FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bui-Mansfield, LT Kaplan, KJ Hollcraft, C AF Bui-Mansfield, LT Kaplan, KJ Hollcraft, C TI Calcified lymphangioma of the gonadal vein SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 Wake Forest Univ, Sch Med, Dept Radiol, Winston Salem, NC 27157 USA. Keller Army Community Hosp, Dept Radiol, W Point, NY 10996 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Bui-Mansfield, LT (reprint author), Wake Forest Univ, Sch Med, Dept Radiol, Med Ctr Blvd, Winston Salem, NC 27157 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 2002 VL 179 IS 6 BP 1480 EP 1480 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 618FK UT WOS:000179407900018 PM 12438039 ER PT J AU Coleman, RE Maneechai, N Ponlawat, A Kumpitak, C Rachapaew, N Miller, RS Sattabongkot, J AF Coleman, RE Maneechai, N Ponlawat, A Kumpitak, C Rachapaew, N Miller, RS Sattabongkot, J TI Short report: Failure of the OptiMAL (R) rapid malaria test as a tool for the detection of asymptomatic malaria in an area of Thailand endemic for Plasmodium falciparum and P-vivax SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DIAGNOSIS; MICROSCOPY; DIPSTICK AB We evaluated the efficacy of the OptiMAL(R) assay in a cross-sectional malaria survey in western Thailand from April to August 2001. Expert microscopy of Giemsa-stained thick and thin blood films was used as the gold standard. Positive control lines were evident in 99% (1,128 of 1,137) of the assays tested. However, 34% (384 of 1,128) of assays produced an aberrant result (a positive P. falciparum-specific line and a negative panmalarial line). False-positive panmalarial and Plasmodium falciparum-specific lines occurred in 25.9% (270 of 1,042) and 60.3% (628 of 1,042) of microscopy-negative samples, respectively. Due to the preponderance of false-positive test results, it was necessary to develop subjective criteria for test positivity based on line intensity. For determination of assay performance during this study, we therefore considered all test lines that were scored as intermediate or strong as positive and lines that were faint as negative. Using these criteria, we determined that the sensitivity of the OptiMAL(R) assay for P. falciparum was 25% with > 500 parasites/mul and 10.5% with > 100 parasites/mul, while for P. vivax, the sensitivity at the same parasite rates was 100% and 41.7%, respectively. Further studies are required to determine whether the problems we identified are limited to this particular lot of OptiMAL(R) assays. C1 Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Dept Immunol, Bangkok 10400, Thailand. RP Coleman, RE (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. NR 14 TC 25 Z9 26 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2002 VL 67 IS 6 BP 563 EP 565 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 628QJ UT WOS:000180007500002 PM 12518844 ER PT J AU Shell-Gellasch, A AF Shell-Gellasch, A TI Mina Rees and the funding of the mathematical sciences SO AMERICAN MATHEMATICAL MONTHLY LA English DT Article C1 US Mil Acad, Dept Math Sci, W Point, NY 10996 USA. RP Shell-Gellasch, A (reprint author), US Mil Acad, Dept Math Sci, W Point, NY 10996 USA. NR 35 TC 2 Z9 2 U1 0 U2 0 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 USA SN 0002-9890 J9 AM MATH MON JI Am. Math. Mon. PD DEC PY 2002 VL 109 IS 10 BP 873 EP 889 DI 10.2307/3072455 PG 17 WC Mathematics SC Mathematics GA 620PC UT WOS:000179540900001 ER PT J AU Schure, MR Maier, RS Kroll, DM Davis, HT AF Schure, MR Maier, RS Kroll, DM Davis, HT TI Simulation of packed-bed chromatography utilizing high-resolution flow fields: Comparison with models SO ANALYTICAL CHEMISTRY LA English DT Article ID REVERSED-PHASE CHROMATOGRAPHY; PRESSURE-DRIVEN FLOW; LIQUID-CHROMATOGRAPHY; POROUS-MEDIA; NUMERICAL-SIMULATION; FIXED-BEDS; COMPUTER-SIMULATION; MAGNETIC-RESONANCE; LATERAL DIFFUSION; NMR MEASUREMENTS AB A computer simulation of a section of the interior region of a liquid chromatographic column is performed. The detailed fluid flow profile is provided from a microscopic calculation of low Reynolds number flow through a random packed bed of nonporous spherical particles. The fluid mechanical calculations are performed on a parallel processor computer utilizing the lattice Boltzmann technique. Convection, diffusion, and retention in this flow field are calculated using a stochastic-based algorithm. This computational scheme provides for the ability to reproduce the essential dynamics of the chromatographic process from the fundamental considerations of particle geometry, particle size, flow velocity, solute diffusion coefficient, and solute retention parameters when retention is utilized. The simulation data are fit to semiempirical models. The best agreement is found for the "coupling" model of Giddings and the four-parameter Knox model. These models are verified over a wide range of particle sizes and flow velocities at both low and high velocity. The simulations appear to capture the essential dynamics of the chromatographic flow process for non-dimensional flow velocities (Peclet number) less than 500. Since the same packing geometry is utilized for different particle size studies, the interpretation of the parameter estimates from these models can be extended to the physical column model. The simulations reported here agree very well with a number of experiments reported previously. C1 Rohm & Haas Co, Theoret Separat Sci Lab, Spring House, PA 19477 USA. Univ Minnesota, USA, High Performance Comp Res Ctr, Minneapolis, MN 55415 USA. Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA. Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA. RP Schure, MR (reprint author), Rohm & Haas Co, Theoret Separat Sci Lab, 727 Norristown Rd,Box 0904, Spring House, PA 19477 USA. NR 96 TC 40 Z9 41 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD DEC 1 PY 2002 VL 74 IS 23 BP 6006 EP 6016 DI 10.1021/ac0204101 PG 11 WC Chemistry, Analytical SC Chemistry GA 621YC UT WOS:000179617700019 PM 12498196 ER PT J AU Modi, JR Cratty, MS AF Modi, JR Cratty, MS TI Fluvastatin-induced rhabdomyolysis SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE creatine kinase; fluvastatin; renal failure; rhabdomyolysis ID RENAL-TRANSPLANT RECIPIENTS; A-REDUCTASE INHIBITORS; ADVERSE DRUG-REACTIONS; COMBINATION THERAPY; SAFETY EXPERIENCE; CONCOMITANT USE; LOVASTATIN; CYCLOSPORINE; EFFICACY; EXERCISE AB OBJECTIVE: To demonstrate a case of rhabdomyolysis with acute renal failure in a patient receiving fluvastatin and to present evidence that this was an adverse drug reaction to fluvastatin. CASE SUMMARY: A 51-year-old white man with a past medical history significant for hyperlipidemia treated with fluvastatin presented with malaise, myalgias, nausea, and lumbar back pain. The patient had azotemia with elevated creatine kinase (CK), lactate dehydrogenase, and transaminases. He developed hematuria and proteinuria. Laboratory results demonstrated a normal antinuclear antibody, rheumatoid factor, angiotensin-converting enzyme, antineutrophil cytoplasmic antibody, and thyroid-stimulating hormone. Cytomegalovirus and Epstein-Barr virus titers were negative for recent infection. There were no signs of systemic infection; the white blood cell count was normal and blood and urine cultures were negative. Renal ultrasound showed hyperechoic renal cortices with no obstruction. The discontinuation of fluvastatin and hemodialysis led to a rapid decrease in CK and improvement in symptoms. DISCUSSION: Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have the potential to cause rhabdomyolysis. However, fluvastatin is rarely associated with rhabdomyolysis when compared to other statins. Differences in biochemical and pharmacokinetic properties between fluvastatin and other HMG-CoA reductase inhibitors may be important in the development of rhabdomyolysis. CONCLUSIONS: Fluvastatin was the precipitating factor causing rhabdomyolysis in this case report. This patient had no other findings to suggest infection or other disorder inducing rhabdomyolysis. An objective causality assessment revealed that the adverse drug reaction was probable as determined by the Naranjo probability scale. Fluvastatin has the potential to cause serious adverse effects. Therefore, a heightened awareness by the patient and physician for potential signs of myopathy is recommended. C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Penn State Univ, Coll Med, Dept Med & Pediat, Hershey, PA USA. RP Cratty, MS (reprint author), Allegheny Gen Hosp, Dept Med & Pediat, 320 E North Ave, Pittsburgh, PA 15212 USA. NR 34 TC 4 Z9 5 U1 1 U2 2 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD DEC PY 2002 VL 36 IS 12 BP 1870 EP 1874 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 622TV UT WOS:000179663900007 PM 12452746 ER PT J AU Stojadinovic, A Shaha, AR Orlikoff, RF Nissan, A Kornak, MF Singh, B Boyle, JO Shah, JP Brennan, MF Kraus, DH AF Stojadinovic, A Shaha, AR Orlikoff, RF Nissan, A Kornak, MF Singh, B Boyle, JO Shah, JP Brennan, MF Kraus, DH TI Prospective functional voice assessment in patients undergoing thyroid surgery SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT Annual Meeting of the European-Surgical-Association CY APR, 2002 CL LISBON, PORTUGAL SP European Surg Assoc ID SUPERIOR LARYNGEAL NERVE; EXTERNAL BRANCH; INJURY; PARALYSIS AB Objective To analyze voice function before and after thyroidectomy for patients with normal preoperative voice using a standardized multidimensional voice assessment protocol. Summary Background Data The natural history of post-thyroidectomy voice disturbances for patients with preserved laryngeal nerve function has not been systematically studied and characterized with the intent of using the data for postoperative voice rehabilitation. Methods During a prospective single-arm study, patients with normal voice underwent functional voice testing using a standardized voice grading scale and a battery of acoustic, aerodynamic, glottographic, and videostroboscopic tests before, 1 week after, and 3 months after thyroidectomy. Differences in observed sample means were evaluated using analysis of covariance or t test; categorical data was analyzed using the Fisher exact or chi-square test. Results Fifty-four patients were enrolled; 50 and 46 were evaluable at 1 week and 3 months, respectively. No patient developed recurrent laryngeal nerve injury; one had superior laryngeal nerve injury. Fifteen (30%) patients reported early subjective voice change and seven (14%) reported late (3-month) subjective voice change. Forty-two (84%) patients had significant objective change in at least one voice parameter. Six (12%) had significant alterations in more than three voice measures, of which four (67%) were symptomatic, whereas 25% with three or fewer objective changes had symptoms. Patients with persistent voice change at 3 months had an increased likelihood of multiple (more than three) early objective changes (43% vs. 7%). Early maximum phonational frequency range and vocal jitter changes from baseline were significantly associated with voice symptoms at 3 months. Conclusions Early vocal symptoms are common following thyroidectomy and persist in 14% of patients. Multiple (more than three) objective voice changes correlate with early and late postoperative symptoms. Alterations in maximum phonational frequency range and vocal jitter predict late perceived vocal changes. Factors other than laryngeal nerve injury appear to alter post-thyroidectomy voice. The variability of patient symptoms underscores the importance of understanding the physiology of dysphonia. C1 Mem Sloan Kettering Canc Ctr, Head & Neck Serv, Dept Surg, New York, NY 10021 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. CUNY Hunter Coll, Commun Sci Program, New York, NY USA. Walter Reed Army Med Ctr, Biostat Sect, Dept Clin Invest, Washington, DC USA. RP Kraus, DH (reprint author), Mem Sloan Kettering Canc Ctr, Head & Neck Serv, Dept Surg, 1275 York Ave, New York, NY 10021 USA. OI Orlikoff, Robert/0000-0003-0048-6541; Shah, Jatin/0000-0002-6444-6592 NR 21 TC 114 Z9 122 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD DEC PY 2002 VL 236 IS 6 BP 823 EP 832 DI 10.1097/00000658-200212000-00015 PG 10 WC Surgery SC Surgery GA 624BK UT WOS:000179739700026 PM 12454521 ER PT J AU Bao, W Trevino, SF Lynn, JW Pagliuso, PG Sarrao, JL Thompson, JD Fisk, Z AF Bao, W Trevino, SF Lynn, JW Pagliuso, PG Sarrao, JL Thompson, JD Fisk, Z TI Effect of pressure on magnetic structure in heavy-fermion CeRhIn5 SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article; Proceedings Paper CT International Conference on Neutron Scattering CY SEP 09-13, 2001 CL MUNICH, GERMANY ID UNCONVENTIONAL SUPERCONDUCTIVITY; CEIRIN5; CECOIN5 AB The effect of hydrostatic pressure on the incommensurate antiferromagnetic structure of CeRhIn5 is investigated with neutron diffraction using a He pressure cell. At 3.8 kbar, the staggered magnetic moment is 0.37(4) mu(B) per Ce ion at 1.6 K, which is the same as the ambient-pressure value. The Neel temperature T-N = 3.8(l) K is also the same as the ambient-pressure one, although the curve of the order parameter has changed with pressure. The incommensurability delta of the magnetic wave vector q(M) = (1/2, 1/2, delta) has reduced from delta = 0.297 at ambient pressure to delta = 0.294(l) at 3.8 kbar. C1 Los Alamos Natl Lab, Los Alamos, NM 87544 USA. Natl Inst Stand & Technol, Ctr Neutron Res, Gaithersburg, MD 20899 USA. USA, Res Lab, Adelphi, MD 20783 USA. Florida State Univ, Tallahassee, FL 32306 USA. RP Los Alamos Natl Lab, POB 1663, Los Alamos, NM 87544 USA. EM wbao@lanl.gov RI Pagliuso, Pascoal/C-9169-2012; Bao, Wei/E-9988-2011 OI Bao, Wei/0000-0002-2105-461X NR 22 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 EI 1432-0630 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD DEC PY 2002 VL 74 SU S BP S557 EP S558 DI 10.1007/s003390101121 PN 1 PG 2 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 654MA UT WOS:000181499600186 ER PT J AU Tessier, PM Christesen, SD Ong, KK Clemente, EM Lenhoff, AM Kaler, EW Velev, OD AF Tessier, PM Christesen, SD Ong, KK Clemente, EM Lenhoff, AM Kaler, EW Velev, OD TI On-line spectroscopic characterization of sodium cyanide with nanostructured gold surface-enhanced Raman spectroscopy substrates SO APPLIED SPECTROSCOPY LA English DT Article DE surface-enhanced Raman spectroscopy; structured gold films; cyanide detection; colloidal crystal templating; nanoparticles ID NANOSPHERE LITHOGRAPHY; SILVER ELECTRODE; SCATTERING SERS; AG ELECTRODES; PROBES; MOLECULES; COLLOIDS; FILMS; CN AB To implement surface-enhanced Raman spectroscopy as a practical detection method, highly enhancing, stable, and reproducible substrates need to be fabricated in an efficient manner, and their performance in different solution environments should be well characterized. In this work structured porous gold films have been fabricated using colloidal crystals to template gold nanoparticles. These films were integrated into an on-line flow chamber and used to study the effects of pH and other additives on the detection of sodium cyanide. The gold films proved to be highly enhancing and were used to detect cyanide over a wide range of pH values in the concentration range of similar to2 to 200 ppb. The Raman signal intensity could be increased by lowering the pH after the adsorption of cyanide, which was likely due to both a change in the ionization state and a conformational change of the bound molecules. The peak intensity could also be enhanced multifold by treating the substrate with silver nitrate. Cyanide could be removed from the substrates using hydrochloric acid, although this also passivated the structures, and the activity could only be restored partially with tannic acid. These results provide a rational method to optimize the online detection of cyanide in water. C1 Univ Delaware, Dept Chem Engn, Ctr Mol & Engn Thermodynam, Newark, DE 19716 USA. USA, SBCCOM, Edgewood Chem Biol Ctr, Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. RP Velev, OD (reprint author), N Carolina State Univ, Riddick Engn Lab, Dept Chem Engn, Raleigh, NC 27695 USA. RI Velev, Orlin/A-2853-2008; OI Lenhoff, Abraham/0000-0002-7831-219X NR 38 TC 40 Z9 40 U1 1 U2 15 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD DEC PY 2002 VL 56 IS 12 BP 1524 EP 1530 DI 10.1366/000370202321115968 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 628TB UT WOS:000180011700003 ER PT J AU Drebot, MA Henchal, E Hjelle, B LeDuc, JW Repik, PM Roehrig, JT Schmaljohn, CS Shope, RE Tesh, RB Weaver, SC Calisher, CH AF Drebot, MA Henchal, E Hjelle, B LeDuc, JW Repik, PM Roehrig, JT Schmaljohn, CS Shope, RE Tesh, RB Weaver, SC Calisher, CH TI Improved clarity of meaning from the use of both formal species names and common (vernacular) virus names in virological literature SO ARCHIVES OF VIROLOGY LA English DT Editorial Material C1 Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. Canadian Sci Ctr Human & Anim Hlth, Populat & Publ Hlth Branch, Natl Microbiol Lab, Winnipeg, MB, Canada. USA, Med Res Inst Infect Dis, Div Virol, Dept Mol Virol, Frederick, MD 21701 USA. Univ New Mexico, Sch Med, Dept Pathol, Infect Dis & Inflammat Program, Albuquerque, NM 87131 USA. Univ New Mexico, Sch Med, Dept Biol, Infect Dis & Inflammat Program, Albuquerque, NM 87131 USA. Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Infect Dis & Inflammat Program, Albuquerque, NM 87131 USA. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30341 USA. NIAID, Div Microbiol & Infect Dis, Virol Branch, NIH, Bethesda, MD 20892 USA. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. Univ Texas, Med Branch, Dept Pathol, Ctr Trop Dis, Galveston, TX 77550 USA. RP Calisher, CH (reprint author), Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. RI Weaver, Scott/D-6490-2011; OI Roehrig, John/0000-0001-7581-0479 NR 3 TC 18 Z9 18 U1 0 U2 1 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PD DEC PY 2002 VL 147 IS 12 BP 2465 EP 2471 DI 10.1007/s00705-002-0938-8 PG 7 WC Virology SC Virology GA 625FF UT WOS:000179805800017 PM 12491112 ER PT J AU Tikuisis, P Keefe, AA Keillor, J Grant, S Johnson, RF AF Tikuisis, P Keefe, AA Keillor, J Grant, S Johnson, RF TI Investigation of rifle marksmanship on simulated targets during thermal discomfort SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE heat exposure; cold exposure; heat storage; heat debt; shooting performance ID SHOOTING PERFORMANCE; HEAT; TEMPERATURES; EXERCISE; STRESS; TASKS AB Background: Marksmanship has been reported to deteriorate during exposure to heat or cold, yet the effect of the resultant thermal strain in isolation of the inflicting thermal stress is not entirely clear. In most studies, the debilitating effects on marksmanship are confounded by an evolving thermal strain (in terms of body heat storage/debt). Hypothesis: Thermal strain (hot and cold) should degrade marksmanship, more with moving targets than with conventional pop-up targets that are deemed less challenging. Methods: The 12 rifle-trained military reservists (7 men and 5 women) were tested on their marksmanship skills using a small arms simulator. Subjects conducted three trials in an environmentally controlled chamber, 1 wk apart in a counter-balanced order. Trial conditions were neutral (N; 22degreesC), hot H; 35degreesC), and cold (C; 5degreesC), and all were preceded with an immersion in water to chest level to establish thermal strain (for H and C) or to maintain thermal neutrality prior to shooting. Subjects fired a C7 rifle at various targets during sixteen 5-min engagements over 2 h. Targets were presented either as moving in an urban setting or as pop-ups in a lane setting. Body temperatures, heart rate, saliva cortisol concentration, subjective ratings, and measures of marksmanship accuracy and precision were recorded and analyzed using a repeated measures design. Results: Mean +/- SD of the rectal temperature during the shooting were 36.9 +/- 0.2degreesC, 37.7 +/- 0.3degreesC, and 36.8 +/- 0.6degreesC for N, H, and C, respectively (H > N, C). Corresponding hand temperatures were 31.5 +/- 1.2degreesC, 35.2 +/- 0.7degreesC, and 19.4 +/- 3.0degreesC H > N > C). These body temperatures were consistent with the subjective indices of heat illness, cold discomfort, and muscle discomfort. Cortisol concentration and perceived exertion were higher during H Surprisingly, thermal strain did not degrade marksmanship. Instead, some aspects of precision (horizontal displacement) and accuracy (shooting error) were poorer during N compared with H and C. Conclusions: Deep body temperatures not higher than approximately 37.9degreesC and not less than 36.4degreesC (accompanied by hand temperatures of not less than 19degreesC) do not negatively affect rifle marksmanship performance, even if significant respective sensations of heat and cold are present. C1 Def Res & Dev Canada Toronto, Human Protect & Performance, Toronto, ON M3M 3B9, Canada. USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Tikuisis, P (reprint author), Def Res & Dev Canada Toronto, Human Protect & Performance, 1133 Sheppard Ave W,POB 2000, Toronto, ON M3M 3B9, Canada. NR 26 TC 16 Z9 17 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2002 VL 73 IS 12 BP 1176 EP 1183 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 623UA UT WOS:000179720200004 PM 12498545 ER PT J AU Catalan, J Moriguchi, T Slotnick, B Murthy, M Greiner, RS Salem, N AF Catalan, J Moriguchi, T Slotnick, B Murthy, M Greiner, RS Salem, N TI Cognitive deficits in docosahexaenoic acid-deficient rats SO BEHAVIORAL NEUROSCIENCE LA English DT Article ID POLYUNSATURATED FATTY-ACIDS; VISUAL-ACUITY DEVELOPMENT; OLFACTORY LEARNING-SET; TERM INFANTS; ARACHIDONIC-ACID; PRETERM INFANTS; ODOR DETECTION; BRAIN; DIET; OMEGA-3-FATTY-ACIDS AB This study investigated the influence of brain docosahexaenoic acid (DHA) deficiency on simple and complex olfactory-based learning and memory in 2nd generation (172) adult male rats. Rats raised and maintained on either an n-3-adequate or an n-3-deficient diet were tested for acquisition of an olfactory learning set and an olfactory memory task, and for motivation to obtain a water reward. Despite a 76% decrease in brain DHA, n-3-deficient rats were able to acquire most simple 2-odor discrimination tasks but were deficient in the acquisition of a 20-problem olfactory learning set. This deficit could not be attributed to changes in sensory capacity but, instead, appeared to represent a deficit in higher order,learning. C1 NIAAA, Lab Membrane Biochem & Biophys, Uniformed Serv Univ Hlth Sci, Sect Nutr Neurosci, Rockville, MD 20852 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. American Univ, Dept Psychol, Washington, DC 20016 USA. RP Salem, N (reprint author), NIAAA, Lab Membrane Biochem & Biophys, Uniformed Serv Univ Hlth Sci, Sect Nutr Neurosci, 12420 Parklawn Dr, Rockville, MD 20852 USA. RI Wilkinson, Stuart/C-2802-2013 NR 48 TC 109 Z9 122 U1 0 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0735-7044 J9 BEHAV NEUROSCI JI Behav. Neurosci. PD DEC PY 2002 VL 116 IS 6 BP 1022 EP 1031 DI 10.1037//0735-7044.116.6.1022 PG 10 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA 623EX UT WOS:000179691300009 PM 12492301 ER PT J AU Arciero, CA Shriver, CD Somiari, S Hooke, J Somiari, R Walter, R AF Arciero, CA Shriver, CD Somiari, S Hooke, J Somiari, R Walter, R TI Classification of breast disease by quantitative RT-PCR analysis of multiple transcripts in blood. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Windber Res Inst, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 402 BP S104 EP S104 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100300 ER PT J AU Ellsworth, DL Ellsworth, RE Deyarmin, B Mittal, V Lubert, S Shriver, CD Somiari, RI Windber, RI AF Ellsworth, DL Ellsworth, RE Deyarmin, B Mittal, V Lubert, S Shriver, CD Somiari, RI Windber, RI TI Loss of heterozygosity in normal tissue adjacent to primary breast carcinomas. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 183 BP S58 EP S58 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100118 ER PT J AU Ellsworth, RE Shriver, CD Ellsworth, DL Deyarmin, B Mittal, V Lubert, S Somiari, RI AF Ellsworth, RE Shriver, CD Ellsworth, DL Deyarmin, B Mittal, V Lubert, S Somiari, RI TI Loss of heterozygosity in premalignant lesions and 480 invasive tumors of the breast: examination of 26 commonly deleted chromosomal regions. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 479 BP S123 EP S123 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100374 ER PT J AU Schwartz, GH Steis, R Mathew, L Gilkerson, E Klein, P AF Schwartz, GH Steis, R Mathew, L Gilkerson, E Klein, P TI Patients with MBC prospectively selected by FISH derive clinical benefit from first-line treatment with Herceptin (R) plus a taxane. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Brooke Army Med Ctr, San Antonio, TX USA. Atlanta Canc Care, Roswell, GA USA. Lake Heart & Canc Med Ctr, Leesburg, FL USA. Genentech Inc, San Francisco, CA 94080 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 429 BP S111 EP S111 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100326 ER PT J AU Somiari, RI Sullivan, A Somiari, S Russell, S Malicki, L Arciero, C Hooke, J Shriver, C AF Somiari, RI Sullivan, A Somiari, S Russell, S Malicki, L Arciero, C Hooke, J Shriver, C TI High throughput global analysis of abnormalities associated with breast disease. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 24 BP S34 EP S34 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100025 ER PT J AU Somiari, SB Shriver, CD Garguilo, GA Heckman, CM Arcerio, C Hooke, J Somiari, RI AF Somiari, SB Shriver, CD Garguilo, GA Heckman, CM Arcerio, C Hooke, J Somiari, RI TI Matrix metalloproteinase 2 and 9 activity in blood of patients with breast disease and at risk for development of breast disease. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Mem Med Ctr, Johnstown, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 407 BP S105 EP S105 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100303 ER PT J AU Sullivan, AG Russell, S Jordan, R Hooke, J Shriver, C Somiari, RI AF Sullivan, AG Russell, S Jordan, R Hooke, J Shriver, C Somiari, RI TI High-throughput quantitative proteomics of human breast cancer tissue using 2D-differential in-gel electrophoresis and mass spectrometry. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 25th San Antonio Breast Cancer Symposium CY DEC 11-14, 2002 CL SAN ANTONIO, TEXAS C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 2 Z9 2 U1 1 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2002 VL 76 SU 1 MA 666 BP S164 EP S164 PG 1 WC Oncology SC Oncology GA 624QA UT WOS:000179770100531 ER PT J AU Graham, JS Schomacker, KT Glatter, RD Briscoe, CM Braue, EH Squibb, KS AF Graham, JS Schomacker, KT Glatter, RD Briscoe, CM Braue, EH Squibb, KS TI Efficacy of laser debridement with autologous split-thickness skin grafting in promoting improved healing of deep cutaneous sulfur mustard burns SO BURNS LA English DT Article DE sulfur mustard; laser debridement; skin grafting; wound contraction; image analysis ID PULSED CO2-LASER; CHEMICAL WARFARE; THERMAL-DAMAGE; ABLATION; TISSUE; INJURIES; LESIONS; MODEL AB The consequences of receiving a cutaneous sulfur mustard (SM) burn are prolonged wound healing and secondary infection. This study was undertaken to find a treatment that promotes quick healing with few complications and minimal disfigurement. Multiple deep SM burns (4 cm diameter) were generated on the ventrum of weanling pigs and treated at 48 h. Four treatments were compared: (1) full-thickness CO2 laser debridement followed by skin grafting; (2) full-thickness sharp surgical tangential excision followed by skin grafting, the "Gold Standard" used in deep thermal burns management; (3) partial-thickness laser ablation with no grafting; and (4) partial-thickness sharp excision with no grafting. A computer controlled, raster scanned, high-powered continuous wave (cw) CO2 laser was utilized. Ulceration, wound geometry, and wound contraction were evaluated during a 36-day healing period. Histopathological evaluations were conducted at the end of the healing period. Engraftment rates were similar between both methods of debridement. Laser debridement followed by skin grafting was as efficacious in improving the wound healing of deep SM burns as the "Gold Standard." Full-thickness laser debridement of these small total body surface area (TBSA) burns was time efficient and provided adequate beds for split-thickness skin grafting. Laser debridement offered additional benefits that included hemostatic control during surgery and minimal debridement of normal perilesional skin. Mid-dermal debridement by sharp excision or laser ablation without grafting produced less desirable results but was better than no treatment. Published by Elsevier Science Ltd and ISBI. C1 USA, Med Res Inst Chem Def, Comparat Pathol Branch, Div Comparat Med, Aberdeen Proving Ground, MD 21010 USA. Massachusetts Gen Hosp, Wellman Labs Photomed, Boston, MA 02114 USA. USA, Med Res Inst Chem Def, Adv Assessment Branch, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. Univ Maryland, Div Environm Epidemiol & Toxicol, Dept Epidemiol & Preventat Med, Baltimore, MD 21201 USA. RP Graham, JS (reprint author), USA, Med Res Inst Chem Def, Comparat Pathol Branch, Div Comparat Med, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. NR 46 TC 29 Z9 30 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD DEC PY 2002 VL 28 IS 8 BP 719 EP 730 AR PII S0305-4179(02)00198-5 DI 10.1016/S0305-4179(02)00198-5 PG 12 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 630ZN UT WOS:000180141900002 PM 12464469 ER PT J AU Srikantan, V Valladares, M Rhim, JS Moul, JW Srivastava, S AF Srikantan, V Valladares, M Rhim, JS Moul, JW Srivastava, S TI HEPSIN inhibits cell growth/invasion in prostate cancer cells SO CANCER RESEARCH LA English DT Article ID SURFACE SERINE-PROTEASE; EPITHELIAL-CELLS; HEPATOMA-CELLS; MICE DEFICIENT; FACTOR-VII; EXPRESSION; TRANSFORMATION; HYPERPLASIA AB Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP), has been highlighted by several studies analyzing CaP-specific gene expression alterations by cDNA microarray. Evaluations of the biological functions of HEPSIN in Cap cells are warranted for better assessment of its utility as a biomarker and/or therapeutic target. In stable clones of PC-3/HEPSIN transfectants, there was a dramatic reduction in the cell growth, cell invasion, and soft agar colony formation. A higher proportion of PC-3/HEPSIN cells were in the G2-M phase of the cell cycle, and there was also an increase in the cell population undergoing apoptosis. Preliminary analysis of HEPSIN transfections into LNCaP and DU145 cells further revealed cell growth-inhibitory effects. These results underscore that exogenous HEPSIN expression negatively regulates cell growth in metastatic Cap cell lines. Although the cause of the biological consequence of HEPSIN overexpression in primary CaP remains to be determined, the negative cell growth-regulatory effects of HEPSIN in metastatic CaP cells reported here have unraveled possible cellular and molecular mechanisms underlying observations that link decreased/loss of HEPSIN expression with poor prognosis of Cap. C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 34 TC 72 Z9 74 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 1 PY 2002 VL 62 IS 23 BP 6812 EP 6816 PG 5 WC Oncology SC Oncology GA 622HJ UT WOS:000179641000005 PM 12460890 ER PT J AU Walsh, ME Ramsey, CA Jenkins, TF AF Walsh, ME Ramsey, CA Jenkins, TF TI The effect of particle size reduction by grinding on subsampling variance for explosives residues in soil SO CHEMOSPHERE LA English DT Article DE TNT; RDX; heterogeneity; training ranges; sampling AB Efforts to characterize the surface soil contamination on military training ranges have been compromised by the inability to obtain representative subsamples of soils submitted to analytical laboratories for determination of explosives residues. Two factors affecting subsampling error for explosives residues were examined using soils collected from hand grenade and anti-tank ranges. These factors were increased subsample size and particle size reduction prior to subsampling of soils. Increasing the subsample size from 2 to 50 g did not reduce the soil subsampling error because of the extreme heterogeneous distribution of the solid contaminants. Alternatively, particle size reduction by machine grinding on a ring mill reduced subsampling error to less than 10% relative standard deviation for replicate analyses using 10-g subsamples. Published by Elsevier Science Ltd. C1 USA, Cold Reg Res & Engn Lab, Environm Sci Branch, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. Envirostat Inc, Ft Collins, CO 80522 USA. RP Walsh, ME (reprint author), USA, Cold Reg Res & Engn Lab, Environm Sci Branch, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. NR 22 TC 22 Z9 22 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD DEC PY 2002 VL 49 IS 10 BP 1267 EP 1273 AR PII S0045-6535(02)00528-3 DI 10.1016/S0045-6535(02)00528-3 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 619NL UT WOS:000179482400008 PM 12489723 ER PT J AU Perkins, PJ Morris, MJ AF Perkins, PJ Morris, MJ TI Vocal cord dysfunction induced by methacholine challenge testing SO CHEST LA English DT Article DE bronchoprovocation; direct laryngoscopy; exercise-induced asthma; methacholine challenge testing; vocal cord dysfunction ID EXERCISE-INDUCED ASTHMA; UPPER AIRWAY-OBSTRUCTION AB Study objectives: To determine whether methacholine challenge testing (MCT) provokes vocal cord dysfunction (VCD), as evidenced by inspiratory vocal cord closure on direct laryngoscopy, and whether spirometry and flow-volume loops (FVLs) demonstrate any changes that are suggestive of VCD. Design: Prospective, controlled study. Setting: Army medical center. Patients: Thirty-four subjects all with normal baseline spirometry. Ten subjects had documented evidence of VCD, 12 subjects had exercise-induced asthma (EIA) and reactive MCT, and 12 subjects served as healthy asymptomatic control subjects. Methods: Measurement of spirometry with FVLs and direct laryngoscopy of the vocal cords performed immediately before and after subjects had undergone MCT. Results: Evidence of inspiratory vocal cord adduction was found in four VCD patients. Two patients had adducted vocal cords at baseline, and their conditions were unchanged after undergoing MCT. Two other patients had normal conditions at baseline and demonstrated acute inspiratory vocal cord adduction after undergoing MCT. None of the patients in the EIA or control groups had evidence of VCD at baseline or after undergoing MCT. Truncation of the inspiratory limb of the FVL after MCT was noted in five patients, Which Correlated with evidence of VCD in 60% of these patients. One EIA patient had truncation of the inspiratory FVL after MCT, and no changes were found in the control group. A comparison of spirometry between EIA patients and VCD patients with and without evidence of inspiratory vocal cord adduction during MCT showed no significant differences. Conclusions: The findings suggest that MCT may cause an acute episode of vocal cord adduction and that positive results may not reflect underlying reactive airways disease. However, a flattening or truncation of the inspiratory FVL after the patient undergoes MCT is not diagnostic for the presence of inspiratory vocal cord adduction. C1 Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, Ft Sam Houston, TX 78234 USA. RP Perkins, PJ (reprint author), Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 27 TC 50 Z9 52 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD DEC PY 2002 VL 122 IS 6 BP 1988 EP 1993 DI 10.1378/chest.122.6.1988 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 628GV UT WOS:000179985600024 PM 12475837 ER PT J AU McClenathan, BM Torrington, KG Uyehara, CFT AF McClenathan, BM Torrington, KG Uyehara, CFT TI Family member presence during cardiopulmonary resuscitation - A survey of US and international critical care professionals SO CHEST LA English DT Article DE cardiopulmonary resuscitation; family-witnessed resuscitation; practice guidelines; survey ID INVASIVE PROCEDURES; RELATIVES; EXPERIENCE; EMERGENCY AB Objective: Recent international emergency cardiovascular care (ECC) and cardiopulmonary resuscitation (CPR) guidelines have recommended that health-care professionals allow family members to be present during resuscitation attempts. To assess whether critical care professionals support these recommendations, we surveyed health-care professionals for their opinions regarding family-witnessed resuscitation (MR). Methods: We surveyed health-care professionals attending the International Meeting of the American College of Chest Physicians in San Francisco, CA, from October 23 to 26, 2000, about their CPR experience, their opinions on FWR, and demographic characteristics. The opinions of physicians, nurses, and other allied health professionals were compared, and differences in opinions based on demographics were examined. Results: Five hundred ninety-two professionals were surveyed. Fewer physicians (20%) than nurses and allied health-care workers combined (39%) would allow family, member presence during adult CPR (p = 0.0037 [chi(2) test]). Fourteen percent of physicians and 17% of nurses would allow a family presence during pediatric CPR. There was a significant difference among the opinions of US professionals, based on regional location. Professionals practicing in the northeastern states were less likely than other US professionals to allow FWR during adult or pediatric resuscitations (p = 0.016 and p < 0.001, respectively [χ(2) test]). Midwestern professionals were more likely than others to allow family members to be present during an adult resuscitation, when compared to professional in the rest of the nation (p = 0.002 [χ(2) test]). Health-care professionals disapproving of family member presence during CPR did so because of the fear of psychological trauma to family members, performance anxiety affecting the CPR team, medicolegal concerns, and a fear of distraction to the resuscitation team. Conclusions: Our evaluation indicated that the majority or critical care professionals surveyed do not support the current recommendations provided by the ECC and CPR guidelines of 2000. C1 Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP McClenathan, BM (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 28 TC 85 Z9 89 U1 2 U2 9 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD DEC PY 2002 VL 122 IS 6 BP 2204 EP 2211 DI 10.1378/chest.122.6.2204 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 628GV UT WOS:000179985600051 PM 12475864 ER PT J AU Cooke, WH Convertino, VA AF Cooke, WH Convertino, VA TI Association between vasovagal hypotension and low sympathetic neural activity during presyncope SO CLINICAL AUTONOMIC RESEARCH LA English DT Article DE orthostatic tolerance; muscle sympathetic nerve activity; autonomic regulation ID SPACEFLIGHT; SYNCOPE; HUMANS; OUTFLOW; VAGAL AB Recent studies suggest that an underlying mechanism for susceptibility of patients and astronauts to presyncope includes hypoadrenergic responses to orthostatic stress. However, data used to reach this conclusion are open to various interpretations. In this report, maintenance of sympathetic neural activity (MSNA; peroneal nerve microneurography) during -60 mmHg lower body negative pressure (LBNP) was associated with maintenance of orthostatic tolerance, and disappearance of MSNA was associated with hypotension and pre-syncope. However, MSNA was substantially higher during progressive increases of negative pressure in the presyncopal subject, compared to the non-presyncopal subjects. The data from this case report question the notion that orthostatic hypotension occurs due to inadequate sympathetic neural activation during orthostatic stress in apparently normal, healthy subjects. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Michigan Technol Univ, Dept Biomed Engn, Houghton, MI 49931 USA. Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 16 TC 22 Z9 22 U1 0 U2 0 PU DR DIETRICH STEINKOPFF VERLAG PI DARMSTADT PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY SN 0959-9851 J9 CLIN AUTON RES JI Clin. Auton. Res. PD DEC PY 2002 VL 12 IS 6 BP 483 EP 486 DI 10.1007/s10286-002-0057-3 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 640TB UT WOS:000180703100016 PM 12598954 ER PT J AU Wirt, MD Nieves, NM Toney, MO AF Wirt, MD Nieves, NM Toney, MO TI Evaluation of brain perfusion using Tc-99m HMPAO in a patient with a persistent vegetative neurologic state and a left ventricular thrombus SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE cerebral infarction; magnetic resonance imaging; Tc-99m HMPAO ID ACUTE ISCHEMIC STROKE; PHOTON EMISSION CT; TOMOGRAPHY; MRI AB A 53 year-old man who had a large left hemispheric stroke was examined by computed tomography (CT) for a renal mass. A thrombus within the left ventricle was noted incidentally on CT. Because of the patient's vegetative neurologic status, a Tc-99m HMPAO perfusion scintigram was performed and showed significantly decreased perfusion within the left cerebral hemisphere. Magnetic resonance images revealed bilateral infarcts in the middle cerebral and left anterior cerebral artery distributions, with complete occlusion of the left supraclinoid carotid. The combination of CT, perfusion scintigram, and magnetic resonance imaging (MRI) facilitated a complete evaluation of the patient's vegetative state. C1 Tripler Army Med Ctr, Dept Nucl Med, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Wirt, MD (reprint author), Tripler Army Med Ctr, Dept Nucl Med, Honolulu, HI 96859 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD DEC PY 2002 VL 27 IS 12 BP 918 EP 919 DI 10.1097/01.RLU.0000037332.31738.7F PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 616XV UT WOS:000179329500026 PM 12607887 ER PT J AU Stroud, WJ Krishnamurthy, T Smith, SA AF Stroud, WJ Krishnamurthy, T Smith, SA TI Probabilistic and possibilistic analyses of the strength of a bonded joint SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES LA English DT Article DE bonded joint; probabilistic analysis; possibilistic analysis; fracture ID LAP-SHEAR SPECIMEN; ELEMENTS AB The effects of uncertainties on the predicted strength of a single lap shear joint are examined. Probabilistic and possibilistic methods are used to account for uncertainties. A total of ten variables are assumed to be random, with normal distributions. Both Monte Carlo Simulation and the First Order Reliability Method are used to determine the probability of failure. Triangular membership functions with upper and lower bounds located at plus or minus three standard deviations are used to model uncertainty in the possibilistic analysis. The alpha cut (or vertex) method is used to evaluate the possibility of failure. Linear and geometrically nonlinear finite element analyses are used calculate the response of the joint; fracture in the adhesive and material strength failure in the strap are used to evaluate its strength. Although probabilistic and possibilistic analyses provide significantly more information than do conventional deterministic analyses, they are computationally expensive. A novel scaling approach is-developed and used to substantially reduce the computational cost of the probabilistic and possibilistic analyses. The possibilistic approach for treating uncertainties appears to be viable during the conceptual and preliminary design stages when limited data are available and high accuracies are not needed. However, this viability is mixed with several cautions that are discussed herein. C1 USA, Res Lab, NASA,Langley Res ctr, Analyt & Computat Methods Branch,Vehicle Technol, Hampton, VA 23681 USA. RP Stroud, WJ (reprint author), USA, Res Lab, NASA,Langley Res ctr, Analyt & Computat Methods Branch,Vehicle Technol, Hampton, VA 23681 USA. NR 17 TC 10 Z9 10 U1 0 U2 1 PU TECH SCIENCE PRESS PI PALMDALE PA PO BOX 900486, PALMDALE, CA 93590-0486 USA SN 1526-1492 J9 CMES-COMP MODEL ENG JI CMES-Comp. Model. Eng. Sci. PD DEC PY 2002 VL 3 IS 6 BP 755 EP 772 PG 18 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 630AE UT WOS:000180084600006 ER PT J AU Ketzenberger, B Johnson, TE Van Gessel, YA Wild, SP Roach, WP AF Ketzenberger, B Johnson, TE Van Gessel, YA Wild, SP Roach, WP TI Study of corneal lesions induced by 1,318-nm laser radiation pulses in Dutch belted rabbits (Oryctolagus cuniculus) SO COMPARATIVE MEDICINE LA English DT Article AB Background and Purpose: Use of high-energy near-infrared lasers is becoming more prevalent in today's industries, such as technology, medicine, and military operations. Despite wide-range use of these lasers, threshold, median effective dose (ED50), and the mechanism of laser-tissue interaction are not well defined at the 1,318-nm wavelength for human corneal exposures. The goals of the study reported here were to establish the ED50 for single-pulse, 1,318-nm laser exposures on the Dutch Belted rabbit cornea and to characterize microscopic changes. Results of this study were then compared with those of previous corneal studies. Methods: A neodymium:yttrium aluminum garnet (Nd:YAG) laser was used to deliver single 1,318-nm wavelength pulses to the corneas of 10 female Dutch Belted rabbits (Oryctolagus cuniculus). Single pulses of 0.5-ms duration and radiant energy ranging from 116 to 2,250 J/cm(2) irradiated the exposure sites. Sites were clinically evaluated for presence of a lesion at one hour and 24-h after exposure. Results of the 24-h evaluation were used to determine the (ED50). Corneas were subsequently collected at the 24-h endpoint for microscopic evaluation. Results: The ED50 for 1,318-nm exposures to the rabbit cornea was determined to be 382 J/cm(2), as measured at the 1/e(2) (0.865 times that of the peak power per unit area). At each exposure site, there was a small (< 1 mm in diameter), white, circular, well demarcated corneal lesion characterized histologically by a band of stromal coagulative necrosis and endothelial necrosis, with sparing of the anterior epithelium. In addition, there appeared some potential for damage to Descemet's membrane at the highest energy level tested. Conclusions: Findings indicate that the rabbit cornea is subject to injury at the 1,318-nm wavelength with the established ED50. C1 Uniformed Serv Univ Hlth Sci, Dept Lab Anim Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Ketzenberger, B (reprint author), Uniformed Serv Univ Hlth Sci, Dept Lab Anim Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 17 TC 4 Z9 10 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD DEC PY 2002 VL 52 IS 6 BP 513 EP 517 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 637ZK UT WOS:000180543400006 PM 12540163 ER PT J AU Sun, W Tzeng, JT AF Sun, W Tzeng, JT TI Effective mechanical properties of EM composite conductors: an analytical and finite element modeling approach SO COMPOSITE STRUCTURES LA English DT Article DE effective modeling; homogenization; composites; unit cell ID OPTIMIZATION; DESIGN; HOMOGENIZATION AB An analytical model and numerical approach to predict the effective mechanical properties of a composite conductor consisting of metallic core and insulation layers are presented in this paper. The analytical model was developed based on a two-step homogenizations and mechanics analysis for composite unit cell. The Step I homogenization derives the effective properties of the out-wrapped composite insulation layers. The Step 2 homogenization further smears the metallic core and the effective composite insulation layers to develop homogenized mechanical properties for composite conductor according to appropriate homogenization sequences. The procedure of using numerical approach and finite element method to determine the unit cell effective constants were also described and the results of the FEA prediction were presented. The analytical predictions were compared well to the numerical results for the nine material constants that characterize the effective mechanical properties of the composite conductor. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sun, W (reprint author), Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA. NR 12 TC 6 Z9 8 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD DEC PY 2002 VL 58 IS 4 BP 411 EP 421 AR PII S0263-8223(02)00129-0 DI 10.1016/S0263-8223(02)00129-0 PG 11 WC Materials Science, Composites SC Materials Science GA 615NU UT WOS:000179253300002 ER PT J AU Hoffman, P AF Hoffman, P TI Response to Wayne Tyson 2002. "Producers and consumers of research" - Consuming research and closing the gap SO CONSERVATION ECOLOGY LA English DT Editorial Material C1 USA, Corps Engineers, Seattle Dist, Seattle, WA USA. RP Hoffman, P (reprint author), CENWS PM PL ER, POB 3755, Seattle, WA 98124 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU RESILIENCE ALLIANCE PI WOLFVILLE PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA SN 1195-5449 J9 CONSERV ECOL JI Conserv. Ecol. PD DEC PY 2002 VL 6 IS 2 AR r11 PG 2 WC Ecology SC Environmental Sciences & Ecology GA 735TH UT WOS:000186130300022 ER PT J AU Batchinsky, AI Cancio, LC Jordan, BS Cancelada, DA McManus, AT Goodwin, CW AF Batchinsky, AI Cancio, LC Jordan, BS Cancelada, DA McManus, AT Goodwin, CW TI Pathophysiology of hypoxia following pulmonary contusion: Role of ventilation-perfusion mismatch and of lesion volume SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 32nd Critical Care Congress CY JAN 28-FEB 02, 2003 CL SAN ANTONIO, TEXAS SP Soc Crit Care Med C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2002 VL 30 IS 12 SU S MA 382 BP A87 EP A87 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 633RM UT WOS:000180296300302 ER PT J AU Convertino, V Ryan, K AF Convertino, V Ryan, K TI Use of an inspiratory impedance threshold valve increases cardiac output in human volunteers SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 32nd Critical Care Congress CY JAN 28-FEB 02, 2003 CL SAN ANTONIO, TEXAS SP Soc Crit Care Med C1 USA, Inst Surg, Ft Sam Houston, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2002 VL 30 IS 12 SU S MA D BP A160 EP A160 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 633RM UT WOS:000180296300553 ER PT J AU Convertino, V Ryan, K AF Convertino, V Ryan, K TI Use of an inspiratory impedance threshold valve increases cardiac output in human volunteers SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 32nd Critical Care Congress CY JAN 28-FEB 02, 2003 CL SAN ANTONIO, TEXAS SP Soc Crit Care Med C1 USA, Inst Surg, Ft Sam Houston, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2002 VL 30 IS 12 SU S MA 311 BP A66 EP A66 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 633RM UT WOS:000180296300232 ER PT J AU Jackson, WL Shorr, AF AF Jackson, WL Shorr, AF TI The yield of lumbar puncture for nosocomial meningitis in the medical intensive care unit SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 32nd Critical Care Congress CY JAN 28-FEB 02, 2003 CL SAN ANTONIO, TEXAS SP Soc Crit Care Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2002 VL 30 IS 12 SU S MA 350 BP A78 EP A78 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 633RM UT WOS:000180296300270 ER PT J AU Weiss, W Batchinsky, A Cancio, LC Jordan, B McManus, A AF Weiss, W Batchinsky, A Cancio, LC Jordan, B McManus, A TI Spectral analysis of physiologic data discriminates survivors from non-survivors following trauma-hemorrhage SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 32nd Critical Care Congress CY JAN 28-FEB 02, 2003 CL SAN ANTONIO, TEXAS SP Soc Crit Care Med C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2002 VL 30 IS 12 SU S MA 214 BP A39 EP A39 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 633RM UT WOS:000180296300135 ER PT J AU Halstead, SB Lan, NT Myint, TT Shwe, TN Nisalak, A Kalyanarooj, S Nimmannitya, S Soegijanto, S Vaughn, DW Endy, TP AF Halstead, SB Lan, NT Myint, TT Shwe, TN Nisalak, A Kalyanarooj, S Nimmannitya, S Soegijanto, S Vaughn, DW Endy, TP TI Dengue hemorrhagic fever in infants: Research opportunities ignored SO EMERGING INFECTIOUS DISEASES LA English DT Article ID FELINE INFECTIOUS PERITONITIS; ANTIBODY-DEPENDENT ENHANCEMENT; VIRUS-INFECTION; MONOCLONAL-ANTIBODIES; MOLECULAR-BIOLOGY; DISEASE SEVERITY; PATHOGENESIS; MACROPHAGES; VIREMIA; IMMUNOPATHOGENESIS AB The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue infection. Progress studying the immunologically distinct infant DHF/IDSS has been limited; most contemporary research has centered on DHF/DSS accompanying secondary dengue infections. In designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. Research challenges presented by infant DHF/DSS are discussed. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Childrens Hosp No 1, Ho Chi Minh City, Vietnam. Yangon Childrens Hosp, Yangon, Myanmar. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Queen Sirkit Natl Inst Child Hlth, Bangkok, Thailand. Airlangga Univ, Dr Soetomo Hosp, Sch Med, Surabaya, Indonesia. RP Halstead, SB (reprint author), 5824 Edson Lane, Rockville, MD 20852 USA. EM halsteads@erols.com NR 41 TC 101 Z9 108 U1 2 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2002 VL 8 IS 12 BP 1474 EP 1479 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 625UQ UT WOS:000179834300018 PM 12498666 ER PT J AU Hooker, MS Schaefer, RA Fishbain, JT Belnap, CM AF Hooker, MS Schaefer, RA Fishbain, JT Belnap, CM TI Tuberculous tenosynovitis of the tibialis anterior tendon: A case report SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE tuberculous tenosynovitis; extrapulmonary tuberculosis; foot tumors; tibialis anterior tendon AB Tuberculous tenosynovitis is an uncommon form of extrapulmonary tuberculosis occurring primarily in the hands and wrists with limited reports involving the lower extremities. We report a rare case of tuberculous tenosynovitis of the tibialis anterior tendon occurring in a 37-year-old Filipino male. The tendon was surgically debrided and the patient was given a six month course of antituberculin chemotherapy. At one year postoperatively, the patient has good function with no evidence of recurrence. C1 USA, Dept Orthopaed, Washington, DC USA. USA, Dept Infect Dis, Washington, DC USA. USA, Dept Pathol, Washington, DC USA. RP Hooker, MS (reprint author), Tripler Army Med Ctr, Dept Orthopaed, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 17 TC 12 Z9 12 U1 0 U2 0 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD DEC PY 2002 VL 23 IS 12 BP 1131 EP 1134 PG 4 WC Orthopedics SC Orthopedics GA 626QK UT WOS:000179884300010 PM 12503806 ER PT J AU Kagan, FW AF Kagan, FW TI The Soviet military experience SO HISTORIAN LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Kagan, FW (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0018-2370 J9 HISTORIAN JI Historian PD WIN PY 2002 VL 64 IS 2 BP 461 EP 462 PG 2 WC History SC History GA 631EX UT WOS:000180156100069 ER PT J AU Frey, L AF Frey, L TI Interpreters as diplomats: A diplomatic history of the role of interpreters in world politics SO HISTORIAN LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Frey, L (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0018-2370 J9 HISTORIAN JI Historian PD WIN PY 2002 VL 64 IS 2 BP 473 EP 474 PG 2 WC History SC History GA 631EX UT WOS:000180156100080 ER PT J AU Cohen, M Cauwenberghs, G Vorontsov, MA AF Cohen, Marc Cauwenberghs, Gert Vorontsov, Mikhail A. TI Image Sharpness and Beam Focus VLSI Sensors for Adaptive Optics SO IEEE SENSORS JOURNAL LA English DT Article DE Adaptive optics; analog very large scale integration (VLSI); focal-plane image processing; image sensors; optical communication AB High-resolution wavefront control for adaptive optics requires accurate sensing of a measure of optical quality. We present two analog very-large-scale-integration (VLSI) image-plane sensors that supply real-time metrics of image and beam quality, for applications in imaging and line-of-sight laser communication. The image metric VLSI sensor quantifies sharpness of the received image in terms of average rectified spatial gradients. The beam metric VLSI sensor returns first and second order spatial moments of the received laser beam to quantify centroid and width. Closed-loop wavefront control of a laser beam through turbulence is demonstrated using a spatial phase modulator and analog VLSI controller that performs stochastic parallel gradient descent of the beam width metric. C1 [Cohen, Marc; Cauwenberghs, Gert] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Cohen, Marc; Vorontsov, Mikhail A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Vorontsov, Mikhail A.] USN, Res Lab, Adelphi, MD 20783 USA. [Cohen, Marc] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. RP Cohen, M (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. FU National Science Foundation [ECS-0010026] FX Manuscript received March 1, 2002; revised October 16, 2002. This research was funded by the National Science Foundation under Grant ECS-0010026. The associate editor coordinating the review of this paper and approving it for publication was Dr. Ralph Etienne-Cummings. NR 32 TC 15 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD DEC PY 2002 VL 2 IS 6 BP 680 EP 690 DI 10.1109/JSEN.2002.807298 PG 11 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA V23EU UT WOS:000208326900017 ER PT J AU Liu, ZJ He, JQ Xie, YJ Sullivan, A Carin, L AF Liu, ZJ He, JQ Xie, YJ Sullivan, A Carin, L TI Multilevel fast multipole algorithm for general targets on a half-space interface SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE fast multipole algorithm; Green's function; integral equations; method of moments (MoM) ID ELECTROMAGNETIC SCATTERING; INTEGRAL-EQUATIONS; ARBITRARY SHAPE; SURFACES AB The multilevel fast multipole algorithm (MLFMA) is considered for scattering from an electrically large conducting or dielectric target resting on the interface of a dielectric half-space. We focus on analysis of the half-space Green's function such that it is computed efficiently and accurately, while retaining a form that is-applicable to an MLFMA analysis. Attention is also directed toward development of a simple preconditioner to accelerate convergence of the conjugate-gradient solver. The utility of the model is examined for several applications, including scattering from an electrically large vehicle, trees, and rough dielectric interfaces in the presence of a dielectric half-space background. C1 Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Liu, ZJ (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. NR 19 TC 32 Z9 40 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD DEC PY 2002 VL 50 IS 12 BP 1838 EP 1849 DI 10.1109/TAP.2002.807425 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 647PH UT WOS:000181101800026 ER PT J AU Roy, S DeAnna, RG Zorman, CA Mehregany, M AF Roy, S DeAnna, RG Zorman, CA Mehregany, M TI Fabrication and characterization of polycrystalline SiC resonators SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE high temperature transducers; lateral resonant devices; microelectromechanical systems (MEMS); microsystems; polySiC; resonators; silicon carbide (SiC); surface micromachining ID CHEMICAL-VAPOR-DEPOSITION; FILMS; SILICON; THICK AB This paper presents the development of polycrystalline 3C silicon carbide (polySiC) lateral resonant devices, which are fabricated by a three-mask surface micromachining process using silicon dioxide (SiO2), polysilicon, and nickel (Ni) as the isolation, sacrificial, and contact metallization layers, respectively. The polySiC resonators are packaged for operation in high temperature environments using ceramic-based materials and nickel wirebonding procedures. Device operation is successfully demonstrated over <10(-5)-760 torr and 22-950 degreesC pressure and temperature ranges, respectively. Quality factors (Qs) of >100000 at <10(-5) torr and resonant frequency drifts of <18 ppm/h under continuous operation are achieved using an scanning electron microscope (SEM) setup. Device resonant frequency varies nonlinearly with increasing operating temperature. Finite element modeling reveals that this variation resulted from the interplay between the Young's modulus of polySiC and induced stresses, which occur due to mismatch in thermal expansion coefficients of the polySiC film and the underlying silicon (Si) substrate. C1 Cleveland Clin Fdn, Dept Biomed Engn, Cleveland, OH 44195 USA. NASA, Glenn Res Ctr Lewis Field, USA Res Lab, Vehicle Technol Ctr, Cleveland, OH 44135 USA. Case Western Reserve Univ, Dept Elect Engn & Comp Sci, Cleveland, OH 44106 USA. RP Cleveland Clin Fdn, Dept Biomed Engn, 9500 Euclid Ave, Cleveland, OH 44195 USA. EM roys@bme.ri.ccf.org OI Zorman, Christian/0000-0001-9773-9351 NR 22 TC 50 Z9 52 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD DEC PY 2002 VL 49 IS 12 BP 2323 EP 2332 DI 10.1109/TED.2002.807445 PG 10 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 645MR UT WOS:000180982000029 ER PT J AU Schulze, RA Willard, RJ Turiansky, GW AF Schulze, RA Willard, RJ Turiansky, GW TI Chronic palmar ulcer: a case of epithelioid sarcoma SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID FINE-NEEDLE ASPIRATION; DIAGNOSIS; DIFFERENTIATION C1 Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Turiansky, GW (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU BLACKWELL PUBLISHING LTD PI OXFORD PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD DEC PY 2002 VL 41 IS 12 BP 908 EP 910 DI 10.1046/j.1365-4362.2002.01654.x PG 3 WC Dermatology SC Dermatology GA 627FF UT WOS:000179922100024 PM 12492985 ER PT J AU Massie, DD AF Massie, DD TI Optimization of a building's cooling plant for operating cost and energy use SO INTERNATIONAL JOURNAL OF THERMAL SCIENCES LA English DT Article DE optimal control; thermal energy storage; chiller; cooling; least cost; minimize energy; neural network ID COLD-STORAGE; SYSTEM AB An optimal neural network-based controller for an ice thermal storage system has been developed and tested. The controller consists of four neural networks, three of which map equipment behavior and one that acts as a global controller. The controller self-learns equipment responses to the environment and then determines the control settings required to minimize operating cost. It has the advantage over other controllers in that it always remains calibrated. Since it does not rely upon rules or assumptions, it is able to provide optimal control under any utility pricing and operating condition. Although originally designed to minimize operating costs, simulation and optimization techniques often determine minimum energy use as well. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved. C1 US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. RP Massie, DD (reprint author), US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. NR 30 TC 16 Z9 16 U1 0 U2 1 PU EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS CEDEX 15 PA 23 RUE LINOIS, 75724 PARIS CEDEX 15, FRANCE SN 1290-0729 J9 INT J THERM SCI JI Int. J. Therm. Sci. PD DEC PY 2002 VL 41 IS 12 BP 1121 EP 1129 AR PII S1290-0729(02)01398-4 DI 10.1016/S1290-0729(02)01398-4 PG 9 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 626KJ UT WOS:000179871100003 ER PT J AU He, JK Innis, BL Shrestha, MP Clayson, ET Scott, RM Linthicum, KJ Musser, GG Gigliotti, SC Binn, LN Kuschner, RA Vaughn, DW AF He, JK Innis, BL Shrestha, MP Clayson, ET Scott, RM Linthicum, KJ Musser, GG Gigliotti, SC Binn, LN Kuschner, RA Vaughn, DW TI Evidence that rodents are a reservoir of hepatitis E virus for humans in Nepal (Retracted Article. See vol 44, pg 1208, 2006) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article; Retracted Publication ID SPORADIC ACUTE HEPATITIS; UNITED-STATES; MOLECULAR CHARACTERIZATION; PHYLOGENETIC ANALYSIS; CYNOMOLGUS MACAQUES; INDIAN STRAIN; E INFECTION; HEV; SEQUENCE; ISOLATE AB Hepatitis E virus (HEV) is an important cause of enterically transmitted hepatitis in developing countries. Sporadic autochthonous cases of hepatitis E have been reported recently in the United States and other industrialized countries. The source of HEV infection in these cases is unknown; zoonotic transmission has been suggested. Antibodies to HEV have been detected in many animals in areas where HEV is endemic and in domestic swine and rats in the United States. There is evidence supporting HEV transmission between swine and humans. Nevertheless, HEV has not been detected in wild rodents. We tested murid rodents and house shrews trapped in Nepal's Kathmandu Valley, where hepatitis E is hyperendemic, for HEV infection. The most commonly trapped species was Rattus rattus brunneusculus. Serum samples from 675 animals were tested for immunoglobulin G against HEV by enzyme-linked immunosorbent assay; 78 (12%) were positive, indicating acute or past infection. Antibody prevalence was higher among R. rattus brunneusculus and Bandicota bengalensis than in Suncus murinus. Forty-four specimens from 78 antibody-positive animals had sufficient residual volume for detection of HEV RNA (viremia) by reverse transcription-PCR. PCR amplification detected four animals (9%; three were R. rattus brunneusculus and one was B. bengalensis) with viremia. Phylogenetic analysis of the four genome sequences (405 bp in the capsid gene) recovered showed that they were identical, most closely related to two human isolates from Nepal (95 and 96% nucleotide homology, respectively), and distinct from HEV sequences isolated elsewhere. These data prove that certain peridomestic rodents acquire HEV in the wild and suggest that cross-species transmission occurs, with rodents serving as a virus reservoir for humans. C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Armed Forces Res Inst Med Sci, Res Unit, Walter Reed Army Inst Res, Kathmandu, Nepal. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Amer Museum Nat Hist, New York, NY 10024 USA. RP Vaughn, DW (reprint author), USA, Med Res & Mat Command, Mil Infect Dis Res Program, 504 Scott St, Ft Detrick, MD 21702 USA. EM david.vaughn@det.amedd.army.mil NR 39 TC 33 Z9 38 U1 4 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 2002 VL 40 IS 12 BP 4493 EP 4498 DI 10.1128/JCM.40.12.4493-4498.2002 PG 6 WC Microbiology SC Microbiology GA 622DP UT WOS:000179631500015 PM 12454141 ER PT J AU Hospenthal, DR Murray, CK Beckius, ML Green, JA Dooley, DP AF Hospenthal, DR Murray, CK Beckius, ML Green, JA Dooley, DP TI Persistence of pigment production by yeast isolates grown on CHROMagar Candida medium SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID PRESUMPTIVE IDENTIFICATION; CLINICAL SPECIMENS; DUBLINIENSIS; ALBICANS; SAMPLES AB We evaluated the persistence of pigmentation in yeast isolates grown on the chromogenic medium CHROMagar Candida over 7 days. Candida, Cryptococcus, and Trichosporon isolates were inoculated alone or mixed onto duplicate sets of plates and incubated at 30 and 35degreesC. Candida albicans and Candida krusei were readily identified throughout the reading period, but Candida glabrata was difficult to differentiate from other species until the 3- or 4-day time point. Candida tropicalis produced colonies similar to those of rare Cryptococcus and Trichosporon species, and mixed cultures were often difficult to identify as such. C1 Brooke Army Med Ctr, MCHE, MDI, Dept Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, MCHE, MDI, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 18 TC 23 Z9 24 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 2002 VL 40 IS 12 BP 4768 EP 4770 DI 10.1128/JCM.40.12.4768-4770.2002 PG 3 WC Microbiology SC Microbiology GA 622DP UT WOS:000179631500066 PM 12454192 ER PT J AU Wang, P Smith, ER Ebersole, BA AF Wang, P Smith, ER Ebersole, BA TI Large-scale laboratory measurements of longshore sediment transport under spilling and plunging breakers SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE longshore sediment transport; nearshore sediment transport; physical modeling; wave breaking; surf zone processes; sediment transport processes ID RANDOM BREAKING WAVES; SURF-ZONE TURBULENCE; FIELD-MEASUREMENTS; CURRENTS; BEACH; UNDERTOW; TRANSFORMATION; DYNAMICS; WATER; FORM AB Total rates and cross-shore distribution of longshore sediment transport under predominantly spilling and plunging breakers were examined in the Large-scale Sediment Transport Facility (LSTF) at the U.S. Army Engineer Research and Development Center. The input waves were long-crested unidirectional irregular waves with broad spectra. Taking advantage of the new state-of-the-art LSTF, a suite of parameters including wave height, longshore current, longshore sediment flux, sediment concentration, and their cross-shore distribution patterns were precisely measured. The main objective of this study was to quantify the influences of different forms of wave breaking on rates and patterns of longshore sediment transport. A significantly greater total rate of longshore sediment transport was measured under the plunging breakers than under the spilling breakers with similar breaker height. The peak longshore transport rate was measured in the swash zone for the spilling breaker case. In the case of plunging breakers, a bi-modal distribution pattern was measured with one peak in the swash zone and one in the vicinity of the breaker line. Similar rates of longshore transport were measured in the surf-bore dominated mid-surf zone for both cases. The suspended sediment concentration near the breaker line was approximately one order of magnitude greater under the plunging breakers than under the spilling breakers. Except in the inner surf zone, where faster current was measured during the plunging case, a similar cross-shore distribution of longshore current was measured for both plunging and spilling cases. Breaking type has significant influence on the magnitude and pattern of longshore transport. Parameters distinguishing dominant breaker types are important in improving the accuracy of longshore sediment transport predictions. C1 Univ S Florida, Dept Geol, Tampa, FL 32620 USA. USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Wang, P (reprint author), Univ S Florida, Dept Geol, Tampa, FL 32620 USA. NR 67 TC 33 Z9 33 U1 4 U2 11 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 2002 VL 18 IS 1 BP 118 EP 135 PG 18 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 524HJ UT WOS:000174006900011 ER PT J AU Hughes, SA AF Hughes, SA TI Equilibrium cross sectional area at tidal inlets SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE tidal inlets; tidal prism; equilibrium area; movable-bed models; scale relationships; inlet equilibrium AB A relationship is derived between the tidal prism passing through an inlet and the inlet throat minimum cross-sectional area. The form of the new relationship closely resembles previous empirical formulations. The main assumption in the derivation is that the maximum discharge per unit width through an inlet is at equilibrium with every depth across the minimum cross section. The derived relationship matches data from 102 U.S. inlets as well as results from 18 small-scale movable-bed models, whereas previous empirical relationships failed to match the laboratory data. The new relationship between tidal prism and equilibrium cross-sectional area is used to derive now scaling relationships for movable-bed tidal inlet laboratory models. The scaling assures that the relative balance between the turbulent shear stress acting on the bottom and the critical shear stress of the bud material is the same in the model as in prototype. These scaling relationships will allow quantitative results of complicated inlet processes to be obtained from properly operated small-scale movable-bed inlet models. C1 USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Hughes, SA (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 23 TC 28 Z9 28 U1 0 U2 1 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 2002 VL 18 IS 1 BP 160 EP 174 PG 15 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 524HJ UT WOS:000174006900014 ER PT J AU Leamy, MJ Wasfy, TM AF Leamy, MJ Wasfy, TM TI Transient and steady-state dynamic finite element Modeling of belt-drives SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME LA English DT Article ID MULTIBODY SYSTEMS; FRICTION; VIBRATION; SLIP AB In this study, a dynamic finite element model is developed for pulley belt-drive systems and is employed to determine the transient and steady-state response of a prototypical belt-drive. The belt is modeled using standard truss elements, while the pulleys are modeled using rotating circular constraints, for which the driver pulleys angular velocity is prescribed. Frictional contact between the pulleys and the belt is modeled using a penalty formulation with frictional contact governed by a Coulomb-like tri-linear friction law One-way clutch elements are modeled using a proportional torque law supporting torque transmission in a single direction. The dynamic response of the drive is then studied by incorporating the model into an explicit finite element code, which can maintain time-accuracy for large rotations and for long simulation times. The finite element solution is validated through comparison to an exact analytical solution of a steadily-rotating, two-pulley drive. Several response quantities are compared, including the normal and tangential (friction) force distributions between the pulleys and the belt, the driven pulley angular velocity, and the belt span tensions. Excellent agreement is found. Transient response results,for a second belt-drive example involving a one-way clutch are used to demonstrate the utility and flexibility of the finite element solution approach. C1 US Mil Acad, W Point, NY 10996 USA. Adv Sci & Automat Corp, Hampton, VA 23666 USA. RP Leamy, MJ (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 27 TC 52 Z9 56 U1 0 U2 7 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-0434 J9 J DYN SYST-T ASME JI J. Dyn. Syst. Meas. Control-Trans. ASME PD DEC PY 2002 VL 124 IS 4 BP 575 EP 581 DI 10.1115/1.1513793 PG 7 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA 632PR UT WOS:000180232400010 ER PT J AU Sloop, JC Bumgardner, CL Loehle, WD AF Sloop, JC Bumgardner, CL Loehle, WD TI Synthesis of fluorinated heterocycles SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article DE fluorination; pyrazole; isoxazole; pyrimidine; quinoline ID BETA-DIKETONES; TRIFLUOROMETHYL AB Selected 1,3-diketones having a trifluoromethyl group and/or a fluorine in the 2-position were condensed with aromatic hydrazines, hydroxylamine, urea, thiourea, guanidine, and substituted anilines producing pyrazoles, isoxazoles, pyrimidines, and quinolines, respectively, in yields ranging from 27 to 87%. (C) 2002 Elsevier Science B.V. All rights reserved. C1 N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. US Mil Acad, Dept Chem, W Point, NY 10996 USA. RP Sloop, JC (reprint author), US Mil Acad, Dept Chem, 646 Swift Rd, W Point, NY 10996 USA. EM jcsloop2@aol.com OI Sloop, Joseph/0000-0001-7639-0234 NR 26 TC 122 Z9 122 U1 1 U2 11 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD DEC 1 PY 2002 VL 118 IS 1-2 BP 135 EP 147 AR PII S0022-1139(02)00221-X DI 10.1016/S0022-1139(02)00221-X PG 13 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 621WM UT WOS:000179614100018 ER PT J AU Barrett, A Cardello, A Maguire, P Defao, A Taub, I AF Barrett, A Cardello, A Maguire, P Defao, A Taub, I TI Physical and sensory properties of meatstick products as affected by formulation and drying: Sensory-instrumental relationships SO JOURNAL OF FOOD QUALITY LA English DT Article ID LOW-FAT FRANKFURTERS; TEXTURE-MODIFYING INGREDIENTS; GLASS-TRANSITION; BOLOGNA SAUSAGE; SUGAR MIXTURES; CELLULOSE GUMS; IMAGE-ANALYSIS; REDUCED FAT; WATER; STARCH AB Shelf-stable meats are of interest to industry and are important in military ration development. Stability is commonly achieved through control of pH and water activity. However, reduction in moisture as a means to lower a(w) can significantly affect texture. Other ingredients, such as fat, can also potentially affect texture and possibly mitigate hardening due to lowered moisture. Meatsticks dried to three water activities, 0.88, 0.90, and 0.92, each from batters at three fat levels, 14, 17, and 21%, were produced, yielding products varying in both moisture and fat content. Products were subjected to mechanical and sensory testing and image and color analysis. Meatstick modulus, shear force, L* value, and percent of area of cut surfaces covered by separated fat were correlated with sensory assessments of interior hardness, hardness with skin, color, and visual fat, respectively. These parameters were significantly influenced by composition, particularly fat and protein contents and fat-protein interaction. C1 USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA. Goodmark Foods, Garner, NC 28365 USA. RP Barrett, A (reprint author), USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA. EM Ann.Barrett@natick.army.mil NR 34 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0146-9428 J9 J FOOD QUALITY JI J. Food Qual. PD DEC PY 2002 VL 25 IS 6 BP 499 EP 518 DI 10.1111/j.1745-4557.2002.tb01043.x PG 20 WC Food Science & Technology SC Food Science & Technology GA 637GT UT WOS:000180503900003 ER PT J AU Liston, GE Sturm, M AF Liston, GE Sturm, M TI Winter precipitation patterns in arctic Alaska determined from a blowing-snow model and snow-depth observations SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID COMPLEX TERRAIN; TRANSPORT MODEL; LOCAL ADVECTION; ENERGY-BALANCE; SEASONAL SNOW; SUBLIMATION; HYDROLOGY; SNOWDRIFT; PROFILES; ACCURACY AB A blowing-snow model (SnowTran-3D) was combined with field measurements of end-of-winter snow depth and density to simulate solid (winter) precipitation, snow transport, and sublimation distributions over a 20 000-km 2 arctic Alaska domain. The domain included rolling uplands and a flat coastal plain. Simulations were produced for the winters of 1994/95, 1995/96, and 1996/97. The model, which accounts for spatial and temporal variations in blowing-snow sublimation, as well as saltation and turbulent-suspended transport, was driven with interpolated fields of observed temperature, humidity, and wind speed and direction. Model outputs include local (a few hundreds of meters) to regional (several tens of kilometers) distributions of winter snow-water-equivalent depths and blowing-snow sublimation losses, from which the regional winter precipitation distributions are computed. At regional scales, the end-of-winter snow depth is largely equal to the difference between winter precipitation and moisture loss due to sublimation. While letting SnowTran-3D simulate the blowing-snow sublimation fluxes, the precipitation fields were determined by forcing the regional variation in model-simulated snow depths to match measured values. Averaged over the entire domain and the three simulation years, the winter precipitation was 17.6 cm, with uplands values averaging 19.0 cm and coastal values averaging 15.3 cm. On average, 21% of the precipitation was returned to the atmosphere by blowing-snow sublimation, while in the windier coastal regions 34% of the winter precipitation sublimated. C1 Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Liston, GE (reprint author), Colorado State Univ, Dept Atmospher Sci, Ft Collins, CO 80523 USA. NR 48 TC 105 Z9 107 U1 0 U2 13 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2002 VL 3 IS 6 BP 646 EP 659 DI 10.1175/1525-7541(2002)003<0646:WPPIAA>2.0.CO;2 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 625JV UT WOS:000179814100003 ER PT J AU Tolnay, M Vereshchagina, LA Tsokos, GC AF Tolnay, M Vereshchagina, LA Tsokos, GC TI NF-kappa B regulates the expression of the human complement receptor 2 gene SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HUMAN LYMPHOCYTES-B; C3D RECEPTOR; TRANSCRIPTIONAL ACTIVATION; B/REL PROTEINS; CD21 GENE; PROMOTER; BINDING; CR-2; DIFFERENTIATION AB CR2 is a key regulator of the B cell response to Ag. Here we show that NF-kappaB enhances the expression of the human CR2 gene. Promoter truncation, deletion, and mutagenesis studies indicated a functional role for a consensus NF-kappaB promoter element, as well as a heterogeneous nuclear ribonucleoprotein D element and an overlapping X box/E box. By supershift analysis, the first two elements bound NF-kappaB p50 and p65 and heterogeneous nuclear ribonucleoprotein RNP D, respectively. The X box/E box bound regulatory factor X5 and, surprisingly, NF-kappaB p50 and p65. Overexpression of NF-kappaB p50 enhanced the activity of the CR2 promoter in B cell lines and primary B cells, suggesting a direct role for NF-kappaB in regulating promoter activity. Importantly, mutation of the NF-kappaB element or the X box/E box rendered the promoter unresponsive to NF-kappaB p50. Using chromatin immunoprecipitation in live B cell lines and primary B cells, we found that NF-kappaB proteins p50, p65, and c-Rel bound to the genomic promoter at two locations that overlap with the consensus NF-kappaB element or the X box/E box. Finally, stimuli that activate NF-kappaB enhanced the activity of the CR2 promoter, and LPS rapidly increased the number of CR2 proteins on the surface of primary B cells. We propose that the NF-kappaB signaling pathway enhances the expression of the CR2 gene, as a result of NF-kappaB proteins binding to two CR2 promoter elements. Thus, at the onset of an infection, LPS could sensitize the B cell to Ag by enhancing the level of CR2-costimulatory molecules on the cell surface. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Tolnay, M (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, 503 Robert Grant Ave,Bldg 503,Room 1A32, Silver Spring, MD 20910 USA. FU NIAID NIH HHS [R01-AI42782] NR 42 TC 18 Z9 19 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 2002 VL 169 IS 11 BP 6236 EP 6243 PG 8 WC Immunology SC Immunology GA 619LX UT WOS:000179478400021 PM 12444129 ER PT J AU Litvin, FL Vecchiato, D Demenego, A Karedes, E Hansen, B Handschuh, R AF Litvin, FL Vecchiato, D Demenego, A Karedes, E Hansen, B Handschuh, R TI Design of one stage planetary gear train with improved conditions of load distribution and reduced transmission errors SO JOURNAL OF MECHANICAL DESIGN LA English DT Article ID BEHAVIOR AB The authors propose an approach for the design of one-stage planetary gear train with reduced transmission errors, localized bearing contact and improved conditions of distribution of load between the planetary gears. The planetary gear train is considered as a multi-body mechanical system of rigid bodies. The proposed approach is based: (i) on modification of geometry of gear tooth surfaces, and (ii) minimization and equalization of the backlash between the contacting gear tooth surfaces. The modification of geometry is accomplished: (i) by double-crowning of planetary gears, and (ii) by application of screw involute surfaces of the same direction of screws for the sun and the ring gears. The proposed geometry enables: (i) predesign of parabolic function of transmission errors for reduction of noise and vibration, and (ii) a simple method of regulation and equalization of the backlash between the gear tooth. C1 Univ Illinois, Gear Res Ctr, Chicago, IL 60607 USA. Sikorsky Aircraft Co, Stratford, CT 06615 USA. NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. Army Res Lab, Cleveland, OH 44135 USA. RP Litvin, FL (reprint author), Univ Illinois, Gear Res Ctr, Chicago, IL 60607 USA. NR 15 TC 15 Z9 16 U1 3 U2 11 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD DEC PY 2002 VL 124 IS 4 BP 745 EP 752 DI 10.1115/1.1515797 PG 8 WC Engineering, Mechanical SC Engineering GA 625RR UT WOS:000179829800018 ER PT J AU Chunduru, S Kawami, H Gullick, R Monacci, WJ Dougherty, G Cutler, ML AF Chunduru, S Kawami, H Gullick, R Monacci, WJ Dougherty, G Cutler, ML TI Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas SO JOURNAL OF NEURO-ONCOLOGY LA English DT Article DE Rsu-1; glioma; glioblastoma; RNA; splicing; exon skipping ID TUMOR-SUPPRESSOR; HUMAN GLIOBLASTOMAS; SACCHAROMYCES-CEREVISIAE; ADENYLYL CYCLASE; GENE; GROWTH; EXPRESSION; CANCER; CHROMOSOME-10; MUTATIONS AB Previous studies demonstrated that the Ras suppressor, RSU-1, localizes to human chromosome 10p13, a region frequently deleted in high grade gliomas, and that RSU-1 expression inhibited the tumorigenesis of a glioblastoma cell line. We have now examined RNA from human glial tumors for RSU-1 expression by RT-PCR using primers for the 5' and 3' ends of the RSU-1 open reading frame. Analysis of the amplified RSU-1 cDNA demonstrated that in addition to the entire 858 bp RSU-1 open reading frame, a shorter 725 bp RSU-1 fragment was amplified as well. Sequencing of this product revealed that it encoded a RSU- 1 cDNA product which was missing a single 133 bp internal exon. This exon-deleted product was found in 30% of the high grade gliomas studied and 2/3 oligodendrogliomas, but not in other CNS tumors, bladder or colon tumors or normal tissue. The exon-deleted RSU-1 product was infrequently detected in RNA from human tumor cell lines. Expression of an HA-tagged form of the deleted RSU-1 protein in transfected Cos 1 cells revealed that the protein was unstable, with a half life of less than 1 h, in contrast to the full length HA-tagged Rsu-1 protein which was stable for more than 4 h. These results suggest that the alternative splicing of the RSU-1 RNA to produce the exon-deleted form constitutes a mechanism for reduction or loss of functional Rsu-1. Because the expression of Rsu-1 can inhibit malignant growth of glioblastoma cells, the depletion of Rsu-1, via the production of the alternatively spliced form of RSU-1, may inhibit growth regulation in tumors. C1 Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. Hiroshima Univ, Dept Surg, Hiroshima, Japan. Walter Reed Army Med Ctr, Div Neurosurg, Washington, DC 20307 USA. RP Cutler, ML (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pathol, Room B3121,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 42 TC 12 Z9 12 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-594X J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD DEC PY 2002 VL 60 IS 3 BP 201 EP 211 DI 10.1023/A:1021130620178 PG 11 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 616PP UT WOS:000179312400001 PM 12510772 ER PT J AU Wang, XX Qin, ZH Leng, Y Wang, YM Jin, XN Chase, TN Bennett, MC AF Wang, XX Qin, ZH Leng, Y Wang, YM Jin, XN Chase, TN Bennett, MC TI Prostaglandin A(1) inhibits rotenone-induced apoptosis in SH-SY5Y cells SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE caspase-3; dopaminergic cell; mitochondrial complex I; nuclear factor-kappa B; Parkinson's disease; prostaglandin A1 ID NF-KAPPA-B; PARKINSONS-DISEASE; DOPAMINERGIC-NEURONS; CYCLOPENTENONE PROSTAGLANDINS; ACTIVATION; HSP27; HSP70; PHOSPHORYLATION; MITOCHONDRIA; EFFECTOR AB The degeneration of nigral dopamine neurons in Parkinson's disease (PD) reportedly involves a defect in brain mitochondrial complex I in association with the activation of nuclear factor-kappaB (NF-kappaB) and caspase-3. To elucidate molecular mechanisms possibly linking these events, as well as to evaluate the neuroprotective potential of the cyclopentenone prostaglandin A(1) (PGA(1)), an inducer of heat shock proteins (HSPs), we exposed human dopaminergic SH-SY5Y cells to the complex I inhibitor rotenone. Dose-dependent apoptosis was preceded by the nuclear translocation of NF-kappaB and then the activation of caspase-3 over the ensuing 24 h. PGA(1) increased the expression of HSP70 and HSP27 and protected against rotenone-induced apoptosis, without increasing necrotic death. PGA(1) blocked the rotenone-induced nuclear translocation of NF-kappaB and attenuated, but did not abolish, the caspase-3 elevation. Unexpectedly, the caspase-3 inhibitor, Ac-DEVD.CHO (DEVD), at a concentration that completely prevented the caspase-3 elevation produced by rotenone, failed to protect against apoptosis. These results suggest that complex I deficiency in dopamine cells can induce apoptosis by a process involving early NF-kappaB nuclear translocation and caspase-3 activation. PGA, appears to protect against rotenone-induced cell death by inducing HSPs and blocking nuclear translocation of NF-kappaB in a process that attenuates caspase-3 activation, but is not mediated by its inhibition. C1 NINDS, Expt Therapeut Branch, Bethesda, MD 20892 USA. Massachusetts Gen Hosp, Boston, MA 02114 USA. Harvard Univ, Sch Med, Lab Cellular & Neurobiol, Boston, MA USA. Walter Reed Army Inst Res, Dept Biol, Div Expt Therapeut, Silver Spring, MD USA. Blanchette Rockefeller Neurosci Inst, Rockville, MD USA. RP Chase, TN (reprint author), NINDS, Expt Therapeut Branch, Bldg 10,Room 5C-103,10 Ctr Dr MSC 1604, Bethesda, MD 20892 USA. NR 48 TC 59 Z9 64 U1 1 U2 4 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD DEC PY 2002 VL 83 IS 5 BP 1094 EP 1102 DI 10.1046/j.1471-4159.2002.01224.x PG 9 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 621CR UT WOS:000179571400008 PM 12437580 ER PT J AU Kukhtarev, N Kukhtareva, T Edwards, ME Penn, B Frazier, D Abdeldayem, H Banerjee, PP Hudson, T Friday, WA AF Kukhtarev, N Kukhtareva, T Edwards, ME Penn, B Frazier, D Abdeldayem, H Banerjee, PP Hudson, T Friday, WA TI Photoinduced optical and electrical high-voltage pulsations and pattern formation in photorefractive crystals SO JOURNAL OF NONLINEAR OPTICAL PHYSICS & MATERIALS LA English DT Article DE optical pulsator; photorefractive crystals; dynamic pattern formation ID MODELS AB We review our results on conversion of CW laser Ar-ion beam power into pulsating multichannel outputs: optical, electric and piezoelectric with simultaneous dynamic pattern formation. We show, that electrical pulsations generate high-voltage signals that may be used as a driving voltage for the conventional electro-optical modulator. We have also demonstrated the possibility of synchronization of two optical pulsators, through regulated optical coupling in a photorefractive LiNbO3 crystal. Spatial distribution of scattered light is self-organized in different patterns (hexagonal and cross-type). C1 Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. NASA, George C Marshall Space Flight Ctr, Space Sci Lab, Huntsville, AL 35812 USA. NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. Univ Dayton, Dept ECE, Dayton, OH 45469 USA. USA, Aviat & Missile Command, Redstone Arsenal, AL 35898 USA. RP Kukhtarev, N (reprint author), Alabama A&M Univ, Dept Phys, POB 1268, Normal, AL 35762 USA. NR 16 TC 12 Z9 12 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 912805, SINGAPORE SN 0218-8635 J9 J NONLINEAR OPT PHYS JI J. Nonlinear Opt. Phys. Mater. PD DEC PY 2002 VL 11 IS 4 BP 445 EP 453 DI 10.1142/S0218863502001164 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA 649QM UT WOS:000181219500009 ER PT J AU Wax, MK Winslow, CP Andersen, PE AF Wax, MK Winslow, CP Andersen, PE TI Use of allogenic dermis for radial forearm free flap donor site coverage SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Western Section of the Triological-Society CY JAN 06-07, 2001 CL CARLSBAD, CALIFORNIA SP Triol Soc, Western Sect DE Alloderm (R); allogenic dermis; free flap; radial forearm; split-thickness skin graft ID MORBIDITY; COMPLICATIONS AB Objective: The radial forearm free flap has become the method of choice for reconstruction of head and neck defects following oncologic ablation. Harvesting of a radial forearm free flap leaves a donor site defect. This is most commonly closed with a split-thickness skin graft. Morbidity, most commonly owing to a lack of graft take over the tendons, can be quite high. Recently, an acellular matrix (Alloderm(R)) has been advocated to decrease complications at the radial forearm donor site, as well as obviate taking a split-thickness skin graft from the thigh. Material and Methods: Tertiary referral academic centre. Retrospective chart review of 15 patients. Five patients received allogenic dermis, 10 patients received split-thickness skin grafting to the radial forearm donor site. Results: Patients with allogenic dermis took between 12 and 16 weeks to heal completely. Patients undergoing split-thickness skin graft were completely healed within 4 to 6 weeks. Cosmesis was judged to be marginally better in the allogenic dermis group. Allogenic dermis placement had a greater impact on hand function owing to prolonged healing, whereas patients with split-thickness skin graft required wound care at the thigh for a 2- to 3-week period owing to the harvesting of the skin graft. Conclusions: Allogenic dermis may be a viable alternative to split-thickness skin grafting and radial forearm free flap donor sites. Prolonged healing with subsequent increased health care services use needs to be addressed. C1 Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Wax, MK (reprint author), Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, 3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA. NR 16 TC 20 Z9 22 U1 2 U2 2 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD DEC PY 2002 VL 31 IS 6 BP 341 EP 345 DI 10.2310/7070.2002.34423 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 642DY UT WOS:000180790000003 PM 12593544 ER PT J AU Boyer, SL Johansen, JR Flechtner, VR Howard, GL AF Boyer, SL Johansen, JR Flechtner, VR Howard, GL TI Phylogeny and genetic variance in terrestrial Microcoleus (Cyanophyceae) species based on sequence analysis of the 16s rRNA gene and associated 16S-23S ITS region SO JOURNAL OF PHYCOLOGY LA English DT Article DE 16S rRNA; cyanobacteria; ITS; microbiotic crusts; Microcoleus; operon variation; phylogeny; rRNA sequence data ID CRYPTOGAMIC SOIL CRUSTS; RIBOSOMAL-RNA; TRANSCRIBED SPACER; MICROBIOTIC CRUSTS; COLORADO PLATEAU; CYANOBACTERIA; RECOVERY; STRAINS; DESERT; ALGAE AB Thirty-one strains of Microcoleus were isolated from desert soils in the United States. Although all these taxa fit the broad definition of Microcoleus vaginatus (Vaucher) Gomont in common usage by soil algal researchers, sequence data for the 16S rRNA gene and 16S-23S internal transcribed spacer (ITS) region indicated that more than one species was represented. Combined sequence and morphological data revealed the presence of two morphologically similar taxa, M. vaginatus and Microcoleus steenstrupii Boye-Petersen. The rRNA operons of these taxa were sufficiently dissimilar that we suspect the two taxa belong in separate genera. The M. vaginatus clade was most similar to published sequences from Trichodesmium and Arthrospira. When 16S sequences from the isolates we identified as M. steenstrupii were compared with published sequences, our strains grouped with M. chthonoplastes (Mertens) Zanardini ex Gomont and may have closest relatives among several genera in the Phormidiaceae. Organization within the 16S-23S ITS regions was variable between the two taxa. Microcoleus vaginatus had either two tRNA genes (tRNA(Ile) and tRNA(Ala) ) or a fragment of the tRNA(Ile) gene in its ITS regions, whereas M. steenstrupii had rRNA operons with either the tRNA(Ile) gene or no tRNA genes in its ITS regions. Microcoleus vaginatus showed no subspecific variation within the combined morphological and molecular characterizations, with 16S similarities ranging from 97.1% to 99.9%. Microcoleus steenstrupii showed considerable genetic variability, with 16S similarities ranging from 91.5% to 99.4%. In phylogenetic analyses, we found that this variability was not congruent with geography, and we suspect that our M. steenstrupii strains represent several cryptic species. C1 John Carroll Univ, Dept Biol, Cleveland, OH 44118 USA. USA, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Boyer, SL (reprint author), John Carroll Univ, Dept Biol, 20700 N Park Blvd, Cleveland, OH 44118 USA. RI Johansen, Jeff/F-5616-2011 NR 61 TC 78 Z9 88 U1 0 U2 18 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0022-3646 J9 J PHYCOL JI J. Phycol. PD DEC PY 2002 VL 38 IS 6 BP 1222 EP 1235 DI 10.1046/j.1529-8817.2002.01168.x PG 14 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 627CG UT WOS:000179910900018 ER PT J AU Cohen, SP Larkin, T Polly, TW AF Cohen, SP Larkin, T Polly, TW TI A giant herniated disc following intradiscal electrothermal therapy SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE complication; discogenic pain; herniated nucleus pulposus; internal disc disruption; intradiscal electrothermal therapy ID BACK-PAIN AB The introduction of intradiscal electrothermal therapy for the management of discogenic back pain has been met with intense interest over the past few years. During this time there have been several noncontrolled studies published on the procedure, most of which have shown excellent outcomes but few, if any, complications. The authors describe a 29-year-old, 152-kg active duty male soldier who underwent two-level intradiscal electrothermal therapy for L4-L5 and L5-S1 discogenic pain. Before the procedure, the patient had a small L5-S1 contained herniation, with no signs of radiculitis. Postprocedure, the patient developed radicular symptoms and was noted on MRI to have a large L5-S1 disc herniation effacing the left S I nerve root. Follow-up discography revealed a negative discogram at L4-L5. The patient proceeded to undergo a single-level lumbar fusion, which resulted in nearly complete relief of his radicular and axial low back pain. Two years post-surgery, he is off all narcotic medications and continues to work full-time as a soldier. This case illustrates both the potential benefits and complications that may be associated with intradiscal electrothermal therapy. C1 Walter Reed Army Med Ctr, Dept Anesthesiol, Pain Management Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Orthoped Surg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Washington, DC USA. RP Cohen, SP (reprint author), NYU, Sch Med, Dept Anaesthesiol, 550 1st Ave, New York, NY 10016 USA. NR 10 TC 18 Z9 18 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD DEC PY 2002 VL 15 IS 6 BP 537 EP 541 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 624VF UT WOS:000179781900019 PM 12468986 ER PT J AU Pecor, JE Harbach, RE Peyton, EL Roberts, DR Rejmankova, E Manguin, S Palanko, J AF Pecor, JE Harbach, RE Peyton, EL Roberts, DR Rejmankova, E Manguin, S Palanko, J TI Mosquito studies in Belize, Central America: Records, taxonomic notes, and a checklist of species SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Culicidae; mosquitoes; checklist; Belize; distribution; bionomics ID ANOPHELES-PSEUDOPUNCTIPENNIS; BRITISH-HONDURAS; LARVAL HABITATS; SOUTH-AMERICA; CULICIDAE; DIPTERA; MALARIA; ELEVATION; SUBGENERA; DARLINGI AB Data from mosquito collections made in Belize, Central America, between September 1990 and April 1993 are presented. A total of 537 collections yielding 15,139 specimens are summarized. One genus, 4 subgenera, and 31 species are recorded from Belize for the 1st time. A checklist of the 111 mosquito species now known to occur in Belize is presented. C1 Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. Nat Hist Museum, Dept Entomol, London SW7 5BD, England. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Univ Calif Davis, Dept Environm Sci & Policy, Davis, CA 95616 USA. Epidemiol Res Ctr, Belize City, Belize. RP Pecor, JE (reprint author), Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RI Manguin, Sylvie/G-1787-2015 OI Manguin, Sylvie/0000-0002-5925-7164 NR 63 TC 11 Z9 12 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2002 VL 18 IS 4 BP 241 EP 276 PG 36 WC Entomology SC Entomology GA 747ZU UT WOS:000186837500002 PM 12542181 ER PT J AU Sardelis, MR Turell, MJ O'Guinn, ML Andre, RG Roberts, DR AF Sardelis, MR Turell, MJ O'Guinn, ML Andre, RG Roberts, DR TI Vector competence of three North American strains of Aedes albopictus for West Nile virus SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes albopictus; West Nile virus; vector competence; extrinsic incubation ID YELLOW-FEVER VIRUS; GEOGRAPHIC STRAINS; UNITED-STATES; ENCEPHALITIS-VIRUS; ORAL INFECTION; DENGUE VIRUSES; CULEX-PIPIENS; CULICIDAE; AEGYPTI; DIPTERA AB To evaluate the potential for North American (NA) Aedes albopictus to transmit West Nile virus (WN), mosquito strains derived from 3 NA sources (Frederick County, Maryland, FRED strain; Cheverly, MD, CHEV strain; Chambers and Liberty counties, Texas, TAMU strain) were tested. These strains were tested along with a previously tested strain from a Hawaiian source (OAHU strain). Mosquitoes were fed on 2- to 3-day-old chickens previously inoculated with a New York strain (Crow 397-99) of WN. All of the NA strains were competent laboratory vectors of WN, with transmission rates of 36, 50, 83, and 92% for the FRED, CHEV, OAHU, and TAMU strains, respectively. The extrinsic incubation period for WN in Ae. albopictus held at 26degreesC was estimated to be 10 days. Based on efficiency of viral transmission, evidence of natural infection, bionomics, and distribution, Ae. albopictus could be an important bridge vector of WN in the southeastern USA. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Div Trop Publ Hlth, Bethesda, MD 20814 USA. USA, Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, Frederick, MD 21702 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, 1425 Porter St, Frederick, MD 21702 USA. NR 33 TC 66 Z9 71 U1 1 U2 9 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2002 VL 18 IS 4 BP 284 EP 289 PG 6 WC Entomology SC Entomology GA 747ZU UT WOS:000186837500005 PM 12542184 ER PT J AU Nasci, RS Gottfried, KL Burkhalter, KL Kulasekera, VL Lambert, AJ Lanciotti, RS Hunt, AR Ryan, JR AF Nasci, RS Gottfried, KL Burkhalter, KL Kulasekera, VL Lambert, AJ Lanciotti, RS Hunt, AR Ryan, JR TI Comparison of Vero cell plaque assay, TaqMan (R) reverse transcriptase polymerase chain reaction RNA assay, and VecTest (TM) antigen assay for detection of West Nile virus in field-collected mosquitoes SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE West Nile virus; surveillance; TaqMan (R); reverse transcriptase polymerase chain reaction; plaque assay; VecTest (TM); enzyme immunoassay; mosquito; vector ID CAPTURE ENZYME-IMMUNOASSAY; ST-LOUIS ENCEPHALITIS; NEW-YORK; RAPID DETECTION; INFECTION; POOLS; BIRDS; PCR AB Mosquitoes collected during the epidemic of West Nile virus (WN) in Staten Island, NY, during 2000 were identified to species, grouped into pools of up to 50 individuals, and tested for the presence of WN by using TaqMan((R)) reverse transcriptase polymerase chain reaction (RT-PCR) to detect West Nile viral RNA, Vero cell plaque assay to detect infectious virus, and VecTest(TM) WNV/SLE Antigen Panel Assay. A total of 10,866 specimens was tested in 801 pools. Analysis of results indicated that TaqMan RT-PCR detected 34 WN-positive pools, more than either of the other techniques. The plaque assay detected 74% of the pools positive by TaqMan, and VecTest detected 60% of the pools positive by TaqMan. The VecTest assay detected evidence of West Nile viral antigen in 67% of the pools that contained live virus detected by plaque assay. A WN enzyme immunoassay performed similarly to the VecTest WN assay. Differences in performance were related to relative sensitivity of the tests. Infection rates of WN in Culex pipiens and Cx. salinarius calculated by the 3 techniques varied, but each estimate indicated a high infection rate in the population. Positive and negative attributes of each procedure, which may influence how and where they are used in surveillance programs, are discussed. C1 Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. New York City Dept Hlth, Amherst, MA 01003 USA. Walter Reed Army Inst Res, Dept Entomol, Div Commun Dis & Immunol, Silver Spring, MD 20910 USA. RP Nasci, RS (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, POB 2087, Ft Collins, CO 80522 USA. NR 21 TC 57 Z9 60 U1 0 U2 8 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2002 VL 18 IS 4 BP 294 EP 300 PG 7 WC Entomology SC Entomology GA 747ZU UT WOS:000186837500007 PM 12542186 ER PT J AU Bucci, JR Matsumoto, CS Swanson, SJ Agodoa, LYC Holtzmuller, KC Peters, TG Abbott, KC AF Bucci, JR Matsumoto, CS Swanson, SJ Agodoa, LYC Holtzmuller, KC Peters, TG Abbott, KC TI Donor hepatitis C seropositivity: Clinical correlates and effect on early graft and patient survival in adult cadaveric kidney transplantation SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ANTIBODY-POSITIVE DONORS; STAGE RENAL-DISEASE; VIRUS-INFECTION; ORGAN-TRANSPLANTATION; UNITED-STATES; RECIPIENTS; IMPACT; TRANSMISSION; CANDIDATES; DIALYSIS AB The impact of hepatitis C virus-positive donor kidneys on patient survival has not been analyzed in a national study. This study analyzed 20,111 adult (age, greater than or equal to16 yr) recipients having solitary cadaveric kidney transplants from adult donors with valid donor hepatitis C serologies from July 1, 1994, to June 30, 1998, in an historical cohort study (the 2000 United States Kidney Data System) of patient survival. Analysis was by the Cox proportional hazards models, which corrected for characteristics thought to affect outcomes. Of 484 kidneys positive for hepatitis C virus serology, 165 (34%) were given to recipients with confirmed negative hepatitis C serologies. Unadjusted 3-yr patient survival was 93% in all recipients of donor hepatitis C-negative kidneys versus 85% in all recipients of donor hepatitis C-positive kidneys (P = 0.01). Among hepatitis C-positive recipients, those who received hepatitis C-positive kidneys had worse survival than recipients of hepatitis C-negative kidneys. Among elderly hepatitis C-negative recipients, those who received hepatitis C-positive kidneys also had worse survival; in fact, all recipients of donor hepatitis C-positive kidneys had increased risk of mortality (P = 0.028). There were no significant interactions between donor hepatitis C positivity and either recipient hepatitis C positivity or older recipient age. The use of hepatitis C-positive kidneys in recipients who were hepatitis C-negative was fairly common and contrary to some current recommendations. Recipients of donor hepatitis C-positive kidneys were at independently increased risk of mortality, with no evidence that any subgroups were less affected. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Sch Hlth Sci, Bethesda, MD USA. WRAMC, Organ Transplant Serv, Washington, DC USA. NIH, Bethesda, MD 20892 USA. NIDDKD, NIH, Bethesda, MD 20892 USA. WRAMC, Gastroenterol Serv, Washington, DC USA. Jacksonville Transplant Ctr Shands, Jacksonville, FL USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 42 TC 48 Z9 48 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD DEC PY 2002 VL 13 IS 12 BP 2974 EP 2982 DI 10.1097/01.ASN.0000034944.90425.75 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 618HT UT WOS:000179413200018 PM 12444217 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI Understanding formation of solid electrolyte interface film on LiMn2O4 electrode SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID PROPYLENE CARBONATE; GRAPHITE-ELECTRODES; SPINEL; INTERCALATION; BATTERIES; CELLS; TRANSITION; BEHAVIOR; OXIDES AB We studied formation of solid electrolyte interface (SEI) film on the surface of spinel LiMn2O4 electrodes by evaluating irreversible capacity and monitoring impedance change in the first charge and discharge cycle of a Li/LiMn2O4 cell. Results show that during the first cycle, LiMn2O4 produces 10-15% irreversible capacity in both 1 m LiPF6 3:7 ethylene carbonate/ethyl methyl carbonate (EC/EMC) and 1 m LiPF6 1:1:3 propylene carbonate (PC)/EC/EMC electrolytes. Formation of the irreversible capacity mainly takes place in two voltage regions of similar to3.1 V, near open-circuit voltage of a fresh cell, and 3.7-4.2 V, in the voltage range of delithiation and lithiation of LiMn2O4. It is believed that the irreversible capacity is associated with the formation of SEI film on the surface of LiMn2O4 electrode. Impedance data indicate that electrolyte solvents greatly affect properties of the SEI film. The SEI film formed with PC/EC/EMC electrolyte is more resistive and more stable, while that formed with EC/EMC electrolyte is subjected to a reversible breakdown at voltages higher than 3.8 V. It is observed that after the cell is cycled, the SEI film becomes more conductive while the bulk resistance of electrolyte and electrode increases. (C) 2002 The Electrochemical Society. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 21 TC 60 Z9 60 U1 3 U2 50 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD DEC PY 2002 VL 149 IS 12 BP A1521 EP A1526 DI 10.1149/1.1516220 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 616DP UT WOS:000179286700004 ER PT J AU Dastrup, B AF Dastrup, B TI Fort Sisseton SO JOURNAL OF THE WEST LA English DT Book Review C1 US Army Field Artillery Sch, Ft Sill, OK USA. RP Dastrup, B (reprint author), US Army Field Artillery Sch, Ft Sill, OK USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU J WEST INC PI MANHATTAN PA P O BOX 1009, MANHATTAN, KS 66505-1009 USA SN 0022-5169 J9 J WEST JI J. West PD WIN PY 2002 VL 41 IS 1 BP 99 EP 99 PG 1 WC History SC History GA 516HV UT WOS:000173548600040 ER PT J AU Abbott, KC Oglesby, RJ Agodoa, LY AF Abbott, KC Oglesby, RJ Agodoa, LY TI Hospitalized avascular necrosis after renal transplantation in the United States SO KIDNEY INTERNATIONAL LA English DT Article; Proceedings Paper CT AST 2000 Meeting CY 2000 CL CHICAGO, ILLINOIS SP AST DE osteonecrosis; hip; total hip arthroplasty; kidney rejection; year of transplant; complications; USRDS; bone pain post-transplant ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; PROSPECTIVE-PAYMENT SYSTEM; ASEPTIC NECROSIS; RISK-FACTORS; CORTICOSTEROID-THERAPY; BONE NECROSIS; FEMORAL-HEAD; OSTEONECROSIS; RECIPIENTS; HYPERPARATHYROIDISM AB Background. The national incidence of and risk factors for hospitalized avascular necrosis (AVN) in renal transplant recipients has not been reported. Methods. This historical cohort study consisted of 42,096 renal transplant recipients enrolled in the United States Renal Data System (USRDS) between 1 July 1994 and 30 June 1998. The data source was USRDS files through May 2000. Associations with hospitalizations for a primary diagnosis of AVN (ICD-9 codes 733.4x) within three years after renal transplant were assessed in an intention-to-treat design by Cox regression analysis. Results. Recipients had a cumulative incidence of 7.1 episodes/1000 person-years from 1994 to 1998. The two-year incidence of AVN did not change significantly over time. Eighty-nine percent of the cases of AVN were due to AVN of the hip (733.42) and 60.2% of patients with AVN underwent total hip arthroplasty (THA); these percentages did not change significantly over time. In the Cox regression analysis, an earlier year of transplant, African American race [adjusted hazard ratio (AHR), 1.65, 95% confidence interval (CI) 1.33 to 2.03], allograft rejection (AHR 1.67, 95% CI 1.35 to 2.07), peritoneal dialysis (vs. hemodialysis; AHR 1.44, 95% CI 1.15 to 1.81), and diabetes (AHR 0.41, 95% CI 0.27 to 0.64) were the only factors independently associated with hospitalizations for AVN. Conclusions. The incidence of AVN did not decline significantly over time in the renal transplant population. Patients with allograft rejection, African American race, peritoneal dialysis and earlier date of transplant were at the highest risk of AVN, while diabetic recipients were at a decreased risk. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NIDDKD, NIH, Bethesda, MD 20892 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dial Nephrol Serv, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 46 TC 22 Z9 24 U1 0 U2 1 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD DEC PY 2002 VL 62 IS 6 BP 2250 EP 2256 DI 10.1046/j.1523-1755.2002.00667.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 617DV UT WOS:000179346600037 PM 12427153 ER PT J AU Arnholt, JL Mair, EA AF Arnholt, JL Mair, EA TI A 'third hand' for endoscopic skull base surgery SO LARYNGOSCOPE LA English DT Article; Proceedings Paper CT Meeting of the Southern-Section of the Triological-Society CY JAN 10-12, 2002 CL CAPTIVA ISL, FLORIDA SP Triol Soc, SO Sect ID PITUITARY C1 Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. RP Mair, EA (reprint author), Wilford Hall USAF Med Ctr, Dept Otolaryngol, 2200 Bergquist Dr,Suite 1, San Antonio, TX 78236 USA. NR 8 TC 14 Z9 14 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2002 VL 112 IS 12 BP 2244 EP 2249 DI 10.1097/00005537-200212000-00021 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 624JE UT WOS:000179755900021 PM 12461348 ER PT J AU Minyard, CM AF Minyard, CM TI Armed conflict: The lessons of modern warfare. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Mt Pleasant, MI USA. RP Minyard, CM (reprint author), USA, Mt Pleasant, MI USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 2002 VL 127 IS 20 BP 152 EP 153 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 624JT UT WOS:000179757100221 ER PT J AU Mullins, WM Crane, RL AF Mullins, WM Crane, RL TI Modeling and quantification of corroded surfaces SO MATERIALS EVALUATION LA English DT Article DE corrosion; probability of failure; aerospace maintenance; life prediction; aging aircraft AB An overall framework for incorporation of corrosion models into probability of failure models for the system is outlined. The approach uses the results of stochastic kinetic models for corrosion evolution to determine the morphology of the affected region. From this morphology, associated local stresses are calculated. This distribution of local stresses is then used with classical fatigue models to predict system probability of failure. As such, corrosion can then be considered as a generalized damage with a quantifiable damage parameter and a relationship between this parameter and the measurable physical properties of the affected regions. C1 USA, Res Off, Mat Sci Directorate, Res Triangle Pk, NC 27709 USA. Air Force Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. RP Mullins, WM (reprint author), USA, Res Off, Mat Sci Directorate, Res Triangle Pk, NC 27709 USA. NR 28 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC NON-DESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD DEC PY 2002 VL 60 IS 12 BP 1452 EP 1458 PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA 622JB UT WOS:000179643000008 ER PT J AU Choe, JY AF Choe, JY TI Luminescence and compositional analysis of Y3Al5O12 : Ce films fabricated by pulsed-laser deposition SO MATERIALS RESEARCH INNOVATIONS LA English DT Article DE YAG : Ce; thin-films; pulsed-laser deposition (PLD); photoluminescence; EDX ID ACTIVATED GARNET PHOSPHORS; THIN-FILMS; CRYSTALS AB Y3-xAl5O12:Ce-x(3+) (YAG:Ce3+) thin-films were deposited by a pulsed-laser deposition method on quartz substrates using a solid YAG:Ce target. The films were analyzed by X-ray diffraction, scanning electron microscopy, photoluminescence (PL), and energy dispersive X-ray analysis (EDX). The as-deposited films were amorphous and annealing above 900 degreesC was required for crystallization. PL spectra of annealed films showed a strong and broad emission band around 570 nm and excitations at 342 and 460 nm, all corresponding to transitions between the 4f(1) ground level to the 5d(1) excited levels of Ce3+ ion. Chemical analysis of films by EDX resulted in nearly the same information as that of the target illustrating excellent stoichiometry replication of the film from the target being sputtered. C1 USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA. RP Choe, JY (reprint author), USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA. NR 16 TC 18 Z9 18 U1 1 U2 11 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 1432-8917 J9 MATER RES INNOV JI Mater. Res. Innov. PD DEC PY 2002 VL 6 IS 5-6 BP 238 EP 241 DI 10.1007/s10019-002-0204-4 PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA 637CF UT WOS:000180493500005 ER PT J AU Evans, RK Knight, KL Draper, DO Parcell, AC AF Evans, RK Knight, KL Draper, DO Parcell, AC TI Effects of warm-up before eccentric exercise on indirect markers of muscle damage SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE active warm-up; passive warm-up; diathermy; muscle temperature; muscle soreness ID SKELETAL-MUSCLE; TEMPERATURE-CHANGES; DEEP MUSCLES; INJURY; CONTRACTIONS; PREVENTION; BEHAVIOR; HUMANS AB Purpose: To test whether active and passive warm-up conducted before eccentric exercise attenuates clinical markers of muscle damage. Methods: Untrained subjects were exposed to one of five conditions: low-heat passive warm-up (N = 10), high-heat passive warm-up (N = 4), or active warm-up (N = 9), preceding eccentric exercise; eccentric exercise without warm-up (N = 10); or high-heat passive warm-up without eccentric exercise (N = 10). Passive warm-up of the elbow flexors was achieved using pulsed short-wave diathermy, and active warm-up was achieved by concentric contraction. Creatine kinase (CK) activity, strength, range of motion, swelling, and muscle soreness were observed before treatment (baseline) and 24, 48, 72, and 168 h after treatment. Results: High-heat passive warm-up without eccentric exercise did not affect any marker of muscle damage and was used as our control group. Markers of muscle damage were not different between groups that did or did not conduct warm-up before eccentric exercise. The active warm-up and eccentric groups exhibited a greater circumferential increase than controls (P < 0.0002), however, that was not observed after passive warm-up. Additionally, the active warm-up group exhibited a greater CK response than controls at 72 h (P < 0.05). The high-heat passive warm-up before eccentric exercise group exhibited significant change from controls at the least number of time points, but due to a small sample size (N = 4), these data should be viewed as preliminary. Conclusion: Our observations suggest that passive warm-up performed before eccentric exercise may be more beneficial than active warm-up or no warm-up in attenuating swelling but does not prevent, attenuate, or resolve more quickly the other clinical symptoms of eccentric muscle damage as produced in this study. C1 Brigham Young Univ, Coll Hlth & Human Performance, Provo, UT 84602 USA. RP Evans, RK (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 42 Kansas St, Natick, MA 01760 USA. NR 33 TC 33 Z9 33 U1 1 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 2002 VL 34 IS 12 BP 1892 EP 1899 DI 10.1249/01.MSS.0000038895.14935.C8 PG 8 WC Sport Sciences SC Sport Sciences GA 624JV UT WOS:000179757300006 PM 12471293 ER PT J AU Castellani, JW AF Castellani, JW TI Symposium: Immune function in environmental extremes - an introduction SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material ID CARBOHYDRATE; EXERCISE; EXERTION C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Castellani, JW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. NR 7 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 2002 VL 34 IS 12 BP 2002 EP 2003 DI 10.1249/01.MSS.0000038975.76196.89 PG 2 WC Sport Sciences SC Sport Sciences GA 624JV UT WOS:000179757300021 PM 12471308 ER PT J AU Castellani, JW Brenner, IKM Rhind, SG AF Castellani, JW Brenner, IKM Rhind, SG TI Cold exposure: human immune responses and intracellular cytokine expression SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE antarctica; exercise; hypothermia; natural killer cells; shivering ID HUMAN THERMOREGULATORY RESPONSES; CELL-MEDIATED-IMMUNITY; PERIOPERATIVE HYPOTHERMIA; WOUND-INFECTION; WATER IMMERSION; EXERCISE; RELEASE; STRESS; SYSTEM; LIPOPOLYSACCHARIDE AB It is commonly believed that exposure to cold environmental temperatures depresses immune function and increases the risk for infection. This review paper will 1) present an overview of human physiological responses to cold exposure, 2) present the human studies examining the effects of cold exposure on immune responses, and 3) summarize recent experiments from our laboratories examining the effects of exercise and fatigue on immune responses during subsequent cold exposure. Based on the review of the literature, there is no support for the concept that cold exposure depresses immune function. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. Trent Univ, Peterborough, ON K9J 7B8, Canada. Def & Civil Inst Environm Med, Toronto, ON M3M 3B9, Canada. RP Castellani, JW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. NR 67 TC 27 Z9 29 U1 3 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 2002 VL 34 IS 12 BP 2013 EP 2020 DI 10.1249/01.MSS.0000041400.21166.79 PG 8 WC Sport Sciences SC Sport Sciences GA 624JV UT WOS:000179757300023 PM 12471310 ER PT J AU Foreman, MM AF Foreman, MM TI Military capital litigation: Meeting the heightened standards of United States v. Curtis SO MILITARY LAW REVIEW LA English DT Article ID EFFECTIVE ASSISTANCE; COUNSEL; ACCESS; TRIAL C1 USA, Off Judge Advocate Gen, Washington, DC 20310 USA. RP Foreman, MM (reprint author), USA, Off Judge Advocate Gen, Washington, DC 20310 USA. NR 28 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 1 EP 46 PG 46 WC Law SC Government & Law GA 659ZE UT WOS:000181808600001 ER PT J AU Burgess, HL AF Burgess, HL TI The admissibility of post-offense uncharged misconduct to prove character SO MILITARY LAW REVIEW LA English DT Article ID GOOD SOLDIER DEFENSE C1 USA, Command & Gen Staff Coll, Mil Law Off, Ft Leavenworth, KS USA. RP Burgess, HL (reprint author), USA, Command & Gen Staff Coll, Mil Law Off, Ft Leavenworth, KS USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 47 EP 91 PG 45 WC Law SC Government & Law GA 659ZE UT WOS:000181808600002 ER PT J AU Milliard, TS AF Milliard, TS TI An autumn of war: What America learned from September 11 and the war on terrorism SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Milliard, TS (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 143 EP 154 PG 12 WC Law SC Government & Law GA 659ZE UT WOS:000181808600005 ER PT J AU Tomer, Y AF Tomer, Y TI No one left behind: The Lieutenant Commander Michael Scott Speicher story SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Tomer, Y (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 155 EP 163 PG 9 WC Law SC Government & Law GA 659ZE UT WOS:000181808600006 ER PT J AU Graff, PC AF Graff, PC TI The secrets of inchon SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Graff, PC (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 164 EP 172 PG 9 WC Law SC Government & Law GA 659ZE UT WOS:000181808600007 ER PT J AU Daknis, WP AF Daknis, WP TI Killing Pablo: The hunt for the world's greatest outlaw SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Daknis, WP (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 173 EP 179 PG 7 WC Law SC Government & Law GA 659ZE UT WOS:000181808600008 ER PT J AU Behan, CW AF Behan, CW TI Judge advocates in combat: Army lawyers in military operations from Vietnam to Haiti SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Behan, CW (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 180 EP 188 PG 9 WC Law SC Government & Law GA 659ZE UT WOS:000181808600009 ER PT J AU Burger, SJ AF Burger, SJ TI Why terrorism works: Understanding the threat, responding to the challenge SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Burger, SJ (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 189 EP 194 PG 6 WC Law SC Government & Law GA 659ZE UT WOS:000181808600010 ER PT J AU Hagler, JC AF Hagler, JC TI Raider SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Hagler, JC (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD DEC PY 2002 VL 174 BP 195 EP 200 PG 6 WC Law SC Government & Law GA 659ZE UT WOS:000181808600011 ER PT J AU Reynolds, K Cosio-Lima, L Creedon, J Gregg, R Zigmont, T AF Reynolds, K Cosio-Lima, L Creedon, J Gregg, R Zigmont, T TI Injury occurrence and risk factors in construction engineers and combat artillery soldiers SO MILITARY MEDICINE LA English DT Article ID BODY-MASS INDEX; PREVENTION; OBESITY; OVERWEIGHT; INDUSTRY; WOMEN; MEN AB Objectives: This 1-year prospective study compared 125 construction engineers and 188 combat artillery soldiers to determine whether there were differences in injury occurrences/types because of their diverse occupational tasks and training requirements. Also, intrinsic factors were studied to establish any associations with a soldier's risk for injury. Methods: Prestudy height, weight, and body mass index and fitness (3.2-km run, sit-ups, push-ups) data were collected prior to the injury medical records review. Approximately 30% of each battalion was studied. Results: For engineers and artillery, 86.0% and 66.0% incurred at least one injury, respectively. Of total soldiers, 64.0% of engineers and 56.4% of artillerymen had injuries associated with limited duty profiles. Total injuries resulted in 743 days of limited duty time (5.9 days per soldier) in engineers and, 1,078 days (5.7 days per soldier) in artillery. Odds ratios (OR) and 95% confidence intervals (CI) were also calculated. The odds of traumatic fractures were (OR = 6.5, 95% CI = 1.8-23.7) 6 times higher in engineers than artillery, but strains/sprains and abrasions/lacerations were (OR = 2.3, 95% CI = 1.5-3.7; OR = 2.5, 95% CI = 1.2-5.0) two times higher in artillery than engineers. The number of limited duty days associated with knee injuries was significantly higher in engineers than artillery (p < 0.0001), and number of days for low back injuries was significantly higher in the artillerymen (p < 0.0001). Greater body mass was a risk factor for lower back pain and the body mass index was greater than or equal to25 for strains/sprains in both units. Conclusions: Significant differences in injuries were reported between the two units. It is plausible that the differences were related to the diverse training exposures of the units. However, it is beyond the scope of this study to make conclusions about the causes of the injury differences. The data also indicate that body mass and body mass index were identified as modifiable injury risk factors for both units, which suggests that these injuries are preventable. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. Springfield Coll, Dept Hlth Sci, Springfield, MA 01109 USA. RP Reynolds, K (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St, Natick, MA 01760 USA. NR 31 TC 19 Z9 22 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2002 VL 167 IS 12 BP 971 EP 977 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 653EF UT WOS:000181421700003 PM 12502169 ER PT J AU Malone, RD Benedek, DM Carr, RG AF Malone, RD Benedek, DM Carr, RG TI Occupational psychiatry services in a military setting SO MILITARY MEDICINE LA English DT Article AB Occupational psychiatry services have become increasingly important since the passage of the Americans with Disabilities Act and the recent growth of workers' compensation mental health claims. Delivery of such services within the military is complicated by interagency financial relationships, recent implementation of a comprehensive managed care program, and military regulations governing medical services. In this article, we describe the provision of occupational psychiatry services in a large military medical system and present the results of a feasibility study of establishing a regular clinic to improve them. The results of the study highlighted the importance of having occupational psychiatry services available within the medical center, although it did not establish the necessity of a specific clinic to provide these services. Case material is presented that illustrates our approach and the range of services encompassed. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Malone, RD (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2002 VL 167 IS 12 BP 982 EP 985 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 653EF UT WOS:000181421700005 PM 12502171 ER PT J AU Robert, L Yelton, J AF Robert, L Yelton, J TI Imported furuncular myiasis in Germany SO MILITARY MEDICINE LA English DT Article ID DERMATOBIA-HOMINIS AB Furuncular myiasis is a parasitic infestation of human and other vertebrate tissues by fly larvae of primarily two species: Dermatobia hominis (human botfly, torsalo, or berne) in Mexico and South and Central America and Cordylobia anthropophaga (tumbu fly or mango fly) in Africa. Cuterebra species (rabbit and rodent botflies) are also rarely reported to cause furuncular myiasis only within the United States. Although these species inhabit different geographic regions and have different life cycles, their clinical presentations can be similar. We describe a case of "imported" human botfly (D. hominis) furuncular myiasis in a U.S. Army soldier stationed in Germany. We review the life cycles of human botflies and key aspects of their clinical presentation, differential diagnosis, and various therapeutic modalities. Most physicians may never encounter myiasis and attribute a patient's complaints to an insect bite or skin infection that will heal without treatment. However, the diagnosis of furuncular myiasis should be considered by remembering the basic elements of this condition: recent travel history to the tropics and a sterile, persistent furuncle with sensations of movement and pain. C1 Ctr Hlth Promot & Prevent Med Europe, Dept Environm Sci, APO, AE 09180 USA. USA, Hlth Clin, APO, AE 09252 USA. RP Robert, L (reprint author), Ctr Hlth Promot & Prevent Med Europe, Dept Environm Sci, APO, AE 09180 USA. NR 17 TC 8 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2002 VL 167 IS 12 BP 990 EP 993 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 653EF UT WOS:000181421700007 PM 12502173 ER PT J AU Friedl, KE Leu, JR AF Friedl, KE Leu, JR TI Body fat standards and individual physical readiness in a randomized army sample: Screening weights, methods of fat assessment, and linkage to physical fitness SO MILITARY MEDICINE LA English DT Article ID MASS INDEX; PREVALENCE; WOMEN AB Body fat standards have been used by the military services since the early 1980s to prevent obesity and motivate good fitness habits. The Army Weight Control Program has continued to undergo evaluation and incorporate improvements based on emerging scientific findings. Recently drafted revisions of Department of Defense-wide procedures address issues of consistency and validity raised by external oversight groups. This study evaluated the impact of three proposed refinements of the Army Weight Control Program. Anthropometric measurements and fitness test I performance were obtained in a randomized sample of 1,038 male and 347 nonpregnant female soldiers at three Army posts. Of this sample, 11% of men and 17% of women were overweight and overfat; 6.3 and 9.8%, respectively, were currently on the Army Weight Control Program. Screening weight tables that ensure women are not inappropriately striving to meet weights more stringent than "healthy" weight (i.e., body mass index < 25 kg/m(2)) still correctly identified all women for evaluation for the age-specific body fat standards. Body fat estimation using more valid DoD body fat equations that include an abdominal circumference for women reduced the number of female soldiers currently classified as exceeding fat standards, coincidentally resulting in a comparable prevalence of male and female soldiers over the fat standards (12%). A body fat allowance for young soldiers who scored very well on the physical fitness test could have benefited one-fourth of the soldiers exceeding fat standards and acknowledges biological variability in body fat thresholds. Whereas this linkage may motivate fitness habits, it complicates enforcement of reasonably achievable body fat standards. The proposed changes in fat screening and measurement methods are appropriate, but the impact to health and physical readiness of the Force cannot be accurately predicted or measured because of the absence of comprehensive baseline data and tracking mechanisms. C1 USA, Med Res & Mat Command, Mil Operat Med Res Program, Frederick, MD 21702 USA. USA, Environm Med Res Inst, Ft Bragg Off, Natick, MA 01760 USA. RP Friedl, KE (reprint author), POB 1779, Frederick, MD 21702 USA. OI Friedl, Karl/0000-0002-3134-8427 NR 23 TC 11 Z9 12 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2002 VL 167 IS 12 BP 994 EP 1000 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 653EF UT WOS:000181421700008 PM 12502174 ER PT J AU Potter, RN Gardner, JW Deuster, PA Jenkins, P McKee, K Jones, BH AF Potter, RN Gardner, JW Deuster, PA Jenkins, P McKee, K Jones, BH TI Musculoskeletal injuries in an army Airborne population SO MILITARY MEDICINE LA English DT Article ID STRESS-FRACTURES; OVERUSE INJURIES; PARACHUTING INJURIES; CIGARETTE-SMOKING; MILITARY RECRUITS; INFANTRY SOLDIERS; PHYSICAL-FITNESS; NORTH-CAROLINA; FORT-BRAGG; YOUNG MEN AB To maintain operational readiness, military personnel engage in vigorous physical and training activities that carry risk for injury. A 1-year prospective cohort study, starting April 1996, was conducted at Fort Bragg, North Carolina among 1,965 members of the 82nd Airborne Division to quantify musculoskeletal injuries. Information collected included type of injury, site, circumstances, and resultant limited duty days. These soldiers suffered 508 overuse injuries (including 38 stress fractures), 1,415 traumatic injuries (including 100 fractures), and 101 unclassified injuries. Injury rates were 6.8% per soldier per month for traumatic injury and 2.4% for overuse injury (totaling 1.2 injuries per soldier per year). Injuries resulted in 22,041 limited duty days, averaging 11 days per injury and 13 days per soldier (4.5% of total workdays). Fractures and stress fractures/reactions produced the most days lost per case. Most of these injuries resulted from military-specific activities. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. Womack Army Med Ctr, Ft Bragg, NC USA. Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30338 USA. RP Potter, RN (reprint author), 19525 Transhire Rd, Gaithersburg, MD 20886 USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 36 TC 12 Z9 13 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2002 VL 167 IS 12 BP 1033 EP 1040 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 653EF UT WOS:000181421700015 PM 12502180 ER PT J AU Kuprash, DV Alimzhanov, MB Tumanov, AV Grivennikov, SI Shakhov, AN Drutskaya, LN Marino, MW Turetskaya, RL Anderson, AO Rajewsky, K Pfeffer, M Nedospasov, SA AF Kuprash, DV Alimzhanov, MB Tumanov, AV Grivennikov, SI Shakhov, AN Drutskaya, LN Marino, MW Turetskaya, RL Anderson, AO Rajewsky, K Pfeffer, M Nedospasov, SA TI Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: Mice with inactivation of the entire TNF/LT locus versus single-knockout mice SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID PERIPHERAL LYMPHOID ORGANS; ALPHA-DEFICIENT MICE; NATURAL-KILLER-CELLS; T-CELL; B-CELL; SALMONELLA-TYPHIMURIUM; DENDRITIC CELLS; IMMUNE RESPONSIVENESS; ABNORMAL-DEVELOPMENT; SCAVENGER RECEPTORS AB Homologous genes and gene products often have redundant physiological functions. Members of the tumor necrosis factor (TNF) family of cytokines can signal activation, proliferation, differentiation, costimulation, inhibition, or cell death, depending on the type and status of the target cell. TNF, lymphotoxin alpha (LTalpha), and LTbeta form a subfamily of a larger family of TNF-related ligands with their genes being linked within a compact 12-kb cluster inside the major histocompatibility complex locus. Singly TNF-, LTalpha-, and LTbeta-deficient mice share several phenotypic features, suggesting that TNF/LT signaling pathways may regulate overlapping sets of target genes. In order to directly address the issue of redundancy of TNF/LT signaling, we used the Cre-loxP recombination system to create mice with a deletion of the entire TNF/LT locus. Mice with a triple LTO/TNF/LTalpha deficiency essentially manifest a combination of LT and TNF single-knockout phenotypes, except for microarchitecture of the spleen, where the disorder of lymphoid cell positioning and functional T- and B-cell compartmentalization is severer than that found in TNF or LT single-knockout mice. Thus, our data support the notion that TNF and LT have largely nonredundant functions in vivo. C1 Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 319991, Russia. Moscow MV Lomonosov State Univ, Belozersky Inst Physico Chem Biol, Moscow, Russia. SAIC Frederick Inc, Basic Res Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA. Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany. Univ Cologne, Inst Genet, D-50931 Cologne, Germany. Mem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10021 USA. USA, Med Res Inst Infect Dis, Dept Clin Pathol, Frederick, MD 21702 USA. RP Nedospasov, SA (reprint author), Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, 32 Vavilov St, Moscow 319991, Russia. RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015; Kuprash, Dmitry/O-4899-2015; Nedospasov, Sergei/Q-7319-2016; OI Kuprash, Dmitry/0000-0002-1488-4148; Pfeffer, Klaus/0000-0002-5652-6330 FU NCI NIH HHS [N01CO12400, N01-CO-12400] NR 70 TC 47 Z9 49 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD DEC PY 2002 VL 22 IS 24 BP 8626 EP 8634 DI 10.1128/MCB.22.24.8626-8634.2002 PG 9 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 620HF UT WOS:000179527400023 PM 12446781 ER PT J AU Landau, ME Diaz, MI Barner, KC Campbell, WW AF Landau, ME Diaz, MI Barner, KC Campbell, WW TI Changes in nerve conduction velocity across the elbow due to experimental error SO MUSCLE & NERVE LA English DT Article DE electrodiagnosis; entrapment neuropathy; neural conduction; neurophysiology; ulnar neuropathy ID ABNORMALITIES; LOCALIZATION AB One diagnostic criterion for ulnar nerve mononeuropathy at the elbow (UNE) is a decrease in across-elbow nerve conduction velocity (NCV) > 10 m/s compared to the forearm segment. Distance and latency measurement errors are an inherent part of NCV calculations. Twenty electromyographers measured the latencies of stored ulnar compound muscle action potentials and measured the forearm and across-elbow distances along the ulnar nerve. Based on previously published equations, experimental error in NCV was calculated for various NCVs. The mean distances and standard deviations for the forearm and elbow segments were 212.5 +/- 2.1 mm and 86.7 +/- 4.2 mm, respectively. For an NCV of 55 m/s, a difference of 14 m/s between the two segments can occur from measurement error alone. Distance measurements about the elbow are fraught with interobserver errors rendering the resultant NCV of that segment of limited value as a sole criterion for the diagnosis of UNE. (C) 2002 Wiley Periodicals, Inc. C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Landau, ME (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave, Washington, DC 20307 USA. OI Cardiel, Myrna/0000-0002-4515-5036 NR 5 TC 26 Z9 26 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD DEC PY 2002 VL 26 IS 6 BP 838 EP 840 DI 10.1002/mus.10259 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 621BF UT WOS:000179568100014 PM 12451611 ER PT J AU Barkdoll, TC Gaver, DP Glazebrook, KD Jacobs, PA Posadas, S AF Barkdoll, TC Gaver, DP Glazebrook, KD Jacobs, PA Posadas, S TI Suppression of enemy air defenses (SEAD) as an information duel SO NAVAL RESEARCH LOGISTICS LA English DT Article AB Blue strike aircraft enter region R to attack Red targets. In Case 1, Blue conducts (preplanned) SEAD to establish air superiority. In the (reactive) SEAD scenario, which is Case 2, such superiority is already in place, but is jeopardized by prohibitive interference from Red, which threatens Blue's ability to conduct missions. We utilize both deterministic and stochastic models to explore optimal tactics for Red in such engagements. Policies are developed which will guide both Red's determination of the modes of operation of his engagement radar, and his choice of Blue opponent to target next. An index in the form of a simple transaction kill ratio plays a major role throughout. (C) 2002 Wiley Periodicals, Inc. C1 USN, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA. Univ Edinburgh, Dept Business Studies, Edinburgh EH8 9JY, Midlothian, Scotland. USA, TRADOC Anal Ctr, White Sands Missile Range, NM 88002 USA. RP Gaver, DP (reprint author), USN, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA. NR 13 TC 6 Z9 7 U1 0 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD DEC PY 2002 VL 49 IS 8 BP 723 EP 742 DI 10.1002/nav.10046 PG 20 WC Operations Research & Management Science SC Operations Research & Management Science GA 620EV UT WOS:000179521800001 ER PT J AU Durlach, PJ Edmunds, R Howard, L Tipper, SP AF Durlach, PJ Edmunds, R Howard, L Tipper, SP TI A rapid effect of caffeinated beverages on two choice reaction time tasks SO NUTRITIONAL NEUROSCIENCE LA English DT Article DE caffeine; CANTAB; delay distracter; human; tea ID COGNITIVE PERFORMANCE; RESPONSES; STIMULI; MOOD; REINFORCEMENT; ABSTINENCE; PLACEBO; COFFEE AB Though consumers of tea and coffee can report feeling beneficial subjective effects of consumption virtually immediately, tests for objective effects of caffeine immediately post-consumption have been rare. Two experiments examined caffeine's ability to influence reaction time in choice reaction time tasks, using a dose of caffeine typical of a cup of tea or instant coffee, and testing at short post-consumption delays. Two groups of participants were given 60 mg of caffeine, after overnight abstinence, either in a hot tea drink, or a hot water drink. Two control groups also received hot tea or water, but without caffeine. In Experiment 1. participants were given a keypress task before the drink (baseline), immediately after the drink, and 40 min after the drink. In Experiment 2, a touch-screen test was given either 1. 14, or 27 min post consumption. Caffeine was found to reduce the effect of a distracter on reaction time in the keypress test and to reduce reaction time in a component of the touch-screen task; however, in neither experiment were these effects significantly modulated by post-consumption delay length. Thus, the speed of caffeine's action on psychomotor performance was shown to be on the order of minutes. C1 Army Res Inst, Simulator Syst Res Unit, Orlando, FL 32826 USA. Open Univ, Fac Social Sci Psychol, Milton Keynes MK7 6AA, Bucks, England. Univ Wales, Dept Psychol, Bangor LL57 2AS, Gwynedd, Wales. RP Durlach, PJ (reprint author), Army Res Inst, Simulator Syst Res Unit, 12350 Res Pkwy, Orlando, FL 32826 USA. RI Tipper, Steven/I-6884-2012; OI Tipper, Steven/0000-0002-1554-0531; Tipper, Steven Paul/0000-0002-7066-1117 NR 29 TC 18 Z9 19 U1 0 U2 15 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK,, ABINGDON OX14 4RN, OXON, ENGLAND SN 1028-415X J9 NUTR NEUROSCI JI Nutr. Neurosci. PD DEC PY 2002 VL 5 IS 6 BP 433 EP 442 DI 10.1080/1028415021000039211 PG 10 WC Neurosciences; Nutrition & Dietetics SC Neurosciences & Neurology; Nutrition & Dietetics GA 627BH UT WOS:000179907900008 PM 12509073 ER PT J AU Wilkinson, NW Gustafson, RJ Frizzi, JND AF Wilkinson, NW Gustafson, RJ Frizzi, JND TI The effect of erythromycin on bile excretion and proximal small bowel motility following divided gastric bypass surgery: A prospective randomized placebo-control led trial SO OBESITY SURGERY LA English DT Article DE erythromycin; prokinetic agent; motilin; HIDA scan; small bowel motility; postoperative ileus; gastric bypass; morbid obesity ID IMPROVES GASTROINTESTINAL MOTILITY; POSTOPERATIVE ILEUS; ORAL ERYTHROMYCIN; INTRAVENOUS ERYTHROMYCIN; TOTAL GASTRECTOMY; TRANSIT; CANCER AB Background: No conclusive data exists supporting the use of any prokinetic agent in the postoperative setting. The study was designed to examine the effect of erythromycin on small bowel motility in a placebo-controlled trial of post gastric bypass patients utilizing a standardized nuclear medicine test. Methods: A consecutive series of 21 patients undergoing elective gastric bypass surgery for morbid obesity between September 1999 and March 2001 were enrolled in this prospective double-blind randomized controlled trial. Standard open, divided gastric bypass was performed. Patients were randomized to receive either erythromycin 250 mg I.V. (11 patients) or placebo (10 patients) every 8 hours. On postoperative day 2, a hepatic iminodiacetic acid (HIDA) scan was obtained. Tracer movement through the biliary tree and proximal small bowel was quantified and compared. Results: Tracer clearance from the liver and biliary tree was no different between groups from time of injection through 1 hour. Tracer material clearance from the duodenum into the jejunum was no different between the erythromycin and control groups at 1 hour, 37%+/-13% and 37%+/-22% respectively (P=0.95). At 4 hours, clearance was greater in the erythromycin group, 77%+/-6%, compared to control, 60%+/-20% (P=0.036). The rate of tracer change between hour 1 and 4 (slope) was steeper in the erythromycin group (P=0.048). Conclusions: Erythromycin increases intestinal transit in the postoperative setting. C1 Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. RP Wilkinson, NW (reprint author), Roswell Pk Canc Inst, Elm & Carlton St, Buffalo, NY 14263 USA. NR 19 TC 8 Z9 8 U1 0 U2 1 PU F D-COMMUNICATIONS INC PI TORONTO PA 3100 BAYVIEW AVE, UNIT 4, TORONTO, ONTARIO M2N 5L3, CANADA SN 0960-8923 J9 OBES SURG JI Obes. Surg. PD DEC PY 2002 VL 12 IS 6 BP 765 EP 772 DI 10.1381/096089202320995538 PG 8 WC Surgery SC Surgery GA 637HL UT WOS:000180505600009 PM 12568180 ER PT J AU Gu, ZH Fuks, IM Ciftan, M AF Gu, ZH Fuks, IM Ciftan, M TI Enhanced backscattering at grazing angles SO OPTICS LETTERS LA English DT Article ID PLANE-LAYERED MEDIUM; WAVE DIFFRACTION; ROUGH; LIGHT AB Backscattering signals at small grazing angles are important for space vehicle atmospheric reentrance and subsurface radar sensing applications. They are also useful in Fourier-transform infrared grazing-angle microscopy. Recently we performed an experimental study of far-field scattering at small grazing angles, in particular, of enhanced backscattering at grazing angles. For a randomly weak rough dielectric film upon a reflecting metal substrate, a large enhanced backscattering peak was measured. Experimental results are compared with small perturbation theoretical predictions. (C) 2002 Optical Society of America. C1 Surface Opt Corp, San Diego, CA 92127 USA. Zel Technol, Boulder, CO 80305 USA. NOAA, Environm Technol Lab, Boulder, CO 80305 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gu, ZH (reprint author), Surface Opt Corp, 11555 Rancho Bernardo Rd, San Diego, CA 92127 USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD DEC 1 PY 2002 VL 27 IS 23 BP 2067 EP 2069 DI 10.1364/OL.27.002067 PG 3 WC Optics SC Optics GA 621AC UT WOS:000179565500003 PM 18033443 ER PT J AU Holtel, MR Burgess, LPA AF Holtel, MR Burgess, LPA TI Telemedicine in otolaryngology SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID TELECONSULTATION AB After a series of demonstration projects, otolaryngology has begun to demonstrate clinical efficacy for telemedicine and is showing sustainability. Filling a need is the single most important factor in determining success, and those areas with the most need (eg, areas of geographic or social isolation) have been most successful. Recent legislation has improved reimbursement, while other legislation has added increased security requirements for the transmission of patient information. Equipment and transmission costs have dropped dramatically, but cost effectiveness has generally been demonstrated only when patient transportation or time away from work is calculated. Telemedicine programs that have adopted the principles of successful business models have had the greatest success. C1 USN, Tripler Army Med Ctr, Honolulu, HI 96859 USA. Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA. RP Holtel, MR (reprint author), USN, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 24 TC 6 Z9 6 U1 1 U2 4 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2002 VL 35 IS 6 BP 1263 EP + AR PII S0030-6665(02)00095-6 DI 10.1016/S0030-6665(02)00095-6 PG 21 WC Otorhinolaryngology SC Otorhinolaryngology GA 646UG UT WOS:000181053000012 PM 12687742 ER PT J AU Rizvi, SA Nasrabadi, NM AF Rizvi, SA Nasrabadi, NM TI A modular clutter rejection technique for FLIR imagery using region-based principal component analysis SO PATTERN RECOGNITION LA English DT Article DE automatic target recognition; clutter-rejection; principal component analysis; learning vector quantization ID MULTIPLE AB A modular clutter-rejection technique that uses region-based principal component analysis (PCA) is proposed. A major problem in FLIR ATR is the poorly centered targets generated by the preprocessing stage. Our modular clutter-rejection system uses static as well as dynamic region of interest (ROI) extraction to overcome the problem of poorly centered targets. In static ROI extraction, the center of the representative ROI coincides with the center of the potential target image. In dynamic ROI extraction, a representative ROI is moved in several directions with respect to the center of the potential target image to extract a number of ROIs. Each module in the proposed system applies region-based PCA to generate the feature vectors, which are subsequently used to make a decision about the identity of the potential target. Region-based PCA uses topological features of the targets to reject false alarms. In this technique, a potential target is divided into several regions and a PCA is performed on each region to extract regional feature vectors. We propose using regional feature vectors of arbitrary shapes and dimensions that are optimized for the topology of a target in a particular region. These regional feature vectors are then used by a two-class classifier based on the learning vector quantization to decide whether a potential target is a false alarm or a real target. We also present experimental results using real-life data to evaluate and compare the performance of the clutter-rejection systems with static and dynamic ROI extraction. Published by Elsevier Science Ltd on behalf of Pattern Recognition Society. C1 CUNY Coll Staten Isl, Dept Engn Sci & Phys, Staten Isl, NY 10314 USA. USA, Res Lab, Dept Army, AMSRL,ATTN, Adelphi, MD 20783 USA. RP Rizvi, SA (reprint author), CUNY Coll Staten Isl, Dept Engn Sci & Phys, 2800 Victory Blvd, Staten Isl, NY 10314 USA. NR 6 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD DEC PY 2002 VL 35 IS 12 BP 2895 EP 2904 AR PII S0031-3203(01)00221-7 DI 10.1016/S0031-3203(01)00221-7 PG 10 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 606UE UT WOS:000178751600022 ER PT J AU O'Brien, MM Creamer, KM Hill, EE Welham, J AF O'Brien, MM Creamer, KM Hill, EE Welham, J TI Tolerance of family presence during pediatric cardiopulmonary resuscitation: a snapshot of military and civilian pediatricians, nurses, and residents SO PEDIATRIC EMERGENCY CARE LA English DT Article DE cardiopulmonary resuscitation; family presence ID INVASIVE PROCEDURES; PARENTS WANT; EMERGENCY AB Background: Family presence during cardiopulmonary resuscitation is becoming a more common and accepted practice. Objectives: We wanted to determine the views held by pediatricians on family presence during pediatric cardiopulmonary resuscitation. We hypothesized that physicians who had more experience with critical illness and death would be more willing to allow parental presence. Additionally, we hypothesized that recently trained physicians, who may have had more educational exposure to family presence, would be more open to the practice than physicians who had been practicing longer. Methods: A 10-question survey was distributed to attendees of the American Academy of Pediatrics annual Uniformed Services Pediatric Seminar meeting, as well as pediatric staff and residents at both Tripler Army Medical Center and Kapiolani Women's and Children's Medical Center, Honolulu, Hawaii. Responses were compared using chi(2) analysis, with significance indicated by a P value < 0.05. Results: Of the 245 respondents, 65% indicated that they would not allow parental presence. There was no significant difference in the responses based on gender, military affiliation, or years of experience. Those involved in inpatient-oriented specialties and residents were significantly more likely to allow parental presence during resuscitation than respondents involved in outpatient-oriented specialties (57.5%, 50%, and 26.4%, respectively; P < 0.01). Although only one third of respondents had been involved in a resuscitation during which parents were allowed to be present, the majority (63%) indicated that they would be willing to repeat the practice. Conclusions: Although in the minority, one third of the pediatricians surveyed are comfortable allowing parental presence during cardiopulmonary resuscitation. We conclude that pediatricians who have more frequent contact with seriously ill children are more likely to accept parental presence. Additionally, the exposure to parental presence during resuscitation efforts increases the likelihood of allowing parental presence in future resuscitation efforts. C1 Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP O'Brien, MM (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 12 TC 31 Z9 32 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD DEC PY 2002 VL 18 IS 6 BP 409 EP 413 DI 10.1097/00006565-200212000-00002 PG 5 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 626CM UT WOS:000179854800002 PM 12488832 ER PT J AU McCarthy, J Rabinowitz, D Habib, M Goldman, H Miley, D Stefanyshyn, HY Freeman, S Murray, T Clauselle, R AF McCarthy, J Rabinowitz, D Habib, M Goldman, H Miley, D Stefanyshyn, HY Freeman, S Murray, T Clauselle, R TI Bender Gestalt Recall as a measure of short-term visual memory in children and adolescents with psychotic and other severe disorders SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article AB To investigate the short-term visual memory ability of children and adolescents with severe psychiatric disorders, 82 child and adolescent inpatients and day hospital patients in a state psychiatric hospital were administered the Bender Gestalt Test as part of a psychological assessment and then asked to reproduce the designs from memory. No significant differences were found between groups on either the Bender Gestalt Recall, or the WISC-III IQs and the Digit Span and Symbol Search subtests for Psychotic Disorders (Schizophrenia, Schizoaffective Disorder, Psychosis Not Otherwise Specified), Attention Deficit Hyperactivity Disorder, Mood Disorders or Mood Disorders with co-morbid Attention Deficit Hyperactivity Disorder. The Coding subtest scores of the Psychotic Disorders group were significantly lower than the ADHD group. Analyses showed that the Bender Gestalt Recall was significantly related to age, Performance IQ, and sex. The results were discussed in terms of both the poor cognitive functioning of children and adolescents with persistent, severe mental illness, and the importance of developmental level when using the Bender Gestalt Recall as a rough measure of short-term visual memory. C1 Queens Childrens Psychiat Ctr, Bellerose, NY 11426 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Yeshiva Univ, New York, NY 10033 USA. Columbia Univ, Med Ctr, New York, NY USA. N Shore Univ Hosp, Manhasset, NY USA. RP McCarthy, J (reprint author), Queens Childrens Psychiat Ctr, 74-03 Commonwealth Blvd, Bellerose, NY 11426 USA. NR 16 TC 1 Z9 3 U1 0 U2 3 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD DEC PY 2002 VL 95 IS 3 BP 1233 EP 1238 DI 10.2466/PMS.95.8.1233-1238 PN 2 PG 6 WC Psychology, Experimental SC Psychology GA 639ZB UT WOS:000180659500021 PM 12578264 ER PT J AU Wraback, M Shen, H Rudin, S Bellotti, E AF Wraback, M Shen, H Rudin, S Bellotti, E TI Experimental and theoretical studies of transient electron velocity overshoot in GaN SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS LA English DT Article; Proceedings Paper CT International Workshop on Nitride Semiconductors (IWN 2002) CY JUL 22-25, 2002 CL AACHEN, GERMANY SP Res Ctr Julich, AIXTRON, Deutsch Forsch Gemeinsch, European Off Aerosp Res & Dev, Deutsch Gesell Kristallwachstum & Kristallzucht ID RESOLVED ELECTROABSORPTION MEASUREMENT; NITRIDE; SEMICONDUCTORS; TRANSPORT; INN; ALN AB We employ an optically detected time-of-flight technique with femtosecond resolution that monitors the change in the electroabsorption due to charge transport in an AlGaN/GaN heterojunction p-i-n diode to measure the electron velocity overshoot in GaN at room temperature. It has been found that electron velocity overshoot occurs at electric fields as low as 105 kV/cm, with the peak transient velocity increasing with E up to similar to320 kV/cm. at which field a peak velocity of 7.25 x 10(7) cm/s is attained within the first 200 fs after photoexcitation. At higher fields, the increase in transit time with increasing field suggests the onset of negative differential resistance due to intervalley transfer. The existence of transient velocity overshoot at fields lower than the calculated peak steady-state velocity suggests that it occurs while the electron, are primarily in the Gamma valley. Full zone Monte Carlo calculations imply that the overshoot is associated more with band nonparabolicity in the Gamma valley than with intervalley transfer at fields less than 325 kV/cm, and, in conjunction with theoretical calculations employing a semiclassical transport model, confirm the importance of this nonparabolicity for the determination of the temporal shape of the transient velocity overshoot curves. C1 USA, Res Lab, Sensors & Electron Devices Directorate, AMSRL SE EM, Adelphi, MD 20783 USA. Boston Univ, Elect & Comp Engn Dept, Boston, MA 02215 USA. RP Shen, H (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pshen@arl.armY.MIL NR 14 TC 2 Z9 2 U1 0 U2 3 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0370-1972 EI 1521-3951 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Solid State Phys. PD DEC PY 2002 VL 234 IS 3 BP 810 EP 816 DI 10.1002/1521-3951(200212)234:3<810::AID-PSSB810>3.0.CO;2-W PG 7 WC Physics, Condensed Matter SC Physics GA 629EV UT WOS:000180038200027 ER PT J AU Blank, S AF Blank, S TI After the breakup of a multi-ethnic empire: Russia, successor states, and Eurasian security SO POLITICAL SCIENCE QUARTERLY LA English DT Book Review C1 USA, War Coll, Washington, DC 20310 USA. RP Blank, S (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ACAD POLITICAL SCIENCE PI NEW YORK PA 475 RIVERSIDE DRIVE, SUITE 1274, NEW YORK, NY 10115-1274 USA SN 0032-3195 J9 POLIT SCI QUART JI Polit. Sci. Q. PD WIN PY 2002 VL 117 IS 4 BP 702 EP 703 DI 10.2307/798163 PG 2 WC Political Science SC Government & Law GA 637KC UT WOS:000180509400033 ER PT J AU Magill, AJ AF Magill, AJ TI The prevention of malaria SO PRIMARY CARE LA English DT Review ID PLACEBO-CONTROLLED TRIAL; IMPORTED FALCIPARUM-MALARIA; FIELD-EVALUATION; PLASMODIUM-FALCIPARUM; ANOPHELES-ARABIENSIS; ANTIMALARIAL PROPHYLAXIS; MEFLOQUINE PROPHYLAXIS; INTRAVENOUS QUINIDINE; PERSONAL PROTECTION; NONIMMUNE TRAVELERS AB Long before. the advent of modern chemoprophylaxis drugs, many practitioners successfully prevented the debilitating and fatal outcomes associated with infection by the Plasmodium parasites that cause malaria. Today, with effective insect repellents and several excellent medications available for chemoprophylaxis, there has never been a better array of quality products to prevent mosquito bites and infection and to suppress parasites once in the blood stream; however, there are thousands of imported cases into nonendemic countries and scores of deaths and near-fatal outcomes every year in returning travelers, soldiers, immigrants, and refugees. In this article, the author focuses on practical uses of currently available prevention tools. C1 Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. RP Magill, AJ (reprint author), Walter Reed Army Inst Res, Div Communicable Dis & Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 131 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0095-4543 J9 PRIMARY CARE JI Primary Care PD DEC PY 2002 VL 29 IS 4 BP 815 EP + AR PII S0095-4543(02)00042-8 DI 10.1016/S0095-4543(02)00042-8 PG 30 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 628CT UT WOS:000179975300004 PM 12687895 ER PT J AU Zisman, DA Shorr, AF Lynch, JP AF Zisman, DA Shorr, AF Lynch, JP TI Sarcoidosis involving the musculoskeletal system SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Review DE sarcoidosis; muscle; myopathy; bone; osseous; articular; musculoskeletal ID BONE-MINERAL DENSITY; CORTICOSTEROID-INDUCED OSTEOPOROSIS; RESPIRATORY MUSCLE INVOLVEMENT; CULTURED ALVEOLAR MACROPHAGES; MUSCULAR SARCOIDOSIS; PULMONARY SARCOIDOSIS; OSSEOUS SARCOIDOSIS; CALCIUM-METABOLISM; SKELETAL-MUSCLE; GRANULOMATOUS MYOSITIS AB Although sarcoidosis can affect virtually any organ, musculoskeletal involvement is infrequent. Early in the course of the disease, acute polyarthritis may be observed in up to 40% of patients, but this is often self-limited. Chronic or recurrent sarcoid arthritis is rare, affecting only 1 to 4% of patients. Asymptomatic involvement of muscles has been reported in 25 to 75% of patients in small series, but symptomatic involvement of muscles is rare. Although prospective studies assessing the prevalence of muscle involvement in sarcoidosis have not been done, several large retrospective studies suggest that symptomatic muscle involvement occurs in < 0.5% of patients with sarcoidosis. Patterns of sarcoid muscle involvement include chronic, progressive myopathy; nodular or tumorous sarcoidosis affecting muscles; and an acute polymyositis-like syndrome. Corticosteroid therapy is usually efficacious for the acute myositis variant but is less consistently helpful in the other forms (e.g., chronic myopathy or nodules). Similarly, clinically significant involvement of bone is rare (< 2-5%), and is often associated with chronic multisystemic disease, lupus pernio, and chronic uveitis. Unfortunately, osseous sarcoidosis is often unresponsive to therapy. In this review, we discuss the prevalence, clinical features, and management of sarcoidosis involving muscle, joints, and bones. C1 Univ Michigan, Med Ctr, Div Pulm & Crit Care Med, Dept Internal Med, Ann Arbor, MI 48109 USA. Univ Penn, Sch Med, Dept Med, Div Pulm, Philadelphia, PA 19104 USA. Univ Penn, Sch Med, Dept Med, Div Allergy & Crit Care, Philadelphia, PA 19104 USA. Walter Reed Army Med Ctr, Dept Internal Med, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. RP Lynch, JP (reprint author), Univ Michigan, Med Ctr, Div Pulm & Crit Care Med, Dept Internal Med, 3916 Taubman Ctr,Box 0360, Ann Arbor, MI 48109 USA. NR 164 TC 33 Z9 33 U1 0 U2 2 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1069-3424 J9 SEM RESP CRIT CARE M JI Semin. Respir. Crit. Care Med. PD DEC PY 2002 VL 23 IS 6 BP 555 EP 570 DI 10.1055/s-2002-36520 PG 16 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 630QN UT WOS:000180119900007 PM 16088651 ER PT J AU Butler, JC Vigliotti, AJ Verdi, FW Walsh, SM AF Butler, JC Vigliotti, AJ Verdi, FW Walsh, SM TI Wireless, passive, resonant-circuit, inductively coupled, inductive strain sensor SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE inductive coupling; remote query; strain sensor; non-destructive evaluation ID DESIGN AB This paper presents a non-contact, wireless, passive, inductively coupled strain sensor. The sensor itself is a parallel-connected LC tank circuit. Small geometric changes in a stressed solenoidal inductor were predicted to affect its inductance and as a consequence the resonant frequency of the LC circuit. Using a gate dip meter as a sensitive detector, this was experimentally confirmed. There was found to be a consistent relationship between relative strain with shifted resonant frequency independent of whether the sensor was embedded or not. Crown Copyright (C) 2002 Published by Elsevier Science B.V. All rights reserved. C1 Amer Competitiveness Inst, Philadelphia, PA 19113 USA. USA, Res Lab, APG, Aberdeen Proving Ground, MD 21005 USA. RP Butler, JC (reprint author), Amer Competitiveness Inst, 1 Int Plaza,Suite 600, Philadelphia, PA 19113 USA. NR 9 TC 66 Z9 68 U1 2 U2 15 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD DEC 1 PY 2002 VL 102 IS 1-2 BP 61 EP 66 AR PII S0924-4247(02)00342-4 DI 10.1016/S0924-4247(02)00342-4 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 619LZ UT WOS:000179478600009 ER PT J AU Swami, A Sadler, BM AF Swami, A Sadler, BM TI On some detection and estimation problems in heavy-tailed noise SO SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT Conference on Heavy Tailed Distributions in Economics, Engineering, and Statistics CY JUN, 1999 CL WASHINGTON, D.C. DE alpha-stable processes; robust estimation; robust detection; normalized higher-order statistics ID NON-GAUSSIAN NOISE; PARAMETER-ESTIMATION; MAXIMUM-LIKELIHOOD; IDENTIFICATION; INTERFERENCE; STATISTICS; MODELS; ESPRIT; BOUNDS AB We consider the problem of estimating the parameters of a linear process with stable innovations; the linear system may be non-causal and have mixed-phase (i.e., poles and/or zeros may be inside or outside the unit circle). We show that self-normalized fourth-order moments exist, can be consistently estimated, and lead to consistent estimates of the ARMA model parameters. In the context of estimating the parameters of finite variance (or deterministic) signals observed in alpha-stable noise, we show that conventional correlation-based schemes can be used provided that the noisy data have been pre-processed by passing them through a generic zero-memory non-linearity which serves to clip the noise. We demonstrate this through applications to harmonic retrieval and direction of arrival estimation. The idea is also seen to be useful in estimating the underlying correlation matrix of a sub-Gaussian stable process. These pre-processing ideas are also shown to be useful in the context of detection and classification, and to outperform standard approaches. Numerical results related to the Fisher information and Cramer-Rao bounds are also presented. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP USA, Res Lab, Adelphi, MD 20783 USA. EM a.swami@ieee.org; bsadler@arl.army.mil NR 53 TC 30 Z9 33 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-1684 EI 1879-2677 J9 SIGNAL PROCESS JI Signal Process. PD DEC PY 2002 VL 82 IS 12 BP 1829 EP 1846 AR PII S0165-1684(02)00314-6 DI 10.1016/S0165-1684(02)00314-6 PG 18 WC Engineering, Electrical & Electronic SC Engineering GA 614QL UT WOS:000179200800003 ER PT J AU Poli, MA Rivera, VR Neal, D AF Poli, MA Rivera, VR Neal, D TI Sensitive and specific colorimetric ELISAs for Staphylococcus aureus enterotoxins A and B in urine and buffer SO TOXICON LA English DT Article DE Staphylococcal enterotoxins; detection; ELISA ID LINKED-IMMUNOSORBENT-ASSAY; CROSS-REACTIVITY; MONOCLONAL-ANTIBODIES; TOXIN; SUPERANTIGENS; LOCALIZATION; ACTIVATION; FOODS AB We present here simple, sensitive and accurate colorimetric capture ELISAs for staphylococcal enterotoxins A and B. Standard curves were linear over the range 0.5-1 ng/mL, and toxins could be accurately measured at 0.5 ng/mL in assay buffer or 0.1 ng/mL in human urine. Cross-reactivity between serotypes was negligible. Detection in serum was complicated by the presence of specific antibodies to SE's in most normal sera. These assays offer a viable, cost-effective method for analysis of these ubiquitous toxins. Further, their sensitivity in undiluted urine makes them ideal candidates for evaluating human exposure. Published by Elsevier Science Ltd. C1 USA, Med Res Inst Infect Dis, Toxinol & Aerobiol Div, Ft Detrick, MD 21702 USA. Medimmune Inc, Frederick, MD 21703 USA. RP Poli, MA (reprint author), USA, Med Res Inst Infect Dis, Toxinol & Aerobiol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 24 TC 24 Z9 28 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC PY 2002 VL 40 IS 12 BP 1723 EP 1726 AR PII S0041-0101(02)00202-7 DI 10.1016/S0041-0101(02)00202-7 PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 631DN UT WOS:000180152300011 PM 12457885 ER PT J AU Hay, SI Rogers, DJ Randolph, SE Stern, DI Cox, J Shanks, GD Snow, RW AF Hay, SI Rogers, DJ Randolph, SE Stern, DI Cox, J Shanks, GD Snow, RW TI Hot topic or hot air? Climate change and malaria resurgence in East African highlands SO TRENDS IN PARASITOLOGY LA English DT Article ID VECTOR-BORNE DISEASES; PLASMODIUM-FALCIPARUM MALARIA; INFECTIOUS-DISEASES; EL-NINO; CHLOROQUINE; BURUNDI; FUTURE; EPIDEMIC; HEALTH; IMPACT AB Climate has a significant impact on malaria incidence and we have predicted that forecast climate changes might cause some modifications to the present global distribution of malaria close to its present boundaries. However, it is quite another matter to attribute recent resurgences of malaria in the highlands of East Africa to climate change. Analyses of malaria time-series at such sites have shown that malaria incidence has increased in the absence of co-varying changes in climate. We find the widespread increase in resistance of the malaria parasite to drugs and the decrease in vector control activities to be more likely driving forces behind the malaria resurgence. C1 Univ Oxford, Dept Zool, Oxford OX1 3PS, England. Rensselaer Polytech Inst, Dept Econ, Troy, NY 12180 USA. Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England. Armed Forces Res Inst Med Sci, USA, Med Component, Bangkok 10400, Thailand. Kenya Govt Med Res Ctr, Wellcome Trust Collaborat Programme, Nairobi 43640, Kenya. RP Hay, SI (reprint author), Univ Oxford, Dept Zool, S Parks Rd, Oxford OX1 3PS, England. RI Stern, David/B-4700-2009; Hay, Simon/F-8967-2015; Shanks, George Dennis/F-4056-2014 OI Stern, David/0000-0001-6595-4268; Hay, Simon/0000-0002-0611-7272; Shanks, George Dennis/0000-0001-5763-8660 FU Wellcome Trust [056642] NR 53 TC 91 Z9 93 U1 1 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD DEC PY 2002 VL 18 IS 12 BP 530 EP 534 AR PII S1471-4922(02)02374-7 DI 10.1016/S1471-4922(02)02374-7 PG 5 WC Parasitology SC Parasitology GA 618RV UT WOS:000179431800007 PM 12482536 ER PT J AU Blank, SJ AF Blank, SJ TI Putin's twelve-step program SO WASHINGTON QUARTERLY LA English DT Article C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Blank, SJ (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. NR 35 TC 2 Z9 2 U1 0 U2 0 PU M I T PRESS PI CAMBRIDGE PA FIVE CAMBRIDGE CENTER, CAMBRIDGE, MA 02142 USA SN 0163-660X J9 WASH QUART JI Wash. Q. PD WIN PY 2002 VL 25 IS 1 BP 147 EP 160 DI 10.1162/016366002753358384 PG 14 WC International Relations; Law SC International Relations; Government & Law GA 501QC UT WOS:000172696100012 ER PT J AU Rosenberg, Y Luo, CT Ashani, Y Doctor, BP Fischer, R Wolfe, G Saxena, A AF Rosenberg, Y Luo, CT Ashani, Y Doctor, BP Fischer, R Wolfe, G Saxena, A TI Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase SO LIFE SCIENCES LA English DT Article DE cholinesterases; bioscavenger; organophosphate poisoning; immunological consequences; pharmacokinetics ID BOVINE SERUM ACETYLCHOLINESTERASE; RHESUS-MONKEYS; TOXICITY; SOMAN; CHOLINESTERASE; GLYCOPROTEINS; PRETREATMENT; PROTECTION; PURIFICATION; PROPHYLAXIS AB Exposure to organophosphorus compounds (OPs), in the form of nerve agents and pesticides poses an ever increasing military and civilian threat. In recent years, attention has focused on the use of exogenously administered cholinesterases as an effective prophylactic treatment for protection against OPs. Clearly, a critical prerequisite for any potential bioscavenger is a prolonged circulatory residence time, which is influenced by the size of protein, the microheterogeneity of carbohydrate structures, and the induction (if any) of anti-enzyme antibodies following repeated injections of the enzyme. Previously, it was demonstrated that multiple injections of equine butyrylcholinesterase (BChE) into rabbits, rats, or rhesus monkeys, resulted in a mean residence time spanning several days, and variable immune responses. The present study sought to assess the pharmacokinetics and immunological consequences of administration of purified macaque BChE into macaques of the same species at a dose similar to that required for preventing OP toxicity. An i.v. injection of 7,000 U of homologous enzyme in monkeys demonstrated much longer mean residence times in plasma (MRT = 225 +/- 19 h) : compared to those reported for heterologous Hu BChE (33.7 +/- 2.9 h). A smaller second injection of 3,000 U given four weeks later, attained predicted peak plasma levels of enzyme activity, but surprisingly, the MRT in the four macaques showed wide variation and ranged from 54 to 357 h. No antibody response was detected in macaques following either injection of enzyme. These results bode well for the potential use of human BChE as a detoxifying drug in humans. (C) 2002 Elsevier Science Inc. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. ProCell Corp, Rockville, MD 20850 USA. Israel Inst Biol Res, IL-70450 Ness Ziona, Israel. TherImmune Res, Gaithersburg, MD 20878 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. NR 35 TC 20 Z9 21 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD NOV 29 PY 2002 VL 72 IS 2 BP 125 EP 134 AR PII S0024-3205(02)02203-8 DI 10.1016/S0024-3205(02)02203-8 PG 10 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 613KP UT WOS:000179131700002 PM 12417246 ER PT J AU Genton, MG Gorsich, DJ AF Genton, MG Gorsich, DJ TI Nonparametric variogram and covariogram estimation with Fourier-Bessel matrices SO COMPUTATIONAL STATISTICS & DATA ANALYSIS LA English DT Article DE discretization; Fourier-Bessel expansion; kriging; nonnegative least squares; orthogonality; positive definiteness; spatial statistics ID TRANSFORM AB The nonparametric estimation of variograms and covariograms for isotropic stationary spatial stochastic processes is considered. It is shown that Fourier-Bessel matrices play an important role in this context because they provide an orthogonal discretization of the spectral representation of positive definite functions. Their properties are investigated and an example from a simulated two-dimensional spatial process is provided. It is shown that this approach provides a smooth and positive definite nonparametric estimator in the continuum, whereas previous methods typically suffer from spurious oscillations. A practical example from Astronomy is used for illustration. (C) 2002 Elsevier Science B.V. All rights reserved. C1 N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA. USA, TACOM, Natl Automot Ctr, AMSTA TR N,MS 289, Warren, MI 48397 USA. NR 30 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9473 J9 COMPUT STAT DATA AN JI Comput. Stat. Data Anal. PD NOV 28 PY 2002 VL 41 IS 1 BP 47 EP 57 AR PII S0167-9473(02)00062-2 DI 10.1016/S0167-9473(02)00062-2 PG 11 WC Computer Science, Interdisciplinary Applications; Statistics & Probability SC Computer Science; Mathematics GA 615NV UT WOS:000179253400004 ER PT J AU Sundar, S Jha, TK Thakur, CP Engel, J Sindermann, H Fischer, C Junge, K Bryceson, A Berman, J AF Sundar, S Jha, TK Thakur, CP Engel, J Sindermann, H Fischer, C Junge, K Bryceson, A Berman, J TI Oral miltefosine for Indian visceral leishmaniasis SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID AMPHOTERICIN-B; KALA-AZAR; TRIAL; DONOVANI AB Background: There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral. Miltefosine is an oral agent that has been shown in small numbers of patients to have a favorable therapeutic index for Indian visceral leishmaniasis. We performed a clinical trial in India comparing miltefosine with the most effective standard treatment, amphotericin B. Methods: The study was a randomized, open-label comparison, in which 299 patients 12 years of age or older received orally administered miltefosine (50 or 100 mg [approximately 2.5 mg per kilogram of body weight] daily for 28 days) and 99 patients received intravenously administered amphotericin B (1 mg per kilogram every other day for a total of 15 injections). Results: The groups were well matched in terms of age, weight, proportion with previous failure of treatment for leishmaniasis, parasitologic grade of splenic aspirate, and splenomegaly. At the end of treatment, splenic aspirates were obtained from 293 patients in the miltefosine group and 98 patients in the amphotericin B group. No parasites were identified, for an initial cure rate of 100 percent. By six months after the completion of treatment, 282 of the 299 patients in the miltefosine group (94 percent [95 percent confidence interval, 91 to 97]) and 96 of the 99 patients in the amphotericin B group (97 percent) had not had a relapse; these patients were classified as cured. Vomiting and diarrhea, generally lasting one to two days, occurred in 38 percent and 20 percent of the patients in the miltefosine group, respectively. Conclusions: Oral miltefosine is an effective and safe treatment for Indian visceral leishmaniasis. Miltefosine may be particularly advantageous because it can be administered orally. It may also be helpful in regions where parasites are resistant to current agents. C1 Kala Azar Res Ctr, Brahmpura, Muzaffarpur, India. Banaras Hindu Univ, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India. Balaji Utthan Sanastan, Patna, Bihar, India. Zentaris Asta Med, Frankfurt, Germany. London Sch Hyg & Trop Med, London WC1, England. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Berman, J (reprint author), Natl Ctr Complementary & Alternat Med, 6707 Democracy Blvd,Ste 401, Bethesda, MD 20892 USA. NR 20 TC 401 Z9 413 U1 1 U2 7 PU MASSACHUSETTS MEDICAL SOC/NEJM PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 28 PY 2002 VL 347 IS 22 BP 1739 EP 1746 DI 10.1056/NEJMoa021556 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 619GU UT WOS:000179468600003 PM 12456849 ER PT J AU Montgomery, SP Xu, H Tadaki, DK Celniker, A Burkly, LC Berning, JD Cruzata, F Elster, EA Gray, G Kampen, RL Swanson, SJ Harlan, DM Kirk, AD AF Montgomery, SP Xu, H Tadaki, DK Celniker, A Burkly, LC Berning, JD Cruzata, F Elster, EA Gray, G Kampen, RL Swanson, SJ Harlan, DM Kirk, AD TI Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation SO TRANSPLANTATION LA English DT Article ID INTRAHEPATIC ISLET ALLOGRAFTS; DONOR-SPECIFIC TRANSFUSION; LONG-TERM SURVIVAL; HUMANIZED ANTI-CD154; REJECTION; SKIN; ACCEPTANCE; BLOCKING; PATHWAYS; MODEL AB Background. Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing donor-specific tolerance in rodents. These agents have also been shown to be synergistic with one another in many settings of counter-adaptive immunity. In the nonhuman primate, monoclonal antibodies specific for CD80 and CD86 have prolonged the time to rejection of renal allografts but have not resulted in tolerance. A monoclonal antibody specific for CD154 has resulted in markedly prolonged survival of kidney, islet, cardiac, and skin allografts, but again most animals have eventually developed rejection after prolonged periods of rejection-free survival off therapy. Methods. A combination of monoclonal antibodies specific for CD80, CD86, and CD154 were used in a mismatched nonhuman primate renal-allograft model. Doses used were based on optimized treatment protocols for each agent individually. Results. Treatment of four rhesus macaques with this combination yielded a mean rejection-free survival of 565 days (311-911 days), significantly greater than untreated controls (mean survival = 7.0 days, P = 0.001) and animals treated with only a combination of anti-CD80 and CD86 (mean survival = 191 days, P = 0.01). The survival of animals treated with this combination of monoclonal antibodies was not significantly greater than those treated with anti-CD154 alone, but the production of alloantibody was delayed compared with monotherapy anti-CD154. C1 NIDDK, Transplantat & Autoimmun Branch, Bethesda, MD 20889 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Wyeth, Andover, MA USA. Biogen Inc, Cambridge, MA USA. RP Kirk, AD (reprint author), NIDDK, Transplantat & Autoimmun Branch, Room 11-S-219,Bldg 10,Ctr Dr, Bethesda, MD 20889 USA. RI Kirk, Allan/B-6905-2012 FU NIAID NIH HHS [AI43900-01] NR 18 TC 42 Z9 45 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2002 VL 74 IS 10 BP 1365 EP 1369 DI 10.1097/01.TP.0000040001.25099.D3 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 618TG UT WOS:000179432900002 PM 12451232 ER PT J AU Hammersen, E AF Hammersen, E TI The hills are alive with ... SO NATION LA English DT Letter C1 USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATION CO INC PI NEW YORK PA 72 FIFTH AVE, NEW YORK, NY 10011 USA SN 0027-8378 J9 NATION JI Nation PD NOV 25 PY 2002 VL 275 IS 18 BP 2 EP 2 PG 1 WC Political Science SC Government & Law GA 613YC UT WOS:000179158300004 ER PT J AU Walker, D Clark, SM Cranswick, LMD Johnson, MC Jones, RL AF Walker, D Clark, SM Cranswick, LMD Johnson, MC Jones, RL TI O-2 volumes at high pressure from KClO4 decomposition: D '' as a siderophile element pump instead of a lid on the core SO GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS LA English DT Article DE oxygen volume; high-pressure; D ''; core evolution; potassium perchlorate; 1015 geochemistry : composition of the core; 3630 minerology and petrology : experimental minerology and petrology; 3919 mineral physics : equations of the state; 8125 tectonophysics : evolution of the Earth ID EARTHS CORE; POWDER DIFFRACTION; LOWER MANTLE; IRON-METEORITES; ALKALI-HALIDES; MELTING CURVE; FLUID OXYGEN; HIGH-DENSITY; LIQUID-IRON; MOLTEN IRON AB [1] New measurements of the high-pressure volume of oxygen make plausible old, controversial diamond anvil cell (DAC) observations of a high-pressure reaction between liquid Fe and Fe-bearing silicate in which FeO dissolved into liquid Fe. If the Earth's D" layer between core and mantle is the waste product of this reaction proceeding forward with oxygen transfer to the core, then D" would form an effective lid preventing escape of siderophile elements from the core. On the other hand, it is at least as plausible that the core is now oxygen saturated and that core cooling and internal crystallization drive this reaction backward with transfer of Fe- and O- rich material out of the core into D". The Os-186 anomalies in some plume basalts are more consistent with this D" as a siderophile element pump scenario than the D" as-lid scenario. Contributions of siderophile elements to the mantle from the core could assist in balancing the persistently enigmatic budget of these elements. C1 Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA. CLRC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England. LBNL, Adv Light Source, Berkeley, CA 94720 USA. Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England. US Mil Acad, Dept Geog & Environm Engn, W Point, NY 10996 USA. RP Walker, D (reprint author), Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA. NR 55 TC 8 Z9 8 U1 1 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 1525-2027 J9 GEOCHEM GEOPHY GEOSY JI Geochem. Geophys. Geosyst. PD NOV 23 PY 2002 VL 3 AR 1070 DI 10.1029/2001GC000225 PG 26 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 619CM UT WOS:000179456400001 ER PT J AU Swanson, SJ Hale, DA Mannon, RB Kleiner, DE Cendales, LC Chamberlain, CE Polly, SM Harlan, DM Kirk, AD AF Swanson, SJ Hale, DA Mannon, RB Kleiner, DE Cendales, LC Chamberlain, CE Polly, SM Harlan, DM Kirk, AD TI Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy SO LANCET LA English DT Article ID TOLERANCE AB Renal allograft recipients generally need to take several immunosuppressive agents for life. Calcineurin inhibitors and glucocorticosteroids are the mainstays of most regimens but have undesirable chronic effects. We postulated that aggressive T-cell depletion combined with the newer immunosuppressant sirolimus would permit transplantation without multidrug treatment. We therefore tested T-cell depletion with rabbit antithymocyte globulin followed by sirolimus monotherapy in 12 patients in an open-label study. This approach was tolerated well, and all patients achieved excellent renal function, and most did not need chronic steroid treatment or calcineurin inhibitors. Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression. C1 Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. NIDDKD, Transplantat & Autoimmun Branch, NIH, Bethesda, MD 20892 USA. NCI, Dept Pharm, Ctr Clin, NIH, Bethesda, MD 20892 USA. NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. RP Kirk, AD (reprint author), Room 11S-219,Bldg 10,Ctr Dr, Bethesda, MD 20892 USA. RI Kirk, Allan/B-6905-2012; OI Kleiner, David/0000-0003-3442-4453 NR 5 TC 89 Z9 90 U1 0 U2 2 PU LANCET LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0140-6736 J9 LANCET JI Lancet PD NOV 23 PY 2002 VL 360 IS 9346 BP 1662 EP 1664 DI 10.1016/S0140-6736(02)11606-0 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 618AE UT WOS:000179393900014 PM 12457792 ER PT J AU Taylor, AJ AF Taylor, AJ TI Atherosclerosis imaging to detect and monitor cardiovascular risk SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article; Proceedings Paper CT 2nd International Meeting of the Society-of-Atherosclerosis-Imaging CY MAY 31-JUN 02, 2002 CL NEW ORLEANS, LOUISIANA SP Soc Atherosclerosis Imaging ID BEAM COMPUTED-TOMOGRAPHY; INTIMA-MEDIA THICKNESS; CORONARY CALCIUM; MYOCARDIAL-INFARCTION; DISEASE; EVENTS; ADULTS; REPRODUCIBILITY; LESIONS AB Atherosclerosis imaging techniques, such as coronary computed tomography, carotid ultrasound, and vascular magnetic resonance imaging, accurately measure the extent of subclinical atherosclerosis as a biomarker of the effects of an individual patient's coronary risk factors. Among the many potential applications of these tests, their greatest public health impact will be their use in the detection and management of cardiovascular risk. A growing body of data supports the application of these tests for the detection of cardiovascular risk, although further work is needed to document their additive diagnostic and management impact over measured risk factors and the global risk assessment. Each of these tests has a high degree of accuracy and reproducibility creating the potential for serial imaging as a way to monitor cardiovascular risk by the detection of atherosclerosis progression, which is a known marker for an adverse cardiovascular prognosis. (C) 2002 by Excerpta Medica, Inc. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A, Washington, DC 20307 USA. NR 20 TC 11 Z9 11 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD NOV 21 PY 2002 VL 90 IS 10C BP 8L EP 11L AR PII S0002-9149(02)-02954-5 DI 10.1016/S0002-9149(02)02954-5 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 620NK UT WOS:000179539300003 PM 12459419 ER PT J AU Harris, ME Serwadda, D Sewankambo, N Kim, B Kigozi, G Kiwanuka, N Phillips, JB Wabwire, F Meehen, M Lutalo, T Lane, JR Merling, R Gray, R Wawer, M Birx, DL Robb, ML McCutchan, FE AF Harris, ME Serwadda, D Sewankambo, N Kim, B Kigozi, G Kiwanuka, N Phillips, JB Wabwire, F Meehen, M Lutalo, T Lane, JR Merling, R Gray, R Wawer, M Birx, DL Robb, ML McCutchan, FE TI Among 46 near full length HIV type 1 genome sequences from Rakai District, Uganda, subtype D and AD recombinants predominate SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; LONG TERMINAL REPEAT; HETERODUPLEX MOBILITY ASSAY; POLYMERASE-CHAIN-REACTION; VACCINE EVALUATION SITES; PHYLOGENETIC ANALYSIS; GENETIC-CHARACTERIZATION; INTERSUBTYPE RECOMBINANTS; ENVELOPE GLYCOPROTEIN; AFRICAN ORIGIN AB The impact of HIV-1 genetic diversity on candidate vaccines is uncertain. To minimize genetic diversity in the evaluation of HIV-1 vaccines, vaccine products must be matched to the predominant subtype in a vaccine cohort. To that end, full genome sequencing was used to detect and characterize HIV-1 subtypes and recombinant strains from individuals in Rakai District, Uganda. DNA extracted from peripheral blood mononuclear cells (PMBC) was PCR amplified using primers in the long terminal repeats (LTRs) to generate nearly full length genomes. Amplicons were directly sequenced with dye terminators and automated sequencers. Sequences were phylogenetically analyzed and recombinants were detected and mapped with distance scan and bootscan. Among 46 sequences, 54% were subtype D, 15% were subtype A, and 30% were recombinant. All recombinants were individually unique, and most combined subtypes A and D. Subtype D comprised more than 70% of all the HIV-1 genomes in Rakai when both pure subtypes and recombinants were considered. Candidate vaccines based on HIV-1 subtype D would be appropriate for evaluation in Rakai District, Uganda. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Makerere Univ, Kampala, Uganda. Henry M Jackson Fdn, Rockville, MD 20850 USA. Columbia Univ, New York, NY 10032 USA. Uganda Virus Res Inst, Entebbe, Uganda. Johns Hopkins Univ, Baltimore, MD 21205 USA. RP Harris, ME (reprint author), Walter Reed Army Inst Res, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. OI Sewankambo, Nelson/0000-0001-9362-053X NR 74 TC 63 Z9 64 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 20 PY 2002 VL 18 IS 17 BP 1281 EP 1290 DI 10.1089/088922202320886325 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 615CY UT WOS:000179229300005 PM 12487816 ER PT J AU Wright, PF Kozlowski, PA Rybczyk, GK Goepfert, P Staats, HF Vancott, TC Trabattoni, D Sannella, E Mestecky, J AF Wright, PF Kozlowski, PA Rybczyk, GK Goepfert, P Staats, HF Vancott, TC Trabattoni, D Sannella, E Mestecky, J TI Detection of mucosal antibodies in HIV type 1-infected individuals SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT AIDS Vaccine 2001 Conference CY SEP 05-08, 2001 CL PHILADELPHIA, PENNSYLVANIA ID HUMAN-IMMUNODEFICIENCY-VIRUS; GENITAL-TRACT SECRETIONS; INFECTED INDIVIDUALS; SERONEGATIVE PARTNERS; IMMUNE-RESPONSES; IGA ANTIBODIES; SECRETORY IGA; SEX WORKERS; INDUCTION; WOMEN AB HIV-1-specific mucosal IgA antibodies may correlate with protection in highly exposed but uninfected individuals, but have been detected at highly variable levels in HIV-1-infected individuals. To determine the best assays for detection of IgA antibodies in mucosal samples, rectal washes from 16 HIV-1-infected and 14 uninfected individuals were distributed to six laboratories experienced in detection of mucosal antibodies. Assays for HIV-1-specific IgA and IgG were performed in a blinded fashion by each of the laboratories using modifications of ELISA and chemiluminescence-enhanced Western blotting. Rectal washes contained easily detectable total IgA levels that did not differ between HIV-1-infected and uninfected groups. Irrespective of the assay used, HIV-1-specific IgA antibodies were absent in most samples; only one laboratory identified a higher frequency of positive samples from HIV-1-infected than uninfected individuals. In spite of 10-fold lower levels of total IgG than IgA, all but one laboratory identified HIV-1-specific IgG in most rectal washes of HIV-1-infected individuals. Comparable and readily detectable levels of influenza-specific IgA antibodies were present in nasal, salivary, and rectal secretions from both HIV-1-infected and uninfected individuals. These observations suggest a selective alteration in the production of HIV-1-specific IgA antibodies in HIV-1-infected individuals. C1 Vanderbilt Univ, AIDS Vaccine Evaluat Unit, Nashville, TN 37232 USA. Harvard Univ, Sch Med, Childrens Hosp, Dept Med, Boston, MA 02115 USA. Univ Alabama, AIDS Vaccine Evaluat Unit, Birmingham, AL 35284 USA. Duke Univ, Ctr AIDS Res, Durham, NC 27710 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. Henry M Jackson Fdn, Rockville, MD 20850 USA. Univ Milan, Cattedra Immunol, Milan, Italy. Univ Alabama, Mucosal Immunol Lab, Birmingham, AL USA. RP Wright, PF (reprint author), Vanderbilt Univ, AIDS Vaccine Evaluat Unit, Nashville, TN 37232 USA. RI Trabattoni, Daria/G-7424-2012; OI Staats, Herman/0000-0003-1039-1087 FU NCRR NIH HHS [RR0095]; NIAID NIH HHS [AI-28147, N01-AI-45210, N01-AI-85330, R01-AI-48133] NR 37 TC 50 Z9 52 U1 0 U2 3 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 20 PY 2002 VL 18 IS 17 BP 1291 EP 1300 DI 10.1089/088922202320886334 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 615CY UT WOS:000179229300006 PM 12487817 ER PT J AU Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Kucheyev, SO Jagadish, C Williams, JS Wilson, RG Zavada, JM AF Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Kucheyev, SO Jagadish, C Williams, JS Wilson, RG Zavada, JM TI Thermal stability of ion-implanted hydrogen in ZnO SO APPLIED PHYSICS LETTERS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; ZINC-OXIDE; SHALLOW DONOR; THIN-FILMS; SAPPHIRE; DEVICES AB The evolution of implanted H-2 profiles in single-crystal ZnO was examined as a function of annealing temperature (500-700 degreesC) by secondary ion mass spectrometry. The as-implanted profiles show a peak concentration of similar to2.7x10(19) cm(-3) at a depth of similar to0.96 mum for a dose of 10(15) cm(-2). Subsequent annealing causes outdiffusion of H-2 from the ZnO, with the remaining hydrogen decorating the residual implant damage. Only 0.2% of the original dose is retained after annealing at 600 degreesC. Rutherford backscattering/channeling of samples implanted with H-1 at a dose of 10(16) cm(-2) showed no change in backscattering yield near the ZnO surface, but did result in an increase near the end-of-range from 6.5% of the random level before H-1 implantation to similar to7.8% after implantation. Results of both cathodoluminescence and photoluminescence studies show that even for a H-1 dose of 10(15) cm(-2), the intensity of the near gap emission from ZnO is reduced more than 2 orders of magnitude from the values in unimplanted samples. This is due to the formation of effective nonradiative recombination centers associated with ion-beam-induced defects. (C) 2002 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Australian Natl Univ, Res Sch Phys Sci & Engn, Dept Elect Mat Engn, Canberra, ACT 0200, Australia. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Ip, K (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 41 TC 84 Z9 88 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 18 PY 2002 VL 81 IS 21 BP 3996 EP 3998 DI 10.1063/1.1524033 PG 3 WC Physics, Applied SC Physics GA 614TR UT WOS:000179207300028 ER PT J AU Rothwell, SW Chen, WK Krishnamurti, C AF Rothwell, SW Chen, WK Krishnamurti, C TI Gene expression profile of human pulmonary endothelial cells subjected to hypoxic conditions. SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD USA. NHLBI, Div Extramural Affairs, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 3748 BP 69B EP 69B PN 2 PG 1 WC Hematology SC Hematology GA 614JL UT WOS:000179184800291 ER PT J AU Rupard, EJ Greenberg, B Moores, L Roy, M AF Rupard, EJ Greenberg, B Moores, L Roy, M TI Serum calcium is not predictive of ionized calcium SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 4062 BP 144B EP 144B PN 2 PG 1 WC Hematology SC Hematology GA 614JL UT WOS:000179184800605 ER PT J AU Lan, L Jie, Y Levin, L Qin, L Weir, E Mann, RB Borowitz, MJ Mueller, N Mauch, PM Diehl, LF Herman, JG Ambinder, RF AF Lan, L Jie, Y Levin, L Qin, L Weir, E Mann, RB Borowitz, MJ Mueller, N Mauch, PM Diehl, LF Herman, JG Ambinder, RF TI Viral DNA in serum and plasma of patients with Epstein-Barr Virus (EBV)-associated Hodgkin's lymphoma (HL) may be tumor derived and appears years before diagnosis. SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Johns Hopkins Univ, Sch Med, Kimmel Canc Ctr, Baltimore, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Univ Massachusetts, Sch Med, Worcester, MA USA. Harvard Sch Publ Hlth, Boston, MA USA. Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 753 BP 201A EP 201A PN 1 PG 1 WC Hematology SC Hematology GA 614JK UT WOS:000179184700754 ER PT J AU Daniels, JT Perkins, JG Byrd, JC AF Daniels, JT Perkins, JG Byrd, JC TI Rituximab is effective for patients with splenic lymphoma with villous lymphocytes. SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Ohio State Univ, Columbus, OH 43210 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 4793 BP 312B EP 312B PN 2 PG 1 WC Hematology SC Hematology GA 614JL UT WOS:000179184801336 ER PT J AU Gorak, E Waselenko, JK Myhand, RC AF Gorak, E Waselenko, JK Myhand, RC TI Frequent hepatic toxicity in breast cancer patients receiving infusional paclitaxel, cisplatin and cyclophosphamide (PCC) and autologous stem cell transplant (SCT). SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Stem Cell Transplant Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 5304 BP 433B EP 433B PN 2 PG 1 WC Hematology SC Hematology GA 614JL UT WOS:000179184801846 ER PT J AU Myhand, R Mitchell, L Gorak, EJ Waselenko, J Jamison, PB AF Myhand, R Mitchell, L Gorak, EJ Waselenko, J Jamison, PB TI Increased incidence of symptomatic catheter related pulmonary emboli (PE) related to change in catheter brand in patients receiving high dose chemotherapy with stem cell support (HDCT). SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Blood Stem Cell Transplant Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 5312 BP 435B EP 435B PN 2 PG 1 WC Hematology SC Hematology GA 614JL UT WOS:000179184801854 ER PT J AU Waselenko, J Crook, J Murphy, T Myhand, R AF Waselenko, J Crook, J Murphy, T Myhand, R TI Long-term survival in a patient with refractory primary mediastinal non-seminomatous germ cell tumor (MGCT) who failed tandem transplant and was subsequently salvaged with surgery, a third course of high-dose chemotherapy, and mediastinal irradiation. SO BLOOD LA English DT Meeting Abstract CT 44th Annual Meeting of the American-Society-of-Hematology CY DEC 06-10, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Res Inst, Bethesda, MD USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2002 VL 100 IS 11 MA 5504 BP 480B EP 481B PN 2 PG 2 WC Hematology SC Hematology GA 614JL UT WOS:000179184802045 ER PT J AU Doan, NM Keiser, PB Bates, RA Fedorko, DP Weina, PJ Lucey, DR AF Doan, NM Keiser, PB Bates, RA Fedorko, DP Weina, PJ Lucey, DR TI A 33-year-old woman from Nigeria with eosinophilia - Loiasis SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID DOUBLE-BLIND; DIETHYLCARBAMAZINE C1 Washington Hosp Ctr, Washington, DC 20010 USA. NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA. NIH, Microbiol Serv, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Doan, NM (reprint author), Washington Hosp Ctr, Rm 2A-56, Washington, DC 20010 USA. RI Weina, Peter/A-2120-2011 NR 7 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2002 VL 35 IS 10 BP 1204 EP + PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 611PM UT WOS:000179027000009 PM 12420728 ER PT J AU Marvaud, JC Stiles, BG Chenal, A Gillet, D Gibert, M Smith, LA Popoff, MR AF Marvaud, JC Stiles, BG Chenal, A Gillet, D Gibert, M Smith, LA Popoff, MR TI Clostridium perfringens iota toxin - Mapping of the Ia domain involved in docking with Ib and cellular internalization SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID BOTULINUM C2 TOXIN; ADP-RIBOSYLTRANSFERASE ACTIVITY; RIBOSYLATING C3 EXOENZYME; ANTHRAX LETHAL FACTOR; CRYSTAL-STRUCTURE; BINARY TOXIN; PROTECTIVE ANTIGEN; RECEPTOR-BINDING; ESCHERICHIA-COLI; COMPONENT C2II AB Clostridium perfringens iota toxin consists of two unlinked proteins. The binding component (Ib) is required to internalize into cells an enzymatic component (Ia) that ADP-ribosylates G-actin. To characterize the Ia domain that interacts with Ib, fusion proteins were constructed between the C. botulinum C3 enzyme, which ADP-ribosylates Rho, and various truncated versions of Ia. These chimeric molecules retained the wild type ADP-ribosyltransferase activity specific for Rho and were recognized by antibodies against C3 enzyme and Ia. Internalization of each chimera into Vero cells was assessed by measuring the disorganization of the actin cytoskeleton and intracellular ADP-ribosylation of Rho. Fusion proteins containing C3 linked to the C terminus of Ia were transported most efficiently into cells like wild type Ia in an Ib-dependent manner that was blocked by bafilomycin A1. The minimal Ia fragment that promoted translocation of Ia-C3 chimeras into cells consisted of 128 central residues (129-257). These findings revealed that iota toxin is a suitable system for mediating the entry of heterologous proteins such as C3 into cells. C1 Inst Pasteur, CNR Anaerobies, F-75724 Paris 15, France. USA, Med Res Inst Infect Dis, Toxinol Div, Ft Detrick, MD 21702 USA. CEA Saclay, Dept Ingenierie & Etud Prot, F-91191 Gif Sur Yvette, France. RP Popoff, MR (reprint author), Inst Pasteur, CNR Anaerobies, 28 Rue Dr Roux, F-75724 Paris 15, France. NR 52 TC 27 Z9 29 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 15 PY 2002 VL 277 IS 46 BP 43659 EP 43666 DI 10.1074/jbc.M207828200 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 615XE UT WOS:000179272000017 PM 12221101 ER PT J AU Juang, YT Tenbrock, K Nambiar, MP Gourley, MF Tsokos, GC AF Juang, YT Tenbrock, K Nambiar, MP Gourley, MF Tsokos, GC TI Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN T-LYMPHOCYTES; PROTEIN; PROMOTER; CELLS; ENHANCER; ACTIVATION; ELEMENT; GENE; PHOSPHORYLATION; DEGRADATION AB Systemic lupus erythematosus (SLE), the prototypic autoimmune disease, is characterized by defective expression of TCR C-chain. Elf-1 (E-74-like factor) is a member of the Ets (E-26-specific) family and is crucial for the basal transcription of TCR C-chain in Jurkat cells. We previously demonstrated that Elf-1 exists in the cytoplasm mainly as 80-kDa form and after phosphorylation and O-glycosylation it moves to the nucleus as a 98-kDa which binds DNA. We now demonstrate that Elf-1 is crucial for the transactivation of TCR C-chain promoter in normal and SLE T cells. Defective expression of TCR C-chain in SLE T cells is associated with two distinct molecular defects in the generation of the 98-kDa DNA binding Elf-1 form. In the first, the levels of the 98-kDa form were either decreased or absent. In the second, the apparent levels of the nuclear Elf-1 form were normal but included only two of the three bands into which the nuclear Elf-1 form separated in isoelectric focusing gels. Because both the transcription and the translation processes of Elf-1 gene are normal in SLE T cells, our data demonstrate that abnormal posttranslational mechanisms of the Elf-1 protein result in defective expression of functional Elf-1, and consequently, the transcriptional defect of TCR C-chain in patients of SLE. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Washington Hosp Ctr, Dept Med, Washington, DC 20005 USA. RP Juang, YT (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. FU NIAID NIH HHS [R01 AI 49954, R01 AI 42269] NR 29 TC 47 Z9 54 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 2002 VL 169 IS 10 BP 6048 EP 6055 PG 8 WC Immunology SC Immunology GA 614CG UT WOS:000179170300085 PM 12421992 ER PT J AU Burgess, EB AF Burgess, EB TI Collision with history: The search for John F. Kennedy's PT 109. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 15 PY 2002 VL 127 IS 19 BP 83 EP 83 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 615TU UT WOS:000179263500137 ER PT J AU Burgess, EB AF Burgess, EB TI Devil at my heels. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 15 PY 2002 VL 127 IS 19 BP 87 EP 87 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 615TU UT WOS:000179263500158 ER PT J AU Wu, PF Rao, DVGLN Kimball, BR Nakashima, M DeCristofano, BS AF Wu, PF Rao, DVGLN Kimball, BR Nakashima, M DeCristofano, BS TI Enhancement of photoinduced anisotropy and all-optical switching in Bacteriorhodopsin films SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDE STRUCTURES; BIREFRINGENCE; STORAGE AB Large enhancement of photoanisotropic effects is demonstrated in thin films of the biomaterial Bacteriorhodopsin by using two exciting beams of orthogonal polarization. The mechanism of the enhancement originates from optimization of direction-selected photoisomerization of the biomaterial controlled by the polarized exciting beams. The technique is applied for achieving an all-optical switch with the additional feature of output sign control. (C) 2002 American Institute of Physics. C1 Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. USA, Soldier Syst Ctr, Mat Sci Team, Natick, MA 01760 USA. RP Wu, PF (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. RI Rao, Devulapalli/L-8863-2015 NR 19 TC 36 Z9 39 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 11 PY 2002 VL 81 IS 20 BP 3888 EP 3890 DI 10.1063/1.1521581 PG 3 WC Physics, Applied SC Physics GA 611XB UT WOS:000179042200062 ER PT J AU Waisner, S Hansen, L Fredrickson, H Nestler, C Zappi, M Banerji, S Bajpai, R AF Waisner, S Hansen, L Fredrickson, H Nestler, C Zappi, M Banerji, S Bajpai, R TI Biodegradation of RDX within soil-water slurries using a combination of differing redox incubation conditions SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE RDX mineralization; co-metabolism; aerobic biodegradation; radiometry; column studies ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; CONTAMINATED SOIL; BIOLOGICAL DEGRADATION; CHEMICAL-AGENTS; EXPLOSIVES; CARBON AB Biodegradation of C-14-tagged hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was studied in aerobic, anaerobic, and anaerobic/aerobic slurries to identify the conditions maximizing RDX-rnineralization in Cornhusker Army Ammunition Plant (CAAP, NE) groundwater. Supplementation with phosphate and adequate quantities of acetate caused 25% mineralization of RDX in 3 weeks by microorganisms native to CAAP. Under anaerobic conditions, the same supplementation resulted in 20% mineralization in 3 weeks and 30% mineralization in 6 weeks. The highest degree of mineralization (50%) was obtained under aerobic conditions when the contaminated groundwater was augmented with a consortium of three microbes isolated from another RDX contaminated soil (Hastings, NE) in addition to supplemented with phosphate and acetic acid. Use of complex organic sources (potato or corn starch) slowed down the rates of mineralization under anaerobic conditions, but rapid mineralization ensued as soon as the aerobic conditions were created. Final RDX concentrations in aqueous phase were below detection limit under most conditions. Assimilation of RDX by the cells was negligible. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Engineer R&D Ctr, Vicksburg, MS 39180 USA. Mississippi State Univ, Starksville, MS 39762 USA. Univ Missouri, Dept Chem Engn, Columbia, MO 65211 USA. RP Bajpai, R (reprint author), USA, Engineer R&D Ctr, Vicksburg, MS 39180 USA. OI Waisner, Scott/0000-0003-4360-4712 NR 40 TC 13 Z9 13 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV 11 PY 2002 VL 95 IS 1-2 BP 91 EP 106 AR PII S0304-3894(02)00052-3 DI 10.1016/S0304-3894(02)00052-3 PG 16 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 614UW UT WOS:000179210500007 PM 12409241 ER PT J AU Wood, C Salamo, GJ Goff, J Wood, GL Anderson, RJ McGee, DJ AF Wood, C Salamo, GJ Goff, J Wood, GL Anderson, RJ McGee, DJ TI Fixed three-dimensional holographic images SO APPLIED OPTICS LA English DT Article ID PHASE-CONJUGATION; ELECTROOPTIC CRYSTALS; BARIUM-TITANATE; GRATINGS; FIDELITY; DISTORTION; BI12SIO20; BATIO3; KNBO3; MEDIA AB Three-dimensional holograms were recorded in a cerium-doped, strontium barium niobate (SBN:75) photorefractive crystal. These holograms are shown to not degrade after more than one week of continuous readout and to reconstruct reproductions of the original object with an observable field of view of approximately 35degrees. (C) 2002 Optical Society of America. C1 Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA. USA, Res Lab, Adelphi, MD 20783 USA. Natl Sci Fdn, Arlington, VA 22230 USA. Drew Univ, Dept Phys, Madison, NJ 07940 USA. RP Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA. EM salamo@comp.uark.edu NR 27 TC 1 Z9 1 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 10 PY 2002 VL 41 IS 32 BP 6796 EP 6801 DI 10.1364/AO.41.006796 PG 6 WC Optics SC Optics GA 613CA UT WOS:000179112500007 PM 12440533 ER PT J AU Kent, SM Coyle, LC Flaherty, PJ Markwood, TTG Taylor, AJ AF Kent, SM Coyle, LC Flaherty, PJ Markwood, TTG Taylor, AJ TI Carotid atherosclerosis regression is directly related to extent of LDL-C reduction SO CIRCULATION LA English DT Meeting Abstract CT American-Heart-Association Abstracts From Scientific Sessions CY NOV 17-20, 2002 CL CHICAGO, ILLINOIS SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 5 PY 2002 VL 106 IS 19 SU S MA 223 BP 45 EP 45 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 613QJ UT WOS:000179142700265 ER PT J AU Kaul, S Senior, R Firschke, C Wang, XQ Lindner, J Villanueva, F Kontos, M Firoozan, S Taylor, A AF Kaul, S Senior, R Firschke, C Wang, XQ Lindner, J Villanueva, F Kontos, M Firoozan, S Taylor, A TI Myocardial contrast echocardiography in acute coronary syndromes: A multicenter US-Europe study SO CIRCULATION LA English DT Meeting Abstract CT American-Heart-Association Abstracts From Scientific Sessions CY NOV 17-20, 2002 CL CHICAGO, ILLINOIS SP Amer Heart Assoc C1 Univ Virginia, Charlottesville, VA USA. Northwick Pk Hosp & Clin Res Ctr, Harrow HA1 3UJ, Middx, England. Univ Munich, Munich, Germany. Univ Pittsburgh, Pittsburgh, PA USA. Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA. Univ Oxford, Oxford, England. Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 5 PY 2002 VL 106 IS 19 SU S MA 3334 BP 675 EP 676 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 613QJ UT WOS:000179142703372 ER PT J AU O'Malley, PG Feuerstein, I Taylor, A AF O'Malley, PG Feuerstein, I Taylor, A TI Anatomic screening with electron beam tomography does not enhance cardiovascular risk reduction in primary prevention: A randomized, double-blind, controlled trial comparing intensive case management to usual care with or without EBT SO CIRCULATION LA English DT Meeting Abstract CT American-Heart-Association Abstracts From Scientific Sessions CY NOV 17-20, 2002 CL CHICAGO, ILLINOIS SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 5 PY 2002 VL 106 IS 19 SU S MA 3652 BP 743 EP 743 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 613QJ UT WOS:000179142703688 ER PT J AU Ip, K Baik, KH Overberg, ME Lambers, ES Heo, YW Norton, DP Pearton, SJ Ren, F Zavada, JM AF Ip, K Baik, KH Overberg, ME Lambers, ES Heo, YW Norton, DP Pearton, SJ Ren, F Zavada, JM TI Effect of high-density plasma etching on the optical properties and surface stoichiometry of ZnO SO APPLIED PHYSICS LETTERS LA English DT Article ID ROOM-TEMPERATURE; FILMS; SAPPHIRE; CONTACTS; DEVICES; DAMAGE AB Bulk, single-crystal ZnO was etched in Cl-2/Ar and CH4/H-2/Ar inductively coupled plasmas as a function of ion impact energy. For CH4/H-2/Ar, the etch rate (R) increases with ion energy (E) as predicted from a model of ion enhanced sputtering by a collision-cascade process, Rproportional to(E-0.5-E-TH(0.5)), where the threshold energy, E-TH, is similar to96 eV. Band edge photoluminescence intensity decreases with incident ion energy in both chemistries, with a 70% decrease even for low energies (similar to116 eV). Surface roughness is also a function of ion energy with a minimum at similar to250 eV, where Auger electron spectroscopy shows there is no measurable change in near-surface stoichiometry from that of unetched control samples. (C) 2002 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Ip, K (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 33 TC 44 Z9 45 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 4 PY 2002 VL 81 IS 19 BP 3546 EP 3548 DI 10.1063/1.1519095 PG 3 WC Physics, Applied SC Physics GA 609ZA UT WOS:000178935200010 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determinations of tert-butylacetylene SO VIBRATIONAL SPECTROSCOPY LA English DT Article DE tert-butyl acetylene; Hartree-Fock; vibrational frequencies ID TUNGSTEN CARBENE COMPLEX; LIVING POLYMERIZATION; RELAXATION; MOLECULES; CATALYST; ALKYNES; ACID AB The normal mode frequencies and corresponding vibrational assignments of tert-butylacetylene (TBA) are examined theoretically using the Gaussian 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of the nine types of motion (C-C stretch, C=C stretch, C-H stretch, C-C-C bend, C=C-C bend, C=C-H bend, H-C-H bend, CH3 rock, and CH3 twist) utilizing the C-3v symmetry of the molecule. Calculations were performed at the Hartree-Fock, B3LYP, and MP2 levels of theory using the standard 6-311G** basis. Theoretical results were successfully compared against available experimental data. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. NR 42 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-2031 J9 VIB SPECTROSC JI Vib. Spectrosc. PD NOV 4 PY 2002 VL 30 IS 2 BP 191 EP 201 AR PII S0924-2031(02)00026-7 DI 10.1016/S0924-2031(02)00026-7 PG 11 WC Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA 608HN UT WOS:000178840500009 ER PT J AU Viputtijul, K de Souza, M Trichavaroj, R Carr, JK Tovanabutra, S McCutchan, FE Sriplienchan, S Buapunth, P Chuenchitra, C McNeil, JG Birx, DL Brown, AE Nitayaphan, S AF Viputtijul, K de Souza, M Trichavaroj, R Carr, JK Tovanabutra, S McCutchan, FE Sriplienchan, S Buapunth, P Chuenchitra, C McNeil, JG Birx, DL Brown, AE Nitayaphan, S TI Heterosexually acquired CRF01_AE/B recombinant HIV type 1 found in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE SUBTYPES AB CRF01_AE and subtype B are circulating in Thailand and the strains have become intermixed in some high-risk groups, establishing the possibility of intersubtype recombination. The first such recombinant, mostly B with gp120 from CRF01_AE, was recently identified. Here we report a heterosexually acquired recombinant of different structure, with most of the genome from CRF01_AE but almost the entire envelope from subtype B. Surveillance by V3 serotype and genotype in multiple regions, followed by full-genome sequencing, was used to identify this strain. Pending vaccine trials in Thailand require knowledge of the presence of such strains in the population, and these recombinants provide valuable reagents for the laboratory evaluation of cross-subtype immunity. Studies are underway to determine whether either recombinant is circulating widely. C1 Armed Forces Res Inst Med Sci, Henry M Jackson Fdn, Dept Retrovirol, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Thai Component, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, US Component, Bangkok 10400, Thailand. Henry M Jackson Fdn, Rockville, MD 20850 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. Walter Reed Army Inst Res, Rockville, MD 20850 USA. RP de Souza, M (reprint author), Armed Forces Res Inst Med Sci, Henry M Jackson Fdn, Dept Retrovirol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. NR 11 TC 18 Z9 20 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2002 VL 18 IS 16 BP 1235 EP 1237 DI 10.1089/08892220260387986 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 612FD UT WOS:000179063100009 PM 12494923 ER PT J AU Prue-Owens, KK Hartung, GH AF Prue-Owens, KK Hartung, GH TI Improving quality of care outcomes: Use of the Internet to provide follow-up educational information and support to cardiac patients after cardiac rehabilitation SO AMERICAN HEART JOURNAL LA English DT Meeting Abstract CT 3rd Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke CY SEP 30-OCT 01, 2001 CL WASHINGTON, D.C. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD NOV PY 2002 VL 144 IS 5 MA 101 BP 923 EP 924 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 615NJ UT WOS:000179252400123 ER PT J AU Harrison, SA Kadakia, S Lang, KA Schenker, S AF Harrison, SA Kadakia, S Lang, KA Schenker, S TI Nonalcoholic steatohepatitis: What we know in the new millennium SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Review ID FATTY LIVER-DISEASE; TUMOR-NECROSIS-FACTOR; INDUCED INSULIN-RESISTANCE; GENE-EXPRESSION; FACTOR-ALPHA; WEIGHT-LOSS; CRYPTOGENIC CIRRHOSIS; LEPTIN-DEFICIENT; ADIPOSE-TISSUE; OBESE PATIENTS AB Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by diffuse fatty infiltration and inflammation. The exact prevalence of NASH is unclear, but it is becoming more evident that the disease is much more common than previously thought. Although generally a benign, indolent process, it can progress to advanced liver disease in approximately 15-20% of patients. Clinical characteristics associated with NASH include obesity, hyperlipidemia, diabetes mellitus, and hypertension, all of which have been associated with underlying insulin resistance. Typically, this disease becomes evident in the fourth or fifth decade of life with an equal sex predilection. NASH is thought to be caused, in part, by impaired insulin signaling, leading to elevated circulating insulin levels and subsequent altered lipid homeostasis. This process is likely multifactorial and includes both genetic and environmental factors. Treatment options to date are limited and are based on very small clinical trials. Current investigations are focusing on improving the underlying insulin resistance that has been associated with NASH as well as other therapies that decrease oxidative stress or improve hepatocyte survival. (C) 2002 by Am. Coll. of Gastroenterology. C1 Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Dept Gastroenterol, San Antonio, TX 78236 USA. Univ Texas, Hlth Sci Ctr, Dept Gastroenterol, San Antonio, TX USA. RP Harrison, SA (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 109 TC 117 Z9 129 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD NOV PY 2002 VL 97 IS 11 BP 2714 EP 2724 AR PII S0002-9270(02)05486-2 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 613DH UT WOS:000179116100011 PM 12425538 ER PT J AU Abbott, KC AF Abbott, KC TI High incidence of pulmonary embolus in hemodialysis patients? Reply SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD NOV PY 2002 VL 40 IS 5 BP 1108 EP 1108 DI 10.1053/ajkd.2002.37030 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 611ZA UT WOS:000179047100031 ER PT J AU Cho, S Atwood, JE AF Cho, S Atwood, JE TI Peripheral edema SO AMERICAN JOURNAL OF MEDICINE LA English DT Review ID VENTRICULAR SYSTOLIC DYSFUNCTION; CONGESTIVE-HEART-FAILURE; PRIMARY-CARE; NATRIURETIC PEPTIDE; PLASMA HORMONES; RENAL-FUNCTION; BODY-WATER; DIAGNOSIS; MYXEDEMA; THERAPY AB Peripheral edema often poses a dilemma for the clinician because it is a nonspecific finding common to a host of diseases ranging from the benign to the potentially life threatening. A rational and systematic approach to the patient with edema allows for prompt and cost-effective diagnosis and treatment. This article reviews the pathophysiologic basis of edema formation as a foundation for understanding the mechanisms of edema formation in specific disease states, as well as the implications for treatment. Specific etiologies are reviewed to compare the diseases that manifest this common physical sign. Finally, we review the clinical approach to diagnosis and treatment strategies. (C)2002 by Excerpta Medica, Inc. C1 Veterans Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA. Stanford Univ, Med Ctr, Dept Internal Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA. RP Atwood, JE (reprint author), Walter Reed Army Med Ctr, Dept Cardiol, Bldg 2,6900 Georgia NW, Washington, DC 20307 USA. NR 52 TC 64 Z9 66 U1 0 U2 3 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD NOV PY 2002 VL 113 IS 7 BP 580 EP 586 AR PII S0002-9343(02)01322-0 DI 10.1016/S0002-9343(02)01322-0 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 619BR UT WOS:000179453900008 PM 12459405 ER PT J AU Weightman, GW AF Weightman, GW TI Scientific evidence supports anthrax vaccination SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Letter C1 USA, Falls Church, VA USA. RP Weightman, GW (reprint author), 5109 Leesburg Pike, Falls Church, VA 22041 USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 2002 VL 92 IS 11 BP 1707 EP 1708 DI 10.2105/AJPH.92.11.1707-a PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 608VU UT WOS:000178868600004 PM 12406785 ER PT J AU Toffel, PH Christensen, J AF Toffel, PH Christensen, J TI Epstein-Barr virus - Mild Acquired Immune Deficiency Syndrome (EBV-MAIDS) in postsurgical sinusitis SO AMERICAN JOURNAL OF RHINOLOGY LA English DT Article; Proceedings Paper CT 47th Annual Meeting of the American-Rhinological-Society CY SEP 08, 2001 CL DENVER, COLORADO SP Amer Rhinol Soc ID CHRONIC FATIGUE SYNDROME; INFECTIOUS-MONONUCLEOSIS AB Background: Functional endoscopic sinus surgery has remarkably improved the treatment of chronic rhinosinusitis patients. Computed tomography, endoscopic optical instrumentation, powered microdebriders, and computer-assisted surgery have surmounted the technical problems of obstructive sinusitis care. Most experienced practitioners achieve reported success rates of 85-95% among their surgical patients. However, the 5-15% refractory patients reported by all rhinologic surgeons leave an exasperating and perplexing group who, despite appropriate mechanical corrections, continue to experience debilitating rhinosinusitis episodes requiring repeated oral, nebulized, or intravenous antibiotics, and in some cases, antifungal therapy. Methods: Recent studies have indicated that host immune response mechanisms may be altered in the paranasal sinus tissues of sinusitis patients. After years of observation, it was felt that these difficult patients may suffer from a common thread of significant partial immunocompromise. Drawing on military experience of treating immunoimmature populations prone to Epstein-Barr virus (EBV) infectious mononucleosis and the consequent postmononucleosis syndrome, it was sought to screen disabled refractory postsurgical sinusitis patients for this factor and treat them with long-standing military protocols for the immunoimmature populations dispatched to third-world combat conditions. Results: Treatment of Epstein-Barr Virus-Mild Acquired Immune Deficiency Syndrome consisted of periodic intramuscular serum immune globulin injections (immunomodulator therapy), after obtaining their thorough written informed consent, which produced substantial and sustainable improvement in patient's quality of life. Conclusion: Detection of mild-to-moderate acquired immune deficiency among postsurgical rhinosinusitis patients can lead to successful treatment and an improved quality of life. C1 Univ So Calif, Sch Med, Dept Otolaryngol Head & Neck Surg, Glendale, CA 91208 USA. USA, Naval Med Corp, Glendale, CA USA. Univ Calif Santa Barbara, Dept Microbiol, Santa Barbara, CA 93106 USA. RP Toffel, PH (reprint author), Univ So Calif, Sch Med, Dept Otolaryngol Head & Neck Surg, 1808 Verdugo Blvd,Suite 418, Glendale, CA 91208 USA. NR 21 TC 3 Z9 4 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1050-6586 J9 AM J RHINOL JI Am. J. Rhinol. PD NOV-DEC PY 2002 VL 16 IS 6 BP 291 EP 295 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 630DJ UT WOS:000180092000001 PM 12512902 ER PT J AU Bui-Mansfield, LT Kaplan, KJ AF Bui-Mansfield, LT Kaplan, KJ TI Spindle cell lipoma of the upper back SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 Keller Army Community Hosp, Dept Radiol, W Point, NY 10996 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Winston Salem, NC 27157 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Bui-Mansfield, LT (reprint author), Keller Army Community Hosp, Dept Radiol, 900 Washington Rd, W Point, NY 10996 USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2002 VL 179 IS 5 BP 1158 EP 1158 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 606GG UT WOS:000178725800011 PM 12388491 ER PT J AU Bucci, JR Oglesby, RJ Agodoa, LY Abbott, KC AF Bucci, JR Oglesby, RJ Agodoa, LY Abbott, KC TI Hospitalizations for total hip arthroplasty after renal transplantation in the United States SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE African American; age; avascular necrosis of the hip; body mass index; Caucasian; complications; diabetes; female; gender; mortality; rejection; renal transplant; repeat; revision; risk; total hip arthroplasty; USRDS ID PROSPECTIVE-PAYMENT SYSTEM; AVASCULAR NECROSIS; ASEPTIC NECROSIS; DISEASE; COMPLICATIONS; CHILDREN; FAILURE; RISK AB The national incidence of and factors associated with total hip arthroplasty in renal transplant recipients has not been reported. We conducted an historical cohort study of 42096 renal transplant recipients in the United States between 1 July 1994 and 30 June 1998. Primary outcomes were associations with hospitalizations for a primary discharge code of total hip arthroplasty (ICD9 procedure code 81.51x) within 3 years after renal transplant using Cox regression. Renal transplant recipients had a cumulative incidence of total hip arthroplasty of 5.1 episodes/1000 person-years, which is 5-8 times higher than reported in the general population. Avascular necrosis of the hip was the most frequent primary diagnosis associated with total hip arthroplasty in this population (72% of cases). Repeat surgeries were performed in 27% of patients with avascular necrosis, vs. 15% with other diagnoses. Total hip arthroplasty was more frequent in transplant recipients who were older, African American, or who experienced allograft rejection. Mortality after total hip arthroplasty was 0.21% at 30 days and 15% at 3 years, similar to the mortality of all transplant recipients. The most common indication for total hip arthroplasty after renal transplant is avascular necrosis of the hip, in contrast to the general population. Although repeat surgeries are common, total hip arthroplasty is well tolerated and is not associated with increased mortality in this population. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. NIDDK, NIH, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 29 TC 21 Z9 24 U1 0 U2 1 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD NOV PY 2002 VL 2 IS 10 BP 999 EP 1004 DI 10.1034/j.1600-6143.2002.21020.x PG 6 WC Surgery; Transplantation SC Surgery; Transplantation GA 620ZM UT WOS:000179564100020 PM 12482155 ER PT J AU Nasci, RS Komar, N Marfin, AA Ludwig, GV Kramer, LD Daniels, TJ Falco, RC Campbell, SR Brookes, K Gottfried, KL Burkhalter, KL Aspen, SE Kerst, AJ Lanciotti, RS Moore, CG AF Nasci, RS Komar, N Marfin, AA Ludwig, GV Kramer, LD Daniels, TJ Falco, RC Campbell, SR Brookes, K Gottfried, KL Burkhalter, KL Aspen, SE Kerst, AJ Lanciotti, RS Moore, CG TI Detection of West Nile virus-infected mosquitoes and seropositive juvenile birds in the vicinity of virus-positive dead birds SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NEW-YORK-CITY; NORTHEASTERN UNITED-STATES; LOUIS ENCEPHALITIS-VIRUS; CULEX MOSQUITOS; OUTBREAK; IDENTIFICATION; SURVEILLANCE; ASSAY AB Mosquitoes and wild birds were collected from three sites near locations in the New York City metropolitan area where single, West Nile (WN) virus-positive dead birds were found early in the 2000 transmission season. The mosquitoes were tested for the presence of infectious virus with a Vero cell culture assay and for WN viral RNA by using reverse transcriptase-polymerase chain reaction (RT-PCR) protocols. Serum samples from wild birds were tested for the presence of neutralizing antibodies against WN virus. Infectious WN virus and WN viral RNA were found in Cidex species adult mosquitoes from each of the three sites, and a seropositive hatch-year house sparrow (Passer domesticus) was found in one of the three sites. Molecular techniques used to identify the species in the positive mosquito pools found that most of the pools contained a combination of Cidex pipiens and Cx. restuans. The minimum infection rate in Culex species mosquitoes from the sites ranged from 0.2 to 6.0 per 1,000 specimens tested. The results demonstrated that, at least early in the transmission season, detection of a WN virus-positive dead bird indicates a local WN virus transmission cycle. This information is valuable in focusing subsequent surveillance and vector management programs. In addition, the RT-PCR procedure for detecting WN viral RNA in mosquito pools detected more positive pools than did the Vero cell plaque assay. C1 Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. New York State Dept Hlth, Wadsworth Ctr Lab & Res, Arbovirus Lab, Slingerlands, NY 12159 USA. Fordham Univ, Louis Calder Ctr, Vector Ecol Lab, Armonk, NY 10504 USA. Suffolk Cty Dept Hlth, Yaphank, NY 11980 USA. RP Nasci, RS (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, POB 2087,Foothills Campus,Rampart Rd, Ft Collins, CO 80522 USA. NR 31 TC 35 Z9 40 U1 0 U2 10 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2002 VL 67 IS 5 BP 492 EP 496 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 619VH UT WOS:000179497800009 PM 12479550 ER PT J AU Coleman, RE Sangkasuwan, V Suwanabun, N Eamsila, C Mungviriya, S Devine, P Richards, AL Rowland, D Ching, WM Sattabongkot, J Lerdthusnee, K AF Coleman, RE Sangkasuwan, V Suwanabun, N Eamsila, C Mungviriya, S Devine, P Richards, AL Rowland, D Ching, WM Sattabongkot, J Lerdthusnee, K TI Comparative evaluation of selected diagnostic assays for the detection of IGG and IGM antibody to Orientia tsutsugamushi in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED IMMUNOSORBENT ASSAYS; SCRUB TYPHUS PATIENTS; DOT-BLOT IMMUNOASSAY; PROTEIN ANTIGEN R56; RICKETTSIAL DISEASES; LABORATORY DIAGNOSIS; RAPID DIAGNOSIS; SERODIAGNOSIS; EXPRESSION; INFECTIONS AB We compared the performance of 2 commercially available dipstick assays, 2 enzyme-linked immunosorbent assays (ELISAs), and an indirect immunofluorescent antibody (IFA) assay for the diagnosis of scrub typhus, using the indirect immunoperoxidase (IIP) test as the reference standard. The dipstick assays were the Integrated Diagnostics (Baltimore, MD) Dip-S-Ticks Scrub Recombinant (66) dipstick test (INDX assay) and the PanBio (Brisbane, Australia) Scrub Typhus IgM and IgG Rapid Immunochromatographic test (PanBio assay). One of the ELISAs used pooled cell lysates of Karp, Kato, and Gilliam strain Orientia tsutsugamushi as antigen (pooled-antigen ELISA), and the other used a recombinant r56 protein as the antigen (recombinant ELISA). With a panel of 123 positive and 227 negative sera, sensitivity and specificity of the assays were as follows: INDX assay, IgG, 60% and 95%, IgM, 60% and 97%; PanBio assay, IgG, 94% and 96%, IgM, 83% and 93%; IFA (1:400 cutoff), IgG, 91% and 96%, IgM, 85% and 98%; pooled-antigen ELISA, IgG (1: 1600 cutoff), 97 % and 89 %, IgM (1:400 cutoff), 94 % and 91 %; recombinant ELISA, IgG (1: 1600 cutoff), 97% and 92%, IgM (1:400 cutoff), 93% and 94%. Because of its excellent performance and use of a standardized, commercially available antigen, the recombinant ELISA is suitable for use in a diagnostic laboratory, where it may be able to replace the IFA and IIP assays. In contrast, the PanBio dipstick assay was easy to perform and did not require sophisticated equipment, making it suitable for use in rural areas where more sophisticated diagnostic tests such as the ELISA and IFA may not be available. C1 Armed Forces Res Inst Med Sci, USA Med Component, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Royal Thai Army Component, Div Res, Bangkok 10400, Thailand. USN, Med Res Inst, Rickettsial Dis Dept, Silver Spring, MD 20910 USA. PanBio Pty Ltd, Brisbane, Qld 4030, Australia. RP Coleman, RE (reprint author), USAMC, AFRIMS, Dept Entomol, APO, AP 96546 USA. NR 30 TC 65 Z9 69 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2002 VL 67 IS 5 BP 497 EP 503 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 619VH UT WOS:000179497800010 PM 12479551 ER PT J AU Sanders, JW Isenbarger, DW Walz, SE Pang, LW Scott, DA Tamminga, C Oyofo, BA Hewitson, WC Sanchez, JL Pitarangsi, C Echeverria, P Tribble, DR AF Sanders, JW Isenbarger, DW Walz, SE Pang, LW Scott, DA Tamminga, C Oyofo, BA Hewitson, WC Sanchez, JL Pitarangsi, C Echeverria, P Tribble, DR TI An observational clinic-based study of diarrheal illness in deployed United States military personnel in Thailand: Presentation and outcome of Campylobacter infection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TRAVELERS DIARRHEA; ESCHERICHIA-COLI; CIPROFLOXACIN; RESISTANCE; PATHOGENS; ETIOLOGY; JEJUNI; AZITHROMYCIN; FEATURES; VIRUSES AB Campylobacter is a leading cause of traveler's diarrhea in Thailand. Since resistance to quinolones is high among Campylobacter isolates, empiric therapy with quinolones for traveler's diarrhea may be ineffective in this region. We conducted an observational study among 169 U.S. military personnel with acute diarrhea and compared their microbiologic findings to those of 77 asymptomatic personnel deployed to Thailand in May 1998. Of 146 pathogenic bacterial isolates, the most common were nontyphoidal Salmonella (n = 31), enterotoxigenic Escherichia coli (n = 24), and C. jejuni/coli (n = 23). Campylobacter was strongly associated with disease (odds ratio = 5.9; 95% confidence interval = 1.3-37.3), with a more severe clinical presentation, and with a reduced functional ability at presentation (P = 0.02). In vitro resistance to ciprofloxacin was observed in 96% of the Campylobacter isolates. Sub-optimal treatment response to ciprofloxacin was observed in 17% of the cases of Campylobacter infection versus 6% due to other causes. These results highlight the importance of Campylobacter as a cause of severe traveler's diarrhea in Thailand and illustrates the ongoing problem with antibiotic-resistant strains and associated treatment problems. C1 Natl Naval Med Res Inst, Bethesda, MD 20889 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. USN, Med Res Ctr, Silver Spring, MD 20910 USA. Portsmouth Naval Med Ctr, Portsmouth, VA 23708 USA. USN, Med Res Unit 2, Jakarta, Indonesia. USA, Dept Med, AMEDD Ctr & Sch, Ft Sam Houston, TX 78234 USA. USN, Med Res Ctr Detachment, Unit 3800, Lima, Peru. RP Sanders, JW (reprint author), Natl Naval Med Res Inst, Bethesda, MD 20889 USA. NR 21 TC 58 Z9 58 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2002 VL 67 IS 5 BP 533 EP 538 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 619VH UT WOS:000179497800017 PM 12479558 ER PT J AU Cohen, SP Abdi, S AF Cohen, SP Abdi, S TI Venous malformations associated with central pain: Report of a case SO ANESTHESIA AND ANALGESIA LA English DT Article ID CENTRAL POSTSTROKE PAIN; NEUROPATHIC PAIN; THALAMIC PAIN; INJURY; MODEL; TRIAL; RAT C1 NYU, Sch Med, Dept Anesthesiol, New York, NY 10016 USA. Harvard Univ, Massachusetts Gen Hosp, Sch Med, MGH Pain Ctr,Dept Anesthesia & Crit Care, Boston, MA USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Anesthesiol, Pain Management Ctr, Washington, DC 20307 USA. RP Cohen, SP (reprint author), NYU, Sch Med, Dept Anesthesiol, 550 1st Ave, New York, NY 10016 USA. NR 18 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 2002 VL 95 IS 5 BP 1358 EP 1360 DI 10.1213/01.ANE.0000033100.62362.4A PG 3 WC Anesthesiology SC Anesthesiology GA 609NV UT WOS:000178912600048 PM 12401626 ER PT J AU Davis, LD Zhang, W Merseburger, A Young, D Xu, L Rhim, JS Moul, JW Srivastava, S Sesterhenn, IA AF Davis, LD Zhang, W Merseburger, A Young, D Xu, L Rhim, JS Moul, JW Srivastava, S Sesterhenn, IA TI p63 expression profile in normal and malignant prostate epithelial cells SO ANTICANCER RESEARCH LA English DT Article DE p63; tumor suppressor gene; p53 gene family; prostate; basal cells; cancer; p53 ID P53 HOMOLOG; TRANSFECTION; PROTEIN; PLASMID; CANCER AB p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells. C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 28 TC 25 Z9 26 U1 0 U2 2 PU INT INST ANTICANCER RESEARCH PI ATHENS PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE SN 0250-7005 J9 ANTICANCER RES JI Anticancer Res. PD NOV-DEC PY 2002 VL 22 IS 6C BP 3819 EP 3825 PG 7 WC Oncology SC Oncology GA 637MA UT WOS:000180514600003 PM 12553000 ER PT J AU Duma, SM Jernigan, V Stitzel, JD Herring, IP Crowley, JS Brozoski, FT Bass, CR AF Duma, SM Jernigan, V Stitzel, JD Herring, IP Crowley, JS Brozoski, FT Bass, CR TI The effect of frontal air bags on eye injury patterns in automobile crashes SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article ID IN-SITU KERATOMILEUSIS; MOTOR-VEHICLE COLLISIONS; SEVERE OCULAR TRAUMA; SIDE IMPACT CRASHES; RADIAL KERATOTOMY; ANGLE-RECESSION; PHOTOREFRACTIVE KERATECTOMY; HEXAGONAL KERATOTOMY; CYCLODIALYSIS CLEFT; REFRACTIVE SURGERY AB Objective: To investigate eye injuries resulting from frontal automobile crashes and to determine the effects of frontal air bags. Methods: The National Automotive Sampling System database files from January 1, 1993, through December 31, 1999, were examined in a 3-part study that included an investigation of 22236 individual crashes that occurred in the United States. A new 4-level eye injury severity scale that quantifies injuries based on recovery time, need for surgery, and possible loss of sight was developed. Results: Of all occupants who were exposed to an air bag deployment, 3% sustained an eye injury. In contrast, 2% of occupants not exposed to an air bag deployment sustained an eye injury. A closer examination of the type of eye injuries showed that there was a statistically significant increase in the risk of corneal abrasions for occupants who were exposed to an air bag compared with those who were not (P=.03). Of occupants exposed to an air bag deployment, 0.5% sustained a corneal abrasion compared with 0.04% of occupants who were not exposed to an air bag. Conclusions: Using the new injury levels, it was shown that although occupants exposed to an air bag deployment had a higher risk of sustaining minor eye injuries, the air bag appears to have provided a beneficial exchange by reducing the number of severe eye injuries. C1 Virginia Polytech Inst & State Univ, Impact Biomech Lab, Blacksburg, VA 24061 USA. USA, Aeromed Res Lab, Ft Rucker, AL USA. Univ Virginia, Automobile Safety Lab, Charlottesville, VA USA. RP Duma, SM (reprint author), Virginia Polytech Inst & State Univ, Impact Biomech Lab, 114 Randolph Hall, Blacksburg, VA 24061 USA. RI Duma, Stefan/A-8368-2012; Stitzel Jr, Joel/B-4045-2012; Herring, Ian/S-5421-2016 OI Herring, Ian/0000-0002-3493-5969 NR 91 TC 38 Z9 38 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD NOV PY 2002 VL 120 IS 11 BP 1517 EP 1522 PG 6 WC Ophthalmology SC Ophthalmology GA 614RE UT WOS:000179203400012 PM 12427066 ER PT J AU Stiles, BG Hale, ML Marvaud, JC Popoff, MR AF Stiles, BG Hale, ML Marvaud, JC Popoff, MR TI Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex SO BIOCHEMICAL JOURNAL LA English DT Article DE channel; cytotoxicity; monoclonal antibody; oligomer; protoxin ID BOTULINUM C2 TOXIN; ANTHRAX TOXIN; PROTECTIVE ANTIGEN; RECEPTOR-BINDING; MAMMALIAN-CELLS; ADP-RIBOSYLATION; COMPONENT C2II; LIPID BILAYERS; LETHAL FACTOR; BINARY TOXIN AB Clostridium perfringens type E iota toxin consists of two unlinked proteins designated as iota a (Ia; molecular mass approximate to 47 kDa), an ADP-ribosyltransferase and iota b (Ib; molecular mass approximate to 81 kDa) which binds to the cell surface and facilitates Ia entry into the cytosol. By Western-blot analysis, Ib incubated with Vero cells at 37 degreesC generated a cell-associated, SDS-insoluble oligomer of lb (molecular mass > 220 kDa) within 15 s, which was still evident 110 min after washing cells. lb oligomerization was temperature, but not pH, dependent and was facilitated by a cell-surface protein(s). Within 5 min at 37 degreesC, cell-bound lb generated Na+/K+ permeable channels that were blocked by Ia. However, Ib-induced channels or oligomers were not formed at 4 degreesC. Two monoclonal antibodies raised against lb that recognize unique, neutralizing epitopes within residues 632-655 either inhibited Ib binding to cells and/or oligomerization, unlike a non-neutralizing monoclonal antibody that binds within Ib residues 28-66. The lb protoxin (molecular mass approximate to 98 kDa), which does not facilitate iota cytotoxicity but binds to Vero cells, did not oligomerize or form ion-permeable channels on cells, and neither trypsin nor chymotrypsin treatment of cell-bound lb protoxin induced large complex formation. The link between lb oligomers and iota toxicity was also apparent with a resistant cell line (MRC-5), which bound to lb with no evidence of oligomerization. Overall, these studies revealed that the biological activity of iota toxin is dependent on a long-lived, cell-associated lb complex that rapidly forms ion-permeable channels in cell membranes. These results further reveal the similarities of C. perfringens iota toxin with other bacterial binary toxins produced by Bacillus anthracis and C. botulinum. C1 USA, Med Res Inst Infect Dis, Toxinol Div, Dept Immunol & Mol Biol, Frederick, MD 21702 USA. Inst Pasteur, Unite Toxines Microbiennes, F-75724 Paris, France. RP Stiles, BG (reprint author), USA, Med Res Inst Infect Dis, Toxinol Div, Dept Immunol & Mol Biol, Frederick, MD 21702 USA. NR 42 TC 28 Z9 30 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON W1N 3AJ, ENGLAND SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD NOV 1 PY 2002 VL 367 BP 801 EP 808 DI 10.1042/BJ20020566 PN 3 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 614FP UT WOS:000179177900025 PM 12175336 ER PT J AU Zhang, WH Smith, LA Plantz, BA Schlegel, VL Meagher, MM AF Zhang, WH Smith, LA Plantz, BA Schlegel, VL Meagher, MM TI Design of methanol feed control in Pichia pastoris fermentations based upon a growth model SO BIOTECHNOLOGY PROGRESS LA English DT Article ID PROTEIN; SENSOR AB The methylotrophic yeast Pichia pastoris is an effective system for recombinant protein productions that utilizes methanol as an inducer, and also as carbon and energy source for a Mut(+) (methanol utilization plus) strain. Pichia fermentation is conducted in a fed-batch mode to obtain a high cell density for a high productivity. An accurate methanol control is required in the methanol fed-batch phase (induction phase) in the fermentation. A simple "on-off'' control strategy is inadequate for precise control of methanol concentrations in the fermentor. In this paper we employed a PID (proportional, integral and derivative) control system for the methanol concentration control and designed the PID controller settings on the basis of A Pichia growth model. The closed-loop system was built with four components: PID controller, methanol feed pump, fermentation process, and methanol sensor. First, modeling and transfer functions for all, components were derived, followed by frequency response analysis, a powerful method for calculating the optimal PID parameters K-c (controller gain), tau(I) (controller integral time constant), and tau(D) (controller derivative time constant). Bode stability criteria were used to develop the stability diagram for evaluating the designed settings during the entire methanol fed-batch phase. Fermentations were conducted using four Pichia strains, each expressing a different protein, to verify the control, performance with optimal PID settings. The results showed that the methanol concentration matched the set point very well with only small overshoot when the set point was switched, which indicated that a very good control performance was achieved. The method, developed in this paper is robust and can serve as a framework for the design of other. PID feedback control systems in biological processes. C1 Univ Nebraska, Dept Chem Engn, Lincoln, NE 68583 USA. Univ Nebraska, Dept Food Sci & Technol, Lincoln, NE 68583 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Zhang, WH (reprint author), Univ Nebraska, Dept Chem Engn, Lincoln, NE 68583 USA. NR 9 TC 31 Z9 32 U1 1 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD NOV-DEC PY 2002 VL 18 IS 6 BP 1392 EP 1399 DI 10.1021/bp025516w PG 8 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 624KZ UT WOS:000179760000034 PM 12467476 ER PT J AU D'Agostino, MD Bernasconi, A Das, S Bastos, A Valerio, RM Palmini, A da Costa, JC Scheffer, IE Berkovic, S Guerrini, R Dravet, C Ono, J Gigli, G Federico, A Booth, F Bernardi, B Volpi, L Tassinari, CA Guggenheim, MA Ledbetter, DH Gleeson, JG Lopes-Cendes, I Vossler, DG Malaspina, E Franzoni, E Sartori, RJ Mitchell, MH Mercho, S Dubeau, F Andermann, F Dobyns, WB Andermann, E AF D'Agostino, MD Bernasconi, A Das, S Bastos, A Valerio, RM Palmini, A da Costa, JC Scheffer, IE Berkovic, S Guerrini, R Dravet, C Ono, J Gigli, G Federico, A Booth, F Bernardi, B Volpi, L Tassinari, CA Guggenheim, MA Ledbetter, DH Gleeson, JG Lopes-Cendes, I Vossler, DG Malaspina, E Franzoni, E Sartori, RJ Mitchell, MH Mercho, S Dubeau, F Andermann, F Dobyns, WB Andermann, E TI Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females SO BRAIN LA English DT Article DE DCX; double cortex; LIS1; male; subcortical band heterotopia ID DOUBLE-CORTEX-SYNDROME; DIFFUSE CORTICAL DYSPLASIA; PLATELET-ACTIVATING-FACTOR; DIEKER LISSENCEPHALY GENE; LENNOX-GASTAUT SYNDROME; REELER-LIKE PHENOTYPE; NEURONAL MIGRATION; LAMINAR HETEROTOPIA; LIS1 GENE; CORPUS CALLOSOTOMY AB Subcortical band heterotopia (SBH) or double cortex syndrome is a neuronal migration disorder, which occurs very rarely in males: to date, at least 110 females but only 11 in males have been reported. The syndrome is usually associated with mutations in the doublecortin (DCX) (Xq22.3-q23) gene, and much less frequently in the LIS1 (17p13.3) gene. To determine whether the phenotypic spectrum, the genetic basis and genotype-phenotype correlations of SBH in males are similar to those in females, we compared the clinical, imaging and molecular features in 30 personally evaluated males and 60 previously reported females with SBH. Based on the MRI findings, we defined the following band subtypes: partial, involving one or two cerebral lobes; intermediate, involving two lobes and a portion of a third; diffuse, with substantial involvement of three or more lobes; and pachygyria-SBH, in which posterior SBH merges with anterior pachygyria. Karyo typing and mutation analysis of DCX and/or LIS1 were performed in 23 and 24 patients, respectively. The range of clinical phenotypes in males with SBH greatly overlapped that in females. MRI studies revealed that some anatomical subtypes of SBH, such as partial and intermediate posterior, pachygyria-SBH and diffuse bands with posterior predominance, were more frequently or exclusively present in males. Conversely, classical diffuse SBH and diffuse bands with anterior predominance were more frequent in females. Males had either mild or the most severe band subtypes, and these correlated with the over-representation of normal/borderline intelligence and severe mental retardation, respectively. Conversely, females who had predominantly diffuse bands exhibited mostly mild or moderate mental retardation. Seven patients (29%) had missense mutations in DCX; in four, these were germline mutations, whereas in three there was evidence for somatic mosaicism. A germline missense mutation of LIS1 and a partial trisomy of chromosome 9p were identified in one patient (4%) each. One male each had a possible pathogenic intronic base change in both DCX and LIS1 genes. Our study shows that SBH in males is a clinically heterogeneous syndrome, mostly occurring sporadically. The clinical spectrum is similar to that of females with SBH. However, the greater cognitive and neuroradiological heterogeneity and the small number of mutations identified to date in the coding sequences of the DCX and LIS1 genes in males differ from the findings in females. This suggests other genetic mechanisms such as mutations in the non-coding regions of the DCX or LIS1 genes, gonadal or somatic mosaicism, and finally mutations of other genes. C1 McGill Univ, Montreal Neurol Hosp & Inst, Dept Human Genet, Neurogenet Unit, Montreal, PQ H3A 2B4, Canada. McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada. McGill Univ, Montreal Neurol Hosp & Inst, Dept Pediat, Montreal, PQ H3A 2B4, Canada. Hlth Sci Ctr, Winnipeg, MB, Canada. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Shodair Childrens Hosp, Pediat Neurol Serv, Helena, MT USA. Univ Calif San Diego, Dept Neurosci, Div Pediat Neurol, San Diego, CA 92103 USA. Swedish Med Ctr, Epilepsy Ctr, Seattle, WA USA. Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. Univ Sao Paulo, Clin Hosp, Sao Paulo, Brazil. Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Porto Alegre Epilepsy Surg Program, Porto Alegre, RS, Brazil. Univ Estadual Campinas, Dept Med Genet, Campinas, SP, Brazil. Univ Melbourne, Austin & Repatriat Med Ctr, Dept Neurol, Melbourne, Vic, Australia. Royal Childrens Hosp, Melbourne, Vic, Australia. Inst Child Hlth, Neurosci Unit, London, England. UCL, Great Ormond St Hosp Children, London, England. Ctr St Paul, Marseille, France. Toyonaka City Hosp, Div Pediat, Toyonaka, Osaka, Japan. Santa Maria della Misericordia Hosp, Dept Neurosci, Udine, Italy. Assoc Anni Verdi, Rome, Italy. Univ Siena, Inst Neurol Sci, Neurometab Unit, I-53100 Siena, Italy. Osped Bellaria CA Pizzardi, Bologna, Italy. Univ Bologna, Ctr Pediat Neurol, Bologna, Italy. RP Andermann, E (reprint author), McGill Univ, Montreal Neurol Hosp & Inst, Dept Human Genet, Neurogenet Unit, 3801 Univ St, Montreal, PQ H3A 2B4, Canada. EM mida@musica.mcgill.ca RI Lopes-Cendes, Iscia/B-9416-2013; Scheffer, Ingrid/G-1668-2013; DaCosta, Jaderson/C-4968-2015; OI Lopes-Cendes, Iscia/0000-0002-6221-6822; Scheffer, Ingrid/0000-0002-2311-2174; DaCosta, Jaderson/0000-0001-6776-1515; FRANZONI, EMILIO/0000-0001-8913-3800; Berkovic, Samuel/0000-0003-4580-841X; Dobyns, William/0000-0002-7681-2844 NR 75 TC 52 Z9 55 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-8950 J9 BRAIN JI Brain PD NOV PY 2002 VL 125 BP 2507 EP 2522 DI 10.1093/brain/awf248 PN 11 PG 16 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 608FH UT WOS:000178834400012 PM 12390976 ER PT J AU Jones, RP Ang, CY Inouye, LS AF Jones, RP Ang, CY Inouye, LS TI Effects of PCB 30 and its hydroxylated metabolites on ecdysteroid-mediated gene expression SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID CELL-PROLIFERATION; BIPHENYLS C1 Engineer Res & Dev Ctr, EP C, Environm Chem Branch, Vicksburg, MS 39180 USA. Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA. Analyt Serv Inc, Vicksburg, MS 39182 USA. RP Jones, RP (reprint author), Engineer Res & Dev Ctr, EP C, Environm Chem Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 13 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD NOV PY 2002 VL 69 IS 5 BP 763 EP 770 DI 10.1007/s00128-002-0126-2 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 605TR UT WOS:000178693600022 PM 12375128 ER PT J AU Rojkind, M Dominguez-Rosales, JA Nieto, N Greenwel, P AF Rojkind, M Dominguez-Rosales, JA Nieto, N Greenwel, P TI Role of hydrogen peroxide and oxidative stress in healing responses SO CELLULAR AND MOLECULAR LIFE SCIENCES LA English DT Review DE hepatic stellate cells; extracellular matrix; fibrosis; wound healing; oxidative stress; organ scarring ID HEPATIC STELLATE CELLS; NF-KAPPA-B; EXTRACELLULAR-SUPEROXIDE DISMUTASE; GROWTH-FACTOR-BETA; H2O2-INDUCED FILAMIN REDISTRIBUTION; COLLAGEN GENE-EXPRESSION; TRANSCRIPTION FACTOR SP1; DNA-BINDING ACTIVITY; SMOOTH MUSCLE ACTIN; NADPH OXIDASE AB Oxidative stress is a host defense mechanism whose involvement in maintaining homeostasis and/or inducing disease has been widely investigated over the past decade. Various reactive oxygen species (ROS) have been defined and the enzymes involved in generating and/or eliminating them have been widely studied. In this review we briefly discuss general mechanisms of oxidative stress and the oxidative stress response of the host. We focus primarily on hydrogen peroxide and summarize the systems involved in its formation and elimination. We describe mechanisms whereby hydrogen peroxide and other ROS can modify protein conformation and, thus, alter protein function, and describe a group of transcription factors whose biological activity is modulated by the redox state of cells. These basic aspects of oxidative stress are followed by a discussion of mechanisms whereby hydrogen peroxide and other ROS can modulate some physiological and pathological processes, with special emphasis on wound healing and scarring of the liver. C1 Walter Reed Army Med Ctr, Dept Clin Invest, Expt Pathol Sect, Washington, DC 20307 USA. Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY USA. Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY USA. RP Rojkind, M (reprint author), Walter Reed Army Med Ctr, Dept Clin Invest, Expt Pathol Sect, 6900 Georgia NW, Washington, DC 20307 USA. FU NIAAA NIH HHS [R01 AA10541, R01 AA12196, R01 AA09231] NR 247 TC 113 Z9 118 U1 2 U2 19 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1420-682X J9 CELL MOL LIFE SCI JI Cell. Mol. Life Sci. PD NOV PY 2002 VL 59 IS 11 BP 1872 EP 1891 DI 10.1007/PL00012511 PG 20 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 627ZX UT WOS:000179968000008 PM 12530519 ER PT J AU Barrett, A Cardello, A Maguire, P Richardson, M Kaletunc, G Lesher, L AF Barrett, A Cardello, A Maguire, P Richardson, M Kaletunc, G Lesher, L TI Effects of sucrose ester, dough conditioner, and storage temperature on long-term textural stability of shelf-stable bread SO CEREAL CHEMISTRY LA English DT Article ID ALPHA-AMYLASE; BREADMAKING; ENZYMES; STARCH; SURFACTANTS; CRUMB AB The effectiveness of a dough conditioner containing an amylase enzyme, surfactants, and a reducing compound on preserving the textural stability of shelf-stable bread was compared with that of sucrose ester. Military-specification Meal, Ready-to-Eat bread was formulated to contain sucrose ester alone, the dough conditioner alone, both in combination, or neither additive. Samples were also stored at 4, 21, and 38degreesC for 12 weeks. Instrumental texture, as determined by uniaxial compression and mathematically fitted stress-strain relationships, and sensory texture, as determined by a trained texture panel, were assessed periodically between 0 and 12 weeks. Both sucrose ester and the dough conditioner yielded stored samples that were softer than the control; sucrose ester was slightly more effective than the dough conditioner in preserving instrumental texture, and the additive combination yielded the lowest firmness parameters. Thermal analysis results were consistent with mechanical and sensory evaluations in showing slightly increased recrystallization of starch in the no-additive formulation. Panelists perceived the samples containing sucrose ester to be much closer to an "ideal" texture compared with those containing the dough conditioner. A partial substitution of the lower cost dough conditioner for higher cost sucrose ester may be possible. C1 USA, Natick Soldier Ctr, Combat Feeding Program, SBCCOM, Natick, MA 01760 USA. USA, Natick Soldier Ctr, Prod Optimizat & Evaluat Team, Natick, MA 01760 USA. Ohio State Univ, Dept Agr & Biol Engn, Columbus, OH 43210 USA. Geocenters Inc, Natick, MA 01760 USA. RP Barrett, A (reprint author), USA, Natick Soldier Ctr, Combat Feeding Program, SBCCOM, Natick, MA 01760 USA. RI Kaletunc, Gonul/B-8806-2012 NR 20 TC 10 Z9 11 U1 1 U2 7 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 USA SN 0009-0352 J9 CEREAL CHEM JI Cereal Chem. PD NOV-DEC PY 2002 VL 79 IS 6 BP 806 EP 811 DI 10.1094/CCHEM.2002.79.6.806 PG 6 WC Chemistry, Applied; Food Science & Technology SC Chemistry; Food Science & Technology GA 612UH UT WOS:000179093500013 ER PT J AU West, BJ AF West, BJ TI The most vulnerable, the least successful and other such extremes SO CHEMICAL PHYSICS LA English DT Article ID ANOMALOUS DIFFUSION; HAMILTONIAN-SYSTEMS; CAPILLARY WAVES; PASSAGE TIME; TRANSPORT; FLUCTUATIONS; REGIME; CHAOS; 1ST AB We investigate the relation between the underlying dynamics of a randomly evolving system and the extrema statistics of such systems. Failure modes, as an exemplar of extreme properties, are considered in independent processes, Fokker-Planck processes and Levy stable processes. Using the diffusional entropy to replace the Kolmogorov-Sinai entropy in the survival probability of a dynamical system, we construct the relation between weak dynamical chaos and the ubiquitous inverse power-law distribution for the survival probability. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Duke Univ, Dept Phys, Durham, NC 27707 USA. USA, Res Off, Engn Directorate, Div Math, Res Triangle Pk, NC 27709 USA. RP Duke Univ, Dept Phys, Durham, NC 27707 USA. EM westb@aro-emh1.army.mil NR 52 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 EI 1873-4421 J9 CHEM PHYS JI Chem. Phys. PD NOV 1 PY 2002 VL 284 IS 1-2 SI SI BP 45 EP 57 AR PII S0301-0104(02)00535-9 DI 10.1016/S0301-0104(02)00535-9 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 613AN UT WOS:000179108100005 ER PT J AU Bologna, M Grigolini, P West, BJ AF Bologna, M Grigolini, P West, BJ TI Strange kinetics: conflict between density and trajectory description SO CHEMICAL PHYSICS LA English DT Article ID STATISTICAL-MECHANICS; FRACTIONAL DIFFUSION; SPORADIC RANDOMNESS; ANOMALOUS DIFFUSION; CHAOTIC SYSTEMS; DYNAMICS; MOTION; WALKS AB We study a process of anomalous diffusion, based on intermittent velocity fluctuations, and we show that its scaling depends on whether we observe the motion of many independent trajectories or that of a Liouville-like equation driven density. The reason for this discrepancy seems to be that the Liouville-like equation is unable to reproduce the multi-scaling properties emerging from trajectory dynamics. We argue that this conflict between density and trajectory might help us to define the uncertain border between dynamics and thermodynamics, and that between quantum and classical physics as well. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy. INFM, I-56127 Pisa, Italy. CNR, Ist Biofis, I-56010 Pisa, Italy. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Grigolini, P (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. RI West, Bruce/E-3944-2017 NR 35 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 J9 CHEM PHYS JI Chem. Phys. PD NOV 1 PY 2002 VL 284 IS 1-2 SI SI BP 115 EP 128 AR PII S0301-0104(02)00543-8 DI 10.1016/S0301-0104(02)00543-8 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 613AN UT WOS:000179108100010 ER PT J AU Difazio, M Jabbari, B AF Difazio, M Jabbari, B TI A focused review of the use of botulinum toxins for low back pain SO CLINICAL JOURNAL OF PAIN LA English DT Article DE back pain; herniated disc; nociceptor; botulinum toxin; botox; myobloc ID DORSAL-ROOT GANGLION; PRIMARY-CARE; DOUBLE-BLIND; UNITED-STATES; REHABILITATION; METAANALYSIS; STIMULATION; TORTICOLLIS; DIAGNOSIS; OUTCOMES AB Chronic low back pain is the second most common illness reported by patients in the United States and accounts for substantial morbidity and health-care resource utilization. Many back and spine stressors can contribute to tissue injury, resulting in acute or chronic pain. In response to injury, biochemical processes that cause inflammation and nerve sensitization increase pain levels and contribute to a cycle of reactivity that further heightens patients' sensitivity to pain stimuli. Treatment of back pain depends on its severity, duration, and underlying cause. Traditional therapeutic options include exercise, oral anti-inflammatory or analgesic medication, antidepressants, physical therapy and, in severe cases, surgery. Unfortunately, dissatisfaction with treatment of back pain is common. Oral medications may not completely alleviate symptoms, and opioid analgesics must be used with caution because of their addictive properties. Surgery does not always produce relief and, in some cases, may even exacerbate the problem. Botulinum toxin, which has already been shown to alleviate pain associated with cervical dystonia and other conditions characterized by muscle spasticity, is now being studied for the treatment of back pain. Preliminary evaluations have shown that this treatment is safe and has the advantage of providing local relief directly to the site of injury or pain, without causing systemic side effects. Initial data from small trials also suggest that botulinum toxin is effective, alleviating back pain in selected patients. On the basis of these promising results, additional study in larger trials is warranted. C1 Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Jabbari, B (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 46 TC 19 Z9 19 U1 3 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-8047 J9 CLIN J PAIN JI Clin. J. Pain PD NOV-DEC PY 2002 VL 18 IS 6 SU S BP S155 EP S162 DI 10.1097/00002508-200211001-00007 PG 8 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 614AV UT WOS:000179165400007 PM 12569963 ER PT J AU Orvis, KL Wisher, RA Bonk, CJ Olson, TM AF Orvis, KL Wisher, RA Bonk, CJ Olson, TM TI Communication patterns during synchronous Web-based military training in problem solving SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE online learning; dispersed groups; computer supported collaborative learning collaboration; military; problem solving AB The nature of communication among geographically dispersed groups of learners using text messaging in a military training environment was assessed. A total of 6601 acts of chat were coded into one of three interaction content categories (social, task, or technology-related) and analyzed for frequency and relative change over time. Results indicated shifting patterns of interaction over the 6-month course; while technology concerns gradually diminished, on task discussion peaked in the middle months and social interactions were higher at the start and end of the training, Overall, student chats were categorized as on-task 55%, social 30%, or technology-related 15%. Examples of chats and focus group data indicated that there was an emphasis on fostering student problem solving within the online course. Published by Elsevier Science Ltd. C1 George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. USA, Inst Res, Alexandria, VA 22333 USA. Indiana Univ, Bloomington, IN 47405 USA. Purdue Univ, W Lafayette, IN 47907 USA. RP Orvis, KL (reprint author), George Mason Univ, Dept Psychol, 4400 Univ Dr, Fairfax, VA 22030 USA. NR 24 TC 16 Z9 16 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD NOV PY 2002 VL 18 IS 6 BP 783 EP 795 AR PII S0747-5632(02)00018-3 DI 10.1016/S0747-5632(02)00018-3 PG 13 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 604XP UT WOS:000178646600014 ER PT J AU Clarke, JA Namburu, RR AF Clarke, JA Namburu, RR TI A distributed computing environment for interdisciplinary applications SO CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE LA English DT Article DE distributed interdisciplinary computing; data model and format; high-performance computing ID LARGE-SCALE AB Practical applications are generally interdisciplinary in nature. Current technology is well matured for addressing individual disciplines but not for interdisciplinary applications. Hence, there is a need to couple the capabilities of several different computational disciplines to address these interdisciplinary applications. One approach is to use coupled or multi-physics software, which typically involves developing and validating the entire software spectrum for a specific application. This will be extremely time consuming thus delaying the delivery of crucial capability to the end-user. The other approach is to integrate individual well-matured computational technology discipline's software thus taking advantage of the existing scalable software, validation investments, and tremendous developments in computational science. This integrated approach requires a consistent data model, data format, data management, seamless data movement, and robust, modular, scalable coupling algorithms. To address these requirements, we have developed a new flexible data exchange mechanism for high-performance computing (HPC) codes and tools, known as the eXtensible Data Model and Format (XDMF). XDMF is part of a larger effort known as the 'Interdisciplinary Computing Environment' (ICE). ICE provides computational engines with the data management, visualizations, and user interface tools necessary to exist in a modern computing environment. Instead of imposing a new programming paradigm on HPC codes, XDMF uses the existing concept of file I/O for distributed coordination. XDMF incorporates Network Distributed Global Memory (NDGM), Hierarchical Data Format version 5 (HDF5), and eXtensible Markup Language (XML) to provide a flexible yet efficient data exchange mechanism. This paper discusses the development and implementation of a distributed computing environment for interdisciplinary applications utilizing the concept of a common data hub. Also, the implementation of XDMF is demonstrated for a typical blast-structure interaction interdisciplinary application. Published in 2002 by John Wiley Sons, Ltd. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM clarke@arl.army.mil NR 13 TC 17 Z9 17 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1532-0626 EI 1532-0634 J9 CONCURR COMP-PRACT E JI Concurr. Comput.-Pract. Exp. PD NOV-DEC PY 2002 VL 14 IS 13-15 BP 1161 EP 1174 DI 10.1002/cpe.685 PG 14 WC Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA 631RE UT WOS:000180179900009 ER PT J AU Weichel, ED Bower, KS Ward, TP Hidayat, A AF Weichel, ED Bower, KS Ward, TP Hidayat, A TI Epicorneal aspergilloma after penetrating keratoplasty SO CORNEA LA English DT Article DE Aspergillus keratitis; fungal keratitis; penetrating keratoplasty ID FUNGAL KERATITIS; BACTERIAL; SPECTRUM; WEAR AB Purpose. To report an epicorneal aspergilloma in a postkeratoplasty patient with a bandage soft contact lens. Methods. Case report of a 77-year-old postkeratoplasty patient who presented with an epicorneal mass under a bandage soft contact lens placed for a nonhealing epithelial defect. On removal of the contact lens, a 4 x 4-mm placoid mass fell free from the corneal surface and was sent for culture and histopathology. Results. Gram stain demonstrated septated branching hyphae, and cultures confirmed the diagnosis of Aspergillus versicolor. Histopathologic sections of the epicorneal mass revealed a full-thickness aspergilloma. Conclusion. Contact lens removal and aggressive antimycotic treatment resulted in epithelial healing and resolution of the keratomycosis. The patient remained stable for 6 months followed by a successful repeat penetrating keratoplasty. C1 Eisenhower Army Med Ctr, Dept Ophthalmol, Ft Gordon, GA 30905 USA. Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. Armed Forces Inst Ophthalmol, Div Ophthalmol Pathol, Washington, DC USA. RP Weichel, ED (reprint author), Eisenhower Army Med Ctr, Dept Ophthalmol, Ft Gordon, GA 30905 USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3740 J9 CORNEA JI Cornea PD NOV PY 2002 VL 21 IS 8 BP 825 EP 827 DI 10.1097/00003226-200211000-00019 PG 3 WC Ophthalmology SC Ophthalmology GA 609QZ UT WOS:000178917200019 PM 12410045 ER PT J AU Chiu, J Ketchum, LH Reid, TJ AF Chiu, J Ketchum, LH Reid, TJ TI Transfusion-sparing hemostatic agents SO CURRENT OPINION IN HEMATOLOGY LA English DT Review ID EPSILON-AMINOCAPROIC ACID; HUMAN MEGAKARYOCYTE GROWTH; RECOMBINANT FACTOR VIIA; ORTHOTOPIC LIVER-TRANSPLANTATION; PLACEBO-CONTROLLED TRIAL; ACUTE MYELOID-LEUKEMIA; ACTIVATED FACTOR-VII; FACTOR PEG-RHUMGDF; OPEN-HEART-SURGERY; TRANEXAMIC ACID AB A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying hemostatic defect. The authors discuss the use of a variety of products to reduce bleeding and minimize transfusion of blood products in the setting of clotting factor deficiency or inhibition, platelet deficiency and/or dysfunction, increased fibrinolysis, therapeutic anticoagulation, and coagulopathies caused by dilution and consumption in the setting of trauma and surgery. The authors primarily focus on the available pharmaceuticals. (C) 2002 Lippincott Williams Wilkins, Inc. C1 Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD 20910 USA. SUNY Buffalo, Buffalo, NY 14260 USA. RP Reid, TJ (reprint author), Walter Reed Army Inst Res, Dept Blood Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 123 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1065-6251 J9 CURR OPIN HEMATOL JI Curr. Opin. Hematol. PD NOV PY 2002 VL 9 IS 6 BP 544 EP 550 DI 10.1097/01.MOH.0000032655.43431.46 PG 7 WC Hematology SC Hematology GA 605RD UT WOS:000178690100014 PM 12394180 ER PT J AU Kobayashi, TT Elston, DM Libow, LF David-Bajar, K AF Kobayashi, TT Elston, DM Libow, LF David-Bajar, K TI A case of bullous plemphigold limited to psoriatic plaques SO CUTIS LA English DT Article ID SKIN DISEASES; PEMPHIGUS FOLIACEUS; PUVA THERAPY; AUTOIMMUNE; COEXISTENCE; VULGARIS; CYCLOSPORINE; ASSOCIATION; ANTIGEN; PATIENT AB Psoriasis occurs with increased incidence in patients with bullous pemphigoid (BP). In this article, we describe the seventh reported English literature case in which the bullous lesions were limited to psoriatic plaques, and we discuss the pathophysiologic mechanisms that might explain this phenomenon. Treatment with acitretin quickly cleared both psorfatic and bullous lesions, suggesting a direct link between the psoriatic inflammatory process and the evolution of bullous lesions. C1 Brooke Army Med Ctr, Dept Dermatol, MCHE, DD, Ft Sam Houston, TX 78234 USA. San Antonio Uniformed Serv, Hlth Educ Consortium, Dept Dermatol, San Antonio, TX USA. RP David-Bajar, K (reprint author), Brooke Army Med Ctr, Dept Dermatol, MCHE, DD, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 37 TC 6 Z9 6 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2002 VL 70 IS 5 BP 283 EP 287 PG 5 WC Dermatology SC Dermatology GA 616NV UT WOS:000179310600005 PM 12469782 ER PT J AU Murphy, ME Boyer, JD Stashower, ME Zitelli, JA AF Murphy, ME Boyer, JD Stashower, ME Zitelli, JA TI The surgical management of Spitz nevi SO DERMATOLOGIC SURGERY LA English DT Article ID EPITHELIOID CELL NEVUS; MALIGNANT-MELANOMA; CHILDHOOD; SPINDLE AB BACKGROUND. The biologic behavior of Spitz nevi and atypical Spitz nevi ranges from completely benign to the rare malignant melanoma. Various recommendations for the surgical approach to these lesions have been proposed. OBJECTIVE. To determine any trend in the surgical management of Spitz nevi and atypical Spitz nevi among a community of dermatologists. METHODS. Retrospective review of the clinical features, surgical management and outcome of 89 patients with the diagnosis of Spitz nevus or atypical Spitz nevus. RESULTS. All biopsy techniques had a high incidence of involved margins: shave (67%), excision (28%), and punch (21%). Of the atypical Spitz nevi with positive margins on biopsy, there was a trend (7/9) toward reexcision with narrow margins (average 2.2 mm). CONCLUSION. The majority of atypical Spitz nevi incompletely removed by biopsy were excised with narrow uncontrolled margins. A stratified surgical approach depending on the clinical and histopathologic features of the Spitz lesion is proposed. More aggressive surgical management of Spitz lesions with atypical features may be warranted. Further studies to determine the biologic potential of these lesions are needed. C1 Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. Natl Naval Med Res Inst, Dept Dermatol, Bethesda, MD USA. Shadyside Hosp, Med Ctr, Pittsburgh, PA 15232 USA. RP Murphy, ME (reprint author), Walter Reed Army Med Ctr, Dept Dermatol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM murphymd@aol.com NR 28 TC 20 Z9 25 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD NOV PY 2002 VL 28 IS 11 BP 1065 EP 1069 DI 10.1046/j.1524-4725.2002.02067.x PG 5 WC Dermatology; Surgery SC Dermatology; Surgery GA 620MA UT WOS:000179536100017 PM 12460304 ER PT J AU Smith, SB Farley, MF Albertini, JG Elston, DM AF Smith, SB Farley, MF Albertini, JG Elston, DM TI Mohs micrographic surgery for granular cell tumor using S-100 immunostain SO DERMATOLOGIC SURGERY LA English DT Editorial Material ID BREAST; EXPRESSION; EXCISION; HEAD; NECK AB BACKGROUND. Granular cell tumor (GCT) is an uncommon tumor of neural origin. Most commonly it is found in the head and neck region and rarely on the foot. The pathologic diagnosis is often confirmed by immunohistochemical staining for S-100 protein. The standard treatment is complete excision. Two previous cases of GCTs treated by Mohs micrographic surgery (MMS) have been reported in the English literature. The immunohistochemical stain S-100 was not used in these cases. OBJECTIVE. Describe the use of S-100 immunohistochemical stain on MMS frozen sections in clearing a GCT of the foot with extension along nerves without involvement of perineurium. METHODS. Tissue was embedded and cut using standard Mohs surgical methodology. Frozen sections were stained with hematoxylin and eosin and with an immunoperoxidase method for S-100 protein using a Ventana automated stainer. RESULTS. MMS in combination with S-100 was successfully performed on a GCT on the plantar surface of our patient's foot. The S-100 immunohistochemical stain was helpful in tracking the extension along nerves of the GCT which was not evident with hematoxylin and eosin alone. CONCLUSION. Using S-100 immunohistochemical stain on the MMS frozen sections can increase the diagnostic accuracy for complete removal of GCT. C1 Brooke Army Med Ctr, Dept Dermatol MCHEDD, San Antonio Uniformed Hlth Serv Educ Consortium, Ft Sam Houston, TX 78234 USA. RP Smith, SB (reprint author), Brooke Army Med Ctr, Dept Dermatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 43 TC 13 Z9 14 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD NOV PY 2002 VL 28 IS 11 BP 1076 EP 1078 DI 10.1046/j.1524-4725.2002.02087.x PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA 620MA UT WOS:000179536100020 PM 12460307 ER PT J AU Xu, K Zhang, SS Poese, BA Jow, TR AF Xu, K Zhang, SS Poese, BA Jow, TR TI Lithium bis(oxalato)borate stabilizes graphite anode in propylene carbonate SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID ION CELLS; ELECTROLYTE; BATTERIES; DECOMPOSITION; INTERCALATION AB This paper summarizes the preliminary results of our recent finding that lithium bis(oxalato)borate (LiBOB) can effectively stabilize graphitic anode materials in neat propylene carbonate (PC) while supporting reversible lithium ion intercalation/deintercalation, a unique behavior hitherto unobserved for any electrolyte salts. This ability of LiBOB to protect graphite from exfoliation in PC offers unprecedented flexibility for the efforts of reformulating lithium-ion electrolytes, where the displacement of the high melting solvent component ethylene carbonate by PC is no longer restricted by the concern of PC instability on graphitic anode surface. (C) 2002 The Electrochemical Society. C1 USA, Res Lab, Sensor & Elect Directorate, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Sensor & Elect Directorate, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 21 TC 124 Z9 134 U1 2 U2 38 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PD NOV PY 2002 VL 5 IS 11 BP A259 EP A262 DI 10.1149/1.1510322 PG 4 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 596CA UT WOS:000178145200007 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI A new approach toward improved low temperature performance of Li-ion battery SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE LiBF4; electrolyte; ionic conductivity; low temperature; Li-ion battery ID CELLS; ELECTROLYTES; LITHIUM AB We report a new approach toward formulating an electrolyte for low temperature operation of Li-ion batteries. The core of this new approach is to use LiBF4 salt instead of LiPF6, which is the chosen solute in the state-of-the-art Li-ion electrolytes. We found that although LiBF4-based electrolyte has lower ionic conductivity than the LiPF6 analogue, it provides improved low temperature performance. In particular, at -30 degreesC, a Li-ion cell with 1 m (mol/kg solvent) LiBF4 dissolved in 1:1:3 (wt.) propylene carbonate (PC)/ethylene carbonate (EC)/ethylmethyl carbonate (EMC) mixed solvent delivers as high as 86% of capacity, in comparison to that obtained at 20 degreesC. Whereas the counterpart one, using LiPF6, only retains 72%. Furthermore, the cell with LiBF4-based electrolyte shows lower polarization at -30 degreesC. The above results suggest that the ionic conductivity of the electrolyte is not the only limitation to the low temperature operation of Li-ion batteries. Analysis of cell impedance reveals that the improved low temperature performance by LiBF4 arises from a reduced charge-transfer resistance. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 15 TC 81 Z9 95 U1 9 U2 54 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD NOV PY 2002 VL 4 IS 11 BP 928 EP 932 AR PII S1388-2481(02)00490-3 DI 10.1016/S1388-2481(02)00490-3 PG 5 WC Electrochemistry SC Electrochemistry GA 617ET UT WOS:000179348900016 ER PT J AU Krinitzsky, EL Hynes, ME AF Krinitzsky, EL Hynes, ME TI The Bhuj, India, earthquake: lessons learned for earthquake safety of dams on alluvium SO ENGINEERING GEOLOGY LA English DT Article DE Bhuj; India; dams; earthquake; alluvium; foundations; soil liquefaction; Kachchh ID LIQUEFACTION AB The Bhuj, India, earthquake of 26 January 2001, M-s 7.9, caused dams built on alluvium to sustain damage ranging from cosmetic to severe. Major damage was caused almost entirely by soil liquefaction in the alluvium. The critical factor was the level of earthquake ground motion. The Bhuj earthquake showed that peak horizontal accelerations (PHAs) less than or equal to 0.2 g were generally safe. PHAs > 0.2 g were hazardous, when unconsolidated granular foundation soils were water saturated. N values of < 20 are indicative of susceptibility to soil liquefaction. The Bhuj experience showed that alluvial foundation soils, subject to a PHA>0.2 g, must be evaluated over the full area beneath a new dam and all soils deemed susceptible to liquefaction must be either removed or treated. For remediating an old dam, reliable options are removal and replacement of liquefiable alluvium beneath upstream and downstream portions of the dam, combined with building berms designed to provide stability for the dam should there be a strength loss in soils beneath the dam. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Corps Engineers, Geotech & Struct Lab, Waterways Expt Stn,Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Krinitzsky, EL (reprint author), USA, Corps Engineers, Geotech & Struct Lab, Waterways Expt Stn,Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 15 TC 15 Z9 19 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD NOV PY 2002 VL 66 IS 3-4 BP 163 EP 196 AR PII S0013-7952(02)00049-2 DI 10.1016/S0013-7952(02)00049-2 PG 34 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 603AB UT WOS:000178535700001 ER PT J AU Kirchner, RF Kondratieff, BC Zuellig, RE AF Kirchner, RF Kondratieff, BC Zuellig, RE TI The tennessee type locality of Allocapnia perplexa and a New Kentucky location for Allocapnia cunninghami (Plecoptera : Capniidae) SO ENTOMOLOGICAL NEWS LA English DT Article AB The type locality stream of the winter stonefly Allocapnia perplexa is putatively identified in Sumner and Trousdale counties, Tennessee. Additionally, a new Kentucky locality for A. cunninghami is noted. Detailed collection records for the above species and A. brooksi are given. All three species are considered imperiled throughout their range. C1 USA, Corps Engineers, Water Qual Sect, Apple Grove, WV 25502 USA. Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA. Colorado State Univ, Dept Fishery & Wildlife Biol, Ft Collins, CO 80523 USA. RP Kirchner, RF (reprint author), USA, Corps Engineers, Water Qual Sect, POB 9, Apple Grove, WV 25502 USA. NR 3 TC 2 Z9 2 U1 1 U2 1 PU AMER ENTOMOL SOC PI PHILADELPHIA PA 1900 BENJ FRANKLIN PARKWAY, PHILADELPHIA, PA 19103-1195 USA SN 0013-872X J9 ENTOMOL NEWS JI Entomol. News PD NOV-DEC PY 2002 VL 113 IS 5 BP 332 EP 335 PG 4 WC Entomology SC Entomology GA 666NZ UT WOS:000182184500011 ER PT J AU Lange, JL Schwartz, DA Doebbeling, BN Heller, JM Thorne, PS AF Lange, JL Schwartz, DA Doebbeling, BN Heller, JM Thorne, PS TI Exposures to the Kuwait oil fires and their association with asthma and bronchitis among Gulf War veterans SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE air pollution; asthma; chronic bronchitis; exposure modeling; geographical information systems; oil-well fires; Persian Gulf War ID POPULATION-BASED SURVEY; HEALTH; SMOKE; STATES; MODEL AB Military personnel deployed to the Persian Gulf War have reported a variety of symptoms attributed to their exposures. We examined relationships between symptoms of respiratory illness present 5 years after the war and both self-reported and modeled exposures to oil-fire smoke that occurred during deployment. Exposure and symptom information was obtained by structured telephone interview in a population-based sample of 1,560 veterans who served in the Gulf War. Modeled exposures were exhaustively developed using a geographic information system to integrate spatial and temporal records of smoke concentrations with troop movements ascertained from global positioning systems records. For the oil-fire period, there were 600,000 modeled data points with solar absorbance used to represent smoke concentrations to a 15-km resolution. Outcomes included respiratory symptoms (asthma, bronchitis) and control outcomes (major depression, injury). Approximately 94% of the study cohort were still in the gulf theater during the time of the oil-well fires, and 21% remained there more than 100 days during the fires. There was modest correlation between self-reported and modeled exposures (r = 0.48, p < 0.05). Odds ratios for asthma, bronchitis, and major depression increased with increasing self-reported exposure. In contrast, there was no association between the modeled exposure and any of the outcomes. These findings do not support speculation that exposures to oil-fire smoke caused respiratory symptoms among veterans. C1 Univ Iowa, Coll Publ Hlth, Dept Environm & Occupat Hlth, Iowa City, IA 52242 USA. Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA. Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA. Vet Affairs Med Ctr, Iowa City, IA 52242 USA. USA, Ctr Hlth Promot & Prevent Med, Deployment Environm Surveillance Program, Aberdeen Proving Ground, MD 21010 USA. RP Thorne, PS (reprint author), Univ Iowa, Coll Publ Hlth, Dept Environm & Occupat Hlth, 100 Oakdale Campus,176 IREH, Iowa City, IA 52242 USA. RI Doebbeling, Bradley/C-6620-2009 NR 26 TC 37 Z9 38 U1 0 U2 2 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2002 VL 110 IS 11 BP 1141 EP 1146 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 614NW UT WOS:000179197100036 PM 12417486 ER PT J AU Sudol, MF Ambrose, RF AF Sudol, MF Ambrose, RF TI The US Clean Water Act and habitat replacement: Evaluation of mitigation sites in Orange County, California, USA SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Clean Water Act Section 404; compensatory mitigation; ecological assessment; habitat creation; mitigation success; restoration; riparian habitat; wetlands; Orange County, California ID REQUIRING COMPENSATORY MITIGATION; SOUTHERN CALIFORNIA; PERMIT PROGRAM; WETLANDS; RESTORATION; IMPACTS; POLICIES AB Both permit requirements and ecological assessments have been used to evaluate mitigation success. This analysis combines these two approaches to evaluate mitigation required under Section 404 of the United States Clean Water Act (CWA) and Section 10 of the Rivers and Harbors Act, which allow developers to provide compensatory mitigation for unavoidable impacts to wetlands. This study reviewed permit files and conducted field assessments of mitigation sites to evaluate the effectiveness of mitigation required by the US Army Corps of Engineers for all permits issued in Orange County, California from 1979 through 1993. The 535 permit actions approved during this period allowed 157 ha of impacts. Mitigation was required on 70 of these actions, with 152 ha of enhanced, restored, and created habitat required for 136 ha of impacts. In 15 permit actions, no mitigation project was constructed, but in only two cases was the originally permitted project built; the two cases resulted in an unmitigated loss of 1.6 ha. Of the remaining 55 sites, 55% were successful at meeting the permit conditions while 11% failed to do so. Based on a qualitative assessment of habitat quality, only 16% of the sites could be considered successful and 26% were considered failures. Thus, of the 126 ha of habitat lost due to the 55 projects, only 26 ha of mitigation was considered successful. The low success rate was not due to poor enforcement, although nearly half of the projects did not comply with all permit conditions. Mitigation success could best be improved by requiring mitigation plans to have performance standards based on habitat functions. C1 Univ Calif Los Angeles, Environm Sci & Engn Program, Los Angeles, CA 90095 USA. USA, Corps Engineers, Regulatory Branch, Los Angeles, CA 90017 USA. RP Ambrose, RF (reprint author), Univ Calif Los Angeles, Environm Sci & Engn Program, Box 951772, Los Angeles, CA 90095 USA. OI Ambrose, Richard/0000-0001-8653-6487 NR 35 TC 16 Z9 17 U1 2 U2 21 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD NOV PY 2002 VL 30 IS 5 BP 727 EP 734 DI 10.1007/s00267-002-2787-3 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 606FE UT WOS:000178722900012 PM 12375092 ER PT J AU Groffman, PM Boulware, NJ Zipperer, WC Pouyat, RV Band, LE Colosimo, MF AF Groffman, PM Boulware, NJ Zipperer, WC Pouyat, RV Band, LE Colosimo, MF TI Soil nitrogen cycle processes in urban Riparian zones SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NITRATE REMOVAL; ORGANIC-CARBON; RIVER BASIN; FOREST; DENITRIFICATION; GROUNDWATER; CATCHMENTS; WATERSHEDS; BENEFITS; COSTS AB Riparian zones have been found to function as "sinks" for, nitrate (NO3-), the most common groundwater pollutant in the U. S., in many areas. The vast majority of riparian research, however, has focused on agricultural watersheds. There has been little analysis of riparian zones in urban watersheds, despite the fact that urban areas are important sources of NO3- to nitrogen (N)-sensitive coastal waters in many locations. In this study, we measured stream incision, water table depths, and pools, production (mineralization, nitrification), and consumption (denitrification) of NO3- in urban soils. Samples were taken from soil profiles (0100 cm) of three forested urban and suburban zones and one forested reference riparian zone in the Baltimore, Maryland metropolitan area. Our objectives were to determine (1) if stream incision associated with urbanization results in lower riparian water tables, and (2) if pools, production, and consumption of NO3- vary systematically with stream incision and riparian water table levels. Two of the three urban and suburban streams were more incised and all three had lower water tables in their riparian zones than the forested reference stream. Urban and suburban riparian zones had higher NO3- pools and nitrification rates than the forested reference riparian zone, which was likely due to more aerobic soil profiles, lower levels of available soil carbon, and greater N enrichment in the urban and suburban sites. At all sites, denitrification potential decreased markedly with depth in the soil profile. Lower water tables in-the urban and suburban,riparian zones thus inhibit interaction of groundwater-borne NO3- with near surface soils that have the highest denitrification potential. These results suggest that urban hydrologic, factors can increase the production and reduce the consumption of NO3- in riparian,zones, reducing their ability to function as sinks for NO3- in the landscape. C1 Inst Ecosyst Studies, Millbrook, NY 12545 USA. US Forest Serv, NE Forest Expt Stn, Syracuse, NY 13210 USA. Univ N Carolina, Dept Geog, Chapel Hill, NC 27514 USA. USA, Corps Engineers, Baltimore, MD 21203 USA. RP Groffman, PM (reprint author), Inst Ecosyst Studies, Box AB, Millbrook, NY 12545 USA. NR 49 TC 147 Z9 152 U1 11 U2 113 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 1 PY 2002 VL 36 IS 21 BP 4547 EP 4552 DI 10.1021/es020649z PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 611ED UT WOS:000179002700027 PM 12433163 ER PT J AU Walton, TL AF Walton, TL TI Setup and setdown in tidal bays and wetlands SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE wetlands; tides; inlets; bays; setup; estuary AB Mean water level elevation change in an idealized inlet and connecting bay is addressed, and analytical results of setup and setdown solutions are discussed. Results of setup and setdown computations are provided for a number of non-dimensionalized inlet-bay system parameters, and parameter sensitivity issues are noted. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Walton, TL (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD NOV PY 2002 VL 55 IS 5 BP 789 EP 794 DI 10.1006/ecss.2001.0940 PG 6 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 620RU UT WOS:000179546900010 ER PT J AU Beeram, M Hammond, L Schwartz, G Patnaik, A Tolcher, A Simmons, C Renshaw, G Rowinsky, E AF Beeram, M Hammond, L Schwartz, G Patnaik, A Tolcher, A Simmons, C Renshaw, G Rowinsky, E TI Phase I and pharmacokinetic study (PK) of the combination of multitargeted antifolate pemetrexed (ALIMTA) with irinotecan (CPT-11) in patients with advanced malignancies SO EUROPEAN JOURNAL OF CANCER LA English DT Meeting Abstract CT 14th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics CY NOV 19-22, 2002 CL FRANKFURT, GERMANY C1 Univ Texas, Hlth Sci Ctr, Inst Drug Dev, Div Med Oncol, San Antonio, TX USA. Inst Drug Dev, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. Eli Lilly & Co, Indianapolis, IN 46285 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0959-8049 J9 EUR J CANCER JI Eur. J. Cancer PD NOV PY 2002 VL 38 SU 7 MA 65 BP S24 EP S25 PG 2 WC Oncology SC Oncology GA 626VZ UT WOS:000179895700064 ER PT J AU Rowinsky, E Schwartz, G Dutcher, J Vogelzang, N Gollob, J Thompson, J Bukowski, R Figlin, R Foon, K Schwab, G AF Rowinsky, E Schwartz, G Dutcher, J Vogelzang, N Gollob, J Thompson, J Bukowski, R Figlin, R Foon, K Schwab, G TI ABX-EGF, a fully human anti-epidermal growth factor receptor (EGFr) monoclonal antibody: phase II clinical trial in renal cell cancer (RCC) SO EUROPEAN JOURNAL OF CANCER LA English DT Meeting Abstract CT 14th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics CY NOV 19-22, 2002 CL FRANKFURT, GERMANY C1 Canc Therapy & Res Ctr S Texas, San Antonio, TX 78229 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Chicago, Chicago, IL 60637 USA. Deaconess Canc Ctr, Boston, MA USA. Univ Washington, Seattle, WA 98195 USA. Cleveland Clin, Cleveland, OH 44106 USA. Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA. Abgenix Inc, Fremont, CA USA. Our Lady Mercy Med Ctr, Bronx, NY USA. NR 0 TC 3 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0959-8049 J9 EUR J CANCER JI Eur. J. Cancer PD NOV PY 2002 VL 38 SU 7 MA 178 BP S57 EP S57 PG 1 WC Oncology SC Oncology GA 626VZ UT WOS:000179895700180 ER PT J AU Noedl, H Wongsrichanalai, C Miller, RS Myint, KSA Looareesuwan, S Sukthana, Y Wongchotigul, V Kollaritsch, H Wiedermann, G Wernsdorfer, WH AF Noedl, H Wongsrichanalai, C Miller, RS Myint, KSA Looareesuwan, S Sukthana, Y Wongchotigul, V Kollaritsch, H Wiedermann, G Wernsdorfer, WH TI Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE Plasmodim falciparum; malaria; protozoa; HRP; histidine-rich protein; ELISA; enzyme-linked immunosorbent assay; drug sensitivity assay; drug resistance; IRBC; infected red blood cell; anti-malarial drug action ID HRP-III; DIAGNOSIS; BLOOD; PARASITES; PLASMA; ASSAY AB Plasmodiumfalciparum histidine-rich protein II (HRP2) is one of the best documented malaria proteins. However, little is known about the development of HRP2 concentrations under the influence of anti-malarial drugs. HRP2 levels were determined in cell medium mixture. cellular compartment, and in culture supernatant using a double-site sandwich ELISA specific for HRP2. Characteristic increases in the overall HRP2 levels were found during the later ring and the trophozoite stages. Throughout the later schizont development, rupture, and reinvasion, however, the HRP2 levels remained comparatively stable. When the cultures were exposed to serial dilutions of anti-malarial drugs, a distinct inhibition of HRP2 production was seen with increasing concentrations of drugs, resulting in sigmoid dose-response curves, similar to those obtained from conventional drug sensitivity assays. HRP2 therefore allows for a very accurate estimation of parasite development and its inhibition and may therefore be ideally suited for use in drug sensitivity or bioassays. (C) 2003 Elsevier Science (USA). All rights reserved. C1 Armed Forces Res Inst Med Sci, USAMC, Dept Immunol Med, Bangkok, Thailand. Univ Vienna, Inst Pathophysiol, Dept Specif Prophylaxis & Trop Med, A-1095 Vienna, Austria. Mahidol Univ, Fac Trop Med, Bangkok Hosp Trop Dis, Bangkok, Thailand. Armed Forces Res Inst Med Sci, USAMC, Dept Virol, Bangkok, Thailand. RP Noedl, H (reprint author), Armed Forces Res Inst Med Sci, USAMC, Dept Immunol Med, Bangkok, Thailand. OI Kollaritsch, Herwig/0000-0001-6393-516X NR 29 TC 33 Z9 33 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD NOV-DEC PY 2002 VL 102 IS 3-4 BP 157 EP 163 DI 10.1016/S0014-4894(03)00051-1 PG 7 WC Parasitology SC Parasitology GA 688UZ UT WOS:000183456500005 PM 12856311 ER PT J AU Lee, C Kim, IY Wood, A AF Lee, C Kim, IY Wood, A TI Investigation and correlation of manikin and bench-scale fire testing of clothing systems SO FIRE AND MATERIALS LA English DT Article AB The US Army currently has five flame/thermal protective clothing systems to provide protection for soldiers against fire hazards. The protective performance of these clothing systems against burn injuries was investigated in full-scale manikin tests. The protective performance of fabric layers of these clothing systems was also examined in bench-scale tests. In addition, air gap thicknesses and distributions of the five clothing systems were determined by using a three-dimensional laser scanning technique. In this paper, test conditions of the manikin and bench-scale tests are compared, and the test results are correlated in light of the air gap measurements. The behavior of individual sensors on the manikin with similar test conditions to those of bench-scale tests are compared with the bench-scale tests. It is found that if the air gap distribution of a clothing system is known, bench-scale tests could provide useful information for full-scale performance, especially bench-scale tests with zero air gap measurements. Published in 2002 by John Wiley Sons, Ltd. C1 USA, Army Soldier & Biol Chem Command, Soldier Syst Ctr, Natick, MA 01760 USA. Worcester Polytech Inst, Worcester, MA 01609 USA. RP Lee, C (reprint author), USA, Army Soldier & Biol Chem Command, Soldier Syst Ctr, Kansas St, Natick, MA 01760 USA. NR 12 TC 21 Z9 22 U1 0 U2 6 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX PO19 1UD, ENGLAND SN 0308-0501 J9 FIRE MATER JI Fire Mater. PD NOV-DEC PY 2002 VL 26 IS 6 BP 269 EP 278 DI 10.1002/fam.808 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 642TU UT WOS:000180821400003 ER PT J AU Tonry, L AF Tonry, L TI Intra-oral x-ray room shielding evaluation SO HEALTH PHYSICS LA English DT Article DE operational topic; x rays; shielding; medical radiation AB OBJECTIVE: To evaluate scatter radiation levels resulting from intra-oral dental exams and determine shielding requirements for dental x-ray rooms using intra-oral x-ray systems. C1 USA, Med Serv Corps, Washington, DC 20310 USA. RP Tonry, L (reprint author), USA, Med Serv Corps, Washington, DC 20310 USA. EM Tonry@se.amedd.army.mil NR 3 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD NOV PY 2002 VL 83 IS 11 SU S BP S60 EP S64 DI 10.1097/00004032-200211005-00005 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 631DR UT WOS:000180152800003 PM 12458921 ER PT J AU Jacobs, EL Lang, RH AF Jacobs, EL Lang, RH TI Scattering, transmission, and absorption by a rough resistive sheet - E polarization SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Method of Moments (MoM); Monte Carlo methods; rough surface; scattering ID SURFACE SCATTERING AB Motivated by the use of thin conducting textiles in absorbers, the interaction of electromagnetic waves with a rough resistive sheet is examined. Expressions for the fields above and below the sheet are derived in terms of an equivalent current using Gaussian beam illumination. These field expressions are then used with equations derived from,the conservation of energy to find the distribution of scattered, transmitted, and absorbed power using an exact numerical solution and the Kirchhoff approximation. As A consequence of the lack of refraction, the Kirchhoff single scattering solution produces strong coherent transmitted intensities at the forward angles With an attendant minimum in the incoherent intensity. A second minimum in the incoherent intensity is observed in the antispecular direction. Fields arising from multiple scattering interactions are observed independent of the Kirchhoff single scatter contributions at these angles for surfaces of large root-mean-square slope. An increase in the absorption in the sheet is also observed as surface roughness is increased. The increase in absorption is believed due to multiple scattering interactions on the surface. C1 USA, CECOM, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. RP Jacobs, EL (reprint author), USA, CECOM, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 20 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD NOV PY 2002 VL 50 IS 11 BP 1567 EP 1576 DI 10.1109/TAP.2002.803967 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 639MY UT WOS:000180634400009 ER PT J AU Torrieri, D AF Torrieri, D TI Simple formula for error probability of rake demodulator for noncoherent binary orthogonal signals and Rayleigh fading SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE rake demodulator; Rayleigh fading; orthogonal signals AB -A simple alternative formula for the error probability of a Rake demodulator for noncoherent, square-law detected, binary orthogonal signals and Rayleigh fading is presented. The formula is more compact and considerably easier to evaluate than the classical formula while providing identical numerical results. The derivation of the alternative formula is shown to be much simpler than the derivation of the classical formula. C1 AMSRL CI C, Army Res Lab, Adelphi, MD 20783 USA. RP Torrieri, D (reprint author), AMSRL CI C, Army Res Lab, Adelphi, MD 20783 USA. NR 1 TC 6 Z9 6 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD NOV PY 2002 VL 50 IS 11 BP 1734 EP 1735 DI 10.1109/TCOMM.2002.805281 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 624EJ UT WOS:000179747100007 ER PT J AU Shah, PB AF Shah, PB TI SiC-GTO thyristor gate and drift-region dopant polarity analysis using electrothermal simulation SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE power semiconductor devices; power semiconductor switches; semiconductor device modeling; semiconductor device reliability; thermal factors; thyristors ID JUNCTION AB Two-dimensional electrothermal simulations were done to improve the reliability of high-power SiC-GTO thyristors. Transient mixed mode results indicate that less device heating occurs in a given number of cycles if the drift and the gate contact regions are both donor doped rather than the conventional design using a donor-doped gated region and an acceptor-doped drift region. The hot spot was also observed to move from beneath the gate at the start of turnoff to the corner formed by mesa isolation and finally end up in the center of the anode finger at the end of the turnoff process. C1 USA, Res Lab, Sensors & Electron Devices Directorate, MS AMSRL SE RL, Adelphi, MD 20783 USA. RP Shah, PB (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, MS AMSRL SE RL, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD NOV PY 2002 VL 49 IS 11 BP 2064 EP 2069 DI 10.1109/TED.2002.804691 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 623GD UT WOS:000179694200029 ER PT J AU Shah, PB Geil, BR Ervin, ME Griffin, TE Bayne, SB Jones, KA Oldham, T AF Shah, PB Geil, BR Ervin, ME Griffin, TE Bayne, SB Jones, KA Oldham, T TI Advanced operational techniques and pn-pn-pn structures for high-power silicon carbide gate turn-off thyristors SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE power semiconductor devices; power semiconductor switches; semiconductor device modeling; semiconductor device reliability; thyristors ID DIVERTOR; DENSITY AB SiC GTO thyristors may soon be the best available choice for very high-power switching. At this time, we have developed new operational techniques, growth requirements and pn-pn-pn type structures to address the issues of high on-state voltage, poor turn-off gain, and inability to reach predicted breakover voltages. We present these findings using experimental measurements and numerical simulations. C1 USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Shah, PB (reprint author), USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. NR 12 TC 5 Z9 5 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-8993 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD NOV PY 2002 VL 17 IS 6 BP 1073 EP 1079 DI 10.1109/TPEL.2002.805591 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 715AV UT WOS:000184949100026 ER PT J AU Sliney, DH AF Sliney, DH TI How light reaches the eye and its components SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article; Proceedings Paper CT 22nd Annual Conference of the American-College-of-Toxicology CY NOV 04-08, 2001 CL WASHINGTON, D.C. SP American Coll Toxicol DE lens; phototoxicity; retina; sunlight; ultraviolet ID ULTRAVIOLET-RADIATION; UV-RADIATION; SENSITIVITY; DAMAGE; LENS AB The human eye is exquisitely sensitive to light (i.e., visible radiant energy), and when dark-adapted, the retina can detect a few photons of blue-green light. It is therefore not at all surprising that ocular tissues are also more vulnerable to ultraviolet (UV) and light damage than the skin. For this reason, humans have evolved with certain anatomical, physiological, and behavioral traits that protect this critical organ from the UV damage that would otherwise be certain from the intense bath of overhead solar ultraviolet radiation (UVR) when we are outdoors during daylight. For example, the UV exposure threshold dose for photokeratitis ("welders' flash" or "snow blindness")-if measured as failing on a horizontal ground surface-would be reached in less than 10 minutes around midday in the summer sun. There are three critical ocular structures that could be affected by UV exposure: the cornea, the lens, and the retina. The cornea transmits radiant energy only at 295 out and above. The crystalline lens absorbs almost all incident energy to wavelengths of nearly 400 run. In youth, a very small amount of UV-A reaches the retina, but the lens becomes more absorbing with age. Thus there are intraocular filters that effectively filter different parts of the UV spectrum and allow only of the order of 1% or less to actually reach the retina. Nevertheless, this small fraction of energy-if phototoxic-could still be of concern. Finally, oblique rays entering the eye from the temporal side, can actually reach the equatorial (germinative) area of the lens. C1 USA, Ctr Hlth Promot & Prevent Med, MCHB TS OLO, Aberdeen Proving Ground, MD 21010 USA. RP Sliney, DH (reprint author), USA, Ctr Hlth Promot & Prevent Med, MCHB TS OLO, Aberdeen Proving Ground, MD 21010 USA. NR 52 TC 72 Z9 74 U1 0 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD NOV-DEC PY 2002 VL 21 IS 6 BP 501 EP 509 DI 10.1080/10915810290169927 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 631LK UT WOS:000180169100008 PM 12537646 ER PT J AU Miltner, RS AF Miltner, RS TI More than support: Nursing interventions provided to women in labor SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Article DE intrapartum nursing care; labor support; observational data collection; process of care; quality of care ID NURSES AB Objective: To describe the type and quantity of interventions provided to women in the first stage of labor. Design: Descriptive, observational. Setting: An intrapartum nursing unit in a Pacific Northwest medical center. Participants: Participants were 24 registered nurses employed on the intrapartum nursing unit and 75 women in labor with singleton pregnancies at 36 weeks or more gestation. Seventy-five 2-hour episodes of care that included one registered nurse assigned to a woman in labor were the units of analysis. Main Outcome Measures: Observed surveillance, indirect care, and supportive care interventions recorded during the episode of care during the first stage of labor. Results: Nurses spent an average of 58.9% of the observed time in direct or indirect care of the study patient and provided an average of 169.9 interventions. Nurses spent 31.5% of the observed time providing at least one supportive care intervention with or without a simultaneous surveillance and/or indirect care intervention. Conclusion: Nurses provided supportive care more frequently than previous work sampling studies have suggested. This supportive care was frequently done in conjunction with other, more technical nursing care interventions. Integration of supportive care with other direct and indirect care interventions may offer the best model for providing high-quality intrapartum nursing care. C1 Walter Reed Army Med Ctr, Dept Nursing, Washington, DC 20307 USA. RP Miltner, RS (reprint author), 1905 Ridgewood Rd, Hanover, MD 21076 USA. OI Miltner, Rebecca/0000-0002-4653-0328 NR 22 TC 16 Z9 16 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0884-2175 J9 JOGNN JI JOGNN PD NOV-DEC PY 2002 VL 31 IS 6 BP 753 EP 761 DI 10.1177/0884217502239214 PG 9 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA 619JT UT WOS:000179473400018 PM 12465872 ER PT J AU Fourcroy, JL AF Fourcroy, JL TI Andrology lab corner: A short course on the food and drug administration: What you should know SO JOURNAL OF ANDROLOGY LA English DT Article C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Washington, DC USA. Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. RP Fourcroy, JL (reprint author), 6310 Swords Way, Bethesda, MD 20817 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ANDROLOGY, INC PI LAWRENCE PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 USA SN 0196-3635 J9 J ANDROL JI J. Androl. PD NOV-DEC PY 2002 VL 23 IS 6 BP 754 EP 756 PG 3 WC Andrology SC Endocrinology & Metabolism GA 614GJ UT WOS:000179179700004 PM 12399516 ER PT J AU Leamy, MJ Wasfy, TM AF Leamy, MJ Wasfy, TM TI Analysis of belt-drive mechanics using a creep-rate-dependent friction law SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article ID SYSTEMS; VIBRATION; SLIP AB An analysis of the frictional mechanics of a steadily rotating belt drive is carried out using a physically appropriate creep-rate-dependent friction law. Unlike in belt-drive mechanics analyzed using a Coulomb friction law, the current analysis predicts no adhesion zones in the belt-pulley contact region. Regardless of this finding, for the limiting case of a creep-rate law approaching a Coulomb law, all predicted response quantities (including the extent of belt creep on each pulley) approach those predicted by the Coulomb law analysis. Depending on a slope parameter governing the creep-rate profile, one or two sliding zones exist on each pulley, which together span the belt-pulley contact region. Closed-form expressions are obtained for the tension distribution, the sliding-zone arc magnitudes, and the frictional and normal forces per unit length exerted on the belt. A sample two-pulley belt drive is analyzed further to determine its pulley angular velocity ratio and belt-span tensions. Results from this analysis are compared to a dynamic finite element solution of the same belt drive. Excellent agreement in predicted results is found. Due to the presence of arbitrarily large system rotations and a numerically friendly friction law, the analytical solution presented herein is recommended as a convenient comparison test case for validating friction-enabled dynamic finite element schemes. C1 US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. Adv Sci & Automat Corp, Hampton, VA 23666 USA. RP Leamy, MJ (reprint author), US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. NR 24 TC 17 Z9 17 U1 0 U2 4 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD NOV PY 2002 VL 69 IS 6 BP 763 EP 771 DI 10.1115/1.1488663 PG 9 WC Mechanics SC Mechanics GA 613WF UT WOS:000179153900006 ER PT J AU Motayed, A Davydov, AV Bendersky, LA Wood, MC Derenge, MA Wang, DF Jones, KA Mohammad, SN AF Motayed, A Davydov, AV Bendersky, LA Wood, MC Derenge, MA Wang, DF Jones, KA Mohammad, SN TI High-transparency Ni/Au bilayer contacts to n-type GaN SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID P-TYPE GAN; RESISTANCE OHMIC CONTACTS; INDIUM TIN OXIDE; TRANSISTOR; DIODES AB A unique metallization scheme has been developed for obtaining both Schottky and low-resistance Ohmic contacts to n-GaN. It has been demonstrated that the same metallization can be used to make both Schottky and Ohmic contacts to n-GaN using a Ni/Au bilayer composite with Ni in contact to GaN. Using this metallization, contacts with a specific contact resistivity, rho(s), as low as 6.9x10(-6) Omega cm(2) for a doping level of 5.0x10(17) cm(-3) was obtained after annealing the sample for 10 s at 800 degreesC in a rapid thermal annealer. The presence of only (111)Au and (111)Ni peaks in the x-ray diffraction (XRD) pattern of as-deposited samples indicates that both metals participate to form epitaxial or highly textured layers on the basal GaN plane. When the contact layer is annealed, Au and Ni react with GaN creating interfacial phases. Both XRD and transmission electron microscopy confirm that Ni3Ga and Ni2Ga3 intermetallic phases together with Au and Ni based face-centered-cubic solid solutions, are formed during annealing. The high optical transmission achieved (in the range of 400-700 nm) through this contact after annealing suggests that it is, indeed, very useful for electro-optic device applications. The contacts also demonstrate exceptional thermal stability. Experimental data suggest that the formation of interfacial phases with a low work function is responsible for the low contact resistance of the system. The Ni-Au layer forms a robust composite enabling the contacts to have high-temperature applications. Unlike the Ni/Au Ohmic contact, the Ni/Au Schottky contact to n-GaN has a relatively large barrier height. Improved material quality and Schottky contact technology are needed to improve upon the reverse breakdown voltage. (C) 2002 American Institute of Physics. C1 Howard Univ, Dept Elect Engn, Washington, DC 20059 USA. USA, Res Lab, Adelphi, MD 20783 USA. Natl Inst Stand & Technol, Div Met, Gaithersburg, MD 20899 USA. RP Mohammad, SN (reprint author), Howard Univ, Dept Elect Engn, 2300 6th St NW, Washington, DC 20059 USA. RI Davydov, Albert/F-7773-2010 OI Davydov, Albert/0000-0003-4512-2311 NR 25 TC 23 Z9 24 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 2002 VL 92 IS 9 BP 5218 EP 5227 DI 10.1063/1.1509109 PG 10 WC Physics, Applied SC Physics GA 607AA UT WOS:000178767200055 ER PT J AU Espy, MJ Cockerill, FR Meyer, RF Bowen, MD Poland, GA Hadfield, TL Smith, TF AF Espy, MJ Cockerill, FR Meyer, RF Bowen, MD Poland, GA Hadfield, TL Smith, TF TI Detection of smallpox virus DNA by lightcycler PCR (vol 40, pg 1985, 2002) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction C1 Mayo Clin & Mayo Fdn, Div Clin Microbiol, Rochester, MN 55905 USA. Mayo Clin & Mayo Fdn, Div Infect Dis, Rochester, MN 55905 USA. Mayo Clin & Mayo Fdn, Div Gen Internal Med, Rochester, MN 55905 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Walter Reed Army Med Ctr, Armed Forces Inst Pathol, Washington, DC 20307 USA. RP Espy, MJ (reprint author), Mayo Clin & Mayo Fdn, Div Clin Microbiol, 200 1st St SW, Rochester, MN 55905 USA. RI sebastianovitsch, stepan/G-8507-2013 NR 1 TC 0 Z9 1 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2002 VL 40 IS 11 BP 4405 EP 4405 DI 10.1128/JCM.40.11.4405.2002 PG 1 WC Microbiology SC Microbiology GA 612BH UT WOS:000179053200103 ER PT J AU Mayoral, JL Rubal, BJ AF Mayoral, JL Rubal, BJ TI Unusual sonographic finding in a patient with late recurrence of a perianal fistula SO JOURNAL OF CLINICAL ULTRASOUND LA English DT Article DE ultrasonography; perianal abscess; fistula in ano; perianal ultrasonography; portable ultrasound scanner ID IN-ANO; ANAL ENDOSONOGRAPHY; CLASSIFICATION; MANAGEMENT; SURGERY AB We describe a case of late recurrence of a perianal fistula in a 51-year-old man with a 4.5-year history of recurrent perianal fistulas and abscesses. This was the fourth recurrence he had experienced; at each occurrence, he had undergone various examinations, including sigmoidoscopy, anoscopy, barium enema, fistulography, probe exploration, instillation of hydrogen peroxide, and/or sonography, and he had also undergone surgery. At our examination, trans-perineal sonography with a portable ultrasound scanner revealed an echogenic linear structure within the fistulous tract. Under endoanal sonographic guidance, surgery was performed, and a tan solid cylindrical structure longer than 2 cm was removed. Histopathologic examination revealed stratified squamous epithelium and soft tissue with substantial fibrosis and mild chronic inflammation, findings consistent with the characteristics of a remnant cast from a previous fistulous tract. Our findings suggest that some patients may benefit from relatively inexpensive sonographic examination with appropriate transducers. (C) 2002 Wiley Periodicals, Inc. C1 Brooke Army Med Ctr, MCHE MDC Dept Med, Ft Sam Houston, TX 78234 USA. Colon & Rectal Surg Associates San Antonio, San Antonio, TX 78229 USA. RP Rubal, BJ (reprint author), Brooke Army Med Ctr, MCHE MDC Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 18 TC 0 Z9 0 U1 1 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0091-2751 J9 J CLIN ULTRASOUND JI J. Clin. Ultrasound PD NOV-DEC PY 2002 VL 30 IS 9 BP 557 EP 561 DI 10.1002/jcu.10113 PG 5 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 608YL UT WOS:000178875500008 PM 12404523 ER PT J AU Kennedy, RH Hains, JJ AF Kennedy, RH Hains, JJ TI Limnological assessment of Verkhne Viiskii Reservoir, Russian Federation SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID NORTHWEST-TERRITORIES CANADA; CHEMICAL LIMNOLOGY; LAKES AB Verkhne Viiskii Reservoir (surface area = 6.0 km(2); volume = 36.0 hm(3)), one of two water supply reservoirs for the City of Nizhnii Tagil, is located in a forested watershed (drainage area = 272 km(2)) in the Ural Mountain region of the Russian Federation. This study, conducted in August 1999, provides a benchmark limnological assessment against which to gauge future change. While currently meeting local water quality requirements for drinking water sources, the reservoir exhibits moderately eutrophic characteristics, including elevated epilimnetic nutrient (total P = 0.048-0.115 mg L-1; total N = 0.421-0.508 mg L-1) and chlorophyll (4-8.4 mug L-1) concentrations, and a high rate of hypolimnetic oxygen depletion (4.07 g m(-3) mo(-1)). C1 USA, Engineer Res & Dev Ctr, Environm Ctr, Vicksburg, MS 39180 USA. RP Kennedy, RH (reprint author), USA, Engineer Res & Dev Ctr, Environm Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 19 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD NOV-DEC PY 2002 VL 31 IS 6 BP 2111 EP 2115 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA 662NH UT WOS:000181953300040 PM 12469863 ER PT J AU Adams, BJ Byrd, JE AF Adams, BJ Byrd, JE TI Interobserver variation of selected postcranial skeletal measurements SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT 53rd Annual Meeting of the American-Academy-of-Forensic-Sciences CY FEB 19-24, 2001 CL SEATTLE, WASHINGTON SP Amer Acad Forens Sci DE forensic science; interobserver variation; osteometrics; skeletal measurements; validity; reliability; human osteology; forensic anthropology ID ANTHROPOMETRY; RELIABILITY; TIBIA AB Osteometric data are of great importance for analytical purposes in the field of forensic anthropology, and it is critical that interobserver concordance is high in order for the results of these analyses to be reliable. Significant interobserver variation of skeletal measurements is cause for concern since it may result in conflicting conclusions. The range of interobserver variation of selected posteranial measurements is addressed. Thirteen standard measurements familiar to most forensic anthropologists were examined, as well as nine nonstandard measurements that were unfamiliar to most participants in the study. Sixty-eight individuals participated in the study, the majority of whom considered themselves to be forensic anthropologists with various levels of experience. In general, interobserver variation of the tested standard posteranial measurements was found to be minimal, with the exception of pubis length and subtrochanteric femur measurements. The difficulties that can lead to measurement error are discussed and possible solutions are recommended. C1 USA, CILHI, Hickam AFB, HI 96853 USA. RP Adams, BJ (reprint author), USA, CILHI, 310 Worchester Ave, Hickam AFB, HI 96853 USA. NR 19 TC 25 Z9 25 U1 2 U2 8 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD NOV PY 2002 VL 47 IS 6 BP 1193 EP 1202 PG 10 WC Medicine, Legal SC Legal Medicine GA 613BM UT WOS:000179111100001 PM 12455639 ER PT J AU Moore, CE Davis, BD Leney, MD AF Moore, CE Davis, BD Leney, MD TI Analysis of pilot-related equipment and archaeological strategy in the recovery of aircrew losses from the Vietnam war SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; forensic anthropology; forensic archaeology; aircraft crash; life-support equipment; human remains; US Army Central Identification Laboratory; Hawaii ID HUMAN REMAINS; SOFT-TISSUE; DEATH; DECOMPOSITION; ARTIFACTS AB Determining the location and distribution of cockpit and aircrew-relatcol equipment within the wider debris field of a military aircraft crash site is an essential first step in planning and executing the recovery of missing aircrew members presumed still to be on the site. Understanding the spatial relationship of these materials improves the likelihood of finding and recovering the remains of the aircrew during die excavation of an aircraft crash site. Since the greater portion of these unaccounted for crew members were involved in aircraft with single-seat cockpits or cockpits with two or three seats in tandem, pre-analysis of the debris pattern may be more-or-less straight fonward. Larger, multiple-personnel aircraft, on the other hand, create a potentially more complex analytical situation given the aircrew's greater freedom of movement within the aircraft. Nevertheless, the same fundamental principles apply and, indeed, have been successfully so for some time in the civilian arena. But older aircraft crash sites, i.e., those dating to World War It, Korea, or the Vietnam conflict, have been and still are undergoing taphonomic processes that progressively alter these relationships. The following will illustrate that exchange of information between the anthropologist/archacologist and the life-support analyst is required to maximize the effectiveness of field recovery and demonstrates the relationship between the recovery of life-support equipment and human remains and the effect that aircraft type has on this relationship. C1 USA, Cent Identificat Lab, Hickam AFB, HI 96853 USA. Naga Res Grp, Honolulu, HI USA. RP Moore, CE (reprint author), USA, Cent Identificat Lab, 310 Worchester Ave, Hickam AFB, HI 96853 USA. NR 18 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD NOV PY 2002 VL 47 IS 6 BP 1210 EP 1214 PG 5 WC Medicine, Legal SC Legal Medicine GA 613BM UT WOS:000179111100003 PM 12455641 ER PT J AU Mulhall, BP Ong, JP Younossi, ZM AF Mulhall, BP Ong, JP Younossi, ZM TI Non-alcoholic fatty liver disease: An overview SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Review DE fatty liver; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis ID CHRONIC HEPATITIS-C; NONALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; CRYPTOGENIC CIRRHOSIS; PARENTERAL-NUTRITION; OVERWEIGHT PATIENTS; JEJUNOILEAL BYPASS; METABOLIC SYNDROME; CLINICAL-FEATURES; OBESE PATIENTS AB Non-alcoholic fatty liver disease (NAFL) includes a spectrum of clinicopathological conditions with increasing prevalence in the developed world. Although steatosis alone seems to have a benign course, those patients with the diagnosis of non-alcoholic steatohepatitis (NASH) can have a progressive course. Additionally, there is now evolving, indirect evidence that some of the patients with cryptogenic cirrhosis may be the result of 'burned-out' NASH. Although NAFL and NASH are associated with insulin-resistance syndrome, some patients with NAFL may have no obvious risk factors. Despite preliminary data from a number of pilot studies, no established therapies can be offered to patients with NASH. Over the next few years, a number of exciting research projects dealing with the epidemiology as well as the pathogenesis of NAFL are expected to be completed. It is anticipated that, through a better understanding of NAFL, more effective treatment protocols can be developed targeting only those patients with NASH that are at the highest risk for progression to cirrhosis and liver failure. (C) 2002 Blackwell Publishing Asia Pty Ltd. C1 Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA. Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. RP Younossi, ZM (reprint author), Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, 3300 Gallows Rd, Falls Church, VA 22042 USA. NR 94 TC 113 Z9 118 U1 2 U2 11 PU BLACKWELL PUBLISHING ASIA PI CARLTON PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA SN 0815-9319 J9 J GASTROEN HEPATOL JI J. Gastroenterol. Hepatol. PD NOV PY 2002 VL 17 IS 11 BP 1136 EP 1143 DI 10.1046/j.1440-1746.2002.02881.x PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 611TW UT WOS:000179034700002 PM 12453271 ER PT J AU Satava, RM AF Satava, RM TI The bio-intelligence age: Surgery after the information age SO JOURNAL OF GASTROINTESTINAL SURGERY LA English DT Article; Proceedings Paper CT 43rd Annual Meeting of the Society-for-Surgery-of-the-Alimentary-Tract CY MAY 19-22, 2002 CL SAN FRANCISCO, CALIFORNIA SP Soc Surg Alimentary Tract C1 Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA. USA, Mil Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Satava, RM (reprint author), Univ Washington, Med Ctr, Dept Surg, Rm 430,1959 NE Pacific St, Seattle, WA 98195 USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1091-255X J9 J GASTROINTEST SURG JI J. Gastrointest. Surg. PD NOV-DEC PY 2002 VL 6 IS 6 BP 795 EP 799 AR PII S1091-255X(02)00055-0 DI 10.1016/S1091-255X(02)00055-0 PG 5 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 641TR UT WOS:000180763100002 PM 12504216 ER PT J AU Arcone, SA Prentice, ML Delaney, AJ AF Arcone, SA Prentice, ML Delaney, AJ TI Stratigraphic profiling with ground-penetrating radar in permafrost: A review of possible analogs for Mars SO JOURNAL OF GEOPHYSICAL RESEARCH-PLANETS LA English DT Article DE ground-penetrating radar; permafrost ID TRANSANTARCTIC MOUNTAINS; GLACIAL HISTORY; DRY VALLEYS; ANTARCTICA; LANDSCAPE; ICE AB [1] We review our past and ongoing use of ground-penetrating radar to investigate permafrost in Alaska and in the Dry Valleys of Antarctica. The results may be relevant to radar efforts on Mars because of arid conditions and the presence of ice. The pulses were centered at 50, 100, and 400 MHz. We interpret profiles from two sites in the eastern Taylor Valley to show glaciolacustrine and glaciofluvial stratigraphy. The maximum depth of stratigraphy profiled there was about 33 m. Near Fairbanks, Alaska, the depth of penetration at 50 MHz was near 80 m in marginally frozen and stratified alluvial sands. At the Fairbanks sites, supplementary drilling was required to differentiate between reflections from conductive bedrock, a graphitic schist, and those from the water table at depths of 20-25 m. At a site on the North Slope of Alaska, we profiled present and remnant freezing fronts in an alluvial floodplain. The relative permittivity at most sites ranged between about 4 and 5.5, which is consistent with dry conditions, the mineralogy, and low ice content. Weak interface reflectivity or the lack of further interfaces may have limited the interpretation of maximum penetration where no water table was present because signal absorption should have been low and scarce diffractions imply that scattering was weak. The interface reflectivities beneath Taylor Valley may be a function of only density contrasts, since free water, and possibly ice, is absent. C1 USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, Hanover, NH 03755 USA. Univ New Hampshire, Climate Change Res Ctr, Durham, NH 03824 USA. RP Arcone, SA (reprint author), USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, 72 Lyme Rd, Hanover, NH 03755 USA. NR 31 TC 25 Z9 25 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-PLANET JI J. Geophys. Res.-Planets PD NOV PY 2002 VL 107 IS E11 AR 5108 DI 10.1029/2002JE001906 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 639RQ UT WOS:000180643400019 ER PT J AU Marshall, WJ AF Marshall, WJ TI Determining source size from diode laser systems SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser safety; ANSI Z136; laser standard; maximum permissible exposure; MPE; apparent angular subtense; laser source ID SAFETY AB Although hazard classification is performed at predefined distances, the maximum permissible exposure (MPE) for extended-source diode lasers decreases as the distance from the laser increases. The MPE depends on the apparent angular subtense of the source, which is simply the magnified image of the emitting diode. Small diameter beams require special consideration. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Marshall, WJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. NR 16 TC 3 Z9 3 U1 0 U2 2 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD NOV PY 2002 VL 14 IS 4 BP 252 EP 259 DI 10.2351/1.1514238 PG 8 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 615PE UT WOS:000179254500009 ER PT J AU Sliney, DH Lund, DJ Marshall, WJ AF Sliney, DH Lund, DJ Marshall, WJ TI Visible and invisible laser radiation - problems in laser safety terminology SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser; visibility; class 2; aversion response AB The spectral band between 400 and 700 nm is termed "visible" in laser safety standards, this is not the full extent of the visible spectrum. Light, or visible radiation, is that which is perceived by the human eye, and the spectral bandwidth for vision is really larger, extending into what some refer to as ultraviolet and infrared. This is important to recognize when speaking of visual effects such as after-images and glare. Several important questions arise with regard to this issue. The 400-700 nm spectral band was initially established as the extent of the spectral range for class 2 lasers, but should this spectral band be reconsidered? Indeed what laser wavelengths should be considered visible and what should be considered "invisible?". C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. USA, Med Res Detachment, Brooks AFB, TX 78235 USA. RP Sliney, DH (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. NR 22 TC 0 Z9 0 U1 1 U2 3 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD NOV PY 2002 VL 14 IS 4 BP 260 EP 263 DI 10.2351/1.1514223 PG 4 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 615PE UT WOS:000179254500010 ER PT J AU Rodriguez, S Munoz, VB Esquivel, EV Murr, LE Rupert, NL AF Rodriguez, S Munoz, VB Esquivel, EV Murr, LE Rupert, NL TI Microstructural characterization of TiB2 armor targets SO JOURNAL OF MATERIALS SCIENCE LETTERS LA English DT Article ID INTERFACE DEFEAT; CERAMIC TARGETS; STRENGTH C1 Univ Texas, Dept Met & Mat Engn, El Paso, TX 79968 USA. USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rodriguez, S (reprint author), Univ Texas, Dept Met & Mat Engn, El Paso, TX 79968 USA. NR 14 TC 8 Z9 8 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0261-8028 J9 J MATER SCI LETT JI J. Mater. Sci. Lett. PD NOV 1 PY 2002 VL 21 IS 21 BP 1661 EP 1666 DI 10.1023/A:1020868524652 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 609DA UT WOS:000178886300008 ER PT J AU Jolivet, RR AF Jolivet, RR TI Early-onset neonatal group B streptococcal infection: 2002 guidelines for prevention SO JOURNAL OF MIDWIFERY & WOMENS HEALTH LA English DT Article ID INTRAPARTUM CHEMOPROPHYLAXIS; RISK-FACTORS; DISEASE; PREGNANCY; AMPICILLIN; SUSCEPTIBILITY; COLONIZATION; PROPHYLAXIS; BACTERIURIA; MENINGITIS AB In 1996, the Centers for Disease Control and Prevention (CDC) and relevant professional organizations jointly released guidelines for prevention of early-onset neonatal group B streptococcal infections. The guidelines recommended that all obstetric providers and institutions providing intrapartum services follow one of two strategies. This year, on the basis of multistate surveillance data collected since prevention strategies were initiated, the CDC has released revised prevention recommendations. This article reviews the new guidelines and discusses clinical implications for practice in a variety of settings. (C) 2002 by the American College of Nurse-Midwives. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Jolivet, RR (reprint author), 9410 Wire Ave, Silver Spring, MD 20901 USA. NR 60 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1526-9523 J9 J MIDWIFERY WOM HEAL JI J. Midwifery Women Health PD NOV-DEC PY 2002 VL 47 IS 6 BP 435 EP 446 AR PII S1526-9523(02)00348-3 DI 10.1016/S1526-9523(02)00348-3 PG 12 WC Nursing SC Nursing GA 620PR UT WOS:000179542200006 PM 12484665 ER PT J AU Keesee, SM Baty, DL Cameron, SM Lefler, TB Morris, WJ AF Keesee, SM Baty, DL Cameron, SM Lefler, TB Morris, WJ TI A technique for achieving prerestorative minor tooth movement with orthodontic separators SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB This article describes 2 patient treatments in which a simple technique was used to realign teeth before restorative procedures. Elastic separators were used to tip the desired tooth into its original position. This restored a normal crown contour and improved the tooth's long-axis alignment. The procedure is simple and inexpensive, and treatment time relatively quick compared with other orthodontic procedures. C1 USA, Dent Activ, Tingay Dent Clin, Prosthodont Residency Program, Ft Gordon, GA 30905 USA. USA, Dent Activ, Tingay Dent Clin, Orthodont Serv, Ft Gordon, GA 30905 USA. RP Cameron, SM (reprint author), USA, Dent Activ, Tingay Dent Clin, Prosthodont Residency Program, Ft Gordon, GA 30905 USA. OI Baty, Daniel/0000-0001-8443-4444 NR 5 TC 4 Z9 5 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD NOV PY 2002 VL 88 IS 5 BP 544 EP 547 DI 10.1067/mpr.2002.129336 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 628QX UT WOS:000180008800015 PM 12474007 ER PT J AU Warber, JP Tharion, WJ Patton, JF Champagne, CM Mitotti, P Lieberman, HR AF Warber, JP Tharion, WJ Patton, JF Champagne, CM Mitotti, P Lieberman, HR TI The effect of creatine monohydrate supplementation multiple bench on obstacle course and press performance SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE sport nutrition; dietary supplementation; ergogenic aids; exercise training ID PHYSICAL PERFORMANCE; MUSCULAR STRENGTH; BODY-COMPOSITION; REPEATED BOUTS; EXERCISE; MUSCLE; INGESTION; HUMANS; INTERMITTENT; SINGLE AB Dietary creatine (Cr) supplementation has been shown to enhance muscular strength and endurance. This study determined the effects of Cr supplementation on performance of military training tasks. Two groups (Cr and placebo [P1]) of 13 male soldiers each performed 3 consecutive military obstacle course runs (similar to3 minutes over 7 obstacles with a 2-minute rest between runs) followed by a rifle marksmanship task on 3 occasions (T-1, T-2, and T-3), each separated by 5 days. They also completed a bench press protocol (5 sets to failure at 70% of 1 repetition maximum) and answered the Profile of Mood States questionnaire during each test session. Testing was done 3 times. No supplementation was given before T-1. Supplementation was provided using sports bars, with both groups receiving P1 bars between T-1 and T-2,whereas from T-2 to T-3 the Cr group consumed 24 g per day of Cr monohydrate in sports bars and the PI group consumed an equal amount (kilocalories) of PI sports bars. Creatine usage resulted in a significant (14%) increase in total bench press repetitions (p less than or equal to 0.05), but no difference between groups in obstacle course run times for the 3 runs from T-2 to T-3. Marksmanship or mood was not affected by Cr supplementation. An increase of 1.4 kg in body mass (p less than or equal to 0.005) and a 0.5% decrease in percent body fat (p less than or equal to 0.05) were observed after Cr ingestion. Creatine supplementation over 5 days improved performance during a controlled strength test but did not significantly improve military obstacle course performance. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. M&M Mars Inc, Hackettstown, NJ 07840 USA. RP Tharion, WJ (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 39 TC 10 Z9 10 U1 1 U2 8 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2002 VL 16 IS 4 BP 500 EP 508 PG 9 WC Sport Sciences SC Sport Sciences GA 618GD UT WOS:000179409600003 PM 12423177 ER PT J AU Waldrep, DA AF Waldrep, DA TI Two cases of ADHD following GABHS infection: A PANDAS subgroup? SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Letter ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDERS; STREPTOCOCCAL INFECTIONS; AUTOIMMUNE C1 USA, Med Corps, Dept Psychiat, Walter Reed Army Med Ctr, Washington, DC 20250 USA. RP Waldrep, DA (reprint author), USA, Med Corps, Dept Psychiat, Walter Reed Army Med Ctr, Washington, DC 20250 USA. NR 7 TC 13 Z9 13 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD NOV PY 2002 VL 41 IS 11 BP 1273 EP 1274 DI 10.1097/01.CHI.0000024857.60748.A8 PG 2 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA 607MW UT WOS:000178796200008 PM 12410069 ER PT J AU Smith, SB Libow, LF Elston, DM Bernert, RA Warschaw, KE AF Smith, SB Libow, LF Elston, DM Bernert, RA Warschaw, KE TI Gloves and socks syndrome: Early and late histopathologic features SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article; Proceedings Paper CT Summer Meeting of the American-Academy-of-Dermatology CY JUL 28-AUG 01, 2001 CL ANAHEIM, CALIFORNIA SP Amer Acad Dermatol ID PAPULAR-PURPURIC GLOVES; POLYMERASE-CHAIN-REACTION; PARVOVIRUS B19 INFECTION; VIRUS INFECTION; PETECHIAL GLOVE AB Background. Gloves and socks syndrome (GSS) is a recently described exanthem, most commonly caused by parvovirus B19. Objective: Our purpose was to describe both early and late histopathologic features of GSS. Methods: We performed histopathologic examination of biopsy specimens from a case of GSS and reviewed all the English-language literature reports of GSS to compare the reported histologic descriptions. Results: A total of 46 cases of GSS have been reported in the English-language literature. In 18 of those, the pathologic features were described. The histologic features of the current case evolved from a nonspecific superficial perivascular lymphocytic infiltrate to a vacuolar interface dermatitis with necrotic keratinocytes, erythrocyte extravasation, and a superficial perivascular and interstitial lymphocytic infiltrate. Conclusion: Early lesions of GSS show nonspecific features common to viral exanthems. The late features, of a fully evolved exanthem, demonstrate a vacuolar interface dermatitis with necrotic keratinocytes, a superficial perivascular and interstitial infiltrate, and dermal hemorrhage. These late pathologic features, together with the clinical appearance of GSS, may help distinguish it from other entities. C1 Brooke Army Med Ctr, Dept Dermatol, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Ft Sam Houston, TX USA. Mayo Clin, Scottsdale, AZ USA. RP Smith, SB (reprint author), Brooke Army Med Ctr, Dept Dermatol, San Antonio Uniformed Serv Hlth Educ Consortium, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 29 TC 17 Z9 17 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 2002 VL 47 IS 5 BP 749 EP 754 DI 10.1067/mjd.2002.124612 PG 6 WC Dermatology SC Dermatology GA 609FM UT WOS:000178893000015 PM 12399769 ER PT J AU Schwartz, J Norton, SA AF Schwartz, J Norton, SA TI Useful plants of dermatology. VI. The mayapple (Podophyllum) SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article C1 Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. Lake Erie Coll Osteopath Med, Erie, PA USA. RP Norton, SA (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 10 TC 6 Z9 7 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 2002 VL 47 IS 5 BP 774 EP 775 DI 10.1067/mjd.2002.125081 PG 2 WC Dermatology SC Dermatology GA 609FM UT WOS:000178893000019 PM 12399773 ER PT J AU Elston, DM AF Elston, DM TI Medical Pearl: Fluorescence microscopy of hematoxyhn-eosin-stained sections SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID LASER-SCANNING MICROSCOPY; ELASTIC FIBERS; FUNGAL AUTOFLUORESCENCE; SCAR TISSUE C1 Brooke Army Med Ctr, Dept Dermatol MCHE DD, Ft Sam Houston, TX 78234 USA. RP Elston, DM (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 20 TC 9 Z9 9 U1 0 U2 8 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 2002 VL 47 IS 5 BP 777 EP 779 DI 10.1067/mjd.2002.120623 PG 3 WC Dermatology SC Dermatology GA 609FM UT WOS:000178893000021 PM 12399775 ER PT J AU Ding, MS Xu, K Jow, TR AF Ding, MS Xu, K Jow, TR TI Effects of tris(2,2,2-trifluoroethyl) phosphate as a flame-retarding cosolvent on physicochemical properties of electrolytes of LiPF6 in EC-PC-EMC of 3 : 3 : 4 weight ratios SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID LITHIUM BATTERIES; PROPYLENE CARBONATE; ETHYLENE CARBONATE; BINARY CARBONATES; PHASE-DIAGRAMS; CONDUCTIVITY; TEMPERATURE; GRAPHITE; SOLVENT; SALTS AB We synthesized tris(2,2,2-trifluoroethyl) phosphate (TFP) as a flame-retarding solvent, measured its properties, and studied its effects on the physicochemical properties of the electrolytes LiPF6 in ethylene carbonate-propylene carbonate-ethyl methyl carbonate (EC-PC-EMC) of 3: 3: 4 weight ratios. These properties included dielectric constant of the solvent, flammability and conductivity of the electrolytes, and viscosity of the solvent and the electrolytes. The viscosity was studied indirectly through measuring glass transition (T-g) and boiling temperatures of the solvents and electrolytes. We found that TFP reduced the flammability and vapor pressure of the carbonate-based electrolytes, but lowered their conductivity by raising their viscosities and by lowering the dielectric constant of their solvents. Furthermore, this fall of conductivity with TFP content was almost linear, the rate of fall being higher at lower temperatures and higher LiPF6 concentrations. We compared the conductivity of this system with that of LiPF6 in EMC-EC, and found a number of important similarities and differences. We also calculated vanishing mobility temperature T-0 from fitting the Vogel-Tamman-Fulcher equation to the conductivity/temperature data and found it changed the same way as T-g did: it rose with TFP content and LiPF6 concentration. (C) 2002 The Electrochemical Society. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Ding, MS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Xu, Kang/C-6054-2013 NR 36 TC 37 Z9 38 U1 2 U2 9 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD NOV PY 2002 VL 149 IS 11 BP A1489 EP A1498 DI 10.1149/1.1513556 PG 10 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 604KV UT WOS:000178620700017 ER PT J AU Moul, JW AF Moul, JW TI Screening for prostate cancer in high risk populations - Comment SO JOURNAL OF UROLOGY LA English DT Editorial Material ID ANTIGEN C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA. Walter Reed Army Med Ctr, Rockville, MD USA. RP Moul, JW (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 2002 VL 168 IS 5 BP 1983 EP 1984 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 603LX UT WOS:000178562100020 ER PT J AU Powell, IJ Tangen, CM Miller, GJ Lowe, BA Haas, G Carroll, PR Osswald, MB White, RD Thompson, IM Crawford, ED AF Powell, IJ Tangen, CM Miller, GJ Lowe, BA Haas, G Carroll, PR Osswald, MB White, RD Thompson, IM Crawford, ED TI Neoadjuvant therapy before radical prostatectomy for clinical T3/T4 carcinoma of the prostate: 5-year followup, phase II Southwest Oncology Group study 9109 SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; prostatectomy; neoadjuvant therapy ID ANDROGEN DEPRIVATION; CANCER AB Purpose: Several investigators have examined the role of hormonal therapy before definitive local therapy for locally advanced prostate cancer to improve outcome. We evaluated the resectability rate and clinical response rate to 16 weeks of total androgen blockage therapy for clinically locally prostate cancer before radical prostatectomy, and progression-free survival in this multi-institutional study. Materials and Methods: Southwest Oncology Group 9109 was a phase II feasibility study designed to treat patients with clinical stage C prostate cancer (T3, T4, N0 and M0). Cases were classified by stage T3 versus T4 and bulky (greater than 4 cm.) versus nonbulky (or less 4 cm.) disease. The neoadjuvant agents used were goserelin and flutamide before radical prostatectomy. Results: A total of 62 patients were accrued to the study and 1 patient was ineligible. There were 2 protocol deviations and these patients refused to undergo prostatectomy after hormonal therapy. Four patients went off protocol treatment because they were not considered surgical candidates. The racial distribution was 72% white, 20% black, 7% Hispanic and 2% Asian. Clinical stage at diagnosis was T3 in 97% and T4 in 3% of cases. Of the patients 39% were diagnosed with bulky disease. Of the 61 eligible patients 55 (90%) underwent a prostatectomy. The 5-year progression-free survival estimate was 70% (24 of 61 cases failed) and the 5-year survival estimate was 90% (11 of 61 deaths). Most of the patients in this trial would have been considered inoperable and referred to radiation oncology. Conclusions: Neoadjuvant hormonal therapy followed by radical prostatectomy is reasonable and appropriate for clinical stage T3 prostate cancer. A progression-free and overall 5-year survival of 70% and 90%, respectively, compares favorably to Radiation Therapy Oncology Group neoadjuvant trial outcomes for this stage of prostate cancer. C1 Wayne State Univ, Med Ctr, Detroit, MI 48202 USA. SW Oncol Grp, Ctr Stat, Seattle, WA USA. Univ Colorado, Denver, CO 80202 USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. SUNY Syracuse, Syracuse, NY USA. San Francisco UCOP, San Francisco, CA USA. Univ Calif Davis, Sacramento, CA 95817 USA. Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, San Antonio, TX 78236 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RP Powell, IJ (reprint author), SW Oncol Grp, Operat Off, 14980 Omicron Dr, San Antonio, TX 78245 USA. FU NCI NIH HHS [CA32102, CA04919, CA13612, CA14028, CA16385, CA20319, CA22433, CA35090, CA35176, CA35178, CA38926, CA42777, CA46113, CA46441, CA58348, CA76132]; PHS HHS [76447] NR 11 TC 44 Z9 47 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 2002 VL 168 IS 5 BP 2016 EP 2019 DI 10.1097/01.ju.0000034315.18704.2b PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 603LX UT WOS:000178562100030 PM 12394698 ER PT J AU Scultetus, AH Villavicencio, JL Gillespie, DL Kao, TC Rich, NM AF Scultetus, AH Villavicencio, JL Gillespie, DL Kao, TC Rich, NM TI The pelvic venous syndromes: Analysis of our experience with 57 patients SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 14th Annual Meeting of the American-Venous-Forum CY FEB 21-24, 2002 CL LA JOLLA, CALIFORNIA SP Amer Venous Forum ID OVARIAN VEIN EMBOLIZATION; RANDOMIZED CONTROLLED TRIAL; CONGESTION SYNDROME; MEDROXYPROGESTERONE ACETATE; PAIN SYNDROME; VARICES; WOMEN; CT; VARICOSITIES; VARICOCELE AB Background. The pelvic venous syndromes comprise a group of poorly understood disorders of the pelvic and gonadal venous circulation. The objective of this paper was to review our experience with the pelvic venous syndromes and, in the light of the current literature, make management recommendations. Materials and Methods. Fifty-seven female patients (age range, 24 to 48 years; mean, 34 years) with symptoms of pelvic pain, dysuria, dysmenorrhea, dyspareunia, and the presence of vulval and pelvic varices were studied. Diagnosis included physical examination, Doppler scan, duplex ultrasound scan, computed tomography, magnetic resonance imaging, and retrograde cinevideoangiography. The symptoms were classified as: 1, mild (n = 15); 2, moderately severe (n = 19); and 3, severe (n = 23). Group I was treated with sclerotherapy/local excision of vulval varices. Group 2 had gonadal vein resection (GVR; n = 12) and sclerotherapy or gonadal vein coil embolization (GVE; n = 7) and sclerotherapy. Only the incompetent side was treated. Patients in group 3 with isolated hypogastric vein tributary reflux were treated either with hypogastric vein tributaries division (HVTD) or with embolization (HVTE) as the only procedure. Those with combined gonadal and hypogastric vein reflux were treated with HVTE followed by GVR. The follow-up period ranged from 2.5 to 24 years (mean GVR/HVTD, 12.4 years; mean GVE/HVTE, 2.3 years). Pain improvement was assessed with a visual analog scale and through mailed questionnaires (response rate, 100%). Patient results were classified as excellent (asymptomatic), moderate (mild discomfort), or no improvement. Results: In group 1, 12 patients had excellent results and three had moderate results. In group 2, 10 patients treated with GVR had excellent results, one had moderate results, and one had no improvement. Three patients treated with GVE were asymptomatic, and four had no improvement. In group 3, three patients treated with HVTD were asymptomatic and two had no improvement. Five patients treated with HVTE were asymptomatic, and one had no improvement. Of the 12 patients treated with HVTE and GVR, 10 were asymptomatic, one had moderate results, and one had no improvement. Conclusion: Local excision of vulval varices and sclerotherapy were sufficient in patients with mild symptoms. Gonadal vein excision produced better results than GVE. In patients with isolated hypogastric vein reflux, embolization was a better option than surgical treatment. GVR preceded by embolization of the incompetent tributaries of the internal iliac vein was indicated in patients with combined reflux and severe symptoms. Supplemental sclerotherapy of vulval varices is recommended after control of the intrapelvic reflux. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Walter Reed Army, Venous & Lymphat Teaching Clin, Bethesda, MD USA. Natl Naval Med Res Inst, Bethesda, MD USA. Walter Reed Army Med Ctr, Vasc Surg Serv, Dept Surg, Bethesda, MD USA. RP Villavicencio, JL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jvillavicencio@usuhs.mil OI Gillespie, David/0000-0002-4378-9465 NR 48 TC 39 Z9 51 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD NOV PY 2002 VL 36 IS 5 BP 881 EP 888 DI 10.1067/mva.2002.129114 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 615ZK UT WOS:000179277100003 PM 12422096 ER PT J AU Smith, JM AF Smith, JM TI Wave pressure gauge analysis with current SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE pressure gages; wave pressures; wave height; Washington; currents AB Bottom-mounted pressure gauges are used to measure waves in coastal inlets, where tidal currents are significant. Theoretically, neglect of the current in analysis of pressure data can lead to order-one errors in wave height estimates. Wave height is overestimated by neglecting flood current and underestimated by neglecting ebb current. A collocated wave buoy and bottom-mounted pressure gauge were deployed at Willapa Bay, Washington, to evaluate the significance of including current in pressure data analysis. Wave heights were overestimated by up to 20% if current was neglected. Larger current-induced errors in wave height were prevented by truncation of high-frequency energy to exclude pressure system noise. Truncation of the spectra leads to overestimates of mean wave period and underestimates of wave height. Adding a theoretical tail to the spectra reduces truncation errors. If current measurements are not available for pressure gauge analysis, reasonable results can be achieved by applying a conservative high-frequency cutoff and adding a theoretical tail. C1 USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Smith, JM (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 12 TC 6 Z9 6 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 2002 VL 128 IS 6 BP 271 EP 275 DI 10.1061/(ASCE)0733-950X(2002)128:6(271) PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 610VZ UT WOS:000178983400005 ER PT J AU Trespalacios, FC Taylor, AJ Agodoa, LY Abbott, KC AF Trespalacios, FC Taylor, AJ Agodoa, LY Abbott, KC TI Incident acute coronary syndromes in chronic dialysis patients in the United States SO KIDNEY INTERNATIONAL LA English DT Article DE cholesterol; angiotensin-converting enzyme inhibitors; beta blockers; aspirin; HMG-CoA reductase inhibitors; calcium channel blockers; USRDS; age; phosphorous; calcium; parathyroid hormone; blood pressure ID CHRONIC-HEMODIALYSIS PATIENTS; RISK-FACTORS; MYOCARDIAL-INFARCTION; PARATHYROID-HORMONE; PLAQUE MORPHOLOGY; MORTALITY RISK; FOLLOW-UP; CALCIFICATION; ASSOCIATION; TRANSPLANT AB Background. Patients on dialysis have a disproportionately high rate of cardiovascular disease (CVD). However, the incidence and risk factors for incident acute coronary syndromes (ACS) have not been previously assessed in dialysis patients. Methods. We analyzed the United States Renal Data System (USRDS) Dialysis Morbidity and Mortality Study (DMMS) Wave II in a historical cohort study of ACS. Data from 3374 patients who started dialysis in 1996 with valid follow-up times were available for analysis, censored at the time of renal transplantation and followed until March 2000. Cox regression analysis was used to model factors associated with time to first hospitalization for ACS (ICD9 code 410.x or 411.x) adjusted for comorbidities, demographic factors, baseline laboratory values, blood pressures and cholesterol levels, type of vascular access, dialysis adequacy, and cardioprotective medications (angiotensin-converting enzyme inhibitors, calcium channel blockers, HMG-CoA reductase inhibitors (statins), beta blockers, and aspirin). Follow-up was 2.19 +/- 1.14 years. Results. The incidence of ACS was 29/1000 person-years. Factors associated with ACS were older age, the extreme high and low ranges of serum cholesterol level, history of coronary heart disease (CHD), male gender, and diabetes. No cardioprotective medications including statins had a significant association with ACS in this study. However, medications known to reduce mortality after ACS were used in less than 50% of patients with known CHD at the start of the study, and statins were used in less than 10% of patients with CHD. Conclusions. Dialysis patients had similar risk factors for ACS compared to the general population. Cardioprotective medications were not associated with a significant benefit, possibly due to their striking underutilization in this at-risk population. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. NIDDKD, NIH, Bethesda, MD 20892 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 29 TC 66 Z9 67 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD NOV PY 2002 VL 62 IS 5 BP 1799 EP 1805 DI 10.1046/j.1523-1755.2002.00638.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 602BC UT WOS:000178484000042 PM 12371982 ER PT J AU Minyard, CM AF Minyard, CM TI Hell wouldn't stop: An oral history of the battle of Wake Island. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Mt Pleasant, MI USA. RP Minyard, CM (reprint author), USA, Mt Pleasant, MI USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2002 VL 127 IS 18 BP 104 EP 104 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 608ZN UT WOS:000178878100141 ER PT J AU Wolfenstine, J Campos, S AF Wolfenstine, J Campos, S TI Effect of Fe on the cycle life of Cu6Sn5 anodes SO MATERIALS LETTERS LA English DT Article DE iron; Li ion; batteries; capacity; anode; grain boundaries ID RECHARGEABLE LITHIUM BATTERIES; ION BATTERIES; SN; POWDERS; ALLOYS; DEFORMATION; INSERTION; ELECTRODE; NI3AL AB The addition of 10 wt.% Fe to a Cu6Sn5 alloy resulted in a significant improvement in the cycle lifetime of the alloy. The volumetric capacity of the Cu6Sn5-10 wt.% Fe material at 100 cycles is almost three times the theoretical capacity of graphite. Published by Elsevier Science B.V. C1 USA, Res Lab, AMSRL SE DC, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, AMSRL SE DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 24 TC 5 Z9 6 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD NOV PY 2002 VL 57 IS 1 BP 24 EP 27 AR PII S0167-577X(02)00692-4 DI 10.1016/S0167-577X(02)00692-4 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 614KB UT WOS:000179186600006 ER PT J AU Cheng, H Fang, SC Lavery, JE AF Cheng, H Fang, SC Lavery, JE TI Univariate cubic L-1 splines - A geometric programming approach SO MATHEMATICAL METHODS OF OPERATIONS RESEARCH LA English DT Article DE cubic L-1 spline; geometric programming; interpolation; spline function; univariate ID MULTISCALE INTERPOLATION AB Univariate cubic L-1 splines provide C-1-smooth, shape-preserving interpolation of arbitrary data, including data with abrupt changes in spacing and magnitude. The minimization principle for univariate cubic L-1 splines results in a nondifferentiable convex optimization problem. In order to provide theoretical treatment and to develop efficient algorithms, this problem is reformulated as a generalized geometric programming problem. A geometric dual with a linear objective function and convex quadratic constraints is derived. A linear system for dual to primal conversion is established. The results of computational experiments are presented. In the natural norm for this class of problems, namely, the L, norm of the second derivative, the geometric programming approach finds better solutions than the previously used discretization method. C1 N Carolina State Univ, Raleigh, NC 27695 USA. USA, Res Lab, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Cheng, H (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. NR 21 TC 15 Z9 16 U1 1 U2 2 PU PHYSICA-VERLAG GMBH & CO PI HEIDELBERG PA TIERGARTENSTRASSE 17, 69121 HEIDELBERG, GERMANY SN 1432-2994 J9 MATH METHOD OPER RES JI Math. Method Oper. Res. PD NOV PY 2002 VL 56 IS 2 BP 197 EP 229 PG 33 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA 620HB UT WOS:000179527000004 ER PT J AU Nindl, BC Leone, CD Tharion, WJ Johnson, RF Castellani, JW Patton, JF Montain, SJ AF Nindl, BC Leone, CD Tharion, WJ Johnson, RF Castellani, JW Patton, JF Montain, SJ TI Physical performance responses during 72 h of military operational stress SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE weight loss; overtraining; sleep deprivation; energy restriction; military personnel; occupational performance ID SLEEP-DEPRIVATION; PROLONGED EXERCISE; WEIGHT-LOSS; ACTIVE MEN; ENERGY; SOLDIERS; STRENGTH; WOMEN; MASS; WORK AB Purpose: To characterize the impact of prolonged work, underfeeding, and sleep deprivation (i.e., sustained operations; SUSOPS) on physical and occupational related performance during military operational stress. Methods: Ten male soldiers were tested on days I (D 1), 3 (D3), and 4 (D4) of a control and an experimental week that included prolonged physical work (total daily energy expenditure similar to4500 kcal.d(-1)), underfeeding (similar to1600 kcal.d(-1)), and sleep deprivation (similar to2 h.d(-1)). Body composition was measured with dual-energy x-ray absorptiometry (DEXA). Ballistic power was assessed by 30 repetitive squat jumps and bench-press throws. Military-relevant occupational performance was evaluated with a 10-min box lift, obstacle course, grenade throw, rifle marksmanship, and a 25-min wall-build task. Results: Fat-free mass (-2.3%) and fat mass (-7.3%) declined (P less than or equal to 0.05) during SUSOPS. Squat-jump mean power (-9%) and total work (- 15%) declined (P less than or equal to 0.05) during SUSOPS. Bench-press power output, grenade throw, and marksmanship for pop-up targets were not affected. Obstacle course and box-lift performances were lower (P less than or equal to 0.05) on D3 but showed some recovery on D4. Wall building was similar to25% lower (P less than or equal to 0.05) during SUSOPS. Conclusion: Decrements in performance during SUSOPS are primarily restricted to tasks that recruit muscles that are over-utilized without adequate recovery. General military skill tasks and occupational physical performance tasks are fairly well maintained. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. NR 34 TC 53 Z9 55 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2002 VL 34 IS 11 BP 1814 EP 1822 DI 10.1249/01.MSS.0000037093.39080.3E PG 9 WC Sport Sciences SC Sport Sciences GA 613ZB UT WOS:000179160700019 PM 12439088 ER PT J AU Reynolds, PC Calkins, M Bentley, T Popa, C AF Reynolds, PC Calkins, M Bentley, T Popa, C TI Improved anesthesia support of the forward surgical team: A proposed combination of drawover anesthesia and the life support for trauma and transport SO MILITARY MEDICINE LA English DT Article AB The Ohmeda Portable Anesthesia Complete is the apparatus available for delivery of general anesthesia in the forward surgical teams in the U.S. Army. The Life Support for Trauma and Transport is being field tested for use as a single patient critical care transport bed. An effective circuit was created which linked the currently fielded draw-over anesthesia machine with the patient ventilator (Impact 754 Eagle) mounted in the Life Support for Trauma and Transport, with bench testing indicating that the anesthesia levels were accurate and that it was a useful system for field resuscitation and surgery. Others should be able to utilize this information for the benefit of their patients in field environments, especially forward surgical teams and others working in austere health care locations. C1 SHAPE Healthcare Facil, B-7010 Casteau, Belgium. Walter Reed Army Inst Res, Dept Resuscitat Med, Silver Spring, MD 20910 USA. Walter Reed Army Med Ctr, Dept Crit Care Med, Washington, DC 20307 USA. RP Reynolds, PC (reprint author), SHAPE Healthcare Facil, Ave Oslo,Batiment 401, B-7010 Casteau, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2002 VL 167 IS 11 BP 889 EP 892 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 653EE UT WOS:000181421600006 PM 12448612 ER PT J AU Agazio, JB Pavlides, CC Lasome, CEM Flaherty, NJ Torrance, RJ AF Agazio, JB Pavlides, CC Lasome, CEM Flaherty, NJ Torrance, RJ TI Evaluation of a virtual reality simulator in sustainment training SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the Southern-Nursing-Research-Society CY FEB 01, 2001 CL BALTIMORE, MARYLAND SP SO Nursing Res Soc AB Is there a better way to train and prepare our health care personnel to function in a chemical biological environment while continuing to provide for patient care in a variety of healthcare settings? The purpose of this pilot work was to compare the effectiveness and user satisfaction of the Cath-Sim Intravenous Training System to the traditional IV arm model for teaching and achieving competence at IV insertion while in Mission-Oriented Protective Posture level 4 for Army medical personnel. Grounded in adult psychomotor learning principles and in an established evaluation model, participants were tested on both the traditional IV arm and Cath-Sim models and then allowed to practice on each model while at Mission-Oriented Protective Posture level 4. One week later, participants were again tested on both models. Outcome measures included (1) a computer-generated score sheet measuring time to success and criterion success/nonsuccess on the Cath-Sim; (2) time and success rating for IV insertion on the IV arm model; and (3) satisfaction evaluations completed by the participants. There were conflicting evaluation scores for recommending one model over the other. Participants felt that there was some benefit to each model depending on user, setting, and purpose. C1 Uniformed Serv Univ Hlth Sci, Sch Nursing, Silver Spring, MD 20910 USA. Walter Reed Army Med Ctr, Dept Nursing, Washington, DC 20307 USA. Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA. Henry M Jackson Fdn, Rockville, MD 20852 USA. RP Agazio, JB (reprint author), Uniformed Serv Univ Hlth Sci, Sch Nursing, 1335 Jones Bridge Rd,Suite 9-100, Silver Spring, MD 20910 USA. NR 2 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2002 VL 167 IS 11 BP 893 EP 897 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 653EE UT WOS:000181421600007 PM 12448613 ER PT J AU Chaffin, J Richter, P AF Chaffin, J Richter, P TI Making prevention of abuse and neglect through dental awareness green SO MILITARY MEDICINE LA English DT Article ID DOMESTIC VIOLENCE AB Family violence encompasses child, spouse, and elder abuse and neglect and is viewed as a serious public health threat in our society. Unfortunately, abuse and neglect are commonplace in our society and are not limited to the civilian sector. The military community mirrors the civilian sector in the prevalence of abuse and neglect. Traditionally, identification and intervention of suspected cases of abuse and neglect was thought to be the role of the medical provider. Reports that up to 94% of family violence injuries have head and neck components, which is the very site that dental providers focus their attention, justifies the need for dental involvement. The U.S. Army Dental Command's Health Promotion and Disease Prevention Program's newest initiative is a family violence awareness program called Prevention of Abuse and Neglect through Dental Awareness (P.A.N.D.A.). The program augments the Army Family Advocacy Program and gives dental-specific knowledge to our providers. The goals of this article are to describe the new program of the U.S. Army Dental Command that focuses on providing education and awareness to the dental community regarding family violence and to report the results of a survey that has been administered during the family violence training. More than 71% of individuals attending the P.A.N.D.A. training claimed to have previous training in family violence, whereas only 44% were knowledgeable about military regulations governing abuse and neglect. C1 USA, Dent Command, Ft Sam Houston, TX 78234 USA. RP Chaffin, J (reprint author), USA, Dent Command, 2050 Worth Rd,Suite 4, Ft Sam Houston, TX 78234 USA. NR 8 TC 2 Z9 2 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2002 VL 167 IS 11 BP 920 EP 922 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 653EE UT WOS:000181421600012 PM 12448618 ER PT J AU Earles, J Folen, RA Ma, M Kellar, M Geralde, R Dydek, G AF Earles, J Folen, RA Ma, M Kellar, M Geralde, R Dydek, G TI Clinical effectiveness of sustained-release bupropion and behavior therapy for tobacco dependence in a clinical setting SO MILITARY MEDICINE LA English DT Article ID SMOKING CESSATION; RANDOMIZED TRIAL; NICOTINE PATCH; INTERVENTIONS; QUIT AB Despite decades of public education, cigarette smoking remains a serious health problem. The treatment approach at Tripler Army Medical Center is a unique collaboration of family practice physicians and health psychologists providing combination therapy to patients attempting to quit smoking. This article discusses a program evaluation of the Tripler Army Medical Center smoking cessation program. Patients attempting to quit smoking were assisted with a combination of cognitive-behavioral group therapy and sustained-release bupropion hydrochloride. At 6 months postintervention, patients who attended the smoking cessation programs were contacted via telephone and asked to complete a survey regarding their smoking status. One hundred forty-four participants completed the survey. Thirty-five percent of all contacted attendees remained abstinent from smoking at 6 months after intervention. A significantly greater percentage of men quit than women. There were no significant differences of abstinence rates by any other demographic characteristic or smoking history variable. Family practice physicians and health psychologists providing a combination of pharmacological and group cognitive-behavior therapy for nicotine dependence are effective in promoting abstinence from smoking. C1 Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. Jackson State Univ, Community Hlth Program, Jackson, MS 39217 USA. USA, Hlth Clin, APO, AE 09182 USA. USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Earles, J (reprint author), Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. NR 20 TC 3 Z9 5 U1 2 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2002 VL 167 IS 11 BP 923 EP 925 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 653EE UT WOS:000181421600013 PM 12448619 ER PT J AU Likos, AM Neville, J Gaydos, JC AF Likos, AM Neville, J Gaydos, JC TI Influenza outbreak and response preparedness in the Air National Guard SO MILITARY MEDICINE LA English DT Article ID SURVEILLANCE; VIRUS AB A 1997 influenza outbreak with a high case fatality rate reminded public health officials of the serious nature of this disease. Civilian authorities worldwide have initiated planning in preparation for another pandemic, possibly of the magnitude observed in 1918. Military agencies have also begun pandemic preparation. However, planning for influenza outbreaks in the Air National Guard (ANG) has not received a high priority. Through interviews and document reviews, we examined the current policies and procedures of the ANG in relation to influenza surveillance, outbreak response, vaccination, and use of antiviral drugs. Deployment and demographic data were studied and indicated ANG populations were at risk for infection with and dissemination of novel influenza strains. Pandemic planning in the ANG must be given a higher priority, to include initiating laboratory-based surveillance, enhancing communication and coordination with other public health authorities, and considering the potential use of antiviral drugs. C1 Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. USAF, Inst Environm Safety & Occupat Hlth Risk Anal, Brooks AFB, TX 78235 USA. Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. RP Likos, AM (reprint author), 175th Med Squadron,175 Wing, Baltimore, MD 21220 USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2002 VL 167 IS 11 BP 929 EP 933 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 653EE UT WOS:000181421600015 PM 12448621 ER PT J AU Kaplan, KJ Burgess, JR Sandberg, GD Myers, CP Bigott, TR Greenspan, RB AF Kaplan, KJ Burgess, JR Sandberg, GD Myers, CP Bigott, TR Greenspan, RB TI Use of robotic Telepathology for frozen-section diagnosis: A retrospective trial of a telepathology system for intraoperative consultation SO MODERN PATHOLOGY LA English DT Article DE AFIP; diagnosis; frozen section; telepathology ID OF-VETERANS-AFFAIRS; SURGICAL PATHOLOGY; ACCURACY; EXPERIENCE; BIOPSIES; FEASIBILITY; RELIABILITY; MICROSCOPY; SPECIMENS AB Telepathology is the practice of digitizing histological or macroscopic images for transmission along telecommunication pathways for diagnosis, consultation, or continuing medical education. Previous studies have addressed static versus dynamic imaging in several specimen types with a wide variety of systems and communication pathways. The goal of this paper was to assess the validity of a Web-based telepathology system for frozen section consultation within the Army Medical Department. The system provides real-time, dynamic remote control of a robotic microscope over standard Internet connections. Oftentimes, a solo pathologist is called on to provide diagnostic services without the support of immediate second or expert consultation during an intraoperative consultation. The use of telepathology is attractive because it provides an opportunity for pathologists to obtain immediate consultation. For purposes of the study, 120 consecutive frozen section cases were diagnosed at a distance using the system. Intraobserver agreement between the telepathology diagnosis and glass slide diagnosis was observed. Diagnostic agreement was 100% for a wide variety of specimens. This study suggests that such a system will help support pathologists located at distant sites. C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Telemed Directorate, Washington, DC 20307 USA. Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. Heidelberg Army Hosp, Dept Pathol, Heidelberg, Germany. RP Kaplan, KJ (reprint author), Walter Reed Army Med Ctr, Dept Pathol, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 35 TC 53 Z9 53 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD NOV PY 2002 VL 15 IS 11 BP 1197 EP 1204 DI 10.1097/01.MP.0000033928.11585.42 PG 8 WC Pathology SC Pathology GA 619PP UT WOS:000179485400012 PM 12429799 ER PT J AU Fried, M Duffy, PE AF Fried, M Duffy, PE TI Two DBL gamma subtypes are commonly expressed by placental isolates of Plasmodium falciparum (vol 122, pg 201, 2002) SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Correction C1 Seattle Biomed Res Inst, Seattle, WA 98109 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Fried, M (reprint author), Seattle Biomed Res Inst, 4 Nickerson St, Seattle, WA 98109 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD NOV-DEC PY 2002 VL 125 IS 1-2 BP 217 EP 217 AR PII S0166-6851(02)00208-6 DI 10.1016/S0166-6851(02)00208-6 PG 1 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 626FR UT WOS:000179862000023 ER PT J AU Rothwell, SW Wilkins, L Balkaltcheva, I AF Rothwell, SW Wilkins, L Balkaltcheva, I TI Comparison of the structure of lyophilized and air dried blood cells by scanning probe microscopy SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT 42nd Annual Meeting of the American-Society-for-Cell-Biology CY DEC 14-18, 2002 CL SAN FRANCISCO, CALIFORNIA SP Amer Soc Cell Biol C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 2002 VL 13 MA 779 BP 139A EP 139A PG 1 WC Cell Biology SC Cell Biology GA 621BR UT WOS:000179569100778 ER PT J AU Peachman, KK Alving, CR Rao, M Rothwell, SW AF Peachman, KK Alving, CR Rao, M Rothwell, SW TI Intact functional microtubules are required for liposome antigen presentation SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT 42nd Annual Meeting of the American-Society-for-Cell-Biology CY DEC 14-18, 2002 CL SAN FRANCISCO, CALIFORNIA SP Amer Soc Cell Biol C1 Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD USA. Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 2002 VL 13 MA 2670 BP 474A EP 474A PG 1 WC Cell Biology SC Cell Biology GA 621BR UT WOS:000179569102669 ER PT J AU Werrlein, RJ Madren-Whalley, JS AF Werrlein, RJ Madren-Whalley, JS TI Multiphoton microscopy: A window to understanding sulfur-mustard lesions SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT 42nd Annual Meeting of the American-Society-for-Cell-Biology CY DEC 14-18, 2002 CL SAN FRANCISCO, CALIFORNIA SP Amer Soc Cell Biol C1 USA, Med Res Inst Chem Def, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 2002 VL 13 MA 2715 BP 482A EP 482A PG 1 WC Cell Biology SC Cell Biology GA 621BR UT WOS:000179569102714 ER PT J AU Chiang, PK Leach, RA Caridha, D Zhang, P Smith, W AF Chiang, PK Leach, RA Caridha, D Zhang, P Smith, W TI Early gene expressions in cells treated with a sulfur mustard vesicant SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT 42nd Annual Meeting of the American-Society-for-Cell-Biology CY DEC 14-18, 2002 CL SAN FRANCISCO, CALIFORNIA SP Amer Soc Cell Biol C1 Walter Reed Army Inst Res, Silver Spring, MD USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD NOV PY 2002 VL 13 MA 3071 BP 545A EP 545A PG 1 WC Cell Biology SC Cell Biology GA 621BR UT WOS:000179569103070 ER PT J AU Wang, XY Drew, C Lee, SH Senecal, KJ Kumar, J Sarnuelson, LA AF Wang, XY Drew, C Lee, SH Senecal, KJ Kumar, J Sarnuelson, LA TI Electrospun nanofibrous membranes for highly sensitive optical sensors SO NANO LETTERS LA English DT Article ID POLYMER; MORPHOLOGY AB The first use of electrospun nanofibrous membranes as highly responsive fluorescence quenching-based optical sensors for metal ions (Fe3+ and Hg2+) and 2,4-dinitrotoluene (DNT) is reported. A fluorescent polymer, poly(acrylic acid)-poly(pyrene methanol) (PAA-PM), was used as a sensing material. Optical chemical sensors were fabricated by electrospinning PAA-PM and thermally cross-linkable polyurethane latex mixture solutions, These sensors showed high sensitivities due to the high surface area-to-volume ratio of the nanofibrous membrane structures. C1 Univ Massachusetts, Dept Chem & Phys, Ctr Adv Mat, Lowell, MA 01854 USA. USA, Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Dept Chem & Phys, Ctr Adv Mat, Lowell, MA 01854 USA. RI Senecal, Kris/F-3000-2013 NR 14 TC 539 Z9 557 U1 27 U2 191 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD NOV PY 2002 VL 2 IS 11 BP 1273 EP 1275 DI 10.1021/nl020216u PG 3 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 616JZ UT WOS:000179301800019 ER PT J AU Albert, DG AF Albert, DG TI Reduction of blast noise by a snow cover SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID GROUND SURFACES; PROPAGATION; IMPEDANCE AB Experimental measurements were conducted to determine the effect of ground conditions near the source on blast noise levels. The measurements were conducted at two locations, one with temperate soil conditions and one with a seasonal snow cover. Pressure sensors were used to record the waveforms produced by the detonation of 0.57-kg charges of C4 explosive at distances between 10 m and 110 m. The measured blast waveforms were elongated and the peak amplitudes were significantly reduced at all distances when a snow cover was present. These measurements show that the interaction of the blast wave with the ground near the explosion is an important factor in the blast noise levels received at long propagation distances. This finding indicates that modification or control of the ground properties near military artillery training locations is a potential method of mitigating the noise produced by these activities. (C) 2002 Institute of noise Control Engineering. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Albert, DG (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 21 TC 3 Z9 3 U1 0 U2 0 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD NOV-DEC PY 2002 VL 50 IS 6 BP 200 EP 203 DI 10.3397/1.2839691 PG 4 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 681RW UT WOS:000183050000003 ER PT J AU Standley, E Umnova, O Attenborough, K Cummings, A Dutta, P AF Standley, E Umnova, O Attenborough, K Cummings, A Dutta, P TI Shock wave reflection measurements on porous materials SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article AB Shock waves with peak pressures greater than 65 kPa and durations of the order of ms have been generated by membrane rupture inside two air-filled cylindrical tubes of different sizes. The attenuation and the broadening of the pulse measured in both tubes in the absence of absorbing material are found to be consistent with theoretical predictions of non-linear hydrodynamic effects in air. Measurements of shock wave reflection from eight different porous materials have been analyzed. The displacements of the exposed surfaces of three of the materials have been measured in the smaller of the tubes by imbedding rectangular sections of flexible wire in the test samples and subjecting the samples to a strong magnetic field. The voltage fluctuation resulting from dynamic compression of the porous material is proportional to the speed of the surface and, hence, the displacement is obtained by integration of the speed. Results obtained with a sample in which wires are embedded at different chord lengths indicate that the incident shock waves are plane. A 0.3 m long sample of 'soft' partially reticulated polyurethane foam is shown to have the best acoustic performance of the five samples tested and is found also to suffer the greatest surface displacement. However the displacement is found to vary across the tube section. (C) 2002 Institute of Noise Control Engineering. C1 Univ Hull, Dept Engn, Kingston Upon Hull HU6 7RX, N Humberside, England. USACE, CRREL, Hanover, NH 03755 USA. RP Standley, E (reprint author), Univ Hull, Dept Engn, Kingston Upon Hull HU6 7RX, N Humberside, England. NR 4 TC 6 Z9 6 U1 1 U2 4 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD NOV-DEC PY 2002 VL 50 IS 6 BP 224 EP 230 DI 10.3397/1.2839695 PG 7 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 681RW UT WOS:000183050000007 ER PT J AU Thomas, RF Monacci, WT Mair, EA AF Thomas, RF Monacci, WT Mair, EA TI Endoscopic image-guided transethmoid pituitary surgery SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery CY SEP 22-25, 2002 CL SAN DIEGO, CALIFORNIA SP Amer Acad Otolaryngol Head & Neck Surg ID ENDONASAL TRANSSPHENOIDAL SURGERY; TECHNICAL NOTE; HYPOPHYSECTOMY; TRANSNASAL; EXPERIENCE; RESECTION; LESIONS; ADENOMA; SELLAR AB OBJECTIVE: We describe a new endoscopic transethmoid approach for pituitary surgery and to compare it with other surgical techniques. STUDY DESIGN AND SETTING: Eleven patients undergoing pituitary surgery from September 2000 through January 2002 underwent an image-guided endoscopic transethmoid procedure to remove pituitary tumors. Ease of approach, resection, exposure of the surgical field, and operative complications were documented. RESULTS: Endoscopic ethmoidectomy permits enhanced exposure and simplified tumor resection. The use of one nostril to stabilize the endoscope and the other to pass instruments affords a bimanual procedure that avoids the difficulty of small nares and keeping the scope fixed while exchanging instruments. Operative morbidity was low with no significant complications in this pilot study. CONCLUSIONS: This approach opens a generous operative exposure while safely allowing room to endoscopically maneuver and affords direct access should revision surgery be needed. SIGNIFICANCE: This procedure uses a technique familiar to otolaryngologists and may be used for pituitary and other skull base tumors. C1 Walter Reed Army Med Ctr, Otolaryngol Head & Neck Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. RP Mair, EA (reprint author), Wilford Hall USAF Med Ctr, Dept Otolaryngol, 2200 Bergquist Dr,Suite 1, San Antonio, TX 78236 USA. NR 15 TC 23 Z9 27 U1 0 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD NOV PY 2002 VL 127 IS 5 BP 409 EP 416 DI 10.1067/mhn.2002.129821 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 620PT UT WOS:000179542300007 PM 12447234 ER PT J AU Patel, A Jhiang, S Dogra, S Terrell, R Powers, PA Fenton, C Dinauer, CA Tuttle, RM Francis, GL AF Patel, A Jhiang, S Dogra, S Terrell, R Powers, PA Fenton, C Dinauer, CA Tuttle, RM Francis, GL TI Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents SO PEDIATRIC RESEARCH LA English DT Article ID NIS GENE-EXPRESSION; CANCER CELL-LINE; NA+/I SYMPORTER; SODIUM/IODIDE SYMPORTER; RADIOIODIDE UPTAKE; TUMORS; TISSUES; MUTATIONS; DISEASE; THERAPY AB The sodium-iodide symporter (NIS) is expressed by papillary (PTC) and follicular (FTC) thyroid carcinoma, and is essential for iodine uptake. We hypothesized that PTC and FTC with detectable NIS immunostaining would be more amenable to radioactive iodine (I-131) treatment and follow a more benevolent course. To test this, we determined NIS expression by immunohistochemistry in 23 PTC, 9 FTC, and 12 benign thyroid lesions from children and adolescents. NIS expression was determined by two blinded examiners and graded as absent = 0, minimal = 1, moderate = 2, intense = 3, and very intense = 4. NIS was detected in 35% (eight of 23) of PTC, 44% (four of 9) of FTC, 25% (two of eight) of benign tumors, and 100% (four of four) of autoimmune lesions. The intensity of NIS expression was similar in PTC (0.61 +/- 0.24), FTC (0.56 +/- 0.24), and benign tumors (0.50 +/- 0.33) but was more intense in autoimmune lesions (3.0 +/-,0.7, p < 0.005). Distant metastases were found only among PTC with undetectable NIS (two of 15, 13%), and recurrence developed exclusively from PTC and FTC with undetectable NIS (four of 20, 20% versus zero of 12, p = 0.043). The dose of iodine 131 required to achieve remission in the five patients with PTC who had undetectable NIS (213.3 +/- 53 mCi) was greater than that required by patients with similar age and extent of disease for whom NIS expression is unknown (109 +/- 22 mCi, p = 0.06). We conclude that NIS expression is associated with a lower risk of recurrence for PTC and FTC of children and adolescents. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Ohio State Univ, Dept Endocrinol, Columbus, OH 43210 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Dept Endocrinol, New York, NY 10021 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 40 TC 32 Z9 37 U1 0 U2 0 PU INT PEDIATRIC RESEARCH FOUNDATION, INC PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD NOV PY 2002 VL 52 IS 5 BP 737 EP 744 DI 10.1203/01.PDR.0000031920.28469.B8 PG 8 WC Pediatrics SC Pediatrics GA 610TP UT WOS:000178977200020 PM 12409522 ER PT J AU Myers, TM Galbicka, G Sipos, ML Varadi, S Oubre, JL Clark, MG AF Myers, TM Galbicka, G Sipos, ML Varadi, S Oubre, JL Clark, MG TI Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta) SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE biperiden; scopolamine; operant behavior; accuracy; short-term memory; serial probe recognition (SPR); rhesus monkeys; touch screen response ID MEMORY; MONKEYS; SCOPOLAMINE; PERFORMANCE; DIAZEPAM; LISTS; TASK; NEUROPATHOLOGY; BIPERIDEN; ATROPINE AB Potential deleterious behavioral effects of the anticholinergics biperiden and scopolamine were examined via the performance of rhesus monkeys on a serial-probe recognition (SPR) procedure. On each trial, six unique stimuli (list items) were presented sequentially followed by a choice phase, In the choice phase, two stimuli were presented, a standard or 'default' stimulus (a white rectangle) and a 'probe' stimulus that differed with each choice trial. Choosing the probe stimulus was considered correct if the probe matched one of the list items; otherwise, choosing the default stimulus was considered correct. Behavior was examined under a range of doses of biperiden (0.001-1.0 mg/kg) and scopolamine (0.0056-0.03 mg/kg). Scopolamine (0.01-0.03 mg/kg) and biperiden (0.3-1.0 mg/kg) reduced overall accuracy. At the highest dose, scopolamine, but not biperiden. reduced the number of trials completed per session. The results suggest that doses of scopolamine and biperiden necessary to prevent or eliminate organophosphate induced seizures may affect performance adversely. However, because the degree of impairment from biperiden was modest, further examination of this anticonvulsant may be warranted. (C) 2002 Elsevier Science Inc. All rights reserved. C1 Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. Aventis Pharmaceut Inc, US Lab Anim Sci & Welf, Bridgewater, NJ 08807 USA. USA, Med Res Inst Chem Def, Adv Assessment Div, Aberdeen Proving Ground, MD 21010 USA. RP Myers, TM (reprint author), Walter Reed Army Inst Res, Div Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 33 TC 8 Z9 8 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD NOV PY 2002 VL 73 IS 4 BP 829 EP 834 AR PII S0091-3057(02)00909-7 DI 10.1016/S0091-3057(02)00909-7 PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 597CU UT WOS:000178205200012 PM 12213528 ER PT J AU Rohrbaugh, DK Durst, HD Longo, FR Munavalli, S AF Rohrbaugh, DK Durst, HD Longo, FR Munavalli, S TI Trifluoromethylthiolation of 1,3- and 1,4-cyclohexadienes SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE addition and dimerization reactions; cyclohexadienes; trifluoromethylthiyl and chlorine radicals ID ALKENES; 1,3-DIENES; CHLORIDE; PALLADIUM; CATALYSIS; SULFIDES; REAGENTS; EXAMPLE AB Treatment of 1, 3-cyclohexadiene with CF3SCl at -80degrees furnishes 15 compounds. All but the two dimerized adducts arise from the free radical catalyzed addition of CF3S and Cl radicals to carbon-carbon double bonds. One dimerized product arises via dimerization of the substrate itself, while the other results from the cross-coupling of the substrate with the reaction product. The same reaction with 1, 4-cyclohexadiene gives 14 compounds. The mass spectral characterization of various compounds and their probable mechanism of formation are presented in this article. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Aberdeen Proving Ground, MD 21010 USA. RP Munavalli, S (reprint author), Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM sxmunava@SBCCOM.apgea.army.mil NR 64 TC 3 Z9 3 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK,, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD NOV PY 2002 VL 177 IS 11 BP 2639 EP 2650 DI 10.1080/10426500290110865 PG 12 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 620LJ UT WOS:000179534600015 ER PT J AU Das, GP Rao, BK Jena, P Deevi, SC AF Das, GP Rao, BK Jena, P Deevi, SC TI Electronic structure of substoichiometric Fe-Al intermetallics SO PHYSICAL REVIEW B LA English DT Article ID TRANSITION-METAL ALUMINIDES; GROUND-STATE PROPERTIES; CORRELATION-ENERGY; IRON ALUMINIDES; SELF-CONSISTENT; B2 STRUCTURE; MAGNETIC-PROPERTIES; EXCHANGE-ENERGY; NI ALUMINIDES; POINT-DEFECTS AB The formation energy, nature of bonding, electron density of states, and magnetic properties of Fe1-xAlx intermetallics have been calculated in the concentration range 0less than or equal toxless than or equal to0.5 using the tight-binding linearized muffin-tin orbital method and a super unit cell containing 16 atoms. The various concentration ranges are simulated by successively replacing Fe atoms by Al atoms and studying the electronic structure within the density-functional theory and generalized gradient approximation for exchange and correlation. The stability of the Fe1-xAlx alloys increases monotonically with increasing Al concentration, while the magnetic moment variation reveals exactly the opposite behavior. Stoichiometric FeAl is found to exhibit two nearly degenerate magnetic structures: a nonmagnetic state with zero moment on Fe and a ferromagnetic state with a moment of 0.75mu(B) per Fe atom. Fe3Al, on the other hand, is ferromagnetic with a calculated moment of 2.45mu(B) at the Fe-I site and 1.95mu(B) at the Fe-II site. The coupling between Fe and Al atoms is antiferromagnetic, although the moment at the Al site is much smaller (-0.17mu(B)) than that at the Fe sites. The bonding between Fe and Al atoms is primarily due to the hybridization between the 3d electrons of the former and the sp electrons of the latter. The bonding has a strong local character in that the coupling is between the nearest neighbor atoms. This is further verified by a calculation using small clusters as models of the bulk structure. The density of states at the Fermi energy is dominated by contributions from the Fe 3d state although its variation with Al is modulated by subtle interaction with Al 3p electrons. The total densities of states at the Fermi energy of Fe1-xAlx alloys show the same variation as the electrical resistivity, suggesting that the increase and then decrease in resistivity with Al concentration with a peak at 33% Al is purely of electronic origin. C1 Virginia Commonwealth Univ, Dept Phys, Richmond, VA 23284 USA. Philip Morris Inc, Ctr Res Dev & Engn, Richmond, VA 23234 USA. RP Rao, BK (reprint author), Virginia Commonwealth Univ, Dept Phys, Richmond, VA 23284 USA. NR 62 TC 39 Z9 42 U1 1 U2 13 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD NOV 1 PY 2002 VL 66 IS 18 AR 184203 DI 10.1103/PhysRevB.66.184203 PG 13 WC Physics, Condensed Matter SC Physics GA 622EG UT WOS:000179633100025 ER PT J AU Busch, CR Taylor, HA Kanarek, RB Holcomb, PJ AF Busch, CR Taylor, HA Kanarek, RB Holcomb, PJ TI The effects of a confectionery snack on attention in young boys SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE carbohydrate; cognition; attention; children; snacks ID ELDERLY HUMANS; COGNITIVE PERFORMANCE; GLUCOSE ENHANCEMENT; SUGAR INGESTION; BLOOD-GLUCOSE; MEMORY; CHILDREN; BEHAVIOR; ACETYLCHOLINE; HYPOTHESIS AB The relationship between consumption of a confectionery snack after an overnight fast and cognitive function was examined using a variety of cognitive tasks, including spatial memory, verbal memory, attention, visual perception and short-term memory, in a sample of 21 boys, ages 9-12 years. Performance on the vigilance attention task was significantly improved when the participants consumed a confectionery snack compared to consumption of a noncalorie snack. Participants had significantly higher hit rates and significantly lower miss rates after the confectionery snack. In addition, false alarm rates increased as a function of time for the placebo condition and decreased for the confectionery condition. Thus, the confectionery snack enhanced ability to stay on task for an extended period of time, enabling the children to more accurately identify target information, as well as correctly reject nontarget information. Analysis of the types of errors made also revealed that when the children were in the confectionery condition they were less likely to make more glaring errors. No significant differences were found in tests of digit span, verbal memory, spatial memory or visual perception. (C) 2002 Published by Elsevier Science Inc. C1 Tufts Univ, Dept Psychol, Medford, MA 02155 USA. RP Busch, CR (reprint author), USA, Soldier Ctr, Supporting Sci & Technol Directorate, Kansas St, Natick, MA 01760 USA. NR 34 TC 19 Z9 19 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD NOV PY 2002 VL 77 IS 2-3 BP 333 EP 340 AR PII S0031-9384(02)00882-X DI 10.1016/S0031-9384(02)00882-X PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA 614CL UT WOS:000179170700019 PM 12419410 ER PT J AU Lieberman, HR Tharion, WJ Shukitt-Hale, B Speckman, KL Tulley, R AF Lieberman, HR Tharion, WJ Shukitt-Hale, B Speckman, KL Tulley, R TI Effects of caffeine, sleep loss, and stress on cognitive performance and mood during US Navy SEAL training SO PSYCHOPHARMACOLOGY LA English DT Article DE stress; vigilance; mood; alertness; psychotnotor performance; learning; memory; stimulant ID PROLONGED WAKEFULNESS; VISUAL VIGILANCE; WORKING-MEMORY; PSYCHOMOTOR; ALERTNESS; ADENOSINE; HUMANS; EEG; DIAZEPAM; PLASMA AB Rationale: When humans are acutely exposed to multiple stressors, cognitive performance is substantially degraded. Few practical strategies are available to sustain performance under such conditions. Objective: This study examined whether moderate doses of caffeine would reduce adverse effects of sleep deprivation and exposure to severe environmental and operational stress on cognitive performance. Methods: Volunteers were 68 U.S. Navy Sea-Air-Land (SEAL) trainees, randomly assigned to receive either 100, 200, or 300 mg caffeine or placebo in capsule form after 72 h of sleep deprivation and continuous exposure to other stressors. Cognitive tests administered included scanning visual vigilance, four-choice visual reaction time, a matching-to-sample working memory task and a repeated acquisition test of motor learning and memory. Mood state, marksmanship, and saliva caffeine were also assessed. Testing was conducted 1 and 8 h after treatment. Results: Sleep deprivation and environmental stress adversely affected performance and mood. Caffeine, in a dose-dependent manner, mitigated many adverse effects of exposure to multiple stressors. Caffeine (200 and 300 mg) significantly improved visual vigilance, choice reaction time, repeated acquisition, self-reported fatigue and sleepiness with the greatest effects on tests of vigilance, reaction time, and alertness. Marksmanship, a task that requires fine motor coordination and steadiness, was not affected by caffeine. The greatest effects of caffeine were present 1 h post-administration, but significant effects persisted for 8 h. Conclusions: Even in the most adverse circumstances, moderate doses of caffeine can improve cognitive function, including vigilance, learning, memory, and mood state. When cognitive performance is critical and must he maintained during exposure to severe stress. administration of caffeine may provide a significant advantage. A dose of 200 mg appears to be optimal under such conditions. C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. Tufts Univ, Human Nutr Res Ctr Aging, Boston, MA 02111 USA. Pennington Biomed Res Lab, Baton Rouge, LA 70808 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 48 TC 230 Z9 249 U1 9 U2 86 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD NOV PY 2002 VL 164 IS 3 BP 250 EP 261 DI 10.1007/s00213-002-1217-9 PG 12 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 624UD UT WOS:000179779200002 PM 12424548 ER PT J AU Armstrong, SC Cozza, KL AF Armstrong, SC Cozza, KL TI Med-psych drug-drug interactions update - Triptans SO PSYCHOSOMATICS LA English DT Article ID PHARMACOKINETIC INTERACTION; HEALTHY-VOLUNTEERS; ALMOTRIPTAN AB Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT1B/1D receptors, they differ pharmacokinetically. This coulmn reviews how the triptans are metabolized. Generally the triptans are metabolized by phase 1 monoamine oxidases (MAOs) and by various cytochrome P450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan's potential for drug-drug interactions. These differences are detailed in this review. C1 Tual Forest Grove Hosp, Ctr Geriatr Psychiat, Forest Grove, OR 97116 USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Armstrong, SC (reprint author), Tual Forest Grove Hosp, Ctr Geriatr Psychiat, 1809 Maple St, Forest Grove, OR 97116 USA. NR 9 TC 10 Z9 10 U1 0 U2 0 PU AMER PSYCHIATRIC PRESS, INC PI WASHINGTON PA 1400 K ST, N W, STE 1101, WASHINGTON, DC 20005 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD NOV-DEC PY 2002 VL 43 IS 6 BP 502 EP 504 DI 10.1176/appi.psy.43.6.502 PG 3 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 614DW UT WOS:000179173900012 PM 12444236 ER PT J AU Johnstone, PAS Kane, CJ Sun, L Wu, HY Moul, JW McLeod, DG Martin, DD Kusuda, L Lance, R Douglas, R Donahue, T Beat, MG Foley, J Baldwin, D Soderdahl, D Do, J Amling, CL AF Johnstone, PAS Kane, CJ Sun, L Wu, HY Moul, JW McLeod, DG Martin, DD Kusuda, L Lance, R Douglas, R Donahue, T Beat, MG Foley, J Baldwin, D Soderdahl, D Do, J Amling, CL TI Effect of race on biochemical disease-free outcome in patients with prostate cancer treated with definitive radiation therapy in an equal-access health care system: Radiation oncology report of the department of defense center for prostate disease research SO RADIOLOGY LA English DT Article DE data analysis; prostate neoplasms; prostate neoplasms, therapeutic radiology ID EXTERNAL-BEAM RADIATION; AFRICAN-AMERICAN MEN; DATA-BASE REPORT; RADICAL PROSTATECTOMY; PROGNOSTIC FACTOR; ANTIGEN VALUES; UNITED-STATES; 1989 PATTERNS; CARCINOMA; SURVIVAL AB PURPOSE: To report on the first collaboration of the Department of Defense Center for Prostate Disease Research concerned with the relationship between African American race and biochemical disease-free outcomes after definitive radiation therapy. MATERIALS AND METHODS: Information from the medical records of 1,806 patients (1,349 white, 343 African American, 42 of "other" races, and 72 of "unknown" races) treated with definitive radiation therapy between 1973 and 2000 was reviewed. Patients receiving adjuvant hormonal therapy or postoperative adjuvant or salvage radiation therapy were excluded. Biochemical failure was calculated in over 96% of cases by using ASTRO criteria; patients with fewer than three follow-up visits were considered to have biochemical failure with a prostate-specific antigen (PSA) value more than 10-fold the previous value or with any value greater than 50.0 ng/mL. Median radiation therapy doses were similar. The median follow-up was 58.4 months. Kaplan-Meier tests, Cox proportional hazards regression analysis, and log-rank tests were used for data analysis. RESULTS: There was no statistically significant difference in biochemical disease-free survival according to race when patients were stratified according to T stage. African American race conferred a negative prognosis for patients with lesions of Gleason biopsy score 7 (P = .004) but not for patients with lesions of Gleason score 2-4 (P = .14), 5-6 (P = .79), or 8-10 (P = .86). Similarly, African American race conferred a negative prognosis in patients with PSA values of 20.1-50.0 ng/mL (P = .01) at presentation but not in patients with PSA values less than or equal to 4.0 ng/mL (P = .84), 4.1-10.0 ng/mL (P = .71),10.1-20.0 ng/mL (P = .75), or above 50.0 ng/mL (P = .15) at presentation. At multivariate analysis, race was not a statistically significant predictor of outcome. CONCLUSION: In the equal-access health care system of the Department of Defense, African American race is not associated with a consistently negative prognosis in patients treated with definitive radiation therapy for prostate cancer. Race appears to confer a negative prognosis only in patients with advanced disease at presentation. C1 USN, Med Ctr, San Diego, CA 92134 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, Med Ctr, Portsmouth, VA USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. USN, Natl Med Ctr, Bethesda, MD 20084 USA. Brooke Army Med Ctr, San Antonio, TX USA. Malcolm Grow Air Force Med Ctr, Andrews AFB, MD USA. Eisenhower Army Med Ctr, Augusta, GA USA. Univ Calif San Diego, San Diego, CA USA. RP Johnstone, PAS (reprint author), USN, Med Ctr, San Diego, CA 92134 USA. NR 37 TC 23 Z9 23 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD NOV PY 2002 VL 225 IS 2 BP 420 EP 426 DI 10.1148/radiol.2252011491 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 608AG UT WOS:000178822500017 PM 12409575 ER PT J AU Dinauer, P Bojescul, JA Kaplan, KJ Litts, C AF Dinauer, P Bojescul, JA Kaplan, KJ Litts, C TI Bilateral lipoma arborescens of the bicipitoradial bursa SO SKELETAL RADIOLOGY LA English DT Article DE lipoma arborescens; elbow; bicipitoradial bursa; magnetic resonance imaging ID IMAGING FINDINGS; KNEE AB A 37-year-old military mechanic presented to our institution with a chronic history of a slowly enlarging left elbow antecubital fossa mass. There was no history of other chronic illness or trauma. Magnetic resonance imaging (MRI) and excisional biopsy revealed fatty villi and synovial inflammation within the left bicipitoradial bursa, consistent with lipoma arborescens. Four years later the patient presented with a 6-month history of swelling at the antecubital fossa of the opposite elbow. Diagnostic computed tomography and MRI examinations were performed. The surgical and pathologic findings confirmed the imaging diagnosis of lipoma arborescens at the right bicipitoradial bursa. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil Serv, Orthopaed Surg Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Bojescul, JA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil Serv, Orthopaed Surg Serv, Washington, DC 20307 USA. NR 19 TC 22 Z9 23 U1 0 U2 0 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD NOV PY 2002 VL 31 IS 11 BP 661 EP 665 DI 10.1007/s00256-002-0569-x PG 5 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA 614VD UT WOS:000179211400008 PM 12395279 ER PT J AU Bauer, AJ Terrell, R Doniparthi, NK Patel, A Tuttle, RM Saji, M Ringel, MD Francis, GL AF Bauer, AJ Terrell, R Doniparthi, NK Patel, A Tuttle, RM Saji, M Ringel, MD Francis, GL TI Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice SO THYROID LA English DT Article ID TUMOR ANGIOGENESIS; FACTOR EXPRESSION; LIVER METASTASIS; P53; CARCINOMA; THALIDOMIDE; MODEL; GENE AB Background: Anaplastic thyroid cancer (ATC) does not respond well to any treatment and is one of the most aggressive of all human cancers. Based on the importance of angiogenesis in solid tumor growth, we hypothesized that angiogenic blockade might reduce the growth of ATC. Methods: We tested the in vivo effect of vascular endothelial growth factor monoclonal antibody (VEGF-mAb) and thalidomide against ATC (ARO-81) xenografts in nude mice. Mice were injected subcutaneously with I X 101 ARO-81 cells, allowed to implant (I week), and then given daily intraperitoneal injections of vehicle (control; n = 9), VEGF-mAb (200 mug/d; n = 9), or thalidomide (200 mg/kg per day; n = 9). Tumors were removed, sectioned, and stained for routine histology and immunohistochemistry. Results: At 6 weeks, VEGF-mAb-treated tumors were smaller (1603 +/- 296 mm(3)) than either the thalidomide-treated (6007 +/- 1498 mm(3); p = 0.008) or the control groups (4040 +/- 831 mm(3); p = 0.014) and the VEGF-mAb-treated animals maintained greater weight (30.4 +/- 0.84 g at week 6 versus thalidomide-treated, 26.0 +/- 0.94 g, p = 0.003; and control, 25.8 +/- 0.78 g, p = 0.001 animals). Central necrosis was observed in 3 of 9 VEGF-mAb-treated confidence interval (33%; 95% [CI] = 0.12-0.65) but in none of the control or thalidomide-treated tumors (0/18 total; 95% Cl 0.0-0.30; p = 0.029). VEGF staining intensity for VEGF-mAb- (2.0 +/- 0.24; p = 0.012) and thalidomide- (2.1 +/- 0.05; p = 0.052) treated tumors was greater than control (0.89 +/- 0.31) as was p53 staining grade (VEGF-mAb [1.3 +/- 0.37; p = 0.012]; thalidomide [1.0 +/- 0.41; p = 0.05]; and controls [0.11 +/- 0.11]). Conclusion: We conclude that systemic VEGF-mAb significantly reduces growth of ATC xenografts and is associated with increased VEGF and p53 expression. Thalidomide has no effect on tumor growth, but is also associated with increased VEGF and p53 expression. These observations provide the first evidence that VEGF-mAb-induced angiogenesis blockade may be of use for the treatment of ATC. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Endocrinol Sect, New York, NY 10021 USA. MedStar Res Inst, Washington, DC USA. Washington Hosp Ctr, Dept Endocrinol, Washington, DC 20010 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RI Saji, Motoyasu/E-4007-2011 NR 34 TC 40 Z9 42 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 1050-7256 J9 THYROID JI Thyroid PD NOV PY 2002 VL 12 IS 11 BP 953 EP 961 DI 10.1089/105072502320908286 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 620MZ UT WOS:000179538300004 PM 12490072 ER PT J AU Paquette, EL Sun, L Paquette, LR Connelly, R McLeod, DG Moul, JW AF Paquette, EL Sun, L Paquette, LR Connelly, R McLeod, DG Moul, JW TI Improved prostate cancer-specific survival and other disease parameters: Impact of prostate-specific antigen testing SO UROLOGY LA English DT Article ID MORTALITY; TRENDS; SERUM AB Objectives. To determine how the implementation of prostate-specific antigen (PSA) testing has affected disease-specific survival and other characteristics of prostate cancer. Methods. Data were collected on all patients with prostate cancer diagnosed between 1988 and 1998 and registered in the Center for Prostate Disease Research Database at Walter Reed Army Medical Center. Statistical analyses were used to summarize trends over time in survival, mortality, and clinical stage. Results. Between 1988 and 1998, a total of 2042 patients with prostate cancer were registered at Walter Reed Army Medical Center. The 5-year disease-specific survival rate was 86.9% and 93.7% for patients diagnosed in the respective year groups of 1988 to 1991 and 1992 to 1994, with follow-up through December 1, 2000 (P < 0.001). Prostate cancer was the cause of death for 37.5% of the patients in 1988 to 1989 versus 15.4% in 1999 to 2000. Marked stage migration has occurred; from 1988 to 1998, the percentage of patients presenting with metastatic disease decreased from 14.1% to 3.3% (P < 0.001). Conclusions. A statistically significant improved 5-year disease-specific survival and a decreased chance of dying from prostate cancer has occurred after the widespread implementation of PSA. We suspect that PSA testing has resulted in fewer patients presenting with metastatic disease and more patients presenting with localized disease amenable to curative treatment. This portends well for the use of PSA screening to improve outcomes for prostate cancer. However, randomized trials are needed to confirm the improvements in survival and mortality. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20892 USA. Ctr Prostate Dis Res, Rockville, MD USA. Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. RP Moul, JW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Bethesda, MD 20892 USA. NR 14 TC 59 Z9 62 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 2002 VL 60 IS 5 BP 756 EP 759 AR PII S0090-4295(02)01960-X DI 10.1016/S0090-4295(02)01960-X PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 614KU UT WOS:000179188700005 PM 12429290 ER PT J AU Taylor, JA Gancarczyk, KJ Fant, GV McLeod, DG AF Taylor, JA Gancarczyk, KJ Fant, GV McLeod, DG TI Increasing the number of core samples taken at prostate needle biopsy enhances the detection of clinically significant prostate cancer SO UROLOGY LA English DT Article AB Objectives. The number of cores obtained during transrectal ultrasound-guided prostate biopsy to detect cancer has increased from the previous standard of 6. Increasing the number of biopsy cores taken results in a higher prostate cancer detection rate. Because criteria for defining the clinical significance of localized prostate cancer has been proposed, the question may be asked whether the increased number of tumors found is clinically significant. Methods. The Urology Service's surgical log database revealed 369 patients who underwent radical prostatectomy as primary therapy between January 1997 and March 2001. Only men who had had more than six core biopsies that included the standard sextant and lateral horns of the peripheral zone biopsies were considered. The hospital's clinical information system was then used to extract all additional data for age, clinical stage, pretreatment prostate-specific antigen level, and transrectal ultrasound-guided biopsy and subsequent whole mount pathology results, including pathologic stage, number of tumors, largest single and aggregate tumor volumes, highest tumor Gleason score, and tumor locations. A total of 127 men comprised our final group. Results. Subgrouping based on the location of positive biopsy results yielded 40 (31.5%) in the standard sextant biopsy only, 31 (24.4%) in the lateral horns of the peripheral zone only, and 56 (44.1%) of 127 tumors in both zones. The Gleason score was similar throughout. The margin-positive rate was 12.5% for the sextant-only positive biopsies, 12.9% for the lateral horn-only positive biopsies, and 42.9% for the both positive biopsies. The insignificant tumor rate for the group as a whole was 5.5% (7 of 127). The insignificant tumor rate for the lateral horn-only positive biopsies was 3.2% (1 of 31). Conclusions. The addition of laterally directed biopsies increases the rate of prostate cancer detection, and the vast majority of these tumors are clinically significant. Published by Elsevier Science Inc. C1 Walter Reed Army Med Ctr, Div Urol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest Biometr, Washington, DC 20307 USA. RP Taylor, JA (reprint author), Walter Reed Army Med Ctr, Div Urol, 4F,6900 Georgia Ave, Washington, DC 20307 USA. NR 12 TC 34 Z9 35 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 2002 VL 60 IS 5 BP 841 EP 845 AR PII S0090-4295(02)01878-2 DI 10.1016/S0090-4295(02)01878-2 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 614KU UT WOS:000179188700027 PM 12429312 ER PT J AU Vladimiroff, T Rice, BM AF Vladimiroff, T Rice, BM TI Reinvestigation of the gas-phase structure of RDX using density functional theory predictions of electron-scattering intensities SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID AB-INITIO; CONFORMATIONS; ENERGIES AB Density functional calculations at the B3LYP/6-31G* level are used to generate electron-diffraction intensity curves for six conformers of hexahydro-1,3,5-trinitro-s-triazine (RDX). These are compared with an experimental curve (Shishkov, 1. F.; Vilkov, L. V.; Lolonits, M.; Rozsondai, B. Struct. Chem. 1991, 2, 57) for which a structural model of gas-phase RDX was proposed. The calculations were done to investigate possible causes of the discrepancies between the theoretical structures and the molecular model proposed by Shishkov et al. The results show that alternative structures to that proposed from experiment can reproduce the measured intensities. Also, barriers to interconversion between the conformers were calculated to investigate the possibility of rapid interconversion at the temperature of the experiment (433 K). Barriers range from 1.5 to 5 kcal/mol, suggesting that measurements of RDX in the gas phase might reflect a dynamically averaged structure that represents contributions from the individual conformers. C1 USA, Res Lab, AMSRL, WM,BD, Aberdeen Proving Ground, MD 21005 USA. USA, TACOM, ARDEC, Energet & Combat Support Armanents Ctr, Picatinny Arsenal, NJ 07806 USA. RP Rice, BM (reprint author), USA, Res Lab, AMSRL, WM,BD, Aberdeen Proving Ground, MD 21005 USA. NR 22 TC 41 Z9 41 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD OCT 31 PY 2002 VL 106 IS 43 BP 10437 EP 10443 DI 10.1021/jp021450b PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 608XW UT WOS:000178873900043 ER PT J AU Grujicic, M Cao, G Gersten, B AF Grujicic, M Cao, G Gersten, B TI Optimization of the chemical vapor deposition process for carbon nanotubes fabrication SO APPLIED SURFACE SCIENCE LA English DT Article DE carbon nanotubes; chemical vapor deposition; genetic algorithm ID MATHEMATICAL-MODEL; SCALE ANALYSIS; DIAMOND; GROWTH; CVD; REACTOR; ARRAYS AB A coupled boundary-layer laminar-flow hydrodynamic, heat-transfer, gas-phase chemistry and surface chemistry model is developed to analyze, at the reactor length-scale, chemical vapor deposition (CVD) of carbon nanotubes from a gas mixture consisting of methane (carbon precursor) and hydrogen (carrier gas) in the presence of cobalt catalytic particles in a cylindrical reactor. The model allows determination of the gas-phase fields for temperature, velocity, and species concentration as well as the surface species coverages, the carbon nanotubes growth rate and the deposition rate of amorphous carbon. Experimentally determined carbon deposition rates and carbon nanotubes growth rates at different processing conditions are used to validate the model. The model is also coupled with the Genetic Algorithm to determine the process parameters (the gas temperature and velocity at the reactor inlet, the reactor-wall temperature, the pressure, and the mole fraction of methane in the gas mixture) which maximize the carbon nanourbes yield while minimizing the amount of deposited amorphous carbon. (C) 2002 Elsevier Science B.V All rights reserved. C1 Clemson Univ, Dept Engn Mech, Program Mat Sci & Engn, Clemson, SC 29634 USA. USA, Res Lab, WMRD, AMSRL,WM,MD, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Engn Mech, Program Mat Sci & Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Cao, guoxin/A-9790-2012 OI Cao, guoxin/0000-0002-6598-2899 NR 35 TC 33 Z9 35 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD OCT 30 PY 2002 VL 199 IS 1-4 BP 90 EP 106 AR PII S0169-4332(02)00892-9 DI 10.1016/S0169-4332(02)00892-9 PG 17 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA 609HC UT WOS:000178896700011 ER PT J AU Xia, XH Hu, ZB Gao, J Qin, DJ Durst, HDD Yin, R AF Xia, XH Hu, ZB Gao, J Qin, DJ Durst, HDD Yin, R TI Light scattering study of the self-association behavior of long chain branched poly(2-ethyloxazoline) in solvents SO LANGMUIR LA English DT Article ID STARBURST DENDRIMERS; DENDRITIC MACROMOLECULES; PAMAM DENDRIMERS; POLYMERS; POLYMERIZATION; COPOLYMERS; TOPOLOGY; SHAPE; SIZE AB Self-association behavior and conformation variation of long chain branched (LCB) poly(2-ethyloxazoline) (PEOx) with a CH3-(CH2)(17) (C-18) modified surface are investigated using light scattering techniques in various solvents. It is found that this LCB-PEOx self-associates in less polar solvents to furs) metastable nanoaggregates instead of undergoing precipitation. The critical aggregation concentration (cac) of this LCB polymer was obtained from the sharp increase of both hydrodynamic radius (R-h) and scattering light intensity measured in dynamic light scattering. The cac strongly depends on solvent polarity, decreasing as the solvent becomes more hydrophobic. As the polarity of the solvent increases, C-18 chains move from the outside surface to the interior. Inward movement of C18 chains can cause coupled LCB-polymer chains to move with them, resulting in shrinkage of the particle size. The self-association process in the LCB-PEOx involves intrachain (C-18 chains) collapse and interchain association. By a combination of dynamic and static light scattering, the average density of individual LCB-PEOx molecules in ethanol was estimated below the cac. The hydrodynamic radius of the LCB-PEOx in ethanol was found to shrink upon increasing temperature, indicating that the solvent becomes poorer. During the heating process, self-association did not occur. C1 Univ N Texas, Dept Chem & Phys, Denton, TX 76203 USA. USA, SBCCOM, Aberdeen Proving Ground, MD 21005 USA. USA, Res Lab, AMSRL WM, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Yin, R (reprint author), Univ N Texas, Dept Chem & Phys, POB 311427, Denton, TX 76203 USA. NR 34 TC 6 Z9 6 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD OCT 29 PY 2002 VL 18 IS 22 BP 8302 EP 8308 DI 10.1021/la020304u PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 608HC UT WOS:000178839300008 ER PT J AU Schoepp, RJ Smith, JF Parker, MD AF Schoepp, RJ Smith, JF Parker, MD TI Recombinant chimeric western and eastern equine encephalitis viruses as potential vaccine candidates SO VIROLOGY LA English DT Article DE western equine encephalitis; eastern equine encephalitis; alphavirus; chimera; cDNA infectious clone; vaccine ID ROSS RIVER VIRUS; INFECTIOUS RNA TRANSCRIPTS; SEMLIKI-FOREST-VIRUS; SINDBIS VIRUS; INVITRO MUTAGENESIS; LETHAL MUTATIONS; CDNA CLONES; GENOMIC RNA; ALPHAVIRUSES; ENCEPHALOMYELITIS AB Chimeric cDNA clones, pMWE1000 and pMWE2000, differing by five nucleotides at their 5' termini, were constructed of the 5' two-thirds of the western equine encephalitis (WEE) virus genome (encoding nonstructural proteins) and the 3' one-third of the eastern equine encephalitis (EEE) virus genome (encoding structural proteins). The WEE virus sequences were derived from full-length cDNA clones, pWE1000 and pWE2000, which were isogenic except for five nucleotide differences at their 5' termini and were responsible for significant differences in mouse virulence. Each cDNA clone was placed downstream from a T7 promoter to allow in vitro transcription of full-length RNA. Transfection of BHK-21 cells with the chimeric RNA by electroporation gave rise to high-titer infectious virus. The in vitro characteristics of each chimera virus were determined by electrophoretic analysis of its structural proteins, plaque morphology, neutralization characteristics, replication kinetics, and rate of viral RNA synthesis. With the exception of plaque morphology, the in vitro characteristics of MWE1000 and MWE2000 were indistinguishable from the parental EEE virus. Subcutaneous inoculation of 5-week-old C57BL/6 mice with varying doses of MWE1000 or MWE2000 virus demonstrated that both chimeric viruses were significantly attenuated compared to the parental WEE virus (Cba 87) and EEE virus (PE-6). Animals infected with 10(5) PFU or more of either MWE1000 or MWE2000 were completely protected from lethal challenge with the virulent EEE virus, FL91-4679, but were not protected from virulent WEE virus Cba 87 challenge. Construction of viable virus chimeras often results in attenuated viruses that may hold promise as genetically engineered alphavirus vaccine candidates. C1 USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Schoepp, RJ (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 33 TC 39 Z9 41 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD OCT 25 PY 2002 VL 302 IS 2 BP 299 EP 309 DI 10.1006/viro.2002.1677 PG 11 WC Virology SC Virology GA 613PJ UT WOS:000179140400010 PM 12441074 ER PT J AU Yushin, GN Wolter, SD Kvit, AV Collazo, R Stoner, BR Prater, JT Sitar, Z AF Yushin, GN Wolter, SD Kvit, AV Collazo, R Stoner, BR Prater, JT Sitar, Z TI Study of fusion bonding of diamond to silicon for silicon-on-diamond technology SO APPLIED PHYSICS LETTERS LA English DT Article AB Diamond films grown on silicon were polished to a root-mean-square roughness of 15 nm and bonded to (100) silicon in a dedicated ultrahigh vacuum bonding chamber. Successful bonding was observed at temperatures as low as 950 degreesC under a uniaxial mechanical stress of 32 MPa. Scanning acoustic microscopy indicated complete bonding at fusion temperatures above 1150 degreesC, and some cracking of the diamond film. Cross section transmission electron microscopy of the same specimens revealed an intermediate layer consisting of silicon, carbon, and oxygen. This layer was approximately 30 nm thick and had an amorphous structure. (C) 2002 American Institute of Physics. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. MCNC, Mat & Elect Technol Div, Res Triangle Pk, NC 27709 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Yushin, GN (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. RI Stoner, Brian/D-9747-2011; Yushin, Gleb/B-4529-2013 OI Yushin, Gleb/0000-0002-3274-9265 NR 8 TC 19 Z9 19 U1 1 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 21 PY 2002 VL 81 IS 17 BP 3275 EP 3277 DI 10.1063/1.1516636 PG 3 WC Physics, Applied SC Physics GA 604MH UT WOS:000178624900053 ER PT J AU Stiegler, G Armbruster, C Vcelar, B Stoiber, H Kunert, R Michael, NL Jagodzinski, LL Ammann, C Jager, W Jacobson, J Vetter, N Katinger, H AF Stiegler, G Armbruster, C Vcelar, B Stoiber, H Kunert, R Michael, NL Jagodzinski, LL Ammann, C Jager, W Jacobson, J Vetter, N Katinger, H TI Antiviral activity of the neutralizing antibodies 2F5 and 2612 in asymptomatic HIV-1-infected humans: a phase I evaluation SO AIDS LA English DT Article DE HIV-1; human monoclonal antibodies; antiviral effects; HIV therapy ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; CLINICAL-TRIALS GROUP; PASSIVE IMMUNOTHERAPY; HIV-INFECTION; GLYCOPROTEIN; PROTECTION; MACAQUES; EPITOPE; PLASMA AB Background: The human monoclonal antibodies (MAbs) 2F5 and 2612 were identified to be two of the most potent neutralizing antibodies against HIV-1. In a first human study they have been shown to be safe after repeated intravenous infusions to 'symptomatic HIV-1-infected individuals. However, the antiviral effects of antibody treatment have not been fully analyzed in this first clinical trial. Methods: The aim of the present study was to gain a preliminary insight into the antiviral effects of 2F5 and 2612 in humans. For this purpose, plasma samples obtained from the previous phase I study were studied for RNA copy numbers by reverse transcriptase-polymerase chain reaction. As a measure for activation of complement levels of the major complement factor C3 were measured by enzyme-linked immunosorbent assay. Flow cytometry was used to study T-lymphocyte counts and the amount of infected peripheral blood mononuclear cells (PBMC) was determined by co-culture with uninfected donor PBMC. Virus escape from antibody neutralization was determined in vitro in a PBMC neutralization assay. Results: Transient reduction in viral loads was observed in five of seven patients. Vigorous complement activation was observed directly after HIV-specific antibody infusions. The number of infective peripheral blood mononuclear cells was reduced in some patients whereas CD4+ T-lymphocyte counts and CD4+/CD8+ ratios were transiently increased in all patients. Virus escape occurred only against 2G12. Conclusions: Analysis of disease progression markers indicate that antibody therapy may have antiviral effects. These findings suggest that neutralizing antibodies should be further evaluated as an alternative therapeutic approach in HIV-1 disease. (C) 2002 Lippincott Williams Wilkins. C1 Univ Agr Sci, Inst Appl Microbiol, A-1190 Vienna, Austria. SMZ Baumgartner Hohe, Dept Med 2, Vienna, Austria. Univ Innsbruck, Inst Hyg, Innsbruck, Austria. Walter Reed Army Inst Res, Rockville, MD USA. Henry M Jackson Fdn, Rockville, MD USA. Univ Vienna, Inst Pharmaceut Chem, A-1090 Vienna, Austria. Mt Sinai Med Ctr, New York, NY 10029 USA. RP Stiegler, G (reprint author), Univ Agr Sci, Inst Appl Microbiol, Muthgasse 18B, A-1190 Vienna, Austria. EM G.Stiegler@iam.boku.ac.at RI Jager, Walter/I-6242-2013 OI Jager, Walter/0000-0002-4970-8179 NR 22 TC 71 Z9 72 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD OCT 18 PY 2002 VL 16 IS 15 BP 2019 EP 2025 DI 10.1097/00002030-200210180-00006 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 612FR UT WOS:000179064300006 PM 12370500 ER PT J AU Hoelscher, M Dowling, WE Sanders-Buell, E Carr, JK Harris, ME Thomschke, A Robb, ML Birx, DL McCutchan, FE AF Hoelscher, M Dowling, WE Sanders-Buell, E Carr, JK Harris, ME Thomschke, A Robb, ML Birx, DL McCutchan, FE TI Detection of HIV-1 subtypes, recombinants, and dual infections in east Africa by a multi-region hybridization assay SO AIDS LA English DT Article DE HIV-subtypes; MHA; genotyping; recombination; dual infection; Africa ID HETERODUPLEX MOBILITY ASSAY; POLYMERASE-CHAIN-REACTION; VACCINE EVALUATION SITES; AMPLIFICATION ASSAY; TYPE-1; SEQUENCE; STRAINS; SAMPLES AB Objective: To enable more rapid and efficient genotyping of HIV-1 in East Africa, where subtypes A, C, and D and their recombinants are co-circulating. Design: Full-genome sequencing of HIV-1 provides complete discrimination of subtypes and recombinant forms but is costly and low-throughput compared to other genotyping approaches. Here we describe the development and evaluation of a Multi-region Hybridization Assay (MHA) for the efficient determination of HIV-1 subtypes A, C, D, recombinants, and dual infections. Methods: Five genome regions containing clustered mutations distinguishing subtypes A, C, and D were identified and used to design subtype-specific probes. DNA from primary peripheral blood mononuclear cells was used as template for real-time PCR using the fluorescent, subtype-specific probes. Results: A panel of 45 clinical samples from Uganda, Kenya, and Tanzania, previously characterized by full-genome sequencing and including 26 pure subtypes and 19 recombinant strains, was evaluated by MHA. The MHA provided 90% sensitivity and 98% specificity for the three subtypes, efficiently discriminated subtypes from recombinant forms, and detected several dual infections. Conclusions: Accurate and efficient genotyping of HIV-1 strains in vaccine trial populations in East Africa, ascertainment of dual infections, and elucidation of the genesis of recombinant forms in individuals can be facilitated by the application of MHA. (C) 2002 Lippincott Williams Wilkins. C1 Univ Munich, Dept Trop Med & Infect Dis, D-80802 Munich, Germany. Walter Reed Army Inst Res, Washington, DC USA. Henry M Jackson Fdn, Rockville, MD USA. RP Hoelscher, M (reprint author), Univ Munich, Dept Trop Med & Infect Dis, Leopoldstr 5, D-80802 Munich, Germany. RI Hoelscher, Michael/D-3436-2012 NR 22 TC 87 Z9 87 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD OCT 18 PY 2002 VL 16 IS 15 BP 2055 EP 2064 DI 10.1097/00002030-200210180-00011 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 612FR UT WOS:000179064300011 PM 12370505 ER PT J AU McCutchan, FE Carr, JK Murphy, D Piyasirisilp, S Gao, F Hahn, B Yu, XF Beyrer, C Birx, DL AF McCutchan, FE Carr, JK Murphy, D Piyasirisilp, S Gao, F Hahn, B Yu, XF Beyrer, C Birx, DL TI Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in china SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID INJECTING DRUG-USERS; FORMER SOVIET-UNION; SUBTYPE-A; GENETIC DIVERSITY; SOUTHERN CHINA; INTERSUBTYPE RECOMBINANTS; 2 SUBTYPES; SPREAD; GENOME; IDENTIFICATION AB Two different BC recombinant HIV-1 strains have arisen and begun to circulate among intravenous drug users in China. The recombinants are mostly subtype C with a few small subtype B segments. Additional full-genome sequences of the two recombinants, termed CRF07_BC and CRF08_BC, are now available for analysis. Four CRF07_BC strains, including c54, 97CN001, 98CN009, and a new strain CNGL-179, described here, and four CRF08_BC strains, including 97CNGX-6, 97CNGX-7, 97CNGX-9, and 98CN006, were compared for their recombination breakpoints by bootscanning and software for fine mapping of recombinants. The four CRF07_BC strains shared an identical recombination structure and the four CRF08 BC strains shared an identical, but different, recombination structure. The two CRFs share five precise subtype B/C boundaries, although although other segments differ between them, suggesting that they shared a common ancestor, itself a BC recombinant that separately "back-crossed" onto different subtype C strains. Both CRFs are broadly distributed from north to south in western China and have maintained low interpatient diversity. C1 Henry M Jackson Fdn, Rockville, MD 20850 USA. Chiang Mai Univ, Chiang Mai 50200, Thailand. Duke Univ, Chapel Hill, NC 27708 USA. Univ Alabama, Birmingham, AL 35294 USA. Johns Hopkins Univ, Baltimore, MD 21205 USA. Walter Reed Army Inst Res, Rockville, MD 20850 USA. RP McCutchan, FE (reprint author), Henry M Jackson Fdn, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. NR 29 TC 25 Z9 28 U1 1 U2 3 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 15 PY 2002 VL 18 IS 15 BP 1135 EP 1140 DI 10.1089/088922202320567879 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 601JM UT WOS:000178442700005 ER PT J AU Hierholzer, M Graham, RR El Khidir, I Tasker, S Darwish, M Chapman, GD Fagbami, AH Soliman, A Birx, DL McCutchan, F Carr, JK AF Hierholzer, M Graham, RR El Khidir, I Tasker, S Darwish, M Chapman, GD Fagbami, AH Soliman, A Birx, DL McCutchan, F Carr, JK TI HIV type 1 strains from East and West Africa are intermixed in Sudan SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION AB The genetic subtypes of HIV-1 in the Sudan epidemic have not been characterized. Here we report the partial sequencing and analysis of 30 strains collected from HIV-1-positive patients and blood donors in Khartoum in 1998 and 1999. From analysis of partial pol and env sequences, it was determined that 50% were subtype D and 30% were subtype C. Of interest, some subtype D clustered with those from East Africa whereas others joined subtype D from West Africa. Subtype A, subtype B, and three unique recombinants were also found, some partially unclassifiable. One unclassified strain matched another reported previously from the Democratic Republic of Congo. Sudan borders nine other African countries, and has suffered more than 20 years of civil strife with large population displacements. The intermixing of HIV-1 subtypes previously separated in Africa may be occurring there, with the potential to generate novel new strains by recombination. C1 Henry M Jackson Fdn, Rockville, MD 20850 USA. USN, Virol Res Program, Med Res Unit 3, Cairo, Egypt. Minist Hlth Sudan, Khartoum, Sudan. USN, Med Res Ctr, Silver Spring, MD 20850 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP Carr, JK (reprint author), Henry M Jackson Fdn, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. RI Saad, Magdi/H-5561-2013 OI Saad, Magdi/0000-0003-2111-8115 NR 9 TC 20 Z9 21 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 15 PY 2002 VL 18 IS 15 BP 1163 EP 1166 DI 10.1089/088922202320567923 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 601JM UT WOS:000178442700010 PM 12402957 ER PT J AU Taylor, AJ Kent, SM Flaherty, PJ Coyle, LC Markwood, TT Vernalis, MN AF Taylor, AJ Kent, SM Flaherty, PJ Coyle, LC Markwood, TT Vernalis, MN TI ARBITER: Arterial biology for the investigation of the treatment effects of reducing cholesterol - A randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness SO CIRCULATION LA English DT Article DE atherosclerosis; lipids; risk factors; hydroxymethylglutaryl coenzyme A reductase inhibitors ID C-REACTIVE PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY HEART-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS RISK; SERUM-CHOLESTEROL; WALL THICKNESS; PROGRESSION AB Background-Whether marked LDL reduction to levels well below 100 mg/dL would further reduce the burden of cardiovascular disease is controversial. We compared the effects of 2 statins with widely differing potencies for LDL reduction (pravastatin 40 mg/d and atorvastatin 80 mg/d) on carotid intima-media thickness (CIMT). Methods and Results-This was a single-center, randomized, clinical trial of 161 patients (mean age, 60 years; 71.4% male; 46% with known cardiovascular disease) that met National Cholesterol Education Program (NCEP) II criteria for lipid-lowering therapy. The effects of atorvastatin (80 mg/d; n=79) and pravastatin (40 mg/d; n=82) on CIMT were compared using blinded, serial assessments of the far wall of the distal common carotid artery. Baseline CIMT and other characteristics were similar between study groups. As anticipated, atorvastatin was substantially more potent for LDL reduction after 12 months: in the atorvastatin group, LDL cholesterol was 76 23 mg/dL after 12 months (-48.5%); LDL cholesterol was 110 30 mg/dL in the pravastatin group (-27.2%; P<0.001). Atorvastatin induced progressive CIMT regression over 12 months (change in CIMT, -0.034 +/- 0.021 mm), whereas CIMT was stable in the pravastatin group (change of 0.025 +/- 0.017 mm; P=0.03). Conclusions-Marked LDL reduction (<100 mg/dL) with a high-potency statin provides superior efficacy for atherosclerosis regression at 1 year. This early effect on CIMT, a surrogate for clinical benefit, suggests that marked LDL reduction with synthetic statins may provide enhanced reduction in clinical coronary event rates. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Cardiovasc Res Cardiol Serv, 6900 Georgia Ave NW,Bldg 2,Room 4A, Washington, DC 20307 USA. NR 34 TC 377 Z9 396 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 15 PY 2002 VL 106 IS 16 BP 2055 EP 2060 DI 10.1161/01.CIR.0000034508.55617.65 PG 6 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 605NH UT WOS:000178683600008 PM 12379573 ER PT J AU Cropek, DM Kemme, PA Day, JM AF Cropek, DM Kemme, PA Day, JM TI Use of pyrolysis GC/MS for predicting emission byproducts from the incineration of double-base propellant SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID THERMAL-DECOMPOSITION; FUEL-RICH; 1,2-DICHLOROBENZENE; DEGRADATION; MIXTURES; DESTRUCTION; FLAMES; GAS AB Gas chromatography/mass spectrometry was used to analyze the pyrolytic byproducts from an Army-unique propellant compound (AA2) that is composed of predominantly nitrocellulose and nitroglycerin. Compounds produced by AA2 pyrolysis were compared to compounds detected in the gaseous effluent from AA2 incineration. The light permanent gases and most of the higher molecular weight byproducts produced by AA2 incineration are replicated by laboratory pyrolysis on AA2. The reverse case also holds whereby 18 out of 24 high molecular weight AA2 pyrolytic byproducts are found in the incinerator emissions. Poor matching, however, was obtained between the two processes for the volatile, water-soluble species. None of these low molecular weight compounds produced under pyrolytic conditions were detected in the AA2 incinerator samples, likely indicating inefficient capture of these compounds from the effluent stream. Separate pyrolytic degradation of the individual components of AA2 provides evidence that nearly all of the incomplete combustion products detected during incineration originate not from the prevalent energetic ingredients but rather from the minor and trace additives in AA2. In addition, pyrolysis successfully identified the AA2 components capable of surviving the incineration process intact. This work illustrates the potential of bench-scale pyrolysis for predicting incineration behavior. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. Waste Management & Res Ctr, Champaign, IL 61820 USA. RP Cropek, DM (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61822 USA. NR 28 TC 11 Z9 11 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 15 PY 2002 VL 36 IS 20 BP 4346 EP 4351 DI 10.1021/es020758d PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 603VK UT WOS:000178581300019 PM 12387407 ER PT J AU Tenbrock, K Juang, YT Gourley, MF Nambiar, MP Tsokos, GC AF Tenbrock, K Juang, YT Gourley, MF Nambiar, MP Tsokos, GC TI Antisense cyclic adenosine 5 '-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus SO JOURNAL OF IMMUNOLOGY LA English DT Article ID TRANSCRIPTIONAL REPRESSOR ICER; CAMP EARLY REPRESSOR; INCREASED EXPRESSION; THE-180 SITE; LYMPHOCYTES; PROTEIN; GENE; ACTIVATION; MECHANISMS; INFECTION AB The cAMP response element modulator (CREM) has been shown to bind specifically to the -180 site of the IL-2 promoter in vitro. CREM protein is increased in T cells of patients with systemic lupus erythematosus (SLE), and it has been considered responsible for the decreased production of IL-2. In this work we show that transcriptional up-regulation is responsible for the increased CREM protein levels and that CREM binds, to the IL-2 promoter in live SLE T cells. Suppression of the expression of CREM mRNA and protein by an antisense CREM plasmid, which was force expressed in SLE T cells by electroporation, resulted in decreased CREM protein binding to the IL-2 promoter and increased expression of IL-2 mRNA and protein. Our data demonstrate that antisense constructs can be used to effectively eliminate the expression of a transcriptional repressor. This approach can be used therapeutically in conditions where increased production of IL-2 is desired. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Washington Hosp Ctr, Dept Med, Washington, DC 20005 USA. RP Tsokos, GC (reprint author), 503 Robert Grant Ave,Bldg 503,Room 1A32, Silver Spring, MD 20910 USA. FU NIAID NIH HHS [R01 AI 49954] NR 38 TC 62 Z9 65 U1 2 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD OCT 15 PY 2002 VL 169 IS 8 BP 4147 EP 4152 PG 6 WC Immunology SC Immunology GA 602NU UT WOS:000178512000013 PM 12370343 ER PT J AU Libraty, DH Young, PR Pickering, D Endy, TP Kalayanarooj, S Green, S Vaughn, DW Nisalak, A Ennis, FA Rothman, AL AF Libraty, DH Young, PR Pickering, D Endy, TP Kalayanarooj, S Green, S Vaughn, DW Nisalak, A Ennis, FA Rothman, AL TI High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; DISEASE SEVERITY; VIREMIA AB Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (greater than or equal to600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF. C1 Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA. Queen Sirikit Natl Inst Child Hlth, Dept Pediat, Bangkok, Thailand. Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Univ Queensland, Dept Microbiol & Parasitol, Brisbane, Qld, Australia. RP Libraty, DH (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, 55 Lake Ave N, Worcester, MA 01655 USA. RI Young, Paul/A-6176-2010 OI Young, Paul/0000-0002-2040-5190 FU NIAID NIH HHS [AI 34533] NR 15 TC 276 Z9 297 U1 1 U2 17 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 15 PY 2002 VL 186 IS 8 BP 1165 EP 1168 DI 10.1086/343813 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 598YK UT WOS:000178304800016 PM 12355369 ER PT J AU Minyard, CM AF Minyard, CM TI Alamein. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Mt Pleasant, MI USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2002 VL 127 IS 17 BP 83 EP 83 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 602ZF UT WOS:000178533800119 ER PT J AU Minyard, CM AF Minyard, CM TI The battle of Alamein: Turning point, World War II. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Mt Pleasant, MI USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2002 VL 127 IS 17 BP 83 EP 83 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 602ZF UT WOS:000178533800118 ER PT J AU Cohen, SP Larkin, T Fant, GV Oberfoell, R Stojanovic, M AF Cohen, SP Larkin, T Fant, GV Oberfoell, R Stojanovic, M TI Does needle insertion site affect diskography results? A retrospective analysis SO SPINE LA English DT Article DE diskography; low back pain; lumbar disc ID INTERNAL DISC DISRUPTION; LOW-BACK-PAIN; ASYMPTOMATIC SUBJECTS; LUMBAR DISCOGRAPHY; SYMPTOMS; FUSION AB Study Design. A retrospective clinical data analysis was performed. Objectives. To determine the effect of needle insertion site on provocative diskography results, and to ascertain whether performing diskography ipsilaterally to a patient's reported pain leads to a higher rate of false-positives. Summary of Background Data. In certain groups of patients, provocative diskography is associated with a significant false-positive rate, which can lead to misdiagnosis and inappropriate treatment. Although purported by some to be a cause of false-positive diskogram results, the effect of needle insertion site on diskography results has yet to be determined. Methods. The charts of 127 patients who underwent diskography were evaluated to determine the relationship between the location of pain, needle insertion site, and diskography results. Results. Performing diskography on the side ipsilateral to a patient's pain did not result in a higher incidence of positive diskogram results. Conclusion. False-positive diskography results are unlikely to result from performing the procedure on the same side as a patient's reported pain. C1 NYU, Sch Med, Dept Anesthesiol, New York, NY 10016 USA. Walter Reed Army Med Ctr, Pain Management Ctr, Dept Anesthesia, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Massachusetts Gen Hosp, MGH Pain Ctr, Dept Anesthesia & Crit Care, Boston, MA 02114 USA. RP Cohen, SP (reprint author), NYU, Sch Med, Dept Anesthesia, 550 1St Ave, New York, NY 10016 USA. NR 21 TC 15 Z9 17 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 15 PY 2002 VL 27 IS 20 BP 2279 EP 2282 DI 10.1097/01.BRS.0000029259.85120.42 PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 605VH UT WOS:000178697400016 PM 12394907 ER PT J AU Gorbunov, NV Morris, JE Greenberger, JS Thrall, BD AF Gorbunov, NV Morris, JE Greenberger, JS Thrall, BD TI Establishment of a novel clonal murine bone marrow stromal cell line for assessment of p53 responses to genotoxic stress SO TOXICOLOGY LA English DT Article DE p53; reporter vector; bone marrow stromal cells; hydrogen peroxide; UVC light; nitric oxide ID NITRIC-OXIDE; DNA-DAMAGE; GENE-EXPRESSION; MAMMALIAN-CELLS; ACCUMULATION; INDUCTION; TOXICITY; PROTEIN; IRRADIATION; RADIATION AB The p53 protein is widely regarded as an important sensor of genotoxic damage in cells, and mutations in p53 are the most frequent observed in human cancers. Rapid assays for evaluating the potential of a chemical or physical agent to alter the transcriptional regulatory role of p53 may therefore serve as useful tools in toxicological research. In this study, the use of enhanced green fluorescent protein (EGFP) as a live cell reporter to assess the transactivation response of p53 to chemical and physical agents was evaluated. A stable murine bone marrow stromal cell line (D2XRIIGFP24) expressing, EGFP under control of p53 response elements was established. D2XRIIGFP24 cells displayed low constitutive background fluorescence which was significantly enhanced in response to exposure to agents that induced p53 protein levels. Increases in EGFP fluorescence in response to oxidative and nitrosative stress as well as UVC irradiation were dose-dependent, detectable within 3 h of exposure and correlated closely with the amount of p53 protein accumulated within the cell. The results demonstrate the potential for rapid and early detection of p53 transactivation using the EGFP reporter approach and indicate this approach is adaptable to a variety of fluorescent assay techniques and a useful cell model for molecular toxicology research. (C) 2002 Published by Elsevier Science Ireland Ltd. C1 Pacific NW Natl Lab, Richland, WA 99352 USA. Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. RP Gorbunov, NV (reprint author), Walter Reed Army Inst Res, Robert Grant Ave,Bldg 503,Room 1A14, Silver Spring, MD 20910 USA. NR 28 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD OCT 15 PY 2002 VL 179 IS 3 BP 257 EP 266 AR PII S0300-483X(02)00356-6 DI 10.1016/S0300-483X(02)00356-6 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 612HQ UT WOS:000179068700006 PM 12270597 ER PT J AU Henderson, RF Barr, EB Blackwell, WB Clark, CR Conn, CA Kalra, R March, TH Sopori, ML Tesfaigzi, Y Menache, MG Mash, DC AF Henderson, RF Barr, EB Blackwell, WB Clark, CR Conn, CA Kalra, R March, TH Sopori, ML Tesfaigzi, Y Menache, MG Mash, DC TI Response of rats to low levels of sarin SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID MAMMALIAN BRAIN; RECEPTORS; ELECTROENCEPHALOGRAM; LOCALIZATION; SUBTYPES; EXPOSURE; M1; M2 AB The purpose of this study was to determine whether exposure to levels of Sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0, 0.2, or 0.4 mg/m(3) of Sarin for 1 h/day for 1, 5, or 10 days under normal (25degreesC) and heat-stressed (32degreesC) conditions were completed and observations were made at 1 day and 1 month after the exposures. The Sarin exposures had no observed effects on body weight, respiration rate, and minute volume during exposure nor in body temperature and activity during the 30-day recovery period. There was no evidence of cellular changes in brain determined by routine histopathology nor of any increase in apoptosis. Brain mRNA for interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6 was increased in a dose-dependent manner. Autoradiographic studies demonstrated that M1 cholinergic receptor site densities were unchanged at 1 day after repeated exposures with or without heat stress. At 30 days, there was a decrease in M1 receptors in the olfactory tubercle (with and without heat), and, with heat stress, M1 sites also decreased in a dose-dependent manner in the front I cortex, anterior olfactory nucleus, and hippocampus. M3 receptor sites were not affected by Sarin exposure alone. In the presence of heat stress, there was an upregulation in binding site densities in the frontal cortex, olfactory tubercle, anterior nucleus, and striatum immediately after exposure, and these effects persisted at 30 days. Although red blood cell acetylcholinesterase (AChE) was not greatly inhibited by the 1-day exposure, there were 30 and 60% inhibitions after repeated exposures at the low and high doses, respectively. Histochemical staining for AChE demonstrated that Sarin exposure alone reduced AChE in the cerebral cortex, striatum, and olfactory bulb. Sarin exposure under heat stress reduced AChE staining in the hippocampus, an area important for memory function. Thus, repeated exposures under heat-stress conditions, to levels of sarin that would not be noticed clinically, resulted in delayed development of brain alterations in cholinergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. (C) 2002 Elsevier Science (USA). C1 Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Univ Miami, Miami, FL 33101 USA. RP Henderson, RF (reprint author), Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. NR 29 TC 53 Z9 54 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 15 PY 2002 VL 184 IS 2 BP 67 EP 76 DI 10.1006/taap.2002.9495 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 610ZE UT WOS:000178991300001 PM 12408950 ER PT J AU Hoffmann, SC Kampen, RL Amur, S Sharaf, MA Kleiner, DE Hunter, K Swanson, SJ Hale, DA Mannon, RB Blair, PJ Kirk, AD AF Hoffmann, SC Kampen, RL Amur, S Sharaf, MA Kleiner, DE Hunter, K Swanson, SJ Hale, DA Mannon, RB Blair, PJ Kirk, AD TI Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury SO TRANSPLANTATION LA English DT Article ID DELAYED GRAFT FUNCTION; QUANTITATIVE RT-PCR; ACUTE REJECTION; SUBCLINICAL REJECTION; TRANSPLANTED KIDNEYS; ADHESION MOLECULES; GENE-EXPRESSION; UP-REGULATION; BIOPSIES; HYPERTENSION AB Background. Following allotransplantation, renal ischemia-reperfusion (I/R) injury initiates a series of events that provokes counter-adaptive immunity. Though T cells clearly mediate allospecific immunity, the manner in which reperfusion events augment their activation has not been established. In addition, comprehensive analysis of I/R injury in humans has been limited. Methods. To evaluate the earliest events occurring following allograft reperfusion and gain insight into those factors linking reperfusion to alloimmunity, we examined human renal allografts 30 to 60 minutes postreperfusion (n=10) and compared them with allografts with normal function that had resolved their I/R injury insult (>1 month posttransplant, n=6) and to normal kidneys (living donor kidneys before procurement, n=8). Biopsies were processed both for immunohistochemical analysis as well as for transcript analysis by real-time quantitative polymerase chain reaction (RT-PCR). Results. Reperfusion injury was characterized by increased levels of gene transcripts known to be involved in cellular adhesion, chemotaxis, apoptosis, and monocyte recruitment and activation. T-cell-associated transcripts were generally absent. However, recovered allografts exhibited increased levels of T-cell and costimulation-related gene transcripts despite normal allograft function. Consistent with these findings, the immediate postreperfusion state was characterized histologically by tubular injury and monocyte infiltration, while the stable posttransplant state was notable for T-cell infiltration. Conclusions. These data suggest that monocytes and, transcripts related to their recruitment dominate the immediate postreperfusion state. This gives way to a T-cell dominant milieu even in grafts selected for their stable function and absence of rejection. These data have implications for understanding the fundamental link between I/R injury and alloimmunity. C1 NIDDKD, Bethesda, MD 20892 USA. USN, Transplantat & Autoimmun Branch, Bethesda, MD 20084 USA. Appl Biosyst Inc, Foster City, CA 94404 USA. NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. RP Kirk, AD (reprint author), Room 11S-219,Bldg 10,Ctr Dr, Bethesda, MD 20892 USA. RI Kirk, Allan/B-6905-2012; OI Kleiner, David/0000-0003-3442-4453 NR 39 TC 73 Z9 79 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD OCT 15 PY 2002 VL 74 IS 7 BP 916 EP 923 DI 10.1097/01.TP.0000031932.83993.E9 PG 8 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 604WX UT WOS:000178645000003 PM 12394831 ER PT J AU Mackie, DM Prather, DW Shi, SY AF Mackie, DM Prather, DW Shi, SY TI Preoptimization improvements to subwavelength diffractive lenses SO APPLIED OPTICS LA English DT Article ID ELEMENTS; QUANTIZATION; PHASE AB We present preoptimization strategies for improving the design of diffractive lenses in the electromagnetic domain, with few or no electromagnetic analyses. We find that improvements can be substantial, in some cases even to the point that extensive electromagnetic optimization gives only marginal additional improvement. (C) 2002 Optical Society of America. C1 USA, Res Lab, Microphoton Branch, Adelphi, MD 20783 USA. Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP Mackie, DM (reprint author), USA, Res Lab, Microphoton Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dmackie@arl.army.mil NR 11 TC 4 Z9 4 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 10 PY 2002 VL 41 IS 29 BP 6168 EP 6175 DI 10.1364/AO.41.006168 PG 8 WC Optics SC Optics GA 602FM UT WOS:000178495200014 PM 12389985 ER PT J AU Sturm, M Perovich, DK Holmgren, J AF Sturm, M Perovich, DK Holmgren, J TI Thermal conductivity and heat transfer through the snow on the ice of the Beaufort Sea SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE snow; snow cover; Arctic ocean; thermal conductivity; heat flow; sea ice ID MODEL; CLIMATE; COVER AB [1] Eighty-nine point measurements of the thermal conductivity (k(s)) of the snow on the sea ice of the Beaufort Sea were made using a heated needle probe. Average values ranged from 0.078 W m(-1) K-1 for new snow to 0.290 W m(-1) K-1 for an ubiquitous wind slab. ks increased with increasing density, consistent with published equations, but could also be reliably estimated from the metamorphic state of the snow. Using measured values of ks and snow stratigraphy, the average bulk value for the full snowpack was 0.14 W m(-1) K-1. In contrast, ks inferred from ice growth and temperature gradients in the snow was 0.33 W m(-1) K-1. The mismatch arises in part because the second estimate is based on measurements from an aggregate scale that includes enhanced heat flow due to two- and three-dimensional snow and ice geometry. A finite element model suggests that the complex geometry produces areas of concentrated heat loss at the snow surface. These "hot spots,'' however, increase the apparent conductivity only by a factor of 1.4, not enough to fully explain the mismatch. Nonconductive heat transfer mechanisms, like natural and forced air convection, may also be operating in the snowpack, though the ubiquitous presence of low permeability wind slabs potentially limits their effectiveness. The relative contributions of effects due to snow and ice geometric and nonconductive processes within the snowpack remain uncertain. C1 USA, Cold Reg Res & Engn Lab Alaska, Ft Wainwright, AK 99703 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Sturm, M (reprint author), USA, Cold Reg Res & Engn Lab Alaska, POB 35170, Ft Wainwright, AK 99703 USA. NR 46 TC 72 Z9 74 U1 1 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD OCT 10 PY 2002 VL 107 IS C21 AR 8043 DI 10.1029/2000JC000409 PG 17 WC Oceanography SC Oceanography GA 638MF UT WOS:000180574200001 ER PT J AU Gaquere, A Liang, S Hsu, FL Bu, XR AF Gaquere, A Liang, S Hsu, FL Bu, XR TI The readily available tert-pentyl group as a most effective simple directing group for asymmetric synthesis: a case study on Salen-Mn(III)-catalyzed epoxidation SO TETRAHEDRON-ASYMMETRY LA English DT Article ID HIGHLY ENANTIOSELECTIVE EPOXIDATION; CATALYSTS; COMPLEXES; ADDITIONS; OLEFINS; ALDOL AB The tert-pentyl group has been found to produce a pronounced stereodirecting effect, which is manifested in a study on Salen-Mn(III) complexes bearing such groups. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Clark Atlanta Univ, Dept Chem, Atlanta, GA 30314 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bu, XR (reprint author), Clark Atlanta Univ, Dept Chem, Atlanta, GA 30314 USA. EM xbu@cau.edu NR 16 TC 16 Z9 16 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0957-4166 J9 TETRAHEDRON-ASYMMETR JI Tetrahedron: Asymmetry PD OCT 4 PY 2002 VL 13 IS 19 BP 2089 EP 2093 AR PII S0957-4166(02)00582-7 DI 10.1016/S0957-4166(02)00582-7 PG 5 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic; Chemistry, Physical SC Chemistry GA 609RF UT WOS:000178917800005 ER PT J AU Florens, L Washburn, MP Raine, JD Anthony, RM Grainger, M Haynes, JD Moch, JK Muster, N Sacci, JB Tabb, DL Witney, AA Wolters, D Wu, YM Gardner, MJ Holder, AA Sinden, RE Yates, JR Carucci, DJ AF Florens, L Washburn, MP Raine, JD Anthony, RM Grainger, M Haynes, JD Moch, JK Muster, N Sacci, JB Tabb, DL Witney, AA Wolters, D Wu, YM Gardner, MJ Holder, AA Sinden, RE Yates, JR Carucci, DJ TI A proteomic view of the Plasmodium falciparum life cycle SO NATURE LA English DT Article ID MALARIA PARASITE; GENE-EXPRESSION; CHROMOSOMAL DOMAINS; IDENTIFICATION; SEQUENCE; PROTEINS; STAGE; MOSQUITO; TRANSCRIPTOME; ERYTHROCYTES AB The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression. C1 Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA. Syngenta Res & Technol, Dept Proteom & Metabolom, Torrey Mesa Res Inst, San Diego, CA 92121 USA. Univ London Imperial Coll Sci Technol & Med, Infect & Immun Sect, Dept Biol Sci, London SW7 2AZ, England. USN, Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Natl Inst Med Res, Div Parasitol, London NW7 1AA, England. Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. Amer Type Culture Collect, Malaria Res & Reference Resource Ctr, Manassas, VA 20110 USA. Inst Genom Res, Rockville, MD 20850 USA. RP Yates, JR (reprint author), Scripps Res Inst, Dept Cell Biol, SR-11,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM jyates@scripps.edu RI Holder, Anthony/A-7554-2013; Pain, Arnab/L-5766-2015; OI Holder, Anthony/0000-0002-8490-6058; Pain, Arnab/0000-0002-1755-2819; Florens, Laurence/0000-0002-9310-6650; Witney, Adam/0000-0003-4561-7170; Washburn, Michael/0000-0001-7568-2585 FU Medical Research Council [MC_U117532067] NR 45 TC 845 Z9 881 U1 20 U2 139 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD OCT 3 PY 2002 VL 419 IS 6906 BP 520 EP 526 DI 10.1038/nature01107 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 599RF UT WOS:000178348400047 PM 12368866 ER PT J AU Chiaventone, FJ AF Chiaventone, FJ TI Overrated - Underrated - Indian leader (Results of the fifth annual 'American Heritage' survey) SO AMERICAN HERITAGE LA English DT Article C1 US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Chiaventone, FJ (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HERITAGE SUBSCRIPTION DEPT PI NEW YORK PA FORBES BUILDING 60 FIFTH AVE, NEW YORK, NY 10011 USA SN 0002-8738 J9 AM HERITAGE JI Am. Herit. PD OCT PY 2002 VL 53 IS 5 BP 45 EP 46 PG 2 WC History SC History GA 593ZG UT WOS:000178023900021 ER PT J AU Spiller, RJ AF Spiller, RJ TI Overrated - Underrated - World War II general - (Results of the fifth annual 'American Heritage' survey) SO AMERICAN HERITAGE LA English DT Article C1 US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Spiller, RJ (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HERITAGE SUBSCRIPTION DEPT PI NEW YORK PA FORBES BUILDING 60 FIFTH AVE, NEW YORK, NY 10011 USA SN 0002-8738 J9 AM HERITAGE JI Am. Herit. PD OCT PY 2002 VL 53 IS 5 BP 52 EP 52 PG 1 WC History SC History GA 593ZG UT WOS:000178023900032 ER PT J AU Dalton, SR Fillman, EP Altman, CE Gardner, TL Libow, LF Elston, DM AF Dalton, SR Fillman, EP Altman, CE Gardner, TL Libow, LF Elston, DM TI Atypical junctional melanocytic proliferations in "benign lichenoid keratosis." SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT ASCP/CAP Fall National Meeting CY OCT 12, 2002 CL WASHINGTON, D.C. SP ASCP, CAP C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Geisinger Med Ctr, Danville, PA 17822 USA. Cohen Dermatopathol, Newton, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2002 VL 118 IS 4 MA 29 BP 627 EP 627 PG 1 WC Pathology SC Pathology GA 598XT UT WOS:000178302500049 ER PT J AU Boast, DL Kaplan, KJ Henry, MR AF Boast, DL Kaplan, KJ Henry, MR TI Effects of pregnancy on cervical dysplasia: Risks of progression and management implications. SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT ASCP/CAP Fall National Meeting CY OCT 12, 2002 CL WASHINGTON, DC SP ASCP, CAP C1 Univ Maryland, Sch Med, Baltimore, MD 21201 USA. Natl Naval Med Ctr, Walter Reed Army Med Ctr, Dept Pathol, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2002 VL 118 IS 4 MA 61 BP 637 EP 637 PG 1 WC Pathology SC Pathology GA 598XT UT WOS:000178302500081 ER PT J AU Kaplan, KJ Benedict, JB Sandberg, GD Myers, CP Bigott, TR Greenspan, RB AF Kaplan, KJ Benedict, JB Sandberg, GD Myers, CP Bigott, TR Greenspan, RB TI Validation of a Web-based robotic telepathology system for frozen section diagnosis. SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT ASCP/CAP Fall National Meeting CY OCT 12, 2002 CL WASHINGTON, D.C. SP ASCP, CAP C1 Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. Heidelberg Army Hosp, Dept Pathol, Heidelberg, Germany. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2002 VL 118 IS 4 MA 62 BP 637 EP 638 PG 2 WC Pathology SC Pathology GA 598XT UT WOS:000178302500082 ER PT J AU Carlson, KM Reinker, K Person, D Abe, LM Perry, AK Yamaga, KM Marchuk, DA AF Carlson, KM Reinker, K Person, D Abe, LM Perry, AK Yamaga, KM Marchuk, DA TI Identification of a Col2A1 mutation in a Micronesian family with autosomal dominant precocious osteoarthritis. SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract CT 52nd Annual Meeting of the American-Society-of-Human-Genetics CY OCT 15-19, 2002 CL BALTIMORE, MARYLAND SP Amer Soc Human Genet, NICHHD, NCI, NIMH, Affymetrix Inc, Gentra Syst, NIDCD C1 Univ Hawaii, John A Burns Sch Med, Dept Trop Med & Med Microbiol, Honolulu, HI 96822 USA. Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Duke Univ, Med Ctr, Dept Genet, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 2002 VL 71 IS 4 SU S MA 244 BP 212 EP 212 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA 594AC UT WOS:000178025800244 ER PT J AU Ellsworth, DL Ellsworth, RE Deyarmin, B Mittal, V Lubert, S Shriver, CD Somiari, RL AF Ellsworth, DL Ellsworth, RE Deyarmin, B Mittal, V Lubert, S Shriver, CD Somiari, RL TI Loss of heterozygosity in normal tissue adjacent to primary breast carcinomas. SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract CT 52nd Annual Meeting of the American-Society-of-Human-Genetics CY OCT 15-19, 2002 CL BALTIMORE, MARYLAND SP Amer Soc Human Genet, NICHHD, NCI, NIMH, Affymetrix Inc, Gentra Syst, NIDCD C1 Windber Res Inst, Clin Breast Care Project, Windber, PA USA. Walter Reed Army Med Ctr, Clin Breast Care Project Gen Surg Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 2002 VL 71 IS 4 SU S MA 339 BP 230 EP 230 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA 594AC UT WOS:000178025800341 ER PT J AU Ellsworth, RE Shriver, CD Ellsworth, DL Deyarmin, B Mittal, V Lubert, S Somiari, RI AF Ellsworth, RE Shriver, CD Ellsworth, DL Deyarmin, B Mittal, V Lubert, S Somiari, RI TI Loss of hoterozygosity in premalignant lesions and invasive tumors of the breast: examination of 26 commonly deleted chromosomal regions. SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract CT 52nd Annual Meeting of the American-Society-of-Human-Genetics CY OCT 15-19, 2002 CL BALTIMORE, MARYLAND SP Amer Soc Human Genet, NICHHD, NCI, NIMH, Affymetrix Inc, Gentra Syst, NIDCD C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 2002 VL 71 IS 4 SU S MA 417 BP 243 EP 243 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA 594AC UT WOS:000178025800419 ER PT J AU Zhang, J Troendle, JF Yancey, MK AF Zhang, J Troendle, JF Yancey, MK TI Reassessing the labor curve in nulliparous women SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 22nd Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 14-19, 2002 CL NEW ORLEANS, LOUISIANA SP Soc Maternal Fetal Med DE arrest; labor curve; nullipara; protraction; cesarean ID ARREST AB OBJECTIVES: Our purpose was to examine the pattern of labor progression in nulliparous parturients in contemporary obstetric practice. STUDY DESIGN: We extracted detailed labor data from 1329 nulliparous parturients with a term, singleton, vertex fetus of normal birth weight after spontaneous onset of labor, Cesarean deliveries were excluded, We used a repeated-measures regression with a 10th-order polynomial function to discover the average labor curve under contemporary practice. With use of an interval-censored regression with a log normal distribution, we also computed the expected time interval of the cervix to reach the next centimeter, the expected rate of cervical dilation at each phase of labor, and the duration of labor for fetal descent at various stations. RESULTS: Our average labor curve differs markedly from the Friedman curve. The cervix dilated substantially slower in the active phase. It took approximately 5.5 hours from 4 cm to 10 cm, compared with 2.5 hours under the Friedman curve. We observed no deceleration phase. Before 7 cm, no perceivable change in cervical dilation for more than 2 hour was not uncommon. The 5th percentiles of rate of cervical dilation were all below 1 cm per hour. The 95th percentile of time interval for fetal descent from station +1/3 to +2/3 was 3 hours at the second stage. CONCLUSION: Our results suggest that the pattern of labor progression in contemporary practice differs significantly from the Friedman curve. The diagnostic criteria for protraction and arrest disorders of labor may be too stringent in nulliparous women. C1 NICHHD, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, NIH, Bethesda, MD 20892 USA. Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Zhang, J (reprint author), NICHHD, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, NIH, Bldg 6100,Room 7B03, Bethesda, MD 20892 USA. NR 20 TC 128 Z9 143 U1 1 U2 9 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 2002 VL 187 IS 4 BP 824 EP 828 DI 10.1067/mob.2002.127142 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 606AJ UT WOS:000178709300002 PM 12388957 ER PT J AU Zahn, CM Askew, AN Hall, KL Barth, WH AF Zahn, CM Askew, AN Hall, KL Barth, WH TI The significance of hyperkeratosis/parakeratosis on otherwise normal Papanicolaou smears SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE hyperkeratosis; parakeratosis; Papanicolaou smear ID HUMAN PAPILLOMAVIRUS; CONDYLOMATOUS LESIONS; VIRUS-INFECTION; PARAKERATOSIS; CERVIX; HYBRIDIZATION; CYTOLOGY; DNA AB OBJECTIVE: The purpose of this study was to determine whether hyperkeratosis/parakeratosis found on an otherwise normal Papanicolaou smear was associated with abnormalities after comprehensive evaluation. STUDY DESIGN: We conducted a retrospective cohort study of 566 women identified with hyperkeratosis/parakeratosis on Papanicolaou smears from a 7-year period. All women underwent repeat Papanicolaou smear, colposcopy, and biopsy as indicated. Statistical analysis included chi(2) and Fisher exact tests as appropriate. RESULTS: Final abnormal diagnoses included human papillomavirus (HPV) changes (17%), mild dysplasia (5%), and moderate/severe dysplasia (0.4%). We found no carcinomas, Women younger than age 50 years were more likely to have an abnormality (34% vs 19%, relative risk 1.3, 95% Cl 1.1-1.4, P < .001), primarily because of a higher prevalence of HPV changes on the biopsy specimen (21% vs 9%, relative risk 1.3, 95% Cl 1.2-1.5, P < .001). CONCLUSION: Hyperkeratosis/parakeratosis on an otherwise normal Papanicolaou smear is associated with low-grade changes, particularly among reproductive-age women. C1 Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, Lackland AFB, TX 78236 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Zahn, CM (reprint author), Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, Lackland AFB, TX 78236 USA. NR 25 TC 5 Z9 6 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 2002 VL 187 IS 4 BP 997 EP 1001 DI 10.1067/mob.2002.126640 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 606AJ UT WOS:000178709300040 PM 12388995 ER PT J AU Lewis, MD Pavlin, JA Mansfield, JL O'Brien, S Boomsma, LG Elbert, Y Kelley, PW AF Lewis, MD Pavlin, JA Mansfield, JL O'Brien, S Boomsma, LG Elbert, Y Kelley, PW TI Disease outbreak detection system using syndromic data in the greater Washington DC area SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article DE epidemiology; syndrome; military medicine; disease outbreaks; District of Columbia; sentinel surveillance; ambulatory care; information systems AB Background: Many infectious disease outbreaks, including those caused by intentional attacks, may first present insidiously as ill-defined syndromes or unexplained deaths. While there is no substitute for the astute healthcare provider or laboratorian alerting the health department of unusual patient presentations, suspicious patterns may be apparent at the community level well before patient-level data raise an alarm. Methods: Through centralized Department of Defense medical information systems, diagnoses based on International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes are obtained daily from 99 military emergency rooms and primary care clinics across the Washington, DC, region. Similar codes are grouped together in seven diagnostic clusters that represent related presenting signs, symptoms, and diagnoses. Daily monitoring of the data is conducted and evaluated for variation from comparable historic patterns for all seven syndrome groups. Geospatial mapping and trend analysis are performed using geographic information systems software. Data were received on a daily basis beginning in December 1999 and collection continues. The data cut-off date for this manuscript was January 2002. Results: Demographic breakdown of military beneficiaries covered by the surveillance area reveals a broad age, gender, and geographic distribution that is generalizable to the Washington DC region. Ongoing surveillance for the previous 2 years demonstrates expected fluctuations for day-of-the-week and seasonal variations. Detection of several natural disease outbreaks are discussed as well as an analysis of retrospective data from the Centers for Disease Control and Prevention's sentinel physicians-surveillance network during the influenza season that revealed a significantly similar curve to the percentage of patients coded with a respiratory illness in this new surveillance system. Discussion: We believe that this surveillance system can provide early detection of disease outbreaks such as influenza and possibly intentional acts. Early detection should enable officials to quickly focus limited public health resources, decrease subsequent mortality, and improve risk communication. The system is simple, flexible, and, perhaps most critical, acceptable to providers in that it puts no additional requirements on them. C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. Global Emerging Infect Syst, Dept Def, Silver Spring, MD USA. Vector Res Inc, Alexandria, VA USA. USA Ctr Hlth Promot & Prevent Med, Aberdeen, MD USA. RP Lewis, MD (reprint author), USAMC, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 11 TC 80 Z9 91 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD OCT PY 2002 VL 23 IS 3 BP 180 EP 186 AR PII S0749-3797(02)00490-7 DI 10.1016/S0749-3797(02)00490-7 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 599EC UT WOS:000178320300006 PM 12350450 ER PT J AU Baron, RM Palmer, LJ Tantisira, K Gabriel, S Sonna, LA Le, L Hallock, A Libermann, TA Drazen, JM Weiss, ST Silverman, ES AF Baron, RM Palmer, LJ Tantisira, K Gabriel, S Sonna, LA Le, L Hallock, A Libermann, TA Drazen, JM Weiss, ST Silverman, ES TI DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE genetics; population stratification; polymorphism; Tristan da Cunha; transcription factor ID TRANSCRIPTION FACTOR; POPULATION; GENETICS; GENES; DISEQUILIBRIUM; SUBFAMILY AB Epithelium-specific ETS-2 and ETS-3 are transcription factors that have been proposed as asthma candidate genes. To investigate the association of sequence variants in these genes with asthma, we conducted a case-control association analysis in a sample of 311 white subjects with asthma and 177 white subjects without asthma. Common polymorphisms in these genes were detected by sequencing DNA from 32 cell lines obtained from Coriel (Camden, NJ). Seven noncoding or synonymous single-nucleotide polymorphisms were detected: three in epithelium-specific ETS-2 and four in epithelium-specific ETS-3. Subjects were genotyped at all loci by mass spectroscopy. To ensure the suitability of our control subjects, we also genotyped subjects at 49 unlinked polymorphisms evenly distributed throughout the autosomes and found no evidence of population stratification. Logistic regression adjusted for age and sex suggested a weak association of one epithelium-specific ETS-2 polymorphism with asthma diagnosis (odds ratio = 1.89, 95% confidence interval = 1.13-3.18, p = 0.02). Total serum immunoglobulin E and FEV1 predicted levels were not associated with any of the polymorphisms. Extended haplotyping indicated linkage disequilibrium in these genes; however, no association or epistatic interaction was found. This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population. C1 Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. Brigham & Womens Hosp, Div Pulm & Crit Care Med, Channing Lab, Dept Med, Boston, MA 02115 USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, New England Baptist Bone & Joint Inst, Boston, MA 02115 USA. MIT, Whitehead Genome Ctr, Cambridge, MA 02139 USA. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA. RP Silverman, ES (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, 667 Huntington Ave, Boston, MA 02115 USA. RI Libermann, Towia/F-9866-2010; Drazen, Jeffrey/E-5841-2012; Palmer, Lyle/K-3196-2014; OI Palmer, Lyle/0000-0002-1628-3055; Libermann, Towia/0000-0002-4006-8179 FU NHLBI NIH HHS [R01 HL70573, U01 HL065899, UO1 HL65899] NR 25 TC 13 Z9 14 U1 0 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD OCT 1 PY 2002 VL 166 IS 7 BP 927 EP 932 DI 10.1164/rccm.200201-048OC PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 599YJ UT WOS:000178362600008 PM 12359648 ER PT J AU Bui-Mansfield, LT Kaplan, KJ Boardman, J AF Bui-Mansfield, LT Kaplan, KJ Boardman, J TI Radiologic-pathologic conference of Keller Army Community Hospital at West Point, the United States Military Academy - Synovial sarcoma of the chest wall SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID TUMORS C1 Keller Army Community Hosp, Dept Radiol, W Point, NY 10996 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Keller Army Community Hosp, Dept Surg, W Point, NY 10996 USA. RP Bui-Mansfield, LT (reprint author), Keller Army Community Hosp, Dept Radiol, 900 Washington Rd, W Point, NY 10996 USA. NR 4 TC 6 Z9 6 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2002 VL 179 IS 4 AR UNSP 0361-803X/02/1794-880 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 595JD UT WOS:000178104700012 PM 12239029 ER PT J AU Faiz, MA Bin Yunus, E Rahman, MR Hossain, MA Pang, LW Rahman, ME Bhuiyan, SN AF Faiz, MA Bin Yunus, E Rahman, MR Hossain, MA Pang, LW Rahman, ME Bhuiyan, SN TI Failure of national guidelines to diagnose uncomplicated malaria in Bangladesh SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB During the mid 1990s, national guidelines were established in accordance with World Health Organization recommendations for the diagnosis of uncomplicated malaria in Bangladesh. Based on simple clinical and epidemiologic criteria these guidelines were designed to be applied outside of tertiary care centers where microscopy was not feasible. We evaluated the positive predictive value (PPV) of these criteria using microscopic slide examinations as the gold standard in 684 subjects diagnosed and treated for malaria, sampling from eight subdistrict centers. The PPV for malaria was 32% with 19% for falciparum and 14% for Plasmodium vivax. Medical officers assigned to the study also gave their own clinical impression of whether cases could have been malaria. With the additional criteria of a medical officers' diagnosis, the PPV increased negligibly to 37% with 23% and 14% for falciparum and vivax, respectively. Since the PPV of diagnosis is low and cannot be improved on clinical grounds alone, we recommend the incorporation of laboratory diagnosis. This is especially important as we detect resistance to the first-line therapy chloroquine and require more expensive, potentially more toxic, regimens. C1 Chittagong Med Coll, Malaria Res Grp, Chittagong 4000, Bangladesh. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Faiz, MA (reprint author), Chittagong Med Coll, Malaria Res Grp, Chittagong 4000, Bangladesh. NR 10 TC 12 Z9 12 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2002 VL 67 IS 4 BP 396 EP 399 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 613EP UT WOS:000179119400013 PM 12452493 ER PT J AU Stojadinovic, A Shoup, M Nissan, A Ghossein, RA Shah, JP Brennan, MF Shaha, AR AF Stojadinovic, A Shoup, M Nissan, A Ghossein, RA Shah, JP Brennan, MF Shaha, AR TI Recurrent differentiated thyroid carcinoma: Biological implications of age, method of detection, and site and extent of recurrence SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE thyroid; carcinoma; recurrence; outcome ID HURTHLE CELL-CARCINOMA; SERUM THYROGLOBULIN; CANCER; THERAPY; I-131; MANAGEMENT; METASTASES; SURGERY AB Background: We identified factors predictive of outcome for recurrent differentiated thyroid carcinoma (DTC). Methods: Fifty-seven patients with local (LR), regional (RRec), and/or distant recurrence (DR) of 431 recurrent DTCs were studied. Disease-specific survival (DSS) rate was estimated with the Kaplan-Meier method. Univariate and multivariate comparisons were conducted by log-rank and Cox regression analysis. Results: The median follow-up was 13 years. Distribution of the first relapse was LR only (35%), LR and RRec (23%), LR and DR (30%), and LR, RRec, and DR (12%). Factors predictive of resectability were a long ( greater than or equal to5-year) disease-free interval (DFI) and subclinical and thyroid remnant recurrence. Only 26% of symptomatic and 45% of thyroid bed LR, and 43% with DFI <5 years, could be resected completely. No isolated thyroid remnant and 75% of thyroid bed LR resulted in tumor-related mortality. Age <45 years, subclinical recurrence, isolated LR, and the ability to render the patient disease free independently predicted DSS. Fifteen-year DSS for LR only; LR and RRec; LR and DR; and LR, RRec, and DR were 49%, 28%, 15%, and 0%, respectively. Conclusions: Isolated thyroid remnant recurrence defines a benign phenotype. Age, method of detection, site and extent of recurrence, and the ability to render the patient disease free predict outcome for recurrent DTC. Multimodality long-term follow-up is warranted to detect recurrence at a subclinical potentially curative stage. C1 Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA. Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Gen Surg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. OI Brennan, Murray/0000-0003-2358-4371; Shah, Jatin/0000-0002-6444-6592 NR 21 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD OCT PY 2002 VL 9 IS 8 BP 789 EP 798 DI 10.1245/ASO.2002.02.001 PG 10 WC Oncology; Surgery SC Oncology; Surgery GA 601NJ UT WOS:000178452400014 PM 12374663 ER PT J AU Durlach, PJ Elliman, NA Rogers, PJ AF Durlach, PJ Elliman, NA Rogers, PJ TI Drinking while thirsty can lead to conditioned increases in consumption SO APPETITE LA English DT Article ID HIGH DIETARY-FAT; FLAVOR PREFERENCES; YOUNG-CHILDREN; FOOD; DEPRIVATION; SELECTION; CAFFEINE; STATE AB A within-subject design was used to test whether repeatedly drinking a novel-flavoured and coloured drink while thirsty would influence subsequent liking for or consumption of that drink, compared to a different flavoured and coloured drink repeatedly consumed while less thirsty. Each participant was given 300 ml of one flavoured drink (H) after consuming a high salt meal (5.27 g of salt), and 300 ml of another flavoured drink (L) after consuming a low salt meal (1.27 g of salt). Participants had 4 sessions with each meal-type/drink combination, in an intermixed order. Pre- and post-training assessments of the drinks were conducted to determine the impact of the training regime on pleasantness and perceived thirst-quenching effect of the drinks. The final session included a choice test, and ad libitum access to the chosen drink, after either a high or low salt meal. In this final choice session, people drank almost twice as much H as L; however, there were no differential effects of past training on rated liking or choice. The increased consumption of H might reflect greater liking for H which was not detected by the rating scales; or it might reflect the learning of greater "conditioned thirst" in response to the flavour of H. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Army Res Inst, Simulator Syst Res Unit, Orlando, FL 32826 USA. Aston Univ, Dept Psychol, Birmingham B4 7ET, W Midlands, England. Univ Bristol, Dept Expt Psychol, Bristol, Avon, England. RP Durlach, PJ (reprint author), Army Res Inst, Simulator Syst Res Unit, 12350 Res Pkwy, Orlando, FL 32826 USA. NR 26 TC 9 Z9 9 U1 1 U2 5 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD OCT PY 2002 VL 39 IS 2 BP 119 EP 125 DI 10.1006/appe.2002.0493 PG 7 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 600WQ UT WOS:000178415100002 PM 12354680 ER PT J AU Merrill, EP Kramer, FM Cardello, A Schutz, H AF Merrill, EP Kramer, FM Cardello, A Schutz, H TI A comparison of satiety measures SO APPETITE LA English DT Article ID FOODS C1 USA, Natick Soldier Syst Ctr, Behav Sci Div, Natick, MA 01670 USA. RP Merrill, EP (reprint author), USA, Natick Soldier Syst Ctr, Behav Sci Div, Natick, MA 01670 USA. NR 9 TC 25 Z9 26 U1 1 U2 7 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD OCT PY 2002 VL 39 IS 2 BP 181 EP 183 DI 10.1006/appe.2002.0496 PG 3 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 600WQ UT WOS:000178415100010 PM 12354688 ER PT J AU Golash, RG Dworkin, MS AF Golash, RG Dworkin, MS TI Coping with the anthrax threat at the state level - Public health officials in Illinois activated plans, enhanced communication, took other steps to keep pace with testing surge SO ASM NEWS LA English DT Article C1 Illinois Dept Publ Hlth, Special Bacteriol & Bioterrorism Unit, Springfield, IL 62761 USA. USA, Lab Serv, Combat Support Hosp 801st, Ft Sheridan, IL USA. No Illinois Univ, De Kalb, IL 60115 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0044-7897 J9 ASM NEWS JI ASM News PD OCT PY 2002 VL 68 IS 10 BP 494 EP 498 PG 5 WC Microbiology SC Microbiology GA 602NM UT WOS:000178511400010 ER PT J AU Power, ED Duma, SM Stitzel, JD Herring, IP West, RL Bass, CR Crowley, JS Brozoski, FT AF Power, ED Duma, SM Stitzel, JD Herring, IP West, RL Bass, CR Crowley, JS Brozoski, FT TI Computer modeling of airbag-induced ocular injury in pilots wearing night vision goggles SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE eye; ocular injuries; night vision goggles; finite element analysis ID HUMAN CORNEA; SIMULATION; EYE AB Background: Airbags have saved lives in automobile crashes for many years and are now planned for use in helicopters. The purpose of this study was to investigate the potential for ocular injuries to helicopter pilots wearing night vision goggles when the airbag is deployed. Methods: A nonlinear finite element model of the human eye was created. Ocular structures such as the fatty tissue, extraocular muscles, and bony orbit were included. The model was imported into Madymo (Mathematical Dynamical Models) and used to determine the worst-case position of a helicopter pilot wearing night vision goggles. This was evaluated as the greatest Von Mises stress in the eye when the airbag was deployed. Results: The worst-case position was achieved by minimizing the distance between the eyes and goggles, having the occupant look directly into the airbag, and making initial contact with the airbag halfway through its full deployment. Simulations with the goggles both remaining fastened to and breaking away from the aviator helmet were performed. Finally, placing a protective lens in front of the eyes was found to reduce the stress to the eye but increase the force experienced by the surrounding orbital bones. Conclusion: The finite element model of the eye proved effective for evaluating the experimental parameters. C1 Virginia Polytech Inst & State Univ, Impact Biomech Lab, Blacksburg, VA 24061 USA. Univ Virginia, Automobile Safety Lab, Charlottesville, VA USA. USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Duma, SM (reprint author), Virginia Polytech Inst & State Univ, Impact Biomech Lab, 114 Randolph Hall, Blacksburg, VA 24061 USA. RI Duma, Stefan/A-8368-2012; Stitzel Jr, Joel/B-4045-2012; Herring, Ian/S-5421-2016 OI Herring, Ian/0000-0002-3493-5969 NR 25 TC 16 Z9 16 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2002 VL 73 IS 10 BP 1000 EP 1006 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 600NP UT WOS:000178397500008 PM 12398263 ER PT J AU Balkin, TJ Braun, AR Wesensten, NJ Jeffries, K Varga, M Baldwin, P Belenky, G Herscovitch, P AF Balkin, TJ Braun, AR Wesensten, NJ Jeffries, K Varga, M Baldwin, P Belenky, G Herscovitch, P TI The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness SO BRAIN LA English DT Article DE alertness; consciousness; sleep inertia; rCBF; PET ID SLEEP INERTIA; PERFORMANCE; CORTEX AB Awakening from sleep entails rapid re-establishment of consciousness followed by the relatively slow (20-30 min later) re-establishment of alertness-a temporal dissociation that facilitates specification of the physiological underpinnings of each of these facets of the awakening process. (H2O)-O-15 PET was used to assess changes in regional cerebral blood flow (rCBF) upon awakening from stage 2 sleep. Cerebral blood flow (CBF) was most rapidly re-established in centrencephalic regions (e.g. brainstem and thalamus), suggesting that the reactivation of these regions underlies the reestablishment of conscious awareness. Across the ensuing 15 min of wakefulness, further increases in CBF were evident primarily in anterior cortical regions, suggesting that the dissipation of sleep inertia effects (postawakening performance and alertness deficits) is effected by reactivation of these regions. Concomitant shifts in correlation patterns of regional brain activity across the post-awakening period [in particular, a waning negative correlation between prefrontal cortex and mesencephalic reticular formation (RF) activity, and a waxing positive correlation between prefrontal cortex and ventromedial caudate nucleus (CAUD) activity] suggest that the post-awakening reversal of sleep inertia effects may be mediated by more than mere reactivation-it may also involve the functional reorganization of brain activity. Conversely, stable post-awakening correlations-such as those found between the anterior cingulate cortex (ACC) and most other brain regions-may denote the pattern of functional connectivity that underlies consciousness itself. C1 Walter Reed Army Inst Res, Dept Behav Biol, Washington, DC 20307 USA. NIDCD, Language Sect, Voice Speech & Language Branch, NIH, Bethesda, MD USA. NIDCD, PET Imaging Sect, NIH, Bethesda, MD USA. RP Balkin, TJ (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Washington, DC 20307 USA. NR 20 TC 120 Z9 130 U1 1 U2 16 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-8950 J9 BRAIN JI Brain PD OCT PY 2002 VL 125 BP 2308 EP 2319 DI 10.1093/brain/awf228 PN 10 PG 12 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 604HR UT WOS:000178613700013 PM 12244087 ER PT J AU Woll, M Fisher, C McLeod, D Shriver, C Ponniah, S George, P AF Woll, M Fisher, C McLeod, D Shriver, C Ponniah, S George, P TI Immunologic monitoring of breast and prostate cancer patients receiving a preventive HER2/neu peptidevaccine. SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Meeting Abstract CT Conference on Frontiers in Cancer Prevention Research CY OCT 14-18, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Canc Res C1 Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Ctr Prostate Dis Res & Vaccine Dev Lab, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD OCT PY 2002 VL 11 IS 10 MA C119 BP 1196S EP 1197S PN 2 PG 2 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 604RE UT WOS:000178634200223 ER PT J AU Felt, DR Larson, SL Valente, EJ AF Felt, DR Larson, SL Valente, EJ TI UV-VIS spectroscopy of 2,4,6-trinitrotoluene-hydroxide reaction SO CHEMOSPHERE LA English DT Article DE explosives; base-induced transformation; kinetics; remediation; principal component analysis; spectrometry ID HIGHLY CONTAMINATED SOILS; ALKALINE-HYDROLYSIS; TNT; DEGRADATION; TRANSFORMATION; KINETICS; PLANT AB Contamination of groundwater, surface water and soil by explosives has occurred at military sites throughout the world as a result of manufacture of explosive compounds, assembly of munitions, and deployment of explosives containing devices. Due to the adverse effects of explosives on humans and other natural receptors, a low cost means of decontaminating these areas of contamination is needed. Base-induced transformation of explosives has shown promise as a rapid, low cost, and minimally resource-intensive technology for detoxifying explosives in soil and water. In order to understand the reaction mechanism, a reaction mixture of 2:1:1 (water:2,4,6-trinitrotoluene (TNT):1 N KOH) was analyzed by UV/VIS spectrometry from 190 to 1100 nm. Time course measurements were conducted at 25, 20, 15, and 12 degreesC. A factor analysis program was used to analyze the spectral data. Principal component analysis indicated that six principal components explained the spectra to within experimental error, with four factors explaining the majority of the variance. Test spectral vectors for four components were developed, including TNT, two intermediates, and the final product, and were tested against the abstract vectors. Two possible reaction mechanisms were suggested and tested to explain the spectral data. Crown Copyright (C) 2002 Published by Elsevier Science Ltd. All rights reserved. C1 Appl Res Assoc, So Div, Vicksburg, MS 39180 USA. USA, Erdc, Vicksburg, MS 39180 USA. Mississippi Coll, Dept Chem & Biochem, Clinton, MS 39058 USA. RP Felt, DR (reprint author), Appl Res Assoc, So Div, 112 Monument Pl, Vicksburg, MS 39180 USA. EM dfelt@ara.com NR 24 TC 16 Z9 16 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2002 VL 49 IS 3 BP 287 EP 295 AR PII S0045-6535(02)00283-7 DI 10.1016/S0045-6535(02)00283-7 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 595QE UT WOS:000178119600008 PM 12363307 ER PT J AU Westblad, C Levendis, YA Richter, H Howard, JB Carlson, J AF Westblad, C Levendis, YA Richter, H Howard, JB Carlson, J TI A study on toxic organic emissions from batch combustion of styrene SO CHEMOSPHERE LA English DT Article DE styrene; polystyrene; combustion; emissions; PAH; kinetics ID AROMATIC HYDROCARBON; POLYSTYRENE; SOOT; POLY(STYRENE); PARTICLES; PVC; POLY(ETHYLENE); TEMPERATURES; PLASTICS; WASTE AB Results from a laboratory-scale investigation on batch combustion of styrene are reported herein. Limited quantities of waste styrene monomer are incinerated, however this monomer is, also, the primary pyrolyzate during combustion of waste polystyrene, the second most abundant polymer produced worldwide. Thus, its combustion-generated emissions are of importance to the operation of hazardous waste incinerators and municipal waste-to-energy powerplants. This work focuses on emissions of polycyclic aromatic hydrocarbons (PAHs), particulates, as well as carbon monoxide. To investigate methods for minimizing such emissions, batch combustion of the monomer was conducted in a two-stage muffle furnace. An additional air mixing chamber was installed between the two stages. Small quantities of the liquid monomer were inserted in the primary furnace which served as a gasifier/burner. The furnace temperature was in the range of 300-1000 degreesC and diffusion flames were formed under most conditions. Upon mixing with additional air, combustion of unburned gaseous fuel and primary reaction products continued in the secondary furnace (afterburner), which was kept at a constant temperature of either 1000 or 800 degreesC. Using this technique, conditions that minimize emissions were explored and theoretical investigations on the fate of pollutants in the secondary furnace were undertaken. Results revealed that combustion of styrene, which is a highly volatile fuel, occurred with the formation of flames that were often non-anchored, unsteady and unstable. Emissions of organic pollutants, soot and CO were more intense than in the case of the polystyrene combustion, studied previously under identical conditions, due to the additional depolymerization/pyrolysis steps therein. The emissions from the secondary furnace exceeded those of the primary furnace, consistent with the fact that a very significant fraction of the fuel conversion occurred in the secondary chamber. Clear trends in the emissions of PAHs and soot, products of incomplete combustion, with the temperature of the primary furnace (gasifier) were observed. Emissions were drastically reduced with lowering the gasifier temperature. While final cumulative emissions of PAHs and soot accounted for more than one third of the mass of the fuel at high temperatures, their concentrations at the exit of the afterburner were negligible when the primary furnace was operated at 300 degreesC under pyrolytic conditions, In the latter case air was added to the afterburner. Numerical modeling based on a complex reaction network was used for the description of the primary furnace as well as of the afterburner. Kinetic analysis showed acetylene and benzene to be key species in the growth of PAHs. Formation of PAHs in the afterburner, found experimentally, was reproduced by the model using a plug-flow assumption. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Northeastern Univ, Coll Engn, Snell Engn Ctr 334, Boston, MA 02115 USA. Linkoping Inst Technol, S-58183 Linkoping, Sweden. MIT, Cambridge, MA 02139 USA. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Coll Engn, Snell Engn Ctr 334, Boston, MA 02115 USA. NR 34 TC 13 Z9 13 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2002 VL 49 IS 4 BP 395 EP 412 AR PII S0045-6535(02)00311-9 DI 10.1016/S0045-6535(02)00311-9 PG 18 WC Environmental Sciences SC Environmental Sciences & Ecology GA 595QH UT WOS:000178119900005 PM 12365837 ER PT J AU Leavitt, WT Armitage, DT AF Leavitt, WT Armitage, DT TI The forensic role of the child psychiatrist in child abuse and neglect cases SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID FOSTER-CARE; PROGRAM AB Child abuse and neglect are immense problems that vex the United States legal and mental health systems. In its effort to meet the challenges of child abuse and neglect, the legal system may turn to child psychiatrists to shed light on the needs of children, parents, and family. The courts have no effective means to develop a sophisticated understanding of abusive family relationships and the needs of children without consulting child psychiatrists. In this forensic arena, child psychiatrists can demonstrate their expertise in useful ways and gamer respect for the profession. Although psychiatrists know their role and are at ease in clinical settings, many do not have much experience in forensic matters. Entry into the legal arena for the uninitiated can be bewildering at best. The goal of this article is to help child psychiatrists along the road to becoming more knowledgeable about, and comfortable functioning within, the subset of the legal system that deals with child abuse and neglect. C1 Walter Reed Army Med Ctr, Forens Psychiat Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. US Army Phys Disabil Agcy, Washington, DC 20307 USA. RP Leavitt, WT (reprint author), Walter Reed Army Med Ctr, Forens Psychiat Serv, Washington, DC 20307 USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 1056-4993 J9 CHILD ADOL PSYCH CL JI Child Adolesc. Psychiatr. N. Am. PD OCT PY 2002 VL 11 IS 4 BP 767 EP + AR PII S1056-4993(02)00029-9 DI 10.1016/S1056-4993(02)00029-9 PG 14 WC Psychiatry SC Psychiatry GA 607CN UT WOS:000178773600009 PM 12397898 ER PT J AU Kolavic-Gray, SA Binn, LN Sanchez, JL Cersovsky, SB Polyak, CS Mitchell-Raymundo, F Asher, LV Vaughn, DW Feighner, BH Innis, BL AF Kolavic-Gray, SA Binn, LN Sanchez, JL Cersovsky, SB Polyak, CS Mitchell-Raymundo, F Asher, LV Vaughn, DW Feighner, BH Innis, BL TI Large epidemic of adenovirus type 4 infection among military trainees: Epidemiological, clinical, and laboratory studies SO CLINICAL INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the Infectious-Diseases-Society-of-America CY NOV 18-21, 1999 CL PHILADELPHIA, PENNSYLVANIA SP Infect Dis Soc Amer ID ACUTE RESPIRATORY-DISEASE; US-ARMY TRAINEES; OUTBREAK; PNEUMONIA; VACCINES; ADULT AB Outbreaks of adenovirus type 4 (Ad4) acute respiratory disease (ARD) have reemerged among US military personnel during the past decade. A prospective epidemiological investigation of 678 military recruits was conducted at Fort Jackson, South Carolina, in the fall of 1998; 115 (17%) of the recruits were hospitalized for febrile ARD. Adenovirus types 4, 3, and 21 were recovered from the cultures of 70 (72%), 7 (7%), and 2 (2%) of 97 recruits, respectively. In addition, 69 (83%) of the 83 hospitalized and 82 (49%) of the 166 nonhospitalized unit contacts had seroconversion to Ad4, which indicates the very high susceptibility and communicability of Ad4 among military recruits. Young age (<20 years) and male sex increased the risk for anti-Ad4 seroconversion. Recruits from tropical areas had higher preexisting immunity than did recruits from temperate regions. Military recruits are highly susceptible to Ad4 infections. Prompt reinstitution of an adenovirus vaccination program in this high-risk population is urgently C1 USA, Ctr Hlth Promot & Prevent Med, Epidemiol Serv Program, Aberdeen Proving Ground, MD USA. Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. RP Sanchez, JL (reprint author), USN, Med Res Ctr Detachment Lima, Unit 3800, APO, AA 34031 USA. NR 41 TC 71 Z9 72 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 1 PY 2002 VL 35 IS 7 BP 808 EP 818 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 594DF UT WOS:000178032900005 PM 12228817 ER PT J AU Macedonia, M AF Macedonia, M TI The computer graphics wars heat up SO COMPUTER LA English DT Article C1 USA, Simulat Training & Instrumentat Command, Orlando, FL USA. RP Macedonia, M (reprint author), USA, Simulat Training & Instrumentat Command, Orlando, FL USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 J9 COMPUTER JI Computer PD OCT PY 2002 VL 35 IS 10 BP 97 EP 99 DI 10.1109/MC.2002.1039523 PG 3 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA 598XB UT WOS:000178300800022 ER PT J AU Rogers-Bennett, L Haaker, PL Karpov, KA Kushner, DJ AF Rogers-Bennett, L Haaker, PL Karpov, KA Kushner, DJ TI Using spatially explicit data to evaluate marine protected areas for abalone in southern California SO CONSERVATION BIOLOGY LA English DT Article ID RED ABALONE; NORTHERN CALIFORNIA; HARVEST REFUGIA; WHITE ABALONE; HALIOTIS; RESERVES; POPULATIONS; MANAGEMENT; ABUNDANCE; PACIFIC AB Abalone populations have declined dramatically in southern California. The white abalone (Haliotis sorenseni) is now (2001) on the federal endangered species list. To aid in the restoration of white, pink (H. corrugata), and green abalone (H. fulgens), productive marine protected areas need to be selected. We used spatially explicit fishery data (1950-1995) to identify the most productive marine areas in southern California. To assess the role of existing marine protected areas we compared fishery-independent data (1983-2001) inside protected and fished areas. San Clemente Island produced the greatest cumulative catches of white, pink, and green abalone, the most white abalone per hectare of deep reef (25-65 m), and the most green abalone per kilometer of rocky shoreline. Santa Barbara Island, however, produced 10 times more pink abalone per hectare of kelp canopy, making this area an excellent candidate for restoration and protection. Pink abalone surveyed in the Kelp Forest Monitoring Program were most abundant at three sites surrounding Anacapa Island: (1) protected, (2) protected but less visible, and (3) fished. The protected sites, despite having lower abundances of pink abalone initially (1983), had significantly more abalone (H=9.0; df=2; p=0.011) than the nearby fished site over time. Size-frequency distributions revealed that the protected site had more (30%) commercial-size abalone (greater than or equal to158 mm shell length) than the less visable site (6%) or the fished site (2%). Mean size was significantly larger at the protected site, yielding the highest estimate of biomass and potential egg production (2555 million eggs/site/year) of all the sites. Marine protected areas need to be selected and enforced so that abalone-restoration efforts can be enacted before remnant populations die. Restoration sites for a wide variety of depleted species can be selected based on previous levels of productivity identified by spatially explicit data. C1 Univ Calif Santa Cruz, Inst Marine Sci, Calif Dept Fish & Game, Bodega Bay, CA 94923 USA. Bodega Bay Marine Lab, Bodega Bay, CA 94923 USA. Calif Dept Fish & Game, Los Alamitos, CA 90720 USA. Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. Channel Isl Natl Pk, Sugitani, Toyama 93001, Japan. RP Rogers-Bennett, L (reprint author), Univ Calif Santa Cruz, Inst Marine Sci, Calif Dept Fish & Game, POB 247, Bodega Bay, CA 94923 USA. NR 47 TC 19 Z9 19 U1 1 U2 21 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0888-8892 J9 CONSERV BIOL JI Conserv. Biol. PD OCT PY 2002 VL 16 IS 5 BP 1308 EP 1317 DI 10.1046/j.1523-1739.2002.01002.x PG 10 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 596UC UT WOS:000178183600017 ER PT J AU Johnson, K Pearce, F Westenskow, D Ogden, LL Farnsworth, S Peterson, S White, J Slade, T AF Johnson, K Pearce, F Westenskow, D Ogden, LL Farnsworth, S Peterson, S White, J Slade, T TI Clinical evaluation of the life support for trauma and transport (LSTAT (TM)) platform SO CRITICAL CARE LA English DT Article DE medical devices; patient simulations; transportation of patients ID CRITICALLY ILL PATIENTS; INTRAHOSPITAL TRANSPORT AB Introduction The Life Support for Trauma and Transport (LSTAT(TM)) is a self-contained, stretcher-based miniature intensive care unit designed by the United States Army to provide care for critically injured patients during transport and in remote settings where resources are limited. The LSTAT contains conventional medical equipment that has been integrated into one platform and reduced in size to fit within the dimensional envelope of a North Atlantic Treaty Organization (NATO) stretcher. This study evaluated the clinical utility of the LSTAT in simulated and real clinical environments. Our hypothesis was that the LSTAT would be equivalent to conventional equipment in detecting and treating life-threatening problems. Methods Thirty-one anesthesiologists and recovery room nurses compared the LSTAT with conventional monitors while managing four simulated critical events. The time required to reach a diagnosis and treatment was recorded for each simulation. Subsequently, 10 consenting adult patients were placed on the LSTAT after surgery for postoperative care in the recovery room. Questionnaires about aspects of LSTAT functionality were completed by nine nurses who cared for the patients placed on the LSTAT. Results In all of the simulations, there was no clinically significant difference in the time to diagnosis or treatment between the LSTAT and conventional equipment. All clinicians reported that they were able to manage the simulated patients properly with the LSTAT. Nursing staff reported that the LSTAT provided adequate equipment to care for the patients monitored during recovery from surgery and were able to detect critical changes in vital signs in a timely manner. Discussion Preliminary evaluation of the LSTAT in simulated and postoperative environments demonstrated that the LSTAT provided appropriate equipment to detect and manage critical events in patient care. Further work in assessing LSTAT functionality in a higher-acuity environment is warranted. C1 Univ Utah, Sch Med, Dept Anesthesiol, Salt Lake City, UT 84112 USA. Walter Reed Army Inst Res, Div Mil Casualty Res, UWHA, Dept Resuscitat Med, Silver Spring, MD USA. Univ Utah, Sch Med, Dept Biomed Engn, Salt Lake City, UT USA. RP Johnson, K (reprint author), Univ Utah, Sch Med, Dept Anesthesiol, Salt Lake City, UT 84112 USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PD OCT PY 2002 VL 6 IS 5 BP 439 EP 446 DI 10.1186/cc1538 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 600AM UT WOS:000178368500017 PM 12398785 ER PT J AU Elmer, KB Elston, DM Libow, LF AF Elmer, KB Elston, DM Libow, LF TI Trichosporon beigelii infection presenting as white piedra and onychomycosis in the same patient SO CUTIS LA English DT Article ID SUSCEPTIBILITY; THERAPY AB Trichosporon beigelii is a fungal organism that causes white piedra and has occasionally been implicated as a nail pathogen. We describe a patient with both hair and nail changes associated with T beigelii. C1 Brooke Army Med Ctr, Dept Dermatol, San Antonio, TX USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17822 USA. NR 17 TC 11 Z9 12 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD OCT PY 2002 VL 70 IS 4 BP 209 EP 211 PG 3 WC Dermatology SC Dermatology GA 605RK UT WOS:000178690700003 PM 12403311 ER PT J AU McCleskey, PE Erickson, QL David-Bajar, KM Elston, DM AF McCleskey, PE Erickson, QL David-Bajar, KM Elston, DM TI Palmar petechiae in dermatitis herpetiformis: A case report and clinical review SO CUTIS LA English DT Article ID TISSUE TRANSGLUTAMINASE; CELIAC-DISEASE; METALLOELASTASE MMP-12; EXPRESSION; ANTIBODIES; AUTOANTIBODIES; MALIGNANCY AB Palmar petechiae or purpura is an unusual finding in dermatitis herpetiformis (DH) that occurs in children but is only rarely reported in adults. We describe a 46-year-old man with DH who presented with the classic pruritic papulovesicular eruption and associated volar finger and palmar petechiae. We discuss recent advances in the pathogenesis and treatment of DH. C1 David Grant Med Ctr, Fairfield, CA USA. Brooke Army Med Ctr, Dept Dermatol, San Antonio, TX USA. San Antonio Uniformed Serv, Hlth Educ Consortium, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78284 USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17822 USA. NR 38 TC 6 Z9 6 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD OCT PY 2002 VL 70 IS 4 BP 217 EP 223 PG 7 WC Dermatology SC Dermatology GA 605RK UT WOS:000178690700005 PM 12403313 ER PT J AU Barfield, RL Barrett, KR Moon, CM David-Bajar, K AF Barfield, RL Barrett, KR Moon, CM David-Bajar, K TI Pruritic linear papules on a 75-year-old woman: A case of localized Darier-White disease SO CUTIS LA English DT Article ID DYSKERATOTIC EPIDERMAL NEVUS; FEATURES AB Darier-White disease (DWD), commonly called Darier disease or keratosis follicularis, is a genodermatosis seen in clinical practice. It exists more commonly in the generalized form but can present as a localized condition. Localized DWD is a rare entity characterized by epidermal changes that are like those seen in the generalized form but that are confined to a small area of skin. This entity is postulated to result from a postzygotic mutation and has the potential to be transmitted to offspring, which may result in the severe generalized form. We report a case of localized DWD diagnosed after biopsy of a recalcitrant linear dermatitis and discuss the salient features of this condition. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. San Antonio Uniformed Serv Hlth Educ Consortium, Dept Dermatol, Ft Sam Houston, TX USA. RP Barfield, RL (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 14 TC 8 Z9 8 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD OCT PY 2002 VL 70 IS 4 BP 225 EP 228 PG 4 WC Dermatology SC Dermatology GA 605RK UT WOS:000178690700006 PM 12403314 ER PT J AU Albertini, JG Welsch, MJ Conger, LA Libow, LF Elston, DM AF Albertini, JG Welsch, MJ Conger, LA Libow, LF Elston, DM TI Infantile digital fibroma treated with Mohs micrographic surgery SO DERMATOLOGIC SURGERY LA English DT Editorial Material AB BACKGROUND. Infantile digital fibroma (IDF) is a rare benign fibrous tumor of childhood that frequently recurs despite local excision. Conservative, nonsurgical management may result in regression and/or joint deformity. OBJECTIVE. To describe the histologic features of IDF and discuss a case excised using Mobs micrographic surgery (MMS). METHODS. Case report and review of the clinical, histologic, and ultrastructural features. RESULTS. Characteristic inclusion bodies of actin were identified with hematoxylin and eosin, Masson's trichrome, and rapid actin immunostain. The tumor was debulked and the majority was removed after one stage of MMS, except where the deep margin approached the joint space. The defect healed by secondary intention. At 2 years the patient had no recurrence or functional joint deformity. CONCLUSION. MMS is a surgical treatment option for IDF. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Darnall Army Community Hosp, Ft Hood, TX USA. RP Albertini, JG (reprint author), Skin Surg Ctr, 125 Sunny Knoll Ct,Suite 100, Winston Salem, NC 27106 USA. NR 14 TC 12 Z9 13 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD OCT PY 2002 VL 28 IS 10 BP 959 EP 961 DI 10.1046/j.1524-4725.2002.02072.x PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA 606PD UT WOS:000178741600014 PM 12410684 ER PT J AU Parysow, P Tazik, DJ AF Parysow, P Tazik, DJ TI Assessing the effect of estimation error on population viability analysis: an example using the black-capped vireo SO ECOLOGICAL MODELLING LA English DT Article DE conservation biology; population viability analysis; black-capped vireo; endangered species; neotropical migrant; estimation error; uncertainty; VORTEX ID CONSERVATION BIOLOGY; SPECIES MANAGEMENT; EXTINCTION; MODELS; STOCHASTICITY; UNCERTAINTY; DYNAMICS; VORTEX; ALEX AB Population viability analysis (PVA) is usually conducted assuming that values of factors that characterize both average conditions and natural variability (stochasticity) are error-free. However, those values are often estimates of true parameters and, therefore, have an associated estimation error. This error, also called uncertainty, arises from limitations of the methods used to estimate parameter values, such as sampling, measurement, and expert opinion error. Natural resource management decisions must be made in spite of incomplete information, and the impact of uncertainty when establishing specific management objectives must be assessed. We propose a strategy to reflect our current degree of knowledge about stochastic and average system conditions by accounting for error in parameter estimates of PVA models and assessing its effect on establishing endangered species conservation objectives. Using the computer simulation model VORTEX, we applied this strategy to the black-capped vireo (Vireo atricapillus), an endangered neotropical migrant land bird species. We pursued two conservation goals in this study: probability of persistence and retention of genetic diversity of at least 95 and 90%, respectively, over the next 100 years. We evaluated two situations, one accounting for uncertainty, the other not. Achieving the conservation goals while explicitly accounting for estimate uncertainty required more demanding management objectives than that assuming no uncertainty. Under static carrying capacity, we had to increase fecundity 40% from 2.5 to 3.5 young fledged per female per year to meet the conservation goals. Explicitly incorporating estimation error into PVA allows us not only to assess the range of possible fates an endangered species may face, but also to establish measures necessary for meeting the conservation goals despite current levels of uncertainty. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. USA, Construct Engn Res Labs, Nat Resources Assessement & Management Div, Champaign, IL 61826 USA. RP Parysow, P (reprint author), No Arizona Univ, Sch Forestry, POB 15018, Flagstaff, AZ 86011 USA. EM pablo.parysow@nau.edu NR 58 TC 10 Z9 13 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD OCT 1 PY 2002 VL 155 IS 2-3 BP 217 EP 229 AR PII S0304-3800(02)00146-1 DI 10.1016/S0304-3800(02)00146-1 PG 13 WC Ecology SC Environmental Sciences & Ecology GA 601YW UT WOS:000178477900008 ER PT J AU De, BK Bragg, SL Sanden, GN Wilson, KE Diem, LA Marston, CK Hoffmaster, AR Barnett, GA Weyant, RS Abshire, TG Ezzell, JW Popovic, T AF De, BK Bragg, SL Sanden, GN Wilson, KE Diem, LA Marston, CK Hoffmaster, AR Barnett, GA Weyant, RS Abshire, TG Ezzell, JW Popovic, T TI Two-component direct fluorescent-antibody assay for rapid identification Bacillus anthracis SO EMERGING INFECTIOUS DISEASES LA English DT Article ID BIOLOGICAL WARFARE; S-LAYER; BIOTERRORISM; ANTIGENS; CAPSULE AB A two-component direct fluorescent-antibody (DFA) assay, using fluorescein-labeled monoclonal antibodies specific to the Bacillus anthracis cell wall (CW-DFA) and capsule (CAP-DFA) antigens, was evaluated and validated for rapid identification of B. anthracis. We analyzed 230 B. anthracis isolates; 228 and 229 were positive by CW-DFA and CAP-DFA assays, respectively. We also tested 56 non-B. anthracis strains; 10 B. cereus and 2 B. thuringiensis were positive by the CW-DFA assay, and 1 B. megaterium strain was positive by CAP-DFA. Analysis of the combined DFA results identified 227 of 230 B. anthracis isolates; all 56 strains of the other Bacillus spp. were negative. Both DFA assays tested positive on 14 of 26 aging clinical specimens from the 2001 anthrax outbreak investigation. The two-component DFA assay is a sensitive, specific, and rapid confirmatory test for B. anthracis in cultures and may be useful directly on clinical specimens. C1 Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. USA, Med Inst Infect Dis, Ft Detrick, MD USA. RP De, BK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Mailstop G34,1600 Clifton Rd NE, Atlanta, GA 30333 USA. NR 22 TC 46 Z9 48 U1 0 U2 2 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2002 VL 8 IS 10 BP 1060 EP 1065 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 605AL UT WOS:000178653200010 PM 12396916 ER PT J AU Krinitzsky, EL AF Krinitzsky, EL TI Epistematic and aleatory uncertainty: a new shtick for probabilistic seismic hazard analysis SO ENGINEERING GEOLOGY LA English DT Article ID EARTHQUAKE PROBABILITY; RECURRENCE C1 Corps Engineers, Geotech Lab, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Krinitzsky, EL (reprint author), Corps Engineers, Geotech Lab, Engn Res & Dev Ctr, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 7 TC 9 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD OCT PY 2002 VL 66 IS 1-2 BP 157 EP 159 AR PII S0013-7952(02)00029-7 DI 10.1016/S0013-7952(02)00029-7 PG 3 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 604TQ UT WOS:000178637500011 ER PT J AU Cole, CA Shafer, D AF Cole, CA Shafer, D TI Section 404 wetland mitigation and permit success criteria in Pennsylvania, USA, 1986-1999 SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE mitigation; Pennsylvania; permits; Section 404; success criteria; wetland creation ID FRESH-WATER WETLANDS; ECOSYSTEM PROCESSES; AREA; RESTORATION; DIVERSITY; PORTLAND; OREGON; BAY AB Twenty-three Section 404 permits in central Pennsylvania (covering a wetland age range of 1-14 years) were examined to determine the type of mitigation wetland permitted, how the sites were built, and what success criteria were used for evaluation. Most permits allowed for mitigation out-of-kind, either vegetatively or through hydrogeomorphic class. The mitigation process has resulted in a shift from impacted wetlands dominated by woody species to less vegetated mitigation wetlands, a trend that appears to be occurring nationwide, An estimate of the percent cover of emergent vegetation was the only success criterion specified in the majority of permits. About 60% of the mitigation wetlands were judged as meeting their originally defined success criteria, some after more than 10 years, The permit process appears to have resulted in a net gain of almost 0.05 ha of wetlands per mitigation project. However, due to the replacement of emergent, scrub-shrub, and forested wetlands with open water ponds or uplands, mitigation practices probably led to a net loss of vegetated wetlands. C1 Penn State Univ, Ctr Watershed Stewardship, University Pk, PA 16801 USA. USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cole, CA (reprint author), Penn State Univ, Ctr Watershed Stewardship, 227 E Calder Way, University Pk, PA 16801 USA. NR 31 TC 30 Z9 31 U1 0 U2 11 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD OCT PY 2002 VL 30 IS 4 BP 508 EP 515 DI 10.1007/s00267-002-2717-4 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 590NW UT WOS:000177829800005 PM 12481917 ER PT J AU Ravikrishna, R Yost, SL Price, CB Valsaraj, KT Brannon, JM Miyares, PH AF Ravikrishna, R Yost, SL Price, CB Valsaraj, KT Brannon, JM Miyares, PH TI Vapor phase transport of unexploded ordnance compounds through soils SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE unexploded ordnance; volatilization; partition constants ID ADSORPTION AB Unexploded ordnance (UXO) is a source of concern at several U.S. Department of Defense (DOD) sites. Localization of munitions and fate and transport of the explosive compounds from these munitions are a major issue of concern. A set of laboratory experiments were conducted in specially designed flux chambers to measure the evaporative flux of three explosive compounds (2,4-dinitrotoluene, 2,6-dinitrotoluene, and 1,3-dinitrobenzene) from three different soils. The effect of different soil moisture contents, the relative humidity of air contacting the soils surface, and soil temperature on the chemical fluxes were evaluated. A diffusion model was used to describe the chemical transport mechanism in the soil pore air. The soil-air partition constant was treated as a fit parameter in the model because of the uncertainty in the a priori estimation. The model predicts the qualitative trends of the experimental fluxes satisfactorily. Under extremely dry conditions, the flux decreased more rapidly than that predicted by the model. The fluxes from soils at 24degreesC were higher than those at 14degreesC, indicating a larger volatilization driving force at the higher temperature. C1 Louisiana State Univ, Gordon A & Mary Cain Dept Chem Engn, Baton Rouge, LA 70803 USA. DynTel Corp, Vicksburg, MS 39180 USA. USA, Corps Engineers, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Valsaraj, KT (reprint author), Louisiana State Univ, Gordon A & Mary Cain Dept Chem Engn, Baton Rouge, LA 70803 USA. NR 14 TC 7 Z9 7 U1 0 U2 2 PU SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2002 VL 21 IS 10 BP 2020 EP 2026 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 596FJ UT WOS:000178153300003 PM 12371476 ER PT J AU Miles, MP Kraemer, WJ Grove, DS Leach, SK Dohi, K Bush, JA Marx, JO Nindl, BC Volek, JS Mastro, AM AF Miles, MP Kraemer, WJ Grove, DS Leach, SK Dohi, K Bush, JA Marx, JO Nindl, BC Volek, JS Mastro, AM TI Effects of resistance training on resting immune parameters in women SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE resistance training; natural killer cells; B cells; T cells; lymphocyte proliferation ID STRENGTH; EXERCISE AB The aim of this investigation was to determine whether intense resistance training of 6 months duration influenced resting immune parameters. Previously untrained women underwent one of four training programs or were non-training controls (CON, n = 7). The resistance-training groups trained for total body power (TP, n = 16), total body hypertrophy (TH, n = 18), upper body power (UP, n 15) or upper body hypertrophy (UH, n = 15). Immune parameters were measured from a fasting morning blood draw in September/October (0 months, t(0)), November/December (3 months, t(3)), and April/May (6 months, t(6)). Lymphocyte subsets [CD4+ T cells, CD8+ T cells, natural killer cells (NK), and B cells], and mitogen-stimulated proliferation were measured. The concentration of NK cells increased (P < 0.001) after 3 months of training for the resistance-training groups but not the CON group. This increase was not present after 6 months of training, thus it was a transient change. Lymphocyte proliferation responses were similar across time for the resistance-trained and CON groups for all stimulation conditions. Thus, resistance training induces a transient increase in NK cells but has little effect on lymphocyte trafficking or proliferation. This was consistent despite differences in the volume of muscle mass trained or the manner of training (power verses hypertrophy). C1 Montana State Univ, Dept Hlth & Human Dev, Bozeman, MT 59717 USA. Penn State Univ, Dept Biochem & Mol Biol, State Coll, PA USA. Penn State Univ, Dept Kinesiol, Lab Sports Med, State Coll, PA USA. Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT USA. USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Miles, MP (reprint author), Montana State Univ, Dept Hlth & Human Dev, Bozeman, MT 59717 USA. OI Mastro, Andrea/0000-0003-2710-3360 FU NCRR NIH HHS [M01-RR-10732] NR 8 TC 11 Z9 12 U1 0 U2 3 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD OCT PY 2002 VL 87 IS 6 BP 506 EP 508 DI 10.1007/s00421-002-0683-4 PG 3 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 608DW UT WOS:000178830700005 PM 12355189 ER PT J AU Wirth, M Iversen, P McLeod, D See, W AF Wirth, M Iversen, P McLeod, D See, W TI Immediate therapy in early prostate cancer: Results from the bicalutamide ('Casodex') EPC Programme SO EUROPEAN UROLOGY SUPPLEMENTS LA English DT Article; Proceedings Paper CT Conference on Prostate Cancer - Life after Diagnosis CY NOV 29-30, 2001 CL NICE, FRANCE DE prostate cancer; standard care; Early Prostate Cancer Programme; bicalutamide; 'Casodex' ID RADICAL PROSTATECTOMY; CAPSURE DATABASE; CARCINOMA; SURVIVAL; BENEFIT; TRIAL AB The Early Prostate Cancer (EPC) Programme was designed to evaluate the efficacy and tolerability of bicalutamide ('Casodex') 150 mg in addition to standard care (radical prostatectomy, radiotherapy, or watchful waiting) in patients with early stage prostate cancer. A total of 8113 men with localised or locally advanced prostate cancer and negative bone scans were recruited. Patients were randomised to receive either bicalutamide 150 mg per day (n = 4052) or placebo (n = 4061) once daily, in addition to standard care. The primary endpoints for the programme are time to objectively confirmed progression and overall survival. Secondary endpoints include time to doubling of prostate-specific antigen (PSA) and tolerability. The tolerability profile of bicalutamide 150 mg was closely related to its pharmacology, with gynaecomastia (66%) and breast pain (73%) the most frequently reported adverse events. The majority of the gynaecomastia (70%) and breast pain (90%) events improved or resolved following withdrawal from therapy. Bicalutamide 150 mg significantly reduced the risk of objective progression by 42% (p much less than 0.0001) compared with standard care alone. This effect was seen in patients with localised disease (28% reduction; p < 0.001) and locally advanced disease (54% reduction; p < 0.001), and was also seen regardless of the type of standard care received. In addition, bicalutamide 150 mg plus standard care reduced the risk of PSA doubling by 59% (p much less than 0.0001), and the incidence of bone metastases by 33% (p < 0.0001), compared with patients receiving placebo plus standard care. After a median follow-up of 3 years, there was no significant difference in overall survival between the treatment groups (p = 0.43); however, both progression and survival continue to be followed in these ongoing studies. In conclusion, immediate bicalutamide 150 mg treatment, either alone or as an adjuvant to treatment of curative intent, significantly reduces the risk of disease progression in patients with localised or locally advanced prostate cancer. (C) 2002 Published by Elsevier Science B.V. C1 Tech Univ Dresden, Dept Urol, D-01307 Dresden, Germany. Univ Copenhagen, Rigshosp, Dept Urol, DK-2100 Copenhagen, Denmark. New Hosp, Walter Reed Army Med Ctr, Urol Serv, Washington, DC USA. Med Coll Wisconsin, Div Urol, Milwaukee, WI 53226 USA. RP Wirth, M (reprint author), Tech Univ Dresden, Dept Urol, Fetscherstasse 74, D-01307 Dresden, Germany. NR 18 TC 3 Z9 3 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1569-9056 J9 EUR UROL SUPPL JI Eur. Urol. Suppl. PD OCT PY 2002 VL 1 IS 7 BP 20 EP 25 AR PII S1569-9056(02)00083-0 DI 10.1016/S1569-9056(02)00083-0 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 626NB UT WOS:000179878100005 ER PT J AU McClean, MD Tasko, SM AF McClean, MD Tasko, SM TI Association of orofacial with laryngeal and respiratory motor output during speech SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE speech motor coordination; jaw; lips; tongue; laryngeal; respiratory; human ID MIDBRAIN PERIAQUEDUCTAL GRAY; ARTICULATORY DYNAMICS; MOVEMENT VELOCITY; VOCAL INTENSITY; MUSCLE-ACTIVITY; VOCALIZATION; LIP; COORDINATION; MODULATIONS; SENSITIVITY AB Speech motor coordination most likely involves synaptic coupling among neural systems that innervate orofacial, laryngeal, and respiratory muscles. The nature and strength of coupling of the orofacial with the respiratory and laryngeal systems was studied indirectly by correlating orofacial speeds with fundamental frequency, vocal intensity, and inspiratory volume during speech. Fourteen adult subjects repeated a simple test utterance at varying rates and vocal intensities while recordings were obtained of the acoustic signal and movements of the upper lip, lower lip, tongue, jaw, rib cage, and abdomen. Across subjects and orofacial speed measures (14 subjects x 4 structures), significant correlations were obtained for fundamental frequency in 42 of 56 cases, for intensity in 35 of 56 cases, and for inspiratory volume in 14 of 56 cases. These results suggest that during speech production there is significant neural coupling of orofacial muscle systems with the laryngeal and respiratory systems as they are involved in vocalization. Comparisons across the four orofacial structures revealed higher correlations for the jaw relative to other orofacial structures. This suggests stronger connectivity between neural systems linking the jaw with the laryngeal and respiratory systems. This finding may be relevant to the frame/content theory of speech production, which suggests that the neural circuitry involved in jaw motor control for speech has evolved to form relatively strong linkages with systems involved in vocalization. C1 Western Michigan Univ, Dept Speech Pathol & Audiol, Kalamazoo, MI 49008 USA. Walter Reed Army Med Ctr, Audiol & Speech Ctr, Washington, DC 20307 USA. RP McClean, MD (reprint author), Western Michigan Univ, Dept Speech Pathol & Audiol, Kalamazoo, MI 49008 USA. NR 38 TC 26 Z9 27 U1 0 U2 2 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0014-4819 J9 EXP BRAIN RES JI Exp. Brain Res. PD OCT PY 2002 VL 146 IS 4 BP 481 EP 489 DI 10.1007/s00221-002-1187-5 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 606RP UT WOS:000178747200009 PM 12355277 ER PT J AU Tuorila, H Cardello, AV AF Tuorila, H Cardello, AV TI Consumer responses to an off-flavor in juice in the presence of specific health claims SO FOOD QUALITY AND PREFERENCE LA English DT Article; Proceedings Paper CT 4th Pangborn Sensory Science Symposium 2001: A Sense Odyssey CY JUL 22-26, 2001 CL DIJON, FRANCE DE hedonic responses; functional foods; health claim; off-flavor; likelihood of consumption ID INFORMATION; FOOD AB Adult US subjects (n = 78) tasted and rated three juice samples containing 0, 0.3, and 0.6% KCI blind and informed. Three subgroups were informed that the juices contained functional ingredients to improve either (1) physical endurance and energy (2) mental alertness and memory, or (3) mood and emotional well-being. A control group received no information. Degree of liking and likelihood of consuming the juice once, twice or four times a day, for a total of four or 16 times, were rated. Adulteration with KCI decreased all ratings of liking, while information about health benefits increased ratings of liking in subgroups 1 and 2. Likelihood of consumption decreased with increasing KCI, with the increasing number of times per day, and with total dose regimen. The data suggest that the consumption of a functional food will be inversely related to the severity of off-flavor and to the required frequency and duration of consumption. No support was found for the notion that a slight off-flavor is a positive marker of health benefits to consumers. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Univ Helsinki, Dept Food Technol, FIN-00014 Helsinki, Finland. USA, Natick Soldier Ctr, Natick, MA 01760 USA. RP Tuorila, H (reprint author), Univ Helsinki, Dept Food Technol, POB 27, FIN-00014 Helsinki, Finland. NR 24 TC 164 Z9 170 U1 3 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD OCT-DEC PY 2002 VL 13 IS 7-8 BP 561 EP 569 AR PII S0950-3293(01)00076-3 DI 10.1016/S0950-3293(01)00076-3 PG 9 WC Food Science & Technology SC Food Science & Technology GA 617VQ UT WOS:000179381900016 ER PT J AU Moody, H Basting, A Cole, T Ray, R Woodward, K Butler, R AF Moody, H Basting, A Cole, T Ray, R Woodward, K Butler, R TI Memoir and autobiography in later life SO GERONTOLOGIST LA English DT Meeting Abstract C1 USA, Int Longev Ctr, New York, NY 10021 USA. Hunter Coll, Brookdale Ctr Aging, New York, NY USA. Inst Med Humanities, Galveston, TX USA. Gerontol Ctr, Detroit, MI USA. Univ Washington, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GERONTOLOGICAL SOCIETY AMER PI WASHINGTON PA 1275 K STREET NW SUITE 350, WASHINGTON, DC 20005-4006 USA SN 0016-9013 J9 GERONTOLOGIST JI Gerontologist PD OCT PY 2002 VL 42 SI 1 BP 246 EP 247 PG 2 WC Gerontology SC Geriatrics & Gerontology GA 620PH UT WOS:000179541400873 ER PT J AU Carlson, N Winter, WE Krivak, TC Crothers, B Macri, C Carlson, JW AF Carlson, N Winter, WE Krivak, TC Crothers, B Macri, C Carlson, JW TI Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections SO GYNECOLOGIC ONCOLOGY LA English DT Article DE placental site trophoblastic tumor; gestational trophoblastic disease; chemotherapy ID CHEMOTHERAPY; PSEUDOTUMOR; EXPERIENCE; RECURRENT; REMISSION; UTERUS AB Introduction. Placental site trophoblastic tumor (PSTT) is an uncommon variant of gestational trophoblastic disease. Most of these tumors are confined to the uterus and treated with a simple hysterectomy. However, 30% of these patients will present with metastatic disease. These patients are typically treated with a hysterectomy followed by adjuvant multiagent chemotherapy. Unfortunately, PSTT is relatively resistant to chemotherapy when compared to other forms of gestational trophoblastic disease. Consequently, these patients have a poor prognosis. Case. We present a case report of a 26-year-old female with multiple metastatic lesions to the lungs unresponsive to chemotherapy who was managed with multiple pulmonary resections. She has remained clinically free of disease at 28 months of follow up. Conclusion. A patient with metastatic PSTT was successfully managed with radical surgical resection of chemotherapy-resistant sites. (C) 2002 Elsevier Science (USA). C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Natl Naval Med Res Inst, Dept Obstet & Gynecol, Bethesda, MD 20889 USA. RP Carlson, JW (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jay.carlson@na.amedd.army.mil NR 14 TC 9 Z9 13 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2002 VL 87 IS 1 BP 146 EP 149 DI 10.1006/gyno.2002.6776 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 605QN UT WOS:000178688700023 PM 12468357 ER PT J AU Sjogren, MH Holtzmuller, K Smith, M Sjogren, R AF Sjogren, MH Holtzmuller, K Smith, M Sjogren, R TI Sustained antiviral response with consensus interferon (CIFN)plus ribavirin or interferon alfa-2b (IFN alfa-2b) plus ribavirin in treatment-naive subjects with chronic hepatitis C. A pilot study. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Kaiser Permanente, Mid Atlantic State, Falls Church, VA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 593 BP 311A EP 311A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301700575 ER PT J AU Esmat, G Abouzied, AM Abdel-Aziz, F Mohamed, MK Abdel-Hamid, M El Raziky, MS Ismail, SA Zalata, KR Mikhail, NN Fix, A Strickland, T Sjogren, MH AF Esmat, G Abouzied, AM Abdel-Aziz, F Mohamed, MK Abdel-Hamid, M El Raziky, MS Ismail, SA Zalata, KR Mikhail, NN Fix, A Strickland, T Sjogren, MH TI Treatment with Peg-Interferon alfa-2b (PEG-IFN) plus ribavirin compared to interferon alfa-2b (INF alfa-2b)plus ribavirin on subjects with chronic hepatitis C infected with HCV genotype 4. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Inst Trop Med, Cairo, Egypt. Univ Maryland, Baltimore, MD 21201 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 803 BP 364A EP 364A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301700786 ER PT J AU Harrison, SA Fincke, C Helinski, D Torgerson, S AF Harrison, SA Fincke, C Helinski, D Torgerson, S TI Orlistat treatment in obese, non-alcoholic steatohepatitis patients. A pilot study. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 971 BP 406A EP 406A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301700953 ER PT J AU Hayashi, PH Harrison, S Torgerson, S Nochajski, T Russell, M AF Hayashi, PH Harrison, S Torgerson, S Nochajski, T Russell, M TI Cognitive lifetime drinking history in non-alcoholic fatty liver disease: Some cases may be alcohol related. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Prevent Res Ctr, Berkeley, CA USA. Res Inst Addict, Buffalo, NY 14203 USA. Brooke Army Med Ctr, San Antonio, TX USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 994 BP 411A EP 411A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301700976 ER PT J AU Esmat, G Zakaria, S Khatab, H Abdel-Hamid, M Anwar, M El-Razki, M El-Daly, M El-Kafrawy, S Hasan, A Shaheen, A Abouzied, A Sjogren, MH AF Esmat, G Zakaria, S Khatab, H Abdel-Hamid, M Anwar, M El-Razki, M El-Daly, M El-Kafrawy, S Hasan, A Shaheen, A Abouzied, A Sjogren, MH TI Impact of hepatitis C virus (HCV) genotype and viral load on the biochemical and histopathological liver profiles in Egyptian patients infected with HCV. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Natl Hepatol & Trop Med Res Inst, Cairo, Egypt. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RI El-Daly, Mai/C-4704-2013; El-Kafrawy, Sherif/C-8699-2012 OI El-Kafrawy, Sherif/0000-0002-3667-7529 NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1488 BP 535A EP 535A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701471 ER PT J AU Holtzmuller, KC Frizzell, E Fileta, B Nicholson, D Lewin-Smith, M Ladich, E Rabin, L Specht, C Sjogren, MH Mullick, FG AF Holtzmuller, KC Frizzell, E Fileta, B Nicholson, D Lewin-Smith, M Ladich, E Rabin, L Specht, C Sjogren, MH Mullick, FG TI The timing of hepatitis C seroconversion in a cohort of United States military Gulf War veterans (GWVS). SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1562 BP 553A EP 553A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701544 ER PT J AU Lawitz, EJ Nader, P Cox, J Diamond, K Ganeshappa, KP Reddy, G Lindner, M Nguyen, T Vemuru, R Cantu, NS AF Lawitz, EJ Nader, P Cox, J Diamond, K Ganeshappa, KP Reddy, G Lindner, M Nguyen, T Vemuru, R Cantu, NS TI Daily combination therapy in treatment naive and previous nonresponders with chronic hepatitis C. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Gastroenterol & Hepatol, Seattle, WA USA. Brooke Army Med Ctr, ALAMO Study Grp, San Antonio, TX USA. Texas Digest Dis Consultants, Flower Mound, TX USA. M Broward PA, Tamarac, FL USA. Digest Dis Ctr S Texas, San Antonio, TX USA. San Antonio Gastroenterol, San Antonio, TX USA. GI Associates Houston, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1670 BP 580A EP 580A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701652 ER PT J AU Lawitz, EJ Adams, F Davis, M Fein, S Sperling, R Glombicki, AP Tsai, N Gasic, A Kothari, T Ganeshappa, KP Cox, J Sanders, B Jeffries, M Kadakia, S Buckelew, D Silverman, B Ghandour, E Medoff, J AF Lawitz, EJ Adams, F Davis, M Fein, S Sperling, R Glombicki, AP Tsai, N Gasic, A Kothari, T Ganeshappa, KP Cox, J Sanders, B Jeffries, M Kadakia, S Buckelew, D Silverman, B Ghandour, E Medoff, J TI Triple therapy compared to standard pegylated interferon alfa 2b+weight based ribavirin for treatment naive patients with chronic hepatitis C: 24 week viral clearance (tri-star trial). SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, San Antonio, TX USA. Austin Consultants Gastroenterol, Austin, TX USA. S Florida Ctr Gastroenterol, W Palm Beach, FL USA. Digest Hlth Ctr, Pasadena, TX USA. Houston Digest Dis Consultants, Houston, TX USA. St Francis Med Ctr, Honolulu, HI USA. Longview Gastroenterol Clin, Longview, TX USA. Digest Dis Ctr S Texas, San Antonio, TX USA. Texas Digest Dis Consultants, Flower Mound, TX USA. N Texas Gastroenterol Consultants, Lewisville, TX USA. Inst Gastroenterol & Liver Dis, San Antonio, TX USA. E Texas Gastroenterol, Longview, TX USA. Gastroenterol Associates, NE Olympia, WA USA. Medoff Med, ALAMO Study Grp, Greensboro, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1668 BP 580A EP 580A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701651 ER PT J AU Lawitz, EJ Adams, F Davis, M Fein, S Sperling, R Glombicki, A Tsai, N Gasic, A Kothari, T Ganeshappa, KP Cox, J Sanders, B Silverman, B Ghandour, E Jeff, M Jeffries, M Kadakia, S Buckelew, D AF Lawitz, EJ Adams, F Davis, M Fein, S Sperling, R Glombicki, A Tsai, N Gasic, A Kothari, T Ganeshappa, KP Cox, J Sanders, B Silverman, B Ghandour, E Jeff, M Jeffries, M Kadakia, S Buckelew, D CA ALAMO Study Grp TI Triple therapy compared to standard pegylated interferon alfa 2b plus weight based ribavirin in previous interferon based therapy nonresponders and relapsers. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, San Antonio, TX USA. Austin Consultants Gastro, Austin, TX USA. S Florida Ctr Gastroenterol, W Palm Beach, FL USA. Digest Hlth Ctr, Pasadena, TX USA. Houston Digest, Houston, TX USA. SFMC Liver Ctr, Honolulu, HI USA. LGV Gastroenterol, Longview, TX USA. Gastroenterol Associates, Rochester, NY USA. Digest Dis Ctr S Texas, San Antonio, TX USA. Texas Digest Dis Consultants, Flower Mound, TX USA. N TX GI Consultants, Lewisville, TX USA. Gastroenterol Associates NE Olympia, Olympia, WA USA. Gastroenterol Associates, Lubbock, TX USA. Medoff Med, Greensboro, NC USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. McGraner Kadakia Med, San Antonio, TX USA. E Texas Gastroenterol, ALAMO Study Grp, Longview, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1674 BP 581A EP 581A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701656 ER PT J AU Lawitz, EJ Cantu, NS Lapeer, MG Dalton, CA AF Lawitz, EJ Cantu, NS Lapeer, MG Dalton, CA TI Interleukin-11 in patients with chronic hepatitis C with advanced liver disease who have been nonresponsive to antiviral therapy SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1672 BP 581A EP 581A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701655 ER PT J AU Lawitz, EJ Cantu, NS LaPeer, MG Matossian, H Buckelew, D James, D Jolley, J Bilir, B Li, JJ Warfield, P Galen, E Ganeshappa, KP AF Lawitz, EJ Cantu, NS LaPeer, MG Matossian, H Buckelew, D James, D Jolley, J Bilir, B Li, JJ Warfield, P Galen, E Ganeshappa, KP CA ALAMO Study Grp TI Daily combination therapy is superior to standard combination therapy: Final analysis. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, San Antonio, TX USA. E Texas Gastroenterol, Longview, TX USA. Gastro United Tulsa, Tulsa, OK USA. Univ Florida, Hlth Sci Ctr, Jacksonville, FL 32209 USA. Lexington Clin Gastroenterol, Lexington, KY USA. NW GI Clin, Portland, OR USA. Digest Dis Ctr S Texas, ALAMO Study Grp, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1673 BP 581A EP 581A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701654 ER PT J AU Hepburn, MJ Lawitz, EJ AF Hepburn, MJ Lawitz, EJ TI Immunologic markers in hepatitis C infection and their relationship to combination therapy. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1770 BP 605A EP 605A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701752 ER PT J AU Hepburn, MJ Lawitz, EJ Torgerson, S AF Hepburn, MJ Lawitz, EJ Torgerson, S TI Hepatic steatosis in hepatitis C patients: Steatosis decreases with combination therapy. SO HEPATOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 01-05, 2002 CL BOSTON, MASSACHUSETTS SP Amer Assoc Study Liver Dis C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2002 VL 36 IS 4 SU S MA 1769 BP 605A EP 605A PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 598XK UT WOS:000178301701750 ER PT J AU Burton, WH Farrar, JS Steimle, F Conlin, B AF Burton, WH Farrar, JS Steimle, F Conlin, B TI Assessment of out-of-kind mitigation success of an artificial reef deployed in Delaware Bay, USA SO ICES JOURNAL OF MARINE SCIENCE LA English DT Article; Proceedings Paper CT 7th International Conference on Artificial Reefs and related Aquatic Habitats CY OCT 07-11, 1999 CL SAN REMO, ITALY SP ICES, Italian Soc Marine Biol, European Artificial Reef Res Network, Sanremo Congressi Turismo, Univ Geona, Phillips Petr, European Commiss, US Natl Marine Fisheries Serv DE benthic secondary production epifauna; estuarine artificial reef; mitigation AB An out-of-kind, off-site mitigation reef was constructed in 1989 to replace an oligohaline tidal marsh and subtidal mudflat of the upper Delaware Estuary that had been filled in 1985 to create the Wilmington Harbor South Dredged Material Disposal Area. Habitat loss consisted of 57.4 ha of subtidal, soft-bottom habitat. The mitigation reef (0.651 ha of surface area) consisted of 16 prefabricated concrete reef structures, arranged in four clusters of four units each, near Brown's Shoal in Delaware Bay. We estimated benthic secondary production of the two sites using published production: biomass ratios (P:B) as a tool for conducting comparisons of benthic epifaunal communities. Results indicate that the artificial reef provides enhanced benthic secondary production per unit area (2000-12000 kcal yr(-1)) over the lost habitat (177 kcal yr(-1)), but that total production (3 and 77 million kcal yr(-1)) does not equal what has been lost (100 million kcal/yr). The construction of this reef, while not completely effective in its intended mitigation, provides a benchmark by which to design and judge future mitigation efforts. (C) 2002 International Council for the Exploration of the Sea. Published by Elsevier Science Ltd. All rights reserved. C1 Versar Inc, Columbia, MD 21045 USA. Natl Marine Fisheries Serv, Highlands, NJ 07732 USA. US Dept Army, Corps Engineers, Philadelphia, PA 19107 USA. RP Burton, WH (reprint author), Versar Inc, 9200 Rumsey Rd, Columbia, MD 21045 USA. NR 20 TC 5 Z9 5 U1 2 U2 6 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1054-3139 J9 ICES J MAR SCI JI ICES J. Mar. Sci. PD OCT PY 2002 VL 59 SU S BP S106 EP S110 DI 10.1006/jmsc.2002.1269 PG 5 WC Fisheries; Marine & Freshwater Biology; Oceanography SC Fisheries; Marine & Freshwater Biology; Oceanography GA 615KC UT WOS:000179243500017 ER PT J AU Steimle, F Foster, K Kropp, R Conlin, B AF Steimle, F Foster, K Kropp, R Conlin, B TI Benthic macrofauna productivity enhancement by an artificial reef in Delaware Bay, USA SO ICES JOURNAL OF MARINE SCIENCE LA English DT Article; Proceedings Paper CT 7th International Conference on Artificial Reefs and related Aquatic Habitats CY OCT 07-11, 1999 CL SAN REMO, ITALY SP ICES, Italian Soc Marine Biol, European Artificial Reef Res Network, Sanremo Congressi Turismo, Univ Geona, Phillips Petr, European Commiss, US Natl Marine Fisheries Serv DE caloric conversions; epifauna; estuarine artificial reef; interannual variability; Mytilus edulis; taxon-specific P : B ID NEW-YORK-BIGHT; MYTILUS-EDULIS; MUSSEL BED; COMMUNITY; HABITAT; METABOLISM; MORTALITY; ESTUARY AB To understand the potential enhancement value of a habitat-loss mitigation reef in Delaware Bay, especially as a source of food for fishery resources, the secondary productivity of the reef epifauna and nearby sand infauna was estimated and compared. The mean production of natural sand infauna was estimated at between 215 and 249 kcal m(2) yr(-1), while that of the epifauna on the reef surfaces was between 3990 and 9555 kcal m(2) yr(-1). With the 36 m(2) footprint of a reef unit as a basis for comparison, the 407 m(2) of reef unit surface covering that footprint produced 1.62-3.89 X 10(6) kcal yr(-1) of epifauna compared with 7.74-8.96 X 10(3) kcal yr(-1) per footprint area for the adjacent sand infauna. There was, however, substantial annual variability in the productivity of the epifauna, based on the recruitment success of Mytilus edulis. Published by Elsevier Science Ltd on behalf of the International Council for the Exploration of the Sea. C1 Natl Marine Fisheries Serv, Sandy Hook Lab, Highlands, NJ 07732 USA. Battelle Ocean Sci, Duxbury, MA 02332 USA. US Dept Army, Corps Engineers, Philadelphia, PA 19107 USA. RP Steimle, F (reprint author), Natl Marine Fisheries Serv, Sandy Hook Lab, Highlands, NJ 07732 USA. NR 38 TC 5 Z9 5 U1 2 U2 7 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1054-3139 J9 ICES J MAR SCI JI ICES J. Mar. Sci. PD OCT PY 2002 VL 59 SU S BP S100 EP S105 DI 10.1006/jmsc.2002.1268 PG 6 WC Fisheries; Marine & Freshwater Biology; Oceanography SC Fisheries; Marine & Freshwater Biology; Oceanography GA 615KC UT WOS:000179243500016 ER PT J AU Jaster, JF AF Jaster, JF TI Digitized mapping: The key to achieving a common command and control picture SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB One of the main goals in transforming the Army is the process of moving away from the use of paper maps and grease pencils into more embedded and computer-oriented forms of command and control. There are currently many weapons platforms trying to achieve this function; however, each platform is developing their own solution to meet individual needs. The Army as a whole needs to standardize on a single path forward to ensure that all systems can communicate across the digitized battlefield, allow for each platform to have a "common picture," and promote software reuse across the Army. Once this "common picture" is achieved, our armed forces will have the information needed to continue our domination of the battlefield. C1 USA, TADREC, AMSTA, TR,RMS264, Warren, MI 48397 USA. RP Jaster, JF (reprint author), USA, TADREC, AMSTA, TR,RMS264, Warren, MI 48397 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD OCT PY 2002 VL 17 IS 10 BP 7 EP 12 DI 10.1109/MAES.2002.1044510 PG 6 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA 609TK UT WOS:000178920500004 ER PT J AU Tkach, Y Shkuratov, SI Talantsev, EF Dickens, JC Kristiansen, M Altgilbers, LL Tracy, PT AF Tkach, Y Shkuratov, SI Talantsev, EF Dickens, JC Kristiansen, M Altgilbers, LL Tracy, PT TI Theoretical treatment of explosive-driven ferroelectric generators SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE ferroelectric materials; pulse generation; shock waves AB As a part of the-New World Vistas Program, a series of ultra-compact explosive-driven ferroelectric generators (EDFEGs) has been designed, constructed, and tested by Texas Tech University providing well-documented EDFEG output parameters that were used to benchmark,a theoretical model of the EDFEG developed at the Institute of Electromagnetic Research. A description of the model for the EDFEG is presented along with a brief description of the EDFEG, the experimental setup, and test procedures that were used. A comparison of the experimental and calculated results shows them to be in good agreement. C1 Inst Electromagnet Res, Kharkov, Ukraine. Texas Tech Univ, Dept Elect & Comp Engn, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. USA, Space & Missile Def Command, Adv Technol Directorate, Huntsville, AL 35807 USA. Tracy Phys Sci Res, Madison, AL 35758 USA. RP Tkach, Y (reprint author), Inst Electromagnet Res, Kharkov, Ukraine. OI Talantsev, Evgeny/0000-0001-8970-7982 NR 6 TC 15 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2002 VL 30 IS 5 BP 1665 EP 1673 DI 10.1109/TPS.2002.806618 PN 1 PG 9 WC Physics, Fluids & Plasmas SC Physics GA 644XK UT WOS:000180945900010 ER PT J AU Krompholz, H Hatfield, LL Kristiansen, M Hemmert, D Short, B Mankowski, J Brown, MDJ Altgilbers, LL AF Krompholz, H Hatfield, LL Kristiansen, M Hemmert, D Short, B Mankowski, J Brown, MDJ Altgilbers, LL TI Gas breakdown in the subnanosecond regime with voltages below 15 kV SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE microwave breakdown; point-plane discharge; subnanosecond gas breakdown AB Gaseous breakdown in the subnanosecond regime is of interest for fast pulsed power switching, short pulse electromagnetics, and for plasma limiters to protect electronic devices from high power microwave radiation. Previous investigations of subnanosecond breakdown were mainly limited to high-pressure gases or liquids, with voltages in excess of 100 kV. In this paper, we investigate sulnanosecond breakdown at applied voltages below 7.5 kV in point-plane geometries in argon, with a needle radius <0.5 mum. The coaxial setup allows current and voltage measurements with temporal resolutions down to 80 ps. Voltages of 7.5 kV (which are doubled at the open gap before breakdown) produce breakdowns with a delay of about 1 ns. With negative pulses applied to the tip and the same amplitude, breakdown is always observed during the rising part of the pulse, with breakdown delay times below 800 ps, at pressures between 10(2) and 10(4) Pa. At lower pressure, a longer delay time (8 ns at 6 Pa) is observed. We expect the breakdown mechanism to be dominated by electron field emission, but still influenced by gaseous amplification. C1 Texas Tech Univ, Dept Elect Engn, Pulsed Power Lab, Lubbock, TX 79409 USA. Texas Tech Univ, Dept Phys, Pulsed Power Lab, Lubbock, TX 79409 USA. Accurate Automat Corp, Chattanooga, TN 37421 USA. USA, Space & Missile Def Command, Huntsville, AL 35810 USA. RP Krompholz, H (reprint author), Texas Tech Univ, Dept Elect Engn, Pulsed Power Lab, Lubbock, TX 79409 USA. NR 9 TC 9 Z9 12 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2002 VL 30 IS 5 BP 1916 EP 1921 DI 10.1109/TPS.2002.805388 PN 1 PG 6 WC Physics, Fluids & Plasmas SC Physics GA 644XK UT WOS:000180945900046 ER PT J AU O'Daniel, JL Krauthammer, T Koudela, KL Strait, LH AF O'Daniel, JL Krauthammer, T Koudela, KL Strait, LH TI An UNDEX response validation methodology SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 7th International Symposium on Structural Failure and Plasticity (IMPLAST 2000) CY OCT 04-06, 2000 CL MELBOURNE, AUSTRALIA AB The assessment of the response of naval vessels to underwater shock creates a need for tools that can analyze and design such systems to withstand underwater explosions (UNDEX). This paper describes a preliminary attempt to develop a methodology for the assessment of structural systems to UNDEX effects. A methodology is proposed by which the response of a simplified structural component to UNDEX can be validated through the use of precision impact testing and numerical simulations. An iterative process was used where an UNDEX response, determined through previous results, preliminary UNDEX simulations, and impact simulations, provided the parameters necessary for a precision impact test that generates an equivalent response. Precision impact tests were performed, and the results correlated with the impact simulated data. The results from an UNDEX test were compared with the predictions from the validated numerical code. The structural component in both the tests and simulations was simplified to a flat rectangular panel. The numerical simulations were solved explicitly, and included either the impact loading environment -a hybrid impactor with an initial velocity-or the UNDEX loading environment-a plane shock wave applied to the surface of the target structure. Since close-in and early time UNDEX-related phenomena, such as gas bubble effects, are localized and very complicated, they were ignored in this preliminary phase of the study. Although the proposed methodology could require multiple iterations, the limited scope of this study only included one set of precision-impact tests on each type of material, one UNDEX test against an aluminum panel, and two UNDEX tests against composite panels. Once the methodology using precision shock testing and numerical simulations to validate the UNDEX response had been developed, it was used to develop a "design-for-shock" procedure. Published by Elsevier Science Ltd. C1 USA, Ctr Res & Dev, Struct Mech Branch, Vicksburg, MS 39180 USA. Penn State Univ, University Pk, PA 16802 USA. RP O'Daniel, JL (reprint author), USA, Ctr Res & Dev, Struct Mech Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 9 TC 4 Z9 5 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD OCT PY 2002 VL 27 IS 9 BP 919 EP 937 AR PII S0734-743X(02)00014-3 DI 10.1016/S0734-743X(02)00014-3 PG 19 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 588PC UT WOS:000177709000004 ER PT J AU Cole, MW Joshi, PC Ervin, M Wood, M Pfeffer, RL AF Cole, MW Joshi, PC Ervin, M Wood, M Pfeffer, RL TI Evaluation of Ta2O5 as a buffer layer film for integration of microwave tunable Ba1-xSrxTiO3 based thin films with silicon substrates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; PULSED-LASER DEPOSITION; ELECTRICAL-PROPERTIES; TANTALUM OXIDE; DEVICE APPLICATIONS; MICROSTRUCTURE; DIELECTRICS; INTERFACE; SI AB Successful integration of Ba1-xSrxTiO3 (BST) based thin films with affordable Si substrates has a potential significant commercial impact as the demand for high-frequency tunable devices intensifies. This work evaluates the material properties of postdeposition annealed Ta2O5 thin films fabricated via the metalorganic solution technique for use as a passive buffer layer between BST and Si. The microstructure, surface morphology, and interfacial properties of the Ta2O5 film deposited on n(+)-Si and PtSi substrates was evaluated via field-emission scanning electron microscopy, Rutherford backscattering spectrometry, Auger electron spectroscopy, and atomic force microscopy. The presence of a transition interaction zone between the Ta2O5 film and Si substrate was detected after annealing at temperatures >600 degreesC. The width of the interaction zone increased with increasing annealing temperature reaching a maximum of 29 nm at 750 degreesC. The width of the interaction zone was also found to be dependent on the Ta2O5 film microstructure. The Ta2O5 film was typified by a smooth; fine grain, crack/pinhole free surface morphology. The presence of the interfacial layer had no appreciable effect on the microstructure of the film or surface morphology. The narrowness of the interaction zone with respect to the overall film thickness combined with the fact that the interfacial layer did not seriously deteriorate the dielectric properties of the Ta2O5 film suggests Ta2O5 to be a favorable candidate buffer layer enabling the integration of BST with Si substrates. (C) 2002 American Institute of Physics. C1 USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA. RP Cole, MW (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 33 TC 35 Z9 35 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2002 VL 92 IS 7 BP 3967 EP 3973 DI 10.1063/1.1505999 PG 7 WC Physics, Applied SC Physics GA 595BU UT WOS:000178087600082 ER PT J AU Powell, SK Goldsman, N McGarrity, JM Bernstein, J Scozzie, CJ Lelis, A AF Powell, SK Goldsman, N McGarrity, JM Bernstein, J Scozzie, CJ Lelis, A TI Physics-based numerical modeling and characterization of 6H-silicon-carbide metal-oxide-semiconductor field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRON-TRANSPORT; DEVICE SIMULATION; MONTE-CARLO; SILICON; INVERSION; EQUATIONS; VELOCITY; MOSFETS; 4H; SCATTERING AB A detailed analysis of silicon-carbide (SiC) metal-oxide-semiconductor field-effect-transistor (MOSFET) physics is performed. Measurements of current-voltage characteristics are taken. A device simulator is developed based on the drift-diffusion equations. The model accounts for incomplete ionization. Comprehensive mobility and interface state models are developed for SiC MOSFETs. The mobility model accounts explicitly for bulk transport, as well as for interface states, surface phonons and surface roughness. Agreement between simulated and measured terminal characteristics is obtained. The results provide values for interface state occupation as a function of energy and position along the surface. Results giving values for surface mobility as a function of position along the channel indicate that interface states have an especially strong effect on SiC operation. Our investigation indicates that substantial reduction of interface states can give rise to a fivefold increase in transconductance. (C) 2002 American Institute of Physics. C1 Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Powell, SK (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. NR 30 TC 42 Z9 47 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2002 VL 92 IS 7 BP 4053 EP 4061 DI 10.1063/1.1499523 PG 9 WC Physics, Applied SC Physics GA 595BU UT WOS:000178087600097 ER PT J AU Healy, WL Casey, DJ Iorio, R Appleby, D AF Healy, WL Casey, DJ Iorio, R Appleby, D TI Evaluation of the Porous-Coated Anatomic hip at 12 years SO JOURNAL OF ARTHROPLASTY LA English DT Article DE total hip arthroplasty (THA); cementless THA; osteoarthritis hip; 10-year result ID ACETABULAR COMPONENT; ARTHROPLASTY AB A total of 55 consecutive cementless total hip arthroplasties were done for osteoarthritis by 1 surgeon, who was not a designer of the implant, using I surgical technique and Porous-Coated Anatomic (Howmedica, Rutherford, NJ) hip implants. Of hips, 53 were prospectively evaluated, and 39 were followed for an average of 12.3 years (range, 10-16 years). Eight patients (8 hips) died, and 6 of 53 hips (11.3%) required revision for aseptic loosening at an average of 6.5 years. Five of 53 (9.4%) acetabular components were revised at an average of 7.9 years. Four of 53 (7.6%) femoral components were revised at an average of 5.1 years. Survivorship of these total hip arthroplasties was 98 +/- 3.9 at 5 years, 88.9 +/- 9.2 at 10 years, and 86.7 +/- 9.9 at 13 years with revision as the endpoint. C1 Lahey Clin Fdn, Med Ctr, Dept Orthopaed Surg, Burlington, MA 01805 USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Healy, WL (reprint author), Lahey Clin Fdn, Med Ctr, Dept Orthopaed Surg, 41 Mall Rd, Burlington, MA 01805 USA. NR 32 TC 13 Z9 14 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 0883-5403 J9 J ARTHROPLASTY JI J. Arthroplast. PD OCT PY 2002 VL 17 IS 7 BP 856 EP 863 DI 10.1054/arth.2002.34822 PG 8 WC Orthopedics SC Orthopedics GA 601RT UT WOS:000178462200007 PM 12375243 ER PT J AU Bernet, VJ Anderson, J Vaishnav, Y Solomon, B Adair, CF Saji, M Burman, KD Burch, HB Ringel, MD AF Bernet, VJ Anderson, J Vaishnav, Y Solomon, B Adair, CF Saji, M Burman, KD Burch, HB Ringel, MD TI Determination of galectin-3 messenger ribonucleic acid overexpression in papillary thyroid cancer by quantitative reverse transcription-polymerase chain reaction SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID FINE-NEEDLE ASPIRATION; TELOMERASE ACTIVITY; PREOPERATIVE DIAGNOSIS; BINDING PROTEIN; GENE-EXPRESSION; CELL-ADHESION; CARCINOMA; THYROGLOBULIN; LECTINS; TUMORS AB Galectin-3, a lectin-family protein that appears to be involved in malignant transformation, has been reported to be an accurate immunohistochemical marker for thyroid cancer. However, immunohistochemistry is a subjective method that can be difficult to apply to cytologic specimens. Therefore, we sought to develop an objective and quantitative assay to measure galectin-3 mRNA in thyroid tissue to enhance potential clinical use of galectin-3 in the molecular analysis of thyroid nodules. In this study, total RNA from 37 snap-frozen thyroid tissue specimens was isolated from eight papillary and nine follicular thyroid cancers, six follicular adenomas, seven adenomatoid nodules, and seven normal thyroid lobes from patients undergoing thyroidectomy. Normalized levels of galectin-3 mRNA, expressed as picograms per nanogram GAPDH mRNA, were higher in papillary carcinomas (3327 pg/ng) and follicular adenomas (1314 pg/ng) than in thyroid normal tissue (426 pg/ng; P = 0.0012 and 0.032, respectively). Galectin-3 mRNA levels were also higher in papillary cancers than in adenomatoid nodules (P = 0.0012). However, galectin-3 mRNA levels were not statistically greater in follicular carcinomas than either normal tissue or follicular adenomas (P = 0.068 and 0.12, respectively). In summary, in comparison to galectin-3 immunohistochemistry, quantitative measurement of galectin-3 mRNA appears useful in the identification of papillary thyroid cancers (PTCs) but does not appear to be useful in distinguishing follicular carcinomas from follicular adenomas. C1 Walter Reed Army Med Ctr, Serv Endocrinol, Endocrinol Diabet & Metab Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Washington Hosp Ctr, MedStar Res Inst, Endocrinol Sect, Washington, DC 20010 USA. RP Bernet, VJ (reprint author), Walter Reed Army Med Ctr, Serv Endocrinol, Endocrinol Diabet & Metab Serv, 7D,6900 Georgia Ave NW, Washington, DC 20307 USA. EM VICTOR.BERNET@NA.AMEDD.ARMY.MIL RI Saji, Motoyasu/E-4007-2011 NR 37 TC 38 Z9 41 U1 0 U2 1 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD OCT PY 2002 VL 87 IS 10 BP 4792 EP 4796 DI 10.1210/jc.2002-020390 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 604YZ UT WOS:000178649800062 PM 12364475 ER PT J AU Chandra, N Chen, XL Rajendran, AM AF Chandra, N Chen, XL Rajendran, AM TI The effect of material heterogeneity on the shock response of layered systems in plate impact tests SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE high velocity impact response; layered heterogeneous materials; scattering; rise characteristics; plate impact ID COMPOSITES; ARMOR AB In the study of shock wave propagation in solids, scattering, dispersion, and attenuation play a critical role in determining the thermomechanical response of the media. These phenomena can be attributed to a number of nonlinearities arising from the wave characteristics, loading conditions, material heterogeneity (measured at various spatial scales ranging from nanometers to a few millimeters). The nonlinear effects in general can be ascribed to impedance (and geometric) mismatch present at various length scales as often encountered in composite material systems, apart from material nonlinearities arising from inelastic effects, void nucleation and growth, cracking, and delamination. However, in nearly brittle material systems, elastic effects dominate and is the only effect considered here. Uniaxial strain experiments on the S-2 glass/polymer composite system display markedly different behavior than that observed in monolithic metallic systems [6] and this motivated the present work. Stress profiles measured at various locations along the direction of wave propagation in the plate impact experiments showed that the shock wave rise time increased with propagation in addition to the reduction of peak stress. In this work, we specifically address the issue of shock wave rise time in a simplified multi-layered system. A careful analysis of wave propagation in heterogeneous medium is performed by considering the elastic/acoustic properties of individual lamina in a layered system. An analytical model has been developed to describe the scattering process (reflection/transmission) at various layer interfaces of multilayer composite system. FEM results are then used to compare with the analytical predictions. These results show that the rise time can be a consequence of multiple internal reflections and transmissions occurring at the heterogeneous interfaces, it is further shown that the rise time depends on the magnitude of impedance mismatch and the number of layers. C1 Florida State Univ, Dept Mech Engn, Tallahassee, FL 32310 USA. Engn Sci Directorate Res, Army Res Off, Res Triangle Pk, NC 27709 USA. RP Chandra, N (reprint author), Florida State Univ, Dept Mech Engn, Tallahassee, FL 32310 USA. RI Rajendran, Arunachalam/A-1615-2010 NR 11 TC 4 Z9 4 U1 0 U2 7 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD OCT PY 2002 VL 24 IS 4 BP 232 EP 238 PG 7 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 610QM UT WOS:000178972000003 ER PT J AU Conner, SJ AF Conner, SJ TI Evaluation and treatment of the patient with allergic rhinitis SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID AQUEOUS NASAL SPRAY; QUALITY-OF-LIFE; PLACEBO-CONTROLLED TRIAL; PRACTICE PARAMETERS; FEXOFENADINE HCL; CAT ALLERGY; SKIN-TESTS; EFFICACY; LORATADINE; MANAGEMENT C1 Gen Leonard Wood Army Community Hosp, Dept Family Practice, Ft Leonard Wood, MO USA. RP Conner, SJ (reprint author), Eisenhower Army Med Ctr, Dept Family Practice, Ft Gordon, GA 30905 USA. NR 45 TC 5 Z9 5 U1 0 U2 0 PU DOWDEN PUBLISHING CORP PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD OCT PY 2002 VL 51 IS 10 BP 883 EP + PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 604HD UT WOS:000178610400018 PM 12401162 ER PT J AU Salerno, SM O'Malley, PG Pangaro, LN Wheeler, GA Moores, LK Jackson, JL AF Salerno, SM O'Malley, PG Pangaro, LN Wheeler, GA Moores, LK Jackson, JL TI Faculty development seminars based on the one-minute preceptor improve feedback in the ambulatory setting SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE feedback; ambulatory; teaching; faculty development ID TEACHING BEHAVIORS; MEDICAL-EDUCATION; STRATEGIES; PERCEPTIONS; EFFICIENT; OUTCOMES AB OBJECTIVE: While several models of medical student instruction in the ambulatory setting exist, few have been formally studied. We wished to assess the impact of a faculty development workshop based on the One-Minute Preceptor model on the amount and quality of feedback in the outpatient setting. DESIGN: Ambulatory teaching behaviors were studied during consecutive outpatient precepting sessions before and after 3 faculty development workshops. Student-teacher interactions were assessed using audiotapes of teaching encounters coded through qualitative techniques, and surveys of teacher, learner, and patient satisfaction. SETTING: Ambulatory internal medicine clinic in a tertiary care medical center. PATIENTS/PARTICIPANTS: Nine board-certified internist faculty preceptors and 44 third-year medical students. INTERVENTIONS: Three 90-minute faculty development seminars based on the One-Minute Preceptor teaching model. MEASUREMENTS AND MAIN RESULTS: Ninety-four encounters with 18,577 utterances were recorded, half before and half after the seminars. After the workshops, the proportion of utterances that contained feedback increased from 17% to 22% (P = .09) and was more likely to be specific (9% vs 15%; P = .02). After the workshops, teachers reported that the learning encounters were more successful (P = .03) and that they were better at letting the students reach their own Conclusions (P = .001), at evaluating the learners (P = .03), and at creating plans for post-encounter learning (P = .02). The workshops had no effect on the duration of the student-teacher encounter or on student or patient satisfaction with the encounters. CONCLUSIONS: Brief, interactive, faculty development workshops based on the One-Minute Preceptor model of clinical teaching resulted in modest improvements in the quality of feedback delivered in the ambulatory setting. C1 Tripler Army Med Ctr, Dept Med, MCHK DM, Honolulu, HI 96859 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Salerno, SM (reprint author), Tripler Army Med Ctr, Dept Med, MCHK DM, Honolulu, HI 96859 USA. NR 29 TC 53 Z9 57 U1 1 U2 2 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD OCT PY 2002 VL 17 IS 10 BP 779 EP 787 DI 10.1046/j.1525-1497.2002.11233.x PG 9 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 605KF UT WOS:000178676500006 PM 12390554 ER PT J AU Foley, PM Buesing, AW AF Foley, PM Buesing, AW TI Discussion of "Microscale loose-bed hydraulic models" by Stephen T. Maynord SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Editorial Material C1 USA, Corps Engn, St Paul, MN 55101 USA. RP Foley, PM (reprint author), USA, Corps Engn, St Paul, MN 55101 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 2002 VL 128 IS 10 BP 952 EP 952 DI 10.1061/(ASCE)0733-9429(2002)128:10(952) PG 1 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 598UV UT WOS:000178295600009 ER PT J AU Maynord, ST AF Maynord, ST TI Closure to "Microscale loose-bed hydraulic models" by Stephen T. Maynord SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Editorial Material C1 Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39181 USA. RP Maynord, ST (reprint author), Coastal & Hydraul Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39181 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 2002 VL 128 IS 10 BP 952 EP 952 DI 10.1061/(ASCE)0733-9429(2002)128:10(952.2) PG 1 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 598UV UT WOS:000178295600010 ER PT J AU Winstral, A Elder, K Davis, RE AF Winstral, A Elder, K Davis, RE TI Spatial snow modeling of wind-redistributed snow using terrain-based parameters SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID BLOWING SNOW; MOUNTAIN BASIN; ALPINE SITE; HYDROLOGY; RADIATION; TRANSPORT; PATTERNS; PRAIRIE; COVER AB Wind is widely recognized as one of the dominant controls of snow accumulation and distribution in exposed alpine regions. Complex and highly variable wind fields in rugged terrain lead to similarly complex snow distribution fields with areas of no snow adjacent to areas of deep accumulation. Unfortunately, these complexities have limited inclusion of wind redistribution effects in spatial snow distribution models. In this study the difficulties associated with physically exhaustive wind field modeling are avoided and terrain-based parameters are developed to characterize wind effects. One parameter, (Sx) over bar, was based on maximum upwind slopes relative to seasonally averaged winds to characterize the wind scalar at each pixel location in an alpine basin. A second parameter, (Sb) over bar measured upwind breaks in slope from a given location and was combined with an upwind application of (Sx) over bar to create a drift delineator parameter, D(0), which was used to delineate sites of intense redeposition on lee slopes. Based on 504 snow depth samples from a May 1999 survey of the upper Green Lakes Valley, Colorado, the correlation of the developed parameters to the observed snow distribution and the effect of their inclusion in a spatial snow distribution model were quantified. The parameter (Sx) over bar was found to be a significant predictor, accounting for more of the variance in the observed snow depth than could be explained by elevation, solar radiation, or slope. Samples located in D(0)-delineated drift zones were shown to have significantly greater depths than samples located in nondrift zones. A regression tree model of snow distribution based on a predictor variable set of (Sx) over bar, D(0), elevation, solar radiation, and slope explained 8%-23% more variance in the observed snow distribution, and performed noticeably better in unsampled areas of the basin, compared to a regression tree model based on only the latter three predictors. C1 ARS, NW Watershed Res Ctr, USDA, Boise, ID 83712 USA. US Forest Serv, Rocky Mt Res Stn, USDA, Ft Collins, CO USA. USA, Cold Reg Res & Engn Lab, Corps Engineers, Hanover, NH 03755 USA. RP Winstral, A (reprint author), ARS, NW Watershed Res Ctr, USDA, 800 Pk Blvd,Suite 105, Boise, ID 83712 USA. EM awinstra@nwrc.ars.usda.gov NR 52 TC 134 Z9 136 U1 3 U2 28 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD OCT PY 2002 VL 3 IS 5 BP 524 EP 538 DI 10.1175/1525-7541(2002)003<0524:SSMOWR>2.0.CO;2 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 606QU UT WOS:000178745300002 ER PT J AU Gourley, IS Kurtis, JD Kamoun, M Amon, JJ Duffy, PE AF Gourley, IS Kurtis, JD Kamoun, M Amon, JJ Duffy, PE TI Profound bias in interferon-gamma and interleukin-6 allele frequencies in Western Kenya, where severe malarial anemia is common in children SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NECROSIS-FACTOR-ALPHA; TNF GENE POLYMORPHISM; PLASMODIUM-FALCIPARUM; PROMOTER POLYMORPHISM; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; TRANSFERRIN UPTAKE; SCARRING TRACHOMA; CEREBRAL MALARIA; IRON-METABOLISM AB The intensity of malaria transmission is related to the pattern of malarial disease observed in different regions, but populations may also differ in their underlying predispositions to severe malarial anemia or cerebral malaria. In western Kenya, where severe malarial anemia is much more common than cerebral malaria, the distributions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, transforming growth factor (TGF)-beta, IL-6, and interferon (IFN)-gamma alleles were examined in a cohort of young men. The cohort displayed a marked bias toward genotypes associated with low expression of IFN-gamma and IL-6, cytokines that, at high levels, have been implicated in malarial anemia and poor malaria outcomes. By contrast, the frequency of the TNF-alpha -238A allele, which has been associated with severe malarial anemia, was found to be similar to the frequency previously reported in comparison populations in Africa and elsewhere. IFN-gamma and IL-6 genotypes may play roles in the development of severe malaria and could contribute to the relative frequency of severe malarial anemia or cerebral malaria in exposed populations. C1 Seattle Biomed Res Inst, Seattle, WA 98109 USA. Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, 4 Nickerson St,Ste 200, Seattle, WA 98109 USA. FU NIAID NIH HHS [AI43680, R01 AI48654] NR 42 TC 17 Z9 19 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2002 VL 186 IS 7 BP 1007 EP 1012 DI 10.1086/342947 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 593KU UT WOS:000177991100016 PM 12232842 ER PT J AU Wereszczak, AA Breder, K Ferber, MK Kirkland, TP Payzant, EA Rawn, CJ Krug, E Larocco, CL Pietras, RA Karakus, M AF Wereszczak, AA Breder, K Ferber, MK Kirkland, TP Payzant, EA Rawn, CJ Krug, E Larocco, CL Pietras, RA Karakus, M TI Dimensional changes and creep of silica core ceramics used in investment casting of superalloys SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID CRYSTALLIZATION; CRISTOBALITE AB Dimensional changes and creep deformation of a silica/zircon (74%/24%, respectively) and a high silica (93% silica and 3% zircon) ceramic were characterized and compared. All specimens were tested with a thermal profile that consisted of a 300degreesC/h heating rate to 1475 or 1525degreesC, followed by a one-hour isothermal hold (where each specimen was compressively crept under a static stress of 2.07, 4.14, or 6.21 MPa). The specimens were cooled at a rate of 900degreesC/h under stress. Dimensional changes were interpreted from apparent thermal expansion behavior during heating as well as before-and-after dimensional measurements. The silica/zircon ceramic generally exhibited less total contraction than the high silica ceramic for a specific test condition even though it crept faster at all stresses and temperatures during the one-hour isothermal/isostress segment. This indicates that the total contraction for both was dominated by reinitiated sintering and subsequent cristobalite formation that occurred during the heating segment. Minimum creep rate during the one-hour isothermal/isostress segment was examined as a function of stress and temperature for both ceramics using a power-law creep model. Creep-rate stress exponents (n) and activation energies (Q) were equivalent (within 95% confidence) for both ceramics showing that their different contents of zircon (3 vs. 24%) did not affect them. Lastly, n approximate to 1.3-1.4 and Q approximate to 170 kJ/mol indicate that diffusion-assisted crystallization of cristobalite, combined with power-law sintering owing to the high concentration of porosity (28-30%) was likely the rate-limiting mechanism in the creep deformation for both ceramics. (C) 2002 Kluwer Academic Publishers. C1 Oak Ridge Natl Lab, High Temp Mat Lab, Oak Ridge, TN 37831 USA. Certech Inc, Carpenter Engineered Molded Ceram Prod, Wood Ridge, NJ 07075 USA. Univ Missouri, Dept Ceram Engn, Rolla, MO 65409 USA. RP Wereszczak, AA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Payzant, Edward/B-5449-2009; Wereszczak, Andrew/I-7310-2016 OI Payzant, Edward/0000-0002-3447-2060; Wereszczak, Andrew/0000-0002-8344-092X NR 20 TC 22 Z9 30 U1 2 U2 15 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD OCT 1 PY 2002 VL 37 IS 19 BP 4235 EP 4245 DI 10.1023/A:1020060508311 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 590KN UT WOS:000177822200023 ER PT J AU Bowden, CM Chen, G Diao, ZJ Klappenecker, A AF Bowden, CM Chen, G Diao, ZJ Klappenecker, A TI The universality of the quantum Fourier transform in forming the basis of quantum computing algorithms SO JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS LA English DT Article AB The quantum Fourier transform (QFT) is a powerful tool in quantum computing. The main ingredients of QFT are formed by the Walsh-Hadamard transform H and phase shifts P(.), both of which are 2 x 2 unitary matrices as operators on the two-dimensional 1-qubit space. In this paper, we show that H and P(.) suffice to generate the unitary group U(2) and, consequently, through controlled-U operations and their concatenations, the entire unitary group U(2(n)) on n qubits; can be generated. Since any quantum computing algorithm in an n-qubit quantum computer is based on operations by matrices in U(2(n)), in this sense we have the universality of the QFT. (C) 2002 Elsevier Science (USA). All rights reserved. C1 Texas A&M Univ, Dept Math, College Stn, TX 77843 USA. USA, Missile Command, Ctr Res Dev & Engn, Redstone Arsenal, AL 35898 USA. Texas A&M Univ, Dept Comp Sci, College Stn, TX 77843 USA. RP Chen, G (reprint author), Texas A&M Univ, Dept Math, College Stn, TX 77843 USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-247X J9 J MATH ANAL APPL JI J. Math. Anal. Appl. PD OCT 1 PY 2002 VL 274 IS 1 BP 69 EP 80 AR PII S0022-247X(02)00227-5 DI 10.1016/S0022-247X(02)00227-5 PG 12 WC Mathematics, Applied; Mathematics SC Mathematics GA 615DU UT WOS:000179231200005 ER PT J AU Welkos, S Friedlander, A Weeks, S Little, S Mendelson, I AF Welkos, S Friedlander, A Weeks, S Little, S Mendelson, I TI In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID BACILLUS-ANTHRACIS; INHALATIONAL ANTHRAX; TOXIN COMPONENTS; LETHAL TOXIN; IMMUNITY; VIRULENCE; CORRELATE; SUBTILIS; STRAIN; MODEL AB Antibodies (Abs) to the protective antigen (PA) component of the anthrax toxins have anti-spore as well as anti-toxin activities. Anti-PA antisera and purified anti-PA Abs enhance the phagocytosis by murine-derived macrophages (MQs) of spores of the Ames and Sterne strains and retard the germination of extracellular spores in vitro. The fate after phagocytosis of untreated and anti-PA-treated spores was further studied in culture medium that supported phagocytosis without stimulating spore germination (Dulbecco's minimal essential medium with horse serum 10%). The spores germinated within cells of primary peritoneal murine MQs (C3H/NeH) and MQs of the RAW264.7 MQ-like cell line; germination was associated with a rapid decline in spore viability. Exposure of MQs to inhibitors of phago-endosomal acidification (bafilomycin A and chloroquine) reduced the efficiency of MQ killing and allowed outgrowth and replication of the organisms. Treatment of spores with anti-PA Abs stimulated their phagocytosis and was associated with enhanced MQ killing of the spores. The enhanced killing of spores correlated with the greater extent of germination of anti-PA-treated spores after phagocytosis. A PA null mutant of the Ames strain exhibited none of the effects associated with anti-PA Ab treatment of the parental strain. Thus, the anti-PA Ab-specific immunity induced by vaccines has anti-spore activities and its role in impeding the early stages of infection with Bacillus anthracis needs to be assessed. C1 USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Headquarters, Ft Detrick, MD 21702 USA. RP Welkos, S (reprint author), USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. NR 29 TC 104 Z9 108 U1 2 U2 4 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD OCT PY 2002 VL 51 IS 10 BP 821 EP 831 PG 11 WC Microbiology SC Microbiology GA 608YN UT WOS:000178875900004 PM 12435060 ER PT J AU Rogers, CJ AF Rogers, CJ TI Clausewitz, genius and the rules (Military theorist Carl von Clausewitz and his theory of war) SO JOURNAL OF MILITARY HISTORY LA English DT Article AB It is commonly believed that the great military theorist Carl von Clausewitz maintained that "genius rises above the rules." This note demonstrates to the contrary that, in his view, a good theory of war could and should describe rules of universal explanatory (though not prescriptive) value, while the statement "genius rises above the rules" actually denied the utility of military theory. Geniuses violate only the incorrect or oversimplified rules of bad theory; they succeed because they understand the true rules better than "blinkered" theorists who try to explain the phenomena of war without taking account of moral forces. C1 US Mil Acad, W Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 12 TC 3 Z9 3 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2002 VL 66 IS 4 BP 1167 EP 1176 DI 10.2307/3093268 PG 10 WC History SC History GA 597QC UT WOS:000178231400008 ER PT J AU Rogers, CJ AF Rogers, CJ TI Problematics of military power: Government, discipline and the subject of violence SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2002 VL 66 IS 4 BP 1191 EP 1193 DI 10.2307/3093274 PG 3 WC History SC History GA 597QC UT WOS:000178231400016 ER PT J AU Rafuse, ES AF Rafuse, ES TI Extraordinary circumstances: The Seven Days Battle SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Rafuse, ES (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2002 VL 66 IS 4 BP 1209 EP 1210 DI 10.2307/3093290 PG 2 WC History SC History GA 597QC UT WOS:000178231400032 ER PT J AU Willbanks, JH AF Willbanks, JH TI Historical dictionary of the Vietnam War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Willbanks, JH (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2002 VL 66 IS 4 BP 1254 EP 1255 DI 10.2307/3093327 PG 2 WC History SC History GA 597QC UT WOS:000178231400070 ER PT J AU Bauman, RT AF Bauman, RT TI Russo-Chechen conflict, 1800-2000: A deadly SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bauman, RT (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2002 VL 66 IS 4 BP 1264 EP 1265 DI 10.2307/3093335 PG 2 WC History SC History GA 597QC UT WOS:000178231400078 ER PT J AU Clark, S Rene, A Theurer, WM Marshall, M AF Clark, S Rene, A Theurer, WM Marshall, M TI Association of body mass index and health status in firefighters SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID FITNESS; OBESITY AB This study evaluates the usefulness of body mass index (BMI) as a preventive screening tool for general health and duty fitness status among firefighters. Two major BMI categorization methods were used: (1) "standard " [low (<27), medium (&GE;27 <30), high (>30)]; and (2) WHO [(normal (<25), overweight (&GE;25 <30), obese (greater than or equal to30 <39), morbidly obese (&GE;39)]. Using the "standard" categorization, nearly 60% of individuals had medium or high BMI's; using the World Health Organization categorization, 80.7% of individuals were found to be overweight, obese, or morbidly obese. Statistically significant, inverse correlation between BMI and each of the following parameters was noted: systolic and diastolic blood pressure, VO2max, METS, and total cholesterol. Inconsistent or statistically insignificant correlation triglycerides, FVC % predicted, and FEV1 second % predicted. Findings were similar to previous studies of such correlates. BMI continues to prove useful as a screening tool and may be useful in identifying individual firefighters for health and fitness intervention measures. C1 Univ N Texas, Hlth Sci Ctr, Dept Environm & Occupat Hlth, Sch Publ Hlth, Bedford, TX USA. Univ N Texas, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Bedford, TX USA. Univ N Texas, Hlth Sci Ctr, Dept Social & Behav Sci, Sch Publ Hlth, Bedford, TX USA. USA, Womack Army Med Ctr, Ft Bragg, NC USA. RP Clark, S (reprint author), 2708 Maple Brook Court, Bedford, TX 76021 USA. NR 27 TC 41 Z9 41 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD OCT PY 2002 VL 44 IS 10 BP 940 EP 946 DI 10.1097/01.jom.0000034345.94005.02 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603MD UT WOS:000178562700012 PM 12391773 ER PT J AU Baur, DA Helman, JI AF Baur, DA Helman, JI TI The posteriorly based platysma flap in oral and facial reconstruction: A case series SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID MYOCUTANEOUS FLAP AB Purpose: The purpose of this study was to assess the reliability and use of the posteriorly based platysma flap for oral and facial reconstruction. Patients and Methods: This case series consists of 7 patients who were reconstructed with a posteriorly based platysma flap for various tumor resection defects of the oral and facial region. The flaps were monitored for complications, including skin loss and ischemia in the postoperative period. Results: Three of the patients (43%) in this study had no complications. Three patients (43%) had some skin sloughing, but the underlying muscle remained viable and mucosalized normally. One patient (14%) had 40% flap loss of the distal end, possibly due to vascular compromise that occurred during a concomitant neck dissection. Conclusion: The posteriorly based platysma flap is a reliable reconstruction option for defects in the facial and oral region. If skin sloughing occurs, it is usually inconsequential for intraoral reconstruction as the underlying muscle remains viable and undergoes epithelialization. (C) 2002 American Association of Oral and Maxillofacial Surgeons. C1 USA, Washington, DC USA. Univ Michigan, Med Ctr, Ann Arbor, MI USA. RP Helman, JI (reprint author), Univ Michigan Hosp, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA. NR 12 TC 10 Z9 14 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD OCT PY 2002 VL 60 IS 10 BP 1147 EP 1150 DI 10.1053/joms.2002.34989 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 600LN UT WOS:000178392000010 PM 12378489 ER PT J AU Young, SK Mauritz, KA AF Young, SK Mauritz, KA TI Nafion (R)/(organically modified silicate) nanocomposites via polymer in situ sol-gel reactions: Mechanical tensile properties SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE Nafion (R); sol-gel; organically modified silicate; mechanical properties; nanocomposites; ionomers; membranes; modulus ID ANGLE X-RAY AB A series of Nafion((R))/[organically modified silicate (ORMOSIL)] hybrid materials have been created by in situ sol-gel copolymerizations of tetraethylorthosilicate and semiorganic silicon alkoxide monomers. The trends in the mechanical tensile properties of these hybrid materials were largely rationalized in terms of the entrapment of the long sulfonic acid side chains in silicate or ORMOSIL structures. There is a significant increase in the mechanical strength relative to that of unfilled Nafion((R)) except in one case. Young's modulus is enhanced relative to that of unfilled acid form Nafion((R)) in a number of cases, although the degree of ductility is reduced relative to that of unfilled Nafion((R)). The filler fractions are beneath a critical value that would reflect percolation of a glassy, direct load-bearing silicate phase. (C) 2002 Wiley Periodicals, Inc. C1 Univ So Mississippi, Dept Polymer Sci, Hattiesburg, MS 39406 USA. RP Mauritz, KA (reprint author), USA, Res Lab, AMSRL WM MA Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. NR 9 TC 25 Z9 26 U1 0 U2 6 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD OCT 1 PY 2002 VL 40 IS 19 BP 2237 EP 2247 DI 10.1002/polb.10282 PG 11 WC Polymer Science SC Polymer Science GA 593JX UT WOS:000177989000010 ER PT J AU Baumeister, M Starke, J AF Baumeister, M Starke, J TI Improving student confidence through metacognative learning SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article ID SELF-EFFICACY C1 US Mil Acad, W Point, NY 10996 USA. RP Baumeister, M (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 6 TC 1 Z9 1 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD OCT PY 2002 VL 128 IS 4 BP 145 EP 148 DI 10.1061/(ASCE)1052-3928(2002)128:4(145) PG 4 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 598UT UT WOS:000178295400001 ER PT J AU Salgado, CJ Smith, A Kim, S Higgins, J Behnam, A Herrera, HR Serletti, JM AF Salgado, CJ Smith, A Kim, S Higgins, J Behnam, A Herrera, HR Serletti, JM TI Effects of late loss of arterial inflow on free flap survival SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY LA English DT Article DE free flaps; neovascularization; irradiation; flap arterial inflow loss ID NEOVASCULARIZATION AB Greater than 80 percent of free flap thromboses have been shown to occur within the first three postoperative days, warranting immediate re-exploration and restoration of adequate vessel patency. The infrequency of thromboses beyond this period is reflected in the lack of reported cases in the literature and the absence of accepted guidelines for the treatment of such delayed complications. A single study reported free flap survival in vessel thromboses only when encountered after postoperative day (POD) 7 in a pig model. Since 1990, over 800 free tissue transfers have been done at the University of Rochester. A total of ten cases of late (defined as after POD 7) arterial inflow loss were identified and examined. A retrospective chart review recorded patient demographics, site of tissue defect, free tissue transferred, major co-morbidities, preoperative XRT, timing of arterial inflow loss, nature of inflow loss, and flap survival. The mean POD of arterial inflow loss was 53 days grange: 8 to 166). The mean age of patients was 58 years. No major co-morbidities correlated with late arterial inflow loss. Loss of inflow occurred as anastomotic rupture (5), occlusion of recipient bypass graft in lower extremity cases (3), primary donor arterial thrombosis (1), and pedicle avulsion during re-exploration for seroma (1). Five flaps survived, one sustained partial necrosis, and four were completely lost. Of the five surviving flaps, three were inset into healthy recipient sites. One was utilized on a dysvascular lower extremity, and another was used in an irradiated neck defect. Of the four failed flaps, all were placed in recipient beds compromised by radiation, ischemia, or scarring. Two exemplary case reports are presented. The timing of late loss of arterial inflow does not appear to be the primary determinant of free tissue survival. The condition and quality of the recipient site plays a large role in survival of these flaps. Ischemic, irradiated, and scarred beds are inadequate in providing late flap neovascularization, compared to healthy recipient sites. When encountering late loss of arterial inflow in flaps placed on such compromised beds, the microsurgeon should not anticipate survival based on surrounding vessel ingrowth. More aggressive salvage attempts may be warranted. C1 Darnall US Army Hosp, Plast Surg Sect, Ft Hood, TX USA. RP Serletti, JM (reprint author), Univ Rochester, Div Plast Surg, 601 Elmwood Ave,Box 661, Rochester, NY 14642 USA. NR 10 TC 46 Z9 47 U1 0 U2 1 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0743-684X J9 J RECONSTR MICROSURG JI J. Reconstr. Microsurg. PD OCT PY 2002 VL 18 IS 7 BP 579 EP 583 DI 10.1055/s-2002-35095 PG 5 WC Surgery SC Surgery GA 603EW UT WOS:000178546700003 PM 12404130 ER PT J AU Smith, PA Sheely, MV Kluchinsky, TA AF Smith, PA Sheely, MV Kluchinsky, TA TI Solid phase microextraction with analysis by gas chromatography to determine short term hydrogen cyanide concentrations in a field setting SO JOURNAL OF SEPARATION SCIENCE LA English DT Article DE hydrogen cyanide; solid phase microextraction; CS riot control agent; ceiling exposure standard; gas chromatography ID SPME AB Occupational air concentration ceiling standards should not be exceeded during any Part of a working exposure. Air sampling with pumps, and filters or sorbent tubes may be coupled to methods such as gas chromatography for definitive identification of occupational air contaminants. With such methods, 15-minute sample durations are common for ceiling standard comparisons (to trap sufficient analyte for detection) giving a 15-minute time-weighted average, and not an instantaneous concentration. We used 2-minute duration solid phase microextraction (SPME) field sampling, followed later by gas chromatography with a nitrogen-phosphorous detector (GC/NPD) to detect, identify, and quantify airborne hydrogen cyanide (HCN) concentrations encountered in a field setting. The presence of HCN was confirmed in the atmosphere sampled by SPME field sampling followed by gas chromatography with mass spectrometric detection. The HCN-contaminated atmosphere was from two CS riot control canisters actuated in an enclosed building. With four simultaneous SPME field samples and GC/NPD analysis, the coefficient of variation associated with the HCN peak areas for the samples was 17%, and the HCN concentrations measured ranged from about 12 to 19 ppm. Acetonitrile and acrylonitrile were also detected as volatile nitrogen-containing air contaminants dispersed along with the CS, although their concentrations were not determined. C1 Uniformed Serv Univ Hlth Sci, PMB Dept, Bethesda, MD 20814 USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Smith, PA (reprint author), Uniformed Serv Univ Hlth Sci, PMB Dept, A-1044,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RI Smith, Philip/A-6835-2009 OI Smith, Philip/0000-0003-3787-9111 NR 14 TC 15 Z9 15 U1 1 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1615-9314 J9 J SEP SCI JI J. Sep. Sci. PD OCT PY 2002 VL 25 IS 14 BP 917 EP 921 DI 10.1002/1615-9314(20021001)25:14<917::AID-JSSC917>3.0.CO;2-F PG 5 WC Chemistry, Analytical SC Chemistry GA 614TU UT WOS:000179207500009 ER PT J AU Eloseily, KH Ayyub, BM Patev, R AF Eloseily, KH Ayyub, BM Patev, R TI Reliability assessment of pile groups in sands SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article DE pile foundation; pile groups; reliability; limit states; limit analysis; failure modes AB A probability-based reliability assessment methodology for single flexible piles and pile groups under stochastic lateral loads is developed. The methodology was based on state-of-the-art techniques for the analysis of single piles and pile groups as well as reliability assessment methods. Critical strength and serviceability modes of failure for flexible piles in sandy soil under lateral loads were defined. The reliability of a pile-group system was assessed by accounting for system redundancy with the occurrence of partial failures of the system components. Reliability indices and failure probabilities were used as relative measures for the performance of piles. A case study was presented to illustrate the proposed methodology. C1 Bechtel Corp, Facil Staff Design, Frederick, MD 21703 USA. Univ Maryland, Dept Civil Engn, Ctr Technol & Syst Management, College Pk, MD 20742 USA. USA, Corps Engineers, Waterways Expt Stn, Informat Technol Lab, Vicksburg, MS 39183 USA. RP Eloseily, KH (reprint author), Bechtel Corp, Facil Staff Design, 5275 Westview Dr, Frederick, MD 21703 USA. NR 12 TC 6 Z9 6 U1 2 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD OCT PY 2002 VL 128 IS 10 BP 1346 EP 1353 DI 10.1061/(ASCE)0733-9445(2002)128:10(1346) PG 8 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 598UN UT WOS:000178295000013 ER PT J AU Shoop, S Kestler, M Stark, J Ryerson, C Affleck, R AF Shoop, S Kestler, M Stark, J Ryerson, C Affleck, R TI Rapid stabilization of thawing soils: field experience and application SO JOURNAL OF TERRAMECHANICS LA English DT Article DE bearing capacity; trafficability; frost; thaw; soil; stablization AB Thawing soils can severely restrict vehicle travel on unpaved surfaces. However, a variety of materials and construction techniques can be used to stabilize thawing soils to reduce immobilization problems. The US Engineer Research and Development Center's Army Cold Regions Research and Engineering Laboratory (CRREL) and the Wisconsin National Guard evaluated several stabilization techniques in a field demonstration project during spring thaw at Fort McCoy, Wisconsin, in 1995. Additional tests on chemical stabilizing techniques were conducted at CRREL's Frost Effects Research Facility. The results of these test programs were reduced to a decision matrix for stabilizing thawing ground, and used during the deployment of US troops in Bosnia during January and February of 1996. The soil frost and moisture conditions expected during this time frame were predicted using MIDFROCAL (MIDwest FROst CALculator). This paper is an overview of the stabilization techniques evaluated and their recommended application based on the expected soil frost conditions and traffic requirements. Although the experiments were performed with military vehicles in mind, the techniques are suitable for many civilian applications such as forestry, construction, mining, and oil exploration. Published by Elsevier Ltd on behalf of ISTVS. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Shoop, S (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 14 TC 3 Z9 3 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD OCT PY 2002 VL 39 IS 4 BP 181 EP 194 DI 10.1016/S0022-4898(02)00019-8 PG 14 WC Engineering, Environmental SC Engineering GA 711DE UT WOS:000184723700001 ER PT J AU Ravikrishna, R Valsaraj, KT Thibodeaux, LJ Price, CB Brannon, JM Yost, S AF Ravikrishna, R Valsaraj, KT Thibodeaux, LJ Price, CB Brannon, JM Yost, S TI Volatilization of contaminants from suspended sediment in a water column during dredging SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID POLLUTANTS; TURBULENCE; INTERFACE AB Remedial dredging of contaminated bed sediments in rivers and lakes results in the suspension of sediment solids in the water column, which can potentially be a source for evaporation of hydrophobic organic compounds (HOCs) associated with the sediment solids. Laboratory experiments were conducted in an oscillating grid chamber to simulate the suspension of contaminated sediments and flux to air from the surface of the water column. A contaminated field sediment from Indiana Harbor Canal (IHC) and a laboratory-inoculated University Lake (UL) sediment, Baton Rouge, LA, were used in the experiments, where water and solids concentration and particle size distribution were measured in addition to contaminant fluxes to air. A transient model that takes into account contaminant desorption from sediment to water and evaporation from the water column was used to simulate water and sediment concentrations and air fluxes from the solids suspension. In experiments with both sediments, the total suspended solids (TSS) concentration and the average particle diameter of the suspended solids decreased with time. As expected, the evaporative losses were higher for compounds with higher vapor pressure and lower hydrophobicity. For the laboratory-inoculated sediment (UL), the water concentrations and air fluxes were high initially and decreased steadily implying that contaminant release to the water column from the suspended solids was rapid, followed by evaporative decay. For the field sediments (IHC), the fluxes and water concentrations increased initially and subsequently decreased steadily. This implied that the initial desorption to water was slow and that perhaps the presence of oil and grease and aging influenced the contaminant release. Comparison of the model and experimental data suggested that a realistic determination of the TSS concentration that can be input into the model was the most critical parameter for predicting air emission rates. C1 Louisiana State Univ, Gordon A & Mary Cain Dept Chem Engn, Baton Rouge, LA 70803 USA. USA, Environm Lab, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. Dyn Tel Corp, Vicksburg, MS 39180 USA. RP Valsaraj, KT (reprint author), Louisiana State Univ, Gordon A & Mary Cain Dept Chem Engn, Baton Rouge, LA 70803 USA. NR 21 TC 3 Z9 4 U1 0 U2 9 PU AIR & WASTE MANAGEMENT ASSOC PI PITTSBURGH PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA SN 1047-3289 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD OCT PY 2002 VL 52 IS 10 BP 1214 EP 1229 PG 16 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 604DL UT WOS:000178600600009 PM 12418732 ER PT J AU Gould, SA Moore, EE Hoyt, DB Ness, PM Norris, EJ Carson, JL Hides, GA Freeman, IHG DeWoskin, R Moss, GS AF Gould, SA Moore, EE Hoyt, DB Ness, PM Norris, EJ Carson, JL Hides, GA Freeman, IHG DeWoskin, R Moss, GS TI The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article; Proceedings Paper CT Meeting of the Clinical-Congress-of-the-American-College-of-Surgeons CY OCT, 2001 CL CHICAGO, ILLINOIS SP Amer Coll Surg ID BLOOD SUBSTITUTE; AORTIC-SURGERY; ACUTE TRAUMA; TRANSFUSION; ANEMIA; OXYGEN; TRIAL; MORTALITY; MORBIDITY; TRANSPORT AB BACKGROUND: Human polymerized hemoglobin (PolyHeme, Northfield Laboratories, Evanston, 11) is a universally compatible, immediately available, disease-free, oxygen-carrying resuscitative fluid being developed as a red cell substitute for use in urgent blood loss. PolyHeme should be particularly useful when red cells may be temporarily unavailable. This article assesses survival at life-threatening RBC hemoglobin concentration ([Hb]) in massively bleeding patients who do not receive red cells. STUDY DESIGN: There were 171 patients who received rapid infusion of I to 20 units (1,000 g, 10 Q of PolyHeme in lieu of red cells as initial oxygen-carrying replacement in trauma and urgent surgery. The protocol simulated the unavailability of red cells, and the progressive fall in RBC [Hb] in bleeding patients was quantified. Thirty-day mortality was compared with a historical control group of 300 surgical patients who refused red cells on religious grounds. RESULTS: A total of 171 patients received rapid infusion of 1 to 2 units (n = 45), 3 to 4 units (n = 45), 5 to 9 units (n = 47), or 10 to 20 units (n = 34) of PolyHeme. Forty patients had a nadir RBC [Hb] less than or equal to 3 g/dL (mean, 1.5 +/- 0.7 g/dL). But total [Hb] was adequately maintained (mean, 6.8 +/- 1.2 g/dL) because of plasma [Hb] added by PolyHeme. The 30-day mortality was 25.0% (10/40 patients) compared with 64.5% (20/31 patients) in historical control patients at these RBC [Hb] levels. CONCLUSIONS: PolyHeme increases survival at life-threatening RBC [Hb] by maintaining total [Hb] in the absence of red cell transfusion. PolyHeme should be useful in the early treatment of urgent blood loss and resolve the dilemma of unavailability of red cells. (C) 2002 by the American College of Surgeons. C1 Northfield Labs Inc, Evanston, IL USA. Univ Illinois, Coll Med, Dept Surg, Chicago, IL 60680 USA. Denver Hlth Med Ctr, Dept Surg, Denver, CO USA. Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA. Univ Calif San Diego, Med Ctr, Dept Surg, San Diego, CA 92103 USA. Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA. Johns Hopkins Univ Hosp, Dept Pathol & Med, Baltimore, MD 21287 USA. Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA. Johns Hopkins Univ Hosp, Dept Anesthesiol, Baltimore, MD 21287 USA. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Div Gen Internal Med, New Brunswick, NJ 08903 USA. Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Gould, SA (reprint author), 1560 Sherman Ave,Suite 1000, Evanston, IL 60201 USA. NR 37 TC 126 Z9 130 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2002 VL 195 IS 4 BP 445 EP 452 AR PII S1072-7515(02)01335-2 DI 10.1016/S1072-7515(02)01335-2 PG 8 WC Surgery SC Surgery GA 600GC UT WOS:000178381400001 PM 12375748 ER PT J AU Carlson, NE Roach, RB AF Carlson, NE Roach, RB TI Platelet-rich plasma - Clinical applications in dentistry SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article ID TISSUE REGENERATIVE THERAPY; GROWTH-FACTOR; FIBRIN GLUE; BONE; GRAFTS; REPAIR; GEL AB Background. Platelet-rich plasma, or PRP, has become a valuable adjunct in wound healing in dentistry. Postsurgically, blood clots initiate the healing and regeneration of hard and soft tissues. Clinicians and scientists are investigating the use of PRP in dentistry as a way to enhance the body's natural wound-healing mechanisms. Types of Articles Reviewed. The authors reviewed scientific articles that discuss the basic knowledge of wound healing mechanisms and that directly studied the growth factors shown to be concentrated in PRP. They also reviewed articles written by clinicians and researchers in dentistry fields, including oral and maxillofacial surgery and periodontics to determine applications of PRP in the field of dentistry. Results. All of the reviewed articles expressed promise in PRP use and in the growth factors expressed by the platelets concentrated in PRP-namely platelet-derived growth factor, or PDGF, and transforming growth factor-beta, or TGF-beta- as an adjunct to postsurgical wound healing. Both PDGF and TGF-beta have been shown in vivo to accelerate wound healing through different mechanisms. The development of an autologous PRP has been shown to be relatively easy, to be effective as a surgical adjunct, to retain high levels of the desired growth factors after preparation and to be clinically effective in accelerating postsurgical healing in both periodontal and oral surgery applications. Clinical Implications. PRP has proven to be effective at improving surgical results in a variety of procedures in the field of oral and maxillofacial surgery. PRP also shows promise in periodontal regenerative therapy and should continue to be studied by scientists and clinicians alike. C1 USA, Dent Corps, Madigan Army Med Ctr, Ft Lewis, WA USA. RP Roach, RB (reprint author), 1715 Palmer View, San Antonio, TX 78258 USA. NR 13 TC 85 Z9 96 U1 3 U2 9 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD OCT PY 2002 VL 133 IS 10 BP 1383 EP 1386 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 605JN UT WOS:000178674900020 PM 12403541 ER PT J AU Conner, DA Edwards, BD Decker, WA Marcolini, MA Klein, PD AF Conner, DA Edwards, BD Decker, WA Marcolini, MA Klein, PD TI NASA/Army/Bell XV-15 tiltrotor low noise terminal area operations flight research program SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Three phases of XV-15 acoustic flight tests have been conducted over a five-year period by a NASA/Army/Bell Helicopter team to evaluate the noise reduction potential for tiltrotor aircraft during terminal area operations. Lower hemispherical noise characteristics for a wide range of steady-state terminal area type operating conditions were measured during the phase 1 test and indicated that the takeoff and level flight conditions were not significant contributors to the total noise of tiltrotor operations. Phase 1 results were used to design low noise approach profiles that were tested during the phase 2 and phase 3 tests, which used large area microphone arrays to directly measure the ground noise footprints. Approach profile designs emphasized noise reduction while attempting to maintain handling qualities sufficient for tiltrotor commercial passenger ride comfort and flight safety under Instrument Flight Rules (IFR) conditions. This paper will discuss the weather, aircraft, tracking, guidance, and acoustic instrumentation systems, as well as the approach profile design philosophy, and the overall test program philosophy. Acoustic results are presented documenting the variation in tiltrotor noise due to changes in operating condition, indicating the potential for significant noise reduction using the unique tiltrotor capability of nacelle tilt. C1 USA, Aviat & Missile Command, Langley Res Ctr, Directorate AMRDEC, Hampton, VA 23681 USA. Bell Helicopter Textron Inc, Acoust, Ft Worth, TX 76101 USA. USA, NASA, Ames Res Ctr,Rotorcraft Div, Flight Control & Cockpit Integrat Branch, Moffett Field, CA 94035 USA. NASA, Langley Res Ctr, Adv Measurement & Diag Branch, Hampton, VA 23681 USA. Bell Helicopter Textron Inc, Adv Syst Dev, Ft Worth, TX 76101 USA. RP Conner, DA (reprint author), USA, Aviat & Missile Command, Langley Res Ctr, Directorate AMRDEC, Hampton, VA 23681 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2002 VL 47 IS 4 BP 219 EP 232 PG 14 WC Engineering, Aerospace SC Engineering GA 606AD UT WOS:000178708500001 ER PT J AU Lyle, KH Bark, LW Jackson, KE AF Lyle, KH Bark, LW Jackson, KE TI Evaluation of test/analysis correlation methods for crash applications SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 57th Annual Forum of the American-Helicopter-Society CY MAY 09-11, 2001 CL WASHINGTON, D.C. SP Amer Helicopter Soc AB A research project has been initiated to improve crash test and analysis correlation. The work described in this paper is focused on the test and simulation results for a fuselage section. Two drop tests of the section were conducted. The first test was designed to excite the linear structural response for comparison with finite element modal analysis results. The second test was designed to provide data for correlation with crash simulations. An MSC.Dytran model was developed to generate nonlinear transient dynamic results. Following minor modifications, the same model was executed in MSC.Nastran to generate modal analysis results. The results presented in this paper concentrate on evaluation of correlation methodologies for crash test data and finite element simulation results. C1 NASA, Langley Res Ctr, Hampton, VA 23665 USA. MSC Software, Santa Ana, CA USA. USA, Vehicle Technol Directorate, Hampton, VA USA. RP Lyle, KH (reprint author), NASA, Langley Res Ctr, Hampton, VA 23665 USA. NR 8 TC 3 Z9 3 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2002 VL 47 IS 4 BP 233 EP 242 PG 10 WC Engineering, Aerospace SC Engineering GA 606AD UT WOS:000178708500002 ER PT J AU Abbott, KC Bucci, JR Cruess, D Taylor, AJ Agodoa, LYC AF Abbott, KC Bucci, JR Cruess, D Taylor, AJ Agodoa, LYC TI Graft loss and acute coronary syndromes after renal transplantation in the United States SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID DIALYSIS PATIENTS; ARTERY DISEASE; HEART-DISEASE; RISK-FACTORS; RECIPIENTS; HOSPITALIZATIONS; PREVALENCE; SURVIVAL AB The impact of graft loss on acute coronary syndromes (ACS) after renal transplantation has not been studied in a national population. It was hypothesized that ACS might be more frequent after graft loss, as many of the benefits of a functioning allograft on metabolism and volume regulation would be lost. Data from the 2000 United States Renal Data System (USRDS) was used to conduct an historical cohort study of ACS in 14,237 patients who received renal transplants between April 1, 1995, and June 30, 1998, (followed until April 28, 2000) with valid information from CMS Form 2728, excluding patients with hospitalized ACS before renal transplant. Cox nonproportional regression models were used to calculate the time-dependent adjusted hazard ratio (AHR) of graft loss (censored for death) for time-to-first hospitalization for ACS (International Classification of Diseases 9th Modification Diagnosis Codes [ICD9] code 410.x or 411.x) occurring after transplant. The incidence of ACS was 12.1 per 1000 patient-years (PY) in patients after graft loss versus 6.5 per 1000 PY after transplantation (excluding patients with graft loss). As a time-dependent variable, graft loss had an AHR of 2.54 (95% confidence interval, 1.09 to 5.96; P = 0.031 by Cox regression). Other risk factors associated with ACS included diabetes, older recipient, and male recipient. Allograft rejection was NS. Renal transplant recipients share some of the risk factors for ACS with the general population. In addition, graft loss was identified as a unique risk factor for ACS in this population. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. NIDDK, NIH, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 32 TC 40 Z9 40 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD OCT PY 2002 VL 13 IS 10 BP 2560 EP 2569 DI 10.1097/01.ASN.0000028800.84746.CB PG 10 WC Urology & Nephrology SC Urology & Nephrology GA 595HV UT WOS:000178103800021 PM 12239246 ER PT J AU Carmody, BJ Arora, S Wakefield, MC Weber, M Fox, CJ Sidawy, AN AF Carmody, BJ Arora, S Wakefield, MC Weber, M Fox, CJ Sidawy, AN TI Progesterone inhibits human infragenicular arterial smooth muscle cell proliferation induced by high glucose and insulin concentrations SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID GROWTH-FACTOR-I; ESTROGEN-RECEPTOR; POSTMENOPAUSAL ESTROGEN; DISEASE; RISK AB Introduction: Diabetes mellitus is a significant risk factor for atherosclerotic peripheral vascular disease. Hyperglycemia and hyperinsulinemia, as encountered in patients with type II diabetes, have been shown to stimulate vascular smooth muscle cell (VSMC) proliferation, a paramount feature in atherosclerosis. Female sex hormones, such as estrogen, have been suggested to inhibit VSMC proliferation. However, the role of progesterone, particularly in patients with diabetes mellitus, has not been examined. Therefore, we studied the effect of progesterone on VSMCs exposed to various concentrations of glucose and insulin. Methods. Human infragenicular VSMCs isolated from the tibial arteries of five male patients with diabetes undergoing lower extremity amputation were used. Immunocytochemical studies with confocal microscopy were performed for progesterone receptor identification in these VSMCs. Cells were grown to subconfluence, followed by exposure to deprived media with various glucose (100 and 200 mg/dL) and insulin (no insulin and 100 ng/mL) concentrations. Cells were then additionally exposed to physiologic progesterone (10 ng/mL, progesterone group) and compared with a no-progesterone group. Cell count and methyl-H-3-thymidine incorporation were used to determine cellular proliferation. Cell count with hemocytometry was performed on day 6. DNA synthesis as reflected through methyl-H-3-thymidine incorporation was measured at 24 hours. Results. Immunocytochemical studies with confocal microscopy showed cytosolic progesterone receptors. The no progesterone group showed a significant rise in cell count (P < .05) at all concentrations of glucose or insulin compared with the control group containing 100 mg/dL glucose concentration. The no-progesterone group also showed a significant rise in thymidine incorporation (P < .05) in the 100 mg/dL glucose-100 ng/mL insulin group and the 200 mg/dL glucose-100 ng/mL insulin group compared with the 100 mg/dL glucose group. In the cell count studies, progesterone significantly inhibited cellular proliferation in several settings. All cell groups cultured with insulin or an elevated glucose concentration showed a significant (P < .05) antiproliferative effect when exposed to progesterone. With thymidine incorporation, progesterone showed a similar antiproliferative effect in cells stimulated with glucose or insulin. Conclusion: Significant reductions in cell proliferation as determined with both cell count and thymidine incorporation suggest that progesterone is an inhibitor of VSMC proliferation induced by our in vitro models of hyperglycemia and hyperinsulinemia. Therefore, progesterone may have a protective role against the atherosclerotic changes associated with type II diabetes. C1 George Washington Univ, Med Ctr, Dept Surg,Vet Affairs Med Ctr, Walter Reed Army Med Ctr, Washington, DC 20037 USA. RP Sidawy, AN (reprint author), 50 Irving St NW, Washington, DC 20422 USA. NR 25 TC 9 Z9 9 U1 0 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD OCT PY 2002 VL 36 IS 4 BP 833 EP 838 DI 10.1067/mva.2002.127525 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 604JV UT WOS:000178617900029 PM 12368746 ER PT J AU Cao, XH Mello, SV Sui, GD Mabrouki, M Leblanc, RM AF Cao, XH Mello, SV Sui, GD Mabrouki, M Leblanc, RM TI Surface chemistry and spectroscopic and microscopic properties of organophosphorus hydrolase Langmuir and Langmuir-Blodgett films SO LANGMUIR LA English DT Article ID RECOMBINANT ESCHERICHIA-COLI; PSEUDOMONAS-DIMINUTA; NERVE AGENTS; CARBAMATE INSECTICIDES; ACETYLCHOLINE ESTERASE; BIOSENSOR; PESTICIDES; PHOSPHOTRIESTERASE; CHOLINESTERASE; HYDROLYSIS AB The composition of the subphase to obtain a stable organophosphorus hydrolase (OPH) monolayer was reexamined. The surface pressure-area (g-A) isotherms show that a subphase at pH 7.6 with 0.5 M KCl can lead to a limiting molecular area close to the X-ray crystal data. The stability of the OPH monolayer at the air-water interface was tested by two different methods: the compression-decompression cycle isotherms and kinetics measurements. There was no change in the limiting molecular area during the compression-decompression cycle isotherms and only a very small change over a period of 120 min at constant surface pressure of 20 mN m(-1) was observed, which are good indications for a stable OPH monolayer formation at the air-water interface. The surface potential-area isotherm was measured for OPH at the air-water interface, indicating the orientation of the polar moiety of the macromolecules during the compression. The UV-vis absorption spectra of the monolayer were recorded in situ at the air-water interface to investigate the organization of the OPH molecules. Topographies of OPH molecules at the air-water and the air-solid interfaces were studied by Brewster angle microscopy (BAM) and atomic force microscopy (AFM), respectively. The size of the molecules measured from the AFM image agrees with the limiting molecular area per molecule. C1 Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. RI MABROUKI, Mustapha/B-2421-2012 OI MABROUKI, Mustapha/0000-0001-8975-9803 NR 45 TC 16 Z9 17 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD OCT 1 PY 2002 VL 18 IS 20 BP 7616 EP 7622 DI 10.1021/la020326g PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 598WV UT WOS:000178300200054 ER PT J AU Burgess, EB AF Burgess, EB TI Odysseus in America: Combat trauma and the trials of homecoming. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 2002 VL 127 IS 16 BP 114 EP 114 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 754JQ UT WOS:000187313100135 ER PT J AU Russell, K Sodhi, RS AF Russell, K Sodhi, RS TI Instant screw axis point synthesis of the RRSS mechanism SO MECHANISM AND MACHINE THEORY LA English DT Article ID MOTION AB This paper presents a precision point synthesis of the RRSS motion generator, by specifying a set of successive points to the instantaneous screw axis. The method involves synthesizing RRSS mechanisms to achieve prescribed crank and coupler displacement angles by incorporating instant screw axis (ISA) points in the fixed axode point polynomial and calculating the R-R and S-S link parameters of this mechanism. The synthesis is facilitated by specific geometry of the RRSS mechanism, where the fixed axode is calculated as intersection of the R-R member plane and the S-S member axis. The RRSS fixed axode point polynomial was developed using the Cosine law approach introduced by Muller [Kansas State University Special Report No. 21, June 1962]. Complete expansion of the developed RRSS fixed axode point polynomial reveals that it is of order 56. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. USA, Ctr Res Dev & Engn, Close Combat Armaments Ctr, Picatinny Arsenal, NJ 07806 USA. RP Sodhi, RS (reprint author), New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. NR 11 TC 12 Z9 13 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0094-114X J9 MECH MACH THEORY JI Mech. Mach. Theory PD OCT PY 2002 VL 37 IS 10 BP 1117 EP 1126 AR PII S0094-114X(02)00047-2 DI 10.1016/S0094-114X(02)00047-2 PG 10 WC Engineering, Mechanical SC Engineering GA 607DE UT WOS:000178775500008 ER PT J AU Emanuel, SF Bedno, SA Holland, JC Earles, JE AF Emanuel, SF Bedno, SA Holland, JC Earles, JE TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. RP Emanuel, SF (reprint author), Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2002 VL 167 IS 10 BP III EP IV PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 653EB UT WOS:000181421300001 PM 12392241 ER PT J AU Calkins, MD Reese, K Costello, M Mu, T Bentley, TB AF Calkins, MD Reese, K Costello, M Mu, T Bentley, TB TI Evaluation of possible battlefield suction pumps for the far-forward setting SO MILITARY MEDICINE LA English DT Article ID OROPHARYNGEAL AB Medical personnel use suction pumps to clear a patient's airway of mucous, blood, and emesis. Because of size, weight, and durability, many commercially available suction pumps are not suited for battlefield application. The objective of this study was to identify a well-designed suction pump for use in the far forward environment. We report on the performance of seven candidate battlefield suction pumps, all of which are human-powered devices and intended to be carried by medics. Three commercially available pumps, one modified device, a syringe, and two new prototypes are evaluated and compared. We show that all of the devices are capable of generating suction pressure, but one pump stands out in terms of size, weight, and performance. C1 Walter Reed Army Inst Res, Dept Resuscitat Med, Washington, DC 20307 USA. Oregon State Univ, Dept Mech Engn, Corvallis, OR 97331 USA. RP Calkins, MD (reprint author), Walter Reed Army Inst Res, Dept Resuscitat Med, Washington, DC 20307 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2002 VL 167 IS 10 BP 803 EP 809 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 653EB UT WOS:000181421300004 PM 12392244 ER PT J AU Shry, EA Leding, CJ Rubal, BJ Eisenhauer, MD AF Shry, EA Leding, CJ Rubal, BJ Eisenhauer, MD TI The role of limited echocardiography and electrocardiography in screening physicals for amateur athletes SO MILITARY MEDICINE LA English DT Article ID SUDDEN CARDIAC DEATH; HYPERTROPHIC CARDIOMYOPATHY; YOUNG-ADULTS; CARDIOVASCULAR-DISEASE; HEART; POPULATION; CHILDREN AB Sudden cardiac death in seemingly healthy young people during exertion has led to preparticipation assessment of athletes. Typically, cardiac evaluation is limited to auscultation by a primary care provider. Screening electrocardiography is controversial. The value of limited echocardiography is unknown. High school athletes undergoing preparticipation evaluation for organized athletics completed a medical history questionnaire and were examined with standardized history and physical, 12-lead electrocardiogram, and a limited two-dimensional echocardiogram. The studies were interpreted by cardiologists. Of 95 subjects recruited, there were 55 females and 40 males. There were 10 abnormalities detected requiring further evaluation, two by electrocardiogram and eight by echocardiography. Only one abnormality was found with screening physical examination. Abnormalities occurred with similar frequency (13% vs. 9%) in those with and without cardiovascular symptoms. Screening echocardiography and electrocardiography are of benefit in identification of cardiac anomalies not appreciated on routine physical examinations. Further study of these screening modalities is warranted. C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Serv Cardiol, Brooks AFB, TX 78235 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. William Beaumont Army Med Ctr, Serv Cardiol, El Paso, TX 79920 USA. RP Shry, EA (reprint author), Brooke Army Med Ctr, Dept Med, Bldg 3600, Ft Sam Houston, TX 78234 USA. NR 20 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2002 VL 167 IS 10 BP 831 EP 834 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 653EB UT WOS:000181421300011 PM 12392250 ER PT J AU Nassiri, JD Daniel, JC Wilckens, J Land, BC AF Nassiri, JD Daniel, JC Wilckens, J Land, BC TI The implementation and use of the standardized assessment of concussion at the US Naval Academy SO MILITARY MEDICINE LA English DT Article ID SPORTS AB The Standardized Assessment of Concussion (SAC), a sideline mental status assessment tool, was used for the U.S. Naval Academy football team. Baseline SAC data were obtained for 298 subjects; the SAC was also used in immediate assessment and subsequent monitoring of 21 concussed players. Analysis of baseline data revealed no significant difference in SAC score based on position on team, position category (offense, defense, or special team), test form used, graduating class year, or history of prior concussion, nor was there any correlation on the basis of age. Among injured players, there was a significant drop in mean SAC total score from baseline to immediately following concussion. Surveys by athletic trainers and physicians who used the SAC indicated that, despite identifying potential limitations, they considered it to be easy and quick to administer and a useful tool in the assessment, monitoring, and management of concussed athletes at U.S. Naval Academy. C1 USN, Med Clin, Dept Mil Med, Annapolis, MD 21402 USA. USN, Med Clin, Dept Orthoped, Annapolis, MD 21402 USA. Womack Army Med Ctr, Dept Family Practice, Ft Bragg, NC 28310 USA. RP Daniel, JC (reprint author), Amer Embassy Jakarta, Unit 8132, NAMRU 2, FPO, AP 96520 USA. NR 9 TC 12 Z9 12 U1 1 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2002 VL 167 IS 10 BP 873 EP 876 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 653EB UT WOS:000181421300020 ER PT J AU Sun, M Ma, LF Xu, LD Li, J Zhang, W Petrovics, G Makarem, M Sesterhenn, I Zhang, M Blanchette-Mackie, EJ Moul, J Srivastava, S Zou, ZQ AF Sun, M Ma, LF Xu, LD Li, J Zhang, W Petrovics, G Makarem, M Sesterhenn, I Zhang, M Blanchette-Mackie, EJ Moul, J Srivastava, S Zou, ZQ TI A human novel gene DERPC located on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors SO MOLECULAR MEDICINE LA English DT Article ID E-CADHERIN EXPRESSION; COMPARATIVE GENOMIC HYBRIDIZATION; SIGNAL-TRANSDUCTION; SUPPRESSOR GENE; BREAST-CANCER; HETEROZYGOSITY; IDENTIFICATION; CHROMOSOME-8; PROTEINS; REGIONS AB Background: Deletion of chromosome 16q is frequently associated with diverse tumors. Numerous studies strongly suggest the presence of one or more tumor suppressor genes on chromosome 16q22 to 16qter including the widely studied cadherin gene family. However, the specific tumor suppressor genes residing in this region need better definition and characterization. Material and Methods: Standard molecular biology approaches have been used to clone and characterize the DERPC cDNA and its protein product on chromosome 16q22.1. Northern blotting was used to define the expression pattern in a multiple human tissue blots. DERPC expression was examined in multi-tumor array (Clontech, CA, USA) dot blot as well as in laser capture microdissection (LCM) derived prostate cancer (CaP) specimens by quantitative RT-PCR. Western blot analysis and a fluorescent microscopy were used to characterize the molecular size and the cellular location of green fluorescent protein (GFP)-tagged DERPC fusion proteins. A colony formation assay was conducted to determine the effects of DERPC expression on tumor cell growth. Results: A novel gene DERPC (Decreased Expression in Renal and Prostate Cancer) was identified and characterized. DERPC encoded a strong basic, proline- and glycine-rich nuclear protein. DERPC was ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. DERPC expression was reduced in renal (67%) and prostate tumors (33%). Expression of DERPC has inhibitory potential on CaP cell growth. Further, overexpression of DERPC in LNCaP cells caused alterations of nuclear morphology. Conclusion: This study suggests that decreased expression of DERPC may be implicated in tumorigenesis of renal and CaPs. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC USA. NIH, NIDDKD, Lab Cell Biochem & Biol, Sect Lipid Cell Biol, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Surg, Serv Urol, Washington, DC USA. RP Zou, ZQ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 40 TC 7 Z9 11 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4319 USA SN 1076-1551 J9 MOL MED JI Mol. Med. PD OCT PY 2002 VL 8 IS 10 BP 655 EP 663 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 621BV UT WOS:000179569400010 PM 12477976 ER PT J AU Liu, DR Hohil, ME Smith, SH AF Liu, DR Hohil, ME Smith, SH TI N-bit parity neural networks: new solutions based on linear programming SO NEUROCOMPUTING LA English DT Article; Proceedings Paper CT 8th European Symposium on Artificial Neural Networks (ESANN) CY APR 26-28, 2001 CL BRUGGE, BELGIUM DE N-bit parity problem; exclusive-OR problem; neural networks ID FEEDFORWARD NETS AB In this paper, the N-bit parity problem is solved with a neural network that allows direct connections between the input layer and the output layer. The activation function used in the hidden and output layer neurons is the threshold function. It is shown that this choice of activation function and network structure leads to several solutions for the 3-bit parity problem using linear programming. One of the solutions for the 3-bit parity problem is then generalized to obtain a solution for the N-bit parity problem using [N/2] hidden layer neurons. Compared to other existing solutions in the literature, the present solution is more systematic and simpler. Furthermore, the present solution can be simplified by using a single hidden layer neuron with a "staircase" type activation function instead of [N/2] hidden layer neurons. The present activation function is easier to implement in hardware than those in the literature for N-bit parity networks. We also review similarities and differences between the present results and those obtained in the literature. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. USA, TACOM, AMSTA, AR,FSF,RM, Picatinny Arsenal, NJ 07806 USA. Stevens Inst Technol, Dept Elect & Comp Engn, Hoboken, NJ 07030 USA. RP Liu, DR (reprint author), Univ Illinois, Dept Elect & Comp Engn, 851 S Morgan St, Chicago, IL 60607 USA. RI Liu, Derong/A-5304-2010 OI Liu, Derong/0000-0003-3715-4778 NR 11 TC 16 Z9 17 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-2312 J9 NEUROCOMPUTING JI Neurocomputing PD OCT PY 2002 VL 48 BP 477 EP 488 AR PII S0925-2312(01)00612-9 DI 10.1016/S0925-2312(01)00612-9 PG 12 WC Computer Science, Artificial Intelligence SC Computer Science GA 601TT UT WOS:000178464600030 ER PT J AU Convertino, VA AF Convertino, VA TI Planning strategies for development of effective exercise and nutrition countermeasures for long-duration space flight SO NUTRITION LA English DT Article DE space flight; microgravity; nutrition; exercise; countermeasures; physical working capacity; orthostatic tolerance; muscle; bone ID HIGH-IMPACT EXERCISE; ORTHOSTATIC INTOLERANCE; MAXIMAL EXERCISE; BED REST; SIMULATED MICROGRAVITY; INTENSE EXERCISE; PLASMA-VOLUME; SPACEFLIGHT; BONE; RESPONSES AB Exercise and nutrition represent primary countermeasures used during space flight to maintain or restore maximal aerobic capacity, musculoskeletal structure, and orthostatic function. However, no single exercise, dietary regimen, or combination of prescriptions has proven entirely effective in maintaining or restoring cardiovascular and musculoskeletal functions to preflight levels after prolonged space flight. As human space flight exposures increase in duration, identification, assessment, and development of various effective exercise- and nutrition-based protective procedures will become paramount. The application of adequate dietary intake in combination with effective exercise prescription will be based on identification of basic physiologic stimuli that maintain normal function in terrestrial gravity, and understanding how specific combinations of exercise characteristics (e.g., duration, frequency, intensity, and mode) can be combined with minimal nutritional requirements that mimic the stimuli normally produced by living in Earth's gravity environment. This can be accomplished only with greater emphasis of research on ground-based experiments targeted at understanding the interactions between caloric intake and expenditure during space flight. Future strategies for application of nutrition and exercise countermeasures for long-duration space missions must be directed to minimizing crew time and the impact on life-support resources. (C) Elsevier Science Inc. 2002. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 76 TC 22 Z9 24 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0899-9007 J9 NUTRITION JI Nutrition PD OCT PY 2002 VL 18 IS 10 BP 880 EP 888 AR PII S0899-9007(02)00939-5 DI 10.1016/S0899-9007(02)00939-5 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 599ZU UT WOS:000178366300016 PM 12361783 ER PT J AU Winter, WE Kucera, PR Rodgers, W McBroom, JW Olsen, C Maxwell, GL AF Winter, WE Kucera, PR Rodgers, W McBroom, JW Olsen, C Maxwell, GL TI Surgical staging in patients with ovarian tumors of low malignant potential SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID SEROUS BORDERLINE TUMORS; GYNECOLOGIC-ONCOLOGY-GROUP; PERITONEAL IMPLANTS; CARCINOMA; BEHAVIOR; SURGERY AB OBJECTIVE: To compare the outcomes of patients with ovarian tumors of low malignant potential who had complete surgical staging with those who were unstaged to determine whether the rate of recurrence or survival was affected by surgical staging. METHODS: A retrospective chart review was performed on 93 consecutive patients who had surgery for histologically confirmed tumors of low malignant potential between 1979 and 1997. Two cohorts of patients were identified: patients who had classic surgical staging (n = 48) versus those who were not staged (n = 45). Outcome data were recorded for patients and compared between the two groups. RESULTS: Early stage (I or H) disease was diagnosed in 31 of 48 patients who had surgical staging and 42 of 45 patients who were not staged (P =.001). In 17% of patients their stage was upgraded on the basis of surgical staging, as a result of retroperitoneal involvement in only 6% of those cases (three of 48 staged patients). During the study interval, the frozen section diagnosis of low malignant potential tumor of the ovary was changed to a final diagnosis of invasive cancer in eight other patients. There were three recurrences and two deaths in both the staged and unstaged low malignant potential groups. The average duration of follow-up was 6.5 +/- 4.2 years and was similar in the two groups. Overall 5-year survival was approximately 93% for all stages. CONCLUSION: Survival and recurrence rates were not significantly different between staged and unstaged patients who had surgery for low malignant potential tumors of the ovary. (C) 2002 by The American College of Obstetricians and Gynecologists. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. Oregon Hlth Sci Univ, Dept Obstet, Portland, OR 97201 USA. Oregon Hlth Sci Univ, Dept Gynecol, Portland, OR 97201 USA. Oregon Hlth Sci Univ, Dept Pathol, Portland, OR 97201 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Maxwell, GL (reprint author), 5217 Chevy Chase Pkwy, Washington, DC 20015 USA. NR 24 TC 71 Z9 75 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 2002 VL 100 IS 4 BP 671 EP 676 AR PII S0029-7844(02)02171-3 DI 10.1016/S0029-7844(02)02171-3 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 600JB UT WOS:000178385900010 PM 12383532 ER PT J AU Maxwell, GL Carlson, JW Ochoa, M Krivak, T Rose, GS Myers, ER AF Maxwell, GL Carlson, JW Ochoa, M Krivak, T Rose, GS Myers, ER TI Costs and effectiveness of alternative strategies for cervical cancer screening in military beneficiaries SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 33rd Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 02-07, 2002 CL MIAMI, FLORIDA SP Soc Gynecol Oncologists ID CONCURRENT CHEMOTHERAPY; PELVIC RADIATION; CISPLATIN; NEOPLASIA; WOMEN AB OBJECTIVE: To estimate the potential effects, on costs and outcomes, of changes in sensitivity and specificity associated with new screening methods for cervical cancer in the military. METHODS: A Markov model of the natural history of cervical cancer was created to simulate a cohort of 100,000 military beneficiaries aged 18-85. Probability estimates for various outcomes and the accuracy of screening tests were obtained from the literature. Cost estimates were obtained from military sources where available; otherwise, civilian costs were used. The outcomes and costs of conventional cytology, liquid-based cytology, and liquid-based cytology with human papillomavirus (HPV) triage were compared at 1-, 2-, and 3-year screening frequencies. RESULTS: Marginal reductions in the incidence of cervical cancer from increasing screening sensitivity are greater than reductions in cancer mortality at every screening interval. Incremental improvements in both cancer incidence and mortality are higher at less frequent screening intervals. Increases in the ratio of low- to high-grade lesions result from increasing the sensitivity of the screening test or shortening the screening interval. Both liquid-based cytology and liquid-based cytology with HPV testing are cost effective (less than $50,000 per life-year saved) when performed at 3-year screening intervals. However, neither strategy is cost-effective when performed more frequently than every 3 years. CONCLUSION: Use of a more sensitive cervical cancer screening test increases costs. However, a more sensitive test performed less frequently may be more effective and less expensive than conventional cytology done annually. In the military setting, this has significant implications for both expense reduction and readiness enhancement. (C) 2002 by The American College of Obstetricians and Gynecologists. C1 Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA. Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Myers, ER (reprint author), Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA. NR 26 TC 33 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 2002 VL 100 IS 4 BP 740 EP 748 AR PII S0029-7844(02)02196-6 DI 10.1016/S0029-7844(02)02195-6 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 600JB UT WOS:000178385900021 PM 12383543 ER PT J AU Bliese, PD Ployhart, RE AF Bliese, PD Ployhart, RE TI Growth modeling using random coefficient models: Model building, testing, and illustrations SO ORGANIZATIONAL RESEARCH METHODS LA English DT Article ID HIERARCHICAL LINEAR-MODELS; INTERINDIVIDUAL DIFFERENCES; INTRAINDIVIDUAL CHANGES; INDIVIDUAL CHANGE; PERFORMANCE; CRITERIA; TIME AB In this article, the authors illustrate how random coefficient modeling can be used to develop models for the analysis of longitudinal data. In contrast to previous discussions of random coefficient models, this article provides step-by-step guidance using a model comparison framework. By approaching the modeling this way, the authors are able to build off a regression foundation and progressively estimate and evaluate more complex models. In the model comparison framework, the article illustrates the value of using likelihood tests to contrast alternative models (rather than the typical reliance oil tests of significance involving individual parameters), and it provides code in the open-source language R to allow, readers to replicate the results. The article concludes with practical guidelines for estimating growth models. C1 Walter Reed Army Inst Res, Washington, DC 20307 USA. George Mason Univ, Fairfax, VA 22030 USA. RP Bliese, PD (reprint author), Walter Reed Army Inst Res, Washington, DC 20307 USA. RI Page, Andrew/G-5438-2012 OI Page, Andrew/0000-0003-3133-2844 NR 38 TC 220 Z9 222 U1 4 U2 41 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1094-4281 J9 ORGAN RES METHODS JI Organ. Res. Methods PD OCT PY 2002 VL 5 IS 4 BP 362 EP 387 DI 10.1177/109442802237116 PG 26 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 596HU UT WOS:000178159700003 ER PT J AU Grabenstein, JD AF Grabenstein, JD TI Response to Dr Halsey & AVEC: Analyze both forests and trees SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Letter C1 USA, Med Command, Anthrax Vaccine Immunizat Program Agcy, Falls Church, VA USA. RP Grabenstein, JD (reprint author), USA, Med Command, Anthrax Vaccine Immunizat Program Agcy, Falls Church, VA USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX PO19 1UD, ENGLAND SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD OCT-NOV PY 2002 VL 11 IS 7 BP 615 EP 616 DI 10.1002/pds.727 PG 2 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 615PQ UT WOS:000179255700011 PM 12462140 ER PT J AU Munavalli, S Rohrbaugh, DK Rossman, DI Durst, HD Dondoni, A AF Munavalli, S Rohrbaugh, DK Rossman, DI Durst, HD Dondoni, A TI Reactions of trifluoromethylsulfenyl chloride and trifluoromethylthiocopper with 2-(trimethylsilyl)thiazole SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE ring contraction; silylthiazole; trifluoromethylthiolation; trifluoromethylthiocopper ID TOXIC CYCLIC PEPTIDE; ORGANIC-SYNTHESIS; REAGENTS AB The treatment of 2-(trimethylsilyl)thiazole with trifluoromethylsulfenyl chloride furnishes the expected 2-(trifluoromethylthio)thiazole in satisfactory yields along with the ring contraction product of the azirine-type. However, the reaction of 2-bromothiazol with trifluoromethylthio-copper gives poor yields of the above compound. The mechanism of formation and the mass spectral characterization of the products are presented in this article. C1 Geocenters Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. Univ Ferrara, Dipartimento Chim, I-44100 Ferrara, Italy. RP Munavalli, S (reprint author), Geocenters Inc, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM sxmunava@sbccom.APGEA.army.mil NR 23 TC 7 Z9 7 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD OCT PY 2002 VL 177 IS 10 BP 2465 EP 2470 DI 10.1080/10426500290110595 PG 6 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 612KY UT WOS:000179075500026 ER PT J AU Munavalli, S Rossman, DI Rohrbaugh, DK Durst, HD AF Munavalli, S Rossman, DI Rohrbaugh, DK Durst, HD TI Photo-trifluoromethylthiolation of cyclopropyl phenyl propargyl alcohol SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE cyclopropyl ring cleavage; trifluoromethylthiyl and chlorine radical addition and substitution ID CLEAVAGE; REAGENTS; BROMINE AB Seven compounds are formed in various amounts when a solution of cyclopropopyl phenyl propargyl alcohol and trifluoromethylsulfenyl chloride in acetonitrile is exposed to UV light. The probable mechanism of formation and the mass spectral characterization of these compounds are described. C1 Geocenters Inc, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Munavalli, S (reprint author), Geocenters Inc, Aberdeen Proving Ground, MD 21010 USA. NR 33 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD OCT PY 2002 VL 177 IS 10 BP 2471 EP 2479 DI 10.1080/10426500290110612 PG 9 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 612KY UT WOS:000179075500027 ER PT J AU Picozzi, S West, BJ AF Picozzi, S West, BJ TI Fractional Langevin model of memory in financial markets SO PHYSICAL REVIEW E LA English DT Article ID PRICE FLUCTUATIONS; DYNAMICS; VOLATILITY; RELAXATION; CALCULUS AB The separation of the microscopic and macroscopic time scales is necessary for the validity of ordinary statistical physics and the dynamical description embodied in the Langevin equation. When the microscopic time scale diverges, the differential equations on the macroscopic level are no longer valid and must be replaced with fractional differential equations of motion; in particular, we obtain a fractional-differential stochastic equation of motion. After decades of statistical analysis of financial time series certain "stylized facts" have emerged, including the statistics of stock price fluctuations having "fat tails" and their linear correlations in time being exceedingly short lived. On the other hand, the magnitude of these fluctuations and other such measures of market volatility possess temporal correlations that decay as an inverse power law. One explanation of this long-term memory is that it is a consequence of the time-scale separation between "microscopic" and "macroscopic" economic variables. We propose a fractional Langevin equation as a dynamical model of the observed memory in financial time series. C1 Duke Univ, Dept Phys, Durham, NC 27706 USA. USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Picozzi, S (reprint author), Duke Univ, Dept Phys, Durham, NC 27706 USA. RI West, Bruce/E-3944-2017 NR 51 TC 49 Z9 49 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD OCT PY 2002 VL 66 IS 4 AR 046118 DI 10.1103/PhysRevE.66.046118 PN 2 PG 12 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 614EX UT WOS:000179176300029 PM 12443270 ER PT J AU Mauritz, KA Storey, RF Reuschle, DA Tan, NB AF Mauritz, KA Storey, RF Reuschle, DA Tan, NB TI Poly(styrene-b-isobutylene-b-styrene)block copolymer ionomers (BCPI) and BCPI/silicate nanocomposites. 2. Na+BCPI sol-gel polymerization templates SO POLYMER LA English DT Article DE block copolymer ionomer template; in situ sol-gel reactions; ionomer/silicate nanocomposite ID OXIDE> HYBRID MATERIALS; NA-23 NMR; MECHANICAL-PROPERTIES; POLYSTYRENE IONOMERS; PHYSICAL-PROPERTIES; ALKOXIDES AB Polystyrene (PS) blocks in poly(styrene-b-isobutylene-b-styrene) (PS-PIB-PS) block copolymers were partially sulfonated and the acid groups converted to Na+SO3- groups to create ionomers. Then, dimethylacetamide was used to selectively swell the ionic PS domains and the swollen films were exposed. to sol-gel reactive tetraethylorthosilicate solutions. (EtO)(4-x)Si(OH)(x) monomers then permeated films so that sol-gel reactions occurred within/around the ionic PS domains. Environmental scanning electron microscopy/energy dispersive X-ray spectroscopy investigations showed that silicate structures can be incorporated within the interior of the ionomer films. Differential scanning calorimetry studies indicated that there is no variance in the PIB block T-g with respect to ionomer formation, or with respect to silicate loading of the ionomer at low levels, which suggests that the silicate component does not reside in the PIB phase. Na-23 solid state NMR spectroscopy detected isolated Na+SO3- groups as well as aggregated SO3-Na+ ion pairs for 'as cast' and 'dry' non-silicate containing ionomer samples. In a hydrated sample, almost all Na+ ions were solvent-separated. AFM analysis showed that phase separation exists, but that the degree of order is significantly less than that for hybrids based on the corresponding benzyltrimethylammonium ionomer. This frustrated morphology was also seen in the results of small angle X-ray scattering experiments. Given the scale of organic/inorganic heterogeneity, these hybrids are properly classified as nanocomposites. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 Univ So Mississippi, Dept Polymer Sci, Hattiesburg, MS 39406 USA. Dow Chem Co USA, Freeport, TX 77541 USA. USA, Res Lab, Weapons & Mat Res, AMSRL, Aberdeen Proving Ground, MD 21005 USA. RP Mauritz, KA (reprint author), Univ So Mississippi, Dept Polymer Sci, So Stn, Hattiesburg, MS 39406 USA. NR 32 TC 28 Z9 29 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD OCT PY 2002 VL 43 IS 22 BP 5949 EP 5958 AR PII S0032-3861(02)00387-7 DI 10.1016/S0032-3861(02)00387-7 PG 10 WC Polymer Science SC Polymer Science GA 598HB UT WOS:000178269200017 ER PT J AU Robbins, RG Platt, SG Keirans, JE AF Robbins, RG Platt, SG Keirans, JE TI First report of Hyalomma marginatum isaaci Sharif (Acari : Ixodida : Ixodidae) from the Union of Myanmar, with a concurrent collection of H-hussaini Sharif SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article ID TICK C1 Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD OCT PY 2002 VL 104 IS 4 BP 1061 EP 1063 PG 3 WC Entomology SC Entomology GA 601GA UT WOS:000178437100024 ER PT J AU Paulsen, IT Seshadri, R Nelson, KE Eisen, JA Heidelberg, JF Read, TD Dodson, RJ Umayam, L Brinkac, LM Beanan, MJ Daugherty, SC Deboy, RT Durkin, AS Kolonay, JF Madupu, R Nelson, WC Ayodeji, B Kraul, M Shetty, J Malek, J Van Aken, SE Riedmuller, S Tettelin, H Gill, SR White, O Salzberg, SL Hoover, DL Lindler, LE Halling, SM Boyle, SM Fraser, CM AF Paulsen, IT Seshadri, R Nelson, KE Eisen, JA Heidelberg, JF Read, TD Dodson, RJ Umayam, L Brinkac, LM Beanan, MJ Daugherty, SC Deboy, RT Durkin, AS Kolonay, JF Madupu, R Nelson, WC Ayodeji, B Kraul, M Shetty, J Malek, J Van Aken, SE Riedmuller, S Tettelin, H Gill, SR White, O Salzberg, SL Hoover, DL Lindler, LE Halling, SM Boyle, SM Fraser, CM TI The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID MICROBIAL GENE IDENTIFICATION; ESCHERICHIA-COLI; SEQUENCE; PROTEIN; MACROPHAGES; ABORTUS; UREASE; SURVIVAL; WEAPONS; LOCUS AB The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified. C1 Inst Genom Res, Rockville, MD 20850 USA. Johns Hopkins Univ, Baltimore, MD 21218 USA. Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. USDA ARS, Natl Anim Dis Ctr, Ames, IA 50010 USA. Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Ctr Mol Med & Infect Dis, Blacksburg, VA 24061 USA. George Washington Univ, Sch Med, Dept Pharmacol & Microbiol, Washington, DC 20037 USA. George Washington Univ, Sch Med, Dept Trop Med, Washington, DC 20037 USA. RP Paulsen, IT (reprint author), Inst Genom Res, 9712 Med Ctr Dr, Rockville, MD 20850 USA. RI Read, Timothy/E-6240-2011; Paulsen, Ian/K-3832-2012; Nelson, William/E-9263-2016; Salzberg, Steven/F-6162-2011; OI Paulsen, Ian/0000-0001-9015-9418; Nelson, William/0000-0002-1873-3929; Salzberg, Steven/0000-0002-8859-7432; Heidelberg, John/0000-0003-0673-3224; Fraser, Claire/0000-0003-1462-2428; Eisen, Jonathan A./0000-0002-0159-2197 NR 50 TC 321 Z9 917 U1 1 U2 15 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 1 PY 2002 VL 99 IS 20 BP 13148 EP 13153 DI 10.1073/pnas.192319099 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 600LK UT WOS:000178391700117 PM 12271122 ER PT J AU Murphey, MD McRae, GA Fanburg-Smith, JC Temple, HT Levine, AM Aboulafia, AJ AF Murphey, MD McRae, GA Fanburg-Smith, JC Temple, HT Levine, AM Aboulafia, AJ TI Imaging of soft-tissue myxoma with emphasis on CT and MR and comparison of radiologic and pathologic findings SO RADIOLOGY LA English DT Article DE myxoma; soft tissues, CT; soft tissues, MR; soft tissues, neoplasms; soft tissues, US ID POLYOSTOTIC FIBROUS DYSPLASIA; INTRAMUSCULAR MYXOMA; JUXTAARTICULAR MYXOMA; MAZABRAUDS SYNDROME; WRIST GANGLIA; TUMORS; LIPOSARCOMA; CYSTS; BONE; FEATURES AB PURPOSE: To determine the imaging characteristics of soft-tissue myxoma, with emphasis on computed tomographic (CT) and magnetic resonance (MR) imaging findings and pathologic comparison. MATERIALS AND METHODS: Records of 45 pathologically confirmed soft-tissue myxomas in 44 patients were retrospectively reviewed. Patient demographics and radiographs (n = 20), bone scintigrams (n = 2), angiograms (n = 3), and ultrasonographic (US) (n = 6), CT (n = 14), and MR images (n = 33) were evaluated by two musculoskeletal radiologists with agreement by consensus for lesion location, lesion size, and intrinsic characteristics. RESULTS: Soft-tissue myxoma more commonly affected women (59%; average age 52 years) and manifested as a slowly enlarging (64%) painful (51%) mass. Lesions were most frequently intramuscular (82%) and involved the thigh (51%). An appearance similar to that of a cyst was seen at CT (at which the lesions demonstrated low attenuation) and at MR imaging (at which the lesions demonstrated markedly high signal intensity on T2-weighted images) in all cases because of the high water content of mucin that was seen histologically. The true solid architecture of these lesions was best depicted in all cases at US (at which the lesions were hypoechoic, not anechoic) and on MR images obtained with contrast material (at which the lesions demonstrated internal enhancement). A small amount of tissue similar to fat surrounding these intramuscular myxomas (71% at MR imaging) corresponded histologically (70%) to atrophy of surrounding muscle. CONCLUSION: Soft-tissue myxoma often demonstrates characteristic US, CT, and MR imaging findings, including intramuscular location, intrinsic high water content, and a surrounding rim of fat. C1 Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Dept Soft Tissue Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD USA. Univ Maryland, Sch Med, Dept Radiol, Baltimore, MD USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. Sinai Hosp, Inst Canc, Baltimore, MD USA. RP Murphey, MD (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, 6825 16th St NW,Bldg 54,Rm M-127A, Washington, DC 20306 USA. NR 48 TC 52 Z9 61 U1 2 U2 3 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD OCT PY 2002 VL 225 IS 1 BP 215 EP 224 DI 10.1148/radiol.2251011627 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 598FE UT WOS:000178264300033 PM 12355008 ER PT J AU Bucher, G AF Bucher, G TI Remembering the darkness: Women in Soviet prisons SO RUSSIAN REVIEW LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Bucher, G (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD OCT PY 2002 VL 61 IS 4 BP 651 EP 652 PG 2 WC History SC History GA 596UB UT WOS:000178183500039 ER PT J AU Iliadis, AA Jones, KA AF Iliadis, AA Jones, KA TI Part I - International Semiconductor Device Research Symposium ISDRS 2001 special issue - Foreword SO SOLID-STATE ELECTRONICS LA English DT Editorial Material C1 Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Iliadis, AA (reprint author), Univ Maryland, Dept Elect & Comp Engn, 2373 AV Williams Bldg, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2002 VL 46 IS 10 BP 1471 EP 1471 AR PII S0038-1101(02)00091-6 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 588EC UT WOS:000177687300001 ER PT J AU Gelmont, B Woolard, D Zhang, WD Globus, T AF Gelmont, B Woolard, D Zhang, WD Globus, T TI Electron transport within resonant tunneling diodes with staggered-bandgap heterostructures SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 01) CY DEC 05-07, 2001 CL WASHINGTON, D.C. SP IEEE, Electron Device Soc, USA, Res Off, Natl Sci Fdn, USA, Res Lab, NASA, Univ Maryland, Elect & Comp Engn Dept AB The electron transport physics within the conduction-band of resonant tunneling diodes with staggered-bandgap structure is analyzed. Here, the current-voltage characteristic for AlGaSb/InAs/AlGaSb double-barrier tunneling diodes is calculated in the framework of the six-band Kane model. This work demonstrates that the conduction-band electron transport is extremely dependent on the coupling between the conduction and valence bands and that an accurate estimate of current density requires the application of a multi-band model. In addition, the application of a multi-band model yields results that are in excellent agreement with existing experimental measurements on staggered-bandgap structures when well known material parameters are utilized. (C) 2002 Published by Elsevier Science Ltd. C1 Univ Virginia, Dept Elect Engn, Charlottesville, VA 22904 USA. USA, Res Lab, Res Off, Res Triangle Pk, NC 27709 USA. RP Gelmont, B (reprint author), Univ Virginia, Dept Elect Engn, Charlottesville, VA 22904 USA. NR 4 TC 11 Z9 11 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2002 VL 46 IS 10 BP 1513 EP 1518 AR PII S0038-1101(02)00097-7 DI 10.1016/S0038-1101(02)00097-7 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 588EC UT WOS:000177687300006 ER PT J AU Ali, HA Iliadis, AA Mulligan, RF Cresce, AVW Kofinas, P Lee, U AF Ali, HA Iliadis, AA Mulligan, RF Cresce, AVW Kofinas, P Lee, U TI Properties of self-assembled ZnO nanostructures SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 01) CY DEC 05-07, 2001 CL WASHINGTON, D.C. SP IEEE, Electron Device Soc, USA, Res Off, Natl Sci Fdn, USA, Res Lab, NASA, Univ Maryland, Elect & Comp Engn Dept ID BLOCK-COPOLYMER FILMS; NANOCLUSTERS AB The formation of self-assembled ZnO nanoclusters using diblock copolymers, is reported. The diblock copolymers, consisting of a majority polymer (norbornene) and a minority polymer (norbornene-dicarboxcylic acid), were synthesized with a block repeat unit ratio of 400/50, to obtain spherical microphase separation and hence a spherical morphology for the metal oxide nanoclusters. The self-assembly of the inorganic nanoparticles was achieved at room temperature in the liquid phase, using ZnCl2 precursor dopant and wet chemical processing compatible with semiconductor manufacturing to convert to ZnO. FTIR and XPS spectroscopy, confirmed the association of the ZnCl2 precursor with the minority block and the formation of ZnO, while TEM showed the spherical morphology of ZnO nanoparticles as targeted, and a relatively narrow size distribution ranging between 7 and 15 nm. (C) 2002 Published by Elsevier Science Ltd. C1 Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. Univ Maryland, Dept Mat & Nucl Engn, College Pk, MD 20742 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Iliadis, AA (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RI Cresce, Arthur/K-3958-2013; Kofinas, Peter/A-8204-2012 OI Cresce, Arthur/0000-0002-3894-6083; Kofinas, Peter/0000-0001-6657-3037 NR 11 TC 27 Z9 28 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2002 VL 46 IS 10 BP 1639 EP 1642 AR PII S0038-1101(02)00118-1 DI 10.1016/S0038-1101(02)00118-1 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 588EC UT WOS:000177687300027 ER PT J AU Sarney, WL Salamanca-Riba, L Bruno, JD Tober, RL AF Sarney, WL Salamanca-Riba, L Bruno, JD Tober, RL TI Strain relaxation in AlSb/GaSb heterostructures SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 01) CY DEC 05-07, 2001 CL WASHINGTON, D.C. SP IEEE, Electron Device Soc, USA, Res Off, Natl Sci Fdn, USA, Res Lab, NASA, Univ Maryland, Elect & Comp Engn Dept DE antimonides; strain relaxation; misfit dislocations ID LATTICE-MISMATCH; CASCADE AB Several GaSb-based infrared devices require the growth of dislocation-free AlSb layers lattice matched to the GaSb substrate. In this work, we characterize the strain relaxation of AlSb films grown on GaSb by molecular beam epitaxy. We grew several AlSb films, ranging in thickness from 40 Angstrom to 2 mum, on (0 0 1)-GaSb substrates. Despite a Matthews-Blakeslee critical thickness of approximately 200, our results indicate that the AlSb remains highly strained for film thicknesses above 1000 Angstrom and even retains significant strain (similar to18%) for 2 mum AlSb films. We demonstrate that the simple use of Bragg's Law for predicting the strain from X-ray rocking curve data is insufficient for the very thin films. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 USA, Sensors & Electron Devices Directorate, Res Lab, AMSRL,SE,EI, Adelphi, MD 20783 USA. Univ Maryland, Dept Mat & Nucl Engn, College Pk, MD 20742 USA. RP Sarney, WL (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, AMSRL,SE,EI, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Salamanca-Riba, Lourdes/B-3785-2009 OI Salamanca-Riba, Lourdes/0000-0001-8155-6403 NR 12 TC 3 Z9 4 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2002 VL 46 IS 10 BP 1643 EP 1649 AR PII S0038-1101(02)00119-3 DI 10.1016/S0038-1101(02)00119-3 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 588EC UT WOS:000177687300028 ER PT J AU Keith, B LeBoeuf, J Meese, MJ Malinowski, JC Gallagher, M Efflandt, S Hurley, J Green, C AF Keith, B LeBoeuf, J Meese, MJ Malinowski, JC Gallagher, M Efflandt, S Hurley, J Green, C TI Assessing students' understanding of human behavior: A multidisciplinary outcomes-based approach for the design and assessment of an academic program goal SO TEACHING SOCIOLOGY LA English DT Article ID SOCIOLOGY; PRESTIGE AB In this paper, we present a strategy for the curricular design and assessment of one multidisciplinary program goal (understanding human behavior). We show how assessing a desired outcome requires attention to four specific areas: organizational context, the articulation of a learning model, program design and implementation, and outcomes assessment. Our findings, based on multiple indicators gathered over time and including both summative and formative measures, suggest that our graduates are generally achieving the outcomes established for them. We discuss how our results are used to inform decision-makers, and how inconsistencies discovered between the program's desired outcomes and students' actual achievements are managed within the framework of the program. Finally, we highlight several lessons learned as a result of this intensive process, linking its benefits to programs within sociology and other disciplines. C1 US Mil Acad, Off Dean, W Point, NY 10996 USA. RP Keith, B (reprint author), US Mil Acad, Off Dean, W Point, NY 10996 USA. NR 56 TC 3 Z9 3 U1 0 U2 0 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1307 NEW YORK AVE NW #700, WASHINGTON, DC 20005-4712 USA SN 0092-055X J9 TEACH SOCIOL JI Teach. Sociol. PD OCT PY 2002 VL 30 IS 4 BP 430 EP 453 DI 10.2307/3211503 PG 24 WC Education & Educational Research; Sociology SC Education & Educational Research; Sociology GA 604EL UT WOS:000178603300005 ER PT J AU Keith, B AF Keith, B TI Untitled SO TEACHING SOCIOLOGY LA English DT Editorial Material C1 US Mil Acad, W Point, NY 10996 USA. RP Keith, B (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1307 NEW YORK AVE NW #700, WASHINGTON, DC 20005-4712 USA SN 0092-055X J9 TEACH SOCIOL JI Teach. Sociol. PD OCT PY 2002 VL 30 IS 4 PG 1 WC Education & Educational Research; Sociology SC Education & Educational Research; Sociology GA 604EL UT WOS:000178603300001 ER PT J AU Stephens, HAF Klaythong, R Sirikong, M Vaughn, DW Green, S Kalayanarooj, S Endy, TP Libraty, DH Nisalak, A Innis, BL Rothman, AL Ennis, FA Chandanayingyong, D AF Stephens, HAF Klaythong, R Sirikong, M Vaughn, DW Green, S Kalayanarooj, S Endy, TP Libraty, DH Nisalak, A Innis, BL Rothman, AL Ennis, FA Chandanayingyong, D TI HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais SO TISSUE ANTIGENS LA English DT Article DE HLA; class I; allele; associations; secondary; dengue; virus; infections ID T-CELL RESPONSES; HEMORRHAGIC-FEVER; PEPTIDE BINDING; INTERFERON-GAMMA; SOUTHEAST-ASIA; POLYMORPHISM; EPITOPES; RECOGNITION; LYMPHOCYTES; RECEPTOR AB Little is known of the role of classical HLA-A and -B class I alleles in determining resistance, susceptibility, or the severity of acute viral infections. Appropriate paradigms for immunogenetic studies of acute viral infections are dengue fever (DF) and dengue hemorrhagic fever (DHF). Both primary and secondary infections with dengue virus (DEN) serotypes 1, 2, 3 or 4, can result in either clinically less severe DF or the more severe DHF. In secondary exposures, a memory response is induced in immunologically primed individuals, which can both clear the infecting dengue virus and contribute to its pathology. In a case-control study of 263 ethnic Thai patients infected with either DEN-1, -2, -3 or -4, we detected HLA class I associations with secondary infections, but not in immunologically naive patients with primary infections. HLA-A*0203 was associated with the less severe DF, regardless of the secondary infecting virus serotype. By contrast, HLA-A*0207 was associated with susceptibility to the more severe DHF in patients with secondary DEN-1 and DEN-2 infections only. Conversely, HLA-B*51 was associated with the development of DHF in patients with secondary infections, and HLA-B*52 was associated with DF in patients with secondary DEN-1 and DEN-2 infections. Moreover, HLA-B44, B62, B76 and B77 also appeared to be protective against developing clinical disease after secondary dengue virus infection. These results confirm that classical HLA class I alleles are associated with the clinical outcome of exposure to dengue virus, in previously exposed and immunologically primed individuals. C1 Univ Coll, Inst Urol & Nephrol, London, England. Mahidol Univ, Siriraj Hosp & Med Sch, Dept Transfus Med, Bangkok 10700, Thailand. Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. Queen Sirikit Natl Hosp Child Hlth, Bangkok, Thailand. RP Stephens, HAF (reprint author), UCL, Middlesex Hosp, Inst Urol & Nephrol, Mortimer St, London W1N 8AA, England. EM h.stephens@ucl.ac.uk FU NIAID NIH HHS [P01AI34533] NR 41 TC 124 Z9 131 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0001-2815 J9 TISSUE ANTIGENS JI Tissue Antigens PD OCT PY 2002 VL 60 IS 4 BP 309 EP 318 DI 10.1034/j.1399-0039.2002.600405.x PG 10 WC Cell Biology; Immunology; Pathology SC Cell Biology; Immunology; Pathology GA 624CY UT WOS:000179743800005 PM 12472660 ER PT J AU Elsayed, NM Gorbunov, NV Mayorga, MA Kagan, VE Januszkiewicz, AJ AF Elsayed, NM Gorbunov, NV Mayorga, MA Kagan, VE Januszkiewicz, AJ TI Significant pulmonary response to a brief high-level, nose-only nitrogen dioxide exposure: An interspecies dosimetry perspective SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE nitrogen dioxide; nose-only exposure; lung injury; NO2-mediated free radical formation; inspired dose; antioxidant depletion; lipid peroxidation; bronchoalveolar lavage; rats; sheep; interspecies dosimetery; species-specific response ID NITRIC-OXIDE; LIPID-PEROXIDATION; LUNG INJURY; RESONANCE; TOXICITY; CELLS; INHALATION; HEMOGLOBIN; COMPLEXES; FORMS AB Brief, high-level nitrogen dioxide (NO2) exposures are major hazards during fires and heat-generating explosions. To characterize the lung response to a brief high-level NO2 exposure, we exposed two groups (n = 5) of 325-375 g, male, Sprague-Dawley rats to either 200 +/- 5 ppm (376 +/- 9 mg/m(3)) NO2 or room air for 15 min. The rats were nose-only exposed in a multiport exposure chamber fitted with pressure transducers to monitor their respiration during exposure. One hour after exposure, we euthanized the rats, collected blood samples, lavaged the lungs with warm saline, and then excised them. One lung lobe was cooled to -196degreesC and used for low-temperature electron paramagentic resonance (EPR) analysis. The remainder was homogenized and used for biochemical analyses. Inspired minute ventilation (V-i) during exposure decreased 59% (p < 0.05). Calculated total inspired dose was 0.880 mg NO2. In lung lavage, both total and alveolar macrophage cell counts declined (similar to75%, p < 0.05), but epithelial cell count increased 8.5-fold. Lung weight increased 40% (p < 0.05) after exposure. In the blood, potassium and methemoglobin increased 45 and 18% (p < 0.05), respectively; glucose, lactate, and total hemoglobin were not altered significantly. EPR analysis of lung tissue revealed hemoglobin oxidation and carbon-centered radical formation. Vitamins E and C and uric acid were depleted, and lipid peroxidation measured by three different methods (TBARS, conjugated dienes, and fluorescent peroxidation end products) was elevated, but total protein, DNA, and lipid contents were unchanged. These observations combined demonstrate that a brief (15 min) high-level (200 ppm) NO2 exposure of rats was sufficient to cause significant damage. However, comparison of the exposure dose normalized to rat body weight with previously reported sheep and estimated human values revealed significant differences. This raises a question about interspecies dosimetry and species-specific responses when animal data are extrapolated to humans and used for safety standard setting, particularly with high-level brief exposures. (C) 2002 Elsevier Science (USA). C1 Walter Reed Army Inst Res, Div Med, Dept Resp Res, Silver Spring, MD 20910 USA. Univ Pittsburgh, Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15238 USA. RP Elsayed, NM (reprint author), Hurley Consulting Associates, 1 Main St, Chatham, NJ 07928 USA. NR 63 TC 2 Z9 4 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 1 PY 2002 VL 184 IS 1 BP 1 EP 10 DI 10.1006/taap.2002.9487 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 607MZ UT WOS:000178796500001 PM 12392963 ER PT J AU Logan, TP Shutz, M Schulz, SM Railer, R Ricketts, KM Casillas, RR AF Logan, TP Shutz, M Schulz, SM Railer, R Ricketts, KM Casillas, RR TI Application and detection of C-14-HD in two mouse models SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE C-14; CD1-haired mouse; concentration/time (C-T) values; cutaneous exposure; protection; SKH-hairless mouse; sulfur mustard (HD) ID HAIRLESS GUINEA-PIG; SULFUR MUSTARD; VAPOR AB The CD1-haired mouse and the SKH-hairless mouse are two animal models that have been used to evaluate sulfur mustard (HD) exposure and protection in our laboratory. In a recent study we observed that a substance P inhibitor protected the haired mouse ear against an HD solution, but the same drug was not successful in protecting the hairless mouse against HD vapor. This experiment prompted us to compare HD exposures between these models. We determined the C-14 content in the skin after exposures to HD containing C-14-HD. Rate curves were generated for applications of (1) HD in methylene chloride to the haired mouse ear, (2) HD in methylene chloride to the hairless mouse dorsal skin; and (3) saturated HD vapor to the hairless mouse dorsal skin for 6 min. The curves showed a reduction in C-14 disintegrations per min in animals euthanized 0 to 2 h postexposure. The largest percentage of decrease of C-14 content in skin occurred within 30 min of HD challenge for all exposures. An 8-mm skin-punch biopsy and a 14-mm annular skin section surrounding the region of the 8-mm skin punch were taken from the hairless mouse dorsal skin exposed to HD in methylene chloride. The ratio of the C-14 content in the 8-mm skin punch to that in the surrounding 14-mm annular skin section was 7.3, demonstrating that the HD application spreads beyond the initially biopsied site. A concentration / time value of 6.3 mug/cm(2)/min was determined by counting skin C-14 disintegrations per minute in animals euthanized immediately after exposure to saturated HD vapor Determinations of the amount of HD showed that similar quantities of HD, 0.4 mg, were detected on each model. These results contribute to a better quantitative understanding of HD application in the haired and hairless mouse models. C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Logan, TP (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD OCT-DEC PY 2002 VL 12 IS 4 BP 293 EP 300 DI 10.1080/10517230290075495 PG 8 WC Toxicology SC Toxicology GA 619YF UT WOS:000179504700005 PM 20021170 ER PT J AU Radil, K Howard, S Dykas, B AF Radil, K Howard, S Dykas, B TI The role of radial clearance on the performance of foil air bearings SO TRIBOLOGY TRANSACTIONS LA English DT Article; Proceedings Paper CT ASME/STLE Tribology Conference CY OCT 27-30, 2002 CL CANCUN, MEXICO SP ASME, STLE DE foil air bearing; gas bearing; turbomachinery ID JOURNAL BEARINGS; LOAD AB Load capacity tests were conducted to determine how radial clearance variations affect the load capacity coefficient of foil air bearings. Two Generation III foil air bearings with the same design but possessing different initial radial clearances were tested at room temperature against an as-ground PS304 coated journal operating at 30000 rpm. Increases in radial clearance were accomplished by reducing the journal's outside diameter via an in-place grinding system. Front each load capacity test the bearing load capacity coefficient was calculated from the rule-of-thumb (ROT) model developed for foil air bearings. The test results indicate that, in terms of the load capacity coefficient, radial clearance has a direct impact on the performance of the foil air bearing. Each test bearing exhibited an optimum radial clearance that resulted in a maximum load capacity coefficient. Relative to this optimum value are two separate operating regimes that are governed by different modes of failure. Bearings operating with radial clearances less than the optimum exhibit load capacity coefficients that are a strong function of radial clearance and are prone to a thermal runaway failure mechanism and bearing seizure. Conversely, a bearing operating with a radial clearance m,ice the optimum suffered only a 20% decline in its maximum load capacity coefficient and did not experience any thermal management problems. However, it is unknown to what degree these changes in radial clearance had on other performance parameters, such (is the stiffness and damping properties of the bearings. C1 USA, Cleveland, OH 44135 USA. NASA, Glenn Res Ctr, Cleveland, OH USA. Case Western Reserve Univ, Cleveland, OH 44106 USA. RP Radil, K (reprint author), USA, Cleveland, OH 44135 USA. NR 19 TC 41 Z9 45 U1 3 U2 10 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 840 BUSSE HIGHWAY, PARK RIDGE, IL 60068 USA SN 1040-2004 J9 TRIBOL T JI Tribol. Trans. PD OCT PY 2002 VL 45 IS 4 BP 485 EP 490 DI 10.1080/10402000208982578 PG 6 WC Engineering, Mechanical SC Engineering GA 613NH UT WOS:000179138000009 ER PT J AU Nitatpattana, N Henrich, T Palabodeewat, S Tangkanakul, W Poonsuksombat, D Chauvancy, G Barbazan, P Yoksan, S Gonzalez, JP AF Nitatpattana, N Henrich, T Palabodeewat, S Tangkanakul, W Poonsuksombat, D Chauvancy, G Barbazan, P Yoksan, S Gonzalez, JP TI Hantaan virus antibody prevalence in rodent populations of several provinces of northeastern Thailand SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Hantavirus; rodent; Thailand ID VOLES CLETHRIONOMYS-GLAREOLUS; HANTAVIRUS PULMONARY SYNDROME; NEPHROPATHIA-EPIDEMICA; FAMILY BUNYAVIRIDAE; HEMORRHAGIC-FEVER; ETIOLOGIC AGENT; UNITED-STATES; SEQUENCES; INFECTION; OUTBREAK AB We conducted a serological survey of 632 rodents from the northeast region of Thailand in order to assess the presence of Hantaan-like viruses that may be a risk to the human population. Rodents were collected from rice fields, houses and domestic gardens in five northeastern provinces and tested for IgG reacting sera to Hantaan antigen using enzyme-linked immunoassays. The overall prevalence of Hantavirus infection in rodents was 2.1% (13/632). Species that tested positive included Bandicota indica (4.3% positive within species), Rattus exulans (2.1%), R. losea (1.6%) and R. rattus (0.9%). Species such as R. exulans and R. losea are candidate hosts of unidentified Hantaan-like viruses in Thailand. C1 Mahidol Univ, Ctr Emerging Viral Dis, Ctr Vaccine Dev Res, Bangkok, Thailand. Yale Univ, Sch Med, New Haven, CT USA. Minist Publ Hlth, Dept Communicable Dis Control, Nonthaburi, Thailand. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Inst Rech Dev, Paris, France. RP Gonzalez, JP (reprint author), IRD Mahidol Univ, Ctr Vaccine Dev Res, Nakhon Pathom 73170, Thailand. OI Gonzalez, Jean-Paul/0000-0003-3063-1770 NR 29 TC 9 Z9 9 U1 0 U2 1 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD OCT PY 2002 VL 7 IS 10 BP 840 EP 845 DI 10.1046/j.1365-3156.2002.00830.x PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 599MN UT WOS:000178338900005 PM 12358618 ER PT J AU Feng, XH Taylor, S Renshaw, CE Kirchner, JW AF Feng, XH Taylor, S Renshaw, CE Kirchner, JW TI Isotopic evolution of snowmelt - 1. A physically based one-dimensional model SO WATER RESOURCES RESEARCH LA English DT Article DE snowmelt; oxygen isotopes; modeling; spring runoff ID HYDROGRAPH SEPARATION; RUNOFF; WATER; FLOW; TRANSPORT; MELTWATER; CATCHMENT; EXCHANGE; TERRAIN; MELT AB [1] The O-18/O-16 ratio of snowmelt from a seasonal snowpack typically increases with time as the melting process progresses. This temporal evolution is caused by isotopic exchange between liquid and ice as meltwater percolates down the snow column. Consequently, hydrograph separations of spring runoff using the bulk snow composition as the new water end-member will be erroneous. Accurate determinations of the new water input should take into account the temporal variation of the snowmelt. Here we present a one-dimensional (1-D) physically based model for the isotopic evolution of snowmelt. Two parameters, the effective rate of isotopic exchange between water and ice and the ice to liquid ratio of the exchange system, are important for controlling the range and temporal pattern of the isotopic variation in snowmelt. For all plausible values of these parameters the modeled isotopic signature of snowmelt changes by 1-4parts per thousand as snowmelt progresses. These isotopic shifts will affect the results of hydrograph separations. C1 Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Feng, XH (reprint author), Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. RI Kirchner, James/B-6126-2009 OI Kirchner, James/0000-0001-6577-3619 NR 35 TC 19 Z9 20 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD OCT PY 2002 VL 38 IS 10 AR 1217 DI 10.1029/2001WR000814 PG 8 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 637PJ UT WOS:000180521100035 ER PT J AU Taylor, S Feng, XH Renshaw, CE Kirchner, JW AF Taylor, S Feng, XH Renshaw, CE Kirchner, JW TI Isotopic evolution of snowmelt - 2. Verification and parameterization of a one-dimensional model using laboratory experiments SO WATER RESOURCES RESEARCH LA English DT Article DE snowmelt; oxygen 18 composition; laboratory experiments; isotopic exchange rate constant ID HYDROGRAPH SEPARATION; MELT AB [1] Three controlled cold room experiments were conducted to verify and parameterize a one-dimensional (1-D) model that simulates the isotopic composition of meltwater exiting the base of a snowpack. In the model, snow melts at the surface at a constant rate, and water percolates down the column while exchanging isotopically with ice. The effective rate of isotopic exchange and hence the isotopic composition of the melt at a given time is determined by the exchange rate constant kr, the height of the original snowpack, the percolation velocity u*, and the liquid to ice ratio in the exchange system. The experiments were designed to have different effective rates of exchange by varying the height of the snow column and the melt rate. Fitting the model to each of the experiments yielded kr values that fall in a narrow range, 0.14 to 0.17 hr(-1), confirming that kr is an intrinsic rate constant for isotopic exchange. Knowing this value is important for developing future models, in which more complicated hydrological conditions are considered. C1 Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Taylor, S (reprint author), Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. RI Kirchner, James/B-6126-2009 OI Kirchner, James/0000-0001-6577-3619 NR 16 TC 6 Z9 6 U1 1 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD OCT PY 2002 VL 38 IS 10 AR 1218 DI 10.1029/2001WR000815 PG 8 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 637PJ UT WOS:000180521100036 ER PT J AU Akozbek, N Iwasaki, A Becker, A Scalora, M Chin, SL Bowden, CM AF Akozbek, N Iwasaki, A Becker, A Scalora, M Chin, SL Bowden, CM TI Third-harmonic generation and self-channeling in air using high-power femtosecond laser pulses SO PHYSICAL REVIEW LETTERS LA English DT Article ID 3RD-HARMONIC GENERATION; MOVING FOCUS; PROPAGATION; FILAMENTATION; IONIZATION; FIELDS AB It is shown, both theoretically and experimentally, that during laser pulse filamentation in air an intense ultrashort third-harmonic pulse is generated forming a two-colored filament. The third-harmonic pulse maintains both its peak intensity and energy over distances much longer than the characteristic coherence length. We argue that this is due to a nonlinear phase-locking mechanism between the two pulses in the filament and is independent of the initial material wave-vector mismatch. A rich spatiotemporal propagation dynamics of the third-harmonic pulse is predicted. Potential applications of this phenomenon to other parametric processes are discussed. C1 Time Domain Corp, Huntsville, AL 35806 USA. USA, Aviat & Missile Command, AMSAM WS RD ST, Huntsville, AL 35898 USA. Univ Laval, Dept Phys Genie Phys & Opt, Quebec City, PQ G1K 7P4, Canada. Univ Laval, Ctr Opt Photon & Laser, Quebec City, PQ G1K 7P4, Canada. Univ Bielefeld, Fak Phys, D-33501 Bielefeld, Germany. Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany. RP Akozbek, N (reprint author), Time Domain Corp, 7057 Old Madison Pike, Huntsville, AL 35806 USA. RI Becker, Andreas/K-4402-2013 NR 21 TC 176 Z9 182 U1 6 U2 32 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 30 PY 2002 VL 89 IS 14 AR 143901 DI 10.1103/PhysRevLett.89.143901 PG 4 WC Physics, Multidisciplinary SC Physics GA 595BP UT WOS:000178087200018 PM 12366048 ER PT J AU Onorato, M Osborne, AR Serio, M Resio, D Pushkarev, A Zakharov, VE Brandini, C AF Onorato, M Osborne, AR Serio, M Resio, D Pushkarev, A Zakharov, VE Brandini, C TI Freely decaying weak turbulence for sea surface gravity waves SO PHYSICAL REVIEW LETTERS LA English DT Article ID CAPILLARY WAVES; OCEAN; SPECTRUM; RANGE AB We study the long-time evolution of deep-water ocean surface waves in order to better understand the behavior of the nonlinear interaction processes that need to be accurately predicted in numerical models of wind-generated ocean surface waves. Of particular interest are those nonlinear interactions which are predicted by weak turbulence theory to result in a wave energy spectrum of the form of \k\(-2.5). We numerically implement the primitive Euler equations for surface waves and demonstrate agreement between weak turbulence theory and the numerical results. C1 Univ Turin, Dipartimento Fis Gen, I-10125 Turin, Italy. USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. Waves & Solitons LLC, Phoenix, AZ 85045 USA. LD Landau Theoret Phys Inst, Moscow 117334, Russia. Univ Arizona, Dept Math, Tucson, AZ 85721 USA. LaMMA, Reg Toscana, I-50013 Florence, Italy. RP Onorato, M (reprint author), Univ Turin, Dipartimento Fis Gen, Via Pietro Giuria 1, I-10125 Turin, Italy. RI Onorato, Miguel/G-7104-2012; Zakharov, Vladimir/F-1461-2016; Pushkarev, Andrei/I-8290-2016 OI Onorato, Miguel/0000-0001-9141-2147; Pushkarev, Andrei/0000-0001-9310-5888 NR 31 TC 58 Z9 59 U1 1 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 30 PY 2002 VL 89 IS 14 AR 144501 DI 10.1103/PhysRevLett.89.144501 PG 4 WC Physics, Multidisciplinary SC Physics GA 595BP UT WOS:000178087200020 PM 12366050 ER PT J AU Williams, AJ Dave, JR Lu, XM Ling, G Tortella, FC AF Williams, AJ Dave, JR Lu, XM Ling, G Tortella, FC TI Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE conantokin-G; neuronal culture; staurosporine ID THERAPEUTIC WINDOW; CONANTOKIN-G; ISCHEMIA AB Staurosporine-induced apoptosis was associated with a 20% cellular survival rate in primary rat forebrain cultures. Treatment with the NR2B subunit-selective NMDA receptor antagonist conantokin-G (0.1 - 1 muM) increased the survival rate up to 78%. No protection was provided by the nonselective NMDA receptor antagonist dizocilpine (0.01 - 10 muM) but 34-64% cellular survival was provided by ifenprodil (0.01 -10 muM), another NR2B subunit-selective antagonist. These results suggest a novel anti-apoptotic mechanism linked to the NR2B receptor subunit. Published by Elsevier Science B.V. C1 Walter Reed Army Inst Res, Dept Neuropharmacol & Mol Biol, Div Neurosci, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Williams, AJ (reprint author), Walter Reed Army Inst Res, Dept Neuropharmacol & Mol Biol, Div Neurosci, Silver Spring, MD 20910 USA. NR 6 TC 23 Z9 26 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD SEP 27 PY 2002 VL 452 IS 1 BP 135 EP 136 AR PII S0014-2999(02)02327-0 DI 10.1016/S0014-2999(02)02327-0 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 601TE UT WOS:000178463400015 PM 12323394 ER PT J AU Varela-Rey, M Montiel-Duarte, C Oses-Prieto, JA Lopez-Zabalza, MJ Jaffrezou, JP Rojkind, M Iraburu, MJ AF Varela-Rey, M Montiel-Duarte, C Oses-Prieto, JA Lopez-Zabalza, MJ Jaffrezou, JP Rojkind, M Iraburu, MJ TI p38 MAPK mediates the regulation of alpha 1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells SO FEBS LETTERS LA English DT Article DE p38 MAPK; TNF-alpha; TGF-beta; hepatic stellate cells; A-SMase; alpha 1(I) procollagen ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASES; GROWTH-FACTOR BETA(1); COLLAGEN GENE; DEPENDENT MECHANISM; SIGNALING PATHWAYS; EXPRESSION; PROLIFERATION; INTERLEUKIN-6; APOPTOSIS AB The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor alpha (TNF-alpha)mediated down-regulation of col1a1 gene was studied. TNF-alpha increased extracellular-regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on alpha1(I) procollagen (col1a1) mRNA levels. Phosphorylation of p38 MAPK was decreased in response to TNT-alpha and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels. Transforming growth factor beta (TGF-beta) increased p38 MAPK phosphorylation and SB203580 prevented the induction of col1a1 mRKA levels by TGF-beta. These results suggest that p38 MAPK plays an important role in regulating the expression of col1a1 in hepatic stellate cells in response to cytokines. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. C1 Univ Navarra, Dept Biochem, Pamplona 31008, Spain. INSERM, E9910, Inst Claudius Regaud, F-31052 Toulouse, France. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Iraburu, MJ (reprint author), Univ Navarra, Dept Biochem, C-Irunlarrea 1, Pamplona 31008, Spain. RI Collados, Mari Jose/B-4464-2012; OI Montiel Duarte, Cristina/0000-0002-9144-8809; Oses-Prieto, Juan/0000-0003-4759-2341 FU NIAAA NIH HHS [AA 10541] NR 29 TC 52 Z9 60 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 J9 FEBS LETT JI FEBS Lett. PD SEP 25 PY 2002 VL 528 IS 1-3 BP 133 EP 138 AR PII S0014-5793(02)03276-3 DI 10.1016/S0014-5793(02)03276-3 PG 6 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 598NL UT WOS:000178282500026 PM 12297293 ER PT J AU Stocker, DJ Kelly, WF Fitzpatrick, TM Bernet, VJ Burch, HB AF Stocker, DJ Kelly, WF Fitzpatrick, TM Bernet, VJ Burch, HB TI Bilateral external laryngoceles following radioiodine ablation for Graves disease SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID THERAPY AB A 28-year-old trumpet player underwent multiple treatments with radioactive iodine for Graves disease associated with an unusually large goiter. Following his second treatment, the patient developed acute neck pain and swelling. Radiographic studies and a laryngoscopy demonstrated bilateral symptomatic external laryngoceles, a very rare entity, not previously known to be associated with radioiodine treatment or Graves disease. The patient's profession placed him at risk for the development of a laryngocele, but the temporal relationship to goiter regression following radioiodine therapy suggests that this occurred as a result of this treatment. The patient's disease was managed nonsurgically, and he has subsequently done well. This represents the first known association of symptomatic laryngocele with radioiodine treatment for Graves disease. C1 Walter Reed Army Med Ctr, Endocrine Metab Serv, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Pulm Crit Care Serv, Dept Med, Washington, DC 20307 USA. RP Stocker, DJ (reprint author), Walter Reed Army Med Ctr, Endocrine Metab Serv, Dept Med, Washington, DC 20307 USA. NR 19 TC 4 Z9 4 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD SEP 23 PY 2002 VL 162 IS 17 BP 2007 EP 2009 DI 10.1001/archinte.162.17.2007 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 594TM UT WOS:000178067100012 PM 12230425 ER PT J AU Strader, J Everitt, HO Danford, S AF Strader, J Everitt, HO Danford, S TI Variable stars in the core of the globular cluster M3 SO MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY LA English DT Article DE techniques : image processing; stars : variables : other; globular clusters : general; globular clusters : individual : M3 ID IMAGE SUBTRACTION; PHOTOMETRY AB We present the results of a survey for variable stars in the core of the globular cluster M3. Our findings include the discovery of 11 new or suspected variables, including a possible W Vir, and the first period determinations for 13 previously known variables. C1 Duke Univ, Dept Phys, Durham, NC 27708 USA. Univ Calif Santa Cruz, Univ Calif Observ, Lick Observ, Santa Cruz, CA 95064 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ N Carolina, Dept Phys & Astron, Greensboro, NC 27402 USA. RP Strader, J (reprint author), Duke Univ, Dept Phys, Box 90305, Durham, NC 27708 USA. RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 15 TC 9 Z9 9 U1 0 U2 0 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0035-8711 J9 MON NOT R ASTRON SOC JI Mon. Not. Roy. Astron. Soc. PD SEP 21 PY 2002 VL 335 IS 3 BP 621 EP 627 DI 10.1046/j.1365-8711.2002.05645.x PG 7 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 598NR UT WOS:000178283100016 ER PT J AU Wolfenstine, J AF Wolfenstine, J TI Creep resistance comparison of two solid oxygen fuel cell electrolytes with the fluorite structure: cubic zirconia and doped-ceria SO JOURNAL OF POWER SOURCES LA English DT Article DE creep; diffusion; oxide; fuel cell; fluorite ID LANTHANUM GALLATE; STATE ELECTROLYTE; CERAMICS; TECHNOLOGY; BEHAVIOR C1 USA, Res Lab, AMSRL, SE,DC, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, AMSRL, SE,DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 23 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 18 PY 2002 VL 111 IS 1 BP 173 EP 175 AR PII S0378-7753(02)00064-2 DI 10.1016/S0378-7753(02)00064-2 PG 3 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 599HV UT WOS:000178329000020 ER PT J AU Douglas, TA Chamberlain, CP Blum, JD AF Douglas, TA Chamberlain, CP Blum, JD TI Land use and geologic controls on the major elemental and isotopic (delta N-15 and Sr-87/Sr-86) geochemistry of the Connecticut River watershed, USA SO CHEMICAL GEOLOGY LA English DT Article DE nitrogen isotopes; strontium isotopes; riverine geochemistry; weathering; Connecticut River; Atlantic salmon ID STRONTIUM ISOTOPES; NEW-HAMPSHIRE; SYSTEM; NITROGEN; RATES; SR; CATCHMENTS; POLLUTION; NITRATE; MARKERS AB We studied the relationship between land use, geology and water chemistry in the Connecticut River watershed of northeastern USA by combining Geographic Information Systems (GIS) with nitrogen and strontium isotopic analyses and major cation and anion geochemistry. River water was sampled at 35 sites in the summer and fall of 1998 and the spring of 1999 in an attempt to distinguish spatial and temporal changes in geochemical signatures related to land use and bedrock geology. We coupled Sr-87/Sr-86 values and major element concentrations from river water to quantify the relationship between bedrock geology and riverine geochemistry. The results in our study show that strontium isotopes of tributary waters reflect their catchment bedrock lithology. Our results also suggest that major cations in the Connecticut River water are dominated by carbonate weathering despite the limited presence of calcareous metasedimentary rocks ( similar to 10% of watershed bedrock). In addition, the relative contribution of carbonate to silicate weathering increases downriver as a result of input from tributaries draining Paleozoic carbonate-bearing rocks. In contrast, nitrate concentrations and nitrogen isotopic ratios of nitrate in water were highly variable. Nitrate concentrations were highest for tributaries draining developed and agricultural sites, suggesting anthropogenic inputs. However, it was difficult to determine the source of nitrate because of the wide scatter in the nitrogen isotopic data, which for the most part did not correlate with land use. The only systematic trends in nitrogen isotopic values are found in waters collected in the summer. However, these data show that delta(15)N values of nitrate from agricultural sites were lower than delta(15)N values of nitrate from forested sites, a result that is inconsistent with previous studies. Our study suggests that strontium isotopes provide a better biomarker for tracking Atlantic salmon (Salmo salar) than nitrogen isotopes because unlike N-15/N-14 ratios, Sr-87/Sr-86 ratios are both predictable and seasonally constant in water. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA. RP Douglas, TA (reprint author), USA, Cold Reg Res & Engn Lab, POB 35170,Bldg 4070, Ft Wainwright, AK 99703 USA. NR 40 TC 25 Z9 25 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 J9 CHEM GEOL JI Chem. Geol. PD SEP 16 PY 2002 VL 189 IS 1-2 BP 19 EP 34 AR PII S0009-2541(02)00047-5 DI 10.1016/S0009-2541(02)00047-5 PG 16 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 592NA UT WOS:000177942700002 ER PT J AU Matyas, GR Rao, M Alving, CR AF Matyas, GR Rao, M Alving, CR TI Induction and detection of antibodies to squalene II. Optimization of the assay for murine antibodies SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE squalene; antibody detection; enzyme-linked immunosorbent assays; monoclonal antibodies AB An improved high throughput assay for measuring marine antibodies to squalene (SQE) is described. The assay is highly reproducible and sensitive and can detect 80 mg/ml of antibody to SQE. The assay, an ELISA, is similar to our previously described assay in which plates containing PVDF membranes were used [J. Immunol. Methods 245 (2000) 1]. The PVDF plates worked well for detection of murine monoclonal antibodies (mAbs) to SQE, but substantial PVDF plate variation was observed, resulting in significant loss of signal and reproducibility between different lots of plates. In the new assay, the PVDF plates were replaced with Costar round bottom 96-well sterile tissue culture plates. These latter plates, which are not normally used for ELISA assay, gave high absorbances for monoclonal antibodies and anti-SQE serum binding to SQE and low absorbances for solvent-treated wells. Other commercially available polystyrene ELISA plates were unsuitable, in that either the background was high or the absorbance for antibodies binding to SQE was low, or both. This change in plate from PVDF to polystyrene allowed the use of an ELISA plate washer, which dramatically increased the throughput rate over the hand-washed PVDF plates. The improved assay also replaced fetal bovine serum (FBS), which contained SQE in lipoproteins, with fatty acid-free bovine serum albumin (BSA) as the blocker/diluent. Fifteen nanomoles of SQE were selected as the optimal amount of SQE to add to the wells. The binding of monoclonal antibodies and anti-SQE serum was dependent upon both the amount of antibody added to the wells and the amount of SQE added to the wells. Antibody concentration curves were hyperbolic in shape, as seen with most other antibodies. Antibody binding first increased with SQE amount and then reached a plateau around 10 nmol of SQE/well. At high SQE amounts (> 75 nmol/well), antibody binding decreased with the amount of SQE added. Using H-3-SQE, the amount of SQE bound to the wells increased linearly, up to 50 nmol of SQE added. Approximately 90% of the added SQE bound to the well. When amounts greater than 100 nmol of SQE were added, the amount of SQE bound to the wells was greatly reduced to approximately 5 - 10% of the added SQE. The assay was highly reproducible both from lot to lot of plates and from experiment to experiment. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD 20910 USA. RP Matyas, GR (reprint author), Walter Reed Army Inst Res, Dept Membrane Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. OI Matyas, Gary/0000-0002-2074-2373 NR 12 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD SEP 15 PY 2002 VL 267 IS 2 BP 119 EP 129 AR PII S0022-1759(02)00180-1 DI 10.1016/S0022-1759(02)00180-1 PG 11 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 590UP UT WOS:000177842300003 PM 12165433 ER PT J AU Bhatt, RT Chen, YL Morscher, GN AF Bhatt, RT Chen, YL Morscher, GN TI Microstructure and tensile properties of BN/SiC coated Hi-Nicalon, and Sylramic SiC fiber preforms SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID DAMAGE ACCUMULATION; MATRIX COMPOSITES; ACOUSTIC-EMISSION; CRACK INITIATION; WOVEN AB Batch to batch and within batch variations, and the influence of fiber architecture on room temperature physical and tensile properties of BN/SiC coated Hi-Nicalon and Sylramic SiC fiber preform specimens were determined. The three fiber architectures studied were plain weave (PW), 5-harness satin (5HS), and 8-harness satin (8HS). Results indicate that the physical properties vary up to 10 percent within a batch, and up to 20 percent between batches of preforms. Load-reload (Hysteresis) and acoustic emission methods were used to analyze damage accumulation occurring during tensile loading. Early acoustic emission activity, before observable hysteretic behavior, indicates that the damage starts with the formation of nonbridged tunnel cracks. These cracks then propagate and intersect the load bearing "0degrees" fibers giving rise to hysteretic behavior. For the Hi-Nicalon preform specimens, the onset of "0degrees" bundle cracking stress and strain appeared to be independent of the fiber architecture. Also, the "0degrees" fiber bundle cracking strain remained nearly the same for the preform specimens of both fiber types. TEM analysis indicates that the CVI BN interface coating is mostly amorphous and contains carbon and oxygen impurities, and the CVI SiC coating is crystalline. No reaction exists between the CVI BN and SiC coating. (C) 2002 Kluwer Academic Publishers. C1 NASA, USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. Ohio Aerosp Inst, Brookpark, OH 44142 USA. Dynacs Engn Co Inc, Brookpark, OH 44142 USA. RP Bhatt, RT (reprint author), NASA, USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 21 TC 7 Z9 8 U1 0 U2 12 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP 15 PY 2002 VL 37 IS 18 BP 3991 EP 3998 DI 10.1023/A:1019692514089 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 581TJ UT WOS:000177309000024 ER PT J AU Romanov, DA Mitin, VV Stroscio, MA AF Romanov, DA Mitin, VV Stroscio, MA TI Polar interface vibrations in GaN/AlN quantum dots: Essential effects of crystal anisotropy SO PHYSICAL REVIEW B LA English DT Article ID HETEROSTRUCTURES; SCATTERING; PHONONS; MODES AB The inherent anisotropy of crystal lattices of the nitride semiconductor compounds is found to essentially determine the character of surface polar vibrations of a GaN quantum dot in AlN matrix. The interface phonons are analyzed within the framework of the anisotropic macroscopic dielectric continuum model. Analytical solutions are obtained for surface modes on a quantum dot of oblate spheroidal form. These modes can exist in continuous frequency regions, in contrast to quantized frequencies that are characteristic for isotropic case. The period of spatial oscillations in these modes varies substantially over the dot surface, so that the oscillations can have condensation points at the dot poles. Along with truly localized surface states, there are two other types of phonon modes. First, runaway modes, which freely leave the dot surface through escape roots in equatorial regions. Second, quasistationary (leaky) states, in which the areas of spatial oscillations are separated from the escape root regions by the areas of exponential behavior. The leaky states can provide effective energy relaxation of the confined electrons. C1 Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. USA, Res Off, Raleigh, NC 27695 USA. RP Romanov, DA (reprint author), Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. NR 12 TC 24 Z9 24 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 2002 VL 66 IS 11 AR 115321 DI 10.1103/PhysRevB.66.115321 PG 6 WC Physics, Condensed Matter SC Physics GA 601RG UT WOS:000178461000067 ER PT J AU Kuklo, TR Lenke, LG Graham, EJ Won, DS Sweet, FA Blanke, KM Bridwell, KH AF Kuklo, TR Lenke, LG Graham, EJ Won, DS Sweet, FA Blanke, KM Bridwell, KH TI Correlation of radiographic, clinical, and patient assessment of shoulder balance following fusion versus nonfusion of the proximal thoracic curve in adolescent idiopathic scoliosis SO SPINE LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Scoliosis-Research-Society CY SEP 19-22, 2001 CL CLEVELAND, OHIO SP Scoliosis Res Soc DE adolescent idiopathic scoliosis; proximal thoracic curve; spontaneous correction; patient outcome; clavicle angle ID COTREL-DUBOUSSET INSTRUMENTATION; SURGICAL-TREATMENT; SPINAL-FUSION; PATTERN; ANTERIOR; RECOGNITION; SELECTION AB Study Design. Retrospective clinical, radiographic, and patient outcome review of surgically treated adolescent idiopathic scoliosis. Objectives. To correlate radiographic and clinical features of shoulder balance and the proximal thoracic curve with patient satisfaction outcomes at a maximum 2-year follow-up. Summary of Background Data. Traditionally, radiographic features of a structural proximal thoracic curve have been T1 tilt, proximal thoracic Cobb angle, and proximal thoracic side-bending Cobb; however, these do not always correlated with clinical shoulder balance. Methods. A total of 112 patients (single surgeon) with adolescent idiopathic scoliosis and a proximal thoracic curve greater than or equal to20degrees (average 32degrees, range 20-78degrees) were evaluated in terms of shoulder balance and curve flexibilty/correction. Four groups were analyzed: Group 1, posterior spinal fusion to T2 (proximal thoracic curve included, n=24); Group 2, posterior spinal fusion to T3 (proximal thoracic curve partially included, n=23); Group 3, posterior spinal fusion to T4 or T5 (proximal thoracic curve not included, n=21); and Group 4, anterior spinal fusion to T4 or below (proximal thoracic not included, n=44). Proximal thoracic, main thoracic, and thoracolumbar-lumbar upright coronal, side-bending, and sagittal Cobb measurements were assessed before surgery, 1 week after surgery, and at a minimum 2-year postoperative follow-up (average 3.8 years, range 2.0-7.6 years). In additions to T1 tilt, clavic angle (intersection of a horizontal line and the tangential line connecting the highest two points of each clavicle), coracoid height difference, trapezius length (horizontal distance of the T2 pedicle to second rib-clavicle intersection), first rib-clavicle height difference (vertical distance of first rib apex to superior clavicle), and proximal thoracic, main thoracic, and thoracolumbar-lumbar apical vertical translation were determined. Shoulder asymmetry as measured by the radiographic soft tissue shadow was graded as balanced (<1 cm), slight (1-2 cm), moderate (2-3 cm), or significant (>3 cm). A postoperative patient questionnaire addressed shoulder balance and overall appearance at most recent follow-up. Result. The four groups were found to statistically equivalent in terms of preoperative proximal thoracic curve (P=0.4146), proximal thoracic side-bending Cobb (P=0.2199), main thoracic curve (P=0.6999), and main thoracic side-bending curves (P=0.7307). Radiographic: Preoperative proximal thoracic measurements correlating with postoperative shoulder balance (P<0.05) included the clavicle angle (three of four groups with a trend toward statistical significance in the fourth group, P=0.07) and coracoid height (two or four groups). No other measurement, including T1 tilt and proximal thoracic side-bending Cobb, correlated in more than one group. Proximal thoracic curve correction was greatest in Group 1 (posterior spinal fusion to T2; average 12&DEG;) and Group 4 (anterior spinal fusion to T4 or below; average 12&DEG;). Clinical: Shoulder balance improved in all four groups (range 0.38-1.00 grades). There was no difference in shoulder balance between groups (P=0.2723). Patient assessment: All four groups also reported improvement in self perceived shoulder balance (63% up to one grade, 37% over two-grade improvement), whereas no patient reported worsening of shoulder balance. There was no significant difference in patient outcomes between the four groups (P=0.3654). Conclusion. The clavicle angle, not T1 tilt, upright proximal thoracic, or side-bending proximal thoracic Cobb, provided the best preoperative radiographic prediction of postoperative shoulder balance. In each of the four groups, postoperative shoulder balance and clinical appearance also improved and correlated with patient postoperative assessments. C1 Univ Washington, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. RP Lenke, LG (reprint author), Univ Washington, Sch Med, Dept Orthopaed Surg, 1 Barnes Jewish Hosp Plaza,Suite 11300 W Pavil, St Louis, MO 63110 USA. NR 24 TC 69 Z9 93 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2002 VL 27 IS 18 BP 2013 EP 2020 DI 10.1097/01.BRS.0000024162.02138.F9 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 594ZJ UT WOS:000178082100008 PM 12634561 ER PT J AU Wittke, V Robb, TE Thu, HM Nisalak, A Nimmannitya, S Kalayanrooj, S Vaughn, DW Endy, TP Holmes, EC Aaskov, JG AF Wittke, V Robb, TE Thu, HM Nisalak, A Nimmannitya, S Kalayanrooj, S Vaughn, DW Endy, TP Holmes, EC Aaskov, JG TI Extinction and rapid emergence of strains of dengue 3 virus during an interepidernic period SO VIROLOGY LA English DT Article DE dengue virus; evolution; Thailand ID MOLECULAR EVOLUTION; TYPE-2 VIRUS; RNA VIRUS; HEMORRHAGIC-FEVER; AEDES-AEGYPTI; AMINO-ACID; PROTEIN; NEUROVIRULENCE; EPIDEMIOLOGY; GLYCOPROTEIN AB Strains of dengue 3 (DEN-3) virus circulating in Thailand prior to 1992 appear to have disappeared from that location and to have been replaced by two new lineages which have evolved locally, rather than being introduced. Similar DEN-3 virus extinctions may have occurred previously in Thailand in 1962 and 1973. Although no causal relationship could be shown, this strain replacement event was accompanied by DEN-3 replacing DEN-2 as the serotype recovered most frequently from patients in Thailand. Although this implies a change in selection pressure, we found no evidence for positive natural selection at the level of either the E protein or the E protein gene. Further, the extinction of the pre-1992 strains and the appearance of the new lineages occurred during an interepidemic period, suggesting that a genetic bottleneck, rather than selection, might have been important in the emergence of these two new strains of virus. The pre-1992 DEN-3 virus lineage could still be found in 1998, to the west, in Myanmar. The ratio of nonsynonymous-to-synonymous nucleotide changes within a DEN-3 virus population from a single patient was less than the ratio among the consensus sequences of DEN-3 viruses from different patients, suggesting that many of the nonsynonymous nucleotide changes which occurred naturally in the E protein were deleterious and removed by purifying selection, (C) 2002 Elsevier Science (USA). C1 Queensland Univ Technol, Sch Life Sci, Brisbane, Qld 4001, Australia. Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Univ Oxford, Dept Zool, Oxford OX1 3PS, England. RP Aaskov, JG (reprint author), Queensland Univ Technol, Sch Life Sci, GPO Box 2434, Brisbane, Qld 4001, Australia. OI Holmes, Edward/0000-0001-9596-3552 NR 38 TC 108 Z9 112 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 15 PY 2002 VL 301 IS 1 BP 148 EP 156 DI 10.1006/viro.2002.1549 PG 9 WC Virology SC Virology GA 598BG UT WOS:000178254800016 PM 12359455 ER PT J AU Botos, I O'Keefe, BR Shenoy, SR Cartner, LK Ratner, DM Seeberger, PH Boyd, MR Wlodawer, A AF Botos, I O'Keefe, BR Shenoy, SR Cartner, LK Ratner, DM Seeberger, PH Boyd, MR Wlodawer, A TI Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN GP120; INACTIVATING PROTEIN; BINDING; TYPE-1; CRYSTAL; CYANOBACTERIUM; GLYCOSYLATION; AFFINITY; SYSTEM AB The development of anti-human immunodeficiency virus (HIV) microbicides for either topical or ex vivo use is of considerable interest, mainly due to the difficulties in creating a vaccine that would be active against multiple clades of HIV. Cyanovirin-N (CV-N), an 11-kDa protein from the cyanobacterium (blue-green algae) Nostoc ellipsosporum with potent virucidal activity, was identified in the search for such antiviral agents. The binding of CV-N to the heavily glycosylated HIV envelope protein gp120 is carbohydrate-dependent. Since previous CV-N-dimannose structures could not fully explain CVN-oligomannose binding, we determined the crystal structures of recombinant CV-N complexed to Man-9 and a synthetic hexamannoside, at 2.5- and 2.4-Angstrom resolution, respectively. CV-N is a three-dimensional domain-swapped dimer in the crystal structures with two primary sites near the hinge region and two secondary sites on the opposite ends of the dimer. The binding interface is constituted of three stacked alpha1-->2-linked mannose rings for Man-9 and two stacked mannose rings for hexamannoside with the rest of the saccharide molecules pointing to the solution. These structures show unequivocally the binding geometry of high mannose sugars to CV-N, permitting a better understanding of carbohydrate binding to this potential new lead for the design of drugs against AIDS. C1 NCI, Macromol Crystallog Lab, NIH, Frederick, MD 21702 USA. NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA. SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA. MIT, Dept Chem, Cambridge, MA 02139 USA. Univ S Alabama, Coll Med, USA, Canc Res Inst, Mobile, AL 36688 USA. RP Wlodawer, A (reprint author), NCI, Macromol Crystallog Lab, NIH, MCL Bldg 536,Rm 5, Frederick, MD 21702 USA. FU NCI NIH HHS [N01 CO 12400] NR 42 TC 125 Z9 130 U1 1 U2 12 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 13 PY 2002 VL 277 IS 37 BP 34336 EP 34342 DI 10.1074/jbc.M205909200 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 592WD UT WOS:000177959100105 PM 12110688 ER PT J AU Ligon, DA Wetmore, AE Gillespie, PS AF Ligon, DA Wetmore, AE Gillespie, PS TI Simulation of the passive infrared spectral signatures of bioaerosol and natural fog clouds immersed in the background atmosphere SO OPTICS EXPRESS LA English DT Article ID OPTICAL-PROPERTIES; VAPOR-DETECTION; MU-M; BAND AB At first glance, an examination of the bulk refractive indices for the 8-12 mum waveband of various bioaerosols suggests differentiation with respect to common background aerosols based upon the spectral characteristics of the absorption. The question of whether there is a spectral signature of bioaerosol clouds when those clouds are immersed in a typical atmosphere, including the boundary layer background aerosols, has been addressed in a simulation using the Weather and Atmospheric Visualization Effects for Simulation (WAVES) suite of codes. Using measured values of the refractive index for common bacterial spores, and their typical size distributions, the single-scattering, ensemble-averaged optical properties such as extinction/absorption coefficients, albedo, and the scattering phase function was computed for bioaerosol clouds at a resolution of 1 cm(-1). WAVES was then used to calculate the radiative transfer for a finite sized cloud immersed in background. Results of this simulation indicate that, for a passive remote sensing measurement, it is unlikely that bioaerosol clouds can be identified from the spectral signature alone. (C) 2002 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Ligon, DA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dligon@arl.army.mil NR 18 TC 7 Z9 7 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 9 PY 2002 VL 10 IS 18 BP 909 EP 919 DI 10.1364/OE.10.000909 PG 11 WC Optics SC Optics GA 591PY UT WOS:000177890500001 PM 19451945 ER PT J AU Dowling, WE Kim, B Mason, CJ Wasunna, KM Alam, U Elson, L Birx, DL Robb, ML McCutchan, FE Carr, JK AF Dowling, WE Kim, B Mason, CJ Wasunna, KM Alam, U Elson, L Birx, DL Robb, ML McCutchan, FE Carr, JK TI Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants SO AIDS LA English DT Article DE Kenya; full-genome sequences; HIV-1 subtypes; recombination; A2 sub-subtype ID IMMUNODEFICIENCY-VIRUS TYPE-1; HETERODUPLEX MOBILITY ASSAY; GENETIC DIVERSITY; INTERSUBTYPE RECOMBINANTS; REVERSE-TRANSCRIPTASE; PHYLOGENETIC ANALYSIS; V3 REGION; STRAINS; IDENTIFICATION; DNA AB Objective: To further define the genetic diversity of HIV-1 in Kenya using approaches that clearly distinguish subtypes from inter-subtype recombinants. Design: Near full genome sequencing and analysis were used, including sensitive new tools for detection and mapping of recombinants. Methods: Purified peripheral blood mononuclear cell DNA from 41 HIV-1 positive blood donations collected from six hospitals across southern Kenya was used to amplify near full-length genomes by nested PCR. These were sequenced on an ABI 3100 automated sequencer and analyzed phylogenetically. Results: Among 41 near full-length genomes, 25 were non-recombinant (61%) and 16 were recombinant (39%). Of the 25 pure subtypes, 23 were subtype A, one was subtype C and one was subtype D. Most recombinants consisted of subtype A and either subtype C or subtype D; a few contained A2, a recently identified sub-subtype. Two A2/D recombinants had identical breakpoints and may represent a circulating recombinant form. A third A2/D recombinant had the same structure as a previously described Korean isolate, and these may constitute a second A2-containing circulating recombinant form. Conclusions: In Kenya, 93% of HIV-1 genomes were subtype A or A-containing recombinant strains. Almost 40% of all strains were recombinant. Vaccine candidates tested in Kenya should be based on subtype A strains, but the methods used for evaluation of breakthrough infections during future vaccine trials should be capable of identifying non-A subtypes, the A2 sub-subtype, and recombinants. (C) 2002 Lippincott Williams Wilkins. C1 Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. Henry M Jackson Fdn, Rockville, MD USA. USA, Med Res Unit, Nairobi, Kenya. Kenya Govt Med Res Ctr, Nairobi, Kenya. RP Dowling, WE (reprint author), Walter Reed Army Inst Res, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. OI MASON, CARL/0000-0002-3676-2811 NR 49 TC 82 Z9 87 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD SEP 6 PY 2002 VL 16 IS 13 BP 1809 EP 1820 DI 10.1097/00002030-200209060-00015 PG 12 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 594AZ UT WOS:000178027800014 PM 12218394 ER PT J AU Josse, D Ebel, C Stroebel, D Fontaine, A Borges, F Echalier, A Baud, D Renault, F le Maire, M Chabrieres, E Masson, P AF Josse, D Ebel, C Stroebel, D Fontaine, A Borges, F Echalier, A Baud, D Renault, F le Maire, M Chabrieres, E Masson, P TI Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1) SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; THIOL CROSS-LINKING; A-I; MEMBRANE-PROTEINS; ESCHERICHIA-COLI; HUMAN-PLASMA; PURIFICATION; DIMERIZATION; BINDING AB Human plasma paraoxonase (HuPON1) is a high density lipoprotein (HDL)-bound enzyme exhibiting anti-atherogenic properties. The molecular basis for the binding specificity of HuPON1 to HDL has not been established. Isolation of HuPON1 from HDL requires the use of detergents. We have determined the activity, dispersity, and oligomeric states of HuPON1 in solutions containing mild detergents using nondenaturing electrophoresis, size exclusion chromatography, and crosslinking. HuPON1 was active whatever its oligomeric state. In nonmicellar solutions, HuPON1 was polydisperse. In contrast, HuPON1 exhibited apparent homogeneity in micellar solutions, except with CHAPS. The enzyme apparent hydrodynamic radius varied with the type of detergent and protein concentration. In C12E8 micellar solutions, from sedimentation velocity, equilibrium analytical ultracentrifugation, and radioactive detergent binding, HuPON1 was described as monomers and dimers in equilibrium. A decrease of the detergent concentration shifted this equilibrium toward the formation of dimers. About 100 detergent molecules were associated per monomer and dimer. The assembly of amphiphilic molecules, phospholipids in vivo, in sufficiently large aggregates could be a prerequisite for anchoring of HuPON1 and then allowing stabilization of the enzyme activity. Changes of HDL size and shape could strongly affect the binding affinity and stability of HuPON1 and result in reduced antioxidative capacity of the lipoprotein. C1 Ctr Rech Serv Sante Armees, Unite Enzymol, F-38702 La Tronche, France. UJF, UMR 5075 CNRS, CEA,Lab Biol Mol, Inst Biol Struct JP Ebel, F-38027 Grenoble 01, France. Univ Paris 11, CEA, URA CNRS 2096, SBFM,DBJC, F-91191 Gif Sur Yvette, France. Univ Paris 11, CEA, LRA17V, F-91191 Gif Sur Yvette, France. Univ Nancy 1, LCM3B, F-54506 Vandoeuvre Les Nancy, France. RP Josse, D (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RI Borges, Frederic/A-7012-2012; Masson, Patrick/J-3964-2013; OI Masson, Patrick/0000-0002-7837-3662; Borges, Frederic/0000-0002-6159-5509 NR 55 TC 53 Z9 55 U1 1 U2 6 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 6 PY 2002 VL 277 IS 36 BP 33386 EP 33397 DI 10.1074/jbc.M200108200 PG 12 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 591BC UT WOS:000177859000128 PM 12080042 ER PT J AU Taub, IA Roberts, W LaGambina, S Kustin, K AF Taub, IA Roberts, W LaGambina, S Kustin, K TI Mechanism of dihydrogen formation in the magnesium-water reaction SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID HYDRATED ELECTRON; PRECURSOR; KINETICS; ABSORPTION; SCAVENGERS AB The thermodynamically favored reaction between water and magnesium, Mg + 2H(2)O --> Mg(OH)(2) + H-2, is normally sluggish, but it becomes reasonably rapid when a milled composite of powdered magnesium metal and powdered iron (1 - 10 mol %) is used with sodium chloride solutions. Iron functions as an activator, and chloride functions as a catalyst that depassivates the outermost oxide/hydroxide layer and allows water to penetrate to the activated magnesium surface. Adding solutes such as sodium nitrate, copper(II) chloride, and sodium trichloroacetate to the reaction mixture suppresses the yield of dihydrogen. Manometric and calorimetric studies on the stoichiometry and kinetics of the reaction between Mg(Fe) powders and aqueous solutions demonstrate that short-lived, partially, and fully solvated electrons (e(p)(-) and e(s)(-)) are precursors of dihydrogen and that they and the hydrogen atoms (H-.) formed from them can be scavenged, resulting in suppressed dihydrogen yields. C1 Brandeis Univ, Dept Chem Emeritus, Waltham, MA 02454 USA. USA, Natick Soldier Ctr, Natick, MA 01760 USA. Somerville High Sch, Somerville, MA 02143 USA. RP Kustin, K (reprint author), Brandeis Univ, Dept Chem Emeritus, POB 9110, Waltham, MA 02454 USA. NR 33 TC 22 Z9 23 U1 2 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD SEP 5 PY 2002 VL 106 IS 35 BP 8070 EP 8078 DI 10.1021/jp0143847 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 589KR UT WOS:000177758000011 ER PT J AU Kalns, J Lane, J Delgado, A Scruggs, J Ayala, E Gutierrez, E Warren, D Niemeyer, D Wolf, EG Bowden, RA AF Kalns, J Lane, J Delgado, A Scruggs, J Ayala, E Gutierrez, E Warren, D Niemeyer, D Wolf, EG Bowden, RA TI Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils SO IMMUNOLOGY LETTERS LA English DT Article DE neutrophil adhesion; hyperbaric oxygen; Mac-1; reperfusion injury; human; beta-2-integrin ID LEUKOCYTE B-2 INTEGRINS; REPERFUSION INJURY; TRANSENDOTHELIAL MIGRATION; PULMONARY SEQUESTRATION; MONOCLONAL-ANTIBODIES; ISCHEMIA-REPERFUSION; SKELETAL-MUSCLE; ADHESION; INHIBITION; ANTI-CD11B AB Highly elevated partial pressures of oxygen achievable during hyperbaric oxygenation (HBO) have been shown to reduce leukocyte sequestration following ischemia/reperfusion injury suggesting a clinical role for HBO in treatment of various disease states characterized by transient ischemia. Previous studies have suggested that this effect may be due to inhibition of beta2-integrin function. In this study the effect of HBO on various CD11b/CD18 (Mac-1) mediated neutrophil functions was investigated in healthy human subjects. HBO 3.0 ATA, 23 m reduced adhesion 50% at 2 h with return to pre-HBO levels by 6 h. Homotypic aggregation, a Mac-1 dependent function, under fluid shear following stimulation with f-MLP was reduced from 20+/-2.6 to 3.4+/- 1.0% 2 h after HBO. However, HBO did not inhibit adhesion to IL-1beta stimulated HUVEC. Mac-1 mediated oxidative burst induced by opsonized zymosan was reduced 38.2+/-10.6% (P < 0.05) by HBO. However, oxidative burst induced by PMA or f-MLP was not affected. HBO did not alter the distribution of neutrophils displaying morphologies associated with stimulation (ruffled, bipolar, uropod) over a 24 h period after HBO nor did HBO change the percentages of mature versus immature cells. Taken together these findings demonstrate that HBO specifically inhibits Mac-1 mediated functions. (C) 2002 Elsevier Science B.V. All rights reserved. C1 Brooke Army Med Ctr, Primary Lab Origin, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. Inst Surg Res, Ft Sam Houston, TX 78234 USA. 60th Med Support Squadron, Clin Invest Facil, Travis AFB, CA 94535 USA. Davis Hyperbar Lab, Brooks AFB, TX 78235 USA. RP Kalns, J (reprint author), USAF, Sch Aerosp Med, FEH, 2602 W Gate Rd, Brooks AFB, TX 78235 USA. NR 25 TC 24 Z9 27 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD SEP 2 PY 2002 VL 83 IS 2 BP 125 EP 131 AR PII S0165-2478(02)00068-8 DI 10.1016/S0165-2478(02)00068-8 PG 7 WC Immunology SC Immunology GA 574KB UT WOS:000176887200007 PM 12067761 ER PT J AU Malvar, LJ Cline, GD Burke, DF Rollings, R Sherman, TW Greene, JL AF Malvar, LJ Cline, GD Burke, DF Rollings, R Sherman, TW Greene, JL TI Alkali-silica reaction mitigation: State of the art and recommendations SO ACI MATERIALS JOURNAL LA English DT Article DE alkali-silica reaction; concrete; fly ash; silica fume; slag ID FLY-ASH; EXPANSION; CONCRETE; ADMIXTURES AB Alkali-silica reaction (ASR) mitigation techniques from various states in the United States, and from various countries and international organizations, were assessed and summarized. A set of recommended mitigation procedures was developed that requires not only the use of low-alkali cement, but replacement of part of it by Class F fly ash (or Class N pozzolan) (25 to 40% by weight), or ground granulated blast-furnace slag (GGBFS), Grade 100 or 120 (40 to 50% by weight), or a combination of both. The Class F fly ash (or Class, N pozzolan) should also have a maximum of 1.5% available alkali, a maximum 6% loss on ignition, and a maximum of 8% CaO (lime). A modified ASTM C 1260 using the actual mixture is recommended for ASR testing. In addition to mitigating ASR, these recommendations are expected to: 1) reduced concrete costs; 2) enhance the durability of concrete; 3) increase fly ash and GGBFS recycling; and 4) support the 1997 Kyoto protocol by significantly reducing CO2 production. If 25% of all cement was to be replaced, total savings to the United States economy could be in excess of $1 billion every year. C1 USN, Naval Facil Engn Command, Washington, DC 20350 USA. USA, Corps Engineers, TSMCX, Washington, DC 20310 USA. USAF, Civil Engineer Support Agcy, Washington, DC 20330 USA. RP Malvar, LJ (reprint author), USN, Naval Facil Engn Command, Washington, DC 20350 USA. NR 97 TC 30 Z9 30 U1 1 U2 6 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 USA SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD SEP-OCT PY 2002 VL 99 IS 5 BP 480 EP 489 PG 10 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA 599JX UT WOS:000178332100008 ER PT J AU Fasiska, EJ Pang, Y Dax, FR Yu, KOO Crist, EM Martin, BW Luckowski, S Florence, J AF Fasiska, EJ Pang, Y Dax, FR Yu, KOO Crist, EM Martin, BW Luckowski, S Florence, J TI Titanium armor plate SO ADVANCED MATERIALS & PROCESSES LA English DT Article AB Titanium alloy armor for combat vehicles has been successfully manufactured via plasma arc cold hearth melting (PAM) at a cost significantly lower than possible with current commercial processes. C1 Concurrent Technol Corp, Johnstown, PA USA. RMI Titanium Co, Niles, OH USA. Galt Alloys Inc, Canton, OH USA. USA, Armament Res Dev & Engn Ctr, TACOM, Picatinny Arsenal, NJ USA. USA, TARDEC, Warren, MI USA. RP Fasiska, EJ (reprint author), Concurrent Technol Corp, 425 6th Ave,Reg Enterprise Tower,28th Floor, Pittsburgh, PA 15219 USA. NR 0 TC 3 Z9 3 U1 1 U2 4 PU ASM INTERNATIONAL PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD SEP PY 2002 VL 160 IS 9 BP 35 EP 37 PG 3 WC Materials Science, Multidisciplinary SC Materials Science GA 592JG UT WOS:000177934000005 ER PT J AU Judd, DB Kim, DH AF Judd, DB Kim, DH TI Foot fractures frequently misdiagnosed as ankle sprains SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID POSTERIOR PROCESS; TALUS; INJURIES; DIAGNOSIS AB Most ankle injuries are straightforward ligamentous injuries. However, the clinical presentation of subtle fractures can be similar to that of ankle sprains, and these fractures are frequently missed on initial examination. Fractures of the talar dome may be medial or lateral, and they are usually the result of inversion injuries, although medial injuries may be atraumatic. Lateral talar process fractures are characterized by point tenderness over the lateral process. Posterior talar process fractures are often associated with tenderness to deep palpation anterior to the Achilles tendon over the posterolateral talus, and plantar flexion may exacerbate the pain. These fractures can often be managed nonsurgically with nonweight-bearing status and a short leg cast worn for approximately four weeks. Delays in treatment can result in long-term disability and surgery. Computed tomographic scans or magnetic resonance imaging may be required because these fractures are difficult to detect on plain films. Copyright(C) 2002 American Academy of Family Physicians. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Judd, DB (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 26 TC 24 Z9 24 U1 0 U2 4 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 2002 VL 66 IS 5 BP 785 EP 794 PG 10 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 594FP UT WOS:000178038600006 PM 12322769 ER PT J AU Elgin, EE O'Malley, PG Feuerstein, I Taylor, AJ AF Elgin, EE O'Malley, PG Feuerstein, I Taylor, AJ TI Frequency and severity of "incidentalomas" encountered during electron beam computed tomography for coronary calcium in middle-aged army personnel SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID ARTERY DISEASE; RISK-FACTORS; ASYMPTOMATIC MEN; CALCIFICATION; ASSOCIATION; YOUNG AB We encountered incidental findings during electron beam computed tomographic examinations for coronary calcium in 79 of 1,000 middle-aged men and women (40 to 45 years old). Incidental findings, of which pulmonary findings were most common (29% of cases), were estimated to result in an average cost of $36/patient undergoing electron beam computed tomography. C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Serv Radiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 georgia Ave NW,Bldg 2,Room 4A, Washington, DC 20307 USA. NR 10 TC 22 Z9 22 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD SEP 1 PY 2002 VL 90 IS 5 BP 543 EP + DI 10.1016/S0002-9149(02)02533-X PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 592ET UT WOS:000177924300022 PM 12208421 ER PT J AU Anderson, ML Ramos, F Chung, M AF Anderson, ML Ramos, F Chung, M TI Unusual causes of coccygodynia SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 525 BP S173 EP S173 DI 10.1016/S0002-9270(02)05007-4 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400526 ER PT J AU Anderson, ML Ramos, F AF Anderson, ML Ramos, F TI Chronic appendicitis presenting as Crohns disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 423 BP S139 EP S139 DI 10.1016/S0002-9270(02)04895-5 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400424 ER PT J AU Duncan, MB Smith, MT AF Duncan, MB Smith, MT TI An unusual case of colonic lymphoma presenting as a diminutive colon polyp SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 519 BP S171 EP S171 DI 10.1016/S0002-9270(02)05001-3 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400520 ER PT J AU Hwang, I Calvit, TB Cash, BD Holtzmuller, KC AF Hwang, I Calvit, TB Cash, BD Holtzmuller, KC TI Bell's palsy. A rare complication of interferon therapy for hepatitis C SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Res Inst, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 634 BP S207 EP S208 DI 10.1016/S0002-9270(02)05116-X PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400635 ER PT J AU Hwang, I Choi, JHR Pickhardt, PJ Smith, JH Butler, JA Wong, RKH AF Hwang, I Choi, JHR Pickhardt, PJ Smith, JH Butler, JA Wong, RKH TI Virtual colonoscopy: A multi-centered screening study of military beneficiaries SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Res Inst, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 369 BP S122 EP S122 DI 10.1016/S0002-9270(02)04841-4 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400370 ER PT J AU Jones, DP Rensch, MJ AF Jones, DP Rensch, MJ TI A randomized, crossover comparison of once daily pantoprazole versus omeprazole bid in the suppression of gastric acid in patients with GERD SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Dept Gastroenterol, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 15 BP S5 EP S6 DI 10.1016/S0002-9270(02)04448-9 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400016 ER PT J AU Magnet, AD Fraser, SL Ramos, F AF Magnet, AD Fraser, SL Ramos, F TI Primary sclerosing cholangitis: A novel presentation of Job's syndrome SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 459 BP S152 EP S152 DI 10.1016/S0002-9270(02)04931-6 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400460 ER PT J AU Marten, D Holtzmuller, K Julia, F AF Marten, D Holtzmuller, K Julia, F TI Bacterial infections complicating hepatitis C infected hemodialysis dependent patients treated with interferon alfa SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Serv Gastroenterol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 495 BP S163 EP S164 DI 10.1016/S0002-9270(02)04977-8 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400496 ER PT J AU McNear, ST Fincher, RK Steinberger, BA AF McNear, ST Fincher, RK Steinberger, BA TI Metformin induced cholestatic hepatitis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Dwight D Eisenhower Army Med Ctr, Gastroenterol Serv, Ft Gordon, GA USA. Dwight D Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 311 BP S102 EP S102 DI 10.1016/S0002-9270(02)04783-4 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400312 ER PT J AU Mulhall, BP Wong, RKH AF Mulhall, BP Wong, RKH TI Cost-effectiveness of screening for Barrett's esophagus in all patients presenting for upper endoscopy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Serv Gastroenterol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 741 BP S243 EP S243 DI 10.1016/S0002-9270(02)05224-3 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400742 ER PT J AU Mulhall, BP Osgard, E DuBois, A Kushner, JP AF Mulhall, BP Osgard, E DuBois, A Kushner, JP TI The use of a nutritional supplement as an antimicrobial in Helicobacter pylori eradication SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. Tripler Army Med Ctr, Serv Gastroenterol, Honolulu, HI 96859 USA. Uniformed Serv Univ Hlth Sci, Div Gastrointestinal & Liver Studies, Bethesda, MD 20814 USA. Madigan Army Med Ctr, Serv Gastroenterol, Tacoma, WA 98431 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 161 BP S53 EP S54 DI 10.1016/S0002-9270(02)04633-6 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400162 ER PT J AU Napierkowski, JJ Sachar, DS Cumings, MD Wong, RKH AF Napierkowski, JJ Sachar, DS Cumings, MD Wong, RKH TI Cytomegalovirus (CMV) infection presenting as a polypoid colonic mass SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Div Gastroenterol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2002 VL 97 IS 9 SU S MA 485 BP S160 EP S161 DI 10.1016/S0002-9270(02)04967-5 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 597PR UT WOS:000178230400486 ER PT J AU Hoge, CW Lesikar, SE Guevara, R Lange, J Brundage, JF Engel, CC Messer, SC Orman, DT AF Hoge, CW Lesikar, SE Guevara, R Lange, J Brundage, JF Engel, CC Messer, SC Orman, DT TI Mental disorders among US military personnel in the 1990s: Association with high levels of health care utilization and early military attrition SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID UNITED-STATES; PSYCHIATRIC-DISORDERS; ADDICTIVE-DISORDERS; SOCIAL MORBIDITY; DEPRESSION; COMMUNITY; SERVICES; PROJECTIONS; DISABILITY; OUTCOMES AB Objective: Epidemiological studies have shown that mental disorders are associated with reduced health-related quality of life, high levels of health care utilization, and work absenteeism. However, measurement of the burden of mental disorders by using population-based methods in large working populations such as the U.S. military, has been limited. Method: Analysis of hospitalizations among all active-duty military personnel (16.4 million person-years) from 1990 to 1999 and ambulatory visits from 1996 to 1999 was conducted by using the Defense Medical Surveillance System. Rates of hospitalization, ambulatory visits, and attrition from military service were compared for persons with mental disorder diagnoses and those with diagnoses in 15 other ICD-9 disease categories. Results: Mental disorders was the leading category of discharge diagnoses among men and the second leading category among women; 13% of all hospitalizations and 23% of all inpatient bed days were attributed to mental disorders. Six percent of the military population received ambulatory services for mental disorders annually in 1998 and 1999. Among a 1-year cohort of personnel, 47% of those hospitalized for the first time for a mental disorder left military service within 6 months. This attrition rate was significantly different from the rate of only 12% after hospitalization for any of the 15 other disease categories (range=11%-18%) (relative risk=4.04, 95% confidence interval=3.91-4.17). The difference remained significant after controlling for effects of age, gender, and duration of service. Conclusions: Mental disorders appear to represent the most important source of medical and occupational morbidity among active-duty U.S. military personnel. These findings provide new population-based evidence that mental disorders are common, disabling, and costly to society. C1 Walter Reed Army Inst Res, Dept Psychiat & Behav Sci, Div Neuropsychiat, Med Res & Mat Command, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Psychiat, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Deployment Hlth Clin Ctr, Silver Spring, MD 20910 USA. USA, Ctr Hlth Promot & Prevent Med, Med Surveillance Act, Washington, DC 20310 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. USA Med Command, Hlth Policy & Sewrv Directorate, Ft Sam Houston, TX 78234 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Dept Psychiat & Behav Sci, Div Neuropsychiat, Med Res & Mat Command, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 36 TC 150 Z9 158 U1 2 U2 9 PU AMER PSYCHIATRIC PRESS, INC PI WASHINGTON PA 1400 K ST, N W, STE 1101, WASHINGTON, DC 20005 USA SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD SEP PY 2002 VL 159 IS 9 BP 1576 EP 1583 DI 10.1176/appi.ajp.159.9.1576 PG 8 WC Psychiatry SC Psychiatry GA 591EQ UT WOS:000177867100018 PM 12202280 ER PT J AU Bui-Mansfield, LT Taylor, DC Uhorchak, JM Tenuta, JJ AF Bui-Mansfield, LT Taylor, DC Uhorchak, JM Tenuta, JJ TI Humeral avulsions of the glenohumeral ligament: Imaging features and a review of the literature SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Roentgen-Ray-Society CY APR-MAY -, 2002 CL ATLANTA, GEORGIA SP Amer Roentgen Ray Soc ID ANTERIOR SHOULDER INSTABILITY; LESION; DISLOCATION; BANKART; JOINT AB OBJECTIVE. We describe the radiologic findings of the humeral avulsion of the glenohumeral ligament (HAGL lesion) and its commonly associated injuries. MATERIALS AND METHODS. A retrospective review of six cases of HAGL lesion diagnosed at our institution from October 1996 to February 2001 was performed. We reviewed the radiology reports, radiologic examinations, medical records, and operative notes. All patients had undergone radiography, and four patients had undergone MR imaging of the shoulder before diagnostic arthroscopy. RESULTS. All the patients were men who ranged in age from 19 to 41 years (mean, 26 years). Four patients (67%) had an anterior shoulder dislocation. Three of the HAGL lesions (50%) were detected on radiologic examinations, either by radiography or MR imaging. One patient had a bony HAGL. All patients had associated injuries. The most common associated abnormalities were osteochondral injury of the humeral head (n = 3), rotator cuff tear (n = 3), Bankart lesion (n = 3), Hill-Sachs lesion (n = 2), avulsion of the middle glenohumeral ligament (n 1), partial tear of the biceps brachii tendon (n = 1), and comminuted fracture of the clavicle (n 1). CONCLUSION. With an incidence of 7.5% and 9.4% in two large series of patients, the HAGL lesion is an important cause of anterior instability of the glenohumeral joint. The majority (68%) of patients with an HAGL lesion have associated injuries. C1 Keller Army Community Hosp, Dept Radiol, W Point, NY 10996 USA. Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Div Radiol Sci, Winston Salem, NC 27157 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. Keller Army Community Hosp, Orthopaed Surg Serv, W Point, NY 10996 USA. RP Bui-Mansfield, LT (reprint author), Keller Army Community Hosp, Dept Radiol, 900 Washington Rd, W Point, NY 10996 USA. NR 13 TC 49 Z9 50 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2002 VL 179 IS 3 AR UNSP 0361-803X/02/1793-649 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586FU UT WOS:000177574600018 PM 12185037 ER PT J AU Bui-Mansfield, LT Myers, CP Fellows, D Mesaros, G AF Bui-Mansfield, LT Myers, CP Fellows, D Mesaros, G TI Bilateral temporal fossa hemangiomas SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID SOFT-TISSUE HEMANGIOMAS C1 Keller Army Community Hosp, Dept Radiol, W Point, NY 10996 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Winston Salem, NC 27157 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Keller Army Community Hosp, Dept Surg, W Point, NY 10996 USA. RP Bui-Mansfield, LT (reprint author), Keller Army Community Hosp, Dept Radiol, 900 Washington Rd, W Point, NY 10996 USA. NR 4 TC 1 Z9 1 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2002 VL 179 IS 3 AR UNSP 0361-803X/02/1793-790 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586FU UT WOS:000177574600043 PM 12185065 ER PT J AU Pickhardt, PJ Rohrmann, CA Cossentino, MJ AF Pickhardt, PJ Rohrmann, CA Cossentino, MJ TI Stomal Metastases complicating percutaneous endoscopic gastrostomy: CT findings and the argument for radiologic tube placement SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID CANCER METASTASIS; SITE; HEAD AB OBJECTIVE. This article describes the CT appearance of metastatic implantation at the percutaneous endoscopic gastrostomy (PEG) tract in patients with malignancy of the upper aerodigestive tract. Cumulative data from previous case reports are also considered for insight into causes of metastasis and the implications for gastrostomy placement in these patients. CONCLUSION. CT showed lobulated soft tissue involving the entire abdominal wall PEG tract in all proven cases. CT is an effective method for evaluation because the tumor burden lies predominately in the abdominal wall and not at the entry or exit site. The stomal implant is often the only site of metastatic disease at presentation. In general, CT findings of mildly increased soft tissue along the PEG tract are nonspecific, but a lobulated mass is highly suspicious for tumor implantation, especially if the one-sided thickness exceeds I cm. The preponderance of evidence from the existing literature points to direct tumor implantation during endoscopic placement as the likely cause (rather than hematogenous spread). This conclusion would support the alternative of radiologic tube placement in these patients. C1 Natl Naval Med Res Inst, Dept Radiol, Bethesda, MD 20889 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. Univ Washington, Dept Radiol, Seattle, WA 98195 USA. Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. RP Pickhardt, PJ (reprint author), Natl Naval Med Res Inst, Dept Radiol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 14 TC 21 Z9 21 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2002 VL 179 IS 3 AR UNSP 0361-803X/02/1793-735 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586FU UT WOS:000177574600034 PM 12185055 ER PT J AU Tis, JE Klemme, WR Kirk, KL Murphy, KP Cunningham, B AF Tis, JE Klemme, WR Kirk, KL Murphy, KP Cunningham, B TI Braided hamstring tendons for reconstruction of the anterior cruciate ligament - A biomechanical analysis SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article ID PATELLAR TENDON; GRAFTS; SEMITENDINOSUS AB Background: In an effort to improve the strength and stiffness of anterior cruciate ligament grafts, several authors have advocated alterations of graft structure and orientation, including braiding the tendons in hamstring tendon grafts. Hypothesis: Braiding hamstring tendons does not increase graft strength and stiffness. Study Design: Controlled laboratory study. Methods: Sixteen hamstring tendon and 21 bone-patellar tendon-bone grafts were harvested from 12 cadavers and divided into three groups: 1) braided four-strand hamstring tendon, 2) unbraided four-strand hamstring tendon, and 3) bone-patellar tendon-bone. All grafts were placed under a 50-N preload on a servohydraulic testing device and were tensioned to failure. Results: The strength and stiffness of the tested specimens averaged 427 +/- 36 N and 76 +/- 10 N/mm, respectively, for braided specimens, 532 +/- 44 N and 139 +/- 18 N/mm for unbraided specimens, and 574 +/- 46 N and 158 +/- 15 N/mm for patellar tendon specimens. There was a 20% decrement in hamstring tendon graft tensile strength and a 45% decrease in stiffness after braiding because of the suboptimal multidirectional orientation of individual tendons within the braided grafts. Conclusions: In vitro braided hamstring tendon grafts demonstrated mechanically inferior strength and stiffness characteristics compared with unbraided hamstring tendon grafts and patellar tendon grafts. Clinical Relevance: Braiding of hamstring tendon grafts provides no mechanical advantage in anterior cruciate ligament reconstruction. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Union Mem Hosp, Orthopaed Biomech Lab, Baltimore, MD USA. RP Klemme, WR (reprint author), USA, 336 Bon Air Ctr 388, Greenbrae, CA 94904 USA. NR 19 TC 9 Z9 9 U1 0 U2 0 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP-OCT PY 2002 VL 30 IS 5 BP 684 EP 688 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 596RV UT WOS:000178180000009 PM 12239002 ER PT J AU Strickman, D Kittayapong, P AF Strickman, D Kittayapong, P TI Dengue and its vectors in Thailand: Introduction to the study and seasonal distribution of Aedes larvae SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; AEGYPTI DIPTERA; PUERTO-RICO; HUMAN BLOOD; JAPANESE ENCEPHALITIS; HEMORRHAGIC-FEVER; FIELD-EVALUATION; WATER JARS; CULICIDAE; MOSQUITOS AB A study was conducted from 1989 to 1994 that included surveillance for dengue and its mosquito vectors in 3 villages and 2 schools in Chachoengsao Province. 100 km east of Bangkok, Thailand. The study is introduced. and results of larval surveys for Aedes mosquitoes (predominantly Aedes aegypti (L.)). With 94 86, and 90% of positive containers infested by this species in the hot. wet, and cool seasons. respectively). are described. These surveys Were conducted in 1990-1991 during each of the 3 principal seasons: hot (February-April), rainy (May-October). and cool (November-January). Indoor maximum and minimum temperatures were consistently greater than outdoor temperatures. The differences between maximum and minimum temperatures both indoors and outdoors varied seasonally, with the greatest differences in the cool season and the least differences in the rainy season. The most rain fell in September and October and the least rain in December, January, and February. The number of Aedes larvae in each container was categorized (no larvae. 1-9 larvae, 10-50 larvae, > 50 larvae) by dipping With a fishnet or by visual examination (for drinking water). A larval index Was calculated for each house and school by summing the estimations from each container. These indexes showed that one village had more larvae in every season (mean larval index per house = 117) than the other 2 villages (larval indexes of 86 and 70). The larval index of each house was mapped for each season, and the distribution was spatially analyzed by producing kriged estimates of interpolated data. These analyses showed that larvae were significantly concentrated in particular areas of the villages, especially during the wet season. Even When larvae were least abundant. every part of each village had at least some larvae. The results of the study imply that dengue vector control programs in Southeast Asian villages could increase their efficiency by applying their most energetic efforts on schools and areas with the greatest abundance of larvae, as measured by calculation of larval indexes. C1 Walter Reed Army Inst Res, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Mahidol Univ, Ctr Vectors & Vector Borne Dis, Bangkok, Thailand. Mahidol Univ, Fac Sci, Dept Biol, Bangkok, Thailand. RP Strickman, D (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 52 TC 40 Z9 42 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2002 VL 67 IS 3 BP 247 EP 259 PG 13 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 604QW UT WOS:000178633400007 PM 12408663 ER PT J AU Waibel, KH Regis, DP Uzel, G Rosenzweig, SD Holland, SM AF Waibel, KH Regis, DP Uzel, G Rosenzweig, SD Holland, SM TI Fever and leg pain in a 42-month-old SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID INTERFERON-GAMMA-RECEPTOR; MYCOBACTERIUM-AVIUM COMPLEX; SEVERE COMBINED IMMUNODEFICIENCY; INFECTION; SUSCEPTIBILITY; MUTATION; DISEASE; DEFICIENCY; MANAGEMENT; CHILDHOOD C1 NIH, Host Def Lab, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Holland, SM (reprint author), NIH, Host Def Lab, Bldg 10,Room 11N103,10 Ctr Dr,MSC 1886, Bethesda, MD 20892 USA. NR 31 TC 11 Z9 11 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD SEP PY 2002 VL 89 IS 3 BP 239 EP 243 PG 5 WC Allergy; Immunology SC Allergy; Immunology GA 595MH UT WOS:000178113000004 PM 12269642 ER PT J AU Grabenstein, JD AF Grabenstein, JD TI Vaccines: Worth paying for the value returned SO ANNALS OF PHARMACOTHERAPY LA English DT Editorial Material ID COST-EFFECTIVENESS; VACCINATION C1 USA, Med Command, Falls Church, VA 22041 USA. RP Grabenstein, JD (reprint author), USA, Med Command, 5111 Leesburg Pike, Falls Church, VA 22041 USA. NR 23 TC 0 Z9 0 U1 0 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD SEP PY 2002 VL 36 IS 9 BP 1471 EP 1472 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 587UA UT WOS:000177660600024 PM 12229878 ER PT J AU Cohen, DJ AF Cohen, DJ TI Validation of a bone analog model for studies of sternal closure - Invited commentary SO ANNALS OF THORACIC SURGERY LA English DT Editorial Material C1 Brooke Army Med Ctr, Med Corps, Cardiothorac Surg Serv, MCHE SDC, Ft Sam Houston, TX 78234 USA. RP Cohen, DJ (reprint author), Brooke Army Med Ctr, Med Corps, Cardiothorac Surg Serv, MCHE SDC, 3851 Roger Brooke Dr,Bldg 3600, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD SEP PY 2002 VL 74 IS 3 BP 745 EP 745 DI 10.1016/S0003-4975(02)03905-X PG 1 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA 591MH UT WOS:000177883900022 ER PT J AU Caravalho, J O'Donnell, SD Feurstein, IM O'Malley, PG Gillespie, DL Goff, JM Sherner, J Van Petten, M Taylor, AJ AF Caravalho, J O'Donnell, SD Feurstein, IM O'Malley, PG Gillespie, DL Goff, JM Sherner, J Van Petten, M Taylor, AJ TI Preoperative risk stratification using electron beam computed tomography in elective vascular surgery: Relationship to clinical risk prediction and postoperative complications SO ANNALS OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 50th Annual Scientific Session of the American College of Cardiology CY MAR 18-20, 2001 CL ORLANDO, FLORIDA SP Amer Coll Cardiol ID CORONARY-ARTERY DISEASE; CARDIAC RISK; NONCARDIAC SURGERY; BYPASS-SURGERY; CALCIUM; SEVERITY; IDENTIFICATION; CALCIFICATION; MORTALITY; MORBIDITY AB We studied the utility of electron beam computed tomography as a screening test for the cardiovascular risk of elective vascular surgery. In 45 patients undergoing principally carotid and aortic surgical procedures, coronary artery calcification was prevalent and severe, and related to the clinically predicted cardiovascular risk of the procedure. However, only the clinically predicted surgical risk, and not coronary artery calcification, was related to the incidence of perioperative cardiovascular complications. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Vasc Surg Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Bldg 2,Room 4A, Washington, DC 20307 USA. OI Gillespie, David/0000-0002-4378-9465 NR 24 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0890-5096 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD SEP PY 2002 VL 16 IS 5 BP 639 EP 643 DI 10.1007/s10016-001-0213-6 PG 5 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 608WZ UT WOS:000178871800020 PM 12219253 ER PT J AU Baum, SE Crawford, SA McElmeel, ML Whitney, CG Jorgensen, JH AF Baum, SE Crawford, SA McElmeel, ML Whitney, CG Jorgensen, JH TI Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent north American isolates of Streptococcus pneumoniae SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID UNITED-STATES; RESISTANCE; INHIBITORS; MANAGEMENT AB The activity of A-ZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 mug/ml and 0.5 and 1 mug/ml, respectively, for the two isolate groups. These MICs were within 1 log(2) dilution of those of linezolid. C1 Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA. Brooke Army Med Ctr, Infect Dis Serv, San Antonio, TX USA. Ctr Dis Control & Prevent, Div Bacterial & Mycot Dis, Natl Ctr Infect Dis, Atlanta, GA USA. RP Jorgensen, JH (reprint author), Univ Texas, Hlth Sci Ctr, Dept Pathol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. NR 13 TC 3 Z9 4 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2002 VL 46 IS 9 BP 3094 EP 3095 DI 10.1128/AAC.46.9.3094-3095.2002 PG 2 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 585FQ UT WOS:000177515000060 PM 12183281 ER PT J AU Boutou, V Favre, C Hill, SC Pan, YL Chang, RK Wolf, JP AF Boutou, V Favre, C Hill, SC Pan, YL Chang, RK Wolf, JP TI Backward enhanced emission from multiphoton processes in aerosols SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID LASER-INDUCED BREAKDOWN; URBAN AEROSOLS; WATER; FLUORESCENCE; AIR; SCATTERING; PULSES; LIDAR; MICROPARTICLES; MICROCAVITIES AB We have investigated, both theoretically and experimentally, multiphoton-induced processes in aerosol particles using femtosecond laser pulses. More specifically, we have demonstrated that both multiphoton (1, 2 and 3 photon)-induced fluorescence (MPEF) and laser-induced breakdown (LIB) emissions are strongly enhanced in the backward direction. The backward enhancement increases from 1.8 to 35 (emission ratio between the backward direction and 90degrees) with increasing non-linear process order n. Application to non-linear lidar of biological aerosols is discussed. C1 Univ Lyon 1, LASIM, UMR 5579, F-69622 Villeurbanne, France. US Army Res Lab, Adelphi, MD 20783 USA. Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA. RP Wolf, JP (reprint author), Univ Lyon 1, LASIM, UMR 5579, 43 11 Novembre, F-69622 Villeurbanne, France. RI Wolf, Jean-Pierre/B-8315-2012 OI Wolf, Jean-Pierre/0000-0003-3729-958X NR 37 TC 22 Z9 27 U1 1 U2 7 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD SEP PY 2002 VL 75 IS 2-3 BP 145 EP 152 DI 10.1007/s00340-002-0970-0 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA 609PJ UT WOS:000178913900002 ER PT J AU Smith, DH Madsen, JD Dickson, KL Beitinger, TL AF Smith, DH Madsen, JD Dickson, KL Beitinger, TL TI Nutrient effects on autofragmentation of Myriophyllum spicatum SO AQUATIC BOTANY LA English DT Article DE Eurasian watermilfoil; Myriophyllum spicatum; autofragment; nitrogen; vegetative reproduction; propagules ID EURASIAN WATERMILFOIL; GROWTH; MACROPHYTES; VEGETATION; METABOLISM; LAKE AB The effects sediment nitrogen and water potassium concentrations have on autofragment production of Eurasian watermilfbil (Myriophyllum spicatum L.) were studied utilizing 16 mesocosms with four mesocosms per treatment. Results indicated that a sediment nitrogen concentration of 0.04 mg NH3-Ng(-1) sediment significantly increased autofragment production. Plants grown for 12 weeks in this low nitrogen regime produced 1616 autofragments while high nitrogen treated plants (0.55 mg NH3-Ng-1 sediment) produced 712 autofragments. Potassium concentration did not significantly alter autofragment production. Up to 50% of autofragments abscised from parent plants grown under low nitrogen conditions compared to 12% or less when grown under high nitrogen conditions. Within 10 days of initiating adventitious roots, 16-38% of autofragments broke away from parent plants grown under low nitrogen regimes compared to 10% of autofragments grown under high nitrogen regimes. Plant components (inflorescence, autofragment; stem and root crown) contained equivalent percentages of total nonstructural carbohydrates (TNCs) by the 9th week of growth; however, low nitrogen treated plants were producing more autofragment and stem biomass. The combination of these factors indicates that Eurasian watermilfoil grown in a low nitrogen environment directs more resources toward autofragment and stem production, allowing colonization of new potential sites. In contrast, when grown in a high nitrogen environment, this species directs more of its energy toward stem and root crown development, allowing for regrowth and colonization in the immediate area. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75056 USA. Minnesota State Univ, Mankato Biol Sci Dept, Trafton Sci Ctr S242, Mankato, MN 56001 USA. Univ N Texas, Inst Appl Sci, Denton, TX 76203 USA. Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA. RP Smith, DH (reprint author), USA, Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 1 Fish Hatchery Rd, Lewisville, TX 75056 USA. NR 19 TC 22 Z9 23 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 J9 AQUAT BOT JI Aquat. Bot. PD SEP PY 2002 VL 74 IS 1 BP 1 EP 17 AR PII S0304-3770(02)00023-2 DI 10.1016/S0304-3770(02)00023-2 PG 17 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 588BU UT WOS:000177681200001 ER PT J AU Perkins, EJ Streever, WJ Davis, E Fredrickson, HL AF Perkins, EJ Streever, WJ Davis, E Fredrickson, HL TI Development of amplified fragment length polymorphism markers for Spartina alterniflora SO AQUATIC BOTANY LA English DT Article DE AFLP; salt marsh; smooth cordgrass; transplanted ID SAN-FRANCISCO BAY; GENETIC DIVERSITY; GULF COASTS; CALIFORNIA; EVOLUTION; POACEAE; AFLP; POPULATION; ATLANTIC; USA AB Spartina alterniflora Loisel. plants have been transported across great distances for use in wetland restoration and creation projects. However, little information exists on the geographic genetic structure of S. alterniflora, such as the relatedness of populations within a region and the genetic similarity of imported populations to native populations. A high-resolution tool for assessing genetic similarity and diversity of S. altemiflora populations would be an important step toward understanding these relationships. We optimized a bead beater extraction and amplified fragment length polymorphism (AFLP) protocol for S. alterniflora and evaluated its usefulness in distinguishing plants from adjacent marshes in addition to marshes planted with imported stock. Two primer sets were used in AFLP analysis of four to five plants from each of seven populations. These primer sets generated 372 scoreable loci, of which 235 were polymorphic. High genetic diversity was observed in all populations studied, with nucleofide diversities ranging from 0.0363 to 0.0651. Results from analysis of molecular variance (AMOVA) in this exploratory, analysis indicated that intrapopulation genetic diversity was high (59.8% of total variation). The contribution of regional differences was weak. Geographical distances between planting stock origin and native marshes did not correlate with genetic diversity. This study demonstrated the procedure could be used to rapidly and reproducibly generate high-resolution genetic profiles of individual plants. The data produced with this method will be used to further our understanding of the structure of S. altemiflora communities and their function in salt marshes. (C) 2002 Elsevier Science B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. AScI Corp, Mclean, VA 22101 USA. RP Perkins, EJ (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 30 TC 14 Z9 18 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 J9 AQUAT BOT JI Aquat. Bot. PD SEP PY 2002 VL 74 IS 1 BP 85 EP 95 AR PII S0304-3770(02)00046-3 DI 10.1016/S0304-3770(02)00046-3 PG 11 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 588BU UT WOS:000177681200007 ER PT J AU Kroumpouzos, G Frank, EW Albertini, MJG Krivo, JM Ramsey, ML Tyler, WB Cohen, LM AF Kroumpouzos, G Frank, EW Albertini, MJG Krivo, JM Ramsey, ML Tyler, WB Cohen, LM TI Lentigo maligna with spread onto oral mucosa SO ARCHIVES OF DERMATOLOGY LA English DT Article ID MOHS MICROGRAPHIC SURGERY; RUSH PERMANENT SECTIONS; MELANOMA; SKIN; PROGRESSION; EXCISION AB Background: Lentigo maligna (LM) is a form of melanoma in situ most often seen in white patients on unexposed areas, primarily the head and neck. Spread of LM onto the conjunctiva has been reported. There have been no reports of LM extending onto oral mucosa. Observations: We report 4 cases of LM in white women with contiguous spread from perioral areas to oral mucosa. The locations of the primary lesions were the vermilion of the lip, vermilion and perioral skin, cheek, and cutaneous aspect of the lip. Three cases showed focal histopathologic evidence of invasion during the course of the disease. The lesions ran a prolonged course characterized by repeated recurrences after surgery. Three of the cases required a complicated reconstruction after surgical excision. Mobs surgery with rush permanent (paraffin-embedded) sections resulted in a long remission in 2 cases, while in 1 patient, treatment with carbon dioxide laser was unsuccessful. Conclusions: In a perioral distribution, LM can spread onto oral mucosa. This clinical presentation may cause significant long-term morbidity, as indicated by a high recurrence rate and/or progression to invasive melanoma. The oral mucosa should be examined in patients with atypical pigmented perioral lesions. C1 Vet Affairs Med Ctr, Dept Dermatol, Brockton, MA USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Dermatol, Cambridge, MA 02138 USA. Tufts Univ, Sch Med, New England Med Ctr, Dept Dermatol, Boston, MA 02155 USA. Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Geisinger Med Ctr, Dept Pathol, Danville, PA 17822 USA. Cohen Dermatopathol PC, Newton, MA USA. RP Cohen, LM (reprint author), 320 Needham St,Suite 200, Newton, MA 02464 USA. OI Kroumpouzos, George/0000-0002-5915-4640 NR 37 TC 7 Z9 7 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD SEP PY 2002 VL 138 IS 9 BP 1216 EP 1220 DI 10.1001/archderm.138.9.1216 PG 5 WC Dermatology SC Dermatology GA 593DN UT WOS:000177976100015 PM 12224983 ER PT J AU Samet, ED AF Samet, ED TI Teaching poetry to soldiers in a post-heroic age SO ARMED FORCES & SOCIETY LA English DT Article AB In antiquity the epic poet's need for the soldier was reciprocated. Today, however, poets and soldiers operate in an altered relation. The association of poetry with often violent action is very much alive, yet the once intertwined existence of soldier and poet-an incorporation that perhaps reached its apex in the figure of the World War I soldier-poet-has been replaced by diffidence, curiosity, and sometimes distrust. This climate of estrangement notwithstanding, poetry thrives at the United States Military Academy, where all plebes take a core curriculum literature class. Cadets emerge from this class with a recognition of the long-standing connections between literature and war; of the historical role of poetry in shaping culture, attitudes, and values; and of the ongoing imperative for military officers to be able to use language with precision. Moreover, by exercising the cadets' imaginations, the study of poetry helps to cultivate the powers of anticipation and invention these young men and women will need as military professionals in an unsettled, unsettling world. C1 US Mil Acad, Dept English, W Point, NY 10996 USA. RP Samet, ED (reprint author), US Mil Acad, Dept English, W Point, NY 10996 USA. NR 39 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 2002 VL 29 IS 1 BP 109 EP + DI 10.1177/0095327X0202900106 PG 20 WC Political Science; Sociology SC Government & Law; Sociology GA 631QF UT WOS:000180177900005 ER PT J AU Clauw, DJ Engel, CC Donta, S Barkhuizen, A Skinner, JS Peduzzi, P Guarino, P Williams, DA Taylor, T Kazis, L Feussner, JR AF Clauw, DJ Engel, CC Donta, S Barkhuizen, A Skinner, JS Peduzzi, P Guarino, P Williams, DA Taylor, T Kazis, L Feussner, JR CA the CSP Study Grp TI Effectiveness of aerobic exercise and cognitive Behavioral therapy in 1092 veterans with chronic multisymptom illnesses: Results from CSP #470. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 66th Annual Scientific Meeting of the American-College-of-Rheumatology/37th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 24-29, 2002 CL NEW ORLEANS, LOUISIANA SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 Univ Michigan, Ann Arbor, MI 48109 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. VAMC, Boston, MA USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. Indiana Univ, Indianapolis, IN 46204 USA. VA Cooperat Trials Coordinating Ctr, West Haven, CT USA. White River Junct VA, White River Jct, VT USA. VAMC, Bedford, MA USA. VA Res & Dev, Washington, DC USA. RI Williams, David/A-1180-2007 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2002 VL 46 IS 9 SU S BP S106 EP S107 PG 2 WC Rheumatology SC Rheumatology GA 600ZN UT WOS:000178421800216 ER PT J AU Jonsson, MK Kim, X Bruner, G Dennis, G Rubertone, M Harley, J James, JA AF Jonsson, MK Kim, X Bruner, G Dennis, G Rubertone, M Harley, J James, JA TI Hydroxychloroquine sulfate (Plaquenil) may delay the onset of systemic lupus erythematosus. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 66th Annual Scientific Meeting of the American-College-of-Rheumatology/37th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 24-29, 2002 CL NEW ORLEANS, LOUISIANA SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Univ Bergen, Broegelmann Res Lab, Bergen, Norway. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2002 VL 46 IS 9 SU S BP S291 EP S291 PG 1 WC Rheumatology SC Rheumatology GA 600ZN UT WOS:000178421800758 ER PT J AU Hagedorn, M Lance, SL Fonseca, DM Kleinhans, FW Artimov, D Fleischer, R Hoque, ATMS Hamilton, MB Pukazhenthi, BS AF Hagedorn, M Lance, SL Fonseca, DM Kleinhans, FW Artimov, D Fleischer, R Hoque, ATMS Hamilton, MB Pukazhenthi, BS TI Altering fish embryos with aquaporin-3: An essential step toward successful cryopreservation SO BIOLOGY OF REPRODUCTION LA English DT Article DE embryo ID BRACHYDANIO-RERIO EMBRYOS; WATER CHANNEL PROTEINS; PERMEABILITY BARRIER; OSMOMETRIC BEHAVIOR; ZEBRAFISH EMBRYOS; XENOPUS OOCYTES; EXPRESSION; GLYCEROL; FAMILY; CELLS AB Fish populations are globally threatened by over-harvesting and habitat degradation. The ability to bank fish embryos by cryopreservation could be crucial for preserving species diversity, for aquaculture (allowing circannual fish farming), and for managing fish models used in human biomedical research. However, no nonmammalian embryo has ever been successfully cryopreserved. For fish, low membrane permeability prevents cryoprotectants from entering the yolk to prevent cryodamage. Here, we present evidence of a membrane mechanism hindering cryopreservation of fish and propose a novel solution to this obstacle. Zebrafish (Danio rerio) embryos have rectifying membranes that allow water to leave but not to reenter readily. This feature may be an evolutionary trait that allows freshwater embryos to grow in hypo-osmotic environments without osmoregulatory organs. However, this trait may also prevent successful fish embryo cryopreservation because both water and cryoprotectants must move into and out of cells. As a solution, we injected zebrafish embryos with mRNA for the aquaporin-3 water channel protein and demonstrated increased membrane permeability to water and to a cryoprotectant. Modeling indicates that sufficient cryoprotectant enters aquaporin-3-expressing zebrafish embryos to allow cryopreservation. C1 Smithsonian Inst, Natl Zool Pk, Dept Reprod Sci, Washington, DC 20008 USA. Smithsonian Inst, Conservat & Res Ctr, Washington, DC 20008 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. Indiana Univ Purdue Univ, Dept Phys, Indianapolis, IN 46202 USA. Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA. Smithsonian Inst, Natl Zool Pk, Dept Zool Res, Washington, DC 20008 USA. Smithsonian Inst, Natl Zool Pk, Mol Genet Lab, Washington, DC 20008 USA. US FDA, Ctr Biol Evaluat & Res, Lab Plasma Derivat, Div Hematol, Bethesda, MD 20892 USA. Georgetown Univ, Dept Biol, Washington, DC 20057 USA. RP Hagedorn, M (reprint author), Smithsonian Inst, Natl Zool Pk, Dept Reprod Sci, 3001 Connecticut Ave NW, Washington, DC 20008 USA. EM hagedornm@nzp.si.edu RI Lance, Stacey/K-9203-2013; OI Lance, Stacey/0000-0003-2686-1733; Fonseca, Dina/0000-0003-4726-7100 FU NCRR NIH HHS [K01 RR00135, R01 RR08769] NR 38 TC 54 Z9 59 U1 2 U2 10 PU SOC STUDY REPRODUCTION PI MADISON PA 1603 MONROE ST, MADISON, WI 53711-2021 USA SN 0006-3363 J9 BIOL REPROD JI Biol. Reprod. PD SEP PY 2002 VL 67 IS 3 BP 961 EP 966 DI 10.1095/biolreprod.101.002915 PG 6 WC Reproductive Biology SC Reproductive Biology GA 587WZ UT WOS:000177668200036 PM 12193408 ER PT J AU Xu, P Kumar, J Samuelson, L Cholli, AL AF Xu, P Kumar, J Samuelson, L Cholli, AL TI Monitoring the enzymatic polymerization of 4-phenylphenol by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: A novel approach SO BIOMACROMOLECULES LA English DT Editorial Material ID POLYMERS; MS AB Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is a powerful tool for polymer characterization. It has been used to understand the enzymatic polymerization of 4-phenylphenol and to monitor number average molecular weight and weight average molecular weight of the polymer as a function of systematic addition of hydrogen peroxide (H2O2) in the reaction. A novel method, an introduction of internal standard for quantification of data, has been developed for MALDI-TOF MS to investigate the fate of each mers during the reaction. The preliminary data suggest that this approach provides new insight on the enzymatic synthesis, which is not available by other techniques. For the first time, we are able to understand the fate of several mers as a function of reaction conditions. The relative content of each mer increases with the addition of H2O2, except for dimer and trimer. For example, the concentration of dimer species decreases as a function of H2O2. On the other hand, the concentration of trimer species increases first and then decreases in the course of the reaction. C1 Univ Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. Univ Lowell, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Cholli, AL (reprint author), Univ Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. NR 16 TC 31 Z9 32 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD SEP-OCT PY 2002 VL 3 IS 5 BP 889 EP 893 DI 10.1021/bm0255600 PG 5 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 592XX UT WOS:000177963100002 PM 12217031 ER PT J AU Roy, S Fortier, JM Nagarajan, R Tripathy, S Kumar, J Samuelson, LA Bruno, FF AF Roy, S Fortier, JM Nagarajan, R Tripathy, S Kumar, J Samuelson, LA Bruno, FF TI Blomimetic synthesis of a water soluble conducting molecular complex of polyaniline and lignosulfonate SO BIOMACROMOLECULES LA English DT Article ID ENZYMATIC-SYNTHESIS; LIGNIN; ACID) AB A new biomimetic route for the synthesis of a conducting molecular complex of polyaniline (Pani) and a natural polyelectrolyte, lignosulfonate (LGS) is presented. A poly(ethylene glycol) modified hematin (PEG-hematin) was used to catalyze the polymerization of aniline in the presence of LGS to form a Pani/LGS complex. UV-vis, FTIR, conductivity and TGA studies for the LGS-polyaniline complex indicate the presence of a thermally stable and electrically conductive form of polyaniline. Also the presence of LGS in this complex, an inexpensive byproduct from pulp processing, provides a unique combination of properties such as electronic conductivity, processability and biodegradability. The use of this conductive complex for corrosion protection is also proposed. C1 Univ Massachusetts Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. USA, Soldier Biol & Chem Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. NR 34 TC 74 Z9 82 U1 4 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD SEP-OCT PY 2002 VL 3 IS 5 BP 937 EP 941 DI 10.1021/bm0255138 PG 5 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 592XX UT WOS:000177963100009 PM 12217038 ER PT J AU Zhang, T Ng, P Caridha, D Leach, RA Asher, LV Novak, MJ Smith, WJ Zeichner, SL Chiang, PK AF Zhang, T Ng, P Caridha, D Leach, RA Asher, LV Novak, MJ Smith, WJ Zeichner, SL Chiang, PK TI Gene expressions in Jurkat cells poisoned by a sulphur mustard vesicant and the induction of apoptosis SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Article DE sulphur mustard vesicant; 2-chloroethylethyl sulphide; apoptosis; caspases; microarray; Bcl; Akt; PDK ID PROTEIN-KINASE-B; SULFUR MUSTARD; 2-CHLOROETHYLETHYL SULFIDE; BAD PHOSPHORYLATION; C-MYC; ACTIVATION; TOXICOLOGY; NITROGEN; INVITRO; DEATH AB 1 The sulphur mustard vesicant 2-chloroethylethyl sulphide (CEES) induced apoptosis in Jurkat cells. 2 Akt (PKB), a pivotal protein kinase which can block apoptosis and promotes cell survival, was identified to be chiefly down-regulated in a dose-dependent manner following CEES treatment. Functional analysis showed that the attendant Akt activity was simultaneously reduced. 3 PDK1, an upstream effector of Akt, was also down-regulated following CEES exposure, but two other upstream effectors of Akt, PI3-K and PDK2, remained unchanged. 4 The phosphorylation of Akt at Ser(473) and Thr(308) was significantly decreased following CEES treatment, reflecting the suppressed kinase activity of both PDK1 and PDK2. 5 Concurrently, the anti-apoptotic genes, Bcl family, were down-regulated, in sharp contrast to the striking up-regulation of some death executioner genes, caspase 3, 6, and 8. 6 Based on these findings, a model of CEES-induced apoptosis was established. These results suggest that CEES attacked the Akt pathway, directly or indirectly, by inhibiting Akt transcription, translation, and post-translation modification. 7 Taken together, upon exposure to CEES, apoptosis was induced in Jurkat cells via the down-regulation of the survival factors that normally prevent the activation of the death executioner genes, the caspases. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. NCI, NIH, Bethesda, MD 20892 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NICHHD, NIH, Bethesda, MD 20892 USA. RP Chiang, PK (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. NR 40 TC 1 Z9 1 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD SEP PY 2002 VL 137 IS 2 BP 245 EP 252 DI 10.1038/sj.bjp.0704856 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 593NQ UT WOS:000177998700014 ER PT J AU Matthew, CB Bastille, AM Gonzalez, RR Sils, IV AF Matthew, CB Bastille, AM Gonzalez, RR Sils, IV TI Heart rate variability and electrocardiogram waveform as predictors of morbidity during hypothermia and rewarming in rats SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY LA English DT Article DE hypothermia; rewarming; heart rate variability; ECG; blood pressure ID REPOLARIZATION; MANIFESTATIONS; MECHANISMS; CELLS AB This study examined electrocardiogram (ECG) waveform, heart rate (HR), mean blood pressure (BP), and HR variability as potential autonomic signatures of hypothermia and rewarming. Adult male Sprague-Dawley rats had telemetry transmitters surgically implanted, and 2 weeks were allowed for recovery prior to induction of hypothermia. Rats were lightly anesthetized (sodium pentobarbital, 35 mg/kg i.p.) and placed in a coil of copper tubing through which temperature-controlled water was circulated. Animals were cooled to a core temperature (T-c) of 20degreesC, maintained there for 30 min, and then rewarmed. Data (T-c, BP, HR from ECG, and 10-s strips of ECG waveforms) were collected every 5 min throughout hypothermia and rewarming. Both HR and BP declined after initial increases with the drop in HR starting at a higher T-c than the drop in BP (29.6 +/- 2.4degreesC vs. 27.1 +/- 3.3degreesC, p < 0.05). Animals that were not successfully rewarmed exhibited a significant (p < 0.05) increase in the normalized standard deviation of interbeat intervals (IBI) throughout cooling compared with animals that were successfully rewarmed. The T wave of the ECG increased in amplitude and area with decreasing T-c. T-wave amplitude and IBI variability show potential as predictors of survival in hypothermic victims. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Matthew, CB (reprint author), USA, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. NR 31 TC 12 Z9 13 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA, ONTARIO K1A 0R6, CANADA SN 0008-4212 J9 CAN J PHYSIOL PHARM JI Can. J. Physiol. Pharmacol. PD SEP PY 2002 VL 80 IS 9 BP 925 EP 933 DI 10.1139/Y02-120 PG 9 WC Pharmacology & Pharmacy; Physiology SC Pharmacology & Pharmacy; Physiology GA 607YD UT WOS:000178817600011 PM 12430988 ER PT J AU Schlembach, PJ Wilder, RB Jones, D Ha, CS Fayad, LE Younes, A Hagemeister, F Hess, M Cabanillas, F Cox, JD AF Schlembach, PJ Wilder, RB Jones, D Ha, CS Fayad, LE Younes, A Hagemeister, F Hess, M Cabanillas, F Cox, JD TI Radiotherapy alone for lymphocyte-predominant Hodgkin's disease SO CANCER JOURNAL LA English DT Article DE lymphocyte-predominant Hodgkin's disease; radiotherapy ID EUROPEAN TASK-FORCE; PROGNOSTIC FACTORS; CLINICAL PRESENTATION; MANTLE IRRADIATION; RISK; CLASSIFICATION; CHEMOTHERAPY; PROJECT; REVEALS; PATTERN AB PURPOSE The purpose of the study was to analyze the results with radiotherapy alone in a select group of asymptomatic adults with nonbulky, early-stage lymphocyte-predominant Hodgkin's disease. PATIENTS AND METHODS Between 1963 and 1995, 36 patients with nonbulky stage IA (N = 27) or IIA (N = 9) supradiaphragmatic (N = 27) or subdiaphragmatic (N = 9) lymphocyte-predominant Hodgkin's disease were treated with radiotherapy alone. Eleven of the patients underwent laparotomy. Limited-field radiotherapy involving only one side of the diaphragm and extended-field radiotherapy encompassing both sides of the diaphragm were used in 28 and 8 cases, respectively. Median dose to involved areas was 40.0 Gy given daily in 202.0-Gy fractions. Salvage treatment consisted of MOPP (mechlorethamine, vincristine, prednisone, procarbazine), CVPP/ABDIC (cyclophosphamide, vinblastine, procarbazine and prednisone/doxorubicin, bleomycin, dacarbazine, lomustine, and prednisone), or ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy and/or involved-field radiotherapy. RESULTS Median follow-up was 8.8 years (range, 3.0-34.4 years). None of the 15 patients with supradiaphragmatic disease who received limited-field radiotherapy to regions that did not include the mediastinal or hilar nodes subsequently experienced relapse there. Only one of 20 patients who received supradiaphragmatic limited-field radiotherapy alone experienced relapse in the paraaortic nodes or spleen. The 5-year relapse-free and overall survival rates for the 20 patients with stage IA lymphocyte-predominant Hodgkin's disease treated with involved-field or regional radio-therapy were 95% and 100%, respectively. There were no cases of severe or life-threatening cardiac toxicity. No solid tumors have been observed in-field in patients treated with limited-field radiotherapy, even though they have been followed up longer than those treated with extended-field radiotherapy (median follow-up, 11.6 vs 5.5 years); two solid tumors have developed in-field in patients who received extended-field radiotherapy. DISCUSSION Involved-field or regional radiotherapy alone may be adequate in stage IA lymphocyte-predominant Hodgkin's disease patients. Longer follow-up will help to more clearly define the risks of cardiac toxicity and solid tumors that result from involved-field or regional radiotherapy, which appear to be low based on follow-up to date. C1 Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA. Univ Texas, MD Anderson Canc Ctr, Dept Hematopatol, Houston, TX 77030 USA. Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma, Houston, TX 77030 USA. RP Wilder, RB (reprint author), Walter Reed Army Med Ctr, Dept Radiat Oncol, 6800 Georgia Ave NW, Washington, DC 20407 USA. RI Jones, Daniel/I-7399-2015 FU NCI NIH HHS [CA 16672, CA 6294] NR 42 TC 40 Z9 42 U1 0 U2 1 PU JONES AND BARTLETT PUBLISHERS PI SUDBURY PA 40 TALL PINE DR, SUDBURY, MA 01776 USA SN 1528-9117 J9 CANCER J JI Cancer J. PD SEP-OCT PY 2002 VL 8 IS 5 BP 377 EP 383 DI 10.1097/00130404-200209000-00008 PG 7 WC Oncology SC Oncology GA 609FZ UT WOS:000178894100007 PM 12416895 ER PT J AU Kim, DW Blumstein, A Kumar, J Samuelson, LA Kang, B Sung, C AF Kim, DW Blumstein, A Kumar, J Samuelson, LA Kang, B Sung, C TI Ordered multilayer nanocomposites prepared by electrostatic layer-by-layer assembly between aluminosilicate nanoplatelets and substituted ionic polyacetylenes SO CHEMISTRY OF MATERIALS LA English DT Article ID POLYELECTROLYTE MULTILAYERS; STEPWISE FORMATION; ULTRATHIN FILMS; DEPOSITION; ORIENTATION; COMPOSITES; MONTMORILLONITE; POLYCATIONS; ADSORPTION; MECHANISM AB Ordered multilayer nanocomposites have been prepared by electrostatic layer-by-layer assembly between exfoliated aluminosilicate nanoplatelets and substituted ionic polyacetylenes. Aluminosilicate saponite particles were exfoliated by means of extensive shaking and sonication of their water suspension. Atomic force microscopy and transmission electron microscopy data suggest that the exfoliated platelets have the shape of ultrathin disks with an average width of 170+/-30 nm. Conjugated ionic polyacetylene poly(N-octadodecyl-2-ethynylpyridinium bromide) (PEPy-C18) was synthesized by spontaneous polymerization of 2-ethynylpyridine quaternized with 1-bromooctadecane. Linear build-up of multilayer nanocomposites between the exfoliated saponite particles and substituted ionic polyacetylenes was monitored by T-TV-vis absorption spectroscopy. AFM surface topography of the resulting films indicates that the saponite platelets cover the entire surface of the underlying layers. TEM cross-sectional images of such films show that the saponite platelets are aligned parallel to the film surface to form ordered layers. Polarized UV-vis absorption spectroscopy suggests that the polyacetylene chains are oriented parallel to the surface of the saponite layers. C1 Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Dept Chem & Phys, Lowell, MA 01854 USA. USA, Soldier & Biol Chem Command, Natick Sodier Ctr, Natick, MA 01760 USA. RP Blumstein, A (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. OI KIM, DONG WOOK/0000-0002-0752-5366 NR 36 TC 37 Z9 37 U1 0 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD SEP PY 2002 VL 14 IS 9 BP 3925 EP 3929 DI 10.1021/cm0203823 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 595VH UT WOS:000178128900044 ER PT J AU Helman, DL Byrd, JC Ales, NC Shorr, AF AF Helman, DL Byrd, JC Ales, NC Shorr, AF TI Fludarabine-related pulmonary toxicity - A distinct clinical entity in chronic lymphoproliferative syndromes SO CHEST LA English DT Article DE chronic lymphocytic leukemia; drug toxicity; fludarabine ID CHRONIC LYMPHOCYTIC-LEUKEMIA; AUTOIMMUNE HEMOLYTIC-ANEMIA; INTERSTITIAL PNEUMONITIS; THERAPY; INFECTIONS; PHOSPHATE; PATIENT; MONOPHOSPHATE; LISTERIOSIS; RISK AB Background: Little is known about lung injury caused by fludarabine therapy. Objectives: To establish a case definition, to describe management, and to identify risk factors for fludarabine-related pulmonary toxicity. Design: Case-control study. Setting: Tertiary-care US Army teaching hospital. Patients: Individuals treated with fludarabine at our institution between January 1989 and June 2000. Measurements: Cases of fludarabine-related pulmonary toxicity were defined as follows: dyspnea, fever, hypoxemia, and radiographic infiltrates seen in a patient treated with fludarabine; cases were excluded if there was evidence of pulmonary infection or progression of underlying lymphoproliferative disease affecting the lungs. For each case, demographic data, medical history, radiographic information, available bronchoscopy and pathology data, and details of treatment were reviewed. Cases were compared with fludarabine-treated control subjects to identify potential risk factors. Comparisons were made with regard to age, gender, history of underlying lung disease, lymphoproliferative diagnosis, prior chemotherapy, fludarabine treatment regimen, and pretreatment chest radiograph. Results: During the study period, 105 patients were treated with fludarabine. The incidence of fludarabine-related pulmonary toxicity using our definition was 8.6% (95% confidence interval [CI], 3.2 to 13.9%). One patient died before this entity was suspected; the remainder of the patients underwent bronchoscopy to exclude infection. Patients were treated with corticosteroids with subjective and objective benefits. One patient later died of apparent infection during steroid therapy. One patient was retreated with fludarabine and symptoms of lung toxicity developed again. Patients (n = 9) were similar to control subjects (n = 96) with respect to age, gender, history of underlying lung disease, previous chemotherapy, and fludarabine regimen. Patients with chronic lymphocytic leukemia were 13.3 (95% CI, 1.6 to 300.6) times more likely to have toxicity develop than patients treated with fludarabine for other diagnoses. There was a trend toward an increased incidence in patients with interstitial infiltrates apparent on prefludarabine chest radiographs. Conclusions: A variety of lung conditions arise in patients treated with fludarabine; however, this agent seems to cause direct pulmonary toxicity. After performing an appropriate evaluation to exclude infection, corticosteroids are an effective therapy. The relative frequency of this condition and potential for mortality underscore the need for increased clinician awareness of fludarabine-related pulmonary toxicity and its risk factors. C1 Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Hematol & Oncol Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Allergy & Immunol Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Ohio State Univ, Div Hematol & Oncol, Columbus, OH 43210 USA. RP Helman, DL (reprint author), Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 29 TC 30 Z9 30 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2002 VL 122 IS 3 BP 785 EP 790 DI 10.1378/chest.122.3.785 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 593KK UT WOS:000177990300009 PM 12226014 ER PT J AU Seriwatana, J Shrestha, MP Scott, RM Tsarev, SA Vaughn, DW Myint, KSA Innis, BL AF Seriwatana, J Shrestha, MP Scott, RM Tsarev, SA Vaughn, DW Myint, KSA Innis, BL TI Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; DIAGNOSIS; ANTIBODY; EPITOPES; VIREMIA; IGM AB Diagnosis of acute hepatitis E by detection of hepatitis E virus (HEV)-specific immunoglobulin M (IgM) is an established procedure. We investigated whether quantitation of HEV IgM and its ratio to HEV total Ig furnished more information than conventional IgM tests that are interpreted as positive or negative. A previously described indirect immunoassay for total Ig against a baculovirus-expressed HEV capsid protein was modified to quantitate HEV-specific IgM in Walter Reed (WR) antibody units by using a reference antiserum and the four-parameter logistic model. A receiver-operating characteristics curve derived from 197 true-positive specimens and 449 true-negative specimens identified 30 WR units/ml as an optimum cut point. The median HEV IgM level in 36 patients with acute hepatitis E fell from 3,000 to 100 WR units/ml over 6 months, suggesting that 100 WR units/ml would be a more appropriate cut point for distinguishing recent from remote IgM responses. Among three hepatitis E case series, determination of the HEV IgM-to-total-Ig ratio in acute-phase serum revealed that most patients had high ratios consistent with primary infections whereas a few had low ratios, suggesting that they had sustained reinfections that elicited ananinestic antibody responses. The diagnostic utility of the new IgM test was similar to that of a commercially available test that uses different HEV antigens. In conclusion, we found that HEV IgM can be detected specifically in >95% of acute hepatitis E cases defined by detection of the virus genome in serum and that quantitation of HEV IgM and its ratio to total Ig provides insight into infection timing and prior immunity. C1 Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA. Armed Forces Res Inst Med Sci, Res Unit, Kathmandu, Nepal. Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Innis, BL (reprint author), GlaxoSmithKline, 1250 S Collegeville Rd,Mail Code UP 4330, Collegeville, PA 19426 USA. NR 18 TC 44 Z9 47 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD SEP PY 2002 VL 9 IS 5 BP 1072 EP 1078 DI 10.1128/CDLI.9.5.1072-1078.2002 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 591UB UT WOS:000177897700021 PM 12204962 ER PT J AU Sundar, S Sahu, M Mehta, H Gupta, A Kohli, U Rai, M Berman, JD Murray, HW AF Sundar, S Sahu, M Mehta, H Gupta, A Kohli, U Rai, M Berman, JD Murray, HW TI Noninvasive management of Indian visceral leishmaniasis: Clinical application of diagnosis by K39 antigen strip testing at a kala-azar referral unit SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID DIRECT AGGLUTINATION-TEST; POLYMERASE-CHAIN-REACTION; RECOMBINANT K-39; FIELD DIAGNOSIS; CLONED ANTIGEN; CHAGASI; SUDAN AB Firm diagnosis of visceral leishmaniasis (kala-azar) requires organ aspiration and microscopic examination of tissue specimens. To determine the usefulness of noninvasive diagnosis by strip test detection of anti-K39 immunoglobulin (Ig) G antibody in blood specimens obtained by fingerstick, 143 Indian patients with suspected kala-azar (fever, splenomegaly, anemia) were studied. Of 120 strip test-positive subjects (subjects with presumed kala-azar [group A]), amphotericin B treatment induced clinical cure in 119. Of 23 strip test-negative subjects (subjects presumed to have other diseases [group B]), 16 had other disorders diagnosed at entry, 4 responded to empiric antimalarial therapy, 2 were proven to have kala-azar, and 1 died elsewhere after undergoing splenic aspiration. Six months after treatment ended, all 120 patients in group A and the 18 assessable patients in group B were healthy. In a region in India where visceral infection is prevalent, strip test detection of anti- K39 IgG is a clinically promising diagnostic guide in persons with suspected kala-azar. C1 Banaras Hindu Univ, Inst Med Sci, Kala Azar Med Res Ctr, Dept Med, Varanasi 221005, Uttar Pradesh, India. Walter Reed Army Inst Res, Silver Spring, MD USA. Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA. RP Sundar, S (reprint author), 6 SK Gupta Nagar, Varanasi 211005, Uttar Pradesh, India. NR 29 TC 39 Z9 40 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD SEP 1 PY 2002 VL 35 IS 5 BP 581 EP 586 DI 10.1086/342057 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 583VJ UT WOS:000177431000012 PM 12173133 ER PT J AU Seehusen, DA Glorioso, JE AF Seehusen, DA Glorioso, JE TI Tamoxifen as an ergogenic agent in women body builders SO CLINICAL JOURNAL OF SPORT MEDICINE LA English DT Editorial Material ID GYNECOMASTIA C1 Tripler Army Med Ctr, Dept Family Practice & Emergency Med Serv, Tripler, HI 96859 USA. RP Seehusen, DA (reprint author), Tripler Army Med Ctr, Dept Family Practice & Emergency Med Serv, Tripler, HI 96859 USA. NR 10 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1050-642X J9 CLIN J SPORT MED JI Clin. J. Sport Med. PD SEP PY 2002 VL 12 IS 5 BP 313 EP 314 DI 10.1097/01.JSM.0000013902.55003.A8 PG 2 WC Orthopedics; Physiology; Sport Sciences SC Orthopedics; Physiology; Sport Sciences GA 603EZ UT WOS:000178547000010 PM 12394205 ER PT J AU DeLeon, PH Dunivin, DL Newman, R AF DeLeon, PH Dunivin, DL Newman, R TI The tide rises SO CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE LA English DT Article DE psychopharmacology; prescriptive authority; pharmacotherapy; prescribing psychologists; training ID PSYCHOPHARMACOLOGY DEMONSTRATION PROJECT AB Much as the professional school movement of 30 years ago was first considered misguided by opponents and ultimately became a valuable part of the profession, so too will prescriptive authority for psychologists. One major step was APA's Council of Representatives' adoption as formal policy attaining prescriptive authority. Training models in psychopharmacology for psychologists have emerged around the country. Even in advance of a state's adoption of prescription privileges statute, participation in such training results in enhanced scope of clinical competence and practice. A substantial body of data has emerged about psychologists' practice of pharmacotherapy. Four independent evaluations of the DoD psychopharmacology fellowship demonstrated that psychologists can be trained to safely and effectively prescribe medications and integrate pharmacotherapy into psychological practice. C1 Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20307 USA. Amer Psychol Assoc, Washington, DC 20002 USA. RP Dunivin, DL (reprint author), Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20307 USA. NR 15 TC 3 Z9 3 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0969-5893 J9 CLIN PSYCHOL-SCI PR JI Clin. Psychol.-Sci. Pract. PD FAL PY 2002 VL 9 IS 3 BP 249 EP 255 DI 10.1093/clipsy/9.3.249 PG 7 WC Psychology, Clinical SC Psychology GA 584MT UT WOS:000177470900002 ER PT J AU Brence, JR Brown, DE AF Brence, JR Brown, DE TI Data mining corrosion from eddy current non-destructive tests SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE data mining; knowledge discovery; regression trees; corrosion; complexity; Ockham's razor AB Quicker, more effective methods of corrosion prediction and classification can help to ensure a safe and operational transportation system for both civilian and military sectors. This is especially critical now as transportation providers attempt to meet the increased expense of repairing aging aircraft with smaller budgets. These budget constraints make it imperative to find corrosion and to correctly determine the appropriate time to replace corroded parts. If the part is replaced too soon, the result is wasted resources. However, if the part is not replaced soon enough, it could cause a catastrophic accident. The discovery of models that limit the possibility of a costly accident while optimizing resource utilization would allow transportation providers to efficiently focus their maintenance efforts. While our concern in this study was with aircraft, the results will also be useful to other transportation providers. This paper describes the discovery and comparison of empirical models to predict corrosion damage from non-destructive test (NDT) data. The NDT data were derived from eddy current (EC) scans of the United States Air Force's (USAF) KC-135 aircraft. While we might suspect a link between NDT results and corrosion, up until now this link has not been formally established. Instead, the NDT data have been converted into false color images that are analyzed visually by maintenance operators. The models we discovered are quite complex and suggest that with the appropriate data mining approaches we can sometimes more effectively handle noisy data through more complex models rather than simpler ones. Our results also show that while a variety of modeling techniques can predict corrosion with reasonable accuracy, regression trees are particularly effective in modeling the complex relationships between the EC measurements and the actual amount of corrosion. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 US Mil Acad, Dept Syst Engn, W Point, NY 10996 USA. Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22903 USA. RP Brence, JR (reprint author), US Mil Acad, Dept Syst Engn, W Point, NY 10996 USA. NR 15 TC 9 Z9 10 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-8352 J9 COMPUT IND ENG JI Comput. Ind. Eng. PD SEP PY 2002 VL 43 IS 4 BP 821 EP 840 AR PII S0360-8352(02)00142-0 DI 10.1016/S0360-8352(02)00142-0 PG 20 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA 596FE UT WOS:000178152900013 ER PT J AU Hamoush, S McGinley, M Mlakar, P Terro, MJ AF Hamoush, S McGinley, M Mlakar, P Terro, MJ TI Out-of-plane behavior of surface-reinforced masonry walls SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE shear strength; out-of-plane; concrete masonry; fiber reinforced composites; experimental testing AB This paper presents the results of an experimental program designed to evaluate the out-of-plane shear strength of masonry wall system; and to evaluate of the influence of the area of externally bonded FRP composites on the shear strength of the system. Eighteen compact masonry wall panels (3'X2'X8", 900X600X200 mm) were tested for static out-of-plane loads. Nine panels were reinforced by one layer of WEB 'S-Glass' fiber-reinforcing system attached to the tension side of the wall, while the remaining nine were reinforced with two layers of composite overlay on the tension side. The influence of the overlay's embedded length (the distance between the support and the overlay's end) on the shear strength was also investigated. The variables evaluated included three layout configurations and two reinforcement ratios. Three different distances between the overlay end and the adjacent support were tested, 0, d/4 (d is the block unit thickness) and d/2. Both one and two layers of WEB fibers were used and three specimens were evaluated for each variable. An MTS machine was used to test each panel under four-point load conditions. The failure loads, mid-span deflection, fiber-end slippage and failure modes were recorded. Based on the results of the experimental program, it appears that the out-of-plane shear strength of the concrete masonry wall systems is constant over the range of variables tested. The measured shear strength of the masonry wall specimens evaluated in this program indicates that the code defined shear strengths may not be as conservative as assumed. (C) 2002 Elsevier Science Ltd. All rights reserved. C1 N Carolina Agr & Tech State Univ, Architectural Engn Dept, Greensboro, NC 27411 USA. Waterways Expt Stn, Construct & Mat Div, Vicksburg, MS USA. Kuwait Univ, Dept Civil Engn, Safat 1300, Kuwait. NR 10 TC 22 Z9 23 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD SEP PY 2002 VL 16 IS 6 BP 341 EP 351 AR PII S0950-0618(02)00024-7 DI 10.1016/S0950-0618(02)00024-7 PG 11 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 591FY UT WOS:000177870100004 ER PT J AU Jones, TA Larson, SR Nielson, DC Young, SA Chatterton, NJ Palazzo, AJ AF Jones, TA Larson, SR Nielson, DC Young, SA Chatterton, NJ Palazzo, AJ TI Registration of P-7 bluebunch wheatgrass germplasm SO CROP SCIENCE LA English DT Article C1 Utah State Univ, USDA ARS, Forage & Range Res, Logan, UT 84322 USA. Utah State Univ, Utah Crop Improvement Assoc, Logan, UT 84322 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Jones, TA (reprint author), Utah State Univ, USDA ARS, Forage & Range Res, Logan, UT 84322 USA. NR 6 TC 9 Z9 10 U1 0 U2 0 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 USA SN 0011-183X J9 CROP SCI JI Crop Sci. PD SEP-OCT PY 2002 VL 42 IS 5 BP 1754 EP 1755 PG 2 WC Agronomy SC Agriculture GA 592GG UT WOS:000177928000061 ER PT J AU Scobell, A AF Scobell, A TI China and North Korea: The close but uncomfortable relationship SO CURRENT HISTORY LA English DT Article C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Scobell, A (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. NR 2 TC 1 Z9 1 U1 0 U2 1 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 USA SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD SEP PY 2002 VL 101 IS 656 BP 278 EP 283 PG 6 WC International Relations; Political Science SC International Relations; Government & Law GA 588EY UT WOS:000177689600007 ER PT J AU Scobell, A AF Scobell, A TI Protracted contest: Sino-Indian rivalry in the twentieth century SO CURRENT HISTORY LA English DT Book Review C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Scobell, A (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 USA SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD SEP PY 2002 VL 101 IS 656 BP 294 EP 295 PG 2 WC International Relations; Political Science SC International Relations; Government & Law GA 588EY UT WOS:000177689600010 ER PT J AU Elston, DM AF Elston, DM TI What's eating you? Tarantulas (Theraphosidae) SO CUTIS LA English DT Article ID OPHTHALMIA NODOSA; HAIRS C1 Brooke Army Med Ctr, San Antonio, TX USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17822 USA. EM dmelston@geisinger.edu NR 14 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD SEP PY 2002 VL 70 IS 3 BP 162 EP 163 PG 2 WC Dermatology SC Dermatology GA 595WZ UT WOS:000178132700004 PM 12353890 ER PT J AU Reed, DS Smoll, J Gibbs, P Little, SF AF Reed, DS Smoll, J Gibbs, P Little, SF TI Mapping of antibody responses to the protective antigen of Bacillus anthracis by flow cytometric analysis SO CYTOMETRY LA English DT Article DE microspheres; immunoassay; competition; neutralizing antibody; anthrax; vaccine; mapping ID IN-VITRO CORRELATE; MONOCLONAL-ANTIBODIES; INHALATIONAL ANTHRAX; LETHAL FACTOR; TOXIN; IMMUNOASSAY; IMMUNITY; BINDING; MODEL AB Background: Knowledge of the target and functional capability of the antibody response against an antigen provides more specific and relevant information about protective immunity than measuring the total amount of antibody produced against an antigen. Methods: Using flow cytometry, a competitive assay has been created for measuring the antibody response against important epitopes of an antigen. Monoclonal antibodies (mAbs) against the protective antigen (PA) component of Bacillus abstracts are available that neutralize the activity of lethal toxin (LeTx). Flow cytometric analysis revealed that these mAbs bind PA conjugated to polystyrene latex microspheres. Results: Unlabeled mAbs against PA competed with fluorescent mAbs that bind the homologous epitope but not with fluorescent mAbs that bind heterologous epitopes. Four-parameter logistic models were developed for measuring the antibody response against two epitopes of PA. Sera from anthrax-vaccinated rabbits inhibited the binding of fluorescent mAbs to either epitope; the degree of inhibition correlated with the dilution of sera. Conclusions: The response in the rabbit sera to either epitope on PA depended on the dose of vaccine administered to the rabbits. No inhibition was seen with sera from control animals. With no species-specific components, this assay could be adapted readily for comparing responses between species. C1 USA, Med Res Inst Infect Dis, Div Toxinol & Aerobiol, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Bacteriol, Frederick, MD 21702 USA. RP Reed, DS (reprint author), USA, Med Res Inst Infect Dis, Div Toxinol & Aerobiol, 1425 Porter St, Frederick, MD 21702 USA. OI Reed, Douglas/0000-0003-0076-9023 NR 15 TC 15 Z9 16 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0196-4763 J9 CYTOMETRY JI Cytometry PD SEP 1 PY 2002 VL 49 IS 1 BP 1 EP 7 DI 10.1002/cyto.10134 PG 7 WC Biochemical Research Methods; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 589WK UT WOS:000177784400001 PM 12210604 ER PT J AU Bose, M AF Bose, M TI Comment: Defining US foreign policy in the post-9/11 world SO DIPLOMATIC HISTORY LA English DT Article C1 US Mil Acad, W Point, NY 10996 USA. RP Bose, M (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 16 TC 0 Z9 0 U1 0 U2 2 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0145-2096 J9 DIPLOMATIC HIST JI Dipl. Hist. PD FAL PY 2002 VL 26 IS 4 BP 619 EP 626 DI 10.1111/1467-7709.00330 PG 8 WC History SC History GA 594RL UT WOS:000178064600007 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI A thermal stabilizer for LiPF6-based electrolytes of Li-ion cells SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID LITHIUM BATTERY ELECTROLYTES; CHELATE COMPLEX; SPINEL; BORON; SALT AB We report that tris(2,2,2- trifluoroethyl) phosphite (TTFP), in which the oxidization number of phosphor is three (III), can effectively improve thermal stability of LiPF6-based electrolytes of Li-ion cells. Effect of TTFP on the performance of Li/graphite, Li/cathode, and Li-ion cells is estimated using cyclic voltammetry and galvanostatic cycling. Results show that TTFP is electrochemically stable in Li-ion chemistry. We also found that TTFP can prevent propylene carbonate (PC) decomposition and graphite exfoliation in Li/graphite half-cell. We propose a mechanism of TTFP protecting LiPF6 and discuss the effect of TTFP on cell performance. (C) 2002 The Electrochemical Society. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 12 TC 29 Z9 31 U1 3 U2 27 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PD SEP PY 2002 VL 5 IS 9 BP A206 EP A208 DI 10.1149/1.1499669 PG 3 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 586EZ UT WOS:000177572800007 ER PT J AU Thorn, KA Pennington, JC Hayes, CA AF Thorn, KA Pennington, JC Hayes, CA TI M-15 NMR investigation of the reduction and binding of TNT in an aerobic bench scale reactor simulating windrow composting SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ANAEROBIC/AEROBIC TREATMENT; SOIL/MOLASSES MIXTURES; N-15-TNT RESIDUES; COVALENT BINDING; HUMIC SUBSTANCES; 2,4,6-TRINITROTOLUENE; SPECTROSCOPY; SOIL; FATE AB (TNT)-N-15 was added to a soil of low organic carbon content and composted for 20 days in an aerobic bench scale reactor The finished whole compost and fulvic acid humic acid humin and lignocellulose fractions extracted from the compost were analyzed by solid state CP/MAS and DP/MAS N-15 NMR N-15 NMR spectra provided direct spectroscopic evidence for reduction of TNT followed by covalent binding of the reduced metabolites to organic matter of the composted soil with the majority of metabolite found in the lignocellulose fraction by mass also the major fraction of the compost In general the types of bonds formed between soil organic matter and reduced TNT amines in controlled laboratory reactions were observed in the spectra of the whole compost and fractions confirming that during composting TNT is reduced to amines that form covalent bonds with organic matter through aminohydro quinone aminoquinone heterocyclic and imine linkages among others Concentrations of imine nitrogens in the compost spectra suggest that covalent binding by the diammes 24DANT and 26DANT is a significant process in the transformation of TNT into bound residues Liquid phase N-15 NMR spectra of the fulvic acid and humin fractions provided possible evidence for involvement of phenoloxidase enzymes in covalent bond formation. C1 US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. USA Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. DynTel, Vicksburg, MS 39180 USA. RP Thorn, KA (reprint author), US Geol Survey, Denver Fed Ctr, POB 25046 MS 408, Denver, CO 80225 USA. NR 33 TC 42 Z9 43 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 1 PY 2002 VL 36 IS 17 BP 3797 EP 3805 DI 10.1021/es011382r PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 591PH UT WOS:000177889100033 PM 12322753 ER PT J AU Frattarelli, JL Levi, A Miller, BT Segars, JH AF Frattarelli, JL Levi, A Miller, BT Segars, JH TI Basal antral follicle number predicts IVF cycle pregnancy, cancellation, and ovarian responsiveness: A prospective study. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 12-17, 2002 CL SEATTLE, WASHINGTON SP Amer Soc Reproduct Med C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. Combined Fed Program Reprod Endocrinol, NIH, Bethesda, MD USA. Reprod Med Assoc New Jersey, Morristown, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2002 VL 78 IS 3 SU 1 MA O114 BP S44 EP S44 DI 10.1016/S0015-0282(02)03495-7 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 597UP UT WOS:000178239400115 ER PT J AU Preen, AE McKeeby, JL Catherino, W Alvero, RJ AF Preen, AE McKeeby, JL Catherino, W Alvero, RJ TI Oral misoprostol prior to operative hysteroscopy does not enhance cervical dilation or improve operative time: A prospective randomized, double blind, placebo-controlled trial. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 12-17, 2002 CL SEATTLE, WASHINGTON SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2002 VL 78 IS 3 SU 1 MA O208 BP S79 EP S80 DI 10.1016/S0015-0282(02)03589-6 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 597UP UT WOS:000178239400209 ER PT J AU Winter, WE Krivak, TC Maxwell, L Elkas, JC Rose, GS Carlson, JW AF Winter, WE Krivak, TC Maxwell, L Elkas, JC Rose, GS Carlson, JW TI Modified technique for urinary diversion with incontinent conduits SO GYNECOLOGIC ONCOLOGY LA English DT Article DE urinary diversion; incontinent urinary conduit; pelvic surgery AB Background. Incontinent urinary diversions are frequently performed in gynecologic oncology. The incontinent urinary diversions generally utilize a short segment of distal ileum or colon as a conduit. Conduit complications such as anastomosis leaks and strictures may be related to the technique utilized for inserting and securing the ureters and the degree of postimplant manipulation. Technique. We describe a technique using a metal Yankaur suction device placed through the conduit's matured stoma to facilitate the mucosa-to-mucosa anastomosis of the ureters. This procedure allows for tension-free ureteral anastomoses, the isolation of the ideal conduit length, optimal stomal maturation, and reduced manipulation of the conduit after the ureteral anastomoses. Conclusion. This modification provides an elegant, yet simple and expedient, method of ureteral anastomosis to the incontinent urinary conduit. (C) 2002 Elsevier Science (USA). C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. RP Carlson, JW (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Bldg 2,Room 6761,6900 Georgia Ave NW, Washington, DC 20307 USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 2002 VL 86 IS 3 BP 351 EP 353 DI 10.1006/gyno.2002.6768 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 592YT UT WOS:000177965000019 PM 12217759 ER PT J AU Showalter, DE AF Showalter, DE TI More than nuts and bolts: Technology and the German army, 1870-1945 SO HISTORIAN LA English DT Article C1 US Mil Acad, W Point, NY 10996 USA. RP Showalter, DE (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 43 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 2002 VL 65 IS 1 BP 123 EP 143 DI 10.1111/1540-6563.651019 PG 21 WC History SC History GA 631FC UT WOS:000180156600006 ER PT J AU Epstein, JE Gorak, EJ Charoenvit, Y Wang, RB Freydberg, N Osinowo, O Richie, TL Stoltz, EL Trespalacios, F Nerges, J Ng, J Fallarme-Majam, V Abot, E Goh, L Parker, S Kumar, S Hedstrom, RC Norman, J Stout, R Hoffman, SL AF Epstein, JE Gorak, EJ Charoenvit, Y Wang, RB Freydberg, N Osinowo, O Richie, TL Stoltz, EL Trespalacios, F Nerges, J Ng, J Fallarme-Majam, V Abot, E Goh, L Parker, S Kumar, S Hedstrom, RC Norman, J Stout, R Hoffman, SL TI Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes SO HUMAN GENE THERAPY LA English DT Article ID PLASMID DNA; PROTECTIVE EFFICACY; IMMUNE-RESPONSES; CIRCUMSPOROZOITE PROTEIN; MONOCLONAL-ANTIBODIES; AOTUS MONKEYS; VIRUS; IMMUNOGENICITY; IMMUNIZATION; INDUCTION AB Introduction of a new vaccine requires choosing a delivery system that provides safe administration and the desired level of immunogenicity. The safety, tolerability, and immunogenicity of three monthly 2.5-mg doses of a PfCSP DNA vaccine were evaluated in healthy volunteers as administered intramuscularly (IM) by needle, IM by jet injection (Biojector(R)) or IM/intradermally (ID) by jet injection. Vaccine administration was well-tolerated. Adverse events were primarily mild and limited to the site of injection (98%). Jet injections (either IM or ID) were associated with approximately twice as many adverse events per immunization as needle IM, but nevertheless were strongly and consistently preferred in opinion polls taken during the study. No volunteers had clinically significant biochemical or hematologic changes or detectable anti-dsDNA antibodies. In conclusion, the injection of Plasmodium falciparum circumsporozoite (PfCSP) DNA vaccine appeared to be safe and well-tolerated when administered by any of the three modes of delivery. However, despite improved antibody responses following both jet injection and ID delivery in animal models, no antibodies could be detected in volunteers by immunofluorescence antibody test (IFAT) or enzyme-linked immunosorbent assay (ELISA) after DNA vaccination. C1 USN, Malaria Program, Med Res Ctr, Silver Spring, MD 20910 USA. USA, Med Res Inst Infect Dis, Dept Clin Studies, Ft Detrick, MD 21702 USA. USN, US Dept Def, Bone Marrow Donor Program, Med Res Ctr, Rockville, MD 20852 USA. Vical Inc, San Diego, CA 92121 USA. Bioject Inc, Portland, OR 97224 USA. RP Epstein, JE (reprint author), USN, Malaria Program, Med Res Ctr, 503 Robert Grant Ave,Room 3W34, Silver Spring, MD 20910 USA. RI Richie, Thomas/A-8028-2011; OI Denham, Nicole/0000-0002-4618-7144 NR 57 TC 68 Z9 69 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD SEP PY 2002 VL 13 IS 13 BP 1551 EP 1560 DI 10.1089/10430340260201644 PG 10 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 588YX UT WOS:000177730800002 PM 12228010 ER PT J AU Laxminarayan, S Kun, LG AF Laxminarayan, S Kun, LG TI Combating bioterrorism with bioengineering SO IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE LA English DT Editorial Material C1 USA, IEEE, Med Technol Policy Comm, Washington, DC USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0739-5175 J9 IEEE ENG MED BIOL JI IEEE Eng. Med. Biol. Mag. PD SEP-OCT PY 2002 VL 21 IS 5 BP 21 EP 27 DI 10.1109/MEMB.2002.1044155 PG 7 WC Engineering, Biomedical; Medical Informatics SC Engineering; Medical Informatics GA 605FU UT WOS:000178667500005 PM 12405054 ER PT J AU Kun, LG AF Kun, LG TI Homeland security: The possible, probable, and perils of information technology SO IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE LA English DT Article C1 Rutgers State Univ, CIMIC, Piscataway, NJ 08855 USA. RP Kun, LG (reprint author), USA, IEEE, Med Technol Policy Comm, Washington, DC USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 0739-5175 J9 IEEE ENG MED BIOL JI IEEE Eng. Med. Biol. Mag. PD SEP-OCT PY 2002 VL 21 IS 5 BP 28 EP 33 DI 10.1109/MEMB.2002.1044157 PG 6 WC Engineering, Biomedical; Medical Informatics SC Engineering; Medical Informatics GA 605FU UT WOS:000178667500007 PM 12405055 ER PT J AU Liu, JJ Riely, B Shen, PH Das, N Newman, P Chang, W Simonis, G AF Liu, JJ Riely, B Shen, PH Das, N Newman, P Chang, W Simonis, G TI Ultralow-threshold sapphire substrate-bonded top-emitting 850-nm VCSEL array SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE lasing threshold; oxide aperture; polarization; sapphire substrate; spectral linewidth; vertical-cavity surface-emitting laser ID VERTICAL-CAVITY LASERS; OPTICAL INTERCONNECTS; APERTURE; OXIDATION; LEVEL; CHIP AB Oxide-confined top-emitting vertical-cavity surface-emitting-laser (VCSEL) 8 x 8 arrays were designed and fabricated with ultralow thresholds. The arrays were flip-chip bonded onto sapphire substrates and mounted in pin-grid-array packages as optical transmitter arrays. By using the offset-contact bonding process, we were able to obtain very high yield for hybridized devices without damaging the VCSEL mesas. Room-temperature lasing thresholds below 70 muA were found from some of these packaged VCSELs with measured oxide apertures 2.6 mum in diameter. The emission spectrum at an injection current of 70 muA showed a full-width at half-maximum linewidth of less than 2.5 Angstrom. Polarization properties were also confirmed from the output of the device. The superior performance was attributed to the optimized size and placement of the confinement aperture and the precise alignment of the gain profile of the active region to the mode of the resonant cavity. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Liu, JJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. NR 12 TC 9 Z9 9 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD SEP PY 2002 VL 14 IS 9 BP 1234 EP 1236 DI 10.1109/LPT.2002.801093 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 594VJ UT WOS:000178071900002 ER PT J AU Li, T Joshi, RP del Rosario, RD AF Li, T Joshi, RP del Rosario, RD TI Requirements for low intermodulation distortion in GaN-AlxGa1-xN high electron mobility transistors: A model assessment SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE distortion; GaN; high-electron mobility transistor (HEMT); intermodulation; Monte Carlo (MC) ID ALGAN-GAN HETEROSTRUCTURES; FIELD-EFFECT TRANSISTORS; LIGHT-EMITTING-DIODES; MONTE-CARLO METHOD; WURTZITE GAN; INVERSION LAYER; TRANSPORT; SEMICONDUCTORS; SCATTERING; HEMTS AB A model analysis of the large-signal characteristics of GaN-AlxGa1-xN high-electron mobility transistors (HEMTs) with particular emphasis on intermodulation distortion (IMD) and the third-order intercept point. Since the nonlinearity depends critically on the carrier transport behavior, a Monte Carlo (MC) based numerical simulation scheme has been employed. The focus is to identify parameters and their interdependencies with a view of setting optimal limits for enhanced microwave performance. A case is made for increased mole fraction for the barrier layer, reducing the transit length, and introducing a thin AlN interfacial layer for suppressing real space transfer for enhancing the device performance. Finally, high-temperature predictions of the nonlinear behavior and IMD have been made, by carrying out the MC simulations at 600 K. In a process a favorable case is made for the GaN system as a potential candidate for microwave and RF applications at elevated temperatures. C1 Filtron Solid State Inc, Santa Clara, CA 95054 USA. Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Filtron Solid State Inc, Santa Clara, CA 95054 USA. NR 56 TC 9 Z9 9 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD SEP PY 2002 VL 49 IS 9 BP 1511 EP 1518 DI 10.1109/TED.2002.802626 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 587XP UT WOS:000177669700002 ER PT J AU Crane, CC AF Crane, CC TI Bomber Harris: His life and times: The biography of Marshal of the Royal Air Force, Sir Arthur Harris, the wartime chief of Bomber Command SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review C1 USA, War Coll, Carlisle, PA 17013 USA. RP Crane, CC (reprint author), USA, War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY, BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD SEP PY 2002 VL 24 IS 3 BP 688 EP 690 PG 3 WC History SC History GA 589JP UT WOS:000177755400047 ER PT J AU Frances, SP Linthicum, KJ AF Frances, SP Linthicum, KJ TI Experimental infection and transmission of Orientia tsutsugamushi in adult Leptotrombidium deliense following inoculation with cultured rickettsiae SO INTERNATIONAL JOURNAL OF ACAROLOGY LA English DT Article DE Acari; Trombiculidae; Orientia tsutsugatnushi (Hayashi); Leptotroinbidium deliense (Walch); transovarial transmission; rickettsiae; Thailand ID SCRUB TYPHUS; THAILAND; TROMBICULIDAE; ACARI; ORCHARD; BANGKOK AB Strains of Orientia tsutsugamushi (Hayashi) grown in cell culture or chicken egg embryos were inoculated into uninfected Leptotrombidium deliense (Walch) adults to investigate the potential for growth and persistence of rickettsiae in mites, Adult mites were not adversely affected by the injection procedure and O. tsutsugamushi persisted for up to 14 days, Transovarial transmission of O. tsutsugamushi in the progeny of a single adult was observed for three generations. Although only 2 to 20% of larvae from this infected adult fed to repletion on mice, the transstadial transmission rate was 100% in these mites. This is the first time that this method has been used to infect adult mites with O. tsutsugamushi, resulting in transovarial and transstadial transmission. C1 Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Frances, SP (reprint author), Australian Army Malaria Inst, Gallipoli Barracks, Enoggera, Qld 4052, Australia. NR 18 TC 1 Z9 1 U1 0 U2 0 PU INDIRA PUBLISHING HOUSE PI WEST BLOOMFIELD PA P O BOX 250456, WEST BLOOMFIELD, MI 48325-0456 USA SN 0164-7954 J9 INT J ACAROL JI Int. J. Acarol. PD SEP PY 2002 VL 28 IS 3 BP 267 EP 272 PG 6 WC Entomology SC Entomology GA 673WG UT WOS:000182602800007 ER PT J AU Wang, G Wente, S Gertner, GZ Anderson, A AF Wang, G Wente, S Gertner, GZ Anderson, A TI Improvement in mapping vegetation cover factor for the universal soil loss equation by geostatistical methods with Landsat Thematic Mapper images SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article ID MARKOV-MODELS; RUSLE AB The universal soil loss equation (USLE) is a product of six factors: ( 1) rainfall erosivity, (2) soil erodibility, (3) slope length, (4) slope steepness, ( 5) cover and management, and ( 6) support practice, and is widely used to estimate average annual soil loss. The cover and management variable, called the C factor, represents the effect of cropping and management practices on erosion rates in agriculture, and the effect of ground, tree and grass canopy covers on reduction of soil loss in non-agriculture situation. This study compared three traditional and three geostatistical methods for mapping the C factor. They included vegetation classification with average, linear and log-linear regression for C factor assignment, sequential Gaussian cosimulations with and without Thematic Mapper (TM) images, and colocated cokriging with TM images. The coefficient of correlation between estimates and observations varied from 0.4888 to 0.7317, and the root mean square error ( RMSE) from 0.0159 to 0.0203. The sequential Gaussian cosimulation with a TM ratio image resulted in the highest correlation and the smallest RMSE, and reproduced the best and most detailed spatial variability of the C factor. This method may thus be recommended for mapping the C factor. It is also expected that this method could be applied to image-based mapping in other disciplines. C1 Univ Illinois, Urbana, IL 61801 USA. USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61824 USA. RP Gertner, GZ (reprint author), Univ Illinois, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. NR 25 TC 60 Z9 69 U1 4 U2 20 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD SEP PY 2002 VL 23 IS 18 BP 3649 EP 3667 DI 10.1080/01431160110114538 PG 19 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA 591BK UT WOS:000177859700009 ER PT J AU Gorton, SA Hoad, DR AF Gorton, SA Hoad, DR TI Assessment of rotor blade angle of attack from experimental inflow data SO JOURNAL OF AIRCRAFT LA English DT Article AB A series of experiments was conducted by NASA Langley Research Center and the U.S. Army, over a 10-year period beginning in the mid-1980s, to provide some insight into the nature of helicopter rotor-system-induced velocity and to provide calibration data for many promising computational methods. Rotor-induced velocities were measured above the rotor system for several forward flight-test conditions in the NASA Langley Research Center 14 by 22 Foot Subsonic Tunnel using a 15%-scale, fully articulated, stiff-in-torsion rotor and in a joint government/industry partnership with Bell Helicopter Textron, Inc., for a larger, aeroelastically scaled, bearingless rotor. A two-component laser velocimeter was used to make these measurements in the facility. The data from these tests have been published previously as NASA quick release reports and conference papers, and they are available electronically. Further analyses of the data to assess the local angle of attack of the rotor blades as a function of azimuth, span, and test condition are documented. The results indicate that assessing inflow using the time average of a rotor revolution does not always capture adequately the local effects of blade passage on the inflow distribution. The inflow distribution should be assessed using the average of the blade azimuth-dependent inflow. At advance ratios less than 0.30, the effects of the individual trailing vortices were evident in the inflow measurements, and they have a significant impact on the local blade flow angle. For higher advance ratios, the blade azimuth-dependent inflow velocities differed very little from the time-averaged inflow characteristics. The analyses demonstrated that dynamic twist is significant for aeroelastically-scaled rotors and must be measured or modeled to assess the rotor performance accurately. C1 NASA Langley Res Ctr, Flow Phys & Control Branch, Hampton, VA 23681 USA. USA, Res Lab, Load & Dynam Div, Vehicle Technol Directorate, Hampton, VA 23681 USA. RP Gorton, SA (reprint author), NASA Langley Res Ctr, Flow Phys & Control Branch, Mail Stop 170, Hampton, VA 23681 USA. NR 58 TC 2 Z9 2 U1 0 U2 3 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD SEP-OCT PY 2002 VL 39 IS 5 BP 722 EP 730 DI 10.2514/2.3010 PG 9 WC Engineering, Aerospace SC Engineering GA 603NK UT WOS:000178565800002 ER PT J AU Strawn, RC Djomehri, MJ AF Strawn, RC Djomehri, MJ TI Computational modeling of hovering rotor and wake aerodynamics SO JOURNAL OF AIRCRAFT LA English DT Article ID ROTARY-WING AERODYNAMICS; SOLVER AB Steady-state Reynolds-averaged Navier-Stokes computations are presented for a range of UH-60A model-rotor test cases in hover. The computations are designed to assess grid-related effects on the numerical results and employ 1) structured overset grids with high resolution on the rotor blades, 2) a systematic variation of grid resolution in the rotor wake, and 3) a systematic variation of outer-boundary locations. Computed rotor performance values agree very well with experimental measurements and show little sensitivity to either grid resolution or outer-boundary locations. However, the computations uniformly overpredict the blade sectional thrust near the rotor tip. This overprediction of blade tip thrust is explained by an analysis of the circulation distribution in the computed rotor wake system. C1 US Army Aviat & Missile Command, NASA Rotorcraft Div, Moffett Field, CA 94035 USA. NASA, Ames Res Ctr, Comp Sci Corp, Moffett Field, CA 94035 USA. RP Strawn, RC (reprint author), US Army Aviat & Missile Command, NASA Rotorcraft Div, Moffett Field, CA 94035 USA. NR 18 TC 29 Z9 29 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD SEP-OCT PY 2002 VL 39 IS 5 BP 786 EP 793 DI 10.2514/2.3024 PG 8 WC Engineering, Aerospace SC Engineering GA 603NK UT WOS:000178565800008 ER PT J AU Engler, RJM Kenner, J Leung, DYM AF Engler, RJM Kenner, J Leung, DYM TI Smallpox vaccination: Risk considerations for patients with atopic dermatitis SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE atopic dermatitis; eczema; smallpox; vaccinia; T cells ID VACCINIA VIRUS-INFECTION; IFN-GAMMA PRODUCTION; CD8+ T-CELLS; INTERFERON-GAMMA; IN-VIVO; LYMPHOCYTE-RESPONSES; EXPRESSION; PROTECTION; PREVALENCE; IL-4 AB As the threat of bioterrorism with pathogenic microbes such as smallpox virus (Variola major) increases, the question of widespread voluntary vaccination with smallpox (vaccinia) vaccines is being carefully considered. A major challenge lies in the ability to protect the population from the disease while minimizing the considerable side effects from the vaccine. Individuals with active or quiescent atopic dermatitis are at increased risk for vaccinia complications. The nature of these complications and other considerations are summarized in this rostrum. C1 Natl Jewish Med & Res Ctr, Dept Pediat, Div Allergy & Immunol, Denver, CO 80206 USA. Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. Dept Vet Affairs, Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI USA. Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA. RP Leung, DYM (reprint author), Natl Jewish Med & Res Ctr, Dept Pediat, Div Allergy & Immunol, 1400 Jackson St,Room K926I, Denver, CO 80206 USA. NR 72 TC 93 Z9 97 U1 0 U2 4 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD SEP PY 2002 VL 110 IS 3 BP 357 EP 365 DI 10.1067/mai.2002.128052 PG 9 WC Allergy; Immunology SC Allergy; Immunology GA 592KM UT WOS:000177936900003 PM 12209080 ER PT J AU Churley, M Robandt, PV Kuhnle, JA Lyons, TP Bruins, MR AF Churley, M Robandt, PV Kuhnle, JA Lyons, TP Bruins, MR TI Extraction of amphetamine and methamphetamine from urine specimens with Cerex Polycrom (TM) Clin II solid-phase extraction columns and the Speedisk (TM) 48 Pressure processor SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID CHROMATOGRAPHY MASS-SPECTROMETRY; GC-MS; QUANTITATION; BENZOYLECGONINE; DERIVATIZATION; EPHEDRINE; GC/MS C1 Tripler Army Med Ctr, Tripler Forens Toxicol Drug Testing Lab, Honolulu, HI 96859 USA. RP Churley, M (reprint author), Tripler Army Med Ctr, Tripler Forens Toxicol Drug Testing Lab, Bldg 40,1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 16 TC 2 Z9 3 U1 0 U2 1 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD SEP PY 2002 VL 26 IS 6 BP 347 EP 354 PG 8 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 587PC UT WOS:000177649500006 PM 12220016 ER PT J AU Larciprete, MC Sibilia, C Paoloni, S Leahu, G Li Voti, R Bertolotti, M Scalora, M Panajotov, K AF Larciprete, MC Sibilia, C Paoloni, S Leahu, G Li Voti, R Bertolotti, M Scalora, M Panajotov, K TI Thermally induced transmission variations in ZnSe/MgF2 photonic band gap structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INTERFERENCE FILTERS; BISTABILITY; FINITE AB We investigate thermally induced transmission variations in a 3.6-mum-thick ZnSe/MgF2 photonic band gap structure by means of a pump-probe setup, in the 600-700 nm range, under cw pump conditions. An induced temperature increase is responsible for the thermal expansion of the layers, as well as changes in the index of refraction. As a result, the band gap structure is redshifted by several nanometers. The initial transmission of the probe beam was restored following the removal of the pump laser, thus indicating the reversible nature of the process. (C) 2002 American Institute of Physics. C1 Univ Roma La Sapienza, INFM, I-00161 Rome, Italy. Univ Roma La Sapienza, Dipartimento Energet, I-00161 Rome, Italy. USA, Aviat & Missile Command, Weap Sci Directorate, AMSAM RD WS ST, Redstone Arsenal, AL 35898 USA. Univ Sofia, Inst Solid State Phys, Sofia, Bulgaria. RP Larciprete, MC (reprint author), Univ Roma La Sapienza, INFM, Via A Scarpa 16, I-00161 Rome, Italy. RI Li Voti, Roberto/P-5265-2014; OI Li Voti, Roberto/0000-0002-1849-2950; Larciprete, Maria Cristina/0000-0002-7876-628X NR 19 TC 20 Z9 20 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 2002 VL 92 IS 5 BP 2251 EP 2255 DI 10.1063/1.1499981 PG 5 WC Physics, Applied SC Physics GA 585WX UT WOS:000177548500005 ER PT J AU Neely, AN Bhattacharjee, AK Babcock, GF Holder, IA Cross, AS AF Neely, AN Bhattacharjee, AK Babcock, GF Holder, IA Cross, AS TI Differential effects of two different routes of immunization on protection against gram-negative sepsis by a detoxified Escherichia coli J5 lipopolysaccharide group B meningococcal outer membrane protein complex vaccine in a burned mouse model SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Article ID DISSEMINATED INTRAVASCULAR COAGULATION; PSEUDOMONAS-AERUGINOSA; EXTENDED-SPECTRUM; BETA-LACTAMASE; INFECTION; OUTBREAK; PATHOGENESIS; ENDOTOXIN; ANTIBODY; STRAIN AB Gram-negative sepsis causes morbidity and mortality in burned patients. To determine whether immunization with core endotoxin (lipopolysaccharide) via one of two routes could protect burned mice from septic death, mice were immunized either three times subcutaneously (SC) or one time intramuscularly (IM) then two times intraperitoneally (IP) with a core-lipopolysaccharide vaccine. Control mice were immunized with either saline or an irrelevant antigen. Postimmunization, mice were immunocompromised with a 15% TBSA flame burn and challenged subeschar with Klebsiella pneumoniae or Escherichia coli. Vaccine immunization improved the survival of both E. coli- and K. pnenmoniae- challenged mice when given SC but not when given IM, IP. Postimmunization, total immunoglobulin titers were elevated over preimmune titers, but titers in IM, IP-immunized mice were higher than those in SC-immunized mice. Both isotyping and flow cytometry studies indicated that sera from mice immunized via IM, IP opsonized better than sera from mice immunized via SC. Hence, this vaccine provided route-specific protection of burned mice against gram-negative sepsis; its mechanism of action was not solely dependent upon increased immunoglobulin titers or phagocytosis. C1 Univ Cincinnati, Coll Med, Shriners Hosp Children, Cincinnati, OH 45229 USA. Univ Cincinnati, Coll Med, Dept Surg, Cincinnati, OH 45229 USA. Walter Reed Army Inst Res, Dept Bacterial Dis, Washington, DC USA. Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA. RP Neely, AN (reprint author), Univ Cincinnati, Coll Med, Shriners Hosp Children, 3229 Burnet Ave, Cincinnati, OH 45229 USA. FU NIAID NIH HHS [AI 42181] NR 34 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD SEP-OCT PY 2002 VL 23 IS 5 BP 333 EP 340 DI 10.1097/01.BCR.0000028571.13767.62 PG 8 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 606ZJ UT WOS:000178765700006 PM 12352135 ER PT J AU Berti, R Williams, AJ Moffett, JR Hale, SL Velarde, LC Elliott, PJ Yao, CP Dave, JR Tortella, FC AF Berti, R Williams, AJ Moffett, JR Hale, SL Velarde, LC Elliott, PJ Yao, CP Dave, JR Tortella, FC TI Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LA English DT Article DE inflammation; cytokines; neurodegeneration; NF-kappa B; adhesion molecules; quantitative RT-PCR; MCAO ID INTERLEUKIN-1-BETA MESSENGER-RNA; FOCAL CEREBRAL-ISCHEMIA; FACTOR-KAPPA-B; POLYMERASE-CHAIN-REACTION; D-ASPARTATE ANTAGONIST; ADHESION MOLECULES; TRANSCRIPTION FACTOR; ENDOTHELIAL-CELLS; RAT MODEL; TNF-ALPHA AB Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines, some of which are regulated by the nuclear transcription factor NF-kappaB. In this study the authors examined mRNA expression levels for several important genes associated with inflammation at five time points (3, 6, 12, 24, and 72 hours) after transient middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats. A sensitive and quantitative technique (TaqMan real-time QRT-PCR) was used to simultaneously measure mRNA levels for key cell adhesion molecules and inflammatory cytokines. Gene expression increased significantly in the injured hemisphere for interleukin (IL)-1beta (12-fold increase at 24 hours), IL-6 (25-fold increase at 6 hours) and ICAM-1 (4-fold increase at 24 hours), and the interhemispheric differences for these genes were significant for every time point examined (P < 0.05 for all values). Tumor necrosis factor-a mRNA was upregulated in the injured versus uninjured hemisphere from 3 to 24 hours (5-fold increase at 6 hours), while E-selectin showed a significant increase in mRNA levels from 6 to 24 hours after MCAO (10-fold increase at 6 hours) (P < 0.05 for all values). VCAM-I mRNA levels did not respond differentially to injury at any time point between the two brain hemispheres. At all time points examined, activated NF-kappaB immunoreactivity was observed in cells throughout the infarct-damaged tissue. These results are consistent with the proinflammatory properties of the induced molecules, which are involved in the initiation of the inflammatory cascade, and may thus contribute to secondary cellular responses that lead to further brain damage. C1 Walter Reed Army Inst Res, Div Neurosci, Neuropharmacol & Mol Biol Dept, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. CombinatoRX Inc, Boston, MA USA. RP Tortella, FC (reprint author), Walter Reed Army Inst Res, Div Neurosci, Neuropharmacol & Mol Biol Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Yao, Changping/B-3619-2011 NR 52 TC 144 Z9 181 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-678X J9 J CEREBR BLOOD F MET JI J. Cereb. Blood Flow Metab. PD SEP PY 2002 VL 22 IS 9 BP 1068 EP 1079 PG 12 WC Endocrinology & Metabolism; Hematology; Neurosciences SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology GA 592CP UT WOS:000177919400004 PM 12218412 ER PT J AU Bhattacharjee, AK Kyle, DE Vennerstrom, JL Milhous, WK AF Bhattacharjee, AK Kyle, DE Vennerstrom, JL Milhous, WK TI A 3D QSAR pharmacophore model and quantum chemical structure-activity analysis of chloroquine(CQ)-resistance reversal SO JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES LA English DT Article ID RESISTANT PLASMODIUM-FALCIPARUM; CHLOROQUINE RESISTANCE; IN-VITRO; INVITRO; MALARIA; AM1; VIVO AB Using CATALYST, a three-dimensional QSAR pharmacophore model for chloroquine(CQ)-resistance reversal was developed from a training set of 17 compounds. These included imipramine (1), desipramine (2), and 15 of their analogues (3-17), some of which fully reversed CQ-resistance, while others were without effect. The generated pharmacophore model indicates that two aromatic hydrophobic interaction sites on the tricyclic ring and a hydrogen bond acceptor (lipid) site at the side chain, preferably on a nitrogen atom, are necessary for potent activity. Stereoelectronic properties calculated by using AMI semiempirical calculations were consistent with the model, particularly the electrostatic potential profiles characterized by a localized negative potential region by the side chain nitrogen atom and a large region covering the aromatic ring. The calculated data further revealed that aminoalkyl substitution at the N5-position of the heterocycle and a secondary or tertiary aliphatic amincalkyl nitrogen atom with a two or three carbon bridge to the heteroaromatic nitrogen (N5) are required for potent "resistance reversal activity". Lowest energy conformers for 1-17 were determined and optimized to afford stereoelectronic properties such as molecular orbital energies, electrostatic potentials, atomic charges, proton affinities, octanol-water partition coefficients (log P), and structural parameters. For 1-17, fairly good correlation exists between resistance reversal activity and intrinsic basicity of the nitrogen atom at the tricyclic ring system, frontier orbital energies, and lipophilicity. Significantly, nine out of 11 of a group of structurally diverse CQ-resistance reversal agents mapped very well on the 3D QSAR pharmacophore model. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD 20910 USA. Univ Nebraska, Med Ctr, Coll Pharm, Omaha, NE 68198 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 30 TC 47 Z9 49 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0095-2338 J9 J CHEM INF COMP SCI JI J. Chem. Inf. Comput. Sci. PD SEP-OCT PY 2002 VL 42 IS 5 BP 1212 EP 1220 DI 10.1021/ci0200265 PG 9 WC Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA 597ZX UT WOS:000178251600027 PM 12377011 ER PT J AU Shah, R Banks, K Patel, A Dogra, S Terrell, R Powers, PA Fenton, C Dinauer, CA Tuttle, RM Francis, GL AF Shah, R Banks, K Patel, A Dogra, S Terrell, R Powers, PA Fenton, C Dinauer, CA Tuttle, RM Francis, GL TI Intense expression of the B7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID CTLA-4 GENE POLYMORPHISM; GRAVES-DISEASE; HASHIMOTOS-THYROIDITIS; CLASS-II; CELLS; INFILTRATION; THYROCYTES; MOLECULES AB Previous observations suggest that an immune response against thyroid carcinoma could be important for long-term survival. We recently found that infiltration of thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival, but the factors that control lymphocytic infiltration and proliferation are largely unknown. We hypothesized that the antigen presentation coactivators (B7-1 and B7-2), which are important in other immune-mediated thyroid diseases, might be important in lymphocytic infiltration of thyroid carcinoma. To test this, we determined B7-1 and B7-2 expression by immunohistochemistry [absent (grade 0) to intense (grade 3)] in 27 papillary (PTC) and 8 follicular (FTC) thyroid carcinomas and 9 benign thyroid lesions. B7-1 and B7-2 were expressed by the majority of PTC and FTC (78% of PTC and 100% of FTC expressed B7-1; 88% of PTC and 88% of FTC expressed B7-2). B7-1 expression was more intense in PTC (1.4 +/- 0.2; P = 0.01) and FTC (2.6 +/- 0.2; P < 0.001) than in benign tumors (0.57 +/- 0.30) or presumably normal adjacent thyroid (0.07 +/- 0.07) and was more intense in carcinoma that contained lymphocytes (1.95 +/- 0.21) than in carcinoma that did not (1.08 +/- 0.26; P = 0.016). B7-2 expression was of similar intensity in benign and malignant tumors (PTC, 1.6 +/- 0.2; FTC, 2.1 +/- 0.4; benign, 1.86 +/- 0.4), but was more intense than in presumably normal adjacent thyroid (0.64 +/- 0.25; P less than or equal to 0.013). B7-2 expression also correlated with the number of tumor-associated lymphocytes per high power field (r = 0.38; P = 0.02). Recurrence developed exclusively from tumors that expressed B7-2, and intense B7-2 expression was associated with a reduced probability of remission (P = 0.04). In conclusion, these data support the hypothesis that the antigen presentation coactivators B7-1 and B7-2 may be important for lymphocytic infiltration and the immune response against thyroid carcinoma. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Dept Endocrinol, New York, NY 10021 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 22 TC 14 Z9 16 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD SEP PY 2002 VL 87 IS 9 BP 4391 EP 4397 DI 10.1210/jc.2002.011262 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 597BB UT WOS:000178201200060 PM 12213904 ER PT J AU Hopkins, MA Tuthill, AM AF Hopkins, MA Tuthill, AM TI Ice boom Simulations and experiments SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article DE three-dimensional models; ice jams; simulation; channels; waterways AB A three-dimensional discrete element model (DEM) was developed to simulate ice boom operation in a rectangular channel. The model simulates the motion of each individual ice floe, the interaction between adjacent floes, the interaction of the floes with the walls and boom, and the water drag applied to the floes on the underside of the ice accumulation. The DEM simulations were compared with a parallel set of physical model tests using natural ice. The DEM successfully reproduced the observed magnitude and distribution of the forces on the boom and the channel sides as the boom retained a surge of drifting ice. Variations in channel side roughness produced similar changes in the division of forces between the boom and sidewalls in the simulations and model tests. Finally, the load distribution between the boom and the channel sides and the effect of channel side roughness in the context of granular ice-jam theory were analyzed. C1 US Army Cold Reg, Res & Engn Lab, Hanover, NH 03755 USA. RP Hopkins, MA (reprint author), US Army Cold Reg, Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 17 TC 6 Z9 9 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD SEP PY 2002 VL 16 IS 3 BP 138 EP 155 DI 10.1061/(ASCE)0887-381X(2002)16:3(138) PG 18 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 584NE UT WOS:000177473000003 ER PT J AU Patel, A Fenton, C Terrell, R Powers, PA Dinauer, C Tuttle, RM Francis, GL AF Patel, A Fenton, C Terrell, R Powers, PA Dinauer, C Tuttle, RM Francis, GL TI Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE NO; thyroid cancer; VEGF; children ID HUMAN BREAST-CANCER; ARGININE METHYL-ESTER; DISEASE-FREE SURVIVAL; GROWTH-FACTOR; HUMAN THYROCYTES; YOUNG-ADULTS; EXPRESSION; CARCINOMA; ANGIOGENESIS; CELLS AB Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested this hypothesis, by staining 41 papillary thyroid carcinoma (PTC), 9 follicular thyroid carcinoma (FTC), and 15 benign thyroid lesions for iNOS, eNOS and nitrotyrosine (N-TYR). Staining intensity was determined by 2 blinded, independent examiners, and quantified from grade 1 (absent) to grade 4 (intense). Average N-TYR staining of benign adenomas (2.5+/-0.42, p=0.009), PTC (3.10+/-0.12, p=0.001), FTC (2.44+/-0.30, P=0.001), and autoimmune lesions (3.25+/-0.48, P=0.019) were greater than that of multinodular goiter (1.0 for all 3) and surrounding normal thyroid (1.1+/-0.1). Average iNOS staining of benign adenomas (2.6+/-0.37), PTC (2.7+/-0.16), FTC (2.4+/-0.26) and autoimmune lesions (3.5+/-0.29) were all greater than that of surrounding normal thyroid (0.1+/-0.1, P<0.008), but there were too few multinodular goiters to achieve a significant difference (no.=2, 3.0&PLUSMN;1.0). Average eNOS staining of benign adenomas (2.9&PLUSMN;0.40), multinodular goiters (3.5&PLUSMN;0.5), PTC (3.24&PLUSMN;0.18), FTC (3.5&PLUSMN;0.50), and autoimmune lesions (2.8&PLUSMN;0.6) were also greater than that of surrounding normal thyroid (mean=1.4&PLUSMN;0.2, p<0.001). N-TYR staining correlated with that of vascular endothelial growth factor (VEGF, r=0.36, p=0.007) and the number of lymphocytes/high power field (r=0.39, p=0.004). Recurrent disease developed only from carcinoma with moderate-intense N-TYR staining, but there were too few recurrent tumors to achieve statistical significance (p=0.08). We conclude that NO is produced by benign adenomas, PTC and FTC suggesting that NO could be important in vascularization of thyroid tumors and autoimmune thyroid diseases. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Endocrinol Sect, New York, NY 10021 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 39 TC 16 Z9 17 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILAN PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD SEP PY 2002 VL 25 IS 8 BP 675 EP 683 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 593EN UT WOS:000177978300005 PM 12240898 ER PT J AU Anderson, LM Dumsha, TC McDonald, NJ Spitznagel, JK AF Anderson, LM Dumsha, TC McDonald, NJ Spitznagel, JK TI Evaluating IL-2 levels in human pulp tissue SO JOURNAL OF ENDODONTICS LA English DT Article ID HUMAN PERIAPICAL LESIONS; IMMUNOLOGICAL ASPECTS; PROSTAGLANDIN E(2); DENTAL PULPS; CELLS; INTERLEUKIN-6; MODULATION; RESPONSES; TH1 AB In murine and human CD4+ T cell populations, there are three subpopulations of T helper cell types. Hahn et al. demonstrated the ratio of CD4/CD8 + cells significantly increases in inflamed dental pulps compared with normal pulps. Elevated levels of interleukin (IL)-2 have been detected in inflamed dental pulps and the level of IL-2 could be used as a marker for inflammation. In this study, levels of IL-2 were evaluated by using a human IL-2 cytokine assay kit on 80 samples of freshly extracted human pulp tissue. Applying standard diagnostic procedures, the tissue samples were clinically categorized into one of three experimental groups. The results demonstrated that there were no significant differences between the concentrations of IL-2 in any of the experimental groups. Our findings are different from results reported previously. Further investigation is warranted to determine if a correlation exists between the concentration of IL-2 or other interleukins and the degree of inflammation present in the dental pulp. C1 Walter Reed Army Med Ctr, Endodont Serv, Washington, DC 20307 USA. Univ Maryland, Baltimore Coll Dent Surg, Sch Dent, Dept Endodont, Baltimore, MD 21201 USA. RP Spitznagel, JK (reprint author), Baltimore Coll Dent Surg, Dept Periodont, 3C24 HHH,666 W Baltimore St, Baltimore, MD 21201 USA. NR 18 TC 10 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD SEP PY 2002 VL 28 IS 9 BP 651 EP 655 DI 10.1097/00004770-200209000-00006 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 592MU UT WOS:000177942100006 PM 12236309 ER PT J AU Deitch, AK Liewehr, FR West, LA Patton, WR AF Deitch, AK Liewehr, FR West, LA Patton, WR TI A comparison of fill density obtained by supplementing cold lateral condensation with ultrasonic condensation SO JOURNAL OF ENDODONTICS LA English DT Article ID GUTTA-PERCHA; OBTURATION TECHNIQUES AB The purpose of this study was to compare quantitatively the density of gutta-percha root canal fillings produced by cold lateral condensation with those produced by an ultrasonically energized spreader in a warm lateral condensation technique in artificial root canals. Thirty-degree simulated root canals in 30 transparent acrylic blocks were instrumented by using rotary files. The blocks were weighed. The canals were obturated with gutta-percha using cold lateral condensation without sealer and then weighed again. Two applications of warm lateral condensation were then performed on the same 30 canals using the UES. The blocks were weighed once more after each additional LIES obturation treatment. The first heat application produced a 26.92% increase in weight over lateral condensation, and the second heat application produced an additional 5.95% increase. A one-way repeated measures ANOVA followed by the Tukey-Kramer test revealed that both applications of warm lateral condensation produced significant (p < 0.001) increases in weight. Results indicate that warm lateral condensation using a ultrasonically energized spreader results in denser gutta-percha fills by weight than cold lateral condensation. C1 USA, Dent Corps, Ft Gordon, GA USA. USA, Endodont Residency Program, Ft Gordon, GA USA. RP Liewehr, FR (reprint author), USA, Dent Activ, Ft Gordon, GA 30905 USA. NR 13 TC 12 Z9 17 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD SEP PY 2002 VL 28 IS 9 BP 665 EP 667 DI 10.1097/00004770-200209000-00009 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 592MU UT WOS:000177942100009 PM 12236312 ER PT J AU Boettner, DD Paganelli, G Guezennec, YG Rizzoni, G Moran, MJ AF Boettner, DD Paganelli, G Guezennec, YG Rizzoni, G Moran, MJ TI On-board reforming effects on the performance of proton exchange membrane (PEM) fuel cell vehicles SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB This paper incorporates a methanol reformer model with a proton exchange membrane (PEM) fuel cell system model for automotive applications. The reformer model and fuel cell system model have been integrated into a vehicle performance simulator that determines fuel economy and other performance features. Fuel cell vehicle fuel economy using on-board methanol reforming is compared with fuel economy using direct-hydrogen fueling. The overall performance using reforming is significantly less than in a direct-hydrogen fuel cell vehicle. C1 US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. RP Boettner, DD (reprint author), US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. RI Rizzoni, Giorgio/D-2961-2016 OI Rizzoni, Giorgio/0000-0002-8397-7241 NR 15 TC 5 Z9 5 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0195-0738 J9 J ENERG RESOUR-ASME JI J. Energy Resour. Technol.-Trans. ASME PD SEP PY 2002 VL 124 IS 3 BP 191 EP 196 DI 10.1115/1.1488171 PG 6 WC Energy & Fuels SC Energy & Fuels GA 584NQ UT WOS:000177474100010 ER EF