TY - JOUR T1 - Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function. AN - 85230984; pmid-8402185 AB - We have demonstrated that aged rats show impairments in learning patterned motor movements. Similar behavioral impairment is observed in rats with noradrenergic lesions. Norepinephrine is known to act as a neuromodulator in the cerebellar cortex because it can augment the action of GABA and other neurotransmitters. This effect of NE to augment the signal to noise ratio of GABAergic inputs to cerebellar Purkinje neurons is a possible substrate for NE's effect on motor learning. Aged rats demonstrate deficits in the modulatory actions of NE to augment GABAergic inhibitions when both substances are locally applied onto cerebellar Purkinje neurons. In this report, we examined how motor learning and cerebellar noradrenergic function varied in individual young and 20-month-old Fischer 344 rats. There was a significant correlation between the loss of the neuromodulatory actions of norepinephrine (NE) in the cerebellar cortex and the rate of learning a novel motor task in individual rats. This report thus demonstrates for the first time a correlation between age-related impairments in motor plasticity and specific neurophysiological deficits in cerebellar Purkinje neurons in individual animals. JF - Brain Research AU - Bickford, P AD - Veterans Administration Medical Center, Denver, CO. PY - 1993 SP - 133 EP - 138 VL - 620 IS - 1 SN - 0006-8993, 0006-8993 KW - Learning KW - Support, U.S. Gov't, P.H.S. KW - Aging KW - Animal KW - Cerebellum KW - Electrophysiology KW - Learning Disorders KW - Isoproterenol KW - Rats KW - Rats, Inbred F344 KW - gamma-Aminobutyric Acid KW - Norepinephrine KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Drug Synergism KW - Male KW - Motor Activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Motor+learning+deficits+in+aged+rats+are+correlated+with+loss+of+cerebellar+noradrenergic+function.&rft.au=Bickford%2C+P&rft.aulast=Bickford&rft.aufirst=P&rft.date=1993-08-01&rft.volume=620&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Impact of chronic alcoholism on the aging rat: changes in nutrition, liver composition, and mortality. AN - 75963139; 8214425 AB - The adverse effects of chronic alcohol consumption (mean 6.68 g/kg/d) were assessed in 150 male Sprague-Dawley rats over their life span (25 months). Evaluations were performed at 2, 3, 8, 13, 19, and 25 months of age for changes in nutrition status, biochemical tests for liver injury, compositional changes in liver, and hepatic regenerative capacity. In spite of nearly identical caloric intake, alcohol treatment was associated with nutritional levels 10-30% lower than controls. Maximal changes were observed at the two extremes of ages (2-3 months and 19-25 months). Hence, a nutritional contribution to other adverse changes could not be excluded. Fatty compositional increases (triglycerides) occurred early (5-fold increases after 1 month of treatment) then declined to levels only slightly above controls. Biochemical tests on sera for liver injury (AST and total bilirubin) were consistently higher with alcohol treatment. Regenerative capacity measured by [3H]thymidine uptake after partial hepatectomy was initially elevated in the alcoholic then rapidly declined beyond 7 months of age. In control animals, an age-related decline was also observed but occurred later beyond 12 months of age. Consistent with these adverse effects, ethanol diet survival was poorer than the pair-fed control groups by 15% (median survival for alcoholics, 17 months vs. 20 months in controls. JF - Alcoholism, clinical and experimental research AU - Mendenhall, C L AU - Rouster, S D AU - Roselle, G A AU - Grossman, C J AU - Ghosn, S AU - Gartside, P AD - Department of Veterans Affairs, Veterans Administration Medical Center, Cincinnati, OH 45220. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 847 EP - 853 VL - 17 IS - 4 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Liver Regeneration -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Age Factors KW - Body Weight -- drug effects KW - Fatty Liver, Alcoholic -- pathology KW - Liver Function Tests KW - Male KW - Liver Diseases, Alcoholic -- pathology KW - Alcoholism -- pathology KW - Energy Metabolism -- drug effects KW - Longevity -- drug effects KW - Ethanol -- toxicity KW - Body Composition -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75963139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Impact+of+chronic+alcoholism+on+the+aging+rat%3A+changes+in+nutrition%2C+liver+composition%2C+and+mortality.&rft.au=Mendenhall%2C+C+L%3BRouster%2C+S+D%3BRoselle%2C+G+A%3BGrossman%2C+C+J%3BGhosn%2C+S%3BGartside%2C+P&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1993-08-01&rft.volume=17&rft.issue=4&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-11-23 N1 - Date created - 1993-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of mu-conotoxin GIIIA for the study of synaptic transmission at the frog neuromuscular junction. AN - 76053785; 8233060 AB - We have looked at the effect of synthetic mu-conotoxin GIIIA, a selective blocker of muscle Na channels, on various parameters of synaptic transmission at the frog sartorius nerve-muscle preparation. We found that 5 microM mu-conotoxin consistently blocked muscle action potentials, but had no effect on nerve action potentials. The toxin also had no effect on the amplitude or frequency of miniature endplate potentials (MEPPs), on the amplitude or time course of endplate potentials (EPPs), or on stimulation-induced changes in EPP amplitude. The lack of an effect of synthetic mu-conotoxin GIIIA on transmitter release makes this toxin an invaluable tool in the study of neuromuscular transmission under conditions of normal levels of release. JF - Neuroscience letters AU - Sosa, M A AU - Zengel, J E AD - Veterans Administration Medical Center, Gainesville, FL. Y1 - 1993/07/23/ PY - 1993 DA - 1993 Jul 23 SP - 235 EP - 238 VL - 157 IS - 2 SN - 0304-3940, 0304-3940 KW - Conotoxins KW - 0 KW - Mollusk Venoms KW - Peptides, Cyclic KW - Sodium Channels KW - conotoxin GIII KW - 101484-15-5 KW - Index Medicus KW - Rana pipiens KW - Animals KW - Peripheral Nerves -- drug effects KW - Action Potentials -- drug effects KW - Peripheral Nerves -- physiology KW - Muscles -- physiology KW - Muscles -- drug effects KW - Neuromuscular Junction -- drug effects KW - Mollusk Venoms -- pharmacology KW - Synaptic Transmission -- drug effects KW - Peptides, Cyclic -- pharmacology KW - Sodium Channels -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76053785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Use+of+mu-conotoxin+GIIIA+for+the+study+of+synaptic+transmission+at+the+frog+neuromuscular+junction.&rft.au=Sosa%2C+M+A%3BZengel%2C+J+E&rft.aulast=Sosa&rft.aufirst=M&rft.date=1993-07-23&rft.volume=157&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-14 N1 - Date created - 1993-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Four ricin chain A-based immunotoxins directed against the common chronic lymphocytic leukemia antigen: in vitro characterization. AN - 75846852; 7687163 AB - The common B-chronic lymphocytic leukemia (B-CLL) antigen (cCLLa) appears to be ideal for targeted immunotherapy in that it is the most prevalent and disease-restricted marker in B-CLL. To assess this potential, we developed four immunotoxins (ITs) of anti-cCLLa monoclonal antibody CLL2m (an IgG2a kappa), using ricin chain A (RTA) or its deglycosylated derivative (dgA), each conjugated to either the whole IgG molecule or its Fab' fragment. Each IT was tested in vitro for specificity and cytotoxic activity (assessed by protein synthesis inhibition [PSI] and by cell kill [CK] in the clonogenic assay) against B-CLL cells. RTA-based anti-CD5 ITs and enriched normal B and T lymphocytes were used as controls. Each IT exhibited antigen-specific, dose-dependent activity. Thus, whereas B-CLL cells exhibited dose-dependent PSI and CK (whether the B-CLL clone was CD5+ or CD5-), normal B (cCLLa-/CD5-) and T lymphocytes (cCLLa-/CD5+) remained unaffected. IT potency was independent of toxin glycosylation, but was slightly influenced by antibody valence; divalent ITs were twice as potent as monovalent ITs (IC50, 2.3 v 7.1 x 10(-11) mol/L; CK, 2.6- v 2.0-log reached with 524 v 1,072 IT molecules bound/cell, respectively). In the presence of ammonium chloride or Verapamil, IT-induced CK was enhanced 10- to 80-fold. These data suggest that the cCLLa is a promising target for IT-based immunotherapy of B-CLL in vivo and ex vivo. JF - Blood AU - Faguet, G B AU - Agee, J F AD - Cancer Immunology Research Laboratory, Veterans Administration Medical Center, Augusta, GA 30910. Y1 - 1993/07/15/ PY - 1993 DA - 1993 Jul 15 SP - 536 EP - 543 VL - 82 IS - 2 SN - 0006-4971, 0006-4971 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, CD5 KW - Antigens, Neoplasm KW - Antigens, Surface KW - Biomarkers, Tumor KW - Immunoglobulin Fab Fragments KW - Immunoglobulin G KW - Immunotoxins KW - Ricin KW - 9009-86-3 KW - Abridged Index Medicus KW - Index Medicus KW - Tumor Cells, Cultured KW - Kinetics KW - Immunotherapy KW - Humans KW - Cell Death KW - Glycosylation KW - Antigens, CD -- immunology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Ricin -- administration & dosage KW - Biomarkers, Tumor -- immunology KW - Ricin -- therapeutic use KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Antigens, Neoplasm -- immunology KW - Ricin -- pharmacology KW - Antigens, Surface -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75846852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Four+ricin+chain+A-based+immunotoxins+directed+against+the+common+chronic+lymphocytic+leukemia+antigen%3A+in+vitro+characterization.&rft.au=Faguet%2C+G+B%3BAgee%2C+J+F&rft.aulast=Faguet&rft.aufirst=G&rft.date=1993-07-15&rft.volume=82&rft.issue=2&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-17 N1 - Date created - 1993-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C infection by polymerase chain reaction in alcoholics: false-positive ELISA results and the influence of infection on a clinical prognostic score. AN - 85226755; pmid-8391209 AB - Antibody to hepatitis C as measured by the ELISA method is common in alcoholics. The presence of antibody to C 100-3 has been associated with more advanced disease. However, few studies have investigated the clinical significance of hepatitis C infection as defined by the presence of circulating viral RNA in alcoholics. We have prospectively examined 48 consecutive alcoholic patients for the presence of antibody to hepatitis C by an ELISA for antibody to the C100-3 antigen and by the reverse transcriptase polymerase chain reaction (PCR) using nested primers for the 5' nontranslated region of the viral RNA. Patients with liver disease were scored for disease severity by the combined clinical and laboratory index (CCLI). Overall, 12 of 48 patients (25%) were ELISA positive and eight of 48 (16%) were PCR positive. Among the 34 patients with liver disease, 10 (29%) were ELISA positive and six (18%) were PCR positive. All PCR-positive patients were also ELISA positive. There was no significant difference in the disease severity score (CCLI) or the duration of clinical disease in PCR-positive versus PCR-negative patients with liver disease. However, PCR-positive patients were significantly younger (43 +/- 6 vs. 55 +/- 10 yr, p = 0.001), indicating an earlier onset of severe disease in PCR-positive patients. There were no false-negative ELISA tests in either those with or those without liver disease. Among the 34 patients with liver disease, four of 10 patients with positive antibody were negative by PCR. Neither individual immunoglobulin levels (IgG, IgM, IgA) nor total globulins were significantly different between the ELISA-positive/PCR-negative patients and ELISA-positive/PCR-positive patients. When the entire group of 34 patients with liver disease was considered, we could not detect a significant correlation between ELISA absorbance and total globulins, and only a weak correlation between absorbance and immunoglobulin G (p = 0.49). These data show that the majority of alcoholic patients with liver disease and positive antibody to hepatitis C also have demonstrable viremia by PCR, and may require further evaluation and treatment. Elevated immunoglobulins in these patients do not correlate strongly with ELISA absorbance for anti-HCV. The presence of clinically advanced disease at a significantly younger age in the PCR-positive group is consistent with the concept of synergy between active viral infection and alcohol abuse in the development of liver disease in alcoholic patients. JF - The American Journal of Gastroenterology AU - Caldwell, S H AU - Li X AU - Rourk, R M AU - Millar, A AU - Sosnowski, K M AU - Sue, M AU - Barritt, A S AU - McCallum, R W AU - Schiff, E R AD - Salem Veterans Administration Medical Center, Virginia. PY - 1993 SP - 1016 EP - 1021 VL - 88 IS - 7 SN - 0002-9270, 0002-9270 KW - Liver Diseases, Alcoholic KW - Hepacivirus KW - Prospective Studies KW - Human KW - Alcoholism KW - Prognosis KW - Middle Age KW - Hepatitis C KW - RNA, Viral KW - Immunoglobulins KW - False Positive Reactions KW - Polymerase Chain Reaction KW - Enzyme-Linked Immunosorbent Assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Hepatitis+C+infection+by+polymerase+chain+reaction+in+alcoholics%3A+false-positive+ELISA+results+and+the+influence+of+infection+on+a+clinical+prognostic+score.&rft.au=Caldwell%2C+S+H%3BLi+X%3BRourk%2C+R+M%3BMillar%2C+A%3BSosnowski%2C+K+M%3BSue%2C+M%3BBarritt%2C+A+S%3BMcCallum%2C+R+W%3BSchiff%2C+E+R&rft.aulast=Caldwell&rft.aufirst=S&rft.date=1993-07-01&rft.volume=88&rft.issue=7&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Adenocarcinoma of a Brooke ileostomy for adenomatous polyposis coli. AN - 85224740; pmid-8391212 AB - A case of primary adenocarcinoma of a Brooke ileostomy after proctocolectomy for adenomatous polyposis coli is reported, and three additional cases collected from the literature are described. This rare tumor is seen at an average interval of 22 yr after colectomy with ileostomy. In all four cases, the mucosa adjacent to tumor had straight tubular glands lined by goblet cells and an absence of villi characteristic of colonic mucosa. Mucosal biopsies in all four stained positive for colonic sulfomucin. The clinical and morphologic features indicate a progression from ileal mucosa to colonic mucosa, colonic dysplasia, and finally, adenocarcinoma. Thirteen patients with adenocarcinoma of the ileostomy after proctocolectomy for ulcerative colitis have also been reported. Annual ileostomy examination, biopsy of suspicious lesions, and wide excision of carcinoma with stomal revision are recommended. JF - The American Journal of Gastroenterology AU - Johnson, J A AU - Talton, D S AU - Poole, G V AD - Department of Surgery, Veterans Administration Medical Center, Jackson, Mississippi. PY - 1993 SP - 1122 EP - 1124 VL - 88 IS - 7 SN - 0002-9270, 0002-9270 KW - Adenomatous Polyposis Coli KW - Human KW - Adult KW - Aged KW - Ileostomy KW - Case Report KW - Adenocarcinoma KW - Female KW - Male KW - Neoplasms, Second Primary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Adenocarcinoma+of+a+Brooke+ileostomy+for+adenomatous+polyposis+coli.&rft.au=Johnson%2C+J+A%3BTalton%2C+D+S%3BPoole%2C+G+V&rft.aulast=Johnson&rft.aufirst=J&rft.date=1993-07-01&rft.volume=88&rft.issue=7&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prevalence of hyperthyroidism in veterans hospitalized for severe cocaine dependence. AN - 75858136; 8328487 JF - The American journal of medicine AU - Burke, W M AU - Dhopesh, V P AD - Philadelphia Veterans Administration Medical Center, Pennsylvania. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 113 EP - 114 VL - 95 IS - 1 SN - 0002-9343, 0002-9343 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Veterans KW - Hospitalization KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Prevalence KW - Hyperthyroidism -- epidemiology KW - Substance-Related Disorders -- complications KW - Cocaine -- adverse effects KW - Hyperthyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75858136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Prevalence+of+hyperthyroidism+in+veterans+hospitalized+for+severe+cocaine+dependence.&rft.au=Burke%2C+W+M%3BDhopesh%2C+V+P&rft.aulast=Burke&rft.aufirst=W&rft.date=1993-07-01&rft.volume=95&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenylbutazone peroxidatic metabolism and conjugation. AN - 75836835; 8331577 AB - Phenylbutazone, a nonsteroidal anti-inflammatory drug, elicits therapeutic as well as toxic effects by unknown pathways. Phenylbutazone was shown to form a conjugate with the heterocyclic amine bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT). To understand further the reactivity of these compounds, this study was conducted to identify the conjugate formed and determine the mechanism of conjugate formation. Both prostaglandin H synthase and horseradish peroxidase catalyzed conjugate formation. This conjugate was identified by 1H-NMR to be 4-[2-amino-4-(5-nitro-2-furyl)-5-thiazolyl]-4-butyl-1,2-diphenyl-3,5- pyrazolidinedione. Phenylbutazone-mediated oxygen uptake was inhibited by ANFT (0.1 mM) and the spin traps 5,5-dimethyl-1-pyrroline-N-oxide (200 mM) and tert-nitrosobutane (4 mM). By contrast, phenol (0.005 to 0.25 mM) and aminopyrine (0.4 mM) stimulated oxygen uptake. None of these agents mediated oxygen uptake in the absence of phenylbutazone. Conjugate formation was significantly increased by phenol (0.005-0.25 mM) and aminopyrine (0.4 mM), as well as in the absence of oxygen. Conjugate formation was inhibited by 5,5-dimethyl-1-pyrroline-N-oxide (200 mM), tert-nitrosobutane (4 mM), ascorbic acid (2 mM), and 95% oxygen. Horseradish peroxidase initiated conjugate formation at much lower concentrations than it metabolized ANFT. The stoichiometric relationship between phenylbutazone and ANFT, with respect to conjugate formation, was complex. With the concentration of ANFT fixed at 0.05 mM, phenylbutazone exhibited saturation kinetics with a Km of 0.2 mM. In contrast, saturation kinetics were not observed with ANFT.Km values for ANFT varied with the concentration of phenylbutazone used.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Lakshmi, V M AU - Zenser, T V AU - Mattammal, M B AU - Davis, B B AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 81 EP - 88 VL - 266 IS - 1 SN - 0022-3565, 0022-3565 KW - Carcinogens KW - 0 KW - Peroxides KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - Horseradish Peroxidase KW - EC 1.11.1.- KW - Phenylbutazone KW - GN5P7K3T8S KW - Index Medicus KW - Peroxides -- metabolism KW - Biotransformation KW - Kinetics KW - Protein Binding KW - Chromatography, High Pressure Liquid KW - Horseradish Peroxidase -- metabolism KW - Phenylbutazone -- metabolism KW - FANFT -- pharmacokinetics KW - Carcinogens -- metabolism KW - FANFT -- analogs & derivatives KW - Carcinogens -- pharmacokinetics KW - FANFT -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75836835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Phenylbutazone+peroxidatic+metabolism+and+conjugation.&rft.au=Lakshmi%2C+V+M%3BZenser%2C+T+V%3BMattammal%2C+M+B%3BDavis%2C+B+B&rft.aulast=Lakshmi&rft.aufirst=V&rft.date=1993-07-01&rft.volume=266&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-19 N1 - Date created - 1993-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regional differences in mucosal hemodynamics in experimental colonic injury in rats. AN - 75831203; 8325183 AB - In rat colon damaged by 10% acetic acid and by dinitrochlorobenzene, we test the following hypotheses: (1) mucosal hemodynamic changes are significantly different at the ulcer base, the ulcer margin, and the inflamed non-ulcer-bearing mucosa; and (2) these mucosal hemodynamic changes also vary with time after induction of the colonic injury. Mucosal hemodynamic changes were documented by reflectance spectrophotometry, and variations in gross mucosal morphology were confirmed by hematoxylin and eosin histologic sections. Results revealed that in the acute stage, the ulcer base, which was covered by necrotic debris, showed ischemia without congestion. The ulcer margin at the edge of the ulcer base showed ischemia with congestion. The nonulcerated mucosa, which appeared erythematous, showed increased perfusion. In the convalescent stage, all the altered perfusion patterns returned to normal. These observations offer plausible explanations for the variability in colonic perfusion observed in experimentally damaged colons. JF - Digestive diseases and sciences AU - Leung, F W AU - Su, K C AU - Yonei, Y AU - Passaro, E AU - Guth, P H AD - Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1220 EP - 1223 VL - 38 IS - 7 SN - 0163-2116, 0163-2116 KW - Acetates KW - 0 KW - Dinitrochlorobenzene KW - GE3IBT7BMN KW - Acetic Acid KW - Q40Q9N063P KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Analysis of Variance KW - Ischemia -- epidemiology KW - Ulcer -- chemically induced KW - Ischemia -- physiopathology KW - Hemodynamics KW - Rats KW - Rats, Sprague-Dawley KW - Ulcer -- physiopathology KW - Ulcer -- epidemiology KW - Ischemia -- chemically induced KW - Time Factors KW - Male KW - Intestinal Mucosa -- physiopathology KW - Colonic Diseases -- chemically induced KW - Colonic Diseases -- epidemiology KW - Colonic Diseases -- physiopathology KW - Intestinal Mucosa -- blood supply KW - Colon -- physiopathology KW - Colon -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75831203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Regional+differences+in+mucosal+hemodynamics+in+experimental+colonic+injury+in+rats.&rft.au=Leung%2C+F+W%3BSu%2C+K+C%3BYonei%2C+Y%3BPassaro%2C+E%3BGuth%2C+P+H&rft.aulast=Leung&rft.aufirst=F&rft.date=1993-07-01&rft.volume=38&rft.issue=7&rft.spage=1220&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isoproterenol prevents ethanol-induced microvascular stasis and deep histologic injury in rat gastric mucosa. AN - 75828608; 8391972 AB - The effect of topical isoproterenol (5.8 x 10(-5) M) on the microvascular stasis and histologic injury produced in the rat gastric mucosa by absolute ethanol was investigated using in vivo microscopic and histologic techniques. Our findings show that in control animals, absolute ethanol applied to the gastric mucosa caused a rapid decrease in microvascular blood flow, leading to complete stasis by 3 min. In contrast, prior treatment of the gastric mucosa with topical isoproterenol increased microvascular blood flow initially and then maintained microvascular flow in the majority of microvessels studied after the application of absolute ethanol. Treatment with topical isoproterenol also reduced the histologic injury score and percent mucosal necrosis caused by absolute ethanol. Pretreatment of animals with a beta-adrenergic antagonist propranolol (2 mg/kg subcutaneously), completely blocked these protective effects. We observed no systemic effects attributable to the topical use of isoproterenol. These results indicate that prior treatment of the gastric mucosa with topical isoproterenol maintains microvascular blood flow and reduces the deep histologic injury in the stomach caused by 100% ethanol. JF - Digestive diseases and sciences AU - Howard, T J AU - Passaro, E AU - Guth, P H AD - Medical Service, Veterans Administration Medical Center, West Los Angeles, California 90073. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1201 EP - 1209 VL - 38 IS - 7 SN - 0163-2116, 0163-2116 KW - Receptors, Adrenergic, beta KW - 0 KW - Ethanol KW - 3K9958V90M KW - Propranolol KW - 9Y8NXQ24VQ KW - Isoproterenol KW - L628TT009W KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Microcirculation -- drug effects KW - Propranolol -- pharmacology KW - Blood Flow Velocity -- drug effects KW - Receptors, Adrenergic, beta -- drug effects KW - Time Factors KW - Male KW - Gastric Mucosa -- blood supply KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- pathology KW - Isoproterenol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75828608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Isoproterenol+prevents+ethanol-induced+microvascular+stasis+and+deep+histologic+injury+in+rat+gastric+mucosa.&rft.au=Howard%2C+T+J%3BPassaro%2C+E%3BGuth%2C+P+H&rft.aulast=Howard&rft.aufirst=T&rft.date=1993-07-01&rft.volume=38&rft.issue=7&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The influence of food on the absorption and metabolism of drugs. AN - 75820827; 8321071 AB - Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results from a reduction in the drug's bioavailability; however, an alteration in drug clearance can occur due to the effect of certain foods on drug metabolism. The proportion of adverse drug reactions due to food-drug interactions is not known and unfortunately only when a serious adverse drug reaction follows a food-drug interaction does the matter usually receive any significant attention. In order to improve therapeutic efficacy and to help prevent adverse drug reactions, it is necessary that clinicians be knowledgeable of the important food-drug incompatibilities and risk factors related to the increased likelihood of developing an adverse drug reaction due to food-drug interactions. JF - The Medical clinics of North America AU - Williams, L AU - Davis, J A AU - Lowenthal, D T AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Gainesville, Florida. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 815 EP - 829 VL - 77 IS - 4 SN - 0025-7125, 0025-7125 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Biological Availability KW - Food -- adverse effects KW - Intestinal Absorption KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75820827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Medical+clinics+of+North+America&rft.atitle=The+influence+of+food+on+the+absorption+and+metabolism+of+drugs.&rft.au=Williams%2C+L%3BDavis%2C+J+A%3BLowenthal%2C+D+T&rft.aulast=Williams&rft.aufirst=L&rft.date=1993-07-01&rft.volume=77&rft.issue=4&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=The+Medical+clinics+of+North+America&rft.issn=00257125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-05 N1 - Date created - 1993-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ergonovine testing and forearm plethysmography in cocaine-related myocardial ischemia. AN - 75803210; 8517415 JF - The American journal of cardiology AU - Halle, A A AU - Sullivan, J M AU - Ramanathan, K B AD - Division of Cardiovascular Disease, Veterans Administration Medical Center, Memphis, Tennessee. Y1 - 1993/07/01/ PY - 1993 DA - 1993 Jul 01 SP - 104 EP - 106 VL - 72 IS - 1 SN - 0002-9149, 0002-9149 KW - Cocaine KW - I5Y540LHVR KW - Ergonovine KW - WH41D8433D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Angina Pectoris -- chemically induced KW - Coronary Vasospasm -- chemically induced KW - Adult KW - Angina Pectoris -- complications KW - Plethysmography KW - Male KW - Coronary Vasospasm -- complications KW - Myocardial Ischemia -- etiology KW - Myocardial Ischemia -- diagnosis KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75803210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Ergonovine+testing+and+forearm+plethysmography+in+cocaine-related+myocardial+ischemia.&rft.au=Halle%2C+A+A%3BSullivan%2C+J+M%3BRamanathan%2C+K+B&rft.aulast=Halle&rft.aufirst=A&rft.date=1993-07-01&rft.volume=72&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-19 N1 - Date created - 1993-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A clinical and immunologic study of workers with trimellitic-anhydride-induced immunologic lung disease after transfer to low exposure jobs. AN - 75800452; 8317814 AB - The objective of the study was to determine the clinical and immunologic status of trimellitic anhydride (TMA) workers who have had immunologic lung diseases and who have been moved to lower exposure jobs. Twenty-nine consecutive workers with TMA-induced immunologic lung diseases who had been moved to low exposure jobs for more than 1 yr were studied retrospectively. Pulmonary symptoms were obtained by physician-administered questionnaire. Immunologic studies were performed using radioimmunoassay. Spirometry and chest film were obtained. Workers with late asthma (LA) (n = 3), late respiratory systemic syndrome (LRSS) (n = 8), or both LRSS and asthma rhinitis (A/R) (n = 6) had improved symptoms, improved pulmonary functions, and lower total antibody against TM-HSA. Five of the 12 workers with A/R had improved symptoms, improved pulmonary functions, and lower IgE against TM-HSA, whereas seven continued to have moderate to severe symptoms, abnormal pulmonary functions, and elevated IgE against TM-HSA. There were no chest film findings in any group that were definitely attributed to TMA. Although TMA workers with LA or LRSS improve when moved to lower exposure jobs, only half of workers with A/R improve; elevated IgE against TM-HSA appears to be a marker for the subpopulation of workers with A/R that does not improve. JF - The American review of respiratory disease AU - Grammer, L C AU - Shaughnessy, M A AU - Henderson, J AU - Zeiss, C R AU - Kavich, D E AU - Collins, M J AU - Pecis, K M AU - Kenamore, B D AD - Department of Medicine, Northwestern University Medical School, Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 54 EP - 57 VL - 148 IS - 1 SN - 0003-0805, 0003-0805 KW - Phthalic Anhydrides KW - 0 KW - trimellitic anhydride KW - 80T61EUU7H KW - Abridged Index Medicus KW - Index Medicus KW - Asthma -- epidemiology KW - Immunologic Tests KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Middle Aged KW - Follow-Up Studies KW - Asthma -- diagnosis KW - Asthma -- chemically induced KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Immune System Diseases -- chemically induced KW - Occupational Exposure -- statistics & numerical data KW - Lung Diseases -- diagnosis KW - Lung Diseases -- chemically induced KW - Immune System Diseases -- diagnosis KW - Occupational Exposure -- adverse effects KW - Lung Diseases -- epidemiology KW - Immune System Diseases -- epidemiology KW - Occupational Diseases -- epidemiology KW - Phthalic Anhydrides -- adverse effects KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75800452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=A+clinical+and+immunologic+study+of+workers+with+trimellitic-anhydride-induced+immunologic+lung+disease+after+transfer+to+low+exposure+jobs.&rft.au=Grammer%2C+L+C%3BShaughnessy%2C+M+A%3BHenderson%2C+J%3BZeiss%2C+C+R%3BKavich%2C+D+E%3BCollins%2C+M+J%3BPecis%2C+K+M%3BKenamore%2C+B+D&rft.aulast=Grammer&rft.aufirst=L&rft.date=1993-07-01&rft.volume=148&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-28 N1 - Date created - 1993-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circadian cancer therapy. AN - 75800004; 8315438 AB - To review briefly the growing body of published data about circadian variation in cytotoxic drug metabolism and tissue sensitivity to chemotherapeutic agents. The suggestion that toxicity may be reduced and anticancer efficacy improved by administering antineoplastic agents at carefully selected times of the day was assessed. The medical literature describing molecular, cellular, and organismic time-keeping mechanisms, as well as circadian rhythms, in cytokinetic, pharmacokinetic, and pharmacodynamic parameters relevant to cancer chemotherapy, which support the predictable rhythmic relationship between dose and effect that occurs during each day, were reviewed. Advantages for optimal circadian scheduling have been demonstrated for diminishing side effects and increasing maximal safe dose-intensity of drugs of diverse class. The use of the predictable circadian relationship of dose and response provides another increment of progress in the treatment of cancer patients. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Hrushesky, W J AU - Bjarnason, G A AD - Albany Medical College, Stratton Veterans Administration Medical Center, NY 12208. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1403 EP - 1417 VL - 11 IS - 7 SN - 0732-183X, 0732-183X KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Humans KW - Neoplasms, Experimental -- drug therapy KW - Neoplasms -- drug therapy KW - Circadian Rhythm -- physiology KW - Antineoplastic Agents -- administration & dosage KW - Neoplasms -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75800004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Circadian+cancer+therapy.&rft.au=Hrushesky%2C+W+J%3BBjarnason%2C+G+A&rft.aulast=Hrushesky&rft.aufirst=W&rft.date=1993-07-01&rft.volume=11&rft.issue=7&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-27 N1 - Date created - 1993-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat. AN - 75856685; 8338921 AB - The effects of blood pressure reduction on cyclosporine nephrotoxicity were studied over 12 months in four groups of rats. Group 1 received no drugs and served as controls. Groups 2, 3, and 4 received cyclosporine (CyA), approximately 9 mg/kg.day, in their food. In addition, Group 3 received enalapril and Group 4 received minoxidil, hydrochlorothiazide, and reserpine. Time-averaged monthly systolic blood pressure was equal in Groups 1 and 2 (136 +/- 1 and 135 +/- 1 mm Hg, respectively). Antihypertensive agents reduced average systolic blood pressure in Groups 3 and 4 (116 +/- 1 and 117 +/- 1 mm Hg, respectively). Morphometric studies showed that 12 months of CyA treatment caused interstitial fibrosis with an increase in the fractional volume of cortical interstitium (VvInt: Group 2, 20 +/- 1%; Group 1, 11 +/- 1%) and a reduction in mean glomerular volume (VG. Group 2, (2.00 +/- 0.06) x 10(6) mu 3; Group 1, (2.48 +/- 0.06) x 10(6) mu 3). These structural changes were accompanied by a significant reduction in GFR (Group 2, 2.27 +/- 0.10 mL/min; Group 1, 2.76 +/- 0.10 mL/min). Cotreatment with enalapril reduced interstitial fibrosis (VvInt, 14 +/- 1%) and maintained VG (2.23 +/- 0.08 x 10(6) mu 3) and GFR (2.56 +/- 0.08 mL/min) at near-normal values in Group 3. In contrast, the combination antihypertensive regimen increased the extent of interstitial fibrosis (VvInt, 24 +/- 1%) and further lowered VG (1.72 +/- 0.05 x 10(6) mu 3) and GFR (1.72 +/- 0.05 mL/min) in Group 4. These results show that sustained treatment with a moderate dose of CyA causes interstitial fibrosis and impairs renal function in rats. The administration of enalapril, but not minoxidil, reserpine, and hydrochlorothiazide, limits renal injury in this model. JF - Journal of the American Society of Nephrology : JASN AU - Lafayette, R A AU - Mayer, G AU - Meyer, T W AD - Department of Medicine, Palo Alto Veterans Administration Medical Center, CA. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 1892 EP - 1899 VL - 3 IS - 12 SN - 1046-6673, 1046-6673 KW - Antihypertensive Agents KW - 0 KW - Enalapril KW - 69PN84IO1A KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Proteinuria -- urine KW - Glomerular Filtration Rate -- drug effects KW - Antihypertensive Agents -- pharmacology KW - Systole KW - Enalapril -- pharmacology KW - Male KW - Cyclosporine -- blood KW - Cyclosporine -- adverse effects KW - Kidney -- pathology KW - Blood Pressure KW - Kidney -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75856685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=The+effects+of+blood+pressure+reduction+on+cyclosporine+nephrotoxicity+in+the+rat.&rft.au=Lafayette%2C+R+A%3BMayer%2C+G%3BMeyer%2C+T+W&rft.aulast=Lafayette&rft.aufirst=R&rft.date=1993-06-01&rft.volume=3&rft.issue=12&rft.spage=1892&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-31 N1 - Date created - 1993-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. AN - 75845505; 8333602 AB - Alcohol abuse leads to osteopenia and fractures. Epidemiological evidence suggests that older alcoholics are at substantially greater risk of fractures than younger alcoholics. To examine the interaction of age and alcohol abuse on bone mineral homeostasis, we studied 27 subjects with a history of 10 more years of alcohol abuse ranging in age from 26-68 years. They were evaluated for disordered bone mineral homeostasis by assessing bone density (by quantitative computed tomography of the lumbar spine), histomorphometry of a transcortical biopsy from the iliac crest, serum levels of vitamin D metabolites and parathyroid hormone, and serum and urine levels of bone minerals. Seventeen of the subjects were found to have spinal compression fractures by routine radiologic procedures. The older the subject the more likely the subject was to have such a fracture. Bone densitometry indicated a marked reduction in spinal bone density with 15 subjects below 2 SD of normal aged-matched controls. Bone density fell sharply with the age of the subject. Histomorphometry of iliac crest bone biopsies revealed no evidence of osteomalacia, but total resorption surfaces were increased. Consistent with the lack of osteomalacia were the normal levels of the vitamin D metabolites. The increased total resorption surfaces were correlated with high normal or elevated levels of parathyroid hormone as indicated both by radioimmunoassay and by urinary cAMP levels. Bone formation and active bone resorption (resorption surfaces containing osteoclasts) did not correlate with parathyroid hormone levels, however, but correlated negatively with age.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Bikle, D D AU - Stesin, A AU - Halloran, B AU - Steinbach, L AU - Recker, R AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 690 EP - 695 VL - 17 IS - 3 SN - 0145-6008, 0145-6008 KW - Parathyroid Hormone KW - 0 KW - Vitamin D KW - 1406-16-2 KW - Index Medicus KW - Space life sciences KW - Bone Density -- drug effects KW - Age Factors KW - Humans KW - Vitamin D -- blood KW - Adult KW - Fractures, Spontaneous -- blood KW - Bone Density -- physiology KW - Aged KW - Middle Aged KW - Spinal Fractures -- blood KW - Male KW - Bone Remodeling -- drug effects KW - Bone Remodeling -- physiology KW - Bone Diseases, Metabolic -- blood KW - Parathyroid Hormone -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75845505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Symptom+reduction+and+sobriety+in+the+male+alcoholic.&rft.au=Denney%2C+M+R%3BBaugh%2C+J+L&rft.aulast=Denney&rft.aufirst=M+R&rft.date=1992-11-01&rft.volume=27&rft.issue=11&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-19 N1 - Date created - 1993-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pneumonia, aseptic meningitis, and leukopenia in a 28-year-old man. AN - 75842330; 8329513 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mathisen, G E AU - Weiss, P J AU - Kennedy, C A AD - Infectious Diseases Section, Sepulveda Veterans Administration Medical Center, California. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 809 EP - 815 VL - 16 IS - 6 SN - 1058-4838, 1058-4838 KW - Index Medicus KW - Animals KW - Diagnosis, Differential KW - Ehrlichiosis -- etiology KW - Humans KW - Adult KW - Ehrlichiosis -- diagnosis KW - Bites and Stings -- complications KW - Ticks KW - Male KW - Meningitis, Aseptic -- diagnosis KW - Pneumonia -- diagnosis KW - Meningitis, Aseptic -- etiology KW - Leukopenia -- diagnosis KW - Pneumonia -- etiology KW - Leukopenia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75842330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=proceeding&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Pneumonia%2C+aseptic+meningitis%2C+and+leukopenia+in+a+28-year-old+man.&rft.au=Mathisen%2C+G+E%3BWeiss%2C+P+J%3BKennedy%2C+C+A&rft.aulast=Mathisen&rft.aufirst=G&rft.date=1993-06-01&rft.volume=16&rft.issue=6&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-17 N1 - Date created - 1993-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of morning or bedtime insulin with and without glyburide in secondary sulfonylurea failure. AN - 75841492; 8325203 AB - New treatment options are needed for glycemic control in NIDDM. We evaluated the effects of bedtime or morning insulin treatment, combined with daytime glyburide or given alone. Twenty-nine male patients with NIDDM, mean age 63 +/- 1.7 yr, body weight 124 +/- 2.98% of DBW, received a maximum glyburide dose (20 mg/day) for a minimum of 6 wk, to confirm sulfonylurea failure. Human lente insulin was added for 12 wk either AM (n = 14) or HS (n = 15) and adjusted to obtain fasting euglycemia (FPG; combination treatment phase). Glyburide was then stopped, and insulin was continued for 6 wk, aiming for normal FPG (insulin phase). After combination treatment phase, FPG decreased (P < 0.02) from 12.43 +/- 0.68 to 5.73 +/- 0.65 mM (AM) and from 12.68 +/- 0.76 to 5.51 +/- 0.48 mM (HS) (AM vs. HS, NS). Postbreakfast, presupper, and 0200 AM plasma glucose levels fell equally (P < 0.02) except for 1-h postprandial (AM 12.46 +/- 0.51 mM, HS 10.88 +/- 0.62 mM, AM vs. HS, P < 0.1). Mean HBA1c fell similarly in both AM and HS groups. At 2 wk of the insulin phase, FPG was higher in AM than HS, 9.8 +/- 0.76 vs. 7.56 +/- 0.7 mM (P < 0.1). At the end of insulin phase, plasma glucose levels were similar to the end of combination treatment phase, but the insulin dose had to be raised in AM by 39% (P < 0.02) and HS by 30% (P < 0.05). After the combination treatment phase, fasting C-peptide was significantly suppressed in HS group only, from 1.22 +/- 0.12 to 0.82 +/- 0.09 nM (P < 0.02). At the end of insulin phase, fasting C-peptide was further suppressed in both groups, but 2-h postprandial C-peptide levels decreased significantly in AM group only, from 1.85 +/- 0.23 to 1.42 +/- 0.13 nM (P < 0.02). Triglycerides and total and HDL cholesterol did not change significantly after either combination treatment phase or insulin phase. Mean weight gain was 6.5 lb during combination treatment phase (NS from baseline), without further change during insulin phase. Hypoglycemic reactions, all mild, were recorded at a rate of 1.35/patient in the AM group and 0.4/patient in the HS group (P < 0.025). Normal fasting glycemia and near-normal postprandial glucose profile could be obtained with combination therapy in NIDDM. Results were similar if insulin, alone or in combination with glyburide, was given before breakfast or at bedtime, but hypoglycemic reactions were more common with conventional morning insulin injections. JF - Diabetes care AU - Soneru, I L AU - Agrawal, L AU - Murphy, J C AU - Lawrence, A M AU - Abraira, C AD - Diabetes Research Laboratory, Hines Veterans Administration Hospital, Illinois 60141. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 896 EP - 901 VL - 16 IS - 6 SN - 0149-5992, 0149-5992 KW - Blood Glucose KW - 0 KW - C-Peptide KW - Hemoglobin A, Glycosylated KW - Insulin, Long-Acting KW - Recombinant Proteins KW - Glyburide KW - SX6K58TVWC KW - Index Medicus KW - Drug Administration Schedule KW - Hemoglobin A, Glycosylated -- analysis KW - C-Peptide -- blood KW - Humans KW - Aged KW - Fasting KW - Hypoglycemia -- chemically induced KW - Drug Therapy, Combination KW - Adult KW - Middle Aged KW - Time Factors KW - Recombinant Proteins -- therapeutic use KW - Male KW - Recombinant Proteins -- administration & dosage KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Insulin, Long-Acting -- administration & dosage KW - Glyburide -- adverse effects KW - Blood Glucose -- metabolism KW - Glyburide -- therapeutic use KW - Diabetes Mellitus, Type 2 -- blood KW - Insulin, Long-Acting -- therapeutic use KW - Insulin, Long-Acting -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75841492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Comparison+of+morning+or+bedtime+insulin+with+and+without+glyburide+in+secondary+sulfonylurea+failure.&rft.au=Soneru%2C+I+L%3BAgrawal%2C+L%3BMurphy%2C+J+C%3BLawrence%2C+A+M%3BAbraira%2C+C&rft.aulast=Soneru&rft.aufirst=I&rft.date=1993-06-01&rft.volume=16&rft.issue=6&rft.spage=896&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-06 N1 - Date created - 1993-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acidic and basic fibroblast growth factor mRNAs are increased in striatum following MPTP-induced dopamine neurofiber lesion: assay by quantitative PCR. AN - 75837332; 7686995 AB - Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF), the two best characterized members of a growing family of heparin-binding growth factors, have been shown to affect both survival of cultured neurons and regeneration of nerve terminals when applied exogenously. The endogenous expression of these growth factors in response to brain injury is not well understood. We have utilized the Swiss-Webster mouse, treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and a quantitative polymerase chain reaction assay to examine changes in endogenous synthesis of mRNA for both aFGF and bFGF in the striatum and substantia nigra. We have found that MPTP treatment results in a loss of 95% of dopaminergic function and is accompanied by an increase in expression of both aFGF and bFGF in the striatum at 1 week post-lesion. After 5 weeks, the terminals appear to be regenerating and FGF mRNA expression has returned to control levels. These results suggest that cellular reaction to chemical lesion in the brain may involve changes in growth factor expression, including both aFGF and bFGF. JF - Brain research. Molecular brain research AU - Leonard, S AU - Luthman, D AU - Logel, J AU - Luthman, J AU - Antle, C AU - Freedman, R AU - Hoffer, B AD - Denver Veterans Administration Medical Center, CO. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 275 EP - 284 VL - 18 IS - 4 SN - 0169-328X, 0169-328X KW - RNA, Messenger KW - 0 KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Fibroblast Growth Factor 1 KW - 104781-85-3 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Substantia Nigra -- metabolism KW - Polymerase Chain Reaction KW - Nerve Fibers -- drug effects KW - Animals KW - Base Sequence KW - Molecular Sequence Data KW - Mice KW - Immunohistochemistry KW - Corpus Striatum -- metabolism KW - RNA, Messenger -- drug effects KW - Fibroblast Growth Factor 2 -- genetics KW - Dopamine -- physiology KW - Corpus Striatum -- drug effects KW - RNA, Messenger -- biosynthesis KW - Fibroblast Growth Factor 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75837332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Molecular+brain+research&rft.atitle=Acidic+and+basic+fibroblast+growth+factor+mRNAs+are+increased+in+striatum+following+MPTP-induced+dopamine+neurofiber+lesion%3A+assay+by+quantitative+PCR.&rft.au=Leonard%2C+S%3BLuthman%2C+D%3BLogel%2C+J%3BLuthman%2C+J%3BAntle%2C+C%3BFreedman%2C+R%3BHoffer%2C+B&rft.aulast=Leonard&rft.aufirst=S&rft.date=1993-06-01&rft.volume=18&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Molecular+brain+research&rft.issn=0169328X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. AN - 75770709; 8509575 AB - Patients with latex sensitivity and latex antigens from the United States and Finland, two countries where allergic reactions to latex have been widely reported, were evaluated to determine the spectrum of immune responses. Sera from 27 patients from Finland and 18 from the United States with latex allergy and control sera from nonsensitive individuals were studied for latex-specific IgE antibodies. Four antigen preparations were used: two extracted from gloves and one each extracted from rubber tree sap from Malaysia and India. All 45 patients had skin prick test results that were positive to latex antigens, and all sera were evaluated by enzyme-linked immunosorbent assay (ELISA) with the various antigens. There were considerable differences in the reactivity of patient sera with the different antigens. Only 50% of the sera from patients with latex allergy from Finland demonstrated significant levels of IgE to latex as determined by enzyme-linked immunosorbent assay. These patients showed more reactivity with rubber tree sap antigens than with glove antigens. However, 72% of the patients from the United States demonstrated antibodies to latex, and no marked differences were noted between the antigen extracts. The results indicate that reagents such as rubber tree sap, which contain multiple clinically significant antigenic components, should be included in evaluation of latex allergy and that differences in patient populations may result in serologic variances. JF - The Journal of allergy and clinical immunology AU - Kurup, V P AU - Kelly, K J AU - Turjanmaa, K AU - Alenius, H AU - Reunala, T AU - Palosuo, T AU - Fink, J N AD - Zablocki Veterans Administration Medical Center, Department of Medicine, Medical College of Wisconsin, Milwaukee 53295-1000. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 1128 EP - 1134 VL - 91 IS - 6 SN - 0091-6749, 0091-6749 KW - Antigens KW - 0 KW - Latex KW - Immunoglobulin E KW - 37341-29-0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Finland KW - Skin Tests KW - Humans KW - Adult KW - Middle Aged KW - Anaphylaxis -- immunology KW - Male KW - Female KW - Latex -- adverse effects KW - Dermatitis, Allergic Contact -- immunology KW - Hypersensitivity, Immediate -- immunology KW - Immunoglobulin E -- blood KW - Antigens -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75770709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Immunoglobulin+E+reactivity+to+latex+antigens+in+the+sera+of+patients+from+Finland+and+the+United+States.&rft.au=Kurup%2C+V+P%3BKelly%2C+K+J%3BTurjanmaa%2C+K%3BAlenius%2C+H%3BReunala%2C+T%3BPalosuo%2C+T%3BFink%2C+J+N&rft.aulast=Kurup&rft.aufirst=V&rft.date=1993-06-01&rft.volume=91&rft.issue=6&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-09 N1 - Date created - 1993-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thalamic infarction secondary to cervical manipulation. AN - 85223560; pmid-8489368 AB - Vertebrobasilar infarction is a well documented complication of cervical manipulation. A commonly proposed pathogenesis is an intimal tear of the vertebral artery leading to cerebellar and other posterior fossa lesions. However, there have been no cases of thalamic infarct reported. This case demonstrates a thalamic infarction concurrent with brainstem and cerebellar infarction secondary to cervical manipulation and intimal tearing of the vertebral artery. Immediately following manipulation, the patient developed nystagmus, quadriparesis, and a speech deficit. After an aggressive course of in-patient rehabilitation, the patient progressed to a community ambulator with deficits in speech and perception. This case demonstrates one of the inherent risks associated with repetitive forceful cervical manipulation. JF - Archives of Physical Medicine and Rehabilitation AU - Sinel, M AU - Smith, D AD - Department of Physical Medicine and Rehabilitation, Veterans Administration Medical Center, West Los Angeles, CA. PY - 1993 SP - 543 EP - 546 VL - 74 IS - 5 SN - 0003-9993, 0003-9993 KW - Magnetic Resonance Imaging KW - Cerebral Infarction KW - Human KW - Thalamic Diseases KW - Adult KW - Manipulation, Orthopedic KW - Vertebral Artery KW - Tomography, X-Ray Computed KW - Case Report KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Thalamic+infarction+secondary+to+cervical+manipulation.&rft.au=Sinel%2C+M%3BSmith%2C+D&rft.aulast=Sinel&rft.aufirst=M&rft.date=1993-05-01&rft.volume=74&rft.issue=5&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Quinolone therapy in intensive care unit settings. AN - 76306426; 7922402 AB - Three fluoroquinolone antimicrobials (norfloxacin, ciprofloxacin, and ofloxacin) could be used to prevent or treat infections in intensive care unit patients. All of these fluoroquinolones are particularly active against Gram-negative, aerobic bacteria. However, the pharmacokinetic properties of each fluoroquinolone are unique. Furthermore, only ciprofloxacin and ofloxacin are available for intravenous administration. Based on current, available information: a) fluoroquinolones are not endorsed for inclusion in selective decontamination protocols; b) fluoroquinolones are endorsed for empiric therapy of suspected Gram-negative bacterial infections based on local microorganism susceptibility patterns; and c) fluoroquinolones are endorsed for treatment of microbiologically documented infections based on their distribution properties, low rate of toxicity, and rapid bactericidal effect. JF - New horizons (Baltimore, Md.) AU - Beam, T R AD - Buffalo Veterans Administration Medical Center, State University of New York at Buffalo 14215. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 187 EP - 193 VL - 1 IS - 2 SN - 1063-7389, 1063-7389 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Ofloxacin KW - A4P49JAZ9H KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Administration, Oral KW - Drug Interactions KW - Infusions, Intravenous KW - Humans KW - Drug Resistance, Microbial KW - Clinical Trials as Topic KW - Aged KW - Tissue Distribution KW - Microbial Sensitivity Tests KW - Male KW - Clinical Protocols KW - Ofloxacin -- supply & distribution KW - Norfloxacin -- pharmacokinetics KW - Ciprofloxacin -- pharmacokinetics KW - Intensive Care Units KW - Gram-Negative Bacterial Infections -- drug therapy KW - Ciprofloxacin -- therapeutic use KW - Norfloxacin -- supply & distribution KW - Gram-Negative Bacterial Infections -- microbiology KW - Cross Infection -- microbiology KW - Cross Infection -- drug therapy KW - Norfloxacin -- therapeutic use KW - Ofloxacin -- therapeutic use KW - Ciprofloxacin -- supply & distribution KW - Ofloxacin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76306426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+horizons+%28Baltimore%2C+Md.%29&rft.atitle=Quinolone+therapy+in+intensive+care+unit+settings.&rft.au=Beam%2C+T+R&rft.aulast=Beam&rft.aufirst=T&rft.date=1993-05-01&rft.volume=1&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=New+horizons+%28Baltimore%2C+Md.%29&rft.issn=10637389&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-25 N1 - Date created - 1994-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of condom use among intravenous drug users. AN - 75809424; 8318179 AB - To examine the factors associated with condom use among a cohort of sexually active intravenous drug users (IVDU). Data were collected via personal interview at the fourth-month assessment point of a longitudinal study monitoring HIV infection and risk behaviors among IVDU. A community-based methadone clinic. A total of 158 sexually active heterosexual male and female IVDU, including both methadone patients and out-of-treatment individuals with a history of opiate abuse. We describe a new approach to identify the determinants of condom use. Previous studies have described subjects as either 'condom users' or 'condom non-users', using an individual's overall behavior as the unit of analysis. By analyzing condom use during the most recent sexual encounter, we avoided the problem of interpreting inconsistent condom use. Data were analyzed using forward stepwise logistic regression. Thirty-four per cent of the heterosexual subjects (n = 160) reported using a condom during their last sexual encounter. Being HIV-positive and having either a causal or commercial partner were each associated with increased probability of using a condom (odds ratio, 10.6, 4.4 and 12.1, respectively). No interactions with sex were found. Our results suggest that knowing that one is HIV-positive is an important determinant of condom use; HIV testing may therefore increase the use of condoms. In addition, interventions to change sexual behaviors may need to focus on the type of sexual partner. JF - AIDS (London, England) AU - Watkins, K E AU - Metzger, D AU - Woody, G AU - McLellan, A T AD - University of Pennsylvania/Veterans Administration Medical Center, Philadelphia. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 719 EP - 723 VL - 7 IS - 5 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - Population KW - AIDS/HIV KW - United States KW - Barrier Methods KW - Research Methodology KW - Contraceptive Usage--determinants KW - Sex Behavior KW - Contraceptive Methods KW - Developed Countries KW - Hiv Infections KW - Data Collection KW - Diseases KW - Family Planning KW - Iv Drug Users KW - North America KW - Americas KW - Research Report KW - Knowledge KW - Condom KW - Northern America KW - Contraception KW - Behavior KW - Viral Diseases KW - Risk Factors KW - Interviews KW - Pennsylvania KW - Drug Usage KW - Biology KW - Sexual Behavior KW - Risk-Taking KW - HIV Infections -- transmission KW - HIV Infections -- complications KW - Humans KW - HIV Infections -- prevention & control KW - Cohort Studies KW - Adult KW - Philadelphia -- epidemiology KW - Male KW - Female KW - Sexual Partners KW - Condoms -- utilization KW - Substance Abuse, Intravenous -- complications KW - Substance Abuse, Intravenous -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75809424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Determinants+of+condom+use+among+intravenous+drug+users.&rft.au=Watkins%2C+K+E%3BMetzger%2C+D%3BWoody%2C+G%3BMcLellan%2C+A+T&rft.aulast=Watkins&rft.aufirst=K&rft.date=1993-05-01&rft.volume=7&rft.issue=5&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-05 N1 - Date created - 1993-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Theophylline in the ambulatory treatment of chronic obstructive lung disease: resolving a controversy. AN - 75785021; 8513541 AB - Recent reports of a high frequency of theophylline toxicity, which usually occurs at theophylline blood levels > 20 micrograms/mL, coupled with the recent addition of metered-dose, inhaled anticholinergics to the beta-2 agonist inhalers already available for treatment of chronic obstructive pulmonary disease, has led some authors to suggest that theophylline should no longer be used in the ambulatory management of this disease. The author suggests an alternate approach to theophylline dosing as a means of resolving the current controversy. Because of the log-linear relationship between bronchodilation and blood level, little bronchodilator efficacy is lost by using a target therapeutic theophylline blood level of 10 +/- 2 micrograms/mL. This target provides a greater range between therapeutic and toxic blood levels than the 17 +/- 2 micrograms/mL therapeutic target blood level that has also been recommended. Because theophylline has a different mode of action than the sympathomimetic or anticholinergic drugs, it continues to have a useful place in the ambulatory management of chronic obstructive pulmonary disease. JF - Cleveland Clinic journal of medicine AU - Snider, G L AD - Boston Veterans Administration Medical Center, MA 01230. PY - 1993 SP - 197 EP - 201 VL - 60 IS - 3 SN - 0891-1150, 0891-1150 KW - Bronchodilator Agents KW - 0 KW - Theophylline KW - C137DTR5RG KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Bronchodilator Agents -- therapeutic use KW - Ambulatory Care KW - Theophylline -- pharmacokinetics KW - Theophylline -- therapeutic use KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75785021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Theophylline+in+the+ambulatory+treatment+of+chronic+obstructive+lung+disease%3A+resolving+a+controversy.&rft.au=Snider%2C+G+L&rft.aulast=Snider&rft.aufirst=G&rft.date=1993-05-01&rft.volume=60&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=08911150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychosocial factors, alcohol use, and hangover signs among social drinkers: a reappraisal. AN - 75761989; 8501466 AB - To reappraise a prior study of hangover signs and psychosocial factors among a sample of current drinkers, we excluded a subgroup termed Sobers, who report "never" being "tipsy, high or drunk." The non-sober current drinkers then formed the sample for this report (N = 1104). About 23% of this group reported no hangover signs regardless of their intake level or gender, and the rest showed no sex differences for any of 8 hangover signs reported. Using multiple regression, including ethanol, age and weight, it was found that psychosocial variables contributed independently in predicting to hangover for both men and women in this order: (1) guilt about drinking; (2) neuroticism; (3) angry or (4) depressed when high/drunk and (5) negative life events. For men only, ethanol intake was also significant; for women only, being younger and reporting first being high/drunk at a relatively earlier age were also predictors of the Hangover Sign Index (HSI). These multiple predictors accounted for 5-10 times more of the hangover variance than alcohol use alone: for men, R = 0.43, R2 = 19%; and for women, R = 0.46, R2 = 21%. The findings suggest that hangover signs are a function of age, sex, ethanol level and psychosocial factors. JF - Journal of clinical epidemiology AU - Harburg, E AU - Gunn, R AU - Gleiberman, L AU - DiFranceisco, W AU - Schork, A AD - Department of Epidemiology, School of Public Health, Veterans Administration Hospital, Ann Arbor, MI. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 413 EP - 422 VL - 46 IS - 5 SN - 0895-4356, 0895-4356 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Severity of Illness Index KW - Body Weight KW - Regression Analysis KW - Ethanol -- blood KW - Age Factors KW - Sex Factors KW - Humans KW - Male KW - Female KW - Alcoholic Intoxication -- psychology KW - Alcohol Drinking -- psychology KW - Alcoholic Intoxication -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Psychosocial+factors%2C+alcohol+use%2C+and+hangover+signs+among+social+drinkers%3A+a+reappraisal.&rft.au=Harburg%2C+E%3BGunn%2C+R%3BGleiberman%2C+L%3BDiFranceisco%2C+W%3BSchork%2C+A&rft.aulast=Harburg&rft.aufirst=E&rft.date=1993-05-01&rft.volume=46&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-01 N1 - Date created - 1993-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 60 Hz magnetic field acts as co-promoter in focus formation of C3H/10T1/2 cells. AN - 75761829; 8504489 AB - Disruption of communication between transformed cells and normal cells is involved in tumor promotion. We have tested the hypothesis that 60 Hz electromagnetic (EM) field exposures and a chemical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) are co-promoters that enhance focus formation of transformed cells in co-culture with normal cells. EM field exposures alone did not affect the growth curves of parental C3H/10T1/2 fibroblasts or daughter mutant cells, UV-TDTx10e. Furthermore, EM field exposures alone did not promote focus formation of mutant cells in co-culture with parental cells under the conditions tested. However, EM field exposures co-promoted with TPA by increasing focus formation in co-culture. Cell cultures were exposed to an EM field in custom-built solenoidal incubators. The field exposures were 1.0 Gauss in a schedule of 1 h epochs four times daily for 28 days. Video image analysis of three independent experiments showed that field-exposed cultures produced 1.9-fold more foci than sham-exposed cultures when treated with TPA. The total area of foci per dish increased 2.2-fold and the number of cells in stained foci increased 2.3-fold. In a TPA dose-response, focus formation began at 3 ng/ml with no difference between field-exposed and sham-exposed co-cultures. However, at the TPA concentrations of 10, 20, 40, 50 and 100 ng/ml EM field exposures enhanced focus formation by an average of 150%. This study suggests that chronic intermittent exposures to a 60 Hz EM field and a chemical tumor promoter influenced membrane-related events by co-promoting focus formation. JF - Carcinogenesis AU - Cain, C D AU - Thomas, D L AU - Adey, W R AD - Jerry L. Pettis Memorial Veterans Administration Medical Center, Research Service, Loma Linda, CA 92357. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 955 EP - 960 VL - 14 IS - 5 SN - 0143-3334, 0143-3334 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Fibroblasts -- drug effects KW - Animals KW - Video Recording KW - Fibroblasts -- pathology KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Mice KW - Fibroblasts -- radiation effects KW - Cell Line KW - Tetradecanoylphorbol Acetate -- toxicity KW - Magnetics KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=60+Hz+magnetic+field+acts+as+co-promoter+in+focus+formation+of+C3H%2F10T1%2F2+cells.&rft.au=Cain%2C+C+D%3BThomas%2C+D+L%3BAdey%2C+W+R&rft.aulast=Cain&rft.aufirst=C&rft.date=1993-05-01&rft.volume=14&rft.issue=5&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-06 N1 - Date created - 1993-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of antihypertensive and beta 1-adrenoceptor antagonist effect of nebivolol and atenolol in essential hypertension. AN - 75730895; 8098243 AB - dl-nebivolol is a new, chemically unique, selective beta 1-adrenoceptor antagonist, without sympathomimetic activity. In the present study, the antihypertensive and negative chronotropic effects of 5 and 10 mg once-daily nebivolol were compared to those of 50 and 100 mg once-daily atenolol in 25 white, male subjects with essential hypertension, using a double-blind, crossover design, and a parallel placebo-treated group of subjects (N = 7). 24 hours after dosing, sitting and standing diastolic and systolic blood pressures and heart rates (at rest and during submaximal exercise) were reduced to the same extent by nebivolol and atenolol. On a weight-for-weight basis, nebivolol is ten times more potent than atenolol. Nebivolol and atenolol also reduced 1-hour ambulatory plasma renin activity. Once-daily nebivolol is an effective antihypertensive beta-adrenoceptor antagonist. JF - Clinical and experimental hypertension (New York, N.Y. : 1993) AU - Simon, G AU - Johnson, M L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 501 EP - 509 VL - 15 IS - 3 SN - 1064-1963, 1064-1963 KW - Adrenergic beta-Antagonists KW - 0 KW - Antihypertensive Agents KW - Benzopyrans KW - Ethanolamines KW - Nebivolol KW - 030Y90569U KW - Atenolol KW - 50VV3VW0TI KW - Renin KW - EC 3.4.23.15 KW - Index Medicus KW - Renin -- blood KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Ethanolamines -- therapeutic use KW - Hypertension -- physiopathology KW - Benzopyrans -- therapeutic use KW - Hypertension -- blood KW - Atenolol -- therapeutic use KW - Benzopyrans -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Ethanolamines -- adverse effects KW - Adrenergic beta-Antagonists -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75730895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.atitle=Comparison+of+antihypertensive+and+beta+1-adrenoceptor+antagonist+effect+of+nebivolol+and+atenolol+in+essential+hypertension.&rft.au=Simon%2C+G%3BJohnson%2C+M+L&rft.aulast=Simon&rft.aufirst=G&rft.date=1993-05-01&rft.volume=15&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.issn=10641963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-11 N1 - Date created - 1993-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dextromethorphan and its combination with phenytoin facilitate kindling. AN - 75728079; 8492958 AB - We implanted 20 rats with bipolar electrodes and randomly distributed them into four groups that received intraperitoneal injections of phenytoin (PHT) (20 mg/kg), dextromethorphan (DM) (50 mg/kg), PHT+DM (20 and 50 mg/kg, respectively), or saline (C), 15 minutes before each daily stimulation. The number of stimulations needed to reach stage 3 seizures was 14.4 +/- 1.7 (C); 28 +/- 12 (PHT, p < 0.001); 6.2 +/- 3.9 (DM, p < 0.05); and 7.6 +/- 3.4 (PHT+DM, p < 0.05), suggesting that DM accelerated the expression of kindled seizures. Daily injections of DM and of DM+PHT without stimulation resulted in progressive seizure buildup to stage 3 in 4.8 +/- 6.2 (DM) or in 8 +/- 4.8 (DM+PHT) trials. We demonstrated savings in six kindled animals reinjected after 1 month. These results and previous experimental and clinical data suggest that DM may be epileptogenic when given repeatedly in high doses. JF - Neurology AU - Thompson, K W AU - Wasterlain, C G AD - Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 992 EP - 994 VL - 43 IS - 5 SN - 0028-3878, 0028-3878 KW - Phenytoin KW - 6158TKW0C5 KW - Dextromethorphan KW - 7355X3ROTS KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Hippocampus -- physiology KW - Hippocampus -- physiopathology KW - Electric Stimulation KW - Male KW - Hippocampus -- drug effects KW - Seizures -- chemically induced KW - Phenytoin -- pharmacology KW - Kindling, Neurologic -- drug effects KW - Seizures -- physiopathology KW - Dextromethorphan -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75728079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Dextromethorphan+and+its+combination+with+phenytoin+facilitate+kindling.&rft.au=Thompson%2C+K+W%3BWasterlain%2C+C+G&rft.aulast=Thompson&rft.aufirst=K&rft.date=1993-05-01&rft.volume=43&rft.issue=5&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-11 N1 - Date created - 1993-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 1994 Mar;44(3 Pt 1):582-3 [8179707] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells. AN - 75723525; 8489251 AB - To examine the effects of hyperglycemia on insulin signaling in A-10 vascular smooth muscle cells, cells were treated with extracellular D-glucose and effects of insulin were studied on the diacylglycerol-protein kinase C signaling system. A-10 cells specifically bound 125I-insulin, and insulin-like growth factor-I did not displace the label. 125I-insulin binding was unaltered under hyperglycemic conditions. To determine if insulin receptors were coupled to other insulin-regulated processes, diacylglycerol, protein kinase C, and glucose transport were evaluated. Insulin increased cellular diacylglycerol (DAG) levels which were also increased following glucose treatment and not further stimulated by insulin. The uptake of 2-[3H]deoxy-D-glucose (2-DOG) was stimulated by insulin and 12-O-tetradecanoyl phorbol 13-acetate (TPA). Insulin- and TPA-stimulated 2-[3H]DOG uptake was inhibited by a protein kinase inhibitor, staurosporine. Preincubation of cells with 500 nM TPA overnight resulted in the inhibition of insulin- and TPA-stimulated 2-[3H]DOG uptake. Protein kinase C activity was translocated from cytosolic to membrane fractions following insulin treatment. Overnight glucose (25 mM) treatment resulted in a 50% decrease in protein kinase C enzyme activity and > 90% decrease in protein kinase C beta immunoreactive levels. Protein kinase C activity and levels were not affected by osmotic control media containing mannitol. A-10 cells express GLUT4-type glucose transporters. Neither insulin-regulatable glucose transporter (GLUT4) mRNA nor GLUT4 protein levels were diminished by glucose. Significant decreases in insulin- and TPA-stimulated 2-[3H]DOG uptake occurred, however, with glucose. The down-regulation of protein kinase C beta and resultant inhibition of 2-[3H]DOG uptake by chronic glucose suggests a biochemical link between hyperglycemia and DAG-protein kinase C signaling in vascular smooth muscle cells. JF - Archives of biochemistry and biophysics AU - Cooper, D R AU - Khalakdina, A AU - Watson, J E AD - Research Service, J. A. Haley Veterans Administration Hospital, Tampa, Florida 33612. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 490 EP - 498 VL - 302 IS - 2 SN - 0003-9861, 0003-9861 KW - Alkaloids KW - 0 KW - Diglycerides KW - Glucose Transporter Type 4 KW - Insulin KW - Monosaccharide Transport Proteins KW - Muscle Proteins KW - Slc2a4 protein, rat KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Staurosporine KW - H88EPA0A3N KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Hyperglycemia -- metabolism KW - Biological Transport KW - Membranes -- metabolism KW - Rats KW - Protein Kinase C -- antagonists & inhibitors KW - Down-Regulation KW - Cell Compartmentation KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Alkaloids -- pharmacology KW - Monosaccharide Transport Proteins -- analysis KW - Cell Line KW - Deoxyglucose -- metabolism KW - Diglycerides -- metabolism KW - Signal Transduction -- physiology KW - Glucose -- pharmacology KW - Glucose -- metabolism KW - Signal Transduction -- drug effects KW - Muscle, Smooth, Vascular -- drug effects KW - Insulin -- metabolism KW - Insulin -- pharmacology KW - Muscle, Smooth, Vascular -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75723525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Chronic+effects+of+glucose+on+insulin+signaling+in+A-10+vascular+smooth+muscle+cells.&rft.au=Cooper%2C+D+R%3BKhalakdina%2C+A%3BWatson%2C+J+E&rft.aulast=Cooper&rft.aufirst=D&rft.date=1993-05-01&rft.volume=302&rft.issue=2&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-04 N1 - Date created - 1993-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical Course of Alcoholism in 636 Male Inpatients AN - 61322906; 9404366 AB - The rate of & age of first occurrence of quantifiable symptoms of alcohol dependence are examined through structured interviews with 636 male alcoholic inpatients at a Veteran's Administration treatment program in San Diego, CA. Nearly 75% of the Ss began to display severe alcohol-related symptoms by their late 20s. In the early to mid-30s, more serious signs of alcohol's interference with life functioning appeared, eg, blackouts, alcohol withdrawal, & arrest for public intoxication or drunk driving. By the mid-30s, perception of loss of control occurred, accompanied by intensification of social & employment difficulties & deterioration of health. The late 30s to early 40s brought signs of serious long-term consequences of alcohol use & other difficulties. Similar patterns of alcohol dependence were found after controlling for age of onset, family history of alcoholism, & other psychiatric disorders. 2 Tables, 27 References. D. Generoli JF - The American Journal of Psychiatry AU - Schuckit, Marc A AU - Smith, Tom L AU - Anthenelli, Robert AU - Irwin, Michael AD - Dept Psychiatry Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 786 EP - 792 VL - 150 IS - 5 SN - 0002-953X, 0002-953X KW - alcoholism's clinical course, males KW - interview data KW - middle-aged inpatients, Veteran's Administration treatment program, San Diego, California KW - Symptoms KW - Males KW - Alcoholism KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61322906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Clinical+Course+of+Alcoholism+in+636+Male+Inpatients&rft.au=Schuckit%2C+Marc+A%3BSmith%2C+Tom+L%3BAnthenelli%2C+Robert%3BIrwin%2C+Michael&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1993-05-01&rft.volume=150&rft.issue=5&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Alcoholism; Males; Symptoms ER - TY - JOUR T1 - In-Hospital Respite as a Moderator of Caregiver Stress AN - 1761711338; 199401838 AB - Telephone survey data on family caregiver (N = 22) stress obtained 3 days before, during, & 14 days following respite (short-term patient stays in a hospital) suggest that stress was moderated by an in-hospital respite program for patients with Alzheimer's disease. Results indicate that, although short-term benefits may be realized for caregivers, in-hospital Alzheimer's respite care may present a particular risk for patient decline, adverse events, & institutionalization. 1 Table, 19 References. Adapted from the source document. JF - Health and Social Work AU - Larkin, John P AU - Hopcroft, Barbara Most AD - Social Work Services Veterans Administration Medical Center, Hampton VA 23667 Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 132 EP - 138 VL - 18 IS - 2 SN - 0360-7283, 0360-7283 KW - caregiver stress reduction, in-hospital respite care's effect, Alzheimer patients KW - Psychological Stress KW - Caregivers KW - Family Relations KW - Hospitalization KW - Treatment Programs KW - Alzheimer's Disease KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761711338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+and+Social+Work&rft.atitle=In-Hospital+Respite+as+a+Moderator+of+Caregiver+Stress&rft.au=Larkin%2C+John+P%3BHopcroft%2C+Barbara+Most&rft.aulast=Larkin&rft.aufirst=John&rft.date=1993-05-01&rft.volume=18&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Health+and+Social+Work&rft.issn=03607283&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Caregivers; Family Relations; Alzheimer's Disease; Treatment Programs; Hospitalization; Psychological Stress ER - TY - JOUR T1 - Rapid degradation of NAD by retinoic acid-differentiated HL-60 granulocyte membranes prevents ADP ribosylation. AN - 75715180; 8387292 AB - Pertussis and cholera toxins failed to ADP-ribosylate G alpha s and G alpha i in membranes isolated from retinoic acid-differentiated HL-60 granulocytes, although G alpha i subunits were present. NAD was rapidly degraded in the presence of these membranes, primarily to ADP-ribose, to less than 10% of initial activity by 5 min. Metabolism of NAD was heat labile and inhibited by NADP, but not by imidazole or isonicotinic acid hydrazine. Pertussis toxin uncoupled LTB4 receptors from G proteins in intact retinoic acid-differentiated HL-60 cells. Retinoic acid differentiation stimulates expression of a unique NAD-glycohydrolase activity in HL-60 granulocytes which prevents ADP-ribosylation in isolated membranes, but not intact cells. JF - Biochemical and biophysical research communications AU - McLeish, K R AU - Jacobs, A A AD - Veterans Administration Medical Center, Louisville, KY. Y1 - 1993/04/30/ PY - 1993 DA - 1993 Apr 30 SP - 870 EP - 878 VL - 192 IS - 2 SN - 0006-291X, 0006-291X KW - Virulence Factors, Bordetella KW - 0 KW - NAD KW - 0U46U6E8UK KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Tretinoin KW - 5688UTC01R KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - NAD+ Nucleosidase KW - EC 3.2.2.5 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Virulence Factors, Bordetella -- pharmacology KW - Tretinoin -- pharmacology KW - NAD+ Nucleosidase -- metabolism KW - Cells, Cultured KW - Cell Membrane -- drug effects KW - Humans KW - GTP-Binding Proteins -- metabolism KW - Cholera Toxin -- pharmacology KW - Cell Membrane -- metabolism KW - Cell Differentiation -- drug effects KW - NAD -- metabolism KW - Granulocytes -- metabolism KW - Granulocytes -- drug effects KW - Adenosine Diphosphate Ribose -- metabolism KW - Granulocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75715180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Rapid+degradation+of+NAD+by+retinoic+acid-differentiated+HL-60+granulocyte+membranes+prevents+ADP+ribosylation.&rft.au=McLeish%2C+K+R%3BJacobs%2C+A+A&rft.aulast=McLeish&rft.aufirst=K&rft.date=1993-04-30&rft.volume=192&rft.issue=2&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-01 N1 - Date created - 1993-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy. AN - 75643893; 8463294 AB - Considerable effort is being made to design anti-viral drugs for the human immunodeficiency virus type 1 (HIV-1) infection process. Some of this work has focused on CD4 protein, the HIV-1 receptor on T helper lymphocytes. One drug that binds to CD4 protein and inhibits both viral infection and growth is DIDS (4,4'-diisothiocyanato-2,2'-stilbenedisulfonate). DIDS is best known for its ability to inhibit erythrocyte band 3 anion exchange. Although the antiviral potency of DIDS is evident in vitro (IC50 approximately 30 microM), intravenous administration of DIDS should not be effective owing to the large number of band 3 molecules present on the red blood cell membrane (approximately 10(6)/cell), and to the very small Kd for DIDS binding to band 3 (approximately 30 nM). Therefore, we sought to identify other anion transport inhibitors that would bind weakly to band 3, but tightly to CD4 protein, and that could be administered to humans without significant toxic side effects. On the basis of our previous work with band 3 (Salhany, J. M., Rauenbuehler, P. B., and Sloan, R. L. (1987) J. Biol. Chem. 262, 15965-15973), we elected to study the binding of pyridoxal 5'-phosphate (PLP) to soluble CD4 protein. We have discovered that PLP binds surprisingly tightly to soluble CD4 protein (Kd = 45 microM), with a stoichiometry of about 1 mol of PLP/mol of protein. Furthermore, PLP binding was found to be competitive with DIDS for its binding site on soluble CD4 protein. These results suggest that PLP may be an effective anti-viral agent for the HIV-1 infection process. JF - The Journal of biological chemistry AU - Salhany, J M AU - Schopfer, L M AD - Veterans Administration Medical Center, Omaha, Nebraska. Y1 - 1993/04/15/ PY - 1993 DA - 1993 Apr 15 SP - 7643 EP - 7645 VL - 268 IS - 11 SN - 0021-9258, 0021-9258 KW - Antigens, CD4 KW - 0 KW - Recombinant Proteins KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid KW - 27816-59-7 KW - Pyridoxal Phosphate KW - 5V5IOJ8338 KW - 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid KW - Q1O6DSW23R KW - Index Medicus KW - AIDS/HIV KW - Recombinant Proteins -- isolation & purification KW - Animals KW - Spectrometry, Fluorescence KW - Transfection KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Humans KW - CHO Cells KW - Spectrophotometry KW - Protein Binding KW - Cricetinae KW - HIV-1 -- metabolism KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid -- metabolism KW - Antigens, CD4 -- isolation & purification KW - Antigens, CD4 -- genetics KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid -- analogs & derivatives KW - Pyridoxal Phosphate -- metabolism KW - Antigens, CD4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75643893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pyridoxal+5%27-phosphate+binds+specifically+to+soluble+CD4+protein%2C+the+HIV-1+receptor.+Implications+for+AIDS+therapy.&rft.au=Salhany%2C+J+M%3BSchopfer%2C+L+M&rft.aulast=Salhany&rft.aufirst=J&rft.date=1993-04-15&rft.volume=268&rft.issue=11&rft.spage=7643&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-06 N1 - Date created - 1993-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of human pancreatic cancer cell-induced hepatic metastasis in nude mice by dipyridamole and its analog RA-233. AN - 75632671; 8453569 AB - Several studies have provided evidence suggesting that platelets play a key role in tumor metastasis. A number of antiplatelet agents have been used to prevent tumor metastasis in animal models and humans. Antiplatelet agents, dipyridamole (adenosine transport inhibitor), and RA-233 (inhibitor of cAMP PDE) were used to prevent tumor-cell-platelet interactions both in in vitro and in vivo systems; however, the data were not very conclusive. Our studies used dipyridamole and RA-233 alone and in combination to investigate their effects on human pancreatic tumor cells (RWP-2)-induced platelet aggregation in human blood and on hepatic metastasis in nude mice. To examine effects of dipyridamole and RA-233 on liver metastasis, the tumor cells (RWP-2) were injected intrasplenically in nude mice grouped into control, dipyridamole (8 mg/kg), RA-233 (8 mg/kg), and dipyridamole plus RA-233 (8 mg/kg each). The agents were administered intraperitoneally 1 hour before and 24 hours after the tumor cell injection. When dipyridamole and RA-233 were used alone, only weak to moderate effects were seen on RWP-2 tumor cell-induced platelet aggregation. However, these agents, when combined, strongly inhibited the tumor cell-induced aggregation in human platelet-rich plasma. In tumor metastasis experiments, reductions of approximately 70% in hepatic nodules and 90% in surface area occupied by the tumor were seen with the combination treatment (dipyridamole plus RA-233) as compared with the control group of mice. This study suggests that the combination of dipyridamole and RA-233 provides an effective intervention for the antithrombotic approach to the treatment of cancer metastases. JF - Cancer AU - Tzanakakis, G N AU - Agarwal, K C AU - Vezeridis, M P AD - Surgical Service Veterans Administration Medical Center, Providence, Rhode Island. Y1 - 1993/04/15/ PY - 1993 DA - 1993 Apr 15 SP - 2466 EP - 2471 VL - 71 IS - 8 SN - 0008-543X, 0008-543X KW - Mopidamol KW - 4Q0IWP8B8O KW - Dipyridamole KW - 64ALC7F90C KW - Adenosine KW - K72T3FS567 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Animals KW - Tumor Cells, Cultured KW - Adenosine -- blood KW - Humans KW - Mice, Nude KW - Mice KW - Drug Synergism KW - Liver Neoplasms -- prevention & control KW - Pancreatic Neoplasms -- blood KW - Mopidamol -- pharmacology KW - Liver Neoplasms -- secondary KW - Dipyridamole -- pharmacology KW - Platelet Aggregation -- drug effects KW - Liver Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75632671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Prevention+of+human+pancreatic+cancer+cell-induced+hepatic+metastasis+in+nude+mice+by+dipyridamole+and+its+analog+RA-233.&rft.au=Tzanakakis%2C+G+N%3BAgarwal%2C+K+C%3BVezeridis%2C+M+P&rft.aulast=Tzanakakis&rft.aufirst=G&rft.date=1993-04-15&rft.volume=71&rft.issue=8&rft.spage=2466&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-22 N1 - Date created - 1993-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Auditory sensory gating in the rat hippocampus: modulation by brainstem activity. AN - 85230179; pmid-8481808 AB - Auditory stimuli repeated at short intervals result in diminished evoked responses recorded from the skull surface and from the hippocampus in the rat. The rat has been used to model diminished responses to repeated auditory stimuli--a phenomenon seen in normal human subjects, but often absent in schizophrenics. In this study, we examined the neural circuitry involved in the processing and gating of auditory responses recorded from the hippocampus of the rat. Evoked potentials and single neuron activity with diminished responses to the second of paired tones were recorded in the brainstem reticular formation in the paragigantocellular region at the caudal level of the pons, but diminished responses were not observed in the primary auditory relay nuclei. Electrical stimulation of this region of the brainstem reticular formation was able to substitute for the first, or conditioning, auditory tone to produce sensory gating of the response to the second, or test, tone when recording from the hippocampus. Stimulation of the auditory nuclei up to the level of the lateral lemniscus, but not the superior colliculus, was also able to substitute for an auditory stimulus to produce sensory gating in the hippocampus. The gating of hippocampal responses to auditory stimuli may thus involve pathways which branch from the lemniscal auditory pathway at the level of the lateral lemniscus and ascend to the hippocampus via the brainstem reticular formation. JF - Brain Research AU - Bickford, P C AU - Luntz-Leybman, V AU - Freedman, R AD - Veterans Administration Medical Center, Denver, CO 80220. PY - 1993 SP - 33 EP - 38 VL - 607 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Rats KW - Rats, Sprague-Dawley KW - Conditioning (Psychology) KW - Evoked Potentials, Auditory, Brain Stem KW - Hippocampus KW - Animal KW - Brain Stem KW - Acoustic Stimulation KW - Histocytochemistry KW - Electric Stimulation KW - Reticular Formation KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Auditory+sensory+gating+in+the+rat+hippocampus%3A+modulation+by+brainstem+activity.&rft.au=Bickford%2C+P+C%3BLuntz-Leybman%2C+V%3BFreedman%2C+R&rft.aulast=Bickford&rft.aufirst=P&rft.date=1993-04-01&rft.volume=607&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Significance of tumor thickness in soft palate carcinoma. AN - 85196852; pmid-8459747 AB - Tumor thickness is an important prognostic factor in tumors outside of the upper aerodigestive tract, such as cutaneous melanoma, colorectal carcinoma, and cervical carcinoma. Some studies have also suggested that tumor thickness may have similar prognostic value in the upper aerodigestive tract. This study examined the relationship between tumor thickness (measured with an ocular micrometer) and nodal disease and that between tumor thickness and survival in 44 patients with soft palate epidermoid carcinoma. There was a significant correlation between tumor thickness and nodal disease. None of the 24 lesions less than or equal to 2.86 mm had cervical adenopathy. All of the 15 lesions greater than or equal to 3.12 mm had palpable adenopathy. Tumor thickness correlated more directly with nodal disease than did T stage. Thicker lesions were associated with poorer survival. Tumor thickness is an important parameter in the head and neck and deserves further study. JF - The Laryngoscope AU - Baredes, S AU - Leeman, D J AU - Chen, T S AU - Mohit-Tabatabai, M A AD - Veterans Administration Medical Center, East Orange, NJ. PY - 1993 SP - 389 EP - 393 VL - 103 IS - 4 Pt 1 SN - 0023-852X, 0023-852X KW - Neoplasm Staging KW - Combined Modality Therapy KW - Lymphatic Metastasis KW - Human KW - Retrospective Studies KW - Aged KW - Palate, Soft KW - Neck KW - Survival Rate KW - Adult KW - Middle Age KW - Follow-Up Studies KW - Neoplasm Recurrence, Local KW - Lymph Node Excision KW - Carcinoma, Squamous Cell KW - Male KW - Palatal Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85196852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Significance+of+tumor+thickness+in+soft+palate+carcinoma.&rft.au=Baredes%2C+S%3BLeeman%2C+D+J%3BChen%2C+T+S%3BMohit-Tabatabai%2C+M+A&rft.aulast=Baredes&rft.aufirst=S&rft.date=1993-04-01&rft.volume=103&rft.issue=4+Pt+1&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Hypertension secondary to chlorpropamide with amelioration by changing to insulin. AN - 75809182; 8507452 AB - A retrospective analysis of the records of 22 type II diabetics whose treatment had been changed from insulin to chlorpropamide was performed to investigate the relative effects of insulin and chlorpropamide on blood pressure. Although diastolic BP index was not significantly different between the treatments, systolic BP index was significantly higher on chlorpropamide than on insulin (141 +/- 3 v 135 +/- 3 mm Hg, P = .02). In 10 patients in whom insulin was reinstituted, systolic BP fell significantly (P < .005), suggesting that in type II diabetics chlorpropamide exerts a relative hypertensive effect in comparison to insulin. JF - American journal of hypertension AU - Schmitt, J K AU - Moore, J R AD - Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 317 EP - 319 VL - 6 IS - 4 SN - 0895-7061, 0895-7061 KW - Insulin KW - 0 KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - Databases, Bibliographic KW - Blood Pressure KW - Blood Pressure Determination -- methods KW - Humans KW - Retrospective Studies KW - Middle Aged KW - Male KW - Female KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Chlorpropamide -- adverse effects KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Insulin -- therapeutic use KW - Chlorpropamide -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75809182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Hypertension+secondary+to+chlorpropamide+with+amelioration+by+changing+to+insulin.&rft.au=Schmitt%2C+J+K%3BMoore%2C+J+R&rft.aulast=Schmitt&rft.aufirst=J&rft.date=1993-04-01&rft.volume=6&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-14 N1 - Date created - 1993-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the efficacy and safety of ceftibuten and cefaclor in the treatment of pneumonia and bronchiectasis. AN - 75796463; 8515295 AB - In a multicentre, international study of 187 adult patients with bacterial pneumonia or bronchiectasis, the safety and efficacy of a regimen of 200 mg ceftibuten administered twice-daily was compared with cefaclor given in a dosage of 500 mg three times a day. Of the 94 evaluable patients, 66 received ceftibuten and 28 received cefaclor. The overall bacteriological response was similar in the two treatment groups with elimination of the original pathogen in 91% and 89% of the patients receiving ceftibuten and cefaclor, respectively. The overall clinical response mirrored the bacteriological results with a successful clinical outcome in 92% of ceftibuten-treated patients compared with 93% in patients receiving cefaclor. Adverse experiences were, in general, few and mild, being reported in 8% and 17% of patients receiving ceftibuten and cefaclor, respectively. JF - Journal of chemotherapy (Florence, Italy) AU - McCabe, R AU - Rumans, L AU - Perrotta, R AU - Mogabgab, W AD - Veterans Administration Medical Center, Martinez, CA 94553. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 124 EP - 132 VL - 5 IS - 2 SN - 1120-009X, 1120-009X KW - Cephalosporins KW - 0 KW - Cefaclor KW - 69K7K19H4L KW - ceftibuten KW - IW71N46B4Y KW - Index Medicus KW - Humans KW - Adult KW - Bacteria -- drug effects KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Pneumonia -- microbiology KW - Cefaclor -- therapeutic use KW - Cephalosporins -- therapeutic use KW - Pneumonia -- drug therapy KW - Cefaclor -- adverse effects KW - Bronchiectasis -- microbiology KW - Bacterial Infections -- drug therapy KW - Bronchiectasis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75796463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.atitle=Comparison+of+the+efficacy+and+safety+of+ceftibuten+and+cefaclor+in+the+treatment+of+pneumonia+and+bronchiectasis.&rft.au=McCabe%2C+R%3BRumans%2C+L%3BPerrotta%2C+R%3BMogabgab%2C+W&rft.aulast=McCabe&rft.aufirst=R&rft.date=1993-04-01&rft.volume=5&rft.issue=2&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.issn=1120009X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaesthetic properties of dimethylthiourea. AN - 75752418; 8499210 AB - We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. Dimethylthiourea 0.5 g kg-1 decreased isoflurane MAC by 23%; at a dose of 2.0-4.0 g kg-1, it abolished the response to tail clamp. Doses of 4.0 g kg-1 were lethal in the presence of isoflurane. A serum concentration of dimethylthiourea approximately 1 mg ml-1 produced a 50% reduction in isoflurane MAC. These anaesthetic properties of dimethylthiourea may influence experimental studies that examine the biochemical and physiological properties of this agent. JF - British journal of anaesthesia AU - Koblin, D D AU - Laster, M J AU - Liu, J AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 456 EP - 458 VL - 70 IS - 4 SN - 0007-0912, 0007-0912 KW - 1,3-dimethylthiourea KW - 8P30PMD17W KW - Isoflurane KW - CYS9AKD70P KW - Thiourea KW - GYV9AM2QAG KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Mice, Inbred ICR KW - Reflex -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Posture -- physiology KW - Drug Synergism KW - Male KW - Movement -- drug effects KW - Anesthesia, General KW - Thiourea -- analogs & derivatives KW - Thiourea -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75752418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+anaesthesia&rft.atitle=Anaesthetic+properties+of+dimethylthiourea.&rft.au=Koblin%2C+D+D%3BLaster%2C+M+J%3BLiu%2C+J&rft.aulast=Koblin&rft.aufirst=D&rft.date=1993-04-01&rft.volume=70&rft.issue=4&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=British+journal+of+anaesthesia&rft.issn=00070912&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-01 N1 - Date created - 1993-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Review article: lack of clinical significance of the interaction between H2-receptor antagonists and ethanol. AN - 75741359; 8097933 AB - It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2-receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2-antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2-antagonists and ethanol is clinically insignificant. JF - Alimentary pharmacology & therapeutics AU - Levitt, M D AD - Minneapolis Veterans Administration Medical Center, MN 55417. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 131 EP - 138 VL - 7 IS - 2 SN - 0269-2813, 0269-2813 KW - Histamine H2 Antagonists KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Drug Interactions KW - Humans KW - Gastric Mucosa -- metabolism KW - Histamine H2 Antagonists -- pharmacology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75741359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Review+article%3A+lack+of+clinical+significance+of+the+interaction+between+H2-receptor+antagonists+and+ethanol.&rft.au=Levitt%2C+M+D&rft.aulast=Levitt&rft.aufirst=M&rft.date=1993-04-01&rft.volume=7&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-09 N1 - Date created - 1993-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cholesterol exchange and lateral cholesterol pools in synaptosomal membranes of pair-fed control and chronic ethanol-treated mice. AN - 75719626; 8488977 AB - Most studies on effects of ethanol on membrane cholesterol have reported on changes in the total or bulk amount of cholesterol. Membrane cholesterol, however, can be described in terms of its kinetics and domains. The kinetics and size of lateral cholesterol exchangeable and nonexchangeable pools were examined in synaptosomes of pair-fed controls and chronic ethanol-treated mice. Effects of sphingomyelin, an exofacial leaflet phospholipid, that has been shown to affect cholesterol pools, were also examined. Radiolabeled small unilamellar vesicles were used to exchange cholesterol with synaptosomes. The total amounts of membrane cholesterol, phospholipid phosphorus, and the ratio of cholesterol to phospholipid did not differ between the pair-fed control and ethanol groups. In control mice, the rate constant (hr-1) and the t1/2 (hr) of cholesterol exchange were 0.065 +/- 0.001 and 10.7 +/- 0.25 (hr), respectively. The rate constant was significantly slower (0.053 +/- 0.001, p < 0.05) and the t1/2 significantly longer (13.33 +/- 0.58, p < 0.05) in synaptosomes of the ethanol group compared with the control group. The size of the exchangeable pool of cholesterol did not differ significantly between the two groups. Sphingomyelinase-induced hydrolysis of sphingomyelin significantly slowed cholesterol exchange with the largest effect in synaptosomes of the control group as compared with the ethanol group (p < 0.05). Hydrolysis of sphingomyelin had significantly (p < 0.05) less of an effect on cholesterol exchange in synaptosomes of the ethanol group. Membrane cholesterol can be described in terms of total content, transbilayer distribution, kinetics, and size of lateral pools.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Wood, W G AU - Rao, A M AU - Igbavboa, U AU - Semotuk, M AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 345 EP - 350 VL - 17 IS - 2 SN - 0145-6008, 0145-6008 KW - Phosphatidylcholines KW - 0 KW - Phosphatidylethanolamines KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Brain -- physiopathology KW - Animals KW - Phosphatidylethanolamines -- metabolism KW - Brain -- drug effects KW - Mice, Inbred C57BL KW - Phosphatidylcholines -- metabolism KW - Mice KW - Male KW - Synaptosomes -- drug effects KW - Cholesterol -- metabolism KW - Alcoholism -- physiopathology KW - Synaptic Membranes -- physiology KW - Synaptic Membranes -- drug effects KW - Synaptosomes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75719626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Cholesterol+exchange+and+lateral+cholesterol+pools+in+synaptosomal+membranes+of+pair-fed+control+and+chronic+ethanol-treated+mice.&rft.au=Wood%2C+W+G%3BRao%2C+A+M%3BIgbavboa%2C+U%3BSemotuk%2C+M&rft.aulast=Wood&rft.aufirst=W&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-08 N1 - Date created - 1993-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced inhibition of alveolar macrophage oxidant release in vivo and in vitro. AN - 75719089; 8387728 AB - Alcohol consumption is known to predispose the host to more frequent and severe bacterial infections, suggesting that alcohol compromises the normal immune function of the lung. The pulmonary alveolar macrophage is the resident host defense cell in the lung and forms the first line of defense against invading microorganisms. One of the mechanisms whereby alveolar macrophages kill bacteria is by releasing toxic oxygen radical species, such as superoxide anion and hydrogen peroxide. We hypothesized that chronic alcohol consumption caused alveolar macrophage dysfunction leading to inhibition of oxidant production when stimulated. Our data demonstrate that alveolar macrophages harvested from alcohol-treated rats release significantly lower quantity (p < 0.05) of both superoxide anion and hydrogen peroxide when stimulated with several different types of stimuli including heat-killed Staphylococcus aureus, soluble immune complexes or phorbol myristate acetate. Pair-fed control rats who received isocaloric quantities of maltose dextrin in their diet to compensate for the alcohol were able to produce oxidants in equal quantities when stimulated, to rats who were fed a normal diet. Similar results were noted in vitro experiments when alveolar macrophages harvested from normal rats were incubated in vitro in alcohol-containing media and then stimulated with the aforementioned stimuli. Alveolar macrophages, which had been incubated in alcohol for 4 hr, showed significant decreases in their ability to produce superoxide anion. This defect was noticeable for a period up to 8 hr following removal of alveolar macrophages from the alcohol-containing media.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Antony, V B AU - Godbey, S W AU - Hott, J W AU - Queener, S F AD - Department of Medicine, Veterans Administration Medical Center, Indianapolis, IN 46202. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 389 EP - 393 VL - 17 IS - 2 SN - 0145-6008, 0145-6008 KW - Superoxides KW - 11062-77-4 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Rats KW - Bronchoalveolar Lavage Fluid -- immunology KW - Animals KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Superoxides -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Alcoholism -- immunology KW - Macrophages, Alveolar -- drug effects KW - Macrophages, Alveolar -- immunology KW - Macrophage Activation -- immunology KW - Macrophage Activation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75719089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol-induced+inhibition+of+alveolar+macrophage+oxidant+release+in+vivo+and+in+vitro.&rft.au=Antony%2C+V+B%3BGodbey%2C+S+W%3BHott%2C+J+W%3BQueener%2C+S+F&rft.aulast=Antony&rft.aufirst=V&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-08 N1 - Date created - 1993-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos fiber type in malignant mesothelioma: an analytical scanning electron microscopic study of 94 cases. AN - 75709980; 8480769 AB - Although the association between asbestos exposure and malignant mesothelioma is indisputable, controversy continues regarding the relative contribution of the various types of asbestos fibers to the development of mesothelioma. We examined the types of asbestos fibers recovered from lung parenchyma in more than 90 cases of malignant mesothelioma from the United States, using an analytical scanning electron microscope. Almost half of the patients were former asbestos insulators or shipyard workers. The fibers were recovered from lung tissues obtained at autopsy or surgical resection by means of a sodium hypochlorite digestion procedure. Amosite asbestos was identified in 81% of the cases and accounted for 58% of all fibers 5 microns or greater in length. Tremolite/actinolite/anthophyllite were identified in 55% of the cases and accounted for 10% of all fiber types. Chrysotile was identified in 21% of the cases and accounted for 3% of fibers exceeding 5 microns in length. Crocidolite was found in 16% of the cases and accounted for 3% of fibers exceeding 5 microns in length. Nonasbestos mineral fibers (commonly found in the lungs of the general population) were observed in 71% of the cases and accounted for 25% of all fibers 5 microns or greater in length. The findings in this study are at odds with the assertion that crocidolite asbestos is responsible for most mesotheliomas in the United States. JF - American journal of industrial medicine AU - Roggli, V L AU - Pratt, P C AU - Brody, A R AD - Durham Veterans Administration, NC. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 605 EP - 614 VL - 23 IS - 4 SN - 0271-3586, 0271-3586 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Electron Probe Microanalysis KW - Aged, 80 and over KW - Humans KW - Lung -- chemistry KW - Adult KW - Lung -- ultrastructure KW - Aged KW - Middle Aged KW - Male KW - Female KW - Asbestos -- analysis KW - Lung Neoplasms -- chemistry KW - Mesothelioma -- pathology KW - Mesothelioma -- chemistry KW - Asbestos -- chemistry KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75709980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mechanism+of+gastric+hyperemia+induced+by+intragastric+hypertonic+saline+in+rats.&rft.au=Endoh%2C+K%3BKao%2C+J%3BDomek%2C+M+J%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-01-01&rft.volume=104&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-27 N1 - Date created - 1993-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 1994 Apr;25(4):609-10 [8010302] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. AN - 75709595; 8480854 AB - Catabolism of host hemoglobin by the malaria parasite liberates required amino acid precursors, but is also releases large amounts of potentially toxic heme that accumulates in parasite food vacuoles during intra-erythrocytic development. The schizonticidal drug chloroquine binds to free heme with high affinity and is concentrated in parasite food vacuoles. To better understand the disposition of heme within the host-parasite complex, we studied the balance of hemoglobin and heme in Plasmodium berghei-infected reticulocytes in the rat and compared this process in chloroquine-sensitive (CS) and chloroquine-resistant (CR) parasites. We found that CS P. berghei parasites have 1.5-fold more heme than CR parasites isolated from rats, and that CS P. berghei-infected reticulocytes accumulate more chloroquine than CR P. berghei-infected reticulocytes. Despite these differences in parasite heme content, the decrease in host cell hemoglobin content and the rate of free amino acid generation within the host-parasite complex is similar in CS and CR P. berghei-infected rat reticulocytes. The heme content of the infected reticulocyte-parasite complex decreases with increasing parasitemia but to a lesser extent than expected for the decrease in hemoglobin. Furthermore, the decrease in host-parasite heme is accelerated in the CR P. berghei infection compared with the CS P. berghei infection. Therefore, hemoglobin catabolism by malaria parasites is associated with the overall loss of heme from the host-parasite complex and with variable deposition of heme within parasites.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of tropical medicine and hygiene AU - Wood, P A AU - Eaton, J W AD - Stratton Veterans Administration Medical Center, Albany, New York. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 465 EP - 472 VL - 48 IS - 4 SN - 0002-9637, 0002-9637 KW - Hemoglobins KW - 0 KW - Heme KW - 42VZT0U6YR KW - Chloroquine KW - 886U3H6UFF KW - Abridged Index Medicus KW - Index Medicus KW - Reticulocytes -- chemistry KW - Rats KW - Erythrocytes -- parasitology KW - Erythrocytes -- chemistry KW - Animals KW - Rats, Sprague-Dawley KW - Analysis of Variance KW - Host-Parasite Interactions KW - Reticulocytes -- metabolism KW - Drug Resistance KW - Mice KW - Erythrocytes -- metabolism KW - Reticulocytes -- parasitology KW - Male KW - Hemoglobins -- analysis KW - Hemoglobins -- metabolism KW - Chloroquine -- pharmacology KW - Chloroquine -- metabolism KW - Malaria -- blood KW - Plasmodium berghei -- chemistry KW - Heme -- analysis KW - Plasmodium berghei -- metabolism KW - Malaria -- parasitology KW - Heme -- metabolism KW - Plasmodium berghei -- drug effects KW - Chloroquine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75709595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Hemoglobin+catabolism+and+host-parasite+heme+balance+in+chloroquine-sensitive+and+chloroquine-resistant+Plasmodium+berghei+infections.&rft.au=Wood%2C+P+A%3BEaton%2C+J+W&rft.aulast=Wood&rft.aufirst=P&rft.date=1993-04-01&rft.volume=48&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-26 N1 - Date created - 1993-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate. AN - 75708928; 8482320 AB - Cultured chick hepatocytes were used to investigate the hepatotoxicity of methotrexate alone and in combination with paracetamol. Treatment with methotrexate alone at concentrations as high as 1 mg/ml resulted in no toxicity in cultured chick hepatocytes, as indicated by no detachment of cells and no effect on protein synthesis or on release of the intracellular enzyme lactate dehydrogenase. However, treatment with methotrexate alone resulted in a 30% decrease in reduced glutathione levels. Combined treatment with methotrexate and paracetamol was toxic, but only in cells preinduced for cytochrome P450 1A by treatment with beta-naphthoflavone. Under these conditions, methotrexate lowered the threshold concentration of paracetamol at which toxicity was observed. This methotrexate-mediated increase in paracetamol toxicity was associated with decreased formation of the glucuronide, sulfate and thiol metabolites of paracetamol and with increased covalent binding of radiolabeled paracetamol to macromolecules. In cells pretreated with beta-naphthoflavone, additional treatment with either methotrexate or buthionine sulfoximine, an inhibitor of glutathione synthesis, together with paracetamol, was associated with decreased restoration of glutathione levels. These results suggest that methotrexate increased paracetamol toxicity by decreasing the amount of glutathione available for conjugation with reactive metabolites of paracetamol. JF - European journal of pharmacology AU - Lindenthal, J AU - Sinclair, J F AU - Howell, S AU - Cargill, I AU - Sinclair, P R AU - Taylor, T AD - Veterans Administration Center, White River Junction, VT 05009. Y1 - 1993/04/01/ PY - 1993 DA - 1993 Apr 01 SP - 289 EP - 298 VL - 228 IS - 5-6 SN - 0014-2999, 0014-2999 KW - Benzoflavones KW - 0 KW - Methionine Sulfoximine KW - 1982-67-8 KW - Acetaminophen KW - 362O9ITL9D KW - Buthionine Sulfoximine KW - 5072-26-4 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Glutathione KW - GAN16C9B8O KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Glutathione -- metabolism KW - Chick Embryo KW - Enzyme Induction -- physiology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Methionine Sulfoximine -- pharmacology KW - Methionine Sulfoximine -- analogs & derivatives KW - Drug Synergism KW - Benzoflavones -- pharmacology KW - Liver -- cytology KW - Liver -- drug effects KW - Liver -- metabolism KW - Acetaminophen -- metabolism KW - Methotrexate -- toxicity KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75708928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Toxicity+of+paracetamol+in+cultured+chick+hepatocytes+treated+with+methotrexate.&rft.au=Lindenthal%2C+J%3BSinclair%2C+J+F%3BHowell%2C+S%3BCargill%2C+I%3BSinclair%2C+P+R%3BTaylor%2C+T&rft.aulast=Lindenthal&rft.aufirst=J&rft.date=1993-04-01&rft.volume=228&rft.issue=5-6&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-28 N1 - Date created - 1993-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of alpha 2-adrenoceptors in mechanism of intragastric nicotine protection against ethanol injury in rat stomach. AN - 75676501; 8096456 AB - To elucidate the role of alpha- and beta-adrenoceptors in the mechanism of intragastric nicotine protection against ethanol-induced gastric mucosal injury, the following studies were performed. At 0.5-hr prior to the injury study, rats were pretreated with: subcutaneous control, prazosin (0.5 mg/kg) or yohimbine (5 mg/kg) to block alpha 1- or alpha 2-adrenoceptors; or intraperitoneal control, metoprolol (2 mg/kg) or butoxamine (4 mg/kg) to block beta 1- or beta 2-adrenoceptors, respectively. At 1-hr intervals, rats received intragastric vehicle or nicotine (4 mg/kg) and 40% ethanol (10 ml/kg). Total lengths of the linear gastric corpus mucosal lesions were measured by an unbiased observer using a caliper. In a separate study, 0.5-hr after subcutaneous control or yohimbine (5 mg/kg), rats were treated with intragastric vehicle or nicotine (4 mg/kg). One hour later, gastric mucus volume, gastric juice volume and pH, and titratable acid in the gastric juice were measured. In the rat stomach, the intragastric nicotine protection against 40% ethanol-induced mucosal injury was not blocked by selective alpha 1-(prazosin), beta 1-(metoprolol), or beta 2-(butoxamine) adrenoceptor antagonists. The protection was significantly reduced although not completely abolished by selective alpha 2-(yohimbine) adrenoceptor antagonist. Yohimbine also significantly reduced basal and nicotine-stimulated increase in gastric mucus volume. These data suggest that alpha 2-adrenoceptors are involved in the protective effect of intragastric nicotine against 40% ethanol-induced gastric mucosal injury possibly by a mucus-dependent mechanism. JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 713 EP - 721 VL - 38 IS - 4 SN - 0163-2116, 0163-2116 KW - Adrenergic alpha-Antagonists KW - 0 KW - Adrenergic beta-Antagonists KW - Receptors, Adrenergic, alpha KW - Receptors, Adrenergic, beta KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Receptors, Adrenergic, beta -- drug effects KW - Gastric Juice -- drug effects KW - Blood Pressure -- drug effects KW - Drug Evaluation, Preclinical KW - Adrenergic beta-Antagonists -- pharmacology KW - Male KW - Adrenergic alpha-Antagonists -- pharmacology KW - Ethanol -- administration & dosage KW - Receptors, Adrenergic, alpha -- drug effects KW - Nicotine -- administration & dosage KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75676501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Involvement+of+alpha+2-adrenoceptors+in+mechanism+of+intragastric+nicotine+protection+against+ethanol+injury+in+rat+stomach.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-04-01&rft.volume=38&rft.issue=4&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-05 N1 - Date created - 1993-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of intragastric tetramethylammonium protection against 40% ethanol injury in rat stomach. AN - 75657658; 8462370 AB - The effect of tetramethylammonium (TMA), a ganglionic stimulant, on gastric mucosal injury induced by 40% ethanol was examined. In studies I-III, rats were treated with intragastric vehicle or TMA (1 or 10 mg/kg). In study I, 1 hr after the treatment, 40% ethanol was given intragastrically. The length of the linear corpus mucosal lesions was measured unbiasedly with a caliper after another hour. In study II, mean blood pressure was assessed before and after the treatment. In study III, 1 hr after the treatment, gastric mucus and juice volumes, and titratable acid were measured. In study IV, 40% ethanol (10 ml/kg) was administered intragastrically immediately after 0.2 or 1.4 ml of intragastric vehicle treatment. One hour later, gastric lesions score was assessed as in study I. Results show that (1) intragastric TMA dose-dependently protected against 40% ethanol-induced gastric injury; (2) neither dose of intragastric TMA increased mean blood pressure; (3) there was a dose-related increase in gastric mucus secretion for TMA 1 and 10 mg/kg, and a significant increase in gastric juice volume only for TMA 10 mg/kg; and (4) the rats treated with 1.4 ml of vehicle plus 40% ethanol had significantly less injury than those treated with 0.2 ml of vehicle plus 40% ethanol. We conclude that the protective effect of intragastric TMA can be explained by its dose-related effect in enhancing gastric mucus secretion for TMA 1 and 10 mg/kg and the significantly greater increase in gastric juice volume for TMA 10 mg/kg.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Scremin, O U AU - Leung, F W AD - Research and Medical Services, Sepulveda, Veterans Administration Medical Center, California 91343. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 708 EP - 712 VL - 38 IS - 4 SN - 0163-2116, 0163-2116 KW - Ganglionic Stimulants KW - 0 KW - Quaternary Ammonium Compounds KW - Ethanol KW - 3K9958V90M KW - tetramethylammonium KW - H0W55235FC KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Gastric Juice -- drug effects KW - Blood Pressure -- drug effects KW - Drug Evaluation, Preclinical KW - Male KW - Quaternary Ammonium Compounds -- administration & dosage KW - Ethanol -- administration & dosage KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Ganglionic Stimulants -- administration & dosage KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75657658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Mechanism+of+intragastric+tetramethylammonium+protection+against+40%25+ethanol+injury+in+rat+stomach.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BScremin%2C+O+U%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-04-01&rft.volume=38&rft.issue=4&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-05 N1 - Date created - 1993-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate. AN - 75723262; 8387623 AB - Primary and first-passage dog urothelial cells (DUC and DUC-P1, respectively) exhibited an active catalytic subunit for the cyclic adenosine monophosphate (cAMP) second messenger system. Dramatic increases in cAMP levels were observed following the addition of forskolin, which elicited a time- and dose-response--dependent increase in cAMP levels. Increases in intracellular cAMP levels preceded media increases in cyclic nucleotide levels and were observed at the earliest time examined (5 minutes). The lowest effective concentration of forskolin was between 1 and 10 mumol/L. cAMP level increases as large as 20- to 100-fold were observed in cells and media. Preincubation of primary and subcultured cells with 0.1 mumol/L 12-O-tetradecanoylphorbol-13-acetate (TPA) for 60 minutes reduced the magnitude of the forskolin-induced increase in cAMP levels. To determine the mechanism by which TPA elicits its effect in primary cultures, the following test agents were used: 1.0 mumol/L staurosporine and 25 mumol/L sphingosine, protein kinase C inhibitors; 35 mumol/L cycloheximide, a protein synthesis inhibitor; 3.0 mumol/L indomethacin, an inhibitor of prostaglandin synthesis; and 0.5 mmol/L RO-20-1724, a cyclic nucleotide phosphodiesterase inhibitor. Staurosporine and sphingosine were the only agents that prevented the effect of TPA. The specificity of the TPA effect was evaluated with the following test agents: 0.2 nmol/L epidermal growth factor (EGF), 0.1 mumol/L 4 alpha-TPA (a stereoisomer of TPA), or 1.0 mumol/L A23187. In contrast to TPA, none of these agents reduced forskolin-mediated increases in cAMP. Results indicate forskolin cAMP responsiveness and regulation of this response by TPA in both primary and subcultured cells.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Metabolism: clinical and experimental AU - Thomas, D J AU - Zenser, T V AU - Davis, B B AD - Veterans Administration Medical Center, St Louis, MO 63125. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 297 EP - 302 VL - 42 IS - 3 SN - 0026-0495, 0026-0495 KW - Alkaloids KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone KW - 29925-17-5 KW - Calcimycin KW - 37H9VM9WZL KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cycloheximide KW - 98600C0908 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Staurosporine KW - H88EPA0A3N KW - Sphingosine KW - NGZ37HRE42 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Calcimycin -- pharmacology KW - Epidermal Growth Factor -- pharmacology KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone -- pharmacology KW - Models, Biological KW - Indomethacin -- pharmacology KW - Signal Transduction -- physiology KW - Protein Kinase C -- antagonists & inhibitors KW - Colforsin -- pharmacology KW - Second Messenger Systems -- physiology KW - Epithelial Cells KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Epithelium -- physiology KW - Dogs KW - Alkaloids -- pharmacology KW - Sphingosine -- pharmacology KW - Epithelium -- metabolism KW - Urinary Bladder -- metabolism KW - Urinary Bladder -- physiology KW - Cyclic AMP -- antagonists & inhibitors KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Urinary Bladder -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75723262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Cyclic+adenosine+monophosphate+response+in+primary+and+subcultured+bladder+epithelial+cells%3A+inhibition+by+12-O-tetradecanoylphorbol-13-acetate.&rft.au=Thomas%2C+D+J%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Thomas&rft.aufirst=D&rft.date=1993-03-01&rft.volume=42&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-04 N1 - Date created - 1993-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of retroviral infections on immune function in African-American intravenous drug users. AN - 75678338; 8471194 AB - To determine the effect of retrovirus infection and co-infection, and intravenous substance use, on immune function in African-Americans. A cohort of South Florida street-recruited African-American intravenous drug users formed the study population. The cohort consisted of 90 HIV-negative & human T-lymphotropic virus (HTLV)-negative, one HIV-negative & HTLV-I-positive, 11 HIV-negative & HTLV-II-positive, 79 HIV-positive & HTLV-negative, one HIV-positive & HTLV-I-positive and 21 HIV-positive & HTLV-II-positive individuals. The results reported are for the cross-sectional, baseline assessment of immune parameters. Lymphocyte phenotypic distributions and functional markers, including proliferative response to mitogens and natural killer cell cytotoxicity, were determined. Serum immunoglobulin (Ig) levels were determined as a measure of B-cell activity. HTLV-II infection was associated with increases in CD8 lymphocyte count and serum Ig, but with no other significant immunologic changes. The distribution of CD4 and CD8 percentages, CD4:CD8 ratio, phytohemagglutinin (PHA) and pokeweed mitogen (PWM) reactivity, IgA and IgG for the four retrovirus serostatus groups suggested the possibility of interactive effects in the co-infected group, as demonstrated by a trend toward lower medians for CD4 and for PHA and PWM response and higher medians for IgG, IgA and CD8. Retrovirus-seronegative intravenous drug users had significantly impaired immune status compared with non-drug-using control individuals. Immunologic dysfunction attributable to HTLV-II infection was minor compared with HIV infection in this population. Study subjects who were co-infected with HIV and HTLV demonstrated more impairment of immune function than individuals with single retrovirus infections. JF - AIDS (London, England) AU - Klimas, N G AU - Page, J B AU - Patarca, R AU - Chitwood, D AU - Morgan, R AU - Fletcher, M A AD - Miami Veterans Administration Medical Center, Florida. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 331 EP - 335 VL - 7 IS - 3 SN - 0269-9370, 0269-9370 KW - Immunoglobulins KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Lymphocyte Activation KW - Immunoglobulins -- analysis KW - Humans KW - Cohort Studies KW - Adult KW - CD4-CD8 Ratio KW - Immunophenotyping KW - African Continental Ancestry Group KW - Male KW - Female KW - HTLV-II Infections -- immunology KW - HIV Infections -- complications KW - HIV Infections -- immunology KW - African Americans KW - HTLV-II Infections -- complications KW - Substance Abuse, Intravenous -- immunology KW - Substance Abuse, Intravenous -- complications KW - HTLV-I Infections -- immunology KW - HTLV-I Infections -- complications KW - HIV-1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75678338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Effects+of+retroviral+infections+on+immune+function+in+African-American+intravenous+drug+users.&rft.au=Klimas%2C+N+G%3BPage%2C+J+B%3BPatarca%2C+R%3BChitwood%2C+D%3BMorgan%2C+R%3BFletcher%2C+M+A&rft.aulast=Klimas&rft.aufirst=N&rft.date=1993-03-01&rft.volume=7&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-17 N1 - Date created - 1993-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative cost-effectiveness analysis of theophylline and ipratropium bromide in chronic obstructive pulmonary disease. A three-center study. AN - 75618872; 8449051 AB - The charts of 311 patients receiving theophylline (T) and 289 patients receiving ipratropium bromide (IB) for COPD were reviewed to determine the total costs and cost-effectiveness of these 2 agents in 3 different health-care settings. A direct cost-accounting method assessed cost, and a Markov decision-analysis model calculated cost-effectiveness. Costs to treat toxic effects were greater for T versus IB. The types and incidences of toxic effects, by drug, were similar among the three centers. Overall costs for T were $121.40 per patient per therapy-month versus $84.56 per patient per therapy-month for IB, as determined by the cost-accounting method. The marginal cost was $366 for T over IB when extrapolated over 1 year using the Markov model. The Markov model also predicted that patients receiving IB had a greater number of complication-free therapy-months (measurement of effectiveness) than patients receiving T. We conclude that treatment with IB was less costly and more cost-effective than T. JF - Chest AU - Jubran, A AU - Gross, N AU - Ramsdell, J AU - Simonian, R AU - Schuttenhelm, K AU - Sax, M AU - Kaniecki, D J AU - Arnold, R J AU - Sonnenberg, F A AD - Division of Pulmonary and Critical Care Medicine, Edward Hines Jr. Veterans Administration Hospital, Hines, IL. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 678 EP - 684 VL - 103 IS - 3 SN - 0012-3692, 0012-3692 KW - Theophylline KW - C137DTR5RG KW - Ipratropium KW - GR88G0I6UL KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Health Maintenance Organizations -- statistics & numerical data KW - Analysis of Variance KW - Hospitals, University -- statistics & numerical data KW - Illinois KW - Humans KW - Chi-Square Distribution KW - Hospitalization -- economics KW - Aged KW - Hospitals, Veterans -- statistics & numerical data KW - Hospitals, Veterans -- economics KW - California KW - Hospitals, University -- economics KW - Health Maintenance Organizations -- economics KW - Treatment Outcome KW - Middle Aged KW - Markov Chains KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - Ipratropium -- adverse effects KW - Theophylline -- adverse effects KW - Cost of Illness KW - Theophylline -- economics KW - Ipratropium -- economics KW - Cost-Benefit Analysis -- statistics & numerical data KW - Lung Diseases, Obstructive -- epidemiology KW - Lung Diseases, Obstructive -- economics KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75618872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Comparative+cost-effectiveness+analysis+of+theophylline+and+ipratropium+bromide+in+chronic+obstructive+pulmonary+disease.+A+three-center+study.&rft.au=Jubran%2C+A%3BGross%2C+N%3BRamsdell%2C+J%3BSimonian%2C+R%3BSchuttenhelm%2C+K%3BSax%2C+M%3BKaniecki%2C+D+J%3BArnold%2C+R+J%3BSonnenberg%2C+F+A&rft.aulast=Jubran&rft.aufirst=A&rft.date=1993-03-01&rft.volume=103&rft.issue=3&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-09 N1 - Date created - 1993-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine Treatment at the Drug Dependency Program of the Minneapolis VA Medical Center: A Program Director's Perspective AN - 61630970; 199301970 AB - The integration of nicotine addiction treatment with inpatient chemical dependency treatment, as practiced at the Drug Dependency Treatment program of the Minneapolis (Minn) Veterans Administration Medical Canter, is explored through follow-up interviews with 106 patients. Nicotine recovery was incorporated into all educational & therapeutic activities as well as traditional recovery tools. It was found that 6 weeks after discharge, 58% of patients who were smokers at admission were nicotine-free or had greatly reduced use, & 98% of these were abstinent from drugs & alcohol. 8 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Pletcher, Vincent C AD - Drug Dependency Treatment Program Veterans Administration Medical Center, One Veterans Dr Minneapolis MN 55417 Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 139 EP - 145 VL - 10 IS - 2 SN - 0740-5472, 0740-5472 KW - chemical dependency-nicotine addiction treatment integration, Minneapolis (Minnesota) Veterans Administration Medical Center KW - case study KW - Veterans KW - Smoking KW - Minneapolis, Minnesota KW - Drug Addiction KW - Government Agencies KW - Treatment Methods KW - Hospitals KW - article KW - 6129: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61630970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Nicotine+Treatment+at+the+Drug+Dependency+Program+of+the+Minneapolis+VA+Medical+Center%3A+A+Program+Director%27s+Perspective&rft.au=Pletcher%2C+Vincent+C&rft.aulast=Pletcher&rft.aufirst=Vincent&rft.date=1993-03-01&rft.volume=10&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Minneapolis, Minnesota; Smoking; Veterans; Government Agencies; Hospitals; Treatment Methods; Drug Addiction ER - TY - JOUR T1 - Usefulness of a Discharge Diagnosis of Sepsis in Detecting Iatrogenic Infection and Quality of Care Problems AN - 21015627; 10091610 AB - To address the question of how often a diagnosis of sepsis in the discharge summary represents a condi tion present on hospital admission as opposed to an acquired condition, medical records from Veterans Affairs medical centers were reviewed. A random sample of discharged summaries coded for sepsis were obtained from five different hospitals. One hundred forty-one summaries involving 128 patients from 1989 were evaluated. Twenty-seven (18.7%) of the summaries were judged to be improperly coded. Of the remaining 114 summaries, 61 (53.5%) contained information supporting sepsis as an admission con dition. Comparison of other clinical attributes of these summaries indicates that patients with sepsis on ad mission have some characteristics that are different from those of patients who acquire sepsis during care. These attributes include a history of chemotherapy, an overall shorter length of stay, and a lower death rate. Sepsis, as a discharge diagnosis, cannot be as sumed to represent an iatrogenic condition or to be the result of poor care since more than half of the cases reviewed indicated that the condition was pres ent at admission. JF - Quality Assurance and Utilization Review (United States) AU - Barbour, Galen L AD - Veterans Health Administration, Department of Veterans Affairs, Washington, D.C Y1 - 1993/03// PY - 1993 DA - Mar 1993 SP - 2 EP - 5 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 8 IS - 1 SN - 0885-713X, 0885-713X KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - medical records KW - Chemotherapy KW - Quality control KW - Iatrogenic infection KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21015627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Cationic+protein+from+a+urate-calcium+oxalate+stone%3A+isolation+and+purification+of+a+shared+protein&rft.au=Binette%2C+J+P%3BBinette%2C+M+B&rft.aulast=Binette&rft.aufirst=J&rft.date=1993-01-01&rft.volume=7&rft.issue=3&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sepsis; medical records; Quality control; Chemotherapy; Iatrogenic infection; Hospitals DO - http://dx.doi.org/10.1177/0885713x9300800102 ER - TY - JOUR T1 - Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats. AN - 75638034; 8095837 AB - The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N-methyl-D-aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and that the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity. JF - Brain research AU - Finnegan, K T AU - Calder, L AU - Clikeman, J AU - Wei, S AU - Karler, R AD - Psychiatry Service, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1993/02/12/ PY - 1993 DA - 1993 Feb 12 SP - 134 EP - 138 VL - 603 IS - 1 SN - 0006-8993, 0006-8993 KW - Calcium Channel Blockers KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Verapamil KW - CJ0O37KU29 KW - Nifedipine KW - I9ZF7L6G2L KW - Haloperidol KW - J6292F8L3D KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Flunarizine KW - R7PLA2DM0J KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Brain Chemistry -- drug effects KW - Hippocampus -- metabolism KW - Stereotyped Behavior -- drug effects KW - Seizures -- prevention & control KW - Verapamil -- pharmacology KW - Methamphetamine -- antagonists & inhibitors KW - Hippocampus -- drug effects KW - Rats KW - Nifedipine -- pharmacology KW - Rats, Sprague-Dawley KW - Haloperidol -- pharmacology KW - Methamphetamine -- pharmacology KW - Flunarizine -- pharmacology KW - Male KW - Calcium Channel Blockers -- pharmacology KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - 3,4-Methylenedioxyamphetamine -- pharmacology KW - Serotonin -- metabolism KW - 3,4-Methylenedioxyamphetamine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75638034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Effects+of+L-type+calcium+channel+antagonists+on+the+serotonin-depleting+actions+of+MDMA+in+rats.&rft.au=Finnegan%2C+K+T%3BCalder%2C+L%3BClikeman%2C+J%3BWei%2C+S%3BKarler%2C+R&rft.aulast=Finnegan&rft.aufirst=K&rft.date=1993-02-12&rft.volume=603&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-16 N1 - Date created - 1993-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Processing in the Neglected Visual Field: Evidence from a Lexical Decision Task AN - 85555364; 9305314 AB - An examination of the extent to which a dissociation between visual information processing & conscious awareness of that processing exists in patients with unilateral visual neglect. Patients with left-sided visual neglect & with a dense left visual field hemianopia with no neglect (N = 4 & 1, respectively) were compared to a control group of Ss (N = 10) with no history of neurological damage or disease. An implicit semantic priming task in which patients made lexical decisions to a centrally located letter string, preceded by a laterally presented picture prime. Findings indicate that patients with unilateral, left visual neglect can extract semantic information implicitly from the same visual stimuli presented to the left or to the right visual field. However, a patient with a dense left hemianopia without neglect failed to show priming from the affected field. A second experiment employed the same stimuli & presentation conditions but required an explicit awareness of visual stimuli. As expected, the performance of neglect patients, & a hemianopic patient, was at chance in the left visual field. The semantic priming effects reported here are difficult to reconcile with any theory of neglect that postulates that information is filtered out early in the course of visual processing. Rather, the current findings indicate that the pathways critical for the formation of visual representations are at most only partially disrupted. Alternatively, neglect may also be seen as a disorder in accessing these representations intentionally. 1 Table, 2 Figures, 53 References. Adapted from the source document JF - Cognitive Neuropsychology AU - McGlinchey-Berroth, Regina AU - Milberg, William P AU - Verfaellie, Mieke AU - Alexander, Michael AU - Kilduff, Patrick T AD - Geriatric Research/Education/Clinical Centre Veterans Administration Medical Centre, 1400 V.F.W. Parkway West Roxbury MA 02132 Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 79 EP - 108 VL - 10 IS - 1 SN - 0264-3294, 0264-3294 KW - unilateral visual neglect, visual information processing/conscious awareness dissociation extent KW - semantic priming tasks KW - left-sided visual neglect/hemianopia-no neglect patients/normal controls KW - Visual Stimulation (94700) KW - Lexical Semantics (46770) KW - Vision Disorders (94350) KW - Information Processing (35900) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85555364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognitive+Neuropsychology&rft.atitle=Semantic+Processing+in+the+Neglected+Visual+Field%3A+Evidence+from+a+Lexical+Decision+Task&rft.au=McGlinchey-Berroth%2C+Regina%3BMilberg%2C+William+P%3BVerfaellie%2C+Mieke%3BAlexander%2C+Michael%3BKilduff%2C+Patrick+T&rft.aulast=McGlinchey-Berroth&rft.aufirst=Regina&rft.date=1993-02-01&rft.volume=10&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Cognitive+Neuropsychology&rft.issn=02643294&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - COGNEP N1 - SubjectsTermNotLitGenreText - Vision Disorders (94350); Lexical Semantics (46770); Visual Stimulation (94700); Information Processing (35900) ER - TY - JOUR T1 - Comparison of dideoxynucleoside drugs (DDI and zidovudine) and induction of hematopoietic toxicity using normal human bone marrow cells in vitro. AN - 75672670; 8468123 AB - The drug zidovudine (AZT), a synthetic thymidine analog, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of zidovudine has induced hematopoietic toxicity manifested by anemia, neutropenia and on occasion thrombocytopenia. Such toxicity has stimulated the development of alternative dideoxynucleoside drugs capable of exerting anti-viral potency while minimizing the risk for inducing organ toxicities. One such alternative dideoxynucleoside drug is 2',3'-dideoxyinosine (ddI). Recent therapeutic anti-viral strategy, now undergoing clinical trial, is the evaluation of combined zidovudine ddI treatment. Unfortunately a complete assessment of their potential toxicity using this drug regimen has not been thoroughly examined. We report here the results of studies comparing the toxicity profile of zidovudine versus ddI on their ability to influence several classes of hematopoietic progenitor stem cells, e.g. granulocyte--macrophage (CFU-GM), megakaryocyte (CFU-Meg) and erythroid (CFU-E/BFU-E) following in vitro co-culture with normal human bone marrow. Since the main clinical toxicity associated with zidovudine in vivo is the development of anemia, additional in vitro studies compared the dose-escalation effect of erythropoietin in the presence of combined zidovudine and ddI. CFU-GM, CFU-Meg, CFU-E and BFU-E were all reduced (P < 0.05) following incubation with either zidovudine or ddI thus determining their ID50 concentrations for these classes of hematopoietic progenitors; however, the extent of toxicity associated with ddI was lower than what was observed with zidovudine. More importantly, dose-escalation of erythropoietin was effective in reversing the inhibition observed for ddI on erythroid progenitors CFU-E and BFU-E (P < 0.05), an effect not reported with zidovudine in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) JF - International journal of immunopharmacology AU - Gallicchio, V S AU - Hughes, N K AU - Tse, K F AD - Department of Veterans Affairs, Veterans Administration Medical Center, Lexington, Kentucky. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 263 EP - 268 VL - 15 IS - 2 SN - 0192-0561, 0192-0561 KW - Erythropoietin KW - 11096-26-7 KW - Zidovudine KW - 4B9XT59T7S KW - Didanosine KW - K3GDH6OH08 KW - Index Medicus KW - AIDS/HIV KW - Bone Marrow Cells KW - Drug Interactions KW - Hematopoiesis -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Erythropoietin -- administration & dosage KW - In Vitro Techniques KW - Hematopoietic Stem Cells -- cytology KW - Colony-Forming Units Assay KW - Hematopoietic Stem Cells -- drug effects KW - Zidovudine -- adverse effects KW - Didanosine -- administration & dosage KW - Zidovudine -- administration & dosage KW - Bone Marrow -- drug effects KW - Didanosine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75672670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Comparison+of+dideoxynucleoside+drugs+%28DDI+and+zidovudine%29+and+induction+of+hematopoietic+toxicity+using+normal+human+bone+marrow+cells+in+vitro.&rft.au=Gallicchio%2C+V+S%3BHughes%2C+N+K%3BTse%2C+K+F&rft.aulast=Gallicchio&rft.aufirst=V&rft.date=1993-02-01&rft.volume=15&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-12 N1 - Date created - 1993-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiproliferative effects of interferons -alpha and -beta in combination with 5-fluorouracil, cisplatin, and cis- and trans-retinoic acid in three human lung carcinoma cell lines. AN - 75649730; 8384234 AB - We assessed the antiproliferative effect of human recombinant interferon -alpha (IFN-alpha) or -beta in combination with 5-fluorouracil (5-FU), cisplatin, or cis- or trans-retinoic acid on two human nonsmall cell lung carcinoma cell lines (SK-LU-1 and SK-MES-1) and on one human small cell lung carcinoma cell line (NCI-H69). Results were obtained by direct cell count and/or by the clonigenic assay. The three cell lines differed in their sensitivities to the antiproliferative effects of the different agents. However, both NSCLC cell lines were more responsive to IFN-beta than to IFN-alpha. The SK-MES cell line was more resistant to both IFNs than the SK-LU-1. The NCI-H69 cells were resistant to all the drugs tested, except trans-retinoic acid. The dose and time of exposure were found to be important factors in the case of IFNs and cytotoxic agents, with lower surviving fractions obtained with the higher doses and longer exposures. This finding, however, did not hold true for the retinoic acids, which showed no antiproliferative effect. Within the sensitivity of our system, we did not identify any synergistic interaction in any of the cell lines with IFN-alpha or IFN-beta and 5-FU or cisplatin. A slight synergistic interaction was observed with IFN and cis- or trans-retinoic acid in the SK-LU-1 cell line which was not thought to be clinically significant.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of interferon research AU - Arbaje, Y M AU - Bittner, G AU - Yingling, J M AU - Storer, B AU - Schiller, J H AD - Section of Oncology, William S. Middleton Memorial Veterans Administration Hospital, Madison, WI. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 25 EP - 32 VL - 13 IS - 1 SN - 0197-8357, 0197-8357 KW - Interferon Type I KW - 0 KW - Recombinant Proteins KW - Tretinoin KW - 5688UTC01R KW - Interferon-beta KW - 77238-31-4 KW - Isotretinoin KW - EH28UP18IF KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Isotretinoin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Interferon-beta -- administration & dosage KW - Interferon Type I -- administration & dosage KW - Tumor Cells, Cultured KW - Humans KW - Tretinoin -- administration & dosage KW - Cell Division -- drug effects KW - Drug Synergism KW - Recombinant Proteins -- administration & dosage KW - Cisplatin -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75649730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+research&rft.atitle=Antiproliferative+effects+of+interferons+-alpha+and+-beta+in+combination+with+5-fluorouracil%2C+cisplatin%2C+and+cis-+and+trans-retinoic+acid+in+three+human+lung+carcinoma+cell+lines.&rft.au=Arbaje%2C+Y+M%3BBittner%2C+G%3BYingling%2C+J+M%3BStorer%2C+B%3BSchiller%2C+J+H&rft.aulast=Arbaje&rft.aufirst=Y&rft.date=1993-02-01&rft.volume=13&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-19 N1 - Date created - 1993-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of chronic ethanol on the septohippocampal system: a role for neurotrophic factors? AN - 75639822; 8452192 AB - The mechanisms by which chronic ethanol exposure produces neuronal damage have not been established. Potentially ethanol may reduce normal neurotrophic influences necessary for neuronal survival, growth, and function. We hypothesized that chronic ethanol exposure might produce a decrease in the synthesis, availability, upregulation, delivery, and/or the biological activity of normally occurring neurotrophic factors, or may alter the capacity of target neurons to respond to these factors. The available evidence leading to this hypothesis and supporting data from our laboratory are discussed. JF - Alcoholism, clinical and experimental research AU - Walker, D W AU - Heaton, M B AU - Lee, N AU - King, M A AU - Hunter, B E AD - Gainesville Veterans Administration Medical Center, Florida. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 12 EP - 18 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Nerve Growth Factors KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neurons -- physiology KW - Nerve Regeneration -- physiology KW - Brain Damage, Chronic -- physiopathology KW - Septum Pellucidum -- physiopathology KW - Hippocampus -- physiopathology KW - Nerve Growth Factors -- physiology KW - Alcoholism -- physiopathology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75639822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effect+of+chronic+ethanol+on+the+septohippocampal+system%3A+a+role+for+neurotrophic+factors%3F&rft.au=Walker%2C+D+W%3BHeaton%2C+M+B%3BLee%2C+N%3BKing%2C+M+A%3BHunter%2C+B+E&rft.aulast=Walker&rft.aufirst=D&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amethystic agents and adjunct behavioral therapy and psychotherapy. AN - 75629523; 8452203 JF - Alcoholism, clinical and experimental research AU - Gallant, D AD - Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 197 EP - 198 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Cyanamide KW - 420-04-2 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Combined Modality Therapy KW - Substance Abuse Detection KW - Humans KW - Outcome and Process Assessment (Health Care) KW - Alcoholism -- rehabilitation KW - Psychotherapy KW - Cognitive Therapy KW - Cyanamide -- therapeutic use KW - Alcoholism -- psychology KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75629523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Amethystic+agents+and+adjunct+behavioral+therapy+and+psychotherapy.&rft.au=Gallant%2C+D&rft.aulast=Gallant&rft.aufirst=D&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling". AN - 75625637; 8452212 AB - Prior experience with ethanol (EtOH) withdrawal may sensitize an individual to subsequent withdrawal episodes. It has been hypothesized that the progressive intensification of the EtOH withdrawal syndrome following repeated episodes of EtOH intoxication and withdrawal may represent the manifestations of a "kindling" mechanism. The purpose of this study was to develop an animal model of EtOH withdrawal that is sensitive to the effects of prior withdrawal experience. Adult male C3H mice were chronically exposed to EtOH vapor in inhalation chambers prior to withdrawal testing. A multiple withdrawal (MW) group received 3 cycles of 16 hr EtOH vapor separated by 8-hr periods of abstinence; a single withdrawal (SW) group received a single bout of EtOH exposure (16 hr); a third group (SW-CONT) experienced a single withdrawal episode after receiving the equivalent amount of EtOH intoxication as the MW group (16 x 3 = 48 hr), but in a continuous (uninterrupted) fashion; and a fourth group (C) served as controls, not receiving any EtOH exposure throughout the study. Severity of the withdrawal response was assessed by scoring handling-induced convulsions hourly for the first 10 hr and then at 24 hr postwithdrawal. The results indicated that the severity of EtOH withdrawal seizures was significantly greater in animals that had a prior history of withdrawal episodes (MW group) in comparison to a separate group of animals that were tested following a single withdrawal from the same 16-hr intoxication period (SW group).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Becker, H C AU - Hale, R L AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 94 EP - 98 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Handling (Psychology) KW - Brain -- physiopathology KW - Animals KW - Alcoholic Intoxication -- physiopathology KW - Body Temperature Regulation -- physiology KW - Mice, Inbred C3H KW - Body Weight -- physiology KW - Disease Models, Animal KW - Mice KW - Alcoholism -- physiopathology KW - Male KW - Seizures -- physiopathology KW - Alcohol Withdrawal Delirium -- physiopathology KW - Kindling, Neurologic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75625637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Repeated+episodes+of+ethanol+withdrawal+potentiate+the+severity+of+subsequent+withdrawal+seizures%3A+an+animal+model+of+alcohol+withdrawal+%22kindling%22.&rft.au=Becker%2C+H+C%3BHale%2C+R+L&rft.aulast=Becker&rft.aufirst=H&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Measurement of nitric oxide in biological models. AN - 75603584; 8440411 AB - Nitric oxide (NO) is a small, gaseous, paramagnetic radical with a high affinity for interaction with ferrous hemoproteins such as soluble guanylate cyclase and hemoglobin. Interest in NO measurement increased exponentially with the discovery that NO or a related compound is the endothelium-derived relaxing factor (EDRF). In addition to being a potent endogenous vasodilator, NO has a role in inflammation, thrombosis, immunity, and neurotransmission. Measurement of NO is important as many of its effects (e.g., vasodilatation, inhibition of platelet aggregation) are similar to those of other substances produced by the endothelium, such as prostacyclin. NO is formed in small amounts in vivo and is rapidly destroyed by interaction with oxygen, making measurement difficult. A computerized search of the past five year's literature found NO measurements reported in fewer than 50 of 955 articles dealing with EDRF. Inhibitors of NO synthesis such as the arginine analogs or agents that inactivate NO, such as reduced hemoglobin, are commonly used as specific probes for NO, in vivo and in vitro; however, none of the NO inhibitors is completely specific. The most widely used assays use one of three strategies to detect NO: 1) NO is "trapped" by nitroso compounds, or reduced hemoglobin, forming a stable adduct that is detected by electron paramagnetic resonance (EPR) (detection threshold approximately 1 nmol); 2) NO oxidizes reduced hemoglobin to methemoglobin, which is detected by spectrophotometry (detection threshold approximately 1 nmol); 3) NO interacts with ozone producing light, "chemiluminescence" (detection threshold approximately 20 pmol). These assays can be performed to exclusively detect NO, or by adding acid and reducing agents to the sample, can measure NO and related oxides of nitrogen such as nitrite. Several new amperometric microelectrode assays offer the potential to measure smaller amounts of NO (10(-20) M), permitting NO measurement in intact issues and from single cells. This review describes the pharmacology and toxicology of NO and reviews the major techniques for measuring NO in biological models. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Archer, S AD - Veterans Administration Medical Center Minneapolis, Minnesota 55417. Y1 - 1993/02/01/ PY - 1993 DA - 1993 Feb 01 SP - 349 EP - 360 VL - 7 IS - 2 SN - 0892-6638, 0892-6638 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Humans KW - Nitric Oxide -- analysis KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75603584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Measurement+of+nitric+oxide+in+biological+models.&rft.au=Archer%2C+S&rft.aulast=Archer&rft.aufirst=S&rft.date=1993-02-01&rft.volume=7&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-29 N1 - Date created - 1993-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deoxyribonucleoside triphosphate pools and thymidine chemosensitization in human T-cell leukemia. AN - 75583955; 8429693 AB - Thymidine kills cells by depleting dCTP stores. The present experiments tested whether deoxycytidine, by replenishing dCTP pools, could prevent thymidine cytotoxicity and thymidine's enhancement of carboplatin killing in two human T-cell acute leukemia cell lines. MOLT3 and JM cells were exposed to combinations of thymidine, deoxycytidine, and carboplatin and then assessed for survival, the magnitude of thymidine-carboplatin chemosensitization, and changes in deoxyribonucleoside triphosphate pools. For both cell lines, deoxycytidine (up to 144.5 micrograms/ml x 24 h) completely restored dCTP pools but only partially protected against thymidine cytotoxicity (100-1000 micrograms/ml x 24 h) and thymidine-carboplatin sensitization (up to 60 micrograms carboplatin/ml during the last hour of thymidine). This contrasts with complete protection in prior studies using other cell types. Thymidine alone markedly increased dTTP and dGTP pools and decreased dCTP; dATP pools underwent a sharp decline which has not been observed before in any cell line. In subsequent studies 0.0336-137.3 micrograms deoxyadenosine/ml partially prevented cytotoxicity and carboplatin sensitization by 300 micrograms thymidine/ml. Together, deoxycytidine and deoxyadenosine completely prevented thymidine-carboplatin sensitization even though dATP and dCTP pools were not entirely returned to normal. These findings are discussed in regard to the unusual sensitivity of T-cell malignancies to thymidine toxicity, mechanisms of cytotoxicity and chemosensitization by thymidine, and the possibility of thymidine selectively sensitizing T-cell malignancies to killing by alkylating agents. JF - Leukemia research AU - Cohen, J D AU - Robins, H I AU - Katz, T B AU - Miller, E M AU - Kuzminsky, S R AU - Javid, M J AD - Division of Hematology-Oncology, Denver Veterans Administration Medical Center, CO 80220. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 167 EP - 174 VL - 17 IS - 2 SN - 0145-2126, 0145-2126 KW - Deoxyadenosines KW - 0 KW - Deoxyribonucleotides KW - Deoxycytidine KW - 0W860991D6 KW - Carboplatin KW - BG3F62OND5 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Deoxycytidine -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Deoxyadenosines -- metabolism KW - Carboplatin -- administration & dosage KW - Thymidine -- metabolism KW - Thymidine -- toxicity KW - Leukemia, T-Cell -- metabolism KW - Deoxyribonucleotides -- metabolism KW - Leukemia, T-Cell -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75583955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+research&rft.atitle=Deoxyribonucleoside+triphosphate+pools+and+thymidine+chemosensitization+in+human+T-cell+leukemia.&rft.au=Cohen%2C+J+D%3BRobins%2C+H+I%3BKatz%2C+T+B%3BMiller%2C+E+M%3BKuzminsky%2C+S+R%3BJavid%2C+M+J&rft.aulast=Cohen&rft.aufirst=J&rft.date=1993-02-01&rft.volume=17&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Leukemia+research&rft.issn=01452126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-10 N1 - Date created - 1993-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Childhood Physical Abuse and Combat-Related Posttraumatic Stress Disorder in Vietnam Veterans AN - 61330801; 9404284 AB - Standardized inventory, scale, & checklist data on drawn on to compare rates of childhood physical or sexual abuse among 66 Vietnam veterans with & without combat-related posttraumatic stress disorder (PTSD). Results indicate that PTSD patients report higher rates of childhood abuse. Implications for the prevention & treatment of PTSD are discussed. 1 Table, 58 References. K. Hyatt JF - The American Journal of Psychiatry AU - Bremner, J Douglas AU - Southwick, Steven M AU - Johnson, David R AU - Yehuda, Rachel AU - Charney, Dennis S AD - West Haven Veterans Administration Medical Center, #116S 950 Campbell Ave CT 06516 Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 235 EP - 239 VL - 150 IS - 2 SN - 0002-953X, 0002-953X KW - childhood physical/sexual abuse, Vietnam veterans with/without combat-related posttraumatic stress disorder KW - inventory/scale/checklist data KW - Veterans KW - Combat KW - Sexual Abuse KW - Posttraumatic Stress Disorder KW - Child Abuse KW - Child Sexual Abuse KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61330801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Childhood+Physical+Abuse+and+Combat-Related+Posttraumatic+Stress+Disorder+in+Vietnam+Veterans&rft.au=Bremner%2C+J+Douglas%3BSouthwick%2C+Steven+M%3BJohnson%2C+David+R%3BYehuda%2C+Rachel%3BCharney%2C+Dennis+S&rft.aulast=Bremner&rft.aufirst=J&rft.date=1993-02-01&rft.volume=150&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Sexual Abuse; Veterans; Child Sexual Abuse; Child Abuse; Combat; Posttraumatic Stress Disorder ER - TY - JOUR T1 - Interaction between free radicals and excitatory amino acids in the blood-brain barrier disruption after iron injury in the rat. AN - 76263102; 8145263 AB - Excitatory amino acids and oxygen free radicals have been reported to cooperate in the genesis of brain injury in vivo and in vitro. In this study, we tested the capacity of a noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801, and a 21-aminosteroid, U-74006F, tirilazad mesylate, to block the opening of the blood-brain barrier after subarachnoid injection of FeCl2, which is believed to cause a primarily "pure" free radical insult. Subarachnoid injection of FeCl2 resulted in a significant 10-fold increase in Evans blue extravasation while sham injection or NaCl injection had no effect. Pretreatment with either MK-801 or U-74006F significantly reduced the FeCl2-induced increase in capillary permeability by 43 and 63%, respectively (p < 0.05). Combined treatment with MK-801 and U-74006F resulted in a 65% reduction in vascular leakage that was not significantly greater than pretreatment with either drug alone. These results show that both excitatory amino acids and free radicals can damage the cerebral microvasculature and that an excitatory amino acid antagonist can partially protect the blood-brain barrier after free radical-induced injury. JF - Journal of neurotrauma AU - Zuccarello, M AU - Anderson, D K AD - Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1993 PY - 1993 DA - 1993 SP - 397 EP - 403 VL - 10 IS - 4 SN - 0897-7151, 0897-7151 KW - Amino Acids KW - 0 KW - Chlorides KW - Ferric Compounds KW - Free Radical Scavengers KW - Free Radicals KW - Pregnatrienes KW - Evans Blue KW - 45PG892GO1 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - ferric chloride KW - U38V3ZVV3V KW - tirilazad KW - YD064E883I KW - Index Medicus KW - Animals KW - Pregnatrienes -- pharmacology KW - Dizocilpine Maleate -- pharmacology KW - Rats KW - Subarachnoid Space KW - Rats, Sprague-Dawley KW - Intracranial Pressure -- drug effects KW - Blood Pressure -- drug effects KW - Injections KW - Male KW - Blood-Brain Barrier -- drug effects KW - Ferric Compounds -- administration & dosage KW - Ferric Compounds -- toxicity KW - Amino Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76263102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurotrauma&rft.atitle=Interaction+between+free+radicals+and+excitatory+amino+acids+in+the+blood-brain+barrier+disruption+after+iron+injury+in+the+rat.&rft.au=Zuccarello%2C+M%3BAnderson%2C+D+K&rft.aulast=Zuccarello&rft.aufirst=M&rft.date=1993-01-01&rft.volume=10&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurotrauma&rft.issn=08977151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-05 N1 - Date created - 1994-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of occupational exposure to human immunodeficiency virus 1. AN - 76137753; 8261768 JF - Comprehensive therapy AU - Breeling, J L AD - Medical Service, West Roxbury Veterans Administration Medical Center, Boston, MA 02132. Y1 - 1993 PY - 1993 DA - 1993 SP - 145 EP - 150 VL - 19 IS - 4 SN - 0098-8243, 0098-8243 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Centers for Disease Control and Prevention (U.S.) KW - Risk Factors KW - Humans KW - Guidelines as Topic KW - Universal Precautions KW - HIV Infections -- transmission KW - Infectious Disease Transmission, Patient-to-Professional KW - Occupational Diseases -- prevention & control KW - HIV Infections -- prevention & control KW - Occupational Diseases -- epidemiology KW - Primary Prevention -- methods KW - HIV-1 KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76137753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+therapy&rft.atitle=Prevention+of+occupational+exposure+to+human+immunodeficiency+virus+1.&rft.au=Breeling%2C+J+L&rft.aulast=Breeling&rft.aufirst=J&rft.date=1993-01-01&rft.volume=19&rft.issue=4&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Comprehensive+therapy&rft.issn=00988243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-25 N1 - Date created - 1994-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Progression of amiodarone induced cataracts. AN - 76035993; 8223102 AB - Amiodarone hydrochloride is a potent antiarrhythmic agent recently approved for use by the Food and Drug Administration. Anterior subcapsular lens opacities were observed in seven of fourteen patients treated with moderate to high doses of amiodarone at the Veterans Administration Medical Center in San Francisco in 1982. The present report summarizes the present status of these same fourteen patients ten years later. Anterior subcapsular lens opacities developed or progressed in all patients continuing treatment with this antiarrhythmic agent during the following ten year interval. Although Snellen visual acuities are not decreased, subtle visual impairment is present as measured by contrast sensitivity measurements with and without glare. This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug. JF - Documenta ophthalmologica. Advances in ophthalmology AU - Flach, A J AU - Dolan, B J AD - Department of Ophthalmology, Veterans Administration Hospital, San Francisco, Calif. Y1 - 1993 PY - 1993 DA - 1993 SP - 323 EP - 329 VL - 83 IS - 4 SN - 0012-4486, 0012-4486 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Vision Disorders -- diagnosis KW - Lens, Crystalline -- pathology KW - Contrast Sensitivity KW - Humans KW - Lens, Crystalline -- drug effects KW - Arrhythmias, Cardiac -- drug therapy KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Longitudinal Studies KW - Visual Acuity KW - Male KW - Cataract -- pathology KW - Cataract -- chemically induced KW - Amiodarone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76035993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Documenta+ophthalmologica.+Advances+in+ophthalmology&rft.atitle=Progression+of+amiodarone+induced+cataracts.&rft.au=Flach%2C+A+J%3BDolan%2C+B+J&rft.aulast=Flach&rft.aufirst=A&rft.date=1993-01-01&rft.volume=83&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Documenta+ophthalmologica.+Advances+in+ophthalmology&rft.issn=00124486&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-20 N1 - Date created - 1993-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Response of "benign" metastasizing leiomyoma to progestin withdrawal. Case report. AN - 75679996; 8472731 AB - We report a rare case of a benign metastasizing leiomyoma in which progestin therapy permitted or promoted pulmonary metastases, but progestin withdrawal induced a marked tumor regression. The significance of these observations is discussed relative to the estrogen and progesterone receptor positivity of this patient's tumor. JF - European journal of gynaecological oncology AU - Cohen, J D AU - Robins, H I AD - Division of Hematology/Oncology Denver Veterans Administration Medical Center. Y1 - 1993 PY - 1993 DA - 1993 SP - 44 EP - 45 VL - 14 IS - 1 SN - 0392-2936, 0392-2936 KW - Progesterone Congeners KW - 0 KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Megestrol KW - EA6LD1M70M KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - Megestrol -- therapeutic use KW - Megestrol -- adverse effects KW - Humans KW - Megestrol -- analogs & derivatives KW - Medroxyprogesterone Acetate -- therapeutic use KW - Middle Aged KW - Female KW - Medroxyprogesterone Acetate -- adverse effects KW - Neoplasms, Hormone-Dependent -- secondary KW - Uterine Neoplasms -- drug therapy KW - Progesterone Congeners -- adverse effects KW - Lung Neoplasms -- secondary KW - Uterine Neoplasms -- surgery KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Leiomyoma -- drug therapy KW - Progesterone Congeners -- therapeutic use KW - Lung Neoplasms -- chemically induced KW - Leiomyoma -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75679996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+gynaecological+oncology&rft.atitle=Response+of+%22benign%22+metastasizing+leiomyoma+to+progestin+withdrawal.+Case+report.&rft.au=Cohen%2C+J+D%3BRobins%2C+H+I&rft.aulast=Cohen&rft.aufirst=J&rft.date=1993-01-01&rft.volume=14&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=European+journal+of+gynaecological+oncology&rft.issn=03922936&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-18 N1 - Date created - 1993-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of hypoglycemia on changes of brain lactic acid and intracellular pH produced by ischemia. AN - 75653026; 8457423 AB - Previous investigators have attributed the fall of brain intracellular pH (pHi) produced by ischemia to accumulation of lactic acid. The goal of the present experiments was to examine the hypothesis that the acidosis produced by cerebral ischemia is due to accumulation of lactic acid. The present experiments inhibited lactic acid production by lowering glucose availability using insulin-induced hypoglycemia. The adverse effects of hypoglycemia were prevented by the prior elevation of beta-hydroxybutyric acid and acetoacetic acid induced by a high lipid diet. Brain pHi and lactic acid were measured by 31P and 1H NMR. The results showed that insulin-induced hypoglycemia markedly inhibits production of lactic acid, but has no effect on brain pHi during ischemia. These findings suggest that, at least under some conditions, the acidosis produced by cerebral ischemia is not due to accumulation of lactic acid. JF - NMR in biomedicine AU - Nagai, Y AU - Naruse, S AU - Weiner, M W AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1993 SP - 1 EP - 6 VL - 6 IS - 1 SN - 0952-3480, 0952-3480 KW - Insulin KW - 0 KW - Lactates KW - Phosphates KW - Triglycerides KW - Phosphocreatine KW - 020IUV4N33 KW - Lactic Acid KW - 33X04XA5AT KW - phosphocreatinine KW - 5786-71-0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Triglycerides -- pharmacology KW - Hydrogen-Ion Concentration KW - Phosphocreatine -- analogs & derivatives KW - Intracellular Fluid -- metabolism KW - Phosphates -- metabolism KW - Rats KW - Adenosine Triphosphate -- metabolism KW - Rats, Wistar KW - Phosphocreatine -- metabolism KW - Male KW - Hypoglycemia -- metabolism KW - Lactates -- biosynthesis KW - Hypoglycemia -- physiopathology KW - Brain Ischemia -- metabolism KW - Brain -- metabolism KW - Hypoglycemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75653026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+biomedicine&rft.atitle=Effect+of+hypoglycemia+on+changes+of+brain+lactic+acid+and+intracellular+pH+produced+by+ischemia.&rft.au=Nagai%2C+Y%3BNaruse%2C+S%3BWeiner%2C+M+W&rft.aulast=Nagai&rft.aufirst=Y&rft.date=1993-01-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NMR+in+biomedicine&rft.issn=09523480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-27 N1 - Date created - 1993-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma. AN - 75613818; 8382705 AB - Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition. The effects were compared to LHRH agonist [D-Trp6]LHRH and carriers [D-Lys6]LHRH, LHRH antagonist T-147, as well as to methotrexate, G-HMAQ and surgical bilateral overiectomy. Analysis of the binding data revealed that in control tumors the interaction of 125I-[D-TRP6]LHRH was consistent with the presence of one class of saturable, specific, noncooperative, high-affinity and low-capacity binding sites. Chronic treatment of mice bearing MXT tumors with LHRH analogs AJ-04 and T-121/B carrying cytotoxic radicals, but not with T-98 produced significant down-regulation of membrane receptors for LHRH. The largest decrease in dissociation binding constant and Bmax of receptors for LHRH was also found in animals treated with T-121/B. Specific, high affinity binding of 125I-labelled epidermal growth factor (EGF) was detected in the membranes from control and treated MXT tumors. Treatment with cytotoxic LHRH analogs, AJ-04, T-98 and especially with T-121/B, reduced maximal binding capacity of EGF receptors. Our results indicate that LHRH analogs carrying cytotoxic radicals retain their hormonal activity and inhibit tumor growth while inducing down-regulation of LHRH receptors. In addition, probably both components of the cytotoxic LHRH analog, peptide carriers and cytotoxic radicals, reduce the binding capacity of EGF receptors, which might be useful in the treatment of breast cancer. JF - Journal of cancer research and clinical oncology AU - Milovanovic, S R AU - Monje, E AU - Szepeshazi, K AU - Radulovic, S AU - Schally, A AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1993 PY - 1993 DA - 1993 SP - 273 EP - 278 VL - 119 IS - 5 SN - 0171-5216, 0171-5216 KW - Antineoplastic Agents KW - 0 KW - Drug Carriers KW - Free Radicals KW - Iodine Radioisotopes KW - Receptors, LHRH KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Triptorelin Pamoate KW - 57773-63-4 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Free Radicals -- toxicity KW - Animals KW - Methotrexate -- pharmacology KW - Receptor, Epidermal Growth Factor -- metabolism KW - Cell Membrane -- ultrastructure KW - Amino Acid Sequence KW - Mice KW - Triptorelin Pamoate -- pharmacology KW - Mice, Inbred Strains KW - Kinetics KW - Molecular Sequence Data KW - Cell Membrane -- metabolism KW - Methotrexate -- metabolism KW - Female KW - Mammary Neoplasms, Experimental -- ultrastructure KW - Gonadotropin-Releasing Hormone -- metabolism KW - Receptors, LHRH -- drug effects KW - Antineoplastic Agents -- administration & dosage KW - Mammary Neoplasms, Experimental -- drug therapy KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Mammary Neoplasms, Experimental -- metabolism KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology KW - Receptors, LHRH -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75613818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cancer+research+and+clinical+oncology&rft.atitle=Effect+of+treatment+with+LHRH+analogs+containing+cytotoxic+radicals+on+the+binding+characteristics+of+receptors+for+luteinizing-hormone-releasing+hormone+in+MXT+mouse+mammary+carcinoma.&rft.au=Milovanovic%2C+S+R%3BMonje%2C+E%3BSzepeshazi%2C+K%3BRadulovic%2C+S%3BSchally%2C+A&rft.aulast=Milovanovic&rft.aufirst=S&rft.date=1993-01-01&rft.volume=119&rft.issue=5&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+of+cancer+research+and+clinical+oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-30 N1 - Date created - 1993-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anatomical basis for congenital deformities of the lower extremities. Part I. The hip and thigh. AN - 75562063; 8419627 AB - Congenital deformities frequently produce problems not always discernible at birth. Often, a period of time is required for the development of signs and symptoms. The present discussion presents the intrauterine anatomy of a midterm fetus relative to conditions of the hip and thigh. Cryomicrotomy is used in this study to present the best anatomical evidence of the morphology involved. JF - Journal of the American Podiatric Medical Association AU - McCarthy, D J AU - Gessner, R AD - Surgical Service, Veterans Administration Medical Center, Baltimore, MD. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 18 EP - 28 VL - 83 IS - 1 SN - 8750-7315, 8750-7315 KW - Index Medicus KW - Cryoultramicrotomy KW - Hip Dislocation, Congenital -- embryology KW - Thigh KW - Pelvic Bones -- embryology KW - Humans KW - Foot Deformities, Congenital -- embryology KW - Gestational Age KW - Hip Dislocation, Congenital -- etiology KW - Abnormalities, Drug-Induced -- embryology KW - Leg -- abnormalities KW - Foot Deformities, Congenital -- etiology KW - Muscles -- embryology KW - Abnormalities, Drug-Induced -- etiology KW - Hip Joint -- embryology KW - Hip Joint -- abnormalities KW - Femur -- abnormalities KW - Femur -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75562063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Anatomical+basis+for+congenital+deformities+of+the+lower+extremities.+Part+I.+The+hip+and+thigh.&rft.au=McCarthy%2C+D+J%3BGessner%2C+R&rft.aulast=McCarthy&rft.aufirst=D&rft.date=1993-01-01&rft.volume=83&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immune complex glomerulonephritis with unusual microfibrillar deposits associated with primary bone marrow lymphoma. AN - 75547143; 8418626 AB - Glomerular microfibrillary deposits are characteristic of several diseases of the kidney. In a number of glomerulopathies, the nature of these microfibrillary deposits is critical in classifying the renal lesion and in suggesting the possibility of an associated systemic process. However, it is likely that as efforts are made to classify glomerulopathies with microfibrillary deposits, certain cases will defy categorization. We describe one such case in which a patient presented with rapidly progressive glomerulonephritis associated with large subepithelial, parallel-arrayed microfibrillar deposits associated with a primary bone marrow B-cell lymphoma. While IgG, C3, and lambda and kappa light chains were deposited in the glomerulus, serum and urine protein electrophoresis were normal. Treatment with Cytoxan and prednisone caused simultaneous remission of the lymphoma and the glomerulonephritis. Relapse of the lymphoma was associated with rapid deterioration of renal function. This case may represent a newly described variant of immune complex-mediated glomerulonephritis associated with microfibrillary deposits. The possibility is raised that the glomerular lesion is due to atypical immunoglobulins synthesized by a bone marrow lymphoma. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kohan, D E AU - Perkins, S L AU - Terreros, D A AD - Department of Medicine, Veterans Administration Medical Center, Salt Lake City, UT. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 47 EP - 51 VL - 21 IS - 1 SN - 0272-6386, 0272-6386 KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Drug Therapy, Combination KW - Bone Marrow -- pathology KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Prednisone -- therapeutic use KW - Humans KW - Middle Aged KW - Microscopy, Electron KW - Biopsy KW - Male KW - Immune Complex Diseases -- etiology KW - Glomerulonephritis -- etiology KW - Immune Complex Diseases -- pathology KW - Lymphoma, B-Cell -- drug therapy KW - Lymphoma, B-Cell -- complications KW - Glomerulonephritis -- pathology KW - Lymphoma, B-Cell -- pathology KW - Kidney Glomerulus -- ultrastructure KW - Neoplasm Recurrence, Local -- complications KW - Kidney Glomerulus -- pathology KW - Neoplasm Recurrence, Local -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75547143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Immune+complex+glomerulonephritis+with+unusual+microfibrillar+deposits+associated+with+primary+bone+marrow+lymphoma.&rft.au=Kohan%2C+D+E%3BPerkins%2C+S+L%3BTerreros%2C+D+A&rft.aulast=Kohan&rft.aufirst=D&rft.date=1993-01-01&rft.volume=21&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats. AN - 75546037; 8419233 AB - Intragastric hypertonic (2 mol/L) saline produces injury in the gastric mucosa and a significant increase in gastric blood flow (hyperemia) in anesthetized rats. We studied the mechanism of this hyperemia. Rats were treated with intravenous boluses of NG-nitro-L-arginine methyl ester (3 mg/kg) to block synthesis of endogenous nitric oxide, pyrilamine (1 mg/kg) to inhibit H1 receptors, or indomethacin (5 mg/kg) to block synthesis of endogenous prostaglandins during blood flow studies or with subcutaneous capsaicin (125 mg/kg) 10-14 days before blood flow studies to ablate capsaicin-sensitive afferent nerves. Gastric mucosal blood flow was measured by hydrogen gas clearance before and during intragastric administration of 2 mol/L saline. The gastric hyperemia induced by intragastric 2 mol/L saline was completely blocked only by indomethacin. The associated gastric mucosal damage was increased significantly. In the rat stomach, the gastric hyperemia induced by intragastric 2 mol/L saline is mediated by endogenous prostaglandins and plays a protective role. Endogenous nitric oxide, H1 receptors, and capsaicin-sensitive afferent nerves are not involved in this protective hyperemia. JF - Gastroenterology AU - Endoh, K AU - Kao, J AU - Domek, M J AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, California. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 114 EP - 121 VL - 104 IS - 1 SN - 0016-5085, 0016-5085 KW - Saline Solution, Hypertonic KW - 0 KW - Arginine KW - 94ZLA3W45F KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Intubation, Gastrointestinal KW - Regional Blood Flow -- drug effects KW - Arginine -- pharmacology KW - Indomethacin -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Blood Pressure -- drug effects KW - Blood Volume -- drug effects KW - Arginine -- analogs & derivatives KW - Male KW - Stomach -- pathology KW - Stomach -- blood supply KW - Saline Solution, Hypertonic -- pharmacology KW - Saline Solution, Hypertonic -- administration & dosage KW - Hyperemia -- pathology KW - Hyperemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75546037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mechanism+of+gastric+hyperemia+induced+by+intragastric+hypertonic+saline+in+rats.&rft.au=Endoh%2C+K%3BKao%2C+J%3BDomek%2C+M+J%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-01-01&rft.volume=104&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-08 N1 - Date created - 1993-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of Sex on the Induction of Anti-DNA Antibodies in Normal Mice Immunized with Bacterial DNA AN - 745931055; 12895884 AB - Immunization of normal mice with bacterial DNA elicits a significant IgG anti-DNA response and has been explored as a model of systemic Lupus erythematosus. To determine whether this induced response is influenced by sex, we have measured anti-DNA levels in normal male and female BALB/c mice immunized with single stranded DNA from E. coli as complexes with methylated bovine serum albumin (mBSA) in adjuvant. By ELISA assays, anti-DNA levels of immunized females were approximately 16-fold higher than those of immunized males; levels of antibodies to the mBSA carrier were similar, however. The antibodies from females and males showed a similar degree of cross-reactivity when assayed using other natural and synthetic DNA antigens, including mammalian DNA. These findings suggest the potentiation of anti-DNA production in females by antigen-specific mechanisms and provide further evidence that immunization with bacterial DNA replicates features of autoantibody production in SLE. JF - Lupus AU - Palmer, Scott M AU - Gilkeson, Gary S AU - Pisetsky, David S AD - Division of Rheumatology and Immunology, Durham Veterans Administration Hospital, Duke University Medical Center, Durham, NC, USA Y1 - 1993 PY - 1993 DA - 1993 SP - 251 EP - 255 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 1S SN - 0961-2033, 0961-2033 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - SLE Anti-DNA antibodies KW - Sex differences KW - Animal models KW - Enzyme-linked immunosorbent assay KW - Cross-reactivity KW - Potentiation KW - Adjuvants KW - Immunization KW - Autoantibodies KW - Bovine serum albumin KW - Anti-DNA antibodies KW - Escherichia coli KW - Immunoglobulin G KW - Systemic lupus erythematosus KW - Sex KW - A 01490:Miscellaneous KW - N 14820:DNA Metabolism & Structure KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Effect+of+Sex+on+the+Induction+of+Anti-DNA+Antibodies+in+Normal+Mice+Immunized+with+Bacterial+DNA&rft.au=Palmer%2C+Scott+M%3BGilkeson%2C+Gary+S%3BPisetsky%2C+David+S&rft.aulast=Palmer&rft.aufirst=Scott&rft.date=1993-01-01&rft.volume=2&rft.issue=1S&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/10.1177%2F096120339300200112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 25 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Cross-reactivity; Bovine serum albumin; Autoantibodies; Anti-DNA antibodies; Potentiation; Immunoglobulin G; Adjuvants; Systemic lupus erythematosus; Immunization; Sex; Escherichia coli DO - http://dx.doi.org/10.1177/096120339300200112 ER - TY - JOUR T1 - Cationic protein from a urate-calcium oxalate stone: isolation and purification of a shared protein AN - 744635401; 109471 AB - A protein extracted from a urate-calcium oxalate stone by electrodialysis is also excreted in the urine which served as the source material for its purification by FPLC after separation on an ACA44 column. It has an amino acid composition appropriate for a cationic protein. One peptide obtained by cyanogen bromide cleavage has significant (approximately 60%) homology with CD59 protein (protectin). Both proteins have wide distribution, the unknown having been found in bile, cholesterol gallstones, and the wall of the aorta. However, the two proteins appear to be immunologically different. JF - Scanning Microscopy AU - Binette, J P AU - Binette, M B AD - Veterans Administration Medical Centre, Buffalo, NY, USA Y1 - 1993 PY - 1993 DA - 1993 SP - 1107 EP - 1110 VL - 7 IS - 3 SN - 0891-7035, 0891-7035 KW - Biomedical engineering KW - Cationic KW - Immunoblot KW - Stone KW - Urine KW - Urology KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Proteins KW - Characterization KW - W4 462:BIOMEDICAL EQUIPMENT KW - W4 461:BIOENGINEERING KW - W4 801:CHEMISTRY KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744635401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Cationic+protein+from+a+urate-calcium+oxalate+stone%3A+isolation+and+purification+of+a+shared+protein&rft.au=Binette%2C+J+P%3BBinette%2C+M+B&rft.aulast=Binette&rft.aufirst=J&rft.date=1993-01-01&rft.volume=7&rft.issue=3&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Characterization; Proteins ER - TY - JOUR T1 - Psychological Debriefing of Returning Military Personnel: A Protocol for Post-Combat Intervention AN - 61346211; 9408417 AB - A twelve-session protocol for debriefing military combatants in small groups is described. Psychological debriefing is an early intervention that aims to reduce the immediate & long-term negative effects of combat-related trauma. It is, ideally, preventive rather than therapeutic. Debriefing sessions should be conducted as soon after combat as possible to prevent early reactions & the formation of negative coping behaviors. Other general guidelines include initial screening to identify appropriate participants & channel severely disturbed individuals to treatment, reinforcement of the expectation of success, separation of married individuals to special sessions, & the use of skilled group facilitators. The specific session-by-session details of the flexible protocol are provided, & session objectives & content are discussed. 1 Appendix, 33 References. Adapted from the source document. JF - Journal of Social Behavior and Personality AU - Hayman, Peter M AU - Scaturo, Douglas J AD - Dept Veterans Affairs Veterans Administration Medical Center, Bay Pines FL 33504 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 117 EP - 130 VL - 8 SN - 0886-1641, 0886-1641 KW - military combatants, psychological debriefing protocol KW - Prevention KW - Military Personnel KW - Intervention KW - Posttraumatic Stress Disorder KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61346211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Behavior+and+Personality&rft.atitle=Psychological+Debriefing+of+Returning+Military+Personnel%3A+A+Protocol+for+Post-Combat+Intervention&rft.au=Hayman%2C+Peter+M%3BScaturo%2C+Douglas+J&rft.aulast=Hayman&rft.aufirst=Peter&rft.date=1993-01-01&rft.volume=8&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Behavior+and+Personality&rft.issn=08861641&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSBPE9 N1 - SubjectsTermNotLitGenreText - Military Personnel; Intervention; Posttraumatic Stress Disorder; Prevention ER - TY - JOUR T1 - Psychological Processes in Traumatic Stress AN - 61339494; 9408434 AB - Posttraumatic stress disorder (PTSD) is a representation of an extreme on a continuum of normal reactions to traumatic stress, & not a disease entity. The case for this position is made by tracing the psychological processes involved in PTSD & showing where normal responses become problematic or pathological. The diagnostic criteria for PTSD are reviewed, & an ethological perspective that considers the biological & natural contexts of behavior & the adaptive value of psychological processes is assumed. Normal responses to trauma can become pathological when taken to extremes; eg, denial can become extreme avoidance if drugs are used to keep memory suppressed. 3 Tables, 56 References. Adapted from the source document. JF - Journal of Social Behavior and Personality AU - Weiss, Daniel S AD - Veterans Administration Medical Center U California, San Francisco 94143 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 3 EP - 28 VL - 8 SN - 0886-1641, 0886-1641 KW - posttraumatic stress disorder, psychological processes KW - Psychological Factors KW - Posttraumatic Stress Disorder KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61339494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Behavior+and+Personality&rft.atitle=Psychological+Processes+in+Traumatic+Stress&rft.au=Weiss%2C+Daniel+S&rft.aulast=Weiss&rft.aufirst=Daniel&rft.date=1993-01-01&rft.volume=8&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Behavior+and+Personality&rft.issn=08861641&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSBPE9 N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Psychological Factors ER - TY - JOUR T1 - Case Management in Two Long-Term-Care Populations: A Synthesis of Research AN - 1761714149; 199501005 AB - Synthesizes 137 empirical investigations of case management of functionally limited elderly & chronically mentally ill adult long-term care populations, comparing the implications for practice, program, & policy development. Findings distinguish three major variables related to case management for these populations: (1) the goals or outcome variables for case management may affect the timing of case management services & the course of care for each population; (2) the availability & function of informal supports is developmentally different for the two groups; & (3) there is a need for varying constellations of services for different long-term care populations. 31 References. Adapted from the source document. JF - Journal of Case Management AU - Damron-Rodriguez, JoAnn AD - Geriatric Research Education Clinical Center Veterans Administration West Los Angeles, Wilshire & Sawtelle Blvds CA 90033 Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 125 EP - 129 VL - 2 IS - 4 SN - 1061-3706, 1061-3706 KW - case management, elderly/mentally ill long-term care populations KW - empirical research review KW - Mental Patients KW - Chronic Illness KW - Elderly KW - Social Work Cases KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761714149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Case+Management&rft.atitle=Case+Management+in+Two+Long-Term-Care+Populations%3A+A+Synthesis+of+Research&rft.au=Wood%2C+W+G%3BRao%2C+A+M%3BIgbavboa%2C+U%3BSemotuk%2C+M&rft.aulast=Wood&rft.aufirst=W&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Social Work Cases; Mental Patients; Chronic Illness ER - TY - JOUR T1 - Self-Report of Depression in Elderly with and without Progressive Cognitive Deterioration AN - 1761711744; 199402430 AB - Scale data obtained from 19 patients diagnosed with probable Alzheimer's disease (AD), 27 elderly depressed with no cognitive decline, & 8 elderly depressed with cognitive decline at an initial evaluation & 2 years later reveal no differences among groups in total depression score at either test period. A within-group repeated measures t-test found those depressed with no cognitive decline to be less depressed at follow-up. Clustering scale items into emotional, cognitive, & behavioral domains revealed those depressed with no cognitive decline to endorse a greater number of emotional content items than the other 2 samples. Patients with progressive cognitive decline endorsed a minimal number of cognitive items, suggesting little insight into their illness. 3 Tables, 1 Figure, 25 References. Adapted from the source document. JF - Clinical Gerontologist AU - Nussbaum, Paul David AU - Sauer, Lori AD - Veterans Administration Medical Center (151-R) Highland Dr Pittsburgh PA 15206 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 69 EP - 80 VL - 13 IS - 1 SN - 0731-7115, 0731-7115 KW - depression self-report, elderly Alzheimer's patients KW - cognitive decline KW - scale data KW - Measurement KW - Psychological Factors KW - Depression (Psychology) KW - Alzheimer's Disease KW - Elderly KW - Verbal Accounts KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761711744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Self-Report+of+Depression+in+Elderly+with+and+without+Progressive+Cognitive+Deterioration&rft.au=Nussbaum%2C+Paul+David%3BSauer%2C+Lori&rft.aulast=Nussbaum&rft.aufirst=Paul&rft.date=1993-01-01&rft.volume=13&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Elderly; Alzheimer's Disease; Measurement; Verbal Accounts; Psychological Factors ER - TY - JOUR T1 - Caffeine use as a model of acute and chronic insomnia. AN - 73470992; 1475567 AB - It was hypothesized that the metabolic effects of caffeine, which can be objectively measured (i.e. physiological, "arousal"), could be used to develop a physiological arousal model of chronic insomnia in a group of normal young adults. Twelve normal young adult males participated for 11 nights after laboratory adaptation. Subjects received 400 mg of caffeine three times a day for 7 nights and days. As predicted, the use of caffeine resulted in increased metabolic rate. Sleep efficiency was significantly reduced by caffeine and multiple sleep latency tests (MSLTs) were significantly increased. Some adaptation to the metabolic, sleep efficiency, and MSLT effects of caffeine was seen over the week of administration. Withdrawal effects (i.e. rebound sleep or sleepiness) were not seen for metabolic, MSLT or sleep variables. The data indicated that caffeine was effective in producing significant metabolic and sleep effects and that those effects were related. The results were consistent with the interpretation that a chronic decrease in sleep efficiency associated with increased physiological arousal, although producing subjective dysphoria, does not produce a physiological sleep debt. JF - Sleep AU - Bonnet, M H AU - Arand, D L AD - Dayton Veterans Administration Medical Center, Ohio. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 526 EP - 536 VL - 15 IS - 6 SN - 0161-8105, 0161-8105 KW - Caffeine KW - 3G6A5W338E KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Acute Disease KW - Drug Administration Schedule KW - Substance Withdrawal Syndrome -- physiopathology KW - Humans KW - Energy Metabolism -- physiology KW - Circadian Rhythm -- drug effects KW - Arousal -- physiology KW - Personality Inventory KW - Psychomotor Performance -- physiology KW - Polysomnography KW - Circadian Rhythm -- physiology KW - Psychomotor Performance -- drug effects KW - Arousal -- drug effects KW - Oxygen -- blood KW - Energy Metabolism -- drug effects KW - Adult KW - Attention -- physiology KW - Substance Withdrawal Syndrome -- psychology KW - Chronic Disease KW - Models, Neurological KW - Attention -- drug effects KW - Adolescent KW - Male KW - Caffeine -- administration & dosage KW - Caffeine -- adverse effects KW - Sleep Initiation and Maintenance Disorders -- chemically induced KW - Sleep Initiation and Maintenance Disorders -- physiopathology KW - Sleep Initiation and Maintenance Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73470992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sleep&rft.atitle=Caffeine+use+as+a+model+of+acute+and+chronic+insomnia.&rft.au=Bonnet%2C+M+H%3BArand%2C+D+L&rft.aulast=Bonnet&rft.aufirst=M&rft.date=1992-12-01&rft.volume=15&rft.issue=6&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Sleep&rft.issn=01618105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-01 N1 - Date created - 1993-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of castration-induced menopausal symptoms with low dose diethylstilbestrol in men with advanced prostate cancer. AN - 73451006; 1281587 AB - Menopausal symptoms manifesting as hot flashes and sweats occur in up to 75 percent of patients following either orchiectomy or treatment with a luteinizing hormone-releasing hormone agonist for prostate cancer. As many as one third of these patients will experience symptoms severe enough to seek palliation. We treated 12 such patients with low dose diethylstilbestrol (1/3 mg daily). Nine patients demonstrated both objective and subjective improvement in their menopausal symptoms. Five patients experienced toxicity including new onset of gynecomastia or breast soreness although no patient discontinued treatment on this basis. No cardiovascular complications were noted. We conclude that low dose diethylstilbestrol is an inexpensive, effective means of controlling troublesome postorchiectomy menopausal symptoms in carefully selected patients. JF - Urology AU - Miller, J I AU - Ahmann, F R AD - Section of Urology and Hematology/Oncology, Tucson Veterans Administration Medical Center, Arizona. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 499 EP - 502 VL - 40 IS - 6 SN - 0090-4295, 0090-4295 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Prospective Studies KW - Humans KW - Gynecomastia -- chemically induced KW - Palliative Care KW - Aged KW - Middle Aged KW - Male KW - Orchiectomy -- adverse effects KW - Prostatic Neoplasms -- epidemiology KW - Diethylstilbestrol -- therapeutic use KW - Diethylstilbestrol -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Climacteric -- drug effects KW - Diethylstilbestrol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73451006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Treatment+of+castration-induced+menopausal+symptoms+with+low+dose+diethylstilbestrol+in+men+with+advanced+prostate+cancer.&rft.au=Miller%2C+J+I%3BAhmann%2C+F+R&rft.aulast=Miller&rft.aufirst=J&rft.date=1992-12-01&rft.volume=40&rft.issue=6&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=00904295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-15 N1 - Date created - 1993-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of nonsteroidal antiinflammatory drug-induced gastric ulcers with misoprostol. A double-blind multicenter study. AN - 73417401; 1473430 AB - One hundred sixty-two patients chronically ingesting ibuprofen, piroxicam, or naproxen for osteoarthritis, who had abdominal pain and an endoscopically proven gastric ulcer were evaluated for eight weeks in a randomized, double-blind trial comparing misoprostol (200 micrograms four times daily with meals and at bedtime) (N = 77) with placebo (N = 85). Patients discontinued their usual daily dose of antiarthritic medication throughout the study period, and an endoscopy was performed at four weeks and eight weeks (if necessary) to assess ulcer healing. Gastric ulcers were defined as circumscribed breaks in the gastric mucosa of 0.3 cm in diameter or greater. Misoprostol therapy significantly accelerated the rate of gastric ulcer healing compared to placebo (P = 0.033). The cumulative percent healed after four and eight weeks of therapy for misoprostol versus placebo were: 83% vs 61% at four weeks and 96% vs 90% at eight weeks (P = 0.0028 and P = 0.0977, respectively by lifetable analysis). Relief of abdominal pain did not differ significantly between the treatment groups. Misoprostol significantly accelerates the healing of ibuprofen-, piroxicam-, or naproxen-induced gastric ulcers. JF - Digestive diseases and sciences AU - Jaszewski, R AU - Graham, D Y AU - Stromatt, S C AD - Veterans Administration Medical Center, Wayne State University Affiliate Hospital, Allen Park, Michigan 48101. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1820 EP - 1824 VL - 37 IS - 12 SN - 0163-2116, 0163-2116 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Misoprostol KW - 0E43V0BB57 KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Middle Aged KW - Male KW - Female KW - Stomach Ulcer -- drug therapy KW - Misoprostol -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Misoprostol -- therapeutic use KW - Stomach Ulcer -- pathology KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73417401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Treatment+of+nonsteroidal+antiinflammatory+drug-induced+gastric+ulcers+with+misoprostol.+A+double-blind+multicenter+study.&rft.au=Jaszewski%2C+R%3BGraham%2C+D+Y%3BStromatt%2C+S+C&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1992-12-01&rft.volume=37&rft.issue=12&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of fructose feeding on glomerular structure in the rat. AN - 73414540; 1477329 JF - Journal of the American Society of Nephrology : JASN AU - Park, S K AU - Meyer, T W AD - Department of Medicine, Palo Alto Veterans Administration Medical Center, CA 94304. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1330 EP - 1332 VL - 3 IS - 6 SN - 1046-6673, 1046-6673 KW - Fructose KW - 30237-26-4 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Insulin Resistance KW - Blood Pressure -- drug effects KW - Time Factors KW - Male KW - Kidney Glomerulus -- injuries KW - Fructose -- toxicity KW - Kidney Glomerulus -- drug effects KW - Kidney Glomerulus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73414540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=The+effects+of+fructose+feeding+on+glomerular+structure+in+the+rat.&rft.au=Park%2C+S+K%3BMeyer%2C+T+W&rft.aulast=Park&rft.aufirst=S&rft.date=1992-12-01&rft.volume=3&rft.issue=6&rft.spage=1330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-05 N1 - Date created - 1993-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intragastric nicotine protection against 40% ethanol injury in rat stomach. Role of ganglionic stimulation or blockade. AN - 73413515; 1361905 AB - Intragastric nicotine (4 mg/kg) protects against 40% ethanol-induced gastric mucosal injury and raises mean blood pressure. We postulated that this protective effect was mediated by the ganglionic stimulatory property of nicotine and therefore could be abolished by ganglionic blockers. Rats were pretreated with intraperitoneal hexamethonium (10 mg/kg) or mecamylamine (2 mg/kg) to block peripheral or central autonomic ganglia, respectively. Intragastric vehicle or nicotine (4 mg/kg) was then administered. The total lengths of the linear gastric corpus mucosal lesions induced by intragastric 40% ethanol were measured by an unbiased observer using a caliper. The results showed that both intraperitoneal hexamethonium and mecamylamine pretreatments protected against 40% ethanol-induced gastric mucosal injury. Neither modified the protective effect of intragastric nicotine. The protective effect of hexamethonium and mecamylamine was associated with a significant increase in the volume of gastric mucus and gastric juice. The increase in the volume of gastric content (mucus and juice) was partially responsible for the protective effect of these ganglionic blockers. In a separate experiment, intraperitoneal nicotine (4 mg/kg) also protected against 40% ethanol-induced gastric mucosal injury and raised mean blood pressure. These data indicate that the protection against 40% ethanol-induced gastric mucosal injury is not unique to intragastric nicotine. Such protection can be induced by ganglionic blocking doses of hexamethonium and mecamylamine, or a ganglionic stimulatory dose of intraperitoneally administered nicotine. Whether ganglionic stimulation or blockade plays a role in the mechanism of intragastric nicotine protection, however, remains to be determined.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center 91343. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1840 EP - 1846 VL - 37 IS - 12 SN - 0163-2116, 0163-2116 KW - Ganglionic Blockers KW - 0 KW - Ganglionic Stimulants KW - Hexamethonium Compounds KW - Hexamethonium KW - 3C9PSP36Z2 KW - Ethanol KW - 3K9958V90M KW - Mecamylamine KW - 6EE945D3OK KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Gastric Juice -- secretion KW - Ganglionic Blockers -- pharmacology KW - Ganglionic Stimulants -- pharmacology KW - Blood Pressure -- drug effects KW - Infusions, Parenteral KW - Hexamethonium Compounds -- pharmacology KW - Male KW - Mucus -- secretion KW - Ganglia, Sympathetic -- physiology KW - Nicotine -- administration & dosage KW - Mecamylamine -- pharmacology KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73413515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+nicotine+protection+against+40%25+ethanol+injury+in+rat+stomach.+Role+of+ganglionic+stimulation+or+blockade.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1992-12-01&rft.volume=37&rft.issue=12&rft.spage=1840&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - One more look at carbamazepine in the treatment of alcohol withdrawal. AN - 73398058; 1471775 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1174 EP - 1175 VL - 16 IS - 6 SN - 0145-6008, 0145-6008 KW - Carbamazepine KW - 33CM23913M KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - Oxazepam -- therapeutic use KW - Double-Blind Method KW - Humans KW - Adult KW - Neurologic Examination -- drug effects KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Carbamazepine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73398058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=One+more+look+at+carbamazepine+in+the+treatment+of+alcohol+withdrawal.&rft.au=Gallant%2C+D+M&rft.aulast=Gallant&rft.aufirst=D&rft.date=1992-12-01&rft.volume=16&rft.issue=6&rft.spage=1174&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-27 N1 - Date created - 1993-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amiodarone-induced endothelial injury is associated with phospholipase C-mediated hydrolysis of membrane phospholipids. AN - 73386577; 1453116 AB - Phospholipids accumulate within the lysosomes of various cells from individuals taking amiodarone. Studies on cultured cells suggest that inhibition of lysosomal phospholipase A1 and phospholipase A2 by amiodarone may be responsible for this derangement in phospholipid metabolism. Inhibition of lysosomal phospholipases by amiodarone has been suggested as a mechanism of its toxicity, but this relationship has not been clearly established. To examine this question, membrane phospholipids of cultured bovine pulmonary artery endothelial cells (BPAEC) were labeled with 14C-stearic acid, 3H-arachidonic acid, 14C-choline, or 14C-ethanolamine. Radiolabeled BPAEC were then exposed to various concentrations of amiodarone, and endothelial phospholipase activity was measured by isolating and quantifying various phospholipase products. These findings were compared to a standard indicator of endothelial cytotoxicity using 51Cr release. Six-hour exposures to 5 to 20 micrograms/ml amiodarone produced no BPAEC toxicity and were accompanied by some evidence of decreased phospholipid hydrolysis. At concentrations above 20 micrograms/ml, amiodarone caused significant BPAEC toxicity as indicated by 51Cr release, and this was closely associated with the liberation of substantial amounts of 3H-arachidonic acid and 14C-stearic acid from phosphatidylcholine and phosphatidylethanolamine. In BPAEC labeled with 14C-choline and 14C-ethanolamine, cytotoxic doses of amiodarone caused accumulations of 14C-phosphocholine and phosphorylethanolamine, expected products of phospholipase C, but without increases in phospholipase A products. We conclude that exposure of BPAEC to toxic concentrations of amiodarone is associated with extensive hydrolysis of phosphatidylcholine and lysophosphatidylethanolamine via a phospholipase C-specific mechanism, and suggest that this may be a mechanism in the pathogenesis of amiodarone toxicity. JF - The Journal of laboratory and clinical medicine AU - Duane, P G AU - Rice, K L AU - Charboneau, D E AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 955 EP - 963 VL - 120 IS - 6 SN - 0022-2143, 0022-2143 KW - Fatty Acids, Nonesterified KW - 0 KW - Membrane Lipids KW - Phospholipids KW - Type C Phospholipases KW - EC 3.1.4.- KW - Amiodarone KW - N3RQ532IUT KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cattle KW - Cells, Cultured KW - Hydrolysis KW - Fatty Acids, Nonesterified -- metabolism KW - Endothelium, Vascular -- drug effects KW - Phospholipids -- metabolism KW - Membrane Lipids -- metabolism KW - Type C Phospholipases -- physiology KW - Amiodarone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73386577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Amiodarone-induced+endothelial+injury+is+associated+with+phospholipase+C-mediated+hydrolysis+of+membrane+phospholipids.&rft.au=Duane%2C+P+G%3BRice%2C+K+L%3BCharboneau%2C+D+E%3BNiewoehner%2C+D+E&rft.aulast=Duane&rft.aufirst=P&rft.date=1992-12-01&rft.volume=120&rft.issue=6&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-06 N1 - Date created - 1993-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of T-cell subsets in the response to anti-CD3 monoclonal antibodies. AN - 73386223; 1360341 AB - Administration of monoclonal antibodies (mAb) to CD3 elicits an immune response to the mAb and an acute toxic syndrome that has been attributed to the release of cytokines from activated T cells. To clarify the cellular basis for these effects, we used anti-lymphocyte mAb to deplete selected T-cell subsets from BALB/c mice prior to administration of anti-CD3. In our first series of experiments, anti-CD4 repeatedly blocked the immune response to anti-CD3, but did not prevent severe toxicity. This observation suggested that other T-cell subsets might contribute to anti-CD3 induced toxicity. Therefore, we treated mice with mAb to CD8 as well as mAb to CD4 prior to administration of anti-CD3. Despite depletion of > 95% of CD8+ and CD4+ T cells, toxicity was not suppressed. This finding cast doubt on the belief that toxicity is due to activation of either CD4+ or CD8+ T cells by anti-CD3. Therefore, we assessed the role of thymocytes (which are not deleted by the mAb) and gamma delta + T cells. Thymectomy did not prevent toxicity in CD4/CD8-depleted mice, demonstrating that thymocytes are not responsible for toxicity. Anti-alpha beta TCR mAb produced a toxic reaction similar to anti-CD3 whereas anti-gamma delta TCR mAb did not, suggesting that gamma delta+ T cells are not the source of toxic cytokines. In addition, we proved that anti-CD3-induced toxicity was not due to direct effects on macrophages or to other nonspecific factors associated with the hamster mAb. These findings imply that a few residual mature T cells in mice treated with mAb to CD4 and CD8 are sufficient for the full expression of the anti-CD3-induced toxic syndrome. To confirm that both CD4+ and CD8+ T cells can mediate toxicity, we showed that:(i) SCID mice, which normally do not develop anti-CD3-induced toxicity, can be rendered susceptible by reconstitution with purified CD4+ T cells; and (ii) CD4-knockout mice that lack CD4+ T cells but have normal CD8+ T cells are susceptible to anti-CD3-induced toxicity. These findings establish that both CD4+ and CD8+ cells contribute to the toxic effects of anti-CD3, and that relatively few cells are required to mediate the full effect. JF - Clinical immunology and immunopathology AU - Finck, B K AU - Yung, C M AU - Carteron, N L AU - Wofsy, D AD - Arthritis/Immunology Section, Veterans Administration Medical Center, San Francisco, California. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 234 EP - 241 VL - 65 IS - 3 SN - 0090-1229, 0090-1229 KW - Antibodies, Anti-Idiotypic KW - 0 KW - Antibodies, Monoclonal KW - Antigens, CD3 KW - Antigens, CD4 KW - Antigens, CD8 KW - Index Medicus KW - Lymphocyte Activation KW - Thymus Gland -- cytology KW - Animals KW - Lymphocyte Depletion KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice, Nude KW - Mice KW - Mice, SCID KW - Mice, Inbred BALB C KW - Antigens, CD4 -- immunology KW - Antigens, CD8 -- immunology KW - Antigens, CD3 -- immunology KW - Antibodies, Monoclonal -- toxicity KW - T-Lymphocyte Subsets -- immunology KW - Antibodies, Anti-Idiotypic -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73386223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+immunology+and+immunopathology&rft.atitle=The+role+of+T-cell+subsets+in+the+response+to+anti-CD3+monoclonal+antibodies.&rft.au=Finck%2C+B+K%3BYung%2C+C+M%3BCarteron%2C+N+L%3BWofsy%2C+D&rft.aulast=Finck&rft.aufirst=B&rft.date=1992-12-01&rft.volume=65&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Clinical+immunology+and+immunopathology&rft.issn=00901229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-07 N1 - Date created - 1993-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Postoperative hypertension: a multicenter, prospective, randomized comparison between intravenous nicardipine and sodium nitroprusside. AN - 73367702; 1458938 AB - To compare the efficacy and safety of iv nicardipine with sodium nitroprusside in the treatment of postoperative hypertension after both cardiac and noncardiac surgery. Multicenter, prospective, randomized, open-label study. Six tertiary referral medical centers (recovery rooms and surgical ICUs). A total of 139 patients with postoperative hypertension: i.v. nicardipine (n = 71), sodium nitroprusside (n = 68). Administration of i.v. nicardipine or sodium nitroprusside. Vital signs (BP, heart rate), hemodynamic variables, medication dosage, total number of dose changes, and time to achieve BP control were recorded. Both medications were equally effective in reducing BP in both the cardiac and noncardiac surgical groups. Under the conditions of the study, i.v. nicardipine controlled hypertension more rapidly than sodium nitroprusside (i.v. nicardipine 14.0 +/- 1.0 mins and sodium nitroprusside 30.4 +/- 3.5 mins, p = .0029). The total number of dose changes required to achieve therapeutic BP response was significantly less in the i.v. nicardipine-treated patients (i.v. nicardipine 1.5 +/- 0.2 vs. sodium nitroprusside 5.1 +/- 1.4, p < .05). Adverse effects were observed with both drugs (i.v. nicardipine 7% [5/71] and sodium nitroprusside 18% [12/68] [NS]). Intravenous nicardipine is as effective as sodium nitroprusside in the therapy of postoperative hypertension. Specific advantages have been identified. The use of i.v. nicardipine should be considered in the therapy of postoperative hypertension. JF - Critical care medicine AU - Halpern, N A AU - Goldberg, M AU - Neely, C AU - Sladen, R N AU - Goldberg, J S AU - Floyd, J AU - Gabrielson, G AU - Greenstein, R J AD - Department of Anesthesiology, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1637 EP - 1643 VL - 20 IS - 12 SN - 0090-3493, 0090-3493 KW - Nitroprusside KW - 169D1260KM KW - Nicardipine KW - CZ5312222S KW - Abridged Index Medicus KW - Index Medicus KW - Postoperative Complications -- drug therapy KW - Hemodynamics -- drug effects KW - Analysis of Variance KW - Prospective Studies KW - Humans KW - Cardiac Surgical Procedures KW - Nicardipine -- adverse effects KW - Aged KW - Middle Aged KW - Nicardipine -- therapeutic use KW - Male KW - Female KW - Survival Analysis KW - Nitroprusside -- therapeutic use KW - Nitroprusside -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73367702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Postoperative+hypertension%3A+a+multicenter%2C+prospective%2C+randomized+comparison+between+intravenous+nicardipine+and+sodium+nitroprusside.&rft.au=Halpern%2C+N+A%3BGoldberg%2C+M%3BNeely%2C+C%3BSladen%2C+R+N%3BGoldberg%2C+J+S%3BFloyd%2C+J%3BGabrielson%2C+G%3BGreenstein%2C+R+J&rft.aulast=Halpern&rft.aufirst=N&rft.date=1992-12-01&rft.volume=20&rft.issue=12&rft.spage=1637&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=00903493&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-08 N1 - Date created - 1993-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interferon-alpha prevents endotoxin-induced mortality in mice. AN - 73365091; 1446703 AB - Endotoxins, the lipopolysaccharide (LPS) moieties on the bacterial cell wall, cause many of the pathological features of Gram-negative septicemia. Tumor necrosis factor (TNF), primarily a product of monocyte/macrophages, has been shown to mediate many of the pathophysiological effects of endotoxin. Kupffer cells, the largest macrophage population in the body, release TNF when stimulated by LPS in vitro. A recombinant human hybrid interferon-alpha A/D (rIFN-alpha) markedly inhibited this LPS-elicited TNF production by Kupffer cells. The effects of rIFN-alpha were further tested in C57BL/6 mice receiving a lethal dose (400 micrograms/mouse) of LPS. All LPS-treated mice died within 2 days. Pretreatment with rIFN-alpha 1 h before LPS challenge improved the survival at 3 days to 22% (5/23, p < 0.04). In contrast, rIFN-alpha was more effective when administered 20 min after LPS injection, increasing the survival rate to 81% (13/16, p < 0.0001). TNF mRNA expression in the liver and spleen 50 min after LPS challenge, and plasma TNF 1.5 h after LPS were also reduced by either pretreatment or post-treatment with rIFN-alpha. Subsequently, experiments were carried out to test the efficacy of delayed rIFN-alpha treatment. A significant protective effect was still apparent when rIFN-alpha was administered 6, 10 and even 14 h (81%, 62% and 28% survival, respectively) after LPS challenge when serum TNF levels had already returned to near baseline. These experimental results suggest that rIFN-alpha might have a therapeutic potential for the prevention and treatment of the deleterious effects associated with endotoxemia besides mechanisms initially blocking TNF production. JF - European journal of immunology AU - Tzung, S P AU - Mahl, T C AU - Lance, P AU - Andersen, V AU - Cohen, S A AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, NY 14215. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 3097 EP - 3101 VL - 22 IS - 12 SN - 0014-2980, 0014-2980 KW - Interferon Type I KW - 0 KW - Lipopolysaccharides KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Mice KW - Female KW - Interferon Type I -- pharmacology KW - Lipopolysaccharides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73365091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=Interferon-alpha+prevents+endotoxin-induced+mortality+in+mice.&rft.au=Tzung%2C+S+P%3BMahl%2C+T+C%3BLance%2C+P%3BAndersen%2C+V%3BCohen%2C+S+A&rft.aulast=Tzung&rft.aufirst=S&rft.date=1992-12-01&rft.volume=22&rft.issue=12&rft.spage=3097&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-29 N1 - Date created - 1992-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Religious Coping and Depression among Elderly, Hospitalized Medically Ill Men AN - 61306712; 93Z8779 AB - An examination of the role of religious belief & behaviors in managing depression in a sample of 850 medically ill males age 65+, consecutively admitted to a southern US hospital. Ss were interviewed for coping techniques & religious affiliation, & depression was measured using the Geriatric Depression Scale & Hamilton Rating Scale for Depression. Findings show that men from conservative, black, & fundamentalist Protestant denominations were especially likely to use religious coping (RC). Older age, black race, retirement status, social support, & history of psychiatric problems were correlated with RC strategies. RC index scores were inversely correlated with Hamilton depression scale scores. No significant relation was found between RC & functional status. 6 Tables, 38 References. I. Shagrir JF - The American Journal of Psychiatry AU - Koenig, Harold G AU - Cohen, Harvey J AU - Blazer, Dan G AU - Pieper, Carl AU - Meador, Keith G AU - Shelp, Frank AU - Goli, Veeraindar AU - DiPasquale, Bob AD - GRECC-Veterans Administration Medical Center, 508 Fulton St Durham NC 27705 Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1693 EP - 1700 VL - 149 IS - 12 SN - 0002-953X, 0002-953X KW - depression coping strategies, medically ill male elderly KW - religious belief/behaviors KW - interview/scale data KW - hospital patients, southern US KW - Depression (Psychology) KW - Males KW - Elderly KW - Patients KW - Coping KW - Black Community KW - Illness KW - Religious Beliefs KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61306712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Religious+Coping+and+Depression+among+Elderly%2C+Hospitalized+Medically+Ill+Men&rft.au=Koenig%2C+Harold+G%3BCohen%2C+Harvey+J%3BBlazer%2C+Dan+G%3BPieper%2C+Carl%3BMeador%2C+Keith+G%3BShelp%2C+Frank%3BGoli%2C+Veeraindar%3BDiPasquale%2C+Bob&rft.aulast=Koenig&rft.aufirst=Harold&rft.date=1992-12-01&rft.volume=149&rft.issue=12&rft.spage=1693&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Religious Beliefs; Black Community; Coping; Depression (Psychology); Illness; Patients; Elderly; Males ER - TY - JOUR T1 - Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. AN - 73292433; 1385400 AB - Insulin-like growth factor (IGF)-binding proteins (IGFBPs) either inhibit or enhance IGF-stimulated cellular effects. While inhibition occurs by sequestration of IGF from cell-surface receptors, the exact mechanism of IGF-enhancement remains undefined. Human osteoblast-like bone cells in culture secrete several IGF-binding proteins, one of which we have previously identified as IGFBP-5. In this study we purified a 23-kDa IGFBP-5 from cultures of human osteoblast-like cells using ligand affinity chromatography and reversed-phase high performance liquid chromatography and tested its bioactivity in serum-free cultures of normal mouse osteoblast-like cells. Binding studies with radioiodinated IGF showed similar and relatively low affinities for IGF-I and IGF-II consistent with a carboxyl truncated IGF-binding protein. Mitogenic assays demonstrated that the binding protein, when coincubated with IGF-I or -II, enhanced mitogenesis. This enhancement was unique from other binding proteins in not requiring a preincubation period or serum co-factors. Furthermore, the osteoblast-derived IGFBP-5 stimulated mitogenesis in the absence of exogenous or endogenous IGF. Using radioiodinated IGFBP-5 we found that the binding protein could associate with the osteoblast surface, an effect which did not require IGF nor an interaction with IGF receptors. We suggest that osteoblast-derived IGFBP-5 may stimulate osteoblast mitogenesis in at least two ways, by association with IGF and by a second pathway that is independent of IGF receptor activation. JF - The Journal of biological chemistry AU - Andress, D L AU - Birnbaum, R S AD - Medical Service, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1992/11/05/ PY - 1992 DA - 1992 Nov 05 SP - 22467 EP - 22472 VL - 267 IS - 31 SN - 0021-9258, 0021-9258 KW - Carrier Proteins KW - 0 KW - Insulin-Like Growth Factor Binding Protein 5 KW - Insulin-Like Growth Factor Binding Proteins KW - Somatomedins KW - Index Medicus KW - Animals KW - Mitosis KW - Humans KW - In Vitro Techniques KW - Binding, Competitive KW - Mice KW - Drug Synergism KW - Protein Binding KW - Osteoblasts -- physiology KW - Carrier Proteins -- metabolism KW - Somatomedins -- administration & dosage KW - Osteoblasts -- cytology KW - Carrier Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73292433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Human+osteoblast-derived+insulin-like+growth+factor+%28IGF%29+binding+protein-5+stimulates+osteoblast+mitogenesis+and+potentiates+IGF+action.&rft.au=Andress%2C+D+L%3BBirnbaum%2C+R+S&rft.aulast=Andress&rft.aufirst=D&rft.date=1992-11-05&rft.volume=267&rft.issue=31&rft.spage=22467&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-01 N1 - Date created - 1992-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Affective correlates of alcohol and cocaine use. AN - 73446348; 1488932 AB - The affective correlates of alcohol and cocaine use were investigated in two studies. In the first, alcoholics (n = 50) and cocaine addicts (n = 40) were administered factor scales from the Inventory of Drinking Situations as well as the General Temperament Survey. Substance use in negative affect states was reported more often by alcoholics than by cocaine addicts, even when age and race differences were statistically controlled. Alcoholics also reported higher levels of negative temperament, and substance use in negative affect states was correlated with negative temperament across groups. In a study using subjects dependent on both drugs (n = 21), alcohol was more likely to be used in negative affect situations than was cocaine. Thus, the affective correlates of substance use are associated with both individual differences and drug-specific effects. Possible reasons for the differential association of alcohol with negative affect are proposed. JF - Addictive behaviors AU - Cannon, D S AU - Rubin, A AU - Keefe, C K AU - Black, J L AU - Leeka, J K AU - Phillips, L A AD - Psychology Service, Veterans Administration Medical Center, Dallas, TX 75216. PY - 1992 SP - 517 EP - 524 VL - 17 IS - 6 SN - 0306-4603, 0306-4603 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Arousal KW - Humans KW - Adult KW - Temperament KW - Middle Aged KW - Research Design KW - Male KW - Rehabilitation Centers KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73446348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Affective+correlates+of+alcohol+and+cocaine+use.&rft.au=Cannon%2C+D+S%3BRubin%2C+A%3BKeefe%2C+C+K%3BBlack%2C+J+L%3BLeeka%2C+J+K%3BPhillips%2C+L+A&rft.aulast=Cannon&rft.aufirst=D&rft.date=1992-11-01&rft.volume=17&rft.issue=6&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-25 N1 - Date created - 1993-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific and nonspecific effects of ethanol vapor on plasma corticosterone in mice. AN - 73404898; 1472310 AB - The intent of this study was to determine whether chronic ethanol (EtOH) vapor inhalation, with or without adjunct pyrazole (PYR) administration, was stressful in mice, as defined by increases in plasma corticosterone (CORT) concentration. Mice were randomly assigned to groups differentiated both on the basis of EtOH vapor exposure and the presence or absence of PYR administration. Blood samples for blood EtOH concentration (BEC) and plasma CORT concentration were obtained from mice after 72-96 hours of treatment. Mice were sacrificed after 96 hours of treatment and body and adrenal weight determined. BEC was significantly higher in PYR-treated animals and animals treated with the higher EtOH vapor concentration. Plasma CORT was elevated in proportion to BEC; however, other nonspecific stresses, in particular that of PYR administration, also elevated plasma CORT. Nonspecific stresses associated with this protocol may reduce the generality of these observations. Nevertheless, the high correlation between BEC and plasma CORT concentration in the PYR groups indicates that, with suitable control groups, the PYR-EtOH vapor inhalation approach is viable for studies concerned with EtOH effects on hypothalamic-anterior pituitary-adrenocortical function. JF - Alcohol (Fayetteville, N.Y.) AU - Keith, L D AU - Crabbe, J C AD - Research Service, Veterans Administration Medical Center, Portland, OR 97201. PY - 1992 SP - 529 EP - 533 VL - 9 IS - 6 SN - 0741-8329, 0741-8329 KW - Pyrazoles KW - 0 KW - Ethanol KW - 3K9958V90M KW - pyrazole KW - 3QD5KJZ7ZJ KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Pyrazoles -- pharmacology KW - Animals KW - Body Weight -- drug effects KW - Volatilization KW - Mice KW - Adrenal Glands -- drug effects KW - Stress, Physiological -- blood KW - Administration, Inhalation KW - Male KW - Organ Size -- drug effects KW - Ethanol -- blood KW - Corticosterone -- blood KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73404898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Specific+and+nonspecific+effects+of+ethanol+vapor+on+plasma+corticosterone+in+mice.&rft.au=Keith%2C+L+D%3BCrabbe%2C+J+C&rft.aulast=Keith&rft.aufirst=L&rft.date=1992-11-01&rft.volume=9&rft.issue=6&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-29 N1 - Date created - 1993-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Desipramine treatment of cocaine dependence in methadone-maintained patients. AN - 73349866; 1444727 AB - We performed a double-blind, placebo-controlled, randomized 12-week trial of desipramine hydrochloride treatment of cocaine dependence among methadone-maintained patients. Fifty-nine patients completed the 12-week medication trial (36 received desipramine and 23 received placebo), and 94% were recontacted 1, 3, and 6 months after treatment. There were significantly more dropouts in the desipramine than in the placebo group. Baseline to 12-week comparisons of Addiction Severity Index interview data indicated that both groups showed improvements. At 12 weeks, the desipramine group showed significantly better psychiatric status than the placebo group but did not differ from the placebo group on any of 21 other outcome measures, including cocaine use. During the 12-week medication phase and at the 1-month follow-up evaluation, urine toxicology screenings showed no significant difference between groups, but the placebo group had significantly less cocaine use at both the 3- and 6-month follow-up points. We conclude that desipramine has few benefits with regard to control of cocaine use in this population. JF - Archives of general psychiatry AU - Arndt, I O AU - Dorozynsky, L AU - Woody, G E AU - McLellan, A T AU - O'Brien, C P AD - Center for Studies of Addiction, Philadelphia, Veterans Administration Medical Center, PA 19104. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 888 EP - 893 VL - 49 IS - 11 SN - 0003-990X, 0003-990X KW - Placebos KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Desipramine KW - TG537D343B KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Drug Therapy, Combination KW - Double-Blind Method KW - Substance Abuse Detection KW - Humans KW - Patient Dropouts KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Comorbidity KW - Substance-Related Disorders -- diagnosis KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- complications KW - Desipramine -- therapeutic use KW - Cocaine -- urine KW - Substance-Related Disorders -- drug therapy KW - Opioid-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73349866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Desipramine+treatment+of+cocaine+dependence+in+methadone-maintained+patients.&rft.au=Arndt%2C+I+O%3BDorozynsky%2C+L%3BWoody%2C+G+E%3BMcLellan%2C+A+T%3BO%27Brien%2C+C+P&rft.aulast=Arndt&rft.aufirst=I&rft.date=1992-11-01&rft.volume=49&rft.issue=11&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-03 N1 - Date created - 1992-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats. AN - 73348476; 1443749 AB - Patients with diabetes may have peripheral neuropathy, which may have clinical implications for the use of regional nerve block. The effects of local anesthetics on nerve conduction and nerve fiber injury were tested in control rats and at 4 weeks after the onset of diabetes in rats injected with streptozotocin (50 mg/kg intraperitoneally). Nerve conduction was assessed by recording evoked electrical activity in hindpaw muscles following ipsilateral electrical stimulation of the sciatic nerve near the hip. Block of motor nerve conduction was quantified by recording the amplitude of the evoked response at 1-min intervals for up to 15 min after the injection of 500 microliters 1% lidocaine HCl or procaine HCl into the midthigh next to the sciatic nerve. In control animals, procaine was much less effective than lidocaine in producing conduction block. The rate and magnitude of lidocaine-induced conduction block were not significantly different between control and diabetic groups. However, conduction block due to procaine was sufficiently enhanced in diabetic rats to become comparable to that of lidocaine-treated control nerves. Long-lasting injury was assessed in sciatic nerve harvested 2 days after the extraneural injection of saline or 2 or 4% lidocaine HCl. Using a light microscope with a superimposed grid, nerve edema was quantified as the proportion of intersection points falling on extracellular space. Lidocaine induced edema in both control and diabetic nerves, but 4% lidocaine induced significantly more edema in diabetic nerves than in controls. Nerve fiber injury, based on light microscopic scoring of axonal degeneration and demyelination, was not observed in saline-treated nerves.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Anesthesiology AU - Kalichman, M W AU - Calcutt, N A AD - Department of Anesthesia, Veterans Administration Medical Center, San Diego, California 92161-9151. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 941 EP - 947 VL - 77 IS - 5 SN - 0003-3022, 0003-3022 KW - Procaine KW - 4Z8Y51M438 KW - Streptozocin KW - 5W494URQ81 KW - Lidocaine KW - 98PI200987 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Female KW - Neural Conduction -- physiology KW - Nerve Fibers -- physiology KW - Nerve Fibers -- drug effects KW - Neural Conduction -- drug effects KW - Procaine -- toxicity KW - Lidocaine -- toxicity KW - Diabetes Mellitus, Experimental -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73348476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Local+anesthetic-induced+conduction+block+and+nerve+fiber+injury+in+streptozotocin-diabetic+rats.&rft.au=Kalichman%2C+M+W%3BCalcutt%2C+N+A&rft.aulast=Kalichman&rft.aufirst=M&rft.date=1992-11-01&rft.volume=77&rft.issue=5&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-03 N1 - Date created - 1992-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Anesthesiology. 1993 Apr;78(4):799-800 [8466086] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Symptom reduction and sobriety in the male alcoholic. AN - 73344508; 1446963 AB - The relationship between subjective symptom reduction and sobriety was studied for 82 male alcoholics who had completed an inpatient Alcoholic Rehabilitation Unit that included six or more biofeedback/relaxation sessions. Specific symptom relief for anxiety was significantly correlated with sobriety. In addition, the reduction of symptoms showed a positive trend with sobriety. The discussion focuses on the relationship of anxiety-related symptoms and alcohol abuse. JF - The International journal of the addictions AU - Denney, M R AU - Baugh, J L AD - Veterans Administration Medical Center, Waco, Texas 76711. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1293 EP - 1300 VL - 27 IS - 11 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Biofeedback, Psychology KW - Behavior Therapy KW - Humans KW - Relaxation KW - Adult KW - Aged KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Alcoholism -- rehabilitation KW - Substance Withdrawal Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73344508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Symptom+reduction+and+sobriety+in+the+male+alcoholic.&rft.au=Denney%2C+M+R%3BBaugh%2C+J+L&rft.aulast=Denney&rft.aufirst=M&rft.date=1992-11-01&rft.volume=27&rft.issue=11&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-29 N1 - Date created - 1992-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extrapyramidal symptoms are serious side-effects of antipsychotic and other drugs. AN - 73320302; 1359485 AB - Antipsychotic medications commonly produce extrapyramidal symptoms as side effects. The extrapyramidal symptoms include acute dyskinesias and dystonic reactions, tardive dyskinesia, Parkinsonism, akinesia, akathisia, and neuroleptic malignant syndrome. Extrapyramidal symptoms are caused by dopamine blockade or depletion in the basal ganglia; this lack of dopamine often mimics idiopathic pathologies of the extrapyramidal system. Less recognized is that extrapyramidal symptoms are also associated with certain non-antipsychotic agents, including some antidepressants, lithium, various anticonvulsants, antiemetics and, rarely, oral-contraceptive agents. Extrapyramidal symptoms caused by these agents are indistinguishable from neuroleptic-induced extrapyramidal symptoms. Clinicians must be able to recognize these side effects and be able to determine the antipsychotic-induced and non-antipsychotic causes of extrapyramidal symptoms. JF - The Nurse practitioner AU - Blair, D T AU - Dauner, A AD - Colmery-O'Neil Veterans Administration Medical Center, Topeka, Kan. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 56 EP - 4, 67 VL - 17 IS - 11 SN - 0361-1817, 0361-1817 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Humans KW - Middle Aged KW - Male KW - Dyskinesia, Drug-Induced -- therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Dyskinesia, Drug-Induced -- physiopathology KW - Antipsychotic Agents -- adverse effects KW - Antipsychotic Agents -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73320302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Extrapyramidal+symptoms+are+serious+side-effects+of+antipsychotic+and+other+drugs.&rft.au=Blair%2C+D+T%3BDauner%2C+A&rft.aulast=Blair&rft.aufirst=D&rft.date=1992-11-01&rft.volume=17&rft.issue=11&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nurse Pract. 1993 Feb;18(2):13 [8096070] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. AN - 73306892; 1331172 AB - Escherichia coli endotoxin (LPS) can induce the clinical syndrome of septic shock and renal cortical necrosis and can stimulate nitric oxide (NO) production from macrophages, vascular smooth muscle, and glomerular mesangial cells in vitro. NO is an endogenous vasodilator, which also inhibits platelet aggregation and adhesion. We therefore sought to determine whether LPS would stimulate NO production in vivo and, if so, whether this NO would modulate endotoxin-induced glomerular thrombosis. The stable NO end-products, NO2 and NO3, were measured in serum and urine collections from rats during baseline and after injection of LPS, with or without substances that modulate NO synthesis. The urinary excretion of NO2/NO3 was 1,964 +/- 311 nm/8 h during the baseline and increased to 6,833 +/- 776 nm/8 h after a single intraperitoneal injection of 0.1 mg/kg LPS (P < 0.05). The serum concentration of NO2/NO3 also significantly increased after LPS injection. Both the urine and serum stimulation was significantly prevented by the NO synthesis inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME). L-Arginine, given with LPS+L-NAME significantly restored the NO2/NO3 levels in the urine. Ex vivo incubation of tissues from rats treated with LPS demonstrated NO production by the aorta, whole kidney, and glomeruli, but not cortical tubules. Histological examination of kidneys from rats given either LPS or L-NAME alone revealed that 2 and 4.5% of the glomeruli contained capillary thrombosis, respectively. In contrast, rats given LPS+L-NAME developed thrombosis in 55% of glomeruli (P < 0.001), which was significantly prevented when L-arginine was given concomitantly. We conclude that LPS stimulates endogenous production of NO in vivo and that this NO is critical in preventing LPS-induced renal thrombosis. JF - The Journal of clinical investigation AU - Shultz, P J AU - Raij, L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1718 EP - 1725 VL - 90 IS - 5 SN - 0021-9738, 0021-9738 KW - Lipopolysaccharides KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Cyclic GMP KW - H2D2X058MU KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Blood Pressure KW - Cyclic GMP -- urine KW - Arginine -- analogs & derivatives KW - Proteinuria -- etiology KW - Male KW - Arginine -- pharmacology KW - Thrombosis -- prevention & control KW - Thrombosis -- etiology KW - Nitric Oxide -- metabolism KW - Lipopolysaccharides -- toxicity KW - Kidney Glomerulus -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73306892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Endogenously+synthesized+nitric+oxide+prevents+endotoxin-induced+glomerular+thrombosis.&rft.au=Shultz%2C+P+J%3BRaij%2C+L&rft.aulast=Shultz&rft.aufirst=P&rft.date=1992-11-01&rft.volume=90&rft.issue=5&rft.spage=1718&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-22 N1 - Date created - 1992-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1991 Feb;87(2):602-8 [1671393] Kidney Int. 1977 Aug;12(2):91-5 [335145] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Hypertension. 1991 Jun;17(6 Pt 2):1045-51 [2045148] J Leukoc Biol. 1990 Dec;48(6):565-9 [2230601] J Clin Invest. 1990 Jan;85(1):264-73 [2404026] Annu Rev Pharmacol Toxicol. 1985;25:171-91 [2988418] Biochemistry. 1988 Nov 29;27(24):8706-11 [3242600] Proc Natl Acad Sci U S A. 1985 Nov;82(22):7738-42 [3906650] Thromb Diath Haemorrh Suppl. 1969;36:125-49 [5311135] Food Chem Toxicol. 1984 Jul;22(7):541-3 [6378739] J Clin Invest. 1992 Mar;89(3):867-77 [1541678] Am J Physiol. 1991 Oct;261(4 Pt 1):C634-41 [1656767] Lancet. 1991 Dec 21-28;338(8782-8783):1560-2 [1683976] Biochem Biophys Res Commun. 1990 Nov 15;172(3):1042-8 [1700903] Lancet. 1991 Dec 21-28;338(8782-8783):1557-8 [1720856] Ann Intern Med. 1991 Sep 15;115(6):457-69 [1872494] Am J Physiol. 1990 Jan;258(1 Pt 2):F162-7 [2154125] Am J Physiol. 1990 Mar;258(3 Pt 2):H655-62 [2156453] Proc Natl Acad Sci U S A. 1990 May;87(9):3629-32 [2333306] Biochem Biophys Res Commun. 1987 Nov 13;148(3):1482-9 [2825688] N Engl J Med. 1988 Jun 9;318(23):1481-6 [2835680] Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94 [3196352] Br J Pharmacol. 1987 Sep;92(1):181-7 [3311265] Am J Pathol. 1974 Apr;75(1):195-202 [4596652] Science. 1970 Nov 27;170(3961):986-8 [4920033] Kidney Int. 1984 Aug;26(2):137-43 [6239058] Anal Biochem. 1982 Oct;126(1):131-8 [7181105] Am J Physiol. 1991 Oct;261(4 Pt 2):F600-6 [1718166] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenomenology and course of psychiatric disorders associated with combat-related posttraumatic stress disorder. AN - 73288251; 1415826 AB - Studies indicate that chronic combat-related posttraumatic stress disorder (PTSD) is frequently associated with other psychiatric disorders. Questions regarding the nature and interrelationships of these conditions require clarification. The purpose of this study was to address primary and secondary illness relationships by focusing on the specific phenomenology and course of illness onset of PTSD comorbidity. In order to minimize confounding factors, only outpatients without recent substance use disorders were included. Sixty subjects who had been exposed to severe combat stress including veterans of Vietnam and veterans of World War II or Korea, 15 of whom were former prisoners of war, received structured assessments over serial evaluations. PTSD was the most prevalent lifetime disorder followed by major depression, panic disorder, generalized anxiety disorder, and phobic disorder or symptoms. Endogenous-appearing features overlapping other clinical populations were common; however, some specific symptom patterns also were suggestive of traumatic influence. Unlike generalized anxiety disorder and past substance use, the mean onset of phobias, major depression, and panic disorder, respectively, occurred later than PTSD. These observations suggest that persistent conditions related to PTSD progress toward symptoms that are increasingly autonomous in their pattern of occurrence. JF - The American journal of psychiatry AU - Mellman, T A AU - Randolph, C A AU - Brawman-Mintzer, O AU - Flores, L P AU - Milanes, F J AD - Miami Veterans Administration Medical Center, FL 33125. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1568 EP - 1574 VL - 149 IS - 11 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Age Factors KW - Depressive Disorder -- psychology KW - Humans KW - Veterans -- psychology KW - Retrospective Studies KW - Aged KW - Phobic Disorders -- epidemiology KW - Prisoners -- psychology KW - Comorbidity KW - Ambulatory Care KW - Depressive Disorder -- epidemiology KW - Phobic Disorders -- psychology KW - Adult KW - Depressive Disorder -- diagnosis KW - Anxiety Disorders -- epidemiology KW - Phobic Disorders -- diagnosis KW - Male KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Middle Aged KW - Female KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Mental Disorders -- diagnosis KW - Combat Disorders -- psychology KW - Mental Disorders -- epidemiology KW - Combat Disorders -- diagnosis KW - Mental Disorders -- psychology KW - Combat Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73288251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Phenomenology+and+course+of+psychiatric+disorders+associated+with+combat-related+posttraumatic+stress+disorder.&rft.au=Mellman%2C+T+A%3BRandolph%2C+C+A%3BBrawman-Mintzer%2C+O%3BFlores%2C+L+P%3BMilanes%2C+F+J&rft.aulast=Mellman&rft.aufirst=T&rft.date=1992-11-01&rft.volume=149&rft.issue=11&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-18 N1 - Date created - 1992-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells. AN - 73278392; 1330491 AB - Prostaglandin E2 (PGE2), PTH, and epidermal growth factor (EGF) are potent regulators of osteoblast proliferation. In UMR 106-01 rat osteosarcoma cells with osteoblast-like features, PGE2 and PTH inhibit, while EGF stimulates, mitogenesis. Both PGE2 and PTH increase intracellular cAMP levels, cytosolic calcium, and inositol phosphate turnover. In a variety of cell types, EGF mediates its effects in part via activation of receptor protein-tyrosine kinase and other protein kinases, such as protein kinase-C. The nuclear mechanisms of PGE2, PTH, and EGF regulation of osteoblast proliferation are unknown. Accordingly, we have examined the effects of these agents on mitogenesis, second messenger generation, and primary response genes, which may link second messenger activation to subsequent alterations in gene expression. Northern blot analysis of mRNA from UMR 106-01 cells treated for 3 h with 2 microM PGE2, 10 nM PTH, or 10 ng/ml EGF in the presence of cycloheximide demonstrated that all three agents induced the expression of c-fos and c-jun mRNA. In contrast, only EGF stimulated cellular proliferation and induced Egr-1 mRNA. Also, unlike PGE2 and PTH, EGF did not increase intracellular cAMP levels. c-fos mRNA was induced by treatment with 50 ng/ml tetradecanoyl phorbol acetate or by 40 ng/ml forskolin, while induction of Egr-1 mRNA was stimulated by treatment with tetradecanoyl phorbol acetate, but not forskolin. Thus, EGF signal transduction differs from that of PGE2 and PTH in UMR 106-01 osteoblast-like cells, in that EGF does not stimulate the protein kinase-A second messenger system, but causes activation of Egr-1, a primary response gene that may play a role in the mitogenic effect of EGF. JF - Endocrinology AU - Fang, M A AU - Kujubu, D A AU - Hahn, T J AD - Geriatric Research, Education, and Clinical Center, Wadsworth Veterans Administration Medical Center, Los Angeles, California 90073. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 2113 EP - 2119 VL - 131 IS - 5 SN - 0013-7227, 0013-7227 KW - Egr-1 KW - c-fos KW - c-jun KW - DNA-Binding Proteins KW - 0 KW - Early Growth Response Protein 1 KW - Egr1 protein, rat KW - Immediate-Early Proteins KW - Inositol Phosphates KW - Parathyroid Hormone KW - RNA, Messenger KW - Transcription Factors KW - Tritium KW - 10028-17-8 KW - Colforsin KW - 1F7A44V6OU KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cycloheximide KW - 98600C0908 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Protein Kinases -- physiology KW - Bone Neoplasms KW - Inositol Phosphates -- metabolism KW - Gene Expression Regulation, Neoplastic -- physiology KW - DNA-Binding Proteins -- genetics KW - RNA, Messenger -- genetics KW - Radioimmunoassay KW - Calcium -- metabolism KW - Rats KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured KW - Cycloheximide -- pharmacology KW - Enzyme Activation KW - RNA, Messenger -- analysis KW - Osteosarcoma KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Transcription Factors -- genetics KW - Thymidine -- metabolism KW - Protein Kinases -- metabolism KW - RNA, Messenger -- metabolism KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Zinc Fingers KW - Osteoblasts -- metabolism KW - Signal Transduction -- physiology KW - Parathyroid Hormone -- pharmacology KW - Osteoblasts -- physiology KW - Dinoprostone -- pharmacology KW - Signal Transduction -- drug effects KW - Mitosis -- drug effects KW - Genes, fos -- genetics KW - Epidermal Growth Factor -- pharmacology KW - Mitosis -- physiology KW - Genes, jun -- genetics KW - Osteoblasts -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73278392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+effects+of+prostaglandin+E2%2C+parathyroid+hormone%2C+and+epidermal+growth+factor+on+mitogenesis%2C+signaling%2C+and+primary+response+genes+in+UMR+106-01+osteoblast-like+cells.&rft.au=Fang%2C+M+A%3BKujubu%2C+D+A%3BHahn%2C+T+J&rft.aulast=Fang&rft.aufirst=M&rft.date=1992-11-01&rft.volume=131&rft.issue=5&rft.spage=2113&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-01 N1 - Date created - 1992-12-01 N1 - Date revised - 2017-01-13 N1 - Gene symbol - Egr-1; c-fos; c-jun N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol Use and High-Risk Behavior by Intravenous Drug Users in an AIDS Education Paradigm AN - 61308612; 9301791 AB - An experimental exploration of the relationship between alcohol consumption & high-risk behavior for human immunodeficiency virus (HIV) infection. Ss (N = 313 in-treatment intravenous drug users [IVDUs] in programs in Seattle, Wash) were randomly assigned to 1 of 3 interventions: (1) structured interview regarding risk behavior; (2) interview plus 1 group acquired immune deficiency syndrome (AIDS) education session; or (3) interview, AIDS education, & optional HIV testing. Alcohol users (N = 148) had more needle sharing & sexual partners than did nondrinkers. Follow-up interviews revealed no significant behavioral changes as a function of intervention condition or alcohol use. It is concluded that better interventions, particularly more vigorous treatment of alcohol use, are needed to reduce risk behaviors among IVDUs. 2 Tables, 3 Figures, 37 References. JF - Journal of Studies on Alcohol AU - Saxon, Andrew J AU - Calsyn, Donald A AD - Seattle Veterans Administration Medical Center, 1660 South Columbian Way Washington 98108 Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 611 EP - 618 VL - 53 IS - 6 SN - 0096-882X, 0096-882X KW - human immunodeficiency syndrome, risky alcohol/drug use/sexual behaviors, intravenous drug users KW - experimental data KW - treatment program, Seattle, Washington KW - Sexual Behavior KW - Risk KW - Educational Programs KW - Behavior Modification KW - Acquired Immune Deficiency Syndrome KW - Seattle, Washington KW - Alcohol Use KW - Drug Use KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61308612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Alcohol+Use+and+High-Risk+Behavior+by+Intravenous+Drug+Users+in+an+AIDS+Education+Paradigm&rft.au=Saxon%2C+Andrew+J%3BCalsyn%2C+Donald+A&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=1992-11-01&rft.volume=53&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Drug Use; Alcohol Use; Risk; Acquired Immune Deficiency Syndrome; Educational Programs; Seattle, Washington; Behavior Modification; Sexual Behavior ER - TY - JOUR T1 - Direct evidence for protein kinase C involvement in insulin-stimulated hexose uptake. AN - 73292692; 1417838 AB - Insulin has been reported to translocate protein kinase C (PKC) in rat adipocytes, and activation of PKC by phorbol esters is known to increase hexose uptake in these cells (1.2). To test the hypothesis that PKC may participate in insulin-stimulated hexose uptake, adipocytes were partially depleted of protein kinase C by overnight phorbol ester treatment, thereby impairing insulin effects on hexose uptake. Purified PKC was then introduced into these PKC-depleted adipocytes by electropermeabilization, and this fully restored insulin-stimulated hexose uptake. These findings provide direct evidence that PKC is required for insulin-stimulated hexose uptake. JF - Biochemical and biophysical research communications AU - Cooper, D R AU - Watson, J E AU - Hernandez, H AU - Yu, B AU - Standaert, M L AU - Ways, D K AU - Arnold, T T AU - Ishizuka, T AU - Farese, R V AD - Research Service, James A. Haley Veterans Administration Hospital, Tampa, FL 33612. Y1 - 1992/10/15/ PY - 1992 DA - 1992 Oct 15 SP - 142 EP - 148 VL - 188 IS - 1 SN - 0006-291X, 0006-291X KW - Monosaccharide Transport Proteins KW - 0 KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Rats KW - Animals KW - Glycerol -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Electric Stimulation KW - Male KW - Biological Transport -- drug effects KW - Protein Kinase C -- metabolism KW - Monosaccharide Transport Proteins -- metabolism KW - Adipose Tissue -- metabolism KW - Adipose Tissue -- drug effects KW - Deoxyglucose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73292692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Direct+evidence+for+protein+kinase+C+involvement+in+insulin-stimulated+hexose+uptake.&rft.au=Cooper%2C+D+R%3BWatson%2C+J+E%3BHernandez%2C+H%3BYu%2C+B%3BStandaert%2C+M+L%3BWays%2C+D+K%3BArnold%2C+T+T%3BIshizuka%2C+T%3BFarese%2C+R+V&rft.aulast=Cooper&rft.aufirst=D&rft.date=1992-10-15&rft.volume=188&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-19 N1 - Date created - 1992-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Auditory sensory gating and catecholamine metabolism in schizophrenic and normal subjects. AN - 85273811; pmid-1461944 AB - Diminished neuronal response to repeated sensory input is a sensory-gating phenomenon that has been found to be deficient in schizophrenic patients. For example, schizophrenic patients fail to decrease the amplitude of the P50 wave of the auditory evoked potential to the second of paired click stimuli. In some studies, however, normal subjects have also failed to decrease their P50 responses. The aim of this study was to determine if accommodation to the recording situation over time would affect the gating of the P50 response. The gating of the P50 wave is measured as the ratio of the amplitude of the second response to the amplitude of the first. Three successive auditory evoked potentials were compiled, each from trains of 32 pairs of stimuli. Twelve normal subjects and 12 schizophrenic patients were studied. Unconjugated catecholamine metabolites were measured from venous samples drawn before and after the electrophysiological recording. Between the first and third trials, the normal subjects significantly increased their gating of P50. This increase in gating of P50 was related to decreased levels of the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol. No similar phenomenon was observed in the schizophrenic patients, a number of whom had a further decrease in P50 gating over the three trials. Transient failure to observe gating of P50 in normal subjects may be related to increased state-dependent noradrenergic activity, which is known to disrupt sensory gating. This mechanism does not seem to account for the more persistent failure of sensory gating in schizophrenia. JF - Psychiatry Research AU - Waldo, M AU - Gerhardt, G AU - Baker, N AU - Drebing, C AU - Adler, L AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, CO. PY - 1992 SP - 21 EP - 32 VL - 44 IS - 1 SN - 0165-1781, 0165-1781 KW - Reference Values KW - Signal Processing, Computer-Assisted KW - Arousal KW - Auditory Pathways KW - Human KW - Electroencephalography KW - Neural Inhibition KW - Schizophrenia KW - Cerebral Cortex KW - Adult KW - Evoked Potentials, Auditory KW - Methoxyhydroxyphenylglycol KW - Acoustic Stimulation KW - Vanilmandelic Acid KW - Homovanillic Acid KW - Attention KW - Female KW - Schizophrenic Psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85273811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+Research&rft.atitle=Auditory+sensory+gating+and+catecholamine+metabolism+in+schizophrenic+and+normal+subjects.&rft.au=Waldo%2C+M%3BGerhardt%2C+G%3BBaker%2C+N%3BDrebing%2C+C%3BAdler%2C+L%3BFreedman%2C+R&rft.aulast=Waldo&rft.aufirst=M&rft.date=1992-10-01&rft.volume=44&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Psychiatry+Research&rft.issn=01651781&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. AN - 85257808; pmid-1450287 AB - Diminished gating of the P50 auditory evoked response to repeated stimuli is a psychophysiological feature of schizophrenia, that is also present in many relatives of patients. Animal models of auditory sensory gating indicate that nicotinic cholinergic neurotransmission is a critical neuronal substrate. The aim of this experiment was to determine if the deficit in sensory gating could be reversed by nicotine administration. Nonsmoking relatives of schizophrenics with abnormal sensory gating were selected as subjects for this initial double-blind trial, to avoid effects of psychotropic medications that might complicate trials in schizophrenic patients themselves. Nicotine-containing gum increased P50 sensory gating to near normal levels within 30 min of administration. The effect was transient; the gating of P50 returned to baseline levels within 1 hr. There was no change observed after placebo administration. In one of the subjects, the anticholinesterase inhibitor physostigmine similarly normalized P50 gating. The results are consistent with the hypothesis that nicotinic cholinergic neurotransmission may mediate a familial psychophysiological deficit in schizophrenia. JF - Biological Psychiatry AU - Adler, L E AU - Hoffer, L J AU - Griffith, J AU - Waldo, M C AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado. PY - 1992 SP - 607 EP - 616 VL - 32 IS - 7 SN - 0006-3223, 0006-3223 KW - Support, U.S. Gov't, P.H.S. KW - Signal Processing, Computer-Assisted KW - Double-Blind Method KW - Arousal KW - Chewing Gum KW - Human KW - Electroencephalography KW - Schizophrenia KW - Receptors, Nicotinic KW - Nicotine KW - Receptors, Muscarinic KW - Adult KW - Evoked Potentials, Auditory KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Physostigmine KW - Attention KW - Male KW - Female KW - Schizophrenic Psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85257808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Normalization+by+nicotine+of+deficient+auditory+sensory+gating+in+the+relatives+of+schizophrenics.&rft.au=Adler%2C+L+E%3BHoffer%2C+L+J%3BGriffith%2C+J%3BWaldo%2C+M+C%3BFreedman%2C+R&rft.aulast=Adler&rft.aufirst=L&rft.date=1992-10-01&rft.volume=32&rft.issue=7&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cryptococcal meningitis in patients with AIDS. AN - 73228447; 1402150 AB - In the U.S., cryptococcal meningitis is the most common form of fungal meningitis and a major cause of morbidity and mortality among immuno-suppressed patients. In the AIDS patient, cryptococcal meningitis often presents with fever and headache and is best treated with intravenous amphotericin B and oral flucytosine, or fluconazole. However, toxic effects may result from the therapy. This disease frequently relapses necessitating life-long treatment to prevent reactivation. Essential management principles focusing upon health education are presented to promote comprehensive nursing care for patients testing positive for the human immunodeficiency virus who also have cryptococcal meningitis. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Mocsny, N AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 265 EP - 268 VL - 24 IS - 5 SN - 0888-0395, 0888-0395 KW - Amphotericin B KW - 7XU7A7DROE KW - Fluconazole KW - 8VZV102JFY KW - Flucytosine KW - D83282DT06 KW - Index Medicus KW - Nursing KW - AIDS/HIV KW - Drug Therapy, Combination KW - Patient Education as Topic KW - Nursing Assessment KW - Fluconazole -- therapeutic use KW - Humans KW - Neurologic Examination KW - Amphotericin B -- therapeutic use KW - Flucytosine -- therapeutic use KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Meningitis, Cryptococcal -- drug therapy KW - Meningitis, Cryptococcal -- diagnosis KW - AIDS-Related Opportunistic Infections -- nursing KW - AIDS-Related Opportunistic Infections -- diagnosis KW - Meningitis, Cryptococcal -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73228447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Cryptococcal+meningitis+in+patients+with+AIDS.&rft.au=Mocsny%2C+N&rft.aulast=Mocsny&rft.aufirst=N&rft.date=1992-10-01&rft.volume=24&rft.issue=5&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-20 N1 - Date created - 1992-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics and implications of desflurane metabolism and toxicity. AN - 73187333; 1524235 AB - The metabolism of desflurane has been assessed both in animals and humans by measuring the appearance of fluoride metabolites (fluoride ion, nonvolatile organic fluoride, trifluoroacetic acid) in blood and urine. Desflurane administered to rats (either pretreated or not pretreated with phenobarbital or ethanol) for 3.2 MAC-hours and to swine for 5.5 MAC-hours produced fluoride ion levels in blood that were almost indistinguishable from values measured in control animals. In contrast, a significant 17% increase in plasma fluoride ion concentration in swine was detected 4 h after exposure to desflurane. In human studies, desflurane administered to patients (3.1 MAC-hours) and volunteers (7.35 MAC-hours) resulted in postanesthesia serum fluoride in concentrations that did not differ from background fluoride ion concentrations. Similarly, postanesthetic urinary excretion of fluoride ion and organic fluoride in volunteers was comparable to preanesthetic excretion rates. Small but statistically significant levels of trifluoroacetic acid were found in both serum and urine from volunteers after exposure to desflurane. Peak serum concentrations averaging 0.38 +/- 0.17 microM trifluoroacetic acid (mean +/- SD) and peak urinary excretion rates averaging 0.169 +/- 0.107 mumol/h were detected in volunteers 24 h after desflurane exposure. Although these increases in trifluoroacetic acid after exposure to desflurane were statistically significant, they are approximately 10-fold less than levels seen after exposure to isoflurane. Desflurane strongly resists biodegradation, and only a small amount is metabolized in animals and humans. JF - Anesthesia and analgesia AU - Koblin, D D AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - S10 EP - S16 VL - 75 IS - 4 Suppl SN - 0003-2999, 0003-2999 KW - Anesthetics KW - 0 KW - desflurane KW - CRS35BZ94Q KW - Isoflurane KW - CYS9AKD70P KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Anesthetics -- toxicity KW - Isoflurane -- toxicity KW - Isoflurane -- metabolism KW - Isoflurane -- adverse effects KW - Anesthetics -- adverse effects KW - Anesthesia, Inhalation KW - Anesthetics -- metabolism KW - Isoflurane -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73187333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Characteristics+and+implications+of+desflurane+metabolism+and+toxicity.&rft.au=Koblin%2C+D+D&rft.aulast=Koblin&rft.aufirst=D&rft.date=1992-10-01&rft.volume=75&rft.issue=4+Suppl&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-15 N1 - Date created - 1992-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role for protein synthesis in the neurotoxic effects of methamphetamine in mice and rats. AN - 73335923; 1446227 AB - The mechanism by which the amphetamines damage selectively nigrostriatal dopaminergic neurons in experimental animals remains uncertain. The observation that neuronal cell death during embryogenesis involves an activation of gene expression and new protein synthesis, coupled with recent reports indicating that the amphetamines are capable of inducing neuropeptide biosynthesis, offers a possible clue as to their neurotoxic mechanism of action. Based on these considerations, we evaluated the effects of two different inhibitors of protein synthesis, cycloheximide and anisomycin, on the long-term, amine-depleting effects of methamphetamine (METH) in mice and rats. Both inhibitors were found to block the amine-depleting effects of METH in these species. In other experiments, cycloheximide did not affect the functional integrity of dopaminergic or glutamatergic neurons, transmitter systems previously implicated in the neurotoxic mechanism of action of METH. These findings raise the possibility that the neuronal-damaging effects of METH are mediated via a synthesis of 'neurotoxic' proteins. JF - Brain research AU - Finnegan, K T AU - Karler, R AD - Psychiatry Service, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1992/09/18/ PY - 1992 DA - 1992 Sep 18 SP - 160 EP - 164 VL - 591 IS - 1 SN - 0006-8993, 0006-8993 KW - Nerve Tissue Proteins KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Anisomycin KW - 6C74YM2NGI KW - Cycloheximide KW - 98600C0908 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Mice KW - Male KW - Cycloheximide -- pharmacology KW - Brain -- drug effects KW - Dopamine -- metabolism KW - Nerve Tissue Proteins -- biosynthesis KW - Anisomycin -- pharmacology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73335923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Role+for+protein+synthesis+in+the+neurotoxic+effects+of+methamphetamine+in+mice+and+rats.&rft.au=Finnegan%2C+K+T%3BKarler%2C+R&rft.aulast=Finnegan&rft.aufirst=K&rft.date=1992-09-18&rft.volume=591&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-30 N1 - Date created - 1992-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prediction of Helicobacter pylori in gastric specimens by inflammatory and morphological histological evaluation. AN - 85226246; pmid-1519569 AB - Statistical correlations and predictive values were calculated for 330 gastrointestinal biopsies and tissues, of which 248 were from the stomach from 115 patients in this retrospective study, which graded 10 inflammatory and 14 morphological mucosal and submucosal abnormalities and compared them with the presence of Helicobacter pylori. Analysis revealed that 78 (31.5%) of the 248 stomach biopsies and tissues showed H. pylori, and 21 (8.5%) had non-Helicobacter-like bacteria, such as rods and cocci. Inflammatory components had high correlations, with specimens containing polymorphonuclear leukocytes (PMNs) showing high specificities and predictive values for a positive test, whereas the chronic inflammatory components had high sensitivities and predictive values for a negative test. Positive morphological correlations existed for mucus depletion, degeneration, regeneration, and ulceration, but intestinal metaplasia and adenocarcinoma had negative correlations. The antrum was most commonly infected, suggesting that intact healthy antral morphology and the neutral mucin in the surface epithelial cells represents the optimal environment for infection. Also, 8.5% of the gastric biopsies and tissues showed non-Helicobacter bacteria associated with inflammation, thus raising the question of colonization versus pathogenesis. JF - The American Journal of Gastroenterology AU - Hansing, R L AU - D'Amico, H AU - Levy, M AU - Guillan, R A AD - Department of Pathology and Surgery, Colmery-O'Neil Veterans Administration Hospital, Topeka, Kansas. PY - 1992 SP - 1125 EP - 1131 VL - 87 IS - 9 SN - 0002-9270, 0002-9270 KW - Helicobacter pylori KW - Human KW - Retrospective Studies KW - Aged KW - Predictive Value of Tests KW - Gastrointestinal System KW - Neutrophils KW - Aged, 80 and over KW - Adult KW - Mucous Membrane KW - Middle Age KW - Gastroenteritis KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Prediction+of+Helicobacter+pylori+in+gastric+specimens+by+inflammatory+and+morphological+histological+evaluation.&rft.au=Hansing%2C+R+L%3BD%27Amico%2C+H%3BLevy%2C+M%3BGuillan%2C+R+A&rft.aulast=Hansing&rft.aufirst=R&rft.date=1992-09-01&rft.volume=87&rft.issue=9&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanism and role of insulin receptor endocytosis. AN - 73431971; 1476159 AB - Like many other cell surface receptors for nutrients and polypeptide hormones, the insulin receptor undergoes a complex endocytotic itinerary. Upon insulin binding, the receptor is activated as a tyrosine-specific protein kinase and autophosphorylates. This autophosphorylation is necessary for the receptor to internalize. After endocytosis, the ligand (insulin) and its receptor are dissociated. Most of the insulin is degraded, whereas the receptors are largely recycled to the cell surface. The signals in the receptor that control and specify its endocytotic pathway are beginning to be understood. Through the techniques of in vitro mutagenesis, noninternalizing receptors have been engineered and their structural and functional properties have been analyzed. For example, the immediate submembranous domain of the insulin receptor has been found to contain sequences (Gly-Pro-Leu-Tyr and, to a lesser extent, Asn-Pro-Gln-Tyr) that are necessary for normal endocytosis. Receptors deleted or mutated in these sequences retain tyrosine kinase activity but fail to undergo endocytosis. Unlike the better understood low density lipoprotein and transferrin receptors, however, these sequences are not sufficient for endocytosis. An insulin receptor with only these sequences exposed in the cytoplasm does not internalize. Tyrosine kinase activity is thought to be needed to lead to autophosphorylation and a conformational change that exposes the otherwise buried endocytosis sequences in the normally dimerized insulin receptor. Non-internalizing mutants of the insulin receptor have been used to examine the role of endocytosis in insulin action. It was found that an endocytosis-defective receptor could induce a short-term metabolic action of insulin (glycogen synthetase stimulation) as well as longer-term mitogenic effects of insulin. Furthermore, insulin action deactivated after the hormone was removed from the noninternalizing receptors. Apparently, endocytosis is not necessary for insulin action, but probably is important for removing the insulin from the cell so the target cell for insulin responds in a time-limited fashion to the hormone. JF - The American journal of the medical sciences AU - McClain, D A AD - Veterans Administration Medical Center, Birmingham, Alabama 35213. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 192 EP - 201 VL - 304 IS - 3 SN - 0002-9629, 0002-9629 KW - Recombinant Proteins KW - 0 KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Down-Regulation KW - Transfection KW - Recombinant Proteins -- metabolism KW - Exons KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cell Line KW - Mutagenesis KW - Endocytosis KW - Receptor, Insulin -- genetics KW - Receptor, Insulin -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73431971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Mechanism+and+role+of+insulin+receptor+endocytosis.&rft.au=McClain%2C+D+A&rft.aulast=McClain&rft.aufirst=D&rft.date=1992-09-01&rft.volume=304&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-02 N1 - Date created - 1993-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital. AN - 73286906; 1409808 AB - Recent reports have indicated that the neurosteroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) interact with the GABAA receptor complex. Because many of the behavioral effects of ethanol and pentobarbital are due to activity at this complex, DHEA and DHEAS were tested for their ability to interact with the hypnotic and hypothermic effects of ethanol and pentobarbital. DHEA, but not DHEAS, causes a dose-dependent increase in the sleep time induced by either ethanol or pentobarbital. At 20 mg/kg, DHEA and DHEAS themselves cause a fall in body temperature. DHEA enhances the hypothermic effect of both ethanol and pentobarbital. DHEAS enhances the hypothermic effect of ethanol, but with pentobarbital it only delays the return of body temperature to baseline levels. Neither DHEA nor DHEAS affects the metabolism of ethanol. JF - Pharmacology, biochemistry, and behavior AU - Melchior, C L AU - Ritzmann, R F AD - Brentwood Division Research, West Los Angeles Veterans Administration, CA 90073. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 223 EP - 227 VL - 43 IS - 1 SN - 0091-3057, 0091-3057 KW - Hypnotics and Sedatives KW - 0 KW - Ethanol KW - 3K9958V90M KW - Dehydroepiandrosterone KW - 459AG36T1B KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Sleep -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - gamma-Aminobutyric Acid -- metabolism KW - Drug Synergism KW - Ethanol -- blood KW - Body Temperature -- drug effects KW - Ethanol -- pharmacology KW - Dehydroepiandrosterone -- pharmacology KW - Hypnotics and Sedatives -- pharmacology KW - Pentobarbital -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73286906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Dehydroepiandrosterone+enhances+the+hypnotic+and+hypothermic+effects+of+ethanol+and+pentobarbital.&rft.au=Melchior%2C+C+L%3BRitzmann%2C+R+F&rft.aulast=Melchior&rft.aufirst=C&rft.date=1992-09-01&rft.volume=43&rft.issue=1&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-02 N1 - Date created - 1992-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mental Health Status and Community Adjustment after Treatment in a Residential Treatment Program for Homeless Veterans AN - 61622841; 199301431 AB - To examine the relationship among psychiatric & substance abuse problems, community adjustment, & housing status in a sample of 255 homeless veterans, interview data were collected following treatment at programs in Fla, Ohio, & Calif. Program participation is found to be associated with improvement in all areas of mental health. However, this improvement is only weakly linked to improvement in other areas. 4 Tables, 16 References. E. Mortenson JF - The American Journal of Psychiatry AU - Leda, Catherine AU - Rosenheck, Robert AD - Northeast Program Evaluation Center West Haven Veterans Administration Medical Center, 950 Campbell Ave CT 06516 Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 1219 EP - 1224 VL - 149 IS - 9 SN - 0002-953X, 0002-953X KW - mental health status/community adjustment, postresidential treatment, homeless veterans KW - interviews KW - Florida/Ohio/California KW - Veterans KW - Treatment Outcomes KW - Substance Abuse KW - Residential Institutions KW - Mental Health KW - Mental Illness KW - Adjustment KW - Homelessness KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61622841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Mental+Health+Status+and+Community+Adjustment+after+Treatment+in+a+Residential+Treatment+Program+for+Homeless+Veterans&rft.au=Leda%2C+Catherine%3BRosenheck%2C+Robert&rft.aulast=Leda&rft.aufirst=Catherine&rft.date=1992-09-01&rft.volume=149&rft.issue=9&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Outcomes; Veterans; Homelessness; Adjustment; Mental Health; Substance Abuse; Mental Illness; Residential Institutions ER - TY - JOUR T1 - Cholinergic denervation alters [3H]phorbol-12,13-dibutyrate binding to rat hippocampal membranes. AN - 73173727; 1525667 AB - Cholinergic denervation of the rat hippocampus caused by electrolytic lesions of the medial septum (MS) results in a time-bound ingrowth of peripheral sympathetic noradrenergic fibers from the superior cervical ganglion to the dentate gyrus and CA3 region of the hippocampus. To determine the functional significance of hippocampal sympathetic ingrowth (HSI), [3H]phorbol-12,13-dibutyrate (PDBu) binding was assessed 4 weeks after MS lesions. In control animals, affinity for [3H]PDBu binding was found to be greater in the dorsal compared to ventral hippocampus, while the number of binding sites (Bmax) was similar between regions. Regardless of the presence of HSI, MS lesions resulted in increased affinity in the dorsal hippocampus, while the Bmax was found to 'normalize' in the ventral hippocampus by HSI. These results suggest that HSI is functional and can alter important cellular events. JF - Brain research AU - Ayyagari, V AU - Harrell, L E AD - Behavioral Neuroscience Program, Veterans Administration, Birmingham, AL. Y1 - 1992/08/07/ PY - 1992 DA - 1992 Aug 07 SP - 343 EP - 347 VL - 587 IS - 2 SN - 0006-8993, 0006-8993 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Ganglia, Parasympathetic -- cytology KW - Signal Transduction -- drug effects KW - In Vitro Techniques KW - Membranes -- metabolism KW - Ganglia, Parasympathetic -- metabolism KW - Denervation KW - Male KW - Parasympathetic Nervous System -- physiology KW - Hippocampus -- metabolism KW - Phorbol 12,13-Dibutyrate -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73173727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Cholinergic+denervation+alters+%5B3H%5Dphorbol-12%2C13-dibutyrate+binding+to+rat+hippocampal+membranes.&rft.au=Ayyagari%2C+V%3BHarrell%2C+L+E&rft.aulast=Ayyagari&rft.aufirst=V&rft.date=1992-08-07&rft.volume=587&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Production of both 92- and 72-kDa gelatinases by bone cells. AN - 73328281; 1435512 AB - We investigated the ability of murine bone organ cultures and osteoblast-like bone cells to produce 72- and 92-kDa gelatinase. 4-6 day newborn mouse calvaria cultures were found to release gelatinase activity into their conditioned medium (CM). This activity was increased by four stimulators of resorption, tumor necrosis factor alpha (TNF), interleukin-1 alpha (IL-1), parathyroid hormone (PTH) and the active phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). Both the 72- and 92-kDa forms of gelatinase were produced by murine bone cultures. In unstimulated bones 72-kDa gelatinase activity was approximately equal to that of the 92-kDa enzyme. IL-1, TNF, PTH and TPA all increased 92-kDa gelatinase activity in the CM of the bone cultures by about 2- to 2.5-fold. In addition TPA and IL-1 also increased 72-kDa gelatinase activity. In unstimulated osteoblast-like MC3T3-E1 cell cultures 72-kDa gelatinase enzyme activity was much greater than 92-kDa activity and was not substantially regulated (less than 40% change) by IL-1, TNF or PTH. In contrast, these agents stimulated 92-kDa gelatinase activity by 2- to 5-fold. As with the MC3T3-E1 cells, primary cells constitutively produced both 72-kDa and 92-kDa gelatinase. This was true for cells with both the most differentiated osteoblast-like phenotype (populations 3 and 4) and the least osteoblast-like phenotype (populations 1 and 2). In unstimulated cultures of all 4-primary populations, 92-kDa gelatinase production was less than 72-kDa and IL-1, TNF and PTH had only small effects on 72-kDa production in any of the populations (less than 60% change).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Matrix (Stuttgart, Germany) AU - Lorenzo, J A AU - Pilbeam, C C AU - Kalinowski, J F AU - Hibbs, M S AD - Department of Medicine, Veterans Administration Medical Center, Newington, CT 06111. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 282 EP - 290 VL - 12 IS - 4 SN - 0934-8832, 0934-8832 KW - Interleukin-1 KW - 0 KW - Matrix Metalloproteinase Inhibitors KW - Parathyroid Hormone KW - Tumor Necrosis Factor-alpha KW - Collagenases KW - EC 3.4.24.- KW - Metalloendopeptidases KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Interleukin-1 -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Mice KW - Skull -- cytology KW - Animals, Newborn KW - Parathyroid Hormone -- pharmacology KW - Skull -- enzymology KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Organ Culture Techniques KW - Osteoblasts -- drug effects KW - Osteoblasts -- enzymology KW - Bone and Bones -- enzymology KW - Collagenases -- biosynthesis KW - Metalloendopeptidases -- antagonists & inhibitors KW - Metalloendopeptidases -- biosynthesis KW - Bone and Bones -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73328281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Matrix+%28Stuttgart%2C+Germany%29&rft.atitle=Production+of+both+92-+and+72-kDa+gelatinases+by+bone+cells.&rft.au=Lorenzo%2C+J+A%3BPilbeam%2C+C+C%3BKalinowski%2C+J+F%3BHibbs%2C+M+S&rft.aulast=Lorenzo&rft.aufirst=J&rft.date=1992-08-01&rft.volume=12&rft.issue=4&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Matrix+%28Stuttgart%2C+Germany%29&rft.issn=09348832&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-02 N1 - Date created - 1992-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital. AN - 73158453; 1513842 AB - 3-alpha-Hydroxy-5-beta-pregnan-20-one [pregnanolone (PA)] and 3-beta-hydroxy-5-pregnen-20-one 3-sulfate [pregnenolone sulfate (PS)] are steroids that have been shown in biochemical studies to be active at the GABA-benzodiazepine-chloride receptor complex, Pa as a "barbiturate-like" agonist and PS as a "picrotoxin-like" antagonist. Since other compounds that are active at this site interact with the effects of pentobarbital and ethanol, the behavioral effects of these steroids alone and in combination with pentobarbital and ethanol were tested. Pa blocks the convulsions caused by pentylenetetrazole (PTZ) and increases motor activity when given alone in low doses. In combination with either pentobarbital or ethanol, it enhances the depression in motor activity, hypothermia, and hypnosis. In contrast, PS has no effect on PTZ convulsions and depresses motor activity by itself. With pentobarbital, PS enhances the depression in motor activity but has no effect on hypothermia or hypnosis. With ethanol, PS enhances the hypothermia but does not affect motor activity or hypnosis. Therefore, Pa and PS show different but not opposite effects in interacting with compounds active at the GABA-benzodiazepine-chloride receptor complex. JF - Pharmacology, biochemistry, and behavior AU - Melchior, C L AU - Allen, P M AD - Brentwood Research Service, West Los Angeles Veterans Administration Medical Center, CA 90073. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 605 EP - 611 VL - 42 IS - 4 SN - 0091-3057, 0091-3057 KW - Ethanol KW - 3K9958V90M KW - Pregnenolone KW - 73R90F7MQ8 KW - Pregnanolone KW - BXO86P3XXW KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Sleep -- drug effects KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Motor Activity -- drug effects KW - Mice KW - Seizures -- prevention & control KW - Time Factors KW - Male KW - Pregnenolone -- pharmacology KW - Ethanol -- pharmacology KW - Pregnanolone -- pharmacology KW - Pentobarbital -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73158453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Interaction+of+pregnanolone+and+pregnenolone+sulfate+with+ethanol+and+pentobarbital.&rft.au=Melchior%2C+C+L%3BAllen%2C+P+M&rft.aulast=Melchior&rft.aufirst=C&rft.date=1992-08-01&rft.volume=42&rft.issue=4&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-25 N1 - Date created - 1992-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aging of FRTL-5 rat thyroid cells causes sensitivity to cytotoxicity induced by tumor necrosis factor-alpha. AN - 73083878; 1322286 AB - While investigating the modulation of the growth and function of the FRTL-5 rat thyroid cell line by recombinant human tumor necrosis factor-alpha (TNF alpha), we noticed that pronounced changes in several response parameters occurred with increasing passage number. For young cells (passage less than 20), TNF alpha by itself slightly increased [3H]thymidine incorporation and DNA content, and had a minimal effect on basal 125I uptake. When combined with TSH, TNF alpha had no influence on TSH-stimulated [3H]thymidine incorporation, but significantly inhibited TSH-stimulated 125I uptake. Compared with young cells, aged cells (passage greater than 40), in contrast, developed a high sensitivity to TNF alpha. TNF alpha markedly stimulated [3H]thymidine incorporation into DNA, inhibited TSH-stimulated 125I uptake per micrograms DNA, but dramatically decreased the total DNA content and cell number. TSH augmented the TNF alpha effect in aged cells, resulting in a further reduction of DNA content. Aphidicolin, a specific inhibitor of DNA polymerase-alpha which is associated with DNA replication, dramatically inhibited TNF alpha-induced [3H]thymidine incorporation in both young and aged cells; this suggested that the effect of TNF alpha on FRTL-5 cell growth is related to DNA replication, rather than DNA repair. 51Cr release from FRTL-5 cells, a measure of cytotoxicity, increased 2-fold over baseline in aged cells at a dose of 400 ng/ml TNF alpha and decreased to 70% of baseline in young cells at this same dose. The protein kinase-A (PKA) and protein kinase-C (PKC) signal transduction mechanisms of TNF alpha in aged cells (passage greater than 40) were also studied. TNF alpha increased cAMP and also increased relative PKA and PKC activity in 1-40 min. Phorbol myristate acetate (PMA), an activator of PKC, increased [3H]thymidine incorporation and DNA content. PMA did not affect the TNF alpha-induced increase in [3H]thymidine incorporation or its reduction of DNA content. When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC. We conclude that the sensitivity of FRTL-5 cells to the cytotoxic effect of TNF alpha increases with aging. JF - Endocrinology AU - Chen, G AU - Pekary, A E AU - Hershman, J M AD - Endocrinology Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 863 EP - 870 VL - 131 IS - 2 SN - 0013-7227, 0013-7227 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Aphidicolin KW - 38966-21-1 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Protein Kinase C -- metabolism KW - Protein Kinases -- metabolism KW - Aphidicolin -- pharmacology KW - Animals KW - Thyrotropin -- pharmacology KW - Humans KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - DNA -- biosynthesis KW - DNA Replication -- drug effects KW - Cell Line KW - Thyroid Gland -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Cell Aging -- physiology KW - Thyroid Gland -- cytology KW - Cell Survival -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73083878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Aging+of+FRTL-5+rat+thyroid+cells+causes+sensitivity+to+cytotoxicity+induced+by+tumor+necrosis+factor-alpha.&rft.au=Chen%2C+G%3BPekary%2C+A+E%3BHershman%2C+J+M&rft.aulast=Chen&rft.aufirst=G&rft.date=1992-08-01&rft.volume=131&rft.issue=2&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-02 N1 - Date created - 1992-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction. AN - 73071448; 1322272 AB - We studied the role of the carboxyl-terminus of the extracellular region of the human TSH receptor in signal transduction (cAMP generation). For this purpose, we introduced homologous substitutions of smaller segments within amino acids 261-418 (domains D and E) of the TSH receptor with the corresponding amino acids of the rat LH/CG receptor. Amino acids 317-366 were not investigated in view of previous data indicating their noninvolvement. Mutant TSH receptor cDNAs, in a eukaryotic expression vector, were stably transfected into Chinese hamster ovary cells. Eight of nine plasmid constructs expressed TSH receptors that could be detected by radiolabeled TSH binding; six of these were of high affinity similar to the wild-type receptor and, therefore, provided informative data on signal transduction. Despite high affinity TSH binding, five of six TSH receptor mutants displayed a diminished cAMP response to TSH stimulation, suggesting the involvement of broad segments of domains DE in signal transduction. Amino acids 270-278 and 287-297 were particularly important in this respect. The conformation conferred by these segments of the TSH receptor, therefore, appears to be involved in transducing a signal from the extracellular to the intracellular region of the receptor. JF - Endocrinology AU - Nagayama, Y AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 548 EP - 552 VL - 131 IS - 2 SN - 0013-7227, 0013-7227 KW - Autoantibodies KW - 0 KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cyclic AMP -- biosynthesis KW - Humans KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Rats KW - Transfection KW - Molecular Sequence Data KW - CHO Cells KW - Thyrotropin -- metabolism KW - Graves Disease -- immunology KW - Cricetinae KW - Signal Transduction -- physiology KW - Receptors, Thyrotropin -- chemistry KW - Receptors, Thyrotropin -- physiology KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73071448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Role+of+the+carboxyl-terminal+half+of+the+extracellular+domain+of+the+human+thyrotropin+receptor+in+signal+transduction.&rft.au=Nagayama%2C+Y%3BRapoport%2C+B&rft.aulast=Nagayama&rft.aufirst=Y&rft.date=1992-08-01&rft.volume=131&rft.issue=2&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-02 N1 - Date created - 1992-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spectrum of injury produced in the duodenum by perfusion with luminal acid in the rat. AN - 73056449; 1634066 AB - The dose and time dependence of duodenal mucosal injury by luminal acid perfusion was studied. Saline, 0.01, 0.05, 0.15, and 0.3N HCl, were perfused through the proximal duodena of rats for 5, 15, or 30 minutes and then harvested for histological examination. In a second set of studies, after a 30-minute perfusion, duodena were harvested either immediately or 2, 4, 8, or 24 hours after the perfusion to study the recovery from injury. Acid disappearance (acid delivered minus acid recovered) was measured in all groups. Duodena were examined grossly, then fixed, stained, and scored histologically. Whereas no gross mucosal injury was noted, there was graded histological injury proportional to acid concentration. Injury occurred early in the perfusion and changed little with increased perfusion durations. The initial injury lead to an acid disappearance rate that was proportional to acid concentration and, therefore, the degree of injury. After the initial injury occurred, the rate of acid neutralization was unchanged by increased duration of acid perfusion. This acid neutralization protected against further injury despite the continued presence of acid. Recovery from injury was complete with physiological (0.01 and 0.05N HCl) but not pharmacological (0.15 and 0.3N HCl) concentrations of acid. It is concluded that acid-induced duodenal injury occurs within 5 minutes of exposure, is proportional to the acid concentration, and results in acid neutralization that protects against extension of the injury with continued acid exposure. JF - Gastroenterology AU - Livingston, E H AU - Passaro, E P AU - Miller, J AU - Guth, P H AD - Surgical Service, West Los Angeles Veterans Administration Medical Center, California. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 481 EP - 489 VL - 103 IS - 2 SN - 0016-5085, 0016-5085 KW - Hydrochloric Acid KW - QTT17582CB KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Male KW - Duodenum -- drug effects KW - Hydrochloric Acid -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73056449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Spectrum+of+injury+produced+in+the+duodenum+by+perfusion+with+luminal+acid+in+the+rat.&rft.au=Livingston%2C+E+H%3BPassaro%2C+E+P%3BMiller%2C+J%3BGuth%2C+P+H&rft.aulast=Livingston&rft.aufirst=E&rft.date=1992-08-01&rft.volume=103&rft.issue=2&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-25 N1 - Date created - 1992-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Psychotherapist as Witness for the Prosecution: The Criminalization of Tarasoff AN - 61302154; 93Z8203 AB - The California Supreme Court decision in 1976 in Tarasoff v. Regents of the University of California established the "duty to protect" doctrine, obligating mental health professionals to disclose information about their clients if they thought a third party might be in danger. In another case, a court deemed that certain clinical sessions were not psychotheraphy, & hence not confidential. Analyzed here are three cases in which mental health professionals served as prosecution witnesses, violating psychotherapist-patient privilege. The harmful effects of the erosion of confidentiality are indicated, eg, threat to professionals, & professionals' refraining from treating difficult patients. 21 References. I. Shagrir JF - The American Journal of Psychiatry AU - Leong, Gregory B AU - Eth, Spencer AU - Silva, J Arturo AD - West Los Angeles Veterans Administration Medical Center, 11301 Wilshire Blvd CA 90073 Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 1011 EP - 1015 VL - 149 IS - 8 SN - 0002-953X, 0002-953X KW - psychotherapist as prosecution witness, patient confidentiality issues KW - court cases KW - Therapists KW - Psychotherapy KW - Psychologists KW - Confidentiality KW - Judicial Decisions KW - Witnesses KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) KW - 1636: social control; sociology of law UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61302154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=The+Psychotherapist+as+Witness+for+the+Prosecution%3A+The+Criminalization+of+Tarasoff&rft.au=Leong%2C+Gregory+B%3BEth%2C+Spencer%3BSilva%2C+J+Arturo&rft.aulast=Leong&rft.aufirst=Gregory&rft.date=1992-08-01&rft.volume=149&rft.issue=8&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Confidentiality; Judicial Decisions; Psychologists; Therapists; Witnesses; Psychotherapy ER - TY - JOUR T1 - Chronic sodium azide treatment impairs learning of the Morris water maze task. AN - 73299595; 1417674 AB - A reduction in the activity of cytochrome oxidase, a respiratory chain enzyme, has been recently identified in mitochondria from blood platelets and postmortem brain tissue from Alzheimer's disease (AD) patients. We have developed an animal model of this deficit in rats by chronic subcutaneous infusion of sodium azide, a selective inhibitor of cytochrome oxidase, delivered via Alzet 2ML4 osmotic minipumps. In previous work, azide-treated rats were impaired in an appetitively motivated spatial learning task, the radial arm maze. In the present investigation, we tested male Sprague-Dawley rats (350-400 g), which were tonically infused with azide or saline, on an aversively motivated spatial task, the Morris water maze. Azide-treated rats were impaired on both acquisition and retention of this task, without showing evidence of a motor impairment. Thus, the present results are consistent with previous findings showing that chronic azide treatment produces a learning and memory deficit. These findings strengthen the hypothesis that azide treatment in rats produces a useful animal model of some aspects of AD. JF - Behavioral and neural biology AU - Bennett, M C AU - Rose, G M AD - Medical Research Service, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 72 EP - 75 VL - 58 IS - 1 SN - 0163-1047, 0163-1047 KW - Azides KW - 0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Space Perception -- drug effects KW - Injections, Subcutaneous KW - Retention (Psychology) -- drug effects KW - Learning -- drug effects KW - Male KW - Azides -- metabolism KW - Memory Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73299595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+neural+biology&rft.atitle=Chronic+sodium+azide+treatment+impairs+learning+of+the+Morris+water+maze+task.&rft.au=Bennett%2C+M+C%3BRose%2C+G+M&rft.aulast=Bennett&rft.aufirst=M&rft.date=1992-07-01&rft.volume=58&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+neural+biology&rft.issn=01631047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-04 N1 - Date created - 1992-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The potentiation of narcotic analgesics with phenothiazines. AN - 73229325; 1357024 AB - Potentiation of narcotic analgesics with phenothiazines have been used for preoperative and postoperative analgesia for a number of years by the podiatric community. The agents most frequently cited in studies are the combination of meperidine with either the phenothiazines chlorpromazine, trimeprazine, or promethazine. Due to the fact that the double-blind clinical studies of pain are mainly subjective, and difficult to quantify, the usefulness of phenothiazines for the sole purpose of potentiation of analgesia is questionable, especially in view of the many side effects of this group of drugs. JF - The Journal of foot surgery AU - Richter, P A AU - Burk, M P AD - James A. Haley Veterans Administration Hospital Podiatric Residency Program, Tampa, Florida. PY - 1992 SP - 378 EP - 380 VL - 31 IS - 4 SN - 0449-2544, 0449-2544 KW - Analgesics, Opioid KW - 0 KW - Phenothiazines KW - Meperidine KW - 9E338QE28F KW - Index Medicus KW - Meperidine -- pharmacology KW - Humans KW - Drug Synergism KW - Phenothiazines -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Phenothiazines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73229325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+foot+surgery&rft.atitle=The+potentiation+of+narcotic+analgesics+with+phenothiazines.&rft.au=Richter%2C+P+A%3BBurk%2C+M+P&rft.aulast=Richter&rft.aufirst=P&rft.date=1992-07-01&rft.volume=31&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+foot+surgery&rft.issn=04492544&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-03 N1 - Date created - 1992-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells. AN - 73014096; 1612026 AB - Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells. In the present work we studied the mechanism of TGF beta action in FRTL-5 rat thyroid cells. The cells were treated with TGF beta in the presence of TSH, growth factors, and cellular modulators for various periods of time; then, [3H]thymidine incorporation and DNA content were measured as indicators of DNA synthesis, and [125I]iodide uptake was measured to assess cell function. TGF beta (10 ng/ml) inhibited TSH-induced DNA synthesis and iodide uptake. TGF beta also inhibited DNA synthesis induced by insulin-like growth factor-I, fibroblast growth factor, and endothelial cell growth factor. The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation. The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate. The results show that activation of PKA or PKC increases DNA synthesis. TGF beta inhibited PKC-mediated, but not PKA-mediated, DNA synthesis in these cells. The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis. These findings suggest that TGF beta is a strong inhibitor of the proliferation and function of thyroid cells. JF - Endocrinology AU - Pang, X P AU - Park, M AU - Hershman, J M AD - Endocrine Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 45 EP - 50 VL - 131 IS - 1 SN - 0013-7227, 0013-7227 KW - Endothelial Growth Factors KW - 0 KW - Iodides KW - Transforming Growth Factor beta KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Protein Kinases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Endothelial Growth Factors -- pharmacology KW - Animals KW - Thyrotropin -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Fibroblast Growth Factors -- pharmacology KW - Insulin-Like Growth Factor I -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Cell Line KW - Protein Kinase C -- metabolism KW - Transforming Growth Factor beta -- pharmacology KW - Protein Kinases -- metabolism KW - Iodides -- metabolism KW - Thyroid Gland -- drug effects KW - DNA -- biosynthesis KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73014096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Transforming+growth+factor-beta+blocks+protein+kinase-A-mediated+iodide+transport+and+protein+kinase-C-mediated+DNA+synthesis+in+FRTL-5+rat+thyroid+cells.&rft.au=Pang%2C+X+P%3BPark%2C+M%3BHershman%2C+J+M&rft.aulast=Pang&rft.aufirst=X&rft.date=1992-07-01&rft.volume=131&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-27 N1 - Date created - 1992-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat. AN - 73013684; 1351857 AB - Expression of the proliferating cell nuclear antigen (PCNA) was examined in normal rat intestinal tissues and in carcinogen-treated nonneoplastic and neoplastic colonic mucosa. In the normal intestine, PCNA expression was confined to the expected region of the proliferative compartment. A strong correlation was observed between PCNA labeling index and both [3H]thymidine labeling index (R = 0.993, P = 0.007) and percent of cells in S phase as determined by flow cytometry (R = 0.982, P = 0.018) and between the location of the maximal staining for PCNA and [3H]thymidine (R = 0.997, P less than 0.05). In animals treated with dimethylhydrazine (DMH), crypt hyperplasia, an increased PCNA labeling index, and shifts in both the region of maximal and the upper extent of PCNA expression were observed during DMH exposure; significant crypt hyperplasia and expansion of the PCNA-positive compartment persisted after completion of DMH injections. The patterns of PCNA expression and bromodeoxyuridine incorporation were similar in DMH-induced tumors. It is concluded that PCNA immunohistochemistry can be used as a reliable marker of the proliferative compartment in both normal and neoplastic colonic mucosa. JF - Gastroenterology AU - Yamada, K AU - Yoshitake, K AU - Sato, M AU - Ahnen, D J AD - Department of Medicine, Denver Veterans Administration Medical Center, Colorado. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 160 EP - 167 VL - 103 IS - 1 SN - 0016-5085, 0016-5085 KW - Antigens, Neoplasm KW - 0 KW - Carcinogens KW - Dimethylhydrazines KW - Nuclear Proteins KW - Proliferating Cell Nuclear Antigen KW - 1,2-Dimethylhydrazine KW - IX068S9745 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Dimethylhydrazines -- pharmacology KW - Carcinogens -- pharmacology KW - Animals KW - Reference Values KW - Rats, Inbred F344 KW - Antigens, Neoplasm -- analysis KW - Tissue Distribution KW - Male KW - Nuclear Proteins -- analysis KW - Intestinal Mucosa -- immunology KW - Precancerous Conditions -- immunology KW - Colonic Neoplasms -- immunology KW - Colonic Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73013684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Proliferating+cell+nuclear+antigen+expression+in+normal%2C+preneoplastic%2C+and+neoplastic+colonic+epithelium+of+the+rat.&rft.au=Yamada%2C+K%3BYoshitake%2C+K%3BSato%2C+M%3BAhnen%2C+D+J&rft.aulast=Yamada&rft.aufirst=K&rft.date=1992-07-01&rft.volume=103&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-24 N1 - Date created - 1992-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sarcomas of the head and neck. Prognostic factors and treatment strategies. AN - 73009353; 1606539 AB - The authors reviewed 164 cases of head and neck sarcoma from adult patients seen at the University of California, Los Angeles (UCLA), between 1955 and 1988. The median follow-up was 70 months. Multivariate analysis demonstrated that tumor grade, size, and surgical margin status were the most important independent prognostic factors. Thirty-one percent (27 of 85) of patients with high-grade lesions were free of disease versus 81% (44 of 55) with low-grade lesions at last follow-up. Sixty-seven percent (50 of 76) of patients with lesions smaller than 5 cm were free of disease versus 38% (33 of 88) with lesions larger than 5 cm. In 16 patients, low-grade lesions, measuring less than 5 cm and with negative margins histologically, were controlled with surgery alone. For the 94 patients whose primary tumors were treated at UCLA, local control was achieved in 52% (26 of 50) of patients treated with surgery alone and 90% (20 of 22) with combined therapy (surgery and radiation therapy [RT] with or without chemotherapy). Seventy-five percent (6 of 8) of patients with positive surgical margins treated with postoperative RT achieved local control versus 26% (5 of 19) of patients receiving no additional treatment. In conclusion, surgery alone appears to be adequate treatment for small, low-grade tumors and negative surgical margins. Patients with incomplete resection or high-grade tumors should receive aggressive treatment--surgery and RT. JF - Cancer AU - Tran, L M AU - Mark, R AU - Meier, R AU - Calcaterra, T C AU - Parker, R G AD - Department of Radiation Therapy, Veterans Administration Wadsworth Medical Center, Los Angeles, CA 90073. Y1 - 1992/07/01/ PY - 1992 DA - 1992 Jul 01 SP - 169 EP - 177 VL - 70 IS - 1 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphatic Metastasis KW - Humans KW - Osteosarcoma -- pathology KW - Retrospective Studies KW - Hemangiopericytoma -- therapy KW - Hemangiopericytoma -- pathology KW - Fibrosarcoma -- mortality KW - Osteosarcoma -- mortality KW - Adult KW - Hemangiosarcoma -- pathology KW - Neoplasm Metastasis KW - Osteosarcoma -- therapy KW - Male KW - Combined Modality Therapy KW - Hemangiopericytoma -- mortality KW - Prognosis KW - Neurilemmoma -- pathology KW - Neurofibroma -- mortality KW - Fibrosarcoma -- pathology KW - Dose-Response Relationship, Radiation KW - Hemangiosarcoma -- therapy KW - Neurilemmoma -- mortality KW - Neurofibroma -- pathology KW - Neurilemmoma -- therapy KW - Fibrosarcoma -- therapy KW - Hemangiosarcoma -- mortality KW - Antineoplastic Agents -- therapeutic use KW - Neurofibroma -- therapy KW - Female KW - Head and Neck Neoplasms -- therapy KW - Sarcoma -- mortality KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Sarcoma -- therapy KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73009353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Sarcomas+of+the+head+and+neck.+Prognostic+factors+and+treatment+strategies.&rft.au=Tran%2C+L+M%3BMark%2C+R%3BMeier%2C+R%3BCalcaterra%2C+T+C%3BParker%2C+R+G&rft.aulast=Tran&rft.aufirst=L&rft.date=1992-07-01&rft.volume=70&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-21 N1 - Date created - 1992-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combat-Related Posttraumatic Stress Disorder and Severity of Substance Abuse in Vietnam Veterans AN - 61309358; 93Z8860 AB - Combat-exposed Vietnam-theater veterans (V-tVs) & Vietnam-era veterans (V-eVs) without war zone duty (N = 108 & 151, respectively) seeking treatment for substance abuse disorders in Seattle, Wash, were administered a battery of psychometric assessment measures, including one for posttraumatic stress disorder (PTSD). Analysis yielded no significant differences between V-tVs & V-eVs on alcoholism & drug abuse problems, but V-tVs suffering from PTSD scored significantly higher than non-PTSD V-tVs on several scales, & were at greater risk for concurrent alcohol & drug abuse disorders. The overall severity & ideational reexperiencing symptoms of PTSD were more strongly associated with drug than alcohol abuse, while the reverse was true for physiological arousal symptoms. These results confirm the hypothesis that substance abuse severity is associated more specifically with PTSD than with combat duty per se. Substance abuse becomes a maladaptive means of dealing with the cognitive & physiological symptoms of PTSD. 2 Tables, 30 References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - McFall, Miles E AU - Mackay, Priscilla W AU - Donovan, Dennis M AD - Veterans Administration Medical Center Psychology Service, 1660 South Columbian Way Seattle WA 98108 Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 357 EP - 363 VL - 53 IS - 4 SN - 0096-882X, 0096-882X KW - posttraumatic stress disorder/substance abuse, Vietnam-theater veterans KW - psychometric tests KW - substance abuse treatment clients, Seattle, Washington KW - Veterans KW - Substance Abuse KW - Treatment Programs KW - Vietnam War KW - Seattle, Washington KW - Posttraumatic Stress Disorder KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61309358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Combat-Related+Posttraumatic+Stress+Disorder+and+Severity+of+Substance+Abuse+in+Vietnam+Veterans&rft.au=McFall%2C+Miles+E%3BMackay%2C+Priscilla+W%3BDonovan%2C+Dennis+M&rft.aulast=McFall&rft.aufirst=Miles&rft.date=1992-07-01&rft.volume=53&rft.issue=4&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Vietnam War; Veterans; Substance Abuse; Seattle, Washington; Treatment Programs ER - TY - JOUR T1 - Possible substrates of ethanol reinforcement: GABA and dopamine. AN - 73057022; 1321582 JF - Annals of the New York Academy of Sciences AU - Harris, R A AU - Brodie, M S AU - Dunwiddie, T V AD - Denver Veterans Administration Medical Center, Colorado. Y1 - 1992/06/28/ PY - 1992 DA - 1992 Jun 28 SP - 61 EP - 69 VL - 654 SN - 0077-8923, 0077-8923 KW - Receptors, GABA-A KW - 0 KW - Ethanol KW - 3K9958V90M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Reward KW - Humans KW - Receptors, GABA-A -- physiology KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Reinforcement (Psychology) KW - Dopamine -- metabolism KW - gamma-Aminobutyric Acid -- metabolism KW - Alcoholism -- physiopathology KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73057022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Possible+substrates+of+ethanol+reinforcement%3A+GABA+and+dopamine.&rft.au=Harris%2C+R+A%3BBrodie%2C+M+S%3BDunwiddie%2C+T+V&rft.aulast=Harris&rft.aufirst=R&rft.date=1992-06-28&rft.volume=654&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-17 N1 - Date created - 1992-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of interleukin 2 production but not methionine adenosyltransferase activity or S-adenosylmethionine turnover in Jurkat T-cells. AN - 72985567; 1596894 AB - We have recently reported that methionine adenosyltransferase (MAT) in resting human peripheral blood T-cells is primarily present in the form of a precursor which we named lambda. This protein decreases upon cell stimulation, as both MAT activity and the amount of the catalytic alpha/alpha' subunits of the enzyme increase. When resting cells are activated by phytohemagglutinin, the decrease in lambda and increase in alpha/alpha' occurs after interleukin 2 (IL-2) production and before DNA synthesis. The human T-leukemia cell line, Jurkat, is unique in its ability to produce IL-2 in response to exogenous stimuli such as T-cell mitogens and therefore provides a convenient model for studying biochemical reactions involved in T-cell activation. In this study the regulation of MAT activity and S-adenosylmethionine (AdoMet) in resting and activated Jurkat cells was investigated. Here we report that MAT activity in unstimulated Jurkat cells is about 10- and 3-fold higher than the activity in resting and activated peripheral blood mononuclear cells, respectively. Activation of Jurkat cells with phytohemagglutinin resulted in increased IL-2-production, but not an increase in MAT activity. Identical results were obtained using freshly isolated cells from acute lymphoblastic leukemia patients. AdoMet utilization and pool size were approximately 3- and 10-fold higher, respectively, in Jurkat cells compared to peripheral blood mononuclear cells, and both parameters were unaffected by phytohemagglutinin stimulation. Jurkat MAT was determined to be structurally indistinguishable from enzyme from T- or B-leukemia cells but was different from resting, normal T-cells in that it lacked the lambda form. Furthermore, unlike MAT in resting T-cells, the relative amounts of the alpha, alpha', and beta subunits of the enzyme did not change throughout the course of IL-2 induction. We conclude that AdoMet metabolism and MAT activity in Jurkat cells are constitutively high and that induction of IL-2 synthesis in these cells is independent of changes in AdoMet synthesis or turnover. The lack of the lambda form and the difference in MAT regulation between leukemic T-cells and peripheral blood mononuclear cells may be exploited in the design of specific chemotherapeutic agents. JF - Cancer research AU - De La Rosa, J AU - Geller, A M AU - LeGros, H L AU - Kotb, M AD - Veterans Administration Medical Center, Research Service, Memphis, Tennessee 38104. Y1 - 1992/06/15/ PY - 1992 DA - 1992 Jun 15 SP - 3361 EP - 3366 VL - 52 IS - 12 SN - 0008-5472, 0008-5472 KW - Enzyme Precursors KW - 0 KW - Interleukin-2 KW - Phytohemagglutinins KW - Ionomycin KW - 56092-81-0 KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - Methionine Adenosyltransferase KW - EC 2.5.1.6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Lymphocyte Activation KW - Tumor Cells, Cultured KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Ionomycin -- pharmacology KW - Enzyme Precursors -- biosynthesis KW - Leukemia, T-Cell -- metabolism KW - S-Adenosylmethionine -- metabolism KW - Interleukin-2 -- biosynthesis KW - Methionine Adenosyltransferase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72985567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Induction+of+interleukin+2+production+but+not+methionine+adenosyltransferase+activity+or+S-adenosylmethionine+turnover+in+Jurkat+T-cells.&rft.au=De+La+Rosa%2C+J%3BGeller%2C+A+M%3BLeGros%2C+H+L%3BKotb%2C+M&rft.aulast=De+La+Rosa&rft.aufirst=J&rft.date=1992-06-15&rft.volume=52&rft.issue=12&rft.spage=3361&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-06 N1 - Date created - 1992-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Predictive value of objective esophageal insufflation testing for acquisition of tracheoesophageal speech. AN - 85194859; pmid-1602920 AB - This prospective study was undertaken to assess the predictive value of esophageal insufflation on the acquisition of tracheoesophageal (TE) speech. Fourteen total laryngectomy patients were evaluated prior to tracheoesophageal puncture (TEP) using objective esophageal pressure measurements. These patients then were followed prospectively for 6 to 13 months. Speech was assessed at the time of prosthesis fitting, at 1 month, at less than 6 months, and at greater than 6 months post-TEP. No patient underwent pharyngeal myotomy. Pre-TEP esophageal insufflation pressure was associated (P = .065) with successful TE speech at the time of prosthesis fitting, but was not associated with successful TE speech acquisition after 6 months. This study's results suggest that patients with poor pre-TEP esophageal insufflation test results will usually obtain successful TE speech given adequate time and training, even without pharyngeal myotomy. JF - The Laryngoscope AU - Callaway, E AU - Truelson, J M AU - Wolf, G T AU - Thomas-Kincaid, L AU - Cannon, S AD - Department of Speech Pathology, Veterans Administration Hospital, Ann Arbor, Mich. PY - 1992 SP - 704 EP - 708 VL - 102 IS - 6 SN - 0023-852X, 0023-852X KW - Esophagus KW - Probability KW - Voice Quality KW - Speech Intelligibility KW - Human KW - Aged KW - Rheology KW - Prospective Studies KW - Laryngectomy KW - Middle Age KW - Larynx, Artificial KW - Pressure KW - Speech KW - Time Factors KW - Phonation KW - Male KW - Female KW - Speech, Esophageal KW - Insufflation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85194859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Predictive+value+of+objective+esophageal+insufflation+testing+for+acquisition+of+tracheoesophageal+speech.&rft.au=Callaway%2C+E%3BTruelson%2C+J+M%3BWolf%2C+G+T%3BThomas-Kincaid%2C+L%3BCannon%2C+S&rft.aulast=Callaway&rft.aufirst=E&rft.date=1992-06-01&rft.volume=102&rft.issue=6&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Review of the experience with cefprozil for the treatment of lower respiratory tract infections. AN - 73039560; 1617044 AB - A regimen of cefprozil (500 mg twice daily), a new oral cephalosporin with a broad in vitro spectrum of antimicrobial activity, was compared to standard regimens of cefaclor (500 mg three times daily), cefuroxime axetil (500 mg twice daily), or amoxicillin/clavulanate (500 mg/125 mg three times daily) for the treatment of lower respiratory tract infections (mainly bronchitis and acute exacerbations of chronic bronchitis) in adults in three open-label, randomized trials. In the first trial, in which bacterial pathogens were isolated in initial cultures for only one-third of the patients, 90% of the pathogens were susceptible to cefprozil. A satisfactory clinical response was noted for 84% of the evaluable patients who received cefprozil versus 79% of those who received cefaclor for treatment of lower respiratory tract infections; rates of bacteriologic efficacy were 82% and 78%, respectively. In the second study rates of satisfactory clinical response were 96% with cefprozil and 83% with cefuroxime axetil (P less than .03) for treatment of bronchitis; the respective bacteriologic response rates were 100% and 92%. In the third trial, clinical efficacy was 91% for cefprozil and 87% for amoxicillin/clavulanate for treatment of bronchitis; bacteriologic efficacy was 95% and 96%, respectively. Tolerability and safety profiles were comparable, except that there was a higher rate of diarrhea among patients who received amoxicillin/clavulanate (P = .03). JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Pelletier, L L AD - Medical Service, Wichita Veterans Administration Medical Center, Kansas 67218. Y1 - 1992/06// PY - 1992 DA - June 1992 SP - S238 EP - 43; discussion S244-5 VL - 14 Suppl 2 SN - 1058-4838, 1058-4838 KW - Cephalosporins KW - 0 KW - Clavulanic Acids KW - cefprozil KW - 4W0459ZA4V KW - Cefaclor KW - 69K7K19H4L KW - Amoxicillin-Potassium Clavulanate Combination KW - 74469-00-4 KW - Amoxicillin KW - 804826J2HU KW - Cefuroxime KW - O1R9FJ93ED KW - Index Medicus KW - Acute Disease KW - Drug Therapy, Combination -- adverse effects KW - Cefaclor -- therapeutic use KW - Humans KW - Clavulanic Acids -- therapeutic use KW - Amoxicillin -- adverse effects KW - Amoxicillin -- therapeutic use KW - Cefuroxime -- adverse effects KW - Clavulanic Acids -- adverse effects KW - Cefuroxime -- therapeutic use KW - Drug Therapy, Combination -- therapeutic use KW - Cefaclor -- adverse effects KW - Cephalosporins -- adverse effects KW - Bronchitis -- drug therapy KW - Pneumonia, Pneumococcal -- drug therapy KW - Cephalosporins -- therapeutic use KW - Bronchopneumonia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73039560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Review+of+the+experience+with+cefprozil+for+the+treatment+of+lower+respiratory+tract+infections.&rft.au=Pelletier%2C+L+L&rft.aulast=Pelletier&rft.aufirst=L&rft.date=1992-06-01&rft.volume=14+Suppl+2&rft.issue=&rft.spage=S238&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-05 N1 - Date created - 1992-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Management and epidemiologic analyses of an outbreak due to methicillin-resistant Staphylococcus aureus. AN - 73021373; 1605142 AB - Following implementation of special measures to control a nosocomial outbreak of methicillin-resistant Staphylococcus aureus (MRSA), we used immunoblot typing in conjunction with antimicrobial susceptibility testing to investigate the epidemiology of this event and to determine whether this outbreak represented the failure of infection control measures to limit the spread of previously endemic MRSA strains or the introduction of a new strain of MRSA. Isolates of MRSA recovered from hospitalized patients were initially categorized on the basis of antimicrobial susceptibility results. Organisms susceptible to ciprofloxacin and/or trimethoprim/sulfamethoxazole were recovered from patients at a relatively constant rate prior to December 1988 and were categorized as endemic isolates. Subsequently, there was an outbreak due to organisms resistant to both of these antibiotics; these were therefore categorized as outbreak isolates. Isolates were later characterized by immunoblot typing. Prior to this analysis, isolates were given code numbers so that clinical and epidemiologic data as well as resistance patterns were not known until this testing was complete. Between January 1986 and November 1988, an average of 3.9 patients per month acquired nosocomial MRSA in the Sepulveda Veterans Administration Medical Center. In contrast, from December 1988 to October 1989, 369 MRSA isolates were collected from 125 patients (an average of 11.4 patients per month). Prior to December 1988, all tested nosocomial isolates of MRSA were susceptible to ciprofloxacin and/or to trimethoprim/sulfamethoxazole. In contrast, the outbreak was due to spread of MRSA isolates resistant to these antibiotics. Immunoblot typing of 204 isolates from 98 individuals identified five distinct immunoblot types of which types B and C were by far the most common. Type B was highly associated with outbreak isolates, whereas type C was associated with endemic isolates (p less than 0.001). All sequential isolates from single patients that belonged to different susceptibility categories demonstrated discordant immunoblot types. In contrast, concordant immunoblot types were observed for 25 of 27 sequential isolates that displayed minor variations in antimicrobial resistance. The institution of more stringent infection control measures was followed by the return of nosocomial MRSA acquisition rates to pre-outbreak levels. Although novobiocin and trimethoprim/sulfamethoxazole were extensively used to treat patients harboring outbreak and endemic isolates, respectively, in no instance was the initial MRSA isolate from any patient resistant to novobiocin and only 6% of initial endemic isolates displayed trimethoprim/sulfamethoxazole resistance. A modest, significant increase in the resistance of endemic isolates to various other antimicrobial agents was noted however. Immunoblot analyses provided strong, corroborative evidence that at least two separate strains of MRSA were present during the outbreak and that a newly introduced strain with a distinctive antimicrobial resistance pattern was primarily responsible for the rapid spread of MRSA during the outbreak. The observation that previously effective infection control measures failed to prevent the nosocomial spread of a newly introduced community-acquired MRSA strain suggests that a single set of control measures may not be equally efficacious against all strains of MRSA. In this regard, previously reported variations in resistance to topical antimicrobials and/or antiseptics, and differences in virulence factors such as colonization potential, invasiveness, and survival on fomites, may warrant further study. Control of the outbreak strain of MRSA in our institution did occur after the implementation of more strenuous isolation procedures.(ABSTRACT TRUNCATED) JF - The American journal of medicine AU - Goetz, M B AU - Mulligan, M E AU - Kwok, R AU - O'Brien, H AU - Caballes, C AU - Garcia, J P AD - Department of Medicine, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1992/06// PY - 1992 DA - June 1992 SP - 607 EP - 614 VL - 92 IS - 6 SN - 0002-9343, 0002-9343 KW - Novobiocin KW - 17EC19951N KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Organizational Policy KW - Humans KW - Trimethoprim, Sulfamethoxazole Drug Combination -- therapeutic use KW - Occupational Diseases -- prevention & control KW - Serotyping KW - Infection Control -- organization & administration KW - Evaluation Studies as Topic KW - Personnel, Hospital KW - Infection Control -- methods KW - Seasons KW - Trimethoprim Resistance KW - Incidence KW - Novobiocin -- therapeutic use KW - Occupational Diseases -- epidemiology KW - California -- epidemiology KW - Microbial Sensitivity Tests KW - Occupational Diseases -- microbiology KW - Prevalence KW - Hospitals, Veterans KW - Staphylococcal Infections -- epidemiology KW - Staphylococcal Infections -- prevention & control KW - Disease Outbreaks -- prevention & control KW - Carrier State -- prevention & control KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Methicillin Resistance KW - Disease Outbreaks -- statistics & numerical data KW - Staphylococcal Infections -- microbiology KW - Staphylococcus aureus KW - Carrier State -- epidemiology KW - Carrier State -- microbiology KW - Cross Infection -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73021373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Management+and+epidemiologic+analyses+of+an+outbreak+due+to+methicillin-resistant+Staphylococcus+aureus.&rft.au=Goetz%2C+M+B%3BMulligan%2C+M+E%3BKwok%2C+R%3BO%27Brien%2C+H%3BCaballes%2C+C%3BGarcia%2C+J+P&rft.aulast=Goetz&rft.aufirst=M&rft.date=1992-06-01&rft.volume=92&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-10 N1 - Date created - 1992-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preoperative combined chemotherapy and radiation therapy plus radical surgery in advanced head and neck cancer. Five-year results with impressive complete response rates and high survival. AN - 72913647; 1571903 AB - Radiation therapy combined with cisplatin as a chemoradiation sensitizer (CT/RT) has been reported to enhance tumor response in squamous cell carcinoma of the head and neck. In the present study, CT/RT was used preoperatively in advanced Stage III and IV head and neck cancer. Fifty-three patients were entered prospectively into a Phase II study. Treatment consisted of 4500 cGy of radiation therapy in 5 weeks combined with cisplatin 20 mg/m2 for 4 days during weeks 1 and 4 of radiation therapy. This was followed 4 to 8 weeks later by curative surgery. Pretherapy dental care; long-term nutritional support; individualized skin, mouth, and wound care; and continuous interdisciplinary communication were integral parts of this regimen. In four patients, CT/RT toxicity was seen (8%); three episodes of skin reaction or stomatitis and three episodes of leukopenia (less than 2500/microliters), causing a delay in CT/RT treatment in one patient. Three patients died of other causes during the preoperative interval, without clinical evidence of toxicity. Fifty patients (94%) had a complete (CR) or partial response (PR) to CT/RT. Clinical CR was seen in 38 of 51 (75%) primary tumors and 21 of 27 (78%) cervical nodes. Forty-one patients (77%) underwent curative surgery. In 27 of 32 (84%) resected CR primary tumors and 16 of 18 (89%) CR metastatic nodes, the surgical specimen was microscopically free of tumor. Postoperative morbidity was 32%. Five patients (12%) required additional surgery for their complications. Perioperative mortality was 5%. Five patients had tumor recurrence: three postoperatively after clinical PR to CT/RT and two in clinical CR patients who refused further treatment after CT/RT, then had a recurrence and were salvaged surgically. No patient with a CR in both the tumor and nodes who underwent surgery had a tumor recurrence. With a follow-up of 8 years (median, 40 months), the median survival for all patients was 45 months. The 5-year actuarial survival rate was 43% for all patients and 55% for patients who had CT/RT and surgery. This multimodality treatment of advanced head and neck cancer has low toxicity and impressive survival. It renders a significant number of patients tumor-free before surgery. These patients may be candidates for additional study triaging additional CT/RT for complete CR only and surgery for PR and biopsy-proved residual disease. JF - Cancer AU - Slotman, G J AU - Doolittle, C H AU - Glicksman, A S AD - Surgical Service, Providence Veterans Administration Medical Center, Rhode Island. Y1 - 1992/06/01/ PY - 1992 DA - 1992 Jun 01 SP - 2736 EP - 2743 VL - 69 IS - 11 SN - 0008-543X, 0008-543X KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Neoplasm Staging KW - Humans KW - Aged KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Survival Analysis KW - Cisplatin -- therapeutic use KW - Preoperative Care -- methods KW - Head and Neck Neoplasms -- therapy KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72913647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Preoperative+combined+chemotherapy+and+radiation+therapy+plus+radical+surgery+in+advanced+head+and+neck+cancer.+Five-year+results+with+impressive+complete+response+rates+and+high+survival.&rft.au=Slotman%2C+G+J%3BDoolittle%2C+C+H%3BGlicksman%2C+A+S&rft.aulast=Slotman&rft.aufirst=G&rft.date=1992-06-01&rft.volume=69&rft.issue=11&rft.spage=2736&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-04 N1 - Date created - 1992-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pantomime, Praxis, and Aphasia AN - 85551330; 9210157 AB - Pantomime productions of aphasic Ss (N = 30, mean age 61.1) with parietal & anterior left cerebral lesions were compared based on the site of lesion: frontal, temporoparietal, parietal, & frontotemporoparietal. All patients were administered the following batteries in this order: Pantomime Recognition Test (PRT), Transitive Pantomime Expression Test (TPET), Intransitive Pantomime Expression Test (IPET), Meaningful Movement Imitation Test (MMIT), & Nonmeaningful Movement Imitation Test (NMIT). All but the PRT were videotaped & scored. Ss were also assessed for general intellectual ability, language impairment, & reading comprehension. No significant differences were found between the four lesion groups, but a trend for best performance among the frontal group & worst performance among the parietal group was noted. Analysis indicates a strong correlation between all measures of pantomime production, recognition, & movement imitation; performance on both the TPET & IPET is correlated with the ability to imitate meaningless gestures; auditory comprehension is correlated with all measures of pantomime production & comprehension; & nonmeaningful imitation is not correlated to the language measures. Factor analysis shows that there is a strong common factor linking pantomiming, comprehension of pantomime movement, & imitation of meaningful & nonmeaningful movements. It is suggested that impaired use of pantomime among aphasic patients is due in part to both reduced symbolic capacity & apraxia. 5 Tables, 25 References. M. Lemons JF - Brain and Language AU - Wang, Lizhao AU - Goodglass, Harold AD - c/o Goodglass-Boston Veterans Administration Medical Center, 150 South Huntington Ave MA 02130 Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 402 EP - 418 VL - 42 IS - 4 SN - 0093-934X, 0093-934X KW - pantomime production ability comparison KW - pantomime tests KW - aphasics with parietal/anterior left cerebral lesions, mean age 61.1 KW - Imitation (34600) KW - Nonverbal Communication (58500) KW - Brain Damage (09400) KW - Aphasia (03400) KW - Comprehension (13950) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85551330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Pantomime%2C+Praxis%2C+and+Aphasia&rft.au=Wang%2C+Lizhao%3BGoodglass%2C+Harold&rft.aulast=Wang&rft.aufirst=Lizhao&rft.date=1992-05-01&rft.volume=42&rft.issue=4&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Brain Damage (09400); Nonverbal Communication (58500); Comprehension (13950); Imitation (34600) ER - TY - JOUR T1 - Gastroenterology today and tomorrow. AN - 85224617; pmid-1595640 JF - The American Journal of Gastroenterology AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. PY - 1992 SP - 559 EP - 561 VL - 87 IS - 5 SN - 0002-9270, 0002-9270 KW - United States KW - Reimbursement Mechanisms KW - Forecasting KW - Societies, Medical KW - Gastroenterology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Gastroenterology+today+and+tomorrow.&rft.au=Graham%2C+D+Y&rft.aulast=Graham&rft.aufirst=D&rft.date=1992-05-01&rft.volume=87&rft.issue=5&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A simplified method for the preparation of tetanus toxin binding fragment for neurobiology. AN - 73120465; 1380109 AB - The non-toxic binding fragment of tetanus toxin (fragment C) binds avidly to neural tissue and has a growing number of neurobiological uses. Its current utility is limited by both its high commercial cost and the complex procedure for its preparation requiring highly purified tetanus toxin. We have developed a short procedure which prepares fragments of tetanus toxin from crude C. tetani extracts. The resultant proteins are atoxic with molecular sizes and immunological properties closely resembling fragment C. These proteins undergo retrograde axonal and apparent transneuronal transport in a fashion similar to fragment C. JF - Journal of neuroscience methods AU - Fishman, P S AU - Farrand, D A AU - Halpern, J L AU - Latham, W C AD - Baltimore Veterans Administration Medical Center, MD. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 229 EP - 236 VL - 42 IS - 3 SN - 0165-0270, 0165-0270 KW - Antibodies, Monoclonal KW - 0 KW - Antigens KW - Neuromuscular Blocking Agents KW - Peptide Fragments KW - Tetanus Toxin KW - tetanus toxin fragment C KW - Index Medicus KW - Immunoblotting KW - Animals KW - Neurons -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - In Vitro Techniques KW - Hypoglossal Nerve -- anatomy & histology KW - Mice KW - Immunohistochemistry KW - Clostridium tetani KW - Antigens -- immunology KW - Molecular Weight KW - Axonal Transport KW - Antibodies, Monoclonal -- immunology KW - Tetanus Toxin -- immunology KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Tetanus Toxin -- metabolism KW - Tetanus Toxin -- chemistry KW - Peptide Fragments -- immunology KW - Neuromuscular Blocking Agents -- metabolism KW - Neuromuscular Blocking Agents -- immunology KW - Neuromuscular Blocking Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73120465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+methods&rft.atitle=A+simplified+method+for+the+preparation+of+tetanus+toxin+binding+fragment+for+neurobiology.&rft.au=Fishman%2C+P+S%3BFarrand%2C+D+A%3BHalpern%2C+J+L%3BLatham%2C+W+C&rft.aulast=Fishman&rft.aufirst=P&rft.date=1992-05-01&rft.volume=42&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+methods&rft.issn=01650270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-15 N1 - Date created - 1992-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of five preparations of synthetic monosodium urate monohydrate crystals. AN - 73025695; 1613710 AB - We conducted preliminary crystallographic investigations and biologic studies on 5 synthetically grown preparations of monosodium urate monohydrate (MSUM) crystals including one preparation of urate spherulites. The 5 crystal preparations exhibited wide variations in morphology, size, surface area, and ultrastructure, but only a few changes in their biologic effects. When injected intraarticularly, urate spherulites were less phlogistic than most acicular forms. Since crystal-cell interactions and inflammatory responses are influenced by crystal size, morphology, and surface characteristics, standardization of methods of preparing MSUM crystals is, therefore, important, particularly when analyzing and comparing results from different research laboratories. JF - The Journal of rheumatology AU - Fam, A G AU - Schumacher, H R AU - Clayburne, G AU - Sieck, M AU - Mandel, N S AU - Cheng, P T AU - Pritzker, K P AD - Veterans Administration Medical Center, Philadelphia, PA. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 780 EP - 787 VL - 19 IS - 5 SN - 0315-162X, 0315-162X KW - Uric Acid KW - 268B43MJ25 KW - Index Medicus KW - Crystallization KW - Phagocytosis -- physiology KW - X-Ray Diffraction KW - Leukocytes -- physiology KW - Inflammation -- chemically induced KW - Microscopy, Electron KW - Microscopy, Electron, Scanning KW - Uric Acid -- metabolism KW - Uric Acid -- adverse effects KW - Uric Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73025695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=A+comparison+of+five+preparations+of+synthetic+monosodium+urate+monohydrate+crystals.&rft.au=Fam%2C+A+G%3BSchumacher%2C+H+R%3BClayburne%2C+G%3BSieck%2C+M%3BMandel%2C+N+S%3BCheng%2C+P+T%3BPritzker%2C+K+P&rft.aulast=Fam&rft.aufirst=A&rft.date=1992-05-01&rft.volume=19&rft.issue=5&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-24 N1 - Date created - 1992-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitative and analytical studies in the diagnosis of mesothelioma. AN - 73019595; 1609158 AB - The vast majority of patients with malignant mesothelioma of the pleura or peritoneum have an abnormal tissue asbestos content as assessed by digestion techniques. These procedures allow for the quantification of asbestos bodies, as well as numbers and types of mineral fibers. In general, analyses of mineral fiber content correlate well with occupational exposure history. Such analyses are useful for the identification of asbestos-related mesotheliomas and separation from those due to other causes. JF - Seminars in diagnostic pathology AU - Roggli, V L AD - Department of Pathology, Durham Veterans Administration, NC. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 162 EP - 168 VL - 9 IS - 2 SN - 0740-2570, 0740-2570 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Occupational Exposure -- adverse effects KW - Microscopy, Electron KW - Environmental Exposure -- adverse effects KW - Asbestos -- analysis KW - Mesothelioma -- diagnosis KW - Mesothelioma -- etiology KW - Asbestos -- adverse effects KW - Pleural Neoplasms -- etiology KW - Pleural Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73019595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+diagnostic+pathology&rft.atitle=Quantitative+and+analytical+studies+in+the+diagnosis+of+mesothelioma.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1992-05-01&rft.volume=9&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Seminars+in+diagnostic+pathology&rft.issn=07402570&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-23 N1 - Date created - 1992-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels. AN - 72988830; 1603084 AB - Fibroblasts represent one of the in vivo sites of insulin-like growth factor-I (IGF-I) production. In this study rat dermal fibroblasts in culture were used as a model system to assess the effect of activation of protein kinase-C on the levels of the mRNAs encoding IGF-I and another growth factor, basic fibroblast growth factor (bFGF). IGF-I and bFGF mRNA levels were determined using a solution hybridization/RNase protection assay. Treatment of cells in serum-free medium containing 0.25% BSA (MEM + BSA) with the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) decreased IGF-I and increased bFGF mRNA levels in a time- and dose-dependent fashion. The peak effect of 100 nM PMA on IGF-I mRNA levels occurred at 9 h, whereas the peak effect on bFGF mRNA levels occurred after 3 h of incubation. In dose-response studies, half-maximal inhibition of IGF-I mRNA levels was achieved with approximately 0.08 nM PMA, while half-maximal stimulation of bFGF mRNA levels was achieved with approximately 3 nM PMA. Inhibition of protein synthesis with cycloheximide abrogated the effect of PMA on bFGF mRNA levels, but only partially inhibited the effect of PMA on IGF-I mRNA levels. Studies employing sphingosine or staurosporine to inhibit protein kinase-C or preincubation in high doses of PMA to down-regulate protein kinase-C suggested that the effect of PMA on IGF-I and bFGF mRNA levels was mediated by activation of protein kinase-C, although both staurosporine and sphingosine had independent effects on the levels of these mRNAs and down-regulation of protein kinase-C had a sustained effect on IGF-I mRNA levels. Ligands known to activate protein kinase-C were then tested. Treatment of cells with 100 micrograms/ml of the synthetic diacylglycerol 1-oleoyl-2-acetyl-sn-glycerol decreased IGF-I mRNA levels to 25% and increased bFGF mRNA levels to 520% of the level present in cells maintained in MEM + BSA. Treatment of cells with thrombin or bradykinin also decreased IGF-I mRNA levels and increased bFGF mRNA levels, but whereas the effect of thrombin on IGF-I mRNA levels was marked, the effect of bradykinin was minimal, and whereas the effect of thrombin on bFGF mRNA levels was sustained, the effect of bradykinin was transient.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Molecular endocrinology (Baltimore, Md.) AU - Lowe, W L AU - Yorek, M A AU - Karpen, C W AU - Teasdale, R M AU - Hovis, J G AU - Albrecht, B AU - Prokopiou, C AD - Department of Internal Medicine, University of Iowa College of Medicine, Veterans Administration Medical Center, Iowa City. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 741 EP - 752 VL - 6 IS - 5 SN - 0888-8809, 0888-8809 KW - RNA, Messenger KW - 0 KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Thrombin KW - EC 3.4.21.5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Rats KW - Animals KW - Thrombin -- pharmacology KW - In Vitro Techniques KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation KW - Bradykinin -- pharmacology KW - Fibroblasts -- metabolism KW - RNA, Messenger -- biosynthesis KW - Insulin-Like Growth Factor I -- genetics KW - Fibroblast Growth Factor 2 -- genetics KW - Protein Kinase C -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72988830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Activation+of+protein+kinase-C+differentially+regulates+insulin-like+growth+factor-I+and+basic+fibroblast+growth+factor+messenger+RNA+levels.&rft.au=Lowe%2C+W+L%3BYorek%2C+M+A%3BKarpen%2C+C+W%3BTeasdale%2C+R+M%3BHovis%2C+J+G%3BAlbrecht%2C+B%3BProkopiou%2C+C&rft.aulast=Lowe&rft.aufirst=W&rft.date=1992-05-01&rft.volume=6&rft.issue=5&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-16 N1 - Date created - 1992-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic/semichronic limbic epilepsy produced by microinjection of tetanus toxin in cat hippocampus. AN - 72962199; 1592013 AB - We describe an animal preparation in which a semichronic or chronic limbic epileptiform syndrome can be produced reliably by unilateral microinjection of tetanus toxin in cat ventral hippocampus. Injections were given at 1-week intervals until abnormal EEG activity was observed. After two to five injections, the animals abruptly began to exhibit intermittent spikes and subclinical discharges that soon gave way to spontaneous and recurrent behavioral seizures which gradually increased in frequency, duration, and severity in the next 12-48 h. Anticonvulsant therapy (phenobarbital, PB) was required within the first 3 days of the syndrome, since life-threatening generalized tonic-clonic seizures (GTCS) and status epilepticus would develop if the animal were left untreated. If severe seizures were prevented by antiepileptic drugs (AEDs) there was complete remission of the syndrome and repeat injection was necessary to reinitiate seizures. Animals that experienced severe seizures or that were reinjected after remission developed a chronic seizure syndrome and could be maintained with AEDs for long times (greater than 1 year) without significant debilitation. Although early spikes and subclinical discharges were typically focal to ipsilateral limbic sites, initial seizures appeared explosively in the form of a high-amplitude, high-frequency discharge, which often had an apparently bilateral limbic onset. On the other hand, chronic seizures had much more gradual onset and spread, often consisting of periodic sharp waves or low-amplitude sinusoidal discharge that was more clearly focal to ipsilateral limbic sites. Throughout the syndrome, ictal behavioral manifestations were highly stereotyped and very comparable to those described by other investigators in studies of clinical and experimental limbic epilepsy. All animals exhibited signs of independent contralateral involvement during the syndrome, ranging from independent contralateral spikes to subclinical discharges with a clear contralateral onset. None of the animals exhibited structural lesions on histologic examination at the level of light microscopy. JF - Epilepsia AU - Darcey, T M AU - Williamson, P D AD - Neurology Service, Veterans Administration Medical Center, West Haven, Connecticut. PY - 1992 SP - 402 EP - 419 VL - 33 IS - 3 SN - 0013-9580, 0013-9580 KW - Tetanus Toxin KW - 0 KW - Index Medicus KW - Epilepsy, Temporal Lobe -- physiopathology KW - Animals KW - Amygdala -- physiopathology KW - Electroencephalography KW - Cats KW - Models, Neurological KW - Microinjections KW - Female KW - Stereotaxic Techniques KW - Limbic System -- physiopathology KW - Epilepsies, Partial -- physiopathology KW - Tetanus Toxin -- administration & dosage KW - Epilepsies, Partial -- chemically induced KW - Disease Models, Animal KW - Tetanus Toxin -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72962199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Chronic%2Fsemichronic+limbic+epilepsy+produced+by+microinjection+of+tetanus+toxin+in+cat+hippocampus.&rft.au=Darcey%2C+T+M%3BWilliamson%2C+P+D&rft.aulast=Darcey&rft.aufirst=T&rft.date=1992-05-01&rft.volume=33&rft.issue=3&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-01 N1 - Date created - 1992-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin E in the treatment of chemotherapy-induced mucositis. AN - 72936004; 1580295 AB - To determine the efficacy of vitamin E in the treatment of chemotherapy-induced mucositis in patients with malignancy. A randomized, double-blind, placebo-controlled study was performed to evaluate the efficacy of topical vitamin E in the treatment of oral mucositis in patients receiving chemotherapy for various types of malignancy. A total of 18 patients, 17 of whom had solid tumors and one with acute leukemia, were included in this study. Lesions were observed daily prior to and 5 days after topical application of either vitamin E or placebo oil. Six of nine patients receiving vitamin E had complete resolution of their oral lesions. In eight of nine patients who received placebo, complete resolution of their oral lesions was not observed. This difference is statistically significant (p = 0.025 by Fisher's exact test). No toxicity was observed in this study. These results suggest that vitamin E may be an effective therapy in patients with chemotherapy-induced mucositis. JF - The American journal of medicine AU - Wadleigh, R G AU - Redman, R S AU - Graham, M L AU - Krasnow, S H AU - Anderson, A AU - Cohen, M H AD - Division of Medical Oncology, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 481 EP - 484 VL - 92 IS - 5 SN - 0002-9343, 0002-9343 KW - Antineoplastic Agents KW - 0 KW - Vitamin E KW - 1406-18-4 KW - Abridged Index Medicus KW - Index Medicus KW - Mouth Mucosa KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Administration, Topical KW - Stomatitis -- chemically induced KW - Vitamin E -- therapeutic use KW - Stomatitis -- drug therapy KW - Vitamin E -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72936004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Vitamin+E+in+the+treatment+of+chemotherapy-induced+mucositis.&rft.au=Wadleigh%2C+R+G%3BRedman%2C+R+S%3BGraham%2C+M+L%3BKrasnow%2C+S+H%3BAnderson%2C+A%3BCohen%2C+M+H&rft.aulast=Wadleigh&rft.aufirst=R&rft.date=1992-05-01&rft.volume=92&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-11 N1 - Date created - 1992-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. AN - 72911544; 1567206 AB - Previous work suggested that the oxidation of uroporphyrinogen to uroporphyrin is catalyzed by cytochrome P450IA2. Here we determined whether purified reconstituted mouse P450IA1 and IA2 oxidize uroporphyrinogen. Cytochromes P450IA1 and IA2 were purified from hepatic microsomes from 3-methylcholanthrene (MC)-treated C57BL/6 mice, using a combination of affinity chromatography and high performance liquid chromatography. Reconstituted P450IA1 was more active than P450IA2 in catalyzing ethoxyresorufin-O-deethylase (EROD) activity, whereas P450IA2 was more active than P450IA1 in catalyzing uroporphyrinogen oxidation (UROX). Both reactions required NADPH, NADPH-cytochrome P450 reductase, and either P450IA1 or IA2. Ketoconazole competitively inhibited both EROD and UROX activities, in microsomes from MC-treated mice. Ketoconazole also inhibited UROX catalyzed by reconstituted P450IA2. In contrast, ketoconazole did not inhibit UROX catalyzed by xanthine oxidase in the presence of iron-EDTA. Superoxide dismutase, catalase, and mannitol inhibited UROX catalyzed by xanthine oxidase/iron-EDTA, but did not affect UROX catalyzed by either microsomes or reconstituted P450IA2. These results suggest that UROX catalyzed by P450IA2 in microsomes and reconstituted systems does not involve free reactive oxygen species. Two known substrates of cytochrome P450IA2, 2-amino-3,4-dimethylimidazole[4,5-f]quinoline and phenacetin, were shown to inhibit the microsomal UROX reaction, suggesting that uroporphyrinogen binds to a substrate-binding site on the cytochrome P450. JF - Archives of biochemistry and biophysics AU - Lambrecht, R W AU - Sinclair, P R AU - Gorman, N AU - Sinclair, J F AD - Veterans Administration, White River Junction, Vermont 05009. Y1 - 1992/05/01/ PY - 1992 DA - 1992 May 01 SP - 504 EP - 510 VL - 294 IS - 2 SN - 0003-9861, 0003-9861 KW - Quinolines KW - 0 KW - Uroporphyrinogens KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxidoreductases KW - EC 1.- KW - Cytochrome P-450 CYP1A2 KW - EC 1.14.14.1 KW - Phenacetin KW - ER0CTH01H9 KW - 2-amino-3,4-dimethylimidazo(4,5-f)quinoline KW - G2Q7M1P33X KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Oxidation-Reduction KW - Phenacetin -- pharmacology KW - Animals KW - Quinolines -- pharmacology KW - Methylcholanthrene -- pharmacology KW - Kinetics KW - Mice, Inbred C57BL KW - Mice KW - Ketoconazole -- pharmacology KW - Male KW - Oxidoreductases -- isolation & purification KW - Oxidoreductases -- metabolism KW - Microsomes, Liver -- enzymology KW - Cytochrome P-450 Enzyme System -- isolation & purification KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Uroporphyrinogens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72911544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Uroporphyrinogen+oxidation+catalyzed+by+reconstituted+cytochrome+P450IA2.&rft.au=Lambrecht%2C+R+W%3BSinclair%2C+P+R%3BGorman%2C+N%3BSinclair%2C+J+F&rft.aulast=Lambrecht&rft.aufirst=R&rft.date=1992-05-01&rft.volume=294&rft.issue=2&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-15 N1 - Date created - 1992-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Central thyrotropin-releasing factor analog prevents ethanol-induced gastric damage through prostaglandins in rats. AN - 72907697; 1568566 AB - The effects of intracisternal injection of the stable thyrotropin-releasing factor (TRH) analog RX 77368 on gastric lesions induced by 60% ethanol and gastric prostaglandin E2 (PGE2) release were studied in rats. RX 77368 (1.0 and 1.5 ng) injected intracisternally inhibited (by 58% and 78%, respectively) macroscopic gastric damage induced by ethanol. Higher doses (3 and 300 ng) inhibited ethanol-induced gastric injury only in rats pretreated with omeprazole (20 mg/kg SC). Gastric acid output measured in conscious rats 2 hours after pylorus ligation was not modified by intracisternal injection of RX 77368 at 1.5 ng but was significantly increased by 54% at the 3-ng dose. The protective effect of TRH analog (1.5 ng) was completely abolished by indomethacin (5 mg/kg IP) and atropine (2 mg/kg SC) pretreatment. In pylorus-ligated rats, intracisternal RX 77368 (1.5 ng) inhibited ethanol-induced gastric lesions by 64%. Intracisternal injection of RX 77368 (1.5 ng) increased PGE2 levels measured in the effluent of dialysis fibers implanted into the corpus submucosa of urethane-anesthetized rats. Peripheral administration of omeprazole, atropine, indomethacin, or RX 77368 (1.5 ng IV) did not influence gastric damage induced by ethanol. These data show that the stable TRH analog, RX 77368, injected intracisternally at low non-secretory doses acts in the brain to protect against ethanol lesions through prostaglandin and cholinergic pathways. These findings suggest that central vagal activation induced by TRH may play a role in the control of mucosal integrity against ethanol through cholinergic prostaglandin release. JF - Gastroenterology AU - Yoneda, M AU - Taché, Y AD - Center for Ulcer Research and Education, Veterans Administration Medical Center, Los Angeles, California. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 1568 EP - 1574 VL - 102 IS - 5 SN - 0016-5085, 0016-5085 KW - Ethanol KW - 3K9958V90M KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide KW - 76820-40-1 KW - Dinoprostone KW - K7Q1JQR04M KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Vagus Nerve -- physiology KW - Vagus Nerve -- drug effects KW - Pyrrolidonecarboxylic Acid -- analogs & derivatives KW - Male KW - Gastric Acid -- secretion KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Thyrotropin-Releasing Hormone -- analogs & derivatives KW - Brain -- drug effects KW - Ethanol -- toxicity KW - Dinoprostone -- secretion KW - Gastric Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72907697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Central+thyrotropin-releasing+factor+analog+prevents+ethanol-induced+gastric+damage+through+prostaglandins+in+rats.&rft.au=Yoneda%2C+M%3BTach%C3%A9%2C+Y&rft.aulast=Yoneda&rft.aufirst=M&rft.date=1992-05-01&rft.volume=102&rft.issue=5&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-27 N1 - Date created - 1992-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells. AN - 72907679; 1569190 AB - Colo 320 cells are colonic carcinoma cells known to express abundant c-myc mRNA. Based on the response of several hematopoietic cell lines to chemical inducers of differentiation, we reasoned that such agents might have similar inductive activity in Colo 320 cells. Accordingly, we exposed Colo 320 cells to 5 mM sodium butyrate (NaBT) for 7 d. C-myc expression decreased threefold and self-replicative potential decreased (defined as a greater than 60% decrease in colony-forming capacity in soft agar that did not contain inducer). In an effort to demonstrate a direct cause and effect between myc expression and the colony-forming capacity of Colo 320 cells, we exposed these cells to a 15-base antisense c-myc oligonucleotide (complementary to the translation initiation region of exon II). Cells were also exposed to equimolar (20 microM) amounts of sense and missense oligonucleotides. Subsequently, cells were incubated at 10, 20, 30, and 40 microM antisense DNA for 16 h, then washed and plated in oligonucleotide-free agar medium. We demonstrated that: (a) the oligomers were stable in the extracellular medium and in the cell cytoplasm; (b) the uptake of the oligonucleotides was 0.7%; (c) sense and missense oligonucleotides had no effect on colony-forming capacity; and (d) the antisense c-myc oligonucleotide resulted in a 40-75% concentration-dependent decrease in colony-forming capacity. The specific inhibition of colony-forming capacity by antisense DNA suggests that the role of myc expression in Colo 320 cells is similar to its role in hematopoiesis, and that the failure to inhibit myc expression maintains colony-forming capacity. This system provides a new strategy for inducing differentiation and may provide further insight into the genetic factors that govern the process of colonic carcinogenesis. JF - The Journal of clinical investigation AU - Collins, J F AU - Herman, P AU - Schuch, C AU - Bagby, G C AD - Department of Medicine, Portland Veterans Administration Medical Center, Oregon 97207. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 1523 EP - 1527 VL - 89 IS - 5 SN - 0021-9738, 0021-9738 KW - Butyrates KW - 0 KW - Oligonucleotides, Antisense KW - RNA, Messenger KW - Butyric Acid KW - 107-92-6 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Tumor Cells, Cultured KW - Humans KW - Butyrates -- pharmacology KW - In Vitro Techniques KW - RNA, Messenger -- genetics KW - Cell Differentiation -- drug effects KW - Cell Division KW - Colonic Neoplasms -- genetics KW - Carcinoma -- pathology KW - Genes, myc KW - Colonic Neoplasms -- pathology KW - Carcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72907679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=c-myc+antisense+oligonucleotides+inhibit+the+colony-forming+capacity+of+Colo+320+colonic+carcinoma+cells.&rft.au=Collins%2C+J+F%3BHerman%2C+P%3BSchuch%2C+C%3BBagby%2C+G+C&rft.aulast=Collins&rft.aufirst=J&rft.date=1992-05-01&rft.volume=89&rft.issue=5&rft.spage=1523&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-26 N1 - Date created - 1992-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 [6159641] J Biol Chem. 1987 Jan 25;262(3):1092-7 [3805014] Cancer Res. 1982 Mar;42(3):1052-8 [7059970] Cancer. 1980 Mar 15;45(5 Suppl):1178-84 [7357510] Cancer. 1980 Mar 15;45(5 Suppl):1238-42 [7357515] Histopathology. 1990 Apr;16(4):357-63 [1694512] Hum Pathol. 1987 Jan;18(1):9-21 [2434408] Lab Invest. 1985 Mar;52(3):243-56 [2579289] Biotechniques. 1988 Feb;6(2):114-6 [2908499] Gastroenterol Clin North Am. 1988 Dec;17(4):931-40 [3068151] Proc Natl Acad Sci U S A. 1988 Feb;85(4):1028-32 [3277186] Mol Cell Biol. 1988 Feb;8(2):963-73 [3280975] J Clin Invest. 1986 Jan;77(1):271-8 [3511091] Proc Natl Acad Sci U S A. 1986 Sep;83(17):6480-4 [3529085] Cancer Res. 1985 Feb;45(2):822-5 [3855381] Br J Haematol. 1986 Feb;62(2):287-92 [3947550] Am J Clin Pathol. 1981 Apr;75(4):581-4 [6261578] Am J Surg Pathol. 1983 Oct;7(7):643-51 [6314828] Mol Cell Biol. 1983 May;3(5):787-95 [6865942] Cancer Res. 1982 Nov;42(11):4540-5 [7127294] Cancer. 1980 Mar 15;45(5 Suppl):1185-92 [7357511] Arch Biochem Biophys. 1962 Mar;96:506-15 [13906951] Cancer Res. 1979 Dec;39(12):4914-24 [498117] Cell. 1991 May 31;65(5):715-6 [2040011] Cancer. 1988 Apr 1;61(7):1359-63 [2449944] Annu Rev Genet. 1986;20:361-84 [3028245] Int J Cancer. 1988 Jul 15;42(1):64-70 [3164710] Blood. 1987 Nov;70(5):1233-44 [3311197] Nature. 1986 Aug 21-27;322(6081):748-50 [3528861] Proc Natl Acad Sci U S A. 1983 Mar;80(6):1707-11 [6300869] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Does irradiation produce irreversible changes in canine jejunal myoelectric activity? AN - 72897797; 1563313 AB - We sought to determine whether acute irradiation-induced changes in jejunal myoelectric activity are reversible or chronic and progressive with repeated exposures. Five dogs underwent abdominal irradiation absorbing 938 cGy on four separate occasions, two weeks apart. Recordings of jejunal myoelectric activity were made before and 10-11 days after each irradiation exposure. Ten to 11 days after the first exposure, the animals recovered completely from the acute radiation syndrome, and the myoelectric activity returned to normal. After subsequent exposures, they developed chronic diarrhea, profound weight loss, and progressive changes in myoelectric activity. Slow waves exhibited highly variable configuration, had an irregular rhythm, and were frequently uncoupled. Spike burst activity, duration, and length of migration were reduced in association with abnormal motility patterns even though histologic abnormalities were mild. Such changes are likely to interfere with normal propulsion and contribute to impaired nutrition. The abnormalities suggest that irradiation causes dysfunction of one or more of the cellular elements involved in small bowel motility (muscle, nerve, and interstitial cells) prior to the development of severe histologic abnormalities or mechanical obstruction. JF - Digestive diseases and sciences AU - Summers, R W AU - Glenn, C E AU - Flatt, A J AU - Elahmady, A AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 716 EP - 722 VL - 37 IS - 5 SN - 0163-2116, 0163-2116 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Action Potentials -- physiology KW - Gastrointestinal Motility -- radiation effects KW - Gastrointestinal Motility -- physiology KW - Action Potentials -- radiation effects KW - Dogs KW - Dose-Response Relationship, Radiation KW - Radiation Injuries, Experimental -- physiopathology KW - Time Factors KW - Female KW - Myoelectric Complex, Migrating -- radiation effects KW - Jejunum -- radiation effects KW - Myoelectric Complex, Migrating -- physiology KW - Jejunum -- physiopathology KW - Muscle, Smooth -- radiation effects KW - Muscle, Smooth -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72897797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Does+irradiation+produce+irreversible+changes+in+canine+jejunal+myoelectric+activity%3F&rft.au=Summers%2C+R+W%3BGlenn%2C+C+E%3BFlatt%2C+A+J%3BElahmady%2C+A&rft.aulast=Summers&rft.aufirst=R&rft.date=1992-05-01&rft.volume=37&rft.issue=5&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-20 N1 - Date created - 1992-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bromocriptine treatment of nonfluent aphasia. AN - 85225352; pmid-1554312 AB - Two patients with nonfluent aphasia, secondary to stroke, of more than 18 months' duration, were started on bromocriptine to determine its effect on speech fluency. The first patient showed some improvement in fluency at 10 mg and marked improvement at 30 mg; he increased from a mean length of 3.19 words to 4.23 words per utterance. The second patient improved at 10 mg, got worse at 30 mg, and improved again at 10 mg; he increased again to 4.44 at 10 mg. Functionally, both of the patients, their families, and the hospital staff noticed marked improvement in producing multisyllable words and providing information in sentence form. Our results suggest that bromocriptine may be useful for improving fluency in some chronically nonfluent aphasic patients and that the optimum dose may vary from person to person. JF - Archives of Physical Medicine and Rehabilitation AU - Gupta, S R AU - Mlcoch, A G AD - Department of Neurology, Veterans Administration Hospital, Hines, IL 60141. PY - 1992 SP - 373 EP - 376 VL - 73 IS - 4 SN - 0003-9993, 0003-9993 KW - Language Tests KW - Bromocriptine KW - Cerebral Infarction KW - Dose-Response Relationship, Drug KW - Aphasia, Broca KW - Human KW - Speech Therapy KW - Aged KW - Middle Age KW - Case Report KW - Speech KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Bromocriptine+treatment+of+nonfluent+aphasia.&rft.au=Gupta%2C+S+R%3BMlcoch%2C+A+G&rft.aulast=Gupta&rft.aufirst=S&rft.date=1992-04-01&rft.volume=73&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - One more look at alcohol consumption and risk of coronary disease. AN - 72960417; 1590558 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Peña, J M AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 350 VL - 16 IS - 2 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Myocardial Infarction -- mortality KW - Coronary Disease -- mortality KW - Alcohol Drinking -- mortality KW - Alcoholism -- mortality KW - Alcohol Drinking -- adverse effects KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72960417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=One+more+look+at+alcohol+consumption+and+risk+of+coronary+disease.&rft.au=Gallant%2C+D+M%3BPe%C3%B1a%2C+J+M&rft.aulast=Gallant&rft.aufirst=D&rft.date=1992-04-01&rft.volume=16&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-22 N1 - Date created - 1992-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. AN - 72959927; 1592437 AB - Most research on the effects of ageing on gut mucosal immunity has been performed using rodents. However, there are inherent difficulties in the extrapolation of rodent data to humans. This study was initiated to define age-related changes in the gastrointestinal (GI) mucosal immune response in non-human primates. Antibody responses were measured in young and old rhesus monkeys (Macaca mulatta) immunized intraduodenally with cholera toxin (Ctx)/cholera toxoid (Ctd). Antigen-specific immunoglobulin A (IgA) antibody levels were markedly lower while anti-Ctx IgG and IgM titres were higher in the intestinal lavage samples of old as compared to young animals. Total IgA concentrations in gut lavage were independent of age or immune status. Measurable titres of anti-Ctx IgA in the saliva of both age groups support the common mucosal immune hypothesis. Flow cytometric analysis was used to identify age-related shifts in the expression of cell surface antigens on peripheral blood lymphocytes. The relative number of both IgA+ and Ctx+ cells was dramatically reduced in the blood of old monkeys. Collectively, these data suggest that the GI mucosal immune response to Ctx is compromised in old rhesus macaques. The deficit in immune responsiveness, namely reduced anti-Ctx IgA antibody secretion into the intestinal lumen, may be a consequence of alterations in the process of maturation and homing of specific antibody-secreting B lymphocytes. JF - Immunology AU - Taylor, L D AU - Daniels, C K AU - Schmucker, D L AD - Cell Biology and Aging, Veterans Administration Medical Center, University of California, San Francisco 94121. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 614 EP - 618 VL - 75 IS - 4 SN - 0019-2805, 0019-2805 KW - Antigens, Surface KW - 0 KW - Immunoglobulin A KW - Immunoglobulin G KW - Immunoglobulin M KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Saliva -- immunology KW - Animals KW - Cholera Toxin -- immunology KW - Macaca mulatta KW - Immunoglobulin M -- biosynthesis KW - Immunoglobulin G -- biosynthesis KW - Male KW - Female KW - Antigens, Surface -- analysis KW - Intestinal Mucosa -- immunology KW - Intestinal Mucosa -- metabolism KW - Immunoglobulin A -- biosynthesis KW - Aging -- immunology KW - Immunoglobulin A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72959927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Ageing+compromises+gastrointestinal+mucosal+immune+response+in+the+rhesus+monkey.&rft.au=Taylor%2C+L+D%3BDaniels%2C+C+K%3BSchmucker%2C+D+L&rft.aulast=Taylor&rft.aufirst=L&rft.date=1992-04-01&rft.volume=75&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-02 N1 - Date created - 1992-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunology. 1988 Aug;64(4):691-5 [3169843] J Immunol. 1973 Aug;111(2):395-403 [4197984] Gastroenterology. 1988 Jun;94(6):1432-40 [3360264] Methods Enzymol. 1984;108:88-102 [6527662] J Am Geriatr Soc. 1986 May;34(5):377-84 [3514735] Proc Natl Acad Sci U S A. 1987 Apr;84(8):2449-53 [3470804] Hepatology. 1987 May-Jun;7(3):517-21 [3570162] Immunology. 1985 Oct;56(2):345-50 [4054945] J Immunol. 1985 Jun;134(6):3855-8 [3989300] Gastroenterology. 1985 Feb;88(2):436-43 [3965333] Adv Immunol. 1980;29:287-330 [6998260] J Immunol. 1978 Nov;121(5):1773-80 [309481] J Immunol. 1979 May;122(5):1892-8 [448111] Infect Immun. 1976 Jun;13(6):1692-8 [823107] J Immunol Methods. 1976;13(3-4):215-26 [796385] Ciba Found Symp. 1976;(42):129-47 [1086763] Eur J Immunol. 1974 Oct;4(10):701-4 [4214705] J Immunol Methods. 1988 May 25;110(1):85-91 [3373004] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Total skin electron beam radiation therapy for mycosis fungoides. AN - 72866889; 1553898 AB - Forty-nine patients with biopsy-proven mycosis fungoides, Stages I-IV were treated using total skin electron beam irradiation (TSEBI). Total dose ranged from 600 cGy to 3,200 cGy. To evaluate the dose response relationship, patients were retrospectively divided into two groups. In Group I, 18 patients received a dose of 2,000 cGy or less, and in Group II, 31 patients received more than 2,000 cGy. The overall response rate was 87.7% with a 75.7% complete response and 12.2% partial response. Complete response was higher among patients with early stage disease: (Stage IA 1/1, Stage IB 23/35 (92%), Stage IIA 3/4 (75%), Stage IIB 4/8 (50%), Stage III 3/6 (50%), Stage IVA 1/1, Stage IVB 0/1, and unstaged group 2/3 (66.6%)). Patients treated with a higher total dose had a higher overall 5-year survival rate (Group I 38%, Group II 68%), longer median duration of complete response (Group I, 27 months; Group II, 35.3 months), slightly better complete response rate (72.2% for Group I, 77.4% for Group II), and lower recurrence rate (Group I, 94%; Group II, 83.9%) compared to patients with lower total dose. Complications from TSEBI were minimal. Total skin electron beam irradiation is effective in controlling early stage mycosis fungoides; however, a prospective study to evaluate optimum total dose is needed. JF - American journal of clinical oncology AU - Reddy, S AU - Parker, C M AU - Shidnia, H AU - Gaffney, M G AU - Blyton, B D AU - Pruner, L M AU - Kalasinski, L A AD - Department of Radiation Oncology, Richard L. Roudebush Veterans Administration Medical Center/Indiana University Medical Center, Indianapolis 46202. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 119 EP - 124 VL - 15 IS - 2 SN - 0277-3732, 0277-3732 KW - Index Medicus KW - Neoplasm Staging KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Survival Analysis KW - Radiotherapy, High-Energy -- adverse effects KW - Mycosis Fungoides -- radiotherapy KW - Skin Neoplasms -- radiotherapy KW - Skin Neoplasms -- pathology KW - Radiotherapy, High-Energy -- methods KW - Mycosis Fungoides -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72866889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=Total+skin+electron+beam+radiation+therapy+for+mycosis+fungoides.&rft.au=Reddy%2C+S%3BParker%2C+C+M%3BShidnia%2C+H%3BGaffney%2C+M+G%3BBlyton%2C+B+D%3BPruner%2C+L+M%3BKalasinski%2C+L+A&rft.aulast=Reddy&rft.aufirst=S&rft.date=1992-04-01&rft.volume=15&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-29 N1 - Date created - 1992-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. AN - 72848893; 1548084 AB - Listeria monocytogenes strains previously generated by transposon mutagenesis were examined with respect to virulence and induction of protective immunity in BALB/c mice. The phenotypic defects observed in these mutant L. monocytogenes strains included decreased hemolysin (listeriolysin O [LLO]) production, phospholipase C activity, intracellular growth, and/or cell-to-cell spread in vitro. While 50% lethal dose determinations performed with these mutant strains indicated reduced virulence for BALB/c mice, sublethal infection with the majority of these mutant strains provided protection against a subsequent challenge with the fully virulent L. monocytogenes parent strain. In addition, in vitro infection of the J774 cell line with most of these mutant strains converted these phagocytic cells to targets of L. monocytogenes-immune cytotoxic cells. The exceptions to these findings were two LLO-negative, avirulent mutant strains which were unable to immunize mice against a secondary challenge with virulent L. monocytogenes. One of these mutants contained a transposon insertion within the structural gene for LLO, and the other contained a transposon insertion in the structural gene for the transcriptional activator of the LLO gene. These two LLO-negative mutant strains also were unable to escape phagolysosomes in infected J774 cells and could not transform these phagocytic cells into targets of L. monocytogenes-immune cytotoxic cells. These findings confirm the importance of LLO in the induction of antilisterial immunity and suggest that a cytoplasmic localization of these pathogenic bacteria is required for the development of protective immunity. JF - Infection and immunity AU - Barry, R A AU - Bouwer, H G AU - Portnoy, D A AU - Hinrichs, D J AD - Immunology Research, Veterans Administration Medical Center, Portland, Oregon 97207. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 1625 EP - 1632 VL - 60 IS - 4 SN - 0019-9567, 0019-9567 KW - Antibodies, Bacterial KW - 0 KW - Bacterial Toxins KW - Heat-Shock Proteins KW - Hemolysin Proteins KW - hlyA protein, Listeria monocytogenes KW - 72270-41-8 KW - Phospholipases KW - EC 3.1.- KW - Index Medicus KW - Animals KW - Listeriosis -- prevention & control KW - Antibodies, Bacterial -- immunology KW - Heat-Shock Proteins -- physiology KW - Mice KW - Mice, Inbred BALB C KW - Vaccination KW - Virulence KW - Lethal Dose 50 KW - Cytotoxicity Tests, Immunologic KW - Phagosomes -- physiology KW - Antibodies, Bacterial -- biosynthesis KW - Colony-Forming Units Assay KW - Phospholipases -- biosynthesis KW - Female KW - Cell Division KW - Listeria monocytogenes -- pathogenicity KW - Listeria monocytogenes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72848893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Pathogenicity+and+immunogenicity+of+Listeria+monocytogenes+small-plaque+mutants+defective+for+intracellular+growth+and+cell-to-cell+spread.&rft.au=Barry%2C+R+A%3BBouwer%2C+H+G%3BPortnoy%2C+D+A%3BHinrichs%2C+D+J&rft.aulast=Barry&rft.aufirst=R&rft.date=1992-04-01&rft.volume=60&rft.issue=4&rft.spage=1625&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-23 N1 - Date created - 1992-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1990 Apr;58(4):1048-58 [2108086] Infect Immun. 1990 Mar;58(3):654-8 [2106491] J Immunol. 1990 Dec 1;145(11):3540-6 [2147195] Clin Invest Med. 1984;7(4):303-9 [6442653] Rev Infect Dis. 1981 Nov-Dec;3(6):1221-50 [6805064] J Immunol. 1957 Apr;78(4):262-8 [13429097] J Exp Med. 1962 Sep 1;116:381-406 [14467923] J Cell Biol. 1989 Oct;109(4 Pt 1):1597-608 [2507553] Infect Immun. 1989 Nov;57(11):3629-36 [2509366] Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S650-9 [2961041] J Bacteriol. 1987 Mar;169(3):1291-7 [3029033] Infect Immun. 1986 May;52(2):401-7 [3084382] J Immunol. 1987 Apr 1;138(7):2266-71 [3104455] J Immunol. 1987 Aug 15;139(4):1104-7 [3112223] J Immunol. 1987 Sep 15;139(6):2005-9 [3114382] Infect Immun. 1987 Nov;55(11):2822-9 [3117693] Microb Pathog. 1986 Jun;1(3):249-60 [3150026] Immunology. 1985 Sep;56(1):33-42 [3876276] Infect Immun. 1985 Apr;48(1):263-6 [3920148] Infect Immun. 1974 Sep;10(3):489-98 [4214773] J Exp Med. 1969 May 1;129(5):993-1012 [4976111] Eur J Immunol. 1983 Mar;13(3):265-8 [6403361] Infect Immun. 1983 Mar;39(3):1208-13 [6404821] J Exp Med. 1979 Oct 1;150(4):1033-8 [117073] J Exp Med. 1991 Mar 1;173(3):751-4 [1847723] Nature. 1990 May 10;345(6271):175-6 [2110628] Proc Natl Acad Sci U S A. 1990 Nov;87(21):8336-40 [2122460] Infect Immun. 1990 Nov;58(11):3770-8 [2172168] J Exp Med. 1988 Apr 1;167(4):1459-71 [2833557] Infect Immun. 1986 Apr;52(1):50-5 [3007363] J Exp Med. 1986 Jul 1;164(1):363-8 [3088201] Infect Immun. 1987 Jul;55(7):1641-6 [3110067] Infect Immun. 1987 Sep;55(9):2300-3 [3114151] J Immunol. 1988 May 1;140(9):3173-9 [3129513] Immunology. 1987 Feb;60(2):287-93 [3493210] J Exp Med. 1973 Aug 1;138(2):342-55 [4198199] J Exp Med. 1972 May 1;135(5):1104-12 [4623315] Nature. 1982 May 20;297(5863):233-4 [6176874] Infect Immun. 1984 Oct;46(1):111-5 [6434424] Infect Immun. 1984 Jul;45(1):234-41 [6610639] J Exp Med. 1964 Jul 1;120:93-103 [14194395] Infect Immun. 1992 Apr;60(4):1263-7 [1312514] Mol Microbiol. 1991 Sep;5(9):2273-83 [1662763] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6068-72 [2117270] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychodynamic Group Treatment of Posttraumatic Stress Disorder in Vietnam Veterans AN - 61337830; 9306694 AB - Intrapsychic & interpersonal issues associated with combat exposure need to be addressed in treating Vietnam veterans suffering from posttraumatic stress disorder (PTSD). Group therapy is proposed as a core treatment for dealing with the loneliness, guilt, & helplessness of veterans with PTSD. A model is proposed in which patients are treated for 1+ year in weekly groups that meet for 16-week sequential segments. Clinical guidelines are made explicit to new members by the cotherapists. Discussion topics deal with traumatic experiences related to combat with important pre- & postwar issues relevant to the symptoms of PTSD. Timely integration & working through of these issues in the group is critical. 39 References. Adapted from the source document. JF - International Journal of Group Psychotherapy AU - Koller, Paul AU - Marmar, Charles R AU - Kanas, Nick AD - Post-Traumatic Stress Disorder Program Veterans Administration Medical Center, 4150 Clement St San Francisco CA 94121 Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 225 EP - 246 VL - 42 IS - 2 SN - 0020-7284, 0020-7284 KW - posttraumatic stress disorder, intrapsychic/interpersonal issues, Vietnam veterans' group therapy KW - Veterans KW - Vietnam War KW - Interpersonal Relations KW - Group Therapy KW - Posttraumatic Stress Disorder KW - Treatment Methods KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61337830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Group+Psychotherapy&rft.atitle=Psychodynamic+Group+Treatment+of+Posttraumatic+Stress+Disorder+in+Vietnam+Veterans&rft.au=Koller%2C+Paul%3BMarmar%2C+Charles+R%3BKanas%2C+Nick&rft.aulast=Koller&rft.aufirst=Paul&rft.date=1992-04-01&rft.volume=42&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Group+Psychotherapy&rft.issn=00207284&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJGPAO N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Treatment Methods; Interpersonal Relations; Veterans; Vietnam War; Group Therapy ER - TY - JOUR T1 - Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment. AN - 72863311; 1556130 AB - The relationship between maturation of lipoprotein lipase (LPL) and its translocation from the endoplasmic reticulum (ER) to the Golgi complex was determined by measuring lipolytic activity under conditions preventing transport of the enzyme from the ER to the Golgi compartment. In the presence of brefeldin A, a reagent that inhibits movement of proteins from the ER and causes the disassembly of the Golgi complex, pro-5 Chinese hamster ovary cells accumulated catalytically active LPL, while secretion of the enzyme was effectively blocked. LPL retained intracellularly by brefeldin A treatment possessed oligosaccharide chains that were processed to the complex form by the Golgi enzymes redistributed into the ER. At 16 degrees C, a condition disrupting protein transport to the cis-Golgi, the retained enzyme again remained catalytically active although the oligosaccharides remained in the high mannose form. Lastly, attachment of the specific ER retention signal KDEL (Lys-Asp-Glu-Leu) to the carboxyl terminus of LPL also resulted in intracellularly retained enzyme that was fully active. The importance of oligosaccharide processing for attainment of LPL catalytic activity in vitro was also determined. LPL was active and secreted when trimming of the mannose residues was inhibited by deoxymannojirimycin and when addition of complex sugars was blocked using Chinese hamster ovary mutants (lec1 and lec2), indicating that these processing events are not necessary for the expression of a functional enzyme. However, blocking glucose removal by glucosidase inhibitors (castanospermine and N-methyl-deoxynojirimycin) resulted in a significant reduction in LPL specific activity and secretion. Thus, glucose trimming of LPL oligosaccharides is essential for enzyme activation; however, further oligosaccharide processing or translocation of the enzyme to the cis-Golgi is not required for full expression of lipolytic activity in vitro. JF - The Journal of biological chemistry AU - Ben-Zeev, O AU - Doolittle, M H AU - Davis, R C AU - Elovson, J AU - Schotz, M C AD - Lipid Research, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1992/03/25/ PY - 1992 DA - 1992 Mar 25 SP - 6219 EP - 6227 VL - 267 IS - 9 SN - 0021-9258, 0021-9258 KW - Anti-Bacterial Agents KW - 0 KW - Cyclopentanes KW - Brefeldin A KW - 20350-15-6 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Animals KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Amino Acid Sequence KW - Glycosylation KW - Models, Biological KW - Mutagenesis KW - Cloning, Molecular KW - Base Sequence KW - Blotting, Western KW - Cyclopentanes -- pharmacology KW - Transfection KW - Kinetics KW - Genetic Vectors KW - Restriction Mapping KW - Molecular Sequence Data KW - CHO Cells KW - Cricetinae KW - Endoplasmic Reticulum -- enzymology KW - Lipoprotein Lipase -- biosynthesis KW - Golgi Apparatus -- enzymology KW - Lipoprotein Lipase -- metabolism KW - Lipoprotein Lipase -- genetics KW - Protein Processing, Post-Translational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72863311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Maturation+of+lipoprotein+lipase.+Expression+of+full+catalytic+activity+requires+glucose+trimming+but+not+translocation+to+the+cis-Golgi+compartment.&rft.au=Ben-Zeev%2C+O%3BDoolittle%2C+M+H%3BDavis%2C+R+C%3BElovson%2C+J%3BSchotz%2C+M+C&rft.aulast=Ben-Zeev&rft.aufirst=O&rft.date=1992-03-25&rft.volume=267&rft.issue=9&rft.spage=6219&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - [3Fe-4S] to [4Fe-4S] cluster conversion in Escherichia coli fumarate reductase by site-directed mutagenesis. AN - 72836570; 1312345 AB - Site-directed mutants of Escherichia coli fumarate reductase in which FrdB Cys204, Cys210, and Cys214 were individually replaced by Ser and in which Val207 was replaced by Cys were constructed and overexpressed in a strain of E. coli lacking a wild-type copy of fumarate reductase and succinate dehydrogenase. The consequences of these mutations on bacterial growth, enzymatic activity, and the EPR properties of the constituent iron-sulfur clusters were investigated. The FrdB Cys204Ser, Cys210Ser, and Cys214Ser mutations result in enzymes with negligible activity that have dissociated from the membrane and consequently are incapable of supporting cell growth under conditions requiring a functional fumarate reductase. EPR studies indicate that these effects are associated with loss of both the [3Fe-4S] and [4Fe-4S] clusters, centers 3 and 2, respectively. In contrast, the FrdB Val207Cys mutation results in a functional membrane-bound enzyme that is able to support growth under anaerobic and aerobic conditions. However, EPR studies indicate that the indigenous [3Fe-4S]+,0 cluster (Em = -70 mV), center 3, has been replaced by a much lower potential [4Fe-4S]2+,+ cluster (Em = -350 mV), indicating that the primary sequence of the polypeptide determines the type of clusters assembled. The results of these studies afford new insights into the role of centers 2 and 3 in mediating electron transfer from menaquinol, the residues that ligate these clusters, and the intercluster magnetic interactions in the wild-type enzyme. JF - Biochemistry AU - Manodori, A AU - Cecchini, G AU - Schröder, I AU - Gunsalus, R P AU - Werth, M T AU - Johnson, M K AD - Molecular Biology Division, Veterans Administration medical Center, San Francisco, California 94121. Y1 - 1992/03/17/ PY - 1992 DA - 1992 Mar 17 SP - 2703 EP - 2712 VL - 31 IS - 10 SN - 0006-2960, 0006-2960 KW - frdABCD KW - kan KW - sdhcDAB KW - Iron-Sulfur Proteins KW - 0 KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Index Medicus KW - Oxidation-Reduction KW - Sequence Homology, Nucleic Acid KW - Electron Spin Resonance Spectroscopy KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Plasmids KW - Mutation KW - Catalysis KW - Mutagenesis, Site-Directed KW - Succinate Dehydrogenase -- genetics KW - Iron-Sulfur Proteins -- genetics KW - Escherichia coli -- enzymology KW - Escherichia coli -- growth & development KW - Iron-Sulfur Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72836570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=%5B3Fe-4S%5D+to+%5B4Fe-4S%5D+cluster+conversion+in+Escherichia+coli+fumarate+reductase+by+site-directed+mutagenesis.&rft.au=Manodori%2C+A%3BCecchini%2C+G%3BSchr%C3%B6der%2C+I%3BGunsalus%2C+R+P%3BWerth%2C+M+T%3BJohnson%2C+M+K&rft.aulast=Manodori&rft.aufirst=A&rft.date=1992-03-17&rft.volume=31&rft.issue=10&rft.spage=2703&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-22 N1 - Date created - 1992-04-22 N1 - Date revised - 2017-01-13 N1 - Gene symbol - frdABCD; kan; sdhcDAB N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethanol and human saliva: effect of chronic alcoholism on flow rate, composition, and epidermal growth factor. AN - 85229652; pmid-1371639 AB - Parotid saliva samples from 24 alcoholic subjects without evidence of cirrhosis were analyzed for changes in flow rate, composition, and epidermal growth factor (EGF) secretion. Mean (+/- SE) stimulated parotid saliva flow rate (ml/min/gland) was significantly (p less than 0.01) lower in alcoholic subjects than in matched control subjects. Reduction in parotid saliva flow rate was associated with significant (p less than 0.05) decrease in total protein and amylase secretion in this group of patients. In addition, secretion of immunoreactive EGF, a specific salivary protein, was also markedly reduced (p less than 0.05) in alcoholic patients. None of the parotid saliva samples from the alcoholic subjects had detectable bioactivity of EGF in saliva. These data suggest that chronic alcohol ingestion is associated with significant changes in parotid saliva secretion and its composition, which may perpetuate and compound ethanol-induced injury to the upper gastrointestinal tract. JF - The American Journal of Gastroenterology AU - Dutta, S K AU - Orestes, M AU - Vengulekur, S AU - Kwo, P AD - Veterans Administration Medical Center, Baltimore, Maryland. PY - 1992 SP - 350 EP - 354 VL - 87 IS - 3 SN - 0002-9270, 0002-9270 KW - Electrolytes KW - Epidermal Growth Factor KW - Human KW - Adult KW - Alcoholism KW - Amylases KW - Middle Age KW - Saliva KW - Parotid Gland KW - Radioimmunoassay KW - Male KW - Salivary Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85229652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Ethanol+and+human+saliva%3A+effect+of+chronic+alcoholism+on+flow+rate%2C+composition%2C+and+epidermal+growth+factor.&rft.au=Dutta%2C+S+K%3BOrestes%2C+M%3BVengulekur%2C+S%3BKwo%2C+P&rft.aulast=Dutta&rft.aufirst=S&rft.date=1992-03-01&rft.volume=87&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of bovine serum albumin on the extent of ortho rearrangement of N-(sulfooxy)-2-fluorenylacetamide and of enzymatically activated N-hydroxy-2-fluorenylacetamide and on the binding of reactive esters to nucleic acids. AN - 73099930; 1643258 AB - We have investigated the effect of the bovine serum albumin (BSA)-catalyzed ortho rearrangement of synthetic and enzymatically generated N-(sulfooxy)-2-fluorenylacetamide (NSF) to the O-sulfate esters on the binding of NSF to transfer ribonucleic acid (tRNA) and to deoxyribonucleic acid (DNA). Binding of synthetic NSF to tRNA and DNA decreased approximately 90 and 70%, respectively, in the presence of BSA. Under these conditions, the ortho rearrangement, a minor reaction in the absence of BSA, was nearly quantitative. The decrease of adduct formation to nucleic acids was not attributable to the competitive binding of NSF to BSA. Binding of NSF, generated by cytosolic sulfonation of the arylhydroxamic acid, N-hydroxy-2-fluorenylacetamide, to tRNA, was diminished approximately 97% in the presence of BSA while the ortho rearrangement of the sulfonated substrate increased from less than 0.5% to approximately 50%. Adduct formation of DNA with N-hydroxy-2-fluorenylacetamide, activated by enzymatic sulfonation, was inhibited approximately 90% in the presence of BSA. In these experiments, the catalytic effect of BSA on the ortho rearrangement of enzymatically sulfonated N-hydroxy-2-fluorenylacetamide was of the same order as observed in the experiments with tRNA. The data obtained on the covalent interaction of DNA with enzymatically activated N-hydroxy-2-fluorenylacetamide indicate that, in addition to NSF, another electrophilic species accounts for binding of activated N-hydroxy-2-fluorenylacetamide to DNA. The data support the view that the reactive electrophile is N-acetoxy-2-fluorenamine, resulting from the N,O-transacetylation of N-hydroxy-2-fluorenylacetamide.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Kolanczyk, R C AU - Gutmann, H R AU - Rutks, I R AD - Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. PY - 1992 SP - 274 EP - 279 VL - 5 IS - 2 SN - 0893-228X, 0893-228X KW - Esters KW - 0 KW - Serum Albumin, Bovine KW - 2-acetylaminofluorene-N-sulfate KW - 16808-85-8 KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - DNA KW - 9007-49-2 KW - RNA, Transfer KW - 9014-25-9 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Esters -- chemistry KW - Cytosol -- metabolism KW - Animals KW - Liver -- metabolism KW - Male KW - Esters -- metabolism KW - RNA, Transfer -- metabolism KW - 2-Acetylaminofluorene -- metabolism KW - DNA -- metabolism KW - Serum Albumin, Bovine -- pharmacology KW - DNA -- chemistry KW - 2-Acetylaminofluorene -- analogs & derivatives KW - RNA, Transfer -- chemistry KW - 2-Acetylaminofluorene -- chemistry KW - Serum Albumin, Bovine -- chemistry KW - Hydroxyacetylaminofluorene -- metabolism KW - Hydroxyacetylaminofluorene -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73099930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Effect+of+bovine+serum+albumin+on+the+extent+of+ortho+rearrangement+of+N-%28sulfooxy%29-2-fluorenylacetamide+and+of+enzymatically+activated+N-hydroxy-2-fluorenylacetamide+and+on+the+binding+of+reactive+esters+to+nucleic+acids.&rft.au=Kolanczyk%2C+R+C%3BGutmann%2C+H+R%3BRutks%2C+I+R&rft.aulast=Kolanczyk&rft.aufirst=R&rft.date=1992-03-01&rft.volume=5&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Importance of the carboxyl terminus of human thyroid peroxidase in the efficient expression of the protein in eukaryotic cells. AN - 73087316; 1639219 AB - Carboxyl terminal truncation of membrane-associated human thyroid peroxidase (hTPO), with the elimination of its single membrane-spanning and short intracytoplasmic regions, generates a soluble, secreted, enzymatically active protein (amino acids 1-848). In order to determine the effects of further carboxyl terminal deletions on the expression of hTPO, Chinese hamster ovary cells were stably transfected with plasmids constructed to express amino acids 1-771, 1-636, 1-539 and 1-382 of the 933 amino acid TPO protein, respectively. Unlike hTPO1-848, the more severely truncated TPO mutant proteins could not be detected in conditioned media by polyclonal anti-TPO antibodies. Using detergent-solubilized microsomal proteins from these cells, very low levels of hTPO1-771 (approximately 90 kDa), but not the more extensive deletion mutations, were detected by these anti-TPO antibodies. Confirmation of the loss of efficient expression of more severely truncated hTPO was obtained using a anti-hTPO monoclonal antibody with an epitope near the amino terminus and which recognizes only the denatured protein. The mRNA for all hTPO mutants was detected in the stably-transfected Chinese hamster ovary cells. In summary, the present study indicates that a largely intact extracellular portion of hTPO is required for expression in eukaryotic cells. JF - Molecular and cellular endocrinology AU - Finke, R AU - Foti, D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans' Administration Medical Center, San Francisco, CA 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 73 EP - 78 VL - 84 IS - 1-2 SN - 0303-7207, 0303-7207 KW - RNA, Messenger KW - 0 KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Animals KW - Blotting, Western KW - Base Sequence KW - Transfection KW - Humans KW - RNA, Messenger -- analysis KW - Molecular Sequence Data KW - Precipitin Tests KW - Plasmids KW - Female KW - Cricetinae KW - Iodide Peroxidase -- biosynthesis KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73087316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Importance+of+the+carboxyl+terminus+of+human+thyroid+peroxidase+in+the+efficient+expression+of+the+protein+in+eukaryotic+cells.&rft.au=Finke%2C+R%3BFoti%2C+D%3BRapoport%2C+B&rft.aulast=Finke&rft.aufirst=R&rft.date=1992-03-01&rft.volume=84&rft.issue=1-2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-28 N1 - Date created - 1992-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies on the role of amino acids 38-45 in the expression of a functional thyrotropin receptor. AN - 72957256; 1584215 AB - We previously reported that deletion or substitution of a unique eight-amino acid tract (residues 38-45) in the extracellular domain of the human TSH receptor led to the loss of specific ligand binding to the surface of transfected cells. In the present study we analyzed this region in more detail. Using site-directed mutagenesis of the TSH receptor cDNA, we substituted amino acid residues 38-45, either in three overlapping groups of four amino acids each or individually. The resultant TSH receptor mutant cDNAs were stably transfected into Chinese hamster ovary cells, and the cells were tested for their TSH-binding ability. Our data demonstrate that amino acid residues 38-40 and 42-45 in this region of the human TSH receptor can be substituted without alteration in receptor function and are, therefore, not critical in forming or maintaining the TSH-binding site. However, substitution of Cys41, either alone or together with adjacent amino acids, leads to the loss of TSH binding to its receptor. These data suggest a central role for the amino acid in position 41 in preserving the biological function of the TSH receptor. JF - Molecular endocrinology (Baltimore, Md.) AU - Wadsworth, H L AU - Russo, D AU - Nagayama, Y AU - Chazenbalk, G D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 394 EP - 398 VL - 6 IS - 3 SN - 0888-8809, 0888-8809 KW - Receptors, Thyrotropin KW - 0 KW - Index Medicus KW - Animals KW - Base Sequence KW - Mutagenesis, Site-Directed -- genetics KW - Transfection -- genetics KW - Molecular Sequence Data KW - CHO Cells KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Cricetinae KW - Receptors, Thyrotropin -- chemistry KW - Gene Expression -- genetics KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72957256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Studies+on+the+role+of+amino+acids+38-45+in+the+expression+of+a+functional+thyrotropin+receptor.&rft.au=Wadsworth%2C+H+L%3BRusso%2C+D%3BNagayama%2C+Y%3BChazenbalk%2C+G+D%3BRapoport%2C+B&rft.aulast=Wadsworth&rft.aufirst=H&rft.date=1992-03-01&rft.volume=6&rft.issue=3&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-18 N1 - Date created - 1992-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats. AN - 72942517; 1583909 AB - Elderly patients with alcoholism often require surgery and receive nitrous oxide (N2O) as a component of their anesthetic. Since aging, ethanol, and N2O may all perturb folate and/or vitamin B12 metabolism, we examined the combined influence of these parameters on vitamin B12/folate status in a rodent model. Aged male Fischer 344 rats (24 months old) were given a liquid ethanol diet (35% of calories as ethanol) and control rats were pair-fed a liquid diet with carbohydrate substituting for the caloric content of ethanol. After receiving liquid diets for 7 weeks, rats were exposed to 60% N2O/40% 0(2) for 6 h. Urinary excretion of formic acid, formiminoglutamic acid (FIGLU), and methylmalonic acid (MMA) were used as indirect markers of folate/vitamin B12 status. In both the aged ethanol-fed and control groups, excretion of formic acid and FIGLU markedly increased the first day after N2O exposure and returned towards background values by the second day. No changes occurred in MMA excretion. Exposure to N2O decreased methionine synthase activities in liver, kidney and brain, and recovery of methionine synthase activities occurred over a period of 4 days in both the aged ethanol-fed and control groups. Ethanol treatment for 7 weeks combined with acute exposure to N2O did not deplete the aged rats of folate or vitamin B12 in blood, liver, kidney or brain. Thus, in this animal model, aging, chronic ethanol administration, and acute N2O exposure did not act synergistically to produce prolonged and severe disturbances in folate and vitamin B12 metabolism. JF - Mechanisms of ageing and development AU - Everman, B W AU - Koblin, D D AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1992/03/01/ PY - 1992 DA - 1992 Mar 01 SP - 229 EP - 243 VL - 62 IS - 3 SN - 0047-6374, 0047-6374 KW - Folic Acid KW - 935E97BOY8 KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase KW - EC 2.1.1.13 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Nitrous Oxide -- toxicity KW - Disease Models, Animal KW - Alcoholism -- metabolism KW - Male KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- metabolism KW - Aging -- metabolism KW - Folic Acid -- metabolism KW - Vitamin B 12 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72942517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Aging%2C+chronic+administration+of+ethanol%2C+and+acute+exposure+to+nitrous+oxide%3A+effects+on+vitamin+B12+and+folate+status+in+rats.&rft.au=Everman%2C+B+W%3BKoblin%2C+D+D&rft.aulast=Everman&rft.aufirst=B&rft.date=1992-03-01&rft.volume=62&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dangerous consequences: neuroleptic-induced tardive akathisia. AN - 72930729; 1349651 JF - Journal of psychosocial nursing and mental health services AU - Blair, D T AU - Dauner, A AD - Colmery-O'Neil Veterans Administration Medical Center, Topeka, Kansas. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 41 EP - 43 VL - 30 IS - 3 SN - 0279-3695, 0279-3695 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Incidence KW - Dyskinesia, Drug-Induced -- therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72930729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=Dangerous+consequences%3A+neuroleptic-induced+tardive+akathisia.&rft.au=Blair%2C+D+T%3BDauner%2C+A&rft.aulast=Blair&rft.aufirst=D&rft.date=1992-03-01&rft.volume=30&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-10 N1 - Date created - 1992-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking. A comparison of schizophrenics with normals and substance abusing controls. AN - 72916230; 1349241 AB - The eye movements of schizophrenic patients are characterized by decreased smooth pursuit gain and an increased frequency of saccades. However, the nature of these saccades and their function during smooth pursuit has not been clearly defined. To address this issue we examined the eye movements of 22 schizophrenic patients, 20 substance abusing patients (primarily alcohol; some with concomitant cocaine and/or cannabis abuse), and 17 normal controls during a visual pursuit task using infra-red oculography. A computerized pattern recognition algorithm divided pursuit eye movements into two basic components: smooth pursuit and saccadic eye movements. The algorithm also determined eye position error and velocity error before and after each saccade. Schizophrenic patients had lower smooth pursuit gain (p less than 0.02) and made more saccades during smooth pursuit (p less than 0.02) than either comparison group. When saccades were assigned to subcategories based on direction and position error, only the frequency of 'catch-up' saccades differentiated schizophrenic patients from the comparison groups (p less than 0.05). Smooth pursuit gain was negatively correlated with saccadic frequency among all three subject groups. Eye velocity preceding saccades was significantly lower among the schizophrenic patients, but pre or post saccadic position error did not differ among the three groups. Discrete analysis of the fine structure of visual pursuit tracking may lead to a better understanding of eye movement abnormalities in schizophrenia. JF - Schizophrenia research AU - Radant, A D AU - Hommer, D W AD - Veterans Administration Medical Center, Department of Psychiatry, Seattle, WA 98108. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 225 EP - 235 VL - 6 IS - 3 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Adult KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Alcoholism -- diagnosis KW - Schizophrenia -- diagnosis KW - Schizophrenic Psychology KW - Schizophrenia -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Pursuit, Smooth -- drug effects KW - Alcoholism -- psychology KW - Saccades -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72916230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=A+quantitative+analysis+of+saccades+and+smooth+pursuit+during+visual+pursuit+tracking.+A+comparison+of+schizophrenics+with+normals+and+substance+abusing+controls.&rft.au=Radant%2C+A+D%3BHommer%2C+D+W&rft.aulast=Radant&rft.aufirst=A&rft.date=1992-03-01&rft.volume=6&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-04 N1 - Date created - 1992-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of noise bandwidth on the late-potential masking level difference. AN - 72848798; 1372230 AB - The masking level difference (MLD) is a psychoacoustic phenomenon derived from the subtraction of S pi No thresholds (signals pi radians out of phase and noise in phase at the two ears) from SoNo thresholds (signals and noise in phase at the two ears). The purpose of this study was to determine if the MLD derived from the late components (P1, N1, P2, N2) of the auditory evoked potentials was a physiological correlate of the behavioral MLD. Subjects were 15 young adults with normal hearing. Comparisons were made between behavioral and late potential thresholds to 500 Hz stimuli in So and S pi conditions in quiet, and to 500 Hz stimuli in SoNo and S pi No conditions in narrow band (50 Hz) and wide band (600 Hz) noise. No significant differences were seen for behavioral or late-potential thresholds to So and S pi conditions. The S pi No thresholds was significantly lower than the SoNo threshold, yielding an MLD for both the behavioral and physiological responses. The magnitudes of both the behavioral and late-potential MLD were larger with the narrow band noise than with the wide band noise. Evidence, therefore, is provided that the late-potential MLD reflects similar processes as are responsible for the behavioral MLD. JF - Electroencephalography and clinical neurophysiology AU - Fowler, C G AU - Mikami, C M AD - Veterans Administration Medical Center, Long Beach, CA 90822. PY - 1992 SP - 157 EP - 163 VL - 84 IS - 2 SN - 0013-4694, 0013-4694 KW - Index Medicus KW - Auditory Threshold -- physiology KW - Analysis of Variance KW - Humans KW - Electroencephalography KW - Adult KW - Acoustic Stimulation KW - Behavior -- physiology KW - Time Factors KW - Perceptual Masking -- physiology KW - Noise KW - Evoked Potentials, Auditory -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72848798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electroencephalography+and+clinical+neurophysiology&rft.atitle=Effects+of+noise+bandwidth+on+the+late-potential+masking+level+difference.&rft.au=Fowler%2C+C+G%3BMikami%2C+C+M&rft.aulast=Fowler&rft.aufirst=C&rft.date=1992-03-01&rft.volume=84&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Electroencephalography+and+clinical+neurophysiology&rft.issn=00134694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-21 N1 - Date created - 1992-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lamellar body secretory response to barrier disruption. AN - 72841060; 1545137 AB - Abundant evidence points to an important role for epidermal lamellar body secretion in permeability-barrier maintenance. However, the response of the lamellar body secretory system to barrier disruption has not been examined. Hence, we examined the lamellar body secretory response at various points after acetone-induced barrier abrogation in hairless mice in air-exposed animals and those occluded with impermeable versus vapor-permeable membranes. Tape-stripped animals served as a control for chemical toxicity. Barrier perturbation with either acetone or tape stripping was followed by rapid secretion of lamellar body contents from the uppermost granular cell layer, leaving the cytosol largely devoid of lamellar bodies. The newly secreted lamellar body contents comprised pleated sheets (not "discs," as previously thought), which unfurled in the intercellular spaces at the granular-cornified cell interface. At this time (15-30 min), the basic unit structure of the lamellar bilayers in the mid-to-upper stratum corneum appeared disorganized and interspersed with large lacunae, reflecting solvent extraction. Nascent lamellar bodies began to reappear in the granular cell cytosol by 30 min and by 360 min the cells displayed a full complement of normal-appearing lamellar bodies. Between 60 and 360 min, the density of lamellar body sheets at the granular-cornified cell interface increased, whereas the membrane bilayers of the outer stratum corneum remained disorganized. New lamellar bilayer units first appeared in the lower stratum corneum between 60 and 180 min, as a result of the transformation of secreted lamellar body sheets and over time these lamellae appeared at more apical locations. Occlusion with a water vapor-impermeable but not a vapor-permeable membrane resulted in a) decreased quantities of lamellar bodies and lamellar body-derived intercellular products; b) formation of lamellar bodies with abnormal internal contents; c) inhibition of lamellar body secretion; and d) inhibition of transformation of lamellar body-derived sheets into lamellar bilayer units. These results demonstrate the central role of the lamellar body-secretory system in barrier repair and homeostasis. JF - The Journal of investigative dermatology AU - Menon, G K AU - Feingold, K R AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 279 EP - 289 VL - 98 IS - 3 SN - 0022-202X, 0022-202X KW - Acetone KW - 1364PS73AF KW - Index Medicus KW - Permeability KW - Animals KW - Acetone -- pharmacology KW - Mice KW - Mice, Hairless KW - Epidermis -- secretion KW - Epidermis -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72841060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Lamellar+body+secretory+response+to+barrier+disruption.&rft.au=Menon%2C+G+K%3BFeingold%2C+K+R%3BElias%2C+P+M&rft.aulast=Menon&rft.aufirst=G&rft.date=1992-03-01&rft.volume=98&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-15 N1 - Date created - 1992-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A preliminary trial of beta-carotene in subjects infected with the human immunodeficiency virus. AN - 72837474; 1347316 AB - beta-Carotene is a nontoxic carotenoid with immunomodulating properties in animals and humans. Based on our observations in normal immunocompetent subjects, we studied the effects of this compound in 11 patients infected with the human immunodeficiency virus (HIV). Each subject received 60 mg of beta-carotene daily for 4 mo. Clinical and laboratory studies were obtained at baseline, every month while on treatment and for 2 mo after treatment. Increases in the percent of cells expressing Leu 11 (natural killer cells), Ia antigen and transferrin receptor (activated lymphocytes) were observed after 3 mo of treatment with beta-carotene and diminished thereafter. Major changes were not seen in total lymphocyte count or in the percent of cells expressing CD11, CD8 or CD4 antigens. No clinical toxicity was observed. These data suggest that beta-carotene can modulate certain immune markers in HIV-infected subjects. Further study of this compound in HIV infection may be warranted. JF - The Journal of nutrition AU - Garewal, H S AU - Ampel, N M AU - Watson, R R AU - Prabhala, R H AU - Dols, C L AD - Department of Internal Medicine, Tucson Veterans Administration Medical Center, AZ 85723. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 728 EP - 732 VL - 122 IS - 3 Suppl SN - 0022-3166, 0022-3166 KW - beta Carotene KW - 01YAE03M7J KW - Carotenoids KW - 36-88-4 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Skin Tests KW - CD4-Positive T-Lymphocytes -- pathology KW - CD4-Positive T-Lymphocytes -- immunology KW - Leukocyte Count KW - Lymphocyte Activation KW - Lymphocytes -- pathology KW - Drug Evaluation KW - Lymphocytes -- immunology KW - Adult KW - Middle Aged KW - Male KW - Carotenoids -- therapeutic use KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72837474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=A+preliminary+trial+of+beta-carotene+in+subjects+infected+with+the+human+immunodeficiency+virus.&rft.au=Garewal%2C+H+S%3BAmpel%2C+N+M%3BWatson%2C+R+R%3BPrabhala%2C+R+H%3BDols%2C+C+L&rft.aulast=Garewal&rft.aufirst=H&rft.date=1992-03-01&rft.volume=122&rft.issue=3+Suppl&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-06 N1 - Date created - 1992-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intragastric nicotine protects against 40% ethanol-induced gastric mucosal injury despite pretreatment with propranolol or N-ethylmaleimide in rats. AN - 72789922; 1735363 AB - We tested the hypotheses that the protective effect of intragastric nicotine against ethanol-induced gastric mucosal injury is dependent on propranolol- or N-ethylmaleimide-sensitive mechanisms. Propranolol was administered in doses (2 and 20 mg/kg) that provided dose-related blockade of beta-adrenoceptors (significant decreases in heart rate). N-Ethylmaleimide was administered in doses that previously had been shown to increase gastric vascular permeability (10 mg/kg) or inhibit gastric mucosal sulfhydryl compounds (50 mg/kg). At 0.5 hr after these or control subcutaneous pretreatments, the rats received intragastric nicotine (4 mg/kg) or vehicle. One hour later 40% ethanol was given intragastrically. The gastric corpus mucosal lesions were recorded by polaroid photographs after another hour, and their areas measured unbiasedly by computerized image analysis. The results showed that N-ethylmaleimide, but not propranolol, aggravated ethanol-induced gastric mucosal injury. The protective effect of intragastric nicotine was not modified by either pretreatment. We conclude that the mechanism mediating intragastric nicotine protection against 40% ethanol-induced gastric mucosal injury is independent of propranolol- or N-ethylmaleimide-sensitive mechanisms. JF - Digestive diseases and sciences AU - Endoh, K AU - Ro, G AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, Center for Ulcer Research and Education, UCLA School of Medicine 91343. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 391 EP - 396 VL - 37 IS - 3 SN - 0163-2116, 0163-2116 KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Propranolol KW - 9Y8NXQ24VQ KW - Ethylmaleimide KW - O3C74ACM9V KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Male KW - Stomach Diseases -- chemically induced KW - Propranolol -- pharmacology KW - Nicotine -- pharmacology KW - Premedication KW - Gastric Mucosa -- drug effects KW - Stomach Diseases -- prevention & control KW - Ethylmaleimide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+nicotine+protects+against+40%25+ethanol-induced+gastric+mucosal+injury+despite+pretreatment+with+propranolol+or+N-ethylmaleimide+in+rats.&rft.au=Endoh%2C+K%3BRo%2C+G%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1992-03-01&rft.volume=37&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potentiation of IL-2-induced t-cell proliferation by retinoids. AN - 73049347; 1624219 AB - We evaluated the capacity of retinoids to potentiate proliferative responses of murine T-cells to recombinant human interleukin 2 (rIL-2). Concanavalin A (Con A) prestimulated spleen cells responded in a dose-dependent manner to added rIL-2. All-trans-retinoic acid (RA) at 10(-8) M potentiated the proliferative response by fivefold at saturating levels of IL-2. In similar experiments, two closely related retinamides, all-trans-(phenyl)retinamide (PR) and N-(4-hydroxyphenyl)retinamide (4-HPR), also potentiated murine splenocyte rIL-2 responses. Potentiation of IL-2-induced proliferation was dose-responsive to the concentration of added retinoid with peak potentiation occurring at 10(-10) - 10(-8) M in the presence of 10 U/ml rIL-2. Significant potentiation was observed at retinoid concentrations as low as 10(-14) M. Fluorescence flow cytometry of the responding cells revealed that among L3T4+, Lyt-2+ or total T-cells, at 72 h following Con A stimulation, essentially all of the cells expressed IL-2 receptors (IL-2R). This apparently represents near maximum IL-2R expression and treatment of the cells with retinoids did not increase IL-2R expression at that time point. The potentiation of IL-2 responses by retinoids was also observed with IL-2-dependent HT-2 cells, 98% of which were IL-2R positive. HT-2 proliferative responses to rIL-2 were potentiated as much as fourfold by 10(-10) M RA. HT-2 proliferative responses to rIL-2 were potentiated by all three retinoids dose dependently. Significant potentiation was observed with as little as 10(-14) M retinoid. Retinoids in the absence of IL-2 induced no proliferative responses. These data suggest that retinoids can augment the capacity of IL-2 to induce T-cell proliferation using Con A-activated murine splenic T-cell blasts and a long-term-cultured T-cell line. JF - International journal of immunopharmacology AU - Jiang, X L AU - Dillehay, D L AU - Everson, M P AU - Tilden, A B AU - Lamon, E W AD - Birmingham Veterans Administration Medical Center, AL. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 195 EP - 204 VL - 14 IS - 2 SN - 0192-0561, 0192-0561 KW - Interleukin-2 KW - 0 KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Interleukin-4 KW - 207137-56-2 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Receptors, Interleukin-2 -- analysis KW - Cells, Cultured KW - Interleukin-4 -- pharmacology KW - Mice KW - Mice, Inbred BALB C KW - Drug Synergism KW - Female KW - Lymphocyte Activation -- drug effects KW - Tretinoin -- pharmacology KW - Interleukin-2 -- pharmacology KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73049347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Potentiation+of+IL-2-induced+t-cell+proliferation+by+retinoids.&rft.au=Jiang%2C+X+L%3BDillehay%2C+D+L%3BEverson%2C+M+P%3BTilden%2C+A+B%3BLamon%2C+E+W&rft.aulast=Jiang&rft.aufirst=X&rft.date=1992-02-01&rft.volume=14&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-13 N1 - Date created - 1992-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma-bearing mice. AN - 72921350; 1579055 AB - To test for a regulatory defect in adipose triacylglycerol (essential) fatty acid mobilization in lymphoma-bearing mice, free [1-14C]linoleic acid/mouse serum albumin was injected iv into lymphoma-bearing and control mice, adapted to a reversed light cycle, and studied in three dietary states in the dark period. Mean daily food intake decreased in mice with small and large tumor burdens. Plasma free fatty acid (FFA) oxidation rates, which approximate FFA mobilization rates, were estimated by multicompartmental analysis (CONSAM). Oxidation of linoleate to CO2 was reduced significantly (85%) in ad libitum fed as compared to briefly fasted control mice but not in fed vs. fasted mice with large or small tumor burdens. However, plasma FFA oxidation rates to CO2 did not differ in briefly fasted tumor-bearing and pair-fed control mice. When re-fed a 250-mg test meal, briefly fasted mice with small tumors suppressed plasma free linoleic acid oxidation, as did controls. During simulated night, mildly anorexic, tumor-bearing mice with small tumor burdens mobilized essential fatty acids much faster than controls. This could explain body fat loss. The abnormally rapid rates of FFA (free linoleic acid) mobilization at night probably result from anorexia rather than from inability of food to suppress fat mobilization. JF - Lipids AU - Kannan, R AU - Gan-Elepano, M AU - Baker, N AD - Liver Research Laboratory, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 117 EP - 123 VL - 27 IS - 2 SN - 0024-4201, 0024-4201 KW - Appetite Depressants KW - 0 KW - Fatty Acids KW - Linoleic Acids KW - Peptides KW - lipid mobilizing substance KW - Linoleic Acid KW - 9KJL21T0QJ KW - Index Medicus KW - Animals KW - Fasting -- adverse effects KW - Body Burden KW - Appetite Regulation -- physiology KW - Metabolic Clearance Rate KW - Disease Models, Animal KW - Neoplasms, Experimental -- metabolism KW - Mice KW - Peptides -- physiology KW - Male KW - Lipid Mobilization -- physiology KW - Linoleic Acids -- metabolism KW - Lymphoma -- metabolism KW - Fatty Acids -- metabolism KW - Anorexia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72921350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Anorexic+contribution+to+increased+linoleate+mobilization+and+oxidation+in+lymphoma-bearing+mice.&rft.au=Kannan%2C+R%3BGan-Elepano%2C+M%3BBaker%2C+N&rft.aulast=Kannan&rft.aufirst=R&rft.date=1992-02-01&rft.volume=27&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-11 N1 - Date created - 1992-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outcomes of co-morbid alcoholic men: a 1-year follow-up. AN - 72879175; 1313661 AB - In this prospective, 1-year study, 360 males admitted to an inpatient alcoholism treatment program were administered a DSM-III compatible structured interview and subtyped by co-occurring psychiatric disorder. Forty percent satisfied diagnostic criteria for alcohol dependence while 27% met criteria for alcohol dependence and one additional psychiatric syndrome. The dually diagnosed patients were divided into: alcohol dependence plus drug abuse, alcohol dependence plus antisocial personality and alcohol dependence plus depression. These subtypes were compared on multiple dimensions at intake and at 1-year follow-up. At follow-up, all groups showed significant improvement in drinking and psychosocial functioning. The results suggest that subtyping alcoholics by co-morbid psychiatric disorders may be a good postdictor of clinical history, but a poor predictor of drinking outcome. JF - Alcoholism, clinical and experimental research AU - Powell, B J AU - Penick, E C AU - Nickel, E J AU - Liskow, B I AU - Riesenmy, K D AU - Campion, S L AU - Brown, E F AD - Veterans Administration Medical Center, Kansas City, Missouri 64128-2295. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 131 EP - 138 VL - 16 IS - 1 SN - 0145-6008, 0145-6008 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Depressive Disorder -- psychology KW - Humans KW - Antisocial Personality Disorder -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Substance Abuse Treatment Centers KW - Adult KW - Antisocial Personality Disorder -- rehabilitation KW - Follow-Up Studies KW - Middle Aged KW - Male KW - Depressive Disorder -- rehabilitation KW - Alcoholism -- rehabilitation KW - Mental Disorders -- rehabilitation KW - Mental Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72879175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Outcomes+of+co-morbid+alcoholic+men%3A+a+1-year+follow-up.&rft.au=Powell%2C+B+J%3BPenick%2C+E+C%3BNickel%2C+E+J%3BLiskow%2C+B+I%3BRiesenmy%2C+K+D%3BCampion%2C+S+L%3BBrown%2C+E+F&rft.aulast=Powell&rft.aufirst=B&rft.date=1992-02-01&rft.volume=16&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of cAMP in mediating effects of fasting on dephosphorylation of insulin receptor. AN - 72821426; 1311506 AB - We studied the effect of fasting on phosphotyrosine phosphatase (PTPase) activities in particulate (PF) and cytosolic (CF) fractions of rat adipocytes and liver. PTPase activity was assessed using [32P]tyrosine insulin receptor (IR). In adipocytes, 48 h fasting significantly inhibited PTPase activity. Dephosphorylation of IR by PF and CF PTPases was reduced by 80 and 65%, respectively. Similar reductions of lesser magnitude were observed in fasted rat livers. The effect of fasting was completely reversed by either refeeding or by incubating "fasted" adipocytes for 2 h in tissue culture medium containing 5 mM glucose. Neither 20 mM glucose nor the presence of insulin influenced phosphatase activity. Because fasting is accompanied by elevated protein kinase C (PKC) and adenosine 3',5'-cyclic monophosphate (cAMP) levels, we examined their influence on adipocyte PTPases. Neither activation (1 microM 12-O-tetradecanoylphorbol-13-acetate) nor inhibition (20 microM sphingosine) of PKC affected PTPase activity. In contrast, cAMP (2 mM) significantly inhibited PTPase activity (80% inhibition at 2 h), and its effect was prevented by a cAMP antagonist RpcAMP. Fasting- and cAMP-induced inhibition of PTPase activity was restored by incubating PF with trypsin (4 micrograms/ml for 5 min), which separated the putative inhibitors from the phosphatases. We conclude that fasting-induced inhibition of PTPases is mediated by elevated cAMP levels, most likely by activating phosphatase inhibitors. JF - The American journal of physiology AU - Begum, N AU - Graham, A L AU - Sussman, K E AU - Draznin, B AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - E142 EP - E149 VL - 262 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Bucladesine KW - 63X7MBT2LQ KW - Cyclic AMP KW - E0399OZS9N KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Protein Tyrosine Phosphatases KW - EC 3.1.3.48 KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Protein Tyrosine Phosphatases -- metabolism KW - Phosphorylation KW - Glucose -- pharmacology KW - Adipose Tissue -- cytology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Bucladesine -- pharmacology KW - Adipose Tissue -- enzymology KW - Protein Tyrosine Phosphatases -- antagonists & inhibitors KW - Male KW - Fasting KW - Cyclic AMP -- physiology KW - Receptor, Insulin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72821426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+cAMP+in+mediating+effects+of+fasting+on+dephosphorylation+of+insulin+receptor.&rft.au=Begum%2C+N%3BGraham%2C+A+L%3BSussman%2C+K+E%3BDraznin%2C+B&rft.aulast=Begum&rft.aufirst=N&rft.date=1992-02-01&rft.volume=262&rft.issue=2+Pt+1&rft.spage=E142&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Case report: distinctive immune abnormalities in a patient with procainamide-induced lupus and serositis. AN - 72819835; 1371640 AB - To gain insight into the immunopathogenesis of drug-induced autoimmune disorders, lymphocyte and immunoglobulin distributions and cytokine levels were monitored in the peripheral blood and pleural fluid of a patient with procainamide-induced lupus and pleural effusion. Approximately 80% of the B cells in both compartments were CD5+ compared to 10% to 25% in normal adults. CD4/CD8 ratio and percentage CD4 were normal in peripheral blood. Serum levels of IgG (particularly IgG2), IL-6, and soluble IL-2R were slightly elevated, and those of IgA were significantly elevated compared to normal controls. Analysis of the pleural effusion revealed an increased CD4/CD8 ratio because of an increased percentage of CD4+CD29+ helper memory T cells, lack of expression of the resting B-cell marker CD21, immune complex deposition and complement consumption, increased relative levels of ANA, abnormally high levels of IL-6 and soluble IL-2R, and detectable levels of IL-1b, IFN-g and TNF-a. These observations provide evidence for the involvement of CD5+ B cells and differential helper T-cell activity in procainamide-induced lupus and for an association between local lymphocyte activation and organ pathology. JF - The American journal of the medical sciences AU - Klimas, N G AU - Patarca, R AU - Perez, G AU - Garcia-Morales, R AU - Schultz, D AU - Schabel, J AU - Fletcher, M A AD - Miami Veterans Administration Medical Center, Florida. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 99 EP - 104 VL - 303 IS - 2 SN - 0002-9629, 0002-9629 KW - Antigens, CD KW - 0 KW - Antigens, CD29 KW - Antigens, CD4 KW - Antigens, CD5 KW - Cytokines KW - Receptors, Interleukin-2 KW - Procainamide KW - L39WTC366D KW - Abridged Index Medicus KW - Index Medicus KW - Antigens, CD -- analysis KW - Antigens, CD4 -- analysis KW - Receptors, Interleukin-2 -- analysis KW - Humans KW - Autoimmune Diseases -- chemically induced KW - Aged KW - B-Lymphocytes -- immunology KW - Male KW - Autoimmune Diseases -- immunology KW - Cytokines -- analysis KW - Lymphocytes -- immunology KW - Lupus Vulgaris -- chemically induced KW - Procainamide -- adverse effects KW - Serositis -- chemically induced KW - Serositis -- immunology KW - Lupus Vulgaris -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72819835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Case+report%3A+distinctive+immune+abnormalities+in+a+patient+with+procainamide-induced+lupus+and+serositis.&rft.au=Klimas%2C+N+G%3BPatarca%2C+R%3BPerez%2C+G%3BGarcia-Morales%2C+R%3BSchultz%2C+D%3BSchabel%2C+J%3BFletcher%2C+M+A&rft.aulast=Klimas&rft.aufirst=N&rft.date=1992-02-01&rft.volume=303&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-27 N1 - Date created - 1992-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transesophageal echocardiographic diagnosis of acute aortic dissection complicating cocaine abuse. AN - 72806919; 1736595 JF - American heart journal AU - Om, A AU - Porter, T AU - Mohanty, P K AD - McGuire Veterans Administration Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 532 EP - 534 VL - 123 IS - 2 SN - 0002-8703, 0002-8703 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Aneurysm, Dissecting -- diagnostic imaging KW - Echocardiography -- methods KW - Aneurysm, Dissecting -- chemically induced KW - Aortic Aneurysm -- chemically induced KW - Substance Abuse, Intravenous -- complications KW - Aortic Aneurysm -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72806919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Transesophageal+echocardiographic+diagnosis+of+acute+aortic+dissection+complicating+cocaine+abuse.&rft.au=Om%2C+A%3BPorter%2C+T%3BMohanty%2C+P+K&rft.aulast=Om&rft.aufirst=A&rft.date=1992-02-01&rft.volume=123&rft.issue=2&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-06 N1 - Date created - 1992-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The late auditory evoked potential masking-level difference as a function of noise level. AN - 72801287; 1735971 AB - The purpose of this study was to determine whether the masking-level difference (MLD) obtained with the late (P2) auditory evoked potentials has characteristics similar to those reported for the behavioral MLD with respect to the effects of noise level. Psychoacoustic studies have shown that the magnitude of the MLD increases as a function of the noise level. In the present study, P2 thresholds were measured in SoNo (signals and noise in phase at the ears) and S pi No (signals out of phase and noise in phase at the ears) conditions for noise levels of 0-60 dB pressure spectrum level (Lps). Subjects were 5 normal-hearing young adults. The difference in SoNo and S pi No thresholds, or the MLD, increased linearly as the noise levels increased through 60 dB Lps, whereas the behavioral MLD magnitude is reported to saturate at high noise levels. These results suggest that the late-potential MLD reflects characteristics similar to, but not identical with, those of the behavioral MLD. JF - Journal of speech and hearing research AU - Fowler, C G AU - Mikami, C M AD - Veterans Administration Medical Center, Long Beach, CA. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 216 EP - 221 VL - 35 IS - 1 SN - 0022-4685, 0022-4685 KW - Index Medicus KW - Auditory Threshold KW - Humans KW - Adult KW - Male KW - Female KW - Noise KW - Evoked Potentials, Auditory KW - Perceptual Masking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72801287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech+and+hearing+research&rft.atitle=The+late+auditory+evoked+potential+masking-level+difference+as+a+function+of+noise+level.&rft.au=Fowler%2C+C+G%3BMikami%2C+C+M&rft.aulast=Fowler&rft.aufirst=C&rft.date=1992-02-01&rft.volume=35&rft.issue=1&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech+and+hearing+research&rft.issn=00224685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aspiration injury due to polyacrylamide. AN - 72800773; 1735299 AB - Acute lung injury secondary to aspiration of polyacrylamide, a synthetic polymer used widely in industry, has not been previously described in man or animal. We report the case of a 26-year-old man who aspirated polyacrylamide gel while cleaning it out of a tank truck. Subsequently, severe airway obstruction and lung parenchymal damage developed, and the patient died. At autopsy, numerous polyacrylamide particles were found in the lungs, along with extensive bronchiolar and alveolar damage. JF - Chest AU - Jubran, A AU - Greenberg, S D AU - Solomon, M D AU - Noall, M W AU - Tobin, M J AD - Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr, Veterans Administration Hospital, Loyola University of Chicago Stritch School of Medicine, Maywood, Ill. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 576 EP - 578 VL - 101 IS - 2 SN - 0012-3692, 0012-3692 KW - Acrylic Resins KW - 0 KW - Gels KW - polyacrylamide KW - 9003-05-8 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Lung -- pathology KW - Bronchi -- pathology KW - Male KW - Inhalation KW - Airway Obstruction -- etiology KW - Airway Obstruction -- pathology KW - Accidents, Occupational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72800773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Aspiration+injury+due+to+polyacrylamide.&rft.au=Jubran%2C+A%3BGreenberg%2C+S+D%3BSolomon%2C+M+D%3BNoall%2C+M+W%3BTobin%2C+M+J&rft.aulast=Jubran&rft.aufirst=A&rft.date=1992-02-01&rft.volume=101&rft.issue=2&rft.spage=576&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Structural basis for the barrier abnormality following inhibition of HMG CoA reductase in murine epidermis. AN - 72789166; 1732385 AB - Recent studies have shown that increased epidermal 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase activity is crucial for the barrier recovery response that follows solvent-induced barrier perturbation. Upregulation of this enzyme leads to increased cholesterologenesis, formation and secretion of cholesterol-enriched lamellar bodies, and barrier repair. Topical lovastatin-induced inhibition of HMG CoA reductase activity both delays the acute barrier-repair response, as well as leading to a chronic barrier abnormality when applied repeatedly to intact skin. Presently, we assessed the effects of repeated topical applications of two different specific inhibitors of HMG CoA reductase on barrier function, the lamellar body-secretory system, and stratum corneum intercellular domains, with functional and morphologic parameters. Once-daily applications of lovastatin or fluindostatin (XU62-320; Sandoz) for 4-8 d to intact hairless mouse epidermis produced a progressive abnormality in barrier function (transepidermal water loss greater than 2.0-5.0 in treated versus less than 0.25 mg/cm2/h for weakly active analogues or vehicle controls). The barrier defect was preceded by alterations in lamellar body internal structure and a partial failure of lamellar body secretion into the stratum corneum interstices, further confirmed by enzyme cytochemistry. Moreover, the deposition of abnormal lamellar body contents resulted in the formation of clefts in the intercellular spaces at the stratum granulosum-stratum corneum interface, resulting in increased permeability through these domains shown by lanthanum perfusion. Applications of irritants, even when producing a barrier abnormality, did not alter the lamellar body secretory system. Co-applications of cholesterol with the inhibitors reversed both the barrier abnormality and the abnormalities in the lamellar body secretory system that occur with the inhibitor alone. Finally, membrane bilayer structures in the mid-to-outer stratum corneum of inhibitor-treated specimens appeared normal, but the intercellular domains displayed enormously expanded lacunae. However, because similar dilatations also occurred in vehicle-treated samples, they can be attributed to the vehicle alone. These studies provide further evidence that the inhibitor-induced defect in barrier function a) is initiated by inhibition of HMG CoA reductase; b) can be attributed to defects in both lamellar body structure and deposition with resultant abnormalities in intercellular membrane domains in the lower stratum corneum; and c) is further enhanced by permissive effects of the vehicle on the permeability of the outer stratum corneum. JF - The Journal of investigative dermatology AU - Menon, G K AU - Feingold, K R AU - Mao-Qiang, M AU - Schaude, M AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 209 EP - 219 VL - 98 IS - 2 SN - 0022-202X, 0022-202X KW - Alkanes KW - 0 KW - Fatty Acids, Monounsaturated KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Indoles KW - fluvastatin KW - 4L066368AS KW - Lanthanum KW - 6I3K30563S KW - Cholesterol KW - 97C5T2UQ7J KW - Lovastatin KW - 9LHU78OQFD KW - Lipase KW - EC 3.1.1.3 KW - n-hexadecane KW - F8Z00SHP6Q KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Fatty Acids, Monounsaturated -- pharmacology KW - Lipase -- analysis KW - Mice KW - Lovastatin -- pharmacology KW - Mice, Hairless KW - Histocytochemistry KW - Alkanes -- pharmacology KW - Cholesterol -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Indoles -- pharmacology KW - Up-Regulation KW - Dermatitis -- metabolism KW - Epidermis -- ultrastructure KW - Male KW - Skin -- drug effects KW - Cell Membrane Permeability -- drug effects KW - Skin -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Structural+basis+for+the+barrier+abnormality+following+inhibition+of+HMG+CoA+reductase+in+murine+epidermis.&rft.au=Menon%2C+G+K%3BFeingold%2C+K+R%3BMao-Qiang%2C+M%3BSchaude%2C+M%3BElias%2C+P+M&rft.aulast=Menon&rft.aufirst=G&rft.date=1992-02-01&rft.volume=98&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A randomized phase II trial of continuous infusion interleukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma. AN - 72785785; 1732429 AB - Since 1985, multiple centers have demonstrated that interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells produce durable anticancer responses in patients with metastatic renal cell carcinoma. High-dose recombinant IL-2 (rIL-2) has been administered by intravenous bolus injection (Rosenberg SA, et al: N Engl J Med 313:1485-1492, 1985) and by continuous intravenous infusion (West WH, et al: N Engl J Med 316:898-905, 1987) combined with lymphokine-activated killer (LAK) cells, with both methods producing responses in patients with advanced renal cell carcinoma. The Extramural IL-2/LAK Working Group has conducted a randomized phase II trial of two intravenous high-dose rIL-2 regimens (bolus three times daily or 24-hour continuous infusion) to determine if either one manifests greater anticancer activity or a more acceptable toxicity profile. Ninety-four patients with measurable advanced renal cell carcinoma were enrolled on this study: 46 to the bolus injection arm and 48 to the continuous infusion arm. On both arms, patients underwent a priming phase of rIL-2 administration, four daily lymphocytaphereses to harvest mononuclear cells that were placed in 3- to 4-day culture for generation of LAK cells, and an rIL-2/LAK coadministration phase. Patients were then observed monthly for evidence of response to this therapy and were offered up to two additional courses of treatment every 3 months if evidence of response was detected. Twenty percent of patients on the bolus injection arm experienced objective responses (three complete responses and six partial responses); 15% of patients on the continuous infusion arm responded (two complete responses and five partial responses). Complete responses were durable, persisting for 310+ to 700+ days. The incidence of severe life-threatening toxicities typical of high-dose rIL-2 therapy was similar in both arms (eg, patients with hypotension requiring pressors: bolus 71%, continuous 63%; oliguria less than or equal to 200 mL/8 hours: bolus 65%, continuous 71%). More episodes of fever, infection, and serum alkaline phosphatase elevation were associated with the continuous infusion arm, while more thrombocytopenia occurred on the bolus injection arm. Four patients (three bolus injection, one continuous infusion) died of respiratory and circulatory failure while under treatment. No clinical or laboratory parameter accompanying treatment on either arm was, by univariate or multivariate analysis, associated with an increased likelihood of response. Both methods of high-dose rIL-2/LAK cell administration produce nearly equivalent anticancer activity and toxicity in the treatment of renal cell carcinoma. The ability to predict responding patients based on patient or treatment characteristics is not possible. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Weiss, G R AU - Margolin, K A AU - Aronson, F R AU - Sznol, M AU - Atkins, M B AU - Dutcher, J P AU - Gaynor, E R AU - Boldt, D H AU - Doroshow, J H AU - Bar, M H AD - Extramural IL-2/LAK Working Group, University of Texas Health Science Center/Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio 8284. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 275 EP - 281 VL - 10 IS - 2 SN - 0732-183X, 0732-183X KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Index Medicus KW - Infusions, Intravenous KW - Injections, Intravenous KW - Combined Modality Therapy KW - Humans KW - Aged KW - Drug Evaluation KW - Adult KW - Middle Aged KW - Adolescent KW - Recombinant Proteins -- therapeutic use KW - Female KW - Male KW - Recombinant Proteins -- administration & dosage KW - Kidney Neoplasms -- therapy KW - Interleukin-2 -- administration & dosage KW - Carcinoma, Renal Cell -- therapy KW - Interleukin-2 -- therapeutic use KW - Killer Cells, Lymphokine-Activated -- transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72785785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=A+randomized+phase+II+trial+of+continuous+infusion+interleukin-2+or+bolus+injection+interleukin-2+plus+lymphokine-activated+killer+cells+for+advanced+renal+cell+carcinoma.&rft.au=Weiss%2C+G+R%3BMargolin%2C+K+A%3BAronson%2C+F+R%3BSznol%2C+M%3BAtkins%2C+M+B%3BDutcher%2C+J+P%3BGaynor%2C+E+R%3BBoldt%2C+D+H%3BDoroshow%2C+J+H%3BBar%2C+M+H&rft.aulast=Weiss&rft.aufirst=G&rft.date=1992-02-01&rft.volume=10&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of expression of the leukocyte integrin CD11a (LFA-1) molecule during differentiation of HL-60 cells along the monocyte/macrophage pathway. AN - 72777946; 1730867 AB - The CD11a/CD18 (LFA-1) leukocyte integrin receptor mediates homotypic and heterotypic leukocyte adhesion by binding to one of two defined ligands, ICAM-1 or 2, on the conjugate cell. In this study we investigated the molecular regulation of expression of the CD11a subunit during myeloid differentiation of HL-60 cells. Induction of monocyte/macrophage differentiation of HL-60 promyelocytic leukemia cells with PMA results in an increase in CD11a surface Ag expression and the acquisition of CD11a/CD18-mediated homotypic adherence. These changes are accompanied by a 40-fold increase in CD11a mRNA levels. Nuclear run-on transcription assays indicate that the increase in CD11a mRNA in PMA-induced HL-60 cells is not caused by an increase in CD11a RNA transcription. We assessed the posttranscriptional regulation of CD11a using two methods. By using actinomycin D to block RNA transcription, we demonstrate that the CD11a mRNA half-life in HL-60 cells is prolonged after PMA treatment. Inhibition of protein synthesis with cycloheximide also results in enhanced expression of CD11a mRNA in HL-60 cells without increasing CD11a transcription. These findings indicate that, in HL-60 cells induced with PMA to differentiate along the monocyte/macrophage pathway, CD11a expression is regulated primarily at the posttranscriptional level by a labile protein. Identification of the specific CD11a RNA sequences, and the proteins that bind to these sequences may provide insight into lineage commitment during human monocyte/macrophage differentiation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Back, A L AU - Gollahon, K A AU - Hickstein, D D AD - Medical Research Division, Seattle Veterans Administration Medical Center, WA 98108. Y1 - 1992/02/01/ PY - 1992 DA - 1992 Feb 01 SP - 710 EP - 714 VL - 148 IS - 3 SN - 0022-1767, 0022-1767 KW - Lymphocyte Function-Associated Antigen-1 KW - 0 KW - RNA, Messenger KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Blotting, Northern KW - Tumor Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Gene Expression KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Transcription, Genetic KW - Leukemia, Myeloid -- pathology KW - Cell Membrane -- metabolism KW - RNA, Messenger -- genetics KW - Cell Differentiation -- drug effects KW - Lymphocyte Function-Associated Antigen-1 -- genetics KW - Monocytes -- physiology KW - Macrophages -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72777946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Regulation+of+expression+of+the+leukocyte+integrin+CD11a+%28LFA-1%29+molecule+during+differentiation+of+HL-60+cells+along+the+monocyte%2Fmacrophage+pathway.&rft.au=Back%2C+A+L%3BGollahon%2C+K+A%3BHickstein%2C+D+D&rft.aulast=Back&rft.aufirst=A&rft.date=1992-02-01&rft.volume=148&rft.issue=3&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-19 N1 - Date created - 1992-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of Semantic Context and Expectancy in a Lexical Decision and Naming Task AN - 85548567; 9207613 AB - A single-word priming study was used to investigate differences in the sensitivity of the lexical decision & naming tasks to postlexical processes. Relatedness probability was manipulated with an "induction set" presented to Ss (N = 48, aged 26-61) prior to stimuli onset. In the naming task, an induction set with a high probability of related word pairs produced both facilitation & inhibition; a high probability of unrelated word pairs resulted in similar response times to all word targets. Significant facilitation was found for the lexical decision task, regardless of the induction set relatedness. Data suggest that under some circumstances the naming task is sensitive to postrecognition contextual effects. They do not support the use of the lexical decision & naming tasks as methodological tools for a priori distinguishing pre- & postcontextual effects in word recognition. 3 Tables, 10 References. Adapted from the source document JF - The Bulletin of the Psychonomic Society AU - McGlinchey-Berroth, Regina AU - Milberg, William P AD - Geriatric Research Education & Clinical Center Brocton/West Roxbury Veterans Administration Medical Center, 1400 VFW Parkway West Roxbury MA 02132 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 421 EP - 424 VL - 30 IS - 5 SN - 0090-5054, 0090-5054 KW - lexical decision/naming tasks, postlexical processes influences differences KW - empirical data KW - adults aged 26-61 KW - Verbal Tasks (93800) KW - Context (15250) KW - Semantic Processing (76760) KW - Word Recognition (98200) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85548567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Bulletin+of+the+Psychonomic+Society&rft.atitle=Effects+of+Semantic+Context+and+Expectancy+in+a+Lexical+Decision+and+Naming+Task&rft.au=McGlinchey-Berroth%2C+Regina%3BMilberg%2C+William+P&rft.aulast=McGlinchey-Berroth&rft.aufirst=Regina&rft.date=1992-01-01&rft.volume=30&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=The+Bulletin+of+the+Psychonomic+Society&rft.issn=00905054&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BPNSBY N1 - SubjectsTermNotLitGenreText - Word Recognition (98200); Semantic Processing (76760); Verbal Tasks (93800); Context (15250) ER - TY - JOUR T1 - Two doses of omeprazole versus placebo in symptomatic erosive esophagitis: the U.S. Multicenter Study. AN - 85243412; pmid-1727744 AB - Two hundred thirty patients with reflux symptoms and endoscopically proven erosive esophagitis were enrolled from 15 U.S. centers into a randomized, double-blind, dose-ranging study comparing placebo with omeprazole, 20 or 40 mg given once daily in the morning. Esophagitis grade 2 was present in 44% of patients, grade 3 in 37% of patients, and grade 4 in 19% of patients. Endpoints, defined as complete relief of heartburn and complete esophageal mucosal healing, were assessed after 4 and 8 weeks of treatment. Both omeprazole doses were significantly superior to placebo in complete endoscopic healing. After 8 weeks of treatment, 73.5% of patients in the 20-mg omeprazole group and 74.7% in the 40-mg omeprazole group, compared with 14.0% in the placebo group, had complete healing of the esophageal mucosa. At the end of the study, complete relief of daytime heartburn was obtained in 79.5% of patients in the 20-mg omeprazole group, 81.6% in the 40-mg omeprazole group, and 37.2% in the placebo group (P less than or equal to 0.05). Complete relief of nighttime heartburn was noted by 79.5% of patients in the 20-mg omeprazole group, 85.1% in the 40-mg omeprazole group, and 34.9% in the placebo group (P less than or equal to 0.05). The median time to complete relief of daytime and nighttime heartburn occurred earlier in the 40-mg group than in the 20-mg group (9 vs. 17 days and 9 vs. 20 days, respectively); however, these differences were not statistically significant. Relief of acid regurgitation and dysphagia also occurred earlier in the 40-mg group. Omeprazole was well tolerated in this group of patients. No unexpected adverse experiences occurred. The results of this study confirm those of six multicenter, international trials in which omeprazole in doses of 20-60 mg provided a degree of esophageal mucosal healing and complete relief of reflux symptoms superior to any other medical treatment. JF - Gastroenterology AU - Sontag, S J AU - Hirschowitz, B I AU - Holt, S AU - Robinson, M G AU - Behar, J AU - Berenson, M M AU - McCullough, A AU - Ippoliti, A F AU - Richter, J E AU - Ahtaridis, G AD - Veterans Administration Hospital, Hines, Illinois. PY - 1992 SP - 109 EP - 118 VL - 102 IS - 1 SN - 0016-5085, 0016-5085 KW - Dose-Response Relationship, Drug KW - Human KW - Aged KW - Omeprazole KW - Esophagoscopy KW - Esophagitis KW - Stomach Diseases KW - Aged, 80 and over KW - Adult KW - Middle Age KW - Support, Non-U.S. Gov't KW - Placebos KW - Antacids KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85243412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Two+doses+of+omeprazole+versus+placebo+in+symptomatic+erosive+esophagitis%3A+the+U.S.+Multicenter+Study.&rft.au=Sontag%2C+S+J%3BHirschowitz%2C+B+I%3BHolt%2C+S%3BRobinson%2C+M+G%3BBehar%2C+J%3BBerenson%2C+M+M%3BMcCullough%2C+A%3BIppoliti%2C+A+F%3BRichter%2C+J+E%3BAhtaridis%2C+G&rft.aulast=Sontag&rft.aufirst=S&rft.date=1992-01-01&rft.volume=102&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Periventricular white matter changes and oropharyngeal swallowing in normal individuals. AN - 85154881; pmid-1499355 AB - Cranial magnetic resonance imaging (MRI) has revealed patchy periventricular white matter lesions or "unidentified bright objects" (UBOs) in otherwise neurologically intact individuals. Quantitative videofluoroscopic swallowing evaluations and cranial MRI examinations were studied in 49 neurologically normal volunteers (ages 43 to 79 years). Total swallowing duration (TSD) and its subcomponents of oral transit duration (OTD), stage transition duration (STD), and pharyngeal response duration were measured for liquid and semisolid swallows. MRIs were graded from 0, or no UBOs, to 3, or multiple and confluent lesions. The effect of the presence of UBOs on swallowing durational measures and risk factors was analyzed with age differences accounted for statistically (ANCOVA). TSD and OTD for semisolids were significantly differentiated by MRI score (P less than 0.009 and P less than 0.047, respectively). That is, a demonstrable effect was found for an increased number of UBOs on duration of oropharyngeal swallowing in normal individuals. JF - Dysphagia AU - Levine, R AU - Robbins, J A AU - Maser, A AD - Department of Neurology, William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin 53705. PY - 1992 SP - 142 EP - 147 VL - 7 IS - 3 SN - 0179-051X, 0179-051X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85154881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Periventricular+white+matter+changes+and+oropharyngeal+swallowing+in+normal+individuals.&rft.au=Levine%2C+R%3BRobbins%2C+J+A%3BMaser%2C+A&rft.aulast=Levine&rft.aufirst=R&rft.date=1992-01-01&rft.volume=7&rft.issue=3&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tolerance, withdrawal, and supersensitivity to dopamine mediated cues in a drug-drug discrimination. AN - 75541675; 1365673 AB - Rats were trained to discriminate between 0.25 mg/kg amphetamine (AMPH) and 0.03 mg/kg haloperidol (HAL) in a two-lever drug discrimination task. In order to test for a drug-induced withdrawal state, animals were assigned to one of three chronic treatment groups and given injections of AMPH, HAL, or distilled water (DW) for 10 consecutive days. Subjects from each treatment condition were then tested at 24, 48, or 72 h after the final injection. At the 24 h retest interval, subjects injected with AMPH responded as though administered an acute dose of HAL (0.028 mg/kg) and subjects injected with chronic HAL responded as though administered an acute dose of AMPH (0.15 mg/kg). By 72 h choice behavior had returned to pretreatment values. To determine whether the rebound observed after 10 days of drug treatment was present after a single injection, independent groups of subjects were injected with single doses of either 10 mg/kg AMPH or 1.0 mg/kg HAL and then retested from 4 h to 48 h later. Single doses of both AMPH and HAL produced significant rebounds that peaked between 20 h (AMPH) and 24 h (HAL) following administration. In a third experiment, animals were tested with or without acute doses of drug following pretreatment with either HAL or AMPH. Receptor supersensitivity accounts for the tolerance observed to HAL 24 h after treatment with 1.0 mg/kg HAL, whereas receptor subsensitivity accounts for the tolerance observed 20 h after treatment with 10 mg/kg AMPH. JF - Psychopharmacology AU - Barrett, R J AU - White, D K AU - Caul, W F AD - Veterans Administration Medical Center, Department of Psychology, Vanderbilt University, Nashville, TN. Y1 - 1992 PY - 1992 DA - 1992 SP - 63 EP - 67 VL - 109 IS - 1-2 SN - 0033-3158, 0033-3158 KW - Haloperidol KW - J6292F8L3D KW - Dextroamphetamine KW - TZ47U051FI KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Drug Tolerance KW - Animals KW - Rats, Sprague-Dawley KW - Haloperidol -- pharmacology KW - Male KW - Dextroamphetamine -- pharmacology KW - Discrimination (Psychology) -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Discrimination (Psychology) -- physiology KW - Dopamine -- physiology KW - Cues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75541675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Tolerance%2C+withdrawal%2C+and+supersensitivity+to+dopamine+mediated+cues+in+a+drug-drug+discrimination.&rft.au=Barrett%2C+R+J%3BWhite%2C+D+K%3BCaul%2C+W+F&rft.aulast=Barrett&rft.aufirst=R&rft.date=1992-01-01&rft.volume=109&rft.issue=1-2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-23 N1 - Date created - 1995-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic encephalopathy: a disorder in glial-neuronal communication. AN - 73533611; 1283790 JF - Progress in brain research AU - Norenberg, M D AU - Neary, J T AU - Bender, A S AU - Dombro, R S AD - Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL. Y1 - 1992 PY - 1992 DA - 1992 SP - 261 EP - 269 VL - 94 SN - 0079-6123, 0079-6123 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Ion Channels KW - Receptors, GABA-A KW - Ammonia KW - 7664-41-7 KW - Glycogen KW - 9005-79-2 KW - Cyclic AMP KW - E0399OZS9N KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Receptors, GABA-A -- physiology KW - Humans KW - Glial Fibrillary Acidic Protein -- metabolism KW - Cell Size -- drug effects KW - Cytoskeleton -- drug effects KW - Ion Channels -- metabolism KW - Glycogen -- metabolism KW - Cells, Cultured KW - Signal Transduction -- drug effects KW - Calcium -- physiology KW - Cyclic AMP -- metabolism KW - Receptors, GABA-A -- drug effects KW - Cytoskeleton -- ultrastructure KW - Brain Edema -- pathology KW - Astrocytes -- drug effects KW - Ammonia -- toxicity KW - Hepatic Encephalopathy -- pathology KW - Astrocytes -- pathology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73533611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+brain+research&rft.atitle=Hepatic+encephalopathy%3A+a+disorder+in+glial-neuronal+communication.&rft.au=Norenberg%2C+M+D%3BNeary%2C+J+T%3BBender%2C+A+S%3BDombro%2C+R+S&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1992-01-01&rft.volume=94&rft.issue=&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Progress+in+brain+research&rft.issn=00796123&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-17 N1 - Date created - 1993-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dental office recordkeeping requirements under the MOSH/OSHA bloodborne pathogens standard. AN - 73500774; 1289458 JF - Journal of the Maryland State Dental Association AU - Goodman, H S AU - Ward, M A AU - DePaola, L G AD - Veterans Administration Medical Center, Perry Point, MD. Y1 - 1992 PY - 1992 DA - 1992 SP - 17 EP - 19 VL - 35 IS - 1 SN - 0025-4355, 0025-4355 KW - Dentistry KW - United States KW - Maryland KW - United States Occupational Safety and Health Administration -- legislation & jurisprudence KW - Practice Management, Dental -- legislation & jurisprudence KW - Dentists KW - Dental Records KW - Occupational Exposure -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73500774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Maryland+State+Dental+Association&rft.atitle=Dental+office+recordkeeping+requirements+under+the+MOSH%2FOSHA+bloodborne+pathogens+standard.&rft.au=Goodman%2C+H+S%3BWard%2C+M+A%3BDePaola%2C+L+G&rft.aulast=Goodman&rft.aufirst=H&rft.date=1992-01-01&rft.volume=35&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Maryland+State+Dental+Association&rft.issn=00254355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-22 N1 - Date created - 1993-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cocaine and speedball users: differences in psychopathology. AN - 73435064; 1479627 AB - Affective distress and related symptoms associated with co-injected cocaine and opioid ("speedball") use are incompletely explored, and the extent to which they diverge from problems shown by cocaine abusers who do not prefer opioids is unknown. This investigation compared groups of speedball and non-speedball cocaine users on global measures of depression and anxiety and modal groupings of personality characteristics measured by the MMPI. Compared to men who use cocaine without opioids, compulsive speedball users evidenced significantly greater problems with depression, trait anxiety, and related symptomatology, and were more uniformly characterized by modal profiles reflecting severe psychopathology and maladjustment. These results agree with descriptions of severe pathology associated with speedball use. JF - Journal of substance abuse treatment AU - Malow, R M AU - West, J A AU - Corrigan, S A AU - Pena, J M AU - Lott, W C AD - Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1992 PY - 1992 DA - 1992 SP - 287 EP - 291 VL - 9 IS - 4 SN - 0740-5472, 0740-5472 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Anxiety -- psychology KW - Depression -- rehabilitation KW - Combined Modality Therapy KW - Anxiety -- rehabilitation KW - Humans KW - Depression -- psychology KW - Adult KW - Antisocial Personality Disorder -- rehabilitation KW - Antisocial Personality Disorder -- psychology KW - Male KW - Euphoria -- drug effects KW - MMPI KW - Heroin Dependence -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Heroin Dependence -- psychology KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73435064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Cocaine+and+speedball+users%3A+differences+in+psychopathology.&rft.au=Malow%2C+R+M%3BWest%2C+J+A%3BCorrigan%2C+S+A%3BPena%2C+J+M%3BLott%2C+W+C&rft.aulast=Malow&rft.aufirst=R&rft.date=1992-01-01&rft.volume=9&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationships between various uses of antineoplastic drug-interaction terms. AN - 73411467; 1333367 AB - In in vitro testing, no pharmacologic synergism has been found for the combination of cisplatin and etoposide in P388 leukemia in contrast to the demonstration of therapeutic synergism in the same model. No pharmacologic synergism has been found for the same combination in the treatment of four small-cell lung-cancer cell lines, although clinical results obtained using this combination in small-cell lung cancer and other cancers suggest a therapeutic advantage. The popular concept of synergy, implying a therapeutic advantage, is different from the pharmacologic meaning, which generally implies that less drug is required in a combination for an equal effect. Therapeutic advantage may be obtained regardless of whether drugs are synergistic in the pharmacologic sense in the treatment of a tumor. To gain a more comprehensive insight into concepts of drug interaction, it is important to recognize that the type of drug interaction seen is dependent on the drug doses used and may vary with the treatment of different cell lines. All of these factors complicate the use of the word synergism, or any associated term, in a categorical manner to describe the effects of combinations of antineoplastic drugs. JF - Cancer chemotherapy and pharmacology AU - Wampler, G L AU - Carter, W H AU - Campbell, E D AU - Keefe, P A AD - Department of Medicine, Richmond Veterans Administration Medical Center, Virginia 23249. Y1 - 1992 PY - 1992 DA - 1992 SP - 111 EP - 117 VL - 31 IS - 2 SN - 0344-5704, 0344-5704 KW - Antineoplastic Agents KW - 0 KW - Etoposide KW - 6PLQ3CP4P3 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Etoposide -- pharmacology KW - Animals KW - Tumor Cells, Cultured KW - Leukemia P388 -- drug therapy KW - Humans KW - Lung Neoplasms -- drug therapy KW - Cisplatin -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Terminology as Topic KW - Drug Synergism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73411467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Relationships+between+various+uses+of+antineoplastic+drug-interaction+terms.&rft.au=Wampler%2C+G+L%3BCarter%2C+W+H%3BCampbell%2C+E+D%3BKeefe%2C+P+A&rft.aulast=Wampler&rft.aufirst=G&rft.date=1992-01-01&rft.volume=31&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-31 N1 - Date created - 1992-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of aluminum on Na-K-ATPase activity in vitro. AN - 73402591; 1333938 JF - Contributions to nephrology AU - Adler, A J AU - Caruso, C AU - Berlyne, G M AD - Department of Medicine (111), Brooklyn Veterans Administration Hospital, N.Y. Y1 - 1992 PY - 1992 DA - 1992 SP - 118 EP - 126 VL - 100 SN - 0302-5144, 0302-5144 KW - Phosphates KW - 0 KW - Ouabain KW - 5ACL011P69 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Aluminum KW - CPD4NFA903 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Rats KW - Phosphates -- metabolism KW - Brain -- enzymology KW - Animals KW - Hydrogen-Ion Concentration KW - In Vitro Techniques KW - Kidney -- enzymology KW - Dogs KW - Ouabain -- pharmacology KW - Adenosine Triphosphate -- pharmacology KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Aluminum -- metabolism KW - Aluminum -- toxicity KW - Aluminum -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73402591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=The+effect+of+aluminum+on+Na-K-ATPase+activity+in+vitro.&rft.au=Adler%2C+A+J%3BCaruso%2C+C%3BBerlyne%2C+G+M&rft.aulast=Adler&rft.aufirst=A&rft.date=1992-01-01&rft.volume=100&rft.issue=&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-08 N1 - Date created - 1993-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mr R: a case study of withdrawal. AN - 73256384; 1330103 AB - This case study describes a patient with a long-time history of polysubstance abuse and dependence who was admitted to the hospital for detoxification from, and treatment for, his addictions. Despite physiological dependence upon the long-acting narcotic methadone, the patient did not show evidence of withdrawal from this agent until weeks after it was discontinued. This case emphasizes the psychological component of narcotic withdrawal. JF - Behavioral medicine (Washington, D.C.) AU - Dennison, S J AD - Chemical Dependency Treatment Section, Roudebush Veterans Administration Hospital, Indianapolis. Y1 - 1992 PY - 1992 DA - 1992 SP - 139 EP - 140 VL - 18 IS - 3 SN - 0896-4289, 0896-4289 KW - Cocaine KW - I5Y540LHVR KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Placebo Effect KW - Substance Abuse Treatment Centers KW - Humans KW - Neurologic Examination -- drug effects KW - Middle Aged KW - Clonidine -- therapeutic use KW - Male KW - Alcoholism -- rehabilitation KW - Methadone -- adverse effects KW - Methadone -- therapeutic use KW - Substance Withdrawal Syndrome -- diagnosis KW - Opioid-Related Disorders -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73256384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.atitle=Mr+R%3A+a+case+study+of+withdrawal.&rft.au=Dennison%2C+S+J&rft.aulast=Dennison&rft.aufirst=S&rft.date=1992-01-01&rft.volume=18&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.issn=08964289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-08 N1 - Date created - 1992-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of protein kinase C in constrictor responses of the rat basilar artery in vivo. AN - 73121523; 1501132 AB - 1. The goal of this study was to determine the effects of activation and inhibition of protein kinase C on the rat basilar artery in vivo. 2. The diameter of the basilar artery was measured through a craniotomy in rats anaesthetized with pentobarbitone sodium (50 mg kg-1, I.P., supplemented with 20 mg kg-1 h-1). Diameters were measured under control conditions and during topical application of various agonists, both alone and in the presence of antagonists. 3. Serotonin (5-HT) produced concentration-related constriction of the basilar artery (baseline diameter = 234 +/- 9 microns, mean +/- S.E.M.), which was inhibited by the 5-HT2 receptor antagonist LY53857. 4. Sphingosine (10(-6) M), a protein kinase C inhibitor which binds to the regulatory site of protein kinase C, inhibited the response to 10(-8) M-serotonin (-19 +/- 2% before vs. -3 +/- 2% during sphingosine, P less than 0.05). In contrast, constrictor responses to prostaglandin F2 alpha to (PGF2 alpha; 10(-6) M) were not inhibited by sphingosine (-16 +/- 2% before vs. -18 +/- 2% during sphingosine, P greater than 0.05). 5. H-7 (10(-9) M), another protein kinase C inhibitor, which binds to the catalytic site of protein kinase C, also inhibited constriction of the basilar artery in response to serotonin, but not prostaglandin F2 alpha. 6. Phorbol 12,13-dibutyrate (PDBu, 10(-8) M), which activates protein kinase C, produced slowly developing constriction of the basilar artery. PDBu-induced vasoconstriction (-33 +/- 2%) was attenuated by sphingosine (-11 +/- 4% during sphingosine, P less than 0.05) and H-7 (-1.5 +/- 5% during H-7, P less than 0.05). 7. In summary, activation of protein kinase C appears to mediate vasoconstrictor responses of the basilar artery to serotonin, but not PGF2 alpha. JF - The Journal of physiology AU - Murray, M A AU - Faraci, F M AU - Heistad, D D AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 169 EP - 179 VL - 445 SN - 0022-3751, 0022-3751 KW - Ergolines KW - 0 KW - Isoquinolines KW - Piperazines KW - Serotonin Antagonists KW - Serotonin KW - 333DO1RDJY KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - LY 53857 KW - 60634-51-7 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Dinoprost KW - B7IN85G1HY KW - Protein Kinase C KW - EC 2.7.11.13 KW - Sphingosine KW - NGZ37HRE42 KW - Index Medicus KW - Serotonin -- pharmacology KW - Animals KW - Serotonin Antagonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Ergolines -- pharmacology KW - Dinoprost -- pharmacology KW - Enzyme Activation -- physiology KW - Basilar Artery -- drug effects KW - Piperazines -- pharmacology KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Isoquinolines -- pharmacology KW - Basilar Artery -- physiology KW - Sphingosine -- pharmacology KW - Basilar Artery -- anatomy & histology KW - Male KW - Vasoconstriction -- physiology KW - Vasoconstriction -- drug effects KW - Protein Kinase C -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73121523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+physiology&rft.atitle=Role+of+protein+kinase+C+in+constrictor+responses+of+the+rat+basilar+artery+in+vivo.&rft.au=Murray%2C+M+A%3BFaraci%2C+F+M%3BHeistad%2C+D+D&rft.aulast=Murray&rft.aufirst=M&rft.date=1992-01-01&rft.volume=445&rft.issue=&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+physiology&rft.issn=00223751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-17 N1 - Date created - 1992-09-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1986 Jun 6;45(5):631-2 [3708690] J Physiol. 1987 Jun;387:115-23 [3116212] Nature. 1984 Apr 19-25;308(5961):693-8 [6232463] Biochem Biophys Res Commun. 1984 Apr 30;120(2):481-5 [6610416] J Biol Chem. 1982 Jul 10;257(13):7847-51 [7085651] J Cereb Blood Flow Metab. 1991 Jan;11(1):143-9 [1983998] Br J Pharmacol. 1991 Feb;102(2):415-21 [2015423] Am J Physiol. 1990 Nov;259(5 Pt 2):H1586-94 [2240255] Life Sci. 1987 Aug 31;41(9):1051-64 [2441225] Annu Rev Pharmacol Toxicol. 1989;29:71-110 [2543275] Am J Physiol. 1989 Sep;257(3 Pt 2):H799-803 [2675632] J Biol Chem. 1988 Oct 25;263(30):15241-4 [2844804] J Pharmacol Exp Ther. 1986 Aug;238(2):480-5 [3016238] Eur J Pharmacol. 1987 Apr 29;136(3):325-32 [3038568] J Biol Chem. 1987 Oct 5;262(28):13620-6 [3115982] J Physiol. 1987 Nov;392:333-48 [3446783] J Biol Chem. 1986 Sep 25;261(27):12604-9 [3462188] J Pharmacol Exp Ther. 1985 Nov;235(2):319-23 [4057073] Biochem J. 1984 Jun 1;220(2):345-60 [6146314] Biochemistry. 1984 Oct 9;23(21):5036-41 [6238627] Neuropharmacology. 1984 Oct;23(10):1223-5 [6521858] Brain Res. 1983 Jan 24;259(2):327-30 [6824943] J Pharmacol Exp Ther. 1981 Aug;218(2):421-5 [7252841] J Cereb Blood Flow Metab. 1991 Jan;11(1):135-42 [1845765] J Pharmacol Exp Ther. 1990 Oct;255(1):66-73 [2213572] J Pharmacol Exp Ther. 1985 Aug;234(2):442-6 [2410594] J Pharmacol Exp Ther. 1989 Jul;250(1):44-51 [2545867] J Cereb Blood Flow Metab. 1989 Oct;9(5):713-6 [2777937] Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):98-103 [2944005] FASEB J. 1987 Sep;1(3):177-85 [3040504] J Pharmacol Exp Ther. 1981 Jul;218(1):217-30 [6113280] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stages of change for smoking cessation among former problem drinkers: a cross-sectional analysis. AN - 73113270; 1504636 AB - Recent research suggests that problem drinkers are less successful in quitting smoking. Stages of change, decisional balance, and self-efficacy measures were used to assess readiness for smoking cessation in a cross-sectional sample of former problem drinkers who were current smokers. As was expected, a very high percentage of recovering problem drinkers had been or currently were regular smokers. Distributions across the stages of change and relationships between stages and decisional balance in this problem drinker sample was found to be similar to results from more general smoking populations. Of those who had quit both smoking and alcohol, 62% quit drinking before or at the same time as smoking (53% before; 9% simultaneous). Those who quit drinking before or at the same time as smoking were characterized by a more problematic alcohol history. A stages-of-change perspective with this group is discussed, as are new avenues for future research with such populations. JF - Journal of substance abuse AU - Snow, M G AU - Prochaska, J O AU - Rossi, J S AD - University of Connecticut Health Center, West Haven Veterans Administration Medical Center, CT 06516. Y1 - 1992 PY - 1992 DA - 1992 SP - 107 EP - 116 VL - 4 IS - 2 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Generalization (Psychology) KW - Adult KW - Temperance -- psychology KW - Alcohol Drinking -- psychology KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Smoking Cessation -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73113270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=Stages+of+change+for+smoking+cessation+among+former+problem+drinkers%3A+a+cross-sectional+analysis.&rft.au=Snow%2C+M+G%3BProchaska%2C+J+O%3BRossi%2C+J+S&rft.aulast=Snow&rft.aufirst=M&rft.date=1992-01-01&rft.volume=4&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-23 N1 - Date created - 1992-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiology considerations in peptic ulcer disease. AN - 73112405; 1498525 AB - Peptic ulcer disease is a common clinical problem. The lifetime risk of peptic ulcer disease is at least 10%. Millions of Americans are affected each year, imposing a major economic burden on the health care system. The overall hospitalization and mortality rates for peptic ulcer disease seem to have decreased substantially over the past few decades. There is much to suggest, however, that these changes were occurring even before effective medical therapy became available. In addition, other influences, such as increasing age of the population at risk, changes in smoking prevalence, and increasing use of nonsteroidal anti-inflammatory drugs, have impacted on the changing epidemiology of peptic ulcer disease. Hospitalization rates for patients with complications of peptic ulcer disease have remained relatively stable or, especially in the case of elderly women with gastric ulcers, increased significantly in recent years. Understanding the epidemiology of peptic ulcer disease will allow improved assessment of the effects of medical and surgical therapy and, hopefully, provide better clues to the etiology of this diverse group of diseases. JF - Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians AU - Schlesinger, P K AU - Robinson, B AU - Layden, T J AD - Department of Medicine, Veterans Administration West Side Medical Center, Chicago, IL. Y1 - 1992 PY - 1992 DA - 1992 SP - 70 EP - 77 VL - 3 IS - 3 SN - 1048-9886, 1048-9886 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - Office Visits KW - Hospitalization KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Smoking -- adverse effects KW - United States -- epidemiology KW - Male KW - Female KW - Peptic Ulcer -- epidemiology KW - Peptic Ulcer -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73112405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.atitle=Epidemiology+considerations+in+peptic+ulcer+disease.&rft.au=Schlesinger%2C+P+K%3BRobinson%2C+B%3BLayden%2C+T+J&rft.aulast=Schlesinger&rft.aufirst=P&rft.date=1992-01-01&rft.volume=3&rft.issue=3&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.issn=10489886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-17 N1 - Date created - 1992-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurotoxic effects of platinum compounds in cultured dorsal root ganglion cells. AN - 73060847; 1625039 AB - The neurotoxic cancer chemotherapeutic agent cis-diamminedichloroplatinum (II) (cis-platin) was tested in a model system of cultured embryonic chick dorsal root ganglion cells, in order to investigate cellular mechanisms of toxicity. At 7.5 ug/ml, the drug caused mild toxicity. At doses of 75 ug/ml, cis-platin was toxic to cultures in 6 hours, in both neuronal and non-neuronal cell populations. After 24 hours of incubation with 75 ug/ml cis-platin, there was extensive cell death. The trans isomer of the drug, trans-platin, was less toxic than cis-platin at similar doses, causing less severe damage to the cells as well as less cell death. With both drugs, abnormalities in patterns of nuclear staining were prominent, whereas neuronal cell membrane staining patterns were less affected. Both drugs seemed to affect non-neuronal cells to a greater extent than neurons. Ultrastructural findings with both drugs included nucleolar segregation; mitochondrial changes were nonspecific. In this in vitro system, both cis- and trans-platin are toxic. The toxicity appears to predominantly affect the nucleus, and to preferentially involve non-neuronal cells. JF - Journal of experimental pathology AU - Blisard, K S AU - Rogers, S L AU - Alexander, S AU - Harrington, D A AD - Research Service, Veterans' Administration Medical Center, Albuquerque, NM. Y1 - 1992 PY - 1992 DA - 1992 SP - 65 EP - 74 VL - 6 IS - 1-2 SN - 0730-8485, 0730-8485 KW - transplatin KW - 14913-33-8 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Chick Embryo KW - Cell Death -- drug effects KW - Time Factors KW - Ganglia, Spinal -- cytology KW - Cisplatin -- toxicity KW - Cisplatin -- pharmacology KW - Ganglia, Spinal -- drug effects KW - Cisplatin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73060847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+pathology&rft.atitle=Neurotoxic+effects+of+platinum+compounds+in+cultured+dorsal+root+ganglion+cells.&rft.au=Blisard%2C+K+S%3BRogers%2C+S+L%3BAlexander%2C+S%3BHarrington%2C+D+A&rft.aulast=Blisard&rft.aufirst=K&rft.date=1992-01-01&rft.volume=6&rft.issue=1-2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+pathology&rft.issn=07308485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-07 N1 - Date created - 1992-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Measurement issues in the evaluation of experimental treatment interventions. AN - 73048739; 1620195 AB - The final discussion of followup measurement highlights earlier discussions of patient and treatment measurement. Followup is the best assessment of the efficacy of a treatment intervention. Therefore, it is critical to have a clear set of baseline measures on the patient in those areas that are expected to be able to improve with the intervention and to repeat these measures at followup to assess improvement and outcome. The measures that are collected at followup are essentially identical to the measures that were collected at the time of treatment admission but in abbreviated form. However, the same methodological issues, techniques, and considerations apply. As at the time of the initial assessment, the patient should be measured in all those areas that are expected to be changed, the patient should be assessed with multiple methods (interview questionnaire and objective laboratory data), and all care should be taken to assure the patient that the information will be treated in a professional manner and that her privacy and confidentiality will be protected. An effective posttreatment evaluation requires effective tracking, locating, and reinterviewing each patient following treatment. The ability to recontact these patients after treatment is almost entirely dependent on the level of information, patient preparation, and interagency cooperation established during the time the patient was in treatment. Followup is an important but difficult job that must be coordinated from the very start of treatment and must involve the patient, followup staff, clinical program, and sponsoring agency or agencies. JF - NIDA research monograph AU - McLellan, A T AD - Penn-VA Center for Studies of Addiction, Philadelphia Veterans Administration Medical Center, PA 19104. Y1 - 1992 PY - 1992 DA - 1992 SP - 18 EP - 30 VL - 117 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Female KW - Pregnancy KW - Substance-Related Disorders -- therapy KW - Pregnancy Complications -- therapy KW - Pregnancy Complications -- prevention & control KW - Substance-Related Disorders -- complications KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73048739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Measurement+issues+in+the+evaluation+of+experimental+treatment+interventions.&rft.au=McLellan%2C+A+T&rft.aulast=McLellan&rft.aufirst=A&rft.date=1992-01-01&rft.volume=117&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-06 N1 - Date created - 1992-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypothalamic-pituitary function during alcohol exposure and withdrawal and cocaine exposure. AN - 72954739; 1317048 AB - This chapter examines the neuroendocrine effects of acute exposure to and withdrawal from alcohol and cocaine, with special emphasis on the hypothalamic-pituitary-adrenal (HPA) axis. We present the results from two preliminary controlled inpatient studies that document HPA dysfunction during acute exposure to alcohol and cocaine and during withdrawal from alcohol. We discuss the methodological approach of these studies in comparison to related attempts in the literature to use measures of thyroid and prolactin regulation to predict risk of relapse to alcohol and cocaine use, respectively. Our data and the results of related studies are presented in the context of a proposed index of HPA axis dysfunction that may provide a useful clinical measure of susceptibility to relapse during protracted abstinence from alcohol or cocaine. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Wilkins, J N AU - Gorelick, D A AU - Nademanee, K AU - Taylor, A AU - Herzberg, D S AD - Substance Abuse Service, West Los Angeles Veterans Administration Medical Center, Brentwood Division, California 90073. Y1 - 1992 PY - 1992 DA - 1992 SP - 57 EP - 71 VL - 10 SN - 0738-422X, 0738-422X KW - Ethanol KW - 3K9958V90M KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Cocaine KW - I5Y540LHVR KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Alcoholic Intoxication -- rehabilitation KW - Substance Abuse Treatment Centers KW - Double-Blind Method KW - Alcoholic Intoxication -- physiopathology KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Hydrocortisone -- blood KW - Adrenocorticotropic Hormone -- blood KW - Substance-Related Disorders -- physiopathology KW - Alcoholism -- rehabilitation KW - Hypothalamo-Hypophyseal System -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Substance-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects KW - Ethanol -- adverse effects KW - Ethanol -- pharmacokinetics KW - Substance Withdrawal Syndrome -- rehabilitation KW - Pituitary-Adrenal System -- physiopathology KW - Cocaine -- pharmacokinetics KW - Alcoholism -- physiopathology KW - Pituitary-Adrenal System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72954739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Hypothalamic-pituitary+function+during+alcohol+exposure+and+withdrawal+and+cocaine+exposure.&rft.au=Wilkins%2C+J+N%3BGorelick%2C+D+A%3BNademanee%2C+K%3BTaylor%2C+A%3BHerzberg%2C+D+S&rft.aulast=Wilkins&rft.aufirst=J&rft.date=1992-01-01&rft.volume=10&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-22 N1 - Date created - 1992-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol consumption and mortality in an American male population: recovering the U-shaped curve--findings from the normative Aging Study. AN - 72872043; 1556854 AB - Several prospective studies have suggested that moderate alcohol consumption may offer protection against total and coronary heart disease (CHD) mortality. These studies have been criticized for failing to control for changes in drinking and the influence of comorbidity on consumption decisions. In the present study, we examined whether rates of death from all causes and from CHD were related to overall consumption as well as variability in or problems with drinking. In 1973, a drinking questionnaire was completed by 1,823 male subjects participating in a longitudinal study who were prescreened for absence of serious or chronic disease. After 12 years of follow-up per subject (21,716 man years of follow-up in all), 159 men have died, 74 from CHD. Incidence rates of overall mortality were lowest for moderate drinkers in each of three age groups. CHD death rates for moderate drinkers were similar to those of non-drinkers except in the oldest men where rates were lower for moderate drinkers. Proportional hazards models testing several measures of consumption consistently showed moderate or regular drinkers to have lower risk of death than teetotalers. Regular drinkers had lower overall and CHD mortality than lifetime abstainers. For all-cause and CHD mortality, drinking heavily in the past, ever having tried to quit drinking and having had problems with alcohol were not related to increased risk. These results lend support to the hypothesis of the beneficial effect of moderate drinking, with respect to mortality. JF - Journal of studies on alcohol AU - de Labry, L O AU - Glynn, R J AU - Levenson, M R AU - Hermos, J A AU - LoCastro, J S AU - Vokonas, P S AD - Normative Aging Study, Veterans Administration Medical Center, Bedford, Massachusetts 01730. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 25 EP - 32 VL - 53 IS - 1 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Population KW - United States KW - North America KW - Heart Diseases KW - Americas KW - Alcohol Drinking--men KW - Population Dynamics KW - Developed Countries KW - Mortality--men KW - Northern America KW - Behavior KW - Demographic Factors KW - Health--men KW - Diseases KW - Risk Factors KW - Humans KW - Middle Aged KW - Follow-Up Studies KW - Boston -- epidemiology KW - Longitudinal Studies KW - Male KW - Alcoholism -- rehabilitation KW - Coronary Disease -- mortality KW - Alcohol Drinking -- mortality KW - Alcoholism -- mortality KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72872043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Alcohol+consumption+and+mortality+in+an+American+male+population%3A+recovering+the+U-shaped+curve--findings+from+the+normative+Aging+Study.&rft.au=de+Labry%2C+L+O%3BGlynn%2C+R+J%3BLevenson%2C+M+R%3BHermos%2C+J+A%3BLoCastro%2C+J+S%3BVokonas%2C+P+S&rft.aulast=de+Labry&rft.aufirst=L&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it. AN - 72871835; 1554971 AB - Aspirin (acetylsalicylic acid) and its salicylate derivatives are effective antipyretic, analgesic, and anti-inflammatory agents that are still very widely used by the elderly despite the advent of newer, potentially safer nonsteroidal anti-inflammatory drugs (NSAIDs). However, none of the new NSAIDs have been proven to be more effective than aspirin or salicylic acid. Chronic salicylate intoxication which is most common in the elderly, may occur with therapeutic doses. Increased toxicity in older patients often appears due to inadvertent overdosage. Dual prescribing or additional use of nonprescription salicylates are some causes of unwitting long term toxicity. According to some studies, systemic clearance of salicylate (mainly by hepatic metabolism) is reduced with age, as is renal elimination. These changes are of increased importance in the elderly using high therapeutic doses of salicylates when metabolism is saturated and more unchanged drug is available for renal excretion. In the face of renal impairment, the risk of toxicity is increased. The diagnosis of acute salicylate intoxication generally does not pose diagnostic problems. Patients often present with a history of intentional overdose, with hyperventilation, fever, and nausea. The diagnosis can be confirmed by measuring serum salicylate concentrations. Chronic intoxication often poses a diagnostic dilemma with atypical presentations mimicking other disease states such as diabetic ketoacidosis, delirium, cerebrovascular accident, myocardial infarction or cardiac failure. The diagnosis of salicylate intoxication should be borne in mind when an older patient presents with recent deterioration in activities of daily living with no known cause. Plasma salicylate concentrations should be measured if salicylate intoxication is suspected, even if there is no documented history of salicylate ingestion. The risk of salicylate nephrotoxicity is also increased with age, and upper gastrointestinal haemorrhage is associated with increased mortality in older age groups. Treatment of acute toxicity consists of prompt recognition of salicylate intoxication, use of activated charcoal, correction of acid-base abnormalities, general supportive measures, and if concentrations are extremely high, dialysis can be effectively used. Chronic toxicity, which can occur even with marginally high salicylate concentrations, is treated with drug withdrawal and supportive therapy. Chronic salicylate toxicity can be averted by prescription of conservative doses of drug, avoidance of concomitant use of different salicylate preparations, and therapeutic monitoring to guide dosage. Renal function should be monitored to detect nephrotoxicity from chronic salicylate therapy. Patients should be regularly screened for evidence of gastrointestinal bleeding.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Drugs & aging AU - Durnas, C AU - Cusack, B J AD - Veterans Administration Medical Center, Boise. PY - 1992 SP - 20 EP - 34 VL - 2 IS - 1 SN - 1170-229X, 1170-229X KW - Salicylates KW - 0 KW - Index Medicus KW - Drug Interactions KW - Gastrointestinal Diseases -- diagnosis KW - Humans KW - Gastrointestinal Diseases -- chemically induced KW - Aged KW - Gastrointestinal Diseases -- prevention & control KW - Poisoning -- prevention & control KW - Salicylates -- poisoning KW - Salicylates -- pharmacokinetics KW - Salicylates -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72871835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+%26+aging&rft.atitle=Salicylate+intoxication+in+the+elderly.+Recognition+and+recommendations+on+how+to+prevent+it.&rft.au=Durnas%2C+C%3BCusack%2C+B+J&rft.aulast=Durnas&rft.aufirst=C&rft.date=1992-01-01&rft.volume=2&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Drugs+%26+aging&rft.issn=1170229X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-05 N1 - Date created - 1992-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the MMPI-PTSD subscale with PTSD and substance abuse patient populations. AN - 72867447; 1556209 AB - War-related PTSD frequently presents as a dual disorder. Questions have been raised about whether the MMPI-PTSD subscale developed by Keane, Malloy, and Fairbank (1984) is identifying a separate PTSD syndrome or is a measure of generalized distress common to various diagnostic categories, including substance abuse. In this study, veterans with PTSD with and without substance abuse were compared to veterans with substance abuse only on the MMPI-PTSD subscale (n = 22 in each of the four categories). Results support the ability of the test to distinguish between groups of veterans with PTSD and those with substance abuse only. The findings lend indirect support to the validity of a distinct PTSD symptom cluster. JF - Journal of clinical psychology AU - Kenderdine, S K AU - Phillips, E J AU - Scurfield, R M AD - Veterans Administration Medical Center, Tacoma, Washington. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 136 EP - 139 VL - 48 IS - 1 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Humans KW - Follow-Up Studies KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Combat Disorders -- psychology KW - Hospitalization KW - Alcoholism -- diagnosis KW - MMPI -- statistics & numerical data KW - Combat Disorders -- diagnosis KW - Combat Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72867447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Comparison+of+the+MMPI-PTSD+subscale+with+PTSD+and+substance+abuse+patient+populations.&rft.au=Kenderdine%2C+S+K%3BPhillips%2C+E+J%3BScurfield%2C+R+M&rft.aulast=Kenderdine&rft.aufirst=S&rft.date=1992-01-01&rft.volume=48&rft.issue=1&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-01 N1 - Date created - 1992-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat. AN - 72840881; 1542888 AB - Chronic lead exposure may cause hypertension in normotensive rats. This hypertensinogenic effect has been attributed to perturbations in the renin-angiotensin axis, the contractile response of the vascular smooth muscle, or the intracellular Ca2+ homeostasis as a consequence of the inhibition of Na(+)-K(+)-ATPase activity. In this study we examined the short-term effect of lead exposure on blood pressure, plasma renin activity, vascular contractility, and renal Na(+)-K(+)-ATPase activity and abundance in the spontaneously hypertensive rat. Our data indicate that modest lead exposure caused blood pressure elevation within two weeks in this rat strain that is genetically susceptible to the development of hypertension. This rapid blood pressure-elevating effect did not appear to depend on the mechanisms described in hypertension associated with more chronic lead exposure listed above. This acute model provides an additional approach to the study of lead-induced hypertension. JF - Toxicology and industrial health AU - Nakhoul, F AU - Kayne, L H AU - Brautbar, N AU - Hu, M S AU - McDonough, A AU - Eggena, P AU - Golub, M S AU - Berger, M AU - Chang, C T AU - Jamgotchian, N AD - Veterans Administration Medical Center, Sepulveda, California. PY - 1992 SP - 89 EP - 102 VL - 8 IS - 1-2 SN - 0748-2337, 0748-2337 KW - Lead KW - 2P299V784P KW - Renin KW - EC 3.4.23.15 KW - Index Medicus KW - Rats KW - Body Weight KW - Animals KW - Renin -- metabolism KW - Rats, Inbred SHR KW - Femoral Artery -- physiology KW - Male KW - Lead -- urine KW - Hypertension -- chemically induced KW - Lead -- toxicity KW - Environmental Exposure KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72840881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Rapid+hypertensinogenic+effect+of+lead%3A+studies+in+the+spontaneously+hypertensive+rat.&rft.au=Nakhoul%2C+F%3BKayne%2C+L+H%3BBrautbar%2C+N%3BHu%2C+M+S%3BMcDonough%2C+A%3BEggena%2C+P%3BGolub%2C+M+S%3BBerger%2C+M%3BChang%2C+C+T%3BJamgotchian%2C+N&rft.aulast=Nakhoul&rft.aufirst=F&rft.date=1992-01-01&rft.volume=8&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-07 N1 - Date created - 1992-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Electrophysiological effects of phencyclidine and the sigma agonist ditolylguanidine in the cerebellum of the rat. AN - 72830642; 1311809 AB - The electrophysiological actions of phencyclidine (PCP) and the sigma agonist 1,3-di(2tolyl)guanidine (DTG) were examined in the cerebellum of urethane-anesthetized rats. The object of the study was to determine if PCP and sigma agonists shared a common mechanism of action. The cerebellar Purkinje neuron was chosen because it has sigma receptors but not N-methyl-D-aspartate receptors, where PCP has additional effects. Both DTG and PCP decreased the spontaneous discharge rate of cerebellar Purkinje neurons after parenteral administration. When the drugs were applied locally to single Purkinje neurons, using pressure ejection through multibarrel micropipettes, both compounds decreased the spontaneous activity of the neurons with equal potency. Previous studies have shown that the actions of PCP in the cerebellum are dependent upon an interaction with noradrenergic terminals from the nucleus locus coeruleus. A similar finding was made in this study for DTG. Elimination of the noradrenergic input by lesion with the neurotoxin, 6-hydroxydopamine, diminished equally the effects of PCP and DTG. Treatment of the animals with haloperidol had similar effects. It is concluded that PCP and the sigma agonist DTG both act as indirect noradrenergic agonists in the cerebellum. JF - Neuropharmacology AU - Kim, M AU - Bickford, P C AD - Denver Veterans Administration Medical Center, CO 80776. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 77 EP - 83 VL - 31 IS - 1 SN - 0028-3908, 0028-3908 KW - Guanidines KW - 0 KW - Oxidopamine KW - 8HW4YBZ748 KW - Phencyclidine KW - J1DOI7UV76 KW - Haloperidol KW - J6292F8L3D KW - 1,3-ditolylguanidine KW - LL2P01I17O KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Purkinje Fibers -- drug effects KW - Norepinephrine -- physiology KW - Animals KW - Synaptic Transmission -- drug effects KW - Haloperidol -- pharmacology KW - Electrophysiology KW - Male KW - Oxidopamine -- pharmacology KW - Cerebellum -- drug effects KW - Phencyclidine -- pharmacology KW - Guanidines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72830642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Electrophysiological+effects+of+phencyclidine+and+the+sigma+agonist+ditolylguanidine+in+the+cerebellum+of+the+rat.&rft.au=Kim%2C+M%3BBickford%2C+P+C&rft.aulast=Kim&rft.aufirst=M&rft.date=1992-01-01&rft.volume=31&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-08 N1 - Date created - 1992-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trophic regulation of acetylcholinesterase isoenzymes in adult mammalian skeletal muscles. AN - 72820393; 1311432 AB - This work addresses the physiological regulation of skeletal muscle acetylcholinesterase (AChE) isoforms by examining endplate-enriched samples from adult rat gracilis muscles 48 h after: low-intensity treadmill exercise; obturator nerve transection; nerve impulse conduction blockade by tetrodotoxin; acetylcholine (ACh) receptor (AChR) inactivation by alpha-bungarotoxin; and, addition of obturator nerve extracts to muscles in organ culture. Results document the important role(s) of functional AChRs and ACh-AChR interactions in the differential control of individual AChE isoenzymes. A theoretical model based on these and other findings considers that: AChR activation by spontaneously released ACh is the only neural factor required for the maintenance of G1 + G2 AChE; the amount of A12 AChE is determined by the combined effects of ACh and another neurogenic substance; although mechanisms intrinsic to myofibers control normal levels of G4 AChE, enhanced production of this isoform is initiated through increasing the frequency of ACh-AChR interactions. JF - Neurochemical research AU - Fernandez, H L AU - Hodges-Savola, C A AD - Neuroscience Research Laboratory, U.S. Department of Veterans Affairs Medical Center, Kansas City, Missouri 64128. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 115 EP - 124 VL - 17 IS - 1 SN - 0364-3190, 0364-3190 KW - Bungarotoxins KW - 0 KW - Cholinergic Antagonists KW - Isoenzymes KW - Receptors, Cholinergic KW - Tetrodotoxin KW - 4368-28-9 KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Index Medicus KW - Space life sciences KW - Animals KW - Motor Activity -- physiology KW - Motor Endplate -- enzymology KW - Obturator Nerve -- surgery KW - Bungarotoxins -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Physical Exertion KW - Receptors, Cholinergic -- physiology KW - Obturator Nerve -- physiology KW - Tetrodotoxin -- pharmacology KW - Organ Culture Techniques KW - Synaptic Transmission KW - Acetylcholinesterase -- metabolism KW - Muscles -- enzymology KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72820393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Trophic+regulation+of+acetylcholinesterase+isoenzymes+in+adult+mammalian+skeletal+muscles.&rft.au=Fernandez%2C+H+L%3BHodges-Savola%2C+C+A&rft.aulast=Fernandez&rft.aufirst=H&rft.date=1992-01-01&rft.volume=17&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-02 N1 - Date created - 1992-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ribosomal RNA activity and protein in skeletal muscles of chronic ethanol-fed rats. AN - 72789708; 1733428 AB - The effect of prolonged ethanol exposure on ribosomal RNA activity and the content of RNA and protein in skeletal muscles of 15- and 22-25-month-old rats was evaluated. Experimental rats were fed a liquid diet containing 6.7% ethanol for 2, 4 and 6 months, and control rats were pair-fed an isocaloric diet. The in vivo incorporation of [3H]puromycin into nascent peptides on messenger RNA-ribosome complexes was determined to assess muscle ribosomal RNA activity. This activity was significantly reduced in extensor digitorum longus and soleus muscles of rats fed ethanol for 2 months. While the total RNA content of these muscles was unchanged after feeding ethanol for 2, 4 and 6 months, their messenger RNA content was decreased from 26-34%. The total protein content was reduced after ethanol was consumed for 6 months. Taken together, the results suggest that alterations in the transcriptional or posttranscriptional control of messenger RNA may contribute toward the development of alcoholic myopathy after prolonged ethanol consumption. JF - Alcohol (Fayetteville, N.Y.) AU - Held, I R AD - Neuroscience Research Laboratory, Veterans Administration Hospital, Hines, IL 60141. PY - 1992 SP - 79 EP - 82 VL - 9 IS - 1 SN - 0741-8329, 0741-8329 KW - Muscle Proteins KW - 0 KW - RNA, Messenger KW - RNA, Ribosomal KW - Ethanol KW - 3K9958V90M KW - Puromycin KW - 4A6ZS6Q2CL KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - RNA, Messenger -- metabolism KW - Puromycin -- metabolism KW - Male KW - Muscle Proteins -- metabolism KW - RNA, Ribosomal -- metabolism KW - Ethanol -- pharmacology KW - Muscles -- metabolism KW - Ethanol -- administration & dosage KW - Alcoholism -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Ribosomal+RNA+activity+and+protein+in+skeletal+muscles+of+chronic+ethanol-fed+rats.&rft.au=Held%2C+I+R&rft.aulast=Held&rft.aufirst=I&rft.date=1992-01-01&rft.volume=9&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-03 N1 - Date created - 1992-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Erythromycin ototoxicity: prospective assessment with serum concentrations and audiograms in a study of patients with pneumonia. AN - 72777991; 1731511 AB - The incidence and risk factors for erythromycin-induced ototoxicity are unknown. We conducted a prospective, nested case-control study of assessment of auditory function in patients receiving erythromycin versus other antibiotics (control group) for community-acquired pneumonia. Sequential audiograms were performed during antibiotic therapy for both cases and controls by an audiologist unaware of the identity of the therapy administered. Erythromycin serum concentrations were obtained for all patients receiving erythromycin. Symptomatic ototoxicity (tinnitus or hearing loss) confirmed by audiograms was documented in five of 30 patients receiving erythromycin and none of 15 receiving other antibiotics. Ototoxicity was significantly related to high peak concentration and high AUC 0-infinity as a function of decreased total systemic clearance. Ototoxicity occurred only in those patients who received 4 g/day versus 2 g/day or no erythromycin (p = 0.05). Ototoxicity resolved in all patients within 6 to 14 days after discontinuation of therapy. Erythromycin ototoxicity is dose- and serum concentration-dependent. Patients receiving erythromycin, especially at a total daily dose of 4 g, should be monitored regularly for subjective evidence of sensorineural hearing dysfunction. Ototoxicity is reversible if the diagnosis is made early in the course. JF - The American journal of medicine AU - Swanson, D J AU - Sung, R J AU - Fine, M J AU - Orloff, J J AU - Chu, S Y AU - Yu, V L AD - Department of Pharmacy Practice, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 61 EP - 68 VL - 92 IS - 1 SN - 0002-9343, 0002-9343 KW - Erythromycin KW - 63937KV33D KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Hearing Loss, Sensorineural -- chemically induced KW - Audiometry KW - Humans KW - Adult KW - Hearing Loss, Bilateral -- chemically induced KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Tinnitus -- chemically induced KW - Pneumonia -- blood KW - Erythromycin -- adverse effects KW - Hearing Disorders -- blood KW - Hearing Disorders -- chemically induced KW - Pneumonia -- drug therapy KW - Erythromycin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72777991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Erythromycin+ototoxicity%3A+prospective+assessment+with+serum+concentrations+and+audiograms+in+a+study+of+patients+with+pneumonia.&rft.au=Swanson%2C+D+J%3BSung%2C+R+J%3BFine%2C+M+J%3BOrloff%2C+J+J%3BChu%2C+S+Y%3BYu%2C+V+L&rft.aulast=Swanson&rft.aufirst=D&rft.date=1992-01-01&rft.volume=92&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Med. 1993 Feb;94(2):227-9 [8430720] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects. AN - 72775508; 1731046 AB - Studies were conducted to investigate the clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects. Each of 20 male patients stabilized on 24 mg of methadone daily received two i.v. pharmacological challenges: one with naloxone (0.05, 0.10, 0.15 and 0.20 mg; five patients each dose), and one with saline placebo. Measures of opioid withdrawal, affective state, cognitive performance and changes in autonomic parameters were assessed after each pharmacological challenge. Naloxone produced dose-dependent increases in opiate withdrawal scale scores and in symptoms of dysphoria as measured by the Profile of Mood States. Differences within subjects between naloxone and placebo infusions in Profile of Mood States scores were highly correlated with differences in opioid withdrawal as assessed by both subjective and objective rating scales. Naloxone also produced substantial increases in pulse, systolic and diastolic blood pressure and respiratory rate, as well as a small decrease in temperature. However, naloxone-induced changes from base-line values in these autonomic parameters correlated only modestly with other measures of opioid withdrawal. No differences between infusions were observed in two measures of cognitive performance (Stroop Color and Word Test, Digit Span Test). The results indicate that dysphoric mood states reflecting a broad range of affective experience must be considered as integral components of the naloxone-precipitated opioid withdrawal syndrome. JF - The Journal of pharmacology and experimental therapeutics AU - Kanof, P D AU - Handelsman, L AU - Aronson, M J AU - Ness, R AU - Cochrane, K J AU - Rubinstein, K J AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, NY. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 355 EP - 363 VL - 260 IS - 1 SN - 0022-3565, 0022-3565 KW - Narcotics KW - 0 KW - Naloxone KW - 36B82AMQ7N KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Infusions, Intravenous KW - Cognition -- drug effects KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Respiration -- drug effects KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Substance Withdrawal Syndrome -- physiopathology KW - Naloxone -- therapeutic use KW - Substance Withdrawal Syndrome -- drug therapy KW - Narcotics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72775508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Clinical+characteristics+of+naloxone-precipitated+withdrawal+in+human+opioid-dependent+subjects.&rft.au=Kanof%2C+P+D%3BHandelsman%2C+L%3BAronson%2C+M+J%3BNess%2C+R%3BCochrane%2C+K+J%3BRubinstein%2C+K+J&rft.aulast=Kanof&rft.aufirst=P&rft.date=1992-01-01&rft.volume=260&rft.issue=1&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy. AN - 72755237; 1727388 AB - The purpose of this study was to investigate whether substrate deprivation acutely and selectively decreases ATP concentration in an experimental sarcoma. Two methods of substrate deprivation were examined: glycolysis was inhibited using 2-deoxyglucose (2DG), and plasma substrate levels were reduced using insulin. The effects of treatment on tumor ATP, inorganic phosphate, and pH were studied by 31P nuclear magnetic resonance spectroscopy. 2DG (2 g/kg) was administered i.p. to rats bearing s.c. methylcholanthrene-induced sarcomas. Inhibition of glycolysis by 2DG caused a 52 +/- 13% (SE) decrease in the tumor ATP to inorganic phosphate ratio, associated with a decrease in pH of 0.38 +/- 0.10 unit. The same dose of 2DG caused no significant change in the ratio of phosphocreatine to ATP in brain. Insulin (125 units/kg, i.p.) caused a 68% decline in plasma glucose and a 71% decline in betahydroxybutyrate compared to saline-treated animals. Concomitantly, 31P nuclear magnetic resonance spectroscopy detected a 48 +/- 13% decrease in sarcoma ATP, with a reciprocal elevation of inorganic phosphate in insulin-treated animals. In contrast, the brain phosphocratine/ATP ratio was unaffected by insulin. These results suggest that large tumors are acutely sensitive to inhibition of glycolysis and reductions in plasma levels of substrates for oxidative phosphorylation and glycolysis, while the brain is unaffected. In addition, this work provides support for the use of 31P nuclear magnetic resonance spectroscopy to monitor tumor response to therapy. JF - Cancer research AU - Karczmar, G S AU - Arbeit, J M AU - Toy, B J AU - Speder, A AU - Weiner, M W AD - Magnetic Resonance Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 71 EP - 76 VL - 52 IS - 1 SN - 0008-5472, 0008-5472 KW - Insulin KW - 0 KW - Phosphorus KW - 27YLU75U4W KW - Methylcholanthrene KW - 56-49-5 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Brain -- metabolism KW - Male KW - Magnetic Resonance Spectroscopy KW - Sarcoma, Experimental -- chemically induced KW - Sarcoma, Experimental -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Insulin -- pharmacology KW - Deoxyglucose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72755237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Selective+depletion+of+tumor+ATP+by+2-deoxyglucose+and+insulin%2C+detected+by+31P+magnetic+resonance+spectroscopy.&rft.au=Karczmar%2C+G+S%3BArbeit%2C+J+M%3BToy%2C+B+J%3BSpeder%2C+A%3BWeiner%2C+M+W&rft.aulast=Karczmar&rft.aufirst=G&rft.date=1992-01-01&rft.volume=52&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-17 N1 - Date created - 1992-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potentiation of acute acetaminophen lethality by selenium and vitamin E deficiency in mice. AN - 72733558; 1729474 AB - The effects of selenium, vitamin E, and DL-methionine deficiency on the acute lethality and hepatotoxicity of acetaminophen in male CD-1 mice were studied. Vitamin E and selenium deficiencies led to an increase in the acute lethality of acetaminophen, with a decrease in the LD50 from 376 to 84 mg/kg. These dietary deficiencies impaired the inducibility of the hepatic microsomal mixed function oxidase system by phenobarbital, but on the basis of the covalent binding of acetaminophen to microsomes, these treatments did not alter the activation of acetaminophen to a reactive intermediate by this system. Addition of methionine to the deficient diet restored hepatic glutathione content to control levels but did little to protect against the acute lethality of acetaminophen. In methionine-supplemented animals, the addition of either selenium or vitamin E increased the LD50 of acetaminophen to 167 and 200 mg/kg, respectively. Administration of a sublethal, toxic dose of acetaminophen (LD30) to the methionine-supplemented and selenium- and vitamin E-deficient mice did not produce any hepatic damage as evidenced by a lack of plasma aminotransferase elevation. In view of the known antioxidant effects of vitamin E and selenium, these data suggest the involvement of a reactive radical in the acute lethality of acetaminophen and further suggest that death from acute acetaminophen overdose in chronic selenium- and vitamin E-deficient mice may be unrelated to liver necrosis. JF - The Journal of nutrition AU - Peterson, F J AU - Lindemann, N J AU - Duquette, P H AU - Holtzman, J L AD - Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 74 EP - 81 VL - 122 IS - 1 SN - 0022-3166, 0022-3166 KW - Acetaminophen KW - 362O9ITL9D KW - Methionine KW - AE28F7PNPL KW - Mixed Function Oxygenases KW - EC 1.- KW - Selenium KW - H6241UJ22B KW - Index Medicus KW - Body Weight KW - Animals KW - Mixed Function Oxygenases -- metabolism KW - Methionine -- deficiency KW - Lethal Dose 50 KW - Mice KW - Drug Synergism KW - Male KW - Selenium -- deficiency KW - Liver -- enzymology KW - Liver -- drug effects KW - Vitamin E Deficiency -- metabolism KW - Liver -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72733558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Potentiation+of+acute+acetaminophen+lethality+by+selenium+and+vitamin+E+deficiency+in+mice.&rft.au=Peterson%2C+F+J%3BLindemann%2C+N+J%3BDuquette%2C+P+H%3BHoltzman%2C+J+L&rft.aulast=Peterson&rft.aufirst=F&rft.date=1992-01-01&rft.volume=122&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-11 N1 - Date created - 1992-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outcome Study: Comparison of Short-Term vs Long-Term Treatment in a Residential Community AN - 61597520; 199200393 AB - To compare the effectiveness of long- vs short-term treatment for drug addicts, a study was conducted of 38 male patients admitted to a 3-month residential treatment center (RTC) at the Veterans Administration Medical Center in West Los Angeles, Calif, in 1985, who were surveyed 6 months after discharge. Results are compared to a similar study conducted in 1973 at the same location, with a 1-year length of stay. The comparison reveals differences in age, race, marital status, & drugs of abuse. Results show that the 12-month program had a 26% failure rate, compared to the 1985 failure rate of 47%. It is concluded that the longer program appears to be nearly twice as effective as the 3-month program. 4 Tables, 1 Figure, 11 References. S. Dilts JF - The International Journal of the Addictions AU - Charuvastra, V Charles AU - Dalali, Isobel Day AU - Cassuci, Michael AU - Ling, Walter AD - Veterans Administration Medical Center, 11301 Wilshire Blvd Los Angeles CA 90073 Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 15 EP - 23 VL - 27 IS - 1 SN - 0020-773X, 0020-773X KW - long- vs short-term residential drug treatment programs, male patients KW - 1973/1985 medical records/survey data KW - Veterans Administration Medical Center, West Los Angeles, California KW - Treatment Outcomes KW - Drug Addiction KW - Treatment Programs KW - Males KW - Residential Institutions KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61597520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+the+Addictions&rft.atitle=Outcome+Study%3A+Comparison+of+Short-Term+vs+Long-Term+Treatment+in+a+Residential+Community&rft.au=Charuvastra%2C+V+Charles%3BDalali%2C+Isobel+Day%3BCassuci%2C+Michael%3BLing%2C+Walter&rft.aulast=Charuvastra&rft.aufirst=V&rft.date=1992-01-01&rft.volume=27&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+the+Addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Drug Addiction; Treatment Programs; Treatment Outcomes; Residential Institutions; Males ER - TY - JOUR T1 - Social Resource Characteristics and Adolescent Substance Abuse Relapse AN - 61312107; 9306754 AB - Examines social resource networks of adolescent substance abusers to determine whether the abuse, perceived similarity, or perceived support of individuals in those networks are associated with relapse rates. Surveys completed by 20 teens in residential treatment in San Diego (Calif) County & a resource person (usually a parent) investigated history & current functioning. Individual diagnostic & social network interviews were administered, with follow-up interviews occurring 3 months after hospital discharge. It was found that perceived similarity to one's social network was critical to the degree of influence that network had on either relapse or continued abstinence. Relapse was most common in Ss who perceived themselves as similar to a network comprised of other abusers. 2 Tables, 3 Figures, 33 References. Adapted from the source document. JF - Journal of Adolescent Chemical Dependency AU - Vik, Peter W AU - Grizzle, Kenneth L AU - Brown, Sandra A AD - c/o Brown -- Psychology Service Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 59 EP - 74 VL - 2 IS - 2 SN - 0896-7768, 0896-7768 KW - social resource networks-relapse rate relationship, adolescent substance abusers KW - survey/other data KW - San Diego County, California KW - Substance Abuse KW - Social Networks KW - Recidivism KW - Adolescents KW - Resources KW - article KW - 1939: the family and socialization; adolescence & youth KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61312107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Chemical+Dependency&rft.atitle=Social+Resource+Characteristics+and+Adolescent+Substance+Abuse+Relapse&rft.au=Vik%2C+Peter+W%3BGrizzle%2C+Kenneth+L%3BBrown%2C+Sandra+A&rft.aulast=Vik&rft.aufirst=Peter&rft.date=1992-01-01&rft.volume=2&rft.issue=2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Chemical+Dependency&rft.issn=08967768&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JACDEM N1 - SubjectsTermNotLitGenreText - Substance Abuse; Adolescents; Resources; Social Networks; Recidivism ER - TY - JOUR T1 - A Retrospective Evaluation of Factors Influencing Successful Outcomes on an Inpatient Psychiatric Crisis Unit AN - 1761715852; 199200073 AB - A retrospective review of the hospital records of 69 patients on a short-term crisis intervention unit was conducted to differentiate the characteristics of the 41 patients who were successfully discharged to the community vs the 28 who required placement in a long-term care unit. Results indicate that treatment compliance & family support were significant factors associated with successful program completion. 2 Tables, 6 References. Adapted from the source document. JF - Research on Social Work Practice AU - Anthony, Dominic J, Jr AD - Social Work Dept West Haven Veterans Administration Medical Center, 950 Campbell Ave CT 06516 Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 56 EP - 64 VL - 2 IS - 1 SN - 1049-7315, 1049-7315 KW - short-term psychiatric crisis intervention unit's success, hospital, patient characteristics KW - retrospective record review KW - Crisis Intervention KW - Treatment Outcomes KW - Mental Patients KW - Client Characteristics KW - Treatment Compliance KW - Mental Hospitals KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761715852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+on+Social+Work+Practice&rft.atitle=A+Retrospective+Evaluation+of+Factors+Influencing+Successful+Outcomes+on+an+Inpatient+Psychiatric+Crisis+Unit&rft.au=Anthony%2C+Dominic+J%2C+Jr&rft.aulast=Anthony&rft.aufirst=Dominic&rft.date=1992-01-01&rft.volume=2&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Research+on+Social+Work+Practice&rft.issn=10497315&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Patients; Client Characteristics; Mental Hospitals; Crisis Intervention; Treatment Compliance; Treatment Outcomes ER - TY - JOUR T1 - Data Collection: Are Social Workers Reliable? AN - 1761713012; 199301829 AB - Personal information about social services clients & their families that may be unrelated to direct clinical work is nonetheless needed for purposes of payment, service documentation, agency planning, & accountability. The worker's concern about the appropriateness of collecting this data may result in poor compliance or even falsification of information. Questionnaire data from 244 social workers show that noncompliance with data collection requirements was substantial. There was also a significant degree of conflict about privacy & confidentiality issues. These findings suggest a basis of concern for those who must rely on accurate data for administrative planning. 3 Figures, 7 References. Adapted from the source document. JF - Administration in Social Work AU - O'Brien, Nancy AU - McClellan, Thomas AU - Alfs, Diane AD - Dept Social Work Veterans Administration Medical Center, 1 Veterans Dr Minneapolis MN 55417 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 89 EP - 99 VL - 16 IS - 2 SN - 0364-3107, 0364-3107 KW - social services clients, social workers' data collection requirement noncompliance KW - questionnaire data KW - Minnesota KW - Client Relations KW - Client Characteristics KW - Social Workers KW - Compliance KW - Data Collection KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761713012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Social+Work&rft.atitle=Data+Collection%3A+Are+Social+Workers+Reliable%3F&rft.au=O%27Brien%2C+Nancy%3BMcClellan%2C+Thomas%3BAlfs%2C+Diane&rft.aulast=O%27Brien&rft.aufirst=Nancy&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Administration+in+Social+Work&rft.issn=03643107&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Minnesota; Social Workers; Client Relations; Client Characteristics; Data Collection; Compliance ER - TY - JOUR T1 - Assessing Health Care Delivery to Male versus Female Veterans AN - 1761712144; 199202478 AB - To explore allegations that female (F) veterans have not received the same quality of care as male (M) veterans in US Dept of Veterans Affairs (VA) hospitals, a chart review of 48 M & 66 F inpatients, & telephone interviews with 55 veterans treated at a large metropolitan VA hospital Nov 1988-Apr 1989 were conducted. Chart documentation was poor, regardless of gender. On average, 67% of Ms & Fs received regular gender-specific examinations, although the number was somewhat lower for Fs. Both women & men were quite satisfied with the care received. Future studies should focus on the evaluation of workable solutions to providing equitable health care to women veterans. 3 Tables, 16 References. Adapted from the source document. JF - Women and Health AU - Turpin, Robin S AU - Darcy, Laurie A AU - Weaver, Frances M AU - Kruse, Katharine AD - Health Services Research & Development Field Program Veterans Administration Hospital, Hines IL 60141 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 81 EP - 95 VL - 18 IS - 1 SN - 0363-0242, 0363-0242 KW - health care quality assessment, male vs female veterans KW - 1988/89 interviews/chart reviews KW - US Veterans Administration hospital patients KW - Veterans KW - Sexual Inequality KW - Health Care KW - Government Agencies KW - Sex Differences KW - United States of America KW - Hospitals KW - article KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761712144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+and+Health&rft.atitle=Assessing+Health+Care+Delivery+to+Male+versus+Female+Veterans&rft.au=Turpin%2C+Robin+S%3BDarcy%2C+Laurie+A%3BWeaver%2C+Frances+M%3BKruse%2C+Katharine&rft.aulast=Turpin&rft.aufirst=Robin&rft.date=1992-01-01&rft.volume=18&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Women+and+Health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care; Sex Differences; United States of America; Veterans; Government Agencies; Hospitals; Sexual Inequality ER - TY - JOUR T1 - Attitudes toward Mandatory Human Immunodeficiency Virus Testing and Contact Tracing: A Survey of Intravenous Drug Users in Treatment AN - 1761710422; 199200540 AB - Interview & self-report questionnaire data are used to investigate attitudes toward mandatory human immunodeficiency virus (HIV) testing & contact tracing among 196 methadone-maintained patients from 2 Philadelphia (Pa) clinics. Findings indicate that although most methadone patients supported mandatory testing, their support was influenced by past testing experience; ie, significantly more untested than tested individuals were opposed to the policy. Regarding contact tracing, results indicate that most patients with seronegative results supported tracing, but of the 3 patients with seropositive results surveyed, 2 were opposed to it. However, most seropositive & seronegative patients reported a willingness to comply with tracing if it were to become law. 11 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - DePhilippis, Dominick AU - Metzger, David S AU - Woody, George E AU - Navaline, Helen A AD - Philadelphia Veterans Administration Medical Center, University & Woodland Aves PA 19104 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 39 EP - 42 VL - 9 IS - 1 SN - 0740-5472, 0740-5472 KW - human immunodeficiency virus, testing/contact tracing, methadone patients' attitudes KW - interview/questionnaire data KW - Philadelphia, Pennsylvania KW - Attitudes KW - Tests KW - Acquired Immune Deficiency Syndrome KW - Patients KW - Public Policy KW - Methadone Maintenance KW - article KW - 6123: self-help support groups/networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761710422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Attitudes+toward+Mandatory+Human+Immunodeficiency+Virus+Testing+and+Contact+Tracing%3A+A+Survey+of+Intravenous+Drug+Users+in+Treatment&rft.au=DePhilippis%2C+Dominick%3BMetzger%2C+David+S%3BWoody%2C+George+E%3BNavaline%2C+Helen+A&rft.aulast=DePhilippis&rft.aufirst=Dominick&rft.date=1992-01-01&rft.volume=9&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Philadelphia, Pennsylvania; Public Policy; Acquired Immune Deficiency Syndrome; Tests; Methadone Maintenance; Patients; Attitudes ER - TY - JOUR T1 - Alcoholism in older persons: A review of the literature AN - 16682808; 3052400 AB - Alcohol abuse and dependence in elderly persons is of growing social concern. The most consistent findings of cross-sectional and longitudinal studies are that the quantity and frequency of alcohol consumption is higher in elderly men than in elderly women, as is the prevalence of alcohol-related problems. Most studies show a decrease with age in consumption and alcohol-related problems among heavy drinkers. Longitudinal studies show no changes in consumption among light drinkers. Elderly persons with lower incomes consume less alcohol than those with higher incomes. Hospitalized and outpatient populations have more problem drinkers, and the elderly alcoholic is at greater risk for medical and psychiatric comorbidity. About one-third to one-half of elderly alcoholics experience the onset of problem drinking in middle or late life. Outcomes seem to be better for those who have late-onset drinking and may be improved for those treated in same-age rather than mixed-age groups. JF - HOSP. COMMUNITY PSYCHIATRY AU - Liberto, J G AU - Oslin, D W AU - Ruskin, P E AD - Spec. Popul. Geriatr. Subst. Abuse Program, Veterans Administration Med. Cent., 3900 Loch Raven Blvd., Baltimore, MD 21218, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 975 EP - 984 VL - 43 IS - 10 SN - 0022-1597, 0022-1597 KW - gerontology KW - substance abuse KW - alcoholism KW - Risk Abstracts KW - socioeconomics KW - gender KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16682808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HOSP.+COMMUNITY+PSYCHIATRY&rft.atitle=Alcoholism+in+older+persons%3A+A+review+of+the+literature&rft.au=Liberto%2C+J+G%3BOslin%2C+D+W%3BRuskin%2C+P+E&rft.aulast=Liberto&rft.aufirst=J&rft.date=1992-01-01&rft.volume=43&rft.issue=10&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=HOSP.+COMMUNITY+PSYCHIATRY&rft.issn=00221597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - gender; socioeconomics ER - TY - JOUR T1 - High-performance liquid chromatography of bile acids effect of hydroxyl groups at C-3, 6, 7 and 12 on bile acid mobility. AN - 16503711; 42965 AB - The high-performance liquid chromatographic characteristics of a number of bile acids with hydroxyl groups at C-3, 6, 7 and 12 positions are reported. Using Nova-pak C sub(18) reversed-phased columns and mobile phase consisting of acetonitrile/water/methanol/acetic acid mixtures, it was found that compounds with beta -hydroxyl groups were eluted much earlier than those with alpha -hydroxyl groups. Introduction of a hydroxyl group caused a marked increase in polarity of the bile acid, however, the effect was not well defined in bile acids with vicinal glycol system at C-6,7. The retention volumes of the various bile acids were reproducible and can be useful for characterization of bile acids in biological fluids. JF - Journal of Liquid Chromatography AU - Batta, Ashok K AU - Aggarwal, Suresht K AU - Salen, Gerald AD - Veterans Administration Medical Cent, East Orange, NJ, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 467 EP - 478 VL - 15 IS - 3 SN - 0148-3919, 0148-3919 KW - Acetic acid KW - Acetonitrile KW - Bile acids KW - Biological materials KW - Chenodeoxycholic acid KW - Cholic acid KW - Deoxycholic acid KW - High performance liquid chromatography KW - Hyocholic acid KW - Hyodeoxycholic acid KW - Lithocholic acid KW - Methanol KW - Ursodeoxycholic acid KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Water KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 804.1:ORGANIC COMPOUNDS KW - W 30965:Miscellaneous, Reviews KW - W4 801.1:CHEMISTRY (GENERAL) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16503711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liquid+Chromatography&rft.atitle=High-performance+liquid+chromatography+of+bile+acids+effect+of+hydroxyl+groups+at+C-3%2C+6%2C+7+and+12+on+bile+acid+mobility.&rft.au=Batta%2C+Ashok+K%3BAggarwal%2C+Suresht+K%3BSalen%2C+Gerald&rft.aulast=Batta&rft.aufirst=Ashok&rft.date=1992-01-01&rft.volume=15&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liquid+Chromatography&rft.issn=01483919&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Water ER - TY - JOUR T1 - Stimulus timing device for capturing fast physiologic events by quick-freezing. AN - 16467082; 32395 AB - A timing device was designed that, in conjunction with an impact type of quick-freezing apparatus and an externally-triggerable stimulus generator, allows the application of an electrical stimulus to a muscle preparation at a selected time interval before quick-freezing and the measurement of the interval with submillisecond precision. This is needed for stopping fast physiological events in calcium release and excitation-contraction coupling and allows studying the morphological parameters (by freeze-fracture and freeze-substitution) and elemental distributions (by x-ray microanalysis) as a function of time after stimulation. The device should be adaptable for use with most equipment designed for quick-freezing electrically excitable tissue by impact on a cold solid surface. JF - Scanning Microscopy AU - Nassar, R AU - Sommer, J R AD - Duke Univ and Veterans Administration Medical Cent, Durham, NC, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 745 EP - 751 VL - 6 IS - 3 SN - 0891-7035, 0891-7035 KW - Biology KW - Cryogenics KW - Freeze fracture KW - Freeze substitution KW - Freezing KW - In vivo structure KW - Microanalysis KW - Microscopic examination KW - Morphology KW - Muscle KW - Physiological agents KW - Quick freezing KW - Timing devices KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Mechanical Engineering Abstracts (ISMEC) KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 741.1:LIGHT/OPTICS KW - W4 461.9:BIOLOGY KW - W4 644.4:CRYOGENICS KW - W 30965:Miscellaneous, Reviews KW - W4 801.1:CHEMISTRY (GENERAL) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16467082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Stimulus+timing+device+for+capturing+fast+physiologic+events+by+quick-freezing.&rft.au=Nassar%2C+R%3BSommer%2C+J+R&rft.aulast=Nassar&rft.aufirst=R&rft.date=1992-01-01&rft.volume=6&rft.issue=3&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Morphology; Freezing; Cryogenics; Biology ER - TY - JOUR T1 - Mineral fiber content of lung tissue in patients with environmental exposures: household contacts vs. building occupants. AN - 72707809; 1809164 AB - Analysis of tissue mineral fiber content in patients with environmental exposures has seldom been reported in the past. Our studies of six household contacts of asbestos workers indicate that these individuals often have pulmonary asbestos concentrations similar to some occupationally exposed individuals. In contrast, our studies of four occupants of buildings with asbestos-containing materials indicate that these individuals often have pulmonary asbestos burdens indistinguishable from the general nonoccupationally exposed population. However, one such building occupant exposed for many years and who later developed pleural mesothelioma was studied in detail, and it was concluded that her exposure as a teacher's aide in a school building containing acoustical plaster was the likely cause of her mesothelioma. JF - Annals of the New York Academy of Sciences AU - Roggli, V L AU - Longo, W E AD - Department of Pathology, Durham Veterans Administration, North Carolina. Y1 - 1991/12/31/ PY - 1991 DA - 1991 Dec 31 SP - 511 EP - 518 VL - 643 SN - 0077-8923, 0077-8923 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Adult KW - Environmental Exposure KW - Family KW - Aged KW - Middle Aged KW - Male KW - Female KW - Air Pollution, Indoor -- adverse effects KW - Peritoneal Neoplasms -- etiology KW - Mesothelioma -- etiology KW - Pleural Neoplasms -- pathology KW - Peritoneal Neoplasms -- pathology KW - Mesothelioma -- pathology KW - Asbestos -- adverse effects KW - Pleural Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72707809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Mineral+fiber+content+of+lung+tissue+in+patients+with+environmental+exposures%3A+household+contacts+vs.+building+occupants.&rft.au=Roggli%2C+V+L%3BLongo%2C+W+E&rft.aulast=Roggli&rft.aufirst=V&rft.date=1991-12-31&rft.volume=643&rft.issue=&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-15 N1 - Date created - 1992-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis. AN - 72517497; 1744103 AB - We have recently shown that the immediately submembranous domain of the human insulin receptor (hIR) is required for rapid ligand-dependent internalization (Thies, R. S., Webster, N. J., and McClain, D. A. (1990) J. Biol. Chem. 265, 10132-10137). This region contains one copy of an NPXY sequence that is required for endocytosis of the low density lipoprotein receptor. In order to dissect and analyze the specific sequences involved in endocytosis of the insulin receptor, we have mutated the NPXY sequence from NPEY (residues 957-960) to APEA (NPEY/APEA). In addition, we have mutated a similar sequence in the same region, changing GPLY (residues 950-953) to APLA (GPLY/APLA). The cDNAs encoding the normal hIR and these mutant receptors were transfected into Rat 1 fibroblasts. The expressed receptors bound insulin with high affinity and retained insulin-stimulated tyrosine kinase activity. Despite the ability of these mutant receptors to bind insulin and undergo autophosphorylation, the GPLY/APLA receptor internalized insulin at only 32% of the rate of normal hIR at low receptor occupancy. On the other hand, the NPEY/APEA receptor internalized insulin at 87% of the normal rate. These results were confirmed by measuring internalization of photoaffinity-labeled insulin receptors. Another receptor with both the NPEY/APEA and GPLY/APLA mutations internalized to a lesser degree than the GPLY/APLA receptor and at a rate equivalent to that seen for a receptor with the entire submembranous domain deleted. A receptor with the complete normal submembranous domain but with the tyrosine kinase and C-terminal region of the hIR deleted exhibited only a basal internalization rate. We conclude that the information contained in the GPLY and, to a lesser extent, the NPEY sequences are necessary but not sufficient for signaling internalization of the insulin receptor. JF - The Journal of biological chemistry AU - Rajagopalan, M AU - Neidigh, J L AU - McClain, D A AD - Veterans Administration Medical Center, Birmingham, Alabama. Y1 - 1991/12/05/ PY - 1991 DA - 1991 Dec 05 SP - 23068 EP - 23073 VL - 266 IS - 34 SN - 0021-9258, 0021-9258 KW - DNA KW - 9007-49-2 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, Insulin KW - Index Medicus KW - Swine KW - Animals KW - Humans KW - Amino Acid Sequence KW - Protein-Tyrosine Kinases -- metabolism KW - Cloning, Molecular KW - Rats KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Phosphorylation KW - Transfection KW - Kinetics KW - Molecular Sequence Data KW - Cell Line KW - Receptor, Insulin -- chemistry KW - Endocytosis KW - Receptor, Insulin -- genetics KW - Receptor, Insulin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72517497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Amino+acid+sequences+Gly-Pro-Leu-Tyr+and+Asn-Pro-Glu-Tyr+in+the+submembranous+domain+of+the+insulin+receptor+are+required+for+normal+endocytosis.&rft.au=Rajagopalan%2C+M%3BNeidigh%2C+J+L%3BMcClain%2C+D+A&rft.aulast=Rajagopalan&rft.aufirst=M&rft.date=1991-12-05&rft.volume=266&rft.issue=34&rft.spage=23068&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-13 N1 - Date created - 1992-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pancreatic enlargement in alcoholic pancreatitis: prevalence and natural history. AN - 85203324; pmid-1722232 AB - We determined the prevalence and natural history of pancreatic enlargement by abdominal ultrasonography or computed tomography in 72 patients with alcoholic pancreatitis. Pancreatic enlargement was observed in 54 patients (75%); it was diffuse in 28 (52%) and focal in 26 (48%). The focal enlargement was frequently cystic (50%), while the diffuse enlargement was only occasionally cystic (7%). Sequential imaging of the pancreas in 29 patients demonstrated partial to total resolution of pancreatic enlargement in greater than 50% during 6 months of follow-up. Determination of serum amylase and p-isoamylase activity was neither sensitive nor specific for pancreatic enlargement in alcoholic pancreatitis. JF - Journal of Clinical Gastroenterology AU - Friedman, A D AU - Dutta, S K AU - Dubin, E H AU - Medhat, A AU - Keramati, B AU - Whitley, N AD - Department of Medicine, Veterans Administration Medical Center, University of Maryland School of Medicine, Baltimore. PY - 1991 SP - 666 EP - 672 VL - 13 IS - 6 SN - 0192-0790, 0192-0790 KW - Acute Disease KW - Human KW - Pancreas KW - Amylases KW - Tomography, X-Ray Computed KW - Aged KW - Hypertrophy KW - Prospective Studies KW - Isoamylase KW - Aged, 80 and over KW - Adult KW - Alcoholism KW - Middle Age KW - Male KW - Female KW - Pancreatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85203324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Pancreatic+enlargement+in+alcoholic+pancreatitis%3A+prevalence+and+natural+history.&rft.au=Friedman%2C+A+D%3BDutta%2C+S+K%3BDubin%2C+E+H%3BMedhat%2C+A%3BKeramati%2C+B%3BWhitley%2C+N&rft.aulast=Friedman&rft.aufirst=A&rft.date=1991-12-01&rft.volume=13&rft.issue=6&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The importance of hiatal hernia in reflux esophagitis compared with lower esophageal sphincter pressure or smoking. AN - 85203282; pmid-1761836 AB - The characteristics of gastroesophageal reflux disease have not been adequately defined. To determine the influence on the esophageal mucosa of hiatal hernia, lower esophageal sphincter pressure, acid reflux, and cigarettes and alcohol, we studied the reflux parameters, smoking habits, and alcohol consumption of 184 healthy, ambulatory outpatients who received endoscopy as the initial diagnostic procedure for workup of gastroesophageal reflux. Patients received endoscopic and histologic evaluations of the esophageal mucosa, prolonged ambulatory esophageal pH monitoring, and esophageal manometric determinations. Structural analysis was used to test the plausibility of various clinical theories concerning the most important factors contributing to the development of esophagitis. Statistical analyses revealed the following: (a) the lower esophageal sphincter pressure, acid contact time, and frequency of reflux episodes were highly associated with the presence of a hiatal hernia (p less than 0.003 for all parameters); (b) individuals with esophagitis had 16.5 times as many hiatal hernias as found in normal, healthy people; (c) cigarette smoking was not correlated with esophagitis but was significantly associated with increased lower esophageal sphincter pressure (r = 0.18; p less than 0.03); and (d) smoking was also not associated with increased acid contact time or increased frequency of reflux episodes. We conclude that (a) the presence of a hiatal hernia, not the pressure of the lower esophageal sphincter, is the most important predictor of reflux frequency, acid contact time, and esophagitis; (b) a decreased lower esophageal sphincter pressure, as suggested by structural analysis, is unlikely to be the cause of increased reflux episodes or esophagitis; and (c) if smoking and lower esophageal sphincter pressure are factors in the development of esophagitis, they damage the esophageal mucosa by mechanisms other than increased frequency of reflux episodes or increased acid contact time. JF - Journal of Clinical Gastroenterology AU - Sontag, S J AU - Schnell, T G AU - Miller, T Q AU - Nemchausky, B AU - Serlovsky, R AU - O'Connell, S AU - Chejfec, G AU - Seidel, U J AU - Brand, L AD - Department of Ambulatory, Veterans Administration Hospital, Hines, Illinois 60141. PY - 1991 SP - 628 EP - 643 VL - 13 IS - 6 SN - 0192-0790, 0192-0790 KW - Hernia, Hiatal KW - Smoking KW - Esophagitis, Peptic KW - Comparative Study KW - Computer Simulation KW - Models, Structural KW - Human KW - Esophagogastric Junction KW - Manometry KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85203282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=The+importance+of+hiatal+hernia+in+reflux+esophagitis+compared+with+lower+esophageal+sphincter+pressure+or+smoking.&rft.au=Sontag%2C+S+J%3BSchnell%2C+T+G%3BMiller%2C+T+Q%3BNemchausky%2C+B%3BSerlovsky%2C+R%3BO%27Connell%2C+S%3BChejfec%2C+G%3BSeidel%2C+U+J%3BBrand%2C+L&rft.aulast=Sontag&rft.aufirst=S&rft.date=1991-12-01&rft.volume=13&rft.issue=6&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Eye injury in a podiatrist. AN - 72700333; 1804955 JF - Journal of the American Podiatric Medical Association AU - Davis, J M AU - Kugler, G AU - Nixon, B P AD - Tucson Veterans Administration Medical Center, Tucson, AZ. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 661 EP - 663 VL - 81 IS - 12 SN - 8750-7315, 8750-7315 KW - Index Medicus KW - Eye Protective Devices KW - Humans KW - Eye Injuries, Penetrating -- etiology KW - Podiatry KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Eye Injuries, Penetrating -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72700333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Eye+injury+in+a+podiatrist.&rft.au=Davis%2C+J+M%3BKugler%2C+G%3BNixon%2C+B+P&rft.aulast=Davis&rft.aufirst=J&rft.date=1991-12-01&rft.volume=81&rft.issue=12&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-05 N1 - Date created - 1992-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lithium carbonate and mood disorder in recently detoxified alcoholics: a double-blind, placebo-controlled pilot study. AN - 72667982; 1789394 AB - The effects of lithium carbonate were assessed in a double-blind, placebo-controlled study of a small group of recently detoxified alcoholics. The patients were treated during their 2nd and 3rd week of abstinence. A previous study demonstrated the existence in these patients of a syndrome of mildly elevated psychomotor rate, including irritability, grandiosity, an increased need for social contact, loquaciousness, and sexual preoccupation. The intensity of this syndrome was significantly decreased by treatment with low dose lithium carbonate, with no effect of placebo treatment. JF - Alcoholism, clinical and experimental research AU - Nagel, K AU - Adler, L E AU - Bell, J AU - Nagamoto, H T AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, University of Colorado Health Sciences Center 80262. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 978 EP - 981 VL - 15 IS - 6 SN - 0145-6008, 0145-6008 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Ethanol -- adverse effects KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Double-Blind Method KW - Personality Inventory -- statistics & numerical data KW - Humans KW - Adult KW - Alcohol Withdrawal Delirium -- psychology KW - Pilot Projects KW - Middle Aged KW - Temperance KW - Psychometrics KW - Male KW - Lithium Carbonate -- therapeutic use KW - Alcoholism -- rehabilitation KW - Bipolar Disorder -- rehabilitation KW - Bipolar Disorder -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72667982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Lithium+carbonate+and+mood+disorder+in+recently+detoxified+alcoholics%3A+a+double-blind%2C+placebo-controlled+pilot+study.&rft.au=Nagel%2C+K%3BAdler%2C+L+E%3BBell%2C+J%3BNagamoto%2C+H+T%3BFreedman%2C+R&rft.aulast=Nagel&rft.aufirst=K&rft.date=1991-12-01&rft.volume=15&rft.issue=6&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-20 N1 - Date created - 1992-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dynorphins other than dynorphin A(1-17) lack spinal antianalgesic activity but do act on dynorphin A(1-17) receptors. AN - 72582030; 1684812 AB - In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t.) were shown not to have antianalgesic activity even at high doses (0.5-1 pmol). These Dyns, i.t., did not antagonize the antinociception produced by physostigmine administered i.c.v. or morphine given i.t. These Dyns lacked the intrinsic antianalgesic activity of Dyn A(1-17). However, they had affinity for Dyn A(1-17) receptors as shown in several ways. 1) The antagonism of physostigmine antinociception produced by Dyn A(1-17) given i.t. was reversed by these Dyns given together with Dyn A(1-17). 2) The effect of endogenously released Dyn A(1-17) was reversed. Administered i.c.v., clonidine simultaneously activates antinociceptive and antianalgesic systems [latter mediated spinally by Dyn A(1-17) release]. Thus, these Dyns given i.t. inhibited the action of endogenously released Dyn A(1-17) and allowed the full manifestation of the antinociceptive action of clonidine.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Rady, J J AU - Fujimoto, J M AU - Tseng, L F AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1073 EP - 1080 VL - 259 IS - 3 SN - 0022-3565, 0022-3565 KW - Peptide Fragments KW - 0 KW - Receptors, Opioid KW - dynorphin receptor KW - dynorphin (1-13) KW - 72957-38-1 KW - Dynorphins KW - 74913-18-1 KW - Morphine KW - 76I7G6D29C KW - Physostigmine KW - 9U1VM840SP KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Drug Interactions KW - Physostigmine -- pharmacology KW - Injections, Spinal KW - Peptide Fragments -- pharmacology KW - Mice KW - Male KW - Nociceptors -- drug effects KW - Morphine -- pharmacology KW - Dynorphins -- antagonists & inhibitors KW - Receptors, Opioid -- drug effects KW - Spinal Cord -- secretion KW - Spinal Cord -- drug effects KW - Dynorphins -- secretion KW - Dynorphins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72582030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Dynorphins+other+than+dynorphin+A%281-17%29+lack+spinal+antianalgesic+activity+but+do+act+on+dynorphin+A%281-17%29+receptors.&rft.au=Rady%2C+J+J%3BFujimoto%2C+J+M%3BTseng%2C+L+F&rft.aulast=Rady&rft.aufirst=J&rft.date=1991-12-01&rft.volume=259&rft.issue=3&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-07 N1 - Date created - 1992-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential effects of diabetes on adipocyte and liver phosphotyrosine and phosphoserine phosphatase activities. AN - 72576052; 1661692 AB - We examined the activities of particulate and cytosolic phosphotyrosine phosphatase (PTPase) and phosphoserine phosphatase (PSPase) in adipocytes and livers of diabetic rats. PTPase activity was assessed with [32P]tyrosine-phosphorylated insulin receptor (IR), whereas PSPase activity was assayed with [32P]serine-phosphorylated glycogen synthase. Diabetes increased adipocyte particulate PTPase activity and enhanced IR dephosphorylation by 75% on the 2nd, 93% on the 14th, and 108% on the 30th day. In contrast, cytosolic PTPase activity decreased by 78% on the 14th and 45% on the 30th day (no change on the 2nd day). Similar changes were observed with PSPase (increased activity in particulate and decreased in cytosolic). Insulin therapy for 14 or 30 days restored PTPase and PSPase activities in both fractions. Vanadate, despite rapid normalization of glycemia, restored these activities only after 30 days of therapy. Diabetes-related changes in liver PTPase activity were observed on the 14th day only. At this time, it was increased in both particulate and cytosolic fractions. There was spontaneous normalization of the liver PTPase activity at 30 days of diabetes. In contrast, liver cytosolic PSPase activity was significantly inhibited and not normalized by the 30th day of disease without therapy. In summary, diabetes appears to induce tissue-specific changes in PTPase and PSPase activities resulting in significant alterations in dephosphorylation of IR and glycogen synthase. Moreover, there appears to be a differential regulation of PTPase and PSPase activities in diabetes, particularly in the liver. JF - Diabetes AU - Begum, N AU - Sussman, K E AU - Draznin, B AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1620 EP - 1629 VL - 40 IS - 12 SN - 0012-1797, 0012-1797 KW - Ethers, Cyclic KW - 0 KW - Insulin KW - Macromolecular Substances KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Vanadates KW - 3WHH0066W5 KW - Glycogen Synthase KW - EC 2.4.1.11 KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - phosphoserine phosphatase KW - EC 3.1.3.3 KW - Protein Tyrosine Phosphatases KW - EC 3.1.3.48 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Reference Values KW - Vanadates -- pharmacology KW - Cytosol -- enzymology KW - Insulin -- therapeutic use KW - Ethers, Cyclic -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Glycogen Synthase -- metabolism KW - Kinetics KW - Male KW - Receptor, Insulin -- metabolism KW - Liver -- enzymology KW - Diabetes Mellitus, Experimental -- drug therapy KW - Protein Tyrosine Phosphatases -- metabolism KW - Liver -- drug effects KW - Adipose Tissue -- drug effects KW - Diabetes Mellitus, Experimental -- enzymology KW - Adipose Tissue -- enzymology KW - Phosphoric Monoester Hydrolases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72576052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Differential+effects+of+diabetes+on+adipocyte+and+liver+phosphotyrosine+and+phosphoserine+phosphatase+activities.&rft.au=Begum%2C+N%3BSussman%2C+K+E%3BDraznin%2C+B&rft.aulast=Begum&rft.aufirst=N&rft.date=1991-12-01&rft.volume=40&rft.issue=12&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-03 N1 - Date created - 1992-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Temafloxacin compared with ciprofloxacin in mild to moderate lower respiratory tract infections in ambulatory patients. A multicenter, double-blind, randomized study. AN - 72505474; 1659975 AB - The efficacy and safety of oral temafloxacin (600 mg) and ciprofloxacin (500 mg) twice daily for seven days were compared in patients with mild to moderate lower respiratory tract infections. Fifty-eight of 64 (91 percent) patients who received temafloxacin and 63 of 67 (94 percent) patients who received ciprofloxacin had clinical cure or improvement; bacteriologic cure occurred in 61 (95 percent) and 63 (94 percent), respectively. All 14 patients with pneumonia were clinically cured or improved and bacteriologically cured; 11 had complete resolution of roentgenographic evidence of pneumonia. Both quinolones eradicated most major respiratory pathogens. In the ciprofloxacin group, organisms persisted in three of seven Pseudomonas aeruginosa isolates and in one of eight Hemophilus parainfluenzae isolates; all these pathogens were eliminated with temafloxacin. Theophylline blood levels significantly increased by 25 percent in the ciprofloxacin group and decreased by 5 percent in the temafloxacin group. Adverse events, mostly dizziness, headache, and gastrointestinal effects, occurred in 43 percent of temafloxacin patients and in 31 percent of ciprofloxacin patients. JF - Chest AU - Chodosh, S AD - Veterans Administration Outpatient Clinic, Boston 02114. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1497 EP - 1502 VL - 100 IS - 6 SN - 0012-3692, 0012-3692 KW - Anti-Infective Agents KW - 0 KW - Fluoroquinolones KW - Quinolones KW - temafloxacin KW - 1WZ12GTT67 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Abridged Index Medicus KW - Index Medicus KW - Pneumonia -- microbiology KW - Double-Blind Method KW - Humans KW - Middle Aged KW - Pneumonia -- drug therapy KW - Microbial Sensitivity Tests KW - Lung Diseases, Obstructive -- complications KW - Male KW - Female KW - Ambulatory Care KW - Quinolones -- adverse effects KW - Anti-Infective Agents -- therapeutic use KW - Respiratory Tract Infections -- microbiology KW - Anti-Infective Agents -- adverse effects KW - Quinolones -- therapeutic use KW - Ciprofloxacin -- therapeutic use KW - Ciprofloxacin -- adverse effects KW - Respiratory Tract Infections -- drug therapy KW - Respiratory Tract Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Temafloxacin+compared+with+ciprofloxacin+in+mild+to+moderate+lower+respiratory+tract+infections+in+ambulatory+patients.+A+multicenter%2C+double-blind%2C+randomized+study.&rft.au=Chodosh%2C+S&rft.aulast=Chodosh&rft.aufirst=S&rft.date=1991-12-01&rft.volume=100&rft.issue=6&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-08 N1 - Date created - 1992-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The antiinflammatory effect of dopamine in alcoholic hemorrhagic pancreatitis in cats. Studies on the receptors and mechanisms of action. AN - 72491945; 1659548 AB - Hemorrhagic pancreatitis was induced in cats by perfusing pancreatic enzymes through a pancreatic duct after the administration of intragastric ethanol. Dimethyl prostaglandin E2 was administered concurrently. In the first study, dopamine's antiinflammatory effect on the pancreas was determined in the presence of haloperidol, propranolol, or both. Next, dopamine's effects on blood flow in the normal and inflamed pancreas were compared using a hydrogen gas-clearance technique. In the final study, the effect of dopamine on fluorescein isothiocyanate-labeled dextran leakage from the pancreatic duct to portal venous blood was investigated. It was found that blockade of either dopamine or beta-adrenergic receptors reduced, and blockade of both receptors completely eliminated, the antiinflammatory effect. Dopamine had no effect on pancreatic blood flow in normal cats. In pancreatitis, although dopamine transiently reduced blood flow, after an hour flow had returned to normal. Dopamine reversed the leakage of fluorescein isothiocyanate-labeled dextran from the pancreatic duct caused by ethanol and by ethanol and prostaglandin E2. It was concluded that dopamine ameliorated pancreatitis by reducing pancreatic ductal and/or microvascular permeability rather than by altering pancreatic blood flow. The antiinflammatory effect was mediated by both dopamine and beta-adrenergic receptors. JF - Gastroenterology AU - Karanjia, N D AU - Widdison, A L AU - Lutrin, F J AU - Chang, Y B AU - Reber, H A AD - Department of Surgery, Veterans Administration Medical Center, Sepulveda, California. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1635 EP - 1641 VL - 101 IS - 6 SN - 0016-5085, 0016-5085 KW - Prostaglandins E KW - 0 KW - Receptors, Adrenergic, beta KW - Receptors, Dopamine KW - Ethanol KW - 3K9958V90M KW - Propranolol KW - 9Y8NXQ24VQ KW - Haloperidol KW - J6292F8L3D KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Acute Disease KW - Animals KW - Prostaglandins E -- pharmacology KW - Ethanol -- pharmacology KW - Receptors, Adrenergic, beta -- immunology KW - Propranolol -- pharmacology KW - Haloperidol -- pharmacology KW - Cats KW - Receptors, Dopamine -- immunology KW - Receptors, Adrenergic, beta -- drug effects KW - Pancreas -- pathology KW - Dopamine -- pharmacology KW - Capillary Permeability -- drug effects KW - Pancreas -- drug effects KW - Pancreatitis -- etiology KW - Hemorrhage -- etiology KW - Hemorrhage -- drug therapy KW - Pancreatitis -- pathology KW - Dopamine -- therapeutic use KW - Hemorrhage -- pathology KW - Pancreas -- blood supply KW - Alcoholism -- complications KW - Pancreatitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72491945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=The+antiinflammatory+effect+of+dopamine+in+alcoholic+hemorrhagic+pancreatitis+in+cats.+Studies+on+the+receptors+and+mechanisms+of+action.&rft.au=Karanjia%2C+N+D%3BWiddison%2C+A+L%3BLutrin%2C+F+J%3BChang%2C+Y+B%3BReber%2C+H+A&rft.aulast=Karanjia&rft.aufirst=N&rft.date=1991-12-01&rft.volume=101&rft.issue=6&rft.spage=1635&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-02 N1 - Date created - 1992-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Conjugal transfer of antibiotic resistance factors in Bacteroides fragilis: the btgA and btgB genes of plasmid pBFTM10 are required for its transfer from Bacteroides fragilis and for its mobilization by IncP beta plasmid R751 in Escherichia coli. AN - 72452977; 1657890 AB - Transferable plasmids play an important role in the dissemination of clindamycin-erythromycin resistance in Bacteroides fragilis. We previously described the isolation and properties of pBFTM10, a 14.9-kb ClnR transfer factor from B. fragilis TMP10. We also reported the isolation of a transfer-deficient deletion derivative of pBFTM10 contained in the B. fragilis-Escherichia coli shuttle vector pGAT400. In the present study we used pGAT400 and a similar shuttle vector, pGAT550, to characterize and sequence a region of pBFTM10 required for its transfer from B. fragilis to B. fragilis or E. coli recipients and for its mobilization by the broad-host-range plasmid R751 from E. coli donors to E. coli recipients. Deletion of certain BglII restriction fragments from pBFTM10 resulted in partial or complete loss of transfer ability. Tn1000 insertions into this same region also resulted in altered transfer properties. We used the sites of Tn1000 insertions to determine the DNA sequence of the transfer region. Two potential open reading frames encoding proteins of 23.2 and 33.8 kDa, corresponding to two genes, btgA or btgB, were identified in the sequence. Tn1000 insertions within btgA or btgB or deletion of all or portions of btgA or btgB resulted in either a transfer deficiency or greatly reduced transfer from B. fragilis donors and alterations in mobilization by R751 in E. coli. A potential oriT sequence showing similarity in organization to the oriT regions of the IncP plasmids was also detected. Thus, pBFTM10 encodes and requires at least two proteins necessary for efficient transfer from B. fragilis. These same functions are expressed in E. coli and are required for mobilization by R751. JF - Journal of bacteriology AU - Hecht, D W AU - Jagielo, T J AU - Malamy, M H AD - Department of Medicine, Veterans Administration Hospital-Hines, Illinois 60141. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 7471 EP - 7480 VL - 173 IS - 23 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - DNA Transposable Elements KW - DNA, Bacterial KW - BtgA protein, Bacteroides fragilis KW - 145715-60-2 KW - BtgB protein, Bacteroides fragilis KW - 145715-61-3 KW - Clindamycin KW - 3U02EL437C KW - Erythromycin KW - 63937KV33D KW - Index Medicus KW - Phenotype KW - Protein Biosynthesis KW - Chromosome Deletion KW - Base Sequence KW - Bacterial Proteins -- genetics KW - DNA, Bacterial -- genetics KW - Restriction Mapping KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Plasmids KW - Mutagenesis, Insertional KW - R Factors KW - Genes, Bacterial KW - Bacteroides fragilis -- drug effects KW - Drug Resistance, Microbial -- genetics KW - Conjugation, Genetic KW - Clindamycin -- pharmacology KW - Escherichia coli -- genetics KW - Bacteroides fragilis -- genetics KW - Erythromycin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72452977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Conjugal+transfer+of+antibiotic+resistance+factors+in+Bacteroides+fragilis%3A+the+btgA+and+btgB+genes+of+plasmid+pBFTM10+are+required+for+its+transfer+from+Bacteroides+fragilis+and+for+its+mobilization+by+IncP+beta+plasmid+R751+in+Escherichia+coli.&rft.au=Hecht%2C+D+W%3BJagielo%2C+T+J%3BMalamy%2C+M+H&rft.aulast=Hecht&rft.aufirst=D&rft.date=1991-12-01&rft.volume=173&rft.issue=23&rft.spage=7471&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-26 N1 - Date created - 1991-12-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M77806; GENBANK; M64329; S65502; M64328; M64332; M64331; M63255; S65448; M64330; S65603 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1991 Jun 25;19(12):3455 [1648208] J Bacteriol. 1980 Sep;143(3):1362-73 [6251029] J Bacteriol. 1989 Jul;171(7):4100-3 [2544570] J Bacteriol. 1989 Jul;171(7):3603-8 [2544548] J Bacteriol. 1985 Dec;164(3):1248-55 [2999075] J Bacteriol. 1987 Aug;169(8):3573-80 [3038844] Crit Rev Microbiol. 1987;14(1):49-71 [3030631] Plasmid. 1987 Mar;17(2):87-109 [3039558] Plasmid. 1988 Nov;20(3):259-65 [3072579] Proc Natl Acad Sci U S A. 1989 Mar;86(6):1771-5 [2538813] J Biol Chem. 1989 Jul 15;264(20):11989-94 [2663846] Antimicrob Agents Chemother. 1988 May;32(5):717-22 [3395102] Proc Natl Acad Sci U S A. 1984 Nov;81(22):7203-6 [6095273] J Bacteriol. 1986 Jun;166(3):959-65 [3519587] J Bacteriol. 1984 May;158(2):739-41 [6725207] Antimicrob Agents Chemother. 1983 May;23(5):726-30 [6870222] Antimicrob Agents Chemother. 1983 Apr;23(4):536-40 [6859833] J Antimicrob Chemother. 1981 Dec;8 Suppl D:59-75 [7040329] Antimicrob Agents Chemother. 1982 Oct;22(4):701-3 [7181480] J Infect Dis. 1979 Jan;139(1):97-101 [108340] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Plasmid. 1979 Apr;2(2):261-8 [451051] J Infect Dis. 1979 Jan;139(1):83-8 [438530] J Mol Biol. 1978 Dec 15;126(3):347-65 [745233] J Bacteriol. 1990 May;172(5):2584-93 [2110145] Annu Rev Biochem. 1990;59:933-69 [2197994] J Biol Chem. 1990 Jun 25;265(18):10637-44 [2191955] Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1456-60 [1996345] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risks of blood volume changes in hypogonadal men treated with testosterone enanthate for erectile impotence. AN - 72452440; 1942342 AB - Administration of anabolic steroids carries many risks. We present a series of 15 patients with primary hypogonadism who as a group had statistically significant increases in whole body hematocrit and red blood cell volume while on testosterone therapy of 300 mg. intramuscularly every 3 weeks. A small decrease in plasma volume over-all was not significant. Subsequent analyses compared subgroups whose whole body hematocrit during testosterone therapy was either 48% or greater (9) or less than 48% (6). Interaction effects indicated that the subgroups were similar when off testosterone but when on testosterone the former group exhibited an increase in red blood cell volume and a decrease in plasma volume, while the latter group had little change in either measurement. Subsequent to stopping testosterone therapy 2 patients in the whole body hematocrit 48% or greater group suffered strokes and 1 had transient ischemic attacks while on therapy. No one in the whole body hematocrit less than 48% group has had any cerebrovascular symptoms. Clinical implications, as well as cost-effective and practical suggestions for detecting possible dangerous hemoconcentration are discussed. JF - The Journal of urology AU - Krauss, D J AU - Taub, H A AU - Lantinga, L J AU - Dunsky, M H AU - Kelly, C M AD - Veterans Administration Medical Center, Syracuse, New York. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1566 EP - 1570 VL - 146 IS - 6 SN - 0022-5347, 0022-5347 KW - Testosterone KW - 3XMK78S47O KW - testosterone enanthate KW - 7Z6522T8N9 KW - Abridged Index Medicus KW - Index Medicus KW - Plasma Volume -- drug effects KW - Cerebrovascular Disorders -- chemically induced KW - Humans KW - Hematocrit KW - Aged KW - Middle Aged KW - Erythrocyte Volume -- drug effects KW - Male KW - Testosterone -- analogs & derivatives KW - Testosterone -- therapeutic use KW - Erectile Dysfunction -- drug therapy KW - Testosterone -- adverse effects KW - Erectile Dysfunction -- etiology KW - Blood Volume -- drug effects KW - Hypogonadism -- complications KW - Hypogonadism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72452440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Risks+of+blood+volume+changes+in+hypogonadal+men+treated+with+testosterone+enanthate+for+erectile+impotence.&rft.au=Krauss%2C+D+J%3BTaub%2C+H+A%3BLantinga%2C+L+J%3BDunsky%2C+M+H%3BKelly%2C+C+M&rft.aulast=Krauss&rft.aufirst=D&rft.date=1991-12-01&rft.volume=146&rft.issue=6&rft.spage=1566&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-23 N1 - Date created - 1991-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of Exercise Training on Multiple Respiratory Variables in Patients with Coronary Artery Disease: Correlation with Change in Exercise Capacity AN - 20078606; 10100796 AB - Multiple measurements of pulmonary function were performed during exer cise testing in 29 patients with coronary artery disease (CAD) before and after exercise training. Following training, significant increases in oxygen consump tion (VO sub( 2)), carbon dioxide production (VCO sub(2)), and peak flow at maximal exer cise were seen as compared with pretraining values (p < .01), but not in any other respiratory variables. Only the peak respiratory exchange ratio (RER) achieved during pretraining exercise testing and peak values of minute ventilation (V sub(T)), respiratory rate, and VCO sub(2) during a posttraining exercise test showed signifi cant correlations with the change in maximum VO sub(2) following exercise training (p<.05). Significant correlations were also found among V sub(T), VCO sub(2), and peak flow at peak exercise following exercise training and the change in exercise du ration between pretraining and posttraining stress tests. Of 22 patients evaluat ed with thallium 201 scintigraphy during their pretraining exercise test, 11 developed ischemic ST depression or a reversible perfusion defect. No signifi cant differences in pulmonary function measurements during exercise testing were seen between patients who developed ischemia and those who did not. However, the change in peak metabolic equivalents (METS) achieved between pretraining and posttraining exercise was significantly greater in patients who developed ische mia (.836 plus or minus 1.003 versus .091 plus or minus .481, p<.05).These results indicate that exercise training in patients with CAD is not as sociated with significant changes in most measurements of pulmonary function and, with the exception of RER at peak exercise, pretraining measurements do no show a significant correlation with changes in exercise capacity. JF - Angiology AU - Stratmann, Henry AD - he Department of Cardiology, St. Louis Veterans Administration Medical Center and St. Louis University, St. Louis, Missouri Y1 - 1991/12// PY - 1991 DA - Dec 1991 SP - 948 EP - 956 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 42 IS - 12 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Measurement KW - Stress tests KW - Motor performance tests KW - Patients KW - Exercise KW - Exercise (effects) KW - Diseases KW - Exercise (programs) KW - Circulatory system KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Effect+of+Exercise+Training+on+Multiple+Respiratory+Variables+in+Patients+with+Coronary+Artery+Disease%3A+Correlation+with+Change+in+Exercise+Capacity&rft.au=Stratmann%2C+Henry&rft.aulast=Stratmann&rft.aufirst=Henry&rft.date=1991-12-01&rft.volume=42&rft.issue=12&rft.spage=948&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331979104201202 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Measurement; Stress tests; Motor performance tests; Patients; Diseases; Exercise (effects); Exercise; Exercise (programs); Circulatory system DO - http://dx.doi.org/10.1177/000331979104201202 ER - TY - JOUR T1 - Long-term enteral feeding: a retrospective comparison of delivery via percutaneous endoscopic gastrostomy and nasoenteric tubes. AN - 85228040; pmid-1951237 AB - The use of percutaneous endoscopic gastrostomy (PEG) tubes for enteral feeding is widespread, although their superiority to other feeding devices, such as nasoenteric tubes (NET), has not been substantiated. We retrospectively compared clinical outcomes in patients who received enteral feeding via PEG (n = 80) or NET (n = 29) from 1984 to 1988. Mean follow-up was 192 days in the PEG group and 141 days in the NET group. Changes in nutritional and performance status were similar in both groups. Aspiration pneumonia occurred within 14 days of tube placement in 6% and 24% (p = 0.01) of the PEG and NET patients, respectively. With the exception of tube replacement, cumulative rates of minor and major complications (including aspiration pneumonia) were similar in both groups during follow-up. None of the clinical variables that were assessed correlated with the development of aspiration pneumonia. Mortality was similar in both groups. These results suggest that, for long-term enteral feeding, PEG offers no substantial advantages over NET with respect to patient nutrition, performance, or survival. The reasons for the observed difference in short-term aspiration pneumonia rates are unknown, and must be investigated prospectively. JF - The American Journal of Gastroenterology AU - Fay, D E AU - Poplausky, M AU - Gruber, M AU - Lance, P AD - Department of Medicine, State University of New York School of Medicine and Biomedical Sciences, Veterans Administration Medical Center, Buffalo. PY - 1991 SP - 1604 EP - 1609 VL - 86 IS - 11 SN - 0002-9270, 0002-9270 KW - Gastroscopy KW - Analysis of Variance KW - Comparative Study KW - Human KW - Chi-Square Distribution KW - Retrospective Studies KW - Support, U.S. Gov't, Non-P.H.S. KW - Support, Non-U.S. Gov't KW - Aged KW - Time Factors KW - Male KW - Enteral Nutrition KW - Gastrostomy KW - Intubation, Gastrointestinal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85228040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Long-term+enteral+feeding%3A+a+retrospective+comparison+of+delivery+via+percutaneous+endoscopic+gastrostomy+and+nasoenteric+tubes.&rft.au=Fay%2C+D+E%3BPoplausky%2C+M%3BGruber%2C+M%3BLance%2C+P&rft.aulast=Fay&rft.aufirst=D&rft.date=1991-11-01&rft.volume=86&rft.issue=11&rft.spage=1604&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects. AN - 72695092; 1802900 AB - In this article we describe the immunocytochemical and electron microscopic findings in five patients with toxic epidermal necrolysis. They indicate the occurrence of necrotic keratinocytes with nuclear disintegration associated with apposed dendritic cells with the nuclear chromatin configuration of T lymphocytes. These findings, including the presence of blebbing of the keratinocytes and membrane defects associated with cytoplasmic processes from these apposed lymphoid cells, fit known electron microscopic criteria that suggest the involvement of T lymphocyte-mediated cytolysis of drug-altered target keratinocytes in toxic epidermal necrolysis. The effector cell appears to be a dendritic subset, with the phenotypic characteristics (CD3+, CD4-, CD8+, CD2+, DR+) of a T cell subset. There is some evidence that tumor necrosis factor alpha, secreted by activated macrophages, may play a role in necrolysis of the epidermis. The dramatic response of our patients to cyclophosphamide, which is known to inhibit cell-mediated cytotoxicity by inhibiting both the recognition and lethal hit stages, together with the rapid regrowth of the epidermis within 4 days to a week in patients who received adequate dosage of the drug, supports the preceding concepts. JF - Journal of the American Academy of Dermatology AU - Heng, M C AU - Allen, S G AD - Department of Medicine, University of California San Fernando Valley Internal Medicine Program, Veterans Administration Medical Center, Sepulveda 91343. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 778 EP - 786 VL - 25 IS - 5 Pt 1 SN - 0190-9622, 0190-9622 KW - Phenytoin KW - 6158TKW0C5 KW - Allopurinol KW - 63CZ7GJN5I KW - Ampicillin KW - 7C782967RD KW - Cyclophosphamide KW - 8N3DW7272P KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - Drug Therapy, Combination -- adverse effects KW - Basement Membrane -- ultrastructure KW - Chlorpropamide -- adverse effects KW - Infusions, Intravenous KW - Humans KW - Cell Membrane -- ultrastructure KW - Aged KW - Ampicillin -- adverse effects KW - Allopurinol -- adverse effects KW - Adult KW - Middle Aged KW - Microscopy, Electron KW - Keratinocytes -- pathology KW - Epidermis -- pathology KW - Phenytoin -- adverse effects KW - T-Lymphocyte Subsets -- pathology KW - Immunohistochemistry KW - Male KW - Cyclophosphamide -- administration & dosage KW - Cyclophosphamide -- therapeutic use KW - Stevens-Johnson Syndrome -- pathology KW - Stevens-Johnson Syndrome -- etiology KW - Stevens-Johnson Syndrome -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72695092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Efficacy+of+cyclophosphamide+in+toxic+epidermal+necrolysis.+Clinical+and+pathophysiologic+aspects.&rft.au=Heng%2C+M+C%3BAllen%2C+S+G&rft.aulast=Heng&rft.aufirst=M&rft.date=1991-11-01&rft.volume=25&rft.issue=5+Pt+1&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-30 N1 - Date created - 1992-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Acad Dermatol. 1993 Mar;28(3):511 [8445077] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metronidazole-induced acute pancreatitis. AN - 72619103; 1775854 AB - Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found. JF - Reviews of infectious diseases AU - Corey, W A AU - Doebbeling, B N AU - DeJong, K J AU - Britigan, B E AD - Department of Internal Medicine and Research Service, Veterans Administration Medical Center, Iowa City, Iowa. PY - 1991 SP - 1213 EP - 1215 VL - 13 IS - 6 SN - 0162-0886, 0162-0886 KW - Metronidazole KW - 140QMO216E KW - Index Medicus KW - Acute Disease KW - Risk Factors KW - Humans KW - Middle Aged KW - Female KW - Rectovaginal Fistula -- drug therapy KW - Metronidazole -- therapeutic use KW - Crohn Disease -- drug therapy KW - Metronidazole -- adverse effects KW - Rectovaginal Fistula -- complications KW - Pancreatitis -- chemically induced KW - Crohn Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72619103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Metronidazole-induced+acute+pancreatitis.&rft.au=Corey%2C+W+A%3BDoebbeling%2C+B+N%3BDeJong%2C+K+J%3BBritigan%2C+B+E&rft.aulast=Corey&rft.aufirst=W&rft.date=1991-11-01&rft.volume=13&rft.issue=6&rft.spage=1213&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 1992 Oct;15(4):750-1 [1384729] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arm abscesses caused by Clostridium botulinum. AN - 72616479; 1774288 AB - Wound botulism is an uncommon disorder that continues to be rarely reported in the United States. A 34-year-old intravenous heroin user was admitted to the Loma Linda, Calif., Veterans Administration hospital with multiple abscesses on his forearms. His clinical course was compatible with botulism, and his culture and serum were positive for Clostridium botulinum toxin type A. Early culture and/or serum identification can lead to prompt diagnosis, treatment, and improvement in the morbidity and mortality rates of this disease. JF - Journal of clinical microbiology AU - Elston, H R AU - Wang, M AU - Loo, L K AD - Clinical Microbiology Laboratory, Veterans Administration Hospital, Loma Linda, California 92357. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2678 EP - 2679 VL - 29 IS - 11 SN - 0095-1137, 0095-1137 KW - Index Medicus KW - Humans KW - Adult KW - Arm KW - Male KW - Substance Abuse, Intravenous KW - Clostridium botulinum -- pathogenicity KW - Botulism -- diagnosis KW - Wound Infection -- diagnosis KW - Botulism -- etiology KW - Clostridium botulinum -- isolation & purification KW - Wound Infection -- etiology KW - Abscess -- etiology KW - Abscess -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72616479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Arm+abscesses+caused+by+Clostridium+botulinum.&rft.au=Elston%2C+H+R%3BWang%2C+M%3BLoo%2C+L+K&rft.aulast=Elston&rft.aufirst=H&rft.date=1991-11-01&rft.volume=29&rft.issue=11&rft.spage=2678&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1985 May;102(5):616-8 [3985512] West J Med. 1987 Sep;147(3):335-8 [3314158] J Clin Microbiol. 1986 Mar;23(3):616-8 [3514662] JAMA. 1974 Sep 2;229(10):1305-8 [4604287] Am J Med. 1984 May;76(5):794-8 [6720725] J Trauma. 1981 Jan;21(1):68-71 [7463544] N Engl J Med. 1973 Nov 8;289(19):1005-10 [4582478] Am J Epidemiol. 1986 Nov;124(5):794-9 [3766512] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aspirin dose-dependently reduces alcohol-induced birth defects and prostaglandin E levels in mice. AN - 72612596; 1771594 AB - The purpose of the present study was threefold. The first purpose was to determine if aspirin (ASA) decreases alcohol-induced birth defects in mice in a dose-dependent fashion. The second purpose was to see if the antagonism of alcohol-induced birth defects afforded by ASA pretreatment was related to dose-dependent decreases in prostaglandin E (PGE) levels in uterine/embryo tissue. The third purpose was to determine if ASA pretreatment altered maternal blood alcohol level. In experiments 1 and 2, pregnant C57BL/6J mice were administered ASA (0, 18.75, 37.5, 75, 150, or 300 mg/kg) on gestation day 10. One hour following the subcutaneous injection of ASA, mice received alcohol (5.8 g/kg) or an isocaloric sucrose solution intragastrically. In experiment 1 the incidence of birth defects was assessed in fetuses delivered by caesarean section on gestation day 19. In experiment 2 uterine/embryo tissue samples were collected on gestation day 10 1 hr following alcohol intubation for subsequent PGE analysis. In experiment 3 blood samples were taken at five time points following alcohol intubation from separate groups of alcohol-treated pregnant mice pretreated with 150 mg/kg ASA or vehicle. The results from the three experiments indicated that 1) ASA dose-dependently reduced the frequency of alcohol-induced birth defects in fetuses examined at gestation day 19, (2) ASA decreased the levels of PGE in gestation day 10 uterine/embryo tissue in a similar dose-dependent fashion, and 3) ASA pretreatment did not significantly influence maternal blood alcohol levels. These results provide additional support for the hypothesis that PGs may play an important role in mediating the teratogenic actions of alcohol. JF - Teratology AU - Randall, C L AU - Anton, R F AU - Becker, H C AU - Hale, R L AU - Ekblad, U AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 521 EP - 529 VL - 44 IS - 5 SN - 0040-3709, 0040-3709 KW - Prostaglandins E KW - 0 KW - Ethanol KW - 3K9958V90M KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy KW - Ethanol -- blood KW - Fetus -- drug effects KW - Prostaglandins E -- blood KW - Prostaglandins E -- antagonists & inhibitors KW - Ethanol -- antagonists & inhibitors KW - Prostaglandins E -- analysis KW - Ethanol -- toxicity KW - Fetus -- chemistry KW - Aspirin -- pharmacology KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72612596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Aspirin+dose-dependently+reduces+alcohol-induced+birth+defects+and+prostaglandin+E+levels+in+mice.&rft.au=Randall%2C+C+L%3BAnton%2C+R+F%3BBecker%2C+H+C%3BHale%2C+R+L%3BEkblad%2C+U&rft.aulast=Randall&rft.aufirst=C&rft.date=1991-11-01&rft.volume=44&rft.issue=5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma. AN - 72587306; 1761775 AB - Both topical nitrogen mustard and psoralen photochemotherapy may induce benign and malignant alterations in the skin. We describe the explosive appearance of multiple epidermal cysts and squamous cell carcinomas in a patient whose cutaneous T-cell lymphoma was treated sequentially with these two types of therapy. This is the first report of both processes in the same patient with cutaneous T-cell lymphoma. It strongly supports the concept of lesion induction, while raising the question of an additive or even synergistic effect of these types of therapy. JF - Journal of the American Academy of Dermatology AU - Smith, S P AU - Konnikov, N AD - Department of Dermatology, Boston Veterans Administration Medical Center, MA 02130. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 940 EP - 943 VL - 25 IS - 5 Pt 2 SN - 0190-9622, 0190-9622 KW - Mechlorethamine KW - 50D9XSG0VR KW - Index Medicus KW - PUVA Therapy -- adverse effects KW - Administration, Cutaneous KW - Humans KW - Middle Aged KW - Male KW - Skin Neoplasms -- drug therapy KW - Epidermal Cyst -- chemically induced KW - Carcinoma, Squamous Cell -- pathology KW - Skin Neoplasms -- chemically induced KW - Epidermal Cyst -- pathology KW - Carcinoma, Squamous Cell -- chemically induced KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Mechlorethamine -- adverse effects KW - Lymphoma, T-Cell, Cutaneous -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72587306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Eruptive+epidermal+cysts+and+multiple+squamous+cell+carcinomas+after+therapy+for+cutaneous+T-cell+lymphoma.&rft.au=Smith%2C+S+P%3BKonnikov%2C+N&rft.aulast=Smith&rft.aufirst=S&rft.date=1991-11-01&rft.volume=25&rft.issue=5+Pt+2&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-11 N1 - Date created - 1992-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Acad Dermatol. 1992 Oct;27(4):651-2 [1401332] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Possible pathogenetic role of low-molecular-weight proteins in Balkan nephropathy. AN - 72570144; 1762343 AB - Balkan endemic nephropathy (BEN) is a tubulointerstitial disease characterized by increased-low-molecular-weight protein (LMWP), most notably, beta 2-microglobulin (beta 2m) excretion in urine. We previously demonstrated that two species of LMWPs, immunoglobulin light chains (LC) and recombinant alpha interferon (rIF), are toxic at proximal tubule cell membrane level. Myeloma LCs and rIF inhibit Na-dependent uptake of 14C-L-alanine and 14C-D-glucose by rat renal brush border membrane (BBM) vesicles at half-maximal inhibitory concentrations, IC50, ranging from 68 to 140 microM for LCs, and 5.4 to 18 nM for rIF. We further demonstrated that LCs bind to high-capacity, low-affinity sites on BBM with dissociation constants (Kd) ranging from 16 to 118 microM, a range similar to IC50s observed with the same LCs. Binding site occupancy is inversely related to alanine (r = -0.95, P less than 0.01), and glucose uptake (r = -0.96, P less than 0.01), implying that LC nephrotoxicity is determined by its binding to BBM. beta 2m shares behavioral and structural similarities with both LC and rIF. Preliminary studies in our laboratory showed that unlabeled LCs compete for the same binding sites on BBM with beta 2m. These observations confirm that all LMWP, including beta 2m, are potentially nephrotoxic. Thus, the characteristic beta 2-microglobulinuria of BEN may be more than a consequence of tubular dysfunction, and may play a pathogenetic role. JF - Kidney international. Supplement AU - Batuman, V AD - Renal Section, Veterans Administration Medical Center, East Orange, New Jersey. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - S89 EP - S92 VL - 34 SN - 0098-6577, 0098-6577 KW - Interferon Type I KW - 0 KW - Myeloma Proteins KW - Recombinant Proteins KW - beta 2-Microglobulin KW - Index Medicus KW - Animals KW - beta 2-Microglobulin -- metabolism KW - Humans KW - Microvilli -- metabolism KW - Interferon Type I -- metabolism KW - Myeloma Proteins -- metabolism KW - Kidney Cortex -- metabolism KW - Protein Binding KW - Molecular Weight KW - Rats KW - Kinetics KW - In Vitro Techniques KW - Balkan Nephropathy -- etiology KW - Balkan Nephropathy -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72570144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international.+Supplement&rft.atitle=Possible+pathogenetic+role+of+low-molecular-weight+proteins+in+Balkan+nephropathy.&rft.au=Batuman%2C+V&rft.aulast=Batuman&rft.aufirst=V&rft.date=1991-11-01&rft.volume=34&rft.issue=&rft.spage=S89&rft.isbn=&rft.btitle=&rft.title=Kidney+international.+Supplement&rft.issn=00986577&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of complement 5a receptor expression in U937 cells by phorbol ester. AN - 72567572; 1660914 AB - Receptors for the anaphylactic portion of complement, C5a, are not initially expressed in the monoblastic U937 cell line, but appear as the cell is induced to differentiate by the synergistic actions of 1,25(OH)2D and cyclic adenosine monophosphate (cAMP). Phorbol myristate acetate (PMA), which activates the protein kinase C pathway (PKC), does not cause C5a receptor (C5aR) expression when used as a single agent. The induction of C5aR by the synergistic actions of 1,25(OH)2D and cAMP, however, can be augmented as much as 180% by the addition of PMA. C5aR arising in cells exposed to 1,25(OH)2D and 8,4-chlorophenylthio-cAMP have an affinity constant of about 0.4 nM as assessed by cold competition analysis. We show here that when phorbol augmentation of receptor number occurs, the affinity constant is increased by 3.6-fold. In an effort to ascertain whether the change in C5aR Kd involved a PKC-dependent event we examined whether 5-60 min exposure of C5aR-positive cells to PMA would change C5aR Kd. Acutely, PMA caused a downregulation of receptor binding with decreases in apparent receptor number out of proportion to changes in Kd. One hundred nanomolar PMA, which effects nearly complete translocation of PKC to the membrane, consistently caused a 70-90% decrease in C5a surface binding. This downregulation was proportional to PMA dose and exposure time. Micromolar concentrations of the microtubule depolymerizing agents colchicine and vinblastine caused a less drastic downregulation, about 50% of the maximal phorbol effect. Our data suggest that activation of the PKC system might acutely limit the macrophage's ability to respond to C5a; chronically, phorbols upregulate receptor expression, most likely through positive effects on C5aR gene expression. JF - Journal of leukocyte biology AU - Rubin, J AU - Titus, L AU - Nanes, M S AD - Veterans Administration Medical Center, Atlanta, Decatur, GA 30033. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 502 EP - 508 VL - 50 IS - 5 SN - 0741-5400, 0741-5400 KW - Receptor, Anaphylatoxin C5a KW - 0 KW - Receptors, Complement KW - Vinblastine KW - 5V9KLZ54CY KW - Complement C5a KW - 80295-54-1 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Vinblastine -- pharmacology KW - Complement C5a -- metabolism KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- ultrastructure KW - Humans KW - Enzyme Activation -- physiology KW - Calcitriol -- pharmacology KW - Colchicine -- pharmacology KW - Protein Binding -- drug effects KW - Up-Regulation -- drug effects KW - Cyclic AMP -- pharmacology KW - Tumor Cells, Cultured -- pathology KW - Protein Kinase C -- physiology KW - Drug Synergism KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Gene Expression Regulation, Leukemic -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Receptors, Complement -- genetics KW - Receptors, Complement -- physiology KW - Receptors, Complement -- metabolism KW - Lymphoma, Large B-Cell, Diffuse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72567572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Regulation+of+complement+5a+receptor+expression+in+U937+cells+by+phorbol+ester.&rft.au=Rubin%2C+J%3BTitus%2C+L%3BNanes%2C+M+S&rft.aulast=Rubin&rft.aufirst=J&rft.date=1991-11-01&rft.volume=50&rft.issue=5&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-23 N1 - Date created - 1992-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intracoronary C5a induces myocardial ischemia by mechanisms independent of the neutrophil: leukocyte filters desensitize the myocardium to C5a. AN - 72551930; 1661246 AB - Activation of the complement cascade with the generation of anaphylatoxins accompanies the inflammatory response elicited by acute myocardial ischemia and reperfusion. Although complement is activated in the interstitium during acute myocardial ischemia, we have studied mechanisms whereby complement might exacerbate ischemia by using a model employing intracoronary injection of C5a in nonischemic hearts. Intracoronary injection of complement component C5a induces transient myocardial ischemia, mediated through the production of the coronary vasoconstrictors thromboxane A2 and peptidoleukotrienes (LTC4, LTD4), and causes sequestration of polymorphonuclear leukocytes (PMN) in the coronary vascular bed. To further investigate the role of the PMN in the C5a-induced vasoconstriction, the left anterior descending coronary artery (LAD) in pigs was perfused at constant pressure and measurements of coronary blood flow, myocardial contractile function (sonomicrometry), arterial/coronary venous blood PMN count, and thromboxane B2 (TxB2) levels were performed. The myocardial response to intracoronary C5a (500 ng) was determined before, during, and after perfusion with blood depleted of PMNs using leukocyte filters (Sepacell R-500, Pall PL-100). In additional animals, the myocardial response to the PMN chemotactic agent, LTB4, and the effects of intracoronary C5a during constant flow perfusion were measured. Control intracoronary injection of C5a decreased flow (41% of baseline) and contractile function (39% of baseline), PMNs were trapped (5.1 x 10(3) cells/microliters), and TxB2 concentration increased in coronary venous blood. The response to C5a during coronary perfusion with arterial blood depleted of PMNs with Sepacell or Pall filters (less than 0.1 x 10(3) cells/microliters) was greatly blunted, with flow and contractile function falling by less than 14 and 8%, respectively, from baseline, and release of TxB2 was greatly attenuated. However, the myocardial ischemia and TxB2 release remained depressed in response to C5a after removal of the filters and perfusion with either arterial blood containing normal levels of PMNs or stored arterial blood never exposed to filters. In contrast, the repeat C5a challenge resulted in equivalent myocardial extraction of PMNs, thus indicating a dissociation of PMN sequestration from the acute ischemic response and release of TxB2. In separate experiments, the intracoronary injection of LTB4 also resulted in a pronounced myocardial extraction of PMNs (8.6 x 10(3) cells/microliters) greater than during C5a, but did not depress coronary flow or function. Perfusion at constant flow greatly diminished the ischemic response to C5a, indicating that vasoconstriction and resultant ischemia is the main cause of the contractile dysfunction. These data indicate that leukocyte filters inhibit the myocardial ischemia and release of TxB2 induced by C5a via mechanisms not related to PMN depletion.(ABSTRACT TRUNCATED AT 400 WORDS) JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Engler, R L AU - Roth, D M AU - del Balzo, U AU - Ito, B R AD - Department of Medicine and Pathology, Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2983 EP - 2991 VL - 5 IS - 14 SN - 0892-6638, 0892-6638 KW - SRS-A KW - 0 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Swine KW - Myocardial Reperfusion Injury -- chemically induced KW - Hemodynamics -- drug effects KW - Myocardial Reperfusion Injury -- blood KW - Animals KW - Leukotriene B4 -- blood KW - Coronary Vessels KW - Injections, Intra-Arterial KW - Filtration -- instrumentation KW - SRS-A -- blood KW - Myocardial Reperfusion Injury -- physiopathology KW - Cell Adhesion KW - Coronary Disease -- blood KW - Coronary Disease -- physiopathology KW - Coronary Disease -- chemically induced KW - Neutrophils -- physiology KW - Complement C5a -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72551930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Intracoronary+C5a+induces+myocardial+ischemia+by+mechanisms+independent+of+the+neutrophil%3A+leukocyte+filters+desensitize+the+myocardium+to+C5a.&rft.au=Engler%2C+R+L%3BRoth%2C+D+M%3Bdel+Balzo%2C+U%3BIto%2C+B+R&rft.aulast=Engler&rft.aufirst=R&rft.date=1991-11-01&rft.volume=5&rft.issue=14&rft.spage=2983&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-29 N1 - Date created - 1992-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Production of a factor, or factors, suppressing IL-2 production and T cell proliferation by Sertoli cell-enriched preparations. A potential role for islet transplantation in an immunologically privileged site. AN - 72482432; 1949171 AB - Isolated islet allografts survive indefinitely in the abdominal testis of nonimmunosuppressed diabetic rats. The predominant feature of these testes is that the presence of Sertoli cells, but not Leydig cells, is required for extended survival of the islet allografts. Sertoli cells cultures were therefore established in vitro and we examined the effects of the conditioned media on Con A--stimulated spleen lymphocyte proliferation. These studies revealed that a product(s) secreted by Sertoli cells inhibits Con A-stimulated lymphocyte proliferation in a dose-dependent manner. The synthesis of this product is both temperature-dependent, occurring predominantly at 37 degrees C, and hormone-dependent, requiring the presence of follicle stimulating hormone, in the culture medium. We further examined the mechanism of inhibition of lymphocyte proliferation and showed that Sertoli cell-enriched media inhibit the production of IL-2 in a dose-dependent manner. Furthermore, the finding that the addition of exogenous IL-2 is not able to reverse this inhibition indicates that the Sertoli cell-enriched media inhibit both IL-2 production and IL-2 responsiveness of T lymphocytes. JF - Transplantation AU - Selawry, H P AU - Kotb, M AU - Herrod, H G AU - Lu, Z N AD - Veterans Administration Medical Center, Memphis, Tennessee. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 846 EP - 850 VL - 52 IS - 5 SN - 0041-1337, 0041-1337 KW - Interleukin-2 KW - 0 KW - Concanavalin A KW - 11028-71-0 KW - Testosterone KW - 3XMK78S47O KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Index Medicus KW - Animals KW - Rats, Inbred Strains KW - Rats KW - Testosterone -- pharmacology KW - Cells, Cultured KW - Dose-Response Relationship, Immunologic KW - In Vitro Techniques KW - Hot Temperature -- adverse effects KW - Cytotoxicity Tests, Immunologic KW - Follicle Stimulating Hormone -- pharmacology KW - Drug Antagonism KW - Female KW - Male KW - Lymphocyte Activation -- drug effects KW - Interleukin-2 -- biosynthesis KW - Sertoli Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72482432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Production+of+a+factor%2C+or+factors%2C+suppressing+IL-2+production+and+T+cell+proliferation+by+Sertoli+cell-enriched+preparations.+A+potential+role+for+islet+transplantation+in+an+immunologically+privileged+site.&rft.au=Selawry%2C+H+P%3BKotb%2C+M%3BHerrod%2C+H+G%3BLu%2C+Z+N&rft.aulast=Selawry&rft.aufirst=H&rft.date=1991-11-01&rft.volume=52&rft.issue=5&rft.spage=846&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-16 N1 - Date created - 1991-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes. Role of hydroxyl radical and protection by heat shock. AN - 72451308; 1658042 AB - Leishmania must survive despite exposure to the toxic oxidant hydrogen peroxide (H2O2) during phagocytosis by macrophages. We investigated the mechanism of H2O2 toxicity for L. donovani chagasi promastigotes, and factors responsible for their relative H2O2 resistance. There was a dose-dependent toxic effect of H2O2 for promastigotes isolated during logarithmic phase of growth. In contrast, stationary phase promastigotes were less susceptible to H2O2 toxicity, and more infectious for BALB/c mice. By spin trapping we found that hydroxyl radical (.OH) was generated after exposure of promastigotes to H2O2, and the amount of .OH was greater with log-phase than with stationary-phase promastigotes. .OH was generated after the addition of H2O2 to the cytosol but not the membranes of fractionated promastigotes, and the magnitude of .OH was greater in log than in stationary promastigote cytosol. Deferoxamine inhibition suggested that intracellular promastigote iron catalyzes .OH formation via the Fenton reaction. Furthermore, exposure of log-phase promastigotes to heat shock induced a relative H2O2-resistant state, which was not associated with a decrease in .OH formation but which required ongoing transcription. Thus, growth to stationary phase and heat shock both induce a state of relative H2O2 resistance, but these are probably due to different resistance mechanisms. JF - The Journal of clinical investigation AU - Zarley, J H AU - Britigan, B E AU - Wilson, M E AD - Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 1511 EP - 1521 VL - 88 IS - 5 SN - 0021-9738, 0021-9738 KW - Cyclic N-Oxides KW - 0 KW - Heat-Shock Proteins KW - Hydroxides KW - Hydroxyl Radical KW - 3352-57-6 KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Deferoxamine KW - J06Y7MXW4D KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Abridged Index Medicus KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals KW - Deferoxamine -- pharmacology KW - Humans KW - Macrophages -- physiology KW - Heat-Shock Proteins -- biosynthesis KW - Transcription, Genetic KW - Mice KW - Phagocytosis KW - Hot Temperature KW - Hydrogen Peroxide -- pharmacology KW - Leishmania donovani -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72451308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Hydrogen+peroxide-mediated+toxicity+for+Leishmania+donovani+chagasi+promastigotes.+Role+of+hydroxyl+radical+and+protection+by+heat+shock.&rft.au=Zarley%2C+J+H%3BBritigan%2C+B+E%3BWilson%2C+M+E&rft.aulast=Zarley&rft.aufirst=J&rft.date=1991-11-01&rft.volume=88&rft.issue=5&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-13 N1 - Date created - 1991-12-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1987 Nov;55(11):2802-6 [3666964] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4414-7 [3859870] Acta Physiol Scand Suppl. 1986;548:9-37 [3019082] Arch Biochem Biophys. 1986 May 1;246(2):501-14 [3010861] Annu Rev Med. 1986;37:61-9 [3010809] J Biol Chem. 1986 Apr 5;261(10):4426-31 [3007455] Eur J Immunol. 1987 Feb;17(2):203-8 [3030768] Infect Immun. 1988 Feb;56(2):363-9 [2962944] Cell. 1986 Sep 26;46(7):959-61 [2944601] J Immunol. 1991 Apr 15;146(8):2747-53 [1707920] Curr Top Microbiol Immunol. 1991;167:125-43 [2055094] Mol Biochem Parasitol. 1990 Sep-Oct;42(2):225-33 [2176718] Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1313-9 [2123614] J Immunol. 1987 Nov 1;139(9):3099-106 [3312412] J Bacteriol. 1988 Sep;170(9):3910-4 [3045081] Science. 1988 Jun 3;240(4857):1302-9 [3287616] J Bacteriol. 1989 Jul;171(7):3933-9 [2472381] Annu Rev Biochem. 1986;55:1151-91 [2427013] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2453-7 [2538841] Immunol Today. 1989 Oct;10(10):328-33 [2679629] Eur J Biochem. 1989 Mar 15;180(2):267-72 [2647489] Nucleic Acids Res. 1989 Jul 11;17(13):5081-95 [2762121] J Immunol. 1989 Jul 15;143(2):678-84 [2738406] Proc Natl Acad Sci U S A. 1989 Apr;86(8):2607-11 [2704738] Immunol Today. 1988 May;9(5):134-7 [3256318] EMBO J. 1988 Sep;7(9):2895-901 [3181145] J Immunol. 1988 Jul 1;141(1):265-72 [3379307] Exp Parasitol. 1988 Feb;65(1):1-9 [3338542] Infect Immun. 1987 Mar;55(3):587-93 [3546131] Parasitology. 1985 Oct;91 ( Pt 2):207-17 [4069752] Parasitology. 1985 Oct;91 ( Pt 2):197-206 [4069751] Science. 1985 Jun 21;228(4706):1443-6 [4012301] J Immunol. 1990 Jun 15;144(12):4794-7 [2351828] J Immunol. 1990 Jan 1;144(1):278-83 [2104889] Science. 1990 May 11;248(4956):730-2 [1970672] J Biol Chem. 1990 Feb 15;265(5):2973-8 [2406243] J Clin Invest. 1983 Jul;72(1):32-44 [6308049] J Biol Chem. 1984 Sep 25;259(18):11173-5 [6088532] J Immunol. 1982 Jul;129(1):351-7 [6282967] J Biol Chem. 1981 Jul 25;256(14):7094-6 [6265438] J Reticuloendothel Soc. 1981 Mar;29(3):181-92 [6260943] Rev Infect Dis. 1983 Sep-Oct;5(5):907-927 [6356272] Cell. 1983 Dec;35(3 Pt 2):603-10 [6606489] Science. 1984 Mar 30;223(4643):1417-9 [6701528] J Immunol. 1983 Oct;131(4):1994-9 [6619546] J Immunol. 1982 Sep;129(3):1282-6 [7108206] J Exp Med. 1981 Jun 1;153(6):1690-5 [7252424] J Exp Med. 1981 May 1;153(5):1302-15 [7252418] J Immunol. 1980 Nov;125(5):2195-201 [7430624] J Exp Med. 1977 Dec 1;146(6):1613-26 [925613] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Science. 1986 Mar 7;231(4742):1154-7 [3511530] Biochem Biophys Res Commun. 1987 Oct 29;148(2):653-7 [3689364] J Immunol. 1987 Jan 1;138(1):299-305 [3782801] J Immunol. 1986 Jun 15;136(12):4681-8 [3711662] J Exp Med. 1985 Jul 1;162(1):324-31 [3891904] Nucleic Acids Res. 1988 Oct 25;16(20):9567-85 [3186441] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outreach Health Services for Street Youth AN - 61644429; 199302066 AB - Based on a review of charts & clinic logs, medical problems are explored among 609 youths, average age 16 years, 9 months, seen 1985-1989 at a voluntary health agency operating a clinic at a drop-in center for street youth in Portland, Ore. There were 2,086 diagnoses made during 1,895 visits. Respiratory, dermatologic, & gynecologic problems represented 56% of all diagnoses. Pregnancy tests accounted for 38% of all procedures, 50% of all medications dispensed were either oral antibiotics or decongestants, & 17% of the visits resulted in referrals. Problems related to substance abuse & sexually transmitted diseases were seen much less frequently than anticipated. Elements critical to the success of this clinic included its on-site location, hours of operation, close working relationships between clinic & center staffs, the capability to perform a few simple laboratory procedures, & an on-site pharmacy. 4 Tables, 26 References. Adapted from the source document. JF - Journal of Adolescent Health AU - Reuler, James B AD - Section General Medicine Veterans Administration Medical Center, PO Box 1034 Portland OR 92207 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 561 EP - 566 VL - 12 IS - 7 SN - 1054-139X, 1054-139X KW - medical problems, street youths KW - charts, clinic logs KW - drop-in center, Portland, Oregon KW - Portland, Oregon KW - Health Problems KW - Youth KW - Homelessness KW - article KW - 6124: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61644429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Outreach+Health+Services+for+Street+Youth&rft.au=Reuler%2C+James+B&rft.aulast=Reuler&rft.aufirst=James&rft.date=1991-11-01&rft.volume=12&rft.issue=7&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Homelessness; Youth; Portland, Oregon; Health Problems ER - TY - JOUR T1 - Right Hemisphere Participation in Reading AN - 58243208; 9200630 AB - It was hypothesized that the right cerebral hemisphere's contribution to lexical semantic processing, in skilled readers, is greatest when the hemisphere is "released" from inhibition. An experiment was designed using a set of tasks to overload the left hemisphere, thus disinhibiting right-hemisphere reading processes. Right-handed undergraduates (N = 18 males & 15 females) were tested in four dual-task & five single-task conditions. The primary task was a lateralized semantic or rhyme task. Visual stimuli were presented tachistoscopically & Ss were instructed to press a response button with the hand ipsilateral to the stimulus. Reaction time for correct "related" trials (those in which the centrally presented target word & laterally presented word were semantically related or phonologically related) were analyzed. The pattern of results suggests that interhemispheric inhibition & disinhibition are greater in some individuals than in others. The degree of inhibition of right-hemisphere function in the single-task semantic conditions was associated with the degree of disinhibition in the dual-task left visual field semantic condition. For one subgroup, findings supported the initial hypothesis. Some suggestions for future research are outlined. 1 Table, 1 Figure, 72 References. B. Annesser Murray JF - Brain and Language AU - Hutner, Nancy AU - Liederman, Jacqueline AD - Boston Veterans Administration Medical Center, 150 South Huntington Ave MA 02130 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 475 EP - 495 VL - 41 IS - 4 SN - 0093-934X, 0093-934X KW - right hemisphere role, lexical semantic processing, inhibition release effects KW - empirical data KW - undergraduates KW - Cerebral Dominance (11500) KW - Handedness (30450) KW - Brain (09350) KW - Reading Processes (71150) KW - article KW - 4119: applied linguistics; reading processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58243208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Right+Hemisphere+Participation+in+Reading&rft.au=Hutner%2C+Nancy%3BLiederman%2C+Jacqueline&rft.aulast=Hutner&rft.aufirst=Nancy&rft.date=1991-11-01&rft.volume=41&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Brain (09350); Reading Processes (71150); Cerebral Dominance (11500); Handedness (30450) ER - TY - JOUR T1 - Writing with the Right Hemisphere AN - 58214956; 9200156 AB - The possible role of the right cerebral hemisphere in writing & spelling is discussed with reference to the case history of a patient suffering a massive left-hemisphere stroke that virtually destroyed that hemisphere. A detailed analysis was conducted of the patient's remaining language abilities, including oral language, writing, oral spelling, & reading. It is assumed that these abilities were relegated only to the right hemisphere after the stroke. The patient was totally uanble to spell nonwords to dictation, but could write real words. This writing, however, was significantly affected by lexical-semantic variables, eg, word frequency & part of speech. The patient could write some words correctly but could not spell orally at all. It is suggested that the linguistic abilities of this patient may have been greater than expected due to continued linguistic development following his unusual survivial of the massive stroke. 2 Tables, 1 Figure, 71 References. B. Annesser Murray JF - Brain and Language AU - Rapcsak, Steven Z AU - Beeson, Pelagie M AU - Rubens, Alan B AD - Neurology Service Veterans Administration Medical Center, 3601 South 6th Ave Tucson AZ 85723 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 510 EP - 530 VL - 41 IS - 4 SN - 0093-934X, 0093-934X KW - right hemisphere role, writing words/nonwords KW - case history KW - Cerebral Dominance (11500) KW - Nervous System Disorders (57100) KW - Writing Disorders (98650) KW - Neurolinguistics (57250) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58214956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Writing+with+the+Right+Hemisphere&rft.au=Rapcsak%2C+Steven+Z%3BBeeson%2C+Pelagie+M%3BRubens%2C+Alan+B&rft.aulast=Rapcsak&rft.aufirst=Steven&rft.date=1991-11-01&rft.volume=41&rft.issue=4&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Cerebral Dominance (11500); Neurolinguistics (57250); Nervous System Disorders (57100); Writing Disorders (98650) ER - TY - JOUR T1 - A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. AN - 72484151; 1719969 AB - Protein kinase C (PKC) is routinely assayed, after it is partially purified over DEAE-cellulose chromatography to eliminate any interfering protein kinases and phosphatases, by measuring the transfer of gamma-phosphate of [gamma-32P]ATP to H1 histone. Recently, it has been shown that a synthetic peptide, comprising residues 4-14 of myelin basic protein (MBP4-14), is a very selective PKC substrate which is not phosphorylated effectively by cyclic AMP-dependent protein kinase, casein kinase I and II, Ca2+/calmodulin dependent protein kinase II or phosphorylase kinase [Yasuda, I., Kishimoto, A., Tanaka, S-I., Tominaga, M., Sakurai, A. and Nishizuka, Y. (1990) BBRC 166, 1220-1227]. We report here that once MBP4-14 is phosphorylated, it is not dephosphorylated by okadaic acid-sensitive phosphatases (protein phosphatases 1, 2A and 3) or other protein phosphatases such as calcineurin and/or PP 2C present in hippocampal homogenates. Therefore, MBP4-14 can be used for PKC assay in crude extracts of neural tissue. JF - Biochemical and biophysical research communications AU - Farrar, Y J AU - Vanaman, T C AU - Slevin, J T AD - Veterans Administration Medical Center, Lexington, KY 40511. Y1 - 1991/10/31/ PY - 1991 DA - 1991 Oct 31 SP - 694 EP - 701 VL - 180 IS - 2 SN - 0006-291X, 0006-291X KW - Ethers, Cyclic KW - 0 KW - Myelin Basic Protein KW - Oligopeptides KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Protein Kinase C KW - EC 2.7.11.13 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Index Medicus KW - Animals KW - Amino Acid Sequence KW - Myelin Basic Protein -- chemical synthesis KW - Ethers, Cyclic -- pharmacology KW - Oligopeptides -- chemical synthesis KW - Rats, Inbred Strains KW - Rats KW - Chromatography, DEAE-Cellulose KW - Kinetics KW - Molecular Sequence Data KW - Myelin Basic Protein -- metabolism KW - Substrate Specificity KW - Male KW - Adenosine Triphosphate -- pharmacology KW - Protein Kinase C -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Protein Kinase C -- isolation & purification KW - Hippocampus -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=A+phosphatase+resistant+substrate+for+the+assay+of+protein+kinase+C+in+crude+tissue+extracts.&rft.au=Farrar%2C+Y+J%3BVanaman%2C+T+C%3BSlevin%2C+J+T&rft.aulast=Farrar&rft.aufirst=Y&rft.date=1991-10-31&rft.volume=180&rft.issue=2&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-02 N1 - Date created - 1991-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction. AN - 72174495; 1932130 AB - The mechanism of phospholipase A2 activation by chemotactic peptide was investigated in human promyelocytic HL60 cells. N-Formyl-methionyl-leucyl-phenylalanine (fMetLeuPhe) and the non-hydrolyzable GTP analogue guanosine 5'-[gamma-thio]triphosphate (GTP[S]) induced arachidonic acid release in permeabilized and metabolically inhibited HL60 cells, a preparation in which calcium was buffered and inositol phospholipid hydrolysis was inhibited. Inositol phosphate generation and arachidonic acid were shown to be temporally dissociated. These results suggest that receptor-dependent phospholipase C activity is not required for fMetLeuPhe to induce arachidonic acid release. However, fMetLeuPhe effects were highly calcium-dependent and inhibition of phospholipase C reduced fMetLeuPhe stimulation of arachidonic acid release even in the permeabilized cell preparation. We conclude that although phospholipase A2 activation is linked to the fMetLeuPhe receptor independent of phospholipase C, actions of phospholipase C to mobilize calcium and release diacylglycerol may be important to phospholipase A2 activation in the intact cell. JF - Biochimica et biophysica acta AU - Nielson, C P AU - Stutchfield, J AU - Cockcroft, S AD - Clinical Pharmacology and Gerontology Research Unit, Veterans Administration Medical Center, Boise, ID. Y1 - 1991/10/16/ PY - 1991 DA - 1991 Oct 16 SP - 83 EP - 89 VL - 1095 IS - 1 SN - 0006-3002, 0006-3002 KW - Inositol Phosphates KW - 0 KW - Neomycin KW - 1404-04-2 KW - Arachidonic Acid KW - 27YG812J1I KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Type C Phospholipases KW - EC 3.1.4.- KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Tumor Cells, Cultured KW - Inositol Phosphates -- metabolism KW - Enzyme Activation KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Neomycin -- pharmacology KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Phospholipases A -- metabolism KW - Adenosine Triphosphate -- pharmacology KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - GTP-Binding Proteins -- metabolism KW - Signal Transduction KW - Arachidonic Acid -- metabolism KW - Type C Phospholipases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72174495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Chemotactic+peptide+stimulation+of+arachidonic+acid+release+in+HL60+cells%2C+an+interaction+between+G+protein+and+phospholipase+C+mediated+signal+transduction.&rft.au=Nielson%2C+C+P%3BStutchfield%2C+J%3BCockcroft%2C+S&rft.aulast=Nielson&rft.aufirst=C&rft.date=1991-10-16&rft.volume=1095&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-11 N1 - Date created - 1991-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunological effects of levamisole in vitro. AN - 72640435; 1790137 AB - Levamisole, an anthelminthic drug with immunological properties, has recently been reported to have antitumor activity when administered with 5-fluorouracil in patients with Duke's C colorectal carcinoma. The mechanism of this antitumor effect is unknown, but has been postulated to be related to levamisole's immunomodulatory properties. To define further the immunomodulatory activities of levamisole, we studied the in vitro effects of levamisole on monocyte and lymphocyte cytotoxicity, activation, and proliferation; induction of cytokine-induced proteins; and expression of tumor-associated antigens. Experiments utilized peripheral blood mononuclear cells from normal donors incubated in the presence of increasing concentrations of levamisole (0.1 to 100 micrograms/ml). Levamisole had no consistent effect on induction of 2',5'-oligoadenylate synthetase activity or indoleamine-2,3-dioxygenase activity, or production of tumor necrosis factor. Levamisole had no effect on monocyte cytotoxicity or expression of HLA-DR, HLA-DQ, HLA-DP, and the Fc receptor. Similarly, levamisole had no significant effect on NK or LAK cytotoxicity or the immunological activation of T-lymphocytes, assessed by expression of CD3, CD4, CD8, CD16, CD25, and CD56. Proliferation of lymphocytes from normal donors, patients with benign polyps, and patients with malignancies, with or without IL-2 or irradiated LS174T cells, was not significantly increased overall. No significant enhancement in the expression of three tumor-associated antigens (880364, NRCO-4, and ING-1) and the intercellular adhesion molecule-1 (ICAM-1) antigen on four human cancer cell lines was observed following in vitro exposure to levamisole. We conclude that levamisole is not a potent modulator of the immune parameters we examined, and that the mechanism behind the unique clinical interaction between levamisole and 5-fluorouracil in colorectal carcinoma remains to be identified. JF - Journal of immunotherapy : official journal of the Society for Biological Therapy AU - Schiller, J H AU - Lindstrom, M AU - Witt, P L AU - Hank, J A AU - Mahvi, D AU - Wagner, R J AU - Sondel, P AU - Borden, E C AD - Department of Human Oncology, William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 297 EP - 306 VL - 10 IS - 5 SN - 1053-8550, 1053-8550 KW - Antigens, Neoplasm KW - 0 KW - Antigens, Surface KW - Antineoplastic Agents KW - Tumor Necrosis Factor-alpha KW - Levamisole KW - 2880D3468G KW - Tryptophan Oxygenase KW - EC 1.13.11.11 KW - 2',5'-Oligoadenylate Synthetase KW - EC 2.7.7.84 KW - Index Medicus KW - Tryptophan Oxygenase -- biosynthesis KW - Humans KW - Killer Cells, Lymphokine-Activated -- immunology KW - Antigens, Neoplasm -- analysis KW - Cell Division -- drug effects KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - 2',5'-Oligoadenylate Synthetase -- biosynthesis KW - Tryptophan Oxygenase -- metabolism KW - Tumor Cells, Cultured KW - Monocytes -- immunology KW - Cytotoxicity Tests, Immunologic KW - Monocytes -- drug effects KW - 2',5'-Oligoadenylate Synthetase -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunophenotyping KW - Lymphocytes -- drug effects KW - Antigens, Surface -- analysis KW - Killer Cells, Natural -- immunology KW - Levamisole -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72640435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.atitle=Immunological+effects+of+levamisole+in+vitro.&rft.au=Schiller%2C+J+H%3BLindstrom%2C+M%3BWitt%2C+P+L%3BHank%2C+J+A%3BMahvi%2C+D%3BWagner%2C+R+J%3BSondel%2C+P%3BBorden%2C+E+C&rft.aulast=Schiller&rft.aufirst=J&rft.date=1991-10-01&rft.volume=10&rft.issue=5&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.issn=10538550&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Signal transduction by the human thyrotropin receptor: studies on the role of individual amino acid residues in the carboxyl terminal region of the third cytoplasmic loop. AN - 72628596; 1663578 AB - We observed previously that the carboxyl-terminal region of the third loop of the TSH receptor (amino acid residues 617-625) is important in signal transduction. To analyze this region in more detail, in the present study we used site-directed mutagenesis to substitute, on an individual basis, the seven amino acids previously mutated as a group. These amino acids are either charged residues or potential phosphorylation sites. Six of the mutant TSH receptors with individual amino acid substitutions bound TSH with high affinity and displayed a cAMP response to TSH stimulation similar to the wild-type TSH receptor. The mutant receptor TSH-R-Gly625 (Arg----Gly) did not transduce a signal, but these results are noninformative because of the loss of high affinity TSH binding. The present data indicate that for each of the six informative amino acid substitutions, the individual residues are not critical for signal transduction. A corollary of this conclusion is that in the important carboxyl-terminal region of the third cytoplasmic loop of the TSH receptor multiple amino acid residues function as a unit. JF - Molecular endocrinology (Baltimore, Md.) AU - Chazenbalk, G D AU - Nagayama, Y AU - Wadsworth, H AU - Russo, D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 1523 EP - 1526 VL - 5 IS - 10 SN - 0888-8809, 0888-8809 KW - Receptors, Thyrotropin KW - 0 KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Models, Structural KW - Transfection KW - Kinetics KW - Humans KW - Genetic Vectors KW - Restriction Mapping KW - Molecular Sequence Data KW - Cyclic AMP -- metabolism KW - CHO Cells KW - Amino Acid Sequence KW - Protein Conformation KW - Cricetinae KW - Mutagenesis, Site-Directed KW - Thyrotropin -- pharmacology KW - Receptors, Thyrotropin -- physiology KW - Thyrotropin -- metabolism KW - Signal Transduction KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72628596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Signal+transduction+by+the+human+thyrotropin+receptor%3A+studies+on+the+role+of+individual+amino+acid+residues+in+the+carboxyl+terminal+region+of+the+third+cytoplasmic+loop.&rft.au=Chazenbalk%2C+G+D%3BNagayama%2C+Y%3BWadsworth%2C+H%3BRusso%2C+D%3BRapoport%2C+B&rft.aulast=Chazenbalk&rft.aufirst=G&rft.date=1991-10-01&rft.volume=5&rft.issue=10&rft.spage=1523&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A randomized trial of cefepime (BMY-28142) and ceftazidime for the treatment of pneumonia. AN - 72586696; 1761451 AB - Cefepime is a new cephalosporin with a broad antimicrobial spectrum that includes Staphylococcus aureus and Pseudomonas aeruginosa. To study the efficacy and safety of cefepime for treatment of pneumonia, 65 patients were randomized to therapy with either cefepime or ceftazidime at a two to one ratio. Of the 57 evaluable patients, 89% of the cefepime patients and 84% of the ceftazidime patients were cured clinically or improved. Haemophilus spp., Streptococcus pneumoniae, and Neisseria spp. were common pathogens. Bacteriological cure was achieved in 31 (91%) of cefepime patients and 17 (100%) ceftazidime patients. Adverse clinical and laboratory reactions possibly due to study drug occurred in 9 (21%) cefepime patients and in 1 (5%) ceftazidime patient. Most reactions were mild and resolved with discontinuation of study drug. In this study, cefepime appeared as effective as ceftazidime for the treatment of pneumonia. JF - The Journal of antimicrobial chemotherapy AU - Edelstein, H AU - Chirurgi, V AU - Oster, S AU - Karp, R AU - Cassano, K AU - Aiken, S AU - McCabe, R AD - Medical Service, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 569 EP - 575 VL - 28 IS - 4 SN - 0305-7453, 0305-7453 KW - Cephalosporins KW - 0 KW - cefepime KW - 807PW4VQE3 KW - Ceftazidime KW - 9M416Z9QNR KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Bacteria -- drug effects KW - Aged KW - Middle Aged KW - Microbial Sensitivity Tests KW - Drug Hypersensitivity KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Ceftazidime -- adverse effects KW - Pneumonia -- microbiology KW - Ceftazidime -- therapeutic use KW - Cephalosporins -- therapeutic use KW - Pneumonia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72586696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=A+randomized+trial+of+cefepime+%28BMY-28142%29+and+ceftazidime+for+the+treatment+of+pneumonia.&rft.au=Edelstein%2C+H%3BChirurgi%2C+V%3BOster%2C+S%3BKarp%2C+R%3BCassano%2C+K%3BAiken%2C+S%3BMcCabe%2C+R&rft.aulast=Edelstein&rft.aufirst=H&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ceftibuten versus cefaclor for the treatment of bronchitis. AN - 72580426; 1761452 AB - Ceftibuten is an oral third generation cephalosporin with potent antimicrobial activity against Enterobacteriaceae, beta-lactamase positive Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrheae, penicillin-susceptible pneumococci, and beta-hemolytic streptococci. To study the efficacy and safety of ceftibuten for treatment of bronchitis, 58 patients were randomized to therapy with either ceftibuten 400 mg once a day or cefaclor 250 mg every 8 h at a ratio of two to one. Of 45 clinically evaluable patients, 28 (87.5%) of the 32 ceftibuten patients and 12 (92.3%) of the 13 cefaclor patients were clinically improved or cured. Of 33 microbiologically evaluable patients, 21 (87.5%) of the 24 ceftibuten patients and eight (80%) of the ten cefaclor patients were cured. Of 56 patients evaluable for adverse effects, three (7.9%) of the 38 ceftibuten patients and one (5.6%) of the 18 cefaclor patients had adverse reactions. In this small study, once-daily ceftibuten appeared as safe and as effective as cefaclor for the treatment of bronchitis. JF - The Journal of antimicrobial chemotherapy AU - Chirurgi, V A AU - Edelstein, H AU - Oster, S E AU - Karp, R AU - Cassano, K B AU - Aiken, S AU - Krumpe, P AU - McCabe, R E AD - Medical Service, Veterans Administration Medical Center, Martinez, California USA 94553. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 577 EP - 580 VL - 28 IS - 4 SN - 0305-7453, 0305-7453 KW - Cephalosporins KW - 0 KW - Cefaclor KW - 69K7K19H4L KW - ceftibuten KW - IW71N46B4Y KW - Index Medicus KW - Humans KW - Bacteria -- drug effects KW - Microbial Sensitivity Tests KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Bronchitis -- drug therapy KW - Cefaclor -- therapeutic use KW - Cefaclor -- administration & dosage KW - Cephalosporins -- therapeutic use KW - Bronchitis -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72580426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Ceftibuten+versus+cefaclor+for+the+treatment+of+bronchitis.&rft.au=Chirurgi%2C+V+A%3BEdelstein%2C+H%3BOster%2C+S+E%3BKarp%2C+R%3BCassano%2C+K+B%3BAiken%2C+S%3BKrumpe%2C+P%3BMcCabe%2C+R+E&rft.aulast=Chirurgi&rft.aufirst=V&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Noncirrhotic liver dysfunction and neuropsychologic impairment. AN - 72568209; 1755526 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 899 EP - 900 VL - 15 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Hepatic Encephalopathy -- psychology KW - Hepatic Encephalopathy -- diagnosis KW - Liver Diseases, Alcoholic -- psychology KW - Substance-Related Disorders -- psychology KW - Neuropsychological Tests KW - Liver Diseases, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Noncirrhotic+liver+dysfunction+and+neuropsychologic+impairment.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-10-01&rft.volume=15&rft.issue=5&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-28 N1 - Date created - 1992-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antabuse (disulfiram) and AIDS. AN - 72563698; 1684488 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 900 EP - 901 VL - 15 IS - 5 SN - 0145-6008, 0145-6008 KW - Carbamates KW - 0 KW - Disulfides KW - dioxiram KW - 59547-11-4 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - AIDS/HIV KW - Leukocyte Count -- drug effects KW - Humans KW - CD4-Positive T-Lymphocytes -- drug effects KW - Disulfides -- pharmacokinetics KW - Alcoholism -- rehabilitation KW - Carbamates -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Disulfiram -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- immunology KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Aldehyde Dehydrogenase -- antagonists & inhibitors KW - Disulfiram -- pharmacokinetics KW - Disulfides -- therapeutic use KW - Alcoholism -- immunology KW - Carbamates -- pharmacokinetics KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72563698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Antabuse+%28disulfiram%29+and+AIDS.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-10-01&rft.volume=15&rft.issue=5&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-28 N1 - Date created - 1992-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacological evaluation of early afterdepolarisations induced by sea anemone toxin (ATXII) in dog heart. AN - 72550010; 1684137 AB - ATXII is a polypeptide toxin isolated from the sea anemone, Anemonia sulcata, known to delay sodium inactivation markedly and to induce early afterdepolarisations. The aim was to investigate the mechanism of its action. The mechanism of ATXII induced early afterdepolarisations was investigated in vitro in canine endocardial preparations using standard microelectrode techniques. ATXII (2 x 10(-7) M) induced cycle length dependent prolongation of plateau, more marked in Purkinje than in muscle fibres, and early afterdepolarisations in Purkinje fibres only. The calcium channel antagonists verapamil (10(-6) M, 10(-5) M) and cobalt (2-4 mM), and drugs that block calcium release from the sarcoplasmic reticulum, ryanodine (10(-6) M, 10(-5) M) and caffeine (10 mM), did not antagonise the ATXII effects. However, tetrodotoxin (5 x 10(-6) M) and lignocaine (4 x 10(-5) M) shortened the action potential and suppressed early afterdepolarisations. The effects of lignocaine were seen at concentrations that did not significantly affect Vmax. ATXII induced early after depolarisations are due to the effects of ATXII on Na+ entry, probably via a slowly inactivated Na+ channel population. Calcium entry through the sarcolemmal Ca2+ channels and cyclic Ca2+ release from the sarcoplasmic reticulum are not required for the genesis of early afterdepolarisations in this model. JF - Cardiovascular research AU - Boutjdir, M AU - el-Sherif, N AD - Cardiology Division (111), Veterans Administration Medical Center (State University of New York), Brooklyn 11209. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 815 EP - 819 VL - 25 IS - 10 SN - 0008-6363, 0008-6363 KW - Calcium Channels KW - 0 KW - Cardiotonic Agents KW - Cnidarian Venoms KW - Sodium Channels KW - toxin II (Anemonia sulcata) KW - 60748-45-0 KW - Index Medicus KW - Purkinje Fibers -- drug effects KW - Evoked Potentials -- drug effects KW - Animals KW - Sea Anemones KW - Culture Techniques KW - Calcium Channels -- physiology KW - Sarcoplasmic Reticulum -- physiology KW - Dogs KW - Sodium Channels -- physiology KW - Electric Stimulation KW - Sodium Channels -- drug effects KW - Cardiotonic Agents -- pharmacology KW - Endocardium -- drug effects KW - Endocardium -- physiology KW - Cnidarian Venoms -- antagonists & inhibitors KW - Cnidarian Venoms -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72550010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+research&rft.atitle=Pharmacological+evaluation+of+early+afterdepolarisations+induced+by+sea+anemone+toxin+%28ATXII%29+in+dog+heart.&rft.au=Boutjdir%2C+M%3Bel-Sherif%2C+N&rft.aulast=Boutjdir&rft.aufirst=M&rft.date=1991-10-01&rft.volume=25&rft.issue=10&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+research&rft.issn=00086363&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-22 N1 - Date created - 1992-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Similarities and differences between MMPI and MMPI-2 applications to the assessment of posttraumatic stress disorder. AN - 72486576; 1955973 AB - The purpose of this study was to address the question: Is the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) comparable to the original MMPI in its applicability to the assessment of posttraumatic stress disorder (PTSD) among Vietnam combat veterans? The question was addressed by administering both the original MMPI and MMPI-2 to 29 subjects classified as meeting Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; DSM-III-R) criteria for PTSD and comparing MMPI and MMPI-2 scores in terms of: degree of association, code-type congruence, diagnostic hit rates (when compared to two other clinical samples, and one normal sample), and congruence of the Keane PTSD Scale (PK). Results reveal highly significant correlations between MMPI and MMPI-2 basic scales for the PTSD sample as well as congruence in 2-point codes comparable to previous studies. The MMPI-2 was found to identify effectively PTSD subjects from the other groups. Results also showed a high degree of association between the MMPI and MMPI-2 in regard to PK scores, although minor differences were found in PK raw scores between the two tests. Overall, the findings suggest a high degree of comparability between the MMPI and MMPI-2 in the assessment of PTSD. JF - Journal of personality assessment AU - Litz, B T AU - Penk, W E AU - Walsh, S AU - Hyer, L AU - Blake, D D AU - Marx, B AU - Keane, T M AU - Bitman, D AD - Boston Veterans Administration Medical Center. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 238 EP - 253 VL - 57 IS - 2 SN - 0022-3891, 0022-3891 KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Reproducibility of Results KW - Humans KW - Adult KW - Middle Aged KW - Substance-Related Disorders -- psychology KW - Psychometrics KW - Male KW - Female KW - Vietnam KW - Combat Disorders -- psychology KW - Veterans -- psychology KW - MMPI -- statistics & numerical data KW - Combat Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72486576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+assessment&rft.atitle=Similarities+and+differences+between+MMPI+and+MMPI-2+applications+to+the+assessment+of+posttraumatic+stress+disorder.&rft.au=Litz%2C+B+T%3BPenk%2C+W+E%3BWalsh%2C+S%3BHyer%2C+L%3BBlake%2C+D+D%3BMarx%2C+B%3BKeane%2C+T+M%3BBitman%2C+D&rft.aulast=Litz&rft.aufirst=B&rft.date=1991-10-01&rft.volume=57&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-30 N1 - Date created - 1991-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extreme hyperkalemia induced by drugs. AN - 72149715; 1924001 AB - Because of age and disease-induced pathophysiologic changes, elderly and diabetic patients are prone to hyperkalemia under even the best of circumstances. Further complicating the situation is the fact that the drugs often prescribed for these populations can affect potassium homeostasis. Drs Rigolin and Chap describe a case in which an elderly diabetic man with azotemia survived extreme drug-induced hyperkalemia. JF - Postgraduate medicine AU - Rigolin, V H AU - Chap, L AD - Northwestern University Medical School/Veterans Administration Lakeside Medical Center, Chicago. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 129 EP - 131 VL - 90 IS - 5 SN - 0032-5481, 0032-5481 KW - Diuretics KW - 0 KW - Insulin KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Diuretics -- adverse effects KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Humans KW - Diabetes Mellitus, Type 2 -- complications KW - Aged KW - Diabetes Mellitus, Type 2 -- metabolism KW - Potassium -- administration & dosage KW - Potassium -- metabolism KW - Male KW - Insulin -- adverse effects KW - Hyperkalemia -- therapy KW - Hyperkalemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72149715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Extreme+hyperkalemia+induced+by+drugs.&rft.au=Rigolin%2C+V+H%3BChap%2C+L&rft.aulast=Rigolin&rft.aufirst=V&rft.date=1991-10-01&rft.volume=90&rft.issue=5&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Murine peritoneal macrophage gangliosides inhibit lymphocyte proliferation. AN - 72137156; 1919364 AB - Gangliosides have been shown to act as immunoregulatory agents by altering proliferative responses of lymphocytes to both antigens and mitogens. Most early studies have utilized brain gangliosides and have required high concentrations. The role of endogenous gangliosides from macrophages has remained unexplored. In this study, thioglycolate-elicited murine peritoneal macrophage gangliosides were purified and added to cultures of murine lymphocytes. Nanogram amounts caused a profound inhibition of LPS-induced DNA synthesis of splenocytes and of purified B lymphocytes, without demonstrable cellular toxicity. No effect was seen using asialo-GM1. This effect was present across a wide range of lipopolysaccharide (LPS) doses. Nanogram amounts of macrophage gangliosides also inhibited concanavalin A (ConA)-mediated lymphocyte proliferation. Inhibition of LPS-induced mitogenesis was present even if gangliosides were removed from the extracellular environment after 15-60 min of incubation prior to the addition of LPS. This inhibition was reversible with incubation of ganglioside pre-treated lymphocytes in medium containing serum. These inhibitory properties of macrophage gangliosides are distinct from those found in studies using brain gangliosides, and support a potential role for macrophage gangliosides as negative modulators of lymphocyte proliferation. JF - Journal of leukocyte biology AU - Berenson, C S AU - Ryan, J L AD - Infectious Disease Section, West Haven Veterans Administration Medical Center, Connecticut. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 393 EP - 401 VL - 50 IS - 4 SN - 0741-5400, 0741-5400 KW - Gangliosides KW - 0 KW - Lipopolysaccharides KW - Concanavalin A KW - 11028-71-0 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice KW - Female KW - Macrophages -- cytology KW - Lymphocyte Activation -- drug effects KW - Gangliosides -- analysis KW - Peritoneal Cavity -- cytology KW - Macrophages -- chemistry KW - Gangliosides -- pharmacology KW - Macrophages -- metabolism KW - Gangliosides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72137156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Murine+peritoneal+macrophage+gangliosides+inhibit+lymphocyte+proliferation.&rft.au=Berenson%2C+C+S%3BRyan%2C+J+L&rft.aulast=Berenson&rft.aufirst=C&rft.date=1991-10-01&rft.volume=50&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. The VA Cooperative Study Group (No. 119) AN - 72134156; 1655605 AB - Patients with overt alcoholic liver disease who had participated in a multicenter therapeutic trial and subgroups of controls (i.e., alcoholic patients without liver disease and patients with neither alcoholism nor liver disease) were tested for hepatitis B virus and hepatitis C virus antibodies to determine the prevalence of these antibodies to determine the prevalence of these antibodies and any clinical association in the progression and outcome of alcoholic liver disease. Antibodies to hepatitis B (anti-HBs and/or anti-HBc) were found in 29.2% of patients with alcoholic liver disease, in 26.1% of hospitalized alcoholic patients without liver disease and in 24.2% of hospitalized nonalcoholic patients without liver disease; frequencies were not significantly different from one another. HBsAg was not evaluated because HBsAg+ patients had been excluded from the original trial. The presence of these antibody markers correlated with ethnic origin of and immunoglobulin levels in the patients. In contrast, antibody to hepatitis C, as detected by enzyme immunoassay, was positive in 27.1%, 4.8% and 3.0% of the three groups, respectively, the first differing significantly from the other two. Antibody to hepatitis C virus positivity correlated significantly with clinical severity of the disease and with the presence of histological features that imply chronic viral infection (periportal inflammation, cirrhosis), despite the fact that the supplementary assay for antibody to hepatitis C virus, using recombinant immunoblot assay, reduced the positive rate by 79%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Mendenhall, C L AU - Seeff, L AU - Diehl, A M AU - Ghosn, S J AU - French, S W AU - Gartside, P S AU - Rouster, S D AU - Buskell-Bales, Z AU - Grossman, C J AU - Roselle, G A AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 581 EP - 589 VL - 14 IS - 4 Pt 1 SN - 0270-9139, 0270-9139 KW - Antibodies, Viral KW - 0 KW - Hepatitis B Antibodies KW - Index Medicus KW - Regression Analysis KW - Immunoblotting KW - Humans KW - Adult KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Survival Analysis KW - Liver Cirrhosis, Alcoholic -- immunology KW - Hepatitis, Alcoholic -- immunology KW - Hepacivirus -- immunology KW - Hepatitis, Alcoholic -- mortality KW - Liver Cirrhosis, Alcoholic -- mortality KW - Hepatitis B Antibodies -- analysis KW - Antibodies, Viral -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72134156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Antibodies+to+hepatitis+B+virus+and+hepatitis+C+virus+in+alcoholic+hepatitis+and+cirrhosis%3A+their+prevalence+and+clinical+relevance.+The+VA+Cooperative+Study+Group+%28No.+119%29&rft.au=Mendenhall%2C+C+L%3BSeeff%2C+L%3BDiehl%2C+A+M%3BGhosn%2C+S+J%3BFrench%2C+S+W%3BGartside%2C+P+S%3BRouster%2C+S+D%3BBuskell-Bales%2C+Z%3BGrossman%2C+C+J%3BRoselle%2C+G+A&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1991-10-01&rft.volume=14&rft.issue=4+Pt+1&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 1991 Oct;14(4 Pt 1):730-3 [1655608] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. AN - 72118372; 1910817 AB - Cadmium exposure is capable of causing acute and chronic lung injuries, but the specific pathogenetic mechanisms are uncertain. The effects of cadmium ion (Cd2+) on phospholipid metabolism were examined in cultured bovine pulmonary artery endothelial cells (BPAEC), as endothelial cells appear to be particularly vulnerable to the toxic effects of this metallic ion. Exposure of radiolabeled BPAEC to millimolar concentrations of Cd2+ causes liberation of substantial amounts of [3H]arachidonic acid ([3H]AA), but only small amounts of [14C]stearic acid, from each of the major phospholipid subclasses. Analyses of hydrolytic products in BPAEC radiolabeled with [3H]myo-inositol and exposed to Cd2+ indicate that degradation of complex phospholipids is mediated by phospholipase A2. The ability of BPAEC to incorporate fatty acids or lysophosphatides into complex phospholipids is similarly impaired after exposure to Cd2+, suggesting that the liberation of [3H]AA might be due to impairment of reacylation mechanisms and not to increased hydrolytic activity of phospholipase A2. Of the two enzymes involved in reacylation reactions, Cd2+ is found to inhibit the activity of arachidonyl-specific acyl coenzyme A synthetase but not the activity of acyltransferase. Cd2+ also causes a profound time- and dose-dependent depletion of adenosine triphosphate levels in BPAEC, and these changes closely correlate with the liberation of [3H]AA. We suggest that impairment of reacylation mechanisms, and the consequent accumulation of arachidonic acid, may be important in the development of the acute inflammatory reaction that is characteristic of Cd(2+)-induced lung injury. JF - American journal of respiratory cell and molecular biology AU - Nelson, J M AU - Duane, P G AU - Rice, K L AU - Niewoehner, D E AD - Pulmonary Section-111N, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 328 EP - 336 VL - 5 IS - 4 SN - 1044-1549, 1044-1549 KW - Cations, Divalent KW - 0 KW - Fatty Acids, Nonesterified KW - Lysophosphatidylcholines KW - Phospholipids KW - Stearic Acids KW - Cadmium KW - 00BH33GNGH KW - Arachidonic Acid KW - 27YG812J1I KW - stearic acid KW - 4ELV7Z65AP KW - Inositol KW - 4L6452S749 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Animals KW - Inositol -- metabolism KW - Arachidonic Acid -- metabolism KW - Chromatography, High Pressure Liquid KW - Cattle KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Adenosine Triphosphate -- metabolism KW - Lysophosphatidylcholines -- metabolism KW - Stearic Acids -- metabolism KW - Fatty Acids, Nonesterified -- metabolism KW - Phospholipases A -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Phospholipids -- metabolism KW - Cadmium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Cadmium+ion-induced+alterations+of+phospholipid+metabolism+in+endothelial+cells.&rft.au=Nelson%2C+J+M%3BDuane%2C+P+G%3BRice%2C+K+L%3BNiewoehner%2C+D+E&rft.aulast=Nelson&rft.aufirst=J&rft.date=1991-10-01&rft.volume=5&rft.issue=4&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-15 N1 - Date created - 1991-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trajectories of Health: In Concept and Empirical Pattern AN - 61313825; 9400343 AB - A model is presented of physical & emotional health trajectories over the approximately 45 years of adult life, based on data from the oldest longitudinal study still active in the US (initiated by L. M. Terman, 1925) on 857 men, identifying broad patterns of stability & change in health 1940-1986. Qualitative data analysis is used to describe trajectories characteristics of most individuals, & quantitative analysis to differentiate these patterns using individual & medical characteristics. The value of this approach to measure health longitudinally involves a focus on the sequence of health transitions in lives. 4 Tables, 1 Figure, 43 References. Adapted from the source document. JF - Behavior, Health, and Aging AU - Clipp, Elizabeth Colerick AU - Pavalko, Eliza K AU - Elder, Glen H, Jr AD - Veterans Administration Medical Center, Durham NC 27705 Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 159 EP - 179 VL - 2 IS - 3 SN - 1049-085X, 1049-085X KW - health trajectories, longitudinal analysis KW - 1940-1986 qualitative/quantitative data KW - men, US KW - Life Cycle KW - Males KW - Health Problems KW - United States of America KW - Health KW - Adults KW - article KW - 0394: social psychology; life cycle & biography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61313825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior%2C+Health%2C+and+Aging&rft.atitle=Trajectories+of+Health%3A+In+Concept+and+Empirical+Pattern&rft.au=Clipp%2C+Elizabeth+Colerick%3BPavalko%2C+Eliza+K%3BElder%2C+Glen+H%2C+Jr&rft.aulast=Clipp&rft.aufirst=Elizabeth&rft.date=1991-10-01&rft.volume=2&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Behavior%2C+Health%2C+and+Aging&rft.issn=1049085X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - BHAGEG N1 - SubjectsTermNotLitGenreText - Health; Adults; Health Problems; Life Cycle; United States of America; Males ER - TY - JOUR T1 - Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections. AN - 72161401; 1656740 AB - This was a randomized, third-party-blinded, multicenter study that compared once-daily azithromycin (500 mg on day 1, followed by 250 mg on days 2-5) to cefaclor (500 mg three times daily for 10 days) in the treatment of patients with acute bronchitis or pneumonia. A total of 546 patients were entered into the study and 272 patients were evaluable for efficacy analysis. Of these, 249 (176 azithromycin, 73 cefaclor) had bronchitis and 23 (15 azithromycin, 8 cefaclor) had pneumonia. The combined clinical cure and improvement rate, as determined by the investigator, was 96% for azithromycin and 94% for cefaclor, with 88% bacteriologic eradication in both treatment groups. The elimination of Haemophilus influenzae was significantly better with azithromycin (94.5%) than with cefaclor (61.1%) (p less than 0.001; Fisher's exact two-tail test). The two antibiotics were well tolerated during this study; the incidence of side effects reported was similar for azithromycin and cefaclor. Approximately two thirds of the side effects were mild. Only minor abnormalities in the screening laboratory tests were noted. This study shows that a 5-day course of once-daily azithromycin is as effective as a 10-day three times daily course of cefaclor in the treatment of patients with acute lower respiratory tract infections. JF - The American journal of medicine AU - Dark, D AD - Veterans Administration Medical Center, Medical Services Office, Kansas City, Missouri 64128. Y1 - 1991/09/12/ PY - 1991 DA - 1991 Sep 12 SP - 31S EP - 35S VL - 91 IS - 3A SN - 0002-9343, 0002-9343 KW - Erythromycin KW - 63937KV33D KW - Cefaclor KW - 69K7K19H4L KW - Azithromycin KW - 83905-01-5 KW - Abridged Index Medicus KW - Index Medicus KW - Moraxella (Branhamella) catarrhalis KW - Staphylococcal Infections -- drug therapy KW - Neisseriaceae Infections -- drug therapy KW - Sputum -- microbiology KW - Prospective Studies KW - Klebsiella Infections -- drug therapy KW - Humans KW - Haemophilus Infections -- drug therapy KW - Streptococcal Infections -- drug therapy KW - Bronchitis -- drug therapy KW - Pneumonia -- microbiology KW - Erythromycin -- analogs & derivatives KW - Cefaclor -- therapeutic use KW - Erythromycin -- therapeutic use KW - Erythromycin -- adverse effects KW - Bronchitis -- microbiology KW - Pneumonia -- drug therapy KW - Cefaclor -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72161401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Multicenter+evaluation+of+azithromycin+and+cefaclor+in+acute+lower+respiratory+tract+infections.&rft.au=Dark%2C+D&rft.aulast=Dark&rft.aufirst=D&rft.date=1991-09-12&rft.volume=91&rft.issue=3A&rft.spage=31S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-20 N1 - Date created - 1991-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of alterations in mental activity on the breathing pattern in healthy subjects. AN - 85244631; pmid-1892283 AB - The overall output from the respiratory centers is regulated by an automatic metabolic control system in the brainstem and by higher neural centers under direct voluntary control. An understanding of the constancy with which respiration is controlled can be obtained by measuring the breath-to-breath variability in breathing pattern. We hypothesized that different forms of mental activity would alter the variability of breathing pattern. To test this hypothesis, we measured breathing pattern on a breath-by-breath basis during resting wakefulness and during four conditions of altered mental activity. Measurements were obtained with a calibrated respiratory inductive plethysmograph, and variability was assessed by calculations of the coefficients of variation. We also examined the effect of the altered states of mental activity on the mean values of the breathing pattern components. We found that noxious stimulation increased the variability of all the breathing pattern indices, audiovisual stimulation tended to increase the variability of tidal volume (VT), and mental arithmetic had no effect. In addition, the variability of breathing pattern was increased during rapid eye movement sleep and decreased during Stage IV sleep. The variability of VT and expiratory time were greater than that of inspiratory time (TI) across the different states of mental activity. Significant correlations were observed between VT and TI and between VT and frequency (f) during Stage IV sleep. With regards to the mean values, mental arithmetic, audiovisual stimulation, and noxious stimulation all increased minute ventilation and mean inspiratory flow.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American Review of Respiratory Disease AU - Mador, M J AU - Tobin, M J AD - Division of Pulmonary Medicine, State University of New York, Veterans Administration Medical Center, Buffalo 14215. PY - 1991 SP - 481 EP - 487 VL - 144 IS - 3 Pt 1 SN - 0003-0805, 0003-0805 KW - Human KW - Respiration KW - Cognition KW - Mathematics KW - Sleep, REM KW - Photic Stimulation KW - Sleep Stages KW - Mental Processes KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Plethysmography KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Review+of+Respiratory+Disease&rft.atitle=Effect+of+alterations+in+mental+activity+on+the+breathing+pattern+in+healthy+subjects.&rft.au=Mador%2C+M+J%3BTobin%2C+M+J&rft.aulast=Mador&rft.aufirst=M&rft.date=1991-09-01&rft.volume=144&rft.issue=3+Pt+1&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+American+Review+of+Respiratory+Disease&rft.issn=00030805&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visual detectability gradients: effect of illiteracy. AN - 85210710; pmid-1781980 AB - When subjects are required to detect a target pattern presented simultaneously with a number of similar non-target patterns in a brief exposure, marked differences of target detectability are observed as a function of the spatial location of the target (Efron, Yund, & Nichols, 1987, 1990a, b, c; Yund, Efron & Nichols, 1990a, b, c). These differences in detectability as a function of retinal locus, referred to collectively as a "detectability gradient," have been attributed to a central serial processing mechanism, which scans the decaying neural representation of the image. There also is evidence suggesting that, at least in some circumstances, this gradient may be influenced by the direction in which subjects normally read (Heron, 1957; Mishkin & Forgays, 1952; Efron et al., 1987). The object of the present experiment was to determine whether the detectability gradient obtained with the non-linguistic stimuli used in our previous experiments would differ as a function of previous reading experience. The experiment was performed on a group of 60 illiterate subjects and on a socioeconomic-matched group of 60 literate subjects. While the overall accuracy of target detection was identical in the two groups, there were significant differences between the detectability gradients of the literate and illiterate subjects. The nature of these differences indicates that reading, or learning to read, causes the scanning mechanisms of literate subjects to adopt more consistent scan paths, from subject to subject, than they would have adopted without this reading experience. JF - Brain and Cognition AU - Ostrosky-Solis, F AU - Efron, R AU - Yund, E W AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1991 SP - 42 EP - 51 VL - 17 IS - 1 SN - 0278-2626, 0278-2626 KW - Analysis of Variance KW - Orientation KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Attention KW - Female KW - Male KW - Educational Status KW - Pattern Recognition, Visual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85210710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Visual+detectability+gradients%3A+effect+of+illiteracy.&rft.au=Ostrosky-Solis%2C+F%3BEfron%2C+R%3BYund%2C+E+W&rft.aulast=Ostrosky-Solis&rft.aufirst=F&rft.date=1991-09-01&rft.volume=17&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visual detectability gradients: effect of high-speed visual experience. AN - 85208049; pmid-1781981 AB - The detectability of a target pattern presented briefly with a number of similar nontarget patterns varies as a function of the spatial location of the target. Previous work attributes these detectability gradients to a visual search process--a non-eye movement serial scan--that examines a decaying neural representation of the image. (Heron, 1957; Efron, Yund, & Nichols, 1987, 1990a,b,c; Yund, Efron, & Nichols, 1990a,b,c). The results reported in the companion paper (Ostrosky-Solis, Efron, & Yund, 1991) indicated that literacy did not affect overall performance levels but did influence scanning behavior: "...reading, or learning to read, caused the scanning mechanisms of literate subjects to adopt more consistent scan paths, from subject to subject, than they would have adopted without this reading experience." The purpose of the present experiment was to determine the effect on this scanning mechanism, if any, of an entirely different type of visual experience--the high-speed visual processing required of tennis players. Unlike reading which requires the linguistic interpretation of a highly structured visual input, tennis skill requires rapid target detection and tracking in three-dimensional visual space as well as large scale visual-motor coordination. As in the previous experiments, subjects were required to detect a vertical stripe pattern among a number of similar non-target patterns. The experiment was performed on a group of 52 tennis players and on an age- and sex-matched group of 52 non-tennis players. The overall accuracy of target detection was greater among the tennis players than among the non-tennis players and, of more interest, there was a significant difference in the detectability gradients. The detection advantage of the tennis group seemed to reach its maximum in the first half of the scan and then to deteriorate as the scan proceeded. These results indicate that visual experience other than reading can affect the habitual activity of the scanning mechanism. JF - Brain and Cognition AU - Buckles, K M AU - Yund, E W AU - Efron, R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1991 SP - 52 EP - 63 VL - 17 IS - 1 SN - 0278-2626, 0278-2626 KW - Analysis of Variance KW - Orientation KW - Human KW - Motor Skills KW - Tennis KW - Pattern Recognition, Visual KW - Adult KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Attention KW - Time Factors KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Visual+detectability+gradients%3A+effect+of+high-speed+visual+experience.&rft.au=Buckles%2C+K+M%3BYund%2C+E+W%3BEfron%2C+R&rft.aulast=Buckles&rft.aufirst=K&rft.date=1991-09-01&rft.volume=17&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Psychiatric heterogeneity in antisocial alcoholics: relation to familial alcoholism. AN - 72504748; 1743013 AB - There is some indication that addicts who qualify for a diagnosis of antisocial personality disorder (ASP) do not comprise a homogeneous group with respect to psychopathology. This preliminary study attempted to determine the extent to which DSM-III diagnosed ASP alcoholics with alcoholism on both sides of their family could be differentiated with respect to childhood behavioral problems and additional adult psychopathology from ASP alcoholics with low degrees of familial alcoholism. Two groups of ASP alcoholic patients were compared: (1) 11 high familial (bilineal) alcoholics, and (2) 22 low familial (nonfamilial or unilineal) alcoholics. Few group differences were found in sociodemographic or alcohol-related characteristics, although the high familial group tended to be younger. However, the high familial alcoholism group tended to report more childhood antisocial behaviors and more childhood behavior problems overall. The high familial alcoholism group also reported more psychopathology on three of the 10 Minnesota Multiphasic Personality Inventory (MMPI) clinical scales, paranoia (P less than .05), schizophrenia (P less than .06), and masculine-feminine (P less than .025). Effect sizes for these three variables were in the moderate range. The group MMPI profile of the high familial alcoholism group was indicative of serious characterological disturbances, while that of the low familial alcoholism group was much more normal. The results of this preliminary study provided evidence suggesting that antisocial individuals with a high degree of familial alcoholism are more likely to manifest psychopathology than antisocial individuals with a lesser degree of familial alcoholism. JF - Comprehensive psychiatry AU - Alterman, A I AU - Gerstley, L J AU - Strohmetz, D B AU - McKay, J R AD - Veterans Administration Medical Center, Philadelphia, PA 19104. PY - 1991 SP - 423 EP - 430 VL - 32 IS - 5 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Personality Inventory -- statistics & numerical data KW - Risk Factors KW - Humans KW - Adult KW - Personality Development KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Personality Assessment -- statistics & numerical data KW - Antisocial Personality Disorder -- genetics KW - Antisocial Personality Disorder -- rehabilitation KW - Antisocial Personality Disorder -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72504748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Psychiatric+heterogeneity+in+antisocial+alcoholics%3A+relation+to+familial+alcoholism.&rft.au=Alterman%2C+A+I%3BGerstley%2C+L+J%3BStrohmetz%2C+D+B%3BMcKay%2C+J+R&rft.aulast=Alterman&rft.aufirst=A&rft.date=1991-09-01&rft.volume=32&rft.issue=5&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse. AN - 72096259; 1890839 AB - There is ample evidence to suggest that hematogenous metastasis may be related to the ability of tumor cells to promote aggregation of host platelets. Arachidonic acid metabolism in platelets and vessel walls may also contribute to the metastatic process. Several preliminary trials of platelet inhibitory agents have been performed. Ketoconazole (inhibitor of lipoxygenase and thromboxane synthetase), verapamil (calcium antagonist), forskolin (stimulator of platelet adenylate cyclase), and indomethacin (inhibitor of cyclooxygenase) were examined, alone and in combination, to investigate their effects on platelet aggregation and on hepatic metastases from human pancreatic tumor cells (RWP-2) in nude mice. The tumor cells were injected intrasplenically, and the animals were divided into control, single-drug and combination treatment groups. The agents were administered intraperitoneally 1 hr before and every 24 hr after the tumor cell injections for 6 days. Statistically significant differences were observed between the control and single-treatment groups on the reduction of liver tumor nodules (range P less than 0.001-0.032) and in the liver surface areas occupied by tumor (range P less than 0.001-0.013). Furthermore, when these agents were combined, similar reductions in liver tumor nodules were noted (range P less than 0.001-0.008), while even greater inhibitory effects were seen in the liver surface areas occupied by tumor (P less than 0.001) compared with the single-treatment groups. Also, the combination studies strongly inhibited RWP-2-induced platelet aggregation in human platelet-rich plasma. JF - Journal of surgical oncology AU - Tzanakakis, G N AU - Agarwal, K C AU - Veronikis, D K AU - Vezeridis, M P AD - Surgical Service, Veterans Administration Medical Center, Providence, RI 02908. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 45 EP - 50 VL - 48 IS - 1 SN - 0022-4790, 0022-4790 KW - Platelet Aggregation Inhibitors KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - Verapamil KW - CJ0O37KU29 KW - Ketoconazole KW - R9400W927I KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Drug Interactions KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Mice, Nude KW - Mice KW - Verapamil -- pharmacology KW - Ketoconazole -- pharmacology KW - Indomethacin -- pharmacology KW - Pancreatic Neoplasms -- pathology KW - Adenocarcinoma -- secondary KW - Platelet Aggregation Inhibitors -- pharmacology KW - Liver Neoplasms -- secondary KW - Platelet Aggregation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72096259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Effects+of+antiplatelet+agents+alone+or+in+combinations+on+platelet+aggregation+and+on+liver+metastases+from+a+human+pancreatic+adenocarcinoma+in+the+nude+mouse.&rft.au=Tzanakakis%2C+G+N%3BAgarwal%2C+K+C%3BVeronikis%2C+D+K%3BVezeridis%2C+M+P&rft.aulast=Tzanakakis&rft.aufirst=G&rft.date=1991-09-01&rft.volume=48&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-16 N1 - Date created - 1991-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Screening for colon malignancy with colonoscopy. AN - 85224306; pmid-1858758 AB - Screening of asymptomatic individuals for colon malignancy has been advocated for the past 20 yr in the hopes of reducing colon cancer mortality. Although sigmoidoscopy is an important element of current screening recommendations, the sensitivity of this test in asymptomatic subjects has never been studied. The purpose of this study was to determine the prevalence and location of polyps and cancers in an asymptomatic population by performing full colonoscopy. We wished to assess the sensitivity of screening flexible sigmoidoscopy to 60 cm by determining how many patients with adenomas or cancer had "index" adenomatous polyps in the distal 60 cm. One hundred five healthy male outpatients, over 50 yr old, with negative examinations for occult blood in stools and no prior history of colon pathology, had full colonoscopy. Careful examination of the distal 60 cm was performed, followed by a full colon examination to the cecum. Forty-three patients (41%) had adenomatous polyps, and only 19 of these patients had an index adenomatous polyp in the distal 60 cm. Therefore, the sensitivity of sigmoidoscopy was 44%. The prevalence of adenomas increased with age. Patients were assigned to one of three groups based on the findings in the distal 60 cm. Group 1 (n = 65) had no polyps in the distal 60 cm, but 18 of these patients (28%) had adenomatous polyps in the proximal colon. Among 21 patients with only hyperplastic polyps in the distal 60 cm (group 2), six patients (29%) had proximal adenomas. In group 3, eight of 19 patients (42%) with adenomas in the distal 60 cm also had proximal adenomatous polyps. We conclude that adenomatous polyps are common in asymptomatic men who have negative tests for fecal occult blood. Sigmoidoscopy to 60 cm had a sensitivity of only 44% in this patient population, suggesting that this is an insensitive test for the detection of patients with adenomatous polyps. JF - The American Journal of Gastroenterology AU - Lieberman, D A AU - Smith, F W AD - Veterans Administration Medical Center, Portland, Oregon. PY - 1991 SP - 946 EP - 951 VL - 86 IS - 8 SN - 0002-9270, 0002-9270 KW - Mass Screening KW - Human KW - Risk Factors KW - Colonic Polyps KW - Aged KW - Middle Age KW - Male KW - Prevalence KW - Sigmoidoscopy KW - Colonoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Screening+for+colon+malignancy+with+colonoscopy.&rft.au=Lieberman%2C+D+A%3BSmith%2C+F+W&rft.aulast=Lieberman&rft.aufirst=D&rft.date=1991-08-01&rft.volume=86&rft.issue=8&rft.spage=946&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog. AN - 80736574; 1867522 AB - The efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in each group received lovastatin, and the remaining six received only distilled water. All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterol-fed/lovastatin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease. JF - Annals of surgery AU - Saunders, K D AU - Cates, J A AU - Abedin, M Z AU - Rege, S AU - Festekdjian, S F AU - Howard, W AU - Roslyn, J J AD - Research and Surgical Services, Sepulveda Veterans Administration Medical Center, California. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 149 EP - 154 VL - 214 IS - 2 SN - 0003-4932, 0003-4932 KW - Cholesterol, Dietary KW - 0 KW - Cholesterol, HDL KW - Cholesterol, LDL KW - Cholesterol KW - 97C5T2UQ7J KW - Lovastatin KW - 9LHU78OQFD KW - Abridged Index Medicus KW - Index Medicus KW - Cholesterol, LDL -- blood KW - Animals KW - Sciuridae KW - Gallbladder -- metabolism KW - Cholesterol, HDL -- blood KW - Liver -- metabolism KW - Cholesterol -- analysis KW - Bile -- metabolism KW - Cholesterol, Dietary -- adverse effects KW - Male KW - Cholelithiasis -- chemistry KW - Cholelithiasis -- chemically induced KW - Lovastatin -- pharmacology KW - Cholelithiasis -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80736574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgery&rft.atitle=Lovastatin+inhibits+gallstone+formation+in+the+cholesterol-fed+prairie+dog.&rft.au=Saunders%2C+K+D%3BCates%2C+J+A%3BAbedin%2C+M+Z%3BRege%2C+S%3BFestekdjian%2C+S+F%3BHoward%2C+W%3BRoslyn%2C+J+J&rft.aulast=Saunders&rft.aufirst=K&rft.date=1991-08-01&rft.volume=214&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgery&rft.issn=00034932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-12 N1 - Date created - 1991-09-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1972 Jun;51(6):1495-503 [5063380] Am J Clin Pathol. 1966 Mar;45(3):290-6 [5932858] Gastroenterology. 1974 May;66(5):1036-45 [4826988] J Lipid Res. 1978 Nov;19(8):945-55 [731129] Lab Anim Sci. 1978 Aug;28(4):428-32 [100653] Gastroenterology. 1980 Jun;78(6):1412-8 [7372061] Hepatology. 1982 Nov-Dec;2(6):804-10 [7141392] Ann Intern Med. 1981 Sep;95(3):257-82 [7023307] J Lipid Res. 1983 Apr;24(4):461-8 [6854153] Gastroenterology. 1990 Jun;98(6):1572-6 [2338194] J Clin Invest. 1985 Nov;76(5):1773-81 [4056052] Pharmacotherapy. 1987;7(6):198-210 [3328165] N Engl J Med. 1988 Feb 18;318(7):393-7 [3340116] Ann Intern Med. 1987 Nov;107(5):609-15 [3662274] Hepatology. 1988 Sep-Oct;8(5):1147-50 [3047037] Ann Surg. 1988 Sep;208(3):274-8 [3421753] J Biol Chem. 1957 Mar;225(1):177-83 [13416228] J Biochem. 1964 Nov;56:424-31 [14235501] J Clin Invest. 1968 May;47(5):1043-52 [5645851] Gastroenterology. 1974 Apr;66(4):565-73 [4821079] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression. AN - 80729820; 1867323 AB - Cultured glomerular mesangial cells (MC) respond to low concentrations of bacterial endotoxin (ET) by secreting prostaglandins and interleukin-1. To evaluate further the nature of ET-induced mesangial cell activation, the authors evaluated the effects of this agent on MC morphology and cytoskeletal organization. Bacterial ET, in concentrations as low as I ng/ml, induced reversible membrane ruffling, cellular rounding, and extension of many filopodia and lamellopodia. Augmented fluid-phase pinocytosis occurred in parallel, as determined by transmission electron microscopy and tritiated sucrose uptake. These cellular morphologic and functional changes were associated with an extensive, but reversible, depolymerization of actin microfilaments. Actin gene expression was also modified by ET. At 4 to 6 hours after ET exposure, Northern blot analysis showed a twofold to fourfold increase in actin mRNA levels. In situ hybridizations of ET-stimulated cells at the light and electron microscopic levels demonstrated a markedly asymmetric distribution of actin mRNA, which was localized in the cellular periphery at filopodial and lamellopodial extensions, presumably sites of new actin protein synthesis. It is concluded that ET effects on MC are distinct from the nonspecific lytic or 'toxic' actions described for other cell types. Endotoxin induces a global activation of this cell type associated with major changes in membrane structure, cytoskeletal organization, and gene expression, which resemble in many respects the responses to peptide mitogens. JF - The American journal of pathology AU - Bursten, S L AU - Stevenson, F AU - Torrano, F AU - Lovett, D H AD - Department of Medicine, Seattle Veterans Administration Medical Center, Washington. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 371 EP - 382 VL - 139 IS - 2 SN - 0002-9440, 0002-9440 KW - Actins KW - 0 KW - Endotoxins KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Actins -- genetics KW - Pinocytosis -- drug effects KW - Male KW - Gene Expression -- drug effects KW - Glomerular Mesangium -- cytology KW - Glomerular Mesangium -- drug effects KW - Escherichia coli KW - Cytoskeleton -- ultrastructure KW - Cytoskeleton -- physiology KW - Endotoxins -- pharmacology KW - Cytoskeleton -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80729820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Mesangial+cell+activation+by+bacterial+endotoxin.+Induction+of+rapid+cytoskeletal+reorganization+and+gene+expression.&rft.au=Bursten%2C+S+L%3BStevenson%2C+F%3BTorrano%2C+F%3BLovett%2C+D+H&rft.aulast=Bursten&rft.aufirst=S&rft.date=1991-08-01&rft.volume=139&rft.issue=2&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-06 N1 - Date created - 1991-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 1963 Oct;43(4):555-78 [19971026] J Cell Biol. 1979 Oct;83(1):82-90 [315944] J Biol Chem. 1986 Dec 5;261(34):16141-7 [2946680] J Cell Biol. 1985 Apr;100(4):1031-40 [3920222] J Cell Biol. 1986 Mar;102(3):697-702 [3005336] J Clin Invest. 1988 Nov;82(5):1479-88 [3263392] Biochem J. 1987 Nov 1;247(3):613-9 [3122731] Am J Pathol. 1988 Dec;133(3):472-84 [3059803] Kidney Int. 1989 May;35(5):1111-8 [2549293] J Cell Biol. 1989 Jun;108(6):2343-53 [2738094] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7476-80 [6334309] Nature. 1984 Oct 4-10;311(5985):433-8 [6090941] Am J Pathol. 1986 Oct;125(1):130-40 [3535527] Kidney Int. 1986 Oct;30(4):474-80 [3537451] Proc Natl Acad Sci U S A. 1987 Jun;84(12):4122-5 [3473496] Anat Embryol (Berl). 1987;176(3):373-86 [3631536] Nature. 1986 Sep 11-17;323(6084):171-3 [3748188] Biochim Biophys Acta. 1985;780(3):197-212 [3896312] Kidney Int. 1990 May;37(5):1281-5 [2345426] Exp Cell Res. 1984 Jul;153(1):186-97 [6376151] J Cell Biol. 1984 May;98(5):1662-71 [6327718] J Cell Biol. 1980 Aug;86(2):634-40 [7400219] J Cell Biol. 1986 Sep;103(3):1021-31 [3017994] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bronchial epithelial cells release monocyte chemotactic activity in response to smoke and endotoxin. AN - 80715686; 1861084 AB - An increase in mononuclear phagocytes occurs within the airways during airway inflammation. Bronchial epithelial cells could release monocyte chemotactic activity and contribute to this increase. To test this hypothesis, bovine bronchial epithelial cells were isolated and maintained in culture. Bronchial epithelial cell culture supernatant fluids were evaluated for monocyte chemotactic activity. Epithelial cell culture supernatant fluids attracted significantly greater numbers of monocytes compared to media alone and the number of monocytes attracted increased in a time dependent manner. Endotoxin and smoke extract induced a dose and time dependent release of monocyte chemotactic activity compared with cells cultured in media (52.5 +/- 2.6 (endotoxin), 30.5 +/- 2.3 (smoke) vs 20.5 +/- 2.2 cells/high power field (HPF) p less than 0.001). The released activity was chemotactic by checkerboard analysis. Stimulation of the epithelial cells by opsonized zymosan, calcium ionophore (A23187), and PMA also resulted in an increase in monocyte chemotactic activity (p less than 0.01). Because the release of activity was blocked by the lipoxygenase inhibitors, nordihydroguaiaretic acid and diethycarbamazine, epithelial cell monolayers were cultured with 3 microCi [3H]arachidonic acid for 24 h and then exposed to A23187, PMA, or both stimuli, for 4, 8, and 24 h. Analysis of the released 3H activity was performed with reverse-phase HPLC and revealed that the major lipoxygenase product was leukotriene B4. These data suggest that monocytes may be recruited into airways in response to chemotactic factors released by bronchial epithelial cells. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Koyama, S AU - Rennard, S I AU - Leikauf, G D AU - Robbins, R A AD - Research Service, Omaha Veterans Administration Medical Center, NE. Y1 - 1991/08/01/ PY - 1991 DA - 1991 Aug 01 SP - 972 EP - 979 VL - 147 IS - 3 SN - 0022-1767, 0022-1767 KW - Chemotactic Factors KW - 0 KW - Endotoxins KW - Smoke KW - Calcimycin KW - 37H9VM9WZL KW - Masoprocol KW - 7BO8G1BYQU KW - Zymosan KW - 9010-72-4 KW - Cycloheximide KW - 98600C0908 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Diethylcarbamazine KW - V867Q8X3ZD KW - Hydrocortisone KW - WI4X0X7BPJ KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Zymosan -- pharmacology KW - Dose-Response Relationship, Drug KW - Calcimycin -- pharmacology KW - Chromatography, High Pressure Liquid KW - Indomethacin -- pharmacology KW - Hydrocortisone -- pharmacology KW - Cattle KW - Chromatography, Gel KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes KW - Diethylcarbamazine -- pharmacology KW - Masoprocol -- pharmacology KW - Smoke -- adverse effects KW - Chemotaxis, Leukocyte -- drug effects KW - Endotoxins -- adverse effects KW - Bronchi -- metabolism KW - Bronchi -- drug effects KW - Chemotactic Factors -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80715686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Bronchial+epithelial+cells+release+monocyte+chemotactic+activity+in+response+to+smoke+and+endotoxin.&rft.au=Koyama%2C+S%3BRennard%2C+S+I%3BLeikauf%2C+G+D%3BRobbins%2C+R+A&rft.aulast=Koyama&rft.aufirst=S&rft.date=1991-08-01&rft.volume=147&rft.issue=3&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative efficacy and safety of bepridil and diltiazem in chronic stable angina pectoris refractory to diltiazem. The Bepridil Collaborative Study Group. AN - 80710160; 1858672 AB - The efficacy and safety of bepridil hydrochloride (200 to 400 mg/day) were evaluated in patients with chronic stable angina refractory to maximal tolerated doses of diltiazem (median 360 mg/day) in a randomized, multicenter, double-blind, parallel study. Baseline diltiazem data were obtained during a 2-week period, after which 86 patients were randomized to bepridil (n = 46) or diltiazem (n = 40). Angina frequency, nitroglycerin consumption and ischemic manifestations induced by exercise treadmill testing were evaluated over 8 weeks. Bepridil significantly (p less than 0.05) increased time to angina onset, time to 1 and 2 mm of ST-segment depression, total exercise time and total work over baseline values. Changes in time to angina onset and time to 1 mm of ST-segment depression were significantly (p less than 0.05) greater for bepridil than for diltiazem. Angina frequency and nitroglycerin consumption did not differ significantly between groups. Compared with baseline, bepridil significantly (p less than 0.001) decreased heart rate (mean 4 beats/min) and prolonged QTc (mean 35 ms). The most frequent adverse effects in both groups were nausea, asthenia, dizziness, headache and diarrhea. Four patients taking bepridil and 1 taking diltiazem withdrew from the study because of adverse reactions. No sudden deaths, myocardial infarctions or instances of sustained ventricular tachycardia or torsades de pointes occurred in either group. The data indicate that bepridil provided safe and effective antianginal and antiischemic therapy in patients with chronic stable angina who exhibited less than optimal response to maximal tolerated doses of diltiazem. JF - The American journal of cardiology AU - Singh, B N AD - Department of Cardiology, Veterans Administration Medical Center of West Los Angeles, California. Y1 - 1991/08/01/ PY - 1991 DA - 1991 Aug 01 SP - 306 EP - 312 VL - 68 IS - 4 SN - 0002-9149, 0002-9149 KW - Bepridil KW - 755BO701MA KW - Diltiazem KW - EE92BBP03H KW - Abridged Index Medicus KW - Index Medicus KW - Drug Tolerance KW - Heart Rate -- drug effects KW - Exercise Test -- drug effects KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Diltiazem -- pharmacology KW - Bepridil -- pharmacology KW - Angina Pectoris -- drug therapy KW - Bepridil -- therapeutic use KW - Bepridil -- adverse effects KW - Diltiazem -- therapeutic use KW - Diltiazem -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80710160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Comparative+efficacy+and+safety+of+bepridil+and+diltiazem+in+chronic+stable+angina+pectoris+refractory+to+diltiazem.+The+Bepridil+Collaborative+Study+Group.&rft.au=Singh%2C+B+N&rft.aulast=Singh&rft.aufirst=B&rft.date=1991-08-01&rft.volume=68&rft.issue=4&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of lithium on function and growth of thyroid cells in vitro. AN - 80697319; 1649747 AB - Lithium has been reported to alter thyroid function and cause goiter in some patients. To explain the mechanism of lithium action in the thyroid gland, we studied the effect of lithium on thyroid function and cell growth in FRTL-5 rat thyroid cells and on de novo thyroid hormone formation in primary cultures of porcine thyroid follicles. TSH-induced iodide uptake was suppressed at 2 mM lithium in both FRTL-5 cells and porcine follicles. In porcine thyroid follicles, iodide uptake stimulated by 8-bromo-cAMP, iodine organification, and de novo thyroid hormone formation were also reduced by lithium; however, 2 mM lithium did not inhibit TSH-induced cAMP production. In FRTL-5 cells, lithium also inhibited forskolin-stimulated iodide uptake. These results suggested that lithium exerts its effect at a step involving cAMP signal transduction rather than inhibiting cAMP production. In both FRTL-5 thyroid cells and porcine follicles, lithium enhanced cell growth in basal states (lacking TSH) and with TSH treatment. In porcine thyroid cells, the protein kinase C activator, tetradecanoyl phorbol-13-acetate, increased cell growth, and lithium had an additive effect with tetradecanoyl phorbol-13-acetate on cell growth. To examine the possibility that the action of lithium was mediated by the protein kinase C pathway, porcine cells were incubated with lithium and H7, a selective protein kinase C inhibitor. Lithium-induced cell growth was suppressed to the basal level by H7. These results suggest that lithium exerts its growth-promoting effect through the protein kinase C system. JF - Endocrinology AU - Urabe, M AU - Hershman, J M AU - Pang, X P AU - Murakami, S AU - Sugawara, M AD - Endocrine Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 807 EP - 814 VL - 129 IS - 2 SN - 0013-7227, 0013-7227 KW - Iodides KW - 0 KW - Isoquinolines KW - Piperazines KW - Triiodothyronine KW - 06LU7C9H1V KW - Colforsin KW - 1F7A44V6OU KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Thyrotropin KW - 9002-71-5 KW - Lithium KW - 9FN79X2M3F KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Cyclic AMP -- biosynthesis KW - Triiodothyronine -- physiology KW - Cell Division -- drug effects KW - Piperazines -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Rats KW - Protein Kinase C -- metabolism KW - Isoquinolines -- pharmacology KW - Colforsin -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Thyrotropin -- pharmacology KW - Iodides -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Thyroid Gland -- physiology KW - Thyroid Gland -- drug effects KW - Thyroid Gland -- cytology KW - Lithium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80697319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Effect+of+lithium+on+function+and+growth+of+thyroid+cells+in+vitro.&rft.au=Urabe%2C+M%3BHershman%2C+J+M%3BPang%2C+X+P%3BMurakami%2C+S%3BSugawara%2C+M&rft.aulast=Urabe&rft.aufirst=M&rft.date=1991-08-01&rft.volume=129&rft.issue=2&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of cyclophosphamide, doxorubicin, and vincristine with an alternating regimen of methotrexate, etoposide, and cisplatin/cyclophosphamide, doxorubicin, and vincristine in the treatment of extensive-disease small-cell lung carcinoma: a Mid-Atlantic Oncology Program study. AN - 80686798; 1649265 AB - An alternating regimen for the treatment of extensive-disease small-cell lung cancer (SCLC) was compared with standard treatment with cyclophosphamide, doxorubicin, and vincristine (CAV) in 170 patients. Overall severity of toxicity was similar in both arms, with four toxic deaths in each arm (4.7%). Response results were also similar, with 54% complete and partial responses with the standard regimen and 53% complete and partial responses with the alternating regimen. Median survival time was 6.9 months with the standard regimen and 9.2 months with the alternating regimen (P = .078). The 2-year survival rate was 1.2% for the standard regimen and 4.7% for the alternating regimen. Survival benefit for treatment with the alternating regimen reached statistical significance only in those subsets of patients with poorer prognosis (male sex, performance status 3, liver metastases, bone marrow metastases, and oat cell histologic subtype). JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Wampler, G L AU - Heim, W J AU - Ellison, N M AU - Ahlgren, J D AU - Fryer, J G AD - Richmond Veterans Administration Medical Center, VA. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 1438 EP - 1445 VL - 9 IS - 8 SN - 0732-183X, 0732-183X KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Prognosis KW - Doxorubicin -- administration & dosage KW - Cisplatin -- administration & dosage KW - Etoposide -- administration & dosage KW - Survival Rate KW - Middle Aged KW - Methotrexate -- administration & dosage KW - Female KW - Male KW - Proportional Hazards Models KW - Carcinoma, Small Cell -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80686798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Comparison+of+cyclophosphamide%2C+doxorubicin%2C+and+vincristine+with+an+alternating+regimen+of+methotrexate%2C+etoposide%2C+and+cisplatin%2Fcyclophosphamide%2C+doxorubicin%2C+and+vincristine+in+the+treatment+of+extensive-disease+small-cell+lung+carcinoma%3A+a+Mid-Atlantic+Oncology+Program+study.&rft.au=Wampler%2C+G+L%3BHeim%2C+W+J%3BEllison%2C+N+M%3BAhlgren%2C+J+D%3BFryer%2C+J+G&rft.aulast=Wampler&rft.aufirst=G&rft.date=1991-08-01&rft.volume=9&rft.issue=8&rft.spage=1438&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-22 N1 - Date created - 1991-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium antagonists and renal hemodynamics: implications for renal protection. AN - 72169979; 1932641 AB - During the past decade, attention has focused on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal effects. Calcium antagonists do not affect the vasodilated isolated perfused kidney, but they do dramatically alter the response of this preparation to vasoconstrictor agents. Our recent studies with the isolated perfused hydronephrotic rat kidney model, which permits visualization of afferent and efferent arterioles, have demonstrated that the augmentation of glomerular filtration rate observed in the isolated perfused kidney is attributable to preferential vasodilation of preglomerular vessels. Although the clinical implications of such observations have not been fully delineated, the results of recent studies indicate that calcium antagonists exert salutary effects on renal function in patients with impaired renal hemodynamics. Such disorders include radiocontrast-induced nephrotoxicity and transplant-associated acute renal insufficiency. It is apparent, however, that the effects of calcium antagonists on renal blood flow commend their use in the management of essential hypertension. JF - Journal of the American Society of Nephrology : JASN AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - S30 EP - S36 VL - 2 IS - 2 Suppl 1 SN - 1046-6673, 1046-6673 KW - Calcium Channel Blockers KW - 0 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Glomerular Filtration Rate KW - Hypertension, Renal -- prevention & control KW - Hypertension, Renal -- physiopathology KW - Humans KW - Disease Models, Animal KW - Kidney Diseases -- physiopathology KW - Calcium Channel Blockers -- pharmacology KW - Kidney Diseases -- prevention & control KW - Kidney -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72169979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Calcium+antagonists+and+renal+hemodynamics%3A+implications+for+renal+protection.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=1991-08-01&rft.volume=2&rft.issue=2+Suppl+1&rft.spage=S30&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Medical complications of spinal cord disease. AN - 72141142; 1921958 AB - Spinal cord injury increases the risk of many life-threatening medical problems, including respiratory failure, pulmonary embolism, and renal failure. Respiratory failure results from paralysis of muscles of inspiration (which impairs oxygen transport to alveoli) and of expiration (which impairs cough and predisposes to pneumonia and atelectasis). Respiratory failure in patients with spinal cord injury can be prevented by proper positioning of the patient, training of ventilatory muscles, pulmonary toilet, and aggressive use of antibiotics and bronchodilators. When respiratory failure occurs, it can be managed by administration of oxygen, intubation, and mechanical ventilation, and in instances of paralysis of the diaphragm, by diaphragmatic pacing. The risk of deep vein thrombosis and pulmonary embolism in acute spinal cord disease is increased by the immobilization of the patient and abnormalities in clotting factors. Thrombotic disease in spinal cord disease can be prevented by intermittent calf compression and heparinization. If pulmonary embolism develops, the patient should be started on a regimen of warfarin for at least 3 months. If anticoagulation is contraindicated, a Greenfield filter can be placed. However, concurrent use of quad cough places the patient at increased risk for complications from the Greenfield filter. Chronic pyelonephritis and systemic amyloidosis are the most common causes of renal failure in the patient with spinal cord disease. Renal failure can be prevented by maintaining a low postvoid residual volume, avoidance of indwelling catheters, use of medications that are not nephrotoxic, and rapid treatment of infection. Hemodialysis and peritoneal dialysis can extend the life of the patient with spinal cord disease in whom renal failure develops, and successful use of renal transplantation has recently been reported. JF - Neurologic clinics AU - Schmitt, J AU - Midha, M AU - McKenzie, N AD - Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA 23249. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 779 EP - 795 VL - 9 IS - 3 SN - 0733-8619, 0733-8619 KW - Index Medicus KW - Lung Diseases -- etiology KW - Humans KW - Kidney Diseases -- etiology KW - Vascular Diseases -- etiology KW - Spinal Cord Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72141142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurologic+clinics&rft.atitle=Medical+complications+of+spinal+cord+disease.&rft.au=Schmitt%2C+J%3BMidha%2C+M%3BMcKenzie%2C+N&rft.aulast=Schmitt&rft.aufirst=J&rft.date=1991-08-01&rft.volume=9&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Neurologic+clinics&rft.issn=07338619&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis. AN - 72063387; 1715446 AB - Proliferation of mesangial cells and expansion of mesangial matrix are common histologic features of proliferative glomerular disease, a frequent cause of renal failure. Proliferation of glomerular mesangial cells occurs in response to platelet-derived growth factor (PDGF), and these cells release PDGF and express PDGF A and B chain mRNAs. However, all studies relating PDGF to potential changes in glomerular structure and function to date have been performed in vitro. To explore the role of PDGF in proliferative glomerulonephritides, we studied the expression of PDGF in vivo in two animal models of IgA nephropathy with different histologic patterns of glomerular injury: either predominant mesangial proliferation or expansion of mesangial matrix. Increased expression of PDGF and PDGF B-chain mRNA in whole kidneys from diseased mice was demonstrated by immunohistochemical techniques and by solution hybridization assay, respectively. Immunohistochemically, PDGF was localized primarily within the mesangial area of glomeruli and to a much lower extent in interstitium. The increased PDGF expression correlated with the degree of hypercellularity and clinical features of the disease. In addition, PDGF expression was increased in some forms of human glomerulonephritis, characterized by mesangial proliferation. These findings suggest that PDGF may be a major contributor to mesangial cell proliferation seen in proliferative glomerulonephritides. JF - Laboratory investigation; a journal of technical methods and pathology AU - Gesualdo, L AU - Pinzani, M AU - Floriano, J J AU - Hassan, M O AU - Nagy, N U AU - Schena, F P AU - Emancipator, S N AU - Abboud, H E AD - Institute of Pathology, Veterans Administration Hospital, Case Western Reserve University, Cleveland, Ohio. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 160 EP - 167 VL - 65 IS - 2 SN - 0023-6837, 0023-6837 KW - Dextrans KW - 0 KW - Platelet-Derived Growth Factor KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Humans KW - RNA, Messenger -- analysis KW - Mice KW - Nucleic Acid Hybridization KW - Fluorescent Antibody Technique KW - Immunoenzyme Techniques KW - Platelet-Derived Growth Factor -- metabolism KW - Kidney -- metabolism KW - Kidney -- pathology KW - Glomerulonephritis, IGA -- metabolism KW - Glomerulonephritis, IGA -- chemically induced KW - Platelet-Derived Growth Factor -- genetics KW - Glomerulonephritis, IGA -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72063387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Platelet-derived+growth+factor+expression+in+mesangial+proliferative+glomerulonephritis.&rft.au=Gesualdo%2C+L%3BPinzani%2C+M%3BFloriano%2C+J+J%3BHassan%2C+M+O%3BNagy%2C+N+U%3BSchena%2C+F+P%3BEmancipator%2C+S+N%3BAbboud%2C+H+E&rft.aulast=Gesualdo&rft.aufirst=L&rft.date=1991-08-01&rft.volume=65&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-27 N1 - Date created - 1991-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of withdrawal of typical and atypical antipsychotic drugs: a case study. AN - 72030872; 1869497 AB - Haloperidol and clozapine were rapidly withdrawn from a schizophrenic patient on separate occasions several months apart. Mental status changes and fluctuations in involuntary movements were carefully observed under both conditions. Although little change in either mental status or involuntary movements was observed within the 3 weeks following the withdrawal of haloperidol, marked deterioration in mental status and involuntary movements occurred within 1 week of withdrawal of clozapine. Implications of this differential response to withdrawal of antipsychotic medications are discussed. JF - The Journal of clinical psychiatry AU - Alphs, L D AU - Lee, H S AD - Cleveland Veterans Administration Medical Center, Ohio 48101. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 346 EP - 348 VL - 52 IS - 8 SN - 0160-6689, 0160-6689 KW - Clozapine KW - J60AR2IKIC KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Acute Disease KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Humans KW - Adult KW - Schizophrenic Psychology KW - Psychoses, Substance-Induced -- psychology KW - Psychoses, Substance-Induced -- etiology KW - Male KW - Ambulatory Care KW - Haloperidol -- adverse effects KW - Haloperidol -- therapeutic use KW - Substance Withdrawal Syndrome -- etiology KW - Clozapine -- therapeutic use KW - Schizophrenia -- drug therapy KW - Schizophrenia -- chemically induced KW - Clozapine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72030872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Comparison+of+withdrawal+of+typical+and+atypical+antipsychotic+drugs%3A+a+case+study.&rft.au=Alphs%2C+L+D%3BLee%2C+H+S&rft.aulast=Alphs&rft.aufirst=L&rft.date=1991-08-01&rft.volume=52&rft.issue=8&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group. AN - 72112324; 1655072 AB - In order to determine the effect of an anticholinergic agent on mood and sleep, scopolamine (0.4 mg IM) was administered before bedtime for three consecutive nights to 10 depressed patients (8 with a history of alcohol abuse) and 10 normal comparison subjects. The patients had a small, statistically significant antidepressant response on the second morning of treatment. Scopolamine inhibited rapid eye movement (REM) sleep and prolonged REM latency equally in depressed patients and the normal comparison group. Partial tolerance to the REM inhibiting effect of scopolamine developed between the first and third night of treatment. A REM rebound occurred during recovery nights. These results are consistent with concepts relating central cholinergic mechanisms to the control of REM sleep. Compared with controls, patients showed a greater increase in Stage 2 and Stage 2% and a lesser and increase in Delta (Stage 3 and 4) sleep % and Stage 4% on the first night of treatment. Further, well-controlled studies are needed to determine whether anticholinergic drugs possess clinically significant antidepressant effects. JF - Biological psychiatry AU - Gillin, J C AU - Sutton, L AU - Ruiz, C AU - Darko, D AU - Golshan, S AU - Risch, S C AU - Janowsky, D AD - Department of Psychiatry, San Diego Veterans Administration Medical Center, CA. Y1 - 1991/07/15/ PY - 1991 DA - 1991 Jul 15 SP - 157 EP - 169 VL - 30 IS - 2 SN - 0006-3223, 0006-3223 KW - Receptors, Cholinergic KW - 0 KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Index Medicus KW - Receptors, Cholinergic -- drug effects KW - Personality Tests KW - Synaptic Transmission -- drug effects KW - Humans KW - Adult KW - Electroencephalography -- drug effects KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Reaction Time -- drug effects KW - Scopolamine Hydrobromide -- administration & dosage KW - Affect -- drug effects KW - Depressive Disorder -- psychology KW - Depressive Disorder -- drug therapy KW - Sleep Stages -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72112324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=The+effects+of+scopolamine+on+sleep+and+mood+in+depressed+patients+with+a+history+of+alcoholism+and+a+normal+comparison+group.&rft.au=Gillin%2C+J+C%3BSutton%2C+L%3BRuiz%2C+C%3BDarko%2C+D%3BGolshan%2C+S%3BRisch%2C+S+C%3BJanowsky%2C+D&rft.aulast=Gillin&rft.aufirst=J&rft.date=1991-07-15&rft.volume=30&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fulminant hepatic failure due to acute hepatitis B and delta co-infection: probable bloodborne transmission associated with a spring-loaded fingerstick device. AN - 85224137; pmid-2058635 AB - Fulminant hepatic failure (FHF) due to acute hepatitis B and delta co-infection occurred in a 74-yr-old female, who eventually died. There was no clear-cut epidemiology other than probable bloodborne transmission from a contaminated spring-loaded fingerstick device used for glucose determination, in an outpatient facility. This unusual mode of transmission reiterates the importance of using sterile cleansing and disposal procedures anytime there is a possibility of contamination with blood. JF - The American Journal of Gastroenterology AU - Mendez, L AU - Reddy, K R AU - Di Prima R A AU - Jeffers, L J AU - Schiff, E R AD - Veterans Administration Medical Center, Miami, Florida. PY - 1991 SP - 895 EP - 897 VL - 86 IS - 7 SN - 0002-9270, 0002-9270 KW - Hepatic Encephalopathy KW - Equipment Contamination KW - Human KW - Hepatitis B KW - Aged KW - Blood Specimen Collection KW - Case Report KW - Hepatitis D KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Fulminant+hepatic+failure+due+to+acute+hepatitis+B+and+delta+co-infection%3A+probable+bloodborne+transmission+associated+with+a+spring-loaded+fingerstick+device.&rft.au=Mendez%2C+L%3BReddy%2C+K+R%3BDi+Prima+R+A%3BJeffers%2C+L+J%3BSchiff%2C+E+R&rft.aulast=Mendez&rft.aufirst=L&rft.date=1991-07-01&rft.volume=86&rft.issue=7&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of reference microphone location and loudspeaker azimuth on probe tube microphone measurements. AN - 85148440; pmid-1768884 AB - The effects of loudspeaker azimuth and reference microphone location on probe tube microphone measures were assessed. The real ear unaided response (REUR), real ear aided response (REAR), and real ear insertion response (REIR) were obtained on a KEMAR. Aided measures were obtained with both a behind-the-ear and an in-the-ear hearing aid. All three measurements were affected by changes in the loudspeaker azimuth and reference microphone location. Responses obtained with a 90 degree loudspeaker azimuth or with the reference microphone located at-the-ear revealed greater disparity than those obtained under other conditions. Most of the differences occurred at frequencies above 2000 Hz, with measurements utilizing the behind-the-ear hearing aid showing greater dispersion. These results suggest that the location of the loudspeaker and the reference microphone are important variables when utilizing probe tube microphone measurements. JF - Journal of the American Academy of Audiology AU - Ickes, M A AU - Hawkins, David Broughton AU - Cooper, W A AD - Dorn Veterans Administration Medical Center, Columbia, SC 29201. PY - 1991 SP - 156 EP - 163 VL - 2 IS - 3 SN - 1050-0545, 1050-0545 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85148440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Effect+of+reference+microphone+location+and+loudspeaker+azimuth+on+probe+tube+microphone+measurements.&rft.au=Ickes%2C+M+A%3BHawkins%2C+David+Broughton%3BCooper%2C+W+A&rft.aulast=Ickes&rft.aufirst=M&rft.date=1991-07-01&rft.volume=2&rft.issue=3&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Anxiolytic activity of steroid anesthetic alphaxalone. AN - 80683109; 1677035 AB - The synthetic steroid anesthetic alphaxalone (3 alpha-hydroxy-5 alpha-pregnane-11,20-dione) was studied in two behavioral paradigms known to be sensitive to anxiolytic drugs. In an elevated plus maze, alphaxalone produced an anxiolytic profile, significantly increasing the percentage of entries made into the open arms as well as the percentage of time spent on the open arms. In the conflict test, alphaxalone (6 and 8 mg/kg) produced a significant dose-dependent increase in punished responding and a decrease (8 mg/kg) in unpunished responding. The pattern of responding was similar to that observed with the benzodiazepine agonist chlordiazepoxide (2-8 mg/kg). The increase in punished responding was not altered by the benzodiazepine antagonist Ro 15-1788 and only partially blocked by the picrotoxinin receptor ligand isopropylbicyclophospate (10 and 15 micrograms/kg). The gamma-aminobutyric acid agonists picrotoxin (1 mg/kg) and bicuculline (1 mg/kg) also failed to suppress the rate-increasing effects of alphaxalone in the conflict test. Chronic administration of alphaxalone for 1 week produced no tolerance to the anxiolytic behavioral effects. In addition, no changes in pain threshold were noted with alphaxalone (8 mg/kg) in the tail-flick analgesia test. These results suggest that the pharmacologic substrates for the anxiolytic actions of alphaxalone may be independent of either the benzodiazepine or picrotoxinin binding sites of the gamma-aminobutyric acid/benzodiazepine receptor complex. JF - The Journal of pharmacology and experimental therapeutics AU - Britton, K T AU - Page, M AU - Baldwin, H AU - Koob, G F AD - Department of Psychiatry, San Diego Veterans' Administration Medical Center, California. Y1 - 1991/07/01/ PY - 1991 DA - 1991 Jul 01 SP - 124 EP - 129 VL - 258 IS - 1 SN - 0022-3565, 0022-3565 KW - Anesthetics KW - 0 KW - Anti-Anxiety Agents KW - Pregnanediones KW - alphaxalone KW - BD07M97B2A KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Injections, Intraperitoneal KW - Bicuculline -- pharmacology KW - Animals KW - Drug Interactions KW - Male KW - Conditioning, Operant -- drug effects KW - Behavior, Animal -- drug effects KW - Anti-Anxiety Agents -- pharmacology KW - Anesthetics -- pharmacology KW - Pregnanediones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80683109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Anxiolytic+activity+of+steroid+anesthetic+alphaxalone.&rft.au=Britton%2C+K+T%3BPage%2C+M%3BBaldwin%2C+H%3BKoob%2C+G+F&rft.aulast=Britton&rft.aufirst=K&rft.date=1991-07-01&rft.volume=258&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-20 N1 - Date created - 1991-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cerebellar GABAB receptors modulate function of GABAA receptors. AN - 80666207; 1648524 AB - Interactions between GABAA and GABAB receptors were studied using muscimol-stimulated uptake of 36Cl- by membrane vesicles from mouse cerebellum. Baclofen inhibited muscimol-stimulated 36Cl- uptake and this action was more pronounced with longer flux times (30 vs. 3 s) and after predesensitization of GABAA receptors. Baclofen also inhibited 36Cl- flux by cortical membranes but was more effective with cerebellar preparations. The action of baclofen was stereoselective, calcium-dependent, and blocked by the GABAB receptor antagonist 2-OH-saclofen. It was mimicked by GTP-gamma-S but not by GDP-beta-S, which suggests that baclofen may be acting via a G protein. The action of baclofen was inhibited by U73122, an inhibitor of phospholipase C. However, the potassium channel blockers tetraethylammonium or Ba2+ did not affect the action of baclofen. The results show that activation of GABAB receptors can inhibit the function of GABAA receptors and suggest that this action involves either a nondesensitizing subtype of GABAA receptor or the rate or recycling of desensitized to nondesensitized receptors. We speculate that this action of baclofen results from activation of phospholipase C and phosphorylation of a subtype of GABAA receptor by protein kinase C. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Hahner, L AU - McQuilkin, S AU - Harris, R A AD - Veterans Administration Medical Center, Denver, Colorado. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 2466 EP - 2472 VL - 5 IS - 10 SN - 0892-6638, 0892-6638 KW - Estrenes KW - 0 KW - Pyrrolidinones KW - Receptors, GABA-A KW - Tetraethylammonium Compounds KW - guanosine 5'-O-(1-thiotriphosphate) KW - 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione KW - 112648-68-7 KW - 2-hydroxysaclofen KW - 117354-64-0 KW - Barium KW - 24GP945V5T KW - Muscimol KW - 2763-96-4 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Chlorine KW - 4R7X1O2820 KW - Tetraethylammonium KW - 66-40-0 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Baclofen KW - H789N3FKE8 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Type C Phospholipases -- antagonists & inhibitors KW - Cerebral Cortex -- metabolism KW - Dose-Response Relationship, Drug KW - Tetraethylammonium Compounds -- pharmacology KW - Baclofen -- analogs & derivatives KW - Mice KW - Guanosine 5'-O-(3-Thiotriphosphate) -- analogs & derivatives KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Calcium -- metabolism KW - Cells, Cultured KW - In Vitro Techniques KW - Estrenes -- pharmacology KW - Time Factors KW - Pyrrolidinones -- pharmacology KW - Muscimol -- pharmacology KW - Chlorine -- pharmacokinetics KW - Baclofen -- pharmacology KW - Barium -- pharmacology KW - Receptors, GABA-A -- physiology KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80666207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Cerebellar+GABAB+receptors+modulate+function+of+GABAA+receptors.&rft.au=Hahner%2C+L%3BMcQuilkin%2C+S%3BHarris%2C+R+A&rft.aulast=Hahner&rft.aufirst=L&rft.date=1991-07-01&rft.volume=5&rft.issue=10&rft.spage=2466&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ammonia-induced astrocyte swelling in primary culture. AN - 72463749; 1944774 AB - The effect of ammonia on water space of astrocytes in culture was determined as a means of studying the neurotoxicity of ammonia in fulminant hepatic failure (FHF). Treatment of primary astrocyte cultures obtained from neonatal rat cortices with 10 mM NH4Cl for 4 days resulted in a 29% increase in astrocytic water space, as measured by an isotopic method utilizing 3-O-methyl-[3H]-glucose. This effect was time- and dose-dependent. The ammonia-induced swelling was reversible as the water space in cultures treated with 10 mH NH4Cl for 3 days, and then returned to normal culture media for 1 day, was similar to control cultures. These findings suggest that elevated levels of ammonia lead to astrocyte swelling and may contribute to the brain edema in FHF. JF - Neurochemical research AU - Norenberg, M D AU - Baker, L AU - Norenberg, L O AU - Blicharska, J AU - Bruce-Gregorios, J H AU - Neary, J T AD - Laboratory of Neuropathology, Veterans Administration Medical center, Miami, FL. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 833 EP - 836 VL - 16 IS - 7 SN - 0364-3190, 0364-3190 KW - Methylglucosides KW - 0 KW - Ammonium Chloride KW - 01Q9PC255D KW - Tritium KW - 10028-17-8 KW - 3-O-Methylglucose KW - 146-72-5 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Inbred F344 KW - Methylglucosides -- metabolism KW - Cells, Cultured KW - Kinetics KW - Intracellular Fluid -- physiology KW - Intracellular Fluid -- drug effects KW - Cerebral Cortex -- physiology KW - Astrocytes -- cytology KW - Astrocytes -- drug effects KW - Astrocytes -- physiology KW - Ammonium Chloride -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72463749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Ammonia-induced+astrocyte+swelling+in+primary+culture.&rft.au=Norenberg%2C+M+D%3BBaker%2C+L%3BNorenberg%2C+L+O%3BBlicharska%2C+J%3BBruce-Gregorios%2C+J+H%3BNeary%2C+J+T&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1991-07-01&rft.volume=16&rft.issue=7&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - When they drink too much. Nursing interventions for patients with disordered water balance. AN - 72049241; 1875307 AB - Disordered water balance affects as many as 60% of severely psychiatrically disabled persons. Most patients do not progress to the point of a medical emergency, but are in a state of mild chronic intoxication, making them unavailable for treatment and requiring nursing care to treat the effects of the chronic intoxicated state. Interventions depend on the severity of the disordered water balance and vary from teaching fluid intake control to controlling all patient access to fluids. Nursing management of water intoxication is a trial and error approach. Through a thorough assessment and close observation of the patient, the nurse can determine which interventions would be most appropriate for the patient. JF - Journal of psychosocial nursing and mental health services AU - Snider, K AU - Boyd, M A AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 10 EP - 16 VL - 29 IS - 7 SN - 0279-3695, 0279-3695 KW - Index Medicus KW - Nursing KW - Nursing Diagnosis KW - Nursing Assessment KW - Humans KW - Water Intoxication -- nursing KW - Psychiatric Nursing -- methods KW - Patient Care Planning KW - Water Intoxication -- physiopathology KW - Water Intoxication -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72049241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=When+they+drink+too+much.+Nursing+interventions+for+patients+with+disordered+water+balance.&rft.au=Snider%2C+K%3BBoyd%2C+M+A&rft.aulast=Snider&rft.aufirst=K&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-24 N1 - Date created - 1991-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months. AN - 72047486; 1908248 AB - Studies on fatty acid oxidation were made in rats fed for 6 months on a liquid diet containing 15% total calories as ethanol. After 6 months, a marked diminution was observed in the in vivo production of 14CO2 from labeled palmitate and octanoate in the ethanol-fed animals compared to their pair-fed isocaloric controls not receiving alcohol. Similar results were obtained in 14CO2 formation from 14C-fatty acids using liver mitochondria from these ethanol-fed rats after 6 months. The effect on octanoate beta-oxidation was larger than that for palmitate. Addition of purified acyl CoA dehydrogenase complexes and additional electron transfer flavoprotein complex to the mitochondria suggested that the ethanol-fed animals could have been deficient in the medium-chain acyl CoA-dehydrogenase complex. JF - Alcohol (Fayetteville, N.Y.) AU - Rabinowitz, J L AU - Staeffen, J AU - Hall, C L AU - Brand, J G AD - Veterans Administration Medical Center, Philadelphia, PA 19104. PY - 1991 SP - 241 EP - 246 VL - 8 IS - 4 SN - 0741-8329, 0741-8329 KW - Carbon Dioxide KW - 142M471B3J KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Mitochondria, Liver -- metabolism KW - Mitochondria, Liver -- drug effects KW - Carbon Dioxide -- metabolism KW - Male KW - Alcoholism -- metabolism KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72047486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=A+probable+defect+in+the+beta-oxidation+of+lipids+in+rats+fed+alcohol+for+6+months.&rft.au=Rabinowitz%2C+J+L%3BStaeffen%2C+J%3BHall%2C+C+L%3BBrand%2C+J+G&rft.aulast=Rabinowitz&rft.aufirst=J&rft.date=1991-07-01&rft.volume=8&rft.issue=4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The antisocial personality disorder diagnosis in substance abusers: problems and issues. AN - 72033017; 1869868 AB - This paper examines the question of whether antisocial personality disorder (APD) can be considered a viable substance abuse typology. The data for APD substance abusers are first reviewed with respect to six properties that apply to establishing the validity of a clinical typology. This is followed by a brief description of the historical context and development of current conceptualizations of antisocial personality. Some possible sources of diagnostic unreliability and instability that could serve to limit the validity of the APD diagnosis are then discussed. Finally, evidence indicating considerable psychiatric heterogeneity within APD substance abusers is described. The findings indicate that although APD substance abusers satisfy many of the criteria for a clinical subtype, the fit is sufficiently imprecise to suggest the need for further refinement. We attempt to point out some of the critical questions, issues, and lines of research that could help to guide future efforts to clarify, refine, and revise the APD formulation, particularly as it applies to substance abusers. JF - The Journal of nervous and mental disease AU - Alterman, A I AU - Cacciola, J S AD - Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 401 EP - 409 VL - 179 IS - 7 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Reproducibility of Results KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- classification KW - Prognosis KW - Terminology as Topic KW - Personality Assessment KW - Alcoholism -- psychology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- classification KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- classification KW - Antisocial Personality Disorder -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72033017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=The+antisocial+personality+disorder+diagnosis+in+substance+abusers%3A+problems+and+issues.&rft.au=Alterman%2C+A+I%3BCacciola%2C+J+S&rft.aulast=Alterman&rft.aufirst=A&rft.date=1991-07-01&rft.volume=179&rft.issue=7&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-18 N1 - Date created - 1991-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of a maxillary speech-aid prosthesis for the combined tongue and mandibular resection patient. AN - 85263347; pmid-2072328 AB - The purpose of this investigation was to develop a protocol for the fabrication of a prosthesis that would improve speech in individuals who have undergone complete removal of the tongue and mandible. A 60-year-old man was suffering from severe xerostomia and was unable to produce intelligible speech. Speech analysis without the prosthesis revealed a profound articulatory disorder. With the prosthesis, xerostomia was eliminated and the subject had fewer articulatory errors of severity. Improvement in speech intelligibility was significant at p less than 0.001. JF - The Journal of Prosthetic Dentistry AU - Arcuri, M R AU - Perlman, A L AU - Philippbar, S A AU - Barkmeier, J M AD - Veterans Administration Medical Center, Iowa City, Iowa. PY - 1991 SP - 816 EP - 822 VL - 65 IS - 6 SN - 0022-3913, 0022-3913 KW - Tongue Neoplasms KW - Human KW - Phonetics KW - Speech Intelligibility KW - Speech Therapy KW - Sound Spectrography KW - Surgical Flaps KW - Xerostomia KW - Mandible KW - Articulation Disorders KW - Middle Age KW - Prosthesis Design KW - Case Report KW - Tongue KW - Carcinoma, Squamous Cell KW - Male KW - Maxillofacial Prosthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85263347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Prosthetic+Dentistry&rft.atitle=The+effects+of+a+maxillary+speech-aid+prosthesis+for+the+combined+tongue+and+mandibular+resection+patient.&rft.au=Arcuri%2C+M+R%3BPerlman%2C+A+L%3BPhilippbar%2C+S+A%3BBarkmeier%2C+J+M&rft.aulast=Arcuri&rft.aufirst=M&rft.date=1991-06-01&rft.volume=65&rft.issue=6&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Prosthetic+Dentistry&rft.issn=00223913&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Interleukin-2, cisplatin, and 5-fluorouracil for patients with non-small cell lung and head/neck carcinomas. AN - 80730465; 1651106 AB - The feasibility and efficacy of treating patients with locally recurrent or metastatic non-small cell lung cancer (NSCLC) or head/neck cancer with interleukin-2 (IL-2), cisplatin, and 5-fluorouracil (5-FU) was tested. Treatment was given every 28 days and consisted of cisplatin, 100 mg/m2 on days 1 and 8; 5-FU, 1,000 mg/m2 by continuous infusion on days 1-3; and IL-2, 12 million units/m2 by i.v. bolus on days 15-19. Thirty-four patients (22 NSCLC, 12 head/neck cancer) were registered in the study. The median age was 58 years; 59% had Karnofsky performance status of 70-80% and over one-half received prior therapy. All patients were evaluable for toxicity and 29 (18 NSCLC, 11 head/neck cancer) were evaluable for response. Twenty-five patients experienced at least one grade 3 or 4 toxicity, but these toxicities were transient and, in general, well tolerated. The response rate was 37% for NSCLC (0 complete response, 7 partial response) and 55% for head/neck cancer (2 complete response, 4 partial response). Two patients with head/neck cancer responded to treatment after failing prior therapy with cisplatin/5-FU alone. The combination of IL-2, cisplatin, and 5-FU is tolerable and active for treatment of NSCLC and head/neck carcinoma; the combination may not be cross-resistant with other chemotherapy combinations. Further studies of IL-2 combined with cisplatin/5-FU are warranted to determine the most effective dose and schedule. JF - Journal of immunotherapy : official journal of the Society for Biological Therapy AU - Valone, F H AU - Gandara, D R AU - Deisseroth, A B AU - Perez, E A AU - Rayner, A AU - Aronson, F R AU - Luce, J AU - Paradise, C AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94941. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 207 EP - 213 VL - 10 IS - 3 SN - 1053-8550, 1053-8550 KW - Interleukin-2 KW - 0 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Drug Evaluation KW - Interleukin-2 -- administration & dosage KW - Drug Administration Schedule KW - Survival Rate KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Cisplatin -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- drug therapy KW - Head and Neck Neoplasms -- mortality KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80730465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.atitle=Interleukin-2%2C+cisplatin%2C+and+5-fluorouracil+for+patients+with+non-small+cell+lung+and+head%2Fneck+carcinomas.&rft.au=Valone%2C+F+H%3BGandara%2C+D+R%3BDeisseroth%2C+A+B%3BPerez%2C+E+A%3BRayner%2C+A%3BAronson%2C+F+R%3BLuce%2C+J%3BParadise%2C+C&rft.aulast=Valone&rft.aufirst=F&rft.date=1991-06-01&rft.volume=10&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.issn=10538550&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-17 N1 - Date created - 1991-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validity of the MCMI Drug Abuse Scale varies as a function of drug choice, race, and axis II subtypes. AN - 80716644; 1862789 AB - The validity of the Drug Abuse Scale (T) from the Million Clinical Multiaxial Inventory (MCMI) was studied by administering the MCMI to 110 male veterans seeking treatment for opioid or cocaine dependence. Only 26 and 23% of the sample obtained base rate (BR) scores above the clinical relevant cutoffs of 84 and 74, respectively. Covariables associated with elevated scores on the T Scale were Black race, presence of narcissistic/antisocial personality features, and more severe psychopathology in general. The authors urge caution in using the Drug Abuse Scale for the purpose of identifying drug abusers. JF - The American journal of drug and alcohol abuse AU - Calsyn, D A AU - Saxon, A J AU - Daisy, F AD - Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 153 EP - 159 VL - 17 IS - 2 SN - 0095-2990, 0095-2990 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Prognosis KW - Psychometrics KW - Male KW - Opioid-Related Disorders -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Personality Disorders -- diagnosis KW - Opioid-Related Disorders -- psychology KW - Personality Inventory -- statistics & numerical data KW - African Americans -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Personality Disorders -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Personality Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80716644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Validity+of+the+MCMI+Drug+Abuse+Scale+varies+as+a+function+of+drug+choice%2C+race%2C+and+axis+II+subtypes.&rft.au=Calsyn%2C+D+A%3BSaxon%2C+A+J%3BDaisy%2C+F&rft.aulast=Calsyn&rft.aufirst=D&rft.date=1991-06-01&rft.volume=17&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isobolographic analysis of analgesic interactions between intrathecally and intracerebroventricularly administered fentanyl, morphine and D-Ala2-D-Leu5-enkephalin in morphine-tolerant and nontolerant mice. AN - 80603181; 1646321 AB - Concurrent administration of morphine sulfate i.c.v. and i.t. produces a multiplicative interaction for analgesia in the tail flick response in mice. This interaction decreases to an additive interaction in mice which are tolerant to s.c. morphine. To test the responses of opioids selective for mu or delta receptors, the present study examined the interactions between fentanyl citrate (mu agonist) and D-Ala2-D-Leu5 enkephalin (DADLE, a relatively selective delta agonist) administered i.c.v. and i.t. using the tail flick test in control and morphine pellet-implanted mice. A method was developed for assigning statistical significance to the resulting ED50 values when analyzed isobolographically. When fentanyl or DADLE was administered i.c.v. plus i.t., an additive interaction between sites occurred in control animals, which changed to an antagonistic interaction for fentanyl and a multiplicative interaction for DADLE after morphine pellet treatment. When morphine was given i.c.v. along with i.t. fentanyl or DADLE in control animals, multiplicative interactions occurred when equipotent doses were given. Thus, opioids which were more receptor-selective than morphine did not produce multiplicative interactions, but were multiplicative when given with morphine. These results suggest that activation of combinations of receptors (by morphine) was required for the multiplicative interaction. The supraspinal site involved mu receptors (which are not self-sufficient and require an additional component) and the spinal site involved mu or delta receptors. The use of isobolographic analysis required that the drugs, when administered concurrently at two sites, be given in a constant dose ratio. JF - The Journal of pharmacology and experimental therapeutics AU - Roerig, S C AU - Hoffman, R G AU - Takemori, A E AU - Wilcox, G L AU - Fujimoto, J M AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 1091 EP - 1099 VL - 257 IS - 3 SN - 0022-3565, 0022-3565 KW - Receptors, Opioid KW - 0 KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - Enkephalin, Leucine-2-Alanine KW - 63631-40-3 KW - Morphine KW - 76I7G6D29C KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Drug Tolerance KW - Animals KW - Drug Interactions KW - Injections, Spinal KW - Mice KW - Male KW - Receptors, Opioid -- physiology KW - Mathematics KW - Injections, Intraventricular KW - Fentanyl -- pharmacology KW - Enkephalin, Leucine-2-Alanine -- pharmacology KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80603181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Isobolographic+analysis+of+analgesic+interactions+between+intrathecally+and+intracerebroventricularly+administered+fentanyl%2C+morphine+and+D-Ala2-D-Leu5-enkephalin+in+morphine-tolerant+and+nontolerant+mice.&rft.au=Roerig%2C+S+C%3BHoffman%2C+R+G%3BTakemori%2C+A+E%3BWilcox%2C+G+L%3BFujimoto%2C+J+M&rft.aulast=Roerig&rft.aufirst=S&rft.date=1991-06-01&rft.volume=257&rft.issue=3&rft.spage=1091&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-12 N1 - Date created - 1991-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium citrate markedly enhances aluminum absorption from aluminum hydroxide. AN - 80596840; 2042654 AB - The effect of calcium citrate on intestinal aluminum absorption, assessed by the increment in urinary aluminum excretion, was evaluated in eight normal men. Baseline urinary aluminum excretion was determined for 2 days; thereafter, subjects ingested aluminum hydroxide for 3 days. In a cross-over study, subjects were given either calcium citrate, 950 mg four times a day, or placebo during the 3 days of aluminum hydroxide ingestion (2.4 g/d). Plasma aluminum levels were measured on the second control day and the third day of aluminum hydroxide ingestion. Baseline urinary aluminum excretion was 0.02 +/- 0.004 (6.5 +/- 1.1 micrograms/g creatinine) and 0.03 +/- 0.005 mumol/mmol creatinine (7.4 +/- 1.3 micrograms/g creatinine). These values increased during aluminum hydroxide therapy, but values were much greater when calcium citrate was ingested with aluminum hydroxide. On 3 consecutive days, urinary aluminum excretion levels were 11.1 +/- 3.23, 8.8 +/- 2.9, and 5.3 +/- 0.7 times greater during the administration of calcium citrate with aluminum hydroxide than with aluminum hydroxide alone. Plasma aluminum levels did not differ in the two treatment groups. Thus, calcium citrate markedly enhances the absorption of aluminum from aluminum hydroxide and the two must not be prescribed together in patients with renal failure. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Coburn, J W AU - Mischel, M G AU - Goodman, W G AU - Salusky, I B AD - Medical Service, West Los Angeles Veterans Administration Center (Wadsworth Division), CA 90073. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 708 EP - 711 VL - 17 IS - 6 SN - 0272-6386, 0272-6386 KW - Antacids KW - 0 KW - Citrates KW - Citric Acid KW - 2968PHW8QP KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Reference Values KW - Humans KW - Adult KW - Middle Aged KW - Intestinal Absorption -- drug effects KW - Drug Synergism KW - Time Factors KW - Male KW - Aluminum -- urine KW - Antacids -- contraindications KW - Aluminum -- blood KW - Citrates -- contraindications KW - Antacids -- pharmacokinetics KW - Aluminum Hydroxide -- contraindications KW - Aluminum -- pharmacokinetics KW - Citrates -- pharmacokinetics KW - Aluminum Hydroxide -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80596840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Calcium+citrate+markedly+enhances+aluminum+absorption+from+aluminum+hydroxide.&rft.au=Coburn%2C+J+W%3BMischel%2C+M+G%3BGoodman%2C+W+G%3BSalusky%2C+I+B&rft.aulast=Coburn&rft.aufirst=J&rft.date=1991-06-01&rft.volume=17&rft.issue=6&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-10 N1 - Date created - 1991-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mucosal vascular stasis precedes loss of viability of endothelial cells in rat acetic acid colitis. AN - 80563138; 2032512 AB - The hypothesis that a significant reduction in colonic mucosal perfusion, and hence ischemic injury, precedes the development of mucosal ulceration and inflammation is tested in this report. The microcirculatory changes in the rat colonic mucosa within 1 hr of topical exposure to 10% acetic acid were assessed. Colonic mucosal blood flow signals measured by laser Doppler flowmetry were significantly reduced to 61 +/- 8, 52 +/- 10, and 37 +/- 13% (mean +/- SEM) of baseline values at 1 min, 4 min, and 10 min after the colonic mucosa was exposed to 10% acetic acid, respectively, but not in controls exposed to saline. After the start of application of 10% acetic acid (for 4 min), in vivo microscopy studies demonstrated that colonic mucosal ischemia (stasis of the red blood cells in the mucosal capillaries) occurred at 9 +/- 5 min (mean +/- SEM). Evidence of endothelial cell death (failure to exclude a fluorescent dye, propidium iodide, by endothelial cells) developed at 25 +/- 10 min (mean +/- SEM). These findings indicate that within minutes after contact of the colonic mucosa with 10% acetic acid, colonic mucosal ischemia develops, followed shortly by death of endothelial cells. The data do not establish a cause-and-effect relationship between the reductions in mucosal blood flow and loss of endothelial cell viability in response to acetic acid. Nevertheless, because these events occur at such an early time point, they may play a pathogenetic role in the development of the subsequent inflammatory and ulcerative changes in this animal model of colitis. Further studies to define the potential causal relationships between these parameters are warranted. JF - Digestive diseases and sciences AU - Leung, F W AU - Koo, A AD - Research Service, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 727 EP - 732 VL - 36 IS - 6 SN - 0163-2116, 0163-2116 KW - Acetates KW - 0 KW - Acetic Acid KW - Q40Q9N063P KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Microcirculation -- drug effects KW - Regional Blood Flow -- drug effects KW - Time Factors KW - Endothelium, Vascular -- pathology KW - Colitis -- pathology KW - Colitis -- chemically induced KW - Ischemia -- chemically induced KW - Intestinal Mucosa -- blood supply KW - Colon -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80563138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Mucosal+vascular+stasis+precedes+loss+of+viability+of+endothelial+cells+in+rat+acetic+acid+colitis.&rft.au=Leung%2C+F+W%3BKoo%2C+A&rft.aulast=Leung&rft.aufirst=F&rft.date=1991-06-01&rft.volume=36&rft.issue=6&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. AN - 80562415; 2033247 AB - Ligand-induced activation of T cells results in stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC). A structurally diverse family of PI-PLC isoforms has recently been defined, and more than one isoform is frequently coexpressed in a single cell or tissue, suggesting that different forms may play distinct roles in cellular activation, proliferation, or differentiation. We show here that both PLC-alpha and PLC-gamma are expressed in rat splenic T cells and in Jurkat cells (a human T cell line). Activation of Jurkat cells with the combination of PMA and PHA leads to increased expression of PLC-alpha message and decreased expression of PLC-gamma message after 4 h of stimulation. The increase in PLC-alpha transcripts was detectable at 4 h, maximal at 6 h, and remained elevated for at least 24 h. The decrease in PLC-gamma message was transient, with a maximal effect at 4 h, and a return to basal levels by 6 h. Changes in PI-PLC transcripts were also induced by the combination of PMA and the calcium ionophore, ionomycin. These data demonstrate that the expression of transcripts for PLC-alpha and PLC-gamma can be differentially regulated during a cellular response, and raise the possibility that these two isoforms of PI-PLC subserve distinct functions in T cell activation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Goldfien, R D AU - Seaman, W E AU - Hempel, W M AU - Imboden, J B AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/06/01/ PY - 1991 DA - 1991 Jun 01 SP - 3703 EP - 3708 VL - 146 IS - 11 SN - 0022-1767, 0022-1767 KW - Isoenzymes KW - 0 KW - Phytohemagglutinins KW - Type C Phospholipases KW - EC 3.1.4.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Phytohemagglutinins -- pharmacology KW - Cell Line KW - Lymphocyte Activation KW - Isoenzymes -- biosynthesis KW - Type C Phospholipases -- biosynthesis KW - Transcription, Genetic KW - Type C Phospholipases -- genetics KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80562415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Divergent+regulation+of+phospholipase+C-alpha+and+phospholipase+C-gamma+transcripts+during+activation+of+a+human+T+cell+line.&rft.au=Goldfien%2C+R+D%3BSeaman%2C+W+E%3BHempel%2C+W+M%3BImboden%2C+J+B&rft.aulast=Goldfien&rft.aufirst=R&rft.date=1991-06-01&rft.volume=146&rft.issue=11&rft.spage=3703&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-25 N1 - Date created - 1991-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Squamous cell carcinoma of the scrotum. AN - 72060144; 1879176 AB - A patient with psoriasis was found to have a large mass on his scrotum. He was at increased risk for the occurrence of skin cancer, both from the treatments he received for control of his psoriasis and from previous occupational exposure. We present his case and review the risk factors involved. JF - Cutis AU - Gross, D J AU - Schosser, R H AD - Department of Dermatology, John L. McClellan Veterans Administration Hospital, Little Rock, Arkansas. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 402 EP - 404 VL - 47 IS - 6 SN - 0011-4162, 0011-4162 KW - Polycyclic Compounds KW - 0 KW - Index Medicus KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- pathology KW - Risk Factors KW - Humans KW - Psoriasis -- drug therapy KW - Occupational Exposure -- adverse effects KW - Aged KW - Polycyclic Compounds -- adverse effects KW - Male KW - Genital Neoplasms, Male -- pathology KW - Scrotum -- pathology KW - Genital Neoplasms, Male -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72060144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Squamous+cell+carcinoma+of+the+scrotum.&rft.au=Gross%2C+D+J%3BSchosser%2C+R+H&rft.aulast=Gross&rft.aufirst=D&rft.date=1991-06-01&rft.volume=47&rft.issue=6&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-02 N1 - Date created - 1991-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes with age in the proliferative response of splenic T cells from rats exposed to ethanol in utero. AN - 72053114; 1877729 AB - The fetal alcohol syndrome is associated with altered immunity. Several laboratories have confirmed that rodents exposed to ethanol in utero demonstrate both diminished proliferative responses of T cells to mitogens and diminished proliferative responses of T-blast cells to human recombinant interleukin 2 (rIL2). We examined the developmental time course of these altered immune responses by testing the immune function of in utero ethanol-exposed rats at various ages. We found that while diminished splenic T cell proliferative responses could not be detected at 2 weeks, they were present at 6 weeks after birth and suppression was maximal at 6 weeks and 3 months. Thereafter, at 5 and 7 months, the altered immune responses gradually declined and normalized at 8 months of age. Thus, both altered T cell mitogenesis and the blunted IL2-induced proliferative response of T-blast cells could serve as biomarkers of fetal exposure to ethanol. JF - Alcoholism, clinical and experimental research AU - Norman, D C AU - Chang, M P AU - Wong, C M AU - Branch, B J AU - Castle, S AU - Taylor, A N AD - GRECC, Veterans Administration Medical Center West Lost Angeles, CA 90073. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 428 EP - 432 VL - 15 IS - 3 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Immune Tolerance -- drug effects KW - Animals KW - Age Factors KW - Spleen -- immunology KW - Immune Tolerance -- immunology KW - Spleen -- drug effects KW - Male KW - Female KW - Pregnancy KW - Lymphocyte Activation -- drug effects KW - Lymphocyte Activation -- immunology KW - Ethanol -- toxicity KW - T-Lymphocytes -- drug effects KW - Fetal Alcohol Spectrum Disorders -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72053114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Changes+with+age+in+the+proliferative+response+of+splenic+T+cells+from+rats+exposed+to+ethanol+in+utero.&rft.au=Norman%2C+D+C%3BChang%2C+M+P%3BWong%2C+C+M%3BBranch%2C+B+J%3BCastle%2C+S%3BTaylor%2C+A+N&rft.aulast=Norman&rft.aufirst=D&rft.date=1991-06-01&rft.volume=15&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin B12 and folate status in rats after chronic administration of ethanol and acute exposure to nitrous oxide. AN - 72050457; 1877742 AB - The chronic administration of ethanol or brief exposure to nitrous oxide (N2O) decreases the activity of hepatic methionine synthase and disrupts normal metabolic processes that require folate and vitamin B12. This combination of drugs has clinical relevance since alcoholic patients often require surgery and receive N2O as a component of their anesthetic. To assess this clinical problem using a rodent model, rats were given a liquid ethanol diet (35% of calories as ethanol) and control rats were pair-fed a liquid diet with carbohydrate substituting for the caloric content of ethanol. After receiving liquid diets for 6 weeks, rats were exposed to 60% N2O/40% O2 for 6 hr. Urinary excretions of formic acid and formiminoglutamic acid (FIGLU) were used as indirect markers of folate status. In both the ethanol-fed and control groups, excretion of formic acid and FIGLU markedly increased the first day after N2O and returned towards background values by the second day after N2O exposure. Ethanol treatment alone decreased methionine synthase activities in liver, but not kidney or brain. Exposure to N2O further decreased methionine synthase activities, and recovery of methionine synthase activity after N2O occurred over a period of 4 days at the same rate in both the ethanol-fed and control groups. Ethanol treatment for 6 weeks combined with acute exposure to N2O did not deplete the rats of vitamin B12 in blood, liver, kidney, or brain. We conclude that in this animal model, chronic treatment with ethanol does not markedly exacerbate the disturbances in folate/vitamin B12 metabolism caused by brief exposure to N2O. JF - Alcoholism, clinical and experimental research AU - Koblin, D D AU - Everman, B W AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 543 EP - 548 VL - 15 IS - 3 SN - 0145-6008, 0145-6008 KW - Formates KW - 0 KW - formic acid KW - 0YIW783RG1 KW - Formiminoglutamic Acid KW - 816-90-0 KW - Folic Acid KW - 935E97BOY8 KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase KW - EC 2.1.1.13 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Liver -- enzymology KW - Liver -- drug effects KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- blood KW - Formiminoglutamic Acid -- urine KW - Formates -- urine KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- antagonists & inhibitors KW - Male KW - Alcoholism -- enzymology KW - Nitrous Oxide -- toxicity KW - Folic Acid -- blood KW - Vitamin B 12 -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72050457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Vitamin+B12+and+folate+status+in+rats+after+chronic+administration+of+ethanol+and+acute+exposure+to+nitrous+oxide.&rft.au=Koblin%2C+D+D%3BEverman%2C+B+W&rft.aulast=Koblin&rft.aufirst=D&rft.date=1991-06-01&rft.volume=15&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beneficial effects of nicotine. AN - 80711114; 1859921 AB - Nicotine in tobacco brings illness and death to millions of people. Yet nicotine in its pure form has the potential to be a valuable pharmaceutical agent. Nicotine fairly specifically binds to the cholinergic nicotinic gating site on cationic ion channels in receptors throughout the body. This action stimulates the release of a variety of neurotransmitters including especially catecholamines and serotonin. When chronically taken, nicotine may result in: (1) positive reinforcement, (2) negative reinforcement, (3) reduction of body weight, (4) enhancement of performance, and protection against; (5) Parkinson's disease (6) Tourette's disease (7) Alzheimers disease, (8) ulcerative colitis and (9) sleep apnea. The reliability of these effects varies greatly but justifies the search for more therapeutic applications for this interesting compound. JF - British journal of addiction AU - Jarvik, M E AD - Veterans Administration Medical Center, Brentwood Division, Los Angeles. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 571 EP - 575 VL - 86 IS - 5 SN - 0952-0481, 0952-0481 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Animals KW - Affect -- drug effects KW - Arousal -- drug effects KW - Neurocognitive Disorders -- psychology KW - Humans KW - Substance Withdrawal Syndrome -- psychology KW - Smoking -- psychology KW - Attention -- drug effects KW - Mental Recall -- drug effects KW - Nicotine -- therapeutic use KW - Nicotine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80711114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+addiction&rft.atitle=Beneficial+effects+of+nicotine.&rft.au=Jarvik%2C+M+E&rft.aulast=Jarvik&rft.aufirst=M&rft.date=1991-05-01&rft.volume=86&rft.issue=5&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=British+journal+of+addiction&rft.issn=09520481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The measurement of denial and rationalization in male alcoholics. AN - 80663940; 2066419 AB - Two hundred male alcoholics were given 94 true-false items constructed to characterize alcoholic defensiveness, and a factor analysis revealed two strong factors. The first factor (Denial) was correlated with items that asserted an ability to control one's drinking, denied being an alcoholic or needing treatment, or minimized the consequences of alcohol abuse. Items that loaded the other factor (Rationalization) gave reasons, justifications, and excuses for drinking. Two derived scales were examined in a replication sample of 66 male alcoholics, and alpha coefficients (.84 and .85) from the first sample did not show undue shrinkage in the second (.86 and .77). JF - Journal of clinical psychology AU - Ward, L C AU - Rothaus, P AD - Veterans Administration Medical Center Tuscaloosa, Alabama. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 465 EP - 468 VL - 47 IS - 3 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Verbal Behavior KW - Humans KW - Adult KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Defense Mechanisms KW - Alcoholism -- rehabilitation KW - Denial (Psychology) KW - Rationalization KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80663940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=The+measurement+of+denial+and+rationalization+in+male+alcoholics.&rft.au=Ward%2C+L+C%3BRothaus%2C+P&rft.aulast=Ward&rft.aufirst=L&rft.date=1991-05-01&rft.volume=47&rft.issue=3&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-14 N1 - Date created - 1991-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. AN - 80555130; 2029994 AB - To assess the effectiveness of propranolol in the prevention of initial variceal hemorrhage, a double-blind, randomized trial was carried out in three centers. Patients with cirrhosis (78% alcoholic), hepatic venous pressure gradients greater than 12 mm Hg and endoscopically proven esophageal varices were randomly assigned to propranolol (51 patients) or placebo (51 patients). Of the 102 patients, 58% were Child's class A, 34% were Child's class B and 8% were Child's class C. Daily dosage was determined by the administration of progressively increasing doses of propranolol with the hepatic vein catheter in place to achieve a 25% decrease in hepatic venous pressure gradient, a decrease in hepatic venous pressure gradient to less than 12 mm Hg or a decrease in resting heart rate to less than 55 beats/min. During a mean follow-up period of 16.3 mo, 11 patients in the placebo group (22%) bled from esophageal varices compared with 2 in the propranolol group (4%) during a mean period of 17.1 mo (p less than 0.01). Three additional patients (6%) in the placebo group bled from portal hypertensive gastropathy compared with none in the propranolol group. Propranolol appeared effective in preventing bleeding from large varices. Eleven deaths (22%) occurred in the placebo group compared with eight deaths (16%) in the propranolol group (NS). The mean dose of propranolol was 132 mg/day, and the median dose was 80 mg/day. Using a compliance index (pill count, clinic attendance, alcohol and propranolol levels and alcohol history), 81% of the propranolol patients and 77% of the placebo patients were considered compliant. Complications severe enough to require cessation of therapy occurred in eight patients (16%) in the propranolol group and four in the placebo group (8%) (NS). We conclude that propranolol effectively prevents the first variceal hemorrhage in patients with alcoholic cirrhosis and large esophageal varices but does not improve survival. JF - Hepatology (Baltimore, Md.) AU - Conn, H O AU - Grace, N D AU - Bosch, J AU - Groszmann, R J AU - Rodés, J AU - Wright, S C AU - Matloff, D S AU - Garcia-Tsao, G AU - Fisher, R L AU - Navasa, M AD - Medical Service, West Haven Veterans Administration Medical Center, Yale University School of Medicine, Connecticut 06516. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 902 EP - 912 VL - 13 IS - 5 SN - 0270-9139, 0270-9139 KW - Propranolol KW - 9Y8NXQ24VQ KW - Index Medicus KW - Liver Cirrhosis, Alcoholic -- complications KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Patient Compliance KW - Humans KW - Middle Aged KW - Hypertension, Portal -- complications KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Propranolol -- therapeutic use KW - Gastrointestinal Hemorrhage -- prevention & control KW - Esophageal and Gastric Varices -- complications KW - Propranolol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80555130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Propranolol+in+the+prevention+of+the+first+hemorrhage+from+esophagogastric+varices%3A+A+multicenter%2C+randomized+clinical+trial.+The+Boston-New+Haven-Barcelona+Portal+Hypertension+Study+Group.&rft.au=Conn%2C+H+O%3BGrace%2C+N+D%3BBosch%2C+J%3BGroszmann%2C+R+J%3BRod%C3%A9s%2C+J%3BWright%2C+S+C%3BMatloff%2C+D+S%3BGarcia-Tsao%2C+G%3BFisher%2C+R+L%3BNavasa%2C+M&rft.aulast=Conn&rft.aufirst=H&rft.date=1991-05-01&rft.volume=13&rft.issue=5&rft.spage=902&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-17 N1 - Date created - 1991-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. AN - 80531089; 2021479 AB - Exposure to oxidants permeabilizes cell membranes and liberates unesterified fatty acids (UFA) in a variety of cell types, including endothelial cells. Products of phospholipase activity, particularly UFA and lysophosphatides, possess potent detergent-like properties, and we postulated that oxidant injury might be mediated by the accumulation of these toxic phospholipase products. Several radiolabels were incorporated into defined positions in the phospholipids of cultured, confluent bovine pulmonary endothelial cells (BPAEC). The release of radiolabeled fatty acids and the accumulation of cell-associated phospholipase products were measured and compared to a standard cytotoxicity assay (51Cr release) in response to an oxidant stress, in this case 0.1 to 10 mM hydrogen peroxide (H2O2). H2O2 caused time- and dose-dependent 51Cr release as well as liberation of saturated ([14C]stearic acid) and unsaturated ([3H]arachidonic acid) fatty acids and the accumulation of phospholipase A2 and C products. The ability of BPAEC to incorporate UFA into complex phospholipids was shown to be severely impaired in the presence of H2O2. Further studies showed that H2O2 caused depletion of BPAEC adenosine triphosphate (ATP) content to undetectable levels, and that the depletion of cellular ATP by iodoacetic acid induced substantial release of [3H]arachidonic acid but not [14C]stearic acid from BPAEC. This finding suggests that release of UFA in response to an oxidant stress may be due in part to a defect in ATP-dependent reacylation pathways and need not reflect any increase in phospholipase activities. Also unsaturated fatty acids were found to be toxic to BPAEC upon adding them to supernatants of cultured monolayers. JF - American journal of respiratory cell and molecular biology AU - Duane, P G AU - Rice, K L AU - Charboneau, D E AU - King, M B AU - Gilboe, D P AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 408 EP - 416 VL - 4 IS - 5 SN - 1044-1549, 1044-1549 KW - Arachidonic Acids KW - 0 KW - Chromium Radioisotopes KW - Phospholipids KW - Stearic Acids KW - stearic acid KW - 4ELV7Z65AP KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Phospholipases KW - EC 3.1.- KW - Index Medicus KW - Animals KW - Cattle KW - Arachidonic Acids -- metabolism KW - Lipid Peroxidation KW - Stearic Acids -- metabolism KW - Cell Line KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Pulmonary Artery -- metabolism KW - Phospholipids -- metabolism KW - Phospholipases -- metabolism KW - Hydrogen Peroxide -- pharmacology KW - Adenosine Triphosphate -- metabolism KW - Pulmonary Artery -- enzymology KW - Pulmonary Artery -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80531089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Relationship+of+oxidant-mediated+cytotoxicity+to+phospholipid+metabolism+in+endothelial+cells.&rft.au=Duane%2C+P+G%3BRice%2C+K+L%3BCharboneau%2C+D+E%3BKing%2C+M+B%3BGilboe%2C+D+P%3BNiewoehner%2C+D+E&rft.aulast=Duane&rft.aufirst=P&rft.date=1991-05-01&rft.volume=4&rft.issue=5&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Levels of opioid physical dependence in heroin addicts. AN - 72072081; 1884668 AB - The levels of opioid physical dependence in a group of long-term heroin addicts were ascertained by measuring the severity of the opioid withdrawal syndrome before and after pharmacological challenge with either 0.4 mg naloxone or placebo. Prior to challenge, patients manifested some subjective symptoms but few objective signs of opioid withdrawal. Patients who received placebo (n = 18) showed a significant increase in the mean score on one of three rating scales used to assess opioid withdrawal. Patients who received naloxone (n = 58) showed significant increases in mean scores on all three rating scales, but this was due primarily to increases observed in a minority of patients. Sixty-one percent of patients failed to manifest clinically significant changes in subjective symptoms, and 74% of patients failed to manifest clinically significant changes in objective signs of opioid withdrawal following naloxone administration. The results suggest that a substantial subgroup of heroin addicts are able to use opioids regularly while maintaining relatively low levels of physical dependence. JF - Drug and alcohol dependence AU - Kanof, P D AU - Aronson, M J AU - Ness, R AU - Cochrane, K J AU - Horvath, T B AU - Handelsman, L AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, New York 10468. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 253 EP - 262 VL - 27 IS - 3 SN - 0376-8716, 0376-8716 KW - Naloxone KW - 36B82AMQ7N KW - Heroin KW - 70D95007SX KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Drug Tolerance KW - Methadone -- therapeutic use KW - Humans KW - Adult KW - Neurologic Examination KW - Middle Aged KW - Male KW - Heroin -- adverse effects KW - Substance Withdrawal Syndrome -- rehabilitation KW - Substance Withdrawal Syndrome -- diagnosis KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72072081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Levels+of+opioid+physical+dependence+in+heroin+addicts.&rft.au=Kanof%2C+P+D%3BAronson%2C+M+J%3BNess%2C+R%3BCochrane%2C+K+J%3BHorvath%2C+T+B%3BHandelsman%2C+L&rft.aulast=Kanof&rft.aufirst=P&rft.date=1991-05-01&rft.volume=27&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-07 N1 - Date created - 1991-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence, onset, and risk of psychiatric disorders in men with chronic low back pain: a controlled study. AN - 72053256; 1831555 AB - This study used structured diagnostic interviews and DSM-III criteria to assess lifetime prevalence and pre-morbid risk of psychiatric disorder in a sample of men with long-standing chronic back pain (CLPB) attending a primary care clinic. A control group of age and demographically matched men without history of back pain was also studied. Compared to controls, men with CLBP had significantly higher lifetime rates of major depression (32% vs. 16%), alcohol use disorder (64.9% vs. 38.8%), and a major anxiety disorder (30.9% vs. 14.3%). Almost all CLBP men ever experiencing a mood disorder reported recurrent, not single, episodes. The 6 month point prevalence of major depression, but not other disorders, was also significantly elevated for men with CLBP. In CLBP, the first episode of major depression generally (58.1%) followed pain onset. While the initial major depressive episode usually commenced within the first 2 years of established pain, late onset mood disorder was also common. By comparison in most cases (81%) onset of alcohol use disorders considerably preceded pain. When an age-matching procedure was used to gauge relative vulnerability to psychiatric illness in patients and controls, CLBP patients had significantly higher pre-pain rates of alcohol use disorder but not depression. After age of pain onset, CLBP subjects had over 9 times the risk of developing major depression, but had similar rates of developing alcoholism. We conclude that (1) alcohol use disorders rather than depression may increase risk of developing CLBP, and (2) risk of new onset and recurrent major depression remains high for men throughout their pain career. This suggests that psychological adaptation to long-standing pain may be less successful than previously thought, especially with regard to recurrent mood disorder. JF - Pain AU - Atkinson, J H AU - Slater, M A AU - Patterson, T L AU - Grant, I AU - Garfin, S R AD - Psychiatry Service, San Diego Veterans Administration Medical Center, CA 92161. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 111 EP - 121 VL - 45 IS - 2 SN - 0304-3959, 0304-3959 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Chronic Disease KW - Alcoholism -- physiopathology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Male KW - Prevalence KW - Back Pain -- psychology KW - Back Pain -- epidemiology KW - Back Pain -- physiopathology KW - Mental Disorders -- epidemiology KW - Back Pain -- complications KW - Mental Disorders -- psychology KW - Mental Disorders -- complications KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72053256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Prevalence%2C+onset%2C+and+risk+of+psychiatric+disorders+in+men+with+chronic+low+back+pain%3A+a+controlled+study.&rft.au=Atkinson%2C+J+H%3BSlater%2C+M+A%3BPatterson%2C+T+L%3BGrant%2C+I%3BGarfin%2C+S+R&rft.aulast=Atkinson&rft.aufirst=J&rft.date=1991-05-01&rft.volume=45&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=03043959&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-24 N1 - Date created - 1991-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Do-Not-Resuscitate Orders at a Chronic Care Hospital AN - 1761715243; 199200175 AB - To study the use of do-not-resuscitate (DNR) orders, their frequency, decisionmakers involved, patient characteristics, further medical interventions, & short-term outcomes, medical records of 301 patients admitted 1985/86 to a chronic care hospital in Mass were surveyed. In the first 6 weeks of hospitalization DNR orders were issued for 58 patients, requested by: their families (73%), the patients themselves (18%), & physicians (6%). Patients with DNR orders were more likely to be demented, incontinent, & unable to perform other routine functions; they continued to receive medical interventions, but were considered likely to die. 3 Tables, 20 References. M. Malas JF - Journal of the American Geriatrics Society AU - Berlowitz, Dan R AU - Wilking, Spencer V B AU - Moskowitz, Mark A AD - Medical Service Bedford Veterans Administration Hospital, 200 Springs Rd MA 01730 Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 472 EP - 476 VL - 39 IS - 5 SN - 0002-8614, 0002-8614 KW - do-not-resuscitate orders, decision-making processes, chronic care hospital patients KW - medical records KW - Massachusetts KW - Professional Ethics KW - Terminal Illness KW - Medical Technology KW - Emergencies KW - Nursing Homes KW - Treatment Methods KW - article KW - 7211: health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761715243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Do-Not-Resuscitate+Orders+at+a+Chronic+Care+Hospital&rft.au=Berlowitz%2C+Dan+R%3BWilking%2C+Spencer+V+B%3BMoskowitz%2C+Mark+A&rft.aulast=Berlowitz&rft.aufirst=Dan&rft.date=1991-05-01&rft.volume=39&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical Technology; Terminal Illness; Treatment Methods; Professional Ethics; Emergencies; Nursing Homes; Massachusetts ER - TY - JOUR T1 - Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. AN - 80523531; 1850412 AB - The signals controlling the expression of the receptor protein for 1 alpha,25-dihydroxyvitamin D3 in normal human lymphocytes and the relationship of this protein to the classical vitamin D receptor were examined. Lymphocytes activated with the OKT3 antibody to the T-cell antigen receptor expressed fewer binding sites as compared to lymphocytes that were activated by the polyclonal activator phytohemagglutinin (PHA). However, combination of OKT3 and phorbol myristate acetate produced a concentration of binding sites similar to the PHA-activated cells. The receptor from OKT3 and OKT3 + phorbol myristate acetate-activated lymphocytes exhibited decreased binding to DNA-cellulose compared to PHA-activated lymphocytes. In lymphocytes activated either by PHA or OKT3 (but not in resting cells), a 50-kDa species cross-reacting with a monoclonal antibody against the intestinal vitamin D receptor was detected. Finally, RNA from activated lymphocytes was amplified by polymerase chain reaction using oligonucleotide primers flanking the 196 base pair long region encoding the DNA-binding domain of the human intestinal receptor. The amplified product showed an identical nucleotide sequence to the DNA-binding domain of the human intestinal receptor. These findings suggest that expression of the 1,25-(OH)2D3 receptor in lymphocytes is triggered by distinct and contingent signals, and that the protein and the mRNA encoding it are identical to the classical vitamin D receptor. JF - The Journal of biological chemistry AU - Yu, X P AU - Mocharla, H AU - Hustmyer, F G AU - Manolagas, S C AD - Section of Endocrinology and Metabolism, Veterans Administration Medical Center, Indianapolis, Indiana 46202. Y1 - 1991/04/25/ PY - 1991 DA - 1991 Apr 25 SP - 7588 EP - 7595 VL - 266 IS - 12 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - Phytohemagglutinins KW - Receptors, Calcitriol KW - Receptors, Steroid KW - DNA KW - 9007-49-2 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Humans KW - Phytohemagglutinins -- pharmacology KW - Lymphocyte Activation KW - Polymerase Chain Reaction KW - Base Sequence KW - Blotting, Western KW - Chromatography, Liquid KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Flow Cytometry KW - Female KW - Male KW - DNA -- genetics KW - Receptors, Steroid -- metabolism KW - Lymphocytes -- metabolism KW - Calcitriol -- metabolism KW - Receptors, Steroid -- genetics KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80523531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Vitamin+D+receptor+expression+in+human+lymphocytes.+Signal+requirements+and+characterization+by+western+blots+and+DNA+sequencing.&rft.au=Yu%2C+X+P%3BMocharla%2C+H%3BHustmyer%2C+F+G%3BManolagas%2C+S+C&rft.aulast=Yu&rft.aufirst=X&rft.date=1991-04-25&rft.volume=266&rft.issue=12&rft.spage=7588&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-29 N1 - Date created - 1991-05-29 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M65208; GENBANK; M60204; M60203; M60205; M60206; M62780; M60256; M60257; M60258; M60259 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. AN - 80561841; 2031940 AB - Recent studies have shown that epidermal cholesterol synthesis is regulated by HMG CoA reductase activity and that this activity is modulated by changes in the cutaneous permeability barrier. Here, we quantitated HMG CoA reductase activity after acute and chronic barrier disruption in the upper and lower layers of murine epidermis. In unperturbed epidermis, 13 and 87% of enzyme activity localized to the upper and lower epidermis, respectively, with the majority of activity in the stratum basale. Acute barrier disruption with either acetone or sodium dodecylsulfate provoked an increase in HMG CoA reductase activity (54% and 30%) in the lower layers, but only a small change in the upper layers. However, the activation state of the enzyme was increased 50% in the upper epidermis. Correction of barrier function by occlusion with an impermeable Latex wrap prevented the increase both in enzyme activity and activation state. After chronic barrier disruption; i.e., essential fatty acid deficient (EFAD) diet, HMG CoA reductase activity was increased in the upper epidermis (161%); a change prevented by occlusion. These results show: (1) that HMG CoA reductase activity is present in both the upper and lower cell layers; (2) that acute insults to barrier integrity stimulate enzyme activity in both the upper and lower epidermis; and (3) that chronic insults provoke an increase in enzyme activity in the upper layers. These studies provide further insights into the linkage of the permeability barrier with epidermal cholesterol metabolism. JF - Biochimica et biophysica acta AU - Proksch, E AU - Elias, P M AU - Feingold, K R AD - Metabolism Section, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/04/24/ PY - 1991 DA - 1991 Apr 24 SP - 71 EP - 79 VL - 1083 IS - 1 SN - 0006-3002, 0006-3002 KW - Exfoliatins KW - 0 KW - Cholesterol KW - 97C5T2UQ7J KW - Hydroxymethylglutaryl CoA Reductases KW - EC 1.1.1.- KW - Index Medicus KW - Permeability KW - Animals KW - Reference Values KW - Cholesterol -- biosynthesis KW - Kinetics KW - Microsomes -- enzymology KW - Mice KW - Mice, Hairless KW - Exfoliatins -- toxicity KW - Epidermis -- drug effects KW - Skin -- enzymology KW - Skin -- drug effects KW - Skin -- pathology KW - Epidermis -- pathology KW - Epidermis -- enzymology KW - Hydroxymethylglutaryl CoA Reductases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80561841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Localization+and+regulation+of+epidermal+3-hydroxy-3-methylglutaryl-coenzyme+A+reductase+activity+by+barrier+requirements.&rft.au=Proksch%2C+E%3BElias%2C+P+M%3BFeingold%2C+K+R&rft.aulast=Proksch&rft.aufirst=E&rft.date=1991-04-24&rft.volume=1083&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini. AN - 80522107; 1708286 AB - The mechanisms regulating the net synthesis of digestive enzymes during short-term stimulation by agonists were examined in pancreatic acini isolated from the rat. Dispersed pancreatic acini were stimulated for up to 60 min with various concentrations of cholecystokinin octapeptide (CCK-OP), carbachol, A23187, 4 beta-phorbol 12-myristate 13-acetate (PMA). The effects of these agonists on net protein synthesis was determined by measuring the incorporation of [3H]leucine or [35S]methionine into protein. Carbachol, PMA, A23187 and concentrations of CCK-OP of 100 pM and greater caused inhibition of protein synthesis. Fluorography of [35S]methionine labeled acinar cell proteins separated by one-dimensional SDS-polyacrylamide gel electrophoresis demonstrated that the agonists inhibited the synthesis of the digestive enzymes. Northern blot analysis using cDNA probes revealed that CCK-OP, carbachol and PMA did not alter the cellular content of amylase, lipase and elastase mRNA. The protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) and staurosporine failed to reverse the inhibitory effects of CCK-OP, carbachol and PMA on protein synthesis. CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine. Exogenously added PLA2 (Naja naja venom) inhibited protein synthesis and increased LPC to a similar extent as CCK and PMA. The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation. JF - Biochimica et biophysica acta AU - Perkins, P S AU - Bahrami, L H AU - Lenhard, L W AU - Pandol, S J AD - Department of Medicine, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1991/04/17/ PY - 1991 DA - 1991 Apr 17 SP - 145 EP - 152 VL - 1092 IS - 2 SN - 0006-3002, 0006-3002 KW - Alkaloids KW - 0 KW - DNA Probes KW - Enzymes KW - Isoquinolines KW - Phosphatidylcholines KW - Piperazines KW - Calcimycin KW - 37H9VM9WZL KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Carbachol KW - 8Y164V895Y KW - Protein Kinase C KW - EC 2.7.11.13 KW - Lipase KW - EC 3.1.1.3 KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Amylases KW - EC 3.2.1.- KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Staurosporine KW - H88EPA0A3N KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Pancreatic Elastase -- biosynthesis KW - Electrophoresis, Polyacrylamide Gel KW - Phosphatidylcholines -- metabolism KW - Calcimycin -- pharmacology KW - Nucleic Acid Hybridization KW - Pancreatic Elastase -- genetics KW - Piperazines -- pharmacology KW - Sincalide -- pharmacology KW - Rats KW - Phospholipases A -- pharmacology KW - Enzyme Activation -- drug effects KW - Alkaloids -- pharmacology KW - Amylases -- biosynthesis KW - Phospholipases A -- metabolism KW - Amylases -- genetics KW - Rats, Inbred Strains KW - Isoquinolines -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Lipase -- biosynthesis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lipase -- genetics KW - Carbachol -- pharmacology KW - Pancreas -- enzymology KW - Enzymes -- biosynthesis KW - Pancreas -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80522107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Intracellular+mechanisms+involved+in+short-term+regulation+of+net+protein+synthesis+in+pancreatic+acini.&rft.au=Perkins%2C+P+S%3BBahrami%2C+L+H%3BLenhard%2C+L+W%3BPandol%2C+S+J&rft.aulast=Perkins&rft.aufirst=P&rft.date=1991-04-17&rft.volume=1092&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of transforming growth factor-beta and IL-1 alpha on prostaglandin synthesis in serum-deprived osteoblastic cells. AN - 80514147; 1707913 AB - We investigated the effects that the combination of IL-1 alpha and transforming growth factor-beta (TGF-beta) had on PGE2 production in a murine clonal osteoblastic cell line MC3T3-E1 and primary rat calvarial osteoblast-like cells. In serum-supplemented medium, IL-1 alpha was a potent stimulator of PGE2 production in MC3T3-E1 cells (50-fold increase with 0.1 ng/ml). TGF-beta (10 ng/ml) had only a small effect alone and no additional effect on IL-1 alpha-induced responses. In serum-deprived MC3T3-E1 cells, PGE2 responses to IL-1 alpha were either absent or markedly reduced. TGF-beta alone had small effects. However, simultaneous addition of TGF-beta with IL-1 alpha to MC3T3-E1 cells partially restored the ability of IL-1 alpha to generate a PGE2 response (10-fold increase in PGE2 with 0.1 ng/ml of both IL-1 alpha and TGF-beta). As with MC3T3-E1 cells, serum-deprived primary fetal rat calvarial osteoblastic cells also did not respond to IL-1 alpha, unless TGF-beta was present in the medium (sixfold increase in PGE2 with 0.1 ng/ml IL-1 alpha and 10 ng/ml TGF-beta). The synergistic effect of TGF-beta and IL-1 alpha was specific for PGE2 responses, because these factors did not synergistically affect cell proliferation, collagen and noncollagen protein synthesis, or alkaline phosphatase activity. The observed synergy was not associated with changes in the steady state cyclooxygenase (PGH synthase) mRNA levels. However, it did correlate with increased release of [3H]arachidonic acid from prelabeled serum-depleted MC3T3-E1 cells. Hence, the synergistic interactions of IL-1 alpha and TGF-beta on PGE2 appear to occur through an increase in the release of arachidonic acid substrate from phospholipid pools. These effects may be important for both normal bone turnover and the responses of bone to inflammatory and immune stimuli. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Marusić, A AU - Kalinowski, J F AU - Harrison, J R AU - Centrella, M AU - Raisz, L G AU - Lorenzo, J A AD - Veterans Administration Medical Center, Newington, CT 06111. Y1 - 1991/04/15/ PY - 1991 DA - 1991 Apr 15 SP - 2633 EP - 2638 VL - 146 IS - 8 SN - 0022-1767, 0022-1767 KW - Arachidonic Acids KW - 0 KW - Culture Media KW - Interleukin-1 KW - Transforming Growth Factor beta KW - Arachidonic Acid KW - 27YG812J1I KW - RNA KW - 63231-63-0 KW - Collagen KW - 9007-34-5 KW - DNA KW - 9007-49-2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Dose-Response Relationship, Drug KW - RNA -- analysis KW - Mice KW - Collagen -- biosynthesis KW - DNA -- biosynthesis KW - Arachidonic Acids -- biosynthesis KW - Cells, Cultured KW - Alkaline Phosphatase -- analysis KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Drug Synergism KW - Time Factors KW - Osteoblasts -- metabolism KW - Transforming Growth Factor beta -- pharmacology KW - Interleukin-1 -- pharmacology KW - Dinoprostone -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80514147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Effects+of+transforming+growth+factor-beta+and+IL-1+alpha+on+prostaglandin+synthesis+in+serum-deprived+osteoblastic+cells.&rft.au=Marusi%C4%87%2C+A%3BKalinowski%2C+J+F%3BHarrison%2C+J+R%3BCentrella%2C+M%3BRaisz%2C+L+G%3BLorenzo%2C+J+A&rft.aulast=Marusi%C4%87&rft.aufirst=A&rft.date=1991-04-15&rft.volume=146&rft.issue=8&rft.spage=2633&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-21 N1 - Date created - 1991-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hippocampal mossy fiber zinc deficit in mice genetically selected for ethanol withdrawal seizure susceptibility. AN - 80710020; 1860062 AB - Hippocampal mossy fiber zinc was examined in mice selectively bred for differences in susceptibility to handling-induced convulsions during ethanol withdrawal. The density of mossy fiber zinc in the CA3 stratum lucidum was significantly decreased in the duplicate lines of untreated withdrawal seizure prone (WSP) mice compared to untreated withdrawal seizure resistant (WSR) mice. Mossy fiber zinc densities in randomly bred control lines of mice (WSC) were intermediate to WSP and WSR mice. Serum, whole brain and whole hippocampal zinc were not significantly different between WSP and WSR mice, indicating that the reduction in the chelatable pool of hippocampal mossy fiber zinc was not a consequence of deficits in brain or whole body zinc nutrition. A highly significant correlation between hippocampal mossy fiber zinc density and handling-induced convulsion indices suggests that a reduction in mossy fiber zinc may be one contributing factor in the expression of seizure susceptibility in WSP mice. JF - Brain research AU - Feller, D J AU - Tso-Olivas, D Y AU - Savage, D D AD - Veterans Administration Medical Center, Portland, OR 97201. Y1 - 1991/04/05/ PY - 1991 DA - 1991 Apr 05 SP - 73 EP - 79 VL - 545 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Ethanol KW - 3K9958V90M KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Handling (Psychology) KW - Animals KW - Brain Chemistry KW - Mice, Neurologic Mutants KW - Organ Specificity KW - Mice KW - Zinc -- analysis KW - Substance Withdrawal Syndrome -- physiopathology KW - Seizures -- physiopathology KW - Hippocampus -- metabolism KW - Seizures -- genetics KW - Seizures -- pathology KW - Hippocampus -- pathology KW - Hippocampus -- chemistry KW - Zinc -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80710020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Hippocampal+mossy+fiber+zinc+deficit+in+mice+genetically+selected+for+ethanol+withdrawal+seizure+susceptibility.&rft.au=Feller%2C+D+J%3BTso-Olivas%2C+D+Y%3BSavage%2C+D+D&rft.aulast=Feller&rft.aufirst=D&rft.date=1991-04-05&rft.volume=545&rft.issue=1-2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypertrophic smooth muscle in the partially obstructed opossum esophagus. The model: histological and ultrastructural observations. AN - 85245637; pmid-2001825 AB - Obstruction is a complication of many esophageal diseases, but the morphological changes occurring in the obstructed esophagus are poorly understood. We developed a model of esophageal obstruction in the American opossum, Didelphis virginiana. A nonconstricting band around the gastroesophageal junction led to esophageal distention and tortuosity in the weeks following its placement. Despite a marked increase of the esophageal circumference, the esophageal wall was not thinned, and the circular muscle layer had actually increased its thickness. This was due to an increase in the size of individual smooth muscle cells with proportional increases in the cell surface area and volume. The electron density of hypertrophic smooth muscle cells varied much more than that of normal esophageal smooth muscle cells. As cell size increased, the tissue became more compact and the size of the extracellular space decreased. Also, the extracellular space was filled by an amorphous electron-dense material. Additional changes in the structure of hypertrophic smooth muscle cells included prominent intermediate filaments in the vicinity of thick filaments. There was no difference in the structure of the hypertrophic smooth muscle at 4 weeks and at 8 weeks after placement of the band. The morphological features described here resemble those seen in human esophageal spasm and achalasia of humans and could affect esophageal smooth muscle function. JF - Gastroenterology AU - Tung, H N AU - Schulze-Delrieu, K AU - Shirazi, S AU - Noel, S AU - Xia, Q AU - Cue, K AD - Department of Anatomy, Veterans Administration Medical Center, University of Iowa, Iowa City. PY - 1991 SP - 853 EP - 864 VL - 100 IS - 4 SN - 0016-5085, 0016-5085 KW - Esophagus KW - Hypertrophy KW - Muscle, Smooth KW - Esophageal Stenosis KW - Animal KW - Disease Models, Animal KW - Support, Non-U.S. Gov't KW - Female KW - Male KW - Opossums UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85245637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Hypertrophic+smooth+muscle+in+the+partially+obstructed+opossum+esophagus.+The+model%3A+histological+and+ultrastructural+observations.&rft.au=Tung%2C+H+N%3BSchulze-Delrieu%2C+K%3BShirazi%2C+S%3BNoel%2C+S%3BXia%2C+Q%3BCue%2C+K&rft.aulast=Tung&rft.aufirst=H&rft.date=1991-04-01&rft.volume=100&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Delayed subcapsular hematoma after percutaneous liver biopsy as a manifestation of warfarin toxicity. AN - 85225197; pmid-1849346 AB - Guidelines for the management of patients receiving chronic anticoagulation therapy who require liver biopsy are not clearly defined. In patients with normal coagulation, liver biopsy is a relatively safe procedure with a morbidity of less than 0.1% and a mortality of less than 0.01%. We report a patient with a prosthetic aortic valve who developed a large subcapsular hematoma 12 days after a percutaneous liver biopsy as a consequence of warfarin toxicity. Based on the experience with this patient, reinstitution of anticoagulant therapy should be avoided for at least 72 h after a percutaneous liver biopsy. Intravenous heparin should be resumed first, and warfarin added if no bleeding has occurred after an additional 48-72 h. The prothrombin time should be maintained at 1.5 times the baseline. JF - The American Journal of Gastroenterology AU - Scott, D A AU - Netchvolodoff, C V AU - Bacon, B R AD - Department of Medicine, Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana. PY - 1991 SP - 503 EP - 505 VL - 86 IS - 4 SN - 0002-9270, 0002-9270 KW - Liver Neoplasms KW - Hematoma KW - Liver Diseases KW - Carcinoma, Hepatocellular KW - Human KW - Middle Age KW - Case Report KW - Warfarin KW - Biopsy, Needle KW - Prothrombin Time KW - Time Factors KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Delayed+subcapsular+hematoma+after+percutaneous+liver+biopsy+as+a+manifestation+of+warfarin+toxicity.&rft.au=Scott%2C+D+A%3BNetchvolodoff%2C+C+V%3BBacon%2C+B+R&rft.aulast=Scott&rft.aufirst=D&rft.date=1991-04-01&rft.volume=86&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy. AN - 85223492; pmid-1901443 AB - Valproic acid has been implicated in at least 100 cases of fatal acute liver failure. Most cases have occurred in patients less than 10 yr old; however, at least seven have involved adults. Microvesicular steatosis has been uniformly observed, but its incidence in less severe liver disease and in asymptomatic patients receiving valproate is unknown. We report two patients receiving maintenance valproate, one with resolving acute hepatitis C and the other with chronic persistent hepatitis C, with incidental microvesicular steatosis demonstrated on oil-red O stains. We conclude that microvesicular steatosis does not necessarily signify hepatotoxicity in patients on chronic valproic acid, and should not lead to discontinuation of the drug until other causes of acute or chronic liver disease have been excluded. JF - The American Journal of Gastroenterology AU - Scott, D A AU - Gholson, C F AU - Netchvolodoff, C V AU - Ray, M AU - Gonzalez, E AU - Bacon, B R AD - Department of Medicine, Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana. PY - 1991 SP - 500 EP - 502 VL - 86 IS - 4 SN - 0002-9270, 0002-9270 KW - Hepatitis, Chronic KW - Human KW - Adult KW - Seizures KW - Case Report KW - Fatty Liver KW - Hepatitis C KW - Valproic Acid KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Incidental+microvesicular+steatosis+due+to+valproic+acid+anticonvulsant+therapy.&rft.au=Scott%2C+D+A%3BGholson%2C+C+F%3BNetchvolodoff%2C+C+V%3BRay%2C+M%3BGonzalez%2C+E%3BBacon%2C+B+R&rft.aulast=Scott&rft.aufirst=D&rft.date=1991-04-01&rft.volume=86&rft.issue=4&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Facial nerve and medially invasive petrous bone cholesteatomas. AN - 85176991; pmid-2018289 AB - Eight patients with extensive petrous bone cholesteatomas that invaded the labyrinth and fallopian canal are presented. The eight cases are added to a tabulation of prior literature reports to elucidate concepts of routes of extension of medially invasive temporal bone cholesteatoma. Medially invasive petrous bone cholesteatoma develops insidiously, often without symptoms other than facial palsy and/or unilateral deafness. Typically, a history of chronic ear disease can be obtained. While hearing is unlikely to be preserved in this group of patients, facial nerve function can usually be preserved, and a facial nerve graft was not necessary in our series. Acute facial nerve palsy or facial nerve paresis progressing to palsy in patients with a history of chronic ear disease should be studied radiographically for petrous bone cholesteatoma, even if there is no physical evidence of cholesteatoma. JF - The Annals of Otology, Rhinology, and Laryngology AU - Bartels, L J AD - Department of Surgery, University of South Florida, James Haley Veterans Administration Hospital, Tampa 33612. PY - 1991 SP - 308 EP - 316 VL - 100 IS - 4 Pt 1 SN - 0003-4894, 0003-4894 KW - Humans KW - Adult KW - Petrous Bone KW - Aged KW - Cholesteatoma KW - Middle Aged KW - Ear Diseases KW - Facial Paralysis KW - Female KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85176991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Facial+nerve+and+medially+invasive+petrous+bone+cholesteatomas.&rft.au=Bartels%2C+L+J&rft.aulast=Bartels&rft.aufirst=L&rft.date=1991-04-01&rft.volume=100&rft.issue=4+Pt+1&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Aluminum alters calcium influx and efflux from bone in vitro. AN - 80617807; 2051717 AB - Aluminum retention can cause osteomalacia and adynamic lesions of bone in patients undergoing long-term dialysis. It is not known, however, whether aluminum inhibits the mineralization of bone directly or whether alterations in osteoblastic function mediate this response. To examine this issue, the uptake of 45Ca by 14-day embryonic chick calvaria was measured in vitro. Comparative studies were done in living and devitalized tissues to evaluate the role of bone cells in aluminum-related changes in 45Ca uptake. Aluminum was added to serum-free media as the citrate complex, and paired hemicalvaria maintained in equimolar sodium citrate served as controls. Aluminum citrate decreased the uptake of 45Ca into bone during 24 hour incubations to 76 +/- 3% and 38 +/- 2% (x +/- SD) of control values at 10 microM and 100 microM aluminum, respectively. No change in 45Ca uptake was observed at the end of four hour incubations with 100 microM aluminum citrate, whereas 45Ca uptake decreased from 356 +/- 48 to 266 +/- 36 cpm/micrograms bone, P less than 0.05, at eight hours and from 327 +/- 22 to 269 +/- 41 cpm/micrograms bone, P less than 0.05, at 24 hours. The inhibitory effects of 10 microM and 100 microM aluminum on 45Ca uptake were eliminated, however, in devitalized tissues, and reductions in 45Ca uptake during incubations with aluminum were markedly attenuated by lowering the media phosphorus level from 4.0 mM to 2.0 mM.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Kidney international AU - Goodman, W G AU - O'Connor, J AD - Medical Service, Sepulveda Veterans Administration Medical Center, California. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 602 EP - 607 VL - 39 IS - 4 SN - 0085-2538, 0085-2538 KW - Aluminum KW - CPD4NFA903 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Osteoblasts -- metabolism KW - Osteoblasts -- drug effects KW - Biological Transport, Active -- drug effects KW - Animals KW - Chick Embryo KW - In Vitro Techniques KW - Calcium -- metabolism KW - Bone and Bones -- drug effects KW - Aluminum -- toxicity KW - Bone and Bones -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80617807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Aluminum+alters+calcium+influx+and+efflux+from+bone+in+vitro.&rft.au=Goodman%2C+W+G%3BO%27Connor%2C+J&rft.aulast=Goodman&rft.aufirst=W&rft.date=1991-04-01&rft.volume=39&rft.issue=4&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic inhibition potentiates oxidant injury. AN - 80526949; 2020185 AB - Toxic oxygen species have been implicated as important mediators of injury after reperfusion of an ischemic organ. The aim of this study was to determine if prior metabolic inhibition, such as that which occurs during ischemia, potentiates oxidant injury in vitro. Bovine pulmonary artery endothelial cells were metabolically inhibited for various periods of time with or without the mitochondrial inhibitor oligomycin (650 nM). The cells were rescued from metabolic inhibition by a wash step and subsequent addition of 5.5 mM glucose. At the same time that metabolic inhibition was relieved the cells were subjected to doses of H2O2 ranging from 0 to 100 microM. ATP levels were monitored over a 2-hr time course after rescue from metabolic inhibition by the luciferin-luciferase assay. Cell viability at 2 hr after relief of metabolic inhibition was assessed by trypan blue exclusion. Intracellular pH during metabolic inhibition was determined with the fluorescent dye 2',7'-bis-(2-carboxyethyl)-5(and-6) carboxyfluorescein tetraacetomethoxymethyl ester. H2O2 consumption, a measure of H2O2 scavenging capability, was determined by a fluorescent assay. The viability and ATP levels of cells not subjected to metabolic inhibition were unaffected by these low concentrations of H2O2. Cells metabolically inhibited with glucose depletion and oligomycin were exquisitely sensitive to H2O2. Cells that were only deprived of glucose demonstrated no potentiation of injury, while cells subjected to mitochondrial inhibition with oligomycin alone also showed significant potentiation of oxidant injury. H2O2 consumption was not affected by metabolic inhibition. Conditions associated with mitochondrial inhibition consistently resulted in a decrease in intracellular pH. These experiments suggest that a synergism exists between metabolic inhibition and subsequent oxidant exposure.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of surgical research AU - Delius, R E AU - Hinshaw, D B AD - Surgical Service, Ann Arbor Veterans Administration Medical Center, MI 48105. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 314 EP - 322 VL - 50 IS - 4 SN - 0022-4804, 0022-4804 KW - Oligomycins KW - 0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glucose KW - IY9XDZ35W2 KW - Potassium Cyanide KW - MQD255M2ZO KW - Index Medicus KW - Animals KW - Cattle KW - Endothelium, Vascular -- metabolism KW - Hydrogen-Ion Concentration KW - Hydrogen Peroxide -- metabolism KW - Glucose -- metabolism KW - In Vitro Techniques KW - Adenosine Triphosphate -- metabolism KW - Oligomycins -- pharmacology KW - Models, Biological KW - Potassium Cyanide -- pharmacology KW - Cell Survival KW - Reperfusion Injury -- metabolism KW - Ischemia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80526949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Metabolic+inhibition+potentiates+oxidant+injury.&rft.au=Delius%2C+R+E%3BHinshaw%2C+D+B&rft.aulast=Delius&rft.aufirst=R&rft.date=1991-04-01&rft.volume=50&rft.issue=4&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of surfactant subtype convertase in radiation model of adult respiratory distress syndrome. AN - 80518824; 2018151 AB - The accompanying paper [Am. J. Physiol. 260 (Lung Cell. Mol. Physiol. 4): L302-L310, 1991] showed that in the radiation pneumonitis model of adult respiratory distress syndrome (ARDS) there was an excess of the proximate, higher buoyant density subtypes of alveolar surfactant, and a decrease in the light buoyant density form. Because the surfactant subtypes normally evolve from the former to the latter a delay in the alveolar metabolism of surfactant could explain this disproportion. Three possible mechanisms of a delay in surfactant metabolism in radiation pneumonitis were explored using an in vitro model of surfactant subtype metabolism called "cycling". The first was that the surfactant of mice with radiation pneumonitis was intrinsically less capable of conversion to the light subtype. It was found, however, that the proximate forms of surfactant of mice with radiation pneumonitis were as capable of generating light subtype as those of control mice. The second was that there was a deficit in the serine protease activity, called "convertase", that mediates the conversion. But it was found that lungs of mice with radiation pneumonitis released convertase activity to the same extent as control lungs. The third was that an inhibitor of convertase activity was present in the alveoli. It was found that the alveolar lavage fluid of mice with radiation pneumonitis inhibited the conversion of exogenous surfactant by exogenous convertase. Moreover, it contained an 18-fold excess of antiprotease activity. The present data are interpreted as suggesting that an inhibitor in the alveolar space is responsible for the delay in surfactant subtype metabolism in radiation pneumonitis, resulting in the disproportion of surfactant subtypes in radiation pneumonitis.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of physiology AU - Gross, N J AD - Medical Service, Hines Veterans Administration Hospital 60141. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - L311 EP - L317 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Pulmonary Surfactants KW - 0 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - surfactant subtype convertase KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Therapeutic Irrigation KW - Mice KW - Female KW - Respiratory Distress Syndrome, Adult -- metabolism KW - Pulmonary Surfactants -- metabolism KW - Pulmonary Surfactants -- isolation & purification KW - Radiation Injuries, Experimental -- metabolism KW - Serine Endopeptidases -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Pulmonary Surfactants -- classification KW - Respiratory Distress Syndrome, Adult -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80518824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Inhibition+of+surfactant+subtype+convertase+in+radiation+model+of+adult+respiratory+distress+syndrome.&rft.au=Gross%2C+N+J&rft.aulast=Gross&rft.aufirst=N&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=L311&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surfactant subtypes in experimental lung damage: radiation pneumonitis. AN - 80516427; 2018150 AB - Radiation pneumonitis, a chronic form of adult respiratory distress syndrome (ARDS), is known to be associated with physiological and biophysical abnormalities of the surface element of the lungs suggesting an impairment of the surfactant system. The alveolar surfactant of mice with radiation pneumonitis was fractionated into subtypes on continuous sucrose density gradients to examine their relative amounts, composition, ultrastructure, surface activity, and turnover kinetics. The total phospholipid and protein contents of the alveolar lavage were increased. The proportions of high buoyant density subtypes (normally surface active) were increased about twofold and that of the low buoyant density subtype (not surface active) was decreased or absent. The buoyant densities, ultrastructure, and phospholipid compositions of the major surfactant subtypes were not significantly altered. The surface activity of the normally surface-active subtypes, when purified free of extraneous material, was close to those of normal controls. Turnover studies of the kinetics of surfactant subtype phospholipids suggested increased secretion of surfactant but a delay in the conversion of the heavier subtypes into their low-density product. Most of the heavier material appeared not to enter the lighter pool, in contrast to findings in control mice. It is concluded that in this form of ARDS the surfactant subtypes are qualitatively normal but that their surface activity is impaired, presumably by extraneous material in the alveoli, and that proportions of surfactant subtypes are radically altered by a combination of increased synthesis and decreased metabolism of the heavier subtypes. JF - The American journal of physiology AU - Gross, N J AD - Medical Service, Hines Veterans Administration Hospital 60141. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - L302 EP - L310 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Cobalt Radioisotopes KW - 0 KW - Phospholipids KW - Pulmonary Surfactants KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Phospholipids -- radiation effects KW - Phospholipids -- isolation & purification KW - Therapeutic Irrigation KW - Phospholipids -- classification KW - Disease Models, Animal KW - Microscopy, Electron KW - Mice KW - Female KW - Radiation Injuries, Experimental -- pathology KW - Pulmonary Surfactants -- isolation & purification KW - Pulmonary Alveoli -- ultrastructure KW - Pulmonary Alveoli -- chemistry KW - Lung -- ultrastructure KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Respiratory Distress Syndrome, Adult -- pathology KW - Lung -- pathology KW - Radiation Injuries, Experimental -- physiopathology KW - Lung -- physiopathology KW - Respiratory Distress Syndrome, Adult -- etiology KW - Pulmonary Alveoli -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80516427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Surfactant+subtypes+in+experimental+lung+damage%3A+radiation+pneumonitis.&rft.au=Gross%2C+N+J&rft.aulast=Gross&rft.aufirst=N&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=L302&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transferrin enhances the antiproliferative effect of aluminum on osteoblast-like cells. AN - 80515966; 2018119 AB - Aluminum (Al) retention in the body can cause metabolic bone disease. This disorder is characterized by reductions in the number of osteoblasts, a feature that suggests a disturbance in bone cell proliferation or differentiation. Because Al as well as iron (Fe) can bind to transferrin (TF) in plasma, the role of TF as a modifier of osteoblast proliferation was examined in UMR-106-01 osteoblast-like cells by measuring the incorporation of tritiated thymidine ([3H]-TdR) into DNA (counts.min-1.microgram cell protein-1, means +/- SE) during 48-h incubations in serum-free medium (SFM). In the absence of TF, DNA synthesis decreased when media levels of Al exceeded 6-10 microM. The mitogenic response to physiological levels of unsaturated TF (apo-TF) was attenuated however during incubations with TF that was partially saturated with Al (Al-TF). A similar inhibitory response was seen in cells incubated with the antiproliferative agent gallium (Ga) when added to SFM as partially saturated Ga-TF. TF produced a shift to the left in the inhibitory dose-response curve to Al in osteoblast-like cells; thus, DNA synthesis decreased at substantially lower media concentrations of Al in cells grown in SFM containing partially saturated Al-TF. The results indicate that TF is an important determinant of the inhibitory effect of Al on DNA synthesis by osteoblast-like cells at the micromolar levels of Al that can occur in plasma in vivo. JF - The American journal of physiology AU - Kasai, K AU - Hori, M T AU - Goodman, W G AD - Medical Service, Sepulveda Veterans Administration Medical Center 91343. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - E537 EP - E543 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Apoproteins KW - 0 KW - Citrates KW - Transferrin KW - apotransferrin KW - Tritium KW - 10028-17-8 KW - Citric Acid KW - 2968PHW8QP KW - Gallium KW - CH46OC8YV4 KW - Aluminum KW - CPD4NFA903 KW - Iron KW - E1UOL152H7 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Animals KW - Apoproteins -- pharmacology KW - Iron -- pharmacology KW - Osteosarcoma KW - Rats KW - Thymidine -- metabolism KW - Gallium -- pharmacology KW - Kinetics KW - Sarcoma, Experimental KW - Drug Synergism KW - Cell Line KW - Osteoblasts -- drug effects KW - Aluminum -- pharmacology KW - Cell Division -- drug effects KW - Transferrin -- pharmacology KW - Citrates -- pharmacology KW - DNA Replication -- drug effects KW - Osteoblasts -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80515966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Transferrin+enhances+the+antiproliferative+effect+of+aluminum+on+osteoblast-like+cells.&rft.au=Kasai%2C+K%3BHori%2C+M+T%3BGoodman%2C+W+G&rft.aulast=Kasai&rft.aufirst=K&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=E537&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory gastropathy: from theory to practice. AN - 80499013; 2012116 AB - The success of nonsteroidal anti-inflammatory drugs in managing joint inflammation and pain has come at the cost of impressive side effects, particularly in the gastrointestinal tract. This manuscript reviews the magnitude of the problem, the risk factors, and presentation of nonsteroidal gastropathy. It also presents some points in the prevention and management of the disorder. JF - The American journal of the medical sciences AU - Balaa, M A AD - Veterans Administration Medical Center, Jackson, Mississippi. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 272 EP - 276 VL - 301 IS - 4 SN - 0002-9629, 0002-9629 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Prostaglandin Antagonists KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Age Factors KW - Prostaglandin Antagonists -- adverse effects KW - Humans KW - Gastric Mucosa -- drug effects KW - Stomach Diseases -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Stomach Diseases -- therapy KW - Stomach Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80499013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Nonsteroidal+anti-inflammatory+gastropathy%3A+from+theory+to+practice.&rft.au=Balaa%2C+M+A&rft.aulast=Balaa&rft.aufirst=M&rft.date=1991-04-01&rft.volume=301&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-03 N1 - Date created - 1991-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diphenylhydantoin-induced hypogammaglobulinemia in a patient infected with human immunodeficiency virus. AN - 80498859; 2012095 AB - A case is reported of reversible panhypogammaglobulinemia in a human immunodeficiency virus (HIV)-infected patient. Onset and resolution were temporally correlated with initiation and termination, respectively, of diphenylhydantoin therapy for a possible seizure. A rapid alteration in peripheral T-cell subpopulations was also noted in association with diphenylhydantoin administration. This case is compared with previous reports of diphenylhydantoin-associated hypogammaglobulinemia in non-HIV-infected patients. In addition, the case is discussed with regard to possible deleterious effects associated with the use of diphenylhydantoin as therapy for HIV-associated seizures or as an antiretroviral agent in HIV disease. JF - The American journal of medicine AU - Britigan, B E AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 524 EP - 527 VL - 90 IS - 4 SN - 0002-9343, 0002-9343 KW - Phenytoin KW - 6158TKW0C5 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Hepatitis B -- complications KW - Seizures -- complications KW - Humans KW - Adult KW - Seizures -- drug therapy KW - Homosexuality KW - Liver Function Tests KW - Male KW - Agammaglobulinemia -- chemically induced KW - Agammaglobulinemia -- physiopathology KW - Agammaglobulinemia -- complications KW - Phenytoin -- adverse effects KW - HIV Seropositivity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80498859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Diphenylhydantoin-induced+hypogammaglobulinemia+in+a+patient+infected+with+human+immunodeficiency+virus.&rft.au=Britigan%2C+B+E&rft.aulast=Britigan&rft.aufirst=B&rft.date=1991-04-01&rft.volume=90&rft.issue=4&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-09 N1 - Date created - 1991-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic use of acebutolol in the treatment of cardiac arrhythmias. AN - 80492160; 2008843 JF - American heart journal AU - O'Reilly, M AD - Cardiology Section, Veterans Administration Medical Center, Wilkes-Barre, PA 18711. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 1185 EP - 1193 VL - 121 IS - 4 Pt 1 SN - 0002-8703, 0002-8703 KW - Acebutolol KW - 67P356D8GH KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Chronic Disease KW - Acebutolol -- administration & dosage KW - Arrhythmias, Cardiac -- drug therapy KW - Acebutolol -- therapeutic use KW - Acebutolol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80492160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Chronic+use+of+acebutolol+in+the+treatment+of+cardiac+arrhythmias.&rft.au=O%27Reilly%2C+M&rft.aulast=O%27Reilly&rft.aufirst=M&rft.date=1991-04-01&rft.volume=121&rft.issue=4+Pt+1&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-02 N1 - Date created - 1991-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - COPD exacerbation associated with a skin rash. AN - 80489697; 1826252 JF - Chest AU - Marshall, J AU - Altman, D AU - Lauber, M AU - Baylor, P AD - Veterans Administration Medical Center, Fresno, CA. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 1016 EP - 1017 VL - 99 IS - 4 SN - 0012-3692, 0012-3692 KW - Cimetidine KW - 80061L1WGD KW - Abridged Index Medicus KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Aged KW - Cimetidine -- adverse effects KW - Male KW - Drug Eruptions -- diagnosis KW - Strongyloidiasis -- complications KW - Strongyloidiasis -- diagnosis KW - Larva Migrans -- diagnosis KW - Lung Diseases, Obstructive -- complications KW - Larva Migrans -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80489697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=COPD+exacerbation+associated+with+a+skin+rash.&rft.au=Marshall%2C+J%3BAltman%2C+D%3BLauber%2C+M%3BBaylor%2C+P&rft.aulast=Marshall&rft.aufirst=J&rft.date=1991-04-01&rft.volume=99&rft.issue=4&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-06 N1 - Date created - 1991-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Precautions prevent spread of Creutzfeldt-Jakob disease. AN - 72050039; 1831471 AB - Currently some experts are predicting the incidence of the rare yet rapidly fatal Creutzfeldt-Jakob disease (CJD) is on the rise. Worldwide, there is about one case per million people per year, but iatrogenic transmission is increasing. There have been documented cases of CJD transmission through corneal transplants, stereotactic equipment, human growth hormone and dura mater grafts. In addition, there are now three cases of laboratory workers with CJD from exposure in the workplace. No known treatment alters the relentless course of CJD and there is no vaccine. In every rapidly progressive unexplained dementia CJD must remain a diagnostic possibility. Because the etiologic agent is virulent, definition of necessary precautions for staff members associated with such patients is needed. Thus it is imperative medical personnel be well trained in the practice of universal precautions. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Mocsny, N AD - Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 116 EP - 119 VL - 23 IS - 2 SN - 0888-0395, 0888-0395 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Nursing Staff, Hospital KW - Occupational Diseases -- prevention & control KW - Creutzfeldt-Jakob Syndrome -- transmission KW - Occupational Diseases -- etiology KW - Creutzfeldt-Jakob Syndrome -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72050039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Precautions+prevent+spread+of+Creutzfeldt-Jakob+disease.&rft.au=Mocsny%2C+N&rft.aulast=Mocsny&rft.aufirst=N&rft.date=1991-04-01&rft.volume=23&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sexual Interest, Activity, and Satisfaction among Male Nursing Home Residents AN - 61236201; 91X9422 AB - Structured interviews completed with 61 male residents, 30 of whom had partners, of a Veterans Affairs Nursing Home are used to investigate sexual interest, preference, activity levels, satisfaction, & distress. Sexual interest was significantly higher among those with partners, although those without partners reported that their interest would have been higher if they had a sexual partner. Sexual preference was strongly in favor of vaginal intercourse, regardless of the presence or absence of a partner. Among those with partners, coitus was reported to occur at least monthly by 17%, & other forms of sexual activity (eg, hugging, kissing) were practiced at least monthly by 73%. Sexual satisfaction was high, & distress with relative sexual inactivity was remarkably low. Findings reveal that age, functional status, & intercourse frequency correlate positively with sexual satisfaction, whereas marital status, cognitive function, libido, & frequency of kissing were positive correlates of sexual distress. Institutionalized elderly males remain sexually interested, especially in coitus, & may benefit from counseling & home visits when a partner is available. 1 Table, 7 References. Adapted from the source document. JF - Archives of Sexual Behavior AU - Mulligan, Thomas AU - Palguta, Robert F, Jr AD - Veterans Administration Medical Center, Broad Rock Rd Richmond VA 23249 Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 199 EP - 204 VL - 20 IS - 2 SN - 0004-0002, 0004-0002 KW - sexual interest/preference/activity/satisfaction/distress, male Veterans Affairs Nursing Home residents KW - interviews KW - Sexual Behavior KW - Satisfaction KW - Males KW - Elderly KW - Nursing Homes KW - article KW - 2143: social problems and social welfare; social gerontology KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61236201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Sexual+Interest%2C+Activity%2C+and+Satisfaction+among+Male+Nursing+Home+Residents&rft.au=Mulligan%2C+Thomas%3BPalguta%2C+Robert+F%2C+Jr&rft.aulast=Mulligan&rft.aufirst=Thomas&rft.date=1991-04-01&rft.volume=20&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASXBA8 N1 - SubjectsTermNotLitGenreText - Elderly; Males; Nursing Homes; Sexual Behavior; Satisfaction ER - TY - JOUR T1 - Alternate Form of the California Verbal Learning Test: Development and Reliability AN - 58219944; 9202110 AB - A parallel form of the California Verbal Learning Test (CVLT) was developed & compared with the original (N = 41 normal adults). The two CVLT forms yielded equivalent mean scores for the 19 learning & memory variables analyzed. Order of administration of the two forms did not produce any significant practice effects. They both yielded almost identical relationships between overall memory performance & age & education. Sixteen of the variables resulted in significant alternate form reliability coefficients. Coefficients for the traditional recall measures were particularly robust & higher than those reported for other commonly used clinical memory tests. 2 Tables, 35 References. Adapted from the source document JF - The Clinical Neuropsychologist AU - Delis, Dean C AU - McKee, Richard AU - Massman, Paul J AU - Kramer, Joel H AU - Kaplan, Edith AU - Gettman, Dennis AD - Psychology Service Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 154 EP - 162 VL - 5 IS - 2 SN - 1385-4046, 1385-4046 KW - California Verbal Learning Test parallel alternative form development/comparison/reliability KW - empirical testing KW - normal adults KW - Retention (Memory) (73150) KW - Test Validity and Reliability (88800) KW - Adults (00600) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58219944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Alternate+Form+of+the+California+Verbal+Learning+Test%3A+Development+and+Reliability&rft.au=Delis%2C+Dean+C%3BMcKee%2C+Richard%3BMassman%2C+Paul+J%3BKramer%2C+Joel+H%3BKaplan%2C+Edith%3BGettman%2C+Dennis&rft.aulast=Delis&rft.aufirst=Dean&rft.date=1991-04-01&rft.volume=5&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Test Validity and Reliability (88800); Adults (00600); Retention (Memory) (73150) ER - TY - JOUR T1 - Diminished glucose transport in Alzheimer's disease: dynamic PET studies. AN - 85274497; pmid-1997504 AB - Dynamic positron emission tomography with [18F]fluorodeoxyglucose was used in six patients with Alzheimer's disease (AD) and seven healthy age-matched control subjects to estimate the kinetic parameters K1*, k2*, and k3* that describe glucose transport and phosphorylation. A high-resolution tomograph was used to acquire brain uptake data in one tomographic plane, and a radial artery catheter connected to a plastic scintillator was used to acquire arterial input data. A nonlinear iterative least-squares fitting procedure that included terms for the vascular fraction and time delay to the peripheral sampling site was used to fit a three-compartment model to the brain data. Regions studied included frontal, temporal, occipital, and the entire cortex and subcortical white matter. The values obtained for the individual rate constants and regional CMRglc (rCMRglc; calculated using regional values of the rate constants) were higher than those reported previously. A significant (p less than 0.05) decrease was found in K1* in frontal and temporal cortex in the AD patients compared with the controls, with values of 0.157 and 0.161 ml/g/min in frontal and temporal cortex, respectively, of controls and 0.127 and 0.126 ml/g/min in frontal and temporal cortex of the AD patients. rCMRglc was also significantly (p less than 0.02) lower in the AD patients than controls in all cortical brain regions. Lower values of k3* were found in all brain regions in the AD patients, although these were not statistically significant. These findings provide evidence of an in vivo abnormality of forward glucose transport in AD.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of Cerebral Blood Flow and Metabolism AU - Jagust, W J AU - Seab, J P AU - Huesman, R H AU - Valk, P E AU - Mathis, C A AU - Reed, B R AU - Coxson, P G AU - Budinger, T F AD - Department of Neurology, Martinez Veterans Administration Medical Center, California. PY - 1991 SP - 323 EP - 330 VL - 11 IS - 2 SN - 0271-678X, 0271-678X KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Alzheimer Disease KW - Biological Transport KW - Brain KW - Glucose KW - Aged KW - Cerebral Cortex KW - Frontal Lobe KW - Phosphorylation KW - Fludeoxyglucose F 18 KW - Kinetics KW - Fluorine Radioisotopes KW - Temporal Lobe KW - Middle Age KW - Deoxyglucose KW - Support, U.S. Gov't, Non-P.H.S. KW - Tomography, Emission-Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85274497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Diminished+glucose+transport+in+Alzheimer%27s+disease%3A+dynamic+PET+studies.&rft.au=Jagust%2C+W+J%3BSeab%2C+J+P%3BHuesman%2C+R+H%3BValk%2C+P+E%3BMathis%2C+C+A%3BReed%2C+B+R%3BCoxson%2C+P+G%3BBudinger%2C+T+F&rft.aulast=Jagust&rft.aufirst=W&rft.date=1991-03-01&rft.volume=11&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Epithelioid angiosarcoma of the adrenal gland associated with chronic arsenical intoxication? AN - 80672088; 2068012 AB - Epithelioid angiosarcoma is a rare tumor quite recently described. There is no accurate epidemiological study of this tumor. Among the internal organs, the liver is the one most frequently affected with angiosarcoma while there is no reference to the adrenal gland as a primary site. It is well known that the direct exposure to arsenicals (especially of vineyard cultivators) may be an important causative factor in the pathogenesis of the disease. A 59-year-old male vineyard cultivator with an epithelioid angiosarcoma of the right adrenal gland is described. The histologic characteristics as well as the immunohistochemical profile of the tumor are presented and the literature is briefly reviewed. JF - Pathology, research and practice AU - Livaditou, A AU - Alexiou, G AU - Floros, D AU - Filippidis, T AU - Dosios, T AU - Bays, D AD - Air Force and Veterans Administration General Hospital, Athens, Greece. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 284 EP - 289 VL - 187 IS - 2-3 SN - 0344-0338, 0344-0338 KW - Insecticides KW - 0 KW - Index Medicus KW - Humans KW - Tomography, X-Ray Computed KW - Middle Aged KW - Epithelium -- pathology KW - Male KW - Insecticides -- poisoning KW - Arsenic Poisoning KW - Agricultural Workers' Diseases -- chemically induced KW - Adrenal Gland Neoplasms -- chemically induced KW - Hemangiosarcoma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80672088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathology%2C+research+and+practice&rft.atitle=Epithelioid+angiosarcoma+of+the+adrenal+gland+associated+with+chronic+arsenical+intoxication%3F&rft.au=Livaditou%2C+A%3BAlexiou%2C+G%3BFloros%2C+D%3BFilippidis%2C+T%3BDosios%2C+T%3BBays%2C+D&rft.aulast=Livaditou&rft.aufirst=A&rft.date=1991-03-01&rft.volume=187&rft.issue=2-3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Pathology%2C+research+and+practice&rft.issn=03440338&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heparin-induced hyperkalemia. AN - 80669267; 2067368 JF - Journal of the Tennessee Medical Association AU - Margolies, G AD - Nashville Veterans Administration Hospital. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 126 VL - 84 IS - 3 SN - 0040-3318, 0040-3318 KW - Heparin KW - 9005-49-6 KW - Aspirin KW - R16CO5Y76E KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Drug Therapy, Combination KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Humans KW - Potassium -- blood KW - Aged KW - Male KW - Cerebral Infarction -- blood KW - Hyperkalemia -- blood KW - Heparin -- administration & dosage KW - Cerebral Infarction -- drug therapy KW - Hyperkalemia -- chemically induced KW - Heparin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80669267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Tennessee+Medical+Association&rft.atitle=Heparin-induced+hyperkalemia.&rft.au=Margolies%2C+G&rft.aulast=Margolies&rft.aufirst=G&rft.date=1991-03-01&rft.volume=84&rft.issue=3&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Tennessee+Medical+Association&rft.issn=00403318&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-09 N1 - Date created - 1991-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol and drug abuse prevention in adolescents. AN - 80648004; 2058809 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 308 VL - 15 IS - 2 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Self Concept KW - Adaptation, Psychological KW - Risk Factors KW - Humans KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Health Education -- methods KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80648004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol+and+drug+abuse+prevention+in+adolescents.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-03-01&rft.volume=15&rft.issue=2&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-29 N1 - Date created - 1991-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Scanning electron microscopic analysis of mineral fiber content of lung tissue in the evaluation of diffuse pulmonary fibrosis. AN - 80624641; 2052931 AB - The mineral fiber content of lung parenchyma in 24 cases of diffuse pulmonary fibrosis of unknown cause was determined by scanning electron microscopy and compared with that of 36 autopsy cases of histologically confirmed asbestosis and 20 autopsy cases of patients with normal lungs. Fibers were isolated from the lung using a hypochlorite digestion technique and collected on the surface of a polycarbonate filter. In addition, the types of fibers present (asbestos vs. other mineral fibers) were determined by energy dispersive x-ray analysis (EDXA). When the histologic grade of fibrosis in the cases of asbestosis was compared with the uncoated fiber content by means of linear regression analysis, it was determined that the fiber content of the 24 cases of diffuse pulmonary fibrosis of unknown cause was below the 95% confidence limit for asbestosis in every instance. Furthermore, the majority of fibers analyzed by EDXA were not asbestos in the cases with diffuse pulmonary fibrosis of unknown cause, whereas more than 90% of the fibers from the asbestosis cases were commercial amphiboles (amosite or crocidolite). It was concluded that most patients with advanced pulmonary fibrosis whose tissue samples do not meet histologic criteria for asbestosis do not have asbestos-induced fibrosis, even though there may be some history of exposure to asbestos. In such cases, scanning electron microscopic analysis of mineral fiber content and EDXA of the types of fibers present often provide useful information with regard to the correct classification of these cases. JF - Scanning microscopy AU - Roggli, V L AD - Department of Pathology, Durham Veterans Administration Medical Center, North Carolina 27710. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 71 EP - 80; discussion 80-3 VL - 5 IS - 1 SN - 0891-7035, 0891-7035 KW - Minerals KW - 0 KW - Index Medicus KW - Regression Analysis KW - Aged, 80 and over KW - Humans KW - Asbestosis -- pathology KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Microscopy, Electron, Scanning KW - Pulmonary Fibrosis -- pathology KW - Lung -- ultrastructure KW - Minerals -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80624641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+microscopy&rft.atitle=Scanning+electron+microscopic+analysis+of+mineral+fiber+content+of+lung+tissue+in+the+evaluation+of+diffuse+pulmonary+fibrosis.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1991-03-01&rft.volume=5&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Scanning+microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug treatment of schizophrenia. Overview of recent research. AN - 80584725; 1674883 AB - The authors review recent research findings on the drug treatment of schizophrenia. A number of studies emphasize that neuroleptic medications are severely limited by neurological side effects that include acute extrapyramidal syndromes and tardive dyskinesia. Studies comparing neuroleptic doses in both acute and maintenance therapy have encouraged clinicians to evaluate methods for treating patients with the lowest effective dose. Other studies, but not all, indicate that plasma level measurement may be helpful in decision making about drug dosage. The management of schizophrenic patients with illnesses that are refractory to conventional neuroleptics is also discussed. Clozapine, an atypical neuroleptic, may be more effective than other available neuroleptics for severely ill, treatment refractory patients or patients who are unable to tolerate the neurological side effects of typical neuroleptics. JF - Schizophrenia research AU - Marder, S R AU - Wirshing, W C AU - Van Putten, T AD - West Los Angeles Veterans Administration Medical Center, Brentwood Division, CA 90073. PY - 1991 SP - 81 EP - 90 VL - 4 IS - 2 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Psychotropic Drugs KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Arousal -- drug effects KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Long-Term Care KW - Antipsychotic Agents -- adverse effects KW - Psychotropic Drugs -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Psychotropic Drugs -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80584725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Drug+treatment+of+schizophrenia.+Overview+of+recent+research.&rft.au=Marder%2C+S+R%3BWirshing%2C+W+C%3BVan+Putten%2C+T&rft.aulast=Marder&rft.aufirst=S&rft.date=1991-03-01&rft.volume=4&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-11 N1 - Date created - 1991-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of suture and tubulization nerve repair techniques in a primate. AN - 80536503; 1850770 AB - This study compared standard methods of nerve repair, epineurial or perineurial sutures with a technique termed fascicular tubulization using a biodegradable polyglycolic acid tube in a nonhuman primate model. Electrophysiologic analysis demonstrated that the percentage of proximal axons that conducted across the repair site did not significantly differ among the three techniques while epineurial suture repairs were associated with significantly longer conduction delays across the repair site compared with the other two techniques. Even though fascicular tubulization using the current polyglycolic acid tube resulted in regeneration equal to the currently perceived best suture repair technique, associated technical problems with the current tube design indicate that this fascicular tubulization technique cannot, at present, be considered as an alternative to present clinically used nerve suture techniques. JF - The Journal of hand surgery AU - Hentz, V R AU - Rosen, J M AU - Xiao, S J AU - McGill, K C AU - Abraham, G AD - Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, Calif. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 251 EP - 261 VL - 16 IS - 2 SN - 0363-5023, 0363-5023 KW - Polyglycolic Acid KW - 26009-03-0 KW - Index Medicus KW - Neural Conduction -- physiology KW - Animals KW - Nerve Crush KW - Macaca fascicularis KW - Nerve Regeneration -- physiology KW - Biodegradation, Environmental KW - Axons -- physiology KW - Ulnar Nerve -- physiology KW - Ulnar Nerve -- surgery KW - Median Nerve -- physiology KW - Suture Techniques KW - Median Nerve -- surgery KW - Prostheses and Implants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80536503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+hand+surgery&rft.atitle=A+comparison+of+suture+and+tubulization+nerve+repair+techniques+in+a+primate.&rft.au=Hentz%2C+V+R%3BRosen%2C+J+M%3BXiao%2C+S+J%3BMcGill%2C+K+C%3BAbraham%2C+G&rft.aulast=Hentz&rft.aufirst=V&rft.date=1991-03-01&rft.volume=16&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+hand+surgery&rft.issn=03635023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Decrease in endothelial cell-dependent protein C activation induced by thrombomodulin by treatment with cyclosporine. AN - 80482157; 1848730 AB - The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr with a wide range of CSA concentrations. After removal of CSA and incubation with thrombin and purified protein C, thrombomodulin-dependent protein C activation was measured with an S-2238-based kinetic chromogenic assay. As compared to control, a significant fall in thrombomodulin activity occurred after 24-hr incubation with 100 (70.8 +/- 15.8%, P less than 0.05), 1000 (64.9 +/- 16.6%, P less than 0.05), or 10,000 (28.9 +/- 12.3%, P less than 0.05) ng/ml of CSA. A comparable inhibition of thrombomodulin activity was also observed in cultured renal artery endothelial cells (67.5 +/- 12.6%, P less than 0.05), after 24-hr incubation with 5000 ng/ml CSA. In cells incubated with 5000 ng/ml of CSA for 4 hr, thrombomodulin activity fell by almost 15% (85.6 +/- 8.3%, P less than 0.05) and tended to plateau between 7 hr (73.8 +/- 12.7%, P less than 0.05), and 24 hr of incubation (72.7 +/- 8.9%, P less than 0.05). These results indicate that CSA produces a time- and dose-dependent reduction in thrombomodulin activity of cultured endothelial cells, downregulating the protein C anticoagulant pathway, thereby increasing the risk of thrombosis. JF - Transplantation AU - Garcia-Maldonado, M AU - Kaufman, C E AU - Comp, P C AD - Department of Medicine, University of Oklahoma, Oklahoma City Veterans Administration Medical Center, Oklahoma City 73104. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 701 EP - 705 VL - 51 IS - 3 SN - 0041-1337, 0041-1337 KW - Cyclosporins KW - 0 KW - Protein C KW - Receptors, Cell Surface KW - Receptors, Thrombin KW - Thrombin KW - EC 3.4.21.5 KW - Index Medicus KW - Thrombosis -- chemically induced KW - Thrombin -- physiology KW - Models, Cardiovascular KW - Animals KW - Cattle KW - Cells, Cultured KW - Kinetics KW - Aorta KW - Renal Artery KW - Protein C -- metabolism KW - Endothelium, Vascular -- drug effects KW - Cyclosporins -- toxicity KW - Cyclosporins -- pharmacology KW - Receptors, Cell Surface -- physiology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80482157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Decrease+in+endothelial+cell-dependent+protein+C+activation+induced+by+thrombomodulin+by+treatment+with+cyclosporine.&rft.au=Garcia-Maldonado%2C+M%3BKaufman%2C+C+E%3BComp%2C+P+C&rft.aulast=Garcia-Maldonado&rft.aufirst=M&rft.date=1991-03-01&rft.volume=51&rft.issue=3&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of alcohols and other hypnotics in mice selected for differential sensitivity to hypothermic actions of ethanol. AN - 80480341; 2005589 AB - Mice selectively bred for resistance (HOT) and sensitivity (COLD) to the hypothermic effect of an acute dose of ethanol were tested twice during the course of genetic selection for their hypothermic response to other alcohols and sedative hypnotics. The drugs administered were ethanol, propanol, n-butanol, t-butanol, pentanol, diazepam, phenobarbital, pentobarbital, methyprylon and ethchlorvynol, all of which have sedative effects on the central nervous system, and hydralazine, a peripheral vasodilator. All drugs decreased body temperature of both HOT and COLD mice. In mice selected for seven to nine generations, COLD mice were more sensitive than HOT mice to all sedative drugs. The longer-chain alcohols were more potent than ethanol in inducing hypothermia, but the magnitude of the response difference between HOT and COLD mice appeared to be smaller. The difference between HOT and COLD mice in hypothermic sensitivity to an acute dose of ethanol was greater after 11-15 generations of selection than after seven generations. Similarly, the differential effect of the other alcohols, phenobarbital, pentobarbital, and methyprylon, on HOT and COLD mice increased with more generations of selection but to a lesser extent than ethanol. These data demonstrate that selecting for sensitivity to acute ethanol hypothermia has produced mice that are also differentially sensitive to other sedative hypnotic agents. They also support the hypothesis that the drugs used in the present study share a common mechanism of action for inducing hypothermia, which may be regulated by a common set of genes.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Feller, D J AU - Crabbe, J C AD - Research Service, Veterans Administration Medical Center, Portland, Oregon. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 947 EP - 953 VL - 256 IS - 3 SN - 0022-3565, 0022-3565 KW - Alcohols KW - 0 KW - Hypnotics and Sedatives KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Body Temperature -- drug effects KW - Mice KW - Male KW - Female KW - Structure-Activity Relationship KW - Hypnotics and Sedatives -- toxicity KW - Hypothermia -- chemically induced KW - Ethanol -- toxicity KW - Alcohols -- toxicity KW - Hypothermia -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80480341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effect+of+alcohols+and+other+hypnotics+in+mice+selected+for+differential+sensitivity+to+hypothermic+actions+of+ethanol.&rft.au=Feller%2C+D+J%3BCrabbe%2C+J+C&rft.aulast=Feller&rft.aufirst=D&rft.date=1991-03-01&rft.volume=256&rft.issue=3&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice. AN - 80478777; 2005587 AB - Differences in antinociceptive (inhibition of tail-flick response) action of morphine and Tyr-D-Ala2-Gly-NMePhe4-ol5 (DAMGO) were demonstrated by intracerebroventricular (i.c.v.) administration of these agonists along with intrathecal (i.t.) administration of a variety of antagonists: yohimbine, methysergide, naloxone and nor-binaltorphimine. Intracerebroventricular morphine analgesia was antagonized by either i.t. yohimbine or methysergide, whereas i.c.v. DAMGO analgesia was only antagonized by i.t. methysergide. Thus, for i.c.v. morphine-induced analgesia, descending spinal noradrenergic and serotonergic systems were involved, whereas for DAMGO analgesia, only the serotonergic system was involved. The dose-response curve for i.c.v. morphine reached a plateau at high doses, whereas i.c.v. DAMGO analgesia peaked at 10 ng and then decreased thereafter, producing a bell-shaped dose-response curve. This decrement in analgesic response could be reversed by low doses of i.t. methysergide and i.t. pindolol. It was concluded that activation of serotonin-1 (5-HT1) receptors plays a role in the decrease in analgesia from high doses of DAMGO. Combinations of i.t. morphine with i.t. 5-HT or i.t. clonidine produced additive or greater analgesic responses. Combinations of i.t. DAMGO with i.t. 5-HT or i.t. clonidine produced less than additive interactions. Part of the latter responses appeared to be due to activation of 5-HT1 receptors; blockade of these receptors by pindolol enhanced i.t. DAMGO-induced analgesia. Morphine and DAMGO differ further because i.c.v. morphine activated a descending antianalgesic pathway mediated by spinal dynorphin A(1-17), whereas i.c.v. DAMGO at a high dose did not. Thus, morphine and DAMGO differ in their modes of antinociceptive action as measured by the tail-flick response. JF - The Journal of pharmacology and experimental therapeutics AU - Arts, K S AU - Holmes, B B AU - Fujimoto, J M AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 890 EP - 896 VL - 256 IS - 3 SN - 0022-3565, 0022-3565 KW - Enkephalins KW - 0 KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - Yohimbine KW - 2Y49VWD90Q KW - Serotonin KW - 333DO1RDJY KW - Morphine KW - 76I7G6D29C KW - Clonidine KW - MN3L5RMN02 KW - Methysergide KW - XZA9HY6Z98 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Drug Interactions KW - Yohimbine -- pharmacology KW - Dose-Response Relationship, Drug KW - Injections, Spinal KW - Methysergide -- pharmacology KW - Mice KW - Clonidine -- pharmacology KW - Male KW - Injections, Intraventricular KW - Serotonin -- pharmacology KW - Enkephalins -- pharmacology KW - Analgesia KW - Enkephalins -- administration & dosage KW - Morphine -- administration & dosage KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80478777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Differential+contribution+of+descending+serotonergic+and+noradrenergic+systems+to+central+Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5+%28DAMGO%29+and+morphine-induced+antinociception+in+mice.&rft.au=Arts%2C+K+S%3BHolmes%2C+B+B%3BFujimoto%2C+J+M&rft.aulast=Arts&rft.aufirst=K&rft.date=1991-03-01&rft.volume=256&rft.issue=3&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of blood flow and alkaline secretion in acid-induced deep duodenal villous injury in rats. AN - 80472679; 2003607 AB - The effect of 16,16-dimethylprostaglandin E2 (dmPGE2) and corticotropin-releasing factor (CRF) on duodenal blood flow, alkaline secretion, and acid-induced deep duodenal villous injury was studied. The duodena of anesthetized rats were prepared for simultaneous measurement of alkaline secretion by back titration, and blood flow by hydrogen gas clearance; or for perfusion with 0.1 N HCl and histological examination of villous injury. The results revealed that the dmPGE2-induced increase in basal alkaline secretion (due solely to an increase in the volume of secretion) appears to be a better predictor of protection against exogenous acid-induced deep duodenal villous injury than rise in duodenal blood flow, since CRF induces a similar rise in duodenal blood flow but does not enhance alkaline secretion or reduce acid-induced villous damage. The absence of a greater loss of H+ during acid perfusion of the duodenum in the dmPGE2-treated rats, however, suggests that the mechanism of the dmPGE2 protection against acid-induced deep duodenal villous injury cannot be explained entirely by its ability to increase basal duodenal alkaline secretion. JF - The American journal of physiology AU - Leung, F W AD - Research Service, Veterans Administration Medical Center, Sepulveda 91343. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - G399 EP - G404 VL - 260 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - 16,16-Dimethylprostaglandin E2 KW - M790V82VAC KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Regional Blood Flow -- drug effects KW - Male KW - Hydrochloric Acid -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - 16,16-Dimethylprostaglandin E2 -- pharmacology KW - Intestinal Mucosa -- blood supply KW - Duodenum -- blood supply KW - Corticotropin-Releasing Hormone -- pharmacology KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80472679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+blood+flow+and+alkaline+secretion+in+acid-induced+deep+duodenal+villous+injury+in+rats.&rft.au=Leung%2C+F+W&rft.aulast=Leung&rft.aufirst=F&rft.date=1991-03-01&rft.volume=260&rft.issue=3+Pt+1&rft.spage=G399&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-12 N1 - Date created - 1991-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dual pathways for agonist-stimulated arachidonic acid release in pancreatic acini: roles in secretion. AN - 80472636; 1706148 AB - The present experiments were performed to determine pathways responsible for arachidonic acid release stimulated by cholecystokinin (CCK) and phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA), and the roles of pathways in the secretory response in dispersed acini from guinea pig pancreas. Both CCK-octapeptide (CCK-OP) and PMA increased intracellular arachidonic acid. To determine the source of released arachidonic acid, we measured the effects of PMA and CCK-OP on cellular 1,2-diacylglycerol and lysophosphatidylcholine (LPC) and of diglyceride lipase inhibitor RHC 80267 on [3H]arachidonic acid release. Both PMA and CCK-OP increased 1,2-diacylglycerol and LPC. RHC 80267 had no effect on LPC but inhibited the increase in [3H]arachidonic acid release with a concentration of CCK-OP that was maximal for enzyme secretion. The increase in [3H]arachidonic acid release with PMA or a supramaximal concentration of CCK-OP was not inhibited by RHC 80267. In parallel fashion, RHC 80267 inhibited amylase release caused by maximally effective concentrations of CCK-OP but not that caused by PMA or by supramaximally effective concentrations of CCK-OP. Arachidonic acid stimulated amylase release. Exogenous addition of phospholipase A2 caused increases in [3H]arachidonic acid release, LPC formation, and amylase release. The results indicate that there are at least two pathways responsible for the increase in free cellular arachidonic acid stimulated by pancreatic agonists. One is sequential action of phospholipase C and diglyceride lipase on phosphatidylinositol. The other is a phospholipase A action on phosphatidylcholine. The results also suggest a stimulatory role for both pathways in the secretory response. JF - The American journal of physiology AU - Pandol, S J AU - Hsu, Y L AU - Kondratenko, N F AU - Schoeffield-Payne, M S AU - Steinbach, J H AD - Department of Medicine, Veterans Administration Medical Center, San Diego, California. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - G423 EP - G433 VL - 260 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Arachidonic Acids KW - 0 KW - Cyclohexanones KW - Diglycerides KW - Fatty Acids KW - Lysophosphatidylcholines KW - Phosphatidylcholines KW - 1,6-bis(cyclohexyloximinocarbonyl)hexane KW - 83654-05-1 KW - Phospholipases A KW - EC 3.1.1.32 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Amylases KW - EC 3.2.1.- KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Lysophosphatidylcholines -- isolation & purification KW - Guinea Pigs KW - Cyclohexanones -- pharmacology KW - Phosphatidylcholines -- metabolism KW - Phosphatidylcholines -- isolation & purification KW - Lipoprotein Lipase -- antagonists & inhibitors KW - Phospholipases A -- pharmacology KW - Kinetics KW - In Vitro Techniques KW - Lysophosphatidylcholines -- pharmacology KW - Lysophosphatidylcholines -- metabolism KW - Fatty Acids -- analysis KW - Diglycerides -- metabolism KW - Pancreas -- cytology KW - Pancreas -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Arachidonic Acids -- metabolism KW - Amylases -- secretion KW - Pancreas -- drug effects KW - Sincalide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80472636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Dual+pathways+for+agonist-stimulated+arachidonic+acid+release+in+pancreatic+acini%3A+roles+in+secretion.&rft.au=Pandol%2C+S+J%3BHsu%2C+Y+L%3BKondratenko%2C+N+F%3BSchoeffield-Payne%2C+M+S%3BSteinbach%2C+J+H&rft.aulast=Pandol&rft.aufirst=S&rft.date=1991-03-01&rft.volume=260&rft.issue=3+Pt+1&rft.spage=G423&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-12 N1 - Date created - 1991-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic effect of human lysozyme plus ampicillin or beta-lysin on the killing of Listeria monocytogenes. AN - 80451742; 1899873 AB - Although ampicillin is often only bacteriostatic for Listeria monocytogenes in vitro, serum from ampicillin-treated patients was bactericidal. The bactericidal effect of serum was partly removed by bentonite, Seitz-filtration, and addition of FeCl3, suggesting it is mediated by lysozyme and beta-lysin. Partly purified human beta-lysin plus purified human lysozyme or either protein plus ampicillin were bactericidal for L. monocytogenes. Hen egg white lysozyme was not active. Lysozyme and beta-lysin were not synergistic with tetracycline, trimethoprim/sulfamethoxazole, or chloramphenicol. Thus, lysozyme and beta-lysin may play a role in the natural resistance to L. monocytogenes, and these serum proteins could contribute to the effectiveness of ampicillin in vivo. JF - The Journal of infectious diseases AU - Asensi, V AU - Fierer, J AD - Department of Medicine, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 574 EP - 578 VL - 163 IS - 3 SN - 0022-1899, 0022-1899 KW - Antimicrobial Cationic Peptides KW - 0 KW - Blood Proteins KW - Proteins KW - beta lysin, human KW - Ampicillin KW - 7C782967RD KW - Muramidase KW - EC 3.2.1.17 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Proteins -- pharmacology KW - Listeria monocytogenes -- drug effects KW - Proteins -- isolation & purification KW - Muramidase -- pharmacology KW - Ampicillin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80451742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Synergistic+effect+of+human+lysozyme+plus+ampicillin+or+beta-lysin+on+the+killing+of+Listeria+monocytogenes.&rft.au=Asensi%2C+V%3BFierer%2C+J&rft.aulast=Asensi&rft.aufirst=V&rft.date=1991-03-01&rft.volume=163&rft.issue=3&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-25 N1 - Date created - 1991-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholism and associated malnutrition in the elderly. AN - 72693623; 1802200 AB - Although most free-living people over age 55 yr use alcohol occasionally, both the fraction of people drinking and the magnitude of individual alcohol consumption decrease with every decade of age. Overall, approximately 5% of drinkers over age 55 yr use alcohol at excessive levels, i.e., sufficient to interfere with health or social functioning. As age increases, the fraction of drinkers with alcohol-caused central nervous system disease and cirrhosis increases, indicating increased sensitivity to alcohol injury. Beyond age 70 yr, new-onset alcoholism is more common than long-standing alcoholism. Malnutrition in the elderly alcoholic person is rare; it usually is caused by multiple factors, including alcohol displacing nutrient-rich diet factors, disease, limited availability of food, or altered metabolism increasing nutrient requirement. The recognition of alcohol and malnutrition problems in the elderly is more difficult than in younger people. JF - Nutrition (Burbank, Los Angeles County, Calif.) AU - Klein, S AU - Iber, F L AD - Department of Nutrition, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois 60141. PY - 1991 SP - 75 EP - 79 VL - 7 IS - 2 SN - 0899-9007, 0899-9007 KW - Index Medicus KW - Nutritional Status KW - Humans KW - Aged KW - Middle Aged KW - Aging -- physiology KW - Alcoholism -- epidemiology KW - Nutrition Disorders -- etiology KW - Alcoholism -- complications KW - Nutrition Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72693623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.atitle=Alcoholism+and+associated+malnutrition+in+the+elderly.&rft.au=Klein%2C+S%3BIber%2C+F+L&rft.aulast=Klein&rft.aufirst=S&rft.date=1991-03-01&rft.volume=7&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.issn=08999007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-30 N1 - Date created - 1992-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The catalytic effect of bovine serum albumin on the ortho rearrangement of the potential ultimate carcinogen, N-(sulfooxy)-2-(acetylamino)fluorene, generated enzymatically from N-hydroxy-2-(acetylamino)fluorene and evidence for substrate specificity of the enzymatic sulfonation of arylhydroxamic acids. AN - 72632428; 1782347 AB - This investigation examines the catalytic effect of bovine serum albumin on the ortho rearrangement of the possible ultimate carcinogen, N-(sulfooxy)-2-(acetylamino)fluorene, generated from N-hydroxy-2-(acetylamino)fluorene by the sulfotransferase(s) in the cytosol of rat liver. With various preparations of cytosol, 55-75% of the substrate, N-hydroxy-2-(acetylamino)-fluorene, was found to rearrange to the nonmutagenic and noncarcinogenic o-(sulfooxy) esters, 1- and 3-(sulfooxy)-2-(acetylamino)fluorene, in the presence of bovine serum albumin, while less than 1% of the substrate rearranged in its absence. In presence of bovine serum albumin the cytosolic reduction of N-(sulfooxy)-2-(acetylamino)fluorene to 2-(acetylamino)fluorene decreased by 60-90% and its solvolytic degradation to 4-hydroxy-2-(acetylamino)fluorene by 80-90%. The covalent interaction of enzymatically generated N-(sulfooxy)-2-(acetylamino)fluorene with the nucleophilic acceptors, N-acetyl-L-methionine and guanosine, was lowered by greater than 90% by addition of bovine serum albumin. These measurements indicated that the albumin-catalyzed ortho rearrangement controls the rates of concurrent metabolic and degradative reactions of N-(sulfooxy)-2-(acetylamino)fluorene. The results are in agreement with previous findings of a catalytic effect of serum albumin on the ortho rearrangement of synthetic N-(sulfooxy)-2-(acetylamino)fluorene. In contrast to its catalytic effect on the formation of o-(sulfooxy) esters from N-(sulfooxy)-2-(acetylamino)fluorene, bovine serum albumin had no effect on the formation of o-(acetylamino)fluorenols. To assess the substrate specificity of bovine serum albumin, its effect on the rearrangement of N-hydroxy-2-(benzoylamino)fluorene, a carcinogenic analogue of N-hydroxy-2-(acetylamino)fluorene, was analyzed under conditions of cytosolic sulfonation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Kolanczyk, R C AU - Rutks, I R AU - Gutmann, H R AD - Research Service, Veterans' Administration Medical Center, Minneapolis, Minnesota 55417. PY - 1991 SP - 187 EP - 194 VL - 4 IS - 2 SN - 0893-228X, 0893-228X KW - Carcinogens KW - 0 KW - Fluorenes KW - Hydroxamic Acids KW - Serum Albumin, Bovine KW - N-1-sulfooxy-2-benzoylaminofluorene KW - 131657-39-1 KW - 2-acetylaminofluorene-N-sulfate KW - 16808-85-8 KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Fluorenes -- isolation & purification KW - Fluorenes -- chemical synthesis KW - Animals KW - Liver -- enzymology KW - Liver -- metabolism KW - Substrate Specificity KW - Hydroxamic Acids -- metabolism KW - Male KW - Hydroxyacetylaminofluorene -- metabolism KW - 2-Acetylaminofluorene -- chemical synthesis KW - Carcinogens -- metabolism KW - 2-Acetylaminofluorene -- metabolism KW - Serum Albumin, Bovine -- pharmacology KW - 2-Acetylaminofluorene -- analogs & derivatives KW - Carcinogens -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72632428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=The+catalytic+effect+of+bovine+serum+albumin+on+the+ortho+rearrangement+of+the+potential+ultimate+carcinogen%2C+N-%28sulfooxy%29-2-%28acetylamino%29fluorene%2C+generated+enzymatically+from+N-hydroxy-2-%28acetylamino%29fluorene+and+evidence+for+substrate+specificity+of+the+enzymatic+sulfonation+of+arylhydroxamic+acids.&rft.au=Kolanczyk%2