uniformly good. Our purpose was to delineate factors that affect management and outcomes in the treatment of phalangeal neck fractures among children. The management and outcomes of phalangeal neck fractures among children over a consecutive 7-year period at the Denver Children's Hospital are reported. Fifteen children met the criteria for inclusion in the study. The average age was 6 years. Follow-up periods averaged 36 months. Distinct fracture patterns were classified according to the following system: type I, nondisplaced; type II, displaced. Displaced fractures were subdivided according to the fracture geometry, as follows: type IIa, transverse; type IIb, transverse with a proximally directed spike; type IIc, oblique. Fractures classified as type IIa were not reliably stable after closed reduction and immobilization. Delayed operative stabilization led to digital stiffness. The remaining fracture types were well managed with closed reduction, if necessary, and immobilization. Because of the unreliable stability of type IIa fractures, early operative stabilization is recommended. C1 Walter Reed Army Med Ctr, Dept Orthoped Surg, Washington, DC 20307 USA. Colorado Hand Ctr, Dept Orthoped Surg, Colorado Springs, CO 80907 USA. Childrens Hosp, Dept Orthoped Surg, Denver, CO 80246 USA. RP Wallace, R (reprint author), Raymond W Bliss Army Hlth Ctr, Dept Orthoped Surg, Ft Huachuca, AZ 85613 USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2006 VL 171 IS 2 BP 139 EP 141 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 019JW UT WOS:000235832400011 PM 16578984 ER PT J AU Rivers, FM Wertenberger, DH Lindgren, K AF Rivers, FM Wertenberger, DH Lindgren, K TI US Army Professional Filler System nursing personnel: Do they possess competency needed for deployment? SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Nursing Research Day Conference CY APR 18, 2003 CL Univ Tennessee, Chattanooga, TN HO Univ Tennessee ID READINESS AB The objective of this study was to identify the perceived readiness of U.S. Army Professional Filler System personnel in regard to nursing competency and readiness for deployment. A purposive sample of research participants (N=131) from two military treatment facilities assigned to Great Plains Regional Medical Command responded to an electronic Readiness Estimate and Deployability Index (READI). The READI measures self-reported competencies in six dimensions of nursing readiness. Descriptive statistics and one-way analysis of variance were used to analyze the data. Although the research surveyed three levels of nursing skills (registered nurse, licensed practical nurse, and certified nursing assistant), the study results were noted to be quite parallel across the groups. Significant differences were noted throughout the six dimensions of the READI and between the two military treatment facilities in the dimensions of operational nursing competencies and personal and psychological readiness. Findings support the need for a structured core competency tool to provide succinct focused training to ensure deployment readiness. C1 USA, Hlth Clin, APO, AE 09250 USA. Univ Tennessee, Sch Nursing, Chattanooga, TN 37403 USA. RP Rivers, FM (reprint author), USA, Hlth Clin, APO, AE 09250 USA. NR 16 TC 8 Z9 8 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2006 VL 171 IS 2 BP 142 EP 149 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 019JW UT WOS:000235832400012 PM 16578985 ER PT J AU Royaee, AR Mendis, C Das, R Jett, M Yang, DCH AF Royaee, AR Mendis, C Das, R Jett, M Yang, DCH TI Cholera toxin induced gene expression alterations SO MOLECULAR IMMUNOLOGY LA English DT Article DE cholera toxin; gene expression; cAMP; human lymphocytes; monocytes; cDNA microarrays; forskolin; MDL-12; inflammation; immune response ID MUCOSAL ADJUVANT; B-SUBUNIT; CELLS; ENTEROTOXIN; MICROARRAY; INDUCTION; RESPONSES; CREB AB The cholera toxin (CT) is a well-known inducer of cAMP and cAMP regulates gene expression of many genes. However, little is known as to the alterations in gene expression in response to CT. Here the alterations of the expression of 800 selected genes in response to CT were examined using cDNA microarrays. Gene expression alterations in human lymphocytes and monocytes were found after exposure to CT at varying concentrations for different time periods. Over 200 genes showed varying degrees of alterations of expression in CT-treated cells. The CT-induced changes in gene expression were compared by cDNA microarrays under the same conditions to those in response to forskolin, a specific activator of adenylate cyclase, and MDL-12, an irreversible inhibitor of adenylate cyclase. Thirty-five CT-responsive genes were found responded similarly to forskolin but differently to MDL-12. Fourteen CT-responsive genes were affected similarly by MDL-12 but differently by forskolin. Many of these CT responsive genes were involved in immunity, inflammation and oxidative stress. The CT induced responses correlated with those induced by CT subunits. The down regulation of Th1 markers and upregulation of Th2 markers by CT are consistent with the CT induction of Th2 cells. (C) 2005 Elsevier Ltd. All rights reserved. C1 Georgetown Univ, Dept Chem, Washington, DC 20057 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. RP Yang, DCH (reprint author), Georgetown Univ, Dept Chem, 37th,654 Reiss Sci Bldg, Washington, DC 20057 USA. EM yangdc@georgetown.edu RI Yang, David/A-7294-2009 NR 22 TC 8 Z9 9 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD FEB PY 2006 VL 43 IS 6 BP 702 EP 709 DI 10.1016/j.molimm.2005.03.014 PG 8 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 007EV UT WOS:000234952300023 PM 16360015 ER PT J AU Andzelm, J Sloan, J Napadensky, E Mcknight, S Rigby, D AF Andzelm, J Sloan, J Napadensky, E Mcknight, S Rigby, D TI Molecular modeling study of sulfonated SIBS triblock copolymers SO MOLECULAR SIMULATION LA English DT Article DE multiscale modeling; block copolymers; SIBS; diffusion ID DYNAMICS SIMULATIONS; IONOMER MEMBRANES; GLASSY-POLYMERS; TRANSPORT; DIFFUSION; METHANOL; WATER; SYSTEM; SIZE AB An important class of thermoplastic elastomers involves polystyrene and polyisobutylene blocks (SIBS). Sulfonated SIBS Triblock Copolymers (S-SIBS) are of particular interest because of potential applications for fuel cell and textile applications, where breathable, protective clothing is required. We have used multiscale modeling to gain an understanding of the static and dynamic properties of these polymer systems at detailed atomistic levels. Quantum chemistry tools were used to elucidate the bonding of water molecules and sulfonate groups. In addition, molecular dynamics was applied to calculate the polymer density at various levels of sulfonation. The structures of polymer with hydronium ions and also water were studied and the mechanism of water self-diffusion was proposed. It was found that with increase of water content the hydronium ions move further away from sulfonate groups. The self-diffusion coefficients of water were found to reproduce well experimental trends. Two different distributions of sulfonate groups were studied: one blocky and another perfectly dispersed. In the case of the blocky architecture, the water clusters are connected at a lower sulfonation level, leading to increased water diffusion coefficients as compared to the dispersed architecture. C1 Dynam Sci Inc, Aberdeen, MD 21001 USA. USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Accelrys Inc, San Diego, CA 92121 USA. RP Andzelm, J (reprint author), Dynam Sci Inc, Aberdeen, MD 21001 USA. EM jandzelm@arl.army.mil NR 30 TC 6 Z9 6 U1 1 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0892-7022 J9 MOL SIMULAT JI Mol. Simul. PD FEB PY 2006 VL 32 IS 2 BP 163 EP 172 DI 10.1080/08927020600728613 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 056ZX UT WOS:000238565100011 ER PT J AU Brant, WO Dean, RC Lue, TF AF Brant, WO Dean, RC Lue, TF TI Treatment of Peyronie's disease with oral pentoxifylline SO NATURE CLINICAL PRACTICE UROLOGY LA English DT Article DE pentoxifylline; Peyronie's disease; ultrasound ID RADIATION-INDUCED FIBROSIS; NATURAL-HISTORY; VITAMIN-E; TOCOPHEROL; PREVALENCE; PLAQUE; TRIAL AB Background A 51-year-old male presented with a penile deformity without obvious etiology. Physical examination revealed hard plaques in the dorsal and ventral penis. Investigations Physical examination, penile ultrasound. Diagnosis Peyronie's disease. Management Oral pentoxifylline. C1 Univ Calif San Francisco, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Lue, TF (reprint author), Univ Calif San Francisco, Dept Urol, Knuppe Mol Urol Lab, 400 Parnassus Ave,Box 0738, San Francisco, CA 94143 USA. EM tlue@urol.ucsf.edu NR 19 TC 27 Z9 28 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 1743-4270 J9 NAT CLIN PRACT UROL JI Nat. Clin. Pract. Urol. PD FEB PY 2006 VL 3 IS 2 BP 111 EP 115 DI 10.1038/ncpuro0409 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 012MF UT WOS:000235342600014 PM 16470210 ER PT J AU Farman, TT Vandre, RH Pajak, JC Miller, SR Lempicki, A Farman, AG AF Farman, TT Vandre, RH Pajak, JC Miller, SR Lempicki, A Farman, AG TI Effects of scintillator on the detective quantum efficiency (DQE) of a digital imaging system SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY LA English DT Article ID PERFORMANCE; RADIOGRAPHY; MTF AB Objective. To compare the effects of scintillator on the detective quantum efficiency (DQE) of a charge-coupled device (CCD) digital intraoral radiographic system. Study design. Three screens composed of 3 different scintillator materials, namely europium-doped lutetium oxide (Lu(2)O(3):Eu(3+)), transparent optical ceramic (TOC), thallium-doped cesium iodide (Csl:Tl; Csl), and terbium-doped gadolinium oxysulfide (Gd(2)O(2)S:Tb; GOS) were compared, in turn, in combination with a CCD detector having square pixels with height and width dimensions of 19.5 pm. DQE was investigated using the slanted-slit-derived MTF and Surrogate signal-to-noise ratio (SNR) measurements derived from calculations of the mean and standard deviations from the mean pixel values of multiple random patches from various uniform exposures. An Irix x-ray generator operated at 70 kVp and 8 mA, with a nominal focal spot size of 0.7 mm and 2.5 mm Al equivalent filtration, Was used in making all exposures. Results. Using TOC, the peak DQE was 62% at 5 cycles/mm. For Csl, the peak DQE was 22% at 2 cycles/mm. With GOS, the peak DQE was 10% at 1 cycle/mm. Conclusion. Under identical experimental settings, TOC consistently resulted in higher DQE than Csl and commercially available GOS scintillators combined with the same high-resolution solid-state detector. C1 Univ Louisville, Sch Dent, Div Radiol & Imaging Sci, Dept Surg & Hosp Dent, Louisville, KY 40292 USA. USA, Med Res & Mat Command, US Combat Casualty Care Res Program, Ft Detrick, MD USA. ALEM Associates, Boston, MA USA. Radiat Monitoring Devices Inc, Watertown, MA 02172 USA. RP Farman, AG (reprint author), Univ Louisville, Sch Dent, Div Radiol & Imaging Sci, Dept Surg & Hosp Dent, Louisville, KY 40292 USA. EM agfarm01@louisville.edu NR 20 TC 2 Z9 2 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD FEB PY 2006 VL 101 IS 2 BP 221 EP 225 DI 10.1016/j.tripleo.2005.07.032 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 011WL UT WOS:000235299200015 ER PT J AU Tennyson, H Fowler, C Brennan, J AF Tennyson, H Fowler, C Brennan, J TI A rare etiology of bilateral vocal fold paresis: Multinodular goiter SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery CY SEP 19-22, 2004 CL New York, NY SP Amer Acad Otolaryngol Head Neck Surg C1 San Antonio Uniformed Serv Hlth Educ Consortium, Wilford Hall Med Ctr, San Antonio, TX USA. RP Tennyson, H (reprint author), Brooke Army Med Ctr, Dept Otolaryngol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM heath.tennyson@amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD FEB PY 2006 VL 134 IS 2 BP 340 EP 342 DI 10.1016/j.otohns.2004.12.009 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 011UJ UT WOS:000235293600030 PM 16455391 ER PT J AU Kaylie, DM Wittkopf, JE Coppit, T Warren, FM Netterville, JL Jackson, CG AF Kaylie, DM Wittkopf, JE Coppit, T Warren, FM Netterville, JL Jackson, CG TI Revision lateral skull base surgery SO OTOLOGY & NEUROTOLOGY LA English DT Article DE cranial nerve function; revision; skull base; tumors ID SQUAMOUS-CELL CARCINOMA; TEMPORAL BONE; INTRACRANIAL EXTENSION; GLOMUS TUMORS; MANAGEMENT; REGION AB Objective: To describe functional and reconstructive results after revision lateral skull base Surgery with comparison of benign and malignant lesions. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: All patients undergoing revision Surgery for benign and malignant lateral skull base tumors. Interventions: Surgical resection Of recurrent lateral skull base tumors and reconstruction of resulting defects. Main Outcome Measures: Cranial nerve function postoperative complications. Results: Forty operations for recurrent lateral skull base tumors occurred between January 1, 1987, and December 31, 2003, with follow-up of at least I year. Thirty-three operations were for benign lesions, 27 of which were glomus tumors. Seven operations were for malignant tumors. Fifty-eight percent of patients had preoperative cranial nerve deficits (66% of benign tumors and 14% of malignancies). The most common preoperative deficit occurred in the Xth cranial nerve. Postoperative cranial nerve deficits were seen in 95% of patients and Multiple nerve deficits were seen in 75%. The most common postoperative deficits were observed in the IXth and Xth cranial nerves. Thirty-one patients had one previous procedure, six had two previous procedures, and three had three previous procedures. Abdominal fat and temporoparietal fascia were the most common reconstruction materials. There was one case of meningitis, two cerebrospinal fluid leaks, and one pseudomeningocele. There was one recurrent adenoid cystic tumor resulting in death and two partially resected glomus tumors. Subsequent procedures are discussed. Conclusion: Postoperative cranial deficits are more common after revision skull base surgery than after primary surgery. Complete resection without recurrence can be expected for revision skull base surgery. Modern reconstruction techniques reduce major postoperative complications and morbidity from cranial nerve deficits. C1 Vanderbilt Univ, Med Ctr, Otol Grp Vanderbilt, Dept Otolaryngol Head & Neck Surg, Nashville, TN 37203 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kaylie, DM (reprint author), Vanderbilt Univ, Med Ctr, Otol Grp Vanderbilt, Dept Otolaryngol Head & Neck Surg, 300 20th Ave N,Suite 502, Nashville, TN 37203 USA. EM david.kaylie@vanderbilt.edu NR 19 TC 1 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD FEB PY 2006 VL 27 IS 2 BP 225 EP 233 DI 10.1097/01.mao.0000181186.34034.9a PG 9 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 012NR UT WOS:000235346400015 PM 16436994 ER PT J AU Munavalli, S Rohrbaugh, DK Szafraniec, LL Durst, HD AF Munavalli, S Rohrbaugh, DK Szafraniec, LL Durst, HD TI Trifluoromethylthiolation of 1,3-dithiane SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE 1,3-dithiane; 1,3-dithiolane; bis-(trifluoromethyl)disulfide; bis-(propylthio)-methane; free radical; catalyzed cleavage products; (chloromethyl) propyl sulfide; INAPT'-NMR; GC-MS spectral data; lithio-dithiane; trifluoromethylsulfenyl chloride ID NUCLEAR MAGNETIC-RESONANCE; TRIFLUOROMETHYLSULFENYL CHLORIDE; SATURATED HETEROCYCLES; SYNTHETIC APPLICATIONS; CARBONYL-COMPOUNDS; SULFIDES; CHEMISTRY; ALDEHYDES; REAGENTS; SPECTRA AB With a view to synthesize 2-(trifluoromethylthio)-1,3-dithiane (1),1,3-dithiane (2) was reacted in dry pentane at -78 degrees C under dry N-2 with trifluoromethylsulfenyl chloride (3) and was found to furnish the desired compound in poor yields along with ten other compounds. Under similar conditions, 2-lithio-1,3-dithiane on treatment with 2 and bis-(trifluoromethyl) disulfide (4) gave 8.0% and 10.0% yields of 1, respectively. In connection with this study, (cholromethyl) propyl sulfide and bis(propylthio) methane were synthesized. The reaction of the latter with 3 was also investigated. The characterization of the primary compound formed in the reaction of 2 with 3 using the 'INAPT'-NMR and GC-MS, the probable mechanism of the formation of the various compounds and their mass spectral identification are presented in this article. C1 Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), Sci Applicat Int Corp, POB 68,Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. EM shekar.munavalli@us.army.mil NR 68 TC 5 Z9 5 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD FEB PY 2006 VL 181 IS 2 BP 305 EP 324 DI 10.1080/104265090970377 PG 20 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 006UV UT WOS:000234923900007 ER PT J AU Munavalli, S Bashir-Hashemi, A Rohrbaugh, DK Drust, HD AF Munavalli, S Bashir-Hashemi, A Rohrbaugh, DK Drust, HD TI Trifluoromethylthiocubanes and (trifluoromethylthio)cubylcubanes SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE cubane radical; cubanediyne (cubane diradical); cubylcubane; dehydrocubane; free radical catalyzed dimerization; trifluoromethylthiocopper ID TRIFLUOROMETHYLSULFENYL CHLORIDE; CUBANES; REAGENTS; 1,2-DEHYDROCUBANE; CHEMISTRY; ENERGIES; RADICALS; BONDS; CUBYL AB Reaction of trifluoromethylthiocopper with 1,4-diiodo- and 1-bromo-4-iodocubanes furnishes 1-iodo-4-(trifluoromethylthio)- 1-bromo-4-( trifluoromethylthio)-, and 1,4-bis (trifluoromethylthio) cubanes in respectable yields ( Scheme 1). However, the reaction of iodocubane with trifluoromethylthiocopper under identical conditions yields a complex mixture of mono- and di-substituted cubanes and mono- and di-substituted cubylcubanes (Figure 1). The probable mechanism of their formation and mass spectrometric characterization of the title compounds are presented in this article. C1 Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Lake Hopatcong, NJ USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), Sci Applicat Int Corp, POB 68,Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. EM sxmunava@sbccom.apgea.army.mil NR 50 TC 3 Z9 3 U1 0 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD FEB PY 2006 VL 181 IS 2 BP 435 EP 445 DI 10.1080/104265091001281 PG 11 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 006UV UT WOS:000234923900019 ER PT J AU Chung, PW AF Chung, PW TI Theoretical prediction of stress-induced phase transformations of the second kind in graphene SO PHYSICAL REVIEW B LA English DT Article ID MULTIWALLED CARBON NANOTUBES; MECHANICAL RELAXATION; STRAIN-RATE; TEMPERATURE; BUCKMINSTERFULLERENE; DEFORMATIONS; ENERGETICS; GRAPHITE; STRENGTH; DEFECTS AB Simulations of planar graphene undergoing in-plane deformations are found to develop crystal structures different from the usual hexagonal configuration-either monoclinic or nearly orthorhombic-through two different types of solid phase transitions of the second kind. They are achieved through a concerted C-2 rotation similar in appearance to the onset of the Stone-Wales transformation. The key result is the observation of the early rotation in even the smallest primitive cell. In connection to earlier findings on reversibility, the thermodynamic or kinetic character of the rearrangement is found to depend on the macroscopic straining direction. C1 USA, Res Lab, AMSRL, CI,HC, Aberdeen Proving Ground, MD 21005 USA. RP Chung, PW (reprint author), USA, Res Lab, AMSRL, CI,HC, Aberdeen Proving Ground, MD 21005 USA. EM pchung@arl.army.mil NR 36 TC 7 Z9 7 U1 2 U2 9 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD FEB PY 2006 VL 73 IS 7 AR 075433 DI 10.1103/PhysRevB.73.075433 PG 5 WC Physics, Condensed Matter SC Physics GA 017BK UT WOS:000235668900124 ER PT J AU Tatsimo, SJN Tane, P Melissa, J Sondengam, BL Okunji, CO Schuster, BM Iwu, MM Khan, IA AF Tatsimo, SJN Tane, P Melissa, J Sondengam, BL Okunji, CO Schuster, BM Iwu, MM Khan, IA TI Antimicrobial principle from Aframomum longifolius SO PLANTA MEDICA LA English DT Article DE Aframomum longifolius; Zingiberaceae; antimicrobial activity; labdanes; diterpenoids ID ZINGIBERACEAE; DITERPENOIDS; LABDANES AB Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new lab-dane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8 beta(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), together with the known diterpenes labda-8(17),12(E)-diene-15,16-dial (3) and aframodial (4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive. C1 Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. Univ Yaounde, Dept Organ Chem, Yaounde, Cameroon. Univ Dschang, Dept Chem, Dschang, Cameroon. Bioresources Dev & Conservat Programme, Silver Spring, MD USA. Int Ctr Ethnomed & Drug Dev, Nsukka, Nigeria. Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA. RP Khan, IA (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. EM ikhan@olemiss.edu FU FIC NIH HHS [TW 03004] NR 10 TC 5 Z9 5 U1 0 U2 3 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 J9 PLANTA MED JI Planta Med. PD FEB PY 2006 VL 72 IS 2 BP 132 EP 135 DI 10.1055/s-2005-873192 PG 4 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA 015QG UT WOS:000235565300006 PM 16491448 ER PT J AU Andayi, AW Yenesew, A Derese, S Midiwo, JO Gitu, PM Jondiko, OJI Akala, H Liyala, P Wangui, J Waters, NC Heydenreich, M Peter, MG AF Andayi, AW Yenesew, A Derese, S Midiwo, JO Gitu, PM Jondiko, OJI Akala, H Liyala, P Wangui, J Waters, NC Heydenreich, M Peter, MG TI Antiplasmodial flavonoids from Erythrina sacleuxii SO PLANTA MEDICA LA English DT Article ID STEM BARK; ANTIMALARIAL ACTIVITY; ISOFLAVONOIDS; ISOFLAVANONES; ABYSSINICA; AGENTS AB The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'-prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence. C1 Univ Nairobi, Dept Chem, Nairobi, Kenya. Maseno Univ, Dept Chem, Maseno, Kenya. USA, Med Res Unit, APO, AE 09831 USA. Univ Potsdam, Inst Chem, Potsdam, Germany. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke OI Heydenreich, Matthias/0000-0003-1639-4959 NR 15 TC 26 Z9 27 U1 0 U2 2 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 J9 PLANTA MED JI Planta Med. PD FEB PY 2006 VL 72 IS 2 BP 187 EP 189 DI 10.1055/s-2005-873200 PG 3 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA 015QG UT WOS:000235565300016 PM 16491458 ER PT J AU Shah, M Zhu, KM Wu, HY Potter, J AF Shah, M Zhu, KM Wu, HY Potter, J TI Hispanic acculturation and utilization of cervical cancer screening in the US SO PREVENTIVE MEDICINE LA English DT Article DE Hispanics; women; cervical cancer; screening; acculturation ID MEXICAN-AMERICAN WOMEN; PAP-SMEAR; CARE AB Background. Hispanic women have an incidence rate of invasive cervical cancer that is twice as high as that of non-Hispanic White women. Previous investigations have reported that Hispanics are less likely to utilize cancer screening services. Using data from the 2000 National Health Interview Survey, this study examined whether acculturation of Hispanic women was associated with cervical cancer screening. Methods. The subjects included 2307 Hispanic women aged 21-70 who did not have a history of cervical cancer or a hysterectomy. Women were analyzed by acculturation level according to whether or not they ever had a Pap smear and had one in the previous year and previous 3 years. Results. Acculturation levels tended to be inversely correlated with no Pap smear. Compared to lower acculturated women, women who were more acculturated were less likely to never had a Pap smear (OR = 0.86; 95% CI = 0.58-1.27 for moderate acculturated women and OR = 0.51; 95% Cl = 0.29-0.89 for higher acculturated women). Similar results were found for having no Pap smear within the past 3 years (OR = 0.83; 95% Cl = 0.61-1.13 for moderate acculturated women and OR = 0.73-1 95% Cl = 0.49-1.08 for higher acculturated women). Conclusion. The findings show that lower acculturation was associated with the under use of cervical cancer screening and suggest that these women might have barriers in accessing and utilizing Pap smears. (c) 2005 Published by Elsevier Inc. C1 USA, Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Zhu, KM (reprint author), USA, Mil Canc Inst, Walter Reed Army Med Ctr, Bldg 1,Suite E-111,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kangmin.zhu@na.amedd.army.mil NR 10 TC 37 Z9 37 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 J9 PREV MED JI Prev. Med. PD FEB PY 2006 VL 42 IS 2 BP 146 EP 149 DI 10.1016/j.ypmed.2005.10.002 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 016NJ UT WOS:000235626600014 PM 16297444 ER PT J AU Dux, MP Barent, R Sinha, J Gouthro, M Swanson, T Barthuli, A Inan, M Ross, JT Smith, LA Smith, TJ Webb, R Loveless, B Henderson, I Meagher, MM AF Dux, MP Barent, R Sinha, J Gouthro, M Swanson, T Barthuli, A Inan, M Ross, JT Smith, LA Smith, TJ Webb, R Loveless, B Henderson, I Meagher, MM TI Purification and scale-up of a recombinant heavy chain fragment C of botulinum neurotoxin serotype E in Pichia pastoris GS115 SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article DE botulinum; Pichia pastoris; ion-exchange chromatography; hydrophobic charge induction chromatography; homogenized; filtration; recombinant protein; scale-lip ID VACCINE CANDIDATE; TOXIN; FERMENTATION; EFFICACY AB A recombinant C-terminus heavy chain fragment from botulinum neurotoxin serotype E (BoNT/E) is proposed as a vaccine against the serotype E neurotoxin. This fragment, rBoNTE(H-c), was produced intracellular in Pichict pastoris GS115 by a three-step fermentation process, i.e., glycerol batch phase and a glycerol fed-batch phase to achieve high cell densities, followed by a methanol fed-batch induction phase. The rBoNTE(Hc) protein was purified from the soluble fraction of cell lysates using three ion-exchange chromatography steps (SP Sepharose Fast Flow, Q Sepharose Fast Flow, Sp Sepharose High Performance) and polished with a hydrophobic charge induction chromatography step (MEP HyperCel). Method development at the bench scale was achieved using 7380 mL columns and the process was performed at the pilot scale using 0.5-3.1 L columns in preparation for technology transfer to cGMP manufacturing. The purification process resulted in greater than 98% pure rBoNTE(Hc) based on HPLC and yielded up to 1.01 g of rBoNTE(H-c)/kg cells at the bench scale and 580 mg vaccine/kg cells at the pilot scale. N-terminal sequencing showed that the purified rBoNTE(H-c) N-terminus is intact and was found to protect mice against a challenge of 1000 mouse intraperitoneal LD50'S Of BoNT/E. (c) 2005 Elsevier Inc. All rights reserved. C1 Univ Nebraska, Dept Chem Engn, Biol Proc Dev Facil, Lincoln, NE 68588 USA. A CSC Co, LLC, DVC, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Toxicol, Frederick, MD 21702 USA. RP Meagher, MM (reprint author), Univ Nebraska, Dept Chem Engn, Biol Proc Dev Facil, Lincoln, NE 68588 USA. EM mmeagher1@unl.edu RI Inan, Mehmet/D-9890-2012; OI Inan, Mehmet/0000-0003-1806-7927 FU NIAID NIH HHS [1U01 AI 056514-01] NR 20 TC 32 Z9 34 U1 0 U2 17 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-5928 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD FEB PY 2006 VL 45 IS 2 BP 359 EP 367 DI 10.1016/j.pep.2005.08.015 PG 9 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 011DJ UT WOS:000235247700015 PM 16214371 ER PT J AU DeNoble, VJ Mele, PC AF DeNoble, VJ Mele, PC TI Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone SO PSYCHOPHARMACOLOGY LA English DT Article DE nicotine self-administration; FR schedules; noncontingent nicotine infusions; mecamylamine; hexamethonium; naloxone; rats ID FOOD DELIVERY SCHEDULE; SQUIRREL-MONKEYS; FIXED-RATIO; D-AMPHETAMINE; BEHAVIOR; INJECTIONS; STIMULUS; DISCRIMINATION AB The rate and pattern of lever pressing were studied in 18 rats during 24-h sessions in which responding resulted in intravenous infusions of nicotine. There were four indications of the positive reinforcing effect of nicotine: (1) a greater number of lever presses when nicotine was response-contingent compared to when saline was available; (2) a greater number of responses on the lever resulting in an infusion of nicotine than on the control lever; (3) systematic decreases in the number of contingent nicotine infusions when nicotine was delivered noncontingently; and (4) systematic changes in the frequency of lever pressing as a function of dose. Under a fixed ratio 1 (FR 1) schedule, the number of infusions first increased and then decreased as the dose of nicotine was decreased (64, 32, 16, and 8 mu g/kg infusion) and nicotine intake (mg/kg every 24 h) was directly related to the infusion dose. As the FR size was increased from 1 to 6, the number of lever presses increased and the number of infusions (32 mu g/kg) remained stable. At FR values greater than 6, both the number of lever presses and infusions decreased. Presession injections of mecamylamine (0.75, 1.5, and 3.0 mg/kg, s.c.) decreased the number of infusions in a dose-related manner. Presession injections of hexamethonium (1.5 and 3.0 mg/kg, s.c.) or naloxone (0.75, 1.5, and 3.0 mg/kg, s.c.) did not alter the within- or between-session patterns of nicotine self-administration. Under the conditions of the present experiment, nicotine served as an effective reinforcer and the behavior was shown to be sensitive to both FR size and infusion dose. In addition, the results suggest that nicotine self-administration involves central nicotinic receptors and that opioid receptor antagonism has no effect on nicotine's reinforcing effects in rats. C1 Philip Morris Inc, Res Ctr, Behav Pharmacol Lab, Richmond, VA 23284 USA. USA, Med Res & Mat Command, Off Res & Technol Appl, Ft Detrick, MD 21705 USA. RP DeNoble, VJ (reprint author), 5340 Toscana Way,F309, San Diego, CA 92122 USA. EM vjdfly@aol.com; Paul.Mele@AMEDD.ARMY.MIL NR 41 TC 56 Z9 56 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD FEB PY 2006 VL 184 IS 3-4 BP 266 EP 272 DI 10.1007/s00213-005-0054-z PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 013ZE UT WOS:000235447700002 PM 16088413 ER PT J AU De Leon, J Armstrong, SC Cozza, KL AF De Leon, J Armstrong, SC Cozza, KL TI Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP4502C19 SO PSYCHOSOMATICS LA English DT Article ID ULTRARAPID METABOLIZER PHENOTYPE; ADVERSE DRUG-REACTIONS; GENETIC-POLYMORPHISM; CYTOCHROME P4502D6; CYP2D6 POLYMORPHISM; SERUM-LEVELS; PHARMACOKINETICS; ANTIDEPRESSANTS; ANTIPSYCHOTICS; GENOTYPE AB Pharmacogenetics has arrived in clinical psychiatric practice with the FDA approval of the AmpliChip CYP450 Test that genotypes for two cytochrome P450 2D6 (CYP2D6) and 2C19 (CYP2C19) genes. Other pharmacogenetic tests, including those focused on pharmacodynamic genes, are far from ready for clinical application. CYP2D6 is important for the metabolism of many antidepressants and antipsychotics, and CY2C19 is important for some antidepressant metabolism. Poor metabolizers (PMs), lacking the enzyme, account for up to 7% of Caucasians for CYP2D6 and up to 25% of East Asians for CYP2C19. Patients having three or more active CYP2D6 alleles (up to 29% in North Africa and the Middle East), are called CYP2D6 ultrarapid metabolizers (UMs). CYP2D6 phenotypes (particularly PMs) are probably important in patients taking tricyclic antidepressants (TCAs), venlafaxine, typical antipsychotics, and risperidone. The CYP2C19 PM phenotype is probably important in patients taking TCAs and perhaps citalopram, escitalopram, and sertraline. On the basis of the literature and the authors' clinical experience, the authors provide provisional recommendations for identifying and treating CYP2D6 PMs, CYP2C19 PMs, and CYP2D6 UMs. The next few years will determine whether CYP2D6 genotyping is beneficial for patients taking the new drugs aripiprazole, duloxetine, and atomoxetine. Practical recommendations for dealing with laboratories offering CYP2D6 and CYP2C29 genotyping are provided. C1 Univ Kentucky, Mental Hlth Res Ctr, Eastern State Hosp, Lexington, KY 40508 USA. Tual Forest Grove Hosp, Ctr Geriatr Psychiat, Forest Grove, OR USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. Walter Reed Army Med Ctr, Infect Dis Serv, Dept Med, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP De Leon, J (reprint author), Univ Kentucky, Mental Hlth Res Ctr, Eastern State Hosp, 627 W 4th St, Lexington, KY 40508 USA. EM jdeleon@uky.edu RI de Leon, Jose/F-2709-2013 OI de Leon, Jose/0000-0002-7756-2314 NR 61 TC 168 Z9 176 U1 5 U2 15 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD FEB PY 2006 VL 47 IS 1 BP 75 EP 85 DI 10.1176/appi.psy.47.1.75 PG 11 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 997TD UT WOS:000234270000012 PM 16384813 ER PT J AU Linkov, I Satterstrom, FK Kiker, G Seager, TP Bridges, T Gardner, KH Rogers, SH Belluck, DA Meyer, A AF Linkov, I Satterstrom, FK Kiker, G Seager, TP Bridges, T Gardner, KH Rogers, SH Belluck, DA Meyer, A TI Multicriteria decision analysis: A comprehensive decision approach for management of contaminated sediments SO RISK ANALYSIS LA English DT Article DE MCDA; multicriteria decision analysis; risk assessment ID ENVIRONMENTAL-IMPACT ASSESSMENT; ANALYTIC HIERARCHY PROCESS; FISHERIES MANAGEMENT; STAKEHOLDER VALUES; RISK-ASSESSMENT; RIVER SYSTEM; WATER; ALTERNATIVES; OBJECTIVES; CRITERIA AB Contaminated sediments and other sites present a difficult challenge for environmental decisionmakers. They are typically slow to recover or attenuate naturally, may involve multiple regulatory agencies and stakeholder groups, and engender multiple toxicological and ecotoxicological risks. While environmental decision-making strategies over the last several decades have evolved into increasingly more sophisticated, information-intensive, and complex approaches, there remains considerable dissatisfaction among business, industry, and the public with existing management strategies. Consequently, contaminated sediments and materials are the subject of intense technology development, such as beneficial reuse or in situ treatment. However, current decision analysis approaches, such as comparative risk assessment, benefit-cost analysis, and life cycle assessment, do not offer a comprehensive approach for incorporating the varied types of information and multiple stakeholder and public views that must typically be brought to bear when new technologies are under consideration. Alternatively, multicriteria decision analysis (MCDA) offers a scientifically sound decision framework for management of contaminated materials or sites where stakeholder participation is of crucial concern and criteria such as economics, environmental impacts, safety, and risk cannot be easily condensed into simple monetary expressions. This article brings together a multidisciplinary review of existing decision-making approaches at regulatory agencies in the United States and Europe and synthesizes state-of-the-art research in MCDA methods applicable to the assessment of contaminated sediment management technologies. Additionally, it tests an MCDA approach for coupling expert judgment and stakeholder values in a hypothetical contaminated sediments management case study wherein MCDA is used as a tool for testing stakeholder responses to and improving expert assessment of innovative contaminated sediments technologies. C1 Cambridge Environm Inc, Cambridge, MA 02141 USA. Univ Florida, Gainesville, FL 32611 USA. Purdue Univ, W Lafayette, IN 47905 USA. USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Univ New Hampshire, Ctr Contaminated Sediments Res, Durham, NH 03824 USA. USDOT, FHWA, Washington, DC 20590 USA. USA, Corps Engineers, Hazardous Tox & Radioact Waste Ctr Expertise, Omaha, NE 68144 USA. RP Linkov, I (reprint author), Cambridge Environm Inc, 58 Charles St, Cambridge, MA 02141 USA. EM Linkov@cambridgeenvironmental.com RI Gardner, Kevin/A-8064-2011; OI Gardner, Kevin/0000-0002-3848-0674 NR 75 TC 70 Z9 78 U1 3 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD FEB PY 2006 VL 26 IS 1 BP 61 EP 78 DI 10.1111/j.1539-6924.2006.00713.x PG 18 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 014GQ UT WOS:000235468000011 PM 16492181 ER PT J AU King, DA Keil, K AF King, DA Keil, K TI Comparison of standard radiological risk models and using RESRAD to derive generic risk-based area factors for final status surveys SO RISK ANALYSIS LA English DT Article DE area factors; radiological risk; RESRAD AB The RESidual RADioactivity (RESRAD) computer code has been used for years to calculate carcinogenic risk and radiological dose from exposure to radionuclides. The basic ingestion, inhalation, and direct gamma intake equations used by RESRAD, Risk Assessment Guidance for Superfund (RAGS), and the Soil Screening Guidance for Radionuclides (SSG) are similar and can produce similar results, but there are some notable differences. Of particular interest is the fact that RESRAD incorporates sophisticated environmental transport models. Associated environmental parameters allow risk assessors to consider, among other variables, the size (i.e., surface area) of the contaminated zone, a variable not typically addressed quantitatively under the RAGS/SSG paradigm. Considering the similarities between basic RESRAD, RAGS, and SSG intake equations and given the broad acceptance of RESRAD, it stands to reason that RESRAD-derived area factors may be used to supplement RAGS/SSG human health risk calculations. This would allow risk assessors to retrofit existing results or otherwise modify standard RAGS/SSG equations for use in site closeout planning under the Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM), given a key component of the MARSSIM method is the consideration of small areas of elevated activity or "hot spots" through the use of area factors. C1 Sci Applicat Int Corp, Oak Ridge, TN 37831 USA. USA Corps Engineers, Buffalo, NY USA. RP King, DA (reprint author), Sci Applicat Int Corp, 151 Lafayette Dr,POB 2501, Oak Ridge, TN 37831 USA. EM david.a.king@saic.com NR 7 TC 1 Z9 1 U1 2 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD FEB PY 2006 VL 26 IS 1 BP 175 EP 183 DI 10.1111/j.1539-6924.2006.00711.x PG 9 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 014GQ UT WOS:000235468000021 PM 16492191 ER PT J AU Wojner-Alexandrov, AW Martin, S Grotta, JC Alexandrov, AV AF Wojner-Alexandrov, AW Martin, S Grotta, JC Alexandrov, AV TI Stroke emergency response initiative and outcomes utilization study: Baseline community hospital performance data - A need to get serious now! SO STROKE LA English DT Meeting Abstract CT International Stroke Conference CY FEB 16-18, 2006 CL Kissimmee, FL SP Amer Stroke Assoc C1 Arizona State Univ, Phoenix, AZ USA. Barrow Neurol Inst, Phoenix, AZ 85013 USA. USA, Houston, TX USA. Univ Texas, Sch Nursing, Houston, TX USA. Univ Texas, Sch Med, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD FEB PY 2006 VL 37 IS 2 BP 657 EP 657 PG 1 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 005NJ UT WOS:000234829800272 ER PT J AU Evans, LA Morey, AF AF Evans, LA Morey, AF TI Hemostatic agents and tissue glues in urologic injuries and wound healing SO UROLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID LAPAROSCOPIC PARTIAL NEPHRECTOMY; NEPHRON-SPARING SURGERY; FIBRIN ADHESIVE BANDAGE; RENAL STAB WOUNDS; PORCINE MODEL; RETROPUBIC PROSTATECTOMY; LOCAL HEMOSTASIS; RANDOMIZED TRIAL; BOVINE THROMBIN; RAT MODEL AB Although most applications are off-label, tissue sealants and hemostatic agents are being used increasingly across all surgical disciplines. Biosurgical compounds can serve as adjuncts to primary surgical therapy or may assist in managing or preventing surgical complications. In urology, hemostatic agents and tissue sealants are finding increasing roles in managing traumatic and iatrovenic urologic injuries and promoting optimal Wound healing. Among the variety of hemostatic products now available in the United States (Table 1), fibrin sealant and gelatin matrix thrombin are the most widely used biosurgical agents in urologic surgery. This article details the diverse urologic applications of these products for hemostasis, tissue adhesion, and urinary tract sealing. C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM allen.morey@amedd.army.mil NR 83 TC 7 Z9 7 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0094-0143 J9 UROL CLIN N AM JI Urol. Clin. N. Am. PD FEB PY 2006 VL 33 IS 1 BP 1 EP + DI 10.1016/j.ucl.2005.10.004 PG 13 WC Urology & Nephrology SC Urology & Nephrology GA 021KN UT WOS:000235982200003 PM 16488275 ER PT J AU Stepnik, MW Olby, N Thompson, RR Marcellin-Little, DJ AF Stepnik, MW Olby, N Thompson, RR Marcellin-Little, DJ TI Femoral neuropathy in a dog with iliopsoas muscle injury SO VETERINARY SURGERY LA English DT Article ID TRAUMATIC INJURY; ILIACUS HEMATOMA; SECONDARY; THERAPY AB Oblective-To report femoral nerve dysfunction caused by focal iliopsoas muscle injury and treated by performing tenectomy of the muscle insertion. Study Design-Case report. Animals-A 4-year-old, castrated male, English Mastiff. Results-Iliopsoas muscle injury caused femoral nerve deficits and severe pain. Focal injury was not detected by ultrasonography or computed tomography but was visible on magnetic resonance (MRI) images. Tenectomy of the insertion of the iliopsoas muscle relieved signs of pain. Conclusion-Femoral nerve dysfunction may occur with iliopsoas muscle injury. Clinical Relevance-Iliopsoas muscle injury should be considered in patients with hip pain and MRI is a useful test for diagnosis. Tenectomy may be indicated for relief of chronic iliopsoas muscle pain. C1 N Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC 27606 USA. USA, Vet Corps, Lackland AFB, TX USA. Working Dog Vet Serv, US Dept Def, Lackland AFB, TX USA. RP Olby, N (reprint author), N Carolina State Univ, Coll Vet Med, Dept Clin Sci, 4700 Hillsborough St, Raleigh, NC 27606 USA. EM Natasha_olby@ncsu.edu OI Marcellin-Little, Denis/0000-0001-6596-5928 NR 20 TC 12 Z9 12 U1 0 U2 8 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0161-3499 J9 VET SURG JI Vet. Surg. PD FEB PY 2006 VL 35 IS 2 BP 186 EP 190 DI 10.1111/j.1532-950X.2006.00130.X PG 5 WC Veterinary Sciences SC Veterinary Sciences GA 010TF UT WOS:000235220100011 PM 16472299 ER PT J AU Cardo, LJ Rentas, FJ Ketchum, L Salata, J Harman, R Melvin, W Weina, PJ Mendez, J Reddy, H Goodrich, R AF Cardo, LJ Rentas, FJ Ketchum, L Salata, J Harman, R Melvin, W Weina, PJ Mendez, J Reddy, H Goodrich, R TI Pathogen inactivation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light SO VOX SANGUINIS LA English DT Article DE Leishmania donovani infantum; pathogen inactivation; riboflavin; transfusion transmission; ultraviolet light ID OPERATION DESERT-STORM; VISCERAL LEISHMANIASIS; REDUCTION TECHNOLOGY; BLOOD-PRODUCTS; TRANSFUSION; TRANSMISSION; PARASITEMIA; INFECTION; HAMSTERS; TROPICA AB Background and Objectives Leishmania is transmitted by the bite of the phlebotomine sandfly or by transfusion of infected blood products. Leishmaniasis currently poses a significant problem in several parts of the world, and is an emerging problem in others. The Mirasol PRT technology is based on the use of riboflavin and ultraviolet light to generate chemical reactions in the nucleic acids of pathogens, which prevents replication and leads to inactivation. The intent of this study was to examine the ability of the Mirasol PRT System to kill the Leishmania parasite in human plasma and platelet concentrates. Materials and Methods In visceral Leishmaniasis, amastigotes are present in the blood and in the reticuloendothelial system within monocytes. For each unit of plasma or platelets treated, isolated mononuclear cells obtained from 100 ml of normal donor whole blood were incubated with 1.0 x 10(8)Leishmania donovani infantum promastigotes to produce amastigote-laden macrophages. The infected macrophages were added to 250 ml of human plasma or to 250 ml of platelet concentrates. Infected units were cultured pretreatment in 10-fold serial dilutions to determine the limits of detection. Thirty millilitres of 500 mu m riboflavin was added to each unit, which was then illuminated with 5.9 J/cm(2) of ultraviolet light (6.24 J/ml). After treatment and after 2 months of frozen storage, plasma units were cultured in 10-fold serial dilutions. Platelets were cultured on the day of treatment and on day 5 of storage post-illumination. Result: A 5 log reduction of Leishmania was demonstrated in five of six units of plasma, and a 7 log reduction of Leishmania was demonstrated in one plasma unit. A 5 log reduction of Leishmania was demonstrated in five of six units of platelets, and a 6 log reduction of Leishmania was demonstrated in one unit. Conclusions There is no donor screen for Leishmania and other pathogens constantly emerging in our blood supply. The Mirasol PRT System for Platelets and Plasma is an effective means of killing Leishmania and other emerging pathogens in these blood products. C1 Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Leishmania Diagnost Lab, Silver Spring, MD USA. Navigant Biotechnol, Lakewood, CO USA. RP Cardo, LJ (reprint author), Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, 503 Robert Grant Ave,1N80, Silver Spring, MD 20910 USA. EM lisa.cardo@us.army.mil RI Weina, Peter/A-2120-2011 NR 37 TC 68 Z9 73 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0042-9007 J9 VOX SANG JI Vox Sang. PD FEB PY 2006 VL 90 IS 2 BP 85 EP 91 DI 10.1111/j.1423-0410.2005.00736.x PG 7 WC Hematology SC Hematology GA 005CW UT WOS:000234801200002 PM 16430665 ER PT J AU Burton, DT Turley, SD Fisher, DJ Green, DJ Shedd, TR AF Burton, DT Turley, SD Fisher, DJ Green, DJ Shedd, TR TI Bioaccumulation of total mercury and monomethylmercury in the earthworm Eisenia fetida SO WATER AIR AND SOIL POLLUTION LA English DT Article DE BAF; bioaccumulation; bioaccumulation factor; earthworm; ecological risk assessment; Eisenia fetida; mercury; monomethylmercury; soil ID DUTCH FIELD SOILS; METAL ACCUMULATION; LUMBRICUS-RUBELLUS; HEAVY-METALS; BIOAVAILABILITY; EXPOSURE; CADMIUM; BIOCONCENTRATION; AVAILABILITY; OLIGOCHAETA AB Bioaccumulation factors (BAFs) for inorganic mercury in earthworms are usually < 1; however, factors up to similar to 10 have been reported. Little information is available concerning the bioaccumulation of organic mercury in earthworms from actual contaminated soils and thus there has been uncertainty in the risk characterization phase of ecological risk assessments of mercury-contaminated sites. This study was initiated to determine the rate of uptake and bioaccumulation of total mercury (T-Hg) and monomethylmercury (MMHg) in Eisenia fetida from soils which have been contaminated with mercury for approximately 30 years. The study consisted of a 28-day uptake phase in three mercury-contaminated soils and one soil with background concentrations of mercury followed by a 14-day depuration phase in background soil only. Total mercury concentrations in the study soils ranged from 85 to 11,542 mu g kg(-1) dry weight soil; MMHg concentrations ranged from 1.12 to 7.35 mu g kg(-1) dry weight soil. Time to 90% steady states for T-Hg ranged from 36 to 42 days. A steady state did not occur for any of the MMHg exposures during the 42-day study; estimated time to 90% steady state varied from 97 to 192 days. BAFs for T-Hg ranged from 0.6 to 3.3. BAFs for MMHg ranged from 175 to 249. The BAFs for T-Hg and MMHg were larger in earthworms exposed to the lower contaminated soils and smaller in the higher mercury-contaminated soils. The absolute concentrations of T-Hg and MMHg bioaccumulated in E. fetida, however, were higher in the earthworms exposed to the higher mercury soils and lower in the less mercury-contaminated soils. C1 Univ Maryland, Wye Res & Educ Ctr, Queenstown, MD 21658 USA. USA Garrison, Directorate Safety Hlth & Environm, Aberdeen Proving Ground, MD 21010 USA. USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. RP Burton, DT (reprint author), Univ Maryland, Wye Res & Educ Ctr, POB 169, Queenstown, MD 21658 USA. EM dburton@umd.edu NR 42 TC 28 Z9 29 U1 0 U2 22 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD FEB PY 2006 VL 170 IS 1-4 BP 37 EP 54 DI 10.1007/s11270-006-3113-0 PG 18 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 028UR UT WOS:000236514800004 ER PT J AU Jiang, ZG Lu, XCM Nelson, V Yang, XF Pan, WY Chen, RW Lebowitz, MS Almassian, B Tortella, FC Brady, RO Ghanbari, HA AF Jiang, ZG Lu, XCM Nelson, V Yang, XF Pan, WY Chen, RW Lebowitz, MS Almassian, B Tortella, FC Brady, RO Ghanbari, HA TI A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE hypoglycemia/hypoxia; neuroprotection; PAN-811/Triapine; oxidative; calcium ID RIBONUCLEOTIDE REDUCTASE INHIBITOR; TRANSIENT FOCAL ISCHEMIA; CEREBRAL-ISCHEMIA; IN-VITRO; NEUROPROTECTIVE EFFICACY; MOLECULAR DIVERSITY; NEURONAL DEATH; CA2+ CHANNELS; RAT MODEL; PHASE-I AB Cellular and molecular pathways underlying ischemic neurotoxicity are multifaceted and complex. Although many potentially neuroprotective agents have been investigated, the simplicity of their protective mechanisms has often resulted in insufficient clinical utility. We describe a previously uncharacterized class of potent neuroprotective compounds, represented by PAN-811, that effectively block both ischemic and hypoxic neurotoxicity. PAN-811 disrupts neurotoxic pathways by at least two modes of action. It causes a reduction of intracellular-free calcium as well as free radical scavenging resulting in a significant decrease in necrotic and apoptotic cell death. in a rat model of ischemic stroke, administration of PAN-811 i.c.v. 1 h after middle cerebral artery occlusion resulted in a 59% reduction in the volume of infarction. Human trials of PAN-811 for an unrelated indication have established a favorable safety and pharmacodynamic profile within the dose range required for neuroprotection warranting its clinical trial as a neuroprotective drug. C1 Panacea Pharmaceut Inc, Gaithersburg, MD 20877 USA. Walter Reed Army Inst Res, Div Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. NINDS, Dev & Metab Neurol Branch, NIH, Bethesda, MD 20892 USA. RP Jiang, ZG (reprint author), Panacea Pharmaceut Inc, Gaithersburg, MD 20877 USA. EM zgjiang@panaceapharma.com FU NINDS NIH HHS [R43 NS048694-01, R43 NS048694, 1R43 NS 048694-01] NR 29 TC 22 Z9 23 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 31 PY 2006 VL 103 IS 5 BP 1581 EP 1586 DI 10.1073/pnas.0510573103 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 009EO UT WOS:000235094300076 PM 16423893 ER PT J AU Thoma, DP Moran, MS Bryant, R Rahman, M Holifield-Collins, CD Skirvin, S Sano, EE Slocum, K AF Thoma, DP Moran, MS Bryant, R Rahman, M Holifield-Collins, CD Skirvin, S Sano, EE Slocum, K TI Comparison of four models to determine surface soil moisture from C-band radar imagery in a sparsely vegetated semiarid landscape SO WATER RESOURCES RESEARCH LA English DT Article ID INTEGRAL-EQUATION MODEL; SAR DATA; ROUGHNESS; BACKSCATTER; CALIBRATION; SCATTERING; RANGELAND; EMISSION AB [1] Four approaches for deriving estimates of near-surface soil moisture from radar imagery in a semiarid, sparsely vegetated rangeland were evaluated against in situ measurements of soil moisture. The approaches were based on empirical, physical, semiempirical, and image difference techniques. The empirical approach involved simple linear regression of radar backscatter on soil moisture, while the integral equation method (IEM) model was used in both the physical and semiempirical approaches. The image difference or delta index approach is a new technique presented here for the first time. In all cases, spatial averaging to the watershed scale improved agreement with observed soil moisture. In the empirical approach, variation in radar backscatter explained 85% of the variation in observed soil moisture at the watershed scale. For the physical and best semiempirical adjustment to the physical model, the root-mean-square errors (RMSE) between modeled and observed soil moisture were 0.13 and 0.04, respectively. Practical limitations to obtaining surface roughness measurements limit IEM utility for large areas. The purely image-based delta index has significant operational advantage in soil moisture estimates for broad areas. Additionally, satellite observations of backscatter used in the delta index indicated an approximate 1:1 relationship with soil moisture that explained 91% of the variability, with RMSE = 0.03. Results showed that the delta index is scaled to the range in observed soil moisture and may provide a purely image based model. It should be tested in other watersheds to determine if it implicitly accounts for surface roughness, topography, and vegetation. These are parameters that are difficult to measure over large areas, and may influence the delta index. C1 ARS, USDA, SW Watershed Res Ctr, Tucson, AZ 85719 USA. EMBRAPA, CPAC, BR-73301970 Planaltina, Brazil. USA, Engineer Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Thoma, DP (reprint author), ARS, USDA, SW Watershed Res Ctr, 2000 E Allen Rd, Tucson, AZ 85719 USA. EM dthoma@tucson.ars.ag.gov NR 29 TC 27 Z9 27 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD JAN 31 PY 2006 VL 42 IS 1 AR W01418 DI 10.1029/2004WR003905 PG 12 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 010BS UT WOS:000235159700003 ER PT J AU Pethel, SD Corron, NJ Bollt, E AF Pethel, SD Corron, NJ Bollt, E TI Symbolic dynamics of coupled map lattices SO PHYSICAL REVIEW LETTERS LA English DT Article ID CHAOS AB We present a method to reduce the R-N dynamics of coupled map lattices (CMLs) of N invertibly coupled unimodal maps to a sequence of N-bit symbols. We claim that the symbolic description is complete and provides for the identification of all fixed points, periodic orbits, and dense orbits as well as an efficient representation for studying pattern formation in CMLs. We give our results for CMLs in terms of symbolic dynamical concepts well known for one-dimensional chaotic maps, including generating partitions, Gray orderings, and kneading sequences. An example utilizing coupled quadratic maps is given. C1 USA, Aviat & Missile Command, AMSRD, AMR WS ST, Redstone Arsenal, AL 35898 USA. Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13699 USA. RP Pethel, SD (reprint author), USA, Aviat & Missile Command, AMSRD, AMR WS ST, Redstone Arsenal, AL 35898 USA. OI Corron, Ned/0000-0002-3232-5024 NR 32 TC 15 Z9 16 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD JAN 27 PY 2006 VL 96 IS 3 AR 034105 DI 10.1103/PhysRevLett.96.034105 PG 4 WC Physics, Multidisciplinary SC Physics GA 007LA UT WOS:000234969300042 PM 16486708 ER PT J AU Byrd, EFC Rice, BM AF Byrd, EFC Rice, BM TI Improved prediction of heats of formation of energetic materials using quantum mechanical calculations SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID SURFACE ELECTROSTATIC POTENTIALS; SOLID-PHASE HEATS; DENSITY; ENTHALPIES; MOLECULES; ENERGIES; ATOMS AB We present simple atom and group-equivalent methods that will convert quantum mechanical energies of molecules to gas phase heats of formation of CHNO systems. In addition, we predict heats of sublimation and vaporization derived from information obtained from the quantum-mechanically calculated electrostatic potential of each isolated molecule. The heats of sublimation and vaporization are combined with the aforementioned gas phase heats of fomation to produce completely predicted condensed phase heats of formation. These semiempirical computational methods, calibrated using experimental information, were applied to a series of CHNO molecules for which no experimental information was used in the development of the methods. These methods improve upon an earlier effort of Rice et al. [Rice, B. M.; Pai, S. V.; Hare, J. Combust. Flame 1999, 118, 445] through the use of a larger basis set and the application of group equivalents. The root-mean-square deviation (rms) from experiment for the predicted group-equivalent gas phase heats of formation is 3.2 kcal/mol with a maximum deviation of 6.5 kcal/mol. The rms and maximum deviation of the predicted liquid heats of formation are 3.2 and 7.4 kcal/mol, respectively. Finally, the rms and maximum deviation of predicted solid heats of formation are 5.6 and 12.2 kcal/mol, respectively, an improvement in the rms of approximately 40% compared to the earlier Rice et al. predictions using atom equivalents and a smaller basis set (B3LYP/6-31G*). C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 34 TC 269 Z9 283 U1 11 U2 46 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JAN 26 PY 2006 VL 110 IS 3 BP 1005 EP 1013 DI 10.1021/jp0536192 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 008MY UT WOS:000235046100023 PM 16420001 ER PT J AU Erickson, RP Tripathi, A Maswadeh, WM Snyder, AP Smith, PA AF Erickson, RP Tripathi, A Maswadeh, WM Snyder, AP Smith, PA TI Closed tube sample introduction for gas chromatography-ion mobility spectrometry analysis of water contaminated with a chemical warfare agent surrogate compound SO ANALYTICA CHIMICA ACTA LA English DT Article DE field analysis; gas chromatography; ion mobility spectrometry; solid phase microextraction; resistive heating; chemical warfare agent ID SOLID-PHASE MICROEXTRACTION; FIELD DETECTION; DEGRADATION-PRODUCTS; MASS-SPECTROMETRY; SYSTEM; AEROSOLS; SOIL; BIOMARKER; VX AB Ion mobility spectrometry (IMS) is a proven technology for detection of vapor phase chemical warfare agents. The technology is suitable for field portable instrumentation due to its small size, high sensitivity, speed of analysis, and low power consumption. However, it suffers from a limited dynamic range and potential difficulties in identifying compounds in complex matrices. The use of gas chromatography (GC) coupled to IMS can overcome the difficulty of chemical identification in mixtures by separating the sample into individual components before detection. Using this approach, IMS technology has previously been adapted to detect biological aerosols using an open tube pyrolyzer and a short GC column (Py-GC-IMS). The open sample introduction tube of a Py-GC-IMS instrument would be a convenient configuration to accept aerosol particulates, and while viewed as needed for aerosol trapping, is not optimal for liquid chemical analyses. To examine the usefulness of an existing Py-GC-IMS system for analysis of chemicals in water, an existing open-port sample interface was replaced with a septum-equipped closed tube injector to contain analyte vapors resulting from liquid injection. Tributylphosphate (TBP) was used as a surrogate chemical warfare agent, and aqueous injections into both closed and open tube assemblies were performed. Sample introduction into the closed tube inlet was also accomplished using solid phase microextraction (SPME) preconcentration. The limit of detection for TBP using an open tube, closed tube, and closed tube configuration with SPME sample introduction was 0.980, 0.196, and 0.0098 mg/L respectively. (c) 2005 Elsevier B.V. All rights reserved. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Geocenters Inc, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. USN, Med Ctr San Diego, Ind Hyg Dept, San Diego, CA 92134 USA. RP Smith, PA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM psmith@usuhs.mil RI Smith, Philip/A-6835-2009 OI Smith, Philip/0000-0003-3787-9111 NR 27 TC 23 Z9 25 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD JAN 25 PY 2006 VL 556 IS 2 BP 455 EP 461 DI 10.1016/j.aca.2005.09.031 PG 7 WC Chemistry, Analytical SC Chemistry GA 004CN UT WOS:000234729700027 ER PT J AU Hommerich, U Nyein, E Freeman, JA Amedzake, P Trivedi, SB Zavada, JM AF Hommerich, U Nyein, E Freeman, JA Amedzake, P Trivedi, SB Zavada, JM TI Crystal growth and optical properties of Dy-doped potassium lead bromide (KPb2Br5) SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 16th American Conference on Crystal Growth and Epitaxy/12th US Workshop on Organometallic Vapor Phase Epitaxy* CY JUL 10-OCT 15, 2005 CL Big Sky, MT DE infrared luminescence; rare earth doping; solid-state lasers ID MU-M; KPB2CL5; RBPB2BR5; ND3+ AB Results of the material synthesis and infrared (IR) optical characterization of Dy3+-doped potassium lead bromide (KPb2Br5) are reported. KPb2Br5 was synthesized using commercial PbBr2, and KBr powders and purified through zone refinement in an evacuated quartz ampoule. Following the purification, Dy-doped KPb2Br5 crystals were grown by self-seeded Bridgman technique. The main emission bands of Dy:KPb2Br5 under 800 nm excitation were centered in the near-IR (1.14, 1.33, 1.55, and similar to 1.7 mu m) and mid-IR regions (2.2, 2.4, 2.9, 4.3 mu m). The efficient IR emission from Dy:KPb2Br5 is due to the small maximum phonon energy (similar to 140 cm(-1)) of KPb2Br5, which leads to reduced non-radiative decay rates between excited states of Dy3+ with small energy separation. (c) 2005 Elsevier B.V. All rights reserved. C1 Hampton Univ, Dept Phys, Hampton, VA 23668 USA. Brimrose Corp Amer, Baltimore, MD 21152 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hommerich, U (reprint author), Hampton Univ, Dept Phys, Hampton, VA 23668 USA. EM uwe.hommerich@hamptonu.edu NR 13 TC 14 Z9 15 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD JAN 25 PY 2006 VL 287 IS 2 BP 230 EP 233 DI 10.1016/j.jcrysgro.2005.11.019 PG 4 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 008WO UT WOS:000235071600004 ER PT J AU Santi, L Giritch, A Roy, CJ Marillonnet, S Klimyuk, V Gleba, Y Webb, R Arntzen, CJ Mason, HS AF Santi, L Giritch, A Roy, CJ Marillonnet, S Klimyuk, V Gleba, Y Webb, R Arntzen, CJ Mason, HS TI Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE plague; viral vector; plant biotechnology; recombinant subunit vaccine ID TOBACCO MOSAIC-VIRUS; HETEROLOGOUS PRIME-BOOST; HEAT-LABILE ENTEROTOXIN; V-ANTIGEN; ACTIVE IMMUNIZATION; TRANSGENIC PLANTS; ESCHERICHIA-COLI; PLAGUE IMMUNIZATION; IMMUNE-RESPONSE; EDIBLE VACCINE AB Plague is still an endemic disease in different regions of the world. Increasing reports of incidence, the discovery of antibiotic resistance strains, and concern about a potential use of the causative bacteria Yersinia pestis as an agent of biological warfare have highlighted the need for a safe, efficacious, and rapidly producible vaccine. The use of F1 and V antigens and the derived protein fusion F1-V has shown great potential as a protective vaccine in animal studies. Plants have been extensively studied for the production of pharmaceutical proteins as an inexpensive and scalable alternative to common expression systems. In the current study the recombinant plague antigens F1, V, and fusion protein F1-V were produced by transient expression in Nicotiana benthamiana by using a deconstructed tobacco mosaic virus-based system that allowed very rapid and extremely high levels of expression. All of the plant-derived purified antigens, administered s.c. to guinea pigs, generated systemic immune responses and provided protection against an aerosol challenge of virulent Y. pestis. C1 Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA. Biozentrum Halle, Icon Genet, D-06120 Halle, Saale, Germany. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Arntzen, CJ (reprint author), Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA. EM charles.arntzen@asu.edu; hugh.mason@asu.edu NR 44 TC 92 Z9 106 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 24 PY 2006 VL 103 IS 4 BP 861 EP 866 DI 10.1073/pnas.0510014103 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 007AC UT WOS:000234938300007 PM 16410352 ER PT J AU Han, SY Hite, J Thaler, GT Frazier, RM Abernathy, CR Pearton, SJ Choi, HK Lee, WO Park, YD Zavada, JM Gwilliam, R AF Han, SY Hite, J Thaler, GT Frazier, RM Abernathy, CR Pearton, SJ Choi, HK Lee, WO Park, YD Zavada, JM Gwilliam, R TI Effect of Gd implantation on the structural and magnetic properties of GaN and AlN SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; EARTH-DOPED GAN; VISIBLE EMISSION; ION-BOMBARDMENT; DAMAGE; CATHODOLUMINESCENCE; PHOTOLUMINESCENCE; SURFACE; GROWTH; FILMS AB Gd+ ions were implanted at total doses of 3-6x10(14) cm(2) into single-crystal GaN or AlN epilayers grown on sapphire substrates and annealed at 700-1000 degrees C. The implanted Gd showed no detectable diffusion in either material after annealing, as measured by secondary ion mass spectrometry, corresponding to a diffusion coefficient < 8x10(-12) cm(2) s(-1). Under all annealing conditions, x-ray diffraction shows the formation of second phases. In the case of GaN, these include Gd3Ga2, GdN, and Gd, while for AlN only Gd peaks are observed. Both the GaN and AlN show high saturation magnetization after annealing at 900 degrees C (similar to 15 emu cm(-3) for GaN and similar to 35 emu cm(-3) for AlN). The magnetization versus temperature characteristics of the Gd-implanted GaN show a blocking behavior consistent with the presence of precipitates, whereas the AlN shows a clear difference in field-cooled and zero-field-cooled magnetization to above room temperature which may also be due to Gd inclusions. (c) 2006 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Seoul Natl Univ, Sch Phys, Seoul 151747, South Korea. Seoul Natl Univ, Ctr Strongly Correlated Mat Res, Seoul 151747, South Korea. USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ Surrey, Surrey Ion Beam Ctr, Guildford GU2 7XH, Surrey, England. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Park, Yun/A-9559-2008; Hite, Jennifer/L-5637-2015 OI Park, Yun/0000-0001-7699-0432; Hite, Jennifer/0000-0002-4090-0826 NR 28 TC 47 Z9 47 U1 1 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 23 PY 2006 VL 88 IS 4 AR 042102 DI 10.1063/1.2167790 PG 3 WC Physics, Applied SC Physics GA 007KV UT WOS:000234968600047 ER PT J AU Moores, LK AF Moores, LK TI Diagnosis and management of pulmonary embolism - Are we moving toward an outcome standard? SO ARCHIVES OF INTERNAL MEDICINE LA English DT Editorial Material ID NORMOTENSIVE PATIENTS; D-DIMER C1 Uniformed Serv Univ Hlth Sci, Pulm & Crit Care Med Serv, Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Moores, LK (reprint author), Uniformed Serv Univ Hlth Sci, Pulm & Crit Care Med Serv, Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM Lisa.moores@na.amedd.army.mil NR 9 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JAN 23 PY 2006 VL 166 IS 2 BP 147 EP 148 DI 10.1001/archinte.166.2.147 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 004RH UT WOS:000234769400001 PM 16432080 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI EIS study on the formation of solid electrolyte SO ELECTROCHIMICA ACTA LA English DT Article; Proceedings Paper CT 6th International Symposium on Electrochemical Impedance Spectroscopy CY MAY 16-21, 2004 CL Cocoa Beach, FL DE electrochemical impedance spectroscopy; solid electrolyte interface; ionic conductivity; lithiation; graphite ID LITHIUM-ION BATTERIES; ELECTROCHEMICAL AC-IMPEDANCE; GRAPHITE-ELECTRODES; KINETIC CHARACTERIZATION; VINYLENE CARBONATE; INTERFACE FILM; INTERCALATION; PERFORMANCE; CELL AB Formation of solid electrolyte interface (SEI) on the surface of graphite in Li/graphite cells was studied using the electrochemical impedance spectroscopy (EIS) technique. Results show that EIS of the cells varies considerably with cell voltage. In particular, resistance (R-sei) of the SEI increases significantly with lithiation and decreases reversibly in the subsequent delithiation in a narrow voltage range between 0.15 and 0.04 V. According to the change of the R-sei during the first lithiation process, we might divide the formation of the SEI into two voltage regions: the first region generally occurs above 0.15 V and the second region below 0.15 V. The SEI formed in the first region is less conductive, and that formed in the second region is highly conductive. It is shown that ionic conductivity of the preliminarily formed SEI is greatly affected by the kind of solvents and salts of the electrolyte. We observed that the R-sei increases in the order of LiBF4 > LiSO3CF3 > LiBOB > LiPF6 for salt, and of NMP > EMC > MB for solvent. Addition of vinylene carbonate into the electrolyte results in a significant increase of the R-sei. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 22 TC 186 Z9 199 U1 21 U2 156 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD JAN 20 PY 2006 VL 51 IS 8-9 BP 1636 EP 1640 DI 10.1016/j.electacta.2005.02.137 PG 5 WC Electrochemistry SC Electrochemistry GA 013DV UT WOS:000235390700031 ER PT J AU Jaime-Vasquez, M Martinka, M Groenert, M Dinan, J AF Jaime-Vasquez, M Martinka, M Groenert, M Dinan, J TI Ion scattering and electron spectroscopy of the chemical species at a HF-prepared Si(211) surface SO APPLIED PHYSICS LETTERS LA English DT Article ID SCANNING-TUNNELING-MICROSCOPY; TERMINATED SI(100) SURFACES; MOLECULAR-BEAM EPITAXY; INDEX SI SURFACES; HYDROGEN TERMINATION; SILICON SURFACES; SI(111) SURFACE; RAMAN-SPECTROSCOPY; ETCHING SOLUTIONS; DESORPTION AB The species and the nature of their chemical bonds at the surface of a hydrogen-terminated Si(211) wafer were characterized using temperature desorption spectroscopy, ion scattering spectroscopy, and electron spectroscopy. The surface region is dominated by monohydride species with dihydrides present in small amounts. Fluorine is distributed across the top layer as largely a physisorbed species to the Si substrate. Low-energy He-3(+) ions remove the H and F species with only minimal damage to the underlying region. (c) 2006 American Institute of Physics. C1 USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Jaime-Vasquez, M (reprint author), USA, RDECOM, CERDEC, NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM marvin.jaime@nvl.army.mil NR 37 TC 3 Z9 3 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 16 PY 2006 VL 88 IS 3 AR 031910 DI 10.1063/1.2166682 PG 3 WC Physics, Applied SC Physics GA 004MO UT WOS:000234757100021 ER PT J AU Suchalkin, S Kisin, MV Luryi, S Belenky, G Towner, FJ Bruno, JD Monroy, C Tober, RL AF Suchalkin, S Kisin, MV Luryi, S Belenky, G Towner, FJ Bruno, JD Monroy, C Tober, RL TI Widely tunable type-II interband cascade laser SO APPLIED PHYSICS LETTERS LA English DT Article ID SEMICONDUCTOR-LASERS AB We discuss an ultrawide, voltage-tunable type-II mid-IR interband cascade laser. Its design has a charge accumulation layers outside of the optically active quantum wells that unclamps the electron-hole concentrations and facilitates above-threshold Stark shifts. Our results demonstrate laser tuning of 120 nm (120 cm(-1)). (c) 2006 American Institute of Physics. C1 SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. Max Technol Inc, Hyattsville, MD 20782 USA. Army Res Lab, Adelphi, MD 20873 USA. RP Suchalkin, S (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. EM garik@ece.sunysb.edu NR 9 TC 13 Z9 14 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 16 PY 2006 VL 88 IS 3 AR 031103 DI 10.1063/1.2165289 PG 3 WC Physics, Applied SC Physics GA 004MO UT WOS:000234757100003 ER PT J AU Park, JG Sill, PC Makiyi, EF Garcia-Sosa, AT Millard, CB Schmidt, JJ Pang, YP AF Park, JG Sill, PC Makiyi, EF Garcia-Sosa, AT Millard, CB Schmidt, JJ Pang, YP TI Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE countermeasures; antidotes; protease; zinc protein simulations; structure-based drug design ID PROTON DISSOCIATION-ENERGIES; DYNAMICS SIMULATIONS; POTENT INHIBITORS; SUBSTRATE-SPECIFICITY; INITIO CALCULATIONS; CARBONIC-ANHYDRASE; FORCE-FIELD; DESIGN; TOXIN; LIGANDS AB Botulinum neurotoxin serotype A (BoNTA) is one of the most toxic substances known. Currently, there is no antidote to BoNTA. Small molecules identified from high-throughput screening reportedly inhibit the endopeptidase-the zinc-bound, catalytic domain of BoNTA-at a drug concentration of 20 mu M. However, optimization of these inhibitors is hampered by challenges including the computational evaluation of the ability of a zinc ligand to compete for coordination with nearby residues in the active site of BoNTA. No improved inhibitor of the endopeptidase has been reported. This article reports the development of a serotype-selective, small-molecule inhibitor of BoNTA with a K-i of 12 mu M. This inhibitor was designed to coordinate the zinc ion embedded in the active site of the enzyme for affinity and to interact with a species-specific residue in the active site for selectivity. It is the most potent small-molecule inhibitor of BoNTA reported to date. The results suggest that multiple molecular dynamics simulations using the cationic dummy atom approach are useful to structure-based design of zinc protease inhibitors. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Toxicol & Aerobiol Div, Frederick, MD 21702 USA. Mayo Clin, Coll Med, Comp Aided Mol Design Lab, Rochester, MN 55905 USA. Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Schmidt, JJ (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Toxicol & Aerobiol Div, 1425 Porter St, Frederick, MD 21702 USA. EM james.schmidt@det.amedd.army.mil; pang@mayo.edu OI Pang, Yuan-Ping/0000-0003-0838-2560; Garcia-Sosa, Alfonso T./0000-0003-0542-4446 FU NIAID NIH HHS [2R01 AI 054574-02] NR 68 TC 54 Z9 54 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD JAN 15 PY 2006 VL 14 IS 2 BP 395 EP 408 DI 10.1016/j.bmc.2005.08.018 PG 14 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 995HN UT WOS:000234091500010 PM 16203152 ER PT J AU Knutsen, T Vakulchuk, A Mosijczuk, AD Gabrea, A Ried, T Tretyak, N AF Knutsen, T Vakulchuk, A Mosijczuk, AD Gabrea, A Ried, T Tretyak, N TI Complex rearrangements involving der(8)t(8;20) and der(14)t(8;14)t(11;14), CCND1, and duplication of IgH constant region in acute plasmablastic leukemia SO CANCER GENETICS AND CYTOGENETICS LA English DT Article ID PLASMA-CELL LEUKEMIA; IN-SITU HYBRIDIZATION; MULTIPLE-MYELOMA; ABERRATIONS; INTERPHASE AB We report on a rapidly fatal case of acute plasmablastic leukemia in a 72-year-old male from The Ukraine, who was 70 km away from Chernobyl at the time of the atomic accident in 1986. Spectral karyotyping and fluorescence in situ hybridization (FISH) studies of a bone marrow sample obtained at diagnosis revealed a hypodiploid karyotype with 45 chromosomes and two novel complex rearrangements, der(8)t(8;20)(p11.2;p?12) and der(14)t(8;14)(p?;p11.2)t(11;14)(q13;q32), with juxtaposition of CH (constant region of IgH) sequences to the oncogene CCND1 (translocated to 14q32). FISH analysis demonstrated that the CH on the der(14) was duplicated. (c) 2006 Elsevier Inc. All rights reserved. C1 NCI, Genet Branch, Clin Res Ctr, Bethesda, MD 20892 USA. Inst Hematol & Transfus Med, UA-84060 Kiev, Ukraine. Walter Reed Army Med Ctr, Pediat Hematol Oncol Serv, Washington, DC 20307 USA. Ukraine Acad Med Sci, UA-84060 Kiev, Ukraine. RP Knutsen, T (reprint author), NCI, Genet Branch, Clin Res Ctr, 50 S Dr,Room 1408, Bethesda, MD 20892 USA. EM knutsent@mail.nih.gov NR 14 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0165-4608 J9 CANCER GENET CYTOGEN JI Cancer Genet. Cytogenet. PD JAN 15 PY 2006 VL 164 IS 2 BP 137 EP 141 DI 10.1016/j.cancergencyto.2005.08.027 PG 5 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA 011FU UT WOS:000235254300007 PM 16434317 ER PT J AU Dehqanzada, ZA Storrer, CE Hueman, MT Foley, RJ Harris, K Jama, YH Kao, TC Shriver, CD Ponniah, S Peoples, GE AF Dehqanzada, ZA Storrer, CE Hueman, MT Foley, RJ Harris, K Jama, YH Kao, TC Shriver, CD Ponniah, S Peoples, GE TI Correlations between serum monocyte chemotactic protein-1 levels, clinical prognostic factors, and HER-2/neu vaccine-related immunity in breast cancer patients SO CLINICAL CANCER RESEARCH LA English DT Article ID CHEMOATTRACTANT PROTEIN-1; PROGRESSION; EXPRESSION; TUMOR; CELLS; ANGIOGENESIS; INFLAMMATION; MCP-1 AB Purpose: We studied serum monocyte chemotactic protein-1 (MCP-1) levels in breast cancer patients in relationship to their clinicopathologic variables and immune response to a HER-2/neu E75 vaccine. Experimental Design: We measured MCP-1 levels in 32 HER-2/neu(+) breast cancer patients before and after vaccination with a HER-2/neu E75 peptide + granulocyte macrophage colony-stimulating factor vaccine. Clinical prognostic variables were collected. Vaccine-specific immunologic responses were monitored. Results: Serum MCP-1 levels >250 pg/mL (MCP-high) correlated with favorable prognostic variables. MCP-high patients compared with MCP-low (<250 pg/mL) patients showed statistically significant later onset of disease, earlier stage of disease, fewer nodal metastasis, and less chemotherapy. MCP-high patients had increased levels of preexisting HER-2 immunity when compared with MCP-low patients (69% versus 21%; P = 0.02). However, MCP-low patients showed higher inducible levels of MCP-1 compared with MCP-high patients (median increase, 41% versus 0%; P = 0.001) after vaccination. Moreover, MCP-low patients with >50% increase in MCP-1 levels (response-high) had worse clinical prognostic variables compared with patients with <50% increase (response-low). Response-high patients had statistically significant more poorly differentiated tumors, later stage of disease, and higher percentage of large tumors. Patients with >30% postvaccination MCP-1 increase also showed significant increases in E75-specific CD8(+) T-cells (0.05% versus 0.38%; P = 0.03) in response to vaccination. Conclusions: High serum MCP-1 levels in breast cancer patients correlate with favorable prognostic variables and increased preexisting HER-2/neu immunity. E75 vaccination induces the largest MCP-1 response in patients with unfavorable clinicopathologic variables. Therefore, low serum MCP-1 levels may identify patients with worse prognosis and those most likely to benefit from this vaccination. C1 Uniformed Serv Univ Hlth Sci, Immunol & Res Ctr, Clin Breast Care Project, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Peoples, GE (reprint author), Uniformed Serv Univ Hlth Sci, Immunol & Res Ctr, Clin Breast Care Project, 4301 Jones Bridge Rd,Bldg 139, Bethesda, MD 20814 USA. EM george.peoples@na.amedd.army.mil NR 31 TC 31 Z9 31 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JAN 15 PY 2006 VL 12 IS 2 BP 478 EP 486 DI 10.1158/1078-0432.CCR-05-1425 PG 9 WC Oncology SC Oncology GA 004ZL UT WOS:000234791300024 PM 16428490 ER PT J AU Norton, SA Paris, RM Wonderlich, KJ AF Norton, SA Paris, RM Wonderlich, KJ TI Strange things I have in head": Evidence of prion disease in Shakespeare's Macbeth SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID SPONGIFORM ENCEPHALOPATHY C1 Walter Reed Army Med Ctr, Dermatol Svc, Dept Med, Washington, DC 20307 USA. RP Norton, SA (reprint author), Walter Reed Army Med Ctr, Dermatol Svc, Dept Med, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM scott.norton@na.amedd.army.mil NR 6 TC 3 Z9 3 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2006 VL 42 IS 2 BP 299 EP 302 DI 10.1086/499108 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 993UW UT WOS:000233981800024 PM 16355346 ER PT J AU Zhang, ZJ Lee, YC Kim, SJ Choi, MSS Tsai, PC Xu, Y Xiao, YJ Zhang, P Heffer, A Mukherjee, AB AF Zhang, ZJ Lee, YC Kim, SJ Choi, MSS Tsai, PC Xu, Y Xiao, YJ Zhang, P Heffer, A Mukherjee, AB TI Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL SO HUMAN MOLECULAR GENETICS LA English DT Article ID ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE SYNTHASE; CEROID-LIPOFUSCINOSIS; FATTY ACYLATION; CASPASE-12; INITIATION-FACTOR-2; DEPHOSPHORYLATION; IDENTIFICATION; TRAFFICKING; HUNTINGTIN AB Numerous proteins undergo modification by palmitic acid (S-acylation) for their biological functions including signal transduction, vesicular transport and maintenance of cellular architecture. Although palmitoylation is an essential modification, these proteins must also undergo depalmitoylation for their degradation by lysosomal proteases. Palmitoyl-protein thioesterase-1 (PPT1), a lysosomal enzyme, cleaves thioester linkages in S-acylated proteins and removes palmitate residues facilitating the degradation of these proteins. Thus, inactivating mutations in the PPT1 gene cause infantile neuronal ceroid lipofuscinosis (INCL), a devastating neurodegenerative storage disorder of childhood. Although rapidly progressing brain atrophy is the most dramatic pathological manifestation of INCL, the molecular mechanism(s) remains unclear. Using PPT1-knockout (PPT1-KO) mice that mimic human INCL, we report here that the endoplasmic reticulum (ER) in the brain cells of these mice is structurally abnormal. Further, we demonstrate that the level of growth-associated protein-43 (GAP-43), a palmitoylated neuronal protein, is elevated in the brains of PPT1-KO mice. Moreover, forced expression of GAP-43 in PPT1-deficient cells results in the abnormal accumulation of this protein in the ER. Consistent with these results, we found evidence for the activation of unfolded protein response (UPR) marked by elevated levels of phosphorylated translation initiation factor, eIF2 alpha, increased expression of chaperone proteins such as glucose-regulated protein-78 and activation of caspase-12, a cysteine proteinase in the ER, mediating caspase-3 activation and apoptosis. Our results, for the first time, link PPT1 deficiency with the activation of UPR, apoptosis and neurodegeneration in INCL and identify potential targets for therapeutic intervention in this uniformly fatal disease. C1 NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH, Bethesda, MD 20892 USA. Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Mukherjee, AB (reprint author), NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH, Bethesda, MD 20892 USA. EM mukherja@exchange.nih.gov FU Intramural NIH HHS NR 48 TC 70 Z9 70 U1 1 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0964-6906 J9 HUM MOL GENET JI Hum. Mol. Genet. PD JAN 15 PY 2006 VL 15 IS 2 BP 337 EP 346 DI 10.1093/hmg/ddi451 PG 10 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA 002RZ UT WOS:000234630400015 PM 16368712 ER PT J AU Lastella, S Mallick, G Woo, R Karna, SP Rider, DA Manners, I Jung, YJ Ryu, CY Ajayan, PM AF Lastella, S Mallick, G Woo, R Karna, SP Rider, DA Manners, I Jung, YJ Ryu, CY Ajayan, PM TI Parallel arrays of individually addressable single-walled carbon nanotube field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRICAL BREAKDOWN; ELECTRONIC-STRUCTURE; DEVICES; INTEGRATION; SENSORS; TUBULES AB High-throughput field-effect transistors (FETs) containing over 300 disentangled, high-purity chemical-vapor-deposition-grown single-walled carbon nanotube (SWNT) channels have been fabricated in a three-step process that creates more than 160 individually addressable devices on a single silicon chip. This scheme gives a 96% device yield with output currents averaging 5.4 mA and reaching up to 17 mA at a 300 mV bias. Entirely semiconducting FETs are easily realized by a high current selective destruction of metallic tubes. The excellent dispersity and nearly-defect-free quality of the SWNT channels make these devices also useful for nanoscale chemical and biological sensor applications. (c) 2006 American Institute of Physics. C1 USA, Res Lab, Weapons & Mat Res Directorate, AMSRD,ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. Rensselaer Polytech Inst, Dept Chem, Troy, NY 12180 USA. Dept Mat Sci & Engn, Troy, NY 12180 USA. RP Karna, SP (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, AMSRD,ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. EM skarna@arl.army.mil; ajayan@rpi.edu RI Ryu, Chang/H-1144-2012; Jung, Yung Joon/L-2032-2013; Paquette, Joseph/O-4271-2015 OI Paquette, Joseph/0000-0001-6023-5125 NR 31 TC 27 Z9 27 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 2006 VL 99 IS 2 AR 024302 DI 10.1063/1.2161820 PG 4 WC Physics, Applied SC Physics GA 008BH UT WOS:000235014700066 ER PT J AU Vogler, TJ Reinhart, WD Chhabildas, LC Dandekar, DP AF Vogler, TJ Reinhart, WD Chhabildas, LC Dandekar, DP TI Hugoniot and strength behavior of silicon carbide SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INDUCED PHASE-TRANSITION; SHOCK-WAVE; X-RAY; INELASTIC DEFORMATION; DELAYED FAILURE; CERAMIC TARGETS; SHEAR-STRENGTH; DYNAMIC YIELD; BORON-CARBIDE; COMPRESSION AB The shock behavior of two varieties of the ceramic silicon carbide was investigated through a series of time-resolved plate impact experiments reaching stresses of over 140 GPa. The Hugoniot data obtained are consistent for the two varieties tested as well as with most data from the literature. Through the use of reshock and release configurations, reloading and unloading responses for the material were found. Analysis of these responses provides a measure of the ceramic's strength behavior as quantified by the shear stress and the strength in the Hugoniot state. While previous strength measurements were limited to stresses of 20-25 GPa, measurements were made to 105 GPa in the current study. The initial unloading response is found to be elastic to stresses as high as 105 GPa, the level at which a solid-to-solid phase transformation is observed. While the unloading response lies significantly below the Hugoniot, the reloading response essentially follows it. This differs significantly from previous results for B4C and Al2O3. The strength of the material increases by about 50% at stresses of 50-75 GPa before falling off somewhat as the phase transformation is approached. Thus, the strength behavior of SiC in planar impact experiments could be characterized as metal-like in character. The previously reported phase transformation at similar to 105 GPa was readily detected by the reshock technique, but it initially eluded detection with traditional shock experiments. This illustrates the utility of the reshock technique for identifying phase transformations. The transformation in SiC was found to occur at about 104 GPa with an associated volume change of about 9%. (c) 2006 American Institute of Physics. C1 Sandia Natl Labs, Albuquerque, NM 87185 USA. USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Sandia Natl Labs, POB 5800,MS 1181, Albuquerque, NM 87185 USA. EM tjvogle@sandia.gov RI Vogler, Tracy/B-4489-2009 NR 66 TC 26 Z9 28 U1 7 U2 18 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 2006 VL 99 IS 2 AR 023512 DI 10.1063/1.2159084 PG 15 WC Physics, Applied SC Physics GA 008BH UT WOS:000235014700018 ER PT J AU Whittier, RE Xu, DW van Zanten, JH Kiserow, DJ Roberts, GW AF Whittier, RE Xu, DW van Zanten, JH Kiserow, DJ Roberts, GW TI Viscosity of polystyrene solutions expanded with carbon dioxide SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE carbon dioxide; decahydronaphthalene polystyrene; solution properties; viscosity ID CATALYTIC-HYDROGENATION; CO2-EXPANDED SOLVENTS; SUPERCRITICAL CO2; MOLECULAR-WEIGHT; DEPENDENCE; POLYMERS; TOLUENE AB The viscosity of solutions of polystyrene (PS) in decahydronaphthalene (DHN) was measured in the presence of carbon dioxide (CO,) with a moving-piston viscometer. The effects of the CO, pressure (0-21 MPa), polymer concentration (1-15 wt %), temperature (306-423 K), and polymer molecular weight (126 and 412 kDa) on the viscosity were investigated. In the absence of CO2, the increase in the viscosity with increasing polymer concentration was approximately exponential in concentration and was well described by the Martin equation. All the data fell oil a sin le line when the relative viscosity was plotted against cM(0.50) (where c is the concentration of the polymer ill solution and M is the molecular weight of the polymer). The viscosity of the polymer solution decreased with increasing CO2 pressure under otherwise constant conditions. For a given CO2 pressure, the viscosity reduction was greatest when the relative viscosity was high in the absence of CO2 that is, for high-molecular-weight polymer, high polymer concentrations, and low temperatures. Reductions in the relative viscosity of almost 2 orders of magnitude,were observed in some cases. The viscosity of solutions of PS in DHN also was measured in the presence of sulfur hexafluoride (SF6). At a given pressure, SF6 was about as effective as CO2 in reducing the solution viscosity. (c) 2005 Wiley Periodicals, Inc. C1 N Carolina State Univ, Dept Chem Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Roberts, GW (reprint author), N Carolina State Univ, Dept Chem Engn, Box 7905, Raleigh, NC 27695 USA. EM groberts@ncsu.edu NR 26 TC 7 Z9 9 U1 2 U2 11 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JAN 15 PY 2006 VL 99 IS 2 BP 540 EP 549 DI 10.1002/app.22483 PG 10 WC Polymer Science SC Polymer Science GA 989KQ UT WOS:000233672900013 ER PT J AU Zammarano, M Bellayer, S Gilman, JW Franceschi, M Beyer, FL Harris, RH Meriani, S AF Zammarano, M Bellayer, S Gilman, JW Franceschi, M Beyer, FL Harris, RH Meriani, S TI Delamination of organo-modified layered double hydroxides in polyamide 6 by melt processing SO POLYMER LA English DT Article DE PA6; nanocomposite; LDH ID SILICATE NANOCOMPOSITES; THERMAL-PROPERTIES; POLYMER NANOCOMPOSITES; POLY(ETHYLENE OXIDE); EPOXY NANOCOMPOSITES; CLAY NANOCOMPOSITES; HYDROTALCITE; INTERCALATION; EXFOLIATION; DERIVATIVES AB Layered double hydroxides (LDH) are a class of readily synthesizable layered crystals that can be used as an alternative to the commonly used silicate crystals for the preparation of polymeric nanocomposites. In this work layered double hydroxide/polyamide 6 nanocomposites (LDH/PA6) were prepared from organo-modified LDH by melt processing. The anionic exchange capacity of LDH was varied in order to investigate its influence on the degree of exfoliation. LDH were dispersed by a twin screw micro-extruder at a variety of processing conditions. The nanocomposites were characterized by wide-angle X-ray diffraction (WAXD), small-angle X-ray scattering (SAXS), transmission electron microscopy, dynamic scanning calorimetry, and thermogravimetric analysis. It was found that exfoliated nanocomposites were successfully prepared by melt processing with a low exchange capacity LDH, whereas residue tactoids were observed with a high exchange capacity LDH. Shear, together with the exchange capacity, seems to be the key factor for the delamination in LDH/PA6. No major change in the crystalline phase or in the rate of crystallization was observed in the nanocomposite as compared to the neat polymer. A reduction in the onset of thermal decomposition temperature was observed in PA6/LDH compared to neat PA6, likely due to a nucleophilic attack mechanism. The properties of this nanocomposite system are discussed with connections to the current understanding within the broader nanocomposite field. (c) 2005 Elsevier Ltd. All rights reserved. C1 CimtecLab, I-34012 Trieste, Italy. Natl Inst Stand & Technol, Bldg & Fire Res Lab, Gaithersburg, MD 20899 USA. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. Univ Trieste, Dept Mat Nat Resources, I-34127 Trieste, Italy. RP CimtecLab, Area Sci Pk,Padriciano 99, I-34012 Trieste, Italy. EM zammarano@gmail.com OI Zammarano, Mauro/0000-0002-5145-7110 NR 69 TC 78 Z9 81 U1 1 U2 35 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD JAN 13 PY 2006 VL 47 IS 2 BP 652 EP 662 DI 10.1016/j.polymer.2005.11.080 PG 11 WC Polymer Science SC Polymer Science GA 004TQ UT WOS:000234775600019 ER PT J AU Elabd, YA Napadensky, E Walker, CW Winey, KI AF Elabd, YA Napadensky, E Walker, CW Winey, KI TI Transport properties of sulfonated poly (styrene-b-isobutylene-b-styrene) triblock copolymers at high ion-exchange capacities SO MACROMOLECULES LA English DT Article ID POLYSTYRENE-POLYBUTADIENE-POLYSTYRENE; METHANOL FUEL-CELL; IONOMER MEMBRANES; POLYSTYRENE-BLOCK-POLY(ETHYLENE-RAN-BUTYLENE)-BLOCK-POLYSTYRENE COPOLYMERS; MECHANICAL-PROPERTIES; PROTON CONDUCTIVITY; PHYSICAL-PROPERTIES; BLOCK-COPOLYMERS; PERCOLATION; FILMS AB Transport properties of sulfonated poly(styrene-b-isobutylene-b-styrene) (S-SIBS) triblock copolymers were examined as a function of ion-exchange capacity (IEC), specifically at high IECs (up to similar to 2 mequiv/ g). The proton conductivity of S-SIBS was similar to 1 order of magnitude higher than sulfonated polystyrene at similar IECs and 3-fold higher than Nafion H 7 at an IEC of 2 mequiv/g. However, all polymers in this study possessed similar selectivities (i.e., proton conductivity/methanol permeability) regardless of chemistry or morphology. Small-angle X-ray scattering reveals a periodic-to-nonperiodic transition in S-SIBS with an anisotropic lamellar morphology oriented in the plane of the membrane at IECs ranging from 0.5 to 1 mequiv/g and an isotropic cocontinuous morphology at IECs ranging from 1.1 to 2 mequiv/g. This morphological transition coincides with a discontinuity in the IEC-dependent transport properties. In addition, S-SIBS transport properties were measured after solution casting from 15 different solvents at a constant IEC (0.8 mequiv/g). Transport properties varied by almost 3 orders of magnitude when comparing S-SIBS solution cast from toluene to a toluene/ethanol mixture. X-ray scattering results show morphological differences with solvent choice. This study demonstrates the significant impact of morphology on transport properties in ionic block copolymers. C1 Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. RP Elabd, YA (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM elabd@drexel.edu RI Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 NR 45 TC 120 Z9 120 U1 3 U2 63 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JAN 10 PY 2006 VL 39 IS 1 BP 399 EP 407 DI 10.1021/ma051958n PG 9 WC Polymer Science SC Polymer Science GA 000ZA UT WOS:000234500100058 ER PT J AU Norton, DG Wetzel, ED Vlachos, DG AF Norton, DG Wetzel, ED Vlachos, DG TI Thermal management in catalytic microreactors SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID SYNTHESIS GAS-FORMATION; HYDROGEN-PRODUCTION; PARTIAL OXIDATION; COMBUSTOR/REFORMER MICRODEVICES; HEAT-EXCHANGE; MICRO; MONOLITHS; MIXTURES; SUPPORTS; DESIGN AB In reactors with one or two physical dimensions in the microscale and the remaining dimensions in the mesoscale or macroscale, thermal uniformity is often assumed. However, this assumption is not necessarily correct, especially for well-insulated reactors with fast reaction chemistries. In this paper, a catalytic microreactor with "tunable" wall thermal resistance (conductivity and thickness) is fabricated. Changing the thermal properties of the wall of this reactor is found to have a substantial effect on reactor thermal uniformity but only a slight effect on conversion and extinction limits. Further experiments show that the flow rate and feed composition for this reactor have a large effect on the operating temperature but only a moderate effect on thermal uniformity. An analysis of the overall energy balance of this system indicates that more than 50% of the generated heat is lost to the surroundings before the fluid exits the reactor, although this energy exchange becomes less efficient as the flow rate increases. Computational fluid dynamics simulations suggest that the reaction is limited by heat transfer near the entrance and by mass transfer further downstream, despite the small length scales of this system. C1 Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Aberdeen Proving Ground, MD 21005 USA. RP Vlachos, DG (reprint author), Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. EM vlachos@che.udel.edu OI Vlachos, Dionisios/0000-0002-6795-8403 NR 41 TC 51 Z9 54 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD JAN 4 PY 2006 VL 45 IS 1 BP 76 EP 84 DI 10.1021/ie050674o PG 9 WC Engineering, Chemical SC Engineering GA 998JS UT WOS:000234315400012 ER PT B AU Li, H Bar-Ness, Y Abdi, A Somekh, OS Su, W AF Li, Hong Bar-Ness, Yeheskel Abdi, Ali Somekh, Oren S. Su, Wei GP IEEE TI OFDM modulation classification and parameters extraction SO 2006 1ST INTERNATIONAL CONFERENCE ON COGNITIVE RADIO ORIENTED WIRELESS NETWORKS AND COMMUNICATIONS LA English DT Proceedings Paper CT 1st International Conference on Cognitive Radio Oriented Wireless Networks and Communications CY JUN 08-10, 2006 CL Mykonos Isl, GREECE SP IEEE AB A novel comprehensive classification system is proposed for recognizing the orthogonal frequency division multiplexing (OFDM) signal and extracting its parameters. An empirical distribution function -based Gaussianity test technique is first applied to distinguish OFDM from single carrier modulations. Cyclostationarity and correlation tests are then applied to estimate OFDM symbol duration and cyclic prefix duration. A bank of fast Fourier transform (FFT) bank filter is devised to detect the number of subcarriers. Numerical results are presented to verify the efficiency of the proposed scheme. C1 [Li, Hong; Bar-Ness, Yeheskel; Abdi, Ali; Somekh, Oren S.] New Jersey Inst Technol, Ctr Wireless Commun & Signal Proc Res, ECE Dept, Newark, NJ 07102 USA. [Su, Wei] US Army, RDECOM CERDEC, Ft Monmouth, NJ 07703 USA. RP Li, H (reprint author), New Jersey Inst Technol, Ctr Wireless Commun & Signal Proc Res, ECE Dept, Newark, NJ 07102 USA. EM hl8@njit.edu; yeheskel.barness@njit.edu; ali.abdi@njit.edu; oren.s.somekh@njit.edu NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0380-6 PY 2006 BP 139 EP + PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BGF47 UT WOS:000246440300028 ER PT B AU Gribok, A McKenna, T Reifman, J AF Gribok, Andrei McKenna, Thomas Reifman, Jaques GP IEEE TI Regularization of body core temperature prediction during physical activity SO 2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15 LA English DT Proceedings Paper CT 28th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society CY AUG 30-SEP 03, 2006 CL New York, NY SP IEEE Engn Med & Biol Soc AB This paper deals with the prediction of body core temperature during physical activity in different environmental conditions using first-principles models and data-driven models. We argue that prediction of physiological variables through other correlated physiological variables using data-driven techniques is an ill-posed problem. To make predictions produced by data-driven models accurate and stable they need to be regularized. We demonstrate on data collected during laboratory study that data-driven models, if regularized properly, can outperform first-principles models in terms of accuracy of core temperature predictions. We also show that data-driven models can be made "portable" from one subject to another, thus, making them a valuable, practical tool when data from only one subject is available to "train" the model. C1 [Gribok, Andrei] USA, Med Res & Materiel Command, Telemed & Adv Technol Res Ctr, Frederick, MD 21702 USA. [Gribok, Andrei] Univ Tennessee, Knoxville, TN 37996 USA. [McKenna, Thomas] US Army, Med Res & Mat Command, TeleMed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Reifman, Jaques] US Army, Med Res & Mat Command, Biotechnol & HPC Inst, Ft Detrick, MD 21702 USA. RP Gribok, A (reprint author), USA, Med Res & Materiel Command, Telemed & Adv Technol Res Ctr, Frederick, MD 21702 USA. EM agribok@bioanalysis.org; tmckenna@bioanalysis.org; Jaques.reifman@us.army.mil FU Combat Casualty Care; Military Operational Medicine research programs of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland FX This work was supported, in part, by the Combat Casualty Care and the Military Operational Medicine research programs of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 13 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0032-4 PY 2006 BP 2130 EP + PG 2 WC Engineering, Biomedical SC Engineering GA BGI19 UT WOS:000247284702114 ER PT B AU Venkitasubramaniam, P Tong, L Swami, A AF Venkitasubramaniam, Parvathinathan Tong, Lang Swami, Ananthram GP IEEE TI Score-function quantization for distributed estimation SO 2006 40TH ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS, VOLS 1-4 LA English DT Proceedings Paper CT 40th Annual Conference on Information Sciences and Systems (CISS) CY MAR 22-24, 2006 CL Princeton, NJ SP Princeton Univ, Dept Elect Engn, IEEE Informat Theory Soc ID QUANTIZERS AB We study the problem of quantization for distributed parameter estimation. We propose the design of score-function quantizers to optimize different metrics of estimation performance. Score-function quantizers are a class of quantizers known to maximize the Fisher Information for a fixed value of parameter theta. We show that for distributions that satisfy a monotonicity property, the class of score-function quantizers can be made independent of parameter theta. We then propose a generic algorithm to obtain the optimal Score-function quantizer that can be used to maximize three different metrics; Minimum Fisher Information, Bayesian Fisher Information and Minimum Asymptotic Relative Efficiency. Through numerical examples, we illustrate that these algorithms converge to the optimal quantizers obtained through known algorithms for maximin ARE and Bayesian Fisher Information. C1 [Venkitasubramaniam, Parvathinathan; Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD USA. RP Venkitasubramaniam, P (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM pv45@cornell.edu; lt35@cornell.edu; a.swami@ieee.org FU National Science Foundation [CNS-0435190]; U. S Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement [DAAD19-01-20011] FX This work is supported in part by the National Science Foundation under Contract CNS-0435190. Prepared through collaborative participation in the Communications and Networks Consortium sponsored by the U. S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2 0011. NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 1-4244-0349-9 PY 2006 BP 369 EP 374 DI 10.1109/CISS.2006.286494 PG 6 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Engineering; Imaging Science & Photographic Technology; Telecommunications GA BFU76 UT WOS:000244721800069 ER PT B AU Marvel, LM AF Marvel, Lisa M. GP IEEE TI Q-ary piecewise linear noise modulation SO 2006 40th Annual Conference on Information Sciences and Systems, Vols 1-4 LA English DT Proceedings Paper CT 40th Annual Conference on Information Sciences and Systems (CISS) CY MAR 22-24, 2006 CL Princeton, NJ SP Princeton Univ, Dept Elect Engn, IEEE Informat Theory Soc AB A modulation technique used to embed a message derived from an alphabet of q symbols in a real-valued Gaussian noise sequence is presented. The modulation produces a sequence with a maximum minimum distance property to promote reliable message recovery. This work is an extension of a binary modulation method developed for data hiding using digital images as cover data. Since the modulated sequence possesses Gaussian properties, is typically low power and exposed to noise from the cover, it is difficult for unintended receivers to detect or accurately extract the hidden message. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Marvel, LM (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 1-4244-0349-9 PY 2006 BP 771 EP 771 DI 10.1109/CISS.2006.286570 PG 1 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Engineering; Imaging Science & Photographic Technology; Telecommunications GA BFU76 UT WOS:000244721800145 ER PT B AU Zhao, Q Tong, L Swami, A Chen, YX AF Zhao, Qing Tong, Lang Swami, Ananthram Chen, Yunxia GP IEEE TI Cross-layer design of opportunistic spectrum access in the presence of sensing error SO 2006 40TH ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS, VOLS 1-4 LA English DT Proceedings Paper CT 40th Annual Conference on Information Sciences and Systems (CISS) CY MAR 22-24, 2006 CL Princeton, NJ SP Princeton Univ, Dept Elect Engn, IEEE Informat Theory Soc AB We address the design of cognitive MAC protocols for opportunistic spectrum access in the presence of sensing error. Decentralized protocols are presented for ad hoc networks where there is no central coordinator or dedicated communication/control channel. Secondary users search for and access spectrum opportunities independently without exchanging local information on spectrum availability. We assume on-demand partial spectrum monitoring subject to sensing errors. Specifically, a secondary user may not be able to simultaneously sense the whole spectrum of interest due to hardware limitation and may only monitor the spectrum when it has data to transmit in order to conserve energy. We propose two approaches to formulating opportunistic spectrum access in the presence of sensing error by considering either a constraint on the probability of colliding with primary users or a penalty imposed on each collision. Under these formulations, we address the joint design of both the spectrum sensor at the physical layer and the cognitive protocol at the MAC layer to maximize spectrum efficiency while limiting the interference to primary users. C1 [Zhao, Qing; Chen, Yunxia] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 15853 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Zhao, Q (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM qzhao@ece.ucdavis.edu; ltong@ece.cornell.edu; aswami@arl.army.mil; yxchen@ece.ucdavis.edu FU Army Research Laboratory CTA on Communication and Networks [DAAD19-01-2-0011] FX This work was supported by the Army Research Laboratory CTA on Communication and Networks under Grant DAAD19-01-2-0011. Part of this result was submitted to IEEE Journal on Selected Areas in Communications. NR 28 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 1-4244-0349-9 PY 2006 BP 778 EP 782 DI 10.1109/CISS.2006.286572 PG 5 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Engineering; Imaging Science & Photographic Technology; Telecommunications GA BFU76 UT WOS:000244721800147 ER PT S AU Peck, L Bates, R AF Peck, Lindamae Bates, Richard GP IEEE TI Force Protection Sensor Selector SO 2006: 40TH ANNUAL IEEE INTERNATIONAL CARNAHAN CONFERENCES SECURITY TECHNOLOGY, PROCEEDINGS SE CARNAHAN CONFERENCE ON SECURITY TECHNOLOGY LA English DT Proceedings Paper CT 40th Annual IEEE International Carnahan Conference on Security Technology CY OCT 16-19, 2006 CL Lexington, KY SP IEEE Lexington Sect, IEEE Aerosp & Elect Syst Soc, Chung Shan Inst Sci & Technol, Natl Cent Univ, Sandia Natl Labs, SAIC, Senstar Stellar AB Force Protection Sensor Selector (FPSS) is a computer application that assists security personnel in the selection of exterior intrusion detection systems best suited for maintaining force protection and physical security at a site. The FPSS software ranks intrusion detection system (IDS) suitability on the basis of known environmental impacts on sensor systems and expected operating conditions. The ranking is done both for probability of detection (Pd) and nuisance alarm rate (NAR). C1 [Peck, Lindamae; Bates, Richard] USA, Engineer Res & Dev, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. RP Peck, L (reprint author), USA, Engineer Res & Dev, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. FU Army PM-Force Protection Systems; DOD Physical Security Equipment Action Group FX FPSS was sponsored by the Army PM-Force Protection Systems as ane exploratory development project with DOD Physical Security Equipment Action Group funding. The authors thank Jim Lacombe and David Fisk oF CRREL for helpful technical reviews of this paper. NR 0 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0737-1160 BN 1-4244-0174-7 J9 CAR C SECUR PY 2006 BP 34 EP + DI 10.1109/CCST.2006.313427 PG 2 WC Engineering, Multidisciplinary SC Engineering GA BFO68 UT WOS:000243472000007 ER PT B AU Capponi, A Pilotto, C Farina, A Golino, G Kaplan, L AF Capponi, A. Pilotto, C. Farina, A. Golino, G. Kaplan, L. GP IEEE TI Connectivity for the frisbee architecture SO 2006 9TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION, VOLS 1-4 LA English DT Proceedings Paper CT 9th International Conference on Information Fusion CY JUL 10, 2006 CL Florence, ITALY DE random distributed sensor retworks; self-organization; connectivity threshold; detection range ID GRAPH AB In this paper we investigate the k-connectivity threshold of distributed dense ad hoc heterogeneous wireless sensor network architecture. We consider the situation when sensors are deployed in the surveillance area according to a uniform distribution perturbed by a Gaussian noise. We derive analytically the minimum detection range which guarantees an emerging structure in the network, namely the connectivity, which becomes larger and larger as the number of sensors in the network increase. This allows the target track to be propagated almost surely throughout the network using the minimum possible amount of prime energy. We report the results of some simulation experiments which further support the theoretical results. C1 [Capponi, A.; Pilotto, C.] CALTECH, 1200 E Calif Blvd,MC 256-80, Pasadena, CA 91125 USA. [Farina, A.; Golino, G.] Selex SI, Rome 00131, Italy. [Kaplan, L.] US Army Res Lab, Adelphi, MD 20783 USA. RP Capponi, A (reprint author), CALTECH, 1200 E Calif Blvd,MC 256-80, Pasadena, CA 91125 USA. EM acapponi@cs.caltech.edu; pilotto@cs.caltech.edu; afarina@selex-si.com; ggolino@selex-si.com; lkaplan@ieee.org NR 19 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0953-2 PY 2006 BP 217 EP 223 PG 7 WC Computer Science, Artificial Intelligence SC Computer Science GA BGC32 UT WOS:000245998000030 ER PT B AU Capponi, A Pilotto, C Golino, G Farina, A Kaplan, L AF Capponi, A. Pilotto, C. Golino, G. Farina, A. Kaplan, L. GP IEEE TI Algorithms for the selection of the active sensors in distributed tracking: Comparison between Frisbee and GNS methods SO 2006 9TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION, VOLS 1-4 LA English DT Proceedings Paper CT 9th International Conference on Information Fusion CY JUL 10, 2006 CL Florence, ITALY DE wireless network of sensors; surveillance; distributed target tracking AB This paper compares two different approaches for sensor selection for distributed tracking: 1) The Frisbee method, and 2) Global Node Selection (GNS). The Frisbee method is based on the proximity of the nodes to the predicted location of the target; GNS is based on minimizing the unbiased Cramer Rao lower bound (CRLB). Both theoretical and experimental results indicate that the Frisbee method is as effective as GNS. Furthermore, the Frisbee method is attractive due to its very light computational load. C1 [Capponi, A.; Pilotto, C.] CALTECH, 1200 E Calif Blvd,MC 25680, Pasadena, CA 91125 USA. [Golino, G.; Farina, A.] Selex SI, Rome, Italy. [Kaplan, L.] US Army Res Lab, Adelphi, MD 20783 USA. RP Capponi, A (reprint author), CALTECH, 1200 E Calif Blvd,MC 25680, Pasadena, CA 91125 USA. EM acapponi@cs.caltech.edu; pilotto@cs.caltech.edu; afarina@selex-si.com; ggolino@selex-si.com; lkaplan@ieee.org NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0953-2 PY 2006 BP 232 EP 239 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BGC32 UT WOS:000245998000032 ER PT B AU Powell, GM Matheus, CJ Kokar, MM Lorenz, D AF Powell, Gerald M. Matheus, Christopher J. Kokar, Mieczyslaw M. Lorenz, David GP IEEE TI Understanding the role of context in the interpretation of complex battlespace intelligence SO 2006 9th International Conference on Information Fusion, Vols 1-4 LA English DT Proceedings Paper CT 9th International Conference on Information Fusion CY JUL 10, 2006 CL Florence, ITALY DE automated analysis; battlespace intelligence; context dependency; METT-TC; multi-source fusion AB A key challenge presented by the increasing volume and complexity of information collectable from battlespace situations is the development of intelligent applications able to automatically analyze the information and identify critical enemy activities in a timely manner. What makes this information fusion problem particularly difficult is the strong contextual dependency of the interpretation of complex battlespaee information. This paper examines the dimensions of intelligence information, establishes a framework for exploring the effects of contextual information and provides an illustration of its use. The paper concludes with a discussion of the ramifications of context on the development of intelligent applications intended to aid in the interpretation of complex battlespace intelligence. C1 USA, RDECOM CERDEC 12WD, Ft Monmouth, NJ USA. Northeastern Univ, Boston, MA 02115 USA. Versatile Informat Syst Inc, Framingham, MA USA. EWA Govt Syst Inc, Herndon, VA USA. RP Powell, GM (reprint author), USA, RDECOM CERDEC 12WD, Ft Monmouth, NJ USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0953-2 PY 2006 BP 1134 EP 1141 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BGC32 UT WOS:000245998000159 ER PT B AU Chakraborty, N Hammamieh, R Wang, Y Laing, M Liu, ZG Mulligan, J Jett, M AF Chakraborty, Nabarun Hammamieh, Rasha Wang, Yan Laing, Mark Liu, Zaigang Mulligan, John Jett, Marti GP IEEE TI GeneCite: A tool for PubMed and UniSTS literature mining SO 2006 BIO- MICRO- AND NANOSYSTEMS CONFERENCE LA English DT Proceedings Paper CT Bio- Micro- and Nanosystems Conference CY JAN 15-18, 2006 CL San Francisco, CA C1 [Chakraborty, Nabarun; Hammamieh, Rasha; Wang, Yan; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [Laing, Mark; Liu, Zaigang; Mulligan, John] Syntek Co, Gaithersburg, MD USA. RP Chakraborty, N (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0056-0 PY 2006 BP 50 EP 50 DI 10.1109/BMN.2006.330925 PG 1 WC Nanoscience & Nanotechnology SC Science & Technology - Other Topics GA BGE52 UT WOS:000246328700030 ER PT S AU Capponi, A Kaplan, L Pilotto, C AF Capponi, Agostino Kaplan, Lance Pilotto, Concetta GP IEEE TI Performance characterization of random proximity sensor networks SO 2006 FORTIETH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS, VOLS 1-5 SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 40th Asilomar Conference on Signals, Systems and Computers CY OCT 29-NOV 02, 2006 CL Pacific Grove, CA SP Naval Postgrad Sch, ATK Mission Res, IEEE Signal Proc Soc AB In this paper, we characterize the localization performance and connectivity of sensors networks consisting of binary proximity sensors using a random sensor management strategy. The sensors are deployed uniformly at random over an area, and to limit the energy dissipation, each sensor node switches between an active and idle state according to random mechanisms regulated by a birth-and-death stochastic process. We first develop an upper bound for the minimum transmitting range which guarantees connectivity of the active nodes in the network with a desired probability. Then, we derive an analytical formula for predicting the mean-squared localization error of the active nodes when assuming a centroid localization scheme. Simulations are used to verify the theoretical claims for various localization schemes that operate only over connected active nodes. C1 [Capponi, Agostino; Pilotto, Concetta] CALTECH, Dept Comp Sci, Pasadena, CA 91125 USA. [Kaplan, Lance] US Army Res Lab, Adelphi, MD 20783 USA. RP Capponi, A (reprint author), CALTECH, Dept Comp Sci, Pasadena, CA 91125 USA. EM acapponi@cs.caltech.edu; lkaplan@ieee.org; pilotto@cs.caltech.edu NR 9 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4244-0784-2 J9 CONF REC ASILOMAR C PY 2006 BP 493 EP + DI 10.1109/ACSSC.2006.354796 PG 2 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Engineering; Imaging Science & Photographic Technology; Telecommunications GA BGH15 UT WOS:000246925201013 ER PT S AU Chen, YX Zhao, Q Swami, A AF Chen, Yunxia Zhao, Qing Swami, Ananthram GP IEEE TI Joint design and separation principle for opportunistic spectrum access SO 2006 FORTIETH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS, VOLS 1-5 SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 40th Asilomar Conference on Signals, Systems and Computers CY OCT 29-NOV 02, 2006 CL Pacific Grove, CA SP Naval Postgrad Sch, ATK Mission Res, IEEE Signal Proc Soc AB This paper develops optimal strategy for opportunistic spectrum access (OSA) by integrating the design of spectrum sensor at the physical layer with that of spectrum sensing and access policies at the medium access control (MAC) layer. The design objective is to maximize the throughput of secondary users while limiting their probability of colliding with primary users. By exploiting the rich structures of the problem, we establish a separation principle: the design of spectrum sensor and access policy can be decoupled from that of sensing policy without losing optimality. This separation principle enables us to obtain closed-form optimal sensor operating characteristic and access policy, leading to significant complexity reduction. It also allows us to study the inherent interaction between spectrum sensor and access policy and the tradeoff between false alarm and miss detection in opportunity identification. C1 [Chen, Yunxia; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 94536 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, YX (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 94536 USA. EM yxchen@ece.ucdavis.edu; qzhao@ece.ucdavis.edu; aswami@arl.army.mil FU Army Research Laboratory CTA on Communication and Networks [DAAD19-01-2-0011]; National Science Foundation [CNS-0627090, ECS-0622200] FX Manuscript received February 27, 2007; revised January 17, 2008. This work was supported in part by the Army Research Laboratory CTA on Communication and Networks under Grant DAAD19-01-2-0011 and by the National Science Foundation under Grants CNS-0627090 and ECS-0622200. The material in this paper was presented in part at the IEEE Asilomar Conference on Signal, Systems, and Computers, Asilomar, CA, October/ November 2006 and the IEEE Workshop on Signal Processing Advances in Wireless Communications, Helsinki, Finland, June 2007. NR 10 TC 7 Z9 7 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4244-0784-2 J9 CONF REC ASILOMAR C PY 2006 BP 696 EP + PG 2 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Engineering; Imaging Science & Photographic Technology; Telecommunications GA BGH15 UT WOS:000246925201052 ER PT S AU Satorius, E Wu, YW LaRocca, B Kosinski, J AF Satorius, Edgar Wu, Ying-Wah LaRocca, Brian Kosinski, John GP IEEE TI Implementation of polyphase channelizers for multirate signal analysis SO 2006 FORTIETH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS, VOLS 1-5 SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 40th Asilomar Conference on Signals, Systems and Computers CY OCT 29-NOV 02, 2006 CL Pacific Grove, CA SP Naval Postgrad Sch, ATK Mission Res, IEEE Signal Proc Soc ID CONVOLUTION AB Polyphase discrete-Fourier transform (DFT) filter banks are used in a wide variety of applications involving the channelization and analysis of multi-component signals. Of particular interest are oversampled architectures that enable high-fidelity demodulation and signal processing of channelized signals. In this paper, we examine architectures of polyphase DFT filter banks that are suitable for field programmable gate array (FPGA) implementation and discuss implementation issues that arise in high speed, realtime applications. C1 [Satorius, Edgar] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. [Wu, Ying-Wah; LaRocca, Brian; Kosinski, John] US Army, I2WD, Ft Monmouth, NJ 07703 USA. RP Satorius, E (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. EM satorius@jpl.nasa.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4244-0784-2 J9 CONF REC ASILOMAR C PY 2006 BP 1170 EP + DI 10.1109/ACSSC.2006.354939 PG 2 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Engineering; Imaging Science & Photographic Technology; Telecommunications GA BGH15 UT WOS:000246925202060 ER PT S AU Ramprashad, SA Pepin, C Kozat, UC AF Ramprashad, Sean A. Pepin, Christine Kozat, Ulas C. GP IEEE TI Distortion tradeoffs of different layered speech and media transmission techniques over wireless MIMO systems SO 2006 FORTIETH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS, VOLS 1-5 SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 40th Asilomar Conference on Signals, Systems and Computers CY OCT 29-NOV 02, 2006 CL Pacific Grove, CA SP Naval Postgrad Sch, ATK Mission Res, IEEE Signal Proc Soc AB The paper presents an analysis of strategies that combine layered source coding with various transmission strategies over point-to-point multiple input multiple output (MIMO) wireless systems. We are interested in the potential benefits/tadeoffs such systems have for the transmission of media. In doing so the paper necessarily considers two main issues. The first is to describe a measure/framework that can be used to generally guide the assessment of media (source) quality in the presence of outage events. The measure presented relates to traditional metrics but allows for more careful consideration of outage events. This allows for a more realistic assessment of the net media quality. Having such a measure is central to the MIMO investigation. The second issue is the optimization of media transport over wireless MIMO. With transmission systems one can explore with media (unlike data) the tradeoffs between media quality, the attempted transmission rate and the probability of outage events. With MIMO in particular we can consider adding diversity options enabled by layered source descriptions. The results suggest that MIMO transmission strategies that add diversity (linked to the source) can show benefits to media quality when compared to some media agnostic MIMO strategies that focus only on capacity. C1 [Ramprashad, Sean A.; Pepin, Christine; Kozat, Ulas C.] USA, DoCoMo Commun Labs, San Jose, CA 95110 USA. RP Ramprashad, SA (reprint author), USA, DoCoMo Commun Labs, San Jose, CA 95110 USA. EM ramprashad@docomolabs-usa.com; pepin@docomolabs-usa.com; kozat@docomolabs-usa.com NR 13 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4244-0784-2 J9 CONF REC ASILOMAR C PY 2006 BP 1308 EP + PG 2 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Engineering; Imaging Science & Photographic Technology; Telecommunications GA BGH15 UT WOS:000246925202086 ER PT S AU Torrieri, D Mathur, A Mukherjee, A Kwon, HM AF Torrieri, Don Mathur, Avinash Mukherjee, Amitav Kwon, Hyuck M. GP IEEE TI Iterative EM estimation based LDPC CDMA receiver SO 2006 FORTIETH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS, VOLS 1-5 SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 40th Asilomar Conference on Signals, Systems and Computers CY OCT 29-NOV 02, 2006 CL Pacific Grove, CA SP Naval Postgrad Sch, ATK Mission Res, IEEE Signal Proc Soc DE EM Algorithm; iterative receiver; LDPC AB This paper proposes a scheme of iteratively obtaining an estimate of channel coefficient and noise power spectral density (PSD), initially with the aid of pilot symbols. The iterative receiver employs a low-density parity-check (LDPC) code and channel estimation based on expectation maximization. Pilot bits are distributed among subframes followed by spreading and binary phase-shift keying. At the receiver, an initial estimate of channel coefficient and noise PSD is obtained using pilot information. Subsequent values of channel coefficient and noise PSD are both iteratively updated by the soft feedback from the LDPC decoder. The updated channel coefficient and noise PSD are iteratively passed to the LDPC decoder, which results in an improved decoding accuracy, as shown. C1 [Torrieri, Don] Army Res Lab, Adelphi, MD 20783 USA. [Mathur, Avinash; Mukherjee, Amitav; Kwon, Hyuck M.] Wichita State Univ, Dept Elect & Comp Engn, Wichita, KS 67260 USA. RP Torrieri, D (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM dtorrieri@arl.army.mil; axmathur@wichita.edu; axmukherjee@wichita.edu; hyuck.kwon@wichita.edu RI Mukherjee, Amitav/A-7336-2009 NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4244-0784-2 J9 CONF REC ASILOMAR C PY 2006 BP 2219 EP + PG 2 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology; Telecommunications SC Engineering; Imaging Science & Photographic Technology; Telecommunications GA BGH15 UT WOS:000246925204070 ER PT S AU Haldemann, AFC Johnson, JB Elphic, RC Boynton, WV Wetzel, J AF Haldemann, Albert F. C. Johnson, Jerome B. Elphic, Richard C. Boynton, William V. Wetzel, John GP IEEE TI Construction and resource utilization eXplorer (CRUX): Implementing instrument suite data fusion to characterize regolith hydrogen resources SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT ID LUNAR POLES; SOLAR-WIND; WATER ICE; MOON; DEPOSITS; MERCURY AB CRUX is a modular suite of geophysical and borehole instruments combined with display and decision support system (Mapper/DSS) tools to characterize regolith resources, surface conditions, and geotechnical properties. CRUX is a NASA-funded Technology Maturation Program effort to provide enabling technology for Lunar and Planetary Surface Operations (LPSO) [1]. The Mapper/DSS uses data fusion methods with CRUX instruments, and other available data and models, to provide regolith properties information needed for LPSO that cannot be determined otherwise. We demonstrate the data fusion method by showing how it might be applied to characterize the distribution and form of hydrogen using a selection of CRUX instruments: Borehole Neutron Probe and Thermal Evolved Gas Analyzer data as a function of depth help interpret Surface Neutron Probe data to generate 3D information. Secondary information from other instruments along with physical models improves the hydrogen distribution characterization, enabling information products for operational decision-making(1,2). C1 [Haldemann, Albert F. C.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr,MS 238-420, Pasadena, CA 91109 USA. [Johnson, Jerome B.] USA ERDC, CRREL, Waiwright, AK 99703 USA. [Elphic, Richard C.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Boynton, William V.] Univ Arizona, Lunar & Planetary Lab, Tucson, AZ 85721 USA. [Wetzel, John] Appl Res Associates, South Royalton, VT 05068 USA. RP Haldemann, AFC (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr,MS 238-420, Pasadena, CA 91109 USA. EM albert.f.haldemann@jpl.nasa.gov; Jerome.B.Johnson@erdc.usace.army.mil; relphic@lanl.gov; wboynton@lpl.arizona.edu; jwetzel@ara.com NR 11 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 217 EP + PG 3 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583100020 ER PT S AU Albert, DG Banerdt, WB AF Albert, Donald G. Banerdt, W. Bruce GP IEEE TI A seismic profiler for the construction and resource utilization explorer (CRUX) SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT AB A modular integrated suite of instruments and software known as the Construction Resource Utilization eXplorer (CRUX) is being developed for the U.S. National Aeronautics and Space Administration (NASA) to provide semiautonomous reconnaissance of the lunar and planetary surfaces [1]. One component of the CRUX, the seismic profiler (SEIP) instrument, is described in this paper. The hardware is described and examples of synthetic and real (Earth) seismic data are presented and discussed. Because of the advances in the electronic hardware and digital analysis methods that have occurred since the Apollo lunar missions, this instrument will have the flexibility to gather and analyze seismic data in a number of different ways to enhance the usefulness of the seismic information. C1 [Albert, Donald G.] USA, ERDC CRREL, 72Lyme Rd, Hanover, NH 03755 USA. [Banerdt, W. Bruce] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. RP Albert, DG (reprint author), USA, ERDC CRREL, 72Lyme Rd, Hanover, NH 03755 USA. EM Donald.G.Albert@erdc.usace.army.mil; Bruce.Banerdt@jpl.nasa.gov NR 18 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 381 EP + PG 2 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583100035 ER PT S AU Kim, SS Carnes, SR Haldemann, AF Ulmer, CT Ng, EHW Arcone, SA AF Kim, Soon Sam Carnes, Steven R. Haldemann, Albert F. Ulmer, Christopher T. Ng, Eddie Ho Wah Arcone, Steven A. GP IEEE TI Miniature ground penetrating radar, CRUX GPR SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT AB Under NASA instrument development programs (PIDDP 2000-2002, MIDP 2003-2005, ESR&T, 2005), we have been developing miniature ground penetrating radars (GPR) for use in mapping subsurface stratigraphy from planetary rovers for Mars and lunar applications. 1,2 The Mars GPR is for deeper penetration (up to 50-m depth) into the Martian subsurface at moderate resolution (1.5 m) for a geological characterization. As a part of the CRUX (Construction & Resource Utilization Explorer) instrument suite, the CRUX GPR is optimized for a lunar prospecting application. It will have shallower penetration (5-m depth) with higher resolution (15 cm.) for construction operations including ISRU (in-situ resource utilization). The GPR is a short-pulse type system, which responds to interfaces between materials of differing dielectric permittivity. C1 [Kim, Soon Sam; Carnes, Steven R.; Haldemann, Albert F.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. [Ng, Eddie Ho Wah] Star Technol Inc, Los Angeles, CA 90012 USA. [Ulmer, Christopher T.] Ulmer Syst Inc, Pasadena, CA 91106 USA. [Arcone, Steven A.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Kim, SS (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. EM Soonsam.Kim@jpl.nasa.gov; Steven.R.Carnes@jpl.nasa.gov; Albert.F.Haldemann@jpl.nasa.gov; ulmerbooks@yahoo.com; eddie_ng_2003@yahoo.com; Steven.A.Arcone@erdc.usace.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 387 EP + PG 3 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583100036 ER PT S AU Rock, JC AF Rock, Janice C. GP IEEE TI Semiconductor substrates in phased arrays - Integration issues, challenges and laboratory results SO 2006 IEEE Aerospace Conference, Vols 1-9 SE IEEE AEROSPACE CONFERENCE PROCEEDINGS LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT AB This paper will discuss the ongoing research being conducted in the RF Technology Division of the Applied Sensors, Guidance, and Electronics Directorate, US Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC) on the Redstone Arsenal in Huntsville, Alabama. The overall purpose of the research is to determine and overcome the technological barriers impinging upon enhancements to current phased array technology which is expected to include MEMS in addition to chip-level integration of multiple phased array components. An overview of phased array systems and components will be presented along with applications and insertion into potential military systems and the benefits thereof. The paper will discuss the current research effort and future research areas for this project and its benefits in creating an air defense system to support the Future Combat System (FCS) of the US Arrny. C1 USA, Aviat & Missile Res Dev & Engn Ctr, AMSAM RD MG RF, Redstone Arsenal, AL 35898 USA. RP Rock, JC (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr, AMSAM RD MG RF, Redstone Arsenal, AL 35898 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 959 EP 971 PG 13 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583101034 ER PT S AU Booth, JP Brown, S AF Booth, Joel P. Brown, Stephanie GP IEEE TI Electromagnetic study of multilayer medial SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT AB This paper will discuss a basic electromagnetic analysis of multilayer material used in a radome application. The purpose of this work is to investigate a possible new configuration for a missile seeker. The discussion will be based on computer simulations with real world applications. This effort is being conducted in the RF Technology Division of the Applied Sensors, Guidance, and Electronics Directorate in conjunction with End Game Analysis, collocated at the US Army Aviation and Missile Command, Aviation and Missile Research, Development, and Engineering Center (AMRDEC) on the Redstone Arsenal in Huntsville, Alabama. The ground work for this effort was covered in a graduate class at the University of Alabama in Huntsville under the instruction of Dr. John Jarem. This research is a continuation of that work. C1 [Booth, Joel P.; Brown, Stephanie] USA, Aviat & Missile Res Dev & Engn Ctr, AMSRD AMR SG RF, Redstone Arsenal, AL 35898 USA. RP Booth, JP (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr, AMSRD AMR SG RF, Redstone Arsenal, AL 35898 USA. EM Joel.booth@rdec.redstone.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 972 EP + PG 3 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583101035 ER PT S AU Weiss, S Dahlstrom, R AF Weiss, Steven Dahlstrom, Robert GP IEEE TI Rotman Lens development at the Army Research Lab SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT AB An electronic scanning antenna (ESA) that uses a beamformer for scanning the beam has the advantage of being able to form multiple beams for multimode, shared-aperture applications. This scanning approach is achieved at a reduced parts count for the antenna subassembly and therefore at a lower cost than approaches utilizing phase-shifting elements for controlling the beam. This paper discusses our efforts to realize such a beamformer using Rotman lens geometry and details some of the technologies we investigated as well as some engineering trade-offs encountered. C1 [Weiss, Steven; Dahlstrom, Robert] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Weiss, S (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sweiss@arl.army-mil; dahlstrom@arl.army-mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 1093 EP + PG 3 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583101048 ER PT S AU Kaplan, LM Blair, WD Bar-Shalom, Y AF Kaplan, Lance M. Blair, William Dale Bar-Shalom, Yaakov GP IEEE TI Simulations studies of multisensor track association and fusion methods SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT DE track-to-track association; likelihood ratio tests; sensor fusion; data association; target tracking AB Recent work has developed maximum likelihood (ML) methods for track-to-track data association and fusion in a multisensor, i.e., more than two sensor, environment. In order to conserve bandwidth, only the state estimates and corresponding covariance matrices are shared amongst the nodes. The fusion engine uses this track information to determine which tracks associate to the same target and then computes a fused track to improve the accuracy of the state estimates. The simplest class of ML methods assume that the track errors from different sensors are uncorrelated. The more computationally demanding ML methods incorporate the cross-correlations that are due to the common process noise in the kinematic model of the target. In order to account for track correlations in practice, the cross-covariance matrices must be approximated from the single sensor covariance matrices. This paper introduces new methods to approximate the cross-covariance matrices, and these approximations lead to a third class of association and estimation methods. The paper then uses simulations to assess the performance of the different association and estimation techniques. The simulations include results when the sensor tracks are produced by either a Kalman filter or an interacting multiple model (IMM) filter. C1 [Kaplan, Lance M.] Army Res Lab, Adelphi, MD 20783 USA. [Blair, William Dale] Georgia Tech Res Inst, Smyrna, GA 30080 USA. [Bar-Shalom, Yaakov] Univ Connecticut, Storrs, CT 06269 USA. RP Kaplan, LM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 2004 EP + PG 4 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583103036 ER PT S AU Fadiran, OO Molnar, P Kaplan, LM AF Fadiran, Oladipo O. Molnar, Peter Kaplan, Lance M. GP IEEE TI A statistical approach to quantifying clutter in hyperspectral infrared images SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT DE clutter complexity; hyperspectral imagery; factor analysis AB A method to quantify clutter in hyperspectral infrared (HSI) images in a framework similar to work done on single-band images is presented. Hereby, all objects in a scene that may be mistaken for targets by an Automatic Target Recognition (ATR) algorithm are considered clutter. A hyperspectral image contains a number of contiguous discrete bands within the spectrum. The aim is to obtain a measure of complexity for hyperspectral images, which will indicate the inherent difficulty for an ATR to detect targets. We implemented 129 different image clutter metrics, and computed them for a database of synthesized HSI images. A matched filter ATR was used to determine the amount of clutter in the images as a baseline. We developed a method to select a subset of the metrics that in combination correlated best with the amount of clutter in an image, and defined this as the clutter complexity measure (CCM). Multiple runs of this selection procedure for different training image groups show a dominance of a further subset of metrics that best predict the CCM. Our results also show that the CCM obtained from a varying number of random sample images generalizes well for the entire database. C1 [Fadiran, Oladipo O.] Clark Atlanta Univ, Ctr Theoret Study Phys Syst, 223 James P Brawley Dr Sw, Atlanta, GA 30141 USA. [Molnar, Peter] Clark Atlanta Univ, Dept Comp & Informat Sci, Atlanta, GA 30141 USA. [Kaplan, Lance M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Fadiran, OO (reprint author), Clark Atlanta Univ, Ctr Theoret Study Phys Syst, 223 James P Brawley Dr Sw, Atlanta, GA 30141 USA. EM ofadiran@ieee.org; pmolnar@ieee.org; lkaplan@ieee.org FU ARO MURI [G-41-Z93-G4] FX This work was supported by an ARO MURI under award No.G-41-Z93-G4. NR 17 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 2186 EP + PG 3 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583103053 ER PT S AU Le, Q Kaplan, LM McClellan, JH AF Le, Qiang Kaplan, Lance M. McClellan, James H. GP IEEE TI Multiobjective energy-aware node selection SO 2006 IEEE AEROSPACE CONFERENCE, VOLS 1-9 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2006 IEEE Aerospace Conference CY MAR 04-11, 2006 CL Big Sky, MT ID WIRELESS MICROSENSOR NETWORKS AB This work develops a resource management strategy for a wireless sensor network of bearings-only sensors. Specifically, the resource manager determines which nodes actively sense and communicate during each snapshot in order to achieve a tolerable level of geolocalization accuracy while attempting to maximize the effective lifetime of the network. Unlike other methods that use the total energy consumed for the given snapshot as an energy-based metric, a new energy-based (EB) metric can achieve load balancing of the nodes without resorting, to computationally demanding non-myopic optimization. Simulation results show that EB provides longer lifetime than an existing geometry-based (GB) metric. We consider an adaptive transmission range control based upon the remaining battery level and the physical location knowledge of nodes in the network. The activation decision is performed in a decentralized manner over the active set of nodes. Each active node transmits just far enough to reach all the active nodes for information sharing and the potentially active nodes for information handoff. In determining the active set, both global and local approaches are considered. The global approach assumes each node knows the physical location of every other node in the network. On the other hand, the local approach assumes that a node only knows the location of itself, the previous active set, and neighboring nodes. C1 [Le, Qiang; McClellan, James H.] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Kaplan, Lance M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Le, Q (reprint author), Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. FU U.S. Army Research Labpoworatory under Cooperative Agreement [DAAD19-O1-2-008] FX Prepared through collaborative participation in the Advanced Sensors Collaborative Technology Alliance sponsored by the U.S. Army Research Labpoworatory under Cooperative Agreement DAAD19-O1-2-008. The U. S. Goveminment is authorized to reproduce and distribute reprints for Government purposes not with standing any copyright notation thereon NR 13 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 0-7803-9545-X J9 AEROSP CONF PROC PY 2006 BP 2342 EP + PG 4 WC Engineering, Aerospace SC Engineering GA BFF34 UT WOS:000241583104011 ER PT S AU Holguin, LM AF Holguin, Lionel M., Jr. GP IEEE TI Aviation and missile research development and engineering center SO 2006 IEEE AUTOTESTCON, VOLS 1 AND 2 SE IEEE Autotestcon LA English DT Proceedings Paper CT 41st Annual Autotestcon Conference CY SEP 18-21, 2006 CL Anaheim, CA SP IEEE C1 USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Holguin, LM (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr, Bldg 5400 Fowler Rd, Redstone Arsenal, AL 35898 USA. EM lionel.holguin@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-0051-5 J9 IEEE AUTOTESTCON PY 2006 BP 392 EP 397 PG 6 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA BGI04 UT WOS:000247088200062 ER PT B AU Feiler, PH Lewis, BA Vestal, S AF Feiler, Peter H. Lewis, Bruce A. Vestal, Steve GP IEEE TI The SAE architecture analysis & design language (AADL) A standard for engineering performance critical systems SO 2006 IEEE CONFERENCE ON COMPUTER-AIDED CONTROL SYSTEM DESIGN, VOLS 1 AND 2 LA English DT Proceedings Paper CT IEEE Conference on Computer-Aided Control System Design CY OCT 04-06, 2006 CL Munich, GHANA SP IEEE AB The Society of Automotive Engineers (SAE) Architecture Analysis & Design Language, AS5506, provides a means for the formal specification of the hardware and software architecture of embedded computer systems and system of systems. It was designed to support a full Model Based Development fifecycle including system specification, analysis, system tuning, integration, and upgrade over the lifecycle. It was designed to support the integration of multiple forms of analyses and to be extensible in a standard way for additional analysis approaches. A system can be automatically integrated from AADL models when fully specified and when source code is provided for the software components. Analysis of large complex systems has been demonstrated in the avionics domain. C1 Inst Software Engn, Pittsburgh, PA 15213 USA. USA, AMRDEC, Huntsville, AL 35898 USA. RP Feiler, PH (reprint author), Inst Software Engn, Pittsburgh, PA 15213 USA. EM bruce.a.lewis@us.army.mil NR 26 TC 0 Z9 0 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7803-9797-2 PY 2006 BP 302 EP 307 PG 6 WC Automation & Control Systems; Computer Science, Interdisciplinary Applications SC Automation & Control Systems; Computer Science GA BFZ01 UT WOS:000245516300049 ER PT B AU Buennemeyer, TK Jacoby, GA Chiang, WG Marchany, RC Tront, JG AF Buennemeyer, Timothy K. Jacoby, Grant A. Chiang, Wayne G. Marchany, Randolph C. Tront, Joseph G. GP IEEE TI Battery-sensing intrusion protection system SO 2006 IEEE INFORMATION ASSURANCE WORKSHOP LA English DT Proceedings Paper CT 7th Annual IEEE Information Assurance Workshop CY JUN 21-23, 2006 CL W Point, NY DE intrusion detection; battery; wireless security AB This paper proposes an innovative Battery-Sensing Intrusion Protection System (B-SIPS) for mobile computers, which alerts on power changes detected on small wireless devices. These hosts are employed as sensors in a wireless network and form the basis of the "Canary-Net" intrusion detection system (IDS). This detection capability is scalable and complementary with existing commercial and open system network IDSs. B-SIPS implementation correlates device power consumption with IEEE 802.11 and Bluetooth communication activity. Irregular and attack activity is detected and reported to the intrusion detection engine for correlation with existing signatures in a database and for forensic investigation by a security manager. C1 [Buennemeyer, Timothy K.; Chiang, Wayne G.; Tront, Joseph G.] Virginia Polytech Inst & State Univ, Dept Elect & Comp Engn, Blacksburg, VA 22061 USA. [Jacoby, Grant A.] US Mil Acad, West Point, NY 10996 USA. [Marchany, Randolph C.] Virginia Polytech Inst & State Univ, Informat Technol & Secur Lab, Blacksburg, VA 22061 USA. RP Buennemeyer, TK (reprint author), Virginia Polytech Inst & State Univ, Dept Elect & Comp Engn, Blacksburg, VA 22061 USA. EM timb@vt.edu; grantjacob@usma.edu; wehiang@vt.edu; marchany@vt.edu; jgtront@vt.edu NR 23 TC 1 Z9 1 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0129-1 PY 2006 BP 176 EP + DI 10.1109/IAW.2006.1652093 PG 2 WC Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BFR98 UT WOS:000244121300025 ER PT S AU Salem, TE Ibitayo, D Geil, BR AF Salem, Thomas E. Ibitayo, Dimeji Geil, Bruce R. GP IEEE TI A technique for die surface temperature measurement of high-voltage power electronic components using coated thermocouple probes SO 2006 IEEE INSTRUMENTATION AND MEASUREMENT TECHNOLOGY CONFERENCE PROCEEDINGS, VOLS 1-5 SE IEEE Instrumentation and Measurement Technology Conference LA English DT Proceedings Paper CT 23rd IEEE Instrumentation and Measurement Technology Conference CY APR 24-27, 2006 CL Sorrento, ITALY SP IEEE Instrumentat & Measurement Soc DE thermocouple probe; temperature measurement; high-voltage AB The performance capabilities of high-voltage high-power systems is significantly impacted by the thermal limitations of power electronic components. To address this issue, numerous current research efforts have been conducted to examine advanced pachaging materials and structures as well as novel cooling techniques. Critical to the success of this work is the accurate measurement and characterization of the thermal characteristics of the power electronic components. This paper presents a methodology and assessment of using coated thermocouple probes for measuring the die surface temperature of active high-voltage power electronic components. C1 [Salem, Thomas E.] USN Acad, Dept Elect Engn, 105 Maryland Ave, Annapolis, MD 21402 USA. [Ibitayo, Dimeji; Geil, Bruce R.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Salem, TE (reprint author), USN Acad, Dept Elect Engn, 105 Maryland Ave, Annapolis, MD 21402 USA. NR 5 TC 0 Z9 0 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1091-5281 BN 978-0-7803-9359-2 J9 IEEE IMTC P PY 2006 BP 651 EP + DI 10.1109/IMTC.2006.328661 PG 2 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BFS10 UT WOS:000244176701036 ER PT B AU Bertozzi, M Broggi, A Felisa, M Vezzoni, G Rose, M AF Bertozzi, M. Broggi, A. Felisa, M. Vezzoni, G. Del Rose, M. GP IEEE TI Low-level pedestrian detection by means of visible and far infra-red tetra-vision SO 2006 IEEE INTELLIGENT VEHICLES SYMPOSIUM LA English DT Proceedings Paper CT IEEE Intelligent Vehicles Symposium CY JUN 13-15, 2006 CL Meguroku, JAPAN SP IEEE AB This article presents a tetra-vision (4 cameras) system for the detection of pedestrians by the means of the simultaneous use of one far infra-red and one visible cameras stereo pairs. The main idea is to exploit both the advantages of far infra-red and visible cameras trying at the same time to benefit from the use of each system. Initially, the two stereo flows are independently processed, then the results are fused together. The final result of this low-level processing is a list of obstacles that have a shape and a size compatible with the presence of a potential pedestrian. In addition, the system is able to remove the background from the detected obstacles to simplify a possible further high level processing. C1 [Bertozzi, M.; Broggi, A.; Felisa, M.; Vezzoni, G.] Univ Parma, Dipartimento Ingn Informazione, I-43100 Parma, Italy. [Del Rose, M.] US Army TARDEC, Vet Res Ctr, Warren, MI USA. RP Bertozzi, M (reprint author), Univ Parma, Dipartimento Ingn Informazione, I-43100 Parma, Italy. EM bertozzi@ce.unipr.it; broggi@ce.unipr.it; felisa@ce.unipr.it; vezzoni@ce.unipr.it; DelRoseM@tacom.army.mil OI Bertozzi, Massimo/0000-0003-1463-5384; Broggi, Alberto/0000-0002-0893-1331 FU European Research Office of the U. S. Army [N62558-05-P-0380] FX This work has been supported by the European Research Office of the U. S. Army under contract number N62558-05-P-0380. NR 26 TC 9 Z9 9 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 4-9011-2286-X PY 2006 BP 231 EP + DI 10.1109/IVS.2006.1689633 PG 2 WC Computer Science, Artificial Intelligence; Robotics; Transportation Science & Technology SC Computer Science; Robotics; Transportation GA BFI75 UT WOS:000242043800073 ER PT S AU Ghogho, M Swami, A AF Ghogho, Mounir Swami, Ananthram GP IEEE TI Training design for channel and CFO estimation in MIMO systems SO 2006 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, VOL IV, PROCESSING: SIGNAL PROCESSING FOR COMMUNICATION, SENSOR ARRAY AND MULTICHANNEL SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 31st IEEE International Conference on Acoustics, Speech and Signal Processing CY MAY 14-19, 2006 CL Toulouse, FRANCE SP IEEE Signal Proc Soc ID FREQUENCY OFFSET AB For MIMO systems operating over frequency-selective channels, we establish the Cramer-Rao Bound (CRB) for the CFO and channel parameters. We derive training sequences so that the resulting CRB on the CFO is independent of the channel. We show that these designs lead to simple implementation of the maximum likelihood estimators of the CFO and channel parameters, Simulation results illustrate the performance of the proposed designs. C1 [Ghogho, Mounir] Univ Leeds, Sch EEE, Leeds LS2 9JT, W Yorkshire, England. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Ghogho, M (reprint author), Univ Leeds, Sch EEE, Leeds LS2 9JT, W Yorkshire, England. EM m.ghogho@ieee.org; a.swami@ieee.org NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 J9 INT CONF ACOUST SPEE PY 2006 BP 81 EP + PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFW22 UT WOS:000245062900021 ER PT S AU Yang, LQ Swami, A AF Yang, Liuqing Swami, Ananthram GP IEEE TI Noncoherent demodulator for PPM-UWB radios SO 2006 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, VOL IV, PROCESSING: SIGNAL PROCESSING FOR COMMUNICATION, SENSOR ARRAY AND MULTICHANNEL SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 31st IEEE International Conference on Acoustics, Speech and Signal Processing CY MAY 14-19, 2006 CL Toulouse, FRANCE SP IEEE Signal Proc Soc DE signal processing for communication; ultra wideband communication ID WIDE-BAND COMMUNICATIONS; MULTIPATH CHANNELS; PERFORMANCE; MODULATION AB Low-duty-cycle Ultra-wideband (UWB) radios have the potential to provide low-probability of detection (LPD) communications with low-power and low-complexity implementation. Pulse position modulation (PPM) is a prevalent scheme for UWB radios since it can further lower the transmitter complexity by avoiding pulse negation. However, the position shifts of impulse-like UWB waveforms, together with the severe frequency-selectivity of the propagation channels, aggravate the difficulty and complexity of timing synchronization and channel estimation. To circumvent both of these challenging tasks, we develop a differential encoder and its corresponding non-coherent demodulator for PPM-UWB signals. Relying on integrate-and-dump operations of "dirty" templates, our designs are operational when the timing offset and channel information both remain unknown. C1 [Yang, Liuqing] Univ Florida, Dept ECE, POB 116130, Gainesville, FL 32611 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Yang, LQ (reprint author), Univ Florida, Dept ECE, POB 116130, Gainesville, FL 32611 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 J9 INT CONF ACOUST SPEE PY 2006 BP 501 EP + PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFW22 UT WOS:000245062900126 ER PT S AU Haynes, K Liu, X Mio, W AF Haynes, Keith Liu, Xiuwen Mio, Washington GP IEEE TI Recognition using rapid classification tree SO 2006 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, ICIP 2006, PROCEEDINGS SE IEEE International Conference on Image Processing ICIP LA English DT Proceedings Paper CT IEEE International Conference on Image Processing (ICIP 2006) CY OCT 08-11, 2006 CL Atlanta, GA SP IEEE DE object recognition; object classification; feature extraction; image analysis; face recognition AB This paper proposes a method to achieve object classification with high throughput and accuracy using a rapid classifcation tree. To achieve this, we decouple the training and test stages. During the training stage, we learn optimal discriminatory features from the training set and then train a classifier with high accuracy. Then we create a classifcation tree, where each node uses a lookup table to store the solutions, resulting high throughput at the test stage. To make the lookup tables feasible for applications, we learn a projection matrix through stochastic optimization. We illustrate the effectiveness of the proposed method using several datasets; our results show the proposed method achieves often several orders of magnitudes of improvement in throughput while maintaining a similar accuracy. C1 [Haynes, Keith] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Liu, Xiuwen] Florida State Univ, Dept Comp Sci, Tallahassee, FL 32306 USA. [Mio, Washington] Florida State Univ, Dept Mech, Tallahassee, FL 32306 USA. RP Haynes, K (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-4880 BN 978-1-4244-0481-0 J9 IEEE IMAGE PROC PY 2006 BP 2753 EP + DI 10.1109/ICIP.2006.313117 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Software Engineering; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA BGA25 UT WOS:000245768501307 ER PT S AU Page, DL Koschan, AF Abidi, MA Overholt, JL AF Page, D. L. Koschan, A. F. Abidi, M. A. Overholt, J. L. GP IEEE TI Ridge-valley path planning for 3D terrains SO 2006 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA), VOLS 1-10 SE IEEE International Conference on Robotics and Automation ICRA LA English DT Proceedings Paper CT IEEE International Conference on Robotics and Automation (ICRA) CY MAY 15-19, 2006 CL Orlando, FL SP IEEE ID LINES AB This paper presents a tactical path planning algorithm for following ridges or valleys across a 3D terrain. The intent is to generate a path that enables an unmanned vehicle to surveil with maximum observability by traversing the ridges of a terrain or to operate with maximum covertness by navigating the valleys. The input to the algorithm is a 3D triangle mesh model for the terrain of interest. This mesh may be non-uniform and non-regular. Thus, the algorithm leverages research from computer graphics and computer vision to identify ridge-valley features on the terrain. These features serve as "obstacles" for an artificial potential field algorithm. The valleys are obstacles for a surveillance path, or the ridges are obstacles for a covert path. We incorporate geodesic-rather than Euclidean-distances into the potential field formulation to extend path planning to 3D surfaces. We present the theory of our proposed algorithm and provide experimental results. C1 [Page, D. L.; Koschan, A. F.; Abidi, M. A.] Univ Tennessee, Ferris Hall 336, Knoxville, TN 37996 USA. [Overholt, J. L.] US Army TARDEC, Robot Mobil Lab, Warren, MI 48397 USA. RP Page, DL (reprint author), Univ Tennessee, Ferris Hall 336, Knoxville, TN 37996 USA. EM dpage@utk.edu; akoschan@utk.edu; abidi@utk.edu; jim.overholt@us.army.mil OI Page, David/0000-0003-3353-4300 FU University Research Program in Robotics [DOE-DE-FG52-2004NA25589]; DOD/RDECOM/NAC/ARC Program [W56HZV-04-2-0001] FX This work is supported by the University Research Program in Robotics under grant DOE-DE-FG52-2004NA25589 and by the DOD/RDECOM/NAC/ARC Program under grant W56HZV-04-2-0001. NR 21 TC 5 Z9 5 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1050-4729 BN 0-7803-9505-0 J9 IEEE INT CONF ROBOT PY 2006 BP 119 EP + DI 10.1109/ROBOT.2006.1641171 PG 2 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Engineering, Mechanical; Robotics SC Automation & Control Systems; Computer Science; Engineering; Robotics GA BFB71 UT WOS:000240886900020 ER PT S AU Lever, JH Streeter, A Ray, LR AF Lever, J. H. Streeter, A. Ray, L. R. GP IEEE TI Performance of a solar-powered robot for polar instrument networks SO 2006 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA), VOLS 1-10 SE IEEE International Conference on Robotics and Automation ICRA LA English DT Proceedings Paper CT IEEE International Conference on Robotics and Automation (ICRA) CY MAY 15-19, 2006 CL Orlando, FL SP IEEE DE mobile robot design; power system control AB The Cool Robot is a four-wheel-drive, solar-powered autonomous vehicle designed to support summertime science campaigns in Antarctica and Greenland. We deployed the robot at Summit Camp, Greenland, during 2005 to validate its power budget and to assess its unique control system that matches solar power input with power demand as the robot drives over rough terrain. The 61-kg robot drove continuously at 0.78 m/s on soft snow, its 160-W average power demand met by solar power alone under clear skies when sun elevation exceeded 16. The power-control system reliably matched input with demand as insolation changed during the tests. A simple GPS waypoint-following algorithm provided reliable autonomous navigation over periods of 5 - 8 hours. The data validate our design models and indicate that the Cool Robot will exceed its design goal of carrying a 15-kg payload 500 km in two weeks on, the Antarctic plateau. C1 [Lever, J. H.] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Streeter, A.; Ray, L. R.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Lever, JH (reprint author), US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.h.lever@erdc.usace.army.mil; Laura.E.Ray@Dartmouth.EDU FU NSF [OPP-0343328]; NIST [60NANB4D1144]; Army AT42 work unit Mobility of Lightweight Robotic Vehicles; Institute for Security Technology Studies by the Bureau of Justice Assistance [2005- DD-BX-1091] FX This work is supported by NSF grant OPP-0343328, NIST grant 60NANB4D1144, Army AT42 work unit Mobility of Lightweight Robotic Vehicles, and grant 2005- DD-BX-1091 awarded to the Institute for Security Technology Studies by the Bureau of Justice Assistance NR 10 TC 11 Z9 11 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1050-4729 BN 0-7803-9505-0 J9 IEEE INT CONF ROBOT PY 2006 BP 4252 EP + DI 10.1109/ROBOT.2006.1642356 PG 2 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Engineering, Mechanical; Robotics SC Automation & Control Systems; Computer Science; Engineering; Robotics GA BFB71 UT WOS:000240886909029 ER PT S AU Jones, AS Rapp, D Combs, CL Longmore, S Vukicevic, T Haar, THV Mc Williams, G Munguiole, M Mason, G Chauhan, NS AF Jones, Andrew S. Rapp, Dustin Combs, Cynthia L. Longmore, Scott Vukicevic, Tomislava Haar, Thomas H. Vonder Mc Williams, Gary Munguiole, Michael Mason, George Chauhan, Narinder S. GP IEEE TI NPOESS Soil Moisture Satellite Data Assimilation and RFI Mitigation: Use of WindSat Data and a Discrete Backus-Gilbert Technique SO 2006 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM, VOLS 1-8 SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 31-AUG 04, 2006 CL Denver, CO SP IEEE, IEEE Geosci & Remote Sensing Soc, Canadian Remote Sensing Soc, NASA, NOAA, Off Naval Res, Natl Polar Orbiting Operat Environm Satellite Syst, Japan Aerosp Explorat Agcy, Ball Aerosp & Technologies Corp, Cooperat Inst Res Atmosphere, Colorado State Univ, Univ Colorado, Int Union Radio Sci DE soil moisture; data assimilation; passive microwave ID VARIATIONAL DATA ASSIMILATION AB This work develops (1) a four-dimensional data assimilation methodology to retrieve deep soil moisture profiles using the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and other associated data, (2) a methodology for better spatial mapping of the masking effects caused by surface features (i.e., vegetative cover and surface roughness), and (3) a discrete Backus-Gilbert (DBG)-based methodology for reducing the radio frequency interference impacts at 6.7 and 10 GHz. C1 [Jones, Andrew S.; Rapp, Dustin; Combs, Cynthia L.; Longmore, Scott; Vukicevic, Tomislava; Haar, Thomas H. Vonder] CIRA CSU, Ctr Geosci Atmospher Res, Ft Collins, CO USA. [Mc Williams, Gary; Munguiole, Michael] ARL, Adelphi, MD USA. [Mason, George] Army Corp Engn, ERDC, Vicksburg, MS USA. [Chauhan, Narinder S.] NPOESS IPO Aerosp, Silver Spring, MD USA. RP Jones, AS (reprint author), CIRA CSU, Ctr Geosci Atmospher Res, Ft Collins, CO USA. EM jones@cira.colostate.edu RI Jones, Andrew/D-3291-2012; vonderhaar, thomas/N-6724-2015 OI Jones, Andrew/0000-0002-0995-4957; vonderhaar, thomas/0000-0002-1962-7757 FU DoD Center for Geoscience/Atomospheric Research Colorado State University under the Cooperative Agreement [DAAD 19-02-2-005]; Army Research Laboratory; NPOESS Inter Governmental Studies Program(IGSP) FX This work was supported by the DoD Center for Geoscience/Atomospheric Research Colorado State University under the Cooperative Agreement DAAD 19-02-2-005 with the Army Research Laboratory and by the NPOESS Inter Governmental Studies Program(IGSP) NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-0-7803-9509-1 J9 INT GEOSCI REMOTE SE PY 2006 BP 2040 EP + DI 10.1109/IGARSS.2006.528 PG 2 WC Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Geology; Remote Sensing; Imaging Science & Photographic Technology GA BIN08 UT WOS:000260989401120 ER PT S AU Sun, XH Chen, W Fischer, RL Ruby, JG Eichholz, JC Baker, JJ Florence, DE AF Sun, Xiuhong Chen, William Fischer, Robert L. Ruby, Jeffrey G. Eichholz, James C. Baker, James J. Florence, Donald E. GP IEEE TI A Precision Geo-referenced Digital Airborne Camera System SO 2006 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM, VOLS 1-8 SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 31-AUG 04, 2006 CL Denver, CO SP IEEE, IEEE Geosci & Remote Sensing Soc, Canadian Remote Sensing Soc, NASA, NOAA, Off Naval Res, Natl Polar Orbiting Operat Environm Satellite Syst, Japan Aerosp Explorat Agcy, Ball Aerosp & Technologies Corp, Cooperat Inst Res Atmosphere, Colorado State Univ, Univ Colorado, Int Union Radio Sci DE Airborne Remote Sensing; Change Detection; High Resolution; Photogrammetry; Georeference; Orthomosaic; Digital Camera; GPS; IMU; System Integration; PC Instrumentation AB A Precision Geo-referenced Digital Airborne Camera System (PG-DACS) is fully integrated with the latest 16-bit 4x5cm format CCD camera, a precision GPS/IMU setup, a customized high performance industrial PC, and a dedicated PG-DACS operation autonomous software package. PG-DACS is a self-sustained portable airborne imaging system that can be quickly deployed aboard various fixed and rotary wing aerial vehicles. PG-DACS is developed for today's fast change detection needs with the leading performance in providing high spatial and temporal resolution, photogrammetric-grade aerial image products. Direct-georeference-capable, sub-inch resolution spotting airphotos, and two to six inch resolution continuous aerial stereo pairs for radiometrically corrected mapping-grade orthomosaics that cover long corridor and various sized cities and counties are parts of PG-DACS products. C1 [Sun, Xiuhong; Chen, William; Baker, James J.; Florence, Donald E.] Flight Landata Inc, Lawrence, MA 01843 USA. [Fischer, Robert L.] SAIC, Springfield, VA 22150 USA. [Ruby, Jeffrey G.; Eichholz, James C.] U S Army Topog Engn Ctr, ERDC, Alexandria, VA 22315 USA. RP Sun, XH (reprint author), Flight Landata Inc, Lawrence, MA 01843 USA. NR 6 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-0-7803-9509-1 J9 INT GEOSCI REMOTE SE PY 2006 BP 2048 EP + DI 10.1109/IGARSS.2006.530 PG 2 WC Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Geology; Remote Sensing; Imaging Science & Photographic Technology GA BIN08 UT WOS:000260989401122 ER PT S AU Gurfinkel, M Suehle, J Bernstein, JB Shapira, Y Lelis, AJ Habersat, D Goldsman, N AF Gurfinkel, M. Suehle, J. Bernstein, J. B. Shapira, Y. Lelis, A. J. Habersat, D. Goldsman, N. GP IEEE TI Ultra-fast measurements of V-TH instability in SiC MOSFETs due to positive and negative constant bias stress SO 2006 IEEE INTERNATIONAL INTEGRATED RELIABILITY WORKSHOP, FINAL REPORT SE IEEE International Integrated Reliability Workshop Final Report LA English DT Proceedings Paper CT IEEE International Integrated Reliability Workshop CY OCT 16-19, 2006 CL S Lake Tahoe, CA ID MOBILITY AB One of the most important issues that limits the performance and reliability of SiC power MOSFETs is the threshold voltage instability under normal operation conditions. This phenomenon has been recently studied using dc sweep measurements. In this work, we studied the threshold voltage instability using fast I-V measurements. The results show that under positive bias, V-TH shifts to more positive values, while it shifts to more negative values under negative bias. Fast I-V measurements reveal the full extent of the V-TH instability, underestimated by the dc measurements. Furthermore, fast measurements allow the separation of negative and positive bias stress effects. A physical model involving fast transient charge trapping and de-trapping at and near the SiC/SiO2 interface is proposed. C1 [Gurfinkel, M.; Bernstein, J. B.; Goldsman, N.] Univ Maryland, College Pk, MD 20742 USA. [Suehle, J.] NIST, Div Semicond Elect, Gaithersburg, MD 20899 USA. [Shapira, Y.; Lelis, A. J.; Habersat, D.] Tel Aviv Univ, Sch Elect Engn, IL-66978 Tel Aviv, Israel. U S Army Res Lab, Adelphi, MD 20783 USA. RP Gurfinkel, M (reprint author), Univ Maryland, College Pk, MD 20742 USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-8841 BN 978-1-4244-0296-0 J9 INT INTEG REL WRKSP PY 2006 BP 49 EP + DI 10.1109/IRWS.2006.305209 PG 3 WC Engineering, Electrical & Electronic; Physics, Condensed Matter SC Engineering; Physics GA BFX08 UT WOS:000245236100011 ER PT S AU Lelis, AJ Potbhare, S Habersat, D Pennington, G Goldsman, N AF Lelis, A. J. Potbhare, S. Habersat, D. Pennington, G. Goldsman, N. GP IEEE TI Modeling and characterization of bias stress-induced instability of SiC MOSFETs SO 2006 IEEE INTERNATIONAL INTEGRATED RELIABILITY WORKSHOP, FINAL REPORT SE IEEE International Integrated Reliability Workshop Final Report LA English DT Proceedings Paper CT IEEE International Integrated Reliability Workshop CY OCT 16-19, 2006 CL S Lake Tahoe, CA AB Threshold voltage instability due to bias stressing has been observed in SiC MOSFETs. Stressing at high gate bias has caused shifts up to several hundred millivolts in the threshold voltage of SiC MOSFETs which can significantly affect circuit performance. We have tried to characterize this threshold voltage instability by experimental and numerical modeling analyses. We see appreciable instability for stress times as less as 10s and stress voltages as low as 4V. Comparison of experiment and simulation indicates that this threshold voltage instability is caused due to excess oxide trapped charge, and also that the instability is reversible. C1 [Lelis, A. J.; Habersat, D.] US Army, Res Lab, Adelphi, MD 20783 USA. [Potbhare, S.; Pennington, G.; Goldsman, N.] Univ Maryland, College Pk, MD 20742 USA. RP Lelis, AJ (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM alelis@arl.army.mil; potbhare@umd.edu NR 7 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-8841 BN 978-1-4244-0296-0 J9 INT INTEG REL WRKSP PY 2006 BP 160 EP + DI 10.1109/IRWS.2006.305235 PG 2 WC Engineering, Electrical & Electronic; Physics, Condensed Matter SC Engineering; Physics GA BFX08 UT WOS:000245236100037 ER PT S AU Brudnak, M AF Brudnak, Mark GP IEEE TI Vector-valued support vector regression SO 2006 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORK PROCEEDINGS, VOLS 1-10 SE IEEE International Joint Conference on Neural Networks (IJCNN) LA English DT Proceedings Paper CT IEEE International Joint Conference on Neural Network CY JUL 16-21, 2006 CL Vancouver, CANADA SP IEEE AB A vector-valued extension of the support vector regression problem is presented here. The vector-valued variant is developed by extending the notions of the estimator, loss function and regularization functional from the scalar-valued case. A particular emphasis is placed on the class of loss functions chosen which apply the E-insensitive loss function to the p-norm of the error. The primal and dual optimization problems are derived and the KKT conditions are developed. The general case for the p-norm is specialized for the 1-, 2-and infinity-norms. It is shown that the vector-valued variant is a true extension of the scalar-valued case. It is then shown that the vector-valued approach results in sparse representations in terms of support vectors as compared to aggregated scalar-valued learning. C1 USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Brudnak, M (reprint author), USA, RDECOM TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA. EM brudnakm@tacom.army.mil NR 13 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1098-7576 BN 978-0-7803-9490-2 J9 IEEE IJCNN PY 2006 BP 1562 EP 1569 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BFW67 UT WOS:000245125902074 ER PT S AU Evangelista, PF Embrechts, MJ Szymanski, BK AF Evangelista, Paul F. Embrechts, Mark J. Szymanski, Boleslaw K. GP IEEE TI Data fusion for outlier detection through pseudo-ROC curves and rank distributions SO 2006 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORK PROCEEDINGS, VOLS 1-10 SE IEEE International Joint Conference on Neural Networks (IJCNN) LA English DT Proceedings Paper CT IEEE International Joint Conference on Neural Network CY JUL 16-21, 2006 CL Vancouver, CANADA SP IEEE ID SUPPORT; AREA AB This paper proposes a novel method of fusing models for classification of unbalanced data. The unbalanced data contains a majority of healthy (negative) instances, and a minority of unhealthy (positive) instances. The applicability of this type of classification problem with security applications inspired the naming of such problems as security classification problems (SCP). The area under the ROC curve (AUC) is the metric utilized to measure classifier performance, and in order to better understand AUC and ROC behavior, pseudo-ROC curves created from simulated data are introduced. ROC curves depend entirely upon the rankings created by classifiers. The rank distributions discussed in this paper display classifier performance in a novel form, and the behavior of these rank distributions provides insight into classifier fusion for the SCP. Rank distributions, which illustrate the probability of a particular rank containing a positive or negative instance, will be introduced and used to explain why synergistic classifier fusion occurs. C1 [Evangelista, Paul F.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Embrechts, Mark J.] Rensselaer Polytech Inst, Dept Decis Sci & Engn syst, Troy, NY 12180 USA. [Szymanski, Boleslaw K.] Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY 12180 USA. RP Evangelista, PF (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM paul.evangelista@usma.edu; embrem@rpi.edu; szymansk@rpi.edu RI Szymanski, Boleslaw/A-9121-2009 OI Szymanski, Boleslaw/0000-0002-0307-6743 NR 25 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2161-4393 BN 978-0-7803-9490-2 J9 IEEE IJCNN PY 2006 BP 2166 EP + PG 2 WC Computer Science, Artificial Intelligence SC Computer Science GA BFW67 UT WOS:000245125904003 ER PT S AU Wichern, G Azimi-Sadjadi, MR Mungiole, M AF Wichern, Gordon Azimi-Sadjadi, Mahmood R. Mungiole, Michael GP IEEE TI An environmentally adaptive system for rapid acoustic mransmission loss prediction SO 2006 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORK PROCEEDINGS, VOLS 1-10 SE IEEE International Joint Conference on Neural Networks (IJCNN) LA English DT Proceedings Paper CT IEEE International Joint Conference on Neural Network CY JUL 16-21, 2006 CL Vancouver, CANADA SP IEEE ID NEURAL-NETWORK; ATMOSPHERE; MODELS AB An environmentally adaptive system for prediction of acoustic transmission loss (TL) in the atmosphere is developed in this paper. This system uses expert neural network predictors, each corresponding to a specific environmental condition. The outputs of the expert predictors are combined using a fuzzy confidence measure and a non-linear fusion system. Using this prediction methodology the computational intractability of traditional acoustic models is eliminated. The proposed system is tested on a synthetic acoustic data set for a wide range of geometric, source, and environmental conditions. C1 [Wichern, Gordon; Azimi-Sadjadi, Mahmood R.] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. [Mungiole, Michael] Army Res Lab, Adelphi, MD 20783 USA. RP Wichern, G (reprint author), Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. EM azimi@engr.colostate.edu; mmungiole@arl.army.mil FU DoD Center for Geo sciences/Atmospheric Research at Colorado State University via Cooperative Agreement [DAAD19-02-2-0005]; Army Research Laboratory. FX This research is supported by the DoD Center for Geo sciences/Atmospheric Research at Colorado State University via Cooperative Agreement DAAD19-02-2-0005 with the Army Research Laboratory. NR 16 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2161-4393 BN 978-0-7803-9490-2 J9 IEEE IJCNN PY 2006 BP 5118 EP 5125 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BFW67 UT WOS:000245125909041 ER PT B AU Lee, YM Anthony, TK AF Lee, Youn M. Anthony, Theodore K. GP IEEE TI A new technique to improve gasket performance that uses elastomer or rubber material SO 2006 IEEE INTERNATIONAL SYMPOSIUM ON ELECTROMAGNETIC COMPATIBILITY, VOLS 1-3, PROCEEDINGS LA English DT Proceedings Paper CT IEEE Symposium on Electromagnetic Compatibility CY AUG 01, 2006 CL Portland, OR SP IEEE AB Elastomer material loaded with conductive metal :powder is frequently used as EMI (electromagnetic interference) gaskets, and open or closed cell polymer or rubber is used as the core material of wire-mesh gasket or conductive fabric: Reported and well documented, and many shielding effectiveness test personnel know hat, especially on some applications requiring very high level of shielding, these gaskets frequently fail to meet performance requirements because of compression set 11. New test results reveal ways to circumvent this kind,of failure, and we suggest a new test procedure in :choosing the polymer material to address the existing problem. C1 [Lee, Youn M.; Anthony, Theodore K.] USA, Res Lab, Adelphi, MD 20783 USA. RP Lee, YM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0293-9 PY 2006 BP 139 EP 144 DI 10.1109/ISEMC.2006.1706280 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BII44 UT WOS:000259733100030 ER PT S AU Hudson, T Holt, S Ruffin, P McKee, J Whitley, M Kranz, M Tuck, E AF Hudson, Tracy Holt, Sherrie Ruffin, Paul McKee, Jim Whitley, Michael Kranz, Michael Tuck, Eric GP IEEE TI Multi-sensor inertial array technologies for advanced microsystems SO 2006 IEEE/ION POSITION, LOCATION AND NAVIGATION SYMPOSIUM, VOLS 1-3 SE IEEE-ION Position Location and Navigation Symposium LA English DT Proceedings Paper CT IEEE/ION Position, Location, and Navigation Symposium CY APR 24-27, 2006 CL Coronado, CA SP IEEE, ION ID MEMS GYROSCOPE AB This paper details the results of a three-year Army component technology development program, originating in 2003, to investigate the use of controlled arrays of MEMS sensors to provide full dynamic performance ranges, improved harsh environment tolerances, and improved reliability for miniature sensing systems, focusing on inertial applications. The prototyped devices focused on two technical challenges: 1) extending the performance range through the use of multiplexed sensor arrays, and 2) tightly-coupled sensors integration and feedback for control. Representative results are presented for two unique multiplexed accelerometer sensor arrays: one based on commercial-off-the-shelf (COTS) accelerometers and the other based on custom co-fabricated SOI MEMS accelerometers. Associated prototype electronics and data-merging algorithms, to demonstrate dynamic range expansion from 10 boolean AND 14 to 10 boolean AND 6, are also presented. Additionally, representative data in the investigation of tightly-coupled sensors integration will spotlight development of co-fabricated sensors for inertial applications that include an angular rate sensor, accelerometer array, and temperature sensors co-located on an individual SOI die. C1 [Hudson, Tracy; Holt, Sherrie; Ruffin, Paul] USA, AMRDEC, Redstone Arsenal, AL 35898 USA. [McKee, Jim; Whitley, Michael; Kranz, Michael] Morgan Res Corp, Huntsville, AL USA. [Tuck, Eric] Aegis Technol Grp, Huntsville, AL USA. RP Hudson, T (reprint author), USA, AMRDEC, Redstone Arsenal, AL 35898 USA. NR 18 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-358X BN 0-7803-9453-4 J9 IEEE POSITION LOCAT PY 2006 BP 574 EP + DI 10.1109/PLANS.2006.1650647 PG 2 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFG11 UT WOS:000241665600068 ER PT S AU Granthan, BE Bailey, MA AF Granthan, Brian E. Bailey, Mark A. GP IEEE TI A least-squares normalized error regression algorithm with application to the Allan variance noise analysis method SO 2006 IEEE/ION POSITION, LOCATION AND NAVIGATION SYMPOSIUM, VOLS 1-3 SE IEEE-ION Position Location and Navigation Symposium LA English DT Proceedings Paper CT IEEE/ION Position, Location, and Navigation Symposium CY APR 24-27, 2006 CL Coronado, CA SP IEEE, ION AB Over the last decade, extensive advances in digital computing have enabled the integration of navigation aids into tightly coupled navigation systems. These systems often include an error model of the inertial system that is continuously updating and compensating for inertial system error parameters. In these systems, inertial sensor random noise often becomes the limiting factor in performance. Therefore, it is more critical than ever to have accurate characterization of sensor random noise. This paper documents a specialized form of the weighted least-squares error regression algorithm that results in a least-squares normalized-error (LSNE) regression. This algorithm weights the error from the curve fit by the reciprocal of the value of the curve fit. This fitting method is applied to the Allan variance method of noise analysis to arrive at five typical noise coefficients including random walk and bias instability. The fit technique presented is less complex, requires less computation time, and does not have convergence issues compared to iterative logarithmic methods that are typically used for fitting Allan variance data. Random noise coefficients estimated using this method are compared against other regression methods with good agreement. The authors' form of implementation is presented. An easy-m to-use graphical user interface (GM application was developed to generate the Allan variance cluster data and calculate the curve fit from time domain data, while providing a visual presentation of the data and a simple means of fit parameter adjustment. C1 [Granthan, Brian E.] USA, Navigat & Control Technol Div, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL USA. [Bailey, Mark A.] Navigat Technol Associates Inc, Huntsville, AL USA. RP Granthan, BE (reprint author), USA, Navigat & Control Technol Div, Aviat & Missile RDEC, RDECOM, Redstone Arsenal, AL USA. NR 5 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-358X BN 0-7803-9453-4 J9 IEEE POSITION LOCAT PY 2006 BP 750 EP + DI 10.1109/PLANS.2006.1650671 PG 2 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFG11 UT WOS:000241665600090 ER PT S AU Graham, GS Couch, PK Peake, KR AF Graham, G. S. Couch, P. K. Peake, K. R. GP IEEE TI Simplified survey system user trial SO 2006 IEEE/ION POSITION, LOCATION AND NAVIGATION SYMPOSIUM, VOLS 1-3 SE IEEE-ION Position Location and Navigation Symposium LA English DT Proceedings Paper CT IEEE/ION Position, Location, and Navigation Symposium CY APR 24-27, 2006 CL Coronado, CA SP IEEE, ION C1 [Graham, G. S.; Couch, P. K.] USA, RDECOM, AMSRD AMR SG NC, Redstone Arsenal, AL 35898 USA. [Peake, K. R.] Navigat Technol Associates Inc, Huntsville, AL 35802 USA. RP Graham, GS (reprint author), USA, RDECOM, AMSRD AMR SG NC, Redstone Arsenal, AL 35898 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-358X BN 0-7803-9453-4 J9 IEEE POSITION LOCAT PY 2006 BP 814 EP + DI 10.1109/PLANS.2006.1650678 PG 2 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFG11 UT WOS:000241665600097 ER PT B AU Su, W Kosinski, JA Yu, M AF Su, Wei Kosinski, John A. Yu, Ming GP IEEE TI Dual-use of modulation recognition techniques for digital communication signals SO 2006 IEEE LONG ISLAND SYSTEMS, APPLICATIONS AND TECHNOLOGY CONFERENCE LA English DT Proceedings Paper CT 2nd Annual IEEE Long Island Systems, Applications and Technology Conference CY MAY 05, 2006 CL Farmingdale, NY SP IEEE ID CLASSIFICATION AB Automatic modulation recognition is not only an important military subject but also an emerging topic for next generation software-defined radios. This paper reviews the concept of blind modulation classification algorithms, discusses the similarity and diversity of various approaches, indicates difference for military and commercial applications, and analyzes the automatic modulation recognition methods based on software-defined radios. C1 [Su, Wei; Kosinski, John A.] US Army, CERDEC, Ft Monmouth, NJ 07703 USA. [Yu, Ming] SUNY Binghamton, Binghamton, NY 13902 USA. RP Su, W (reprint author), US Army, CERDEC, Ft Monmouth, NJ 07703 USA. NR 44 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0299-1 PY 2006 BP 5 EP + PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BHB97 UT WOS:000252137500002 ER PT S AU Darwish, AM Boutros, K Luo, B Huebschman, B Viveiros, E Hung, HA AF Darwish, A. M. Boutros, K. Luo, B. Huebschman, B. Viveiros, E. Hung, H. A. GP IEEE TI 4-Watt Ka-band AlGaN/GaN power amplifier MMIC SO 2006 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-5 SE IEEE MTT-S International Microwave Symposium LA English DT Proceedings Paper CT IEEE MTT-S International Microwave Symposium CY JUN 11-16, 2006 CL San Francisco, CA SP IEEE MTTS AB A broadband Ka-band AlGaN/GaN on SiC HEMT power amplifier MAC was developed for millimeter-wave antenna applications. The output stage is composed of a 1.2-mm-wide device with 0.18 mu m gate length. The two-stage 50-ohm matched MMIC produces 13 +/- 1 dB of gain from 26 GHz to 36 GHz. At 35 GHz, the measured CW saturated output power was 4 W, indicating a power density of 3.3 W/mm. The power added efficiency was 23%. Across the band, the measured CW output power was > 2 W. While individual (or partially matched single stage) devices have been demonstrated with good output power, to the best of our knowledge, this is the first report of a 10GHz-bandwidth Ka-band GaN MMIC with high output power, gain, and return loss. C1 [Darwish, A. M.; Huebschman, B.; Viveiros, E.; Hung, H. A.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Boutros, K.; Luo, B.] Rockwell Sci Co LLC, Thousand Oaks, CA 91360 USA. RP Darwish, AM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU Army CTA program [DAAD19-01-2-0008] FX Work performed at Rockwell Scientific was partially funded by Army CTA program,Contract #DAAD19-01-2-0008 NR 9 TC 7 Z9 8 U1 1 U2 7 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-645X BN 978-0-7803-9541-1 J9 IEEE MTT S INT MICR PY 2006 BP 730 EP 733 DI 10.1109/MWSYM.2006.249737 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BFS69 UT WOS:000244379001076 ER PT S AU Clajus, M Cajipe, VB Hayakawa, S Tumer, TO Willson, PD AF Clajus, Martin Cajipe, Victoria B. Hayakawa, Satoshi Tuemer, Tuemay O. Willson, Paul D. GP IEEE TI Multi-Energy, Fast Counting Hybrid CZT Pixel Detector with Dedicated Readout Integrated Circuit SO 2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6 SE IEEE Nuclear Science Symposium Conference Record LA English DT Proceedings Paper CT 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors/ 2006 IEEE Nuclear Science Symposium CY OCT 29-NOV 04, 2006 CL San Diego, CA SP IEEE ID DENSITY; CT AB A new mixed signal front-end readout electronics integrated circuit (IC) called HILDA (Hyperspectral Imaging with Large Detector Arrays) has been developed for two-dimensional CdZnTe (CZT) pixel detector arrays. The CZT array is directly bonded on top of the IC. The CZT array and the HILDA-IC have matching geometric pixel/channel structure and dimensions, a 16 x 16 array of 0.5 mm x 0.5 mm pitch. They are mounted together using flip-chip bump bonding. The pixel detector and readout IC are designed for high-rate photon counting independently for each channel/pixel and multiple-energy binning up to eight energy bands. Therefore, eight images can be produced that represent identical slices in time and space but different energy bands. Several HILDA CZT pixel detector hybrids have been fabricated and tested. The CZT pixel detector, the readout IC and preliminary test results are presented in this paper. The main potential applications envisioned for this chip are industrial non-destructive inspection, security applications and CT scanners. C1 [Clajus, Martin; Cajipe, Victoria B.; Hayakawa, Satoshi; Tuemer, Tuemay O.] NOVA R&D Inc, Riverside, CA 92507 USA. [Willson, Paul D.] US Army, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Clajus, M (reprint author), NOVA R&D Inc, Riverside, CA 92507 USA. EM martin.clajus@novarad.com NR 9 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1082-3654 BN 978-1-4244-0561-9 J9 IEEE NUCL SCI CONF R PY 2006 BP 3602 EP 3606 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BUC53 UT WOS:000288875603147 ER PT S AU Sadjadi, F Chun, CCS Sullivan, A Gaunaurd, GC AF Sadjadi, Firooz Chun, Cornell C. S. Sullivan, Anders Gaunaurd, Guillermo C. GP IEEE TI Classifying dielectric mine-like objects using the Huynen-Fork polarization parameters SO 2006 IEEE RADAR CONFERENCE, VOLS 1 AND 2 SE IEEE Radar Conference LA English DT Proceedings Paper CT 2006 IEEE Radar Conference CY APR 24-27, 2006 CL Verona, NY SP IEEE Aerosp & Elect Syst Soc, Radar Syst Panel AB We present a polarimetric approach that can be used to characterize subsurface targets by means of ground-penetrating radar. Several quantities related to the Huynen-Fork parameters are basic to the study. These quantities are an expressible in terms of the elements of Sinclair matrix S, which in turn, can be determined as functions of frequency by an application of the method-of-moment (MoM). The method is applied to a mine-like object buried at various depths in a soil of specified dielectric and moisture properties. The quantities in question are the Stokes parameters, the elevation, azimuth, and polarizability angles, as well as the polarization ratios and the scattering eigenvalues which optimize the backscattered power. Some of these quantities are studied here and displayed in various graphs. These frequency dependent graphs exhibit useful symmetry properties. The plots of the polarizability angle (beta) vs. frequency seem to remain invariant with target depth, and exhibit resonance features that are later shown to agree well with other standard methods to estimate resonances such as Prony method. A simple analysis of the early-time resonances thus estimated is used to obtain acceptable mine dimensions. The agreement found implies that polarimetric techniques, such as present one, can also be used in the arsenal of techniques yielding target-ID clues. C1 [Sadjadi, Firooz] Lockheed Martin Corp, Eagan, MN 55121 USA. [Chun, Cornell C. S.] Phys Innovat Inc, Inver Grove Heights, MN 55076 USA. [Sullivan, Anders; Gaunaurd, Guillermo C.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sadjadi, F (reprint author), Lockheed Martin Corp, Eagan, MN 55121 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5764 BN 978-0-7803-9496-4 J9 IEEE RAD CONF PY 2006 BP 186 EP + DI 10.1109/RADAR.2006.1631795 PG 2 WC Engineering, Electrical & Electronic; Remote Sensing; Telecommunications SC Engineering; Remote Sensing; Telecommunications GA BFS08 UT WOS:000244174500029 ER PT S AU Goldman, GH AF Goldman, Geoffrey H. GP IEEE TI Comparison of the direction of arrival estimator for a circular aperture with triangular and square configurations SO 2006 IEEE Radar Conference, Vols 1 and 2 SE Radar Conference LA English DT Proceedings Paper CT 2006 IEEE Radar Conference CY APR 24-27, 2006 CL Verona, NY SP IEEE Aerosp & Elect Syst Soc, Radar Syst Panel AB The trade-offs between using an antenna with a circular aperture with phase centers in an isosceles triangular configuration versus a square configuration are examined for a semi-active seeker application. Estimators for azimuth and elevation angles were derived using small angle approximations and by minimizing the squared error. The variance and unambiguous angle of the estimators are determined. The theoretical and simulated results indicate that the error in the angular estimates for the triangular configuration is slightly smaller than the square configuration. C1 USA, Res Lab, Adelphi, MD USA. RP Goldman, GH (reprint author), USA, Res Lab, Adelphi, MD USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5764 BN 978-0-7803-9496-4 J9 RADAR CONF PY 2006 BP 195 EP 199 DI 10.1109/RADAR.2006.1631797 PG 5 WC Engineering, Electrical & Electronic; Remote Sensing; Telecommunications SC Engineering; Remote Sensing; Telecommunications GA BFS08 UT WOS:000244174500031 ER PT S AU Ranney, K Stanton, B Nguyen, L Sullivan, A Smith, G Wong, D Ressler, M Tran, C Costanza, J Kirose, G Kappra, K Sichina, J AF Ranney, Kenneth Stanton, Brian Nguyen, Lam Sullivan, Anders Smith, Gregory Wong, David Ressler, Marc Tran, Chi Costanza, John Kirose, Getachew Kappra, Karl Sichina, Jeffrey GP IEEE TI Borehole radar performance characteristics and applications for underground change detection SO 2006 IEEE RADAR CONFERENCE, VOLS 1 AND 2 SE IEEE Radar Conference LA English DT Proceedings Paper CT 2006 IEEE Radar Conference CY APR 24-27, 2006 CL Verona, NY SP IEEE Aerosp & Elect Syst Soc, Radar Syst Panel AB Low-frequency borehole radars have proven useful in recent years as tools for locating underground features, such as rock fissures and voids. In fact, these radar systems are now commercially available at multiple operating frequencies. Most of the borehole radar applications to date have utilized the systems in a tomographic mode because of its capability to locate a target between two boreholes. In this paper, we focus on the use of a borehole radar system in a reflective mode because of its capability to detect a target anywhere in the vicinity of the radar. As expected, the detection range of the system is severely limited due to two-way attenuation through the earth. Nonetheless, we show that it is possible to form a roughly focused range-vs.-depth image of the region surrounding the borehole. More importantly, by developing and implementing some straightforward signal processing techniques, we are able to detect the introduction of a target into an adjacent borehole in both the focused and the unfocused imagery. C1 [Ranney, Kenneth; Stanton, Brian; Nguyen, Lam; Sullivan, Anders; Smith, Gregory; Wong, David; Ressler, Marc; Tran, Chi; Costanza, John; Kirose, Getachew; Kappra, Karl; Sichina, Jeffrey] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Ranney, K (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 7 TC 2 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5764 BN 978-0-7803-9496-4 J9 IEEE RAD CONF PY 2006 BP 643 EP + DI 10.1109/RADAR.2006.1631868 PG 3 WC Engineering, Electrical & Electronic; Remote Sensing; Telecommunications SC Engineering; Remote Sensing; Telecommunications GA BFS08 UT WOS:000244174500102 ER PT S AU Liu, P Xu, ZY Sadler, BM AF Liu, P Xu, ZY Sadler, BM BE Heiter, G TI Narrowband interference suppression of an MTR-UWB transceiver SO 2006 IEEE RADIO AND WIRELESS SYMPOSIUM, PROCEEDINGS SE IEEE Radio and Wireless Symposium LA English DT Proceedings Paper CT IEEE Radio and Wireless Symposium (RWS) CY JAN 17-19, 2006 CL San Diego, CA SP IEEE Microwave Theory & Techn Soc, IEEE Commun Soc AB A recently proposed multiuser transmitted reference ultra wideband (MTR-UWB) transceiver not only provides much higher data rates' than a conventional TR-UWB system, but also enables multiuser communication effectively. This paper further investigates its narrowband interference suppression capability. Effects of different jamming parameters such as the number of jamming tones, jamming power, and data rate ratio of narrowband to UWB signals, are studied. Some insights into trade-offs between suppression of narrowband interfering signals and detection performance are illustrated. C1 Arkansas Tech Univ, Dept Elect Engn, Russellville, AR 72801 USA. Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. Army Res Lab, AMSRD ARL CI CN, Adelphi, MD 20783 USA. RP Arkansas Tech Univ, Dept Elect Engn, Russellville, AR 72801 USA. EM ping.liu@atu.edu; dxu@ee.ucr.edu; bsadler@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-2958 BN 0-7803-9412-7 J9 IEEE RADIO WIRELESS PY 2006 BP 539 EP 542 DI 10.1109/RWS.2006.1615213 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BEE59 UT WOS:000236963500136 ER PT B AU Hu, YH Yun, M Tang, D Choi, HA AF Hu, Yen-Hung Yun, Mira Tang, Debra Choi, Hyeong-Ah GP IEEE TI A Study of Traffic Survivability Under Malicious Attacks SO 2006 IEEE SARNOFF SYMPOSIUM SE IEEE Sarnoff Symposium LA English DT Proceedings Paper CT IEEE Sarnoff Symposium CY MAR 27-28, 2006 CL Princeton, NJ SP IEEE AB As the Internet becomes more mature and a part of our daily life, the management of its resources to provide guaranteed services is crucial and beyond the capability of every individual network domain. How to maintain its continuous services in critical conditions is a challenge and would affect the design of next generation network infrastructure. In this paper, we study the survivability of normal traffics under the influences of flooding-based denial of service attacks and propose a potential framework which would reduce such influences. Our research increases the understanding of the behaviors of flooding-based DoS attacks and provides potential trends for developing better malicious attack mitigating solutions. By taking advantages of the survivability of specific flows, the potential mechanisms will not change or only slightly change current network infrastructure and be able to perform quality of service for several existing applications with no or little investment. C1 [Hu, Yen-Hung] Hampton Univ, Dept Comp Sci, Hampton, VA 23666 USA. [Yun, Mira; Choi, Hyeong-Ah] George Washington Univ, Washington, DC 20052 USA. [Tang, Debra] US Army, CECOM, Software Engn Ctr, Ft Belvoir, VA 22060 USA. RP Hu, YH (reprint author), Hampton Univ, Dept Comp Sci, Hampton, VA 23666 USA. EM yenhung.hu@hamptonu.edu; mirayun@gwu.edu; debra.tang@us.army.mil; hchoi@gwu.edu NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0002-7 J9 IEEE SARNOFF SYMPOS PY 2006 BP 172 EP + PG 2 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BHY06 UT WOS:000257373800045 ER PT B AU Morris, DS Kwon, OJ AF Morris, Derek S. Kwon, Oh-Ju GP IEEE TI Transporting JPEG images over MIMO links in ad-hoc networks: an investigation SO 2006 IEEE SARNOFF SYMPOSIUM SE IEEE Sarnoff Symposium LA English DT Proceedings Paper CT IEEE Sarnoff Symposium CY MAR 27-28, 2006 CL Princeton, NJ SP IEEE DE communications; ad-hoc networks; mimo; simulation AB This paper reports an investigation into the transport of sensor-generated still images over, ad-hoc, energy-limited networks. MIMO technology was considered as a means of increasing the data rate over network links and thereby the image throughput of the network as a whole. The combining effect of MIMO block size, packet size, and the JPEG compression technique on the distortion of the received images was of particular interest. In addition, we consider two forms of receiving mechanism: Maximum Likelihood (ML) and the less complex Zero-Forcing (ZF). We centered our investigation on simulating link behavior starting with a base of MIMO models written in LabView that were previously developed at the University of Texas. Additions and modifications made to this base, verifying calculations written in Matlab, and the utility of Labview and Matlab in the investigation are described. JPEG images were transported over the resulting Labview simulation through Rayleigh fading and AWGN over a range of signal-to-noise ratios, with SISO, 2x2 MIMO, QPSK modulation, ML, and ZF receivers. The resulting Bit error rate vs. SNR curves are presented and are in agreement with theory. In addition the resulting JPEG image distortion is described. C1 [Morris, Derek S.] USA, CERDEC, Ft Monmouth, NJ USA. [Kwon, Oh-Ju] Agcy Def Dev, Seoul, South Korea. RP Morris, DS (reprint author), USA, CERDEC, Ft Monmouth, NJ USA. EM derek.morris2@us.army.mil; koj@add.re.kr NR 7 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0002-7 J9 IEEE SARNOFF SYMPOS PY 2006 BP 319 EP + PG 2 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BHY06 UT WOS:000257373800082 ER PT S AU Zhang, W Ma, XL Swami, A AF Zhang, Wei Ma, Xiaoli Swami, Ananthram GP IEEE TI Maximum diversity of MIMO-OFDM schemes with linear equalizers SO 2006 IEEE SENSOR ARRAY AND MULTICHANNEL SIGNAL PROCESSING WORKSHOP PROCEEDINGS, VOLS 1 AND 2 SE Proceedings of the IEEE Sensor Array and Multichannel Signal Processing Workshop LA English DT Proceedings Paper CT 4th IEEE Sensor Array and Multichannel Signal Processing Workshop CY JUL 12-14, 2006 CL Waltham, MA SP IEEE Signal Proc Soc, IEEE Boston Sect, Air Force Res Lab, Def Adv Res Projects Agcy, Air Force Off Sci Res, Off Naval Res ID PERFORMANCE AB MIMO-OFDM has been widely adopted for next generation communications because of its capability to boost the transmission rate and performance. For MITMO-OFDM systems, many designs successfully exploit the space-multipath diversity when maximum likelihood (ML) or near-ML detector, with its concomitant high complexity, is adopted at the receiver. In this paper, we quantify the performance of conventional linear equalizers for MIMO-OFDM designs. We also propose lattice-reduction (LR) aided linear equalizers to boost the performance of linear equalizers, and show that LR-aided linear equalizers achieve the same diversity order as that collected by ML detector, but with much reduced complexity. Simulation results corroborate the theoretical findings. C1 [Zhang, Wei; Ma, Xiaoli] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Zhang, W (reprint author), Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. EM zhangw1@ece.gatech.edu; xiaoli@ece.gatech.edu; a.swami@ieee.org NR 12 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1551-2282 BN 1-4244-0308-1 J9 PR IEEE SEN ARRAY PY 2006 BP 229 EP + PG 2 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BFN69 UT WOS:000243341900049 ER PT S AU Sadler, BM Kozick, RJ AF Sadler, Brian M. Kozick, Richard J. GP IEEE TI A survey of time delay estimation performance bounds SO 2006 IEEE SENSOR ARRAY AND MULTICHANNEL SIGNAL PROCESSING WORKSHOP PROCEEDINGS, VOLS 1 AND 2 SE Proceedings of the IEEE Sensor Array and Multichannel Signal Processing Workshop LA English DT Proceedings Paper CT 4th IEEE Sensor Array and Multichannel Signal Processing Workshop CY JUL 12-14, 2006 CL Waltham, MA SP IEEE Signal Proc Soc, IEEE Boston Sect, Air Force Res Lab, Def Adv Res Projects Agcy, Air Force Off Sci Res, Off Naval Res ID SIGNAL PARAMETER ESTIMATION; REALIZABLE LOWER BOUNDS; MEAN-SQUARE ERROR; BEARING ESTIMATION; FUNDAMENTAL LIMITATIONS; SENSOR ARRAYS; WAVE-FORM; NOISE; LOCALIZATION; ALGORITHMS AB (1) In this paper we review performance bounds, as well as some current trends, in time delay estimation (TDE). Research over several decades reveals that a few key parameters determine TDE performance. The most basic are the signal-to-noise ratio (SNR), and the signal time-bandwidth (TB) product; larger values for each are desirable. The Cramer-Rao bound (CRB) reveals asymptotic maximum-likelihood estimation (MLE) behavior with respect to TB and SNR. At moderate to lower SNR, TDEs generally break down as ambiguities arise due to increased noise and the cross-correlation of the signal, causing the TDE to deviate (often quite sharply) away from the CRB. Because it is a local bound, the CRB does not indicate the threshold behavior, and Ziv-Zakai and other bounds have been developed to handle this. When TD is measured between multiple sensors, the coherence between them can fundamentally limit the result, an effect that occurs in acoustics due to the turbulent atmosphere. We discuss modifications to the classical bounds that accommodate the coherence loss, and reveal a threshold coherence phenomenon. When communications and other signals are utilized for TDE, they may have significant nuisance parameters, including carrier uncertainty, unknown symbols, as well as effects due to an unknown channel. Recent TDE performance limits reveal the effect of these parameters for various signal models, including the impact of diversity channels on TDE. C1 [Sadler, Brian M.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Kozick, Richard J.] Bucknell Univ, Dept Elect Engn, Lewisburg, PA 17837 USA. RP Sadler, BM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 54 TC 1 Z9 1 U1 0 U2 6 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1551-2282 BN 1-4244-0308-1 J9 PR IEEE SEN ARRAY PY 2006 BP 282 EP + PG 3 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BFN69 UT WOS:000243341900060 ER PT B AU Sullivan, SP Halstead, LTCJ AF Sullivan, Shane P. Halstead, L. T. C. John GP IEEE TI Improved ballistic test and evaluation methodology SO 2006 IEEE SYSTEMS AND INFORMATION ENGINEERING DESIGN SYMPOSIUM LA English DT Proceedings Paper CT IEEE Systems and Information Engineering Design Symposium CY APR 28, 2006 CL Charlottesville, VA SP IEEE AB Ballistic test and evaluation of body armor is of great priority for the US Army to meet current operational needs. The current experimental design process centers on standardized threat level classifications and a baseline ballistic limit velocity, V50; both measures originate from the National Institute of Justice circa 1979. The measures are complex, statistical in nature, and yield large quantities of data. A methodology incorporating response surface techniques improves ballistic test and evaluation from a pass fail analysis of data to iterative, directional experiments with design intelligence. Without this mathematical direction, it is extremely difficult to analyze the multitude of factors and their interaction effects in order to attain product improvement. We provide a ballistic experimental design example to demonstrate the usefulness of this methodology and identify the potential for its application in future armor developments. C1 [Sullivan, Shane P.; Halstead, L. T. C. John] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Sullivan, SP (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM shane.p.sullivan@us.army.mil; John.Halstead@us.army.mil FU U.S. Academy Department of Systems Engineering; US Army PEO Soldier FX Manuscript received April 14, 2006. This work was supported in part by the U.S. Academy Department of Systems Engineering and US Army PEO Soldier. NR 12 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0473-5 PY 2006 BP 1 EP + DI 10.1109/SIEDS.2006.278704 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Transportation Science & Technology SC Computer Science; Engineering; Transportation GA BFW73 UT WOS:000245140100001 ER PT B AU Karhoff, BC Limb, JI Oravsky, SW Shephard, AD AF Karhoff, Brian C. Limb, Jason I. Oravsky, Shane W. Shephard, Alfred D. GP IEEE TI Eyes in the domestic sky: An assessment of sense and avoid technology for the Army's "Warrior" Unmanned Aerial vehicle. SO 2006 IEEE SYSTEMS AND INFORMATION ENGINEERING DESIGN SYMPOSIUM LA English DT Proceedings Paper CT IEEE Systems and Information Engineering Design Symposium CY APR 28, 2006 CL Charlottesville, VA SP IEEE AB The Program Manager of the Army's Unmanned Aerial Systems (UAS) awarded a contract for the Extended Range Multipurpose (ERMP) Unmanned Aerial System (UAS) to General Atomics Aeronautical Systems Inc (GA-ASI), nicknamed the "Warrior." Given the size, performance, range and endurance of the system, the Warrior system can be reasonably expected to operate within and require access to the National Airspace (NAS) and/or unrestricted airspace of host nations. Therefore, it must have posses an equivalent level of safety to that of a manned aircraft. Our project involves identifying sense and avoid requirements necessary to avoid collisions and potential technologies necessary for the Warrior ERMP to obtain routine access to the NAS. We evaluate SAA requirements and define criteria specific to the Warrior consistent with FAA guidelines. We then show potential technologies to meet SAA requirements specific to the airframe. Finally, our research submits a recommendations for the Army in its pursuit of effective sense and avoid technology. We used standard systems engineering practices to complete this project for our client. C1 [Karhoff, Brian C.; Limb, Jason I.; Oravsky, Shane W.; Shephard, Alfred D.] US Mil Acad, West Point, NY 10997 USA. RP Karhoff, BC (reprint author), US Mil Acad, West Point, NY 10997 USA. EM brian.karhoff@usma.edu; jason.limb@usma.edu; shane.oravsky@usma.edu; aflred.shephard@usma.edu FU United States Military Academy; General Atomics, Aerodyne; United States Army FX Manuscript received April 14 2006. This work was supported in part by the United States Military Academy, General Atomics, Aerodyne, and the United States Army. NR 11 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0473-5 PY 2006 BP 36 EP + DI 10.1109/SIEDS.2006.278710 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Transportation Science & Technology SC Computer Science; Engineering; Transportation GA BFW73 UT WOS:000245140100007 ER PT B AU Domme, S Hwang, P Kim, P Wang, M Sperling, B AF Domme, Sarah Hwang, Peter Kim, Philip Wang, Matthew Sperling, Brian GP IEEE TI A value based approach to determining top hazards in army ground vehicle operations SO 2006 IEEE SYSTEMS AND INFORMATION ENGINEERING DESIGN SYMPOSIUM LA English DT Proceedings Paper CT IEEE Systems and Information Engineering Design Symposium CY APR 28, 2006 CL Charlottesville, VA SP IEEE AB Every nine hours a US Army Soldier dies. Each and every death affects the lives and vitality of this great country while reducing our combat power against the current and future enemy. The Army Combat Readiness Center (CRC) has transformed into a knowledge center for all losses and is looking to this research as a means of identifying the most severe hazards in Army ground vehicle operations. To address this issue this research incorporates the values of the Army and its current decision-makers into a systematic and logical decision structure that analyzes existing hazards while identifying the most serious driving mishaps. This paper discusses the data analysis of 11,012 driving mishaps and the methods used to accurately identify the leading hazards in ground vehicle operations. This research confirms that Class A accurately reflects the distribution of the entire population of Army Accidents (Class A-C). Ultimately, this research provides empirical evidence that Motivation is the leading cause in driving mishaps. The results of this research provide the groundwork for the selection of controls to minimize driving mishaps, and preserve one of our country's greatest assets the American Soldier. C1 [Domme, Sarah; Hwang, Peter; Kim, Philip; Wang, Matthew; Sperling, Brian] US Mil Acad, West Point, NY 10996 USA. RP Domme, S (reprint author), US Mil Acad, West Point, NY 10996 USA. EM sarah.domme@usma.edu; peter.hwang@usma.edu; philip.kim@usma.edu; matthew.wang@usma.edu FU Department of Systems Engineering at West Point FX The research team thanks Lieutenant Colonel Brian Sperling for his time, dedication, and unfailing assistance throughout the course of this research. Without his help, these findings would not have been possible. The team also thanks the Department of Systems Engineering at West Point, for its funding and continued belief in the abilities of cadets. NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0473-5 PY 2006 BP 124 EP + DI 10.1109/SIEDS.2006.278725 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Transportation Science & Technology SC Computer Science; Engineering; Transportation GA BFW73 UT WOS:000245140100022 ER PT B AU Gutierrez, TA Stramara, KP Tanner, CH Wells, CK Sperling, B AF Gutierrez, Thomas A. Stramara, Kevin P. Tanner, Christopher H. Wells, Caleb K. Sperling, Brian GP IEEE TI US Army Casualty Assistance System SO 2006 IEEE SYSTEMS AND INFORMATION ENGINEERING DESIGN SYMPOSIUM LA English DT Proceedings Paper CT IEEE Systems and Information Engineering Design Symposium CY APR 28, 2006 CL Charlottesville, VA SP IEEE AB This paper researches improvements in the current Casualty Assistance Office and how it conducts its business. The purpose of the Casualty Assistance Office is to support the Casualty Assistance System (CAS). This system's purpose is to help the families of the Army's casualties get through one of the toughest times in their lives. The Casualty Assistance Officer (CAO) is the person assigned to each casualty to assist the survivors get through this troubled time. Since the commencement of the Global War on Terrorism, there has been a dramatic increase in casualties and there are indications of failure within the system. This research analyzes the CAS to identify possible (high payoff) improvements to the system. C1 [Gutierrez, Thomas A.; Stramara, Kevin P.; Tanner, Christopher H.; Wells, Caleb K.; Sperling, Brian] US Mil Acad, West Point, NY 10996 USA. RP Gutierrez, TA (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Thomas.Gutierrez@usma.edu; Kevin.Stramara@usma.edu; Christopher.Tanner@usma.edu; Caleb.Wells@usma.edu FU US Army ACT II program [DAAB07-99-C-K501] FX This work was supported by US Army ACT II program under contract number DAAB07-99-C-K501. The authors greatly acknowledge the support of Chaplain (Major) Mike Charles from US Army Chaplain Center and School (USACHCS), Ft. Jackson, SC, Chaplain (LTC) James Boelens from US Army Material Command (HQ AMC), and Christopher Mathews from US Army CECOM, Ft. Jackson, NJ. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0473-5 PY 2006 BP 180 EP + DI 10.1109/SIEDS.2006.278672 PG 3 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Transportation Science & Technology SC Computer Science; Engineering; Transportation GA BFW73 UT WOS:000245140100032 ER PT B AU Lee, M Noblin, J Reynolds, B Roberts, B Trainor, T AF Lee, Matthew Noblin, Jack Reynolds, Brian Roberts, Brad Trainor, Timothy GP IEEE TI 2005 BRAC attribute analysis SO 2006 IEEE SYSTEMS AND INFORMATION ENGINEERING DESIGN SYMPOSIUM LA English DT Proceedings Paper CT IEEE Systems and Information Engineering Design Symposium CY APR 28, 2006 CL Charlottesville, VA SP IEEE AB In 2005, the Department of Defense completed its fifth round of Base Realignment and Closure (BRAC). This process involved analytically determining the military value (MV) of an installation and then ranking all installations based on MV scores. These rankings were used to determine which installations would be closed or realigned, subject to meeting minimum Army requirements for maintaining certain functions. In 2005, the MV score for an installation was derived as a weighted sum of the installation's score over a set of forty attributes. This paper describes the methods we used in analyzing these attributes, our goal being to identify the attributes that had the greatest impact on the installation rankings. From our analysis, we developed recommendations on which attributes should be kept for future BRAC proceedings, as well as those that could be considered for revision. C1 [Lee, Matthew; Noblin, Jack; Reynolds, Brian; Roberts, Brad] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Trainor, Timothy] US Mil Acad, Engn Management Program, West Point, NY 10996 USA. RP Lee, M (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM Timothy.Trainor@usma.edu FU Office of the Deputy Assistant Secretary of the Army for Infrastructure Analysis (DASA(IA)) FX This work was supported in part by the Office of the Deputy Assistant Secretary of the Army for Infrastructure Analysis (DASA(IA)). NR 11 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0473-5 PY 2006 BP 245 EP + DI 10.1109/SIEDS.2006.278684 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Transportation Science & Technology SC Computer Science; Engineering; Transportation GA BFW73 UT WOS:000245140100044 ER PT S AU Ballato, A AF Ballato, Arthur GP IEEE TI Elastic Moduli, and their Temperature Coefficients, of Piezoelectric and Nonpiezoelectric Polycrystalline Aggregates SO 2006 IEEE ULTRASONICS SYMPOSIUM, VOLS 1-5, PROCEEDINGS SE ULTRASONICS SYMPOSIUM LA English DT Proceedings Paper CT IEEE Ultrasonics Symposium CY OCT 03-06, 2006 CL Vancouver, CANADA SP IEEE DE piezoelectric; polycrystal; aggregate; elastic ID ALPHA-QUARTZ; CONSTANTS; CRYSTALS AB Classical procedures for computing average isotropic elastic moduli of polycrystalline aggregates are associated with the names of Voigt, Reuss, and Hill. The Voigt-Reuss-Hill (VRH) procedures apply to averaging moduli subject solely to mechanical boundary conditions. Piezoelectrics in general, are required to be characterized by both mechanical and electrical boundary conditions. This paper describes proper averaging for piezoelectrics, along with an advanced averaging method. Numerical values are provided for examples using materials with strong piezocoupling values. The examples demonstrate that the piezoelectric effect must be taken into account in the averaging process. Associated temperature coefficients of the elastic moduli are also supplied for some technologically important piezoelectric and nonpiezoelectric substances. C1 USA, Commun Elect Res Dev & Engn Ctr, AMSRD CER CS, Ft Monmouth, NJ 07703 USA. RP Ballato, A (reprint author), USA, Commun Elect Res Dev & Engn Ctr, AMSRD CER CS, Ft Monmouth, NJ 07703 USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1051-0117 BN 978-1-4244-0201-4 J9 ULTRASON PY 2006 BP 2250 EP 2253 DI 10.1109/ULTSYM.2006.568 PG 4 WC Acoustics; Engineering, Electrical & Electronic; Physics, Applied SC Acoustics; Engineering; Physics GA BIK54 UT WOS:000260407801174 ER PT S AU Li, H Abdi, A Bar-Ness, Y Su, W AF Li, Hong Abdi, Ali Bar-Ness, Yeheskel Su, Wei GP IEEE TI Carrier Frequency Offset Estimation in qHLRT Modulation Classifier with Antenna Arrays SO 2006 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE (WCNC 2006), VOLS 1-4 SE IEEE Wireless Communications and Networking Conference LA English DT Proceedings Paper CT IEEE Wireless Communications and Networking Conference CY APR 03-06, 2006 CL Las Vegas, NV SP IEEE ID PHASE AB A likelihood ratio test (LRT) -based modulation classifier is sensitive to unknown parameters, such as carrier frequency offset (CFO), symbol rate, etc. To deal with the limited knowledge of CFO, in this paper, a quasi-hybrid likelihood ratio test (qHLRT) -based approach is proposed for linear modulation classification. In the qHLRT algorithm, a non-maximum likelihood (ML) estimator is used to reduce the computational burden of multivariate maximization. Several of blind, non-ML CFO estimators are studied and their performance are compared with both single and multiple receiving antennas systems. It is shown that the nonlinear least-squares (NLS) CFO estimator is the best choice for the qHLRT algorithm, particularly with antenna arrays, which are introduced to combat the effect of channel fading on modulation classification. C1 [Li, Hong; Abdi, Ali; Bar-Ness, Yeheskel] New Jersey Inst Technol, Ctr Wireless Commun & Signal Proc Res, ECE Dept, Newark, NJ 07102 USA. [Su, Wei] US Army, RDECOM, CERDEC, Ft Monmouth, NJ 07703 USA. RP Li, H (reprint author), New Jersey Inst Technol, Ctr Wireless Commun & Signal Proc Res, ECE Dept, Newark, NJ 07102 USA. EM hl8@njit.edu; ali.abdi@njit.edu; yeheskel.barness@njit.edu NR 12 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1525-3511 BN 978-1-4244-0269-4; 978-1-4244-0270-0 J9 IEEE WCNC PY 2006 BP 1465 EP 1470 PG 6 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BTE80 UT WOS:000286659000245 ER PT S AU Liang, Y Kanapady, R Tamma, KK AF Liang, Yu Kanapady, Ramdev Tamma, Kumar K. GP IEEE Computer Society TI An efficient parallel finite-element-based domain decomposition iterative technique with polynomial preconditioning SO 2006 INTERNATIONAL CONFERENCE ON PARALLEL PROCESSING WORKSHOPS, PROCEEDINGS SE International Conference on Parallel Processing Workshops LA English DT Proceedings Paper CT 35th International Conference on Parallel Processing CY AUG 14-18, 2006 CL Columbus, OH SP Int Assoc Comp & Commun, Ohio State Univ DE GMRES; domain decomposition; distributed format; polynomial preconditioner; finite element; linear equations ID LINEAR-SYSTEMS AB An efficient parallel finite element-based non-overlapping domain decomposition iterative technique formulated with polynomial preconditioned GMRES method is presented. Unlike the standard row-oriented partitioning of a matrix, the finite element based domain decomposition solver with polynomial preconditioning circumvents the assembly of matrix, reordering of matrix, redundant computations associated with the interface elements, numerical problems associated with local pre-conditioner and costly global preconditioner construction. A dramatic reduction in parallel overhead both in terms of computation and communication results in a highly scalable solver The parallel performance results for large-scale static and dynamic problems on the IBM SP2 and the SGI Origin are presented. C1 [Liang, Yu; Kanapady, Ramdev; Tamma, Kumar K.] Univ Minnesota, Army High Performance Comp Res Ctr, Minneapolis, MN 55414 USA. RP Liang, Y (reprint author), Univ Minnesota, Army High Performance Comp Res Ctr, Minneapolis, MN 55414 USA. EM yliang@cs.umn.edu; ramdev@me.umn.edu; ktamma@tc.umn.edu NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 1530-2016 BN 0-7695-2637-3 J9 INT CONF PARA PROC PY 2006 BP 505 EP + PG 3 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Telecommunications SC Computer Science; Telecommunications GA BFB82 UT WOS:000240906500062 ER PT B AU Duggirala, R Lal, A Polcawich, RG Dubey, M AF Duggirala, Rajesh Lal, Amit Polcawich, Ronald G. Dubey, Madan GP IEEE TI CMOS compatible Multiple Power-Output MEMS Radioisotope mu-Power Generator SO 2006 INTERNATIONAL ELECTRON DEVICES MEETING, VOLS 1 AND 2 SE International Electron Devices Meeting LA English DT Proceedings Paper CT IEEE International Electron Devices Meeting CY DEC 11-13, 2006 CL San Francisco, CA SP IEEE AB We demonstrate a novel 6.6% high-efficiency CMOS compatible piezoelectric aluminum nitride (AlN) thin-film based Integrated P-Radioisotope-powered Electro-Mechanical Power Generator (IREMPG). We integrate silicon betavoltaics with radioisotope actuated piezoelectric unimorph converters to efficiently utilize both kinetic energy and charge of the emitted beta particles for electrical power generation. IREMPG has three output ports generating (1) a 2.8MHz pulse remotely detectable up to 6 feet, (2) a 2.95 mu W low-frequency pulse across 525k Omega, for 2s every 400s, at 4.4% efficiency, and (3) 400pW-700pW average continuous power across 33M Omega at 2.78% maximum efficiency. Individual IREMPGs can be arrayed in series or parallel configurations for higher power output, and used to power low-power sensor network nodes. C1 [Duggirala, Rajesh; Lal, Amit] Cornell Univ, Sch Elect & Comp Engn, Sonic MEMS Lab, Ithaca, NY 14853 USA. [Polcawich, Ronald G.; Dubey, Madan] US Army, Res Lab, Adelphi, MD USA. RP Duggirala, R (reprint author), Cornell Univ, Sch Elect & Comp Engn, Sonic MEMS Lab, Ithaca, NY 14853 USA. EM rd92@comell.edu FU DARPA-MTO under the RIMS program; U. S. Army Aviation and Missile Research, Development, and Engineering Center FX This work was supported by DARPA-MTO under the RIMS program, and contracted under the U. S. Army Aviation and Missile Research, Development, and Engineering Center. NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0438-4 J9 INT EL DEVICES MEET PY 2006 BP 242 EP + PG 2 WC Engineering, Electrical & Electronic; Physics, Condensed Matter SC Engineering; Physics GA BGI76 UT WOS:000247357700063 ER PT S AU Khalessi, MR Lin, HZ Kuper, RJ D'Angelo, A AF Khalessi, Mohammad R. Lin, Hong-Zong Kuper, Robert J. D'Angelo, Antony GP IEEE TI Emerging probabilistic technology and its application to reliability prediction and risk assessment SO 2006 PROCEEDINGS - ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM, VOLS 1 AND 2 SE Reliability and Maintainability Symposium LA English DT Proceedings Paper CT 52nd Annual Reliability and Maintainability Symposium CY JAN 23-26, 2006 CL Newport Beach, CA SP IEEE DE reliability; risk; liability; probabilistic; nondeterministic C1 [Khalessi, Mohammad R.; Lin, Hong-Zong] PredictionProbe Inc, 2192 Dupont Dr,Suite 205, Irvine, CA 92612 USA. [Kuper, Robert J.] US Army, ARDEC, Res Dev & Engn Command RDECOM, Picatinny Arsenal, NJ 07806 USA. [D'Angelo, Antony] US Army, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Khalessi, MR (reprint author), PredictionProbe Inc, 2192 Dupont Dr,Suite 205, Irvine, CA 92612 USA. EM mkhalessi@predictionprobe.com; hzlin@predictionprobe.com; robert.kuper@us.army.mil; andangel@pica.army.mil FU The Probabilistic Transient Dynamic Impact Analysis [PA103E2 IM]; U.S. Army AREC, Packaging Division, Picatinny Arsenal [DAAA21-94-C-1031] FX The Probabilistic Transient Dynamic Impact Analysis of PA103E2 IM Container was supported by the U.S. Army AREC, Packaging Division, Picatinny Arsenal, under contract DAAA21-94-C-1031. NR 21 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-144X BN 978-1-4244-0007-2 J9 P REL MAINT S PY 2006 BP 63 EP + DI 10.1109/RAMS.2006.1677351 PG 3 WC Computer Science, Software Engineering; Operations Research & Management Science; Statistics & Probability SC Computer Science; Operations Research & Management Science; Mathematics GA BGT51 UT WOS:000250419100011 ER PT B AU Kruus, P Sterne, D Gopaul, R Heyman, M Rivera, B Budulas, P Luu, B Johnson, T Ivanic, N Lawler, G AF Kruus, Peter Sterne, Dan Gopaul, Richard Heyman, Michael Rivera, Brian Budulas, Peter Luu, Brian Johnson, Tommy Ivanic, Natalie Lawler, Geoff GP IEEE TI In-band wormholes and countermeasures in OLSR networks SO 2006 SECURECOMM AND WORKSHOPS LA English DT Proceedings Paper CT 2nd International Conference on Security and Privacy in Communication Networks (SecureComm 2006) CY AUG 28-SEP 01, 2006 CL Baltimore, MD SP IEEE Commun Soc, Create Net DE computer network security; routing; mobile communications; reachability analysis; wormhole C1 [Kruus, Peter; Sterne, Dan; Heyman, Michael; Johnson, Tommy; Lawler, Geoff] Sparta Syst Inc, Laguna Hills, CA 92653 USA. [Gopaul, Richard; Rivera, Brian; Budulas, Peter; Luu, Brian; Ivanic, Natalie] US Army Res Lab, Adelphi, MD USA. RP Kruus, P (reprint author), Sparta Syst Inc, Laguna Hills, CA 92653 USA. EM peter.kruus@sparta.com; dan.sterne@sparta.com; rgopaul@arl.army.mil; brivera@arl.army.mil; pete@arl.army.mil FU U. S. Army Research Laboratory under the Collaborative Technology Alliance Program; Cooperative Agreement [DAAD19-01-2-0011] FX Prepared through collaborative participation in the Communications and Networks Consortium sponsored by the U. S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-0422-3 PY 2006 BP 232 EP + PG 2 WC Telecommunications SC Telecommunications GA BGF27 UT WOS:000246413900024 ER PT B AU Gupta, N Smith, D AF Gupta, Neelam Smith, Dale BE Bonneau, RJ TI A field-portable simultaneous dual-band infrared hyperspectral imager SO 34TH APPLIED IMAGERY AND PATTERN RECOGNITION WORKSHOP: MULTI-MODAL IMAGING LA English DT Proceedings Paper CT 34th Applied Imagery and Pattern Recognition Workshop (AIPR 2005) CY OCT 19-21, 2005 CL Washington, DC SP IEEE Comp Soc TCPAMI AB We report on the development and characterization of a field-portable hyperspectral imager designed to collect 128-band image cubes simultaneously in both the 4-5.25 mu m (mid wave infrared, MWIR) and 8-10.5 mu m (long wave infrared, LWIR) bands for defection of target as well as chemical/biological agents. The imager uses a specially designed diffractive optics Ge lens with a cooled dual-band 320x240 HgCdTe focal plane array. This lens performs both imaging and dispersive functions. The imager collects a single-color full scene image with a narrow band in the LWIR (e.g., at 8 mu m) using the first order diffraction and corresponding single-color image in the MWIR (4 mu m in this case) using the second order diffraction at the same time. Images at different wavelengths are obtained by moving the lens along its optical axis to focus the corresponding wavelengths. Here we will discuss the imager and present field test data and results. C1 [Gupta, Neelam; Smith, Dale] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ngupta@arl.army.mil RI Gupta, Neelam/B-8702-2013 NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 0-7695-2479-6 PY 2006 BP 87 EP + PG 2 WC Computer Science, Artificial Intelligence; Imaging Science & Photographic Technology SC Computer Science; Imaging Science & Photographic Technology GA BEK80 UT WOS:000237617100015 ER PT S AU Wong, EY AF Wong, Ernest Y. GP IEEE TI Work in progress: Project MathWORKS! Introducing operations research to high schools SO 36th Annual Frontiers in Education, Conference Program, Vols 1-4: BORDERS: INTERNATIONAL, SOCIAL AND CULTURAL SE PROCEEDINGS-FRONTIERS IN EDUCATION CONFERENCE LA English DT Proceedings Paper CT 36th Annual Frontiers in Education (FIE 2006) CY OCT 28-31, 2006 CL San Diego, CA SP Amer Soc Engn Educ, ERM Div, IEEE Comp Soc, IEEE Educ Soc, Univ San Diego, San Diego State Univ DE high school outreach; math education; operations research AB Project MathWORKS! reaches out to high school math and science instructors, introduces them to operations research methods that help solve real-world problems, and excites them into teaching math in ways that help improve student learning. Instructors and undergraduates at: the United States Military Academy conduct workshops that relate mathematical ideas to familiar context-such as reducing waiting time in a fast food restaurant, maximizing profit for a manufacturing company, or choosing of the most appropriate college upon graduating from high school - so that high school instructors can then incorporate the material into their classrooms. MathWORKS! seeks to introduce practical methods and tools that help promote the love of learning, dispel the notion that mathematics is incomprehensible, and empower teachers and students alike with the capacity and imagination to leverage math in the solution of everyday problems. In short, MathWORKS! aims to show that math does actually work. C1 US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Wong, EY (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0190-5848 BN 978-1-4244-0256-4 J9 PROC FRONT EDUC CONF PY 2006 BP 91 EP 92 PG 2 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Education & Educational Research; Education, Scientific Disciplines SC Computer Science; Education & Educational Research GA BGC22 UT WOS:000245981400020 ER PT S AU Wong, E Wolter, J Trainor, T AF Wong, Ernest Wolter, Jason Trainor, Timothy GP IEEE TI Work in progress: College faculty development systems engineering and the west point way SO 36TH ANNUAL FRONTIERS IN EDUCATION, CONFERENCE PROGRAM, VOLS 1-4: BORDERS: INTERNATIONAL, SOCIAL AND CULTURAL SE Frontiers in Education Conference LA English DT Proceedings Paper CT 36th Annual Frontiers in Education (FIE 2006) CY OCT 28-31, 2006 CL San Diego, CA SP Amer Soc Engn Educ, ERM Div, IEEE Comp Soc, IEEE Educ Soc, Univ San Diego, San Diego State Univ DE faculty development; systems engineering; undergraduate education; United States Military Academy AB Over half of the instructors at the United States Military Academy are rotating military faculty members who are officers in the U.S. Army. Most have obtained advanced degrees from some of the most prestigious universities in the nation and are obligated to teach three years at West Point. By virtue of their leadership experiences and educational qualifications, these officers constitute a valuable resource. They not only teach a majority of the cadets at West Point, but they also serve as exemplary role models for the cadets. However, exceptional military service and impeccable academic credentialing do not necessarily confirm that these officers will be knowledgeable and proficient undergraduate instructors. Therefore, prior to the start of each academic year the Department of Systems Engineering conducts a faculty development workshop aimed at ensuring rotating faculty members enter their first classroom assignments as capable, competent, and confident instructors. C1 [Wong, Ernest; Wolter, Jason; Trainor, Timothy] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Wong, E (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM ernest.wong@usma.edu; jason.wolter@us.army.mil; tim.trainor@usma.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0190-5848 BN 978-1-4244-0256-4 J9 PROC FRONT EDUC CONF PY 2006 BP 628 EP + PG 2 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Education & Educational Research; Education, Scientific Disciplines SC Computer Science; Education & Educational Research GA BGC22 UT WOS:000245981400154 ER PT S AU Cobb, M Giordan, J Cook, B AF Cobb, Michael Giordan, John Cook, Brad GP IEEE TI Work in progress: A comparison of assessment techniques. SO 36TH ANNUAL FRONTIERS IN EDUCATION, CONFERENCE PROGRAM, VOLS 1-4: BORDERS: INTERNATIONAL, SOCIAL AND CULTURAL SE Frontiers in Education Conference LA English DT Proceedings Paper CT 36th Annual Frontiers in Education (FIE 2006) CY OCT 28-31, 2006 CL San Diego, CA SP Amer Soc Engn Educ, ERM Div, IEEE Comp Soc, IEEE Educ Soc, Univ San Diego, San Diego State Univ DE course evaluation methods; programming; information technology AB First year cadets at the United States Military Academy are required to complete an introduction to computers and technology course. In the past, we assessed the student mastery of the basic programming concepts of sequence, selection, and iteration through large out-of-class projects. Recently, we redesigned the course assessment technique to replace the out-of-class projects with three in-class graded labs involving scaled down problems. Comparison of the results of term end exams and end-of-course surveys from cadets and faculty from both semesters indicate that the in-class graded labs are a better assessment technique. This paper discusses the implementation and results of the in class graded labs. C1 [Cobb, Michael; Giordan, John; Cook, Brad] US Mil Acad, West Point, NY 10996 USA. RP Cobb, M (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Michael-cobb@us.army.mil; john.giordano@usma.edu; brad.cook@usma.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0190-5848 BN 978-1-4244-0256-4 J9 PROC FRONT EDUC CONF PY 2006 BP 1204 EP + PG 2 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Education & Educational Research; Education, Scientific Disciplines SC Computer Science; Education & Educational Research GA BGC22 UT WOS:000245981400297 ER PT B AU Letherwood, MD Gunter, DD Gorsich, DJ AF Letherwood, Michael D. Gunter, David D. Gorsich, David J. BE Genco, A Gentile, A Sorce, S TI University centers of excellence for M&S in support of military systems SO 4th International Industrial Simulation Conference 2006 LA English DT Proceedings Paper CT 4th International Industrial Simulation Conference CY JUN 05-07, 2006 CL Univ Palermo, Palermo, ITALY SP AEKI, CREAX, Ghent Univ, ENSAIT, TU Ilmenau, ICAR CNR, UPV HO Univ Palermo AB The US Army vision, announced in October of 1999, encompasses people, readiness, and transformation. The goal of the Army vision is to transition the entire Army into a force that is strategically responsive and dominant at every point of the spectrum of operations. The Future Combat Systems (FCS] program is a joint DARPA/Army program' that is identifying the promising systems and technologies for achieving the Army's vision of fielding an "Objective Force" beginning this decade. The Objective Force is the Army's future full spectrum force; organized, manned, equipped and trained to be more strategically responsive, deployable, agile, versatile, lethal, survivable, and sustainable across the entire spectrum of military operations from major theater wars through counter terrorism to homeland security. This force will be lighter and more mobile and the Army transformation requirements include the ability to put a combat-capable brigade anywhere in the world within 96 hours, a full division in 120 hours, and five divisions on the ground within 30 days. The FCS is envisioned to be a versatile family of combat systems that represent the way the Army will fight wars in the future. The Army plans to field an integrated system of combat systems in blocks until full objective capability is realized to meet the goals of Army transformation. These systems will incorporate the latest technologies for mobility, lethality, sensor platforms, and survivability. The Tank Automotive Research, Development, and Engineering Center (TARDEC) has spearheaded these efforts by developing collaborative relationships with leading US universities to investigate and implement fostered research into the virtual prototyping process. The goal is to streamline and improve simulation-based design and analysis capabilities with special emphasis being placed on application to new and existing tactical wheeled and tracked vehicles. This paper will describe some of TARDEC's efforts to develop more robust, general purpose, analytical capabilities which will allow detailed investigation of a vehicle's synergistic dynamic performance. C1 USA, TARDEC, Warren, MI 48397 USA. RP Letherwood, MD (reprint author), USA, TARDEC, 6501 E 11 Mile Rd,MS 157, Warren, MI 48397 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU EUROSIS PI GHENT PA GHENT UNIV, COUPURE LINKS 653, GHENT, B-9000, BELGIUM BN 978-90-77381-26-7 PY 2006 BP 103 EP 107 PG 5 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA BFZ08 UT WOS:000245531000018 ER PT B AU Kurec, A Mabesa, JR AF Kurec, Aleksander Mabesa, Jose R., Jr. BE Genco, A Gentile, A Sorce, S TI Laboratory tools for use in simulation based development of advanced military run flat tire systems SO 4th International Industrial Simulation Conference 2006 LA English DT Proceedings Paper CT 4th International Industrial Simulation Conference CY JUN 05-07, 2006 CL Univ Palermo, Palermo, ITALY SP AEKI, CREAX, Ghent Univ, ENSAIT, TU Ilmenau, ICAR CNR, UPV HO Univ Palermo AB Recent advances in bulk material and material processing has lent itself to broader applications. The U.S. Army positions itself to leverage this technological advancement, and reap its benefits. Using the RDECOM-TARDEC's Ground Vehicle Simulation Laboratory (GVSL), research scientists and engineers are using these both physical and analytical tools to develop advanced military grade run flat tires for their vehicle platforms. Basic research development is conducted to adequately evaluate and optimize every design variable. To date, the U.S. Army is characterizing, modeling, simulating, and optimizing their prototype fielded design for the High Mobility Multipurpose Wheeled Vehicle (HMMWV) platform. In this paper, we will discuss the RDECOM-TARDEC GVSL's use of their advanced laboratory tools to develop an advanced military-grade run flat tire system. Utilizing partnerships with other government laboratories, academia, and private industry, the US Army research scientists and engineers will be able to provide the best run flat solution for their customer, the US Army Solider. C1 USA, TARDEC, RDECOM, Warren, MI 48397 USA. RP Kurec, A (reprint author), USA, TARDEC, RDECOM, AMSRD-TAR-N-157, Warren, MI 48397 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU EUROSIS PI GHENT PA GHENT UNIV, COUPURE LINKS 653, GHENT, B-9000, BELGIUM BN 978-90-77381-26-7 PY 2006 BP 123 EP 127 PG 5 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA BFZ08 UT WOS:000245531000021 ER PT B AU Lucero, A Cabrera, SD Vidal, E Aguirre, A AF Lucero, Aldo Cabrera, Sergio D. Vidal, Edward, Jr. Aguirre, Alberto GP IEEE Computer Society TI Residual coding of images for l-infinity control under the JPEG 2000 framework SO 7TH IEEE SOUTHWEST SYMPOSIUM ON IMAGE ANALYSIS AND INTERPRETATION LA English DT Proceedings Paper CT 7th IEEE Southwest Symposium on Image Analysis and Interpretation (SSIAI 2006) CY MAR 26-28, 2006 CL Denver, CO AB In this paper, the use of residual coding of images is investigated as a method for controlling maximum absolute error (MAE), or L-infinity distortion metric, in lossy image compression based almost 100% on the JPEG2000 framework. The images are lossy compressed at an Open Loop bit rate (ROI) using the JPEG2000 coder, and in order to obtain the residuals, images are decompressed at the encoder side. Uniform quantization of the residuals is used to control the achieved maximum absolute error. The quantized residuals are then coded losslessly using JPEG2000 with zero levels of wavelet decomposition, which is a direct application of EBCOT [1]. A small subset of the largest residuals (outliers) can be optionally coded separately. A comparison of two techniques used for selecting the best combination of Open Loop, EBCOT, and Outlier rates is presented. The images used in this study are bands extracted from hyperspectral data sets, for which the control of MAE is important. C1 [Lucero, Aldo; Cabrera, Sergio D.; Aguirre, Alberto] Univ Texas, Dept Elect & Comp Engn, El Paso, TX 79968 USA. [Vidal, Edward, Jr.] US Army, Res Lab, White Sands Missile Range, NM 88002 USA. RP Lucero, A (reprint author), Univ Texas, Dept Elect & Comp Engn, El Paso, TX 79968 USA. EM alucero@ece.utep.edu; cabrera@ece.utep.edu; develone@sbcglobal.net; albaguirre@gmail.com NR 7 TC 0 Z9 0 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 1-4244-0069-4 PY 2006 BP 223 EP + PG 2 WC Imaging Science & Photographic Technology SC Imaging Science & Photographic Technology GA BEG27 UT WOS:000237208000046 ER PT J AU Wambeke, BW Shield, CK AF Wambeke, BW Shield, CK TI Development length of glass fiber-reinforced polymer bars in concrete SO ACI STRUCTURAL JOURNAL LA English DT Article DE bonds fiber; polymer; reinforcement ID BOND AB Glass fiber-reinforced polymer (GFRP) reinforcing bars have become a viable option for reinforcement in concrete when corrosion is a concern. The objective of this research was to investigate the bond performance of GFRP reinforcing bars it? concrete, to evaluate. the existing ACl Committee 440 recommendations for development length of FRP bars it? concrete, and to develop new design recommendations if needed. An equation for the development length of GFRP reinforcing bars in concrete was formulated by applying a methodology similar to one used to create the development length equation for steel reinforcing bars. Data collected from beam-based bond tests in the literature were used to construct two equations for development length: one based on a splitting mode of failure and the other on a pullout mode of failure. The effects of bar diameter, bar tensile strength, concrete compressive strength, cover, and the presence of transverse reinforcement were investigated. The proposed equations appear to be a conservative yet reasonable means to calculate the development length of GFRP reinforcing bars in concrete given the available test data. The proposed equations arc compared to those found in ACl 440.1R-03 and the Japanese Design Guidelines. C1 US Mil Acad, West Point, NY 10996 USA. Univ Minnesota, Dept Civil Engn, Minneapolis, MN USA. RP Wambeke, BW (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 18 TC 26 Z9 28 U1 1 U2 6 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 USA SN 0889-3241 J9 ACI STRUCT J JI ACI Struct. J. PD JAN-FEB PY 2006 VL 103 IS 1 BP 11 EP 17 PG 7 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 027IJ UT WOS:000236408600002 ER PT J AU Wei, Q Jiao, T Ramesh, KT Ma, E Kecskes, LJ Magness, L Dowding, R Kazykhanov, VU Valiev, RZ AF Wei, Q Jiao, T Ramesh, KT Ma, E Kecskes, LJ Magness, L Dowding, R Kazykhanov, VU Valiev, RZ TI Mechanical behavior and dynamic failure of high-strength ultrafine grained tungsten under uniaxial compression SO ACTA MATERIALIA LA English DT Article DE tungsten; ultrafine microstructure; severe plastic deformation; strain rate sensitivity; flow softening ID SEVERE PLASTIC-DEFORMATION; ENERGY PENETRATOR MATERIALS; STRAIN-RATE; POLYCRYSTALLINE TUNGSTEN; SHEAR LOCALIZATION; SINGLE-CRYSTALS; METALS; TRANSITION; IRON; FLOW AB We have systematically investigated the quasi-static and dynamic mechanical behavior (especially dynamic failure) of ultra-fine grained (UFG) tungsten (W) under uniaxial compression. The starting material is of commercial purity and large grain size. We utilized severe plastic deformation to achieve the ultrafine microstructure characterized by grains and subgrains with sizes of similar to 500 nm, as identified by transmission electron microscopy. Results of quasi-static compression show that the UFG W behaves in an elastic-nearly perfect plastic manner (i.e., vanishing strain hardening), with its flow stress approaching 2 GPa, close to twice that of conventional coarse grain W. Post-mortem examinations of the quasi-statically loaded samples show no evidence of cracking, in sharp contrast to the behavior of conventional W (where axial cracking is usually observed). Under uniaxial dynamic compression (strain rate similar to 10(3)s(-1)), the true stress-true strain curves of the UFG W exhibit significant flow softening, and the peak stress is similar to 3 GPa. Furthermore, the strain rate sensitivity of the UFG W is reduced to half the value of the conventional W. Both in situ high-speed photography and post-mortem examinations reveal shear localization and as a consequence, cracking of the UFG W under dynamic uniaxial compression. These observations are consistent with recent observations on other body-centered cubic metals with nanocrystalline or ultrafine micro structures. The experimental results are discussed using existing models for adiabatic shear localization in metals. (c) 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. Johns Hopkins Univ, Ctr Adv Met & Ceram Syst, Baltimore, MD 21218 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Ufa State Aviat Tech Univ, Ufa 450000, Russia. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, 362,ERB, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Ma, En/A-3232-2010; Kecskes, Laszlo/F-6880-2014; Dowding, Robert/F-1469-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; Dowding, Robert/0000-0002-4763-2131 NR 57 TC 126 Z9 133 U1 5 U2 65 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD JAN PY 2006 VL 54 IS 1 BP 77 EP 87 DI 10.1016/j.actamat.2005.08.031 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 991AM UT WOS:000233784500008 ER PT B AU Liu, FS Shi, XQ Lin, ZY Thompson, A AF Liu, Fengshan Shi, Xiquan Lin, Zhongyan Thompson, Andrew BE Liu, F Nashed, Z NGuerekata, GM Pokrajac, D Qiao, Z Shi, X Xia, X TI Affine transformation method in automatic image registration SO Advances in Applied and Computational Mathematics LA English DT Proceedings Paper CT Applied Mathematics Summer Workshop CY AUG 18-20, 2005 CL Delaware State Univ, Dover, DE SP Dept Def HO Delaware State Univ DE surface filling; B-spline surface patching; convergent geometric continuity; polygonal mesh; quad partition; adaptive ratio compatibility condition AB Image registration is a fundamental task in image processing used to match two or more pictures taken, for example, at different times, from different sensors, or from different viewpoints. It arises from widespread scientific fields such as computer vision, medical image analysis, virtual reality, satellite data processing, surface matching, and so on. In this paper, we used affine transformation method to register images automatically. C1 Delaware State Univ, Dept Appl Math & Theoret Phys, Appl Math Res Ctr, Dover, DE 19901 USA. Delaware State Univ, Comp & Informat Syst Dept, Dover, DE 19901 USA. USA, Res Lab, AMSRL, Aberdeen Proving Ground, MD 21005 USA. RP Liu, FS (reprint author), Delaware State Univ, Dept Appl Math & Theoret Phys, Appl Math Res Ctr, 1200 N Dupont Hwy, Dover, DE 19901 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 1-60021-358-8 PY 2006 BP 133 EP 139 PG 7 WC Mathematics, Applied SC Mathematics GA BFC70 UT WOS:000241005300011 ER PT B AU Thompson, A AF Thompson, Andrew BE Liu, F Nashed, Z NGuerekata, GM Pokrajac, D Qiao, Z Shi, X Xia, X TI Coordinate adjustment based on range and angle measurements SO Advances in Applied and Computational Mathematics LA English DT Proceedings Paper CT Applied Mathematics Summer Workshop CY AUG 18-20, 2005 CL Delaware State Univ, Dover, DE SP Dept Def HO Delaware State Univ DE Nonlinear Least Square; Weighted Least Square; Distance Observation; Angle Observation; inner product measurement; pseudorange and GPS AB This paper demonstrates the procedure and extends the classes of sensors to those that provide inner product measurements. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Thompson, A (reprint author), USA, Res Lab, AMSRL WM BA BLDG 4600, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 1-60021-358-8 PY 2006 BP 213 EP 221 PG 9 WC Mathematics, Applied SC Mathematics GA BFC70 UT WOS:000241005300018 ER PT S AU McMillan, RW AF McMillan, RW BE Byrnes, J TI Terahertz imaging, millimeter-wave radar SO Advances in Sensing with Security Applications SE NATO Security Through Science Series A: Chemistry and Biology LA English DT Proceedings Paper CT Conference of the NATO Advanced-Study-Institute on Advances in Sensing with Security Applications CY JUL, 2005 CL Il Ciocco, ITALY SP NATO Adv Study Inst DE terahertz imaging; subwavelength imaging; millimeter-wave radar; atmospheric effects; terahertz sources; terahertz detectors ID FREQUENCY AB The millimeter wave (MMW) band of frequencies extends from 30 GHz to 300 GHz, with some fuzziness on both ends of this spectrum. The terahertz (THz) band extends from about 200 GHz to about 30 THz, despite the fact that the lower frequencies in this range are not strictly 10(12) Hz or higher. These bands axe also variously called submillimeter, far-infrared, and near-millimeter. In recent years, there has been some degree of hype associated with the capabilities of systems operating in these bands. Sometimes exorbitant claims have been made relative to the ability of these systems to see through walls, detect buried structures, and detect cancer cells, for example. In this chapter we shall examine some of these clams and assess their validity. We shall find that MMW and THz systems can do some amazing things, some of them not related to the above claims, and that there is substantial promise of even more interesting results. In this chapter we begin by discussing these atmospheric limitations, since they permeate the whole technology of MMW, sub-MMW, and THz technology. We then discuss MMW and THz sources, detectors, optics, and systems in separate sections. Finally, we present some results obtained using sensors operating in these bands. Perhaps the most interesting of these results demonstrate the capability to image objects at resolutions as good as lambda/100, where lambda is wavelength. These measurements show the connection between this sensor technology and applications to security. C1 USA, Space & Missile Def Command, Huntsville, AL USA. RP McMillan, RW (reprint author), USA, Space & Missile Def Command, Huntsville, AL USA. NR 27 TC 8 Z9 10 U1 1 U2 4 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4641 BN 1-4020-4284-1 J9 NATO SECURITY SCI A PY 2006 VL 2 BP 243 EP 268 PG 26 WC Chemistry, Analytical; Engineering, Multidisciplinary; Remote Sensing SC Chemistry; Engineering; Remote Sensing GA BEC96 UT WOS:000236847700011 ER PT S AU Zinober, A Shtessel, Y Fossas, E Olm, J Patterson, J AF Zinober, Alan Shtessel, Yuri Fossas, Enric Olm, Josep Patterson, Joe BE Edwards, C Colet, EF Fridman, L TI Nonminimum phase output tracking control strategies for DC-to-DC power converters SO ADVANCES IN VARIABLE STRUCTURE AND SLIDING MODE CONTROL SE Lecture Notes in Control and Information Sciences LA English DT Article; Proceedings Paper CT 8th IEEE International Workshop on Variable Structure Systems CY SEP, 2004 CL Vilanova, SPAIN SP IEEE ID SLIDING MODE CONTROL; SYSTEM CENTER C1 Univ Sheffield, Dept Appl Math, Sheffield S10 2TN, S Yorkshire, England. Univ Alabama, Dept Elect & Comp Engn, Huntsville, AL 35899 USA. Univ Politecn Cataluna, Inst Ind & Control Engn, E-08028 Barcelona, Spain. Univ Politecn Cataluna, Dept Appl Math 4, Barcelona 08034, Spain. USA, AMCOM, Redstone Arsenal, AL 35898 USA. RP Zinober, A (reprint author), Univ Sheffield, Dept Appl Math, Sheffield S10 2TN, S Yorkshire, England. EM a.zinober@sheffield.ac.uk; shtessel@ece.uah.edu; enric.fossas@upc.es; josep.olm@upc.es; Joe.Patterson@us.army.mil RI Olm, Josep M./F-3728-2016 OI Olm, Josep M./0000-0003-4925-9251 NR 24 TC 4 Z9 4 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0170-8643 BN 3-540-32800-9 J9 LECT NOTES CONTR INF PY 2006 VL 334 BP 447 EP 482 PG 36 WC Automation & Control Systems; Computer Science, Information Systems SC Automation & Control Systems; Computer Science GA BEJ96 UT WOS:000237496700020 ER PT S AU Weber, BA Penn, JA AF Weber, Bruce A. Penn, Joseph A. BE Henry, DJ TI Imaging sensor systems for air to ground surveillance - art. no. 62090K SO Airborne Intelligence, Surveillance, Reconnaissance (ISR) Systems and Applications III SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Airborne Intelligence, Surveillance, Reconnaissance (ISR) Systems and Applications III CY APR 19-20, 2006 CL Kissimmee, FL SP SPIE AB Automated aerial surveillance and detection of hostile ground events, and the tracking of the perpetrators have become of critical importance in the prevention and control of insurgent uprisings and the global war on terror. Yet a basic understanding of the limitations of sensor system coverage as a function of aerial platform position and attitude is often unavailable to program managers and system administrators. In an effort to better understand this problem we present some of the design tradeoffs for two applications: 1) a 360 degrees viewing focal-plane array sensor system modeled for low altitude aerostat applications, and 2) a fixed diameter area of constant surveillance modeled for high altitude fixed wing aircraft applications. Ground coverage requirement tradeoffs include the number of sensors, sensor footprint geometry, footprint coverage variability as a function of platform position and attitude, and ground surface modeling. Event location specification includes latitude, longitude, altitude for the pixel centroid and corners, and line-of-sight centroid range. C1 USA, Res Lab, Adelphi, MD USA. RP Weber, BA (reprint author), USA, Res Lab, Adelphi, MD USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6265-9 J9 P SOC PHOTO-OPT INS PY 2006 VL 6209 BP K2090 EP K2090 AR 62090K DI 10.1117/12.673122 PG 8 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BES15 UT WOS:000239241600017 ER PT S AU Kwon, H Nasrabadi, NM AF Kwon, Heesung Nasrabadi, Nasser M. BE Shen, SS Lewis, PE TI Kernel canonical correlation analysis for hyperspectral anomaly detection - art. no. 623303 SO Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XII Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XII CY APR 17-20, 2006 CL Kissimmee, FL ID IMAGERY; CLASSIFICATION; ALGORITHM AB In this paper, we present a kernel-based nonlinear version of canonical correlation analysis (CCA), so called kernel canonical correlation analysis (KCCA), for hyperspectral anomaly detection applications. CCA only measures linear dependency between two sets of signal vectors (target and background) ignoring higher order correlations crucial for distinguishing between man-made objects and background clutter. In order to exploit nonlinear correlations we implicitly map the two sets of data into a high dimensional feature space where correlations of nonlinear features extracted from the original data are exploited by a kernel function. A generalized eigenproblem is then formulated for KCCA. In this paper, both CCA and KCCA are applied to real hyperspectral images and detection performance of CCA and KCCA are compared to the well-known RX anomaly detection algorithm. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6289-6 J9 P SOC PHOTO-OPT INS PY 2006 VL 6233 BP 23303 EP 23303 AR 623303 DI 10.1117/12.664112 PN 1&2 PG 8 WC Instruments & Instrumentation; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Instruments & Instrumentation; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BES78 UT WOS:000239353500003 ER PT S AU Rosario, D AF Rosario, Dalton BE Shen, SS Lewis, PE TI Principle of indirect comparison (PIC): Simulation & analysis of PIC based anomaly detection in multispectral data - art. no. 623323 SO Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XII Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XII CY APR 17-20, 2006 CL Kissimmee, FL DE indirect comparison; hyperspectral anomaly detection; simulation ID HYPERSPECTRAL IMAGERY AB The Army has gained a renewed interest in hyperspectral (HS) imagery for military surveillance. As a result, a HS research team has been established at the Army Research Lab (ARL) to focus exclusively on the design of innovative algorithms for target detection in natural clutter. In 2005 at this symposium, we presented comparison performances between a proposed anomaly detector and existing ones testing real HS data. Herein, we present some insightful results on our general approach using analyses of statistical performances of an additional ARL anomaly detector testing 1500 simulated realizations of model-specific data to shed some light on its effectiveness. Simulated data of increasing background complexity will be used for the analysis, where highly correlated multivariate Gaussian random samples will model homogeneous backgrounds and mixtures of Gaussian will model non-homogeneous backgrounds. Distinct multivariate random samples will model targets, and targets will be added to backgrounds. The principle that led to the design of our detectors employs an indirect sample comparison to test the likelihood that local HS random samples belong to the same population. Let X and Y denote two random samples, and let Z = X U Y, where U denotes the union. We showed that X can be indirectly compared to Y by comparing, instead, Z to Y (or to X). Mathematical implementations of this simple idea have shown a remarkable ability to preserve performance of meaningful detections (e.g., full-pixel targets), while significantly reducing the number of meaningless detections (e.g., transitions of background regions in the scene). C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Rosario, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6289-6 J9 P SOC PHOTO-OPT INS PY 2006 VL 6233 BP 23323 EP 23323 AR 623323 DI 10.1117/12.666081 PN 1&2 PG 11 WC Instruments & Instrumentation; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Instruments & Instrumentation; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BES78 UT WOS:000239353500072 ER PT S AU Tates, M Nasrabadi, N Kwon, H White, C AF Tates, Maria Nasrabadi, Nasser Kwon, Heesung White, Carl BE Zelnio, EG Garber, FD TI Wiener filter-based change detection for SAR imagery - art. no. 62370N SO Algorithms for Synthetic Aperture Radar Imagery XIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Algorithms for Synthetic Aperture Radar Imagery XIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE change detection; SAR AB In this paper we propose a Wiener filter-based change detection algorithm for the detection of mines in Synthetic Aperture Radar (SAR) imagery. By computing second order statistics, the Wiener filter-based method has demonstrated improved performance over Euclidean distance. It is more robust to the presence of highly correlated speckle noise, misregistration errors, and nonlinear variations in the two SAR scenes. These variations may result from differences in the data acquisition systems and varying conditions during the different data collect times. A method very similar to the Mahalanobis distance was also implemented to detect mines in SAR images and has shown similar performance to the Wiener filter-based method. We present results in the form of receiver operating characteristics (ROC) curves, comparing simple Euclidean difference change detection, Mahalanobis difference-based change detection, and the proposed Wiener filter-based change detection in both global and local implementations. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Tates, M (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6293-4 J9 P SOC PHOTO-OPT INS PY 2006 VL 6237 BP N2370 EP N2370 AR 62370N DI 10.1117/12.665945 PG 8 WC Imaging Science & Photographic Technology SC Imaging Science & Photographic Technology GA BEX14 UT WOS:000239925300021 ER PT J AU Funkhouser, TA Carr, WW AF Funkhouser, TA Carr, WW TI A 34-year-old man with chronic itching and peripheral and submucosal eosinophilia SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article ID STRONGYLOIDES-STERCORALIS INFECTION; ACUTE-INFLAMMATION; LEUKOCYTES; BEHAVIOR; PATIENT; DISEASE AB A 34-year-old man with peripheral eosinophilia, chronic pruritus, and colonic eosinophilic infiltration is presented as a patient-oriented problem-solving case report to show the important aspects of differential and specific diagnosis, treatment, prognosis, and caveats in the approach to the workup of the patient with eosinophilia. Allergic rhinitis, asthma, atopy, and drug-induced eosinophilia should come to mind in the initial differential diagnosis of any patient with peripheral eosinophilia. Also included in the differential after allergic disease processes would be the general categories of infectious, neoplastic, and the various forms of organ-specific eosinophilic infiltration and idiopathic syndromes. The importance of ruling out infectious causes for eosinophilia is paramount, especially given the dangers of immunosuppressive treatments often used to treat other conditions associated with eosinophilia. C1 Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC USA. RP Funkhouser, TA (reprint author), William Beaumont Army Med Ctr, Dept Allergy Immunol, 5005 N Piedras, El Paso, TX 79920 USA. EM todd.funkhouser@am.edd.army.mil NR 26 TC 3 Z9 4 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD JAN-FEB PY 2006 VL 27 IS 1 BP 77 EP 81 PG 5 WC Allergy SC Allergy GA 021GB UT WOS:000235970600015 PM 16598998 ER PT J AU Mikita, CP Mikita, JA AF Mikita, CP Mikita, JA TI Allergic bronchopulmonary aspergillosis SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article ID CYSTIC-FIBROSIS; ITRACONAZOLE AB A case of allergic bronchopulmonary aspergillosis (ABPA) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. ABPA is a hypersensitivity response to Aspergillus antigens in the lung and is distinct from other forms of Aspergillus pulmonary disease. Episodic bronchospasm, expectoration of mucous plugs, and fleeting pulmonary infiltrates are common manifestations of the disease. Several diagnostic schemes for ABPA have been described with varying criteria, which uniformly includes asthma and positive immediate skin-prick test to Aspergillus fumigatus. The mainstay of treatment for ABPA is corticosteroids, which are normally effective. C1 Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pulm, Washington, DC USA. Walter Reed Army Med Ctr, Dept Crit Care, Washington, DC USA. Walter Reed Army Med Ctr, Dept Sleep Med Serv, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Mikita, CP (reprint author), Walter Reed Army Med Ctr, Dept Allergy & Immunol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM cecilia.mikita@amedd.army.mil NR 12 TC 3 Z9 4 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD JAN-FEB PY 2006 VL 27 IS 1 BP 82 EP 84 PG 3 WC Allergy SC Allergy GA 021GB UT WOS:000235970600016 PM 16598999 ER PT J AU Dobak, WA AF Dobak, William A. TI Living with strangers: The nineteenth-century Sioux and the Canadian-American borderlands. SO AMERICAN INDIAN CULTURE AND RESEARCH JOURNAL LA English DT Book Review C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Dobak, WA (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU U C L A, AMER INDIAN STUDIES CENTER PI LOS ANGELES PA 3220 CAMPBELL HALL, BOX 951548, LOS ANGELES, CA 90095-1548 USA SN 0161-6463 J9 AM INDIAN CULT RES J JI Am. Indian Cult. Res. J. PY 2006 VL 30 IS 4 BP 160 EP 162 PG 3 WC History SC History GA 133PE UT WOS:000244024000017 ER PT J AU Burtis, MT AF Burtis, MT TI "Epidural" vertebral venous plexus - Reply SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Letter C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Burtis, MT (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JAN PY 2006 VL 27 IS 1 BP 7 EP 7 PG 1 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 004VC UT WOS:000234779600006 ER PT J AU Bui-Mansfield, LT AF Bui-Mansfield, LT TI Top 100 cited AJR articles at the AJR's centennial SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE AJR centennial; education; history; publishing; research ID NEEDLE ASPIRATION BIOPSY; GADOLINIUM-DTPA COMPLEX; COMPUTED-TOMOGRAPHY; PULMONARY-EMBOLISM; RADIATION-THERAPY; ABDOMINAL ABSCESSES; DIGITAL SUBTRACTION; ARTERIAL OCCLUSIONS; CONTRAST-MEDIA; MR-ANGIOGRAPHY C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Wake Forest Univ, Sch Med, Dept Radiol, Winston Salem, NC 27157 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 103 TC 11 Z9 11 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JAN PY 2006 VL 186 IS 1 BP 3 EP 6 DI 10.2214/AJR.05.1186 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 998NY UT WOS:000234327000003 PM 16357369 ER PT J AU Kirkpatrick, A Reed, CM Bui-Mansfield, LT Russell, MJ Whitford, W AF Kirkpatrick, A Reed, CM Bui-Mansfield, LT Russell, MJ Whitford, W TI Endometriosis of the canal of nuck SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE canal of nuck; endometriosis; genitourinary tract imaging; MRI; PET C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Wake Forest Univ, Dept Radiol, Winston Salem, NC 27157 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 5 TC 12 Z9 12 U1 0 U2 2 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JAN PY 2006 VL 186 IS 1 BP 56 EP 57 DI 10.2214/AJR.05.0739 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 998NY UT WOS:000234327000013 PM 16357379 ER PT J AU Ellis, RD Fukuda, MM McDaniel, P Welch, K Nisalak, A Murray, CK Gray, MR Uthaimongkol, N Buathong, N Sriwichai, S Phasuk, R Yingyuen, K Mathavarat, C Miller, RS AF Ellis, RD Fukuda, MM McDaniel, P Welch, K Nisalak, A Murray, CK Gray, MR Uthaimongkol, N Buathong, N Sriwichai, S Phasuk, R Yingyuen, K Mathavarat, C Miller, RS TI Causes of fever in adults on the Thai-Myanmar border SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID BLOOD-STREAM INFECTIONS; LABORATORY DIAGNOSIS; DEVELOPING-COUNTRIES; FEBRILE ILLNESSES; VIRUS-INFECTION; TYPHOID-FEVER; SCRUB TYPHUS; LEPTOSPIROSIS; DENGUE; RICKETTSIOSES AB A hospital-based study was conducted along the Thai-Myanmar border to provide greater knowledge of the causes of febrile illness and to determine what zoonotic and vector-borne emerging infectious diseases might be present. A total of 613 adults were enrolled from June 1999 to March 2002. Cases were classified based on clinical findings and laboratory results. An etiologic diagnosis was made for 48% of subjects. Malaria was the most common diagnosis, accounting for 25% of subjects, with two-thirds Plasmodium falciparum. Serologic evidence for leptospirosis was found in 17% of subjects. Other etiologic diagnoses included rickettsial infections, dengue fever, and typhoid. The most frequent clinical diagnoses were nonspecific febrile illness, respiratory infections, and gastroenteritis. Clinical associations were generally not predictive of etiologic diagnosis. Apparent dual diagnoses were common, particularly for malaria and leptospirosis. Findings have been used to modify treatment of unspecified febrile illness in the area. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Kwai River Christian Hosp, Sangkhlaburi, Thailand. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. VETCOM, Leptospirosis Referencee, Ft Sam Houston, TX 78234 USA. RP Ellis, RD (reprint author), 2530 N 24th St, Arlington, VA 22207 USA. EM schwartzellis@hotmail.com; mark.fukuda@afrims.org RI Valle, Ruben/A-7512-2013 NR 30 TC 42 Z9 43 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2006 VL 74 IS 1 BP 108 EP 113 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 002OV UT WOS:000234621800017 PM 16407353 ER PT J AU Wernette, DP Swearingen, CB Cropek, DM Lu, Y Sweedler, JV Bohn, PW AF Wernette, DP Swearingen, CB Cropek, DM Lu, Y Sweedler, JV Bohn, PW TI Incorporation of a DNAzyme into Au-coated nanocapillary array membranes with an internal standard for Pb(II) sensing SO ANALYST LA English DT Article ID ANODIC-STRIPPING VOLTAMMETRY; ATOMIC-ABSORPTION-SPECTROMETRY; NANOFILTRATION MEMBRANES; EMISSION-SPECTROMETRY; BIOLOGICAL CHEMISTRY; FLUORESCENT SENSORS; DRINKING-WATER; LEAD; DNA; GOLD AB A Pb(II)-specific DNAzyme has been successfully incorporated into Au-coated polycarbonate track-etched (PCTE) nanocapillary array membranes (NCAMs) by thiol-gold immobilization. Incorporation of the DNAzyme into the membrane provides a substrate-bound sensor using a novel internal control methodology for fluorescence-based detection of Pb(II). A non-cleavable substrate strand, identical to the cleavable DNAzyme substrate strand except the RNA-base is replaced by the corresponding DNA-base, is used for ratiometric comparison of intensities. The cleavable substrate strand is labeled with fluorescein, and the non-cleavable strand is labeled with a red fluorophore (Cy5 or Alexa 546) for detection after release from the membrane surface. This internal standard based ratiometric method allows for real-time monitoring of Pb(II)-induced cleavage, as well as standardizing variations in substrate size, solution detection volume, and monolayer density. The result is a Pb(II)-sensing structure that can be stored in a prepared state for 30 days, regenerated after reaction, and detect Pb(II) concentrations as low as 17 nM (3.5 ppb). C1 Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. Univ Illinois, Dept Chem, Urbana, IL 61801 USA. Construct Engn Res Lab, Champaign, IL 61822 USA. RP Lu, Y (reprint author), Univ Illinois, Beckman Inst Adv Sci & Technol, 600 S Mathews Ave, Urbana, IL 61801 USA. EM yi-lu@uiuc.edu; jsweedle@uiuc.edu; pbohn@uiuc.edu RI Lu, Yi/B-5461-2010; Sweedler, Jonathan/A-9405-2009 OI Lu, Yi/0000-0003-1221-6709; Sweedler, Jonathan/0000-0003-3107-9922 NR 45 TC 52 Z9 53 U1 3 U2 28 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0003-2654 J9 ANALYST JI Analyst PY 2006 VL 131 IS 1 BP 41 EP 47 DI 10.1039/b510071b PG 7 WC Chemistry, Analytical SC Chemistry GA 995JG UT WOS:000234096000006 PM 16365661 ER PT J AU Hybarger, G Bynum, J Williams, RF Valdes, JJ Chambers, JP AF Hybarger, G Bynum, J Williams, RF Valdes, JJ Chambers, JP TI A microfluidic SELEX prototype SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE SELEX; microfluidic; miniaturized; aptamer; prototype ID POLYMERASE-CHAIN-REACTION; ON-CHIP; NUCLEIC-ACIDS; MICROCHIP; SELECTION; ASSAYS; ELECTROPHORESIS; PLATFORMS; MOLECULES; APTAMERS AB Aptamers are nucleic acid binding species capable of recognizing a wide variety of targets ranging from small organic molecules to supramolecular structures, including organisms. They are isolated from combinatorial libraries of synthetic nucleic acid by an iterative process referred to as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). Here we describe an automated microfluidic, microline-based assembly that uses LabView-controlled actuatable valves and a PCR machine, and which is capable of the selection and synthesis of an anti-lysozyme aptamer as verified by sequence analysis. The microfluidic prototype described is 1) a simple apparatus that is relatively inexpensive to assemble, making automated aptamer selection accessible to many investigators, and 2) useful for the continued "morphing" of macro -> meso -> microfabricated structures until a convergence to a few functional systems evolves and emerges, partly or completely achieving simpler, smaller and more rapid SELEX applications. C1 Univ Texas, Dept Biol, San Antonio, TX 78249 USA. USA, RDECOM, ECBC, AMSSB,RRT, Aberdeen Proving Ground, MD 21010 USA. RP Chambers, JP (reprint author), Univ Texas, Dept Biol, 6900 N Loop,1604 W, San Antonio, TX 78249 USA. EM james.chambers@utsa.edu FU NIGMS NIH HHS [3S06GM 008194-25S1] NR 24 TC 46 Z9 59 U1 6 U2 25 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JAN PY 2006 VL 384 IS 1 BP 191 EP 198 DI 10.1007/s00216-005-0089-3 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 007NM UT WOS:000234976400030 PM 16315013 ER PT J AU Koenig, KL Hatchett, RJ Mettler, FA Goans, RE Schumacher, TA Noji, EK Jarrett, DG AF Koenig, KL Hatchett, RJ Mettler, FA Goans, RE Schumacher, TA Noji, EK Jarrett, DG TI Use high awareness and judgment to screen emergency department patients for radiation exposure SO ANNALS OF EMERGENCY MEDICINE LA English DT Letter C1 Univ Calif Irvine, Dept Emergency Med, Sch Med, Orange, CA 92668 USA. NIAID, Div Allergy Immunol & Transplantat, NIH, Bethesda, MD 20892 USA. New Mexico Fed Reg Med Ctr, Dept Radiol, Albuquerque, NM USA. Tulane Univ, Sch Publ Hlth & Trop Med, MJW Corp, Clinton, TN USA. Richard L Roudebush VA Med Ctr, VA Med Emergency Radiol Response Team, Indianapolis, IN USA. Dept Homeland Secur, Washington, DC USA. Uniformed Serv Univ Hlth Sci, USA, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. RP Koenig, KL (reprint author), Univ Calif Irvine, Dept Emergency Med, Sch Med, Orange, CA 92668 USA. NR 2 TC 1 Z9 1 U1 0 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JAN PY 2006 VL 47 IS 1 BP 120 EP 121 DI 10.1016/j.annemergmed.2005.08.032 PG 2 WC Emergency Medicine SC Emergency Medicine GA 001OO UT WOS:000234546400028 ER PT S AU Perovich, DK AF Perovich, Donald K. BE Langhorne, P Squire, V TI The interaction of ultraviolet light with Arctic sea ice during SHEBA SO Annals of Glaciology, Vol 44, 2006 SE ANNALS OF GLACIOLOGY LA English DT Proceedings Paper CT International Symposium on Sea Ice CY DEC 05-09, 2005 CL Dunedin, NEW ZEALAND SP Int Glaciol Soc, Univ Otago, Natl Inst Water & Atmospher Res, Royal Soc New Zealand ID RADIATIVE-TRANSFER; THEORETICAL-MODEL; MASS-BALANCE; TRANSMISSION; ALGAE; PHYTOPLANKTON; OCEAN AB The reflection, absorption and transmission of ultraviolet light by a sea-ice cover strongly impacts primary productivity, higher trophic components of the food web, and humans. Measurements of the incident irradiance at 305, 320, 340 and 380 nm and of the photosynthetically active radiation were made from April through September 1998 as part of the SHEBA (Surface Heat Budget of the Arctic Ocean program) field experiment in the Arctic Ocean. in addition, observations of snow depth and ice thickness were made at more than 100 sites encompassing a comprehensive range of conditions. The thickness observations were combined with a radiative transfer model to compute a time series of the ultraviolet light transmitted by the ice cover from April through September. Peak values of incident ultraviolet irradiance occurred in mid-June. Peak transmittance was later in the summer at the end of the melt season when the snow cover had completely melted, the ice had thinned and pond coverage was extensive. The fraction of the incident ultraviolet irradiance transmitted through the ice increased by several orders of magnitude as the melt season progressed. Ultraviolet transmittance was approximately a factor of ten greater for melt ponds than bare ice. Climate change has the potential to alter the amplitude and timing of the annual albedo cycle of sea ice. If the onset of melt occurs at increasingly earlier dates, ultraviolet transmittance will be significantly enhanced, with potentially deleterious biological impacts. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 29 TC 9 Z9 9 U1 0 U2 7 PU INT GLACIOLOGICAL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE CB2 1ER, ENGLAND SN 0260-3055 BN 978-0-946417-39-1 J9 ANN GLACIOL PY 2006 VL 44 BP 47 EP 52 DI 10.3189/172756406781811330 PG 6 WC Geochemistry & Geophysics; Geosciences, Multidisciplinary; Oceanography SC Geochemistry & Geophysics; Geology; Oceanography GA BGG56 UT WOS:000246685800008 ER PT S AU Perovich, D Richter-Menge, JA AF Perovich, Don Richter-Menge, Jacqueline A. BE Langhorne, P Squire, V TI From points to Poles: extrapolating point measurements of sea-ice mass balance SO ANNALS OF GLACIOLOGY, VOL 44, 2006 SE Annals of Glaciology-Series LA English DT Proceedings Paper CT International Symposium on Sea Ice CY DEC 05-09, 2005 CL Dunedin, NEW ZEALAND SP Int Glaciol Soc, Univ Otago, Natl Inst Water & Atmospher Res, Royal Soc New Zealand ID ARCTIC-OCEAN; INTERANNUAL VARIABILITY; TEMPORAL EVOLUTION; COVER; EXTENTS; TRENDS; SHEBA AB The amount of ice growth and ablation are key measures of the thermodynamic state of the ice cover. While ice extent and even ice thickness can be determined using remote-sensing techniques, this is not the case for the mass balance. Mass-balance measurements require an ability to attribute the change, establishing whether a change in the thickness of the ice cover occurs at the top or bottom surface and whether it is a result of growth or ablation. We have developed and implemented a tool that can be used to measure thermodynamic changes in sea-ice mass balance at individual locations: the ice mass-balance buoy (IMB). The primary limitation of the IMB is that it provides a point measurement of the ice mass balance, defined by a particular combination of snow and ice conditions. Determining if, and how, such point measurements can be extrapolated is critical to understanding the large-scale mass balance of the sea-ice cover. We explore the potential for extrapolation using mass-balance observations from the Surface Heat Budget of the Arctic (SHEBA) field experiment. During SHEBA, mass-balance measurements were made at over 100 sites covering a 100km(2) area. Results indicate that individual point measurements can provide reasonable estimates for undeformed and unponded multi-year ice, which represented more than two-thirds of the ice cover at SHEBA and is the dominant ice type in the perennial pack. A key is carefully selecting a representative location for the instrument package. The contribution of these point measurements can be amplified by integrating them with other tools designed to measure ice thickness and assimilating these combined data into sea-ice models. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Perovich, D (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM donald.k.perovich@erdc.usace.army.mil NR 23 TC 9 Z9 12 U1 0 U2 2 PU INT GLACIOLOGICAL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE CB2 1ER, ENGLAND SN 0260-3055 BN 978-0-946417-39-1 J9 ANN GLACIOL-SER PY 2006 VL 44 BP 188 EP 192 DI 10.3189/172756406781811204 PG 5 WC Geochemistry & Geophysics; Geosciences, Multidisciplinary; Oceanography SC Geochemistry & Geophysics; Geology; Oceanography GA BGG56 UT WOS:000246685800030 ER PT S AU Richter-Menge, JA Perovich, DK Elder, BC Claffey, K Rigor, I Ortmeyer, M AF Richter-Menge, Jacqueline A. Perovich, Donald K. Elder, Bruce C. Claffey, Keran Rigor, Ignatius Ortmeyer, Mark BE Langhorne, P Squire, V TI Ice mass-balance buoys: a tool for measuring and attributing changes in the thickness of the Arctic sea-ice cover SO ANNALS OF GLACIOLOGY, VOL 44, 2006 SE Annals of Glaciology-Series LA English DT Proceedings Paper CT International Symposium on Sea Ice CY DEC 05-09, 2005 CL Dunedin, NEW ZEALAND SP Int Glaciol Soc, Univ Otago, Natl Inst Water & Atmospher Res, Royal Soc New Zealand ID VARIABILITY; OCEAN; TEMPERATURE; EXTENTS; TRENDS; RECORD AB Recent observational and modeling studies indicate that the Arctic sea-ice cover is undergoing significant climate-induced changes, affecting both its extent and thickness. The thickness or, more precisely, the mass balance of the ice cover is a key climate-change indicator since it is an integrator of both the surface heat budget and the ocean heat flux. Accordingly, efforts are underway to develop and deploy in situ observing systems which, when combined with satellite remote-sensing information and numerical models, can effectively monitor and attribute changes in the mass balance of the Arctic sea-ice cover. As part of this effort, we have developed an autonomous ice mass-balance buoy (IMB), which is equipped with sensors to measure snow accumulation and ablation, ice growth and melt, and internal ice temperature, plus a satellite transmitter. The IMB is unique in its ability to determine whether changes in the thickness of the ice cover occur at the top or bottom of the ice cover, and hence provide insight into the driving forces behind the change. Since 2000, IMBs have been deployed each spring from the North Pole Environmental Observatory and in several other areas, including a few in the Beaufort Sea and Central Basin. At this point, the collective time series is too short to draw significant and specific conclusions regarding interannual and regional variability in ice mass balance. Comparisons of available data indicate that ice surface ablation is greater in the Beaufort region (67-80 cm), relative to the North Pole (0-30 cm), consistent with a longer period of melt in the more southerly location. Ablation at the bottom of the ice (22 cm), maximum ice thickness (235 cm) and maximum snow depth (28 cm) were comparable in the two regions. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Richter-Menge, JA (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jacqueline.A.Richter-Menge@erdc.usace.army.mil NR 23 TC 43 Z9 47 U1 0 U2 7 PU INT GLACIOLOGICAL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE CB2 1ER, ENGLAND SN 0260-3055 BN 978-0-946417-39-1 J9 ANN GLACIOL-SER PY 2006 VL 44 BP 205 EP 210 DI 10.3189/172756406781811727 PG 6 WC Geochemistry & Geophysics; Geosciences, Multidisciplinary; Oceanography SC Geochemistry & Geophysics; Geology; Oceanography GA BGG56 UT WOS:000246685800033 ER PT J AU Udeinya, IJ Brown, N Shu, EN Udeinya, FI Quakeyie, I AF Udeinya, IJ Brown, N Shu, EN Udeinya, FI Quakeyie, I TI Fractions of an antimalarial neem-leaf extract have activities superior to chloroquine, and are gametocytocidal SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID MALARIA; CULTURE AB The antimalarial activities of two fractions (IRDN-A and IRDN-B) of an extract from the leaves of the neem tree (Azadirachta indica) were compared with those of chloroquine, in in-vitro assays against Plasmodium falciparum. The asexual stages of a chloroquine-sensitive clone (ITG2F6) and a chloroquine-resistant isolate (W2) and the gametocytes of the NF 54 (BD-7) isolate of R falciparum were used as the drug targets. Activity against the asexual stages was generally evaluated as the concentrations inhibiting the parasitaemias recorded in the control cultures, after an incubation of 48-72 h, by 50% (IC50) or 100% (IC100). For the ITG2F6 strain, the IC50 and IC100 (in mu g/ml) were, respectively, 10(-5) and 10(-4) for IRDN-A, 10(-3) and 10(-2) for IRDN-B, and 10(-2) and 1.0 for chloroquine. The corresponding values for the W2 strain were 10(-5) and 1.0 for IRDN-A, and 10.0 and >100 for chloroquine (even at 100 mu g/ml, chloroquine only inhibited the parasitaemia by 85%). Each of the two neem-leaf fractions lysed 50% and 100% of developing gametocytes, at 10(-3) and 1.0 mu g/ml, respectively; and 50% and 100% of mature gametocytes at 10(-3) and 10(2) mu g/ml, respectively. If they are found safe and effective in vivo, the neem-leaf fractions may form the basis of new antimalarial drugs that not only cure chloroquine-sensitive and chloroquine-resistant malaria but also markedly reduce transmission. C1 Univ Nigeria, Coll Med, Dept Pharmacol & Therapeut, Enugu, Nigeria. Howard Univ, Coll Med, Dept Pharmacol, Washington, DC 20059 USA. Walter Reed Army Med Ctr, Dept Biochem, Washington, DC 20307 USA. Univ Nigeria, Coll Med, Dept Med Lab Sci, Enugu, Nigeria. Georgetown Univ, Dept Parasitol, Washington, DC 20057 USA. RP Shu, EN (reprint author), Univ Nigeria, Coll Med, Dept Pharmacol & Therapeut, Enugu Campus, Enugu, Nigeria. EM enshu1@yahoo.com NR 13 TC 12 Z9 12 U1 0 U2 0 PU MANEY PUBLISHING PI LEEDS PA HUDSON RD, LEEDS LS9 7DL, ENGLAND SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD JAN PY 2006 VL 100 IS 1 BP 17 EP 22 DI 10.1179/136485906X78508 PG 6 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA 008WV UT WOS:000235072300004 PM 16417709 ER PT S AU Cook, JL Ramirez-Marquez, JE AF Cook, Jason L. Ramirez-Marquez, Jose Emmanuel GP IEEE TI Capacitated reliability for Ad-hoc networks SO ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM, 2007 PROCEEDINGS SE Reliability and Maintainability Symposium LA English DT Proceedings Paper CT 53rd Annual Reliability and Maintainability Symposium (RAMS) CY JAN 22-25, 2007 CL Orlando, FL DE network reliability; Monte Carlo simulation; ad hoc networks AB Ad-hoc networking is used because of its malleable topology. The absence of infrastructure allows for the hasty deployment and redeployment of a network. No preparation of the coverage area is needed because things like transmission towers or communication wire lines are not necessary. It is this distinctive attribute of ad-hoc networking that does not conform to the base assumption on which all current network reliability methods are founded; that connectivity is known a priori. The proliferation of Ad-hoc Networking warrants new network reliability methods that may be applied to analyze them. This paper describes the unique characteristics of ad-hoc networks, presents current research on ad-hoc networks, and presents a new method for approximating the reliability of an ad-hoc network which is capacity constrained. C1 [Cook, Jason L.] USA, Quality Engn & Syst Assurance Directorate, ARDEC, Bldg 62 N, Picatinny Arsenal, NJ 07806 USA. [Ramirez-Marquez, Jose Emmanuel] Stevens Inst Technol, Picatinny Arsenal, NJ USA. RP Cook, JL (reprint author), USA, Quality Engn & Syst Assurance Directorate, ARDEC, Bldg 62 N, Picatinny Arsenal, NJ 07806 USA. EM Jason.Cook1@us.army.mil; jmarquez@stevens.edu NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-144X BN 978-0-7803-9766-8 J9 P REL MAINT S PY 2006 BP 192 EP + PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BGS99 UT WOS:000250381800034 ER PT J AU Sponsel, W Chen, N Dang, D Paris, G Graybill, J Najvar, LK Zhou, L Lam, KW Glickman, R Scribbick, F AF Sponsel, W Chen, N Dang, D Paris, G Graybill, J Najvar, LK Zhou, L Lam, KW Glickman, R Scribbick, F TI Topical voriconazole as a novel treatment for fungal keratitis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PAECILOMYCES-LILACINUS; INVASIVE ASPERGILLOSIS; LIQUID-CHROMATOGRAPHY; ANTIFUNGAL AGENT; THERAPY; PLASMA AB Paecilomyces lilacinus is a fungal pathogen which is generally resistant to amphotericin B and certain other antifungals and is an uncommon cause of devastating fungal keratitis. In the present studies, we evaluated topical voriconazole as therapy for P. lilacinus keratitis in rabbits. Thirty eyes of 15 rabbits were studied. In five animals, the uninfected left eye was treated twice daily with voriconazole (drug control, uninfected eye). In these same animals, the right eye was infected with P. lilacinus but not treated with voriconazole (infection control eye). By day 5, the infection controls had lesions of > 2.4 mm in diameter, with conjunctivitis and severe hypopyon, and were sacrificed. In the other 10 rabbits (voriconazole treatment), the right eyes were infected with P. lilacinus and treated with voriconazole beginning on day 3 after infection. Voriconazole therapy caused lesions to decrease during 8 days of therapy, after which rabbits were sacrificed (11 days postinfection). Hyphal masses were present in the control infected eyes and absent in treated infected eyes. Voriconazole was detected in all tissues of treated eyes. Topical voriconazole is effective treatment for P. lilacinus experimental keratitis, and it penetrates more deeply than the corneal tissue. C1 Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis,MC 7881, San Antonio, TX 78229 USA. Natl Univ Singapore, Singapore Eye Res Inst, Singapore 117548, Singapore. Ft Sam Houston, Brooke Army Med Ctr, San Antonio, TX USA. RP Najvar, LK (reprint author), Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis,MC 7881, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM Najvar@uthscsa.edu NR 21 TC 33 Z9 37 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2006 VL 50 IS 1 BP 262 EP 268 DI 10.1128/AAC.50.1.262-268.2006 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 007RT UT WOS:000234988000035 PM 16377696 ER PT J AU Krakauer, T Buckley, M AF Krakauer, T Buckley, M TI Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID T-CELL ACTIVATION; BACTERIAL SUPERANTIGENS; LETHAL SHOCK; HUMAN-DISEASE; LIPOPOLYSACCHARIDE; MACROPHAGES; INHIBITION; ENDOTOXIN; RELEASE AB The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock. C1 USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM teresa.krakauer@det.amedd.army.mil NR 29 TC 24 Z9 24 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2006 VL 50 IS 1 BP 391 EP 395 DI 10.1128/AAC.50.1.391-395.2006 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 007RT UT WOS:000234988000060 PM 16377721 ER PT S AU Urciuoli, DP Tipton, CW AF Urciuoli, DP Tipton, CW GP IEEE TI Development of a 90 kW bi-directional DC-DC converter for power dense applications SO APEC 2006: TWENTY-FIRST ANNUAL IEEE APPLIED POWER ELECTRONICS CONFERENCE AND EXPOSITION, VOLS 1-3 SE Annual IEEE Applied Power Electronics Conference and Exposition (APEC) LA English DT Proceedings Paper CT 21st Annual IEEE Applied Power Electronics Conference (APEC 2006) CY MAR 19-23, 2006 CL Dallas, TX SP IEEE, PELS, IEEE Ind Applicat Soc, Power Sources Manufacturers Assoc AB This paper presents the relevancy, design, and test results of a 90 kW continuous duty, three-phase, bi-directional, DC-DC converter for hybrid electric vehicles. Nominal low-side and high-side voltages of 320 V and 600 V, respectively, were used. Continuous boost-mode operation at 90 kW, and continuous buck-mode operation at 45 kW were demonstrated using 80 degrees C (inlet temperature) Castrol 399 oil coolant. The volumetric power density of the three-phase test-bed was 2.7 kW/l in boost-mode at a coolant temperature of 80 degrees C. Based on two-phase tests, the power density at a coolant temperature of 25 degrees C is projected to be 4.1 kW/l. To increase power level and power density, custom IGBT modules have been built and tested. A design layout for a packaged four-phase converter, using the custom IGBTs, including sensors and control hardware, indicates that a volumetric power density of above 4 kW/l is feasible at an 80 degrees C coolant temperature. C1 US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 5 TC 5 Z9 6 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1048-2334 BN 0-7803-9547-6 J9 APPL POWER ELECT CO PY 2006 BP 1375 EP 1378 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BEB94 UT WOS:000236635700211 ER PT J AU O'Connell, KP Bucher, JR Anderson, PE Cao, CJ Khan, AS Gostomski, MV Valdes, JJ AF O'Connell, KP Bucher, JR Anderson, PE Cao, CJ Khan, AS Gostomski, MV Valdes, JJ TI Real-time fluorogenic reverse transcription-PCR assays for detection of bacteriophage MS2 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID ESCHERICHIA-COLI; WATER-TREATMENT; WASTE-WATER; FELINE CALICIVIRUS; EXAMINATION GLOVES; VIRAL PENETRATION; COLIPHAGE MS2; DISINFECTION; INACTIVATION; VIRUS AB Bacteriophage MS2 is used in place of pathogenic viruses in a wide variety of studies that range from testing of compounds for disinfecting surfaces to studying environmental transport and fate of pathogenic viruses in groundwater. MS2 is also used as a pathogen simulant in the research, development, and testing (including open air tests) of methods, systems, and devices for the detection of pathogens in both the battlefield and homeland defense settings. PCR is often used as either an integral part of such detection systems or as a reference method to assess the sensitivity and specificity of microbial detection. To facilitate the detection of MS2 by PCR, we describe here a set of real-time fluorogenic reverse transcription-PCR assays. The sensitivity of the assays (performed with primer pairs and corresponding dye-labeled probes) ranged from 0.4 to 40 fg of MS2 genomic RNA (200 to 20,000 genome equivalents). We also demonstrate the usefulness of the primer pairs in assays without dye-labeled probe that included the DNA-binding dye SYBR green. None of the assays gave false-positive results when tested against 400 pg of several non-MS2 nucleic acid targets. C1 USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, AMSRD,ECB,RT,BM, Aberdeen Proving Ground, MD 21010 USA. RP O'Connell, KP (reprint author), USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, AMSRD,ECB,RT,BM, 5183 Blackhawk Rd,APG, Aberdeen Proving Ground, MD 21010 USA. EM kevin.oconnell1@us.army.mil NR 43 TC 70 Z9 72 U1 0 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JAN PY 2006 VL 72 IS 1 BP 478 EP 483 DI 10.1128/AEM.72.1.478-483.2006 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 003DW UT WOS:000234662800062 PM 16391081 ER PT S AU Kosheleva, O Cabrera, S Usevitch, B Vidal, E AF Kosheleva, Olga Cabrera, Sergio Usevitch, Brian Vidal, Edward, Jr. BE Dongarra, J Madsen, K Wasniewski, J TI Compressing 3D measurement data under interval uncertainty SO APPLIED PARALLEL COMPUTING: STATE OF THE ART IN SCIENTIFIC COMPUTING SE Lecture Notes in Computer Science LA English DT Article; Proceedings Paper CT 7th International Workshop on State of the Art in Scientific Computing CY JUN 20-23, 2004 CL Lyngby, DENMARK SP Tech Univ Denmark, Dept Informat & Math Modelling, High Performance Comp, Numerical Algorithms Grp Ltd, Comsol A/S Denmark, Sun Microsyst Denmark, UNI C Danish Comp Ctr Denmark, Microsoft Denmark, IBM, Denmark AB The existing image and data compression techniques try to minimize the mean square deviation between the original data f(x, y ,z) and the compressed- decompressed data (f) over tilde (x, y, z). In many practical situations, reconstruction that only guaranteed mean square error over the data set is unacceptable. For example, if we use the meteorological data to plan a best trajectory for a plane, then what we really want to know are the meteorological parameters such as wind, temperature, and pressure along the trajectory. If along this line, the values are not reconstructed accurately enough, the plane may crash - and the fact that on average, we get a good reconstruction, does not help. In general, what we need is a compression that guarantees that for each difference If (x, y, z) - f(x, y, z) I is bounded by a given value Delta - i.e.. that the actual value f (x, y, z) belongs to the interval [(f) over tilde (x, y, z) - Delta, (f) over tilde (x, y, z) + Delta]. In this paper, we describe new efficient techniques for data compression under such interval uncertainty. C1 Univ Texas, Dept Elect & Comp Engn, El Paso, TX 79968 USA. USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Kosheleva, O (reprint author), Univ Texas, Dept Elect & Comp Engn, El Paso, TX 79968 USA. EM olgak@utep.edu; evidal@arl.army.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 3-540-29067-2 J9 LECT NOTES COMPUT SC PY 2006 VL 3732 BP 142 EP 150 PG 9 WC Computer Science, Theory & Methods SC Computer Science GA BEE79 UT WOS:000237003200016 ER PT S AU Evangelista, PF Embrechts, MJ Szymanski, BK AF Evangelista, Paul F. Embrechts, Mark J. Szymanski, Boleslaw K. BE Abraham, A DeBaets, B Koppen, M Nickolay, B TI Taming the curse of dimensionality in kernels and novelty detection SO APPLIED SOFT COMPUTING TECHNOLOGIES: THE CHALLENGE OF COMPLEXITY SE ADVANCES IN SOFT COMPUTING LA English DT Proceedings Paper CT 9th Online Conference on Soft Computing in Industrial Applications CY SEP 20-OCT 08, 2004 CL ELECTR NETWORK SP World Federat Soft Comp, Elsevier, Springer, IEEE Syst, Man & Cybernet Soc, NAFIPS, European Soc Fuzzy Log & Technol, Int Fuzzy Syst Assoc ID SUPPORT AB The curse of dimensionality is a well known but not entirely well-understood phenomena. Too much data, in terms of the number of input variables, is not always a good thing. This is especially true when the problem involves unsupervised learning or supervised learning with unbalanced data (many negative observations but minimal positive observations). This paper addresses two issues involving high dimensional data: The first issue explores the behavior of kernels in high dimensional data. It is shown that variance, especially when contributed by meaningless noisy variables, confounds learning methods. The second part of this paper illustrates methods to overcome dimensionality problems with unsupervised learning utilizing subspace models. The modeling approach involves novelty detection with the one-class SVM. C1 [Evangelista, Paul F.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Embrechts, Mark J.] Rensselaer Polytech Inst, Dept Decis Sci & Engn Syst, Troy, NY 12181 USA. [Szymanski, Boleslaw K.] Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY USA. RP Evangelista, PF (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RI Szymanski, Boleslaw/A-9121-2009 OI Szymanski, Boleslaw/0000-0002-0307-6743 NR 28 TC 10 Z9 10 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1615-3871 BN 3-540-31649-3 J9 ADV SOFT COMP PY 2006 VL 34 BP 425 EP 438 DI 10.1007/3-540-31662-0_33 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications SC Computer Science GA BEN47 UT WOS:000238287700033 ER PT J AU Underwood, D Schwenk, D Briggs, S Bush, J AF Underwood, D Schwenk, D Briggs, S Bush, J TI Open DDC systems - Obstacles and how to avoid them SO ASHRAE JOURNAL LA English DT Article C1 USA, Construct Engn Res Lab, Corps Engineers, Erdc, Champaign, IL 61824 USA. RP Underwood, D (reprint author), USA, Construct Engn Res Lab, Corps Engineers, Erdc, Champaign, IL 61824 USA. NR 5 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEATING REFRIGERATING AIR-CONDITIONING ENG, INC, PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2491 J9 ASHRAE J JI ASHRAE J. PD JAN PY 2006 VL 48 IS 1 BP 18 EP + PG 4 WC Thermodynamics; Construction & Building Technology; Engineering, Mechanical SC Thermodynamics; Construction & Building Technology; Engineering GA 001ER UT WOS:000234516900013 ER PT B AU Sohn, CW Underwood, DM Lin, MCJ AF Sohn, Chang W. Underwood, David M. Lin, Mike C. J. GP ASHRAE TI An ice-ball storage cooling system for a laboratory complex SO ASHRAE Transactions 2006, Vol 112, Pt 1 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT Winter Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers (ASHRAE) CY 2006 CL Chicago, IL AB An ice-ball storage cooling system with a 30,000-gal (113.55-m(3)) storage tank containing 125, 000 dimpled plastic balls has been in successful operation to cool the main complex of the US Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL) in Champaign, Illinois, since October 1996 The unit cools the ERDC-CERL main complex from 10:00 a.m. to 6:00 p.m. (adjustable) during the summer excluding weekends. The nominal design storage capacity of the system is 1700 ton-h (5,974 kWh). The system uses two chillers, which were installed in the spring of 1993. The ice storage cooling system was installed in October 1996 Depending on the ice inventory, one or two 170-ton (597.4-kW) R-22 screw chillers make ice every night. This study found that turning off the chillers reduces about 200 KW of on-peak electrical demand, which resulted in about 15% to 20% electric cost savings for the four summer months. In March 2003, the ice storage tank was opened to study the ice balls for the long-term impact during the past six years of operation. This paper documents the cost benefit, discusses lessons learned from the operation and maintenance of the system, and makes recommendations for future applications. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61824 USA. RP Sohn, CW (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61824 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA J9 ASHRAE TRAN PY 2006 VL 112 BP 676 EP 682 PN 1 PG 7 WC Construction & Building Technology SC Construction & Building Technology GA BEM68 UT WOS:000238183500064 ER PT B AU Berglund, LG Cadarette, BS Kolka, MA Levine, L AF Berglund, Larry G. Cadarette, Bruce S. Kolka, Margaret A. Levine, Leslie GP ASHRAE TI Human responses to internittent work while wearing encapsulating chemical-biological protective clothing with personal HVAC SO ASHRAE Transactions 2006, Vol 112, Pt 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers CY 2006 CL Quebec City, CANADA SP Amer Soc Heating Refrigerating & Air Conditioning Engineers AB Human responses and safe work time limits for persons wearing the US Army's Self-Contained Toxic Environment Protective Ouot (STEPO) with personal CO2 scrubber 02 supply, and upper body cooling system were determined from human tests and human simulation modeling. STEPO is the Army's highest-level protective system. A rational thermal physiological model was assembled to simulate the responses and extend the human test results to other conditions. Comparisons between human and simulated responses include core and skin temperature, heart rate, thermal sensation, and water loss. Safe work time limits were until core temperature and heart rate exceeded 38.3 degrees C (101 degrees F) and 150 bpm. C1 USA, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Berglund, LG (reprint author), USA, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. NR 7 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA J9 ASHRAE TRAN PY 2006 VL 112 BP 231 EP 239 PN 2 PG 9 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BFD56 UT WOS:000241189400021 ER PT B AU Lathrop, SD Gates, CL Massie, DD Hill, JMD AF Lathrop, Scott D. Gates, Christopher L. Massie, Darrell D. Hill, John M. D. GP ASHRAE TI Risk assessment of a power plant: Evaluating the security of a supervisory control and data acquisition system SO ASHRAE Transactions 2006, Vol 112, Pt 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers CY 2006 CL Quebec City, CANADA SP Amer Soc Heating Refrigerating & Air Conditioning Engineers AB With the increased potential of a bona fide cyber terrorist attack and the possibility of a future "war in the wires," we must continue to sterilize the networks connected to critical infrastructures. This paper provides a risk assessment of an existing operational computer network used to control a boiler system generating power and heat for an installation. The methodology used in evaluating the security of the system is described along with specific recommendations for minimizing the risk associated with connecting the network to the Internet for the purposes of remote data collection and administration. Our assessment and proposed recommendations may be applied to any critical infrastructure with a requirement for remote administration and/or data collection. C1 US Mil Acad, Informat Technol & Operat Ctr, West Point, NY 10996 USA. RP Lathrop, SD (reprint author), US Mil Acad, Informat Technol & Operat Ctr, West Point, NY 10996 USA. NR 7 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA J9 ASHRAE TRAN PY 2006 VL 112 BP 671 EP 679 PN 2 PG 9 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BFD56 UT WOS:000241189400061 ER PT S AU Tunick, A AF Tunick, Arnold BE Hammel, SM Kohnle, A TI Modeling microphysical influences on optical turbulence SO ATMOSPHERIC OPTICAL MODELING, MEASUREMENT, AND SIMULATION II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Atmospheric Optical Modeling, Measurement and Simulation II CY AUG 15-16, 2006 CL San Diego, CA SP SPIE DE refractive index structure constant; computer model; buildings; forests; free-space laser communications ID LASER-BEAM; SURFACE LAYER; FOREST; ATMOSPHERE; FLUCTUATIONS; SIMULATION; INDEX; WIND; FLOW AB Optical turbulence is important because it can significantly degrade the performance of electro-optical and infrared sensors, such as free-space laser communications and infrared imaging systems. Changes in the refractive index of air along the transmission path of an optical system in free space can influence traveling light waves temporally and spatially causing blurring, scintillation, and bean wander. If left uncompensated, these effects could cause fades and surges in transmitted signals and result in high bit errors in communicated data. An earlier paper discussed the growing need for increasingly accurate and reliable numerical models to predict optical turbulence conditions, especially in complex (non-uniform) signal propagation environments. Hence, we present a finite difference computer model to predict the microphysical (microclimate) influences on optical turbulence (C-n(2)) around the ARL A_LOT Facility and its surroundings, e.g., forests and multiple buildings. Our multi-dimensional prototypical model begins to address optical turbulence conditions along more complex optical lines-of-site and account for inhomogeneities in C-n(2) brought about by horizontal changes in landscape, wind flow, temperature, and humidity. We anticipate that this kind of computational research will be an important vehicle for investigating C-n(2) and related laser-optic propagation effects in complex areas. C1 USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Tunick, A (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM atunick@arl.army.mil NR 35 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6382-5 J9 PROC SPIE PY 2006 VL 6303 AR 630305 DI 10.1117/12.677683 PG 12 WC Instruments & Instrumentation; Meteorology & Atmospheric Sciences; Optics SC Instruments & Instrumentation; Meteorology & Atmospheric Sciences; Optics GA BFI02 UT WOS:000241946200005 ER PT J AU Acker-Mills, BE Houtsma, AJM Ahroon, WA AF Acker-Mills, BE Houtsma, AJM Ahroon, WA TI Speech intelligibility in noise using throat and acoustic microphones SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE modified rhyme test; diagnostic rhyme test; helicopters; crew communication AB Introduction: Helicopter cockpits are very noisy and this noise must be reduced for effective communication. The standard U.S. Army aviation helmet is equipped with a noise-canceling acoustic microphone, but some ambient noise still is transmitted. Throat microphones are not sensitive to air molecule vibrations and thus, transmittal of ambient noise is reduced. It is possible that throat microphones could enhance speech communication in helicopters, but speech intelligibility with the devices must first be assessed. In the current study, speech intelligibility of signals generated by an acoustic microphone, a throat microphone, and by the combined output of the two microphones was assessed using the Modified Rhyme Test (MRT). Methods: Stimulus words were recorded in a reverberant chamber with ambient broadband noise intensity at 90 and 106 dBA. Listeners completed the MRT task in the same settings, thus simulating the typical environment of a rotary-wing aircraft. Results: Results show that speech intelligibility is significantly worse for the throat microphone (average percent correct = 55.97) than for the acoustic microphone (average percent correct = 69.70), particularly for the higher noise level. In addition, no benefit is gained by simultaneously using both microphones. A follow-up experiment evaluated different consonants using the Diagnostic Rhyme Test and replicated the MRT results. Discussion: The current results show that intelligibility using throat microphones is poorer than with the use of boom microphones in noisy and in quiet environments. Therefore, throat microphones are not recommended for use in any situation where fast and accurate speech intelligibility is essential. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Acker-Mills, BE (reprint author), USA, Aeromed Res Lab, 6901 Andrews Ave,POB 620577, Ft Rucker, AL 36362 USA. EM barbara.acker@us.army.mil NR 7 TC 3 Z9 3 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JAN PY 2006 VL 77 IS 1 BP 26 EP 31 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 001IA UT WOS:000234525600006 PM 16422450 ER PT J AU Paragas, J Endy, TP AF Paragas, Jason Endy, Timothy P. BE Fleming, DO Hunt, DL TI Viral Agents of Human Disease: Biosafety Concerns SO BIOLOGICAL SAFETY: PRINCIPLES AND PRACTICES, 4TH EDITION LA English DT Article; Book Chapter ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; CONGO HEMORRHAGIC-FEVER; HEALTH-CARE WORKERS; BRITISH CLINICAL LABORATORIES; SIMIAN IMMUNODEFICIENCY VIRUS; HANTAVIRUS PULMONARY SYNDROME; PRIMARY-SCHOOL CHILDREN; HEPATITIS-B-VIRUS; WILD HOUSE MICE; HERPESVIRUS-SIMIAE C1 [Paragas, Jason] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Endy, Timothy P.] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. RP Paragas, J (reprint author), USA, Div Virol, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 198 TC 2 Z9 2 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-339-0 PY 2006 BP 179 EP 207 PG 29 WC Medical Laboratory Technology; Microbiology SC Medical Laboratory Technology; Microbiology GA BOY56 UT WOS:000278066800010 ER PT J AU Patel, OV Lintault, L Zakrzewska, E Maple, R Baer, L Ronca, A Wade, C Plaut, K AF Patel, Osman V. Lintault, Laura Zakrzewska, Elzbieta Maple, Rhonda Baer, Lisa Ronca, April Wade, Charles Plaut, Karen TI Hypergravity induced suppression of lactation in periparturient rats: Differential dynamics of prolactin receptor isoform expression following prolactin and bromocryptine supplementation in rats. SO BIOLOGY OF REPRODUCTION LA English DT Meeting Abstract CT 39th Annual Meeting of the Society-for-the-Study-of-Reproduction CY JUL 29-AUG 01, 2006 CL Univ Nebraska Med Ctr, Omaha, NE SP Soc Study Reprod HO Univ Nebraska Med Ctr C1 Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA. Univ Vermont, Dept Anim Sci, Burlington, VT 05405 USA. Univ Vermont, Coll Med, Burlington, VT 05405 USA. NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC STUDY REPRODUCTION PI MADISON PA 1603 MONROE ST, MADISON, WI 53711-2021 USA SN 0006-3363 J9 BIOL REPROD JI Biol. Reprod. PY 2006 SI SI BP 117 EP 117 PG 1 WC Reproductive Biology SC Reproductive Biology GA 063ZW UT WOS:000239059500254 ER PT J AU Smith, PW Anderson, AO Christopher, GW Cieslak, TJ Devreede, GJ Fosdick, GA Greiner, CB Hauser, JM Hinrichs, SH Huebner, KD Iwen, PC Jourdan, DR Kortepeter, MG Landon, VP Lenaghan, PA Leopold, RE Marklund, LA Martin, JW Medcalf, SJ Mussack, RJ Neal, RH Ribner, BS Richmond, JY Rogge, C Roselle, GA Rupp, ME Sambol, AR Schaefer, JE Sibley, J Streifel, AJ Von Essen, SG Warfield, KL AF Smith, Philip W. Anderson, Arthur O. Christopher, George W. Cieslak, Theodore J. Devreede, G. J. Fosdick, Glen A. Greiner, Carl B. Hauser, John M. Hinrichs, Steven H. Huebner, Kermit D. Iwen, Peter C. Jourdan, Dawn R. Kortepeter, Mark G. Landon, V. Paul Lenaghan, Patricia A. Leopold, Robert E. Marklund, Leroy A. Martin, James W. Medcalf, Sharon J. Mussack, Robert J. Neal, Randall H. Ribner, Bruce S. Richmond, Jonathan Y. Rogge, Chuck Roselle, Gary A. Rupp, Mark E. Sambol, Anthony R. Schaefer, Joann E. Sibley, John Streifel, Andrew J. Von Essen, Susanna G. Warfield, Kelly L. TI Designing a biocontainment unit to care for patients with serious communicable diseases: A consensus statement SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID ACUTE RESPIRATORY SYNDROME; PUBLIC-HEALTH MANAGEMENT; LABORATORY EXPOSURES; BIOLOGICAL WEAPONS; HEMORRHAGIC-FEVER; AGENTS; BIOTERRORISM; PREPAREDNESS; INFECTION; SYSTEMS AB In spite of great advances in medicine, serious communicable diseases are a significant threat. Hospitals must be prepared to deal with patients who are infected with pathogens introduced by a bioterrorist act (e.g., smallpox), by a global emerging infectious disease (e.g., avian influenza, viral hemorrhagic fevers), or by a laboratory accident. One approach to hazardous infectious diseases in the hospital setting is a biocontainment patient care unit (BPCU). This article represents the consensus recommendations from a conference of civilian and military professionals involved in the various aspects of BPCUs. The role of these units in overall U.S. preparedness efforts is discussed. Technical issues, including medical care issues (e.g., diagnostic services, unit access); infection control issues (e.g., disinfection, personal protective equipment); facility design, structure, and construction features; and psychosocial and ethical issues, are summarized and addressed in detail in an appendix. The consensus recommendations are presented to standardize the planning, design, construction, and operation of BPCUs as one element of the U.S. preparedness effort. C1 Univ Nebraska, Med Ctr 985400, Biocontainment Unit, Omaha, NE 68198 USA. USAMRIID, Ft Detrick, MD USA. USAF, MC Wilford Hall Med Ctr, Lackland AFB, TX USA. Brooke Army Med Ctr, Dept Pediat, Ft Sam Houston, TX 78234 USA. Univ Nebraska, Peter Kiewit Inst, Omaha, NE 68182 USA. Nebraska Med Ctr, Omaha, NE USA. Univ Nebraska, Med Ctr, Omaha, NE 68182 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Nebraska Hlth & Human Serv, Lincoln, NE USA. USA, Trauma Training Ctr, Miami, FL USA. Ctr Biopreparedness Educ, Omaha, NE USA. Leo A Daly Architects, Omaha, NE USA. USAF, Offutt AFB, NE USA. Emory Univ Hosp, Atlanta, GA 30322 USA. Jonathan Richmond & Associates, Southport, NC USA. VA Med Ctr, Cincinnati, OH USA. Nebraska Hlth & Human Serv, Lincoln, NE USA. Kiewit Bldg Grp Inc, Omaha, NE USA. Univ Minnesota, Dept Environm Hlth & Safety, Minneapolis, MN USA. RP Smith, PW (reprint author), Univ Nebraska, Med Ctr 985400, Biocontainment Unit, Omaha, NE 68198 USA. EM pwsmith@unmc.edu NR 39 TC 40 Z9 42 U1 2 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PY 2006 VL 4 IS 4 BP 351 EP 365 DI 10.1089/bsp.2006.4.351 PG 15 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 120OX UT WOS:000243095500010 PM 17238819 ER PT J AU Park, JT Bradbury, L Kragl, FJ Lukens, DC Valdes, JJ AF Park, JT Bradbury, L Kragl, FJ Lukens, DC Valdes, JJ TI Rapid optimization of antibotulinum toxin antibody fragment production by an integral approach utilizing RG-SELDI mass spectrometry and statistical design SO BIOTECHNOLOGY PROGRESS LA English DT Article ID IDENTIFICATION AB A process for the rapid development and optimization of the fermentation process for an antibotulinum neurotoxin antibody fragment (bt-Fab) production expressed in Escherichia coli was achieved via a high-throughput process proteomics and statistical experimental design. This process, using retentate chromatography-surface enhanced laser des orption/ionization mass spectrometry (RC-SELDI MS), was employed for identifying and quantifying bt-Fab antibody in complex biological samples for the optimization of microbial fermentation conditions. Five variables (type of culture media, glycerol concentration, post-induction temperature, IPTG concentration, and incubation time after induction) were statistically combined using an experimental 2(5-1) fractional factorial design and tested for their effects on maximal bt-Fab antibody production. When the effects of individual variables and their interactions were assessed, type of media and post-induction temperature showed statistically significant increase in yield of the fermentation process for the maximal bt-Fab antibody production. This study establishes an integral approach as a valuable tool for the rapid development of manufacturing processes for producing various biological materials. To verify the RC-SELDI MS method, a Fab-specific immuno-affinity HPLC assay developed here was also employed for the quantification of the bt-Fab antibody in crude lysate samples obtained during the fermentation optimization process. Similar results were obtained. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Ciphergen Biosyst Inc, Fremont, CA 94555 USA. Geocenters Inc, Aberdeen Proving Ground, MD 21010 USA. RP Park, JT (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM jun.park@us.arruy.mil NR 24 TC 8 Z9 8 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD JAN-FEB PY 2006 VL 22 IS 1 BP 233 EP 240 DI 10.1021/bp050158t PG 8 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 011CB UT WOS:000235244100032 PM 16454515 ER PT J AU Perkins, EJ Bao, WJ Guan, X Ang, CY Wolfinger, RD Chu, TM Meyer, SA Inouye, LS AF Perkins, Edward J. Bao, Wenjun Guan, Xin Ang, Choo-Yaw Wolfinger, Russell D. Chu, Tzu-Ming Meyer, Sharon A. Inouye, Laura S. TI Comparison of transcriptional responses in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT Symposium of Computations in Bioinformatics and Bioscience in Conjunction with the International Multi-Symposium on Computer and Computational Sciences CY JUN 20-24, 2006 CL Hangzhou, PEOPLES R CHINA ID GENE-EXPRESSION; SYSTEMS; SLICES; LINES; RDX AB Background: Cell culture systems are useful in studying toxicological effects of chemicals such as Hexahydro-1,3,5-trinitro-1,3,5-triazine ( RDX), however little is known as to how accurately isolated cells reflect responses of intact organs. In this work, we compare transcriptional responses in livers of Sprague-Dawley rats and primary hepatocyte cells after exposure to RDX to determine how faithfully the in vitro model system reflects in vivo responses. Results: Expression patterns were found to be markedly different between liver tissue and primary cell cultures before exposure to RDX. Liver gene expression was enriched in processes important in toxicology such as metabolism of amino acids, lipids, aromatic compounds, and drugs when compared to cells. Transcriptional responses in cells exposed to 7.5, 15, or 30 mg/L RDX for 24 and 48 hours were different from those of livers isolated from rats 24 hours after exposure to 12, 24, or 48 mg/Kg RDX. Most of the differentially expressed genes identified across conditions and treatments could be attributed to differences between cells and tissue. Some similarity was observed in RDX effects on gene expression between tissue and cells, but also significant differences that appear to reflect the state of the cell or tissue examined. Conclusion: Liver tissue and primary cells express different suites of genes that suggest they have fundamental differences in their cell physiology. Expression effects related to RDX exposure in cells reflected a fraction of liver responses indicating that care must be taken in extrapolating from primary cells to whole animal organ toxicity effects. C1 USA, Engn Res & Dev Ctr, Vicksburg, MS USA. SAS Inst Inc, Cary, NC USA. SpecPro, Vicksburg, MS USA. Univ Louisiana, Monroe, LA USA. RP Perkins, EJ (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM edward.j.perkins@us.army.mil; wenjun.bao@sas.com; xin.guan@us.army.mil; choo.y.ang@us.army.mil; russ.wolfinger@sas.com; tzu-ming.chu@sas.com; meyer@ulm.edu; laura.s.inouye@us.army.mil NR 18 TC 10 Z9 11 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PY 2006 VL 7 SU 4 AR S22 DI 10.1186/1471-2105-7-S4-S22 PG 11 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 144IL UT WOS:000244789600022 PM 17217515 ER PT S AU Baker, EL Pfau, D Pincay, JM Vuong, T Ng, KW AF Baker, E. L. Pfau, D. Pincay, J. M. Vuong, T. Ng, K. W. BE Brebbia, CA Katsikadelis, JT TI High rate continuum modeling mesh reduction methodologies and advanced applications SO Boundary Elements and Other Mesh Reduction Methods XXVIII SE WIT TRANSACTIONS ON MODELLING AND SIMULATION LA English DT Proceedings Paper CT 28th World Conference on Boundary Elements and Other Mesh Reduction Methods CY MAY, 2006 CL Skiathos, GREECE SP Wessex Inst Technol, Int Journal Engn Anal Boundary Elements DE mesh reduction methodologies; high rate continuum modeling; impact physics; high explosives AB A variety of mesh reduction methodologies (MRM) have been developed for use in high rate continuum modeling. An adaptive mesh refinement (AMR) technique has been implemented for use in the CTH high rate Eulerian finite difference model. This new implementation allows increased rectilinear mesh refinement in localized areas of interest. We have applied this AMR to successfully resolve dominating physical phenomena involved in concrete wall impact modeling, as well as physical phenomena observed at the material interface of explosively welded metals. In addition, a variety of MRM relaxation algorithms have been developed for high rate continuum Arbitrary Lagrangian-Eulerian (ALE) modeling. These relaxation algorithms are now routinely used to provide the high resolution simulation of explosively produced metal jetting using the CALE computer program. Finally, a multi-mesh MRM technique has been implemented in the ALE-3D computer model. This MRM technique has been used to provide the modeling of fragment impact for the development of safer munitions. These new MRM techniques are now allowing the high rate continuum modeling of physical phenomena that was not previously simulated. C1 USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. RP Baker, EL (reprint author), USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU WIT PRESS/COMPUTATIONAL MECHANICS PUBLICATIONS PI SOUTHAMPTON PA ASHURST LODGE, ASHURST, SOUTHAMPTON SO40 7AA, ENGLAND SN 1746-4064 BN 1-84564-164-7 J9 WIT TRANS MODEL SIM PY 2006 VL 42 BP 111 EP 118 DI 10.2495/BE06012 PG 8 WC Engineering, Electrical & Electronic; Engineering, Mechanical; Mathematics, Applied; Mechanics SC Engineering; Mathematics; Mechanics GA BEJ59 UT WOS:000237450600012 ER PT B AU Doherty, KJ Tice, JR Szewczyk, ST Gilde, GA AF Doherty, Kevin J. Tice, Jason R. Szewczyk, Steven T. Gilde, Gary A. BE Stephens, JJ Weil, KS TI Titanium Brazing for Structures and Survivability SO BRAZING AND SOLDERING, PROCEEDINGS LA English DT Proceedings Paper CT 3rd International Brazing and Soldering Conference CY APR 24-26, 2006 CL San Antonio, TX SP ASM Int, AWS AB Titanium is a candidate as a structural material for all new tactical and armored ground vehicles, because of its high strength-to-weight ratio, excellent corrosion resistance, and inherent ballistic resistance. However, titanium as a structural material is much less mature than both steel and aluminum alloys, especially in the area of joining. While welding is the typical joining method for titanium, vacuum brazing is an option in areas that are difficult to access for welding as well as areas near other nonmetallic materials, such as ceramics. This work focuses on vacuum brazing of titanium (both Ti-6Al-4V and commercially pure titanium) and the effect of processing changes (alloy, temperature, pressure), including post-braze hot isostatic pressing, on mechanical properties and microstructure. This study will examine the joining of both plate materials as well as lightweight, periodic pyramidal core structures. Shear and tensile testing is performed to determine the strength/ductility relationship to the various processing routes. Microscopy (optical and SEM) is employed to quantify the degree of bonding and to examine the microstructural changes, both within the base materials and at the bond line, associated with the process variations. C1 [Doherty, Kevin J.; Tice, Jason R.; Szewczyk, Steven T.; Gilde, Gary A.] USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Doherty, KJ (reprint author), USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. EM kdoherty@arl.army.mil OI doherty, kevin/0000-0002-5806-5283 NR 5 TC 1 Z9 1 U1 0 U2 1 PU ASM INTERNATIONAL PI MATERIALS PARK PA 9503 KINSMAN RD, MATERIALS PARK, OH 44073 USA BN 978-0-87170-838-0 PY 2006 BP 268 EP 273 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA BPY36 UT WOS:000280337000044 ER PT J AU Ellsworth, DL Kostyniak, PJ Gillard, D Love, B Ellsworth, RE Deyarmin, B Hooke, JA Shriver, CD AF Ellsworth, D. L. Kostyniak, P. J. Gillard, D. Love, B. Ellsworth, R. E. Deyarmin, B. Hooke, J. A. Shriver, C. D. TI Abundance and distribution of persistent environmental pollutants in breast tissue following mastectomy. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. SUNY Buffalo, Buffalo, NY USA. Invitrogen Corp, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S244 EP S245 PG 2 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101279 ER PT J AU Ellsworth, DL Seeley, EH Ellsworth, RE Deyarmin, B Sanders, ME Cornett, DS Hooke, JA Caprioli, RM Shriver, CD AF Ellsworth, D. L. Seeley, E. H. Ellsworth, R. E. Deyarmin, B. Sanders, M. E. Cornett, D. S. Hooke, J. A. Caprioli, R. M. Shriver, C. D. TI Direct tissue characterization of protein expression in metastatic breast cancer. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Vanderbilt Univ, Nashville, TN USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S7 EP S8 PG 2 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100023 ER PT J AU Ellsworth, RE Love, B Kane, J Ellsworth, DL Hooke, JA Shriver, CD AF Ellsworth, R. E. Love, B. Kane, J. Ellsworth, D. L. Hooke, J. A. Shriver, C. D. TI Levels and patterns of genomic instability are correlated with histological grading of invasive breast tumors. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Invitrogen Informat, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S295 EP S295 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101432 ER PT J AU Ellsworth, RE Weyandt, J Patney, HL Shriver, CD AF Ellsworth, R. E. Weyandt, J. Patney, H. L. Shriver, C. D. TI Role of the Q356R BRCA1 variant in sporadic breast cancer. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S250 EP S250 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101297 ER PT J AU Ellsworth, RE Hooke, JA Kane, J Baran, P Kovatich, A Shriver, CD AF Ellsworth, R. E. Hooke, J. A. Kane, J. Baran, P. Kovatich, A. Shriver, C. D. TI Discordance of pathological characteristics between primary breast tumors and metastatic lymph nodes. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global, Windber, PA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S173 EP S173 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101066 ER PT J AU Field, LA Ellsworth, RE Hooke, JA Bronfman, L Gutchell, V Love, B Weyandt, J Shriver, CD AF Field, L. A. Ellsworth, R. E. Hooke, J. A. Bronfman, L. Gutchell, V Love, B. Weyandt, J. Shriver, C. D. TI Differences in biology and outcome of breast cancer in African American versus Caucasian women are not due to socioeconomic factors alone. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Invitrogen Informat, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S142 EP S142 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100412 ER PT J AU Hu, H Zhang, Y Kvecher, L Sun, W Hooke, J Mural, R Liebman, MN Shriver, CD AF Hu, H. Zhang, Y. Kvecher, L. Sun, W. Hooke, J. Mural, R. Liebman, M. N. Shriver, C. D. TI Different characteristics of invasive breast cancers between Caucasian and African American women. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S142 EP S142 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100411 ER PT J AU Jordan, RM Brzeski, H Hu, H Shriver, CD Mural, R Liebman, MN Yang, YC AF Jordan, R. M. Brzeski, H. Hu, H. Shriver, C. D. Mural, R. Liebman, M. N. Yang, Y-C TI Utilizing genes identified from peripheral blood leukocyte microarray data to identify clinical subsets of breast histopathologies. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S39 EP S39 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100111 ER PT J AU Khoo, S Storrer, CE Harris, KA Jama, YH Dehqanzoda, ZA Mittendorf, EA Murray, JL Shriver, CD von Hofe, E Ponniah, S Peoples, GE AF Khoo, S. Storrer, C. E. Harris, K. A. Jama, Y. H. Dehqanzoda, Z. A. Mittendorf, E. A. Murray, J. L. Shriver, C. D. von Hofe, E. Ponniah, S. Peoples, G. E. TI Results of a phase I clinical trial of an Ii-Key/HER2/neu MHC class II peptide-based vaccine in breast cancer patients. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Natl Naval Med Ctr, Bethesda, MD USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Antigen Express Inc, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S78 EP S78 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100225 ER PT J AU Nissan, A Allweis, TM Sklair-Levi, M Sela, T Prus, D Klein, M Peretz, T Hamburger, T Stojadinovic, A AF Nissan, A. Allweis, T. M. Sklair-Levi, M. Sela, T. Prus, D. Klein, M. Peretz, T. Hamburger, T. Stojadinovic, A. TI Wire versus radioisotope localization of occult breast lesions: a prospective randomized trial. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Hadassah Hebrew Univ Med Ctr, Jerusalem, Israel. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S118 EP S118 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100341 ER PT J AU Papa, NN Robert, W AF Papa, N. N. Robert, W. TI Breast cancer in Pacific Island women: a comparative ethnic study of clinicopathological factors and outcomes. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S276 EP S277 PG 2 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101375 ER PT J AU Peoples, GE Khoo, S Dehqanzada, ZA Mittendorf, EA Hueman, MT Gurney, JM Woll, MM Ryan, GB Storrer, CE Harris, KA Jama, YH Smith, AM Shriver, CD Ioannides, CG Ponniah, S AF Peoples, G. E. Khoo, S. Dehqanzada, Z. A. Mittendorf, E. A. Hueman, M. T. Gurney, J. M. Woll, M. M. Ryan, G. B. Storrer, C. E. Harris, K. A. Jama, Y. H. Smith, A. M. Shriver, C. D. Ioannides, C. G. Ponniah, S. TI Combined clinical trial results of a HER2/neu (E75) vaccine for prevention of recurrence in high-risk breast cancer patients. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Immunol Res Ctr, Bethesda, MD USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S6 EP S6 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047100018 ER PT J AU Seebach, JF Field, LA Love, B Hooke, JA Shriver, CD AF Seebach, J. F. Field, L. A. Love, B. Hooke, J. A. Shriver, C. D. TI Identification of gene expression differences in primary breast and metastatic lymph node tumors. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 29th Annual San Antonio Breast Cancer Symposium CY DEC 14-17, 2006 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med, Canc Therapy Res Ctr, Univ Texas, Hlth Sci Ctr C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Windber Res Inst, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 2006 VL 100 SU 1 BP S206 EP S206 PG 1 WC Oncology SC Oncology GA 105QJ UT WOS:000242047101165 ER PT J AU Abosi, AO Mbukwa, E T Majinda, RR Raseroka, BH Yenesew, A Midiwo, JO Akala, H Liyala, P Waters, NC AF Abosi, A. O. Mbukwa, E. T Majinda, R. R. Raseroka, B. H. Yenesew, A. Midiwo, J. O. Akala, H. Liyala, P. Waters, N. C. TI Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity SO BRITISH JOURNAL OF BIOMEDICAL SCIENCE LA English DT Article DE biological factors; plant extracts; plants, medicinal; plasmodium berghei; plasmodium falciparum; vangueria infausta ID PLASMODIUM-FALCIPARUM MALARIA; QUANTITATIVE ASSESSMENT; CHLOROQUINE RESISTANCE; TANZANIA; PLANTS; MEDICINE; REMEDIES; CULTURE; DRUG AB Vangueria infausta burch subsp. infausta (Rubiaceae) produces fruits eaten by humans and animals. The leaf, fruit, stem bark and root bark are used as a remedy for many ailments and the roots are used to treat malaria. In this study, concentrations of fractions of the V infausta root bark extract that produce 50% inhibition (IC50) are determined using the ability of the extract to inhibit the uptake of [G(3)H]-hypoxanthine by P. falciparum cultured in vitro. The root bark extract showed antimalarial activity against Plasmodium berghei in mice. It gave a parasite suppression of 73.5% in early infection and a repository effect of 88.7%. One fraction obtained from a chloroform extract gave an IC50 value of 3.8 +/- 1.5 mu g/mL and 4.5 +/- 2.3 mu g/mL against D-6 and W-2 strains of P. falciparum, respectively, and another from the butanol extract gave an IC50 value of 3.9 +/- 0.3 mu g/mL against the D6 strain. Chloroquine had an IC50 value of 0.016 mu g/mL and 0.029 mu g/mL against D-6 andW(2) strains, respectively. The plant showed the presence of flavonoids, coumarins, tannins, terpenoids, anthraquinones and saponins. C1 Univ Botswana, Dept Biol Sci, Gaborone, Botswana. Univ Botswana, Dept Chem, Gaborone, Botswana. Univ Nairobi, Dept Chem, Nairobi, Kenya. USA, Resp Med Unit Kenya, APO, AE 09831 USA. RP Abosi, AO (reprint author), Univ Botswana, Dept Biol Sci, POB 70050,UB Post Off, Gaborone, Botswana. EM tonia603@hotmail.com NR 29 TC 4 Z9 4 U1 0 U2 2 PU STEP PUBLISHING LTD PI TUNBRIDGE WELLS PA SUBSCRIPTION DEPT, NORTH FARM RD, TUNBRIDGE WELLS TN2 3DR, KENT, ENGLAND SN 0967-4845 J9 BRIT J BIOMED SCI JI Br. J. Biomed. Sci. PY 2006 VL 63 IS 3 BP 129 EP 133 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 095BO UT WOS:000241283400005 PM 17058713 ER PT J AU Salas, E Rosen, MA Burke, CS Goodwin, GF Fiore, SM AF Salas, Eduardo Rosen, Michael A. Burke, C. Shawn Goodwin, Gerald F. Fiore, Stephen M. BE Ericsson, KA Charness, N Feltovich, PJ Hoffman, RR TI The Making of a Dream Team: When Expert Teams Do Best SO CAMBRIDGE HANDBOOK OF EXPERTISE AND EXPERT PERFORMANCE LA English DT Article; Book Chapter ID MANAGEMENT TEAMS; MENTAL MODELS; WORK GROUPS; PERFORMANCE; LEADERSHIP; KNOWLEDGE; FRAMEWORK; EFFICACY C1 [Salas, Eduardo; Rosen, Michael A.; Burke, C. Shawn] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. [Salas, Eduardo; Rosen, Michael A.; Burke, C. Shawn; Fiore, Stephen M.] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA. [Goodwin, Gerald F.] USA, Res Inst, Washington, DC USA. RP Salas, E (reprint author), Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. NR 87 TC 34 Z9 34 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-52184-097-2 PY 2006 BP 439 EP 453 D2 10.2277/ 0521600812 PG 15 WC Psychology, Multidisciplinary SC Psychology GA BXQ34 UT WOS:000296708200025 ER PT J AU Straight, AM Oakley, K Moores, R Bauer, AJ Patel, A Tuttle, RM Jimeno, J Francis, GL AF Straight, AM Oakley, K Moores, R Bauer, AJ Patel, A Tuttle, RM Jimeno, J Francis, GL TI Aplidin reduces growth of anaplastic thyroid cancer xenografts and the expression of several angiogenic genes SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article DE thyroid cancer; aplidin; angiogenesis ID MARINE-DERIVED DEPSIPEPTIDE; CARCINOMA CELL-LINES; IN-VITRO; DEHYDRODIDEMNIN-B; CHROMOGRANIN-A; ANTINEOPLASTIC ACTIVITY; LIQUID-CHROMATOGRAPHY; CLINICAL DEVELOPMENT; ANTICANCER AGENT; ANTITUMOR AGENT AB Background. Anaplastic thyroid cancer (ATC) is one of the most aggressive and highly lethal human cancers. Median survival after diagnosis is 4-6 months despite available radiotherapy and chemotherapy. Additional treatments are needed for ATC. Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulus, which is expressed by ATC. Previously, anti-VEGF antibody was used to block VEGF-dependent angiogenesis in ATC xenografts. This treatment induced partial (56%) but not complete tumor regression. Aplidin (APLD) is a marine derived antitumor agent currently in phase II clinical studies. Multiple activities of this compound have been described which likely contribute to its antiproliferative effect. Notably, APLD has been shown to have antiangiogenic properties which include: inhibition of VEGF secretion, reduction in the synthesis of the VEGF receptor (FLT-1), and blockade of matrix metalloproteinase production by endothelial cells. We hypothesized that Aplidin, with its broad spectrum of action and antiangiogenic properties, would be a potentially effective drug against ATC. Methods: Thirty BALB/c nu/nu mice were injected with ATC cells (ARO-81, 1X10(6)) and allowed to implant for 3 weeks. Animals were randomized to receive daily intraperitoneal injections of vehicle, low dose (0.5 mg/kg/day), or high dose (1.0 mg/kg/day) APLD. After 3 days, the animals were killed and the tumors were removed, weighed, and divided for RNA and protein analyses. Results: APLD significantly reduced ATC xenograft growth (low dose, 20% reduction, P=0.01; high dose, 40% reduction, P<0.001). This was associated with increased levels of apoptosis related proteins polyadenosylribose polymerase 85 (PARP-85, 75% increase, P=0.024) and caspase 8 (greater than fivefold increase, P=0.03). APLD treatment was further associated with lost or reduced expression of several genes that support angiogenesis to include: VEGF, hypoxia inducible factor 1(HIF-1), transforming growth factor-beta (TGF beta), TGF beta receptor 2 (TGF beta R2), melanoma growth stimulating factor 1 (GRO1), cadherin, and vasostatin. Conclusions: This data supports the hypothesis that APLD may be an effective adjunctive therapy against ATC. The demonstrated molecular impact against angiogenic related genes specifically supports future strategies combining APLD with VEGF interacting agents. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Endocrinol Sect, New York, NY 10021 USA. PharmaMar SAU RD Colmenar Viejo, Madrid, Spain. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM gfrancis@usuhs.mil NR 50 TC 42 Z9 45 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD JAN PY 2006 VL 57 IS 1 BP 7 EP 14 DI 10.1007/s00280-005-0014-7 PG 8 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 990XG UT WOS:000233776100002 PM 16001179 ER PT J AU Shah, M Zhu, KM Potter, J AF Shah, Mona Zhu, Kangmin Potter, John TI Hispanic acculturation and utilization of colorectal cancer screening in the United States SO CANCER DETECTION AND PREVENTION LA English DT Article DE fecal occult blood test (FOBT); endoscopy sigmoidoscopy; colonoscopy; proctoscopy; non-Hispanic White; language barriers; cultural; barriers; sociodemographic variables; education; family incomes; Hispanics; colorectal cancer; screening; acculturation ID PREVENTIVE SERVICES; HEALTH; CARE; POPULATION; WOMEN AB Background: Despite the evidence on the effectiveness of colorectal cancer (CRC) screening procedures, its use remains low, especially among Hispanics. Social-cultural factors may play a role in the underutilization of cancer screening. This study aimed to examine whether low acculturation was a risk factor for the underutilization of colorectal cancer screening in the Hispanic population. Methods: The subjects were adults aged 50-80 years who identified themselves as Hispanic and never were diagnosed with colorectal cancer. Colorectal cancer screening utilization was assessed based on the use of at-home Fecal Occult Blood Test (FOBT) and the use of endoscopies (sigmoidoscopy, colonoscopy, or proctoscopy). Respondents who underwent a test for diagnostic purposes were excluded from the study. Results: Our data showed that colorectal screening was underused in Hispanics compared to non-Hispanic Whites. There was a trend that acculturation level was inversely correlated with having an endoscopy in the past 5 years. This trend was also seen with having a FOBT in the past year or an endoscopy in the past 5 years. However, the association disappeared after adjusting for factors pertaining to utilizing other health care services. Additionally, after stratifying by gender, the association between the two variables was diluted. Conclusions: The findings show that low acculturation was associated with the underutilization of endoscopic colorectal cancer screening. This association may be related to lower utilization of health care services and/or language barriers that may contribute to the lower utilization. (c) 2006 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved. C1 Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Shah, M (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite E-111,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM mona.shah@na.amedd.army.mil NR 18 TC 41 Z9 41 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0361-090X J9 CANCER DETECT PREV JI Cancer Detect. Prev. PY 2006 VL 30 IS 3 BP 306 EP 312 DI 10.1016/j.cdp.2006.04.003 PG 7 WC Oncology SC Oncology GA 082NJ UT WOS:000240393300013 PM 16872756 ER PT J AU Mulligan, CR Meram, AD Proctor, CD Wu, HY Zhu, KM Marrogi, AJ AF Mulligan, CR Meram, AD Proctor, CD Wu, HY Zhu, KM Marrogi, AJ TI Unlimited access to care: Effect on racial disparity and prognostic factors in lung cancer SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID GROWTH-FACTOR; SURVIVAL; STAGE; CARCINOMA; SMOKING; PREDICTOR; DIAGNOSIS; WOMEN; POOR; AGE AB Study Objective: Evaluate the prognostic factors influencing lung cancer survival under a universal health care system and determine if access to care eliminates clinical outcome disparity. Design: Retrospective case series review. Background: Lung cancer survival is worse in men and in African Americans, thought to be related to poor general health in men and limited access to heath care in African Americans. The Military Health Care System, with unlimited access to care, provides an excellent setting for evaluating gender and racial disparities in lung cancer survival. Methods: Lung cancers diagnosed at Walter Reed Army Medical Center, from 1990 to 2000, were evaluated by chart review for age, gender, race, smoking history, cancer history, histology, stage, and completeness of resection. Results: Seven hundred thirteen Caucasians and 173 African Americans, 2:1 male predominance, had a 22% 5-year survival. Cox model analysis showed that male gender [hazard ratio (HR, 1.31; 95% confidence interval (95% CI), 1.02-1.68], advanced-stage disease (stage III: HR, 2.58; 95% CI, 1.57-4.26/stage IV: HR, 4.20; 95% CI, 2.51-7.41), and incomplete resection (HR, 4.06; 95% Cl, 2.75-5.99) were predictors of poor outcome; whereas bronchoalveolar carcinoma features (HR, 0.35; 95% CI, 0.23-0.52) and smoking cessation >7 years (HR, 0.70; 95% Cl, 0.49-0.99) were predictors of favorable outcome. No ethnic differences in survival were observed. Conclusions: No racial disparities in survival when access to medical care is universal. Male gender, incomplete resection, and advanced stage are significant predictors of poor outcome in lung cancer. C1 Walter Reed Army Med Ctr, Dept Pathol, Div Anat Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Div Cardiothorac Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Lab Biomarkers & Carcinogenesis, CBCP IRC Dept Surg 2, Bethesda, MD 20814 USA. RP Marrogi, AJ (reprint author), Walter Reed Army Med Ctr, Dept Pathol, Div Anat Pathol, Room 4710A,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Aizen.Marrogi@na.amedd.army.mil NR 36 TC 59 Z9 59 U1 1 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2006 VL 15 IS 1 BP 25 EP 31 DI 10.1158/1055-9965.EPI-05-0537 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 005ZZ UT WOS:000234866200007 PM 16434582 ER PT S AU Swim, C Vanderbeek, R Emge, D Wong, A AF Swim, Cynthia Vanderbeek, Richard Emge, Darren Wong, Anna BE Gardner, PJ Fountain, AW TI Overview of chem-bio sensing - art. no. 621802 SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE AB The US Army Edgewood Chemical Biological Center is the leader in development of military systems for chemical and biological defense, in collaboration with all Services, other Government laboratories, academia, and industry. Chemical and biological optical sensing principles, unique capabilities, state-of-the-art sensors, and emerging technologies will be discussed. Exciting new results will be presented on standoff biodiscrimination using infrared (IR) depolarization lidar and long-wave IR (LWIR) lidar. C1 USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA. RP Swim, C (reprint author), USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP 21802 EP 21802 AR 621802 DI 10.1117/12.669835 PG 8 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700002 ER PT S AU Radicic, WN Ni, EV Tombrello, C Fountain, AW AF Radicic, William N. Ni, Eric V. Tombrello, Christin Fountain, Augustus W., III BE Gardner, PJ Fountain, AW TI Characterizing the spectral reproducibility of quartz-bound Au nanoparticle substrates for surface-enhanced Raman spectroscopy - art. no. 621803 SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE SERS; substrate reproducibility; Raman; nanotechnology; Au nanoparticles ID SCATTERING; FILMS; AG AB Visible extinction and Surface Enhanced Raman Scattering (SERS) spectra using quartz-bound Au nanoparticle substrates are used to identify substrate production-related sources of spectral variability. Hydrosol Au nanoparticle size distributions are known to affect SERS enhancement, but the effect of spatial orientation and nanoparticle physiosorption during substrate preparation on spectral reproducibility and performance are not well understood. Experiments varying quartz slide orientation and Au nanoparticle delivery method show significant concentration-gradient and physiosorption-related aggregation effects in the substrate extinction spectra and SERS spectra of R6G applied to spatially mapped substrate regions. Additionally, applying multiple Au hydrosol treatments to functionalized quartz substrates reveals interesting relationships between Au nanoparticle thickness and substrate extinction and SERS spectra. Of the many factors affecting substrate spectral reproducibility, minimizing concentration gradients and optimizing the rate of Au nanoparticle-quartz physiosorption allow improvements in SERS active substrate spectral reproducibility. C1 US Mil Acad, Photon Res Ctr, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Radicic, WN (reprint author), US Mil Acad, Photon Res Ctr, Dept Chem & Life Sci, West Point, NY 10996 USA. NR 11 TC 1 Z9 1 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP 21803 EP 21803 AR 621803 DI 10.1117/12.664078 PG 9 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700003 ER PT S AU Heaps, DA Pellegrino, PM AF Heaps, David A. Pellegrino, Paul M. BE Gardner, PJ Fountain, AW TI Examination of quantum cascade laser source for a MEMS-scale photoacoustic chemical sensor - art. no. 621805 SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE photoacoustics; microelectromechanical systems; piezoelectrics; chemical sensor ID MINIATURIZATION; INTEGRATION; CELL AB Photoacoustic spectroscopy is a useful monitoring technique that is well suited for trace gas detection. The technique also possesses favorable detection characteristics when the system dimensions are scaled to a micro-system design. The objective of present work is to incorporate two strengths of the Army Research Laboratory (ARL), Quantum Cascade Laser (QCL) source development and chemical and biological sensing into a monolithic micro-electromechanical systems (MEMS) photoacoutic trace gas sensor. Past examination of a 1/4 scale photoacoustic (PA) macro-cell has indicated a pathway to incorporate a photoacoustic resonance structure in a micro-mechanical platform. Initial studies involve the incorporation of a QCL source operating @ similar to 3.45 mu m into the PA macro-cell system as a means to discern proper operational characteristics in relation to the photoacoustic cell design. Results will be presented describing beam conditioning, modulation control and wavelength selection associated with the QCL source. Some preliminary information regarding MEMS-scale designs based off of hybrid concept, involving commercially available microphone and fully fabricated MEMS photoacoustic resonator will be described. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Heaps, DA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 8 TC 7 Z9 7 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP 21805 EP 21805 AR 621805 DI 10.1117/12.670040 PG 9 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700005 ER PT S AU Christesen, SD Lochner, JM Hyre, AM Emge, DK AF Christesen, Steven D. Lochner, Joseph M. Hyre, Aaron M. Emge, Darren K. BE Gardner, PJ Fountain, AW TI UV Raman spectra and cross sections of chemical agents - art. no. 621809 SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE UV Raman; chemical agents; Raman cross sections AB UV Raman spectroscopy is being applied to the detection of natural and man-made surfaces contaminated with chemical agents. In support of these efforts, we have measured the UV Raman signatures of chemical agents and their simulants. In addition, we have measured both the UV Raman and UV absorption cross sections of these compounds for determining their relative limits of detection. The UV Raman measurements were made using a doubled Argon ion laser operating at 248 nm. Spectra were collected on an echelle spectrograph equipped with a CCD array detector. Based on the data collected, we also discuss the suitability of currently accepted agent simulants for testing UV Raman detection instruments. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Christesen, SD (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP 21809 EP 21809 AR 621809 DI 10.1117/12.669841 PG 8 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700009 ER PT S AU Liu, JY McKenna, TM Gribok, A Beidleman, BA Tharion, WT Reifman, J AF Liu, Jingyu McKenna, Thomas M. Gribok, Andrei Beidleman, Beth A. Tharion, William T. Reifman, Jaques BE Gardner, PJ Fountain, AW TI Estimation of confidence levels for physiology variables measured by a vital signs detection system - art. no. 621818 SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE heart rate; respiratory rate; fuzzy logic; confidence levels AB Quantifying the accuracy of physiological data measured by a Vital Signs Detection System (VSDS) plays a key role in making trustworthy decisions about the physiological status of a soldier. We developed an algorithm to report VSDS-measured heart and respiratory rates and their associated confidence levels. Heart and respiratory rates were measured about every 2 seconds for about 4 hours, while subjects engaged in low (e.g., sitting), medium (e.g., sit-ups), and high intensity (e.g., running) activities. The mean heart and median respiratory rates are calculated every 15 seconds by an in-house developed algorithm, and associated confidence levels for each variable are estimated simultaneously using a fuzzy-logic-based algorithm. Inputs into the algorithm are features that represent two types of information; the quality of each variable, and the relationship between the variables. Faulty data points are separated from good measures by setting a threshold. When data with pre-classified faults are tested with the confidence level threshold set at 0.5, the sensitivity and specificity of the algorithm for heart rate are 91 % and 97%, respectively. For respiratory rate, because of the intrinsically noisy property of the data, the sensitivity and specificity are 87% and 93%, respectively. These preliminary results demonstrate that the fuzzy logic algorithm can accurately qualify heart and respiratory rates measured by a VSDS. C1 USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Liu, JY (reprint author), USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP 21818 EP 21818 AR 621818 DI 10.1117/12.665965 PG 8 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700034 ER PT S AU Cabalo, J De Lucia, M Narayanan, F Poldmae, A Sickenberger, D AF Cabalo, Jerry De Lucia, Marla Narayanan, Fiona Poldmae, Aime Sickenberger, David BE Gardner, PJ Fountain, AW TI Deep-UV solid state light sources in the tactical biological sensor - art. no. 62180D SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE ID FLUORESCENCE SPECTROSCOPY; PRINCIPAL-COMPONENTS; IDENTIFICATION; BIOAEROSOLS; SPECTRA AB A number of strategies to meet the need for a small and inexpensive biosensor that mitigates military and civilian vulnerabilities to biological weapons are currently being pursued. Among them is UV induced biological fluorescence. UV induced biofluorescence is a potentially successful strategy because it involves no chemical consumables and it is an "on-line" detection method where particles can be interrogated without impaction onto a substrate or into a liquid. Indeed, there are already existing fluorescence based sensors already in place, yet these are limited by the cost and power consumption of the laser based UV excitation sources. Fortunately, inexpensive and low power solid state UV sources arising from the Defense Advanced Research Projects Agency's (DARPA) Semiconductor UV Optical Sources (SUVOS) project have become commercially available in wavelengths capable of exciting aromatic amino acids (e.g. tryptophan) and metabolic products (e.g. NADH). The TAC-Bio Sensor is capable of exploiting either source wavelength and will ultimately include both source wavelengths within a single sensor. Initial work with the deep UV sources involves the correct optical filtering for the devices. The primary emission from both the 280 nm and 340 nm devices occurs at the design wavelength and is about 20 run FWHM, however, there is a tail extending to the longer wavelengths that interferes with the fluorescence signal. A system of optical filters that sufficiently removes the long wavelength component from the UV source is designed and tested for the deep UV sources. Ongoing work with the sensor has confirmed that sensitivity to small biological particles is enhanced with the deeper wavelengths. When the 340 nm sources are placed in the TAC-Bio, it is capable of detecting 4 micron diameter Bacillus globigii (BG, Dugway, washed 4X) spore agglomerates. The deep UV sources show an improvement in signal to noise of 2, permitting the detection of 3 micron diameter BG agglomerates. C1 USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. RP Cabalo, J (reprint author), USA, ECBC, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 8 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP D2180 EP D2180 AR 62180D DI 10.1117/12.665769 PG 9 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700012 ER PT S AU Guicheteau, J Christesen, SD AF Guicheteau, Jason Christesen, Steven D. BE Gardner, PJ Fountain, AW TI Principal component analysis of bacteria using surface-enhanced Raman spectroscopy - art. no. 62180G SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE SERS; bacteria; PCA ID DIPICOLINIC ACID; BACILLUS SPORES; SILVER; DISCRIMINATION; CELLS; SERS AB Surface-enhanced Raman scattering (SERS) provides rapid fingerprinting of biomaterial in a non-destructive manner. The problem of tissue fluorescence, which can overwhelm a normal Raman signal from biological samples, is largely overcome by treatment of biomaterials with colloidal silver. This work presents a study into the applicability of qualitative SER spectroscopy with principal component analysis (PCA) for the discrimination of four biological threat simulants; Bacillus globigii, Pantoea agglomerans, Brucella noetomae, and Yersinia rohdei. We also demonstrate differentiation of gram-negative and gram-positive species and as well as spores and vegetative cells of Bacillus globigii. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Guicheteau, J (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 36 TC 4 Z9 4 U1 0 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP G2180 EP G2180 AR 62180G DI 10.1117/12.664502 PG 8 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700015 ER PT S AU Guicheteau, J Argue, L Hyre, A Jacobson, M Christesen, SD AF Guicheteau, Jason Argue, Leanne Hyre, Aaron Jacobson, Michele Christesen, Steven D. BE Gardner, PJ Fountain, AW TI Raman and surface-enhanced Raman spectroscopy of amino acids and nucleotide bases for target bacterial vibrational mode identification - art. no. 62180O SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE Raman; SERS; amino acids; nucleotides; bacteria ID INFRARED-SPECTRA; SCATTERING SERS; SILVER; DISCRIMINATION; ADSORPTION; CHEMISTRY; CELLS; DNA AB Raman and surface-enhanced Raman spectroscopy (SERS) studies of bacteria have reported a wide range of vibrational mode assignments associated with biological material. We present Raman and SER spectra of the amino acids phenylalanine, tyrosine, tryptophan, glutamine, cysteine, alanine, proline, methionine, asparagine, threonine, valine, glycine, serine, leucine, isoleucine, aspartic acid and glutamic acid and the nucleic acid bases adenosine, guanosine, thymidine, and uridine to better characterize biological vibrational mode assignments for bacterial target identification. We also report spectra of the bacteria Bacillus globigii, Pantoea agglomerans, and Yersinia rhodei along with band assignments determined from the reference spectra obtained. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Guicheteau, J (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21010 USA. NR 28 TC 10 Z9 10 U1 4 U2 11 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP O2180 EP O2180 AR 62180O DI 10.1117/12.670294 PG 11 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700021 ER PT S AU Hohil, ME Desail, S Morcos, A AF Hohil, Myron E. Desai, Sachi Morcos, Amir BE Gardner, PJ Fountain, AW TI Implementation of algorithms to discriminate chemical/biological airbursts from high explosive airbursts utilizing acoustic signatures - art. no. 62180X SO Chemical and Biological Sensing VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensing VII CY APR 19-21, 2006 CL Kissimmee, FL SP SPIE DE acoustic sensors; CBRN; chemical; biological; CB; high explosive; HE; neural networks; wavelets; multiresolutional analysis; PAWSS AB The Army is currently developing acoustic sensor systems that will provide extended range surveillance, detection, and identification for force protection and tactical security. A network of such sensors remotely deployed in conjunction with a central processing node (or gateway) will provide early warning and assessment of enemy threats, near real-time situational awareness to commanders, and may reduce potential hazards to the soldier. In contrast, the current detection of chemical/biological (CB) agents expelled into a battlefield environment is limited to the response of chemical sensors that must be located within close proximity to the CB agent. Since chemical sensors detect hazardous agents through contact, the sensor range to an airburst is the key-limiting factor in identifying a potential CB weapon attack. The associated sensor reporting latencies must be minimized to give sufficient preparation time to field commanders, who must assess if an attack is about to occur, has occurred, or if occurred, the type of agent that soldiers might be exposed to. The long-range propagation of acoustic blast waves from heavy artillery blasts, which are typical in a battlefield environment, introduces a feature for using acoustics and other sensor suite technologies for the early detection and identification of CB threats. Employing disparate sensor technologies implies that warning of a potential CB attack can be provided to the solider more rapidly and from a safer distance when compared to current conventional methods. Distinct characteristics arise within the different airburst signatures because High Explosive (HE) warheads emphasize concussive and shrapnel effects, while chemical/biological warheads are designed to disperse their contents over immense areas, therefore utilizing a slower burning, less intensive explosion to mix and distribute their contents. Highly reliable discrimination (100%) has been demonstrated at the Portable Area Warning Surveillance System (PAWSS) Limited Objective Experiment (LOE) conducted by Joint Project Manager for Nuclear Biological Contamination Avoidance (JPM NBC CA) and a matrixed team from Edgewood Chemical and Biological Center (ECBC) at ranges exceeding 3km. The details of the field-test experiment and real-time implementation/integration of the standalone acoustic sensor system are discussed herein. C1 USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. RP Hohil, ME (reprint author), USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. NR 7 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6274-8 J9 P SOC PHOTO-OPT INS PY 2006 VL 6218 BP X2180 EP X2180 AR 62180X DI 10.1117/12.667876 PG 12 WC Instruments & Instrumentation SC Instruments & Instrumentation GA BES56 UT WOS:000239300700027 ER PT S AU Jacobson, ML Corbman, JD Rowlen, KL AF Jacobson, Michele L. Corbman, Jordan D. Rowlen, Kathy L. BE Christesen, SD Sedlacek, AJ Gillespie, JB Ewing, KJ TI The photodynamics of Ag thin metal film surface enhanced Raman spectroscopy substrates SO Chemical and Biological Sensors for Industrial and Environmental Monitoring II SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensors for Industrial and Environmental Monitoring II CY OCT 03-04, 2006 CL Boston, MA SP SPIE DE SERS; photodynamics; thin metal films; metal clusters ID SINGLE-MOLECULE; SCATTERING; ELECTRODES; PYRIDINE; SERS; OXYGEN; ELIMINATION; JUNCTIONS AB Surface enhanced Raman spectroscopy (SERS) has been widely demonstrated to be capable of single molecule detection. In addition to enhancement of Raman scattering, the substrates used for SERS also display other unique optical properties such as photoluminescence and blinking. In this work, the photoactivation of Ag thin metal films as it relates to the mechanism of SERS enhancement and the production of Ag cluster SERS active sites was explored. Specifically, the photodynamics of SERS-active thin Ag films were qualitatively studied using a combination of optical imaging and high and low resolution spectroscopy. A key hypothesis tested in this work addressed the role of oxygen in thin metal film photodynamics. Based on spectroscopic and kinetic differences observed from thin Ag films under both ambient and nitrogen atmospheres, a simple photochemical mechanism for blinking in optical phenomena was developed and tested. The proposed mechanism relies on the photoreduction of silver oxide to produce an active species, which was postulated to be silver clusters. C1 USA, Edgewood Chem Biol Ctr, Natl Res Council, Boulder, CO 80309 USA. RP Jacobson, ML (reprint author), USA, Edgewood Chem Biol Ctr, Natl Res Council, Boulder, CO 80309 USA. NR 28 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-6476-7 J9 P SOC PHOTO-OPT INS PY 2006 VL 6378 BP U50 EP U57 DI 10.1117/12.685136 PG 8 WC Instruments & Instrumentation; Optics SC Instruments & Instrumentation; Optics GA BFR00 UT WOS:000243904500006 ER PT S AU Smith, C Tatineni, B Anderson, J Tepper, G AF Smith, Clint Tatineni, Balaji Anderson, John Tepper, Gary BE Christesen, SD Sedlacek, AJ Gillespie, JB Ewing, KJ TI Optical bar code recognition of methyl salicylate (MES) for environmental monitoring using fluorescence resonance energy transfer (FRET) on thin films SO Chemical and Biological Sensors for Industrial and Environmental Monitoring II SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Chemical and Biological Sensors for Industrial and Environmental Monitoring II CY OCT 03-04, 2006 CL Boston, MA SP SPIE DE fluorescence resonance energy transfer; methyl salicylate; thin films; InGaP quantum dots ID STEADY-STATE AB Fluorescence resonance energy transfer (FRET) is a process in which energy is transferred nonradiatively from one fluorophore (the donor) in an excited electron state to another, the chromophore (the acceptor). FRET is distinctive in its ability to reveal the presence of specific recognition of select targets such as the nerve agent stimulant Methyl Salicylate (MES) upon spectroscopic excitation. We introduce a surface imprinted and non-imprinted thin film that underwent AC-Electrospray ionization for donor-acceptor pair(s) bound to InGaP quantum dots and mesoporous silicate nanoparticles. The donor-acceptor pair used in this investigation included MES (donor) and 6-(fluorescein-5-(and-6)carboxamido) hexanoic acid, succinimidyl ester bound to InGaP quantum dots (acceptor). MES was then investigated as a donor to various acceptor fluorophore: InGaP: mesoporous silicate nanoparticle layers. C1 USA, Engineer Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Smith, C (reprint author), USA, Engineer Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. NR 14 TC 1 Z9 1 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-6476-7 J9 P SOC PHOTO-OPT INS PY 2006 VL 6378 BP U231 EP U235 DI 10.1117/12.684416 PG 5 WC Instruments & Instrumentation; Optics SC Instruments & Instrumentation; Optics GA BFR00 UT WOS:000243904500026 ER PT J AU Qasim, M AF Qasim, M TI Chem 3D Ultra SO CHEMICKE LISTY LA English DT Software Review C1 USA, Ctr Environm, Vicksburg, MS 39180 USA. RP Qasim, M (reprint author), USA, Ctr Environm, Vicksburg, MS 39180 USA. EM Qasimm@wes.army.mil NR 0 TC 1 Z9 1 U1 0 U2 1 PU CHEMICKE LISTY PI PRAGUE 6 PA NOVOTNEHO LAVKA 5, PRAGUE 6 116 68, CZECH REPUBLIC SN 0009-2770 J9 CHEM LISTY JI Chem. Listy PY 2006 VL 100 IS 4 BP A16 EP A16 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 036CI UT WOS:000237048100006 ER PT J AU Rocheleau, S Kuperman, RG Martel, M Paquet, L Bardai, G Wong, S Sarrazin, M Dodard, S Gong, P Hawari, J Checkai, RT Sunahara, GI AF Rocheleau, S Kuperman, RG Martel, M Paquet, L Bardai, G Wong, S Sarrazin, M Dodard, S Gong, P Hawari, J Checkai, RT Sunahara, GI TI Phytotoxicity of nitroaromatic energetic compounds freshly amended or weathered and aged in sandy loam soil SO CHEMOSPHERE LA English DT Article DE TNT; TNB; dinitrotoluene; plant toxicity; weathering and aging; hormesis; natural soil ID EARTHWORM EISENIA-ANDREI; 2,4,6-TRINITROTOLUENE TNT; ENCHYTRAEUS-ALBIDUS; CHRONIC TOXICITY; HIGHER-PLANTS; METABOLITES; HORMESIS; OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE; BIOTRANSFORMATION; BIOAVAILABILITY AB The toxicities of 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitrobenzene (TNB), 2,4-dinitrotoluene (2,4-DNT), and 2,6dinitrotoluene (2,6-DNT) to terrestrial plants alfalfa (Medicago saliva L.), Japanese millet (Echinochloa crusgalli L.), and perennial ryegrass (Lolium perenne L.) were determined in Sassafras sandy loam soil using seedling emergence, fresh shoot, and dry mass measurement endpoints. A 13-week weathering and aging of energetic materials in soils, which included wetting and drying cycles, and exposure to Sunlight of individual soil treatments, was incorporated into the study design to better reflect the soil exposure conditions in the field than toxicity determinations in freshly amended soils. Definitive toxicity tests showed that dinitrotoluenes were more phytotoxic for all plant species in freshly amended treatments based on EC20 values for dry shoot ranging from 3 to 24 mg kg(-1) compared with values for TNB or TNT ranging from 43 to 62 mg kg(-1). Weathering and aging of energetic materials (EMs) in soil significantly decreased the toxicity of TNT, TNB or 2,6-DNT to Japanese millet or ryegrass based on seedling emergence, but significantly increased the toxicity of all four EMs to all three plant species based on shoot growth. Exposure of the three plant species to relatively low concentrations of the four compounds initially stimulated plant growth before the onset of inhibition at greater concentrations (hormesis). (c) 2005 Elsevier Ltd. All rights reserved. C1 Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. USA, Edgewood Chem Biol Ctr, AMSRD, ECB,RT,TE, Aberdeen Proving Ground, MD 21010 USA. RP Sunahara, GI (reprint author), Analyt Serv Inc, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM sylvie.rocheleau@cnrc-nrc.gc.ca; geoffrey.sunahara@cnrc-nrc.gc.ca RI Kuperman, Roman/D-4297-2009; OI Kuperman, Roman/0000-0001-5344-1633 NR 45 TC 28 Z9 29 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2006 VL 62 IS 4 BP 545 EP 558 DI 10.1016/j.chemosphere.2005.06.057 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 007GC UT WOS:000234955800006 PM 16112172 ER PT J AU Best, EPH Geter, KN Tatem, HE Lane, BK AF Best, EPH Geter, KN Tatem, HE Lane, BK TI Effects, transfer, and fate of RDX from aged soil in plants and worms SO CHEMOSPHERE LA English DT Article DE explosives; aged soil; biotransfer; Lolium; Medicago; Eisenia ID ARMY AMMUNITION PLANT; TNT; EXPLOSIVES; HMX AB The objectives of this study were to provide data that can be used to predict exposure-based effects of RDX in aged soil on multiple endpoint organisms representing two trophic levels. These data can be used for defining criteria or reference values for environmental management and conducting specific risk assessment. Dose-response experiments formed the basis for the evaluation of toxic effects and transfer of contaminants from soil into two trophic levels. Long-term exposure tests were conducted to evaluate chronic, sublethal, toxicity and transfer of aged soil-based explosives, with RDX as main contaminant. In these tests, plants were exposed for 55 days in the greenhouse, biomass was determined and residues of explosives parent compounds and RDX metabolites were analyzed using HPLC techniques. Worms were exposed for 28 days (Eisenia fetida) and 42 days (Enchytraeus crypticus) in the laboratory, biomass and number were determined, and tissues were analyzed for explosives compounds. The plants tolerated concentrations up to 1540 mg RDX kg(-1) soil-DW. Biomass of Lolium perenne was not significantly related to soil-RDX concentration, while biomass of Medicago sativa significantly increased. No screening benchmark for RDX in soil for plants was calculated, since concentrations up to 1540 mg kg(-1) soil failed to reduce biomass by 20% as required for a LOEC. RDX, RDX-metabolite MNX, and accompanying HMX concentrations in plants were significantly related to concentrations in soil after 55 days of exposure (RDX: R-2 = 0.77-0.89; MNX R-2 = 0.53-0.77; HMX: R-2 = 0.67-0.71). The average bioconcentration factors (BCF) were for RDX 17 in L. perenne and 37 in M. sativa, and for HMX 2 in L. perenne and 44 in M. sativa. The worms also tolerated concentrations up to 1540 mg RDX kg(-1) soil-DW. Biomass of E fetida adults decreased with soil-RDX concentration, and a LOEC of 1253 mg kg(-1) soil-DW was estimated. RDX concentrations in E. fetida were significantly related to concentrations in soil after 28-day exposure (R-2 = 0.88). The average BCF in E. felida for RDX was 1. Because in response to exposure to RDX-contaminated soil the RDX concentrations in plants increased initially and decreased Subsequently, while those in worms increased continuously, RDX in worm tissues may accumulate to higher concentrations than in plant tissues, regardless of the low average BCF for worms. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Analyt Serv Inc, Vicksburg, MS 39180 USA. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM beste@wes.army.mil NR 30 TC 26 Z9 26 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2006 VL 62 IS 4 BP 616 EP 625 DI 10.1016/j.chemosphere.2005.05.039 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA 007GC UT WOS:000234955800014 PM 16045966 ER PT J AU Bidus, MA Risinger, JI Chandramouli, GVR Dainty, LA Litzi, TJ Berchuck, A Barrett, JC Maxwell, GL AF Bidus, MA Risinger, JI Chandramouli, GVR Dainty, LA Litzi, TJ Berchuck, A Barrett, JC Maxwell, GL TI Prediction of lymph node metastasis in patients with endometrioid endometrial cancer using expression microarray SO CLINICAL CANCER RESEARCH LA English DT Article; Proceedings Paper CT 35th Annual Meeting of the Society-of-Gynecologic-Oncologists CY FEB 07-11, 2004 CL San Diego, CA SP Soc Gynecol Oncol ID CYCLIN-DEPENDENT KINASES; CARCINOMA; MUTATION; CA-125; MEDULLOBLASTOMA; OVEREXPRESSION; PROTEINS; ZIC2; P53 AB Purpose: To characterize the gene expression profiles of endometrioid endometrial cancers associated with lymph node metastasis in an effort to identify genes associated with metastatic spread. Experimental Design: Tumors from 41 patients with endometrioid endometrial cancer grossly confined to the uterine cavity were evaluated. Positive lymph nodes were noted in 12 of 41 patients. RNA was analyzed for gene expression using the Affymetrix HG133A and HG133B GeneChip set, representing 45,000 array features covering > 28,000 UniGene clusters. Data analysis was done using multidimensional scaling, binary comparison, and hierarchical clustering. Gene expression for several differentially expressed genes was examined using quantitative PCR. Results: Gene expression data was obtained from 30,964 genes that were detected in at least 5% of the cases. Supervised analysis of node-positive versus node-negative cases indicated that 450 genes were significantly differentially expressed between the two classes at P < 0.005, 81 of which were differentially expressed by at least 2-fold at P < 0.005. Overexpressed genes included two cell cycle checkpoint genes, CDC2 and MAD2L1, which have previously been described in association with lymph node metastasis in other cancer types. The Z/C2 zinc finger gene was overexpressed in endometrial cancers with positive nodes versus those with negative nodes. Conclusion: Gene expression profiling of the primary tumors in patients with endometrioid endometrial cancers seems promising for identifying genes associated with lymph node metastasis. Future studies should address whether the status of nodal metastasis can be determined from the expression profiles of preoperative tissue specimens. C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. US Mil Canc Inst, Washington, DC USA. Natl Canc Inst, Lab Biosyst & Canc, Bethesda, MD USA. Duke Univ, Div Gynecol Oncol, Dept Obstet & Gynecol, Durham, NC USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, 6900 Georgia Ave, Washington, DC 20307 USA. EM george.maxwell@na.amedd.army.mil FU Intramural NIH HHS NR 33 TC 38 Z9 40 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JAN 1 PY 2006 VL 12 IS 1 BP 83 EP 88 DI 10.1158/1078-0432.CCR-05-0835 PG 6 WC Oncology SC Oncology GA 001AG UT WOS:000234503700014 PM 16397028 ER EF