TY - JOUR T1 - Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function. AN - 85230984; pmid-8402185 AB - We have demonstrated that aged rats show impairments in learning patterned motor movements. Similar behavioral impairment is observed in rats with noradrenergic lesions. Norepinephrine is known to act as a neuromodulator in the cerebellar cortex because it can augment the action of GABA and other neurotransmitters. This effect of NE to augment the signal to noise ratio of GABAergic inputs to cerebellar Purkinje neurons is a possible substrate for NE's effect on motor learning. Aged rats demonstrate deficits in the modulatory actions of NE to augment GABAergic inhibitions when both substances are locally applied onto cerebellar Purkinje neurons. In this report, we examined how motor learning and cerebellar noradrenergic function varied in individual young and 20-month-old Fischer 344 rats. There was a significant correlation between the loss of the neuromodulatory actions of norepinephrine (NE) in the cerebellar cortex and the rate of learning a novel motor task in individual rats. This report thus demonstrates for the first time a correlation between age-related impairments in motor plasticity and specific neurophysiological deficits in cerebellar Purkinje neurons in individual animals. JF - Brain Research AU - Bickford, P AD - Veterans Administration Medical Center, Denver, CO. PY - 1993 SP - 133 EP - 138 VL - 620 IS - 1 SN - 0006-8993, 0006-8993 KW - Learning KW - Support, U.S. Gov't, P.H.S. KW - Aging KW - Animal KW - Cerebellum KW - Electrophysiology KW - Learning Disorders KW - Isoproterenol KW - Rats KW - Rats, Inbred F344 KW - gamma-Aminobutyric Acid KW - Norepinephrine KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Drug Synergism KW - Male KW - Motor Activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Motor+learning+deficits+in+aged+rats+are+correlated+with+loss+of+cerebellar+noradrenergic+function.&rft.au=Bickford%2C+P&rft.aulast=Bickford&rft.aufirst=P&rft.date=1993-08-01&rft.volume=620&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Impact of chronic alcoholism on the aging rat: changes in nutrition, liver composition, and mortality. AN - 75963139; 8214425 AB - The adverse effects of chronic alcohol consumption (mean 6.68 g/kg/d) were assessed in 150 male Sprague-Dawley rats over their life span (25 months). Evaluations were performed at 2, 3, 8, 13, 19, and 25 months of age for changes in nutrition status, biochemical tests for liver injury, compositional changes in liver, and hepatic regenerative capacity. In spite of nearly identical caloric intake, alcohol treatment was associated with nutritional levels 10-30% lower than controls. Maximal changes were observed at the two extremes of ages (2-3 months and 19-25 months). Hence, a nutritional contribution to other adverse changes could not be excluded. Fatty compositional increases (triglycerides) occurred early (5-fold increases after 1 month of treatment) then declined to levels only slightly above controls. Biochemical tests on sera for liver injury (AST and total bilirubin) were consistently higher with alcohol treatment. Regenerative capacity measured by [3H]thymidine uptake after partial hepatectomy was initially elevated in the alcoholic then rapidly declined beyond 7 months of age. In control animals, an age-related decline was also observed but occurred later beyond 12 months of age. Consistent with these adverse effects, ethanol diet survival was poorer than the pair-fed control groups by 15% (median survival for alcoholics, 17 months vs. 20 months in controls. JF - Alcoholism, clinical and experimental research AU - Mendenhall, C L AU - Rouster, S D AU - Roselle, G A AU - Grossman, C J AU - Ghosn, S AU - Gartside, P AD - Department of Veterans Affairs, Veterans Administration Medical Center, Cincinnati, OH 45220. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 847 EP - 853 VL - 17 IS - 4 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Liver Regeneration -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Age Factors KW - Body Weight -- drug effects KW - Fatty Liver, Alcoholic -- pathology KW - Liver Function Tests KW - Male KW - Liver Diseases, Alcoholic -- pathology KW - Alcoholism -- pathology KW - Energy Metabolism -- drug effects KW - Longevity -- drug effects KW - Ethanol -- toxicity KW - Body Composition -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75963139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Impact+of+chronic+alcoholism+on+the+aging+rat%3A+changes+in+nutrition%2C+liver+composition%2C+and+mortality.&rft.au=Mendenhall%2C+C+L%3BRouster%2C+S+D%3BRoselle%2C+G+A%3BGrossman%2C+C+J%3BGhosn%2C+S%3BGartside%2C+P&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1993-08-01&rft.volume=17&rft.issue=4&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-11-23 N1 - Date created - 1993-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of mu-conotoxin GIIIA for the study of synaptic transmission at the frog neuromuscular junction. AN - 76053785; 8233060 AB - We have looked at the effect of synthetic mu-conotoxin GIIIA, a selective blocker of muscle Na channels, on various parameters of synaptic transmission at the frog sartorius nerve-muscle preparation. We found that 5 microM mu-conotoxin consistently blocked muscle action potentials, but had no effect on nerve action potentials. The toxin also had no effect on the amplitude or frequency of miniature endplate potentials (MEPPs), on the amplitude or time course of endplate potentials (EPPs), or on stimulation-induced changes in EPP amplitude. The lack of an effect of synthetic mu-conotoxin GIIIA on transmitter release makes this toxin an invaluable tool in the study of neuromuscular transmission under conditions of normal levels of release. JF - Neuroscience letters AU - Sosa, M A AU - Zengel, J E AD - Veterans Administration Medical Center, Gainesville, FL. Y1 - 1993/07/23/ PY - 1993 DA - 1993 Jul 23 SP - 235 EP - 238 VL - 157 IS - 2 SN - 0304-3940, 0304-3940 KW - Conotoxins KW - 0 KW - Mollusk Venoms KW - Peptides, Cyclic KW - Sodium Channels KW - conotoxin GIII KW - 101484-15-5 KW - Index Medicus KW - Rana pipiens KW - Animals KW - Peripheral Nerves -- drug effects KW - Action Potentials -- drug effects KW - Peripheral Nerves -- physiology KW - Muscles -- physiology KW - Muscles -- drug effects KW - Neuromuscular Junction -- drug effects KW - Mollusk Venoms -- pharmacology KW - Synaptic Transmission -- drug effects KW - Peptides, Cyclic -- pharmacology KW - Sodium Channels -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76053785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Use+of+mu-conotoxin+GIIIA+for+the+study+of+synaptic+transmission+at+the+frog+neuromuscular+junction.&rft.au=Sosa%2C+M+A%3BZengel%2C+J+E&rft.aulast=Sosa&rft.aufirst=M&rft.date=1993-07-23&rft.volume=157&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-14 N1 - Date created - 1993-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Four ricin chain A-based immunotoxins directed against the common chronic lymphocytic leukemia antigen: in vitro characterization. AN - 75846852; 7687163 AB - The common B-chronic lymphocytic leukemia (B-CLL) antigen (cCLLa) appears to be ideal for targeted immunotherapy in that it is the most prevalent and disease-restricted marker in B-CLL. To assess this potential, we developed four immunotoxins (ITs) of anti-cCLLa monoclonal antibody CLL2m (an IgG2a kappa), using ricin chain A (RTA) or its deglycosylated derivative (dgA), each conjugated to either the whole IgG molecule or its Fab' fragment. Each IT was tested in vitro for specificity and cytotoxic activity (assessed by protein synthesis inhibition [PSI] and by cell kill [CK] in the clonogenic assay) against B-CLL cells. RTA-based anti-CD5 ITs and enriched normal B and T lymphocytes were used as controls. Each IT exhibited antigen-specific, dose-dependent activity. Thus, whereas B-CLL cells exhibited dose-dependent PSI and CK (whether the B-CLL clone was CD5+ or CD5-), normal B (cCLLa-/CD5-) and T lymphocytes (cCLLa-/CD5+) remained unaffected. IT potency was independent of toxin glycosylation, but was slightly influenced by antibody valence; divalent ITs were twice as potent as monovalent ITs (IC50, 2.3 v 7.1 x 10(-11) mol/L; CK, 2.6- v 2.0-log reached with 524 v 1,072 IT molecules bound/cell, respectively). In the presence of ammonium chloride or Verapamil, IT-induced CK was enhanced 10- to 80-fold. These data suggest that the cCLLa is a promising target for IT-based immunotherapy of B-CLL in vivo and ex vivo. JF - Blood AU - Faguet, G B AU - Agee, J F AD - Cancer Immunology Research Laboratory, Veterans Administration Medical Center, Augusta, GA 30910. Y1 - 1993/07/15/ PY - 1993 DA - 1993 Jul 15 SP - 536 EP - 543 VL - 82 IS - 2 SN - 0006-4971, 0006-4971 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, CD5 KW - Antigens, Neoplasm KW - Antigens, Surface KW - Biomarkers, Tumor KW - Immunoglobulin Fab Fragments KW - Immunoglobulin G KW - Immunotoxins KW - Ricin KW - 9009-86-3 KW - Abridged Index Medicus KW - Index Medicus KW - Tumor Cells, Cultured KW - Kinetics KW - Immunotherapy KW - Humans KW - Cell Death KW - Glycosylation KW - Antigens, CD -- immunology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Ricin -- administration & dosage KW - Biomarkers, Tumor -- immunology KW - Ricin -- therapeutic use KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Antigens, Neoplasm -- immunology KW - Ricin -- pharmacology KW - Antigens, Surface -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75846852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Four+ricin+chain+A-based+immunotoxins+directed+against+the+common+chronic+lymphocytic+leukemia+antigen%3A+in+vitro+characterization.&rft.au=Faguet%2C+G+B%3BAgee%2C+J+F&rft.aulast=Faguet&rft.aufirst=G&rft.date=1993-07-15&rft.volume=82&rft.issue=2&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-17 N1 - Date created - 1993-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C infection by polymerase chain reaction in alcoholics: false-positive ELISA results and the influence of infection on a clinical prognostic score. AN - 85226755; pmid-8391209 AB - Antibody to hepatitis C as measured by the ELISA method is common in alcoholics. The presence of antibody to C 100-3 has been associated with more advanced disease. However, few studies have investigated the clinical significance of hepatitis C infection as defined by the presence of circulating viral RNA in alcoholics. We have prospectively examined 48 consecutive alcoholic patients for the presence of antibody to hepatitis C by an ELISA for antibody to the C100-3 antigen and by the reverse transcriptase polymerase chain reaction (PCR) using nested primers for the 5' nontranslated region of the viral RNA. Patients with liver disease were scored for disease severity by the combined clinical and laboratory index (CCLI). Overall, 12 of 48 patients (25%) were ELISA positive and eight of 48 (16%) were PCR positive. Among the 34 patients with liver disease, 10 (29%) were ELISA positive and six (18%) were PCR positive. All PCR-positive patients were also ELISA positive. There was no significant difference in the disease severity score (CCLI) or the duration of clinical disease in PCR-positive versus PCR-negative patients with liver disease. However, PCR-positive patients were significantly younger (43 +/- 6 vs. 55 +/- 10 yr, p = 0.001), indicating an earlier onset of severe disease in PCR-positive patients. There were no false-negative ELISA tests in either those with or those without liver disease. Among the 34 patients with liver disease, four of 10 patients with positive antibody were negative by PCR. Neither individual immunoglobulin levels (IgG, IgM, IgA) nor total globulins were significantly different between the ELISA-positive/PCR-negative patients and ELISA-positive/PCR-positive patients. When the entire group of 34 patients with liver disease was considered, we could not detect a significant correlation between ELISA absorbance and total globulins, and only a weak correlation between absorbance and immunoglobulin G (p = 0.49). These data show that the majority of alcoholic patients with liver disease and positive antibody to hepatitis C also have demonstrable viremia by PCR, and may require further evaluation and treatment. Elevated immunoglobulins in these patients do not correlate strongly with ELISA absorbance for anti-HCV. The presence of clinically advanced disease at a significantly younger age in the PCR-positive group is consistent with the concept of synergy between active viral infection and alcohol abuse in the development of liver disease in alcoholic patients. JF - The American Journal of Gastroenterology AU - Caldwell, S H AU - Li X AU - Rourk, R M AU - Millar, A AU - Sosnowski, K M AU - Sue, M AU - Barritt, A S AU - McCallum, R W AU - Schiff, E R AD - Salem Veterans Administration Medical Center, Virginia. PY - 1993 SP - 1016 EP - 1021 VL - 88 IS - 7 SN - 0002-9270, 0002-9270 KW - Liver Diseases, Alcoholic KW - Hepacivirus KW - Prospective Studies KW - Human KW - Alcoholism KW - Prognosis KW - Middle Age KW - Hepatitis C KW - RNA, Viral KW - Immunoglobulins KW - False Positive Reactions KW - Polymerase Chain Reaction KW - Enzyme-Linked Immunosorbent Assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Hepatitis+C+infection+by+polymerase+chain+reaction+in+alcoholics%3A+false-positive+ELISA+results+and+the+influence+of+infection+on+a+clinical+prognostic+score.&rft.au=Caldwell%2C+S+H%3BLi+X%3BRourk%2C+R+M%3BMillar%2C+A%3BSosnowski%2C+K+M%3BSue%2C+M%3BBarritt%2C+A+S%3BMcCallum%2C+R+W%3BSchiff%2C+E+R&rft.aulast=Caldwell&rft.aufirst=S&rft.date=1993-07-01&rft.volume=88&rft.issue=7&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Adenocarcinoma of a Brooke ileostomy for adenomatous polyposis coli. AN - 85224740; pmid-8391212 AB - A case of primary adenocarcinoma of a Brooke ileostomy after proctocolectomy for adenomatous polyposis coli is reported, and three additional cases collected from the literature are described. This rare tumor is seen at an average interval of 22 yr after colectomy with ileostomy. In all four cases, the mucosa adjacent to tumor had straight tubular glands lined by goblet cells and an absence of villi characteristic of colonic mucosa. Mucosal biopsies in all four stained positive for colonic sulfomucin. The clinical and morphologic features indicate a progression from ileal mucosa to colonic mucosa, colonic dysplasia, and finally, adenocarcinoma. Thirteen patients with adenocarcinoma of the ileostomy after proctocolectomy for ulcerative colitis have also been reported. Annual ileostomy examination, biopsy of suspicious lesions, and wide excision of carcinoma with stomal revision are recommended. JF - The American Journal of Gastroenterology AU - Johnson, J A AU - Talton, D S AU - Poole, G V AD - Department of Surgery, Veterans Administration Medical Center, Jackson, Mississippi. PY - 1993 SP - 1122 EP - 1124 VL - 88 IS - 7 SN - 0002-9270, 0002-9270 KW - Adenomatous Polyposis Coli KW - Human KW - Adult KW - Aged KW - Ileostomy KW - Case Report KW - Adenocarcinoma KW - Female KW - Male KW - Neoplasms, Second Primary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Adenocarcinoma+of+a+Brooke+ileostomy+for+adenomatous+polyposis+coli.&rft.au=Johnson%2C+J+A%3BTalton%2C+D+S%3BPoole%2C+G+V&rft.aulast=Johnson&rft.aufirst=J&rft.date=1993-07-01&rft.volume=88&rft.issue=7&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prevalence of hyperthyroidism in veterans hospitalized for severe cocaine dependence. AN - 75858136; 8328487 JF - The American journal of medicine AU - Burke, W M AU - Dhopesh, V P AD - Philadelphia Veterans Administration Medical Center, Pennsylvania. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 113 EP - 114 VL - 95 IS - 1 SN - 0002-9343, 0002-9343 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Veterans KW - Hospitalization KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Prevalence KW - Hyperthyroidism -- epidemiology KW - Substance-Related Disorders -- complications KW - Cocaine -- adverse effects KW - Hyperthyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75858136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Prevalence+of+hyperthyroidism+in+veterans+hospitalized+for+severe+cocaine+dependence.&rft.au=Burke%2C+W+M%3BDhopesh%2C+V+P&rft.aulast=Burke&rft.aufirst=W&rft.date=1993-07-01&rft.volume=95&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenylbutazone peroxidatic metabolism and conjugation. AN - 75836835; 8331577 AB - Phenylbutazone, a nonsteroidal anti-inflammatory drug, elicits therapeutic as well as toxic effects by unknown pathways. Phenylbutazone was shown to form a conjugate with the heterocyclic amine bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT). To understand further the reactivity of these compounds, this study was conducted to identify the conjugate formed and determine the mechanism of conjugate formation. Both prostaglandin H synthase and horseradish peroxidase catalyzed conjugate formation. This conjugate was identified by 1H-NMR to be 4-[2-amino-4-(5-nitro-2-furyl)-5-thiazolyl]-4-butyl-1,2-diphenyl-3,5- pyrazolidinedione. Phenylbutazone-mediated oxygen uptake was inhibited by ANFT (0.1 mM) and the spin traps 5,5-dimethyl-1-pyrroline-N-oxide (200 mM) and tert-nitrosobutane (4 mM). By contrast, phenol (0.005 to 0.25 mM) and aminopyrine (0.4 mM) stimulated oxygen uptake. None of these agents mediated oxygen uptake in the absence of phenylbutazone. Conjugate formation was significantly increased by phenol (0.005-0.25 mM) and aminopyrine (0.4 mM), as well as in the absence of oxygen. Conjugate formation was inhibited by 5,5-dimethyl-1-pyrroline-N-oxide (200 mM), tert-nitrosobutane (4 mM), ascorbic acid (2 mM), and 95% oxygen. Horseradish peroxidase initiated conjugate formation at much lower concentrations than it metabolized ANFT. The stoichiometric relationship between phenylbutazone and ANFT, with respect to conjugate formation, was complex. With the concentration of ANFT fixed at 0.05 mM, phenylbutazone exhibited saturation kinetics with a Km of 0.2 mM. In contrast, saturation kinetics were not observed with ANFT.Km values for ANFT varied with the concentration of phenylbutazone used.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Lakshmi, V M AU - Zenser, T V AU - Mattammal, M B AU - Davis, B B AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 81 EP - 88 VL - 266 IS - 1 SN - 0022-3565, 0022-3565 KW - Carcinogens KW - 0 KW - Peroxides KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - Horseradish Peroxidase KW - EC 1.11.1.- KW - Phenylbutazone KW - GN5P7K3T8S KW - Index Medicus KW - Peroxides -- metabolism KW - Biotransformation KW - Kinetics KW - Protein Binding KW - Chromatography, High Pressure Liquid KW - Horseradish Peroxidase -- metabolism KW - Phenylbutazone -- metabolism KW - FANFT -- pharmacokinetics KW - Carcinogens -- metabolism KW - FANFT -- analogs & derivatives KW - Carcinogens -- pharmacokinetics KW - FANFT -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75836835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Phenylbutazone+peroxidatic+metabolism+and+conjugation.&rft.au=Lakshmi%2C+V+M%3BZenser%2C+T+V%3BMattammal%2C+M+B%3BDavis%2C+B+B&rft.aulast=Lakshmi&rft.aufirst=V&rft.date=1993-07-01&rft.volume=266&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-19 N1 - Date created - 1993-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regional differences in mucosal hemodynamics in experimental colonic injury in rats. AN - 75831203; 8325183 AB - In rat colon damaged by 10% acetic acid and by dinitrochlorobenzene, we test the following hypotheses: (1) mucosal hemodynamic changes are significantly different at the ulcer base, the ulcer margin, and the inflamed non-ulcer-bearing mucosa; and (2) these mucosal hemodynamic changes also vary with time after induction of the colonic injury. Mucosal hemodynamic changes were documented by reflectance spectrophotometry, and variations in gross mucosal morphology were confirmed by hematoxylin and eosin histologic sections. Results revealed that in the acute stage, the ulcer base, which was covered by necrotic debris, showed ischemia without congestion. The ulcer margin at the edge of the ulcer base showed ischemia with congestion. The nonulcerated mucosa, which appeared erythematous, showed increased perfusion. In the convalescent stage, all the altered perfusion patterns returned to normal. These observations offer plausible explanations for the variability in colonic perfusion observed in experimentally damaged colons. JF - Digestive diseases and sciences AU - Leung, F W AU - Su, K C AU - Yonei, Y AU - Passaro, E AU - Guth, P H AD - Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1220 EP - 1223 VL - 38 IS - 7 SN - 0163-2116, 0163-2116 KW - Acetates KW - 0 KW - Dinitrochlorobenzene KW - GE3IBT7BMN KW - Acetic Acid KW - Q40Q9N063P KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Analysis of Variance KW - Ischemia -- epidemiology KW - Ulcer -- chemically induced KW - Ischemia -- physiopathology KW - Hemodynamics KW - Rats KW - Rats, Sprague-Dawley KW - Ulcer -- physiopathology KW - Ulcer -- epidemiology KW - Ischemia -- chemically induced KW - Time Factors KW - Male KW - Intestinal Mucosa -- physiopathology KW - Colonic Diseases -- chemically induced KW - Colonic Diseases -- epidemiology KW - Colonic Diseases -- physiopathology KW - Intestinal Mucosa -- blood supply KW - Colon -- physiopathology KW - Colon -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75831203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Regional+differences+in+mucosal+hemodynamics+in+experimental+colonic+injury+in+rats.&rft.au=Leung%2C+F+W%3BSu%2C+K+C%3BYonei%2C+Y%3BPassaro%2C+E%3BGuth%2C+P+H&rft.aulast=Leung&rft.aufirst=F&rft.date=1993-07-01&rft.volume=38&rft.issue=7&rft.spage=1220&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isoproterenol prevents ethanol-induced microvascular stasis and deep histologic injury in rat gastric mucosa. AN - 75828608; 8391972 AB - The effect of topical isoproterenol (5.8 x 10(-5) M) on the microvascular stasis and histologic injury produced in the rat gastric mucosa by absolute ethanol was investigated using in vivo microscopic and histologic techniques. Our findings show that in control animals, absolute ethanol applied to the gastric mucosa caused a rapid decrease in microvascular blood flow, leading to complete stasis by 3 min. In contrast, prior treatment of the gastric mucosa with topical isoproterenol increased microvascular blood flow initially and then maintained microvascular flow in the majority of microvessels studied after the application of absolute ethanol. Treatment with topical isoproterenol also reduced the histologic injury score and percent mucosal necrosis caused by absolute ethanol. Pretreatment of animals with a beta-adrenergic antagonist propranolol (2 mg/kg subcutaneously), completely blocked these protective effects. We observed no systemic effects attributable to the topical use of isoproterenol. These results indicate that prior treatment of the gastric mucosa with topical isoproterenol maintains microvascular blood flow and reduces the deep histologic injury in the stomach caused by 100% ethanol. JF - Digestive diseases and sciences AU - Howard, T J AU - Passaro, E AU - Guth, P H AD - Medical Service, Veterans Administration Medical Center, West Los Angeles, California 90073. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1201 EP - 1209 VL - 38 IS - 7 SN - 0163-2116, 0163-2116 KW - Receptors, Adrenergic, beta KW - 0 KW - Ethanol KW - 3K9958V90M KW - Propranolol KW - 9Y8NXQ24VQ KW - Isoproterenol KW - L628TT009W KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Microcirculation -- drug effects KW - Propranolol -- pharmacology KW - Blood Flow Velocity -- drug effects KW - Receptors, Adrenergic, beta -- drug effects KW - Time Factors KW - Male KW - Gastric Mucosa -- blood supply KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- pathology KW - Isoproterenol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75828608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Isoproterenol+prevents+ethanol-induced+microvascular+stasis+and+deep+histologic+injury+in+rat+gastric+mucosa.&rft.au=Howard%2C+T+J%3BPassaro%2C+E%3BGuth%2C+P+H&rft.aulast=Howard&rft.aufirst=T&rft.date=1993-07-01&rft.volume=38&rft.issue=7&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The influence of food on the absorption and metabolism of drugs. AN - 75820827; 8321071 AB - Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results from a reduction in the drug's bioavailability; however, an alteration in drug clearance can occur due to the effect of certain foods on drug metabolism. The proportion of adverse drug reactions due to food-drug interactions is not known and unfortunately only when a serious adverse drug reaction follows a food-drug interaction does the matter usually receive any significant attention. In order to improve therapeutic efficacy and to help prevent adverse drug reactions, it is necessary that clinicians be knowledgeable of the important food-drug incompatibilities and risk factors related to the increased likelihood of developing an adverse drug reaction due to food-drug interactions. JF - The Medical clinics of North America AU - Williams, L AU - Davis, J A AU - Lowenthal, D T AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Gainesville, Florida. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 815 EP - 829 VL - 77 IS - 4 SN - 0025-7125, 0025-7125 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Biological Availability KW - Food -- adverse effects KW - Intestinal Absorption KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75820827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Medical+clinics+of+North+America&rft.atitle=The+influence+of+food+on+the+absorption+and+metabolism+of+drugs.&rft.au=Williams%2C+L%3BDavis%2C+J+A%3BLowenthal%2C+D+T&rft.aulast=Williams&rft.aufirst=L&rft.date=1993-07-01&rft.volume=77&rft.issue=4&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=The+Medical+clinics+of+North+America&rft.issn=00257125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-05 N1 - Date created - 1993-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ergonovine testing and forearm plethysmography in cocaine-related myocardial ischemia. AN - 75803210; 8517415 JF - The American journal of cardiology AU - Halle, A A AU - Sullivan, J M AU - Ramanathan, K B AD - Division of Cardiovascular Disease, Veterans Administration Medical Center, Memphis, Tennessee. Y1 - 1993/07/01/ PY - 1993 DA - 1993 Jul 01 SP - 104 EP - 106 VL - 72 IS - 1 SN - 0002-9149, 0002-9149 KW - Cocaine KW - I5Y540LHVR KW - Ergonovine KW - WH41D8433D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Angina Pectoris -- chemically induced KW - Coronary Vasospasm -- chemically induced KW - Adult KW - Angina Pectoris -- complications KW - Plethysmography KW - Male KW - Coronary Vasospasm -- complications KW - Myocardial Ischemia -- etiology KW - Myocardial Ischemia -- diagnosis KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75803210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Ergonovine+testing+and+forearm+plethysmography+in+cocaine-related+myocardial+ischemia.&rft.au=Halle%2C+A+A%3BSullivan%2C+J+M%3BRamanathan%2C+K+B&rft.aulast=Halle&rft.aufirst=A&rft.date=1993-07-01&rft.volume=72&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-19 N1 - Date created - 1993-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A clinical and immunologic study of workers with trimellitic-anhydride-induced immunologic lung disease after transfer to low exposure jobs. AN - 75800452; 8317814 AB - The objective of the study was to determine the clinical and immunologic status of trimellitic anhydride (TMA) workers who have had immunologic lung diseases and who have been moved to lower exposure jobs. Twenty-nine consecutive workers with TMA-induced immunologic lung diseases who had been moved to low exposure jobs for more than 1 yr were studied retrospectively. Pulmonary symptoms were obtained by physician-administered questionnaire. Immunologic studies were performed using radioimmunoassay. Spirometry and chest film were obtained. Workers with late asthma (LA) (n = 3), late respiratory systemic syndrome (LRSS) (n = 8), or both LRSS and asthma rhinitis (A/R) (n = 6) had improved symptoms, improved pulmonary functions, and lower total antibody against TM-HSA. Five of the 12 workers with A/R had improved symptoms, improved pulmonary functions, and lower IgE against TM-HSA, whereas seven continued to have moderate to severe symptoms, abnormal pulmonary functions, and elevated IgE against TM-HSA. There were no chest film findings in any group that were definitely attributed to TMA. Although TMA workers with LA or LRSS improve when moved to lower exposure jobs, only half of workers with A/R improve; elevated IgE against TM-HSA appears to be a marker for the subpopulation of workers with A/R that does not improve. JF - The American review of respiratory disease AU - Grammer, L C AU - Shaughnessy, M A AU - Henderson, J AU - Zeiss, C R AU - Kavich, D E AU - Collins, M J AU - Pecis, K M AU - Kenamore, B D AD - Department of Medicine, Northwestern University Medical School, Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 54 EP - 57 VL - 148 IS - 1 SN - 0003-0805, 0003-0805 KW - Phthalic Anhydrides KW - 0 KW - trimellitic anhydride KW - 80T61EUU7H KW - Abridged Index Medicus KW - Index Medicus KW - Asthma -- epidemiology KW - Immunologic Tests KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Middle Aged KW - Follow-Up Studies KW - Asthma -- diagnosis KW - Asthma -- chemically induced KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Immune System Diseases -- chemically induced KW - Occupational Exposure -- statistics & numerical data KW - Lung Diseases -- diagnosis KW - Lung Diseases -- chemically induced KW - Immune System Diseases -- diagnosis KW - Occupational Exposure -- adverse effects KW - Lung Diseases -- epidemiology KW - Immune System Diseases -- epidemiology KW - Occupational Diseases -- epidemiology KW - Phthalic Anhydrides -- adverse effects KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75800452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=A+clinical+and+immunologic+study+of+workers+with+trimellitic-anhydride-induced+immunologic+lung+disease+after+transfer+to+low+exposure+jobs.&rft.au=Grammer%2C+L+C%3BShaughnessy%2C+M+A%3BHenderson%2C+J%3BZeiss%2C+C+R%3BKavich%2C+D+E%3BCollins%2C+M+J%3BPecis%2C+K+M%3BKenamore%2C+B+D&rft.aulast=Grammer&rft.aufirst=L&rft.date=1993-07-01&rft.volume=148&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-28 N1 - Date created - 1993-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circadian cancer therapy. AN - 75800004; 8315438 AB - To review briefly the growing body of published data about circadian variation in cytotoxic drug metabolism and tissue sensitivity to chemotherapeutic agents. The suggestion that toxicity may be reduced and anticancer efficacy improved by administering antineoplastic agents at carefully selected times of the day was assessed. The medical literature describing molecular, cellular, and organismic time-keeping mechanisms, as well as circadian rhythms, in cytokinetic, pharmacokinetic, and pharmacodynamic parameters relevant to cancer chemotherapy, which support the predictable rhythmic relationship between dose and effect that occurs during each day, were reviewed. Advantages for optimal circadian scheduling have been demonstrated for diminishing side effects and increasing maximal safe dose-intensity of drugs of diverse class. The use of the predictable circadian relationship of dose and response provides another increment of progress in the treatment of cancer patients. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Hrushesky, W J AU - Bjarnason, G A AD - Albany Medical College, Stratton Veterans Administration Medical Center, NY 12208. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 1403 EP - 1417 VL - 11 IS - 7 SN - 0732-183X, 0732-183X KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Humans KW - Neoplasms, Experimental -- drug therapy KW - Neoplasms -- drug therapy KW - Circadian Rhythm -- physiology KW - Antineoplastic Agents -- administration & dosage KW - Neoplasms -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75800004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Circadian+cancer+therapy.&rft.au=Hrushesky%2C+W+J%3BBjarnason%2C+G+A&rft.aulast=Hrushesky&rft.aufirst=W&rft.date=1993-07-01&rft.volume=11&rft.issue=7&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-27 N1 - Date created - 1993-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat. AN - 75856685; 8338921 AB - The effects of blood pressure reduction on cyclosporine nephrotoxicity were studied over 12 months in four groups of rats. Group 1 received no drugs and served as controls. Groups 2, 3, and 4 received cyclosporine (CyA), approximately 9 mg/kg.day, in their food. In addition, Group 3 received enalapril and Group 4 received minoxidil, hydrochlorothiazide, and reserpine. Time-averaged monthly systolic blood pressure was equal in Groups 1 and 2 (136 +/- 1 and 135 +/- 1 mm Hg, respectively). Antihypertensive agents reduced average systolic blood pressure in Groups 3 and 4 (116 +/- 1 and 117 +/- 1 mm Hg, respectively). Morphometric studies showed that 12 months of CyA treatment caused interstitial fibrosis with an increase in the fractional volume of cortical interstitium (VvInt: Group 2, 20 +/- 1%; Group 1, 11 +/- 1%) and a reduction in mean glomerular volume (VG. Group 2, (2.00 +/- 0.06) x 10(6) mu 3; Group 1, (2.48 +/- 0.06) x 10(6) mu 3). These structural changes were accompanied by a significant reduction in GFR (Group 2, 2.27 +/- 0.10 mL/min; Group 1, 2.76 +/- 0.10 mL/min). Cotreatment with enalapril reduced interstitial fibrosis (VvInt, 14 +/- 1%) and maintained VG (2.23 +/- 0.08 x 10(6) mu 3) and GFR (2.56 +/- 0.08 mL/min) at near-normal values in Group 3. In contrast, the combination antihypertensive regimen increased the extent of interstitial fibrosis (VvInt, 24 +/- 1%) and further lowered VG (1.72 +/- 0.05 x 10(6) mu 3) and GFR (1.72 +/- 0.05 mL/min) in Group 4. These results show that sustained treatment with a moderate dose of CyA causes interstitial fibrosis and impairs renal function in rats. The administration of enalapril, but not minoxidil, reserpine, and hydrochlorothiazide, limits renal injury in this model. JF - Journal of the American Society of Nephrology : JASN AU - Lafayette, R A AU - Mayer, G AU - Meyer, T W AD - Department of Medicine, Palo Alto Veterans Administration Medical Center, CA. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 1892 EP - 1899 VL - 3 IS - 12 SN - 1046-6673, 1046-6673 KW - Antihypertensive Agents KW - 0 KW - Enalapril KW - 69PN84IO1A KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Proteinuria -- urine KW - Glomerular Filtration Rate -- drug effects KW - Antihypertensive Agents -- pharmacology KW - Systole KW - Enalapril -- pharmacology KW - Male KW - Cyclosporine -- blood KW - Cyclosporine -- adverse effects KW - Kidney -- pathology KW - Blood Pressure KW - Kidney -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75856685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=The+effects+of+blood+pressure+reduction+on+cyclosporine+nephrotoxicity+in+the+rat.&rft.au=Lafayette%2C+R+A%3BMayer%2C+G%3BMeyer%2C+T+W&rft.aulast=Lafayette&rft.aufirst=R&rft.date=1993-06-01&rft.volume=3&rft.issue=12&rft.spage=1892&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-31 N1 - Date created - 1993-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. AN - 75845505; 8333602 AB - Alcohol abuse leads to osteopenia and fractures. Epidemiological evidence suggests that older alcoholics are at substantially greater risk of fractures than younger alcoholics. To examine the interaction of age and alcohol abuse on bone mineral homeostasis, we studied 27 subjects with a history of 10 more years of alcohol abuse ranging in age from 26-68 years. They were evaluated for disordered bone mineral homeostasis by assessing bone density (by quantitative computed tomography of the lumbar spine), histomorphometry of a transcortical biopsy from the iliac crest, serum levels of vitamin D metabolites and parathyroid hormone, and serum and urine levels of bone minerals. Seventeen of the subjects were found to have spinal compression fractures by routine radiologic procedures. The older the subject the more likely the subject was to have such a fracture. Bone densitometry indicated a marked reduction in spinal bone density with 15 subjects below 2 SD of normal aged-matched controls. Bone density fell sharply with the age of the subject. Histomorphometry of iliac crest bone biopsies revealed no evidence of osteomalacia, but total resorption surfaces were increased. Consistent with the lack of osteomalacia were the normal levels of the vitamin D metabolites. The increased total resorption surfaces were correlated with high normal or elevated levels of parathyroid hormone as indicated both by radioimmunoassay and by urinary cAMP levels. Bone formation and active bone resorption (resorption surfaces containing osteoclasts) did not correlate with parathyroid hormone levels, however, but correlated negatively with age.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Bikle, D D AU - Stesin, A AU - Halloran, B AU - Steinbach, L AU - Recker, R AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 690 EP - 695 VL - 17 IS - 3 SN - 0145-6008, 0145-6008 KW - Parathyroid Hormone KW - 0 KW - Vitamin D KW - 1406-16-2 KW - Index Medicus KW - Space life sciences KW - Bone Density -- drug effects KW - Age Factors KW - Humans KW - Vitamin D -- blood KW - Adult KW - Fractures, Spontaneous -- blood KW - Bone Density -- physiology KW - Aged KW - Middle Aged KW - Spinal Fractures -- blood KW - Male KW - Bone Remodeling -- drug effects KW - Bone Remodeling -- physiology KW - Bone Diseases, Metabolic -- blood KW - Parathyroid Hormone -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75845505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Symptom+reduction+and+sobriety+in+the+male+alcoholic.&rft.au=Denney%2C+M+R%3BBaugh%2C+J+L&rft.aulast=Denney&rft.aufirst=M+R&rft.date=1992-11-01&rft.volume=27&rft.issue=11&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-19 N1 - Date created - 1993-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pneumonia, aseptic meningitis, and leukopenia in a 28-year-old man. AN - 75842330; 8329513 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mathisen, G E AU - Weiss, P J AU - Kennedy, C A AD - Infectious Diseases Section, Sepulveda Veterans Administration Medical Center, California. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 809 EP - 815 VL - 16 IS - 6 SN - 1058-4838, 1058-4838 KW - Index Medicus KW - Animals KW - Diagnosis, Differential KW - Ehrlichiosis -- etiology KW - Humans KW - Adult KW - Ehrlichiosis -- diagnosis KW - Bites and Stings -- complications KW - Ticks KW - Male KW - Meningitis, Aseptic -- diagnosis KW - Pneumonia -- diagnosis KW - Meningitis, Aseptic -- etiology KW - Leukopenia -- diagnosis KW - Pneumonia -- etiology KW - Leukopenia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75842330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=proceeding&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Pneumonia%2C+aseptic+meningitis%2C+and+leukopenia+in+a+28-year-old+man.&rft.au=Mathisen%2C+G+E%3BWeiss%2C+P+J%3BKennedy%2C+C+A&rft.aulast=Mathisen&rft.aufirst=G&rft.date=1993-06-01&rft.volume=16&rft.issue=6&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-17 N1 - Date created - 1993-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of morning or bedtime insulin with and without glyburide in secondary sulfonylurea failure. AN - 75841492; 8325203 AB - New treatment options are needed for glycemic control in NIDDM. We evaluated the effects of bedtime or morning insulin treatment, combined with daytime glyburide or given alone. Twenty-nine male patients with NIDDM, mean age 63 +/- 1.7 yr, body weight 124 +/- 2.98% of DBW, received a maximum glyburide dose (20 mg/day) for a minimum of 6 wk, to confirm sulfonylurea failure. Human lente insulin was added for 12 wk either AM (n = 14) or HS (n = 15) and adjusted to obtain fasting euglycemia (FPG; combination treatment phase). Glyburide was then stopped, and insulin was continued for 6 wk, aiming for normal FPG (insulin phase). After combination treatment phase, FPG decreased (P < 0.02) from 12.43 +/- 0.68 to 5.73 +/- 0.65 mM (AM) and from 12.68 +/- 0.76 to 5.51 +/- 0.48 mM (HS) (AM vs. HS, NS). Postbreakfast, presupper, and 0200 AM plasma glucose levels fell equally (P < 0.02) except for 1-h postprandial (AM 12.46 +/- 0.51 mM, HS 10.88 +/- 0.62 mM, AM vs. HS, P < 0.1). Mean HBA1c fell similarly in both AM and HS groups. At 2 wk of the insulin phase, FPG was higher in AM than HS, 9.8 +/- 0.76 vs. 7.56 +/- 0.7 mM (P < 0.1). At the end of insulin phase, plasma glucose levels were similar to the end of combination treatment phase, but the insulin dose had to be raised in AM by 39% (P < 0.02) and HS by 30% (P < 0.05). After the combination treatment phase, fasting C-peptide was significantly suppressed in HS group only, from 1.22 +/- 0.12 to 0.82 +/- 0.09 nM (P < 0.02). At the end of insulin phase, fasting C-peptide was further suppressed in both groups, but 2-h postprandial C-peptide levels decreased significantly in AM group only, from 1.85 +/- 0.23 to 1.42 +/- 0.13 nM (P < 0.02). Triglycerides and total and HDL cholesterol did not change significantly after either combination treatment phase or insulin phase. Mean weight gain was 6.5 lb during combination treatment phase (NS from baseline), without further change during insulin phase. Hypoglycemic reactions, all mild, were recorded at a rate of 1.35/patient in the AM group and 0.4/patient in the HS group (P < 0.025). Normal fasting glycemia and near-normal postprandial glucose profile could be obtained with combination therapy in NIDDM. Results were similar if insulin, alone or in combination with glyburide, was given before breakfast or at bedtime, but hypoglycemic reactions were more common with conventional morning insulin injections. JF - Diabetes care AU - Soneru, I L AU - Agrawal, L AU - Murphy, J C AU - Lawrence, A M AU - Abraira, C AD - Diabetes Research Laboratory, Hines Veterans Administration Hospital, Illinois 60141. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 896 EP - 901 VL - 16 IS - 6 SN - 0149-5992, 0149-5992 KW - Blood Glucose KW - 0 KW - C-Peptide KW - Hemoglobin A, Glycosylated KW - Insulin, Long-Acting KW - Recombinant Proteins KW - Glyburide KW - SX6K58TVWC KW - Index Medicus KW - Drug Administration Schedule KW - Hemoglobin A, Glycosylated -- analysis KW - C-Peptide -- blood KW - Humans KW - Aged KW - Fasting KW - Hypoglycemia -- chemically induced KW - Drug Therapy, Combination KW - Adult KW - Middle Aged KW - Time Factors KW - Recombinant Proteins -- therapeutic use KW - Male KW - Recombinant Proteins -- administration & dosage KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Insulin, Long-Acting -- administration & dosage KW - Glyburide -- adverse effects KW - Blood Glucose -- metabolism KW - Glyburide -- therapeutic use KW - Diabetes Mellitus, Type 2 -- blood KW - Insulin, Long-Acting -- therapeutic use KW - Insulin, Long-Acting -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75841492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Comparison+of+morning+or+bedtime+insulin+with+and+without+glyburide+in+secondary+sulfonylurea+failure.&rft.au=Soneru%2C+I+L%3BAgrawal%2C+L%3BMurphy%2C+J+C%3BLawrence%2C+A+M%3BAbraira%2C+C&rft.aulast=Soneru&rft.aufirst=I&rft.date=1993-06-01&rft.volume=16&rft.issue=6&rft.spage=896&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-06 N1 - Date created - 1993-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acidic and basic fibroblast growth factor mRNAs are increased in striatum following MPTP-induced dopamine neurofiber lesion: assay by quantitative PCR. AN - 75837332; 7686995 AB - Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF), the two best characterized members of a growing family of heparin-binding growth factors, have been shown to affect both survival of cultured neurons and regeneration of nerve terminals when applied exogenously. The endogenous expression of these growth factors in response to brain injury is not well understood. We have utilized the Swiss-Webster mouse, treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and a quantitative polymerase chain reaction assay to examine changes in endogenous synthesis of mRNA for both aFGF and bFGF in the striatum and substantia nigra. We have found that MPTP treatment results in a loss of 95% of dopaminergic function and is accompanied by an increase in expression of both aFGF and bFGF in the striatum at 1 week post-lesion. After 5 weeks, the terminals appear to be regenerating and FGF mRNA expression has returned to control levels. These results suggest that cellular reaction to chemical lesion in the brain may involve changes in growth factor expression, including both aFGF and bFGF. JF - Brain research. Molecular brain research AU - Leonard, S AU - Luthman, D AU - Logel, J AU - Luthman, J AU - Antle, C AU - Freedman, R AU - Hoffer, B AD - Denver Veterans Administration Medical Center, CO. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 275 EP - 284 VL - 18 IS - 4 SN - 0169-328X, 0169-328X KW - RNA, Messenger KW - 0 KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Fibroblast Growth Factor 1 KW - 104781-85-3 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Substantia Nigra -- metabolism KW - Polymerase Chain Reaction KW - Nerve Fibers -- drug effects KW - Animals KW - Base Sequence KW - Molecular Sequence Data KW - Mice KW - Immunohistochemistry KW - Corpus Striatum -- metabolism KW - RNA, Messenger -- drug effects KW - Fibroblast Growth Factor 2 -- genetics KW - Dopamine -- physiology KW - Corpus Striatum -- drug effects KW - RNA, Messenger -- biosynthesis KW - Fibroblast Growth Factor 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75837332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Molecular+brain+research&rft.atitle=Acidic+and+basic+fibroblast+growth+factor+mRNAs+are+increased+in+striatum+following+MPTP-induced+dopamine+neurofiber+lesion%3A+assay+by+quantitative+PCR.&rft.au=Leonard%2C+S%3BLuthman%2C+D%3BLogel%2C+J%3BLuthman%2C+J%3BAntle%2C+C%3BFreedman%2C+R%3BHoffer%2C+B&rft.aulast=Leonard&rft.aufirst=S&rft.date=1993-06-01&rft.volume=18&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Molecular+brain+research&rft.issn=0169328X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States. AN - 75770709; 8509575 AB - Patients with latex sensitivity and latex antigens from the United States and Finland, two countries where allergic reactions to latex have been widely reported, were evaluated to determine the spectrum of immune responses. Sera from 27 patients from Finland and 18 from the United States with latex allergy and control sera from nonsensitive individuals were studied for latex-specific IgE antibodies. Four antigen preparations were used: two extracted from gloves and one each extracted from rubber tree sap from Malaysia and India. All 45 patients had skin prick test results that were positive to latex antigens, and all sera were evaluated by enzyme-linked immunosorbent assay (ELISA) with the various antigens. There were considerable differences in the reactivity of patient sera with the different antigens. Only 50% of the sera from patients with latex allergy from Finland demonstrated significant levels of IgE to latex as determined by enzyme-linked immunosorbent assay. These patients showed more reactivity with rubber tree sap antigens than with glove antigens. However, 72% of the patients from the United States demonstrated antibodies to latex, and no marked differences were noted between the antigen extracts. The results indicate that reagents such as rubber tree sap, which contain multiple clinically significant antigenic components, should be included in evaluation of latex allergy and that differences in patient populations may result in serologic variances. JF - The Journal of allergy and clinical immunology AU - Kurup, V P AU - Kelly, K J AU - Turjanmaa, K AU - Alenius, H AU - Reunala, T AU - Palosuo, T AU - Fink, J N AD - Zablocki Veterans Administration Medical Center, Department of Medicine, Medical College of Wisconsin, Milwaukee 53295-1000. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 1128 EP - 1134 VL - 91 IS - 6 SN - 0091-6749, 0091-6749 KW - Antigens KW - 0 KW - Latex KW - Immunoglobulin E KW - 37341-29-0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Finland KW - Skin Tests KW - Humans KW - Adult KW - Middle Aged KW - Anaphylaxis -- immunology KW - Male KW - Female KW - Latex -- adverse effects KW - Dermatitis, Allergic Contact -- immunology KW - Hypersensitivity, Immediate -- immunology KW - Immunoglobulin E -- blood KW - Antigens -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75770709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Immunoglobulin+E+reactivity+to+latex+antigens+in+the+sera+of+patients+from+Finland+and+the+United+States.&rft.au=Kurup%2C+V+P%3BKelly%2C+K+J%3BTurjanmaa%2C+K%3BAlenius%2C+H%3BReunala%2C+T%3BPalosuo%2C+T%3BFink%2C+J+N&rft.aulast=Kurup&rft.aufirst=V&rft.date=1993-06-01&rft.volume=91&rft.issue=6&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-09 N1 - Date created - 1993-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thalamic infarction secondary to cervical manipulation. AN - 85223560; pmid-8489368 AB - Vertebrobasilar infarction is a well documented complication of cervical manipulation. A commonly proposed pathogenesis is an intimal tear of the vertebral artery leading to cerebellar and other posterior fossa lesions. However, there have been no cases of thalamic infarct reported. This case demonstrates a thalamic infarction concurrent with brainstem and cerebellar infarction secondary to cervical manipulation and intimal tearing of the vertebral artery. Immediately following manipulation, the patient developed nystagmus, quadriparesis, and a speech deficit. After an aggressive course of in-patient rehabilitation, the patient progressed to a community ambulator with deficits in speech and perception. This case demonstrates one of the inherent risks associated with repetitive forceful cervical manipulation. JF - Archives of Physical Medicine and Rehabilitation AU - Sinel, M AU - Smith, D AD - Department of Physical Medicine and Rehabilitation, Veterans Administration Medical Center, West Los Angeles, CA. PY - 1993 SP - 543 EP - 546 VL - 74 IS - 5 SN - 0003-9993, 0003-9993 KW - Magnetic Resonance Imaging KW - Cerebral Infarction KW - Human KW - Thalamic Diseases KW - Adult KW - Manipulation, Orthopedic KW - Vertebral Artery KW - Tomography, X-Ray Computed KW - Case Report KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Thalamic+infarction+secondary+to+cervical+manipulation.&rft.au=Sinel%2C+M%3BSmith%2C+D&rft.aulast=Sinel&rft.aufirst=M&rft.date=1993-05-01&rft.volume=74&rft.issue=5&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Quinolone therapy in intensive care unit settings. AN - 76306426; 7922402 AB - Three fluoroquinolone antimicrobials (norfloxacin, ciprofloxacin, and ofloxacin) could be used to prevent or treat infections in intensive care unit patients. All of these fluoroquinolones are particularly active against Gram-negative, aerobic bacteria. However, the pharmacokinetic properties of each fluoroquinolone are unique. Furthermore, only ciprofloxacin and ofloxacin are available for intravenous administration. Based on current, available information: a) fluoroquinolones are not endorsed for inclusion in selective decontamination protocols; b) fluoroquinolones are endorsed for empiric therapy of suspected Gram-negative bacterial infections based on local microorganism susceptibility patterns; and c) fluoroquinolones are endorsed for treatment of microbiologically documented infections based on their distribution properties, low rate of toxicity, and rapid bactericidal effect. JF - New horizons (Baltimore, Md.) AU - Beam, T R AD - Buffalo Veterans Administration Medical Center, State University of New York at Buffalo 14215. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 187 EP - 193 VL - 1 IS - 2 SN - 1063-7389, 1063-7389 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Ofloxacin KW - A4P49JAZ9H KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Administration, Oral KW - Drug Interactions KW - Infusions, Intravenous KW - Humans KW - Drug Resistance, Microbial KW - Clinical Trials as Topic KW - Aged KW - Tissue Distribution KW - Microbial Sensitivity Tests KW - Male KW - Clinical Protocols KW - Ofloxacin -- supply & distribution KW - Norfloxacin -- pharmacokinetics KW - Ciprofloxacin -- pharmacokinetics KW - Intensive Care Units KW - Gram-Negative Bacterial Infections -- drug therapy KW - Ciprofloxacin -- therapeutic use KW - Norfloxacin -- supply & distribution KW - Gram-Negative Bacterial Infections -- microbiology KW - Cross Infection -- microbiology KW - Cross Infection -- drug therapy KW - Norfloxacin -- therapeutic use KW - Ofloxacin -- therapeutic use KW - Ciprofloxacin -- supply & distribution KW - Ofloxacin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76306426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+horizons+%28Baltimore%2C+Md.%29&rft.atitle=Quinolone+therapy+in+intensive+care+unit+settings.&rft.au=Beam%2C+T+R&rft.aulast=Beam&rft.aufirst=T&rft.date=1993-05-01&rft.volume=1&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=New+horizons+%28Baltimore%2C+Md.%29&rft.issn=10637389&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-25 N1 - Date created - 1994-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of condom use among intravenous drug users. AN - 75809424; 8318179 AB - To examine the factors associated with condom use among a cohort of sexually active intravenous drug users (IVDU). Data were collected via personal interview at the fourth-month assessment point of a longitudinal study monitoring HIV infection and risk behaviors among IVDU. A community-based methadone clinic. A total of 158 sexually active heterosexual male and female IVDU, including both methadone patients and out-of-treatment individuals with a history of opiate abuse. We describe a new approach to identify the determinants of condom use. Previous studies have described subjects as either 'condom users' or 'condom non-users', using an individual's overall behavior as the unit of analysis. By analyzing condom use during the most recent sexual encounter, we avoided the problem of interpreting inconsistent condom use. Data were analyzed using forward stepwise logistic regression. Thirty-four per cent of the heterosexual subjects (n = 160) reported using a condom during their last sexual encounter. Being HIV-positive and having either a causal or commercial partner were each associated with increased probability of using a condom (odds ratio, 10.6, 4.4 and 12.1, respectively). No interactions with sex were found. Our results suggest that knowing that one is HIV-positive is an important determinant of condom use; HIV testing may therefore increase the use of condoms. In addition, interventions to change sexual behaviors may need to focus on the type of sexual partner. JF - AIDS (London, England) AU - Watkins, K E AU - Metzger, D AU - Woody, G AU - McLellan, A T AD - University of Pennsylvania/Veterans Administration Medical Center, Philadelphia. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 719 EP - 723 VL - 7 IS - 5 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - Population KW - AIDS/HIV KW - United States KW - Barrier Methods KW - Research Methodology KW - Contraceptive Usage--determinants KW - Sex Behavior KW - Contraceptive Methods KW - Developed Countries KW - Hiv Infections KW - Data Collection KW - Diseases KW - Family Planning KW - Iv Drug Users KW - North America KW - Americas KW - Research Report KW - Knowledge KW - Condom KW - Northern America KW - Contraception KW - Behavior KW - Viral Diseases KW - Risk Factors KW - Interviews KW - Pennsylvania KW - Drug Usage KW - Biology KW - Sexual Behavior KW - Risk-Taking KW - HIV Infections -- transmission KW - HIV Infections -- complications KW - Humans KW - HIV Infections -- prevention & control KW - Cohort Studies KW - Adult KW - Philadelphia -- epidemiology KW - Male KW - Female KW - Sexual Partners KW - Condoms -- utilization KW - Substance Abuse, Intravenous -- complications KW - Substance Abuse, Intravenous -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75809424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Determinants+of+condom+use+among+intravenous+drug+users.&rft.au=Watkins%2C+K+E%3BMetzger%2C+D%3BWoody%2C+G%3BMcLellan%2C+A+T&rft.aulast=Watkins&rft.aufirst=K&rft.date=1993-05-01&rft.volume=7&rft.issue=5&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-05 N1 - Date created - 1993-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Theophylline in the ambulatory treatment of chronic obstructive lung disease: resolving a controversy. AN - 75785021; 8513541 AB - Recent reports of a high frequency of theophylline toxicity, which usually occurs at theophylline blood levels > 20 micrograms/mL, coupled with the recent addition of metered-dose, inhaled anticholinergics to the beta-2 agonist inhalers already available for treatment of chronic obstructive pulmonary disease, has led some authors to suggest that theophylline should no longer be used in the ambulatory management of this disease. The author suggests an alternate approach to theophylline dosing as a means of resolving the current controversy. Because of the log-linear relationship between bronchodilation and blood level, little bronchodilator efficacy is lost by using a target therapeutic theophylline blood level of 10 +/- 2 micrograms/mL. This target provides a greater range between therapeutic and toxic blood levels than the 17 +/- 2 micrograms/mL therapeutic target blood level that has also been recommended. Because theophylline has a different mode of action than the sympathomimetic or anticholinergic drugs, it continues to have a useful place in the ambulatory management of chronic obstructive pulmonary disease. JF - Cleveland Clinic journal of medicine AU - Snider, G L AD - Boston Veterans Administration Medical Center, MA 01230. PY - 1993 SP - 197 EP - 201 VL - 60 IS - 3 SN - 0891-1150, 0891-1150 KW - Bronchodilator Agents KW - 0 KW - Theophylline KW - C137DTR5RG KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Bronchodilator Agents -- therapeutic use KW - Ambulatory Care KW - Theophylline -- pharmacokinetics KW - Theophylline -- therapeutic use KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75785021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Theophylline+in+the+ambulatory+treatment+of+chronic+obstructive+lung+disease%3A+resolving+a+controversy.&rft.au=Snider%2C+G+L&rft.aulast=Snider&rft.aufirst=G&rft.date=1993-05-01&rft.volume=60&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=08911150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychosocial factors, alcohol use, and hangover signs among social drinkers: a reappraisal. AN - 75761989; 8501466 AB - To reappraise a prior study of hangover signs and psychosocial factors among a sample of current drinkers, we excluded a subgroup termed Sobers, who report "never" being "tipsy, high or drunk." The non-sober current drinkers then formed the sample for this report (N = 1104). About 23% of this group reported no hangover signs regardless of their intake level or gender, and the rest showed no sex differences for any of 8 hangover signs reported. Using multiple regression, including ethanol, age and weight, it was found that psychosocial variables contributed independently in predicting to hangover for both men and women in this order: (1) guilt about drinking; (2) neuroticism; (3) angry or (4) depressed when high/drunk and (5) negative life events. For men only, ethanol intake was also significant; for women only, being younger and reporting first being high/drunk at a relatively earlier age were also predictors of the Hangover Sign Index (HSI). These multiple predictors accounted for 5-10 times more of the hangover variance than alcohol use alone: for men, R = 0.43, R2 = 19%; and for women, R = 0.46, R2 = 21%. The findings suggest that hangover signs are a function of age, sex, ethanol level and psychosocial factors. JF - Journal of clinical epidemiology AU - Harburg, E AU - Gunn, R AU - Gleiberman, L AU - DiFranceisco, W AU - Schork, A AD - Department of Epidemiology, School of Public Health, Veterans Administration Hospital, Ann Arbor, MI. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 413 EP - 422 VL - 46 IS - 5 SN - 0895-4356, 0895-4356 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Severity of Illness Index KW - Body Weight KW - Regression Analysis KW - Ethanol -- blood KW - Age Factors KW - Sex Factors KW - Humans KW - Male KW - Female KW - Alcoholic Intoxication -- psychology KW - Alcohol Drinking -- psychology KW - Alcoholic Intoxication -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Psychosocial+factors%2C+alcohol+use%2C+and+hangover+signs+among+social+drinkers%3A+a+reappraisal.&rft.au=Harburg%2C+E%3BGunn%2C+R%3BGleiberman%2C+L%3BDiFranceisco%2C+W%3BSchork%2C+A&rft.aulast=Harburg&rft.aufirst=E&rft.date=1993-05-01&rft.volume=46&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-01 N1 - Date created - 1993-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 60 Hz magnetic field acts as co-promoter in focus formation of C3H/10T1/2 cells. AN - 75761829; 8504489 AB - Disruption of communication between transformed cells and normal cells is involved in tumor promotion. We have tested the hypothesis that 60 Hz electromagnetic (EM) field exposures and a chemical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) are co-promoters that enhance focus formation of transformed cells in co-culture with normal cells. EM field exposures alone did not affect the growth curves of parental C3H/10T1/2 fibroblasts or daughter mutant cells, UV-TDTx10e. Furthermore, EM field exposures alone did not promote focus formation of mutant cells in co-culture with parental cells under the conditions tested. However, EM field exposures co-promoted with TPA by increasing focus formation in co-culture. Cell cultures were exposed to an EM field in custom-built solenoidal incubators. The field exposures were 1.0 Gauss in a schedule of 1 h epochs four times daily for 28 days. Video image analysis of three independent experiments showed that field-exposed cultures produced 1.9-fold more foci than sham-exposed cultures when treated with TPA. The total area of foci per dish increased 2.2-fold and the number of cells in stained foci increased 2.3-fold. In a TPA dose-response, focus formation began at 3 ng/ml with no difference between field-exposed and sham-exposed co-cultures. However, at the TPA concentrations of 10, 20, 40, 50 and 100 ng/ml EM field exposures enhanced focus formation by an average of 150%. This study suggests that chronic intermittent exposures to a 60 Hz EM field and a chemical tumor promoter influenced membrane-related events by co-promoting focus formation. JF - Carcinogenesis AU - Cain, C D AU - Thomas, D L AU - Adey, W R AD - Jerry L. Pettis Memorial Veterans Administration Medical Center, Research Service, Loma Linda, CA 92357. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 955 EP - 960 VL - 14 IS - 5 SN - 0143-3334, 0143-3334 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Fibroblasts -- drug effects KW - Animals KW - Video Recording KW - Fibroblasts -- pathology KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Mice KW - Fibroblasts -- radiation effects KW - Cell Line KW - Tetradecanoylphorbol Acetate -- toxicity KW - Magnetics KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=60+Hz+magnetic+field+acts+as+co-promoter+in+focus+formation+of+C3H%2F10T1%2F2+cells.&rft.au=Cain%2C+C+D%3BThomas%2C+D+L%3BAdey%2C+W+R&rft.aulast=Cain&rft.aufirst=C&rft.date=1993-05-01&rft.volume=14&rft.issue=5&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-06 N1 - Date created - 1993-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of antihypertensive and beta 1-adrenoceptor antagonist effect of nebivolol and atenolol in essential hypertension. AN - 75730895; 8098243 AB - dl-nebivolol is a new, chemically unique, selective beta 1-adrenoceptor antagonist, without sympathomimetic activity. In the present study, the antihypertensive and negative chronotropic effects of 5 and 10 mg once-daily nebivolol were compared to those of 50 and 100 mg once-daily atenolol in 25 white, male subjects with essential hypertension, using a double-blind, crossover design, and a parallel placebo-treated group of subjects (N = 7). 24 hours after dosing, sitting and standing diastolic and systolic blood pressures and heart rates (at rest and during submaximal exercise) were reduced to the same extent by nebivolol and atenolol. On a weight-for-weight basis, nebivolol is ten times more potent than atenolol. Nebivolol and atenolol also reduced 1-hour ambulatory plasma renin activity. Once-daily nebivolol is an effective antihypertensive beta-adrenoceptor antagonist. JF - Clinical and experimental hypertension (New York, N.Y. : 1993) AU - Simon, G AU - Johnson, M L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 501 EP - 509 VL - 15 IS - 3 SN - 1064-1963, 1064-1963 KW - Adrenergic beta-Antagonists KW - 0 KW - Antihypertensive Agents KW - Benzopyrans KW - Ethanolamines KW - Nebivolol KW - 030Y90569U KW - Atenolol KW - 50VV3VW0TI KW - Renin KW - EC 3.4.23.15 KW - Index Medicus KW - Renin -- blood KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Ethanolamines -- therapeutic use KW - Hypertension -- physiopathology KW - Benzopyrans -- therapeutic use KW - Hypertension -- blood KW - Atenolol -- therapeutic use KW - Benzopyrans -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Ethanolamines -- adverse effects KW - Adrenergic beta-Antagonists -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75730895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.atitle=Comparison+of+antihypertensive+and+beta+1-adrenoceptor+antagonist+effect+of+nebivolol+and+atenolol+in+essential+hypertension.&rft.au=Simon%2C+G%3BJohnson%2C+M+L&rft.aulast=Simon&rft.aufirst=G&rft.date=1993-05-01&rft.volume=15&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.issn=10641963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-11 N1 - Date created - 1993-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dextromethorphan and its combination with phenytoin facilitate kindling. AN - 75728079; 8492958 AB - We implanted 20 rats with bipolar electrodes and randomly distributed them into four groups that received intraperitoneal injections of phenytoin (PHT) (20 mg/kg), dextromethorphan (DM) (50 mg/kg), PHT+DM (20 and 50 mg/kg, respectively), or saline (C), 15 minutes before each daily stimulation. The number of stimulations needed to reach stage 3 seizures was 14.4 +/- 1.7 (C); 28 +/- 12 (PHT, p < 0.001); 6.2 +/- 3.9 (DM, p < 0.05); and 7.6 +/- 3.4 (PHT+DM, p < 0.05), suggesting that DM accelerated the expression of kindled seizures. Daily injections of DM and of DM+PHT without stimulation resulted in progressive seizure buildup to stage 3 in 4.8 +/- 6.2 (DM) or in 8 +/- 4.8 (DM+PHT) trials. We demonstrated savings in six kindled animals reinjected after 1 month. These results and previous experimental and clinical data suggest that DM may be epileptogenic when given repeatedly in high doses. JF - Neurology AU - Thompson, K W AU - Wasterlain, C G AD - Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 992 EP - 994 VL - 43 IS - 5 SN - 0028-3878, 0028-3878 KW - Phenytoin KW - 6158TKW0C5 KW - Dextromethorphan KW - 7355X3ROTS KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Hippocampus -- physiology KW - Hippocampus -- physiopathology KW - Electric Stimulation KW - Male KW - Hippocampus -- drug effects KW - Seizures -- chemically induced KW - Phenytoin -- pharmacology KW - Kindling, Neurologic -- drug effects KW - Seizures -- physiopathology KW - Dextromethorphan -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75728079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Dextromethorphan+and+its+combination+with+phenytoin+facilitate+kindling.&rft.au=Thompson%2C+K+W%3BWasterlain%2C+C+G&rft.aulast=Thompson&rft.aufirst=K&rft.date=1993-05-01&rft.volume=43&rft.issue=5&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-11 N1 - Date created - 1993-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 1994 Mar;44(3 Pt 1):582-3 [8179707] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells. AN - 75723525; 8489251 AB - To examine the effects of hyperglycemia on insulin signaling in A-10 vascular smooth muscle cells, cells were treated with extracellular D-glucose and effects of insulin were studied on the diacylglycerol-protein kinase C signaling system. A-10 cells specifically bound 125I-insulin, and insulin-like growth factor-I did not displace the label. 125I-insulin binding was unaltered under hyperglycemic conditions. To determine if insulin receptors were coupled to other insulin-regulated processes, diacylglycerol, protein kinase C, and glucose transport were evaluated. Insulin increased cellular diacylglycerol (DAG) levels which were also increased following glucose treatment and not further stimulated by insulin. The uptake of 2-[3H]deoxy-D-glucose (2-DOG) was stimulated by insulin and 12-O-tetradecanoyl phorbol 13-acetate (TPA). Insulin- and TPA-stimulated 2-[3H]DOG uptake was inhibited by a protein kinase inhibitor, staurosporine. Preincubation of cells with 500 nM TPA overnight resulted in the inhibition of insulin- and TPA-stimulated 2-[3H]DOG uptake. Protein kinase C activity was translocated from cytosolic to membrane fractions following insulin treatment. Overnight glucose (25 mM) treatment resulted in a 50% decrease in protein kinase C enzyme activity and > 90% decrease in protein kinase C beta immunoreactive levels. Protein kinase C activity and levels were not affected by osmotic control media containing mannitol. A-10 cells express GLUT4-type glucose transporters. Neither insulin-regulatable glucose transporter (GLUT4) mRNA nor GLUT4 protein levels were diminished by glucose. Significant decreases in insulin- and TPA-stimulated 2-[3H]DOG uptake occurred, however, with glucose. The down-regulation of protein kinase C beta and resultant inhibition of 2-[3H]DOG uptake by chronic glucose suggests a biochemical link between hyperglycemia and DAG-protein kinase C signaling in vascular smooth muscle cells. JF - Archives of biochemistry and biophysics AU - Cooper, D R AU - Khalakdina, A AU - Watson, J E AD - Research Service, J. A. Haley Veterans Administration Hospital, Tampa, Florida 33612. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 490 EP - 498 VL - 302 IS - 2 SN - 0003-9861, 0003-9861 KW - Alkaloids KW - 0 KW - Diglycerides KW - Glucose Transporter Type 4 KW - Insulin KW - Monosaccharide Transport Proteins KW - Muscle Proteins KW - Slc2a4 protein, rat KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Staurosporine KW - H88EPA0A3N KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Hyperglycemia -- metabolism KW - Biological Transport KW - Membranes -- metabolism KW - Rats KW - Protein Kinase C -- antagonists & inhibitors KW - Down-Regulation KW - Cell Compartmentation KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Alkaloids -- pharmacology KW - Monosaccharide Transport Proteins -- analysis KW - Cell Line KW - Deoxyglucose -- metabolism KW - Diglycerides -- metabolism KW - Signal Transduction -- physiology KW - Glucose -- pharmacology KW - Glucose -- metabolism KW - Signal Transduction -- drug effects KW - Muscle, Smooth, Vascular -- drug effects KW - Insulin -- metabolism KW - Insulin -- pharmacology KW - Muscle, Smooth, Vascular -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75723525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Chronic+effects+of+glucose+on+insulin+signaling+in+A-10+vascular+smooth+muscle+cells.&rft.au=Cooper%2C+D+R%3BKhalakdina%2C+A%3BWatson%2C+J+E&rft.aulast=Cooper&rft.aufirst=D&rft.date=1993-05-01&rft.volume=302&rft.issue=2&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-04 N1 - Date created - 1993-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical Course of Alcoholism in 636 Male Inpatients AN - 61322906; 9404366 AB - The rate of & age of first occurrence of quantifiable symptoms of alcohol dependence are examined through structured interviews with 636 male alcoholic inpatients at a Veteran's Administration treatment program in San Diego, CA. Nearly 75% of the Ss began to display severe alcohol-related symptoms by their late 20s. In the early to mid-30s, more serious signs of alcohol's interference with life functioning appeared, eg, blackouts, alcohol withdrawal, & arrest for public intoxication or drunk driving. By the mid-30s, perception of loss of control occurred, accompanied by intensification of social & employment difficulties & deterioration of health. The late 30s to early 40s brought signs of serious long-term consequences of alcohol use & other difficulties. Similar patterns of alcohol dependence were found after controlling for age of onset, family history of alcoholism, & other psychiatric disorders. 2 Tables, 27 References. D. Generoli JF - The American Journal of Psychiatry AU - Schuckit, Marc A AU - Smith, Tom L AU - Anthenelli, Robert AU - Irwin, Michael AD - Dept Psychiatry Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 786 EP - 792 VL - 150 IS - 5 SN - 0002-953X, 0002-953X KW - alcoholism's clinical course, males KW - interview data KW - middle-aged inpatients, Veteran's Administration treatment program, San Diego, California KW - Symptoms KW - Males KW - Alcoholism KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61322906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Clinical+Course+of+Alcoholism+in+636+Male+Inpatients&rft.au=Schuckit%2C+Marc+A%3BSmith%2C+Tom+L%3BAnthenelli%2C+Robert%3BIrwin%2C+Michael&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1993-05-01&rft.volume=150&rft.issue=5&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Alcoholism; Males; Symptoms ER - TY - JOUR T1 - In-Hospital Respite as a Moderator of Caregiver Stress AN - 1761711338; 199401838 AB - Telephone survey data on family caregiver (N = 22) stress obtained 3 days before, during, & 14 days following respite (short-term patient stays in a hospital) suggest that stress was moderated by an in-hospital respite program for patients with Alzheimer's disease. Results indicate that, although short-term benefits may be realized for caregivers, in-hospital Alzheimer's respite care may present a particular risk for patient decline, adverse events, & institutionalization. 1 Table, 19 References. Adapted from the source document. JF - Health and Social Work AU - Larkin, John P AU - Hopcroft, Barbara Most AD - Social Work Services Veterans Administration Medical Center, Hampton VA 23667 Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 132 EP - 138 VL - 18 IS - 2 SN - 0360-7283, 0360-7283 KW - caregiver stress reduction, in-hospital respite care's effect, Alzheimer patients KW - Psychological Stress KW - Caregivers KW - Family Relations KW - Hospitalization KW - Treatment Programs KW - Alzheimer's Disease KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761711338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+and+Social+Work&rft.atitle=In-Hospital+Respite+as+a+Moderator+of+Caregiver+Stress&rft.au=Larkin%2C+John+P%3BHopcroft%2C+Barbara+Most&rft.aulast=Larkin&rft.aufirst=John&rft.date=1993-05-01&rft.volume=18&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Health+and+Social+Work&rft.issn=03607283&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Caregivers; Family Relations; Alzheimer's Disease; Treatment Programs; Hospitalization; Psychological Stress ER - TY - JOUR T1 - Rapid degradation of NAD by retinoic acid-differentiated HL-60 granulocyte membranes prevents ADP ribosylation. AN - 75715180; 8387292 AB - Pertussis and cholera toxins failed to ADP-ribosylate G alpha s and G alpha i in membranes isolated from retinoic acid-differentiated HL-60 granulocytes, although G alpha i subunits were present. NAD was rapidly degraded in the presence of these membranes, primarily to ADP-ribose, to less than 10% of initial activity by 5 min. Metabolism of NAD was heat labile and inhibited by NADP, but not by imidazole or isonicotinic acid hydrazine. Pertussis toxin uncoupled LTB4 receptors from G proteins in intact retinoic acid-differentiated HL-60 cells. Retinoic acid differentiation stimulates expression of a unique NAD-glycohydrolase activity in HL-60 granulocytes which prevents ADP-ribosylation in isolated membranes, but not intact cells. JF - Biochemical and biophysical research communications AU - McLeish, K R AU - Jacobs, A A AD - Veterans Administration Medical Center, Louisville, KY. Y1 - 1993/04/30/ PY - 1993 DA - 1993 Apr 30 SP - 870 EP - 878 VL - 192 IS - 2 SN - 0006-291X, 0006-291X KW - Virulence Factors, Bordetella KW - 0 KW - NAD KW - 0U46U6E8UK KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Tretinoin KW - 5688UTC01R KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - NAD+ Nucleosidase KW - EC 3.2.2.5 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Virulence Factors, Bordetella -- pharmacology KW - Tretinoin -- pharmacology KW - NAD+ Nucleosidase -- metabolism KW - Cells, Cultured KW - Cell Membrane -- drug effects KW - Humans KW - GTP-Binding Proteins -- metabolism KW - Cholera Toxin -- pharmacology KW - Cell Membrane -- metabolism KW - Cell Differentiation -- drug effects KW - NAD -- metabolism KW - Granulocytes -- metabolism KW - Granulocytes -- drug effects KW - Adenosine Diphosphate Ribose -- metabolism KW - Granulocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75715180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Rapid+degradation+of+NAD+by+retinoic+acid-differentiated+HL-60+granulocyte+membranes+prevents+ADP+ribosylation.&rft.au=McLeish%2C+K+R%3BJacobs%2C+A+A&rft.aulast=McLeish&rft.aufirst=K&rft.date=1993-04-30&rft.volume=192&rft.issue=2&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-01 N1 - Date created - 1993-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy. AN - 75643893; 8463294 AB - Considerable effort is being made to design anti-viral drugs for the human immunodeficiency virus type 1 (HIV-1) infection process. Some of this work has focused on CD4 protein, the HIV-1 receptor on T helper lymphocytes. One drug that binds to CD4 protein and inhibits both viral infection and growth is DIDS (4,4'-diisothiocyanato-2,2'-stilbenedisulfonate). DIDS is best known for its ability to inhibit erythrocyte band 3 anion exchange. Although the antiviral potency of DIDS is evident in vitro (IC50 approximately 30 microM), intravenous administration of DIDS should not be effective owing to the large number of band 3 molecules present on the red blood cell membrane (approximately 10(6)/cell), and to the very small Kd for DIDS binding to band 3 (approximately 30 nM). Therefore, we sought to identify other anion transport inhibitors that would bind weakly to band 3, but tightly to CD4 protein, and that could be administered to humans without significant toxic side effects. On the basis of our previous work with band 3 (Salhany, J. M., Rauenbuehler, P. B., and Sloan, R. L. (1987) J. Biol. Chem. 262, 15965-15973), we elected to study the binding of pyridoxal 5'-phosphate (PLP) to soluble CD4 protein. We have discovered that PLP binds surprisingly tightly to soluble CD4 protein (Kd = 45 microM), with a stoichiometry of about 1 mol of PLP/mol of protein. Furthermore, PLP binding was found to be competitive with DIDS for its binding site on soluble CD4 protein. These results suggest that PLP may be an effective anti-viral agent for the HIV-1 infection process. JF - The Journal of biological chemistry AU - Salhany, J M AU - Schopfer, L M AD - Veterans Administration Medical Center, Omaha, Nebraska. Y1 - 1993/04/15/ PY - 1993 DA - 1993 Apr 15 SP - 7643 EP - 7645 VL - 268 IS - 11 SN - 0021-9258, 0021-9258 KW - Antigens, CD4 KW - 0 KW - Recombinant Proteins KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid KW - 27816-59-7 KW - Pyridoxal Phosphate KW - 5V5IOJ8338 KW - 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid KW - Q1O6DSW23R KW - Index Medicus KW - AIDS/HIV KW - Recombinant Proteins -- isolation & purification KW - Animals KW - Spectrometry, Fluorescence KW - Transfection KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Humans KW - CHO Cells KW - Spectrophotometry KW - Protein Binding KW - Cricetinae KW - HIV-1 -- metabolism KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid -- metabolism KW - Antigens, CD4 -- isolation & purification KW - Antigens, CD4 -- genetics KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid -- analogs & derivatives KW - Pyridoxal Phosphate -- metabolism KW - Antigens, CD4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75643893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pyridoxal+5%27-phosphate+binds+specifically+to+soluble+CD4+protein%2C+the+HIV-1+receptor.+Implications+for+AIDS+therapy.&rft.au=Salhany%2C+J+M%3BSchopfer%2C+L+M&rft.aulast=Salhany&rft.aufirst=J&rft.date=1993-04-15&rft.volume=268&rft.issue=11&rft.spage=7643&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-06 N1 - Date created - 1993-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of human pancreatic cancer cell-induced hepatic metastasis in nude mice by dipyridamole and its analog RA-233. AN - 75632671; 8453569 AB - Several studies have provided evidence suggesting that platelets play a key role in tumor metastasis. A number of antiplatelet agents have been used to prevent tumor metastasis in animal models and humans. Antiplatelet agents, dipyridamole (adenosine transport inhibitor), and RA-233 (inhibitor of cAMP PDE) were used to prevent tumor-cell-platelet interactions both in in vitro and in vivo systems; however, the data were not very conclusive. Our studies used dipyridamole and RA-233 alone and in combination to investigate their effects on human pancreatic tumor cells (RWP-2)-induced platelet aggregation in human blood and on hepatic metastasis in nude mice. To examine effects of dipyridamole and RA-233 on liver metastasis, the tumor cells (RWP-2) were injected intrasplenically in nude mice grouped into control, dipyridamole (8 mg/kg), RA-233 (8 mg/kg), and dipyridamole plus RA-233 (8 mg/kg each). The agents were administered intraperitoneally 1 hour before and 24 hours after the tumor cell injection. When dipyridamole and RA-233 were used alone, only weak to moderate effects were seen on RWP-2 tumor cell-induced platelet aggregation. However, these agents, when combined, strongly inhibited the tumor cell-induced aggregation in human platelet-rich plasma. In tumor metastasis experiments, reductions of approximately 70% in hepatic nodules and 90% in surface area occupied by the tumor were seen with the combination treatment (dipyridamole plus RA-233) as compared with the control group of mice. This study suggests that the combination of dipyridamole and RA-233 provides an effective intervention for the antithrombotic approach to the treatment of cancer metastases. JF - Cancer AU - Tzanakakis, G N AU - Agarwal, K C AU - Vezeridis, M P AD - Surgical Service Veterans Administration Medical Center, Providence, Rhode Island. Y1 - 1993/04/15/ PY - 1993 DA - 1993 Apr 15 SP - 2466 EP - 2471 VL - 71 IS - 8 SN - 0008-543X, 0008-543X KW - Mopidamol KW - 4Q0IWP8B8O KW - Dipyridamole KW - 64ALC7F90C KW - Adenosine KW - K72T3FS567 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Animals KW - Tumor Cells, Cultured KW - Adenosine -- blood KW - Humans KW - Mice, Nude KW - Mice KW - Drug Synergism KW - Liver Neoplasms -- prevention & control KW - Pancreatic Neoplasms -- blood KW - Mopidamol -- pharmacology KW - Liver Neoplasms -- secondary KW - Dipyridamole -- pharmacology KW - Platelet Aggregation -- drug effects KW - Liver Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75632671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Prevention+of+human+pancreatic+cancer+cell-induced+hepatic+metastasis+in+nude+mice+by+dipyridamole+and+its+analog+RA-233.&rft.au=Tzanakakis%2C+G+N%3BAgarwal%2C+K+C%3BVezeridis%2C+M+P&rft.aulast=Tzanakakis&rft.aufirst=G&rft.date=1993-04-15&rft.volume=71&rft.issue=8&rft.spage=2466&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-22 N1 - Date created - 1993-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Auditory sensory gating in the rat hippocampus: modulation by brainstem activity. AN - 85230179; pmid-8481808 AB - Auditory stimuli repeated at short intervals result in diminished evoked responses recorded from the skull surface and from the hippocampus in the rat. The rat has been used to model diminished responses to repeated auditory stimuli--a phenomenon seen in normal human subjects, but often absent in schizophrenics. In this study, we examined the neural circuitry involved in the processing and gating of auditory responses recorded from the hippocampus of the rat. Evoked potentials and single neuron activity with diminished responses to the second of paired tones were recorded in the brainstem reticular formation in the paragigantocellular region at the caudal level of the pons, but diminished responses were not observed in the primary auditory relay nuclei. Electrical stimulation of this region of the brainstem reticular formation was able to substitute for the first, or conditioning, auditory tone to produce sensory gating of the response to the second, or test, tone when recording from the hippocampus. Stimulation of the auditory nuclei up to the level of the lateral lemniscus, but not the superior colliculus, was also able to substitute for an auditory stimulus to produce sensory gating in the hippocampus. The gating of hippocampal responses to auditory stimuli may thus involve pathways which branch from the lemniscal auditory pathway at the level of the lateral lemniscus and ascend to the hippocampus via the brainstem reticular formation. JF - Brain Research AU - Bickford, P C AU - Luntz-Leybman, V AU - Freedman, R AD - Veterans Administration Medical Center, Denver, CO 80220. PY - 1993 SP - 33 EP - 38 VL - 607 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Rats KW - Rats, Sprague-Dawley KW - Conditioning (Psychology) KW - Evoked Potentials, Auditory, Brain Stem KW - Hippocampus KW - Animal KW - Brain Stem KW - Acoustic Stimulation KW - Histocytochemistry KW - Electric Stimulation KW - Reticular Formation KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Auditory+sensory+gating+in+the+rat+hippocampus%3A+modulation+by+brainstem+activity.&rft.au=Bickford%2C+P+C%3BLuntz-Leybman%2C+V%3BFreedman%2C+R&rft.aulast=Bickford&rft.aufirst=P&rft.date=1993-04-01&rft.volume=607&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Significance of tumor thickness in soft palate carcinoma. AN - 85196852; pmid-8459747 AB - Tumor thickness is an important prognostic factor in tumors outside of the upper aerodigestive tract, such as cutaneous melanoma, colorectal carcinoma, and cervical carcinoma. Some studies have also suggested that tumor thickness may have similar prognostic value in the upper aerodigestive tract. This study examined the relationship between tumor thickness (measured with an ocular micrometer) and nodal disease and that between tumor thickness and survival in 44 patients with soft palate epidermoid carcinoma. There was a significant correlation between tumor thickness and nodal disease. None of the 24 lesions less than or equal to 2.86 mm had cervical adenopathy. All of the 15 lesions greater than or equal to 3.12 mm had palpable adenopathy. Tumor thickness correlated more directly with nodal disease than did T stage. Thicker lesions were associated with poorer survival. Tumor thickness is an important parameter in the head and neck and deserves further study. JF - The Laryngoscope AU - Baredes, S AU - Leeman, D J AU - Chen, T S AU - Mohit-Tabatabai, M A AD - Veterans Administration Medical Center, East Orange, NJ. PY - 1993 SP - 389 EP - 393 VL - 103 IS - 4 Pt 1 SN - 0023-852X, 0023-852X KW - Neoplasm Staging KW - Combined Modality Therapy KW - Lymphatic Metastasis KW - Human KW - Retrospective Studies KW - Aged KW - Palate, Soft KW - Neck KW - Survival Rate KW - Adult KW - Middle Age KW - Follow-Up Studies KW - Neoplasm Recurrence, Local KW - Lymph Node Excision KW - Carcinoma, Squamous Cell KW - Male KW - Palatal Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85196852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Significance+of+tumor+thickness+in+soft+palate+carcinoma.&rft.au=Baredes%2C+S%3BLeeman%2C+D+J%3BChen%2C+T+S%3BMohit-Tabatabai%2C+M+A&rft.aulast=Baredes&rft.aufirst=S&rft.date=1993-04-01&rft.volume=103&rft.issue=4+Pt+1&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Hypertension secondary to chlorpropamide with amelioration by changing to insulin. AN - 75809182; 8507452 AB - A retrospective analysis of the records of 22 type II diabetics whose treatment had been changed from insulin to chlorpropamide was performed to investigate the relative effects of insulin and chlorpropamide on blood pressure. Although diastolic BP index was not significantly different between the treatments, systolic BP index was significantly higher on chlorpropamide than on insulin (141 +/- 3 v 135 +/- 3 mm Hg, P = .02). In 10 patients in whom insulin was reinstituted, systolic BP fell significantly (P < .005), suggesting that in type II diabetics chlorpropamide exerts a relative hypertensive effect in comparison to insulin. JF - American journal of hypertension AU - Schmitt, J K AU - Moore, J R AD - Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 317 EP - 319 VL - 6 IS - 4 SN - 0895-7061, 0895-7061 KW - Insulin KW - 0 KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - Databases, Bibliographic KW - Blood Pressure KW - Blood Pressure Determination -- methods KW - Humans KW - Retrospective Studies KW - Middle Aged KW - Male KW - Female KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Chlorpropamide -- adverse effects KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Insulin -- therapeutic use KW - Chlorpropamide -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75809182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Hypertension+secondary+to+chlorpropamide+with+amelioration+by+changing+to+insulin.&rft.au=Schmitt%2C+J+K%3BMoore%2C+J+R&rft.aulast=Schmitt&rft.aufirst=J&rft.date=1993-04-01&rft.volume=6&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-14 N1 - Date created - 1993-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the efficacy and safety of ceftibuten and cefaclor in the treatment of pneumonia and bronchiectasis. AN - 75796463; 8515295 AB - In a multicentre, international study of 187 adult patients with bacterial pneumonia or bronchiectasis, the safety and efficacy of a regimen of 200 mg ceftibuten administered twice-daily was compared with cefaclor given in a dosage of 500 mg three times a day. Of the 94 evaluable patients, 66 received ceftibuten and 28 received cefaclor. The overall bacteriological response was similar in the two treatment groups with elimination of the original pathogen in 91% and 89% of the patients receiving ceftibuten and cefaclor, respectively. The overall clinical response mirrored the bacteriological results with a successful clinical outcome in 92% of ceftibuten-treated patients compared with 93% in patients receiving cefaclor. Adverse experiences were, in general, few and mild, being reported in 8% and 17% of patients receiving ceftibuten and cefaclor, respectively. JF - Journal of chemotherapy (Florence, Italy) AU - McCabe, R AU - Rumans, L AU - Perrotta, R AU - Mogabgab, W AD - Veterans Administration Medical Center, Martinez, CA 94553. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 124 EP - 132 VL - 5 IS - 2 SN - 1120-009X, 1120-009X KW - Cephalosporins KW - 0 KW - Cefaclor KW - 69K7K19H4L KW - ceftibuten KW - IW71N46B4Y KW - Index Medicus KW - Humans KW - Adult KW - Bacteria -- drug effects KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Pneumonia -- microbiology KW - Cefaclor -- therapeutic use KW - Cephalosporins -- therapeutic use KW - Pneumonia -- drug therapy KW - Cefaclor -- adverse effects KW - Bronchiectasis -- microbiology KW - Bacterial Infections -- drug therapy KW - Bronchiectasis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75796463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.atitle=Comparison+of+the+efficacy+and+safety+of+ceftibuten+and+cefaclor+in+the+treatment+of+pneumonia+and+bronchiectasis.&rft.au=McCabe%2C+R%3BRumans%2C+L%3BPerrotta%2C+R%3BMogabgab%2C+W&rft.aulast=McCabe&rft.aufirst=R&rft.date=1993-04-01&rft.volume=5&rft.issue=2&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.issn=1120009X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaesthetic properties of dimethylthiourea. AN - 75752418; 8499210 AB - We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. Dimethylthiourea 0.5 g kg-1 decreased isoflurane MAC by 23%; at a dose of 2.0-4.0 g kg-1, it abolished the response to tail clamp. Doses of 4.0 g kg-1 were lethal in the presence of isoflurane. A serum concentration of dimethylthiourea approximately 1 mg ml-1 produced a 50% reduction in isoflurane MAC. These anaesthetic properties of dimethylthiourea may influence experimental studies that examine the biochemical and physiological properties of this agent. JF - British journal of anaesthesia AU - Koblin, D D AU - Laster, M J AU - Liu, J AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 456 EP - 458 VL - 70 IS - 4 SN - 0007-0912, 0007-0912 KW - 1,3-dimethylthiourea KW - 8P30PMD17W KW - Isoflurane KW - CYS9AKD70P KW - Thiourea KW - GYV9AM2QAG KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Mice, Inbred ICR KW - Reflex -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Posture -- physiology KW - Drug Synergism KW - Male KW - Movement -- drug effects KW - Anesthesia, General KW - Thiourea -- analogs & derivatives KW - Thiourea -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75752418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+anaesthesia&rft.atitle=Anaesthetic+properties+of+dimethylthiourea.&rft.au=Koblin%2C+D+D%3BLaster%2C+M+J%3BLiu%2C+J&rft.aulast=Koblin&rft.aufirst=D&rft.date=1993-04-01&rft.volume=70&rft.issue=4&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=British+journal+of+anaesthesia&rft.issn=00070912&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-01 N1 - Date created - 1993-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Review article: lack of clinical significance of the interaction between H2-receptor antagonists and ethanol. AN - 75741359; 8097933 AB - It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2-receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2-antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2-antagonists and ethanol is clinically insignificant. JF - Alimentary pharmacology & therapeutics AU - Levitt, M D AD - Minneapolis Veterans Administration Medical Center, MN 55417. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 131 EP - 138 VL - 7 IS - 2 SN - 0269-2813, 0269-2813 KW - Histamine H2 Antagonists KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Drug Interactions KW - Humans KW - Gastric Mucosa -- metabolism KW - Histamine H2 Antagonists -- pharmacology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75741359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Review+article%3A+lack+of+clinical+significance+of+the+interaction+between+H2-receptor+antagonists+and+ethanol.&rft.au=Levitt%2C+M+D&rft.aulast=Levitt&rft.aufirst=M&rft.date=1993-04-01&rft.volume=7&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-09 N1 - Date created - 1993-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cholesterol exchange and lateral cholesterol pools in synaptosomal membranes of pair-fed control and chronic ethanol-treated mice. AN - 75719626; 8488977 AB - Most studies on effects of ethanol on membrane cholesterol have reported on changes in the total or bulk amount of cholesterol. Membrane cholesterol, however, can be described in terms of its kinetics and domains. The kinetics and size of lateral cholesterol exchangeable and nonexchangeable pools were examined in synaptosomes of pair-fed controls and chronic ethanol-treated mice. Effects of sphingomyelin, an exofacial leaflet phospholipid, that has been shown to affect cholesterol pools, were also examined. Radiolabeled small unilamellar vesicles were used to exchange cholesterol with synaptosomes. The total amounts of membrane cholesterol, phospholipid phosphorus, and the ratio of cholesterol to phospholipid did not differ between the pair-fed control and ethanol groups. In control mice, the rate constant (hr-1) and the t1/2 (hr) of cholesterol exchange were 0.065 +/- 0.001 and 10.7 +/- 0.25 (hr), respectively. The rate constant was significantly slower (0.053 +/- 0.001, p < 0.05) and the t1/2 significantly longer (13.33 +/- 0.58, p < 0.05) in synaptosomes of the ethanol group compared with the control group. The size of the exchangeable pool of cholesterol did not differ significantly between the two groups. Sphingomyelinase-induced hydrolysis of sphingomyelin significantly slowed cholesterol exchange with the largest effect in synaptosomes of the control group as compared with the ethanol group (p < 0.05). Hydrolysis of sphingomyelin had significantly (p < 0.05) less of an effect on cholesterol exchange in synaptosomes of the ethanol group. Membrane cholesterol can be described in terms of total content, transbilayer distribution, kinetics, and size of lateral pools.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Wood, W G AU - Rao, A M AU - Igbavboa, U AU - Semotuk, M AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 345 EP - 350 VL - 17 IS - 2 SN - 0145-6008, 0145-6008 KW - Phosphatidylcholines KW - 0 KW - Phosphatidylethanolamines KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Brain -- physiopathology KW - Animals KW - Phosphatidylethanolamines -- metabolism KW - Brain -- drug effects KW - Mice, Inbred C57BL KW - Phosphatidylcholines -- metabolism KW - Mice KW - Male KW - Synaptosomes -- drug effects KW - Cholesterol -- metabolism KW - Alcoholism -- physiopathology KW - Synaptic Membranes -- physiology KW - Synaptic Membranes -- drug effects KW - Synaptosomes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75719626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Cholesterol+exchange+and+lateral+cholesterol+pools+in+synaptosomal+membranes+of+pair-fed+control+and+chronic+ethanol-treated+mice.&rft.au=Wood%2C+W+G%3BRao%2C+A+M%3BIgbavboa%2C+U%3BSemotuk%2C+M&rft.aulast=Wood&rft.aufirst=W&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-08 N1 - Date created - 1993-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced inhibition of alveolar macrophage oxidant release in vivo and in vitro. AN - 75719089; 8387728 AB - Alcohol consumption is known to predispose the host to more frequent and severe bacterial infections, suggesting that alcohol compromises the normal immune function of the lung. The pulmonary alveolar macrophage is the resident host defense cell in the lung and forms the first line of defense against invading microorganisms. One of the mechanisms whereby alveolar macrophages kill bacteria is by releasing toxic oxygen radical species, such as superoxide anion and hydrogen peroxide. We hypothesized that chronic alcohol consumption caused alveolar macrophage dysfunction leading to inhibition of oxidant production when stimulated. Our data demonstrate that alveolar macrophages harvested from alcohol-treated rats release significantly lower quantity (p < 0.05) of both superoxide anion and hydrogen peroxide when stimulated with several different types of stimuli including heat-killed Staphylococcus aureus, soluble immune complexes or phorbol myristate acetate. Pair-fed control rats who received isocaloric quantities of maltose dextrin in their diet to compensate for the alcohol were able to produce oxidants in equal quantities when stimulated, to rats who were fed a normal diet. Similar results were noted in vitro experiments when alveolar macrophages harvested from normal rats were incubated in vitro in alcohol-containing media and then stimulated with the aforementioned stimuli. Alveolar macrophages, which had been incubated in alcohol for 4 hr, showed significant decreases in their ability to produce superoxide anion. This defect was noticeable for a period up to 8 hr following removal of alveolar macrophages from the alcohol-containing media.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Antony, V B AU - Godbey, S W AU - Hott, J W AU - Queener, S F AD - Department of Medicine, Veterans Administration Medical Center, Indianapolis, IN 46202. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 389 EP - 393 VL - 17 IS - 2 SN - 0145-6008, 0145-6008 KW - Superoxides KW - 11062-77-4 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Rats KW - Bronchoalveolar Lavage Fluid -- immunology KW - Animals KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Superoxides -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Alcoholism -- immunology KW - Macrophages, Alveolar -- drug effects KW - Macrophages, Alveolar -- immunology KW - Macrophage Activation -- immunology KW - Macrophage Activation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75719089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol-induced+inhibition+of+alveolar+macrophage+oxidant+release+in+vivo+and+in+vitro.&rft.au=Antony%2C+V+B%3BGodbey%2C+S+W%3BHott%2C+J+W%3BQueener%2C+S+F&rft.aulast=Antony&rft.aufirst=V&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-08 N1 - Date created - 1993-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos fiber type in malignant mesothelioma: an analytical scanning electron microscopic study of 94 cases. AN - 75709980; 8480769 AB - Although the association between asbestos exposure and malignant mesothelioma is indisputable, controversy continues regarding the relative contribution of the various types of asbestos fibers to the development of mesothelioma. We examined the types of asbestos fibers recovered from lung parenchyma in more than 90 cases of malignant mesothelioma from the United States, using an analytical scanning electron microscope. Almost half of the patients were former asbestos insulators or shipyard workers. The fibers were recovered from lung tissues obtained at autopsy or surgical resection by means of a sodium hypochlorite digestion procedure. Amosite asbestos was identified in 81% of the cases and accounted for 58% of all fibers 5 microns or greater in length. Tremolite/actinolite/anthophyllite were identified in 55% of the cases and accounted for 10% of all fiber types. Chrysotile was identified in 21% of the cases and accounted for 3% of fibers exceeding 5 microns in length. Crocidolite was found in 16% of the cases and accounted for 3% of fibers exceeding 5 microns in length. Nonasbestos mineral fibers (commonly found in the lungs of the general population) were observed in 71% of the cases and accounted for 25% of all fibers 5 microns or greater in length. The findings in this study are at odds with the assertion that crocidolite asbestos is responsible for most mesotheliomas in the United States. JF - American journal of industrial medicine AU - Roggli, V L AU - Pratt, P C AU - Brody, A R AD - Durham Veterans Administration, NC. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 605 EP - 614 VL - 23 IS - 4 SN - 0271-3586, 0271-3586 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Electron Probe Microanalysis KW - Aged, 80 and over KW - Humans KW - Lung -- chemistry KW - Adult KW - Lung -- ultrastructure KW - Aged KW - Middle Aged KW - Male KW - Female KW - Asbestos -- analysis KW - Lung Neoplasms -- chemistry KW - Mesothelioma -- pathology KW - Mesothelioma -- chemistry KW - Asbestos -- chemistry KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75709980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mechanism+of+gastric+hyperemia+induced+by+intragastric+hypertonic+saline+in+rats.&rft.au=Endoh%2C+K%3BKao%2C+J%3BDomek%2C+M+J%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-01-01&rft.volume=104&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-27 N1 - Date created - 1993-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 1994 Apr;25(4):609-10 [8010302] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. AN - 75709595; 8480854 AB - Catabolism of host hemoglobin by the malaria parasite liberates required amino acid precursors, but is also releases large amounts of potentially toxic heme that accumulates in parasite food vacuoles during intra-erythrocytic development. The schizonticidal drug chloroquine binds to free heme with high affinity and is concentrated in parasite food vacuoles. To better understand the disposition of heme within the host-parasite complex, we studied the balance of hemoglobin and heme in Plasmodium berghei-infected reticulocytes in the rat and compared this process in chloroquine-sensitive (CS) and chloroquine-resistant (CR) parasites. We found that CS P. berghei parasites have 1.5-fold more heme than CR parasites isolated from rats, and that CS P. berghei-infected reticulocytes accumulate more chloroquine than CR P. berghei-infected reticulocytes. Despite these differences in parasite heme content, the decrease in host cell hemoglobin content and the rate of free amino acid generation within the host-parasite complex is similar in CS and CR P. berghei-infected rat reticulocytes. The heme content of the infected reticulocyte-parasite complex decreases with increasing parasitemia but to a lesser extent than expected for the decrease in hemoglobin. Furthermore, the decrease in host-parasite heme is accelerated in the CR P. berghei infection compared with the CS P. berghei infection. Therefore, hemoglobin catabolism by malaria parasites is associated with the overall loss of heme from the host-parasite complex and with variable deposition of heme within parasites.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of tropical medicine and hygiene AU - Wood, P A AU - Eaton, J W AD - Stratton Veterans Administration Medical Center, Albany, New York. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 465 EP - 472 VL - 48 IS - 4 SN - 0002-9637, 0002-9637 KW - Hemoglobins KW - 0 KW - Heme KW - 42VZT0U6YR KW - Chloroquine KW - 886U3H6UFF KW - Abridged Index Medicus KW - Index Medicus KW - Reticulocytes -- chemistry KW - Rats KW - Erythrocytes -- parasitology KW - Erythrocytes -- chemistry KW - Animals KW - Rats, Sprague-Dawley KW - Analysis of Variance KW - Host-Parasite Interactions KW - Reticulocytes -- metabolism KW - Drug Resistance KW - Mice KW - Erythrocytes -- metabolism KW - Reticulocytes -- parasitology KW - Male KW - Hemoglobins -- analysis KW - Hemoglobins -- metabolism KW - Chloroquine -- pharmacology KW - Chloroquine -- metabolism KW - Malaria -- blood KW - Plasmodium berghei -- chemistry KW - Heme -- analysis KW - Plasmodium berghei -- metabolism KW - Malaria -- parasitology KW - Heme -- metabolism KW - Plasmodium berghei -- drug effects KW - Chloroquine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75709595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Hemoglobin+catabolism+and+host-parasite+heme+balance+in+chloroquine-sensitive+and+chloroquine-resistant+Plasmodium+berghei+infections.&rft.au=Wood%2C+P+A%3BEaton%2C+J+W&rft.aulast=Wood&rft.aufirst=P&rft.date=1993-04-01&rft.volume=48&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-26 N1 - Date created - 1993-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate. AN - 75708928; 8482320 AB - Cultured chick hepatocytes were used to investigate the hepatotoxicity of methotrexate alone and in combination with paracetamol. Treatment with methotrexate alone at concentrations as high as 1 mg/ml resulted in no toxicity in cultured chick hepatocytes, as indicated by no detachment of cells and no effect on protein synthesis or on release of the intracellular enzyme lactate dehydrogenase. However, treatment with methotrexate alone resulted in a 30% decrease in reduced glutathione levels. Combined treatment with methotrexate and paracetamol was toxic, but only in cells preinduced for cytochrome P450 1A by treatment with beta-naphthoflavone. Under these conditions, methotrexate lowered the threshold concentration of paracetamol at which toxicity was observed. This methotrexate-mediated increase in paracetamol toxicity was associated with decreased formation of the glucuronide, sulfate and thiol metabolites of paracetamol and with increased covalent binding of radiolabeled paracetamol to macromolecules. In cells pretreated with beta-naphthoflavone, additional treatment with either methotrexate or buthionine sulfoximine, an inhibitor of glutathione synthesis, together with paracetamol, was associated with decreased restoration of glutathione levels. These results suggest that methotrexate increased paracetamol toxicity by decreasing the amount of glutathione available for conjugation with reactive metabolites of paracetamol. JF - European journal of pharmacology AU - Lindenthal, J AU - Sinclair, J F AU - Howell, S AU - Cargill, I AU - Sinclair, P R AU - Taylor, T AD - Veterans Administration Center, White River Junction, VT 05009. Y1 - 1993/04/01/ PY - 1993 DA - 1993 Apr 01 SP - 289 EP - 298 VL - 228 IS - 5-6 SN - 0014-2999, 0014-2999 KW - Benzoflavones KW - 0 KW - Methionine Sulfoximine KW - 1982-67-8 KW - Acetaminophen KW - 362O9ITL9D KW - Buthionine Sulfoximine KW - 5072-26-4 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Glutathione KW - GAN16C9B8O KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Glutathione -- metabolism KW - Chick Embryo KW - Enzyme Induction -- physiology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Methionine Sulfoximine -- pharmacology KW - Methionine Sulfoximine -- analogs & derivatives KW - Drug Synergism KW - Benzoflavones -- pharmacology KW - Liver -- cytology KW - Liver -- drug effects KW - Liver -- metabolism KW - Acetaminophen -- metabolism KW - Methotrexate -- toxicity KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75708928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Toxicity+of+paracetamol+in+cultured+chick+hepatocytes+treated+with+methotrexate.&rft.au=Lindenthal%2C+J%3BSinclair%2C+J+F%3BHowell%2C+S%3BCargill%2C+I%3BSinclair%2C+P+R%3BTaylor%2C+T&rft.aulast=Lindenthal&rft.aufirst=J&rft.date=1993-04-01&rft.volume=228&rft.issue=5-6&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-28 N1 - Date created - 1993-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of alpha 2-adrenoceptors in mechanism of intragastric nicotine protection against ethanol injury in rat stomach. AN - 75676501; 8096456 AB - To elucidate the role of alpha- and beta-adrenoceptors in the mechanism of intragastric nicotine protection against ethanol-induced gastric mucosal injury, the following studies were performed. At 0.5-hr prior to the injury study, rats were pretreated with: subcutaneous control, prazosin (0.5 mg/kg) or yohimbine (5 mg/kg) to block alpha 1- or alpha 2-adrenoceptors; or intraperitoneal control, metoprolol (2 mg/kg) or butoxamine (4 mg/kg) to block beta 1- or beta 2-adrenoceptors, respectively. At 1-hr intervals, rats received intragastric vehicle or nicotine (4 mg/kg) and 40% ethanol (10 ml/kg). Total lengths of the linear gastric corpus mucosal lesions were measured by an unbiased observer using a caliper. In a separate study, 0.5-hr after subcutaneous control or yohimbine (5 mg/kg), rats were treated with intragastric vehicle or nicotine (4 mg/kg). One hour later, gastric mucus volume, gastric juice volume and pH, and titratable acid in the gastric juice were measured. In the rat stomach, the intragastric nicotine protection against 40% ethanol-induced mucosal injury was not blocked by selective alpha 1-(prazosin), beta 1-(metoprolol), or beta 2-(butoxamine) adrenoceptor antagonists. The protection was significantly reduced although not completely abolished by selective alpha 2-(yohimbine) adrenoceptor antagonist. Yohimbine also significantly reduced basal and nicotine-stimulated increase in gastric mucus volume. These data suggest that alpha 2-adrenoceptors are involved in the protective effect of intragastric nicotine against 40% ethanol-induced gastric mucosal injury possibly by a mucus-dependent mechanism. JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 713 EP - 721 VL - 38 IS - 4 SN - 0163-2116, 0163-2116 KW - Adrenergic alpha-Antagonists KW - 0 KW - Adrenergic beta-Antagonists KW - Receptors, Adrenergic, alpha KW - Receptors, Adrenergic, beta KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Receptors, Adrenergic, beta -- drug effects KW - Gastric Juice -- drug effects KW - Blood Pressure -- drug effects KW - Drug Evaluation, Preclinical KW - Adrenergic beta-Antagonists -- pharmacology KW - Male KW - Adrenergic alpha-Antagonists -- pharmacology KW - Ethanol -- administration & dosage KW - Receptors, Adrenergic, alpha -- drug effects KW - Nicotine -- administration & dosage KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75676501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Involvement+of+alpha+2-adrenoceptors+in+mechanism+of+intragastric+nicotine+protection+against+ethanol+injury+in+rat+stomach.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-04-01&rft.volume=38&rft.issue=4&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-05 N1 - Date created - 1993-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of intragastric tetramethylammonium protection against 40% ethanol injury in rat stomach. AN - 75657658; 8462370 AB - The effect of tetramethylammonium (TMA), a ganglionic stimulant, on gastric mucosal injury induced by 40% ethanol was examined. In studies I-III, rats were treated with intragastric vehicle or TMA (1 or 10 mg/kg). In study I, 1 hr after the treatment, 40% ethanol was given intragastrically. The length of the linear corpus mucosal lesions was measured unbiasedly with a caliper after another hour. In study II, mean blood pressure was assessed before and after the treatment. In study III, 1 hr after the treatment, gastric mucus and juice volumes, and titratable acid were measured. In study IV, 40% ethanol (10 ml/kg) was administered intragastrically immediately after 0.2 or 1.4 ml of intragastric vehicle treatment. One hour later, gastric lesions score was assessed as in study I. Results show that (1) intragastric TMA dose-dependently protected against 40% ethanol-induced gastric injury; (2) neither dose of intragastric TMA increased mean blood pressure; (3) there was a dose-related increase in gastric mucus secretion for TMA 1 and 10 mg/kg, and a significant increase in gastric juice volume only for TMA 10 mg/kg; and (4) the rats treated with 1.4 ml of vehicle plus 40% ethanol had significantly less injury than those treated with 0.2 ml of vehicle plus 40% ethanol. We conclude that the protective effect of intragastric TMA can be explained by its dose-related effect in enhancing gastric mucus secretion for TMA 1 and 10 mg/kg and the significantly greater increase in gastric juice volume for TMA 10 mg/kg.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Scremin, O U AU - Leung, F W AD - Research and Medical Services, Sepulveda, Veterans Administration Medical Center, California 91343. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 708 EP - 712 VL - 38 IS - 4 SN - 0163-2116, 0163-2116 KW - Ganglionic Stimulants KW - 0 KW - Quaternary Ammonium Compounds KW - Ethanol KW - 3K9958V90M KW - tetramethylammonium KW - H0W55235FC KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Gastric Juice -- drug effects KW - Blood Pressure -- drug effects KW - Drug Evaluation, Preclinical KW - Male KW - Quaternary Ammonium Compounds -- administration & dosage KW - Ethanol -- administration & dosage KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Ganglionic Stimulants -- administration & dosage KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75657658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Mechanism+of+intragastric+tetramethylammonium+protection+against+40%25+ethanol+injury+in+rat+stomach.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BScremin%2C+O+U%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-04-01&rft.volume=38&rft.issue=4&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-05 N1 - Date created - 1993-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate. AN - 75723262; 8387623 AB - Primary and first-passage dog urothelial cells (DUC and DUC-P1, respectively) exhibited an active catalytic subunit for the cyclic adenosine monophosphate (cAMP) second messenger system. Dramatic increases in cAMP levels were observed following the addition of forskolin, which elicited a time- and dose-response--dependent increase in cAMP levels. Increases in intracellular cAMP levels preceded media increases in cyclic nucleotide levels and were observed at the earliest time examined (5 minutes). The lowest effective concentration of forskolin was between 1 and 10 mumol/L. cAMP level increases as large as 20- to 100-fold were observed in cells and media. Preincubation of primary and subcultured cells with 0.1 mumol/L 12-O-tetradecanoylphorbol-13-acetate (TPA) for 60 minutes reduced the magnitude of the forskolin-induced increase in cAMP levels. To determine the mechanism by which TPA elicits its effect in primary cultures, the following test agents were used: 1.0 mumol/L staurosporine and 25 mumol/L sphingosine, protein kinase C inhibitors; 35 mumol/L cycloheximide, a protein synthesis inhibitor; 3.0 mumol/L indomethacin, an inhibitor of prostaglandin synthesis; and 0.5 mmol/L RO-20-1724, a cyclic nucleotide phosphodiesterase inhibitor. Staurosporine and sphingosine were the only agents that prevented the effect of TPA. The specificity of the TPA effect was evaluated with the following test agents: 0.2 nmol/L epidermal growth factor (EGF), 0.1 mumol/L 4 alpha-TPA (a stereoisomer of TPA), or 1.0 mumol/L A23187. In contrast to TPA, none of these agents reduced forskolin-mediated increases in cAMP. Results indicate forskolin cAMP responsiveness and regulation of this response by TPA in both primary and subcultured cells.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Metabolism: clinical and experimental AU - Thomas, D J AU - Zenser, T V AU - Davis, B B AD - Veterans Administration Medical Center, St Louis, MO 63125. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 297 EP - 302 VL - 42 IS - 3 SN - 0026-0495, 0026-0495 KW - Alkaloids KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone KW - 29925-17-5 KW - Calcimycin KW - 37H9VM9WZL KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cycloheximide KW - 98600C0908 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Staurosporine KW - H88EPA0A3N KW - Sphingosine KW - NGZ37HRE42 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Calcimycin -- pharmacology KW - Epidermal Growth Factor -- pharmacology KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone -- pharmacology KW - Models, Biological KW - Indomethacin -- pharmacology KW - Signal Transduction -- physiology KW - Protein Kinase C -- antagonists & inhibitors KW - Colforsin -- pharmacology KW - Second Messenger Systems -- physiology KW - Epithelial Cells KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Epithelium -- physiology KW - Dogs KW - Alkaloids -- pharmacology KW - Sphingosine -- pharmacology KW - Epithelium -- metabolism KW - Urinary Bladder -- metabolism KW - Urinary Bladder -- physiology KW - Cyclic AMP -- antagonists & inhibitors KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Urinary Bladder -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75723262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Cyclic+adenosine+monophosphate+response+in+primary+and+subcultured+bladder+epithelial+cells%3A+inhibition+by+12-O-tetradecanoylphorbol-13-acetate.&rft.au=Thomas%2C+D+J%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Thomas&rft.aufirst=D&rft.date=1993-03-01&rft.volume=42&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-04 N1 - Date created - 1993-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of retroviral infections on immune function in African-American intravenous drug users. AN - 75678338; 8471194 AB - To determine the effect of retrovirus infection and co-infection, and intravenous substance use, on immune function in African-Americans. A cohort of South Florida street-recruited African-American intravenous drug users formed the study population. The cohort consisted of 90 HIV-negative & human T-lymphotropic virus (HTLV)-negative, one HIV-negative & HTLV-I-positive, 11 HIV-negative & HTLV-II-positive, 79 HIV-positive & HTLV-negative, one HIV-positive & HTLV-I-positive and 21 HIV-positive & HTLV-II-positive individuals. The results reported are for the cross-sectional, baseline assessment of immune parameters. Lymphocyte phenotypic distributions and functional markers, including proliferative response to mitogens and natural killer cell cytotoxicity, were determined. Serum immunoglobulin (Ig) levels were determined as a measure of B-cell activity. HTLV-II infection was associated with increases in CD8 lymphocyte count and serum Ig, but with no other significant immunologic changes. The distribution of CD4 and CD8 percentages, CD4:CD8 ratio, phytohemagglutinin (PHA) and pokeweed mitogen (PWM) reactivity, IgA and IgG for the four retrovirus serostatus groups suggested the possibility of interactive effects in the co-infected group, as demonstrated by a trend toward lower medians for CD4 and for PHA and PWM response and higher medians for IgG, IgA and CD8. Retrovirus-seronegative intravenous drug users had significantly impaired immune status compared with non-drug-using control individuals. Immunologic dysfunction attributable to HTLV-II infection was minor compared with HIV infection in this population. Study subjects who were co-infected with HIV and HTLV demonstrated more impairment of immune function than individuals with single retrovirus infections. JF - AIDS (London, England) AU - Klimas, N G AU - Page, J B AU - Patarca, R AU - Chitwood, D AU - Morgan, R AU - Fletcher, M A AD - Miami Veterans Administration Medical Center, Florida. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 331 EP - 335 VL - 7 IS - 3 SN - 0269-9370, 0269-9370 KW - Immunoglobulins KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Lymphocyte Activation KW - Immunoglobulins -- analysis KW - Humans KW - Cohort Studies KW - Adult KW - CD4-CD8 Ratio KW - Immunophenotyping KW - African Continental Ancestry Group KW - Male KW - Female KW - HTLV-II Infections -- immunology KW - HIV Infections -- complications KW - HIV Infections -- immunology KW - African Americans KW - HTLV-II Infections -- complications KW - Substance Abuse, Intravenous -- immunology KW - Substance Abuse, Intravenous -- complications KW - HTLV-I Infections -- immunology KW - HTLV-I Infections -- complications KW - HIV-1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75678338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Effects+of+retroviral+infections+on+immune+function+in+African-American+intravenous+drug+users.&rft.au=Klimas%2C+N+G%3BPage%2C+J+B%3BPatarca%2C+R%3BChitwood%2C+D%3BMorgan%2C+R%3BFletcher%2C+M+A&rft.aulast=Klimas&rft.aufirst=N&rft.date=1993-03-01&rft.volume=7&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-17 N1 - Date created - 1993-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative cost-effectiveness analysis of theophylline and ipratropium bromide in chronic obstructive pulmonary disease. A three-center study. AN - 75618872; 8449051 AB - The charts of 311 patients receiving theophylline (T) and 289 patients receiving ipratropium bromide (IB) for COPD were reviewed to determine the total costs and cost-effectiveness of these 2 agents in 3 different health-care settings. A direct cost-accounting method assessed cost, and a Markov decision-analysis model calculated cost-effectiveness. Costs to treat toxic effects were greater for T versus IB. The types and incidences of toxic effects, by drug, were similar among the three centers. Overall costs for T were $121.40 per patient per therapy-month versus $84.56 per patient per therapy-month for IB, as determined by the cost-accounting method. The marginal cost was $366 for T over IB when extrapolated over 1 year using the Markov model. The Markov model also predicted that patients receiving IB had a greater number of complication-free therapy-months (measurement of effectiveness) than patients receiving T. We conclude that treatment with IB was less costly and more cost-effective than T. JF - Chest AU - Jubran, A AU - Gross, N AU - Ramsdell, J AU - Simonian, R AU - Schuttenhelm, K AU - Sax, M AU - Kaniecki, D J AU - Arnold, R J AU - Sonnenberg, F A AD - Division of Pulmonary and Critical Care Medicine, Edward Hines Jr. Veterans Administration Hospital, Hines, IL. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 678 EP - 684 VL - 103 IS - 3 SN - 0012-3692, 0012-3692 KW - Theophylline KW - C137DTR5RG KW - Ipratropium KW - GR88G0I6UL KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Health Maintenance Organizations -- statistics & numerical data KW - Analysis of Variance KW - Hospitals, University -- statistics & numerical data KW - Illinois KW - Humans KW - Chi-Square Distribution KW - Hospitalization -- economics KW - Aged KW - Hospitals, Veterans -- statistics & numerical data KW - Hospitals, Veterans -- economics KW - California KW - Hospitals, University -- economics KW - Health Maintenance Organizations -- economics KW - Treatment Outcome KW - Middle Aged KW - Markov Chains KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - Ipratropium -- adverse effects KW - Theophylline -- adverse effects KW - Cost of Illness KW - Theophylline -- economics KW - Ipratropium -- economics KW - Cost-Benefit Analysis -- statistics & numerical data KW - Lung Diseases, Obstructive -- epidemiology KW - Lung Diseases, Obstructive -- economics KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75618872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Comparative+cost-effectiveness+analysis+of+theophylline+and+ipratropium+bromide+in+chronic+obstructive+pulmonary+disease.+A+three-center+study.&rft.au=Jubran%2C+A%3BGross%2C+N%3BRamsdell%2C+J%3BSimonian%2C+R%3BSchuttenhelm%2C+K%3BSax%2C+M%3BKaniecki%2C+D+J%3BArnold%2C+R+J%3BSonnenberg%2C+F+A&rft.aulast=Jubran&rft.aufirst=A&rft.date=1993-03-01&rft.volume=103&rft.issue=3&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-09 N1 - Date created - 1993-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine Treatment at the Drug Dependency Program of the Minneapolis VA Medical Center: A Program Director's Perspective AN - 61630970; 199301970 AB - The integration of nicotine addiction treatment with inpatient chemical dependency treatment, as practiced at the Drug Dependency Treatment program of the Minneapolis (Minn) Veterans Administration Medical Canter, is explored through follow-up interviews with 106 patients. Nicotine recovery was incorporated into all educational & therapeutic activities as well as traditional recovery tools. It was found that 6 weeks after discharge, 58% of patients who were smokers at admission were nicotine-free or had greatly reduced use, & 98% of these were abstinent from drugs & alcohol. 8 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Pletcher, Vincent C AD - Drug Dependency Treatment Program Veterans Administration Medical Center, One Veterans Dr Minneapolis MN 55417 Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 139 EP - 145 VL - 10 IS - 2 SN - 0740-5472, 0740-5472 KW - chemical dependency-nicotine addiction treatment integration, Minneapolis (Minnesota) Veterans Administration Medical Center KW - case study KW - Veterans KW - Smoking KW - Minneapolis, Minnesota KW - Drug Addiction KW - Government Agencies KW - Treatment Methods KW - Hospitals KW - article KW - 6129: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61630970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Nicotine+Treatment+at+the+Drug+Dependency+Program+of+the+Minneapolis+VA+Medical+Center%3A+A+Program+Director%27s+Perspective&rft.au=Pletcher%2C+Vincent+C&rft.aulast=Pletcher&rft.aufirst=Vincent&rft.date=1993-03-01&rft.volume=10&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Minneapolis, Minnesota; Smoking; Veterans; Government Agencies; Hospitals; Treatment Methods; Drug Addiction ER - TY - JOUR T1 - Usefulness of a Discharge Diagnosis of Sepsis in Detecting Iatrogenic Infection and Quality of Care Problems AN - 21015627; 10091610 AB - To address the question of how often a diagnosis of sepsis in the discharge summary represents a condi tion present on hospital admission as opposed to an acquired condition, medical records from Veterans Affairs medical centers were reviewed. A random sample of discharged summaries coded for sepsis were obtained from five different hospitals. One hundred forty-one summaries involving 128 patients from 1989 were evaluated. Twenty-seven (18.7%) of the summaries were judged to be improperly coded. Of the remaining 114 summaries, 61 (53.5%) contained information supporting sepsis as an admission con dition. Comparison of other clinical attributes of these summaries indicates that patients with sepsis on ad mission have some characteristics that are different from those of patients who acquire sepsis during care. These attributes include a history of chemotherapy, an overall shorter length of stay, and a lower death rate. Sepsis, as a discharge diagnosis, cannot be as sumed to represent an iatrogenic condition or to be the result of poor care since more than half of the cases reviewed indicated that the condition was pres ent at admission. JF - Quality Assurance and Utilization Review (United States) AU - Barbour, Galen L AD - Veterans Health Administration, Department of Veterans Affairs, Washington, D.C Y1 - 1993/03// PY - 1993 DA - Mar 1993 SP - 2 EP - 5 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 8 IS - 1 SN - 0885-713X, 0885-713X KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - medical records KW - Chemotherapy KW - Quality control KW - Iatrogenic infection KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21015627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Cationic+protein+from+a+urate-calcium+oxalate+stone%3A+isolation+and+purification+of+a+shared+protein&rft.au=Binette%2C+J+P%3BBinette%2C+M+B&rft.aulast=Binette&rft.aufirst=J&rft.date=1993-01-01&rft.volume=7&rft.issue=3&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sepsis; medical records; Quality control; Chemotherapy; Iatrogenic infection; Hospitals DO - http://dx.doi.org/10.1177/0885713x9300800102 ER - TY - JOUR T1 - Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats. AN - 75638034; 8095837 AB - The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N-methyl-D-aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and that the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity. JF - Brain research AU - Finnegan, K T AU - Calder, L AU - Clikeman, J AU - Wei, S AU - Karler, R AD - Psychiatry Service, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1993/02/12/ PY - 1993 DA - 1993 Feb 12 SP - 134 EP - 138 VL - 603 IS - 1 SN - 0006-8993, 0006-8993 KW - Calcium Channel Blockers KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Verapamil KW - CJ0O37KU29 KW - Nifedipine KW - I9ZF7L6G2L KW - Haloperidol KW - J6292F8L3D KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Flunarizine KW - R7PLA2DM0J KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Brain Chemistry -- drug effects KW - Hippocampus -- metabolism KW - Stereotyped Behavior -- drug effects KW - Seizures -- prevention & control KW - Verapamil -- pharmacology KW - Methamphetamine -- antagonists & inhibitors KW - Hippocampus -- drug effects KW - Rats KW - Nifedipine -- pharmacology KW - Rats, Sprague-Dawley KW - Haloperidol -- pharmacology KW - Methamphetamine -- pharmacology KW - Flunarizine -- pharmacology KW - Male KW - Calcium Channel Blockers -- pharmacology KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - 3,4-Methylenedioxyamphetamine -- pharmacology KW - Serotonin -- metabolism KW - 3,4-Methylenedioxyamphetamine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75638034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Effects+of+L-type+calcium+channel+antagonists+on+the+serotonin-depleting+actions+of+MDMA+in+rats.&rft.au=Finnegan%2C+K+T%3BCalder%2C+L%3BClikeman%2C+J%3BWei%2C+S%3BKarler%2C+R&rft.aulast=Finnegan&rft.aufirst=K&rft.date=1993-02-12&rft.volume=603&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-16 N1 - Date created - 1993-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Processing in the Neglected Visual Field: Evidence from a Lexical Decision Task AN - 85555364; 9305314 AB - An examination of the extent to which a dissociation between visual information processing & conscious awareness of that processing exists in patients with unilateral visual neglect. Patients with left-sided visual neglect & with a dense left visual field hemianopia with no neglect (N = 4 & 1, respectively) were compared to a control group of Ss (N = 10) with no history of neurological damage or disease. An implicit semantic priming task in which patients made lexical decisions to a centrally located letter string, preceded by a laterally presented picture prime. Findings indicate that patients with unilateral, left visual neglect can extract semantic information implicitly from the same visual stimuli presented to the left or to the right visual field. However, a patient with a dense left hemianopia without neglect failed to show priming from the affected field. A second experiment employed the same stimuli & presentation conditions but required an explicit awareness of visual stimuli. As expected, the performance of neglect patients, & a hemianopic patient, was at chance in the left visual field. The semantic priming effects reported here are difficult to reconcile with any theory of neglect that postulates that information is filtered out early in the course of visual processing. Rather, the current findings indicate that the pathways critical for the formation of visual representations are at most only partially disrupted. Alternatively, neglect may also be seen as a disorder in accessing these representations intentionally. 1 Table, 2 Figures, 53 References. Adapted from the source document JF - Cognitive Neuropsychology AU - McGlinchey-Berroth, Regina AU - Milberg, William P AU - Verfaellie, Mieke AU - Alexander, Michael AU - Kilduff, Patrick T AD - Geriatric Research/Education/Clinical Centre Veterans Administration Medical Centre, 1400 V.F.W. Parkway West Roxbury MA 02132 Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 79 EP - 108 VL - 10 IS - 1 SN - 0264-3294, 0264-3294 KW - unilateral visual neglect, visual information processing/conscious awareness dissociation extent KW - semantic priming tasks KW - left-sided visual neglect/hemianopia-no neglect patients/normal controls KW - Visual Stimulation (94700) KW - Lexical Semantics (46770) KW - Vision Disorders (94350) KW - Information Processing (35900) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85555364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognitive+Neuropsychology&rft.atitle=Semantic+Processing+in+the+Neglected+Visual+Field%3A+Evidence+from+a+Lexical+Decision+Task&rft.au=McGlinchey-Berroth%2C+Regina%3BMilberg%2C+William+P%3BVerfaellie%2C+Mieke%3BAlexander%2C+Michael%3BKilduff%2C+Patrick+T&rft.aulast=McGlinchey-Berroth&rft.aufirst=Regina&rft.date=1993-02-01&rft.volume=10&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Cognitive+Neuropsychology&rft.issn=02643294&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - COGNEP N1 - SubjectsTermNotLitGenreText - Vision Disorders (94350); Lexical Semantics (46770); Visual Stimulation (94700); Information Processing (35900) ER - TY - JOUR T1 - Comparison of dideoxynucleoside drugs (DDI and zidovudine) and induction of hematopoietic toxicity using normal human bone marrow cells in vitro. AN - 75672670; 8468123 AB - The drug zidovudine (AZT), a synthetic thymidine analog, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of zidovudine has induced hematopoietic toxicity manifested by anemia, neutropenia and on occasion thrombocytopenia. Such toxicity has stimulated the development of alternative dideoxynucleoside drugs capable of exerting anti-viral potency while minimizing the risk for inducing organ toxicities. One such alternative dideoxynucleoside drug is 2',3'-dideoxyinosine (ddI). Recent therapeutic anti-viral strategy, now undergoing clinical trial, is the evaluation of combined zidovudine ddI treatment. Unfortunately a complete assessment of their potential toxicity using this drug regimen has not been thoroughly examined. We report here the results of studies comparing the toxicity profile of zidovudine versus ddI on their ability to influence several classes of hematopoietic progenitor stem cells, e.g. granulocyte--macrophage (CFU-GM), megakaryocyte (CFU-Meg) and erythroid (CFU-E/BFU-E) following in vitro co-culture with normal human bone marrow. Since the main clinical toxicity associated with zidovudine in vivo is the development of anemia, additional in vitro studies compared the dose-escalation effect of erythropoietin in the presence of combined zidovudine and ddI. CFU-GM, CFU-Meg, CFU-E and BFU-E were all reduced (P < 0.05) following incubation with either zidovudine or ddI thus determining their ID50 concentrations for these classes of hematopoietic progenitors; however, the extent of toxicity associated with ddI was lower than what was observed with zidovudine. More importantly, dose-escalation of erythropoietin was effective in reversing the inhibition observed for ddI on erythroid progenitors CFU-E and BFU-E (P < 0.05), an effect not reported with zidovudine in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) JF - International journal of immunopharmacology AU - Gallicchio, V S AU - Hughes, N K AU - Tse, K F AD - Department of Veterans Affairs, Veterans Administration Medical Center, Lexington, Kentucky. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 263 EP - 268 VL - 15 IS - 2 SN - 0192-0561, 0192-0561 KW - Erythropoietin KW - 11096-26-7 KW - Zidovudine KW - 4B9XT59T7S KW - Didanosine KW - K3GDH6OH08 KW - Index Medicus KW - AIDS/HIV KW - Bone Marrow Cells KW - Drug Interactions KW - Hematopoiesis -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Erythropoietin -- administration & dosage KW - In Vitro Techniques KW - Hematopoietic Stem Cells -- cytology KW - Colony-Forming Units Assay KW - Hematopoietic Stem Cells -- drug effects KW - Zidovudine -- adverse effects KW - Didanosine -- administration & dosage KW - Zidovudine -- administration & dosage KW - Bone Marrow -- drug effects KW - Didanosine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75672670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Comparison+of+dideoxynucleoside+drugs+%28DDI+and+zidovudine%29+and+induction+of+hematopoietic+toxicity+using+normal+human+bone+marrow+cells+in+vitro.&rft.au=Gallicchio%2C+V+S%3BHughes%2C+N+K%3BTse%2C+K+F&rft.aulast=Gallicchio&rft.aufirst=V&rft.date=1993-02-01&rft.volume=15&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-12 N1 - Date created - 1993-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiproliferative effects of interferons -alpha and -beta in combination with 5-fluorouracil, cisplatin, and cis- and trans-retinoic acid in three human lung carcinoma cell lines. AN - 75649730; 8384234 AB - We assessed the antiproliferative effect of human recombinant interferon -alpha (IFN-alpha) or -beta in combination with 5-fluorouracil (5-FU), cisplatin, or cis- or trans-retinoic acid on two human nonsmall cell lung carcinoma cell lines (SK-LU-1 and SK-MES-1) and on one human small cell lung carcinoma cell line (NCI-H69). Results were obtained by direct cell count and/or by the clonigenic assay. The three cell lines differed in their sensitivities to the antiproliferative effects of the different agents. However, both NSCLC cell lines were more responsive to IFN-beta than to IFN-alpha. The SK-MES cell line was more resistant to both IFNs than the SK-LU-1. The NCI-H69 cells were resistant to all the drugs tested, except trans-retinoic acid. The dose and time of exposure were found to be important factors in the case of IFNs and cytotoxic agents, with lower surviving fractions obtained with the higher doses and longer exposures. This finding, however, did not hold true for the retinoic acids, which showed no antiproliferative effect. Within the sensitivity of our system, we did not identify any synergistic interaction in any of the cell lines with IFN-alpha or IFN-beta and 5-FU or cisplatin. A slight synergistic interaction was observed with IFN and cis- or trans-retinoic acid in the SK-LU-1 cell line which was not thought to be clinically significant.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of interferon research AU - Arbaje, Y M AU - Bittner, G AU - Yingling, J M AU - Storer, B AU - Schiller, J H AD - Section of Oncology, William S. Middleton Memorial Veterans Administration Hospital, Madison, WI. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 25 EP - 32 VL - 13 IS - 1 SN - 0197-8357, 0197-8357 KW - Interferon Type I KW - 0 KW - Recombinant Proteins KW - Tretinoin KW - 5688UTC01R KW - Interferon-beta KW - 77238-31-4 KW - Isotretinoin KW - EH28UP18IF KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Isotretinoin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Interferon-beta -- administration & dosage KW - Interferon Type I -- administration & dosage KW - Tumor Cells, Cultured KW - Humans KW - Tretinoin -- administration & dosage KW - Cell Division -- drug effects KW - Drug Synergism KW - Recombinant Proteins -- administration & dosage KW - Cisplatin -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75649730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+research&rft.atitle=Antiproliferative+effects+of+interferons+-alpha+and+-beta+in+combination+with+5-fluorouracil%2C+cisplatin%2C+and+cis-+and+trans-retinoic+acid+in+three+human+lung+carcinoma+cell+lines.&rft.au=Arbaje%2C+Y+M%3BBittner%2C+G%3BYingling%2C+J+M%3BStorer%2C+B%3BSchiller%2C+J+H&rft.aulast=Arbaje&rft.aufirst=Y&rft.date=1993-02-01&rft.volume=13&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-19 N1 - Date created - 1993-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of chronic ethanol on the septohippocampal system: a role for neurotrophic factors? AN - 75639822; 8452192 AB - The mechanisms by which chronic ethanol exposure produces neuronal damage have not been established. Potentially ethanol may reduce normal neurotrophic influences necessary for neuronal survival, growth, and function. We hypothesized that chronic ethanol exposure might produce a decrease in the synthesis, availability, upregulation, delivery, and/or the biological activity of normally occurring neurotrophic factors, or may alter the capacity of target neurons to respond to these factors. The available evidence leading to this hypothesis and supporting data from our laboratory are discussed. JF - Alcoholism, clinical and experimental research AU - Walker, D W AU - Heaton, M B AU - Lee, N AU - King, M A AU - Hunter, B E AD - Gainesville Veterans Administration Medical Center, Florida. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 12 EP - 18 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Nerve Growth Factors KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neurons -- physiology KW - Nerve Regeneration -- physiology KW - Brain Damage, Chronic -- physiopathology KW - Septum Pellucidum -- physiopathology KW - Hippocampus -- physiopathology KW - Nerve Growth Factors -- physiology KW - Alcoholism -- physiopathology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75639822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effect+of+chronic+ethanol+on+the+septohippocampal+system%3A+a+role+for+neurotrophic+factors%3F&rft.au=Walker%2C+D+W%3BHeaton%2C+M+B%3BLee%2C+N%3BKing%2C+M+A%3BHunter%2C+B+E&rft.aulast=Walker&rft.aufirst=D&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amethystic agents and adjunct behavioral therapy and psychotherapy. AN - 75629523; 8452203 JF - Alcoholism, clinical and experimental research AU - Gallant, D AD - Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 197 EP - 198 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Cyanamide KW - 420-04-2 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Combined Modality Therapy KW - Substance Abuse Detection KW - Humans KW - Outcome and Process Assessment (Health Care) KW - Alcoholism -- rehabilitation KW - Psychotherapy KW - Cognitive Therapy KW - Cyanamide -- therapeutic use KW - Alcoholism -- psychology KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75629523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Amethystic+agents+and+adjunct+behavioral+therapy+and+psychotherapy.&rft.au=Gallant%2C+D&rft.aulast=Gallant&rft.aufirst=D&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling". AN - 75625637; 8452212 AB - Prior experience with ethanol (EtOH) withdrawal may sensitize an individual to subsequent withdrawal episodes. It has been hypothesized that the progressive intensification of the EtOH withdrawal syndrome following repeated episodes of EtOH intoxication and withdrawal may represent the manifestations of a "kindling" mechanism. The purpose of this study was to develop an animal model of EtOH withdrawal that is sensitive to the effects of prior withdrawal experience. Adult male C3H mice were chronically exposed to EtOH vapor in inhalation chambers prior to withdrawal testing. A multiple withdrawal (MW) group received 3 cycles of 16 hr EtOH vapor separated by 8-hr periods of abstinence; a single withdrawal (SW) group received a single bout of EtOH exposure (16 hr); a third group (SW-CONT) experienced a single withdrawal episode after receiving the equivalent amount of EtOH intoxication as the MW group (16 x 3 = 48 hr), but in a continuous (uninterrupted) fashion; and a fourth group (C) served as controls, not receiving any EtOH exposure throughout the study. Severity of the withdrawal response was assessed by scoring handling-induced convulsions hourly for the first 10 hr and then at 24 hr postwithdrawal. The results indicated that the severity of EtOH withdrawal seizures was significantly greater in animals that had a prior history of withdrawal episodes (MW group) in comparison to a separate group of animals that were tested following a single withdrawal from the same 16-hr intoxication period (SW group).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Becker, H C AU - Hale, R L AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 94 EP - 98 VL - 17 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Handling (Psychology) KW - Brain -- physiopathology KW - Animals KW - Alcoholic Intoxication -- physiopathology KW - Body Temperature Regulation -- physiology KW - Mice, Inbred C3H KW - Body Weight -- physiology KW - Disease Models, Animal KW - Mice KW - Alcoholism -- physiopathology KW - Male KW - Seizures -- physiopathology KW - Alcohol Withdrawal Delirium -- physiopathology KW - Kindling, Neurologic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75625637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Repeated+episodes+of+ethanol+withdrawal+potentiate+the+severity+of+subsequent+withdrawal+seizures%3A+an+animal+model+of+alcohol+withdrawal+%22kindling%22.&rft.au=Becker%2C+H+C%3BHale%2C+R+L&rft.aulast=Becker&rft.aufirst=H&rft.date=1993-02-01&rft.volume=17&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-12 N1 - Date created - 1993-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Measurement of nitric oxide in biological models. AN - 75603584; 8440411 AB - Nitric oxide (NO) is a small, gaseous, paramagnetic radical with a high affinity for interaction with ferrous hemoproteins such as soluble guanylate cyclase and hemoglobin. Interest in NO measurement increased exponentially with the discovery that NO or a related compound is the endothelium-derived relaxing factor (EDRF). In addition to being a potent endogenous vasodilator, NO has a role in inflammation, thrombosis, immunity, and neurotransmission. Measurement of NO is important as many of its effects (e.g., vasodilatation, inhibition of platelet aggregation) are similar to those of other substances produced by the endothelium, such as prostacyclin. NO is formed in small amounts in vivo and is rapidly destroyed by interaction with oxygen, making measurement difficult. A computerized search of the past five year's literature found NO measurements reported in fewer than 50 of 955 articles dealing with EDRF. Inhibitors of NO synthesis such as the arginine analogs or agents that inactivate NO, such as reduced hemoglobin, are commonly used as specific probes for NO, in vivo and in vitro; however, none of the NO inhibitors is completely specific. The most widely used assays use one of three strategies to detect NO: 1) NO is "trapped" by nitroso compounds, or reduced hemoglobin, forming a stable adduct that is detected by electron paramagnetic resonance (EPR) (detection threshold approximately 1 nmol); 2) NO oxidizes reduced hemoglobin to methemoglobin, which is detected by spectrophotometry (detection threshold approximately 1 nmol); 3) NO interacts with ozone producing light, "chemiluminescence" (detection threshold approximately 20 pmol). These assays can be performed to exclusively detect NO, or by adding acid and reducing agents to the sample, can measure NO and related oxides of nitrogen such as nitrite. Several new amperometric microelectrode assays offer the potential to measure smaller amounts of NO (10(-20) M), permitting NO measurement in intact issues and from single cells. This review describes the pharmacology and toxicology of NO and reviews the major techniques for measuring NO in biological models. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Archer, S AD - Veterans Administration Medical Center Minneapolis, Minnesota 55417. Y1 - 1993/02/01/ PY - 1993 DA - 1993 Feb 01 SP - 349 EP - 360 VL - 7 IS - 2 SN - 0892-6638, 0892-6638 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Humans KW - Nitric Oxide -- analysis KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75603584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Measurement+of+nitric+oxide+in+biological+models.&rft.au=Archer%2C+S&rft.aulast=Archer&rft.aufirst=S&rft.date=1993-02-01&rft.volume=7&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-29 N1 - Date created - 1993-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deoxyribonucleoside triphosphate pools and thymidine chemosensitization in human T-cell leukemia. AN - 75583955; 8429693 AB - Thymidine kills cells by depleting dCTP stores. The present experiments tested whether deoxycytidine, by replenishing dCTP pools, could prevent thymidine cytotoxicity and thymidine's enhancement of carboplatin killing in two human T-cell acute leukemia cell lines. MOLT3 and JM cells were exposed to combinations of thymidine, deoxycytidine, and carboplatin and then assessed for survival, the magnitude of thymidine-carboplatin chemosensitization, and changes in deoxyribonucleoside triphosphate pools. For both cell lines, deoxycytidine (up to 144.5 micrograms/ml x 24 h) completely restored dCTP pools but only partially protected against thymidine cytotoxicity (100-1000 micrograms/ml x 24 h) and thymidine-carboplatin sensitization (up to 60 micrograms carboplatin/ml during the last hour of thymidine). This contrasts with complete protection in prior studies using other cell types. Thymidine alone markedly increased dTTP and dGTP pools and decreased dCTP; dATP pools underwent a sharp decline which has not been observed before in any cell line. In subsequent studies 0.0336-137.3 micrograms deoxyadenosine/ml partially prevented cytotoxicity and carboplatin sensitization by 300 micrograms thymidine/ml. Together, deoxycytidine and deoxyadenosine completely prevented thymidine-carboplatin sensitization even though dATP and dCTP pools were not entirely returned to normal. These findings are discussed in regard to the unusual sensitivity of T-cell malignancies to thymidine toxicity, mechanisms of cytotoxicity and chemosensitization by thymidine, and the possibility of thymidine selectively sensitizing T-cell malignancies to killing by alkylating agents. JF - Leukemia research AU - Cohen, J D AU - Robins, H I AU - Katz, T B AU - Miller, E M AU - Kuzminsky, S R AU - Javid, M J AD - Division of Hematology-Oncology, Denver Veterans Administration Medical Center, CO 80220. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 167 EP - 174 VL - 17 IS - 2 SN - 0145-2126, 0145-2126 KW - Deoxyadenosines KW - 0 KW - Deoxyribonucleotides KW - Deoxycytidine KW - 0W860991D6 KW - Carboplatin KW - BG3F62OND5 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Deoxycytidine -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Deoxyadenosines -- metabolism KW - Carboplatin -- administration & dosage KW - Thymidine -- metabolism KW - Thymidine -- toxicity KW - Leukemia, T-Cell -- metabolism KW - Deoxyribonucleotides -- metabolism KW - Leukemia, T-Cell -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75583955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+research&rft.atitle=Deoxyribonucleoside+triphosphate+pools+and+thymidine+chemosensitization+in+human+T-cell+leukemia.&rft.au=Cohen%2C+J+D%3BRobins%2C+H+I%3BKatz%2C+T+B%3BMiller%2C+E+M%3BKuzminsky%2C+S+R%3BJavid%2C+M+J&rft.aulast=Cohen&rft.aufirst=J&rft.date=1993-02-01&rft.volume=17&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Leukemia+research&rft.issn=01452126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-10 N1 - Date created - 1993-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Childhood Physical Abuse and Combat-Related Posttraumatic Stress Disorder in Vietnam Veterans AN - 61330801; 9404284 AB - Standardized inventory, scale, & checklist data on drawn on to compare rates of childhood physical or sexual abuse among 66 Vietnam veterans with & without combat-related posttraumatic stress disorder (PTSD). Results indicate that PTSD patients report higher rates of childhood abuse. Implications for the prevention & treatment of PTSD are discussed. 1 Table, 58 References. K. Hyatt JF - The American Journal of Psychiatry AU - Bremner, J Douglas AU - Southwick, Steven M AU - Johnson, David R AU - Yehuda, Rachel AU - Charney, Dennis S AD - West Haven Veterans Administration Medical Center, #116S 950 Campbell Ave CT 06516 Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 235 EP - 239 VL - 150 IS - 2 SN - 0002-953X, 0002-953X KW - childhood physical/sexual abuse, Vietnam veterans with/without combat-related posttraumatic stress disorder KW - inventory/scale/checklist data KW - Veterans KW - Combat KW - Sexual Abuse KW - Posttraumatic Stress Disorder KW - Child Abuse KW - Child Sexual Abuse KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61330801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Childhood+Physical+Abuse+and+Combat-Related+Posttraumatic+Stress+Disorder+in+Vietnam+Veterans&rft.au=Bremner%2C+J+Douglas%3BSouthwick%2C+Steven+M%3BJohnson%2C+David+R%3BYehuda%2C+Rachel%3BCharney%2C+Dennis+S&rft.aulast=Bremner&rft.aufirst=J&rft.date=1993-02-01&rft.volume=150&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Sexual Abuse; Veterans; Child Sexual Abuse; Child Abuse; Combat; Posttraumatic Stress Disorder ER - TY - JOUR T1 - Interaction between free radicals and excitatory amino acids in the blood-brain barrier disruption after iron injury in the rat. AN - 76263102; 8145263 AB - Excitatory amino acids and oxygen free radicals have been reported to cooperate in the genesis of brain injury in vivo and in vitro. In this study, we tested the capacity of a noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801, and a 21-aminosteroid, U-74006F, tirilazad mesylate, to block the opening of the blood-brain barrier after subarachnoid injection of FeCl2, which is believed to cause a primarily "pure" free radical insult. Subarachnoid injection of FeCl2 resulted in a significant 10-fold increase in Evans blue extravasation while sham injection or NaCl injection had no effect. Pretreatment with either MK-801 or U-74006F significantly reduced the FeCl2-induced increase in capillary permeability by 43 and 63%, respectively (p < 0.05). Combined treatment with MK-801 and U-74006F resulted in a 65% reduction in vascular leakage that was not significantly greater than pretreatment with either drug alone. These results show that both excitatory amino acids and free radicals can damage the cerebral microvasculature and that an excitatory amino acid antagonist can partially protect the blood-brain barrier after free radical-induced injury. JF - Journal of neurotrauma AU - Zuccarello, M AU - Anderson, D K AD - Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1993 PY - 1993 DA - 1993 SP - 397 EP - 403 VL - 10 IS - 4 SN - 0897-7151, 0897-7151 KW - Amino Acids KW - 0 KW - Chlorides KW - Ferric Compounds KW - Free Radical Scavengers KW - Free Radicals KW - Pregnatrienes KW - Evans Blue KW - 45PG892GO1 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - ferric chloride KW - U38V3ZVV3V KW - tirilazad KW - YD064E883I KW - Index Medicus KW - Animals KW - Pregnatrienes -- pharmacology KW - Dizocilpine Maleate -- pharmacology KW - Rats KW - Subarachnoid Space KW - Rats, Sprague-Dawley KW - Intracranial Pressure -- drug effects KW - Blood Pressure -- drug effects KW - Injections KW - Male KW - Blood-Brain Barrier -- drug effects KW - Ferric Compounds -- administration & dosage KW - Ferric Compounds -- toxicity KW - Amino Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76263102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurotrauma&rft.atitle=Interaction+between+free+radicals+and+excitatory+amino+acids+in+the+blood-brain+barrier+disruption+after+iron+injury+in+the+rat.&rft.au=Zuccarello%2C+M%3BAnderson%2C+D+K&rft.aulast=Zuccarello&rft.aufirst=M&rft.date=1993-01-01&rft.volume=10&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurotrauma&rft.issn=08977151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-05 N1 - Date created - 1994-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of occupational exposure to human immunodeficiency virus 1. AN - 76137753; 8261768 JF - Comprehensive therapy AU - Breeling, J L AD - Medical Service, West Roxbury Veterans Administration Medical Center, Boston, MA 02132. Y1 - 1993 PY - 1993 DA - 1993 SP - 145 EP - 150 VL - 19 IS - 4 SN - 0098-8243, 0098-8243 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Centers for Disease Control and Prevention (U.S.) KW - Risk Factors KW - Humans KW - Guidelines as Topic KW - Universal Precautions KW - HIV Infections -- transmission KW - Infectious Disease Transmission, Patient-to-Professional KW - Occupational Diseases -- prevention & control KW - HIV Infections -- prevention & control KW - Occupational Diseases -- epidemiology KW - Primary Prevention -- methods KW - HIV-1 KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76137753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+therapy&rft.atitle=Prevention+of+occupational+exposure+to+human+immunodeficiency+virus+1.&rft.au=Breeling%2C+J+L&rft.aulast=Breeling&rft.aufirst=J&rft.date=1993-01-01&rft.volume=19&rft.issue=4&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Comprehensive+therapy&rft.issn=00988243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-25 N1 - Date created - 1994-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Progression of amiodarone induced cataracts. AN - 76035993; 8223102 AB - Amiodarone hydrochloride is a potent antiarrhythmic agent recently approved for use by the Food and Drug Administration. Anterior subcapsular lens opacities were observed in seven of fourteen patients treated with moderate to high doses of amiodarone at the Veterans Administration Medical Center in San Francisco in 1982. The present report summarizes the present status of these same fourteen patients ten years later. Anterior subcapsular lens opacities developed or progressed in all patients continuing treatment with this antiarrhythmic agent during the following ten year interval. Although Snellen visual acuities are not decreased, subtle visual impairment is present as measured by contrast sensitivity measurements with and without glare. This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug. JF - Documenta ophthalmologica. Advances in ophthalmology AU - Flach, A J AU - Dolan, B J AD - Department of Ophthalmology, Veterans Administration Hospital, San Francisco, Calif. Y1 - 1993 PY - 1993 DA - 1993 SP - 323 EP - 329 VL - 83 IS - 4 SN - 0012-4486, 0012-4486 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Vision Disorders -- diagnosis KW - Lens, Crystalline -- pathology KW - Contrast Sensitivity KW - Humans KW - Lens, Crystalline -- drug effects KW - Arrhythmias, Cardiac -- drug therapy KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Longitudinal Studies KW - Visual Acuity KW - Male KW - Cataract -- pathology KW - Cataract -- chemically induced KW - Amiodarone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76035993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Documenta+ophthalmologica.+Advances+in+ophthalmology&rft.atitle=Progression+of+amiodarone+induced+cataracts.&rft.au=Flach%2C+A+J%3BDolan%2C+B+J&rft.aulast=Flach&rft.aufirst=A&rft.date=1993-01-01&rft.volume=83&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Documenta+ophthalmologica.+Advances+in+ophthalmology&rft.issn=00124486&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-20 N1 - Date created - 1993-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Response of "benign" metastasizing leiomyoma to progestin withdrawal. Case report. AN - 75679996; 8472731 AB - We report a rare case of a benign metastasizing leiomyoma in which progestin therapy permitted or promoted pulmonary metastases, but progestin withdrawal induced a marked tumor regression. The significance of these observations is discussed relative to the estrogen and progesterone receptor positivity of this patient's tumor. JF - European journal of gynaecological oncology AU - Cohen, J D AU - Robins, H I AD - Division of Hematology/Oncology Denver Veterans Administration Medical Center. Y1 - 1993 PY - 1993 DA - 1993 SP - 44 EP - 45 VL - 14 IS - 1 SN - 0392-2936, 0392-2936 KW - Progesterone Congeners KW - 0 KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Megestrol KW - EA6LD1M70M KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - Megestrol -- therapeutic use KW - Megestrol -- adverse effects KW - Humans KW - Megestrol -- analogs & derivatives KW - Medroxyprogesterone Acetate -- therapeutic use KW - Middle Aged KW - Female KW - Medroxyprogesterone Acetate -- adverse effects KW - Neoplasms, Hormone-Dependent -- secondary KW - Uterine Neoplasms -- drug therapy KW - Progesterone Congeners -- adverse effects KW - Lung Neoplasms -- secondary KW - Uterine Neoplasms -- surgery KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Leiomyoma -- drug therapy KW - Progesterone Congeners -- therapeutic use KW - Lung Neoplasms -- chemically induced KW - Leiomyoma -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75679996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+gynaecological+oncology&rft.atitle=Response+of+%22benign%22+metastasizing+leiomyoma+to+progestin+withdrawal.+Case+report.&rft.au=Cohen%2C+J+D%3BRobins%2C+H+I&rft.aulast=Cohen&rft.aufirst=J&rft.date=1993-01-01&rft.volume=14&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=European+journal+of+gynaecological+oncology&rft.issn=03922936&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-18 N1 - Date created - 1993-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of hypoglycemia on changes of brain lactic acid and intracellular pH produced by ischemia. AN - 75653026; 8457423 AB - Previous investigators have attributed the fall of brain intracellular pH (pHi) produced by ischemia to accumulation of lactic acid. The goal of the present experiments was to examine the hypothesis that the acidosis produced by cerebral ischemia is due to accumulation of lactic acid. The present experiments inhibited lactic acid production by lowering glucose availability using insulin-induced hypoglycemia. The adverse effects of hypoglycemia were prevented by the prior elevation of beta-hydroxybutyric acid and acetoacetic acid induced by a high lipid diet. Brain pHi and lactic acid were measured by 31P and 1H NMR. The results showed that insulin-induced hypoglycemia markedly inhibits production of lactic acid, but has no effect on brain pHi during ischemia. These findings suggest that, at least under some conditions, the acidosis produced by cerebral ischemia is not due to accumulation of lactic acid. JF - NMR in biomedicine AU - Nagai, Y AU - Naruse, S AU - Weiner, M W AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1993 SP - 1 EP - 6 VL - 6 IS - 1 SN - 0952-3480, 0952-3480 KW - Insulin KW - 0 KW - Lactates KW - Phosphates KW - Triglycerides KW - Phosphocreatine KW - 020IUV4N33 KW - Lactic Acid KW - 33X04XA5AT KW - phosphocreatinine KW - 5786-71-0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Triglycerides -- pharmacology KW - Hydrogen-Ion Concentration KW - Phosphocreatine -- analogs & derivatives KW - Intracellular Fluid -- metabolism KW - Phosphates -- metabolism KW - Rats KW - Adenosine Triphosphate -- metabolism KW - Rats, Wistar KW - Phosphocreatine -- metabolism KW - Male KW - Hypoglycemia -- metabolism KW - Lactates -- biosynthesis KW - Hypoglycemia -- physiopathology KW - Brain Ischemia -- metabolism KW - Brain -- metabolism KW - Hypoglycemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75653026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+biomedicine&rft.atitle=Effect+of+hypoglycemia+on+changes+of+brain+lactic+acid+and+intracellular+pH+produced+by+ischemia.&rft.au=Nagai%2C+Y%3BNaruse%2C+S%3BWeiner%2C+M+W&rft.aulast=Nagai&rft.aufirst=Y&rft.date=1993-01-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NMR+in+biomedicine&rft.issn=09523480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-27 N1 - Date created - 1993-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma. AN - 75613818; 8382705 AB - Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition. The effects were compared to LHRH agonist [D-Trp6]LHRH and carriers [D-Lys6]LHRH, LHRH antagonist T-147, as well as to methotrexate, G-HMAQ and surgical bilateral overiectomy. Analysis of the binding data revealed that in control tumors the interaction of 125I-[D-TRP6]LHRH was consistent with the presence of one class of saturable, specific, noncooperative, high-affinity and low-capacity binding sites. Chronic treatment of mice bearing MXT tumors with LHRH analogs AJ-04 and T-121/B carrying cytotoxic radicals, but not with T-98 produced significant down-regulation of membrane receptors for LHRH. The largest decrease in dissociation binding constant and Bmax of receptors for LHRH was also found in animals treated with T-121/B. Specific, high affinity binding of 125I-labelled epidermal growth factor (EGF) was detected in the membranes from control and treated MXT tumors. Treatment with cytotoxic LHRH analogs, AJ-04, T-98 and especially with T-121/B, reduced maximal binding capacity of EGF receptors. Our results indicate that LHRH analogs carrying cytotoxic radicals retain their hormonal activity and inhibit tumor growth while inducing down-regulation of LHRH receptors. In addition, probably both components of the cytotoxic LHRH analog, peptide carriers and cytotoxic radicals, reduce the binding capacity of EGF receptors, which might be useful in the treatment of breast cancer. JF - Journal of cancer research and clinical oncology AU - Milovanovic, S R AU - Monje, E AU - Szepeshazi, K AU - Radulovic, S AU - Schally, A AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1993 PY - 1993 DA - 1993 SP - 273 EP - 278 VL - 119 IS - 5 SN - 0171-5216, 0171-5216 KW - Antineoplastic Agents KW - 0 KW - Drug Carriers KW - Free Radicals KW - Iodine Radioisotopes KW - Receptors, LHRH KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Triptorelin Pamoate KW - 57773-63-4 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Free Radicals -- toxicity KW - Animals KW - Methotrexate -- pharmacology KW - Receptor, Epidermal Growth Factor -- metabolism KW - Cell Membrane -- ultrastructure KW - Amino Acid Sequence KW - Mice KW - Triptorelin Pamoate -- pharmacology KW - Mice, Inbred Strains KW - Kinetics KW - Molecular Sequence Data KW - Cell Membrane -- metabolism KW - Methotrexate -- metabolism KW - Female KW - Mammary Neoplasms, Experimental -- ultrastructure KW - Gonadotropin-Releasing Hormone -- metabolism KW - Receptors, LHRH -- drug effects KW - Antineoplastic Agents -- administration & dosage KW - Mammary Neoplasms, Experimental -- drug therapy KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Mammary Neoplasms, Experimental -- metabolism KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology KW - Receptors, LHRH -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75613818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cancer+research+and+clinical+oncology&rft.atitle=Effect+of+treatment+with+LHRH+analogs+containing+cytotoxic+radicals+on+the+binding+characteristics+of+receptors+for+luteinizing-hormone-releasing+hormone+in+MXT+mouse+mammary+carcinoma.&rft.au=Milovanovic%2C+S+R%3BMonje%2C+E%3BSzepeshazi%2C+K%3BRadulovic%2C+S%3BSchally%2C+A&rft.aulast=Milovanovic&rft.aufirst=S&rft.date=1993-01-01&rft.volume=119&rft.issue=5&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+of+cancer+research+and+clinical+oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-30 N1 - Date created - 1993-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anatomical basis for congenital deformities of the lower extremities. Part I. The hip and thigh. AN - 75562063; 8419627 AB - Congenital deformities frequently produce problems not always discernible at birth. Often, a period of time is required for the development of signs and symptoms. The present discussion presents the intrauterine anatomy of a midterm fetus relative to conditions of the hip and thigh. Cryomicrotomy is used in this study to present the best anatomical evidence of the morphology involved. JF - Journal of the American Podiatric Medical Association AU - McCarthy, D J AU - Gessner, R AD - Surgical Service, Veterans Administration Medical Center, Baltimore, MD. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 18 EP - 28 VL - 83 IS - 1 SN - 8750-7315, 8750-7315 KW - Index Medicus KW - Cryoultramicrotomy KW - Hip Dislocation, Congenital -- embryology KW - Thigh KW - Pelvic Bones -- embryology KW - Humans KW - Foot Deformities, Congenital -- embryology KW - Gestational Age KW - Hip Dislocation, Congenital -- etiology KW - Abnormalities, Drug-Induced -- embryology KW - Leg -- abnormalities KW - Foot Deformities, Congenital -- etiology KW - Muscles -- embryology KW - Abnormalities, Drug-Induced -- etiology KW - Hip Joint -- embryology KW - Hip Joint -- abnormalities KW - Femur -- abnormalities KW - Femur -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75562063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Anatomical+basis+for+congenital+deformities+of+the+lower+extremities.+Part+I.+The+hip+and+thigh.&rft.au=McCarthy%2C+D+J%3BGessner%2C+R&rft.aulast=McCarthy&rft.aufirst=D&rft.date=1993-01-01&rft.volume=83&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immune complex glomerulonephritis with unusual microfibrillar deposits associated with primary bone marrow lymphoma. AN - 75547143; 8418626 AB - Glomerular microfibrillary deposits are characteristic of several diseases of the kidney. In a number of glomerulopathies, the nature of these microfibrillary deposits is critical in classifying the renal lesion and in suggesting the possibility of an associated systemic process. However, it is likely that as efforts are made to classify glomerulopathies with microfibrillary deposits, certain cases will defy categorization. We describe one such case in which a patient presented with rapidly progressive glomerulonephritis associated with large subepithelial, parallel-arrayed microfibrillar deposits associated with a primary bone marrow B-cell lymphoma. While IgG, C3, and lambda and kappa light chains were deposited in the glomerulus, serum and urine protein electrophoresis were normal. Treatment with Cytoxan and prednisone caused simultaneous remission of the lymphoma and the glomerulonephritis. Relapse of the lymphoma was associated with rapid deterioration of renal function. This case may represent a newly described variant of immune complex-mediated glomerulonephritis associated with microfibrillary deposits. The possibility is raised that the glomerular lesion is due to atypical immunoglobulins synthesized by a bone marrow lymphoma. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kohan, D E AU - Perkins, S L AU - Terreros, D A AD - Department of Medicine, Veterans Administration Medical Center, Salt Lake City, UT. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 47 EP - 51 VL - 21 IS - 1 SN - 0272-6386, 0272-6386 KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Drug Therapy, Combination KW - Bone Marrow -- pathology KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Prednisone -- therapeutic use KW - Humans KW - Middle Aged KW - Microscopy, Electron KW - Biopsy KW - Male KW - Immune Complex Diseases -- etiology KW - Glomerulonephritis -- etiology KW - Immune Complex Diseases -- pathology KW - Lymphoma, B-Cell -- drug therapy KW - Lymphoma, B-Cell -- complications KW - Glomerulonephritis -- pathology KW - Lymphoma, B-Cell -- pathology KW - Kidney Glomerulus -- ultrastructure KW - Neoplasm Recurrence, Local -- complications KW - Kidney Glomerulus -- pathology KW - Neoplasm Recurrence, Local -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75547143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Immune+complex+glomerulonephritis+with+unusual+microfibrillar+deposits+associated+with+primary+bone+marrow+lymphoma.&rft.au=Kohan%2C+D+E%3BPerkins%2C+S+L%3BTerreros%2C+D+A&rft.aulast=Kohan&rft.aufirst=D&rft.date=1993-01-01&rft.volume=21&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats. AN - 75546037; 8419233 AB - Intragastric hypertonic (2 mol/L) saline produces injury in the gastric mucosa and a significant increase in gastric blood flow (hyperemia) in anesthetized rats. We studied the mechanism of this hyperemia. Rats were treated with intravenous boluses of NG-nitro-L-arginine methyl ester (3 mg/kg) to block synthesis of endogenous nitric oxide, pyrilamine (1 mg/kg) to inhibit H1 receptors, or indomethacin (5 mg/kg) to block synthesis of endogenous prostaglandins during blood flow studies or with subcutaneous capsaicin (125 mg/kg) 10-14 days before blood flow studies to ablate capsaicin-sensitive afferent nerves. Gastric mucosal blood flow was measured by hydrogen gas clearance before and during intragastric administration of 2 mol/L saline. The gastric hyperemia induced by intragastric 2 mol/L saline was completely blocked only by indomethacin. The associated gastric mucosal damage was increased significantly. In the rat stomach, the gastric hyperemia induced by intragastric 2 mol/L saline is mediated by endogenous prostaglandins and plays a protective role. Endogenous nitric oxide, H1 receptors, and capsaicin-sensitive afferent nerves are not involved in this protective hyperemia. JF - Gastroenterology AU - Endoh, K AU - Kao, J AU - Domek, M J AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, California. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 114 EP - 121 VL - 104 IS - 1 SN - 0016-5085, 0016-5085 KW - Saline Solution, Hypertonic KW - 0 KW - Arginine KW - 94ZLA3W45F KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Intubation, Gastrointestinal KW - Regional Blood Flow -- drug effects KW - Arginine -- pharmacology KW - Indomethacin -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Blood Pressure -- drug effects KW - Blood Volume -- drug effects KW - Arginine -- analogs & derivatives KW - Male KW - Stomach -- pathology KW - Stomach -- blood supply KW - Saline Solution, Hypertonic -- pharmacology KW - Saline Solution, Hypertonic -- administration & dosage KW - Hyperemia -- pathology KW - Hyperemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75546037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mechanism+of+gastric+hyperemia+induced+by+intragastric+hypertonic+saline+in+rats.&rft.au=Endoh%2C+K%3BKao%2C+J%3BDomek%2C+M+J%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1993-01-01&rft.volume=104&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-08 N1 - Date created - 1993-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of Sex on the Induction of Anti-DNA Antibodies in Normal Mice Immunized with Bacterial DNA AN - 745931055; 12895884 AB - Immunization of normal mice with bacterial DNA elicits a significant IgG anti-DNA response and has been explored as a model of systemic Lupus erythematosus. To determine whether this induced response is influenced by sex, we have measured anti-DNA levels in normal male and female BALB/c mice immunized with single stranded DNA from E. coli as complexes with methylated bovine serum albumin (mBSA) in adjuvant. By ELISA assays, anti-DNA levels of immunized females were approximately 16-fold higher than those of immunized males; levels of antibodies to the mBSA carrier were similar, however. The antibodies from females and males showed a similar degree of cross-reactivity when assayed using other natural and synthetic DNA antigens, including mammalian DNA. These findings suggest the potentiation of anti-DNA production in females by antigen-specific mechanisms and provide further evidence that immunization with bacterial DNA replicates features of autoantibody production in SLE. JF - Lupus AU - Palmer, Scott M AU - Gilkeson, Gary S AU - Pisetsky, David S AD - Division of Rheumatology and Immunology, Durham Veterans Administration Hospital, Duke University Medical Center, Durham, NC, USA Y1 - 1993 PY - 1993 DA - 1993 SP - 251 EP - 255 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 1S SN - 0961-2033, 0961-2033 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - SLE Anti-DNA antibodies KW - Sex differences KW - Animal models KW - Enzyme-linked immunosorbent assay KW - Cross-reactivity KW - Potentiation KW - Adjuvants KW - Immunization KW - Autoantibodies KW - Bovine serum albumin KW - Anti-DNA antibodies KW - Escherichia coli KW - Immunoglobulin G KW - Systemic lupus erythematosus KW - Sex KW - A 01490:Miscellaneous KW - N 14820:DNA Metabolism & Structure KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Effect+of+Sex+on+the+Induction+of+Anti-DNA+Antibodies+in+Normal+Mice+Immunized+with+Bacterial+DNA&rft.au=Palmer%2C+Scott+M%3BGilkeson%2C+Gary+S%3BPisetsky%2C+David+S&rft.aulast=Palmer&rft.aufirst=Scott&rft.date=1993-01-01&rft.volume=2&rft.issue=1S&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/10.1177%2F096120339300200112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 25 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Cross-reactivity; Bovine serum albumin; Autoantibodies; Anti-DNA antibodies; Potentiation; Immunoglobulin G; Adjuvants; Systemic lupus erythematosus; Immunization; Sex; Escherichia coli DO - http://dx.doi.org/10.1177/096120339300200112 ER - TY - JOUR T1 - Cationic protein from a urate-calcium oxalate stone: isolation and purification of a shared protein AN - 744635401; 109471 AB - A protein extracted from a urate-calcium oxalate stone by electrodialysis is also excreted in the urine which served as the source material for its purification by FPLC after separation on an ACA44 column. It has an amino acid composition appropriate for a cationic protein. One peptide obtained by cyanogen bromide cleavage has significant (approximately 60%) homology with CD59 protein (protectin). Both proteins have wide distribution, the unknown having been found in bile, cholesterol gallstones, and the wall of the aorta. However, the two proteins appear to be immunologically different. JF - Scanning Microscopy AU - Binette, J P AU - Binette, M B AD - Veterans Administration Medical Centre, Buffalo, NY, USA Y1 - 1993 PY - 1993 DA - 1993 SP - 1107 EP - 1110 VL - 7 IS - 3 SN - 0891-7035, 0891-7035 KW - Biomedical engineering KW - Cationic KW - Immunoblot KW - Stone KW - Urine KW - Urology KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Proteins KW - Characterization KW - W4 462:BIOMEDICAL EQUIPMENT KW - W4 461:BIOENGINEERING KW - W4 801:CHEMISTRY KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744635401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Cationic+protein+from+a+urate-calcium+oxalate+stone%3A+isolation+and+purification+of+a+shared+protein&rft.au=Binette%2C+J+P%3BBinette%2C+M+B&rft.aulast=Binette&rft.aufirst=J&rft.date=1993-01-01&rft.volume=7&rft.issue=3&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Characterization; Proteins ER - TY - JOUR T1 - Psychological Debriefing of Returning Military Personnel: A Protocol for Post-Combat Intervention AN - 61346211; 9408417 AB - A twelve-session protocol for debriefing military combatants in small groups is described. Psychological debriefing is an early intervention that aims to reduce the immediate & long-term negative effects of combat-related trauma. It is, ideally, preventive rather than therapeutic. Debriefing sessions should be conducted as soon after combat as possible to prevent early reactions & the formation of negative coping behaviors. Other general guidelines include initial screening to identify appropriate participants & channel severely disturbed individuals to treatment, reinforcement of the expectation of success, separation of married individuals to special sessions, & the use of skilled group facilitators. The specific session-by-session details of the flexible protocol are provided, & session objectives & content are discussed. 1 Appendix, 33 References. Adapted from the source document. JF - Journal of Social Behavior and Personality AU - Hayman, Peter M AU - Scaturo, Douglas J AD - Dept Veterans Affairs Veterans Administration Medical Center, Bay Pines FL 33504 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 117 EP - 130 VL - 8 SN - 0886-1641, 0886-1641 KW - military combatants, psychological debriefing protocol KW - Prevention KW - Military Personnel KW - Intervention KW - Posttraumatic Stress Disorder KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61346211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Behavior+and+Personality&rft.atitle=Psychological+Debriefing+of+Returning+Military+Personnel%3A+A+Protocol+for+Post-Combat+Intervention&rft.au=Hayman%2C+Peter+M%3BScaturo%2C+Douglas+J&rft.aulast=Hayman&rft.aufirst=Peter&rft.date=1993-01-01&rft.volume=8&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Behavior+and+Personality&rft.issn=08861641&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSBPE9 N1 - SubjectsTermNotLitGenreText - Military Personnel; Intervention; Posttraumatic Stress Disorder; Prevention ER - TY - JOUR T1 - Psychological Processes in Traumatic Stress AN - 61339494; 9408434 AB - Posttraumatic stress disorder (PTSD) is a representation of an extreme on a continuum of normal reactions to traumatic stress, & not a disease entity. The case for this position is made by tracing the psychological processes involved in PTSD & showing where normal responses become problematic or pathological. The diagnostic criteria for PTSD are reviewed, & an ethological perspective that considers the biological & natural contexts of behavior & the adaptive value of psychological processes is assumed. Normal responses to trauma can become pathological when taken to extremes; eg, denial can become extreme avoidance if drugs are used to keep memory suppressed. 3 Tables, 56 References. Adapted from the source document. JF - Journal of Social Behavior and Personality AU - Weiss, Daniel S AD - Veterans Administration Medical Center U California, San Francisco 94143 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 3 EP - 28 VL - 8 SN - 0886-1641, 0886-1641 KW - posttraumatic stress disorder, psychological processes KW - Psychological Factors KW - Posttraumatic Stress Disorder KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61339494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Behavior+and+Personality&rft.atitle=Psychological+Processes+in+Traumatic+Stress&rft.au=Weiss%2C+Daniel+S&rft.aulast=Weiss&rft.aufirst=Daniel&rft.date=1993-01-01&rft.volume=8&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Behavior+and+Personality&rft.issn=08861641&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSBPE9 N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Psychological Factors ER - TY - JOUR T1 - Case Management in Two Long-Term-Care Populations: A Synthesis of Research AN - 1761714149; 199501005 AB - Synthesizes 137 empirical investigations of case management of functionally limited elderly & chronically mentally ill adult long-term care populations, comparing the implications for practice, program, & policy development. Findings distinguish three major variables related to case management for these populations: (1) the goals or outcome variables for case management may affect the timing of case management services & the course of care for each population; (2) the availability & function of informal supports is developmentally different for the two groups; & (3) there is a need for varying constellations of services for different long-term care populations. 31 References. Adapted from the source document. JF - Journal of Case Management AU - Damron-Rodriguez, JoAnn AD - Geriatric Research Education Clinical Center Veterans Administration West Los Angeles, Wilshire & Sawtelle Blvds CA 90033 Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 125 EP - 129 VL - 2 IS - 4 SN - 1061-3706, 1061-3706 KW - case management, elderly/mentally ill long-term care populations KW - empirical research review KW - Mental Patients KW - Chronic Illness KW - Elderly KW - Social Work Cases KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761714149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Case+Management&rft.atitle=Case+Management+in+Two+Long-Term-Care+Populations%3A+A+Synthesis+of+Research&rft.au=Wood%2C+W+G%3BRao%2C+A+M%3BIgbavboa%2C+U%3BSemotuk%2C+M&rft.aulast=Wood&rft.aufirst=W&rft.date=1993-04-01&rft.volume=17&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Social Work Cases; Mental Patients; Chronic Illness ER - TY - JOUR T1 - Self-Report of Depression in Elderly with and without Progressive Cognitive Deterioration AN - 1761711744; 199402430 AB - Scale data obtained from 19 patients diagnosed with probable Alzheimer's disease (AD), 27 elderly depressed with no cognitive decline, & 8 elderly depressed with cognitive decline at an initial evaluation & 2 years later reveal no differences among groups in total depression score at either test period. A within-group repeated measures t-test found those depressed with no cognitive decline to be less depressed at follow-up. Clustering scale items into emotional, cognitive, & behavioral domains revealed those depressed with no cognitive decline to endorse a greater number of emotional content items than the other 2 samples. Patients with progressive cognitive decline endorsed a minimal number of cognitive items, suggesting little insight into their illness. 3 Tables, 1 Figure, 25 References. Adapted from the source document. JF - Clinical Gerontologist AU - Nussbaum, Paul David AU - Sauer, Lori AD - Veterans Administration Medical Center (151-R) Highland Dr Pittsburgh PA 15206 Y1 - 1993///0, PY - 1993 DA - 0, 1993 SP - 69 EP - 80 VL - 13 IS - 1 SN - 0731-7115, 0731-7115 KW - depression self-report, elderly Alzheimer's patients KW - cognitive decline KW - scale data KW - Measurement KW - Psychological Factors KW - Depression (Psychology) KW - Alzheimer's Disease KW - Elderly KW - Verbal Accounts KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761711744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Self-Report+of+Depression+in+Elderly+with+and+without+Progressive+Cognitive+Deterioration&rft.au=Nussbaum%2C+Paul+David%3BSauer%2C+Lori&rft.aulast=Nussbaum&rft.aufirst=Paul&rft.date=1993-01-01&rft.volume=13&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Elderly; Alzheimer's Disease; Measurement; Verbal Accounts; Psychological Factors ER - TY - JOUR T1 - Caffeine use as a model of acute and chronic insomnia. AN - 73470992; 1475567 AB - It was hypothesized that the metabolic effects of caffeine, which can be objectively measured (i.e. physiological, "arousal"), could be used to develop a physiological arousal model of chronic insomnia in a group of normal young adults. Twelve normal young adult males participated for 11 nights after laboratory adaptation. Subjects received 400 mg of caffeine three times a day for 7 nights and days. As predicted, the use of caffeine resulted in increased metabolic rate. Sleep efficiency was significantly reduced by caffeine and multiple sleep latency tests (MSLTs) were significantly increased. Some adaptation to the metabolic, sleep efficiency, and MSLT effects of caffeine was seen over the week of administration. Withdrawal effects (i.e. rebound sleep or sleepiness) were not seen for metabolic, MSLT or sleep variables. The data indicated that caffeine was effective in producing significant metabolic and sleep effects and that those effects were related. The results were consistent with the interpretation that a chronic decrease in sleep efficiency associated with increased physiological arousal, although producing subjective dysphoria, does not produce a physiological sleep debt. JF - Sleep AU - Bonnet, M H AU - Arand, D L AD - Dayton Veterans Administration Medical Center, Ohio. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 526 EP - 536 VL - 15 IS - 6 SN - 0161-8105, 0161-8105 KW - Caffeine KW - 3G6A5W338E KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Acute Disease KW - Drug Administration Schedule KW - Substance Withdrawal Syndrome -- physiopathology KW - Humans KW - Energy Metabolism -- physiology KW - Circadian Rhythm -- drug effects KW - Arousal -- physiology KW - Personality Inventory KW - Psychomotor Performance -- physiology KW - Polysomnography KW - Circadian Rhythm -- physiology KW - Psychomotor Performance -- drug effects KW - Arousal -- drug effects KW - Oxygen -- blood KW - Energy Metabolism -- drug effects KW - Adult KW - Attention -- physiology KW - Substance Withdrawal Syndrome -- psychology KW - Chronic Disease KW - Models, Neurological KW - Attention -- drug effects KW - Adolescent KW - Male KW - Caffeine -- administration & dosage KW - Caffeine -- adverse effects KW - Sleep Initiation and Maintenance Disorders -- chemically induced KW - Sleep Initiation and Maintenance Disorders -- physiopathology KW - Sleep Initiation and Maintenance Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73470992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sleep&rft.atitle=Caffeine+use+as+a+model+of+acute+and+chronic+insomnia.&rft.au=Bonnet%2C+M+H%3BArand%2C+D+L&rft.aulast=Bonnet&rft.aufirst=M&rft.date=1992-12-01&rft.volume=15&rft.issue=6&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Sleep&rft.issn=01618105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-01 N1 - Date created - 1993-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of castration-induced menopausal symptoms with low dose diethylstilbestrol in men with advanced prostate cancer. AN - 73451006; 1281587 AB - Menopausal symptoms manifesting as hot flashes and sweats occur in up to 75 percent of patients following either orchiectomy or treatment with a luteinizing hormone-releasing hormone agonist for prostate cancer. As many as one third of these patients will experience symptoms severe enough to seek palliation. We treated 12 such patients with low dose diethylstilbestrol (1/3 mg daily). Nine patients demonstrated both objective and subjective improvement in their menopausal symptoms. Five patients experienced toxicity including new onset of gynecomastia or breast soreness although no patient discontinued treatment on this basis. No cardiovascular complications were noted. We conclude that low dose diethylstilbestrol is an inexpensive, effective means of controlling troublesome postorchiectomy menopausal symptoms in carefully selected patients. JF - Urology AU - Miller, J I AU - Ahmann, F R AD - Section of Urology and Hematology/Oncology, Tucson Veterans Administration Medical Center, Arizona. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 499 EP - 502 VL - 40 IS - 6 SN - 0090-4295, 0090-4295 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Prospective Studies KW - Humans KW - Gynecomastia -- chemically induced KW - Palliative Care KW - Aged KW - Middle Aged KW - Male KW - Orchiectomy -- adverse effects KW - Prostatic Neoplasms -- epidemiology KW - Diethylstilbestrol -- therapeutic use KW - Diethylstilbestrol -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Climacteric -- drug effects KW - Diethylstilbestrol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73451006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Treatment+of+castration-induced+menopausal+symptoms+with+low+dose+diethylstilbestrol+in+men+with+advanced+prostate+cancer.&rft.au=Miller%2C+J+I%3BAhmann%2C+F+R&rft.aulast=Miller&rft.aufirst=J&rft.date=1992-12-01&rft.volume=40&rft.issue=6&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=00904295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-15 N1 - Date created - 1993-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of nonsteroidal antiinflammatory drug-induced gastric ulcers with misoprostol. A double-blind multicenter study. AN - 73417401; 1473430 AB - One hundred sixty-two patients chronically ingesting ibuprofen, piroxicam, or naproxen for osteoarthritis, who had abdominal pain and an endoscopically proven gastric ulcer were evaluated for eight weeks in a randomized, double-blind trial comparing misoprostol (200 micrograms four times daily with meals and at bedtime) (N = 77) with placebo (N = 85). Patients discontinued their usual daily dose of antiarthritic medication throughout the study period, and an endoscopy was performed at four weeks and eight weeks (if necessary) to assess ulcer healing. Gastric ulcers were defined as circumscribed breaks in the gastric mucosa of 0.3 cm in diameter or greater. Misoprostol therapy significantly accelerated the rate of gastric ulcer healing compared to placebo (P = 0.033). The cumulative percent healed after four and eight weeks of therapy for misoprostol versus placebo were: 83% vs 61% at four weeks and 96% vs 90% at eight weeks (P = 0.0028 and P = 0.0977, respectively by lifetable analysis). Relief of abdominal pain did not differ significantly between the treatment groups. Misoprostol significantly accelerates the healing of ibuprofen-, piroxicam-, or naproxen-induced gastric ulcers. JF - Digestive diseases and sciences AU - Jaszewski, R AU - Graham, D Y AU - Stromatt, S C AD - Veterans Administration Medical Center, Wayne State University Affiliate Hospital, Allen Park, Michigan 48101. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1820 EP - 1824 VL - 37 IS - 12 SN - 0163-2116, 0163-2116 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Misoprostol KW - 0E43V0BB57 KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Middle Aged KW - Male KW - Female KW - Stomach Ulcer -- drug therapy KW - Misoprostol -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Misoprostol -- therapeutic use KW - Stomach Ulcer -- pathology KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73417401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Treatment+of+nonsteroidal+antiinflammatory+drug-induced+gastric+ulcers+with+misoprostol.+A+double-blind+multicenter+study.&rft.au=Jaszewski%2C+R%3BGraham%2C+D+Y%3BStromatt%2C+S+C&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1992-12-01&rft.volume=37&rft.issue=12&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of fructose feeding on glomerular structure in the rat. AN - 73414540; 1477329 JF - Journal of the American Society of Nephrology : JASN AU - Park, S K AU - Meyer, T W AD - Department of Medicine, Palo Alto Veterans Administration Medical Center, CA 94304. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1330 EP - 1332 VL - 3 IS - 6 SN - 1046-6673, 1046-6673 KW - Fructose KW - 30237-26-4 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Insulin Resistance KW - Blood Pressure -- drug effects KW - Time Factors KW - Male KW - Kidney Glomerulus -- injuries KW - Fructose -- toxicity KW - Kidney Glomerulus -- drug effects KW - Kidney Glomerulus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73414540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=The+effects+of+fructose+feeding+on+glomerular+structure+in+the+rat.&rft.au=Park%2C+S+K%3BMeyer%2C+T+W&rft.aulast=Park&rft.aufirst=S&rft.date=1992-12-01&rft.volume=3&rft.issue=6&rft.spage=1330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-05 N1 - Date created - 1993-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intragastric nicotine protection against 40% ethanol injury in rat stomach. Role of ganglionic stimulation or blockade. AN - 73413515; 1361905 AB - Intragastric nicotine (4 mg/kg) protects against 40% ethanol-induced gastric mucosal injury and raises mean blood pressure. We postulated that this protective effect was mediated by the ganglionic stimulatory property of nicotine and therefore could be abolished by ganglionic blockers. Rats were pretreated with intraperitoneal hexamethonium (10 mg/kg) or mecamylamine (2 mg/kg) to block peripheral or central autonomic ganglia, respectively. Intragastric vehicle or nicotine (4 mg/kg) was then administered. The total lengths of the linear gastric corpus mucosal lesions induced by intragastric 40% ethanol were measured by an unbiased observer using a caliper. The results showed that both intraperitoneal hexamethonium and mecamylamine pretreatments protected against 40% ethanol-induced gastric mucosal injury. Neither modified the protective effect of intragastric nicotine. The protective effect of hexamethonium and mecamylamine was associated with a significant increase in the volume of gastric mucus and gastric juice. The increase in the volume of gastric content (mucus and juice) was partially responsible for the protective effect of these ganglionic blockers. In a separate experiment, intraperitoneal nicotine (4 mg/kg) also protected against 40% ethanol-induced gastric mucosal injury and raised mean blood pressure. These data indicate that the protection against 40% ethanol-induced gastric mucosal injury is not unique to intragastric nicotine. Such protection can be induced by ganglionic blocking doses of hexamethonium and mecamylamine, or a ganglionic stimulatory dose of intraperitoneally administered nicotine. Whether ganglionic stimulation or blockade plays a role in the mechanism of intragastric nicotine protection, however, remains to be determined.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Digestive diseases and sciences AU - Endoh, K AU - Kao, J AU - Baker, M AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center 91343. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1840 EP - 1846 VL - 37 IS - 12 SN - 0163-2116, 0163-2116 KW - Ganglionic Blockers KW - 0 KW - Ganglionic Stimulants KW - Hexamethonium Compounds KW - Hexamethonium KW - 3C9PSP36Z2 KW - Ethanol KW - 3K9958V90M KW - Mecamylamine KW - 6EE945D3OK KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Gastric Juice -- secretion KW - Ganglionic Blockers -- pharmacology KW - Ganglionic Stimulants -- pharmacology KW - Blood Pressure -- drug effects KW - Infusions, Parenteral KW - Hexamethonium Compounds -- pharmacology KW - Male KW - Mucus -- secretion KW - Ganglia, Sympathetic -- physiology KW - Nicotine -- administration & dosage KW - Mecamylamine -- pharmacology KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73413515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+nicotine+protection+against+40%25+ethanol+injury+in+rat+stomach.+Role+of+ganglionic+stimulation+or+blockade.&rft.au=Endoh%2C+K%3BKao%2C+J%3BBaker%2C+M%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1992-12-01&rft.volume=37&rft.issue=12&rft.spage=1840&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - One more look at carbamazepine in the treatment of alcohol withdrawal. AN - 73398058; 1471775 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1174 EP - 1175 VL - 16 IS - 6 SN - 0145-6008, 0145-6008 KW - Carbamazepine KW - 33CM23913M KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - Oxazepam -- therapeutic use KW - Double-Blind Method KW - Humans KW - Adult KW - Neurologic Examination -- drug effects KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Carbamazepine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73398058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=One+more+look+at+carbamazepine+in+the+treatment+of+alcohol+withdrawal.&rft.au=Gallant%2C+D+M&rft.aulast=Gallant&rft.aufirst=D&rft.date=1992-12-01&rft.volume=16&rft.issue=6&rft.spage=1174&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-27 N1 - Date created - 1993-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amiodarone-induced endothelial injury is associated with phospholipase C-mediated hydrolysis of membrane phospholipids. AN - 73386577; 1453116 AB - Phospholipids accumulate within the lysosomes of various cells from individuals taking amiodarone. Studies on cultured cells suggest that inhibition of lysosomal phospholipase A1 and phospholipase A2 by amiodarone may be responsible for this derangement in phospholipid metabolism. Inhibition of lysosomal phospholipases by amiodarone has been suggested as a mechanism of its toxicity, but this relationship has not been clearly established. To examine this question, membrane phospholipids of cultured bovine pulmonary artery endothelial cells (BPAEC) were labeled with 14C-stearic acid, 3H-arachidonic acid, 14C-choline, or 14C-ethanolamine. Radiolabeled BPAEC were then exposed to various concentrations of amiodarone, and endothelial phospholipase activity was measured by isolating and quantifying various phospholipase products. These findings were compared to a standard indicator of endothelial cytotoxicity using 51Cr release. Six-hour exposures to 5 to 20 micrograms/ml amiodarone produced no BPAEC toxicity and were accompanied by some evidence of decreased phospholipid hydrolysis. At concentrations above 20 micrograms/ml, amiodarone caused significant BPAEC toxicity as indicated by 51Cr release, and this was closely associated with the liberation of substantial amounts of 3H-arachidonic acid and 14C-stearic acid from phosphatidylcholine and phosphatidylethanolamine. In BPAEC labeled with 14C-choline and 14C-ethanolamine, cytotoxic doses of amiodarone caused accumulations of 14C-phosphocholine and phosphorylethanolamine, expected products of phospholipase C, but without increases in phospholipase A products. We conclude that exposure of BPAEC to toxic concentrations of amiodarone is associated with extensive hydrolysis of phosphatidylcholine and lysophosphatidylethanolamine via a phospholipase C-specific mechanism, and suggest that this may be a mechanism in the pathogenesis of amiodarone toxicity. JF - The Journal of laboratory and clinical medicine AU - Duane, P G AU - Rice, K L AU - Charboneau, D E AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 955 EP - 963 VL - 120 IS - 6 SN - 0022-2143, 0022-2143 KW - Fatty Acids, Nonesterified KW - 0 KW - Membrane Lipids KW - Phospholipids KW - Type C Phospholipases KW - EC 3.1.4.- KW - Amiodarone KW - N3RQ532IUT KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cattle KW - Cells, Cultured KW - Hydrolysis KW - Fatty Acids, Nonesterified -- metabolism KW - Endothelium, Vascular -- drug effects KW - Phospholipids -- metabolism KW - Membrane Lipids -- metabolism KW - Type C Phospholipases -- physiology KW - Amiodarone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73386577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Amiodarone-induced+endothelial+injury+is+associated+with+phospholipase+C-mediated+hydrolysis+of+membrane+phospholipids.&rft.au=Duane%2C+P+G%3BRice%2C+K+L%3BCharboneau%2C+D+E%3BNiewoehner%2C+D+E&rft.aulast=Duane&rft.aufirst=P&rft.date=1992-12-01&rft.volume=120&rft.issue=6&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-06 N1 - Date created - 1993-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of T-cell subsets in the response to anti-CD3 monoclonal antibodies. AN - 73386223; 1360341 AB - Administration of monoclonal antibodies (mAb) to CD3 elicits an immune response to the mAb and an acute toxic syndrome that has been attributed to the release of cytokines from activated T cells. To clarify the cellular basis for these effects, we used anti-lymphocyte mAb to deplete selected T-cell subsets from BALB/c mice prior to administration of anti-CD3. In our first series of experiments, anti-CD4 repeatedly blocked the immune response to anti-CD3, but did not prevent severe toxicity. This observation suggested that other T-cell subsets might contribute to anti-CD3 induced toxicity. Therefore, we treated mice with mAb to CD8 as well as mAb to CD4 prior to administration of anti-CD3. Despite depletion of > 95% of CD8+ and CD4+ T cells, toxicity was not suppressed. This finding cast doubt on the belief that toxicity is due to activation of either CD4+ or CD8+ T cells by anti-CD3. Therefore, we assessed the role of thymocytes (which are not deleted by the mAb) and gamma delta + T cells. Thymectomy did not prevent toxicity in CD4/CD8-depleted mice, demonstrating that thymocytes are not responsible for toxicity. Anti-alpha beta TCR mAb produced a toxic reaction similar to anti-CD3 whereas anti-gamma delta TCR mAb did not, suggesting that gamma delta+ T cells are not the source of toxic cytokines. In addition, we proved that anti-CD3-induced toxicity was not due to direct effects on macrophages or to other nonspecific factors associated with the hamster mAb. These findings imply that a few residual mature T cells in mice treated with mAb to CD4 and CD8 are sufficient for the full expression of the anti-CD3-induced toxic syndrome. To confirm that both CD4+ and CD8+ T cells can mediate toxicity, we showed that:(i) SCID mice, which normally do not develop anti-CD3-induced toxicity, can be rendered susceptible by reconstitution with purified CD4+ T cells; and (ii) CD4-knockout mice that lack CD4+ T cells but have normal CD8+ T cells are susceptible to anti-CD3-induced toxicity. These findings establish that both CD4+ and CD8+ cells contribute to the toxic effects of anti-CD3, and that relatively few cells are required to mediate the full effect. JF - Clinical immunology and immunopathology AU - Finck, B K AU - Yung, C M AU - Carteron, N L AU - Wofsy, D AD - Arthritis/Immunology Section, Veterans Administration Medical Center, San Francisco, California. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 234 EP - 241 VL - 65 IS - 3 SN - 0090-1229, 0090-1229 KW - Antibodies, Anti-Idiotypic KW - 0 KW - Antibodies, Monoclonal KW - Antigens, CD3 KW - Antigens, CD4 KW - Antigens, CD8 KW - Index Medicus KW - Lymphocyte Activation KW - Thymus Gland -- cytology KW - Animals KW - Lymphocyte Depletion KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice, Nude KW - Mice KW - Mice, SCID KW - Mice, Inbred BALB C KW - Antigens, CD4 -- immunology KW - Antigens, CD8 -- immunology KW - Antigens, CD3 -- immunology KW - Antibodies, Monoclonal -- toxicity KW - T-Lymphocyte Subsets -- immunology KW - Antibodies, Anti-Idiotypic -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73386223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+immunology+and+immunopathology&rft.atitle=The+role+of+T-cell+subsets+in+the+response+to+anti-CD3+monoclonal+antibodies.&rft.au=Finck%2C+B+K%3BYung%2C+C+M%3BCarteron%2C+N+L%3BWofsy%2C+D&rft.aulast=Finck&rft.aufirst=B&rft.date=1992-12-01&rft.volume=65&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Clinical+immunology+and+immunopathology&rft.issn=00901229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-07 N1 - Date created - 1993-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Postoperative hypertension: a multicenter, prospective, randomized comparison between intravenous nicardipine and sodium nitroprusside. AN - 73367702; 1458938 AB - To compare the efficacy and safety of iv nicardipine with sodium nitroprusside in the treatment of postoperative hypertension after both cardiac and noncardiac surgery. Multicenter, prospective, randomized, open-label study. Six tertiary referral medical centers (recovery rooms and surgical ICUs). A total of 139 patients with postoperative hypertension: i.v. nicardipine (n = 71), sodium nitroprusside (n = 68). Administration of i.v. nicardipine or sodium nitroprusside. Vital signs (BP, heart rate), hemodynamic variables, medication dosage, total number of dose changes, and time to achieve BP control were recorded. Both medications were equally effective in reducing BP in both the cardiac and noncardiac surgical groups. Under the conditions of the study, i.v. nicardipine controlled hypertension more rapidly than sodium nitroprusside (i.v. nicardipine 14.0 +/- 1.0 mins and sodium nitroprusside 30.4 +/- 3.5 mins, p = .0029). The total number of dose changes required to achieve therapeutic BP response was significantly less in the i.v. nicardipine-treated patients (i.v. nicardipine 1.5 +/- 0.2 vs. sodium nitroprusside 5.1 +/- 1.4, p < .05). Adverse effects were observed with both drugs (i.v. nicardipine 7% [5/71] and sodium nitroprusside 18% [12/68] [NS]). Intravenous nicardipine is as effective as sodium nitroprusside in the therapy of postoperative hypertension. Specific advantages have been identified. The use of i.v. nicardipine should be considered in the therapy of postoperative hypertension. JF - Critical care medicine AU - Halpern, N A AU - Goldberg, M AU - Neely, C AU - Sladen, R N AU - Goldberg, J S AU - Floyd, J AU - Gabrielson, G AU - Greenstein, R J AD - Department of Anesthesiology, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1637 EP - 1643 VL - 20 IS - 12 SN - 0090-3493, 0090-3493 KW - Nitroprusside KW - 169D1260KM KW - Nicardipine KW - CZ5312222S KW - Abridged Index Medicus KW - Index Medicus KW - Postoperative Complications -- drug therapy KW - Hemodynamics -- drug effects KW - Analysis of Variance KW - Prospective Studies KW - Humans KW - Cardiac Surgical Procedures KW - Nicardipine -- adverse effects KW - Aged KW - Middle Aged KW - Nicardipine -- therapeutic use KW - Male KW - Female KW - Survival Analysis KW - Nitroprusside -- therapeutic use KW - Nitroprusside -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73367702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Postoperative+hypertension%3A+a+multicenter%2C+prospective%2C+randomized+comparison+between+intravenous+nicardipine+and+sodium+nitroprusside.&rft.au=Halpern%2C+N+A%3BGoldberg%2C+M%3BNeely%2C+C%3BSladen%2C+R+N%3BGoldberg%2C+J+S%3BFloyd%2C+J%3BGabrielson%2C+G%3BGreenstein%2C+R+J&rft.aulast=Halpern&rft.aufirst=N&rft.date=1992-12-01&rft.volume=20&rft.issue=12&rft.spage=1637&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=00903493&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-08 N1 - Date created - 1993-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interferon-alpha prevents endotoxin-induced mortality in mice. AN - 73365091; 1446703 AB - Endotoxins, the lipopolysaccharide (LPS) moieties on the bacterial cell wall, cause many of the pathological features of Gram-negative septicemia. Tumor necrosis factor (TNF), primarily a product of monocyte/macrophages, has been shown to mediate many of the pathophysiological effects of endotoxin. Kupffer cells, the largest macrophage population in the body, release TNF when stimulated by LPS in vitro. A recombinant human hybrid interferon-alpha A/D (rIFN-alpha) markedly inhibited this LPS-elicited TNF production by Kupffer cells. The effects of rIFN-alpha were further tested in C57BL/6 mice receiving a lethal dose (400 micrograms/mouse) of LPS. All LPS-treated mice died within 2 days. Pretreatment with rIFN-alpha 1 h before LPS challenge improved the survival at 3 days to 22% (5/23, p < 0.04). In contrast, rIFN-alpha was more effective when administered 20 min after LPS injection, increasing the survival rate to 81% (13/16, p < 0.0001). TNF mRNA expression in the liver and spleen 50 min after LPS challenge, and plasma TNF 1.5 h after LPS were also reduced by either pretreatment or post-treatment with rIFN-alpha. Subsequently, experiments were carried out to test the efficacy of delayed rIFN-alpha treatment. A significant protective effect was still apparent when rIFN-alpha was administered 6, 10 and even 14 h (81%, 62% and 28% survival, respectively) after LPS challenge when serum TNF levels had already returned to near baseline. These experimental results suggest that rIFN-alpha might have a therapeutic potential for the prevention and treatment of the deleterious effects associated with endotoxemia besides mechanisms initially blocking TNF production. JF - European journal of immunology AU - Tzung, S P AU - Mahl, T C AU - Lance, P AU - Andersen, V AU - Cohen, S A AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, NY 14215. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 3097 EP - 3101 VL - 22 IS - 12 SN - 0014-2980, 0014-2980 KW - Interferon Type I KW - 0 KW - Lipopolysaccharides KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Mice KW - Female KW - Interferon Type I -- pharmacology KW - Lipopolysaccharides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73365091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=Interferon-alpha+prevents+endotoxin-induced+mortality+in+mice.&rft.au=Tzung%2C+S+P%3BMahl%2C+T+C%3BLance%2C+P%3BAndersen%2C+V%3BCohen%2C+S+A&rft.aulast=Tzung&rft.aufirst=S&rft.date=1992-12-01&rft.volume=22&rft.issue=12&rft.spage=3097&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-29 N1 - Date created - 1992-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Religious Coping and Depression among Elderly, Hospitalized Medically Ill Men AN - 61306712; 93Z8779 AB - An examination of the role of religious belief & behaviors in managing depression in a sample of 850 medically ill males age 65+, consecutively admitted to a southern US hospital. Ss were interviewed for coping techniques & religious affiliation, & depression was measured using the Geriatric Depression Scale & Hamilton Rating Scale for Depression. Findings show that men from conservative, black, & fundamentalist Protestant denominations were especially likely to use religious coping (RC). Older age, black race, retirement status, social support, & history of psychiatric problems were correlated with RC strategies. RC index scores were inversely correlated with Hamilton depression scale scores. No significant relation was found between RC & functional status. 6 Tables, 38 References. I. Shagrir JF - The American Journal of Psychiatry AU - Koenig, Harold G AU - Cohen, Harvey J AU - Blazer, Dan G AU - Pieper, Carl AU - Meador, Keith G AU - Shelp, Frank AU - Goli, Veeraindar AU - DiPasquale, Bob AD - GRECC-Veterans Administration Medical Center, 508 Fulton St Durham NC 27705 Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 1693 EP - 1700 VL - 149 IS - 12 SN - 0002-953X, 0002-953X KW - depression coping strategies, medically ill male elderly KW - religious belief/behaviors KW - interview/scale data KW - hospital patients, southern US KW - Depression (Psychology) KW - Males KW - Elderly KW - Patients KW - Coping KW - Black Community KW - Illness KW - Religious Beliefs KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61306712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Religious+Coping+and+Depression+among+Elderly%2C+Hospitalized+Medically+Ill+Men&rft.au=Koenig%2C+Harold+G%3BCohen%2C+Harvey+J%3BBlazer%2C+Dan+G%3BPieper%2C+Carl%3BMeador%2C+Keith+G%3BShelp%2C+Frank%3BGoli%2C+Veeraindar%3BDiPasquale%2C+Bob&rft.aulast=Koenig&rft.aufirst=Harold&rft.date=1992-12-01&rft.volume=149&rft.issue=12&rft.spage=1693&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Religious Beliefs; Black Community; Coping; Depression (Psychology); Illness; Patients; Elderly; Males ER - TY - JOUR T1 - Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. AN - 73292433; 1385400 AB - Insulin-like growth factor (IGF)-binding proteins (IGFBPs) either inhibit or enhance IGF-stimulated cellular effects. While inhibition occurs by sequestration of IGF from cell-surface receptors, the exact mechanism of IGF-enhancement remains undefined. Human osteoblast-like bone cells in culture secrete several IGF-binding proteins, one of which we have previously identified as IGFBP-5. In this study we purified a 23-kDa IGFBP-5 from cultures of human osteoblast-like cells using ligand affinity chromatography and reversed-phase high performance liquid chromatography and tested its bioactivity in serum-free cultures of normal mouse osteoblast-like cells. Binding studies with radioiodinated IGF showed similar and relatively low affinities for IGF-I and IGF-II consistent with a carboxyl truncated IGF-binding protein. Mitogenic assays demonstrated that the binding protein, when coincubated with IGF-I or -II, enhanced mitogenesis. This enhancement was unique from other binding proteins in not requiring a preincubation period or serum co-factors. Furthermore, the osteoblast-derived IGFBP-5 stimulated mitogenesis in the absence of exogenous or endogenous IGF. Using radioiodinated IGFBP-5 we found that the binding protein could associate with the osteoblast surface, an effect which did not require IGF nor an interaction with IGF receptors. We suggest that osteoblast-derived IGFBP-5 may stimulate osteoblast mitogenesis in at least two ways, by association with IGF and by a second pathway that is independent of IGF receptor activation. JF - The Journal of biological chemistry AU - Andress, D L AU - Birnbaum, R S AD - Medical Service, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1992/11/05/ PY - 1992 DA - 1992 Nov 05 SP - 22467 EP - 22472 VL - 267 IS - 31 SN - 0021-9258, 0021-9258 KW - Carrier Proteins KW - 0 KW - Insulin-Like Growth Factor Binding Protein 5 KW - Insulin-Like Growth Factor Binding Proteins KW - Somatomedins KW - Index Medicus KW - Animals KW - Mitosis KW - Humans KW - In Vitro Techniques KW - Binding, Competitive KW - Mice KW - Drug Synergism KW - Protein Binding KW - Osteoblasts -- physiology KW - Carrier Proteins -- metabolism KW - Somatomedins -- administration & dosage KW - Osteoblasts -- cytology KW - Carrier Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73292433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Human+osteoblast-derived+insulin-like+growth+factor+%28IGF%29+binding+protein-5+stimulates+osteoblast+mitogenesis+and+potentiates+IGF+action.&rft.au=Andress%2C+D+L%3BBirnbaum%2C+R+S&rft.aulast=Andress&rft.aufirst=D&rft.date=1992-11-05&rft.volume=267&rft.issue=31&rft.spage=22467&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-01 N1 - Date created - 1992-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Affective correlates of alcohol and cocaine use. AN - 73446348; 1488932 AB - The affective correlates of alcohol and cocaine use were investigated in two studies. In the first, alcoholics (n = 50) and cocaine addicts (n = 40) were administered factor scales from the Inventory of Drinking Situations as well as the General Temperament Survey. Substance use in negative affect states was reported more often by alcoholics than by cocaine addicts, even when age and race differences were statistically controlled. Alcoholics also reported higher levels of negative temperament, and substance use in negative affect states was correlated with negative temperament across groups. In a study using subjects dependent on both drugs (n = 21), alcohol was more likely to be used in negative affect situations than was cocaine. Thus, the affective correlates of substance use are associated with both individual differences and drug-specific effects. Possible reasons for the differential association of alcohol with negative affect are proposed. JF - Addictive behaviors AU - Cannon, D S AU - Rubin, A AU - Keefe, C K AU - Black, J L AU - Leeka, J K AU - Phillips, L A AD - Psychology Service, Veterans Administration Medical Center, Dallas, TX 75216. PY - 1992 SP - 517 EP - 524 VL - 17 IS - 6 SN - 0306-4603, 0306-4603 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Arousal KW - Humans KW - Adult KW - Temperament KW - Middle Aged KW - Research Design KW - Male KW - Rehabilitation Centers KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73446348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Affective+correlates+of+alcohol+and+cocaine+use.&rft.au=Cannon%2C+D+S%3BRubin%2C+A%3BKeefe%2C+C+K%3BBlack%2C+J+L%3BLeeka%2C+J+K%3BPhillips%2C+L+A&rft.aulast=Cannon&rft.aufirst=D&rft.date=1992-11-01&rft.volume=17&rft.issue=6&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-25 N1 - Date created - 1993-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific and nonspecific effects of ethanol vapor on plasma corticosterone in mice. AN - 73404898; 1472310 AB - The intent of this study was to determine whether chronic ethanol (EtOH) vapor inhalation, with or without adjunct pyrazole (PYR) administration, was stressful in mice, as defined by increases in plasma corticosterone (CORT) concentration. Mice were randomly assigned to groups differentiated both on the basis of EtOH vapor exposure and the presence or absence of PYR administration. Blood samples for blood EtOH concentration (BEC) and plasma CORT concentration were obtained from mice after 72-96 hours of treatment. Mice were sacrificed after 96 hours of treatment and body and adrenal weight determined. BEC was significantly higher in PYR-treated animals and animals treated with the higher EtOH vapor concentration. Plasma CORT was elevated in proportion to BEC; however, other nonspecific stresses, in particular that of PYR administration, also elevated plasma CORT. Nonspecific stresses associated with this protocol may reduce the generality of these observations. Nevertheless, the high correlation between BEC and plasma CORT concentration in the PYR groups indicates that, with suitable control groups, the PYR-EtOH vapor inhalation approach is viable for studies concerned with EtOH effects on hypothalamic-anterior pituitary-adrenocortical function. JF - Alcohol (Fayetteville, N.Y.) AU - Keith, L D AU - Crabbe, J C AD - Research Service, Veterans Administration Medical Center, Portland, OR 97201. PY - 1992 SP - 529 EP - 533 VL - 9 IS - 6 SN - 0741-8329, 0741-8329 KW - Pyrazoles KW - 0 KW - Ethanol KW - 3K9958V90M KW - pyrazole KW - 3QD5KJZ7ZJ KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Pyrazoles -- pharmacology KW - Animals KW - Body Weight -- drug effects KW - Volatilization KW - Mice KW - Adrenal Glands -- drug effects KW - Stress, Physiological -- blood KW - Administration, Inhalation KW - Male KW - Organ Size -- drug effects KW - Ethanol -- blood KW - Corticosterone -- blood KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73404898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Specific+and+nonspecific+effects+of+ethanol+vapor+on+plasma+corticosterone+in+mice.&rft.au=Keith%2C+L+D%3BCrabbe%2C+J+C&rft.aulast=Keith&rft.aufirst=L&rft.date=1992-11-01&rft.volume=9&rft.issue=6&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-29 N1 - Date created - 1993-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Desipramine treatment of cocaine dependence in methadone-maintained patients. AN - 73349866; 1444727 AB - We performed a double-blind, placebo-controlled, randomized 12-week trial of desipramine hydrochloride treatment of cocaine dependence among methadone-maintained patients. Fifty-nine patients completed the 12-week medication trial (36 received desipramine and 23 received placebo), and 94% were recontacted 1, 3, and 6 months after treatment. There were significantly more dropouts in the desipramine than in the placebo group. Baseline to 12-week comparisons of Addiction Severity Index interview data indicated that both groups showed improvements. At 12 weeks, the desipramine group showed significantly better psychiatric status than the placebo group but did not differ from the placebo group on any of 21 other outcome measures, including cocaine use. During the 12-week medication phase and at the 1-month follow-up evaluation, urine toxicology screenings showed no significant difference between groups, but the placebo group had significantly less cocaine use at both the 3- and 6-month follow-up points. We conclude that desipramine has few benefits with regard to control of cocaine use in this population. JF - Archives of general psychiatry AU - Arndt, I O AU - Dorozynsky, L AU - Woody, G E AU - McLellan, A T AU - O'Brien, C P AD - Center for Studies of Addiction, Philadelphia, Veterans Administration Medical Center, PA 19104. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 888 EP - 893 VL - 49 IS - 11 SN - 0003-990X, 0003-990X KW - Placebos KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Desipramine KW - TG537D343B KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Drug Therapy, Combination KW - Double-Blind Method KW - Substance Abuse Detection KW - Humans KW - Patient Dropouts KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Comorbidity KW - Substance-Related Disorders -- diagnosis KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- complications KW - Desipramine -- therapeutic use KW - Cocaine -- urine KW - Substance-Related Disorders -- drug therapy KW - Opioid-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73349866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Desipramine+treatment+of+cocaine+dependence+in+methadone-maintained+patients.&rft.au=Arndt%2C+I+O%3BDorozynsky%2C+L%3BWoody%2C+G+E%3BMcLellan%2C+A+T%3BO%27Brien%2C+C+P&rft.aulast=Arndt&rft.aufirst=I&rft.date=1992-11-01&rft.volume=49&rft.issue=11&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-03 N1 - Date created - 1992-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats. AN - 73348476; 1443749 AB - Patients with diabetes may have peripheral neuropathy, which may have clinical implications for the use of regional nerve block. The effects of local anesthetics on nerve conduction and nerve fiber injury were tested in control rats and at 4 weeks after the onset of diabetes in rats injected with streptozotocin (50 mg/kg intraperitoneally). Nerve conduction was assessed by recording evoked electrical activity in hindpaw muscles following ipsilateral electrical stimulation of the sciatic nerve near the hip. Block of motor nerve conduction was quantified by recording the amplitude of the evoked response at 1-min intervals for up to 15 min after the injection of 500 microliters 1% lidocaine HCl or procaine HCl into the midthigh next to the sciatic nerve. In control animals, procaine was much less effective than lidocaine in producing conduction block. The rate and magnitude of lidocaine-induced conduction block were not significantly different between control and diabetic groups. However, conduction block due to procaine was sufficiently enhanced in diabetic rats to become comparable to that of lidocaine-treated control nerves. Long-lasting injury was assessed in sciatic nerve harvested 2 days after the extraneural injection of saline or 2 or 4% lidocaine HCl. Using a light microscope with a superimposed grid, nerve edema was quantified as the proportion of intersection points falling on extracellular space. Lidocaine induced edema in both control and diabetic nerves, but 4% lidocaine induced significantly more edema in diabetic nerves than in controls. Nerve fiber injury, based on light microscopic scoring of axonal degeneration and demyelination, was not observed in saline-treated nerves.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Anesthesiology AU - Kalichman, M W AU - Calcutt, N A AD - Department of Anesthesia, Veterans Administration Medical Center, San Diego, California 92161-9151. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 941 EP - 947 VL - 77 IS - 5 SN - 0003-3022, 0003-3022 KW - Procaine KW - 4Z8Y51M438 KW - Streptozocin KW - 5W494URQ81 KW - Lidocaine KW - 98PI200987 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Female KW - Neural Conduction -- physiology KW - Nerve Fibers -- physiology KW - Nerve Fibers -- drug effects KW - Neural Conduction -- drug effects KW - Procaine -- toxicity KW - Lidocaine -- toxicity KW - Diabetes Mellitus, Experimental -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73348476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Local+anesthetic-induced+conduction+block+and+nerve+fiber+injury+in+streptozotocin-diabetic+rats.&rft.au=Kalichman%2C+M+W%3BCalcutt%2C+N+A&rft.aulast=Kalichman&rft.aufirst=M&rft.date=1992-11-01&rft.volume=77&rft.issue=5&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-03 N1 - Date created - 1992-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Anesthesiology. 1993 Apr;78(4):799-800 [8466086] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Symptom reduction and sobriety in the male alcoholic. AN - 73344508; 1446963 AB - The relationship between subjective symptom reduction and sobriety was studied for 82 male alcoholics who had completed an inpatient Alcoholic Rehabilitation Unit that included six or more biofeedback/relaxation sessions. Specific symptom relief for anxiety was significantly correlated with sobriety. In addition, the reduction of symptoms showed a positive trend with sobriety. The discussion focuses on the relationship of anxiety-related symptoms and alcohol abuse. JF - The International journal of the addictions AU - Denney, M R AU - Baugh, J L AD - Veterans Administration Medical Center, Waco, Texas 76711. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1293 EP - 1300 VL - 27 IS - 11 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Biofeedback, Psychology KW - Behavior Therapy KW - Humans KW - Relaxation KW - Adult KW - Aged KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Alcoholism -- rehabilitation KW - Substance Withdrawal Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73344508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Symptom+reduction+and+sobriety+in+the+male+alcoholic.&rft.au=Denney%2C+M+R%3BBaugh%2C+J+L&rft.aulast=Denney&rft.aufirst=M&rft.date=1992-11-01&rft.volume=27&rft.issue=11&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-29 N1 - Date created - 1992-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extrapyramidal symptoms are serious side-effects of antipsychotic and other drugs. AN - 73320302; 1359485 AB - Antipsychotic medications commonly produce extrapyramidal symptoms as side effects. The extrapyramidal symptoms include acute dyskinesias and dystonic reactions, tardive dyskinesia, Parkinsonism, akinesia, akathisia, and neuroleptic malignant syndrome. Extrapyramidal symptoms are caused by dopamine blockade or depletion in the basal ganglia; this lack of dopamine often mimics idiopathic pathologies of the extrapyramidal system. Less recognized is that extrapyramidal symptoms are also associated with certain non-antipsychotic agents, including some antidepressants, lithium, various anticonvulsants, antiemetics and, rarely, oral-contraceptive agents. Extrapyramidal symptoms caused by these agents are indistinguishable from neuroleptic-induced extrapyramidal symptoms. Clinicians must be able to recognize these side effects and be able to determine the antipsychotic-induced and non-antipsychotic causes of extrapyramidal symptoms. JF - The Nurse practitioner AU - Blair, D T AU - Dauner, A AD - Colmery-O'Neil Veterans Administration Medical Center, Topeka, Kan. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 56 EP - 4, 67 VL - 17 IS - 11 SN - 0361-1817, 0361-1817 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Humans KW - Middle Aged KW - Male KW - Dyskinesia, Drug-Induced -- therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Dyskinesia, Drug-Induced -- physiopathology KW - Antipsychotic Agents -- adverse effects KW - Antipsychotic Agents -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73320302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Extrapyramidal+symptoms+are+serious+side-effects+of+antipsychotic+and+other+drugs.&rft.au=Blair%2C+D+T%3BDauner%2C+A&rft.aulast=Blair&rft.aufirst=D&rft.date=1992-11-01&rft.volume=17&rft.issue=11&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-23 N1 - Date created - 1992-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nurse Pract. 1993 Feb;18(2):13 [8096070] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. AN - 73306892; 1331172 AB - Escherichia coli endotoxin (LPS) can induce the clinical syndrome of septic shock and renal cortical necrosis and can stimulate nitric oxide (NO) production from macrophages, vascular smooth muscle, and glomerular mesangial cells in vitro. NO is an endogenous vasodilator, which also inhibits platelet aggregation and adhesion. We therefore sought to determine whether LPS would stimulate NO production in vivo and, if so, whether this NO would modulate endotoxin-induced glomerular thrombosis. The stable NO end-products, NO2 and NO3, were measured in serum and urine collections from rats during baseline and after injection of LPS, with or without substances that modulate NO synthesis. The urinary excretion of NO2/NO3 was 1,964 +/- 311 nm/8 h during the baseline and increased to 6,833 +/- 776 nm/8 h after a single intraperitoneal injection of 0.1 mg/kg LPS (P < 0.05). The serum concentration of NO2/NO3 also significantly increased after LPS injection. Both the urine and serum stimulation was significantly prevented by the NO synthesis inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME). L-Arginine, given with LPS+L-NAME significantly restored the NO2/NO3 levels in the urine. Ex vivo incubation of tissues from rats treated with LPS demonstrated NO production by the aorta, whole kidney, and glomeruli, but not cortical tubules. Histological examination of kidneys from rats given either LPS or L-NAME alone revealed that 2 and 4.5% of the glomeruli contained capillary thrombosis, respectively. In contrast, rats given LPS+L-NAME developed thrombosis in 55% of glomeruli (P < 0.001), which was significantly prevented when L-arginine was given concomitantly. We conclude that LPS stimulates endogenous production of NO in vivo and that this NO is critical in preventing LPS-induced renal thrombosis. JF - The Journal of clinical investigation AU - Shultz, P J AU - Raij, L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1718 EP - 1725 VL - 90 IS - 5 SN - 0021-9738, 0021-9738 KW - Lipopolysaccharides KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Cyclic GMP KW - H2D2X058MU KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Blood Pressure KW - Cyclic GMP -- urine KW - Arginine -- analogs & derivatives KW - Proteinuria -- etiology KW - Male KW - Arginine -- pharmacology KW - Thrombosis -- prevention & control KW - Thrombosis -- etiology KW - Nitric Oxide -- metabolism KW - Lipopolysaccharides -- toxicity KW - Kidney Glomerulus -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73306892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Endogenously+synthesized+nitric+oxide+prevents+endotoxin-induced+glomerular+thrombosis.&rft.au=Shultz%2C+P+J%3BRaij%2C+L&rft.aulast=Shultz&rft.aufirst=P&rft.date=1992-11-01&rft.volume=90&rft.issue=5&rft.spage=1718&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-22 N1 - Date created - 1992-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1991 Feb;87(2):602-8 [1671393] Kidney Int. 1977 Aug;12(2):91-5 [335145] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Hypertension. 1991 Jun;17(6 Pt 2):1045-51 [2045148] J Leukoc Biol. 1990 Dec;48(6):565-9 [2230601] J Clin Invest. 1990 Jan;85(1):264-73 [2404026] Annu Rev Pharmacol Toxicol. 1985;25:171-91 [2988418] Biochemistry. 1988 Nov 29;27(24):8706-11 [3242600] Proc Natl Acad Sci U S A. 1985 Nov;82(22):7738-42 [3906650] Thromb Diath Haemorrh Suppl. 1969;36:125-49 [5311135] Food Chem Toxicol. 1984 Jul;22(7):541-3 [6378739] J Clin Invest. 1992 Mar;89(3):867-77 [1541678] Am J Physiol. 1991 Oct;261(4 Pt 1):C634-41 [1656767] Lancet. 1991 Dec 21-28;338(8782-8783):1560-2 [1683976] Biochem Biophys Res Commun. 1990 Nov 15;172(3):1042-8 [1700903] Lancet. 1991 Dec 21-28;338(8782-8783):1557-8 [1720856] Ann Intern Med. 1991 Sep 15;115(6):457-69 [1872494] Am J Physiol. 1990 Jan;258(1 Pt 2):F162-7 [2154125] Am J Physiol. 1990 Mar;258(3 Pt 2):H655-62 [2156453] Proc Natl Acad Sci U S A. 1990 May;87(9):3629-32 [2333306] Biochem Biophys Res Commun. 1987 Nov 13;148(3):1482-9 [2825688] N Engl J Med. 1988 Jun 9;318(23):1481-6 [2835680] Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94 [3196352] Br J Pharmacol. 1987 Sep;92(1):181-7 [3311265] Am J Pathol. 1974 Apr;75(1):195-202 [4596652] Science. 1970 Nov 27;170(3961):986-8 [4920033] Kidney Int. 1984 Aug;26(2):137-43 [6239058] Anal Biochem. 1982 Oct;126(1):131-8 [7181105] Am J Physiol. 1991 Oct;261(4 Pt 2):F600-6 [1718166] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenomenology and course of psychiatric disorders associated with combat-related posttraumatic stress disorder. AN - 73288251; 1415826 AB - Studies indicate that chronic combat-related posttraumatic stress disorder (PTSD) is frequently associated with other psychiatric disorders. Questions regarding the nature and interrelationships of these conditions require clarification. The purpose of this study was to address primary and secondary illness relationships by focusing on the specific phenomenology and course of illness onset of PTSD comorbidity. In order to minimize confounding factors, only outpatients without recent substance use disorders were included. Sixty subjects who had been exposed to severe combat stress including veterans of Vietnam and veterans of World War II or Korea, 15 of whom were former prisoners of war, received structured assessments over serial evaluations. PTSD was the most prevalent lifetime disorder followed by major depression, panic disorder, generalized anxiety disorder, and phobic disorder or symptoms. Endogenous-appearing features overlapping other clinical populations were common; however, some specific symptom patterns also were suggestive of traumatic influence. Unlike generalized anxiety disorder and past substance use, the mean onset of phobias, major depression, and panic disorder, respectively, occurred later than PTSD. These observations suggest that persistent conditions related to PTSD progress toward symptoms that are increasingly autonomous in their pattern of occurrence. JF - The American journal of psychiatry AU - Mellman, T A AU - Randolph, C A AU - Brawman-Mintzer, O AU - Flores, L P AU - Milanes, F J AD - Miami Veterans Administration Medical Center, FL 33125. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1568 EP - 1574 VL - 149 IS - 11 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Age Factors KW - Depressive Disorder -- psychology KW - Humans KW - Veterans -- psychology KW - Retrospective Studies KW - Aged KW - Phobic Disorders -- epidemiology KW - Prisoners -- psychology KW - Comorbidity KW - Ambulatory Care KW - Depressive Disorder -- epidemiology KW - Phobic Disorders -- psychology KW - Adult KW - Depressive Disorder -- diagnosis KW - Anxiety Disorders -- epidemiology KW - Phobic Disorders -- diagnosis KW - Male KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Middle Aged KW - Female KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Mental Disorders -- diagnosis KW - Combat Disorders -- psychology KW - Mental Disorders -- epidemiology KW - Combat Disorders -- diagnosis KW - Mental Disorders -- psychology KW - Combat Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73288251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Phenomenology+and+course+of+psychiatric+disorders+associated+with+combat-related+posttraumatic+stress+disorder.&rft.au=Mellman%2C+T+A%3BRandolph%2C+C+A%3BBrawman-Mintzer%2C+O%3BFlores%2C+L+P%3BMilanes%2C+F+J&rft.aulast=Mellman&rft.aufirst=T&rft.date=1992-11-01&rft.volume=149&rft.issue=11&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-18 N1 - Date created - 1992-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells. AN - 73278392; 1330491 AB - Prostaglandin E2 (PGE2), PTH, and epidermal growth factor (EGF) are potent regulators of osteoblast proliferation. In UMR 106-01 rat osteosarcoma cells with osteoblast-like features, PGE2 and PTH inhibit, while EGF stimulates, mitogenesis. Both PGE2 and PTH increase intracellular cAMP levels, cytosolic calcium, and inositol phosphate turnover. In a variety of cell types, EGF mediates its effects in part via activation of receptor protein-tyrosine kinase and other protein kinases, such as protein kinase-C. The nuclear mechanisms of PGE2, PTH, and EGF regulation of osteoblast proliferation are unknown. Accordingly, we have examined the effects of these agents on mitogenesis, second messenger generation, and primary response genes, which may link second messenger activation to subsequent alterations in gene expression. Northern blot analysis of mRNA from UMR 106-01 cells treated for 3 h with 2 microM PGE2, 10 nM PTH, or 10 ng/ml EGF in the presence of cycloheximide demonstrated that all three agents induced the expression of c-fos and c-jun mRNA. In contrast, only EGF stimulated cellular proliferation and induced Egr-1 mRNA. Also, unlike PGE2 and PTH, EGF did not increase intracellular cAMP levels. c-fos mRNA was induced by treatment with 50 ng/ml tetradecanoyl phorbol acetate or by 40 ng/ml forskolin, while induction of Egr-1 mRNA was stimulated by treatment with tetradecanoyl phorbol acetate, but not forskolin. Thus, EGF signal transduction differs from that of PGE2 and PTH in UMR 106-01 osteoblast-like cells, in that EGF does not stimulate the protein kinase-A second messenger system, but causes activation of Egr-1, a primary response gene that may play a role in the mitogenic effect of EGF. JF - Endocrinology AU - Fang, M A AU - Kujubu, D A AU - Hahn, T J AD - Geriatric Research, Education, and Clinical Center, Wadsworth Veterans Administration Medical Center, Los Angeles, California 90073. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 2113 EP - 2119 VL - 131 IS - 5 SN - 0013-7227, 0013-7227 KW - Egr-1 KW - c-fos KW - c-jun KW - DNA-Binding Proteins KW - 0 KW - Early Growth Response Protein 1 KW - Egr1 protein, rat KW - Immediate-Early Proteins KW - Inositol Phosphates KW - Parathyroid Hormone KW - RNA, Messenger KW - Transcription Factors KW - Tritium KW - 10028-17-8 KW - Colforsin KW - 1F7A44V6OU KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cycloheximide KW - 98600C0908 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Protein Kinases -- physiology KW - Bone Neoplasms KW - Inositol Phosphates -- metabolism KW - Gene Expression Regulation, Neoplastic -- physiology KW - DNA-Binding Proteins -- genetics KW - RNA, Messenger -- genetics KW - Radioimmunoassay KW - Calcium -- metabolism KW - Rats KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured KW - Cycloheximide -- pharmacology KW - Enzyme Activation KW - RNA, Messenger -- analysis KW - Osteosarcoma KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Transcription Factors -- genetics KW - Thymidine -- metabolism KW - Protein Kinases -- metabolism KW - RNA, Messenger -- metabolism KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Zinc Fingers KW - Osteoblasts -- metabolism KW - Signal Transduction -- physiology KW - Parathyroid Hormone -- pharmacology KW - Osteoblasts -- physiology KW - Dinoprostone -- pharmacology KW - Signal Transduction -- drug effects KW - Mitosis -- drug effects KW - Genes, fos -- genetics KW - Epidermal Growth Factor -- pharmacology KW - Mitosis -- physiology KW - Genes, jun -- genetics KW - Osteoblasts -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73278392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+effects+of+prostaglandin+E2%2C+parathyroid+hormone%2C+and+epidermal+growth+factor+on+mitogenesis%2C+signaling%2C+and+primary+response+genes+in+UMR+106-01+osteoblast-like+cells.&rft.au=Fang%2C+M+A%3BKujubu%2C+D+A%3BHahn%2C+T+J&rft.aulast=Fang&rft.aufirst=M&rft.date=1992-11-01&rft.volume=131&rft.issue=5&rft.spage=2113&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-01 N1 - Date created - 1992-12-01 N1 - Date revised - 2017-01-13 N1 - Gene symbol - Egr-1; c-fos; c-jun N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol Use and High-Risk Behavior by Intravenous Drug Users in an AIDS Education Paradigm AN - 61308612; 9301791 AB - An experimental exploration of the relationship between alcohol consumption & high-risk behavior for human immunodeficiency virus (HIV) infection. Ss (N = 313 in-treatment intravenous drug users [IVDUs] in programs in Seattle, Wash) were randomly assigned to 1 of 3 interventions: (1) structured interview regarding risk behavior; (2) interview plus 1 group acquired immune deficiency syndrome (AIDS) education session; or (3) interview, AIDS education, & optional HIV testing. Alcohol users (N = 148) had more needle sharing & sexual partners than did nondrinkers. Follow-up interviews revealed no significant behavioral changes as a function of intervention condition or alcohol use. It is concluded that better interventions, particularly more vigorous treatment of alcohol use, are needed to reduce risk behaviors among IVDUs. 2 Tables, 3 Figures, 37 References. JF - Journal of Studies on Alcohol AU - Saxon, Andrew J AU - Calsyn, Donald A AD - Seattle Veterans Administration Medical Center, 1660 South Columbian Way Washington 98108 Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 611 EP - 618 VL - 53 IS - 6 SN - 0096-882X, 0096-882X KW - human immunodeficiency syndrome, risky alcohol/drug use/sexual behaviors, intravenous drug users KW - experimental data KW - treatment program, Seattle, Washington KW - Sexual Behavior KW - Risk KW - Educational Programs KW - Behavior Modification KW - Acquired Immune Deficiency Syndrome KW - Seattle, Washington KW - Alcohol Use KW - Drug Use KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61308612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Alcohol+Use+and+High-Risk+Behavior+by+Intravenous+Drug+Users+in+an+AIDS+Education+Paradigm&rft.au=Saxon%2C+Andrew+J%3BCalsyn%2C+Donald+A&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=1992-11-01&rft.volume=53&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Drug Use; Alcohol Use; Risk; Acquired Immune Deficiency Syndrome; Educational Programs; Seattle, Washington; Behavior Modification; Sexual Behavior ER - TY - JOUR T1 - Direct evidence for protein kinase C involvement in insulin-stimulated hexose uptake. AN - 73292692; 1417838 AB - Insulin has been reported to translocate protein kinase C (PKC) in rat adipocytes, and activation of PKC by phorbol esters is known to increase hexose uptake in these cells (1.2). To test the hypothesis that PKC may participate in insulin-stimulated hexose uptake, adipocytes were partially depleted of protein kinase C by overnight phorbol ester treatment, thereby impairing insulin effects on hexose uptake. Purified PKC was then introduced into these PKC-depleted adipocytes by electropermeabilization, and this fully restored insulin-stimulated hexose uptake. These findings provide direct evidence that PKC is required for insulin-stimulated hexose uptake. JF - Biochemical and biophysical research communications AU - Cooper, D R AU - Watson, J E AU - Hernandez, H AU - Yu, B AU - Standaert, M L AU - Ways, D K AU - Arnold, T T AU - Ishizuka, T AU - Farese, R V AD - Research Service, James A. Haley Veterans Administration Hospital, Tampa, FL 33612. Y1 - 1992/10/15/ PY - 1992 DA - 1992 Oct 15 SP - 142 EP - 148 VL - 188 IS - 1 SN - 0006-291X, 0006-291X KW - Monosaccharide Transport Proteins KW - 0 KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Rats KW - Animals KW - Glycerol -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Electric Stimulation KW - Male KW - Biological Transport -- drug effects KW - Protein Kinase C -- metabolism KW - Monosaccharide Transport Proteins -- metabolism KW - Adipose Tissue -- metabolism KW - Adipose Tissue -- drug effects KW - Deoxyglucose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73292692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Direct+evidence+for+protein+kinase+C+involvement+in+insulin-stimulated+hexose+uptake.&rft.au=Cooper%2C+D+R%3BWatson%2C+J+E%3BHernandez%2C+H%3BYu%2C+B%3BStandaert%2C+M+L%3BWays%2C+D+K%3BArnold%2C+T+T%3BIshizuka%2C+T%3BFarese%2C+R+V&rft.aulast=Cooper&rft.aufirst=D&rft.date=1992-10-15&rft.volume=188&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-19 N1 - Date created - 1992-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Auditory sensory gating and catecholamine metabolism in schizophrenic and normal subjects. AN - 85273811; pmid-1461944 AB - Diminished neuronal response to repeated sensory input is a sensory-gating phenomenon that has been found to be deficient in schizophrenic patients. For example, schizophrenic patients fail to decrease the amplitude of the P50 wave of the auditory evoked potential to the second of paired click stimuli. In some studies, however, normal subjects have also failed to decrease their P50 responses. The aim of this study was to determine if accommodation to the recording situation over time would affect the gating of the P50 response. The gating of the P50 wave is measured as the ratio of the amplitude of the second response to the amplitude of the first. Three successive auditory evoked potentials were compiled, each from trains of 32 pairs of stimuli. Twelve normal subjects and 12 schizophrenic patients were studied. Unconjugated catecholamine metabolites were measured from venous samples drawn before and after the electrophysiological recording. Between the first and third trials, the normal subjects significantly increased their gating of P50. This increase in gating of P50 was related to decreased levels of the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol. No similar phenomenon was observed in the schizophrenic patients, a number of whom had a further decrease in P50 gating over the three trials. Transient failure to observe gating of P50 in normal subjects may be related to increased state-dependent noradrenergic activity, which is known to disrupt sensory gating. This mechanism does not seem to account for the more persistent failure of sensory gating in schizophrenia. JF - Psychiatry Research AU - Waldo, M AU - Gerhardt, G AU - Baker, N AU - Drebing, C AU - Adler, L AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, CO. PY - 1992 SP - 21 EP - 32 VL - 44 IS - 1 SN - 0165-1781, 0165-1781 KW - Reference Values KW - Signal Processing, Computer-Assisted KW - Arousal KW - Auditory Pathways KW - Human KW - Electroencephalography KW - Neural Inhibition KW - Schizophrenia KW - Cerebral Cortex KW - Adult KW - Evoked Potentials, Auditory KW - Methoxyhydroxyphenylglycol KW - Acoustic Stimulation KW - Vanilmandelic Acid KW - Homovanillic Acid KW - Attention KW - Female KW - Schizophrenic Psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85273811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+Research&rft.atitle=Auditory+sensory+gating+and+catecholamine+metabolism+in+schizophrenic+and+normal+subjects.&rft.au=Waldo%2C+M%3BGerhardt%2C+G%3BBaker%2C+N%3BDrebing%2C+C%3BAdler%2C+L%3BFreedman%2C+R&rft.aulast=Waldo&rft.aufirst=M&rft.date=1992-10-01&rft.volume=44&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Psychiatry+Research&rft.issn=01651781&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. AN - 85257808; pmid-1450287 AB - Diminished gating of the P50 auditory evoked response to repeated stimuli is a psychophysiological feature of schizophrenia, that is also present in many relatives of patients. Animal models of auditory sensory gating indicate that nicotinic cholinergic neurotransmission is a critical neuronal substrate. The aim of this experiment was to determine if the deficit in sensory gating could be reversed by nicotine administration. Nonsmoking relatives of schizophrenics with abnormal sensory gating were selected as subjects for this initial double-blind trial, to avoid effects of psychotropic medications that might complicate trials in schizophrenic patients themselves. Nicotine-containing gum increased P50 sensory gating to near normal levels within 30 min of administration. The effect was transient; the gating of P50 returned to baseline levels within 1 hr. There was no change observed after placebo administration. In one of the subjects, the anticholinesterase inhibitor physostigmine similarly normalized P50 gating. The results are consistent with the hypothesis that nicotinic cholinergic neurotransmission may mediate a familial psychophysiological deficit in schizophrenia. JF - Biological Psychiatry AU - Adler, L E AU - Hoffer, L J AU - Griffith, J AU - Waldo, M C AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado. PY - 1992 SP - 607 EP - 616 VL - 32 IS - 7 SN - 0006-3223, 0006-3223 KW - Support, U.S. Gov't, P.H.S. KW - Signal Processing, Computer-Assisted KW - Double-Blind Method KW - Arousal KW - Chewing Gum KW - Human KW - Electroencephalography KW - Schizophrenia KW - Receptors, Nicotinic KW - Nicotine KW - Receptors, Muscarinic KW - Adult KW - Evoked Potentials, Auditory KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Physostigmine KW - Attention KW - Male KW - Female KW - Schizophrenic Psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85257808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Normalization+by+nicotine+of+deficient+auditory+sensory+gating+in+the+relatives+of+schizophrenics.&rft.au=Adler%2C+L+E%3BHoffer%2C+L+J%3BGriffith%2C+J%3BWaldo%2C+M+C%3BFreedman%2C+R&rft.aulast=Adler&rft.aufirst=L&rft.date=1992-10-01&rft.volume=32&rft.issue=7&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cryptococcal meningitis in patients with AIDS. AN - 73228447; 1402150 AB - In the U.S., cryptococcal meningitis is the most common form of fungal meningitis and a major cause of morbidity and mortality among immuno-suppressed patients. In the AIDS patient, cryptococcal meningitis often presents with fever and headache and is best treated with intravenous amphotericin B and oral flucytosine, or fluconazole. However, toxic effects may result from the therapy. This disease frequently relapses necessitating life-long treatment to prevent reactivation. Essential management principles focusing upon health education are presented to promote comprehensive nursing care for patients testing positive for the human immunodeficiency virus who also have cryptococcal meningitis. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Mocsny, N AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 265 EP - 268 VL - 24 IS - 5 SN - 0888-0395, 0888-0395 KW - Amphotericin B KW - 7XU7A7DROE KW - Fluconazole KW - 8VZV102JFY KW - Flucytosine KW - D83282DT06 KW - Index Medicus KW - Nursing KW - AIDS/HIV KW - Drug Therapy, Combination KW - Patient Education as Topic KW - Nursing Assessment KW - Fluconazole -- therapeutic use KW - Humans KW - Neurologic Examination KW - Amphotericin B -- therapeutic use KW - Flucytosine -- therapeutic use KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Meningitis, Cryptococcal -- drug therapy KW - Meningitis, Cryptococcal -- diagnosis KW - AIDS-Related Opportunistic Infections -- nursing KW - AIDS-Related Opportunistic Infections -- diagnosis KW - Meningitis, Cryptococcal -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73228447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Cryptococcal+meningitis+in+patients+with+AIDS.&rft.au=Mocsny%2C+N&rft.aulast=Mocsny&rft.aufirst=N&rft.date=1992-10-01&rft.volume=24&rft.issue=5&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-20 N1 - Date created - 1992-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics and implications of desflurane metabolism and toxicity. AN - 73187333; 1524235 AB - The metabolism of desflurane has been assessed both in animals and humans by measuring the appearance of fluoride metabolites (fluoride ion, nonvolatile organic fluoride, trifluoroacetic acid) in blood and urine. Desflurane administered to rats (either pretreated or not pretreated with phenobarbital or ethanol) for 3.2 MAC-hours and to swine for 5.5 MAC-hours produced fluoride ion levels in blood that were almost indistinguishable from values measured in control animals. In contrast, a significant 17% increase in plasma fluoride ion concentration in swine was detected 4 h after exposure to desflurane. In human studies, desflurane administered to patients (3.1 MAC-hours) and volunteers (7.35 MAC-hours) resulted in postanesthesia serum fluoride in concentrations that did not differ from background fluoride ion concentrations. Similarly, postanesthetic urinary excretion of fluoride ion and organic fluoride in volunteers was comparable to preanesthetic excretion rates. Small but statistically significant levels of trifluoroacetic acid were found in both serum and urine from volunteers after exposure to desflurane. Peak serum concentrations averaging 0.38 +/- 0.17 microM trifluoroacetic acid (mean +/- SD) and peak urinary excretion rates averaging 0.169 +/- 0.107 mumol/h were detected in volunteers 24 h after desflurane exposure. Although these increases in trifluoroacetic acid after exposure to desflurane were statistically significant, they are approximately 10-fold less than levels seen after exposure to isoflurane. Desflurane strongly resists biodegradation, and only a small amount is metabolized in animals and humans. JF - Anesthesia and analgesia AU - Koblin, D D AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - S10 EP - S16 VL - 75 IS - 4 Suppl SN - 0003-2999, 0003-2999 KW - Anesthetics KW - 0 KW - desflurane KW - CRS35BZ94Q KW - Isoflurane KW - CYS9AKD70P KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Anesthetics -- toxicity KW - Isoflurane -- toxicity KW - Isoflurane -- metabolism KW - Isoflurane -- adverse effects KW - Anesthetics -- adverse effects KW - Anesthesia, Inhalation KW - Anesthetics -- metabolism KW - Isoflurane -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73187333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Characteristics+and+implications+of+desflurane+metabolism+and+toxicity.&rft.au=Koblin%2C+D+D&rft.aulast=Koblin&rft.aufirst=D&rft.date=1992-10-01&rft.volume=75&rft.issue=4+Suppl&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-15 N1 - Date created - 1992-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role for protein synthesis in the neurotoxic effects of methamphetamine in mice and rats. AN - 73335923; 1446227 AB - The mechanism by which the amphetamines damage selectively nigrostriatal dopaminergic neurons in experimental animals remains uncertain. The observation that neuronal cell death during embryogenesis involves an activation of gene expression and new protein synthesis, coupled with recent reports indicating that the amphetamines are capable of inducing neuropeptide biosynthesis, offers a possible clue as to their neurotoxic mechanism of action. Based on these considerations, we evaluated the effects of two different inhibitors of protein synthesis, cycloheximide and anisomycin, on the long-term, amine-depleting effects of methamphetamine (METH) in mice and rats. Both inhibitors were found to block the amine-depleting effects of METH in these species. In other experiments, cycloheximide did not affect the functional integrity of dopaminergic or glutamatergic neurons, transmitter systems previously implicated in the neurotoxic mechanism of action of METH. These findings raise the possibility that the neuronal-damaging effects of METH are mediated via a synthesis of 'neurotoxic' proteins. JF - Brain research AU - Finnegan, K T AU - Karler, R AD - Psychiatry Service, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1992/09/18/ PY - 1992 DA - 1992 Sep 18 SP - 160 EP - 164 VL - 591 IS - 1 SN - 0006-8993, 0006-8993 KW - Nerve Tissue Proteins KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Anisomycin KW - 6C74YM2NGI KW - Cycloheximide KW - 98600C0908 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Mice KW - Male KW - Cycloheximide -- pharmacology KW - Brain -- drug effects KW - Dopamine -- metabolism KW - Nerve Tissue Proteins -- biosynthesis KW - Anisomycin -- pharmacology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73335923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Role+for+protein+synthesis+in+the+neurotoxic+effects+of+methamphetamine+in+mice+and+rats.&rft.au=Finnegan%2C+K+T%3BKarler%2C+R&rft.aulast=Finnegan&rft.aufirst=K&rft.date=1992-09-18&rft.volume=591&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-30 N1 - Date created - 1992-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prediction of Helicobacter pylori in gastric specimens by inflammatory and morphological histological evaluation. AN - 85226246; pmid-1519569 AB - Statistical correlations and predictive values were calculated for 330 gastrointestinal biopsies and tissues, of which 248 were from the stomach from 115 patients in this retrospective study, which graded 10 inflammatory and 14 morphological mucosal and submucosal abnormalities and compared them with the presence of Helicobacter pylori. Analysis revealed that 78 (31.5%) of the 248 stomach biopsies and tissues showed H. pylori, and 21 (8.5%) had non-Helicobacter-like bacteria, such as rods and cocci. Inflammatory components had high correlations, with specimens containing polymorphonuclear leukocytes (PMNs) showing high specificities and predictive values for a positive test, whereas the chronic inflammatory components had high sensitivities and predictive values for a negative test. Positive morphological correlations existed for mucus depletion, degeneration, regeneration, and ulceration, but intestinal metaplasia and adenocarcinoma had negative correlations. The antrum was most commonly infected, suggesting that intact healthy antral morphology and the neutral mucin in the surface epithelial cells represents the optimal environment for infection. Also, 8.5% of the gastric biopsies and tissues showed non-Helicobacter bacteria associated with inflammation, thus raising the question of colonization versus pathogenesis. JF - The American Journal of Gastroenterology AU - Hansing, R L AU - D'Amico, H AU - Levy, M AU - Guillan, R A AD - Department of Pathology and Surgery, Colmery-O'Neil Veterans Administration Hospital, Topeka, Kansas. PY - 1992 SP - 1125 EP - 1131 VL - 87 IS - 9 SN - 0002-9270, 0002-9270 KW - Helicobacter pylori KW - Human KW - Retrospective Studies KW - Aged KW - Predictive Value of Tests KW - Gastrointestinal System KW - Neutrophils KW - Aged, 80 and over KW - Adult KW - Mucous Membrane KW - Middle Age KW - Gastroenteritis KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Prediction+of+Helicobacter+pylori+in+gastric+specimens+by+inflammatory+and+morphological+histological+evaluation.&rft.au=Hansing%2C+R+L%3BD%27Amico%2C+H%3BLevy%2C+M%3BGuillan%2C+R+A&rft.aulast=Hansing&rft.aufirst=R&rft.date=1992-09-01&rft.volume=87&rft.issue=9&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanism and role of insulin receptor endocytosis. AN - 73431971; 1476159 AB - Like many other cell surface receptors for nutrients and polypeptide hormones, the insulin receptor undergoes a complex endocytotic itinerary. Upon insulin binding, the receptor is activated as a tyrosine-specific protein kinase and autophosphorylates. This autophosphorylation is necessary for the receptor to internalize. After endocytosis, the ligand (insulin) and its receptor are dissociated. Most of the insulin is degraded, whereas the receptors are largely recycled to the cell surface. The signals in the receptor that control and specify its endocytotic pathway are beginning to be understood. Through the techniques of in vitro mutagenesis, noninternalizing receptors have been engineered and their structural and functional properties have been analyzed. For example, the immediate submembranous domain of the insulin receptor has been found to contain sequences (Gly-Pro-Leu-Tyr and, to a lesser extent, Asn-Pro-Gln-Tyr) that are necessary for normal endocytosis. Receptors deleted or mutated in these sequences retain tyrosine kinase activity but fail to undergo endocytosis. Unlike the better understood low density lipoprotein and transferrin receptors, however, these sequences are not sufficient for endocytosis. An insulin receptor with only these sequences exposed in the cytoplasm does not internalize. Tyrosine kinase activity is thought to be needed to lead to autophosphorylation and a conformational change that exposes the otherwise buried endocytosis sequences in the normally dimerized insulin receptor. Non-internalizing mutants of the insulin receptor have been used to examine the role of endocytosis in insulin action. It was found that an endocytosis-defective receptor could induce a short-term metabolic action of insulin (glycogen synthetase stimulation) as well as longer-term mitogenic effects of insulin. Furthermore, insulin action deactivated after the hormone was removed from the noninternalizing receptors. Apparently, endocytosis is not necessary for insulin action, but probably is important for removing the insulin from the cell so the target cell for insulin responds in a time-limited fashion to the hormone. JF - The American journal of the medical sciences AU - McClain, D A AD - Veterans Administration Medical Center, Birmingham, Alabama 35213. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 192 EP - 201 VL - 304 IS - 3 SN - 0002-9629, 0002-9629 KW - Recombinant Proteins KW - 0 KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Down-Regulation KW - Transfection KW - Recombinant Proteins -- metabolism KW - Exons KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cell Line KW - Mutagenesis KW - Endocytosis KW - Receptor, Insulin -- genetics KW - Receptor, Insulin -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73431971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Mechanism+and+role+of+insulin+receptor+endocytosis.&rft.au=McClain%2C+D+A&rft.aulast=McClain&rft.aufirst=D&rft.date=1992-09-01&rft.volume=304&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-02 N1 - Date created - 1993-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital. AN - 73286906; 1409808 AB - Recent reports have indicated that the neurosteroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) interact with the GABAA receptor complex. Because many of the behavioral effects of ethanol and pentobarbital are due to activity at this complex, DHEA and DHEAS were tested for their ability to interact with the hypnotic and hypothermic effects of ethanol and pentobarbital. DHEA, but not DHEAS, causes a dose-dependent increase in the sleep time induced by either ethanol or pentobarbital. At 20 mg/kg, DHEA and DHEAS themselves cause a fall in body temperature. DHEA enhances the hypothermic effect of both ethanol and pentobarbital. DHEAS enhances the hypothermic effect of ethanol, but with pentobarbital it only delays the return of body temperature to baseline levels. Neither DHEA nor DHEAS affects the metabolism of ethanol. JF - Pharmacology, biochemistry, and behavior AU - Melchior, C L AU - Ritzmann, R F AD - Brentwood Division Research, West Los Angeles Veterans Administration, CA 90073. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 223 EP - 227 VL - 43 IS - 1 SN - 0091-3057, 0091-3057 KW - Hypnotics and Sedatives KW - 0 KW - Ethanol KW - 3K9958V90M KW - Dehydroepiandrosterone KW - 459AG36T1B KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Sleep -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - gamma-Aminobutyric Acid -- metabolism KW - Drug Synergism KW - Ethanol -- blood KW - Body Temperature -- drug effects KW - Ethanol -- pharmacology KW - Dehydroepiandrosterone -- pharmacology KW - Hypnotics and Sedatives -- pharmacology KW - Pentobarbital -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73286906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Dehydroepiandrosterone+enhances+the+hypnotic+and+hypothermic+effects+of+ethanol+and+pentobarbital.&rft.au=Melchior%2C+C+L%3BRitzmann%2C+R+F&rft.aulast=Melchior&rft.aufirst=C&rft.date=1992-09-01&rft.volume=43&rft.issue=1&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-02 N1 - Date created - 1992-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mental Health Status and Community Adjustment after Treatment in a Residential Treatment Program for Homeless Veterans AN - 61622841; 199301431 AB - To examine the relationship among psychiatric & substance abuse problems, community adjustment, & housing status in a sample of 255 homeless veterans, interview data were collected following treatment at programs in Fla, Ohio, & Calif. Program participation is found to be associated with improvement in all areas of mental health. However, this improvement is only weakly linked to improvement in other areas. 4 Tables, 16 References. E. Mortenson JF - The American Journal of Psychiatry AU - Leda, Catherine AU - Rosenheck, Robert AD - Northeast Program Evaluation Center West Haven Veterans Administration Medical Center, 950 Campbell Ave CT 06516 Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 1219 EP - 1224 VL - 149 IS - 9 SN - 0002-953X, 0002-953X KW - mental health status/community adjustment, postresidential treatment, homeless veterans KW - interviews KW - Florida/Ohio/California KW - Veterans KW - Treatment Outcomes KW - Substance Abuse KW - Residential Institutions KW - Mental Health KW - Mental Illness KW - Adjustment KW - Homelessness KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61622841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Mental+Health+Status+and+Community+Adjustment+after+Treatment+in+a+Residential+Treatment+Program+for+Homeless+Veterans&rft.au=Leda%2C+Catherine%3BRosenheck%2C+Robert&rft.aulast=Leda&rft.aufirst=Catherine&rft.date=1992-09-01&rft.volume=149&rft.issue=9&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Outcomes; Veterans; Homelessness; Adjustment; Mental Health; Substance Abuse; Mental Illness; Residential Institutions ER - TY - JOUR T1 - Cholinergic denervation alters [3H]phorbol-12,13-dibutyrate binding to rat hippocampal membranes. AN - 73173727; 1525667 AB - Cholinergic denervation of the rat hippocampus caused by electrolytic lesions of the medial septum (MS) results in a time-bound ingrowth of peripheral sympathetic noradrenergic fibers from the superior cervical ganglion to the dentate gyrus and CA3 region of the hippocampus. To determine the functional significance of hippocampal sympathetic ingrowth (HSI), [3H]phorbol-12,13-dibutyrate (PDBu) binding was assessed 4 weeks after MS lesions. In control animals, affinity for [3H]PDBu binding was found to be greater in the dorsal compared to ventral hippocampus, while the number of binding sites (Bmax) was similar between regions. Regardless of the presence of HSI, MS lesions resulted in increased affinity in the dorsal hippocampus, while the Bmax was found to 'normalize' in the ventral hippocampus by HSI. These results suggest that HSI is functional and can alter important cellular events. JF - Brain research AU - Ayyagari, V AU - Harrell, L E AD - Behavioral Neuroscience Program, Veterans Administration, Birmingham, AL. Y1 - 1992/08/07/ PY - 1992 DA - 1992 Aug 07 SP - 343 EP - 347 VL - 587 IS - 2 SN - 0006-8993, 0006-8993 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Ganglia, Parasympathetic -- cytology KW - Signal Transduction -- drug effects KW - In Vitro Techniques KW - Membranes -- metabolism KW - Ganglia, Parasympathetic -- metabolism KW - Denervation KW - Male KW - Parasympathetic Nervous System -- physiology KW - Hippocampus -- metabolism KW - Phorbol 12,13-Dibutyrate -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73173727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Cholinergic+denervation+alters+%5B3H%5Dphorbol-12%2C13-dibutyrate+binding+to+rat+hippocampal+membranes.&rft.au=Ayyagari%2C+V%3BHarrell%2C+L+E&rft.aulast=Ayyagari&rft.aufirst=V&rft.date=1992-08-07&rft.volume=587&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Production of both 92- and 72-kDa gelatinases by bone cells. AN - 73328281; 1435512 AB - We investigated the ability of murine bone organ cultures and osteoblast-like bone cells to produce 72- and 92-kDa gelatinase. 4-6 day newborn mouse calvaria cultures were found to release gelatinase activity into their conditioned medium (CM). This activity was increased by four stimulators of resorption, tumor necrosis factor alpha (TNF), interleukin-1 alpha (IL-1), parathyroid hormone (PTH) and the active phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). Both the 72- and 92-kDa forms of gelatinase were produced by murine bone cultures. In unstimulated bones 72-kDa gelatinase activity was approximately equal to that of the 92-kDa enzyme. IL-1, TNF, PTH and TPA all increased 92-kDa gelatinase activity in the CM of the bone cultures by about 2- to 2.5-fold. In addition TPA and IL-1 also increased 72-kDa gelatinase activity. In unstimulated osteoblast-like MC3T3-E1 cell cultures 72-kDa gelatinase enzyme activity was much greater than 92-kDa activity and was not substantially regulated (less than 40% change) by IL-1, TNF or PTH. In contrast, these agents stimulated 92-kDa gelatinase activity by 2- to 5-fold. As with the MC3T3-E1 cells, primary cells constitutively produced both 72-kDa and 92-kDa gelatinase. This was true for cells with both the most differentiated osteoblast-like phenotype (populations 3 and 4) and the least osteoblast-like phenotype (populations 1 and 2). In unstimulated cultures of all 4-primary populations, 92-kDa gelatinase production was less than 72-kDa and IL-1, TNF and PTH had only small effects on 72-kDa production in any of the populations (less than 60% change).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Matrix (Stuttgart, Germany) AU - Lorenzo, J A AU - Pilbeam, C C AU - Kalinowski, J F AU - Hibbs, M S AD - Department of Medicine, Veterans Administration Medical Center, Newington, CT 06111. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 282 EP - 290 VL - 12 IS - 4 SN - 0934-8832, 0934-8832 KW - Interleukin-1 KW - 0 KW - Matrix Metalloproteinase Inhibitors KW - Parathyroid Hormone KW - Tumor Necrosis Factor-alpha KW - Collagenases KW - EC 3.4.24.- KW - Metalloendopeptidases KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Interleukin-1 -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Mice KW - Skull -- cytology KW - Animals, Newborn KW - Parathyroid Hormone -- pharmacology KW - Skull -- enzymology KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Organ Culture Techniques KW - Osteoblasts -- drug effects KW - Osteoblasts -- enzymology KW - Bone and Bones -- enzymology KW - Collagenases -- biosynthesis KW - Metalloendopeptidases -- antagonists & inhibitors KW - Metalloendopeptidases -- biosynthesis KW - Bone and Bones -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73328281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Matrix+%28Stuttgart%2C+Germany%29&rft.atitle=Production+of+both+92-+and+72-kDa+gelatinases+by+bone+cells.&rft.au=Lorenzo%2C+J+A%3BPilbeam%2C+C+C%3BKalinowski%2C+J+F%3BHibbs%2C+M+S&rft.aulast=Lorenzo&rft.aufirst=J&rft.date=1992-08-01&rft.volume=12&rft.issue=4&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Matrix+%28Stuttgart%2C+Germany%29&rft.issn=09348832&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-02 N1 - Date created - 1992-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital. AN - 73158453; 1513842 AB - 3-alpha-Hydroxy-5-beta-pregnan-20-one [pregnanolone (PA)] and 3-beta-hydroxy-5-pregnen-20-one 3-sulfate [pregnenolone sulfate (PS)] are steroids that have been shown in biochemical studies to be active at the GABA-benzodiazepine-chloride receptor complex, Pa as a "barbiturate-like" agonist and PS as a "picrotoxin-like" antagonist. Since other compounds that are active at this site interact with the effects of pentobarbital and ethanol, the behavioral effects of these steroids alone and in combination with pentobarbital and ethanol were tested. Pa blocks the convulsions caused by pentylenetetrazole (PTZ) and increases motor activity when given alone in low doses. In combination with either pentobarbital or ethanol, it enhances the depression in motor activity, hypothermia, and hypnosis. In contrast, PS has no effect on PTZ convulsions and depresses motor activity by itself. With pentobarbital, PS enhances the depression in motor activity but has no effect on hypothermia or hypnosis. With ethanol, PS enhances the hypothermia but does not affect motor activity or hypnosis. Therefore, Pa and PS show different but not opposite effects in interacting with compounds active at the GABA-benzodiazepine-chloride receptor complex. JF - Pharmacology, biochemistry, and behavior AU - Melchior, C L AU - Allen, P M AD - Brentwood Research Service, West Los Angeles Veterans Administration Medical Center, CA 90073. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 605 EP - 611 VL - 42 IS - 4 SN - 0091-3057, 0091-3057 KW - Ethanol KW - 3K9958V90M KW - Pregnenolone KW - 73R90F7MQ8 KW - Pregnanolone KW - BXO86P3XXW KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Sleep -- drug effects KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Motor Activity -- drug effects KW - Mice KW - Seizures -- prevention & control KW - Time Factors KW - Male KW - Pregnenolone -- pharmacology KW - Ethanol -- pharmacology KW - Pregnanolone -- pharmacology KW - Pentobarbital -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73158453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Interaction+of+pregnanolone+and+pregnenolone+sulfate+with+ethanol+and+pentobarbital.&rft.au=Melchior%2C+C+L%3BAllen%2C+P+M&rft.aulast=Melchior&rft.aufirst=C&rft.date=1992-08-01&rft.volume=42&rft.issue=4&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-25 N1 - Date created - 1992-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aging of FRTL-5 rat thyroid cells causes sensitivity to cytotoxicity induced by tumor necrosis factor-alpha. AN - 73083878; 1322286 AB - While investigating the modulation of the growth and function of the FRTL-5 rat thyroid cell line by recombinant human tumor necrosis factor-alpha (TNF alpha), we noticed that pronounced changes in several response parameters occurred with increasing passage number. For young cells (passage less than 20), TNF alpha by itself slightly increased [3H]thymidine incorporation and DNA content, and had a minimal effect on basal 125I uptake. When combined with TSH, TNF alpha had no influence on TSH-stimulated [3H]thymidine incorporation, but significantly inhibited TSH-stimulated 125I uptake. Compared with young cells, aged cells (passage greater than 40), in contrast, developed a high sensitivity to TNF alpha. TNF alpha markedly stimulated [3H]thymidine incorporation into DNA, inhibited TSH-stimulated 125I uptake per micrograms DNA, but dramatically decreased the total DNA content and cell number. TSH augmented the TNF alpha effect in aged cells, resulting in a further reduction of DNA content. Aphidicolin, a specific inhibitor of DNA polymerase-alpha which is associated with DNA replication, dramatically inhibited TNF alpha-induced [3H]thymidine incorporation in both young and aged cells; this suggested that the effect of TNF alpha on FRTL-5 cell growth is related to DNA replication, rather than DNA repair. 51Cr release from FRTL-5 cells, a measure of cytotoxicity, increased 2-fold over baseline in aged cells at a dose of 400 ng/ml TNF alpha and decreased to 70% of baseline in young cells at this same dose. The protein kinase-A (PKA) and protein kinase-C (PKC) signal transduction mechanisms of TNF alpha in aged cells (passage greater than 40) were also studied. TNF alpha increased cAMP and also increased relative PKA and PKC activity in 1-40 min. Phorbol myristate acetate (PMA), an activator of PKC, increased [3H]thymidine incorporation and DNA content. PMA did not affect the TNF alpha-induced increase in [3H]thymidine incorporation or its reduction of DNA content. When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC. We conclude that the sensitivity of FRTL-5 cells to the cytotoxic effect of TNF alpha increases with aging. JF - Endocrinology AU - Chen, G AU - Pekary, A E AU - Hershman, J M AD - Endocrinology Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 863 EP - 870 VL - 131 IS - 2 SN - 0013-7227, 0013-7227 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Aphidicolin KW - 38966-21-1 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Protein Kinase C -- metabolism KW - Protein Kinases -- metabolism KW - Aphidicolin -- pharmacology KW - Animals KW - Thyrotropin -- pharmacology KW - Humans KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - DNA -- biosynthesis KW - DNA Replication -- drug effects KW - Cell Line KW - Thyroid Gland -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Cell Aging -- physiology KW - Thyroid Gland -- cytology KW - Cell Survival -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73083878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Aging+of+FRTL-5+rat+thyroid+cells+causes+sensitivity+to+cytotoxicity+induced+by+tumor+necrosis+factor-alpha.&rft.au=Chen%2C+G%3BPekary%2C+A+E%3BHershman%2C+J+M&rft.aulast=Chen&rft.aufirst=G&rft.date=1992-08-01&rft.volume=131&rft.issue=2&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-02 N1 - Date created - 1992-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction. AN - 73071448; 1322272 AB - We studied the role of the carboxyl-terminus of the extracellular region of the human TSH receptor in signal transduction (cAMP generation). For this purpose, we introduced homologous substitutions of smaller segments within amino acids 261-418 (domains D and E) of the TSH receptor with the corresponding amino acids of the rat LH/CG receptor. Amino acids 317-366 were not investigated in view of previous data indicating their noninvolvement. Mutant TSH receptor cDNAs, in a eukaryotic expression vector, were stably transfected into Chinese hamster ovary cells. Eight of nine plasmid constructs expressed TSH receptors that could be detected by radiolabeled TSH binding; six of these were of high affinity similar to the wild-type receptor and, therefore, provided informative data on signal transduction. Despite high affinity TSH binding, five of six TSH receptor mutants displayed a diminished cAMP response to TSH stimulation, suggesting the involvement of broad segments of domains DE in signal transduction. Amino acids 270-278 and 287-297 were particularly important in this respect. The conformation conferred by these segments of the TSH receptor, therefore, appears to be involved in transducing a signal from the extracellular to the intracellular region of the receptor. JF - Endocrinology AU - Nagayama, Y AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 548 EP - 552 VL - 131 IS - 2 SN - 0013-7227, 0013-7227 KW - Autoantibodies KW - 0 KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cyclic AMP -- biosynthesis KW - Humans KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Rats KW - Transfection KW - Molecular Sequence Data KW - CHO Cells KW - Thyrotropin -- metabolism KW - Graves Disease -- immunology KW - Cricetinae KW - Signal Transduction -- physiology KW - Receptors, Thyrotropin -- chemistry KW - Receptors, Thyrotropin -- physiology KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73071448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Role+of+the+carboxyl-terminal+half+of+the+extracellular+domain+of+the+human+thyrotropin+receptor+in+signal+transduction.&rft.au=Nagayama%2C+Y%3BRapoport%2C+B&rft.aulast=Nagayama&rft.aufirst=Y&rft.date=1992-08-01&rft.volume=131&rft.issue=2&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-02 N1 - Date created - 1992-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spectrum of injury produced in the duodenum by perfusion with luminal acid in the rat. AN - 73056449; 1634066 AB - The dose and time dependence of duodenal mucosal injury by luminal acid perfusion was studied. Saline, 0.01, 0.05, 0.15, and 0.3N HCl, were perfused through the proximal duodena of rats for 5, 15, or 30 minutes and then harvested for histological examination. In a second set of studies, after a 30-minute perfusion, duodena were harvested either immediately or 2, 4, 8, or 24 hours after the perfusion to study the recovery from injury. Acid disappearance (acid delivered minus acid recovered) was measured in all groups. Duodena were examined grossly, then fixed, stained, and scored histologically. Whereas no gross mucosal injury was noted, there was graded histological injury proportional to acid concentration. Injury occurred early in the perfusion and changed little with increased perfusion durations. The initial injury lead to an acid disappearance rate that was proportional to acid concentration and, therefore, the degree of injury. After the initial injury occurred, the rate of acid neutralization was unchanged by increased duration of acid perfusion. This acid neutralization protected against further injury despite the continued presence of acid. Recovery from injury was complete with physiological (0.01 and 0.05N HCl) but not pharmacological (0.15 and 0.3N HCl) concentrations of acid. It is concluded that acid-induced duodenal injury occurs within 5 minutes of exposure, is proportional to the acid concentration, and results in acid neutralization that protects against extension of the injury with continued acid exposure. JF - Gastroenterology AU - Livingston, E H AU - Passaro, E P AU - Miller, J AU - Guth, P H AD - Surgical Service, West Los Angeles Veterans Administration Medical Center, California. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 481 EP - 489 VL - 103 IS - 2 SN - 0016-5085, 0016-5085 KW - Hydrochloric Acid KW - QTT17582CB KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Male KW - Duodenum -- drug effects KW - Hydrochloric Acid -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73056449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Spectrum+of+injury+produced+in+the+duodenum+by+perfusion+with+luminal+acid+in+the+rat.&rft.au=Livingston%2C+E+H%3BPassaro%2C+E+P%3BMiller%2C+J%3BGuth%2C+P+H&rft.aulast=Livingston&rft.aufirst=E&rft.date=1992-08-01&rft.volume=103&rft.issue=2&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-25 N1 - Date created - 1992-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Psychotherapist as Witness for the Prosecution: The Criminalization of Tarasoff AN - 61302154; 93Z8203 AB - The California Supreme Court decision in 1976 in Tarasoff v. Regents of the University of California established the "duty to protect" doctrine, obligating mental health professionals to disclose information about their clients if they thought a third party might be in danger. In another case, a court deemed that certain clinical sessions were not psychotheraphy, & hence not confidential. Analyzed here are three cases in which mental health professionals served as prosecution witnesses, violating psychotherapist-patient privilege. The harmful effects of the erosion of confidentiality are indicated, eg, threat to professionals, & professionals' refraining from treating difficult patients. 21 References. I. Shagrir JF - The American Journal of Psychiatry AU - Leong, Gregory B AU - Eth, Spencer AU - Silva, J Arturo AD - West Los Angeles Veterans Administration Medical Center, 11301 Wilshire Blvd CA 90073 Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 1011 EP - 1015 VL - 149 IS - 8 SN - 0002-953X, 0002-953X KW - psychotherapist as prosecution witness, patient confidentiality issues KW - court cases KW - Therapists KW - Psychotherapy KW - Psychologists KW - Confidentiality KW - Judicial Decisions KW - Witnesses KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) KW - 1636: social control; sociology of law UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61302154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=The+Psychotherapist+as+Witness+for+the+Prosecution%3A+The+Criminalization+of+Tarasoff&rft.au=Leong%2C+Gregory+B%3BEth%2C+Spencer%3BSilva%2C+J+Arturo&rft.aulast=Leong&rft.aufirst=Gregory&rft.date=1992-08-01&rft.volume=149&rft.issue=8&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Confidentiality; Judicial Decisions; Psychologists; Therapists; Witnesses; Psychotherapy ER - TY - JOUR T1 - Chronic sodium azide treatment impairs learning of the Morris water maze task. AN - 73299595; 1417674 AB - A reduction in the activity of cytochrome oxidase, a respiratory chain enzyme, has been recently identified in mitochondria from blood platelets and postmortem brain tissue from Alzheimer's disease (AD) patients. We have developed an animal model of this deficit in rats by chronic subcutaneous infusion of sodium azide, a selective inhibitor of cytochrome oxidase, delivered via Alzet 2ML4 osmotic minipumps. In previous work, azide-treated rats were impaired in an appetitively motivated spatial learning task, the radial arm maze. In the present investigation, we tested male Sprague-Dawley rats (350-400 g), which were tonically infused with azide or saline, on an aversively motivated spatial task, the Morris water maze. Azide-treated rats were impaired on both acquisition and retention of this task, without showing evidence of a motor impairment. Thus, the present results are consistent with previous findings showing that chronic azide treatment produces a learning and memory deficit. These findings strengthen the hypothesis that azide treatment in rats produces a useful animal model of some aspects of AD. JF - Behavioral and neural biology AU - Bennett, M C AU - Rose, G M AD - Medical Research Service, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 72 EP - 75 VL - 58 IS - 1 SN - 0163-1047, 0163-1047 KW - Azides KW - 0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Space Perception -- drug effects KW - Injections, Subcutaneous KW - Retention (Psychology) -- drug effects KW - Learning -- drug effects KW - Male KW - Azides -- metabolism KW - Memory Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73299595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+neural+biology&rft.atitle=Chronic+sodium+azide+treatment+impairs+learning+of+the+Morris+water+maze+task.&rft.au=Bennett%2C+M+C%3BRose%2C+G+M&rft.aulast=Bennett&rft.aufirst=M&rft.date=1992-07-01&rft.volume=58&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+neural+biology&rft.issn=01631047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-04 N1 - Date created - 1992-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The potentiation of narcotic analgesics with phenothiazines. AN - 73229325; 1357024 AB - Potentiation of narcotic analgesics with phenothiazines have been used for preoperative and postoperative analgesia for a number of years by the podiatric community. The agents most frequently cited in studies are the combination of meperidine with either the phenothiazines chlorpromazine, trimeprazine, or promethazine. Due to the fact that the double-blind clinical studies of pain are mainly subjective, and difficult to quantify, the usefulness of phenothiazines for the sole purpose of potentiation of analgesia is questionable, especially in view of the many side effects of this group of drugs. JF - The Journal of foot surgery AU - Richter, P A AU - Burk, M P AD - James A. Haley Veterans Administration Hospital Podiatric Residency Program, Tampa, Florida. PY - 1992 SP - 378 EP - 380 VL - 31 IS - 4 SN - 0449-2544, 0449-2544 KW - Analgesics, Opioid KW - 0 KW - Phenothiazines KW - Meperidine KW - 9E338QE28F KW - Index Medicus KW - Meperidine -- pharmacology KW - Humans KW - Drug Synergism KW - Phenothiazines -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Phenothiazines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73229325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+foot+surgery&rft.atitle=The+potentiation+of+narcotic+analgesics+with+phenothiazines.&rft.au=Richter%2C+P+A%3BBurk%2C+M+P&rft.aulast=Richter&rft.aufirst=P&rft.date=1992-07-01&rft.volume=31&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+foot+surgery&rft.issn=04492544&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-03 N1 - Date created - 1992-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells. AN - 73014096; 1612026 AB - Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells. In the present work we studied the mechanism of TGF beta action in FRTL-5 rat thyroid cells. The cells were treated with TGF beta in the presence of TSH, growth factors, and cellular modulators for various periods of time; then, [3H]thymidine incorporation and DNA content were measured as indicators of DNA synthesis, and [125I]iodide uptake was measured to assess cell function. TGF beta (10 ng/ml) inhibited TSH-induced DNA synthesis and iodide uptake. TGF beta also inhibited DNA synthesis induced by insulin-like growth factor-I, fibroblast growth factor, and endothelial cell growth factor. The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation. The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate. The results show that activation of PKA or PKC increases DNA synthesis. TGF beta inhibited PKC-mediated, but not PKA-mediated, DNA synthesis in these cells. The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis. These findings suggest that TGF beta is a strong inhibitor of the proliferation and function of thyroid cells. JF - Endocrinology AU - Pang, X P AU - Park, M AU - Hershman, J M AD - Endocrine Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 45 EP - 50 VL - 131 IS - 1 SN - 0013-7227, 0013-7227 KW - Endothelial Growth Factors KW - 0 KW - Iodides KW - Transforming Growth Factor beta KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Protein Kinases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Endothelial Growth Factors -- pharmacology KW - Animals KW - Thyrotropin -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Fibroblast Growth Factors -- pharmacology KW - Insulin-Like Growth Factor I -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Cell Line KW - Protein Kinase C -- metabolism KW - Transforming Growth Factor beta -- pharmacology KW - Protein Kinases -- metabolism KW - Iodides -- metabolism KW - Thyroid Gland -- drug effects KW - DNA -- biosynthesis KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73014096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Transforming+growth+factor-beta+blocks+protein+kinase-A-mediated+iodide+transport+and+protein+kinase-C-mediated+DNA+synthesis+in+FRTL-5+rat+thyroid+cells.&rft.au=Pang%2C+X+P%3BPark%2C+M%3BHershman%2C+J+M&rft.aulast=Pang&rft.aufirst=X&rft.date=1992-07-01&rft.volume=131&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-27 N1 - Date created - 1992-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat. AN - 73013684; 1351857 AB - Expression of the proliferating cell nuclear antigen (PCNA) was examined in normal rat intestinal tissues and in carcinogen-treated nonneoplastic and neoplastic colonic mucosa. In the normal intestine, PCNA expression was confined to the expected region of the proliferative compartment. A strong correlation was observed between PCNA labeling index and both [3H]thymidine labeling index (R = 0.993, P = 0.007) and percent of cells in S phase as determined by flow cytometry (R = 0.982, P = 0.018) and between the location of the maximal staining for PCNA and [3H]thymidine (R = 0.997, P less than 0.05). In animals treated with dimethylhydrazine (DMH), crypt hyperplasia, an increased PCNA labeling index, and shifts in both the region of maximal and the upper extent of PCNA expression were observed during DMH exposure; significant crypt hyperplasia and expansion of the PCNA-positive compartment persisted after completion of DMH injections. The patterns of PCNA expression and bromodeoxyuridine incorporation were similar in DMH-induced tumors. It is concluded that PCNA immunohistochemistry can be used as a reliable marker of the proliferative compartment in both normal and neoplastic colonic mucosa. JF - Gastroenterology AU - Yamada, K AU - Yoshitake, K AU - Sato, M AU - Ahnen, D J AD - Department of Medicine, Denver Veterans Administration Medical Center, Colorado. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 160 EP - 167 VL - 103 IS - 1 SN - 0016-5085, 0016-5085 KW - Antigens, Neoplasm KW - 0 KW - Carcinogens KW - Dimethylhydrazines KW - Nuclear Proteins KW - Proliferating Cell Nuclear Antigen KW - 1,2-Dimethylhydrazine KW - IX068S9745 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Dimethylhydrazines -- pharmacology KW - Carcinogens -- pharmacology KW - Animals KW - Reference Values KW - Rats, Inbred F344 KW - Antigens, Neoplasm -- analysis KW - Tissue Distribution KW - Male KW - Nuclear Proteins -- analysis KW - Intestinal Mucosa -- immunology KW - Precancerous Conditions -- immunology KW - Colonic Neoplasms -- immunology KW - Colonic Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73013684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Proliferating+cell+nuclear+antigen+expression+in+normal%2C+preneoplastic%2C+and+neoplastic+colonic+epithelium+of+the+rat.&rft.au=Yamada%2C+K%3BYoshitake%2C+K%3BSato%2C+M%3BAhnen%2C+D+J&rft.aulast=Yamada&rft.aufirst=K&rft.date=1992-07-01&rft.volume=103&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-24 N1 - Date created - 1992-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sarcomas of the head and neck. Prognostic factors and treatment strategies. AN - 73009353; 1606539 AB - The authors reviewed 164 cases of head and neck sarcoma from adult patients seen at the University of California, Los Angeles (UCLA), between 1955 and 1988. The median follow-up was 70 months. Multivariate analysis demonstrated that tumor grade, size, and surgical margin status were the most important independent prognostic factors. Thirty-one percent (27 of 85) of patients with high-grade lesions were free of disease versus 81% (44 of 55) with low-grade lesions at last follow-up. Sixty-seven percent (50 of 76) of patients with lesions smaller than 5 cm were free of disease versus 38% (33 of 88) with lesions larger than 5 cm. In 16 patients, low-grade lesions, measuring less than 5 cm and with negative margins histologically, were controlled with surgery alone. For the 94 patients whose primary tumors were treated at UCLA, local control was achieved in 52% (26 of 50) of patients treated with surgery alone and 90% (20 of 22) with combined therapy (surgery and radiation therapy [RT] with or without chemotherapy). Seventy-five percent (6 of 8) of patients with positive surgical margins treated with postoperative RT achieved local control versus 26% (5 of 19) of patients receiving no additional treatment. In conclusion, surgery alone appears to be adequate treatment for small, low-grade tumors and negative surgical margins. Patients with incomplete resection or high-grade tumors should receive aggressive treatment--surgery and RT. JF - Cancer AU - Tran, L M AU - Mark, R AU - Meier, R AU - Calcaterra, T C AU - Parker, R G AD - Department of Radiation Therapy, Veterans Administration Wadsworth Medical Center, Los Angeles, CA 90073. Y1 - 1992/07/01/ PY - 1992 DA - 1992 Jul 01 SP - 169 EP - 177 VL - 70 IS - 1 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphatic Metastasis KW - Humans KW - Osteosarcoma -- pathology KW - Retrospective Studies KW - Hemangiopericytoma -- therapy KW - Hemangiopericytoma -- pathology KW - Fibrosarcoma -- mortality KW - Osteosarcoma -- mortality KW - Adult KW - Hemangiosarcoma -- pathology KW - Neoplasm Metastasis KW - Osteosarcoma -- therapy KW - Male KW - Combined Modality Therapy KW - Hemangiopericytoma -- mortality KW - Prognosis KW - Neurilemmoma -- pathology KW - Neurofibroma -- mortality KW - Fibrosarcoma -- pathology KW - Dose-Response Relationship, Radiation KW - Hemangiosarcoma -- therapy KW - Neurilemmoma -- mortality KW - Neurofibroma -- pathology KW - Neurilemmoma -- therapy KW - Fibrosarcoma -- therapy KW - Hemangiosarcoma -- mortality KW - Antineoplastic Agents -- therapeutic use KW - Neurofibroma -- therapy KW - Female KW - Head and Neck Neoplasms -- therapy KW - Sarcoma -- mortality KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Sarcoma -- therapy KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73009353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Sarcomas+of+the+head+and+neck.+Prognostic+factors+and+treatment+strategies.&rft.au=Tran%2C+L+M%3BMark%2C+R%3BMeier%2C+R%3BCalcaterra%2C+T+C%3BParker%2C+R+G&rft.aulast=Tran&rft.aufirst=L&rft.date=1992-07-01&rft.volume=70&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-21 N1 - Date created - 1992-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combat-Related Posttraumatic Stress Disorder and Severity of Substance Abuse in Vietnam Veterans AN - 61309358; 93Z8860 AB - Combat-exposed Vietnam-theater veterans (V-tVs) & Vietnam-era veterans (V-eVs) without war zone duty (N = 108 & 151, respectively) seeking treatment for substance abuse disorders in Seattle, Wash, were administered a battery of psychometric assessment measures, including one for posttraumatic stress disorder (PTSD). Analysis yielded no significant differences between V-tVs & V-eVs on alcoholism & drug abuse problems, but V-tVs suffering from PTSD scored significantly higher than non-PTSD V-tVs on several scales, & were at greater risk for concurrent alcohol & drug abuse disorders. The overall severity & ideational reexperiencing symptoms of PTSD were more strongly associated with drug than alcohol abuse, while the reverse was true for physiological arousal symptoms. These results confirm the hypothesis that substance abuse severity is associated more specifically with PTSD than with combat duty per se. Substance abuse becomes a maladaptive means of dealing with the cognitive & physiological symptoms of PTSD. 2 Tables, 30 References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - McFall, Miles E AU - Mackay, Priscilla W AU - Donovan, Dennis M AD - Veterans Administration Medical Center Psychology Service, 1660 South Columbian Way Seattle WA 98108 Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 357 EP - 363 VL - 53 IS - 4 SN - 0096-882X, 0096-882X KW - posttraumatic stress disorder/substance abuse, Vietnam-theater veterans KW - psychometric tests KW - substance abuse treatment clients, Seattle, Washington KW - Veterans KW - Substance Abuse KW - Treatment Programs KW - Vietnam War KW - Seattle, Washington KW - Posttraumatic Stress Disorder KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61309358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Combat-Related+Posttraumatic+Stress+Disorder+and+Severity+of+Substance+Abuse+in+Vietnam+Veterans&rft.au=McFall%2C+Miles+E%3BMackay%2C+Priscilla+W%3BDonovan%2C+Dennis+M&rft.aulast=McFall&rft.aufirst=Miles&rft.date=1992-07-01&rft.volume=53&rft.issue=4&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Vietnam War; Veterans; Substance Abuse; Seattle, Washington; Treatment Programs ER - TY - JOUR T1 - Possible substrates of ethanol reinforcement: GABA and dopamine. AN - 73057022; 1321582 JF - Annals of the New York Academy of Sciences AU - Harris, R A AU - Brodie, M S AU - Dunwiddie, T V AD - Denver Veterans Administration Medical Center, Colorado. Y1 - 1992/06/28/ PY - 1992 DA - 1992 Jun 28 SP - 61 EP - 69 VL - 654 SN - 0077-8923, 0077-8923 KW - Receptors, GABA-A KW - 0 KW - Ethanol KW - 3K9958V90M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Reward KW - Humans KW - Receptors, GABA-A -- physiology KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Reinforcement (Psychology) KW - Dopamine -- metabolism KW - gamma-Aminobutyric Acid -- metabolism KW - Alcoholism -- physiopathology KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73057022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Possible+substrates+of+ethanol+reinforcement%3A+GABA+and+dopamine.&rft.au=Harris%2C+R+A%3BBrodie%2C+M+S%3BDunwiddie%2C+T+V&rft.aulast=Harris&rft.aufirst=R&rft.date=1992-06-28&rft.volume=654&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-17 N1 - Date created - 1992-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of interleukin 2 production but not methionine adenosyltransferase activity or S-adenosylmethionine turnover in Jurkat T-cells. AN - 72985567; 1596894 AB - We have recently reported that methionine adenosyltransferase (MAT) in resting human peripheral blood T-cells is primarily present in the form of a precursor which we named lambda. This protein decreases upon cell stimulation, as both MAT activity and the amount of the catalytic alpha/alpha' subunits of the enzyme increase. When resting cells are activated by phytohemagglutinin, the decrease in lambda and increase in alpha/alpha' occurs after interleukin 2 (IL-2) production and before DNA synthesis. The human T-leukemia cell line, Jurkat, is unique in its ability to produce IL-2 in response to exogenous stimuli such as T-cell mitogens and therefore provides a convenient model for studying biochemical reactions involved in T-cell activation. In this study the regulation of MAT activity and S-adenosylmethionine (AdoMet) in resting and activated Jurkat cells was investigated. Here we report that MAT activity in unstimulated Jurkat cells is about 10- and 3-fold higher than the activity in resting and activated peripheral blood mononuclear cells, respectively. Activation of Jurkat cells with phytohemagglutinin resulted in increased IL-2-production, but not an increase in MAT activity. Identical results were obtained using freshly isolated cells from acute lymphoblastic leukemia patients. AdoMet utilization and pool size were approximately 3- and 10-fold higher, respectively, in Jurkat cells compared to peripheral blood mononuclear cells, and both parameters were unaffected by phytohemagglutinin stimulation. Jurkat MAT was determined to be structurally indistinguishable from enzyme from T- or B-leukemia cells but was different from resting, normal T-cells in that it lacked the lambda form. Furthermore, unlike MAT in resting T-cells, the relative amounts of the alpha, alpha', and beta subunits of the enzyme did not change throughout the course of IL-2 induction. We conclude that AdoMet metabolism and MAT activity in Jurkat cells are constitutively high and that induction of IL-2 synthesis in these cells is independent of changes in AdoMet synthesis or turnover. The lack of the lambda form and the difference in MAT regulation between leukemic T-cells and peripheral blood mononuclear cells may be exploited in the design of specific chemotherapeutic agents. JF - Cancer research AU - De La Rosa, J AU - Geller, A M AU - LeGros, H L AU - Kotb, M AD - Veterans Administration Medical Center, Research Service, Memphis, Tennessee 38104. Y1 - 1992/06/15/ PY - 1992 DA - 1992 Jun 15 SP - 3361 EP - 3366 VL - 52 IS - 12 SN - 0008-5472, 0008-5472 KW - Enzyme Precursors KW - 0 KW - Interleukin-2 KW - Phytohemagglutinins KW - Ionomycin KW - 56092-81-0 KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - Methionine Adenosyltransferase KW - EC 2.5.1.6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Lymphocyte Activation KW - Tumor Cells, Cultured KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Ionomycin -- pharmacology KW - Enzyme Precursors -- biosynthesis KW - Leukemia, T-Cell -- metabolism KW - S-Adenosylmethionine -- metabolism KW - Interleukin-2 -- biosynthesis KW - Methionine Adenosyltransferase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72985567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Induction+of+interleukin+2+production+but+not+methionine+adenosyltransferase+activity+or+S-adenosylmethionine+turnover+in+Jurkat+T-cells.&rft.au=De+La+Rosa%2C+J%3BGeller%2C+A+M%3BLeGros%2C+H+L%3BKotb%2C+M&rft.aulast=De+La+Rosa&rft.aufirst=J&rft.date=1992-06-15&rft.volume=52&rft.issue=12&rft.spage=3361&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-06 N1 - Date created - 1992-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Predictive value of objective esophageal insufflation testing for acquisition of tracheoesophageal speech. AN - 85194859; pmid-1602920 AB - This prospective study was undertaken to assess the predictive value of esophageal insufflation on the acquisition of tracheoesophageal (TE) speech. Fourteen total laryngectomy patients were evaluated prior to tracheoesophageal puncture (TEP) using objective esophageal pressure measurements. These patients then were followed prospectively for 6 to 13 months. Speech was assessed at the time of prosthesis fitting, at 1 month, at less than 6 months, and at greater than 6 months post-TEP. No patient underwent pharyngeal myotomy. Pre-TEP esophageal insufflation pressure was associated (P = .065) with successful TE speech at the time of prosthesis fitting, but was not associated with successful TE speech acquisition after 6 months. This study's results suggest that patients with poor pre-TEP esophageal insufflation test results will usually obtain successful TE speech given adequate time and training, even without pharyngeal myotomy. JF - The Laryngoscope AU - Callaway, E AU - Truelson, J M AU - Wolf, G T AU - Thomas-Kincaid, L AU - Cannon, S AD - Department of Speech Pathology, Veterans Administration Hospital, Ann Arbor, Mich. PY - 1992 SP - 704 EP - 708 VL - 102 IS - 6 SN - 0023-852X, 0023-852X KW - Esophagus KW - Probability KW - Voice Quality KW - Speech Intelligibility KW - Human KW - Aged KW - Rheology KW - Prospective Studies KW - Laryngectomy KW - Middle Age KW - Larynx, Artificial KW - Pressure KW - Speech KW - Time Factors KW - Phonation KW - Male KW - Female KW - Speech, Esophageal KW - Insufflation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85194859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Predictive+value+of+objective+esophageal+insufflation+testing+for+acquisition+of+tracheoesophageal+speech.&rft.au=Callaway%2C+E%3BTruelson%2C+J+M%3BWolf%2C+G+T%3BThomas-Kincaid%2C+L%3BCannon%2C+S&rft.aulast=Callaway&rft.aufirst=E&rft.date=1992-06-01&rft.volume=102&rft.issue=6&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Review of the experience with cefprozil for the treatment of lower respiratory tract infections. AN - 73039560; 1617044 AB - A regimen of cefprozil (500 mg twice daily), a new oral cephalosporin with a broad in vitro spectrum of antimicrobial activity, was compared to standard regimens of cefaclor (500 mg three times daily), cefuroxime axetil (500 mg twice daily), or amoxicillin/clavulanate (500 mg/125 mg three times daily) for the treatment of lower respiratory tract infections (mainly bronchitis and acute exacerbations of chronic bronchitis) in adults in three open-label, randomized trials. In the first trial, in which bacterial pathogens were isolated in initial cultures for only one-third of the patients, 90% of the pathogens were susceptible to cefprozil. A satisfactory clinical response was noted for 84% of the evaluable patients who received cefprozil versus 79% of those who received cefaclor for treatment of lower respiratory tract infections; rates of bacteriologic efficacy were 82% and 78%, respectively. In the second study rates of satisfactory clinical response were 96% with cefprozil and 83% with cefuroxime axetil (P less than .03) for treatment of bronchitis; the respective bacteriologic response rates were 100% and 92%. In the third trial, clinical efficacy was 91% for cefprozil and 87% for amoxicillin/clavulanate for treatment of bronchitis; bacteriologic efficacy was 95% and 96%, respectively. Tolerability and safety profiles were comparable, except that there was a higher rate of diarrhea among patients who received amoxicillin/clavulanate (P = .03). JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Pelletier, L L AD - Medical Service, Wichita Veterans Administration Medical Center, Kansas 67218. Y1 - 1992/06// PY - 1992 DA - June 1992 SP - S238 EP - 43; discussion S244-5 VL - 14 Suppl 2 SN - 1058-4838, 1058-4838 KW - Cephalosporins KW - 0 KW - Clavulanic Acids KW - cefprozil KW - 4W0459ZA4V KW - Cefaclor KW - 69K7K19H4L KW - Amoxicillin-Potassium Clavulanate Combination KW - 74469-00-4 KW - Amoxicillin KW - 804826J2HU KW - Cefuroxime KW - O1R9FJ93ED KW - Index Medicus KW - Acute Disease KW - Drug Therapy, Combination -- adverse effects KW - Cefaclor -- therapeutic use KW - Humans KW - Clavulanic Acids -- therapeutic use KW - Amoxicillin -- adverse effects KW - Amoxicillin -- therapeutic use KW - Cefuroxime -- adverse effects KW - Clavulanic Acids -- adverse effects KW - Cefuroxime -- therapeutic use KW - Drug Therapy, Combination -- therapeutic use KW - Cefaclor -- adverse effects KW - Cephalosporins -- adverse effects KW - Bronchitis -- drug therapy KW - Pneumonia, Pneumococcal -- drug therapy KW - Cephalosporins -- therapeutic use KW - Bronchopneumonia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73039560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Review+of+the+experience+with+cefprozil+for+the+treatment+of+lower+respiratory+tract+infections.&rft.au=Pelletier%2C+L+L&rft.aulast=Pelletier&rft.aufirst=L&rft.date=1992-06-01&rft.volume=14+Suppl+2&rft.issue=&rft.spage=S238&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-05 N1 - Date created - 1992-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Management and epidemiologic analyses of an outbreak due to methicillin-resistant Staphylococcus aureus. AN - 73021373; 1605142 AB - Following implementation of special measures to control a nosocomial outbreak of methicillin-resistant Staphylococcus aureus (MRSA), we used immunoblot typing in conjunction with antimicrobial susceptibility testing to investigate the epidemiology of this event and to determine whether this outbreak represented the failure of infection control measures to limit the spread of previously endemic MRSA strains or the introduction of a new strain of MRSA. Isolates of MRSA recovered from hospitalized patients were initially categorized on the basis of antimicrobial susceptibility results. Organisms susceptible to ciprofloxacin and/or trimethoprim/sulfamethoxazole were recovered from patients at a relatively constant rate prior to December 1988 and were categorized as endemic isolates. Subsequently, there was an outbreak due to organisms resistant to both of these antibiotics; these were therefore categorized as outbreak isolates. Isolates were later characterized by immunoblot typing. Prior to this analysis, isolates were given code numbers so that clinical and epidemiologic data as well as resistance patterns were not known until this testing was complete. Between January 1986 and November 1988, an average of 3.9 patients per month acquired nosocomial MRSA in the Sepulveda Veterans Administration Medical Center. In contrast, from December 1988 to October 1989, 369 MRSA isolates were collected from 125 patients (an average of 11.4 patients per month). Prior to December 1988, all tested nosocomial isolates of MRSA were susceptible to ciprofloxacin and/or to trimethoprim/sulfamethoxazole. In contrast, the outbreak was due to spread of MRSA isolates resistant to these antibiotics. Immunoblot typing of 204 isolates from 98 individuals identified five distinct immunoblot types of which types B and C were by far the most common. Type B was highly associated with outbreak isolates, whereas type C was associated with endemic isolates (p less than 0.001). All sequential isolates from single patients that belonged to different susceptibility categories demonstrated discordant immunoblot types. In contrast, concordant immunoblot types were observed for 25 of 27 sequential isolates that displayed minor variations in antimicrobial resistance. The institution of more stringent infection control measures was followed by the return of nosocomial MRSA acquisition rates to pre-outbreak levels. Although novobiocin and trimethoprim/sulfamethoxazole were extensively used to treat patients harboring outbreak and endemic isolates, respectively, in no instance was the initial MRSA isolate from any patient resistant to novobiocin and only 6% of initial endemic isolates displayed trimethoprim/sulfamethoxazole resistance. A modest, significant increase in the resistance of endemic isolates to various other antimicrobial agents was noted however. Immunoblot analyses provided strong, corroborative evidence that at least two separate strains of MRSA were present during the outbreak and that a newly introduced strain with a distinctive antimicrobial resistance pattern was primarily responsible for the rapid spread of MRSA during the outbreak. The observation that previously effective infection control measures failed to prevent the nosocomial spread of a newly introduced community-acquired MRSA strain suggests that a single set of control measures may not be equally efficacious against all strains of MRSA. In this regard, previously reported variations in resistance to topical antimicrobials and/or antiseptics, and differences in virulence factors such as colonization potential, invasiveness, and survival on fomites, may warrant further study. Control of the outbreak strain of MRSA in our institution did occur after the implementation of more strenuous isolation procedures.(ABSTRACT TRUNCATED) JF - The American journal of medicine AU - Goetz, M B AU - Mulligan, M E AU - Kwok, R AU - O'Brien, H AU - Caballes, C AU - Garcia, J P AD - Department of Medicine, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1992/06// PY - 1992 DA - June 1992 SP - 607 EP - 614 VL - 92 IS - 6 SN - 0002-9343, 0002-9343 KW - Novobiocin KW - 17EC19951N KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Organizational Policy KW - Humans KW - Trimethoprim, Sulfamethoxazole Drug Combination -- therapeutic use KW - Occupational Diseases -- prevention & control KW - Serotyping KW - Infection Control -- organization & administration KW - Evaluation Studies as Topic KW - Personnel, Hospital KW - Infection Control -- methods KW - Seasons KW - Trimethoprim Resistance KW - Incidence KW - Novobiocin -- therapeutic use KW - Occupational Diseases -- epidemiology KW - California -- epidemiology KW - Microbial Sensitivity Tests KW - Occupational Diseases -- microbiology KW - Prevalence KW - Hospitals, Veterans KW - Staphylococcal Infections -- epidemiology KW - Staphylococcal Infections -- prevention & control KW - Disease Outbreaks -- prevention & control KW - Carrier State -- prevention & control KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Methicillin Resistance KW - Disease Outbreaks -- statistics & numerical data KW - Staphylococcal Infections -- microbiology KW - Staphylococcus aureus KW - Carrier State -- epidemiology KW - Carrier State -- microbiology KW - Cross Infection -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73021373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Management+and+epidemiologic+analyses+of+an+outbreak+due+to+methicillin-resistant+Staphylococcus+aureus.&rft.au=Goetz%2C+M+B%3BMulligan%2C+M+E%3BKwok%2C+R%3BO%27Brien%2C+H%3BCaballes%2C+C%3BGarcia%2C+J+P&rft.aulast=Goetz&rft.aufirst=M&rft.date=1992-06-01&rft.volume=92&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-10 N1 - Date created - 1992-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preoperative combined chemotherapy and radiation therapy plus radical surgery in advanced head and neck cancer. Five-year results with impressive complete response rates and high survival. AN - 72913647; 1571903 AB - Radiation therapy combined with cisplatin as a chemoradiation sensitizer (CT/RT) has been reported to enhance tumor response in squamous cell carcinoma of the head and neck. In the present study, CT/RT was used preoperatively in advanced Stage III and IV head and neck cancer. Fifty-three patients were entered prospectively into a Phase II study. Treatment consisted of 4500 cGy of radiation therapy in 5 weeks combined with cisplatin 20 mg/m2 for 4 days during weeks 1 and 4 of radiation therapy. This was followed 4 to 8 weeks later by curative surgery. Pretherapy dental care; long-term nutritional support; individualized skin, mouth, and wound care; and continuous interdisciplinary communication were integral parts of this regimen. In four patients, CT/RT toxicity was seen (8%); three episodes of skin reaction or stomatitis and three episodes of leukopenia (less than 2500/microliters), causing a delay in CT/RT treatment in one patient. Three patients died of other causes during the preoperative interval, without clinical evidence of toxicity. Fifty patients (94%) had a complete (CR) or partial response (PR) to CT/RT. Clinical CR was seen in 38 of 51 (75%) primary tumors and 21 of 27 (78%) cervical nodes. Forty-one patients (77%) underwent curative surgery. In 27 of 32 (84%) resected CR primary tumors and 16 of 18 (89%) CR metastatic nodes, the surgical specimen was microscopically free of tumor. Postoperative morbidity was 32%. Five patients (12%) required additional surgery for their complications. Perioperative mortality was 5%. Five patients had tumor recurrence: three postoperatively after clinical PR to CT/RT and two in clinical CR patients who refused further treatment after CT/RT, then had a recurrence and were salvaged surgically. No patient with a CR in both the tumor and nodes who underwent surgery had a tumor recurrence. With a follow-up of 8 years (median, 40 months), the median survival for all patients was 45 months. The 5-year actuarial survival rate was 43% for all patients and 55% for patients who had CT/RT and surgery. This multimodality treatment of advanced head and neck cancer has low toxicity and impressive survival. It renders a significant number of patients tumor-free before surgery. These patients may be candidates for additional study triaging additional CT/RT for complete CR only and surgery for PR and biopsy-proved residual disease. JF - Cancer AU - Slotman, G J AU - Doolittle, C H AU - Glicksman, A S AD - Surgical Service, Providence Veterans Administration Medical Center, Rhode Island. Y1 - 1992/06/01/ PY - 1992 DA - 1992 Jun 01 SP - 2736 EP - 2743 VL - 69 IS - 11 SN - 0008-543X, 0008-543X KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Neoplasm Staging KW - Humans KW - Aged KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Survival Analysis KW - Cisplatin -- therapeutic use KW - Preoperative Care -- methods KW - Head and Neck Neoplasms -- therapy KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72913647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Preoperative+combined+chemotherapy+and+radiation+therapy+plus+radical+surgery+in+advanced+head+and+neck+cancer.+Five-year+results+with+impressive+complete+response+rates+and+high+survival.&rft.au=Slotman%2C+G+J%3BDoolittle%2C+C+H%3BGlicksman%2C+A+S&rft.aulast=Slotman&rft.aufirst=G&rft.date=1992-06-01&rft.volume=69&rft.issue=11&rft.spage=2736&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-04 N1 - Date created - 1992-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pantomime, Praxis, and Aphasia AN - 85551330; 9210157 AB - Pantomime productions of aphasic Ss (N = 30, mean age 61.1) with parietal & anterior left cerebral lesions were compared based on the site of lesion: frontal, temporoparietal, parietal, & frontotemporoparietal. All patients were administered the following batteries in this order: Pantomime Recognition Test (PRT), Transitive Pantomime Expression Test (TPET), Intransitive Pantomime Expression Test (IPET), Meaningful Movement Imitation Test (MMIT), & Nonmeaningful Movement Imitation Test (NMIT). All but the PRT were videotaped & scored. Ss were also assessed for general intellectual ability, language impairment, & reading comprehension. No significant differences were found between the four lesion groups, but a trend for best performance among the frontal group & worst performance among the parietal group was noted. Analysis indicates a strong correlation between all measures of pantomime production, recognition, & movement imitation; performance on both the TPET & IPET is correlated with the ability to imitate meaningless gestures; auditory comprehension is correlated with all measures of pantomime production & comprehension; & nonmeaningful imitation is not correlated to the language measures. Factor analysis shows that there is a strong common factor linking pantomiming, comprehension of pantomime movement, & imitation of meaningful & nonmeaningful movements. It is suggested that impaired use of pantomime among aphasic patients is due in part to both reduced symbolic capacity & apraxia. 5 Tables, 25 References. M. Lemons JF - Brain and Language AU - Wang, Lizhao AU - Goodglass, Harold AD - c/o Goodglass-Boston Veterans Administration Medical Center, 150 South Huntington Ave MA 02130 Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 402 EP - 418 VL - 42 IS - 4 SN - 0093-934X, 0093-934X KW - pantomime production ability comparison KW - pantomime tests KW - aphasics with parietal/anterior left cerebral lesions, mean age 61.1 KW - Imitation (34600) KW - Nonverbal Communication (58500) KW - Brain Damage (09400) KW - Aphasia (03400) KW - Comprehension (13950) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85551330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Pantomime%2C+Praxis%2C+and+Aphasia&rft.au=Wang%2C+Lizhao%3BGoodglass%2C+Harold&rft.aulast=Wang&rft.aufirst=Lizhao&rft.date=1992-05-01&rft.volume=42&rft.issue=4&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Brain Damage (09400); Nonverbal Communication (58500); Comprehension (13950); Imitation (34600) ER - TY - JOUR T1 - Gastroenterology today and tomorrow. AN - 85224617; pmid-1595640 JF - The American Journal of Gastroenterology AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. PY - 1992 SP - 559 EP - 561 VL - 87 IS - 5 SN - 0002-9270, 0002-9270 KW - United States KW - Reimbursement Mechanisms KW - Forecasting KW - Societies, Medical KW - Gastroenterology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Gastroenterology+today+and+tomorrow.&rft.au=Graham%2C+D+Y&rft.aulast=Graham&rft.aufirst=D&rft.date=1992-05-01&rft.volume=87&rft.issue=5&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A simplified method for the preparation of tetanus toxin binding fragment for neurobiology. AN - 73120465; 1380109 AB - The non-toxic binding fragment of tetanus toxin (fragment C) binds avidly to neural tissue and has a growing number of neurobiological uses. Its current utility is limited by both its high commercial cost and the complex procedure for its preparation requiring highly purified tetanus toxin. We have developed a short procedure which prepares fragments of tetanus toxin from crude C. tetani extracts. The resultant proteins are atoxic with molecular sizes and immunological properties closely resembling fragment C. These proteins undergo retrograde axonal and apparent transneuronal transport in a fashion similar to fragment C. JF - Journal of neuroscience methods AU - Fishman, P S AU - Farrand, D A AU - Halpern, J L AU - Latham, W C AD - Baltimore Veterans Administration Medical Center, MD. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 229 EP - 236 VL - 42 IS - 3 SN - 0165-0270, 0165-0270 KW - Antibodies, Monoclonal KW - 0 KW - Antigens KW - Neuromuscular Blocking Agents KW - Peptide Fragments KW - Tetanus Toxin KW - tetanus toxin fragment C KW - Index Medicus KW - Immunoblotting KW - Animals KW - Neurons -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - In Vitro Techniques KW - Hypoglossal Nerve -- anatomy & histology KW - Mice KW - Immunohistochemistry KW - Clostridium tetani KW - Antigens -- immunology KW - Molecular Weight KW - Axonal Transport KW - Antibodies, Monoclonal -- immunology KW - Tetanus Toxin -- immunology KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Tetanus Toxin -- metabolism KW - Tetanus Toxin -- chemistry KW - Peptide Fragments -- immunology KW - Neuromuscular Blocking Agents -- metabolism KW - Neuromuscular Blocking Agents -- immunology KW - Neuromuscular Blocking Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73120465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+methods&rft.atitle=A+simplified+method+for+the+preparation+of+tetanus+toxin+binding+fragment+for+neurobiology.&rft.au=Fishman%2C+P+S%3BFarrand%2C+D+A%3BHalpern%2C+J+L%3BLatham%2C+W+C&rft.aulast=Fishman&rft.aufirst=P&rft.date=1992-05-01&rft.volume=42&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+methods&rft.issn=01650270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-15 N1 - Date created - 1992-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of five preparations of synthetic monosodium urate monohydrate crystals. AN - 73025695; 1613710 AB - We conducted preliminary crystallographic investigations and biologic studies on 5 synthetically grown preparations of monosodium urate monohydrate (MSUM) crystals including one preparation of urate spherulites. The 5 crystal preparations exhibited wide variations in morphology, size, surface area, and ultrastructure, but only a few changes in their biologic effects. When injected intraarticularly, urate spherulites were less phlogistic than most acicular forms. Since crystal-cell interactions and inflammatory responses are influenced by crystal size, morphology, and surface characteristics, standardization of methods of preparing MSUM crystals is, therefore, important, particularly when analyzing and comparing results from different research laboratories. JF - The Journal of rheumatology AU - Fam, A G AU - Schumacher, H R AU - Clayburne, G AU - Sieck, M AU - Mandel, N S AU - Cheng, P T AU - Pritzker, K P AD - Veterans Administration Medical Center, Philadelphia, PA. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 780 EP - 787 VL - 19 IS - 5 SN - 0315-162X, 0315-162X KW - Uric Acid KW - 268B43MJ25 KW - Index Medicus KW - Crystallization KW - Phagocytosis -- physiology KW - X-Ray Diffraction KW - Leukocytes -- physiology KW - Inflammation -- chemically induced KW - Microscopy, Electron KW - Microscopy, Electron, Scanning KW - Uric Acid -- metabolism KW - Uric Acid -- adverse effects KW - Uric Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73025695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=A+comparison+of+five+preparations+of+synthetic+monosodium+urate+monohydrate+crystals.&rft.au=Fam%2C+A+G%3BSchumacher%2C+H+R%3BClayburne%2C+G%3BSieck%2C+M%3BMandel%2C+N+S%3BCheng%2C+P+T%3BPritzker%2C+K+P&rft.aulast=Fam&rft.aufirst=A&rft.date=1992-05-01&rft.volume=19&rft.issue=5&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-24 N1 - Date created - 1992-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitative and analytical studies in the diagnosis of mesothelioma. AN - 73019595; 1609158 AB - The vast majority of patients with malignant mesothelioma of the pleura or peritoneum have an abnormal tissue asbestos content as assessed by digestion techniques. These procedures allow for the quantification of asbestos bodies, as well as numbers and types of mineral fibers. In general, analyses of mineral fiber content correlate well with occupational exposure history. Such analyses are useful for the identification of asbestos-related mesotheliomas and separation from those due to other causes. JF - Seminars in diagnostic pathology AU - Roggli, V L AD - Department of Pathology, Durham Veterans Administration, NC. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 162 EP - 168 VL - 9 IS - 2 SN - 0740-2570, 0740-2570 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Occupational Exposure -- adverse effects KW - Microscopy, Electron KW - Environmental Exposure -- adverse effects KW - Asbestos -- analysis KW - Mesothelioma -- diagnosis KW - Mesothelioma -- etiology KW - Asbestos -- adverse effects KW - Pleural Neoplasms -- etiology KW - Pleural Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73019595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+diagnostic+pathology&rft.atitle=Quantitative+and+analytical+studies+in+the+diagnosis+of+mesothelioma.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1992-05-01&rft.volume=9&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Seminars+in+diagnostic+pathology&rft.issn=07402570&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-23 N1 - Date created - 1992-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels. AN - 72988830; 1603084 AB - Fibroblasts represent one of the in vivo sites of insulin-like growth factor-I (IGF-I) production. In this study rat dermal fibroblasts in culture were used as a model system to assess the effect of activation of protein kinase-C on the levels of the mRNAs encoding IGF-I and another growth factor, basic fibroblast growth factor (bFGF). IGF-I and bFGF mRNA levels were determined using a solution hybridization/RNase protection assay. Treatment of cells in serum-free medium containing 0.25% BSA (MEM + BSA) with the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) decreased IGF-I and increased bFGF mRNA levels in a time- and dose-dependent fashion. The peak effect of 100 nM PMA on IGF-I mRNA levels occurred at 9 h, whereas the peak effect on bFGF mRNA levels occurred after 3 h of incubation. In dose-response studies, half-maximal inhibition of IGF-I mRNA levels was achieved with approximately 0.08 nM PMA, while half-maximal stimulation of bFGF mRNA levels was achieved with approximately 3 nM PMA. Inhibition of protein synthesis with cycloheximide abrogated the effect of PMA on bFGF mRNA levels, but only partially inhibited the effect of PMA on IGF-I mRNA levels. Studies employing sphingosine or staurosporine to inhibit protein kinase-C or preincubation in high doses of PMA to down-regulate protein kinase-C suggested that the effect of PMA on IGF-I and bFGF mRNA levels was mediated by activation of protein kinase-C, although both staurosporine and sphingosine had independent effects on the levels of these mRNAs and down-regulation of protein kinase-C had a sustained effect on IGF-I mRNA levels. Ligands known to activate protein kinase-C were then tested. Treatment of cells with 100 micrograms/ml of the synthetic diacylglycerol 1-oleoyl-2-acetyl-sn-glycerol decreased IGF-I mRNA levels to 25% and increased bFGF mRNA levels to 520% of the level present in cells maintained in MEM + BSA. Treatment of cells with thrombin or bradykinin also decreased IGF-I mRNA levels and increased bFGF mRNA levels, but whereas the effect of thrombin on IGF-I mRNA levels was marked, the effect of bradykinin was minimal, and whereas the effect of thrombin on bFGF mRNA levels was sustained, the effect of bradykinin was transient.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Molecular endocrinology (Baltimore, Md.) AU - Lowe, W L AU - Yorek, M A AU - Karpen, C W AU - Teasdale, R M AU - Hovis, J G AU - Albrecht, B AU - Prokopiou, C AD - Department of Internal Medicine, University of Iowa College of Medicine, Veterans Administration Medical Center, Iowa City. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 741 EP - 752 VL - 6 IS - 5 SN - 0888-8809, 0888-8809 KW - RNA, Messenger KW - 0 KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Thrombin KW - EC 3.4.21.5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Rats KW - Animals KW - Thrombin -- pharmacology KW - In Vitro Techniques KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation KW - Bradykinin -- pharmacology KW - Fibroblasts -- metabolism KW - RNA, Messenger -- biosynthesis KW - Insulin-Like Growth Factor I -- genetics KW - Fibroblast Growth Factor 2 -- genetics KW - Protein Kinase C -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72988830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Activation+of+protein+kinase-C+differentially+regulates+insulin-like+growth+factor-I+and+basic+fibroblast+growth+factor+messenger+RNA+levels.&rft.au=Lowe%2C+W+L%3BYorek%2C+M+A%3BKarpen%2C+C+W%3BTeasdale%2C+R+M%3BHovis%2C+J+G%3BAlbrecht%2C+B%3BProkopiou%2C+C&rft.aulast=Lowe&rft.aufirst=W&rft.date=1992-05-01&rft.volume=6&rft.issue=5&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-16 N1 - Date created - 1992-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic/semichronic limbic epilepsy produced by microinjection of tetanus toxin in cat hippocampus. AN - 72962199; 1592013 AB - We describe an animal preparation in which a semichronic or chronic limbic epileptiform syndrome can be produced reliably by unilateral microinjection of tetanus toxin in cat ventral hippocampus. Injections were given at 1-week intervals until abnormal EEG activity was observed. After two to five injections, the animals abruptly began to exhibit intermittent spikes and subclinical discharges that soon gave way to spontaneous and recurrent behavioral seizures which gradually increased in frequency, duration, and severity in the next 12-48 h. Anticonvulsant therapy (phenobarbital, PB) was required within the first 3 days of the syndrome, since life-threatening generalized tonic-clonic seizures (GTCS) and status epilepticus would develop if the animal were left untreated. If severe seizures were prevented by antiepileptic drugs (AEDs) there was complete remission of the syndrome and repeat injection was necessary to reinitiate seizures. Animals that experienced severe seizures or that were reinjected after remission developed a chronic seizure syndrome and could be maintained with AEDs for long times (greater than 1 year) without significant debilitation. Although early spikes and subclinical discharges were typically focal to ipsilateral limbic sites, initial seizures appeared explosively in the form of a high-amplitude, high-frequency discharge, which often had an apparently bilateral limbic onset. On the other hand, chronic seizures had much more gradual onset and spread, often consisting of periodic sharp waves or low-amplitude sinusoidal discharge that was more clearly focal to ipsilateral limbic sites. Throughout the syndrome, ictal behavioral manifestations were highly stereotyped and very comparable to those described by other investigators in studies of clinical and experimental limbic epilepsy. All animals exhibited signs of independent contralateral involvement during the syndrome, ranging from independent contralateral spikes to subclinical discharges with a clear contralateral onset. None of the animals exhibited structural lesions on histologic examination at the level of light microscopy. JF - Epilepsia AU - Darcey, T M AU - Williamson, P D AD - Neurology Service, Veterans Administration Medical Center, West Haven, Connecticut. PY - 1992 SP - 402 EP - 419 VL - 33 IS - 3 SN - 0013-9580, 0013-9580 KW - Tetanus Toxin KW - 0 KW - Index Medicus KW - Epilepsy, Temporal Lobe -- physiopathology KW - Animals KW - Amygdala -- physiopathology KW - Electroencephalography KW - Cats KW - Models, Neurological KW - Microinjections KW - Female KW - Stereotaxic Techniques KW - Limbic System -- physiopathology KW - Epilepsies, Partial -- physiopathology KW - Tetanus Toxin -- administration & dosage KW - Epilepsies, Partial -- chemically induced KW - Disease Models, Animal KW - Tetanus Toxin -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72962199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Chronic%2Fsemichronic+limbic+epilepsy+produced+by+microinjection+of+tetanus+toxin+in+cat+hippocampus.&rft.au=Darcey%2C+T+M%3BWilliamson%2C+P+D&rft.aulast=Darcey&rft.aufirst=T&rft.date=1992-05-01&rft.volume=33&rft.issue=3&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-01 N1 - Date created - 1992-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin E in the treatment of chemotherapy-induced mucositis. AN - 72936004; 1580295 AB - To determine the efficacy of vitamin E in the treatment of chemotherapy-induced mucositis in patients with malignancy. A randomized, double-blind, placebo-controlled study was performed to evaluate the efficacy of topical vitamin E in the treatment of oral mucositis in patients receiving chemotherapy for various types of malignancy. A total of 18 patients, 17 of whom had solid tumors and one with acute leukemia, were included in this study. Lesions were observed daily prior to and 5 days after topical application of either vitamin E or placebo oil. Six of nine patients receiving vitamin E had complete resolution of their oral lesions. In eight of nine patients who received placebo, complete resolution of their oral lesions was not observed. This difference is statistically significant (p = 0.025 by Fisher's exact test). No toxicity was observed in this study. These results suggest that vitamin E may be an effective therapy in patients with chemotherapy-induced mucositis. JF - The American journal of medicine AU - Wadleigh, R G AU - Redman, R S AU - Graham, M L AU - Krasnow, S H AU - Anderson, A AU - Cohen, M H AD - Division of Medical Oncology, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 481 EP - 484 VL - 92 IS - 5 SN - 0002-9343, 0002-9343 KW - Antineoplastic Agents KW - 0 KW - Vitamin E KW - 1406-18-4 KW - Abridged Index Medicus KW - Index Medicus KW - Mouth Mucosa KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Administration, Topical KW - Stomatitis -- chemically induced KW - Vitamin E -- therapeutic use KW - Stomatitis -- drug therapy KW - Vitamin E -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72936004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Vitamin+E+in+the+treatment+of+chemotherapy-induced+mucositis.&rft.au=Wadleigh%2C+R+G%3BRedman%2C+R+S%3BGraham%2C+M+L%3BKrasnow%2C+S+H%3BAnderson%2C+A%3BCohen%2C+M+H&rft.aulast=Wadleigh&rft.aufirst=R&rft.date=1992-05-01&rft.volume=92&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-11 N1 - Date created - 1992-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. AN - 72911544; 1567206 AB - Previous work suggested that the oxidation of uroporphyrinogen to uroporphyrin is catalyzed by cytochrome P450IA2. Here we determined whether purified reconstituted mouse P450IA1 and IA2 oxidize uroporphyrinogen. Cytochromes P450IA1 and IA2 were purified from hepatic microsomes from 3-methylcholanthrene (MC)-treated C57BL/6 mice, using a combination of affinity chromatography and high performance liquid chromatography. Reconstituted P450IA1 was more active than P450IA2 in catalyzing ethoxyresorufin-O-deethylase (EROD) activity, whereas P450IA2 was more active than P450IA1 in catalyzing uroporphyrinogen oxidation (UROX). Both reactions required NADPH, NADPH-cytochrome P450 reductase, and either P450IA1 or IA2. Ketoconazole competitively inhibited both EROD and UROX activities, in microsomes from MC-treated mice. Ketoconazole also inhibited UROX catalyzed by reconstituted P450IA2. In contrast, ketoconazole did not inhibit UROX catalyzed by xanthine oxidase in the presence of iron-EDTA. Superoxide dismutase, catalase, and mannitol inhibited UROX catalyzed by xanthine oxidase/iron-EDTA, but did not affect UROX catalyzed by either microsomes or reconstituted P450IA2. These results suggest that UROX catalyzed by P450IA2 in microsomes and reconstituted systems does not involve free reactive oxygen species. Two known substrates of cytochrome P450IA2, 2-amino-3,4-dimethylimidazole[4,5-f]quinoline and phenacetin, were shown to inhibit the microsomal UROX reaction, suggesting that uroporphyrinogen binds to a substrate-binding site on the cytochrome P450. JF - Archives of biochemistry and biophysics AU - Lambrecht, R W AU - Sinclair, P R AU - Gorman, N AU - Sinclair, J F AD - Veterans Administration, White River Junction, Vermont 05009. Y1 - 1992/05/01/ PY - 1992 DA - 1992 May 01 SP - 504 EP - 510 VL - 294 IS - 2 SN - 0003-9861, 0003-9861 KW - Quinolines KW - 0 KW - Uroporphyrinogens KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxidoreductases KW - EC 1.- KW - Cytochrome P-450 CYP1A2 KW - EC 1.14.14.1 KW - Phenacetin KW - ER0CTH01H9 KW - 2-amino-3,4-dimethylimidazo(4,5-f)quinoline KW - G2Q7M1P33X KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Oxidation-Reduction KW - Phenacetin -- pharmacology KW - Animals KW - Quinolines -- pharmacology KW - Methylcholanthrene -- pharmacology KW - Kinetics KW - Mice, Inbred C57BL KW - Mice KW - Ketoconazole -- pharmacology KW - Male KW - Oxidoreductases -- isolation & purification KW - Oxidoreductases -- metabolism KW - Microsomes, Liver -- enzymology KW - Cytochrome P-450 Enzyme System -- isolation & purification KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Uroporphyrinogens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72911544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Uroporphyrinogen+oxidation+catalyzed+by+reconstituted+cytochrome+P450IA2.&rft.au=Lambrecht%2C+R+W%3BSinclair%2C+P+R%3BGorman%2C+N%3BSinclair%2C+J+F&rft.aulast=Lambrecht&rft.aufirst=R&rft.date=1992-05-01&rft.volume=294&rft.issue=2&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-15 N1 - Date created - 1992-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Central thyrotropin-releasing factor analog prevents ethanol-induced gastric damage through prostaglandins in rats. AN - 72907697; 1568566 AB - The effects of intracisternal injection of the stable thyrotropin-releasing factor (TRH) analog RX 77368 on gastric lesions induced by 60% ethanol and gastric prostaglandin E2 (PGE2) release were studied in rats. RX 77368 (1.0 and 1.5 ng) injected intracisternally inhibited (by 58% and 78%, respectively) macroscopic gastric damage induced by ethanol. Higher doses (3 and 300 ng) inhibited ethanol-induced gastric injury only in rats pretreated with omeprazole (20 mg/kg SC). Gastric acid output measured in conscious rats 2 hours after pylorus ligation was not modified by intracisternal injection of RX 77368 at 1.5 ng but was significantly increased by 54% at the 3-ng dose. The protective effect of TRH analog (1.5 ng) was completely abolished by indomethacin (5 mg/kg IP) and atropine (2 mg/kg SC) pretreatment. In pylorus-ligated rats, intracisternal RX 77368 (1.5 ng) inhibited ethanol-induced gastric lesions by 64%. Intracisternal injection of RX 77368 (1.5 ng) increased PGE2 levels measured in the effluent of dialysis fibers implanted into the corpus submucosa of urethane-anesthetized rats. Peripheral administration of omeprazole, atropine, indomethacin, or RX 77368 (1.5 ng IV) did not influence gastric damage induced by ethanol. These data show that the stable TRH analog, RX 77368, injected intracisternally at low non-secretory doses acts in the brain to protect against ethanol lesions through prostaglandin and cholinergic pathways. These findings suggest that central vagal activation induced by TRH may play a role in the control of mucosal integrity against ethanol through cholinergic prostaglandin release. JF - Gastroenterology AU - Yoneda, M AU - Taché, Y AD - Center for Ulcer Research and Education, Veterans Administration Medical Center, Los Angeles, California. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 1568 EP - 1574 VL - 102 IS - 5 SN - 0016-5085, 0016-5085 KW - Ethanol KW - 3K9958V90M KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide KW - 76820-40-1 KW - Dinoprostone KW - K7Q1JQR04M KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Vagus Nerve -- physiology KW - Vagus Nerve -- drug effects KW - Pyrrolidonecarboxylic Acid -- analogs & derivatives KW - Male KW - Gastric Acid -- secretion KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Thyrotropin-Releasing Hormone -- analogs & derivatives KW - Brain -- drug effects KW - Ethanol -- toxicity KW - Dinoprostone -- secretion KW - Gastric Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72907697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Central+thyrotropin-releasing+factor+analog+prevents+ethanol-induced+gastric+damage+through+prostaglandins+in+rats.&rft.au=Yoneda%2C+M%3BTach%C3%A9%2C+Y&rft.aulast=Yoneda&rft.aufirst=M&rft.date=1992-05-01&rft.volume=102&rft.issue=5&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-27 N1 - Date created - 1992-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells. AN - 72907679; 1569190 AB - Colo 320 cells are colonic carcinoma cells known to express abundant c-myc mRNA. Based on the response of several hematopoietic cell lines to chemical inducers of differentiation, we reasoned that such agents might have similar inductive activity in Colo 320 cells. Accordingly, we exposed Colo 320 cells to 5 mM sodium butyrate (NaBT) for 7 d. C-myc expression decreased threefold and self-replicative potential decreased (defined as a greater than 60% decrease in colony-forming capacity in soft agar that did not contain inducer). In an effort to demonstrate a direct cause and effect between myc expression and the colony-forming capacity of Colo 320 cells, we exposed these cells to a 15-base antisense c-myc oligonucleotide (complementary to the translation initiation region of exon II). Cells were also exposed to equimolar (20 microM) amounts of sense and missense oligonucleotides. Subsequently, cells were incubated at 10, 20, 30, and 40 microM antisense DNA for 16 h, then washed and plated in oligonucleotide-free agar medium. We demonstrated that: (a) the oligomers were stable in the extracellular medium and in the cell cytoplasm; (b) the uptake of the oligonucleotides was 0.7%; (c) sense and missense oligonucleotides had no effect on colony-forming capacity; and (d) the antisense c-myc oligonucleotide resulted in a 40-75% concentration-dependent decrease in colony-forming capacity. The specific inhibition of colony-forming capacity by antisense DNA suggests that the role of myc expression in Colo 320 cells is similar to its role in hematopoiesis, and that the failure to inhibit myc expression maintains colony-forming capacity. This system provides a new strategy for inducing differentiation and may provide further insight into the genetic factors that govern the process of colonic carcinogenesis. JF - The Journal of clinical investigation AU - Collins, J F AU - Herman, P AU - Schuch, C AU - Bagby, G C AD - Department of Medicine, Portland Veterans Administration Medical Center, Oregon 97207. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 1523 EP - 1527 VL - 89 IS - 5 SN - 0021-9738, 0021-9738 KW - Butyrates KW - 0 KW - Oligonucleotides, Antisense KW - RNA, Messenger KW - Butyric Acid KW - 107-92-6 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Tumor Cells, Cultured KW - Humans KW - Butyrates -- pharmacology KW - In Vitro Techniques KW - RNA, Messenger -- genetics KW - Cell Differentiation -- drug effects KW - Cell Division KW - Colonic Neoplasms -- genetics KW - Carcinoma -- pathology KW - Genes, myc KW - Colonic Neoplasms -- pathology KW - Carcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72907679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=c-myc+antisense+oligonucleotides+inhibit+the+colony-forming+capacity+of+Colo+320+colonic+carcinoma+cells.&rft.au=Collins%2C+J+F%3BHerman%2C+P%3BSchuch%2C+C%3BBagby%2C+G+C&rft.aulast=Collins&rft.aufirst=J&rft.date=1992-05-01&rft.volume=89&rft.issue=5&rft.spage=1523&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-26 N1 - Date created - 1992-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 [6159641] J Biol Chem. 1987 Jan 25;262(3):1092-7 [3805014] Cancer Res. 1982 Mar;42(3):1052-8 [7059970] Cancer. 1980 Mar 15;45(5 Suppl):1178-84 [7357510] Cancer. 1980 Mar 15;45(5 Suppl):1238-42 [7357515] Histopathology. 1990 Apr;16(4):357-63 [1694512] Hum Pathol. 1987 Jan;18(1):9-21 [2434408] Lab Invest. 1985 Mar;52(3):243-56 [2579289] Biotechniques. 1988 Feb;6(2):114-6 [2908499] Gastroenterol Clin North Am. 1988 Dec;17(4):931-40 [3068151] Proc Natl Acad Sci U S A. 1988 Feb;85(4):1028-32 [3277186] Mol Cell Biol. 1988 Feb;8(2):963-73 [3280975] J Clin Invest. 1986 Jan;77(1):271-8 [3511091] Proc Natl Acad Sci U S A. 1986 Sep;83(17):6480-4 [3529085] Cancer Res. 1985 Feb;45(2):822-5 [3855381] Br J Haematol. 1986 Feb;62(2):287-92 [3947550] Am J Clin Pathol. 1981 Apr;75(4):581-4 [6261578] Am J Surg Pathol. 1983 Oct;7(7):643-51 [6314828] Mol Cell Biol. 1983 May;3(5):787-95 [6865942] Cancer Res. 1982 Nov;42(11):4540-5 [7127294] Cancer. 1980 Mar 15;45(5 Suppl):1185-92 [7357511] Arch Biochem Biophys. 1962 Mar;96:506-15 [13906951] Cancer Res. 1979 Dec;39(12):4914-24 [498117] Cell. 1991 May 31;65(5):715-6 [2040011] Cancer. 1988 Apr 1;61(7):1359-63 [2449944] Annu Rev Genet. 1986;20:361-84 [3028245] Int J Cancer. 1988 Jul 15;42(1):64-70 [3164710] Blood. 1987 Nov;70(5):1233-44 [3311197] Nature. 1986 Aug 21-27;322(6081):748-50 [3528861] Proc Natl Acad Sci U S A. 1983 Mar;80(6):1707-11 [6300869] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Does irradiation produce irreversible changes in canine jejunal myoelectric activity? AN - 72897797; 1563313 AB - We sought to determine whether acute irradiation-induced changes in jejunal myoelectric activity are reversible or chronic and progressive with repeated exposures. Five dogs underwent abdominal irradiation absorbing 938 cGy on four separate occasions, two weeks apart. Recordings of jejunal myoelectric activity were made before and 10-11 days after each irradiation exposure. Ten to 11 days after the first exposure, the animals recovered completely from the acute radiation syndrome, and the myoelectric activity returned to normal. After subsequent exposures, they developed chronic diarrhea, profound weight loss, and progressive changes in myoelectric activity. Slow waves exhibited highly variable configuration, had an irregular rhythm, and were frequently uncoupled. Spike burst activity, duration, and length of migration were reduced in association with abnormal motility patterns even though histologic abnormalities were mild. Such changes are likely to interfere with normal propulsion and contribute to impaired nutrition. The abnormalities suggest that irradiation causes dysfunction of one or more of the cellular elements involved in small bowel motility (muscle, nerve, and interstitial cells) prior to the development of severe histologic abnormalities or mechanical obstruction. JF - Digestive diseases and sciences AU - Summers, R W AU - Glenn, C E AU - Flatt, A J AU - Elahmady, A AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 716 EP - 722 VL - 37 IS - 5 SN - 0163-2116, 0163-2116 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Action Potentials -- physiology KW - Gastrointestinal Motility -- radiation effects KW - Gastrointestinal Motility -- physiology KW - Action Potentials -- radiation effects KW - Dogs KW - Dose-Response Relationship, Radiation KW - Radiation Injuries, Experimental -- physiopathology KW - Time Factors KW - Female KW - Myoelectric Complex, Migrating -- radiation effects KW - Jejunum -- radiation effects KW - Myoelectric Complex, Migrating -- physiology KW - Jejunum -- physiopathology KW - Muscle, Smooth -- radiation effects KW - Muscle, Smooth -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72897797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Does+irradiation+produce+irreversible+changes+in+canine+jejunal+myoelectric+activity%3F&rft.au=Summers%2C+R+W%3BGlenn%2C+C+E%3BFlatt%2C+A+J%3BElahmady%2C+A&rft.aulast=Summers&rft.aufirst=R&rft.date=1992-05-01&rft.volume=37&rft.issue=5&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-20 N1 - Date created - 1992-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bromocriptine treatment of nonfluent aphasia. AN - 85225352; pmid-1554312 AB - Two patients with nonfluent aphasia, secondary to stroke, of more than 18 months' duration, were started on bromocriptine to determine its effect on speech fluency. The first patient showed some improvement in fluency at 10 mg and marked improvement at 30 mg; he increased from a mean length of 3.19 words to 4.23 words per utterance. The second patient improved at 10 mg, got worse at 30 mg, and improved again at 10 mg; he increased again to 4.44 at 10 mg. Functionally, both of the patients, their families, and the hospital staff noticed marked improvement in producing multisyllable words and providing information in sentence form. Our results suggest that bromocriptine may be useful for improving fluency in some chronically nonfluent aphasic patients and that the optimum dose may vary from person to person. JF - Archives of Physical Medicine and Rehabilitation AU - Gupta, S R AU - Mlcoch, A G AD - Department of Neurology, Veterans Administration Hospital, Hines, IL 60141. PY - 1992 SP - 373 EP - 376 VL - 73 IS - 4 SN - 0003-9993, 0003-9993 KW - Language Tests KW - Bromocriptine KW - Cerebral Infarction KW - Dose-Response Relationship, Drug KW - Aphasia, Broca KW - Human KW - Speech Therapy KW - Aged KW - Middle Age KW - Case Report KW - Speech KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Bromocriptine+treatment+of+nonfluent+aphasia.&rft.au=Gupta%2C+S+R%3BMlcoch%2C+A+G&rft.aulast=Gupta&rft.aufirst=S&rft.date=1992-04-01&rft.volume=73&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - One more look at alcohol consumption and risk of coronary disease. AN - 72960417; 1590558 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Peña, J M AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 350 VL - 16 IS - 2 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Myocardial Infarction -- mortality KW - Coronary Disease -- mortality KW - Alcohol Drinking -- mortality KW - Alcoholism -- mortality KW - Alcohol Drinking -- adverse effects KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72960417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=One+more+look+at+alcohol+consumption+and+risk+of+coronary+disease.&rft.au=Gallant%2C+D+M%3BPe%C3%B1a%2C+J+M&rft.aulast=Gallant&rft.aufirst=D&rft.date=1992-04-01&rft.volume=16&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-22 N1 - Date created - 1992-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. AN - 72959927; 1592437 AB - Most research on the effects of ageing on gut mucosal immunity has been performed using rodents. However, there are inherent difficulties in the extrapolation of rodent data to humans. This study was initiated to define age-related changes in the gastrointestinal (GI) mucosal immune response in non-human primates. Antibody responses were measured in young and old rhesus monkeys (Macaca mulatta) immunized intraduodenally with cholera toxin (Ctx)/cholera toxoid (Ctd). Antigen-specific immunoglobulin A (IgA) antibody levels were markedly lower while anti-Ctx IgG and IgM titres were higher in the intestinal lavage samples of old as compared to young animals. Total IgA concentrations in gut lavage were independent of age or immune status. Measurable titres of anti-Ctx IgA in the saliva of both age groups support the common mucosal immune hypothesis. Flow cytometric analysis was used to identify age-related shifts in the expression of cell surface antigens on peripheral blood lymphocytes. The relative number of both IgA+ and Ctx+ cells was dramatically reduced in the blood of old monkeys. Collectively, these data suggest that the GI mucosal immune response to Ctx is compromised in old rhesus macaques. The deficit in immune responsiveness, namely reduced anti-Ctx IgA antibody secretion into the intestinal lumen, may be a consequence of alterations in the process of maturation and homing of specific antibody-secreting B lymphocytes. JF - Immunology AU - Taylor, L D AU - Daniels, C K AU - Schmucker, D L AD - Cell Biology and Aging, Veterans Administration Medical Center, University of California, San Francisco 94121. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 614 EP - 618 VL - 75 IS - 4 SN - 0019-2805, 0019-2805 KW - Antigens, Surface KW - 0 KW - Immunoglobulin A KW - Immunoglobulin G KW - Immunoglobulin M KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Saliva -- immunology KW - Animals KW - Cholera Toxin -- immunology KW - Macaca mulatta KW - Immunoglobulin M -- biosynthesis KW - Immunoglobulin G -- biosynthesis KW - Male KW - Female KW - Antigens, Surface -- analysis KW - Intestinal Mucosa -- immunology KW - Intestinal Mucosa -- metabolism KW - Immunoglobulin A -- biosynthesis KW - Aging -- immunology KW - Immunoglobulin A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72959927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Ageing+compromises+gastrointestinal+mucosal+immune+response+in+the+rhesus+monkey.&rft.au=Taylor%2C+L+D%3BDaniels%2C+C+K%3BSchmucker%2C+D+L&rft.aulast=Taylor&rft.aufirst=L&rft.date=1992-04-01&rft.volume=75&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-02 N1 - Date created - 1992-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunology. 1988 Aug;64(4):691-5 [3169843] J Immunol. 1973 Aug;111(2):395-403 [4197984] Gastroenterology. 1988 Jun;94(6):1432-40 [3360264] Methods Enzymol. 1984;108:88-102 [6527662] J Am Geriatr Soc. 1986 May;34(5):377-84 [3514735] Proc Natl Acad Sci U S A. 1987 Apr;84(8):2449-53 [3470804] Hepatology. 1987 May-Jun;7(3):517-21 [3570162] Immunology. 1985 Oct;56(2):345-50 [4054945] J Immunol. 1985 Jun;134(6):3855-8 [3989300] Gastroenterology. 1985 Feb;88(2):436-43 [3965333] Adv Immunol. 1980;29:287-330 [6998260] J Immunol. 1978 Nov;121(5):1773-80 [309481] J Immunol. 1979 May;122(5):1892-8 [448111] Infect Immun. 1976 Jun;13(6):1692-8 [823107] J Immunol Methods. 1976;13(3-4):215-26 [796385] Ciba Found Symp. 1976;(42):129-47 [1086763] Eur J Immunol. 1974 Oct;4(10):701-4 [4214705] J Immunol Methods. 1988 May 25;110(1):85-91 [3373004] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Total skin electron beam radiation therapy for mycosis fungoides. AN - 72866889; 1553898 AB - Forty-nine patients with biopsy-proven mycosis fungoides, Stages I-IV were treated using total skin electron beam irradiation (TSEBI). Total dose ranged from 600 cGy to 3,200 cGy. To evaluate the dose response relationship, patients were retrospectively divided into two groups. In Group I, 18 patients received a dose of 2,000 cGy or less, and in Group II, 31 patients received more than 2,000 cGy. The overall response rate was 87.7% with a 75.7% complete response and 12.2% partial response. Complete response was higher among patients with early stage disease: (Stage IA 1/1, Stage IB 23/35 (92%), Stage IIA 3/4 (75%), Stage IIB 4/8 (50%), Stage III 3/6 (50%), Stage IVA 1/1, Stage IVB 0/1, and unstaged group 2/3 (66.6%)). Patients treated with a higher total dose had a higher overall 5-year survival rate (Group I 38%, Group II 68%), longer median duration of complete response (Group I, 27 months; Group II, 35.3 months), slightly better complete response rate (72.2% for Group I, 77.4% for Group II), and lower recurrence rate (Group I, 94%; Group II, 83.9%) compared to patients with lower total dose. Complications from TSEBI were minimal. Total skin electron beam irradiation is effective in controlling early stage mycosis fungoides; however, a prospective study to evaluate optimum total dose is needed. JF - American journal of clinical oncology AU - Reddy, S AU - Parker, C M AU - Shidnia, H AU - Gaffney, M G AU - Blyton, B D AU - Pruner, L M AU - Kalasinski, L A AD - Department of Radiation Oncology, Richard L. Roudebush Veterans Administration Medical Center/Indiana University Medical Center, Indianapolis 46202. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 119 EP - 124 VL - 15 IS - 2 SN - 0277-3732, 0277-3732 KW - Index Medicus KW - Neoplasm Staging KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Survival Analysis KW - Radiotherapy, High-Energy -- adverse effects KW - Mycosis Fungoides -- radiotherapy KW - Skin Neoplasms -- radiotherapy KW - Skin Neoplasms -- pathology KW - Radiotherapy, High-Energy -- methods KW - Mycosis Fungoides -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72866889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=Total+skin+electron+beam+radiation+therapy+for+mycosis+fungoides.&rft.au=Reddy%2C+S%3BParker%2C+C+M%3BShidnia%2C+H%3BGaffney%2C+M+G%3BBlyton%2C+B+D%3BPruner%2C+L+M%3BKalasinski%2C+L+A&rft.aulast=Reddy&rft.aufirst=S&rft.date=1992-04-01&rft.volume=15&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-29 N1 - Date created - 1992-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. AN - 72848893; 1548084 AB - Listeria monocytogenes strains previously generated by transposon mutagenesis were examined with respect to virulence and induction of protective immunity in BALB/c mice. The phenotypic defects observed in these mutant L. monocytogenes strains included decreased hemolysin (listeriolysin O [LLO]) production, phospholipase C activity, intracellular growth, and/or cell-to-cell spread in vitro. While 50% lethal dose determinations performed with these mutant strains indicated reduced virulence for BALB/c mice, sublethal infection with the majority of these mutant strains provided protection against a subsequent challenge with the fully virulent L. monocytogenes parent strain. In addition, in vitro infection of the J774 cell line with most of these mutant strains converted these phagocytic cells to targets of L. monocytogenes-immune cytotoxic cells. The exceptions to these findings were two LLO-negative, avirulent mutant strains which were unable to immunize mice against a secondary challenge with virulent L. monocytogenes. One of these mutants contained a transposon insertion within the structural gene for LLO, and the other contained a transposon insertion in the structural gene for the transcriptional activator of the LLO gene. These two LLO-negative mutant strains also were unable to escape phagolysosomes in infected J774 cells and could not transform these phagocytic cells into targets of L. monocytogenes-immune cytotoxic cells. These findings confirm the importance of LLO in the induction of antilisterial immunity and suggest that a cytoplasmic localization of these pathogenic bacteria is required for the development of protective immunity. JF - Infection and immunity AU - Barry, R A AU - Bouwer, H G AU - Portnoy, D A AU - Hinrichs, D J AD - Immunology Research, Veterans Administration Medical Center, Portland, Oregon 97207. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 1625 EP - 1632 VL - 60 IS - 4 SN - 0019-9567, 0019-9567 KW - Antibodies, Bacterial KW - 0 KW - Bacterial Toxins KW - Heat-Shock Proteins KW - Hemolysin Proteins KW - hlyA protein, Listeria monocytogenes KW - 72270-41-8 KW - Phospholipases KW - EC 3.1.- KW - Index Medicus KW - Animals KW - Listeriosis -- prevention & control KW - Antibodies, Bacterial -- immunology KW - Heat-Shock Proteins -- physiology KW - Mice KW - Mice, Inbred BALB C KW - Vaccination KW - Virulence KW - Lethal Dose 50 KW - Cytotoxicity Tests, Immunologic KW - Phagosomes -- physiology KW - Antibodies, Bacterial -- biosynthesis KW - Colony-Forming Units Assay KW - Phospholipases -- biosynthesis KW - Female KW - Cell Division KW - Listeria monocytogenes -- pathogenicity KW - Listeria monocytogenes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72848893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Pathogenicity+and+immunogenicity+of+Listeria+monocytogenes+small-plaque+mutants+defective+for+intracellular+growth+and+cell-to-cell+spread.&rft.au=Barry%2C+R+A%3BBouwer%2C+H+G%3BPortnoy%2C+D+A%3BHinrichs%2C+D+J&rft.aulast=Barry&rft.aufirst=R&rft.date=1992-04-01&rft.volume=60&rft.issue=4&rft.spage=1625&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-23 N1 - Date created - 1992-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1990 Apr;58(4):1048-58 [2108086] Infect Immun. 1990 Mar;58(3):654-8 [2106491] J Immunol. 1990 Dec 1;145(11):3540-6 [2147195] Clin Invest Med. 1984;7(4):303-9 [6442653] Rev Infect Dis. 1981 Nov-Dec;3(6):1221-50 [6805064] J Immunol. 1957 Apr;78(4):262-8 [13429097] J Exp Med. 1962 Sep 1;116:381-406 [14467923] J Cell Biol. 1989 Oct;109(4 Pt 1):1597-608 [2507553] Infect Immun. 1989 Nov;57(11):3629-36 [2509366] Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S650-9 [2961041] J Bacteriol. 1987 Mar;169(3):1291-7 [3029033] Infect Immun. 1986 May;52(2):401-7 [3084382] J Immunol. 1987 Apr 1;138(7):2266-71 [3104455] J Immunol. 1987 Aug 15;139(4):1104-7 [3112223] J Immunol. 1987 Sep 15;139(6):2005-9 [3114382] Infect Immun. 1987 Nov;55(11):2822-9 [3117693] Microb Pathog. 1986 Jun;1(3):249-60 [3150026] Immunology. 1985 Sep;56(1):33-42 [3876276] Infect Immun. 1985 Apr;48(1):263-6 [3920148] Infect Immun. 1974 Sep;10(3):489-98 [4214773] J Exp Med. 1969 May 1;129(5):993-1012 [4976111] Eur J Immunol. 1983 Mar;13(3):265-8 [6403361] Infect Immun. 1983 Mar;39(3):1208-13 [6404821] J Exp Med. 1979 Oct 1;150(4):1033-8 [117073] J Exp Med. 1991 Mar 1;173(3):751-4 [1847723] Nature. 1990 May 10;345(6271):175-6 [2110628] Proc Natl Acad Sci U S A. 1990 Nov;87(21):8336-40 [2122460] Infect Immun. 1990 Nov;58(11):3770-8 [2172168] J Exp Med. 1988 Apr 1;167(4):1459-71 [2833557] Infect Immun. 1986 Apr;52(1):50-5 [3007363] J Exp Med. 1986 Jul 1;164(1):363-8 [3088201] Infect Immun. 1987 Jul;55(7):1641-6 [3110067] Infect Immun. 1987 Sep;55(9):2300-3 [3114151] J Immunol. 1988 May 1;140(9):3173-9 [3129513] Immunology. 1987 Feb;60(2):287-93 [3493210] J Exp Med. 1973 Aug 1;138(2):342-55 [4198199] J Exp Med. 1972 May 1;135(5):1104-12 [4623315] Nature. 1982 May 20;297(5863):233-4 [6176874] Infect Immun. 1984 Oct;46(1):111-5 [6434424] Infect Immun. 1984 Jul;45(1):234-41 [6610639] J Exp Med. 1964 Jul 1;120:93-103 [14194395] Infect Immun. 1992 Apr;60(4):1263-7 [1312514] Mol Microbiol. 1991 Sep;5(9):2273-83 [1662763] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6068-72 [2117270] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychodynamic Group Treatment of Posttraumatic Stress Disorder in Vietnam Veterans AN - 61337830; 9306694 AB - Intrapsychic & interpersonal issues associated with combat exposure need to be addressed in treating Vietnam veterans suffering from posttraumatic stress disorder (PTSD). Group therapy is proposed as a core treatment for dealing with the loneliness, guilt, & helplessness of veterans with PTSD. A model is proposed in which patients are treated for 1+ year in weekly groups that meet for 16-week sequential segments. Clinical guidelines are made explicit to new members by the cotherapists. Discussion topics deal with traumatic experiences related to combat with important pre- & postwar issues relevant to the symptoms of PTSD. Timely integration & working through of these issues in the group is critical. 39 References. Adapted from the source document. JF - International Journal of Group Psychotherapy AU - Koller, Paul AU - Marmar, Charles R AU - Kanas, Nick AD - Post-Traumatic Stress Disorder Program Veterans Administration Medical Center, 4150 Clement St San Francisco CA 94121 Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 225 EP - 246 VL - 42 IS - 2 SN - 0020-7284, 0020-7284 KW - posttraumatic stress disorder, intrapsychic/interpersonal issues, Vietnam veterans' group therapy KW - Veterans KW - Vietnam War KW - Interpersonal Relations KW - Group Therapy KW - Posttraumatic Stress Disorder KW - Treatment Methods KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61337830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Group+Psychotherapy&rft.atitle=Psychodynamic+Group+Treatment+of+Posttraumatic+Stress+Disorder+in+Vietnam+Veterans&rft.au=Koller%2C+Paul%3BMarmar%2C+Charles+R%3BKanas%2C+Nick&rft.aulast=Koller&rft.aufirst=Paul&rft.date=1992-04-01&rft.volume=42&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Group+Psychotherapy&rft.issn=00207284&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJGPAO N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Treatment Methods; Interpersonal Relations; Veterans; Vietnam War; Group Therapy ER - TY - JOUR T1 - Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment. AN - 72863311; 1556130 AB - The relationship between maturation of lipoprotein lipase (LPL) and its translocation from the endoplasmic reticulum (ER) to the Golgi complex was determined by measuring lipolytic activity under conditions preventing transport of the enzyme from the ER to the Golgi compartment. In the presence of brefeldin A, a reagent that inhibits movement of proteins from the ER and causes the disassembly of the Golgi complex, pro-5 Chinese hamster ovary cells accumulated catalytically active LPL, while secretion of the enzyme was effectively blocked. LPL retained intracellularly by brefeldin A treatment possessed oligosaccharide chains that were processed to the complex form by the Golgi enzymes redistributed into the ER. At 16 degrees C, a condition disrupting protein transport to the cis-Golgi, the retained enzyme again remained catalytically active although the oligosaccharides remained in the high mannose form. Lastly, attachment of the specific ER retention signal KDEL (Lys-Asp-Glu-Leu) to the carboxyl terminus of LPL also resulted in intracellularly retained enzyme that was fully active. The importance of oligosaccharide processing for attainment of LPL catalytic activity in vitro was also determined. LPL was active and secreted when trimming of the mannose residues was inhibited by deoxymannojirimycin and when addition of complex sugars was blocked using Chinese hamster ovary mutants (lec1 and lec2), indicating that these processing events are not necessary for the expression of a functional enzyme. However, blocking glucose removal by glucosidase inhibitors (castanospermine and N-methyl-deoxynojirimycin) resulted in a significant reduction in LPL specific activity and secretion. Thus, glucose trimming of LPL oligosaccharides is essential for enzyme activation; however, further oligosaccharide processing or translocation of the enzyme to the cis-Golgi is not required for full expression of lipolytic activity in vitro. JF - The Journal of biological chemistry AU - Ben-Zeev, O AU - Doolittle, M H AU - Davis, R C AU - Elovson, J AU - Schotz, M C AD - Lipid Research, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1992/03/25/ PY - 1992 DA - 1992 Mar 25 SP - 6219 EP - 6227 VL - 267 IS - 9 SN - 0021-9258, 0021-9258 KW - Anti-Bacterial Agents KW - 0 KW - Cyclopentanes KW - Brefeldin A KW - 20350-15-6 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Animals KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Amino Acid Sequence KW - Glycosylation KW - Models, Biological KW - Mutagenesis KW - Cloning, Molecular KW - Base Sequence KW - Blotting, Western KW - Cyclopentanes -- pharmacology KW - Transfection KW - Kinetics KW - Genetic Vectors KW - Restriction Mapping KW - Molecular Sequence Data KW - CHO Cells KW - Cricetinae KW - Endoplasmic Reticulum -- enzymology KW - Lipoprotein Lipase -- biosynthesis KW - Golgi Apparatus -- enzymology KW - Lipoprotein Lipase -- metabolism KW - Lipoprotein Lipase -- genetics KW - Protein Processing, Post-Translational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72863311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Maturation+of+lipoprotein+lipase.+Expression+of+full+catalytic+activity+requires+glucose+trimming+but+not+translocation+to+the+cis-Golgi+compartment.&rft.au=Ben-Zeev%2C+O%3BDoolittle%2C+M+H%3BDavis%2C+R+C%3BElovson%2C+J%3BSchotz%2C+M+C&rft.aulast=Ben-Zeev&rft.aufirst=O&rft.date=1992-03-25&rft.volume=267&rft.issue=9&rft.spage=6219&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - [3Fe-4S] to [4Fe-4S] cluster conversion in Escherichia coli fumarate reductase by site-directed mutagenesis. AN - 72836570; 1312345 AB - Site-directed mutants of Escherichia coli fumarate reductase in which FrdB Cys204, Cys210, and Cys214 were individually replaced by Ser and in which Val207 was replaced by Cys were constructed and overexpressed in a strain of E. coli lacking a wild-type copy of fumarate reductase and succinate dehydrogenase. The consequences of these mutations on bacterial growth, enzymatic activity, and the EPR properties of the constituent iron-sulfur clusters were investigated. The FrdB Cys204Ser, Cys210Ser, and Cys214Ser mutations result in enzymes with negligible activity that have dissociated from the membrane and consequently are incapable of supporting cell growth under conditions requiring a functional fumarate reductase. EPR studies indicate that these effects are associated with loss of both the [3Fe-4S] and [4Fe-4S] clusters, centers 3 and 2, respectively. In contrast, the FrdB Val207Cys mutation results in a functional membrane-bound enzyme that is able to support growth under anaerobic and aerobic conditions. However, EPR studies indicate that the indigenous [3Fe-4S]+,0 cluster (Em = -70 mV), center 3, has been replaced by a much lower potential [4Fe-4S]2+,+ cluster (Em = -350 mV), indicating that the primary sequence of the polypeptide determines the type of clusters assembled. The results of these studies afford new insights into the role of centers 2 and 3 in mediating electron transfer from menaquinol, the residues that ligate these clusters, and the intercluster magnetic interactions in the wild-type enzyme. JF - Biochemistry AU - Manodori, A AU - Cecchini, G AU - Schröder, I AU - Gunsalus, R P AU - Werth, M T AU - Johnson, M K AD - Molecular Biology Division, Veterans Administration medical Center, San Francisco, California 94121. Y1 - 1992/03/17/ PY - 1992 DA - 1992 Mar 17 SP - 2703 EP - 2712 VL - 31 IS - 10 SN - 0006-2960, 0006-2960 KW - frdABCD KW - kan KW - sdhcDAB KW - Iron-Sulfur Proteins KW - 0 KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Index Medicus KW - Oxidation-Reduction KW - Sequence Homology, Nucleic Acid KW - Electron Spin Resonance Spectroscopy KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Plasmids KW - Mutation KW - Catalysis KW - Mutagenesis, Site-Directed KW - Succinate Dehydrogenase -- genetics KW - Iron-Sulfur Proteins -- genetics KW - Escherichia coli -- enzymology KW - Escherichia coli -- growth & development KW - Iron-Sulfur Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72836570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=%5B3Fe-4S%5D+to+%5B4Fe-4S%5D+cluster+conversion+in+Escherichia+coli+fumarate+reductase+by+site-directed+mutagenesis.&rft.au=Manodori%2C+A%3BCecchini%2C+G%3BSchr%C3%B6der%2C+I%3BGunsalus%2C+R+P%3BWerth%2C+M+T%3BJohnson%2C+M+K&rft.aulast=Manodori&rft.aufirst=A&rft.date=1992-03-17&rft.volume=31&rft.issue=10&rft.spage=2703&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-22 N1 - Date created - 1992-04-22 N1 - Date revised - 2017-01-13 N1 - Gene symbol - frdABCD; kan; sdhcDAB N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethanol and human saliva: effect of chronic alcoholism on flow rate, composition, and epidermal growth factor. AN - 85229652; pmid-1371639 AB - Parotid saliva samples from 24 alcoholic subjects without evidence of cirrhosis were analyzed for changes in flow rate, composition, and epidermal growth factor (EGF) secretion. Mean (+/- SE) stimulated parotid saliva flow rate (ml/min/gland) was significantly (p less than 0.01) lower in alcoholic subjects than in matched control subjects. Reduction in parotid saliva flow rate was associated with significant (p less than 0.05) decrease in total protein and amylase secretion in this group of patients. In addition, secretion of immunoreactive EGF, a specific salivary protein, was also markedly reduced (p less than 0.05) in alcoholic patients. None of the parotid saliva samples from the alcoholic subjects had detectable bioactivity of EGF in saliva. These data suggest that chronic alcohol ingestion is associated with significant changes in parotid saliva secretion and its composition, which may perpetuate and compound ethanol-induced injury to the upper gastrointestinal tract. JF - The American Journal of Gastroenterology AU - Dutta, S K AU - Orestes, M AU - Vengulekur, S AU - Kwo, P AD - Veterans Administration Medical Center, Baltimore, Maryland. PY - 1992 SP - 350 EP - 354 VL - 87 IS - 3 SN - 0002-9270, 0002-9270 KW - Electrolytes KW - Epidermal Growth Factor KW - Human KW - Adult KW - Alcoholism KW - Amylases KW - Middle Age KW - Saliva KW - Parotid Gland KW - Radioimmunoassay KW - Male KW - Salivary Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85229652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Ethanol+and+human+saliva%3A+effect+of+chronic+alcoholism+on+flow+rate%2C+composition%2C+and+epidermal+growth+factor.&rft.au=Dutta%2C+S+K%3BOrestes%2C+M%3BVengulekur%2C+S%3BKwo%2C+P&rft.aulast=Dutta&rft.aufirst=S&rft.date=1992-03-01&rft.volume=87&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of bovine serum albumin on the extent of ortho rearrangement of N-(sulfooxy)-2-fluorenylacetamide and of enzymatically activated N-hydroxy-2-fluorenylacetamide and on the binding of reactive esters to nucleic acids. AN - 73099930; 1643258 AB - We have investigated the effect of the bovine serum albumin (BSA)-catalyzed ortho rearrangement of synthetic and enzymatically generated N-(sulfooxy)-2-fluorenylacetamide (NSF) to the O-sulfate esters on the binding of NSF to transfer ribonucleic acid (tRNA) and to deoxyribonucleic acid (DNA). Binding of synthetic NSF to tRNA and DNA decreased approximately 90 and 70%, respectively, in the presence of BSA. Under these conditions, the ortho rearrangement, a minor reaction in the absence of BSA, was nearly quantitative. The decrease of adduct formation to nucleic acids was not attributable to the competitive binding of NSF to BSA. Binding of NSF, generated by cytosolic sulfonation of the arylhydroxamic acid, N-hydroxy-2-fluorenylacetamide, to tRNA, was diminished approximately 97% in the presence of BSA while the ortho rearrangement of the sulfonated substrate increased from less than 0.5% to approximately 50%. Adduct formation of DNA with N-hydroxy-2-fluorenylacetamide, activated by enzymatic sulfonation, was inhibited approximately 90% in the presence of BSA. In these experiments, the catalytic effect of BSA on the ortho rearrangement of enzymatically sulfonated N-hydroxy-2-fluorenylacetamide was of the same order as observed in the experiments with tRNA. The data obtained on the covalent interaction of DNA with enzymatically activated N-hydroxy-2-fluorenylacetamide indicate that, in addition to NSF, another electrophilic species accounts for binding of activated N-hydroxy-2-fluorenylacetamide to DNA. The data support the view that the reactive electrophile is N-acetoxy-2-fluorenamine, resulting from the N,O-transacetylation of N-hydroxy-2-fluorenylacetamide.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Kolanczyk, R C AU - Gutmann, H R AU - Rutks, I R AD - Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. PY - 1992 SP - 274 EP - 279 VL - 5 IS - 2 SN - 0893-228X, 0893-228X KW - Esters KW - 0 KW - Serum Albumin, Bovine KW - 2-acetylaminofluorene-N-sulfate KW - 16808-85-8 KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - DNA KW - 9007-49-2 KW - RNA, Transfer KW - 9014-25-9 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Esters -- chemistry KW - Cytosol -- metabolism KW - Animals KW - Liver -- metabolism KW - Male KW - Esters -- metabolism KW - RNA, Transfer -- metabolism KW - 2-Acetylaminofluorene -- metabolism KW - DNA -- metabolism KW - Serum Albumin, Bovine -- pharmacology KW - DNA -- chemistry KW - 2-Acetylaminofluorene -- analogs & derivatives KW - RNA, Transfer -- chemistry KW - 2-Acetylaminofluorene -- chemistry KW - Serum Albumin, Bovine -- chemistry KW - Hydroxyacetylaminofluorene -- metabolism KW - Hydroxyacetylaminofluorene -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73099930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Effect+of+bovine+serum+albumin+on+the+extent+of+ortho+rearrangement+of+N-%28sulfooxy%29-2-fluorenylacetamide+and+of+enzymatically+activated+N-hydroxy-2-fluorenylacetamide+and+on+the+binding+of+reactive+esters+to+nucleic+acids.&rft.au=Kolanczyk%2C+R+C%3BGutmann%2C+H+R%3BRutks%2C+I+R&rft.aulast=Kolanczyk&rft.aufirst=R&rft.date=1992-03-01&rft.volume=5&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Importance of the carboxyl terminus of human thyroid peroxidase in the efficient expression of the protein in eukaryotic cells. AN - 73087316; 1639219 AB - Carboxyl terminal truncation of membrane-associated human thyroid peroxidase (hTPO), with the elimination of its single membrane-spanning and short intracytoplasmic regions, generates a soluble, secreted, enzymatically active protein (amino acids 1-848). In order to determine the effects of further carboxyl terminal deletions on the expression of hTPO, Chinese hamster ovary cells were stably transfected with plasmids constructed to express amino acids 1-771, 1-636, 1-539 and 1-382 of the 933 amino acid TPO protein, respectively. Unlike hTPO1-848, the more severely truncated TPO mutant proteins could not be detected in conditioned media by polyclonal anti-TPO antibodies. Using detergent-solubilized microsomal proteins from these cells, very low levels of hTPO1-771 (approximately 90 kDa), but not the more extensive deletion mutations, were detected by these anti-TPO antibodies. Confirmation of the loss of efficient expression of more severely truncated hTPO was obtained using a anti-hTPO monoclonal antibody with an epitope near the amino terminus and which recognizes only the denatured protein. The mRNA for all hTPO mutants was detected in the stably-transfected Chinese hamster ovary cells. In summary, the present study indicates that a largely intact extracellular portion of hTPO is required for expression in eukaryotic cells. JF - Molecular and cellular endocrinology AU - Finke, R AU - Foti, D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans' Administration Medical Center, San Francisco, CA 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 73 EP - 78 VL - 84 IS - 1-2 SN - 0303-7207, 0303-7207 KW - RNA, Messenger KW - 0 KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Animals KW - Blotting, Western KW - Base Sequence KW - Transfection KW - Humans KW - RNA, Messenger -- analysis KW - Molecular Sequence Data KW - Precipitin Tests KW - Plasmids KW - Female KW - Cricetinae KW - Iodide Peroxidase -- biosynthesis KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73087316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Importance+of+the+carboxyl+terminus+of+human+thyroid+peroxidase+in+the+efficient+expression+of+the+protein+in+eukaryotic+cells.&rft.au=Finke%2C+R%3BFoti%2C+D%3BRapoport%2C+B&rft.aulast=Finke&rft.aufirst=R&rft.date=1992-03-01&rft.volume=84&rft.issue=1-2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-28 N1 - Date created - 1992-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies on the role of amino acids 38-45 in the expression of a functional thyrotropin receptor. AN - 72957256; 1584215 AB - We previously reported that deletion or substitution of a unique eight-amino acid tract (residues 38-45) in the extracellular domain of the human TSH receptor led to the loss of specific ligand binding to the surface of transfected cells. In the present study we analyzed this region in more detail. Using site-directed mutagenesis of the TSH receptor cDNA, we substituted amino acid residues 38-45, either in three overlapping groups of four amino acids each or individually. The resultant TSH receptor mutant cDNAs were stably transfected into Chinese hamster ovary cells, and the cells were tested for their TSH-binding ability. Our data demonstrate that amino acid residues 38-40 and 42-45 in this region of the human TSH receptor can be substituted without alteration in receptor function and are, therefore, not critical in forming or maintaining the TSH-binding site. However, substitution of Cys41, either alone or together with adjacent amino acids, leads to the loss of TSH binding to its receptor. These data suggest a central role for the amino acid in position 41 in preserving the biological function of the TSH receptor. JF - Molecular endocrinology (Baltimore, Md.) AU - Wadsworth, H L AU - Russo, D AU - Nagayama, Y AU - Chazenbalk, G D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 394 EP - 398 VL - 6 IS - 3 SN - 0888-8809, 0888-8809 KW - Receptors, Thyrotropin KW - 0 KW - Index Medicus KW - Animals KW - Base Sequence KW - Mutagenesis, Site-Directed -- genetics KW - Transfection -- genetics KW - Molecular Sequence Data KW - CHO Cells KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Cricetinae KW - Receptors, Thyrotropin -- chemistry KW - Gene Expression -- genetics KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72957256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Studies+on+the+role+of+amino+acids+38-45+in+the+expression+of+a+functional+thyrotropin+receptor.&rft.au=Wadsworth%2C+H+L%3BRusso%2C+D%3BNagayama%2C+Y%3BChazenbalk%2C+G+D%3BRapoport%2C+B&rft.aulast=Wadsworth&rft.aufirst=H&rft.date=1992-03-01&rft.volume=6&rft.issue=3&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-18 N1 - Date created - 1992-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats. AN - 72942517; 1583909 AB - Elderly patients with alcoholism often require surgery and receive nitrous oxide (N2O) as a component of their anesthetic. Since aging, ethanol, and N2O may all perturb folate and/or vitamin B12 metabolism, we examined the combined influence of these parameters on vitamin B12/folate status in a rodent model. Aged male Fischer 344 rats (24 months old) were given a liquid ethanol diet (35% of calories as ethanol) and control rats were pair-fed a liquid diet with carbohydrate substituting for the caloric content of ethanol. After receiving liquid diets for 7 weeks, rats were exposed to 60% N2O/40% 0(2) for 6 h. Urinary excretion of formic acid, formiminoglutamic acid (FIGLU), and methylmalonic acid (MMA) were used as indirect markers of folate/vitamin B12 status. In both the aged ethanol-fed and control groups, excretion of formic acid and FIGLU markedly increased the first day after N2O exposure and returned towards background values by the second day. No changes occurred in MMA excretion. Exposure to N2O decreased methionine synthase activities in liver, kidney and brain, and recovery of methionine synthase activities occurred over a period of 4 days in both the aged ethanol-fed and control groups. Ethanol treatment for 7 weeks combined with acute exposure to N2O did not deplete the aged rats of folate or vitamin B12 in blood, liver, kidney or brain. Thus, in this animal model, aging, chronic ethanol administration, and acute N2O exposure did not act synergistically to produce prolonged and severe disturbances in folate and vitamin B12 metabolism. JF - Mechanisms of ageing and development AU - Everman, B W AU - Koblin, D D AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1992/03/01/ PY - 1992 DA - 1992 Mar 01 SP - 229 EP - 243 VL - 62 IS - 3 SN - 0047-6374, 0047-6374 KW - Folic Acid KW - 935E97BOY8 KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase KW - EC 2.1.1.13 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Nitrous Oxide -- toxicity KW - Disease Models, Animal KW - Alcoholism -- metabolism KW - Male KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- metabolism KW - Aging -- metabolism KW - Folic Acid -- metabolism KW - Vitamin B 12 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72942517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=Aging%2C+chronic+administration+of+ethanol%2C+and+acute+exposure+to+nitrous+oxide%3A+effects+on+vitamin+B12+and+folate+status+in+rats.&rft.au=Everman%2C+B+W%3BKoblin%2C+D+D&rft.aulast=Everman&rft.aufirst=B&rft.date=1992-03-01&rft.volume=62&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-12 N1 - Date created - 1992-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dangerous consequences: neuroleptic-induced tardive akathisia. AN - 72930729; 1349651 JF - Journal of psychosocial nursing and mental health services AU - Blair, D T AU - Dauner, A AD - Colmery-O'Neil Veterans Administration Medical Center, Topeka, Kansas. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 41 EP - 43 VL - 30 IS - 3 SN - 0279-3695, 0279-3695 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Incidence KW - Dyskinesia, Drug-Induced -- therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72930729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=Dangerous+consequences%3A+neuroleptic-induced+tardive+akathisia.&rft.au=Blair%2C+D+T%3BDauner%2C+A&rft.aulast=Blair&rft.aufirst=D&rft.date=1992-03-01&rft.volume=30&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-10 N1 - Date created - 1992-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking. A comparison of schizophrenics with normals and substance abusing controls. AN - 72916230; 1349241 AB - The eye movements of schizophrenic patients are characterized by decreased smooth pursuit gain and an increased frequency of saccades. However, the nature of these saccades and their function during smooth pursuit has not been clearly defined. To address this issue we examined the eye movements of 22 schizophrenic patients, 20 substance abusing patients (primarily alcohol; some with concomitant cocaine and/or cannabis abuse), and 17 normal controls during a visual pursuit task using infra-red oculography. A computerized pattern recognition algorithm divided pursuit eye movements into two basic components: smooth pursuit and saccadic eye movements. The algorithm also determined eye position error and velocity error before and after each saccade. Schizophrenic patients had lower smooth pursuit gain (p less than 0.02) and made more saccades during smooth pursuit (p less than 0.02) than either comparison group. When saccades were assigned to subcategories based on direction and position error, only the frequency of 'catch-up' saccades differentiated schizophrenic patients from the comparison groups (p less than 0.05). Smooth pursuit gain was negatively correlated with saccadic frequency among all three subject groups. Eye velocity preceding saccades was significantly lower among the schizophrenic patients, but pre or post saccadic position error did not differ among the three groups. Discrete analysis of the fine structure of visual pursuit tracking may lead to a better understanding of eye movement abnormalities in schizophrenia. JF - Schizophrenia research AU - Radant, A D AU - Hommer, D W AD - Veterans Administration Medical Center, Department of Psychiatry, Seattle, WA 98108. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 225 EP - 235 VL - 6 IS - 3 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Adult KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Alcoholism -- diagnosis KW - Schizophrenia -- diagnosis KW - Schizophrenic Psychology KW - Schizophrenia -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Pursuit, Smooth -- drug effects KW - Alcoholism -- psychology KW - Saccades -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72916230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=A+quantitative+analysis+of+saccades+and+smooth+pursuit+during+visual+pursuit+tracking.+A+comparison+of+schizophrenics+with+normals+and+substance+abusing+controls.&rft.au=Radant%2C+A+D%3BHommer%2C+D+W&rft.aulast=Radant&rft.aufirst=A&rft.date=1992-03-01&rft.volume=6&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-04 N1 - Date created - 1992-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of noise bandwidth on the late-potential masking level difference. AN - 72848798; 1372230 AB - The masking level difference (MLD) is a psychoacoustic phenomenon derived from the subtraction of S pi No thresholds (signals pi radians out of phase and noise in phase at the two ears) from SoNo thresholds (signals and noise in phase at the two ears). The purpose of this study was to determine if the MLD derived from the late components (P1, N1, P2, N2) of the auditory evoked potentials was a physiological correlate of the behavioral MLD. Subjects were 15 young adults with normal hearing. Comparisons were made between behavioral and late potential thresholds to 500 Hz stimuli in So and S pi conditions in quiet, and to 500 Hz stimuli in SoNo and S pi No conditions in narrow band (50 Hz) and wide band (600 Hz) noise. No significant differences were seen for behavioral or late-potential thresholds to So and S pi conditions. The S pi No thresholds was significantly lower than the SoNo threshold, yielding an MLD for both the behavioral and physiological responses. The magnitudes of both the behavioral and late-potential MLD were larger with the narrow band noise than with the wide band noise. Evidence, therefore, is provided that the late-potential MLD reflects similar processes as are responsible for the behavioral MLD. JF - Electroencephalography and clinical neurophysiology AU - Fowler, C G AU - Mikami, C M AD - Veterans Administration Medical Center, Long Beach, CA 90822. PY - 1992 SP - 157 EP - 163 VL - 84 IS - 2 SN - 0013-4694, 0013-4694 KW - Index Medicus KW - Auditory Threshold -- physiology KW - Analysis of Variance KW - Humans KW - Electroencephalography KW - Adult KW - Acoustic Stimulation KW - Behavior -- physiology KW - Time Factors KW - Perceptual Masking -- physiology KW - Noise KW - Evoked Potentials, Auditory -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72848798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electroencephalography+and+clinical+neurophysiology&rft.atitle=Effects+of+noise+bandwidth+on+the+late-potential+masking+level+difference.&rft.au=Fowler%2C+C+G%3BMikami%2C+C+M&rft.aulast=Fowler&rft.aufirst=C&rft.date=1992-03-01&rft.volume=84&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Electroencephalography+and+clinical+neurophysiology&rft.issn=00134694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-21 N1 - Date created - 1992-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lamellar body secretory response to barrier disruption. AN - 72841060; 1545137 AB - Abundant evidence points to an important role for epidermal lamellar body secretion in permeability-barrier maintenance. However, the response of the lamellar body secretory system to barrier disruption has not been examined. Hence, we examined the lamellar body secretory response at various points after acetone-induced barrier abrogation in hairless mice in air-exposed animals and those occluded with impermeable versus vapor-permeable membranes. Tape-stripped animals served as a control for chemical toxicity. Barrier perturbation with either acetone or tape stripping was followed by rapid secretion of lamellar body contents from the uppermost granular cell layer, leaving the cytosol largely devoid of lamellar bodies. The newly secreted lamellar body contents comprised pleated sheets (not "discs," as previously thought), which unfurled in the intercellular spaces at the granular-cornified cell interface. At this time (15-30 min), the basic unit structure of the lamellar bilayers in the mid-to-upper stratum corneum appeared disorganized and interspersed with large lacunae, reflecting solvent extraction. Nascent lamellar bodies began to reappear in the granular cell cytosol by 30 min and by 360 min the cells displayed a full complement of normal-appearing lamellar bodies. Between 60 and 360 min, the density of lamellar body sheets at the granular-cornified cell interface increased, whereas the membrane bilayers of the outer stratum corneum remained disorganized. New lamellar bilayer units first appeared in the lower stratum corneum between 60 and 180 min, as a result of the transformation of secreted lamellar body sheets and over time these lamellae appeared at more apical locations. Occlusion with a water vapor-impermeable but not a vapor-permeable membrane resulted in a) decreased quantities of lamellar bodies and lamellar body-derived intercellular products; b) formation of lamellar bodies with abnormal internal contents; c) inhibition of lamellar body secretion; and d) inhibition of transformation of lamellar body-derived sheets into lamellar bilayer units. These results demonstrate the central role of the lamellar body-secretory system in barrier repair and homeostasis. JF - The Journal of investigative dermatology AU - Menon, G K AU - Feingold, K R AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 279 EP - 289 VL - 98 IS - 3 SN - 0022-202X, 0022-202X KW - Acetone KW - 1364PS73AF KW - Index Medicus KW - Permeability KW - Animals KW - Acetone -- pharmacology KW - Mice KW - Mice, Hairless KW - Epidermis -- secretion KW - Epidermis -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72841060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Lamellar+body+secretory+response+to+barrier+disruption.&rft.au=Menon%2C+G+K%3BFeingold%2C+K+R%3BElias%2C+P+M&rft.aulast=Menon&rft.aufirst=G&rft.date=1992-03-01&rft.volume=98&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-15 N1 - Date created - 1992-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A preliminary trial of beta-carotene in subjects infected with the human immunodeficiency virus. AN - 72837474; 1347316 AB - beta-Carotene is a nontoxic carotenoid with immunomodulating properties in animals and humans. Based on our observations in normal immunocompetent subjects, we studied the effects of this compound in 11 patients infected with the human immunodeficiency virus (HIV). Each subject received 60 mg of beta-carotene daily for 4 mo. Clinical and laboratory studies were obtained at baseline, every month while on treatment and for 2 mo after treatment. Increases in the percent of cells expressing Leu 11 (natural killer cells), Ia antigen and transferrin receptor (activated lymphocytes) were observed after 3 mo of treatment with beta-carotene and diminished thereafter. Major changes were not seen in total lymphocyte count or in the percent of cells expressing CD11, CD8 or CD4 antigens. No clinical toxicity was observed. These data suggest that beta-carotene can modulate certain immune markers in HIV-infected subjects. Further study of this compound in HIV infection may be warranted. JF - The Journal of nutrition AU - Garewal, H S AU - Ampel, N M AU - Watson, R R AU - Prabhala, R H AU - Dols, C L AD - Department of Internal Medicine, Tucson Veterans Administration Medical Center, AZ 85723. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 728 EP - 732 VL - 122 IS - 3 Suppl SN - 0022-3166, 0022-3166 KW - beta Carotene KW - 01YAE03M7J KW - Carotenoids KW - 36-88-4 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Skin Tests KW - CD4-Positive T-Lymphocytes -- pathology KW - CD4-Positive T-Lymphocytes -- immunology KW - Leukocyte Count KW - Lymphocyte Activation KW - Lymphocytes -- pathology KW - Drug Evaluation KW - Lymphocytes -- immunology KW - Adult KW - Middle Aged KW - Male KW - Carotenoids -- therapeutic use KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72837474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=A+preliminary+trial+of+beta-carotene+in+subjects+infected+with+the+human+immunodeficiency+virus.&rft.au=Garewal%2C+H+S%3BAmpel%2C+N+M%3BWatson%2C+R+R%3BPrabhala%2C+R+H%3BDols%2C+C+L&rft.aulast=Garewal&rft.aufirst=H&rft.date=1992-03-01&rft.volume=122&rft.issue=3+Suppl&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-06 N1 - Date created - 1992-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intragastric nicotine protects against 40% ethanol-induced gastric mucosal injury despite pretreatment with propranolol or N-ethylmaleimide in rats. AN - 72789922; 1735363 AB - We tested the hypotheses that the protective effect of intragastric nicotine against ethanol-induced gastric mucosal injury is dependent on propranolol- or N-ethylmaleimide-sensitive mechanisms. Propranolol was administered in doses (2 and 20 mg/kg) that provided dose-related blockade of beta-adrenoceptors (significant decreases in heart rate). N-Ethylmaleimide was administered in doses that previously had been shown to increase gastric vascular permeability (10 mg/kg) or inhibit gastric mucosal sulfhydryl compounds (50 mg/kg). At 0.5 hr after these or control subcutaneous pretreatments, the rats received intragastric nicotine (4 mg/kg) or vehicle. One hour later 40% ethanol was given intragastrically. The gastric corpus mucosal lesions were recorded by polaroid photographs after another hour, and their areas measured unbiasedly by computerized image analysis. The results showed that N-ethylmaleimide, but not propranolol, aggravated ethanol-induced gastric mucosal injury. The protective effect of intragastric nicotine was not modified by either pretreatment. We conclude that the mechanism mediating intragastric nicotine protection against 40% ethanol-induced gastric mucosal injury is independent of propranolol- or N-ethylmaleimide-sensitive mechanisms. JF - Digestive diseases and sciences AU - Endoh, K AU - Ro, G AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, Center for Ulcer Research and Education, UCLA School of Medicine 91343. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 391 EP - 396 VL - 37 IS - 3 SN - 0163-2116, 0163-2116 KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Propranolol KW - 9Y8NXQ24VQ KW - Ethylmaleimide KW - O3C74ACM9V KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Male KW - Stomach Diseases -- chemically induced KW - Propranolol -- pharmacology KW - Nicotine -- pharmacology KW - Premedication KW - Gastric Mucosa -- drug effects KW - Stomach Diseases -- prevention & control KW - Ethylmaleimide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+nicotine+protects+against+40%25+ethanol-induced+gastric+mucosal+injury+despite+pretreatment+with+propranolol+or+N-ethylmaleimide+in+rats.&rft.au=Endoh%2C+K%3BRo%2C+G%3BLeung%2C+F+W&rft.aulast=Endoh&rft.aufirst=K&rft.date=1992-03-01&rft.volume=37&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potentiation of IL-2-induced t-cell proliferation by retinoids. AN - 73049347; 1624219 AB - We evaluated the capacity of retinoids to potentiate proliferative responses of murine T-cells to recombinant human interleukin 2 (rIL-2). Concanavalin A (Con A) prestimulated spleen cells responded in a dose-dependent manner to added rIL-2. All-trans-retinoic acid (RA) at 10(-8) M potentiated the proliferative response by fivefold at saturating levels of IL-2. In similar experiments, two closely related retinamides, all-trans-(phenyl)retinamide (PR) and N-(4-hydroxyphenyl)retinamide (4-HPR), also potentiated murine splenocyte rIL-2 responses. Potentiation of IL-2-induced proliferation was dose-responsive to the concentration of added retinoid with peak potentiation occurring at 10(-10) - 10(-8) M in the presence of 10 U/ml rIL-2. Significant potentiation was observed at retinoid concentrations as low as 10(-14) M. Fluorescence flow cytometry of the responding cells revealed that among L3T4+, Lyt-2+ or total T-cells, at 72 h following Con A stimulation, essentially all of the cells expressed IL-2 receptors (IL-2R). This apparently represents near maximum IL-2R expression and treatment of the cells with retinoids did not increase IL-2R expression at that time point. The potentiation of IL-2 responses by retinoids was also observed with IL-2-dependent HT-2 cells, 98% of which were IL-2R positive. HT-2 proliferative responses to rIL-2 were potentiated as much as fourfold by 10(-10) M RA. HT-2 proliferative responses to rIL-2 were potentiated by all three retinoids dose dependently. Significant potentiation was observed with as little as 10(-14) M retinoid. Retinoids in the absence of IL-2 induced no proliferative responses. These data suggest that retinoids can augment the capacity of IL-2 to induce T-cell proliferation using Con A-activated murine splenic T-cell blasts and a long-term-cultured T-cell line. JF - International journal of immunopharmacology AU - Jiang, X L AU - Dillehay, D L AU - Everson, M P AU - Tilden, A B AU - Lamon, E W AD - Birmingham Veterans Administration Medical Center, AL. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 195 EP - 204 VL - 14 IS - 2 SN - 0192-0561, 0192-0561 KW - Interleukin-2 KW - 0 KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Interleukin-4 KW - 207137-56-2 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Receptors, Interleukin-2 -- analysis KW - Cells, Cultured KW - Interleukin-4 -- pharmacology KW - Mice KW - Mice, Inbred BALB C KW - Drug Synergism KW - Female KW - Lymphocyte Activation -- drug effects KW - Tretinoin -- pharmacology KW - Interleukin-2 -- pharmacology KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73049347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Potentiation+of+IL-2-induced+t-cell+proliferation+by+retinoids.&rft.au=Jiang%2C+X+L%3BDillehay%2C+D+L%3BEverson%2C+M+P%3BTilden%2C+A+B%3BLamon%2C+E+W&rft.aulast=Jiang&rft.aufirst=X&rft.date=1992-02-01&rft.volume=14&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-13 N1 - Date created - 1992-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma-bearing mice. AN - 72921350; 1579055 AB - To test for a regulatory defect in adipose triacylglycerol (essential) fatty acid mobilization in lymphoma-bearing mice, free [1-14C]linoleic acid/mouse serum albumin was injected iv into lymphoma-bearing and control mice, adapted to a reversed light cycle, and studied in three dietary states in the dark period. Mean daily food intake decreased in mice with small and large tumor burdens. Plasma free fatty acid (FFA) oxidation rates, which approximate FFA mobilization rates, were estimated by multicompartmental analysis (CONSAM). Oxidation of linoleate to CO2 was reduced significantly (85%) in ad libitum fed as compared to briefly fasted control mice but not in fed vs. fasted mice with large or small tumor burdens. However, plasma FFA oxidation rates to CO2 did not differ in briefly fasted tumor-bearing and pair-fed control mice. When re-fed a 250-mg test meal, briefly fasted mice with small tumors suppressed plasma free linoleic acid oxidation, as did controls. During simulated night, mildly anorexic, tumor-bearing mice with small tumor burdens mobilized essential fatty acids much faster than controls. This could explain body fat loss. The abnormally rapid rates of FFA (free linoleic acid) mobilization at night probably result from anorexia rather than from inability of food to suppress fat mobilization. JF - Lipids AU - Kannan, R AU - Gan-Elepano, M AU - Baker, N AD - Liver Research Laboratory, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 117 EP - 123 VL - 27 IS - 2 SN - 0024-4201, 0024-4201 KW - Appetite Depressants KW - 0 KW - Fatty Acids KW - Linoleic Acids KW - Peptides KW - lipid mobilizing substance KW - Linoleic Acid KW - 9KJL21T0QJ KW - Index Medicus KW - Animals KW - Fasting -- adverse effects KW - Body Burden KW - Appetite Regulation -- physiology KW - Metabolic Clearance Rate KW - Disease Models, Animal KW - Neoplasms, Experimental -- metabolism KW - Mice KW - Peptides -- physiology KW - Male KW - Lipid Mobilization -- physiology KW - Linoleic Acids -- metabolism KW - Lymphoma -- metabolism KW - Fatty Acids -- metabolism KW - Anorexia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72921350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Anorexic+contribution+to+increased+linoleate+mobilization+and+oxidation+in+lymphoma-bearing+mice.&rft.au=Kannan%2C+R%3BGan-Elepano%2C+M%3BBaker%2C+N&rft.aulast=Kannan&rft.aufirst=R&rft.date=1992-02-01&rft.volume=27&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-11 N1 - Date created - 1992-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outcomes of co-morbid alcoholic men: a 1-year follow-up. AN - 72879175; 1313661 AB - In this prospective, 1-year study, 360 males admitted to an inpatient alcoholism treatment program were administered a DSM-III compatible structured interview and subtyped by co-occurring psychiatric disorder. Forty percent satisfied diagnostic criteria for alcohol dependence while 27% met criteria for alcohol dependence and one additional psychiatric syndrome. The dually diagnosed patients were divided into: alcohol dependence plus drug abuse, alcohol dependence plus antisocial personality and alcohol dependence plus depression. These subtypes were compared on multiple dimensions at intake and at 1-year follow-up. At follow-up, all groups showed significant improvement in drinking and psychosocial functioning. The results suggest that subtyping alcoholics by co-morbid psychiatric disorders may be a good postdictor of clinical history, but a poor predictor of drinking outcome. JF - Alcoholism, clinical and experimental research AU - Powell, B J AU - Penick, E C AU - Nickel, E J AU - Liskow, B I AU - Riesenmy, K D AU - Campion, S L AU - Brown, E F AD - Veterans Administration Medical Center, Kansas City, Missouri 64128-2295. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 131 EP - 138 VL - 16 IS - 1 SN - 0145-6008, 0145-6008 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Depressive Disorder -- psychology KW - Humans KW - Antisocial Personality Disorder -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Substance Abuse Treatment Centers KW - Adult KW - Antisocial Personality Disorder -- rehabilitation KW - Follow-Up Studies KW - Middle Aged KW - Male KW - Depressive Disorder -- rehabilitation KW - Alcoholism -- rehabilitation KW - Mental Disorders -- rehabilitation KW - Mental Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72879175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Outcomes+of+co-morbid+alcoholic+men%3A+a+1-year+follow-up.&rft.au=Powell%2C+B+J%3BPenick%2C+E+C%3BNickel%2C+E+J%3BLiskow%2C+B+I%3BRiesenmy%2C+K+D%3BCampion%2C+S+L%3BBrown%2C+E+F&rft.aulast=Powell&rft.aufirst=B&rft.date=1992-02-01&rft.volume=16&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of cAMP in mediating effects of fasting on dephosphorylation of insulin receptor. AN - 72821426; 1311506 AB - We studied the effect of fasting on phosphotyrosine phosphatase (PTPase) activities in particulate (PF) and cytosolic (CF) fractions of rat adipocytes and liver. PTPase activity was assessed using [32P]tyrosine insulin receptor (IR). In adipocytes, 48 h fasting significantly inhibited PTPase activity. Dephosphorylation of IR by PF and CF PTPases was reduced by 80 and 65%, respectively. Similar reductions of lesser magnitude were observed in fasted rat livers. The effect of fasting was completely reversed by either refeeding or by incubating "fasted" adipocytes for 2 h in tissue culture medium containing 5 mM glucose. Neither 20 mM glucose nor the presence of insulin influenced phosphatase activity. Because fasting is accompanied by elevated protein kinase C (PKC) and adenosine 3',5'-cyclic monophosphate (cAMP) levels, we examined their influence on adipocyte PTPases. Neither activation (1 microM 12-O-tetradecanoylphorbol-13-acetate) nor inhibition (20 microM sphingosine) of PKC affected PTPase activity. In contrast, cAMP (2 mM) significantly inhibited PTPase activity (80% inhibition at 2 h), and its effect was prevented by a cAMP antagonist RpcAMP. Fasting- and cAMP-induced inhibition of PTPase activity was restored by incubating PF with trypsin (4 micrograms/ml for 5 min), which separated the putative inhibitors from the phosphatases. We conclude that fasting-induced inhibition of PTPases is mediated by elevated cAMP levels, most likely by activating phosphatase inhibitors. JF - The American journal of physiology AU - Begum, N AU - Graham, A L AU - Sussman, K E AU - Draznin, B AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - E142 EP - E149 VL - 262 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Bucladesine KW - 63X7MBT2LQ KW - Cyclic AMP KW - E0399OZS9N KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Protein Tyrosine Phosphatases KW - EC 3.1.3.48 KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Protein Tyrosine Phosphatases -- metabolism KW - Phosphorylation KW - Glucose -- pharmacology KW - Adipose Tissue -- cytology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Bucladesine -- pharmacology KW - Adipose Tissue -- enzymology KW - Protein Tyrosine Phosphatases -- antagonists & inhibitors KW - Male KW - Fasting KW - Cyclic AMP -- physiology KW - Receptor, Insulin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72821426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+cAMP+in+mediating+effects+of+fasting+on+dephosphorylation+of+insulin+receptor.&rft.au=Begum%2C+N%3BGraham%2C+A+L%3BSussman%2C+K+E%3BDraznin%2C+B&rft.aulast=Begum&rft.aufirst=N&rft.date=1992-02-01&rft.volume=262&rft.issue=2+Pt+1&rft.spage=E142&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Case report: distinctive immune abnormalities in a patient with procainamide-induced lupus and serositis. AN - 72819835; 1371640 AB - To gain insight into the immunopathogenesis of drug-induced autoimmune disorders, lymphocyte and immunoglobulin distributions and cytokine levels were monitored in the peripheral blood and pleural fluid of a patient with procainamide-induced lupus and pleural effusion. Approximately 80% of the B cells in both compartments were CD5+ compared to 10% to 25% in normal adults. CD4/CD8 ratio and percentage CD4 were normal in peripheral blood. Serum levels of IgG (particularly IgG2), IL-6, and soluble IL-2R were slightly elevated, and those of IgA were significantly elevated compared to normal controls. Analysis of the pleural effusion revealed an increased CD4/CD8 ratio because of an increased percentage of CD4+CD29+ helper memory T cells, lack of expression of the resting B-cell marker CD21, immune complex deposition and complement consumption, increased relative levels of ANA, abnormally high levels of IL-6 and soluble IL-2R, and detectable levels of IL-1b, IFN-g and TNF-a. These observations provide evidence for the involvement of CD5+ B cells and differential helper T-cell activity in procainamide-induced lupus and for an association between local lymphocyte activation and organ pathology. JF - The American journal of the medical sciences AU - Klimas, N G AU - Patarca, R AU - Perez, G AU - Garcia-Morales, R AU - Schultz, D AU - Schabel, J AU - Fletcher, M A AD - Miami Veterans Administration Medical Center, Florida. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 99 EP - 104 VL - 303 IS - 2 SN - 0002-9629, 0002-9629 KW - Antigens, CD KW - 0 KW - Antigens, CD29 KW - Antigens, CD4 KW - Antigens, CD5 KW - Cytokines KW - Receptors, Interleukin-2 KW - Procainamide KW - L39WTC366D KW - Abridged Index Medicus KW - Index Medicus KW - Antigens, CD -- analysis KW - Antigens, CD4 -- analysis KW - Receptors, Interleukin-2 -- analysis KW - Humans KW - Autoimmune Diseases -- chemically induced KW - Aged KW - B-Lymphocytes -- immunology KW - Male KW - Autoimmune Diseases -- immunology KW - Cytokines -- analysis KW - Lymphocytes -- immunology KW - Lupus Vulgaris -- chemically induced KW - Procainamide -- adverse effects KW - Serositis -- chemically induced KW - Serositis -- immunology KW - Lupus Vulgaris -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72819835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Case+report%3A+distinctive+immune+abnormalities+in+a+patient+with+procainamide-induced+lupus+and+serositis.&rft.au=Klimas%2C+N+G%3BPatarca%2C+R%3BPerez%2C+G%3BGarcia-Morales%2C+R%3BSchultz%2C+D%3BSchabel%2C+J%3BFletcher%2C+M+A&rft.aulast=Klimas&rft.aufirst=N&rft.date=1992-02-01&rft.volume=303&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-27 N1 - Date created - 1992-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transesophageal echocardiographic diagnosis of acute aortic dissection complicating cocaine abuse. AN - 72806919; 1736595 JF - American heart journal AU - Om, A AU - Porter, T AU - Mohanty, P K AD - McGuire Veterans Administration Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 532 EP - 534 VL - 123 IS - 2 SN - 0002-8703, 0002-8703 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Aneurysm, Dissecting -- diagnostic imaging KW - Echocardiography -- methods KW - Aneurysm, Dissecting -- chemically induced KW - Aortic Aneurysm -- chemically induced KW - Substance Abuse, Intravenous -- complications KW - Aortic Aneurysm -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72806919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Transesophageal+echocardiographic+diagnosis+of+acute+aortic+dissection+complicating+cocaine+abuse.&rft.au=Om%2C+A%3BPorter%2C+T%3BMohanty%2C+P+K&rft.aulast=Om&rft.aufirst=A&rft.date=1992-02-01&rft.volume=123&rft.issue=2&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-06 N1 - Date created - 1992-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The late auditory evoked potential masking-level difference as a function of noise level. AN - 72801287; 1735971 AB - The purpose of this study was to determine whether the masking-level difference (MLD) obtained with the late (P2) auditory evoked potentials has characteristics similar to those reported for the behavioral MLD with respect to the effects of noise level. Psychoacoustic studies have shown that the magnitude of the MLD increases as a function of the noise level. In the present study, P2 thresholds were measured in SoNo (signals and noise in phase at the ears) and S pi No (signals out of phase and noise in phase at the ears) conditions for noise levels of 0-60 dB pressure spectrum level (Lps). Subjects were 5 normal-hearing young adults. The difference in SoNo and S pi No thresholds, or the MLD, increased linearly as the noise levels increased through 60 dB Lps, whereas the behavioral MLD magnitude is reported to saturate at high noise levels. These results suggest that the late-potential MLD reflects characteristics similar to, but not identical with, those of the behavioral MLD. JF - Journal of speech and hearing research AU - Fowler, C G AU - Mikami, C M AD - Veterans Administration Medical Center, Long Beach, CA. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 216 EP - 221 VL - 35 IS - 1 SN - 0022-4685, 0022-4685 KW - Index Medicus KW - Auditory Threshold KW - Humans KW - Adult KW - Male KW - Female KW - Noise KW - Evoked Potentials, Auditory KW - Perceptual Masking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72801287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech+and+hearing+research&rft.atitle=The+late+auditory+evoked+potential+masking-level+difference+as+a+function+of+noise+level.&rft.au=Fowler%2C+C+G%3BMikami%2C+C+M&rft.aulast=Fowler&rft.aufirst=C&rft.date=1992-02-01&rft.volume=35&rft.issue=1&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech+and+hearing+research&rft.issn=00224685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aspiration injury due to polyacrylamide. AN - 72800773; 1735299 AB - Acute lung injury secondary to aspiration of polyacrylamide, a synthetic polymer used widely in industry, has not been previously described in man or animal. We report the case of a 26-year-old man who aspirated polyacrylamide gel while cleaning it out of a tank truck. Subsequently, severe airway obstruction and lung parenchymal damage developed, and the patient died. At autopsy, numerous polyacrylamide particles were found in the lungs, along with extensive bronchiolar and alveolar damage. JF - Chest AU - Jubran, A AU - Greenberg, S D AU - Solomon, M D AU - Noall, M W AU - Tobin, M J AD - Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr, Veterans Administration Hospital, Loyola University of Chicago Stritch School of Medicine, Maywood, Ill. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 576 EP - 578 VL - 101 IS - 2 SN - 0012-3692, 0012-3692 KW - Acrylic Resins KW - 0 KW - Gels KW - polyacrylamide KW - 9003-05-8 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Lung -- pathology KW - Bronchi -- pathology KW - Male KW - Inhalation KW - Airway Obstruction -- etiology KW - Airway Obstruction -- pathology KW - Accidents, Occupational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72800773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Aspiration+injury+due+to+polyacrylamide.&rft.au=Jubran%2C+A%3BGreenberg%2C+S+D%3BSolomon%2C+M+D%3BNoall%2C+M+W%3BTobin%2C+M+J&rft.aulast=Jubran&rft.aufirst=A&rft.date=1992-02-01&rft.volume=101&rft.issue=2&rft.spage=576&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-12 N1 - Date created - 1992-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Structural basis for the barrier abnormality following inhibition of HMG CoA reductase in murine epidermis. AN - 72789166; 1732385 AB - Recent studies have shown that increased epidermal 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase activity is crucial for the barrier recovery response that follows solvent-induced barrier perturbation. Upregulation of this enzyme leads to increased cholesterologenesis, formation and secretion of cholesterol-enriched lamellar bodies, and barrier repair. Topical lovastatin-induced inhibition of HMG CoA reductase activity both delays the acute barrier-repair response, as well as leading to a chronic barrier abnormality when applied repeatedly to intact skin. Presently, we assessed the effects of repeated topical applications of two different specific inhibitors of HMG CoA reductase on barrier function, the lamellar body-secretory system, and stratum corneum intercellular domains, with functional and morphologic parameters. Once-daily applications of lovastatin or fluindostatin (XU62-320; Sandoz) for 4-8 d to intact hairless mouse epidermis produced a progressive abnormality in barrier function (transepidermal water loss greater than 2.0-5.0 in treated versus less than 0.25 mg/cm2/h for weakly active analogues or vehicle controls). The barrier defect was preceded by alterations in lamellar body internal structure and a partial failure of lamellar body secretion into the stratum corneum interstices, further confirmed by enzyme cytochemistry. Moreover, the deposition of abnormal lamellar body contents resulted in the formation of clefts in the intercellular spaces at the stratum granulosum-stratum corneum interface, resulting in increased permeability through these domains shown by lanthanum perfusion. Applications of irritants, even when producing a barrier abnormality, did not alter the lamellar body secretory system. Co-applications of cholesterol with the inhibitors reversed both the barrier abnormality and the abnormalities in the lamellar body secretory system that occur with the inhibitor alone. Finally, membrane bilayer structures in the mid-to-outer stratum corneum of inhibitor-treated specimens appeared normal, but the intercellular domains displayed enormously expanded lacunae. However, because similar dilatations also occurred in vehicle-treated samples, they can be attributed to the vehicle alone. These studies provide further evidence that the inhibitor-induced defect in barrier function a) is initiated by inhibition of HMG CoA reductase; b) can be attributed to defects in both lamellar body structure and deposition with resultant abnormalities in intercellular membrane domains in the lower stratum corneum; and c) is further enhanced by permissive effects of the vehicle on the permeability of the outer stratum corneum. JF - The Journal of investigative dermatology AU - Menon, G K AU - Feingold, K R AU - Mao-Qiang, M AU - Schaude, M AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 209 EP - 219 VL - 98 IS - 2 SN - 0022-202X, 0022-202X KW - Alkanes KW - 0 KW - Fatty Acids, Monounsaturated KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Indoles KW - fluvastatin KW - 4L066368AS KW - Lanthanum KW - 6I3K30563S KW - Cholesterol KW - 97C5T2UQ7J KW - Lovastatin KW - 9LHU78OQFD KW - Lipase KW - EC 3.1.1.3 KW - n-hexadecane KW - F8Z00SHP6Q KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Fatty Acids, Monounsaturated -- pharmacology KW - Lipase -- analysis KW - Mice KW - Lovastatin -- pharmacology KW - Mice, Hairless KW - Histocytochemistry KW - Alkanes -- pharmacology KW - Cholesterol -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Indoles -- pharmacology KW - Up-Regulation KW - Dermatitis -- metabolism KW - Epidermis -- ultrastructure KW - Male KW - Skin -- drug effects KW - Cell Membrane Permeability -- drug effects KW - Skin -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Structural+basis+for+the+barrier+abnormality+following+inhibition+of+HMG+CoA+reductase+in+murine+epidermis.&rft.au=Menon%2C+G+K%3BFeingold%2C+K+R%3BMao-Qiang%2C+M%3BSchaude%2C+M%3BElias%2C+P+M&rft.aulast=Menon&rft.aufirst=G&rft.date=1992-02-01&rft.volume=98&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A randomized phase II trial of continuous infusion interleukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma. AN - 72785785; 1732429 AB - Since 1985, multiple centers have demonstrated that interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells produce durable anticancer responses in patients with metastatic renal cell carcinoma. High-dose recombinant IL-2 (rIL-2) has been administered by intravenous bolus injection (Rosenberg SA, et al: N Engl J Med 313:1485-1492, 1985) and by continuous intravenous infusion (West WH, et al: N Engl J Med 316:898-905, 1987) combined with lymphokine-activated killer (LAK) cells, with both methods producing responses in patients with advanced renal cell carcinoma. The Extramural IL-2/LAK Working Group has conducted a randomized phase II trial of two intravenous high-dose rIL-2 regimens (bolus three times daily or 24-hour continuous infusion) to determine if either one manifests greater anticancer activity or a more acceptable toxicity profile. Ninety-four patients with measurable advanced renal cell carcinoma were enrolled on this study: 46 to the bolus injection arm and 48 to the continuous infusion arm. On both arms, patients underwent a priming phase of rIL-2 administration, four daily lymphocytaphereses to harvest mononuclear cells that were placed in 3- to 4-day culture for generation of LAK cells, and an rIL-2/LAK coadministration phase. Patients were then observed monthly for evidence of response to this therapy and were offered up to two additional courses of treatment every 3 months if evidence of response was detected. Twenty percent of patients on the bolus injection arm experienced objective responses (three complete responses and six partial responses); 15% of patients on the continuous infusion arm responded (two complete responses and five partial responses). Complete responses were durable, persisting for 310+ to 700+ days. The incidence of severe life-threatening toxicities typical of high-dose rIL-2 therapy was similar in both arms (eg, patients with hypotension requiring pressors: bolus 71%, continuous 63%; oliguria less than or equal to 200 mL/8 hours: bolus 65%, continuous 71%). More episodes of fever, infection, and serum alkaline phosphatase elevation were associated with the continuous infusion arm, while more thrombocytopenia occurred on the bolus injection arm. Four patients (three bolus injection, one continuous infusion) died of respiratory and circulatory failure while under treatment. No clinical or laboratory parameter accompanying treatment on either arm was, by univariate or multivariate analysis, associated with an increased likelihood of response. Both methods of high-dose rIL-2/LAK cell administration produce nearly equivalent anticancer activity and toxicity in the treatment of renal cell carcinoma. The ability to predict responding patients based on patient or treatment characteristics is not possible. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Weiss, G R AU - Margolin, K A AU - Aronson, F R AU - Sznol, M AU - Atkins, M B AU - Dutcher, J P AU - Gaynor, E R AU - Boldt, D H AU - Doroshow, J H AU - Bar, M H AD - Extramural IL-2/LAK Working Group, University of Texas Health Science Center/Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio 8284. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 275 EP - 281 VL - 10 IS - 2 SN - 0732-183X, 0732-183X KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Index Medicus KW - Infusions, Intravenous KW - Injections, Intravenous KW - Combined Modality Therapy KW - Humans KW - Aged KW - Drug Evaluation KW - Adult KW - Middle Aged KW - Adolescent KW - Recombinant Proteins -- therapeutic use KW - Female KW - Male KW - Recombinant Proteins -- administration & dosage KW - Kidney Neoplasms -- therapy KW - Interleukin-2 -- administration & dosage KW - Carcinoma, Renal Cell -- therapy KW - Interleukin-2 -- therapeutic use KW - Killer Cells, Lymphokine-Activated -- transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72785785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=A+randomized+phase+II+trial+of+continuous+infusion+interleukin-2+or+bolus+injection+interleukin-2+plus+lymphokine-activated+killer+cells+for+advanced+renal+cell+carcinoma.&rft.au=Weiss%2C+G+R%3BMargolin%2C+K+A%3BAronson%2C+F+R%3BSznol%2C+M%3BAtkins%2C+M+B%3BDutcher%2C+J+P%3BGaynor%2C+E+R%3BBoldt%2C+D+H%3BDoroshow%2C+J+H%3BBar%2C+M+H&rft.aulast=Weiss&rft.aufirst=G&rft.date=1992-02-01&rft.volume=10&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of expression of the leukocyte integrin CD11a (LFA-1) molecule during differentiation of HL-60 cells along the monocyte/macrophage pathway. AN - 72777946; 1730867 AB - The CD11a/CD18 (LFA-1) leukocyte integrin receptor mediates homotypic and heterotypic leukocyte adhesion by binding to one of two defined ligands, ICAM-1 or 2, on the conjugate cell. In this study we investigated the molecular regulation of expression of the CD11a subunit during myeloid differentiation of HL-60 cells. Induction of monocyte/macrophage differentiation of HL-60 promyelocytic leukemia cells with PMA results in an increase in CD11a surface Ag expression and the acquisition of CD11a/CD18-mediated homotypic adherence. These changes are accompanied by a 40-fold increase in CD11a mRNA levels. Nuclear run-on transcription assays indicate that the increase in CD11a mRNA in PMA-induced HL-60 cells is not caused by an increase in CD11a RNA transcription. We assessed the posttranscriptional regulation of CD11a using two methods. By using actinomycin D to block RNA transcription, we demonstrate that the CD11a mRNA half-life in HL-60 cells is prolonged after PMA treatment. Inhibition of protein synthesis with cycloheximide also results in enhanced expression of CD11a mRNA in HL-60 cells without increasing CD11a transcription. These findings indicate that, in HL-60 cells induced with PMA to differentiate along the monocyte/macrophage pathway, CD11a expression is regulated primarily at the posttranscriptional level by a labile protein. Identification of the specific CD11a RNA sequences, and the proteins that bind to these sequences may provide insight into lineage commitment during human monocyte/macrophage differentiation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Back, A L AU - Gollahon, K A AU - Hickstein, D D AD - Medical Research Division, Seattle Veterans Administration Medical Center, WA 98108. Y1 - 1992/02/01/ PY - 1992 DA - 1992 Feb 01 SP - 710 EP - 714 VL - 148 IS - 3 SN - 0022-1767, 0022-1767 KW - Lymphocyte Function-Associated Antigen-1 KW - 0 KW - RNA, Messenger KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Blotting, Northern KW - Tumor Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Gene Expression KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Transcription, Genetic KW - Leukemia, Myeloid -- pathology KW - Cell Membrane -- metabolism KW - RNA, Messenger -- genetics KW - Cell Differentiation -- drug effects KW - Lymphocyte Function-Associated Antigen-1 -- genetics KW - Monocytes -- physiology KW - Macrophages -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72777946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Regulation+of+expression+of+the+leukocyte+integrin+CD11a+%28LFA-1%29+molecule+during+differentiation+of+HL-60+cells+along+the+monocyte%2Fmacrophage+pathway.&rft.au=Back%2C+A+L%3BGollahon%2C+K+A%3BHickstein%2C+D+D&rft.aulast=Back&rft.aufirst=A&rft.date=1992-02-01&rft.volume=148&rft.issue=3&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-19 N1 - Date created - 1992-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of Semantic Context and Expectancy in a Lexical Decision and Naming Task AN - 85548567; 9207613 AB - A single-word priming study was used to investigate differences in the sensitivity of the lexical decision & naming tasks to postlexical processes. Relatedness probability was manipulated with an "induction set" presented to Ss (N = 48, aged 26-61) prior to stimuli onset. In the naming task, an induction set with a high probability of related word pairs produced both facilitation & inhibition; a high probability of unrelated word pairs resulted in similar response times to all word targets. Significant facilitation was found for the lexical decision task, regardless of the induction set relatedness. Data suggest that under some circumstances the naming task is sensitive to postrecognition contextual effects. They do not support the use of the lexical decision & naming tasks as methodological tools for a priori distinguishing pre- & postcontextual effects in word recognition. 3 Tables, 10 References. Adapted from the source document JF - The Bulletin of the Psychonomic Society AU - McGlinchey-Berroth, Regina AU - Milberg, William P AD - Geriatric Research Education & Clinical Center Brocton/West Roxbury Veterans Administration Medical Center, 1400 VFW Parkway West Roxbury MA 02132 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 421 EP - 424 VL - 30 IS - 5 SN - 0090-5054, 0090-5054 KW - lexical decision/naming tasks, postlexical processes influences differences KW - empirical data KW - adults aged 26-61 KW - Verbal Tasks (93800) KW - Context (15250) KW - Semantic Processing (76760) KW - Word Recognition (98200) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85548567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Bulletin+of+the+Psychonomic+Society&rft.atitle=Effects+of+Semantic+Context+and+Expectancy+in+a+Lexical+Decision+and+Naming+Task&rft.au=McGlinchey-Berroth%2C+Regina%3BMilberg%2C+William+P&rft.aulast=McGlinchey-Berroth&rft.aufirst=Regina&rft.date=1992-01-01&rft.volume=30&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=The+Bulletin+of+the+Psychonomic+Society&rft.issn=00905054&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BPNSBY N1 - SubjectsTermNotLitGenreText - Word Recognition (98200); Semantic Processing (76760); Verbal Tasks (93800); Context (15250) ER - TY - JOUR T1 - Two doses of omeprazole versus placebo in symptomatic erosive esophagitis: the U.S. Multicenter Study. AN - 85243412; pmid-1727744 AB - Two hundred thirty patients with reflux symptoms and endoscopically proven erosive esophagitis were enrolled from 15 U.S. centers into a randomized, double-blind, dose-ranging study comparing placebo with omeprazole, 20 or 40 mg given once daily in the morning. Esophagitis grade 2 was present in 44% of patients, grade 3 in 37% of patients, and grade 4 in 19% of patients. Endpoints, defined as complete relief of heartburn and complete esophageal mucosal healing, were assessed after 4 and 8 weeks of treatment. Both omeprazole doses were significantly superior to placebo in complete endoscopic healing. After 8 weeks of treatment, 73.5% of patients in the 20-mg omeprazole group and 74.7% in the 40-mg omeprazole group, compared with 14.0% in the placebo group, had complete healing of the esophageal mucosa. At the end of the study, complete relief of daytime heartburn was obtained in 79.5% of patients in the 20-mg omeprazole group, 81.6% in the 40-mg omeprazole group, and 37.2% in the placebo group (P less than or equal to 0.05). Complete relief of nighttime heartburn was noted by 79.5% of patients in the 20-mg omeprazole group, 85.1% in the 40-mg omeprazole group, and 34.9% in the placebo group (P less than or equal to 0.05). The median time to complete relief of daytime and nighttime heartburn occurred earlier in the 40-mg group than in the 20-mg group (9 vs. 17 days and 9 vs. 20 days, respectively); however, these differences were not statistically significant. Relief of acid regurgitation and dysphagia also occurred earlier in the 40-mg group. Omeprazole was well tolerated in this group of patients. No unexpected adverse experiences occurred. The results of this study confirm those of six multicenter, international trials in which omeprazole in doses of 20-60 mg provided a degree of esophageal mucosal healing and complete relief of reflux symptoms superior to any other medical treatment. JF - Gastroenterology AU - Sontag, S J AU - Hirschowitz, B I AU - Holt, S AU - Robinson, M G AU - Behar, J AU - Berenson, M M AU - McCullough, A AU - Ippoliti, A F AU - Richter, J E AU - Ahtaridis, G AD - Veterans Administration Hospital, Hines, Illinois. PY - 1992 SP - 109 EP - 118 VL - 102 IS - 1 SN - 0016-5085, 0016-5085 KW - Dose-Response Relationship, Drug KW - Human KW - Aged KW - Omeprazole KW - Esophagoscopy KW - Esophagitis KW - Stomach Diseases KW - Aged, 80 and over KW - Adult KW - Middle Age KW - Support, Non-U.S. Gov't KW - Placebos KW - Antacids KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85243412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Two+doses+of+omeprazole+versus+placebo+in+symptomatic+erosive+esophagitis%3A+the+U.S.+Multicenter+Study.&rft.au=Sontag%2C+S+J%3BHirschowitz%2C+B+I%3BHolt%2C+S%3BRobinson%2C+M+G%3BBehar%2C+J%3BBerenson%2C+M+M%3BMcCullough%2C+A%3BIppoliti%2C+A+F%3BRichter%2C+J+E%3BAhtaridis%2C+G&rft.aulast=Sontag&rft.aufirst=S&rft.date=1992-01-01&rft.volume=102&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Periventricular white matter changes and oropharyngeal swallowing in normal individuals. AN - 85154881; pmid-1499355 AB - Cranial magnetic resonance imaging (MRI) has revealed patchy periventricular white matter lesions or "unidentified bright objects" (UBOs) in otherwise neurologically intact individuals. Quantitative videofluoroscopic swallowing evaluations and cranial MRI examinations were studied in 49 neurologically normal volunteers (ages 43 to 79 years). Total swallowing duration (TSD) and its subcomponents of oral transit duration (OTD), stage transition duration (STD), and pharyngeal response duration were measured for liquid and semisolid swallows. MRIs were graded from 0, or no UBOs, to 3, or multiple and confluent lesions. The effect of the presence of UBOs on swallowing durational measures and risk factors was analyzed with age differences accounted for statistically (ANCOVA). TSD and OTD for semisolids were significantly differentiated by MRI score (P less than 0.009 and P less than 0.047, respectively). That is, a demonstrable effect was found for an increased number of UBOs on duration of oropharyngeal swallowing in normal individuals. JF - Dysphagia AU - Levine, R AU - Robbins, J A AU - Maser, A AD - Department of Neurology, William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin 53705. PY - 1992 SP - 142 EP - 147 VL - 7 IS - 3 SN - 0179-051X, 0179-051X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85154881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Periventricular+white+matter+changes+and+oropharyngeal+swallowing+in+normal+individuals.&rft.au=Levine%2C+R%3BRobbins%2C+J+A%3BMaser%2C+A&rft.aulast=Levine&rft.aufirst=R&rft.date=1992-01-01&rft.volume=7&rft.issue=3&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tolerance, withdrawal, and supersensitivity to dopamine mediated cues in a drug-drug discrimination. AN - 75541675; 1365673 AB - Rats were trained to discriminate between 0.25 mg/kg amphetamine (AMPH) and 0.03 mg/kg haloperidol (HAL) in a two-lever drug discrimination task. In order to test for a drug-induced withdrawal state, animals were assigned to one of three chronic treatment groups and given injections of AMPH, HAL, or distilled water (DW) for 10 consecutive days. Subjects from each treatment condition were then tested at 24, 48, or 72 h after the final injection. At the 24 h retest interval, subjects injected with AMPH responded as though administered an acute dose of HAL (0.028 mg/kg) and subjects injected with chronic HAL responded as though administered an acute dose of AMPH (0.15 mg/kg). By 72 h choice behavior had returned to pretreatment values. To determine whether the rebound observed after 10 days of drug treatment was present after a single injection, independent groups of subjects were injected with single doses of either 10 mg/kg AMPH or 1.0 mg/kg HAL and then retested from 4 h to 48 h later. Single doses of both AMPH and HAL produced significant rebounds that peaked between 20 h (AMPH) and 24 h (HAL) following administration. In a third experiment, animals were tested with or without acute doses of drug following pretreatment with either HAL or AMPH. Receptor supersensitivity accounts for the tolerance observed to HAL 24 h after treatment with 1.0 mg/kg HAL, whereas receptor subsensitivity accounts for the tolerance observed 20 h after treatment with 10 mg/kg AMPH. JF - Psychopharmacology AU - Barrett, R J AU - White, D K AU - Caul, W F AD - Veterans Administration Medical Center, Department of Psychology, Vanderbilt University, Nashville, TN. Y1 - 1992 PY - 1992 DA - 1992 SP - 63 EP - 67 VL - 109 IS - 1-2 SN - 0033-3158, 0033-3158 KW - Haloperidol KW - J6292F8L3D KW - Dextroamphetamine KW - TZ47U051FI KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Drug Tolerance KW - Animals KW - Rats, Sprague-Dawley KW - Haloperidol -- pharmacology KW - Male KW - Dextroamphetamine -- pharmacology KW - Discrimination (Psychology) -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Discrimination (Psychology) -- physiology KW - Dopamine -- physiology KW - Cues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75541675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Tolerance%2C+withdrawal%2C+and+supersensitivity+to+dopamine+mediated+cues+in+a+drug-drug+discrimination.&rft.au=Barrett%2C+R+J%3BWhite%2C+D+K%3BCaul%2C+W+F&rft.aulast=Barrett&rft.aufirst=R&rft.date=1992-01-01&rft.volume=109&rft.issue=1-2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-23 N1 - Date created - 1995-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic encephalopathy: a disorder in glial-neuronal communication. AN - 73533611; 1283790 JF - Progress in brain research AU - Norenberg, M D AU - Neary, J T AU - Bender, A S AU - Dombro, R S AD - Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL. Y1 - 1992 PY - 1992 DA - 1992 SP - 261 EP - 269 VL - 94 SN - 0079-6123, 0079-6123 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Ion Channels KW - Receptors, GABA-A KW - Ammonia KW - 7664-41-7 KW - Glycogen KW - 9005-79-2 KW - Cyclic AMP KW - E0399OZS9N KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Receptors, GABA-A -- physiology KW - Humans KW - Glial Fibrillary Acidic Protein -- metabolism KW - Cell Size -- drug effects KW - Cytoskeleton -- drug effects KW - Ion Channels -- metabolism KW - Glycogen -- metabolism KW - Cells, Cultured KW - Signal Transduction -- drug effects KW - Calcium -- physiology KW - Cyclic AMP -- metabolism KW - Receptors, GABA-A -- drug effects KW - Cytoskeleton -- ultrastructure KW - Brain Edema -- pathology KW - Astrocytes -- drug effects KW - Ammonia -- toxicity KW - Hepatic Encephalopathy -- pathology KW - Astrocytes -- pathology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73533611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+brain+research&rft.atitle=Hepatic+encephalopathy%3A+a+disorder+in+glial-neuronal+communication.&rft.au=Norenberg%2C+M+D%3BNeary%2C+J+T%3BBender%2C+A+S%3BDombro%2C+R+S&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1992-01-01&rft.volume=94&rft.issue=&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Progress+in+brain+research&rft.issn=00796123&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-17 N1 - Date created - 1993-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dental office recordkeeping requirements under the MOSH/OSHA bloodborne pathogens standard. AN - 73500774; 1289458 JF - Journal of the Maryland State Dental Association AU - Goodman, H S AU - Ward, M A AU - DePaola, L G AD - Veterans Administration Medical Center, Perry Point, MD. Y1 - 1992 PY - 1992 DA - 1992 SP - 17 EP - 19 VL - 35 IS - 1 SN - 0025-4355, 0025-4355 KW - Dentistry KW - United States KW - Maryland KW - United States Occupational Safety and Health Administration -- legislation & jurisprudence KW - Practice Management, Dental -- legislation & jurisprudence KW - Dentists KW - Dental Records KW - Occupational Exposure -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73500774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Maryland+State+Dental+Association&rft.atitle=Dental+office+recordkeeping+requirements+under+the+MOSH%2FOSHA+bloodborne+pathogens+standard.&rft.au=Goodman%2C+H+S%3BWard%2C+M+A%3BDePaola%2C+L+G&rft.aulast=Goodman&rft.aufirst=H&rft.date=1992-01-01&rft.volume=35&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Maryland+State+Dental+Association&rft.issn=00254355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-22 N1 - Date created - 1993-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cocaine and speedball users: differences in psychopathology. AN - 73435064; 1479627 AB - Affective distress and related symptoms associated with co-injected cocaine and opioid ("speedball") use are incompletely explored, and the extent to which they diverge from problems shown by cocaine abusers who do not prefer opioids is unknown. This investigation compared groups of speedball and non-speedball cocaine users on global measures of depression and anxiety and modal groupings of personality characteristics measured by the MMPI. Compared to men who use cocaine without opioids, compulsive speedball users evidenced significantly greater problems with depression, trait anxiety, and related symptomatology, and were more uniformly characterized by modal profiles reflecting severe psychopathology and maladjustment. These results agree with descriptions of severe pathology associated with speedball use. JF - Journal of substance abuse treatment AU - Malow, R M AU - West, J A AU - Corrigan, S A AU - Pena, J M AU - Lott, W C AD - Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1992 PY - 1992 DA - 1992 SP - 287 EP - 291 VL - 9 IS - 4 SN - 0740-5472, 0740-5472 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Anxiety -- psychology KW - Depression -- rehabilitation KW - Combined Modality Therapy KW - Anxiety -- rehabilitation KW - Humans KW - Depression -- psychology KW - Adult KW - Antisocial Personality Disorder -- rehabilitation KW - Antisocial Personality Disorder -- psychology KW - Male KW - Euphoria -- drug effects KW - MMPI KW - Heroin Dependence -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Heroin Dependence -- psychology KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73435064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Cocaine+and+speedball+users%3A+differences+in+psychopathology.&rft.au=Malow%2C+R+M%3BWest%2C+J+A%3BCorrigan%2C+S+A%3BPena%2C+J+M%3BLott%2C+W+C&rft.aulast=Malow&rft.aufirst=R&rft.date=1992-01-01&rft.volume=9&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationships between various uses of antineoplastic drug-interaction terms. AN - 73411467; 1333367 AB - In in vitro testing, no pharmacologic synergism has been found for the combination of cisplatin and etoposide in P388 leukemia in contrast to the demonstration of therapeutic synergism in the same model. No pharmacologic synergism has been found for the same combination in the treatment of four small-cell lung-cancer cell lines, although clinical results obtained using this combination in small-cell lung cancer and other cancers suggest a therapeutic advantage. The popular concept of synergy, implying a therapeutic advantage, is different from the pharmacologic meaning, which generally implies that less drug is required in a combination for an equal effect. Therapeutic advantage may be obtained regardless of whether drugs are synergistic in the pharmacologic sense in the treatment of a tumor. To gain a more comprehensive insight into concepts of drug interaction, it is important to recognize that the type of drug interaction seen is dependent on the drug doses used and may vary with the treatment of different cell lines. All of these factors complicate the use of the word synergism, or any associated term, in a categorical manner to describe the effects of combinations of antineoplastic drugs. JF - Cancer chemotherapy and pharmacology AU - Wampler, G L AU - Carter, W H AU - Campbell, E D AU - Keefe, P A AD - Department of Medicine, Richmond Veterans Administration Medical Center, Virginia 23249. Y1 - 1992 PY - 1992 DA - 1992 SP - 111 EP - 117 VL - 31 IS - 2 SN - 0344-5704, 0344-5704 KW - Antineoplastic Agents KW - 0 KW - Etoposide KW - 6PLQ3CP4P3 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Etoposide -- pharmacology KW - Animals KW - Tumor Cells, Cultured KW - Leukemia P388 -- drug therapy KW - Humans KW - Lung Neoplasms -- drug therapy KW - Cisplatin -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Terminology as Topic KW - Drug Synergism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73411467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Relationships+between+various+uses+of+antineoplastic+drug-interaction+terms.&rft.au=Wampler%2C+G+L%3BCarter%2C+W+H%3BCampbell%2C+E+D%3BKeefe%2C+P+A&rft.aulast=Wampler&rft.aufirst=G&rft.date=1992-01-01&rft.volume=31&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-31 N1 - Date created - 1992-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of aluminum on Na-K-ATPase activity in vitro. AN - 73402591; 1333938 JF - Contributions to nephrology AU - Adler, A J AU - Caruso, C AU - Berlyne, G M AD - Department of Medicine (111), Brooklyn Veterans Administration Hospital, N.Y. Y1 - 1992 PY - 1992 DA - 1992 SP - 118 EP - 126 VL - 100 SN - 0302-5144, 0302-5144 KW - Phosphates KW - 0 KW - Ouabain KW - 5ACL011P69 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Aluminum KW - CPD4NFA903 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Rats KW - Phosphates -- metabolism KW - Brain -- enzymology KW - Animals KW - Hydrogen-Ion Concentration KW - In Vitro Techniques KW - Kidney -- enzymology KW - Dogs KW - Ouabain -- pharmacology KW - Adenosine Triphosphate -- pharmacology KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Aluminum -- metabolism KW - Aluminum -- toxicity KW - Aluminum -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73402591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=The+effect+of+aluminum+on+Na-K-ATPase+activity+in+vitro.&rft.au=Adler%2C+A+J%3BCaruso%2C+C%3BBerlyne%2C+G+M&rft.aulast=Adler&rft.aufirst=A&rft.date=1992-01-01&rft.volume=100&rft.issue=&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-08 N1 - Date created - 1993-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mr R: a case study of withdrawal. AN - 73256384; 1330103 AB - This case study describes a patient with a long-time history of polysubstance abuse and dependence who was admitted to the hospital for detoxification from, and treatment for, his addictions. Despite physiological dependence upon the long-acting narcotic methadone, the patient did not show evidence of withdrawal from this agent until weeks after it was discontinued. This case emphasizes the psychological component of narcotic withdrawal. JF - Behavioral medicine (Washington, D.C.) AU - Dennison, S J AD - Chemical Dependency Treatment Section, Roudebush Veterans Administration Hospital, Indianapolis. Y1 - 1992 PY - 1992 DA - 1992 SP - 139 EP - 140 VL - 18 IS - 3 SN - 0896-4289, 0896-4289 KW - Cocaine KW - I5Y540LHVR KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Placebo Effect KW - Substance Abuse Treatment Centers KW - Humans KW - Neurologic Examination -- drug effects KW - Middle Aged KW - Clonidine -- therapeutic use KW - Male KW - Alcoholism -- rehabilitation KW - Methadone -- adverse effects KW - Methadone -- therapeutic use KW - Substance Withdrawal Syndrome -- diagnosis KW - Opioid-Related Disorders -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73256384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.atitle=Mr+R%3A+a+case+study+of+withdrawal.&rft.au=Dennison%2C+S+J&rft.aulast=Dennison&rft.aufirst=S&rft.date=1992-01-01&rft.volume=18&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.issn=08964289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-08 N1 - Date created - 1992-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of protein kinase C in constrictor responses of the rat basilar artery in vivo. AN - 73121523; 1501132 AB - 1. The goal of this study was to determine the effects of activation and inhibition of protein kinase C on the rat basilar artery in vivo. 2. The diameter of the basilar artery was measured through a craniotomy in rats anaesthetized with pentobarbitone sodium (50 mg kg-1, I.P., supplemented with 20 mg kg-1 h-1). Diameters were measured under control conditions and during topical application of various agonists, both alone and in the presence of antagonists. 3. Serotonin (5-HT) produced concentration-related constriction of the basilar artery (baseline diameter = 234 +/- 9 microns, mean +/- S.E.M.), which was inhibited by the 5-HT2 receptor antagonist LY53857. 4. Sphingosine (10(-6) M), a protein kinase C inhibitor which binds to the regulatory site of protein kinase C, inhibited the response to 10(-8) M-serotonin (-19 +/- 2% before vs. -3 +/- 2% during sphingosine, P less than 0.05). In contrast, constrictor responses to prostaglandin F2 alpha to (PGF2 alpha; 10(-6) M) were not inhibited by sphingosine (-16 +/- 2% before vs. -18 +/- 2% during sphingosine, P greater than 0.05). 5. H-7 (10(-9) M), another protein kinase C inhibitor, which binds to the catalytic site of protein kinase C, also inhibited constriction of the basilar artery in response to serotonin, but not prostaglandin F2 alpha. 6. Phorbol 12,13-dibutyrate (PDBu, 10(-8) M), which activates protein kinase C, produced slowly developing constriction of the basilar artery. PDBu-induced vasoconstriction (-33 +/- 2%) was attenuated by sphingosine (-11 +/- 4% during sphingosine, P less than 0.05) and H-7 (-1.5 +/- 5% during H-7, P less than 0.05). 7. In summary, activation of protein kinase C appears to mediate vasoconstrictor responses of the basilar artery to serotonin, but not PGF2 alpha. JF - The Journal of physiology AU - Murray, M A AU - Faraci, F M AU - Heistad, D D AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 169 EP - 179 VL - 445 SN - 0022-3751, 0022-3751 KW - Ergolines KW - 0 KW - Isoquinolines KW - Piperazines KW - Serotonin Antagonists KW - Serotonin KW - 333DO1RDJY KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - LY 53857 KW - 60634-51-7 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Dinoprost KW - B7IN85G1HY KW - Protein Kinase C KW - EC 2.7.11.13 KW - Sphingosine KW - NGZ37HRE42 KW - Index Medicus KW - Serotonin -- pharmacology KW - Animals KW - Serotonin Antagonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Ergolines -- pharmacology KW - Dinoprost -- pharmacology KW - Enzyme Activation -- physiology KW - Basilar Artery -- drug effects KW - Piperazines -- pharmacology KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Isoquinolines -- pharmacology KW - Basilar Artery -- physiology KW - Sphingosine -- pharmacology KW - Basilar Artery -- anatomy & histology KW - Male KW - Vasoconstriction -- physiology KW - Vasoconstriction -- drug effects KW - Protein Kinase C -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73121523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+physiology&rft.atitle=Role+of+protein+kinase+C+in+constrictor+responses+of+the+rat+basilar+artery+in+vivo.&rft.au=Murray%2C+M+A%3BFaraci%2C+F+M%3BHeistad%2C+D+D&rft.aulast=Murray&rft.aufirst=M&rft.date=1992-01-01&rft.volume=445&rft.issue=&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+physiology&rft.issn=00223751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-17 N1 - Date created - 1992-09-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1986 Jun 6;45(5):631-2 [3708690] J Physiol. 1987 Jun;387:115-23 [3116212] Nature. 1984 Apr 19-25;308(5961):693-8 [6232463] Biochem Biophys Res Commun. 1984 Apr 30;120(2):481-5 [6610416] J Biol Chem. 1982 Jul 10;257(13):7847-51 [7085651] J Cereb Blood Flow Metab. 1991 Jan;11(1):143-9 [1983998] Br J Pharmacol. 1991 Feb;102(2):415-21 [2015423] Am J Physiol. 1990 Nov;259(5 Pt 2):H1586-94 [2240255] Life Sci. 1987 Aug 31;41(9):1051-64 [2441225] Annu Rev Pharmacol Toxicol. 1989;29:71-110 [2543275] Am J Physiol. 1989 Sep;257(3 Pt 2):H799-803 [2675632] J Biol Chem. 1988 Oct 25;263(30):15241-4 [2844804] J Pharmacol Exp Ther. 1986 Aug;238(2):480-5 [3016238] Eur J Pharmacol. 1987 Apr 29;136(3):325-32 [3038568] J Biol Chem. 1987 Oct 5;262(28):13620-6 [3115982] J Physiol. 1987 Nov;392:333-48 [3446783] J Biol Chem. 1986 Sep 25;261(27):12604-9 [3462188] J Pharmacol Exp Ther. 1985 Nov;235(2):319-23 [4057073] Biochem J. 1984 Jun 1;220(2):345-60 [6146314] Biochemistry. 1984 Oct 9;23(21):5036-41 [6238627] Neuropharmacology. 1984 Oct;23(10):1223-5 [6521858] Brain Res. 1983 Jan 24;259(2):327-30 [6824943] J Pharmacol Exp Ther. 1981 Aug;218(2):421-5 [7252841] J Cereb Blood Flow Metab. 1991 Jan;11(1):135-42 [1845765] J Pharmacol Exp Ther. 1990 Oct;255(1):66-73 [2213572] J Pharmacol Exp Ther. 1985 Aug;234(2):442-6 [2410594] J Pharmacol Exp Ther. 1989 Jul;250(1):44-51 [2545867] J Cereb Blood Flow Metab. 1989 Oct;9(5):713-6 [2777937] Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):98-103 [2944005] FASEB J. 1987 Sep;1(3):177-85 [3040504] J Pharmacol Exp Ther. 1981 Jul;218(1):217-30 [6113280] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stages of change for smoking cessation among former problem drinkers: a cross-sectional analysis. AN - 73113270; 1504636 AB - Recent research suggests that problem drinkers are less successful in quitting smoking. Stages of change, decisional balance, and self-efficacy measures were used to assess readiness for smoking cessation in a cross-sectional sample of former problem drinkers who were current smokers. As was expected, a very high percentage of recovering problem drinkers had been or currently were regular smokers. Distributions across the stages of change and relationships between stages and decisional balance in this problem drinker sample was found to be similar to results from more general smoking populations. Of those who had quit both smoking and alcohol, 62% quit drinking before or at the same time as smoking (53% before; 9% simultaneous). Those who quit drinking before or at the same time as smoking were characterized by a more problematic alcohol history. A stages-of-change perspective with this group is discussed, as are new avenues for future research with such populations. JF - Journal of substance abuse AU - Snow, M G AU - Prochaska, J O AU - Rossi, J S AD - University of Connecticut Health Center, West Haven Veterans Administration Medical Center, CT 06516. Y1 - 1992 PY - 1992 DA - 1992 SP - 107 EP - 116 VL - 4 IS - 2 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Generalization (Psychology) KW - Adult KW - Temperance -- psychology KW - Alcohol Drinking -- psychology KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Smoking Cessation -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73113270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=Stages+of+change+for+smoking+cessation+among+former+problem+drinkers%3A+a+cross-sectional+analysis.&rft.au=Snow%2C+M+G%3BProchaska%2C+J+O%3BRossi%2C+J+S&rft.aulast=Snow&rft.aufirst=M&rft.date=1992-01-01&rft.volume=4&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-23 N1 - Date created - 1992-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiology considerations in peptic ulcer disease. AN - 73112405; 1498525 AB - Peptic ulcer disease is a common clinical problem. The lifetime risk of peptic ulcer disease is at least 10%. Millions of Americans are affected each year, imposing a major economic burden on the health care system. The overall hospitalization and mortality rates for peptic ulcer disease seem to have decreased substantially over the past few decades. There is much to suggest, however, that these changes were occurring even before effective medical therapy became available. In addition, other influences, such as increasing age of the population at risk, changes in smoking prevalence, and increasing use of nonsteroidal anti-inflammatory drugs, have impacted on the changing epidemiology of peptic ulcer disease. Hospitalization rates for patients with complications of peptic ulcer disease have remained relatively stable or, especially in the case of elderly women with gastric ulcers, increased significantly in recent years. Understanding the epidemiology of peptic ulcer disease will allow improved assessment of the effects of medical and surgical therapy and, hopefully, provide better clues to the etiology of this diverse group of diseases. JF - Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians AU - Schlesinger, P K AU - Robinson, B AU - Layden, T J AD - Department of Medicine, Veterans Administration West Side Medical Center, Chicago, IL. Y1 - 1992 PY - 1992 DA - 1992 SP - 70 EP - 77 VL - 3 IS - 3 SN - 1048-9886, 1048-9886 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - Office Visits KW - Hospitalization KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Smoking -- adverse effects KW - United States -- epidemiology KW - Male KW - Female KW - Peptic Ulcer -- epidemiology KW - Peptic Ulcer -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73112405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.atitle=Epidemiology+considerations+in+peptic+ulcer+disease.&rft.au=Schlesinger%2C+P+K%3BRobinson%2C+B%3BLayden%2C+T+J&rft.aulast=Schlesinger&rft.aufirst=P&rft.date=1992-01-01&rft.volume=3&rft.issue=3&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.issn=10489886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-17 N1 - Date created - 1992-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurotoxic effects of platinum compounds in cultured dorsal root ganglion cells. AN - 73060847; 1625039 AB - The neurotoxic cancer chemotherapeutic agent cis-diamminedichloroplatinum (II) (cis-platin) was tested in a model system of cultured embryonic chick dorsal root ganglion cells, in order to investigate cellular mechanisms of toxicity. At 7.5 ug/ml, the drug caused mild toxicity. At doses of 75 ug/ml, cis-platin was toxic to cultures in 6 hours, in both neuronal and non-neuronal cell populations. After 24 hours of incubation with 75 ug/ml cis-platin, there was extensive cell death. The trans isomer of the drug, trans-platin, was less toxic than cis-platin at similar doses, causing less severe damage to the cells as well as less cell death. With both drugs, abnormalities in patterns of nuclear staining were prominent, whereas neuronal cell membrane staining patterns were less affected. Both drugs seemed to affect non-neuronal cells to a greater extent than neurons. Ultrastructural findings with both drugs included nucleolar segregation; mitochondrial changes were nonspecific. In this in vitro system, both cis- and trans-platin are toxic. The toxicity appears to predominantly affect the nucleus, and to preferentially involve non-neuronal cells. JF - Journal of experimental pathology AU - Blisard, K S AU - Rogers, S L AU - Alexander, S AU - Harrington, D A AD - Research Service, Veterans' Administration Medical Center, Albuquerque, NM. Y1 - 1992 PY - 1992 DA - 1992 SP - 65 EP - 74 VL - 6 IS - 1-2 SN - 0730-8485, 0730-8485 KW - transplatin KW - 14913-33-8 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Chick Embryo KW - Cell Death -- drug effects KW - Time Factors KW - Ganglia, Spinal -- cytology KW - Cisplatin -- toxicity KW - Cisplatin -- pharmacology KW - Ganglia, Spinal -- drug effects KW - Cisplatin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73060847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+pathology&rft.atitle=Neurotoxic+effects+of+platinum+compounds+in+cultured+dorsal+root+ganglion+cells.&rft.au=Blisard%2C+K+S%3BRogers%2C+S+L%3BAlexander%2C+S%3BHarrington%2C+D+A&rft.aulast=Blisard&rft.aufirst=K&rft.date=1992-01-01&rft.volume=6&rft.issue=1-2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+pathology&rft.issn=07308485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-07 N1 - Date created - 1992-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Measurement issues in the evaluation of experimental treatment interventions. AN - 73048739; 1620195 AB - The final discussion of followup measurement highlights earlier discussions of patient and treatment measurement. Followup is the best assessment of the efficacy of a treatment intervention. Therefore, it is critical to have a clear set of baseline measures on the patient in those areas that are expected to be able to improve with the intervention and to repeat these measures at followup to assess improvement and outcome. The measures that are collected at followup are essentially identical to the measures that were collected at the time of treatment admission but in abbreviated form. However, the same methodological issues, techniques, and considerations apply. As at the time of the initial assessment, the patient should be measured in all those areas that are expected to be changed, the patient should be assessed with multiple methods (interview questionnaire and objective laboratory data), and all care should be taken to assure the patient that the information will be treated in a professional manner and that her privacy and confidentiality will be protected. An effective posttreatment evaluation requires effective tracking, locating, and reinterviewing each patient following treatment. The ability to recontact these patients after treatment is almost entirely dependent on the level of information, patient preparation, and interagency cooperation established during the time the patient was in treatment. Followup is an important but difficult job that must be coordinated from the very start of treatment and must involve the patient, followup staff, clinical program, and sponsoring agency or agencies. JF - NIDA research monograph AU - McLellan, A T AD - Penn-VA Center for Studies of Addiction, Philadelphia Veterans Administration Medical Center, PA 19104. Y1 - 1992 PY - 1992 DA - 1992 SP - 18 EP - 30 VL - 117 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Female KW - Pregnancy KW - Substance-Related Disorders -- therapy KW - Pregnancy Complications -- therapy KW - Pregnancy Complications -- prevention & control KW - Substance-Related Disorders -- complications KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73048739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Measurement+issues+in+the+evaluation+of+experimental+treatment+interventions.&rft.au=McLellan%2C+A+T&rft.aulast=McLellan&rft.aufirst=A&rft.date=1992-01-01&rft.volume=117&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-06 N1 - Date created - 1992-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypothalamic-pituitary function during alcohol exposure and withdrawal and cocaine exposure. AN - 72954739; 1317048 AB - This chapter examines the neuroendocrine effects of acute exposure to and withdrawal from alcohol and cocaine, with special emphasis on the hypothalamic-pituitary-adrenal (HPA) axis. We present the results from two preliminary controlled inpatient studies that document HPA dysfunction during acute exposure to alcohol and cocaine and during withdrawal from alcohol. We discuss the methodological approach of these studies in comparison to related attempts in the literature to use measures of thyroid and prolactin regulation to predict risk of relapse to alcohol and cocaine use, respectively. Our data and the results of related studies are presented in the context of a proposed index of HPA axis dysfunction that may provide a useful clinical measure of susceptibility to relapse during protracted abstinence from alcohol or cocaine. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Wilkins, J N AU - Gorelick, D A AU - Nademanee, K AU - Taylor, A AU - Herzberg, D S AD - Substance Abuse Service, West Los Angeles Veterans Administration Medical Center, Brentwood Division, California 90073. Y1 - 1992 PY - 1992 DA - 1992 SP - 57 EP - 71 VL - 10 SN - 0738-422X, 0738-422X KW - Ethanol KW - 3K9958V90M KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Cocaine KW - I5Y540LHVR KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Alcoholic Intoxication -- rehabilitation KW - Substance Abuse Treatment Centers KW - Double-Blind Method KW - Alcoholic Intoxication -- physiopathology KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Hydrocortisone -- blood KW - Adrenocorticotropic Hormone -- blood KW - Substance-Related Disorders -- physiopathology KW - Alcoholism -- rehabilitation KW - Hypothalamo-Hypophyseal System -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Substance-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects KW - Ethanol -- adverse effects KW - Ethanol -- pharmacokinetics KW - Substance Withdrawal Syndrome -- rehabilitation KW - Pituitary-Adrenal System -- physiopathology KW - Cocaine -- pharmacokinetics KW - Alcoholism -- physiopathology KW - Pituitary-Adrenal System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72954739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Hypothalamic-pituitary+function+during+alcohol+exposure+and+withdrawal+and+cocaine+exposure.&rft.au=Wilkins%2C+J+N%3BGorelick%2C+D+A%3BNademanee%2C+K%3BTaylor%2C+A%3BHerzberg%2C+D+S&rft.aulast=Wilkins&rft.aufirst=J&rft.date=1992-01-01&rft.volume=10&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-22 N1 - Date created - 1992-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol consumption and mortality in an American male population: recovering the U-shaped curve--findings from the normative Aging Study. AN - 72872043; 1556854 AB - Several prospective studies have suggested that moderate alcohol consumption may offer protection against total and coronary heart disease (CHD) mortality. These studies have been criticized for failing to control for changes in drinking and the influence of comorbidity on consumption decisions. In the present study, we examined whether rates of death from all causes and from CHD were related to overall consumption as well as variability in or problems with drinking. In 1973, a drinking questionnaire was completed by 1,823 male subjects participating in a longitudinal study who were prescreened for absence of serious or chronic disease. After 12 years of follow-up per subject (21,716 man years of follow-up in all), 159 men have died, 74 from CHD. Incidence rates of overall mortality were lowest for moderate drinkers in each of three age groups. CHD death rates for moderate drinkers were similar to those of non-drinkers except in the oldest men where rates were lower for moderate drinkers. Proportional hazards models testing several measures of consumption consistently showed moderate or regular drinkers to have lower risk of death than teetotalers. Regular drinkers had lower overall and CHD mortality than lifetime abstainers. For all-cause and CHD mortality, drinking heavily in the past, ever having tried to quit drinking and having had problems with alcohol were not related to increased risk. These results lend support to the hypothesis of the beneficial effect of moderate drinking, with respect to mortality. JF - Journal of studies on alcohol AU - de Labry, L O AU - Glynn, R J AU - Levenson, M R AU - Hermos, J A AU - LoCastro, J S AU - Vokonas, P S AD - Normative Aging Study, Veterans Administration Medical Center, Bedford, Massachusetts 01730. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 25 EP - 32 VL - 53 IS - 1 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Population KW - United States KW - North America KW - Heart Diseases KW - Americas KW - Alcohol Drinking--men KW - Population Dynamics KW - Developed Countries KW - Mortality--men KW - Northern America KW - Behavior KW - Demographic Factors KW - Health--men KW - Diseases KW - Risk Factors KW - Humans KW - Middle Aged KW - Follow-Up Studies KW - Boston -- epidemiology KW - Longitudinal Studies KW - Male KW - Alcoholism -- rehabilitation KW - Coronary Disease -- mortality KW - Alcohol Drinking -- mortality KW - Alcoholism -- mortality KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72872043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Alcohol+consumption+and+mortality+in+an+American+male+population%3A+recovering+the+U-shaped+curve--findings+from+the+normative+Aging+Study.&rft.au=de+Labry%2C+L+O%3BGlynn%2C+R+J%3BLevenson%2C+M+R%3BHermos%2C+J+A%3BLoCastro%2C+J+S%3BVokonas%2C+P+S&rft.aulast=de+Labry&rft.aufirst=L&rft.date=1992-01-01&rft.volume=53&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it. AN - 72871835; 1554971 AB - Aspirin (acetylsalicylic acid) and its salicylate derivatives are effective antipyretic, analgesic, and anti-inflammatory agents that are still very widely used by the elderly despite the advent of newer, potentially safer nonsteroidal anti-inflammatory drugs (NSAIDs). However, none of the new NSAIDs have been proven to be more effective than aspirin or salicylic acid. Chronic salicylate intoxication which is most common in the elderly, may occur with therapeutic doses. Increased toxicity in older patients often appears due to inadvertent overdosage. Dual prescribing or additional use of nonprescription salicylates are some causes of unwitting long term toxicity. According to some studies, systemic clearance of salicylate (mainly by hepatic metabolism) is reduced with age, as is renal elimination. These changes are of increased importance in the elderly using high therapeutic doses of salicylates when metabolism is saturated and more unchanged drug is available for renal excretion. In the face of renal impairment, the risk of toxicity is increased. The diagnosis of acute salicylate intoxication generally does not pose diagnostic problems. Patients often present with a history of intentional overdose, with hyperventilation, fever, and nausea. The diagnosis can be confirmed by measuring serum salicylate concentrations. Chronic intoxication often poses a diagnostic dilemma with atypical presentations mimicking other disease states such as diabetic ketoacidosis, delirium, cerebrovascular accident, myocardial infarction or cardiac failure. The diagnosis of salicylate intoxication should be borne in mind when an older patient presents with recent deterioration in activities of daily living with no known cause. Plasma salicylate concentrations should be measured if salicylate intoxication is suspected, even if there is no documented history of salicylate ingestion. The risk of salicylate nephrotoxicity is also increased with age, and upper gastrointestinal haemorrhage is associated with increased mortality in older age groups. Treatment of acute toxicity consists of prompt recognition of salicylate intoxication, use of activated charcoal, correction of acid-base abnormalities, general supportive measures, and if concentrations are extremely high, dialysis can be effectively used. Chronic toxicity, which can occur even with marginally high salicylate concentrations, is treated with drug withdrawal and supportive therapy. Chronic salicylate toxicity can be averted by prescription of conservative doses of drug, avoidance of concomitant use of different salicylate preparations, and therapeutic monitoring to guide dosage. Renal function should be monitored to detect nephrotoxicity from chronic salicylate therapy. Patients should be regularly screened for evidence of gastrointestinal bleeding.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Drugs & aging AU - Durnas, C AU - Cusack, B J AD - Veterans Administration Medical Center, Boise. PY - 1992 SP - 20 EP - 34 VL - 2 IS - 1 SN - 1170-229X, 1170-229X KW - Salicylates KW - 0 KW - Index Medicus KW - Drug Interactions KW - Gastrointestinal Diseases -- diagnosis KW - Humans KW - Gastrointestinal Diseases -- chemically induced KW - Aged KW - Gastrointestinal Diseases -- prevention & control KW - Poisoning -- prevention & control KW - Salicylates -- poisoning KW - Salicylates -- pharmacokinetics KW - Salicylates -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72871835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+%26+aging&rft.atitle=Salicylate+intoxication+in+the+elderly.+Recognition+and+recommendations+on+how+to+prevent+it.&rft.au=Durnas%2C+C%3BCusack%2C+B+J&rft.aulast=Durnas&rft.aufirst=C&rft.date=1992-01-01&rft.volume=2&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Drugs+%26+aging&rft.issn=1170229X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-05 N1 - Date created - 1992-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the MMPI-PTSD subscale with PTSD and substance abuse patient populations. AN - 72867447; 1556209 AB - War-related PTSD frequently presents as a dual disorder. Questions have been raised about whether the MMPI-PTSD subscale developed by Keane, Malloy, and Fairbank (1984) is identifying a separate PTSD syndrome or is a measure of generalized distress common to various diagnostic categories, including substance abuse. In this study, veterans with PTSD with and without substance abuse were compared to veterans with substance abuse only on the MMPI-PTSD subscale (n = 22 in each of the four categories). Results support the ability of the test to distinguish between groups of veterans with PTSD and those with substance abuse only. The findings lend indirect support to the validity of a distinct PTSD symptom cluster. JF - Journal of clinical psychology AU - Kenderdine, S K AU - Phillips, E J AU - Scurfield, R M AD - Veterans Administration Medical Center, Tacoma, Washington. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 136 EP - 139 VL - 48 IS - 1 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Humans KW - Follow-Up Studies KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Combat Disorders -- psychology KW - Hospitalization KW - Alcoholism -- diagnosis KW - MMPI -- statistics & numerical data KW - Combat Disorders -- diagnosis KW - Combat Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72867447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Comparison+of+the+MMPI-PTSD+subscale+with+PTSD+and+substance+abuse+patient+populations.&rft.au=Kenderdine%2C+S+K%3BPhillips%2C+E+J%3BScurfield%2C+R+M&rft.aulast=Kenderdine&rft.aufirst=S&rft.date=1992-01-01&rft.volume=48&rft.issue=1&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-01 N1 - Date created - 1992-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat. AN - 72840881; 1542888 AB - Chronic lead exposure may cause hypertension in normotensive rats. This hypertensinogenic effect has been attributed to perturbations in the renin-angiotensin axis, the contractile response of the vascular smooth muscle, or the intracellular Ca2+ homeostasis as a consequence of the inhibition of Na(+)-K(+)-ATPase activity. In this study we examined the short-term effect of lead exposure on blood pressure, plasma renin activity, vascular contractility, and renal Na(+)-K(+)-ATPase activity and abundance in the spontaneously hypertensive rat. Our data indicate that modest lead exposure caused blood pressure elevation within two weeks in this rat strain that is genetically susceptible to the development of hypertension. This rapid blood pressure-elevating effect did not appear to depend on the mechanisms described in hypertension associated with more chronic lead exposure listed above. This acute model provides an additional approach to the study of lead-induced hypertension. JF - Toxicology and industrial health AU - Nakhoul, F AU - Kayne, L H AU - Brautbar, N AU - Hu, M S AU - McDonough, A AU - Eggena, P AU - Golub, M S AU - Berger, M AU - Chang, C T AU - Jamgotchian, N AD - Veterans Administration Medical Center, Sepulveda, California. PY - 1992 SP - 89 EP - 102 VL - 8 IS - 1-2 SN - 0748-2337, 0748-2337 KW - Lead KW - 2P299V784P KW - Renin KW - EC 3.4.23.15 KW - Index Medicus KW - Rats KW - Body Weight KW - Animals KW - Renin -- metabolism KW - Rats, Inbred SHR KW - Femoral Artery -- physiology KW - Male KW - Lead -- urine KW - Hypertension -- chemically induced KW - Lead -- toxicity KW - Environmental Exposure KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72840881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Rapid+hypertensinogenic+effect+of+lead%3A+studies+in+the+spontaneously+hypertensive+rat.&rft.au=Nakhoul%2C+F%3BKayne%2C+L+H%3BBrautbar%2C+N%3BHu%2C+M+S%3BMcDonough%2C+A%3BEggena%2C+P%3BGolub%2C+M+S%3BBerger%2C+M%3BChang%2C+C+T%3BJamgotchian%2C+N&rft.aulast=Nakhoul&rft.aufirst=F&rft.date=1992-01-01&rft.volume=8&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-07 N1 - Date created - 1992-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Electrophysiological effects of phencyclidine and the sigma agonist ditolylguanidine in the cerebellum of the rat. AN - 72830642; 1311809 AB - The electrophysiological actions of phencyclidine (PCP) and the sigma agonist 1,3-di(2tolyl)guanidine (DTG) were examined in the cerebellum of urethane-anesthetized rats. The object of the study was to determine if PCP and sigma agonists shared a common mechanism of action. The cerebellar Purkinje neuron was chosen because it has sigma receptors but not N-methyl-D-aspartate receptors, where PCP has additional effects. Both DTG and PCP decreased the spontaneous discharge rate of cerebellar Purkinje neurons after parenteral administration. When the drugs were applied locally to single Purkinje neurons, using pressure ejection through multibarrel micropipettes, both compounds decreased the spontaneous activity of the neurons with equal potency. Previous studies have shown that the actions of PCP in the cerebellum are dependent upon an interaction with noradrenergic terminals from the nucleus locus coeruleus. A similar finding was made in this study for DTG. Elimination of the noradrenergic input by lesion with the neurotoxin, 6-hydroxydopamine, diminished equally the effects of PCP and DTG. Treatment of the animals with haloperidol had similar effects. It is concluded that PCP and the sigma agonist DTG both act as indirect noradrenergic agonists in the cerebellum. JF - Neuropharmacology AU - Kim, M AU - Bickford, P C AD - Denver Veterans Administration Medical Center, CO 80776. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 77 EP - 83 VL - 31 IS - 1 SN - 0028-3908, 0028-3908 KW - Guanidines KW - 0 KW - Oxidopamine KW - 8HW4YBZ748 KW - Phencyclidine KW - J1DOI7UV76 KW - Haloperidol KW - J6292F8L3D KW - 1,3-ditolylguanidine KW - LL2P01I17O KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Purkinje Fibers -- drug effects KW - Norepinephrine -- physiology KW - Animals KW - Synaptic Transmission -- drug effects KW - Haloperidol -- pharmacology KW - Electrophysiology KW - Male KW - Oxidopamine -- pharmacology KW - Cerebellum -- drug effects KW - Phencyclidine -- pharmacology KW - Guanidines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72830642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Electrophysiological+effects+of+phencyclidine+and+the+sigma+agonist+ditolylguanidine+in+the+cerebellum+of+the+rat.&rft.au=Kim%2C+M%3BBickford%2C+P+C&rft.aulast=Kim&rft.aufirst=M&rft.date=1992-01-01&rft.volume=31&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-08 N1 - Date created - 1992-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trophic regulation of acetylcholinesterase isoenzymes in adult mammalian skeletal muscles. AN - 72820393; 1311432 AB - This work addresses the physiological regulation of skeletal muscle acetylcholinesterase (AChE) isoforms by examining endplate-enriched samples from adult rat gracilis muscles 48 h after: low-intensity treadmill exercise; obturator nerve transection; nerve impulse conduction blockade by tetrodotoxin; acetylcholine (ACh) receptor (AChR) inactivation by alpha-bungarotoxin; and, addition of obturator nerve extracts to muscles in organ culture. Results document the important role(s) of functional AChRs and ACh-AChR interactions in the differential control of individual AChE isoenzymes. A theoretical model based on these and other findings considers that: AChR activation by spontaneously released ACh is the only neural factor required for the maintenance of G1 + G2 AChE; the amount of A12 AChE is determined by the combined effects of ACh and another neurogenic substance; although mechanisms intrinsic to myofibers control normal levels of G4 AChE, enhanced production of this isoform is initiated through increasing the frequency of ACh-AChR interactions. JF - Neurochemical research AU - Fernandez, H L AU - Hodges-Savola, C A AD - Neuroscience Research Laboratory, U.S. Department of Veterans Affairs Medical Center, Kansas City, Missouri 64128. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 115 EP - 124 VL - 17 IS - 1 SN - 0364-3190, 0364-3190 KW - Bungarotoxins KW - 0 KW - Cholinergic Antagonists KW - Isoenzymes KW - Receptors, Cholinergic KW - Tetrodotoxin KW - 4368-28-9 KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Index Medicus KW - Space life sciences KW - Animals KW - Motor Activity -- physiology KW - Motor Endplate -- enzymology KW - Obturator Nerve -- surgery KW - Bungarotoxins -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Physical Exertion KW - Receptors, Cholinergic -- physiology KW - Obturator Nerve -- physiology KW - Tetrodotoxin -- pharmacology KW - Organ Culture Techniques KW - Synaptic Transmission KW - Acetylcholinesterase -- metabolism KW - Muscles -- enzymology KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72820393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Trophic+regulation+of+acetylcholinesterase+isoenzymes+in+adult+mammalian+skeletal+muscles.&rft.au=Fernandez%2C+H+L%3BHodges-Savola%2C+C+A&rft.aulast=Fernandez&rft.aufirst=H&rft.date=1992-01-01&rft.volume=17&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-02 N1 - Date created - 1992-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ribosomal RNA activity and protein in skeletal muscles of chronic ethanol-fed rats. AN - 72789708; 1733428 AB - The effect of prolonged ethanol exposure on ribosomal RNA activity and the content of RNA and protein in skeletal muscles of 15- and 22-25-month-old rats was evaluated. Experimental rats were fed a liquid diet containing 6.7% ethanol for 2, 4 and 6 months, and control rats were pair-fed an isocaloric diet. The in vivo incorporation of [3H]puromycin into nascent peptides on messenger RNA-ribosome complexes was determined to assess muscle ribosomal RNA activity. This activity was significantly reduced in extensor digitorum longus and soleus muscles of rats fed ethanol for 2 months. While the total RNA content of these muscles was unchanged after feeding ethanol for 2, 4 and 6 months, their messenger RNA content was decreased from 26-34%. The total protein content was reduced after ethanol was consumed for 6 months. Taken together, the results suggest that alterations in the transcriptional or posttranscriptional control of messenger RNA may contribute toward the development of alcoholic myopathy after prolonged ethanol consumption. JF - Alcohol (Fayetteville, N.Y.) AU - Held, I R AD - Neuroscience Research Laboratory, Veterans Administration Hospital, Hines, IL 60141. PY - 1992 SP - 79 EP - 82 VL - 9 IS - 1 SN - 0741-8329, 0741-8329 KW - Muscle Proteins KW - 0 KW - RNA, Messenger KW - RNA, Ribosomal KW - Ethanol KW - 3K9958V90M KW - Puromycin KW - 4A6ZS6Q2CL KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - RNA, Messenger -- metabolism KW - Puromycin -- metabolism KW - Male KW - Muscle Proteins -- metabolism KW - RNA, Ribosomal -- metabolism KW - Ethanol -- pharmacology KW - Muscles -- metabolism KW - Ethanol -- administration & dosage KW - Alcoholism -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72789708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Ribosomal+RNA+activity+and+protein+in+skeletal+muscles+of+chronic+ethanol-fed+rats.&rft.au=Held%2C+I+R&rft.aulast=Held&rft.aufirst=I&rft.date=1992-01-01&rft.volume=9&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-03 N1 - Date created - 1992-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Erythromycin ototoxicity: prospective assessment with serum concentrations and audiograms in a study of patients with pneumonia. AN - 72777991; 1731511 AB - The incidence and risk factors for erythromycin-induced ototoxicity are unknown. We conducted a prospective, nested case-control study of assessment of auditory function in patients receiving erythromycin versus other antibiotics (control group) for community-acquired pneumonia. Sequential audiograms were performed during antibiotic therapy for both cases and controls by an audiologist unaware of the identity of the therapy administered. Erythromycin serum concentrations were obtained for all patients receiving erythromycin. Symptomatic ototoxicity (tinnitus or hearing loss) confirmed by audiograms was documented in five of 30 patients receiving erythromycin and none of 15 receiving other antibiotics. Ototoxicity was significantly related to high peak concentration and high AUC 0-infinity as a function of decreased total systemic clearance. Ototoxicity occurred only in those patients who received 4 g/day versus 2 g/day or no erythromycin (p = 0.05). Ototoxicity resolved in all patients within 6 to 14 days after discontinuation of therapy. Erythromycin ototoxicity is dose- and serum concentration-dependent. Patients receiving erythromycin, especially at a total daily dose of 4 g, should be monitored regularly for subjective evidence of sensorineural hearing dysfunction. Ototoxicity is reversible if the diagnosis is made early in the course. JF - The American journal of medicine AU - Swanson, D J AU - Sung, R J AU - Fine, M J AU - Orloff, J J AU - Chu, S Y AU - Yu, V L AD - Department of Pharmacy Practice, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 61 EP - 68 VL - 92 IS - 1 SN - 0002-9343, 0002-9343 KW - Erythromycin KW - 63937KV33D KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Hearing Loss, Sensorineural -- chemically induced KW - Audiometry KW - Humans KW - Adult KW - Hearing Loss, Bilateral -- chemically induced KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Tinnitus -- chemically induced KW - Pneumonia -- blood KW - Erythromycin -- adverse effects KW - Hearing Disorders -- blood KW - Hearing Disorders -- chemically induced KW - Pneumonia -- drug therapy KW - Erythromycin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72777991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Erythromycin+ototoxicity%3A+prospective+assessment+with+serum+concentrations+and+audiograms+in+a+study+of+patients+with+pneumonia.&rft.au=Swanson%2C+D+J%3BSung%2C+R+J%3BFine%2C+M+J%3BOrloff%2C+J+J%3BChu%2C+S+Y%3BYu%2C+V+L&rft.aulast=Swanson&rft.aufirst=D&rft.date=1992-01-01&rft.volume=92&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Med. 1993 Feb;94(2):227-9 [8430720] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects. AN - 72775508; 1731046 AB - Studies were conducted to investigate the clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects. Each of 20 male patients stabilized on 24 mg of methadone daily received two i.v. pharmacological challenges: one with naloxone (0.05, 0.10, 0.15 and 0.20 mg; five patients each dose), and one with saline placebo. Measures of opioid withdrawal, affective state, cognitive performance and changes in autonomic parameters were assessed after each pharmacological challenge. Naloxone produced dose-dependent increases in opiate withdrawal scale scores and in symptoms of dysphoria as measured by the Profile of Mood States. Differences within subjects between naloxone and placebo infusions in Profile of Mood States scores were highly correlated with differences in opioid withdrawal as assessed by both subjective and objective rating scales. Naloxone also produced substantial increases in pulse, systolic and diastolic blood pressure and respiratory rate, as well as a small decrease in temperature. However, naloxone-induced changes from base-line values in these autonomic parameters correlated only modestly with other measures of opioid withdrawal. No differences between infusions were observed in two measures of cognitive performance (Stroop Color and Word Test, Digit Span Test). The results indicate that dysphoric mood states reflecting a broad range of affective experience must be considered as integral components of the naloxone-precipitated opioid withdrawal syndrome. JF - The Journal of pharmacology and experimental therapeutics AU - Kanof, P D AU - Handelsman, L AU - Aronson, M J AU - Ness, R AU - Cochrane, K J AU - Rubinstein, K J AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, NY. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 355 EP - 363 VL - 260 IS - 1 SN - 0022-3565, 0022-3565 KW - Narcotics KW - 0 KW - Naloxone KW - 36B82AMQ7N KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Infusions, Intravenous KW - Cognition -- drug effects KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Respiration -- drug effects KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Substance Withdrawal Syndrome -- physiopathology KW - Naloxone -- therapeutic use KW - Substance Withdrawal Syndrome -- drug therapy KW - Narcotics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72775508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Clinical+characteristics+of+naloxone-precipitated+withdrawal+in+human+opioid-dependent+subjects.&rft.au=Kanof%2C+P+D%3BHandelsman%2C+L%3BAronson%2C+M+J%3BNess%2C+R%3BCochrane%2C+K+J%3BRubinstein%2C+K+J&rft.aulast=Kanof&rft.aufirst=P&rft.date=1992-01-01&rft.volume=260&rft.issue=1&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy. AN - 72755237; 1727388 AB - The purpose of this study was to investigate whether substrate deprivation acutely and selectively decreases ATP concentration in an experimental sarcoma. Two methods of substrate deprivation were examined: glycolysis was inhibited using 2-deoxyglucose (2DG), and plasma substrate levels were reduced using insulin. The effects of treatment on tumor ATP, inorganic phosphate, and pH were studied by 31P nuclear magnetic resonance spectroscopy. 2DG (2 g/kg) was administered i.p. to rats bearing s.c. methylcholanthrene-induced sarcomas. Inhibition of glycolysis by 2DG caused a 52 +/- 13% (SE) decrease in the tumor ATP to inorganic phosphate ratio, associated with a decrease in pH of 0.38 +/- 0.10 unit. The same dose of 2DG caused no significant change in the ratio of phosphocreatine to ATP in brain. Insulin (125 units/kg, i.p.) caused a 68% decline in plasma glucose and a 71% decline in betahydroxybutyrate compared to saline-treated animals. Concomitantly, 31P nuclear magnetic resonance spectroscopy detected a 48 +/- 13% decrease in sarcoma ATP, with a reciprocal elevation of inorganic phosphate in insulin-treated animals. In contrast, the brain phosphocratine/ATP ratio was unaffected by insulin. These results suggest that large tumors are acutely sensitive to inhibition of glycolysis and reductions in plasma levels of substrates for oxidative phosphorylation and glycolysis, while the brain is unaffected. In addition, this work provides support for the use of 31P nuclear magnetic resonance spectroscopy to monitor tumor response to therapy. JF - Cancer research AU - Karczmar, G S AU - Arbeit, J M AU - Toy, B J AU - Speder, A AU - Weiner, M W AD - Magnetic Resonance Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1992/01/01/ PY - 1992 DA - 1992 Jan 01 SP - 71 EP - 76 VL - 52 IS - 1 SN - 0008-5472, 0008-5472 KW - Insulin KW - 0 KW - Phosphorus KW - 27YLU75U4W KW - Methylcholanthrene KW - 56-49-5 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Brain -- metabolism KW - Male KW - Magnetic Resonance Spectroscopy KW - Sarcoma, Experimental -- chemically induced KW - Sarcoma, Experimental -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Insulin -- pharmacology KW - Deoxyglucose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72755237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Selective+depletion+of+tumor+ATP+by+2-deoxyglucose+and+insulin%2C+detected+by+31P+magnetic+resonance+spectroscopy.&rft.au=Karczmar%2C+G+S%3BArbeit%2C+J+M%3BToy%2C+B+J%3BSpeder%2C+A%3BWeiner%2C+M+W&rft.aulast=Karczmar&rft.aufirst=G&rft.date=1992-01-01&rft.volume=52&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-17 N1 - Date created - 1992-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potentiation of acute acetaminophen lethality by selenium and vitamin E deficiency in mice. AN - 72733558; 1729474 AB - The effects of selenium, vitamin E, and DL-methionine deficiency on the acute lethality and hepatotoxicity of acetaminophen in male CD-1 mice were studied. Vitamin E and selenium deficiencies led to an increase in the acute lethality of acetaminophen, with a decrease in the LD50 from 376 to 84 mg/kg. These dietary deficiencies impaired the inducibility of the hepatic microsomal mixed function oxidase system by phenobarbital, but on the basis of the covalent binding of acetaminophen to microsomes, these treatments did not alter the activation of acetaminophen to a reactive intermediate by this system. Addition of methionine to the deficient diet restored hepatic glutathione content to control levels but did little to protect against the acute lethality of acetaminophen. In methionine-supplemented animals, the addition of either selenium or vitamin E increased the LD50 of acetaminophen to 167 and 200 mg/kg, respectively. Administration of a sublethal, toxic dose of acetaminophen (LD30) to the methionine-supplemented and selenium- and vitamin E-deficient mice did not produce any hepatic damage as evidenced by a lack of plasma aminotransferase elevation. In view of the known antioxidant effects of vitamin E and selenium, these data suggest the involvement of a reactive radical in the acute lethality of acetaminophen and further suggest that death from acute acetaminophen overdose in chronic selenium- and vitamin E-deficient mice may be unrelated to liver necrosis. JF - The Journal of nutrition AU - Peterson, F J AU - Lindemann, N J AU - Duquette, P H AU - Holtzman, J L AD - Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 74 EP - 81 VL - 122 IS - 1 SN - 0022-3166, 0022-3166 KW - Acetaminophen KW - 362O9ITL9D KW - Methionine KW - AE28F7PNPL KW - Mixed Function Oxygenases KW - EC 1.- KW - Selenium KW - H6241UJ22B KW - Index Medicus KW - Body Weight KW - Animals KW - Mixed Function Oxygenases -- metabolism KW - Methionine -- deficiency KW - Lethal Dose 50 KW - Mice KW - Drug Synergism KW - Male KW - Selenium -- deficiency KW - Liver -- enzymology KW - Liver -- drug effects KW - Vitamin E Deficiency -- metabolism KW - Liver -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72733558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Potentiation+of+acute+acetaminophen+lethality+by+selenium+and+vitamin+E+deficiency+in+mice.&rft.au=Peterson%2C+F+J%3BLindemann%2C+N+J%3BDuquette%2C+P+H%3BHoltzman%2C+J+L&rft.aulast=Peterson&rft.aufirst=F&rft.date=1992-01-01&rft.volume=122&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-11 N1 - Date created - 1992-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outcome Study: Comparison of Short-Term vs Long-Term Treatment in a Residential Community AN - 61597520; 199200393 AB - To compare the effectiveness of long- vs short-term treatment for drug addicts, a study was conducted of 38 male patients admitted to a 3-month residential treatment center (RTC) at the Veterans Administration Medical Center in West Los Angeles, Calif, in 1985, who were surveyed 6 months after discharge. Results are compared to a similar study conducted in 1973 at the same location, with a 1-year length of stay. The comparison reveals differences in age, race, marital status, & drugs of abuse. Results show that the 12-month program had a 26% failure rate, compared to the 1985 failure rate of 47%. It is concluded that the longer program appears to be nearly twice as effective as the 3-month program. 4 Tables, 1 Figure, 11 References. S. Dilts JF - The International Journal of the Addictions AU - Charuvastra, V Charles AU - Dalali, Isobel Day AU - Cassuci, Michael AU - Ling, Walter AD - Veterans Administration Medical Center, 11301 Wilshire Blvd Los Angeles CA 90073 Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 15 EP - 23 VL - 27 IS - 1 SN - 0020-773X, 0020-773X KW - long- vs short-term residential drug treatment programs, male patients KW - 1973/1985 medical records/survey data KW - Veterans Administration Medical Center, West Los Angeles, California KW - Treatment Outcomes KW - Drug Addiction KW - Treatment Programs KW - Males KW - Residential Institutions KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61597520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+the+Addictions&rft.atitle=Outcome+Study%3A+Comparison+of+Short-Term+vs+Long-Term+Treatment+in+a+Residential+Community&rft.au=Charuvastra%2C+V+Charles%3BDalali%2C+Isobel+Day%3BCassuci%2C+Michael%3BLing%2C+Walter&rft.aulast=Charuvastra&rft.aufirst=V&rft.date=1992-01-01&rft.volume=27&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+the+Addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Drug Addiction; Treatment Programs; Treatment Outcomes; Residential Institutions; Males ER - TY - JOUR T1 - Social Resource Characteristics and Adolescent Substance Abuse Relapse AN - 61312107; 9306754 AB - Examines social resource networks of adolescent substance abusers to determine whether the abuse, perceived similarity, or perceived support of individuals in those networks are associated with relapse rates. Surveys completed by 20 teens in residential treatment in San Diego (Calif) County & a resource person (usually a parent) investigated history & current functioning. Individual diagnostic & social network interviews were administered, with follow-up interviews occurring 3 months after hospital discharge. It was found that perceived similarity to one's social network was critical to the degree of influence that network had on either relapse or continued abstinence. Relapse was most common in Ss who perceived themselves as similar to a network comprised of other abusers. 2 Tables, 3 Figures, 33 References. Adapted from the source document. JF - Journal of Adolescent Chemical Dependency AU - Vik, Peter W AU - Grizzle, Kenneth L AU - Brown, Sandra A AD - c/o Brown -- Psychology Service Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 59 EP - 74 VL - 2 IS - 2 SN - 0896-7768, 0896-7768 KW - social resource networks-relapse rate relationship, adolescent substance abusers KW - survey/other data KW - San Diego County, California KW - Substance Abuse KW - Social Networks KW - Recidivism KW - Adolescents KW - Resources KW - article KW - 1939: the family and socialization; adolescence & youth KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61312107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Chemical+Dependency&rft.atitle=Social+Resource+Characteristics+and+Adolescent+Substance+Abuse+Relapse&rft.au=Vik%2C+Peter+W%3BGrizzle%2C+Kenneth+L%3BBrown%2C+Sandra+A&rft.aulast=Vik&rft.aufirst=Peter&rft.date=1992-01-01&rft.volume=2&rft.issue=2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Chemical+Dependency&rft.issn=08967768&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JACDEM N1 - SubjectsTermNotLitGenreText - Substance Abuse; Adolescents; Resources; Social Networks; Recidivism ER - TY - JOUR T1 - A Retrospective Evaluation of Factors Influencing Successful Outcomes on an Inpatient Psychiatric Crisis Unit AN - 1761715852; 199200073 AB - A retrospective review of the hospital records of 69 patients on a short-term crisis intervention unit was conducted to differentiate the characteristics of the 41 patients who were successfully discharged to the community vs the 28 who required placement in a long-term care unit. Results indicate that treatment compliance & family support were significant factors associated with successful program completion. 2 Tables, 6 References. Adapted from the source document. JF - Research on Social Work Practice AU - Anthony, Dominic J, Jr AD - Social Work Dept West Haven Veterans Administration Medical Center, 950 Campbell Ave CT 06516 Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 56 EP - 64 VL - 2 IS - 1 SN - 1049-7315, 1049-7315 KW - short-term psychiatric crisis intervention unit's success, hospital, patient characteristics KW - retrospective record review KW - Crisis Intervention KW - Treatment Outcomes KW - Mental Patients KW - Client Characteristics KW - Treatment Compliance KW - Mental Hospitals KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761715852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+on+Social+Work+Practice&rft.atitle=A+Retrospective+Evaluation+of+Factors+Influencing+Successful+Outcomes+on+an+Inpatient+Psychiatric+Crisis+Unit&rft.au=Anthony%2C+Dominic+J%2C+Jr&rft.aulast=Anthony&rft.aufirst=Dominic&rft.date=1992-01-01&rft.volume=2&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Research+on+Social+Work+Practice&rft.issn=10497315&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Patients; Client Characteristics; Mental Hospitals; Crisis Intervention; Treatment Compliance; Treatment Outcomes ER - TY - JOUR T1 - Data Collection: Are Social Workers Reliable? AN - 1761713012; 199301829 AB - Personal information about social services clients & their families that may be unrelated to direct clinical work is nonetheless needed for purposes of payment, service documentation, agency planning, & accountability. The worker's concern about the appropriateness of collecting this data may result in poor compliance or even falsification of information. Questionnaire data from 244 social workers show that noncompliance with data collection requirements was substantial. There was also a significant degree of conflict about privacy & confidentiality issues. These findings suggest a basis of concern for those who must rely on accurate data for administrative planning. 3 Figures, 7 References. Adapted from the source document. JF - Administration in Social Work AU - O'Brien, Nancy AU - McClellan, Thomas AU - Alfs, Diane AD - Dept Social Work Veterans Administration Medical Center, 1 Veterans Dr Minneapolis MN 55417 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 89 EP - 99 VL - 16 IS - 2 SN - 0364-3107, 0364-3107 KW - social services clients, social workers' data collection requirement noncompliance KW - questionnaire data KW - Minnesota KW - Client Relations KW - Client Characteristics KW - Social Workers KW - Compliance KW - Data Collection KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761713012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Social+Work&rft.atitle=Data+Collection%3A+Are+Social+Workers+Reliable%3F&rft.au=O%27Brien%2C+Nancy%3BMcClellan%2C+Thomas%3BAlfs%2C+Diane&rft.aulast=O%27Brien&rft.aufirst=Nancy&rft.date=1992-01-01&rft.volume=16&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Administration+in+Social+Work&rft.issn=03643107&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Minnesota; Social Workers; Client Relations; Client Characteristics; Data Collection; Compliance ER - TY - JOUR T1 - Assessing Health Care Delivery to Male versus Female Veterans AN - 1761712144; 199202478 AB - To explore allegations that female (F) veterans have not received the same quality of care as male (M) veterans in US Dept of Veterans Affairs (VA) hospitals, a chart review of 48 M & 66 F inpatients, & telephone interviews with 55 veterans treated at a large metropolitan VA hospital Nov 1988-Apr 1989 were conducted. Chart documentation was poor, regardless of gender. On average, 67% of Ms & Fs received regular gender-specific examinations, although the number was somewhat lower for Fs. Both women & men were quite satisfied with the care received. Future studies should focus on the evaluation of workable solutions to providing equitable health care to women veterans. 3 Tables, 16 References. Adapted from the source document. JF - Women and Health AU - Turpin, Robin S AU - Darcy, Laurie A AU - Weaver, Frances M AU - Kruse, Katharine AD - Health Services Research & Development Field Program Veterans Administration Hospital, Hines IL 60141 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 81 EP - 95 VL - 18 IS - 1 SN - 0363-0242, 0363-0242 KW - health care quality assessment, male vs female veterans KW - 1988/89 interviews/chart reviews KW - US Veterans Administration hospital patients KW - Veterans KW - Sexual Inequality KW - Health Care KW - Government Agencies KW - Sex Differences KW - United States of America KW - Hospitals KW - article KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761712144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+and+Health&rft.atitle=Assessing+Health+Care+Delivery+to+Male+versus+Female+Veterans&rft.au=Turpin%2C+Robin+S%3BDarcy%2C+Laurie+A%3BWeaver%2C+Frances+M%3BKruse%2C+Katharine&rft.aulast=Turpin&rft.aufirst=Robin&rft.date=1992-01-01&rft.volume=18&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Women+and+Health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care; Sex Differences; United States of America; Veterans; Government Agencies; Hospitals; Sexual Inequality ER - TY - JOUR T1 - Attitudes toward Mandatory Human Immunodeficiency Virus Testing and Contact Tracing: A Survey of Intravenous Drug Users in Treatment AN - 1761710422; 199200540 AB - Interview & self-report questionnaire data are used to investigate attitudes toward mandatory human immunodeficiency virus (HIV) testing & contact tracing among 196 methadone-maintained patients from 2 Philadelphia (Pa) clinics. Findings indicate that although most methadone patients supported mandatory testing, their support was influenced by past testing experience; ie, significantly more untested than tested individuals were opposed to the policy. Regarding contact tracing, results indicate that most patients with seronegative results supported tracing, but of the 3 patients with seropositive results surveyed, 2 were opposed to it. However, most seropositive & seronegative patients reported a willingness to comply with tracing if it were to become law. 11 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - DePhilippis, Dominick AU - Metzger, David S AU - Woody, George E AU - Navaline, Helen A AD - Philadelphia Veterans Administration Medical Center, University & Woodland Aves PA 19104 Y1 - 1992///0, PY - 1992 DA - 0, 1992 SP - 39 EP - 42 VL - 9 IS - 1 SN - 0740-5472, 0740-5472 KW - human immunodeficiency virus, testing/contact tracing, methadone patients' attitudes KW - interview/questionnaire data KW - Philadelphia, Pennsylvania KW - Attitudes KW - Tests KW - Acquired Immune Deficiency Syndrome KW - Patients KW - Public Policy KW - Methadone Maintenance KW - article KW - 6123: self-help support groups/networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761710422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Attitudes+toward+Mandatory+Human+Immunodeficiency+Virus+Testing+and+Contact+Tracing%3A+A+Survey+of+Intravenous+Drug+Users+in+Treatment&rft.au=DePhilippis%2C+Dominick%3BMetzger%2C+David+S%3BWoody%2C+George+E%3BNavaline%2C+Helen+A&rft.aulast=DePhilippis&rft.aufirst=Dominick&rft.date=1992-01-01&rft.volume=9&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Philadelphia, Pennsylvania; Public Policy; Acquired Immune Deficiency Syndrome; Tests; Methadone Maintenance; Patients; Attitudes ER - TY - JOUR T1 - Alcoholism in older persons: A review of the literature AN - 16682808; 3052400 AB - Alcohol abuse and dependence in elderly persons is of growing social concern. The most consistent findings of cross-sectional and longitudinal studies are that the quantity and frequency of alcohol consumption is higher in elderly men than in elderly women, as is the prevalence of alcohol-related problems. Most studies show a decrease with age in consumption and alcohol-related problems among heavy drinkers. Longitudinal studies show no changes in consumption among light drinkers. Elderly persons with lower incomes consume less alcohol than those with higher incomes. Hospitalized and outpatient populations have more problem drinkers, and the elderly alcoholic is at greater risk for medical and psychiatric comorbidity. About one-third to one-half of elderly alcoholics experience the onset of problem drinking in middle or late life. Outcomes seem to be better for those who have late-onset drinking and may be improved for those treated in same-age rather than mixed-age groups. JF - HOSP. COMMUNITY PSYCHIATRY AU - Liberto, J G AU - Oslin, D W AU - Ruskin, P E AD - Spec. Popul. Geriatr. Subst. Abuse Program, Veterans Administration Med. Cent., 3900 Loch Raven Blvd., Baltimore, MD 21218, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 975 EP - 984 VL - 43 IS - 10 SN - 0022-1597, 0022-1597 KW - gerontology KW - substance abuse KW - alcoholism KW - Risk Abstracts KW - socioeconomics KW - gender KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16682808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HOSP.+COMMUNITY+PSYCHIATRY&rft.atitle=Alcoholism+in+older+persons%3A+A+review+of+the+literature&rft.au=Liberto%2C+J+G%3BOslin%2C+D+W%3BRuskin%2C+P+E&rft.aulast=Liberto&rft.aufirst=J&rft.date=1992-01-01&rft.volume=43&rft.issue=10&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=HOSP.+COMMUNITY+PSYCHIATRY&rft.issn=00221597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - gender; socioeconomics ER - TY - JOUR T1 - High-performance liquid chromatography of bile acids effect of hydroxyl groups at C-3, 6, 7 and 12 on bile acid mobility. AN - 16503711; 42965 AB - The high-performance liquid chromatographic characteristics of a number of bile acids with hydroxyl groups at C-3, 6, 7 and 12 positions are reported. Using Nova-pak C sub(18) reversed-phased columns and mobile phase consisting of acetonitrile/water/methanol/acetic acid mixtures, it was found that compounds with beta -hydroxyl groups were eluted much earlier than those with alpha -hydroxyl groups. Introduction of a hydroxyl group caused a marked increase in polarity of the bile acid, however, the effect was not well defined in bile acids with vicinal glycol system at C-6,7. The retention volumes of the various bile acids were reproducible and can be useful for characterization of bile acids in biological fluids. JF - Journal of Liquid Chromatography AU - Batta, Ashok K AU - Aggarwal, Suresht K AU - Salen, Gerald AD - Veterans Administration Medical Cent, East Orange, NJ, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 467 EP - 478 VL - 15 IS - 3 SN - 0148-3919, 0148-3919 KW - Acetic acid KW - Acetonitrile KW - Bile acids KW - Biological materials KW - Chenodeoxycholic acid KW - Cholic acid KW - Deoxycholic acid KW - High performance liquid chromatography KW - Hyocholic acid KW - Hyodeoxycholic acid KW - Lithocholic acid KW - Methanol KW - Ursodeoxycholic acid KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Water KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 804.1:ORGANIC COMPOUNDS KW - W 30965:Miscellaneous, Reviews KW - W4 801.1:CHEMISTRY (GENERAL) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16503711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liquid+Chromatography&rft.atitle=High-performance+liquid+chromatography+of+bile+acids+effect+of+hydroxyl+groups+at+C-3%2C+6%2C+7+and+12+on+bile+acid+mobility.&rft.au=Batta%2C+Ashok+K%3BAggarwal%2C+Suresht+K%3BSalen%2C+Gerald&rft.aulast=Batta&rft.aufirst=Ashok&rft.date=1992-01-01&rft.volume=15&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liquid+Chromatography&rft.issn=01483919&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Water ER - TY - JOUR T1 - Stimulus timing device for capturing fast physiologic events by quick-freezing. AN - 16467082; 32395 AB - A timing device was designed that, in conjunction with an impact type of quick-freezing apparatus and an externally-triggerable stimulus generator, allows the application of an electrical stimulus to a muscle preparation at a selected time interval before quick-freezing and the measurement of the interval with submillisecond precision. This is needed for stopping fast physiological events in calcium release and excitation-contraction coupling and allows studying the morphological parameters (by freeze-fracture and freeze-substitution) and elemental distributions (by x-ray microanalysis) as a function of time after stimulation. The device should be adaptable for use with most equipment designed for quick-freezing electrically excitable tissue by impact on a cold solid surface. JF - Scanning Microscopy AU - Nassar, R AU - Sommer, J R AD - Duke Univ and Veterans Administration Medical Cent, Durham, NC, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 745 EP - 751 VL - 6 IS - 3 SN - 0891-7035, 0891-7035 KW - Biology KW - Cryogenics KW - Freeze fracture KW - Freeze substitution KW - Freezing KW - In vivo structure KW - Microanalysis KW - Microscopic examination KW - Morphology KW - Muscle KW - Physiological agents KW - Quick freezing KW - Timing devices KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Mechanical Engineering Abstracts (ISMEC) KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 741.1:LIGHT/OPTICS KW - W4 461.9:BIOLOGY KW - W4 644.4:CRYOGENICS KW - W 30965:Miscellaneous, Reviews KW - W4 801.1:CHEMISTRY (GENERAL) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16467082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+Microscopy&rft.atitle=Stimulus+timing+device+for+capturing+fast+physiologic+events+by+quick-freezing.&rft.au=Nassar%2C+R%3BSommer%2C+J+R&rft.aulast=Nassar&rft.aufirst=R&rft.date=1992-01-01&rft.volume=6&rft.issue=3&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Scanning+Microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Morphology; Freezing; Cryogenics; Biology ER - TY - JOUR T1 - Mineral fiber content of lung tissue in patients with environmental exposures: household contacts vs. building occupants. AN - 72707809; 1809164 AB - Analysis of tissue mineral fiber content in patients with environmental exposures has seldom been reported in the past. Our studies of six household contacts of asbestos workers indicate that these individuals often have pulmonary asbestos concentrations similar to some occupationally exposed individuals. In contrast, our studies of four occupants of buildings with asbestos-containing materials indicate that these individuals often have pulmonary asbestos burdens indistinguishable from the general nonoccupationally exposed population. However, one such building occupant exposed for many years and who later developed pleural mesothelioma was studied in detail, and it was concluded that her exposure as a teacher's aide in a school building containing acoustical plaster was the likely cause of her mesothelioma. JF - Annals of the New York Academy of Sciences AU - Roggli, V L AU - Longo, W E AD - Department of Pathology, Durham Veterans Administration, North Carolina. Y1 - 1991/12/31/ PY - 1991 DA - 1991 Dec 31 SP - 511 EP - 518 VL - 643 SN - 0077-8923, 0077-8923 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Adult KW - Environmental Exposure KW - Family KW - Aged KW - Middle Aged KW - Male KW - Female KW - Air Pollution, Indoor -- adverse effects KW - Peritoneal Neoplasms -- etiology KW - Mesothelioma -- etiology KW - Pleural Neoplasms -- pathology KW - Peritoneal Neoplasms -- pathology KW - Mesothelioma -- pathology KW - Asbestos -- adverse effects KW - Pleural Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72707809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Mineral+fiber+content+of+lung+tissue+in+patients+with+environmental+exposures%3A+household+contacts+vs.+building+occupants.&rft.au=Roggli%2C+V+L%3BLongo%2C+W+E&rft.aulast=Roggli&rft.aufirst=V&rft.date=1991-12-31&rft.volume=643&rft.issue=&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-15 N1 - Date created - 1992-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis. AN - 72517497; 1744103 AB - We have recently shown that the immediately submembranous domain of the human insulin receptor (hIR) is required for rapid ligand-dependent internalization (Thies, R. S., Webster, N. J., and McClain, D. A. (1990) J. Biol. Chem. 265, 10132-10137). This region contains one copy of an NPXY sequence that is required for endocytosis of the low density lipoprotein receptor. In order to dissect and analyze the specific sequences involved in endocytosis of the insulin receptor, we have mutated the NPXY sequence from NPEY (residues 957-960) to APEA (NPEY/APEA). In addition, we have mutated a similar sequence in the same region, changing GPLY (residues 950-953) to APLA (GPLY/APLA). The cDNAs encoding the normal hIR and these mutant receptors were transfected into Rat 1 fibroblasts. The expressed receptors bound insulin with high affinity and retained insulin-stimulated tyrosine kinase activity. Despite the ability of these mutant receptors to bind insulin and undergo autophosphorylation, the GPLY/APLA receptor internalized insulin at only 32% of the rate of normal hIR at low receptor occupancy. On the other hand, the NPEY/APEA receptor internalized insulin at 87% of the normal rate. These results were confirmed by measuring internalization of photoaffinity-labeled insulin receptors. Another receptor with both the NPEY/APEA and GPLY/APLA mutations internalized to a lesser degree than the GPLY/APLA receptor and at a rate equivalent to that seen for a receptor with the entire submembranous domain deleted. A receptor with the complete normal submembranous domain but with the tyrosine kinase and C-terminal region of the hIR deleted exhibited only a basal internalization rate. We conclude that the information contained in the GPLY and, to a lesser extent, the NPEY sequences are necessary but not sufficient for signaling internalization of the insulin receptor. JF - The Journal of biological chemistry AU - Rajagopalan, M AU - Neidigh, J L AU - McClain, D A AD - Veterans Administration Medical Center, Birmingham, Alabama. Y1 - 1991/12/05/ PY - 1991 DA - 1991 Dec 05 SP - 23068 EP - 23073 VL - 266 IS - 34 SN - 0021-9258, 0021-9258 KW - DNA KW - 9007-49-2 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, Insulin KW - Index Medicus KW - Swine KW - Animals KW - Humans KW - Amino Acid Sequence KW - Protein-Tyrosine Kinases -- metabolism KW - Cloning, Molecular KW - Rats KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Phosphorylation KW - Transfection KW - Kinetics KW - Molecular Sequence Data KW - Cell Line KW - Receptor, Insulin -- chemistry KW - Endocytosis KW - Receptor, Insulin -- genetics KW - Receptor, Insulin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72517497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Amino+acid+sequences+Gly-Pro-Leu-Tyr+and+Asn-Pro-Glu-Tyr+in+the+submembranous+domain+of+the+insulin+receptor+are+required+for+normal+endocytosis.&rft.au=Rajagopalan%2C+M%3BNeidigh%2C+J+L%3BMcClain%2C+D+A&rft.aulast=Rajagopalan&rft.aufirst=M&rft.date=1991-12-05&rft.volume=266&rft.issue=34&rft.spage=23068&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-13 N1 - Date created - 1992-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pancreatic enlargement in alcoholic pancreatitis: prevalence and natural history. AN - 85203324; pmid-1722232 AB - We determined the prevalence and natural history of pancreatic enlargement by abdominal ultrasonography or computed tomography in 72 patients with alcoholic pancreatitis. Pancreatic enlargement was observed in 54 patients (75%); it was diffuse in 28 (52%) and focal in 26 (48%). The focal enlargement was frequently cystic (50%), while the diffuse enlargement was only occasionally cystic (7%). Sequential imaging of the pancreas in 29 patients demonstrated partial to total resolution of pancreatic enlargement in greater than 50% during 6 months of follow-up. Determination of serum amylase and p-isoamylase activity was neither sensitive nor specific for pancreatic enlargement in alcoholic pancreatitis. JF - Journal of Clinical Gastroenterology AU - Friedman, A D AU - Dutta, S K AU - Dubin, E H AU - Medhat, A AU - Keramati, B AU - Whitley, N AD - Department of Medicine, Veterans Administration Medical Center, University of Maryland School of Medicine, Baltimore. PY - 1991 SP - 666 EP - 672 VL - 13 IS - 6 SN - 0192-0790, 0192-0790 KW - Acute Disease KW - Human KW - Pancreas KW - Amylases KW - Tomography, X-Ray Computed KW - Aged KW - Hypertrophy KW - Prospective Studies KW - Isoamylase KW - Aged, 80 and over KW - Adult KW - Alcoholism KW - Middle Age KW - Male KW - Female KW - Pancreatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85203324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Pancreatic+enlargement+in+alcoholic+pancreatitis%3A+prevalence+and+natural+history.&rft.au=Friedman%2C+A+D%3BDutta%2C+S+K%3BDubin%2C+E+H%3BMedhat%2C+A%3BKeramati%2C+B%3BWhitley%2C+N&rft.aulast=Friedman&rft.aufirst=A&rft.date=1991-12-01&rft.volume=13&rft.issue=6&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The importance of hiatal hernia in reflux esophagitis compared with lower esophageal sphincter pressure or smoking. AN - 85203282; pmid-1761836 AB - The characteristics of gastroesophageal reflux disease have not been adequately defined. To determine the influence on the esophageal mucosa of hiatal hernia, lower esophageal sphincter pressure, acid reflux, and cigarettes and alcohol, we studied the reflux parameters, smoking habits, and alcohol consumption of 184 healthy, ambulatory outpatients who received endoscopy as the initial diagnostic procedure for workup of gastroesophageal reflux. Patients received endoscopic and histologic evaluations of the esophageal mucosa, prolonged ambulatory esophageal pH monitoring, and esophageal manometric determinations. Structural analysis was used to test the plausibility of various clinical theories concerning the most important factors contributing to the development of esophagitis. Statistical analyses revealed the following: (a) the lower esophageal sphincter pressure, acid contact time, and frequency of reflux episodes were highly associated with the presence of a hiatal hernia (p less than 0.003 for all parameters); (b) individuals with esophagitis had 16.5 times as many hiatal hernias as found in normal, healthy people; (c) cigarette smoking was not correlated with esophagitis but was significantly associated with increased lower esophageal sphincter pressure (r = 0.18; p less than 0.03); and (d) smoking was also not associated with increased acid contact time or increased frequency of reflux episodes. We conclude that (a) the presence of a hiatal hernia, not the pressure of the lower esophageal sphincter, is the most important predictor of reflux frequency, acid contact time, and esophagitis; (b) a decreased lower esophageal sphincter pressure, as suggested by structural analysis, is unlikely to be the cause of increased reflux episodes or esophagitis; and (c) if smoking and lower esophageal sphincter pressure are factors in the development of esophagitis, they damage the esophageal mucosa by mechanisms other than increased frequency of reflux episodes or increased acid contact time. JF - Journal of Clinical Gastroenterology AU - Sontag, S J AU - Schnell, T G AU - Miller, T Q AU - Nemchausky, B AU - Serlovsky, R AU - O'Connell, S AU - Chejfec, G AU - Seidel, U J AU - Brand, L AD - Department of Ambulatory, Veterans Administration Hospital, Hines, Illinois 60141. PY - 1991 SP - 628 EP - 643 VL - 13 IS - 6 SN - 0192-0790, 0192-0790 KW - Hernia, Hiatal KW - Smoking KW - Esophagitis, Peptic KW - Comparative Study KW - Computer Simulation KW - Models, Structural KW - Human KW - Esophagogastric Junction KW - Manometry KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85203282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=The+importance+of+hiatal+hernia+in+reflux+esophagitis+compared+with+lower+esophageal+sphincter+pressure+or+smoking.&rft.au=Sontag%2C+S+J%3BSchnell%2C+T+G%3BMiller%2C+T+Q%3BNemchausky%2C+B%3BSerlovsky%2C+R%3BO%27Connell%2C+S%3BChejfec%2C+G%3BSeidel%2C+U+J%3BBrand%2C+L&rft.aulast=Sontag&rft.aufirst=S&rft.date=1991-12-01&rft.volume=13&rft.issue=6&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Eye injury in a podiatrist. AN - 72700333; 1804955 JF - Journal of the American Podiatric Medical Association AU - Davis, J M AU - Kugler, G AU - Nixon, B P AD - Tucson Veterans Administration Medical Center, Tucson, AZ. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 661 EP - 663 VL - 81 IS - 12 SN - 8750-7315, 8750-7315 KW - Index Medicus KW - Eye Protective Devices KW - Humans KW - Eye Injuries, Penetrating -- etiology KW - Podiatry KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Eye Injuries, Penetrating -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72700333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Eye+injury+in+a+podiatrist.&rft.au=Davis%2C+J+M%3BKugler%2C+G%3BNixon%2C+B+P&rft.aulast=Davis&rft.aufirst=J&rft.date=1991-12-01&rft.volume=81&rft.issue=12&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-05 N1 - Date created - 1992-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lithium carbonate and mood disorder in recently detoxified alcoholics: a double-blind, placebo-controlled pilot study. AN - 72667982; 1789394 AB - The effects of lithium carbonate were assessed in a double-blind, placebo-controlled study of a small group of recently detoxified alcoholics. The patients were treated during their 2nd and 3rd week of abstinence. A previous study demonstrated the existence in these patients of a syndrome of mildly elevated psychomotor rate, including irritability, grandiosity, an increased need for social contact, loquaciousness, and sexual preoccupation. The intensity of this syndrome was significantly decreased by treatment with low dose lithium carbonate, with no effect of placebo treatment. JF - Alcoholism, clinical and experimental research AU - Nagel, K AU - Adler, L E AU - Bell, J AU - Nagamoto, H T AU - Freedman, R AD - Department of Psychiatry, Denver Veterans Administration Medical Center, University of Colorado Health Sciences Center 80262. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 978 EP - 981 VL - 15 IS - 6 SN - 0145-6008, 0145-6008 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Ethanol -- adverse effects KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Double-Blind Method KW - Personality Inventory -- statistics & numerical data KW - Humans KW - Adult KW - Alcohol Withdrawal Delirium -- psychology KW - Pilot Projects KW - Middle Aged KW - Temperance KW - Psychometrics KW - Male KW - Lithium Carbonate -- therapeutic use KW - Alcoholism -- rehabilitation KW - Bipolar Disorder -- rehabilitation KW - Bipolar Disorder -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72667982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Lithium+carbonate+and+mood+disorder+in+recently+detoxified+alcoholics%3A+a+double-blind%2C+placebo-controlled+pilot+study.&rft.au=Nagel%2C+K%3BAdler%2C+L+E%3BBell%2C+J%3BNagamoto%2C+H+T%3BFreedman%2C+R&rft.aulast=Nagel&rft.aufirst=K&rft.date=1991-12-01&rft.volume=15&rft.issue=6&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-20 N1 - Date created - 1992-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dynorphins other than dynorphin A(1-17) lack spinal antianalgesic activity but do act on dynorphin A(1-17) receptors. AN - 72582030; 1684812 AB - In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t.) were shown not to have antianalgesic activity even at high doses (0.5-1 pmol). These Dyns, i.t., did not antagonize the antinociception produced by physostigmine administered i.c.v. or morphine given i.t. These Dyns lacked the intrinsic antianalgesic activity of Dyn A(1-17). However, they had affinity for Dyn A(1-17) receptors as shown in several ways. 1) The antagonism of physostigmine antinociception produced by Dyn A(1-17) given i.t. was reversed by these Dyns given together with Dyn A(1-17). 2) The effect of endogenously released Dyn A(1-17) was reversed. Administered i.c.v., clonidine simultaneously activates antinociceptive and antianalgesic systems [latter mediated spinally by Dyn A(1-17) release]. Thus, these Dyns given i.t. inhibited the action of endogenously released Dyn A(1-17) and allowed the full manifestation of the antinociceptive action of clonidine.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Rady, J J AU - Fujimoto, J M AU - Tseng, L F AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1073 EP - 1080 VL - 259 IS - 3 SN - 0022-3565, 0022-3565 KW - Peptide Fragments KW - 0 KW - Receptors, Opioid KW - dynorphin receptor KW - dynorphin (1-13) KW - 72957-38-1 KW - Dynorphins KW - 74913-18-1 KW - Morphine KW - 76I7G6D29C KW - Physostigmine KW - 9U1VM840SP KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Drug Interactions KW - Physostigmine -- pharmacology KW - Injections, Spinal KW - Peptide Fragments -- pharmacology KW - Mice KW - Male KW - Nociceptors -- drug effects KW - Morphine -- pharmacology KW - Dynorphins -- antagonists & inhibitors KW - Receptors, Opioid -- drug effects KW - Spinal Cord -- secretion KW - Spinal Cord -- drug effects KW - Dynorphins -- secretion KW - Dynorphins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72582030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Dynorphins+other+than+dynorphin+A%281-17%29+lack+spinal+antianalgesic+activity+but+do+act+on+dynorphin+A%281-17%29+receptors.&rft.au=Rady%2C+J+J%3BFujimoto%2C+J+M%3BTseng%2C+L+F&rft.aulast=Rady&rft.aufirst=J&rft.date=1991-12-01&rft.volume=259&rft.issue=3&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-07 N1 - Date created - 1992-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential effects of diabetes on adipocyte and liver phosphotyrosine and phosphoserine phosphatase activities. AN - 72576052; 1661692 AB - We examined the activities of particulate and cytosolic phosphotyrosine phosphatase (PTPase) and phosphoserine phosphatase (PSPase) in adipocytes and livers of diabetic rats. PTPase activity was assessed with [32P]tyrosine-phosphorylated insulin receptor (IR), whereas PSPase activity was assayed with [32P]serine-phosphorylated glycogen synthase. Diabetes increased adipocyte particulate PTPase activity and enhanced IR dephosphorylation by 75% on the 2nd, 93% on the 14th, and 108% on the 30th day. In contrast, cytosolic PTPase activity decreased by 78% on the 14th and 45% on the 30th day (no change on the 2nd day). Similar changes were observed with PSPase (increased activity in particulate and decreased in cytosolic). Insulin therapy for 14 or 30 days restored PTPase and PSPase activities in both fractions. Vanadate, despite rapid normalization of glycemia, restored these activities only after 30 days of therapy. Diabetes-related changes in liver PTPase activity were observed on the 14th day only. At this time, it was increased in both particulate and cytosolic fractions. There was spontaneous normalization of the liver PTPase activity at 30 days of diabetes. In contrast, liver cytosolic PSPase activity was significantly inhibited and not normalized by the 30th day of disease without therapy. In summary, diabetes appears to induce tissue-specific changes in PTPase and PSPase activities resulting in significant alterations in dephosphorylation of IR and glycogen synthase. Moreover, there appears to be a differential regulation of PTPase and PSPase activities in diabetes, particularly in the liver. JF - Diabetes AU - Begum, N AU - Sussman, K E AU - Draznin, B AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1620 EP - 1629 VL - 40 IS - 12 SN - 0012-1797, 0012-1797 KW - Ethers, Cyclic KW - 0 KW - Insulin KW - Macromolecular Substances KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Vanadates KW - 3WHH0066W5 KW - Glycogen Synthase KW - EC 2.4.1.11 KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - phosphoserine phosphatase KW - EC 3.1.3.3 KW - Protein Tyrosine Phosphatases KW - EC 3.1.3.48 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Reference Values KW - Vanadates -- pharmacology KW - Cytosol -- enzymology KW - Insulin -- therapeutic use KW - Ethers, Cyclic -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Glycogen Synthase -- metabolism KW - Kinetics KW - Male KW - Receptor, Insulin -- metabolism KW - Liver -- enzymology KW - Diabetes Mellitus, Experimental -- drug therapy KW - Protein Tyrosine Phosphatases -- metabolism KW - Liver -- drug effects KW - Adipose Tissue -- drug effects KW - Diabetes Mellitus, Experimental -- enzymology KW - Adipose Tissue -- enzymology KW - Phosphoric Monoester Hydrolases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72576052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Differential+effects+of+diabetes+on+adipocyte+and+liver+phosphotyrosine+and+phosphoserine+phosphatase+activities.&rft.au=Begum%2C+N%3BSussman%2C+K+E%3BDraznin%2C+B&rft.aulast=Begum&rft.aufirst=N&rft.date=1991-12-01&rft.volume=40&rft.issue=12&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-03 N1 - Date created - 1992-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Temafloxacin compared with ciprofloxacin in mild to moderate lower respiratory tract infections in ambulatory patients. A multicenter, double-blind, randomized study. AN - 72505474; 1659975 AB - The efficacy and safety of oral temafloxacin (600 mg) and ciprofloxacin (500 mg) twice daily for seven days were compared in patients with mild to moderate lower respiratory tract infections. Fifty-eight of 64 (91 percent) patients who received temafloxacin and 63 of 67 (94 percent) patients who received ciprofloxacin had clinical cure or improvement; bacteriologic cure occurred in 61 (95 percent) and 63 (94 percent), respectively. All 14 patients with pneumonia were clinically cured or improved and bacteriologically cured; 11 had complete resolution of roentgenographic evidence of pneumonia. Both quinolones eradicated most major respiratory pathogens. In the ciprofloxacin group, organisms persisted in three of seven Pseudomonas aeruginosa isolates and in one of eight Hemophilus parainfluenzae isolates; all these pathogens were eliminated with temafloxacin. Theophylline blood levels significantly increased by 25 percent in the ciprofloxacin group and decreased by 5 percent in the temafloxacin group. Adverse events, mostly dizziness, headache, and gastrointestinal effects, occurred in 43 percent of temafloxacin patients and in 31 percent of ciprofloxacin patients. JF - Chest AU - Chodosh, S AD - Veterans Administration Outpatient Clinic, Boston 02114. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1497 EP - 1502 VL - 100 IS - 6 SN - 0012-3692, 0012-3692 KW - Anti-Infective Agents KW - 0 KW - Fluoroquinolones KW - Quinolones KW - temafloxacin KW - 1WZ12GTT67 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Abridged Index Medicus KW - Index Medicus KW - Pneumonia -- microbiology KW - Double-Blind Method KW - Humans KW - Middle Aged KW - Pneumonia -- drug therapy KW - Microbial Sensitivity Tests KW - Lung Diseases, Obstructive -- complications KW - Male KW - Female KW - Ambulatory Care KW - Quinolones -- adverse effects KW - Anti-Infective Agents -- therapeutic use KW - Respiratory Tract Infections -- microbiology KW - Anti-Infective Agents -- adverse effects KW - Quinolones -- therapeutic use KW - Ciprofloxacin -- therapeutic use KW - Ciprofloxacin -- adverse effects KW - Respiratory Tract Infections -- drug therapy KW - Respiratory Tract Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Temafloxacin+compared+with+ciprofloxacin+in+mild+to+moderate+lower+respiratory+tract+infections+in+ambulatory+patients.+A+multicenter%2C+double-blind%2C+randomized+study.&rft.au=Chodosh%2C+S&rft.aulast=Chodosh&rft.aufirst=S&rft.date=1991-12-01&rft.volume=100&rft.issue=6&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-08 N1 - Date created - 1992-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The antiinflammatory effect of dopamine in alcoholic hemorrhagic pancreatitis in cats. Studies on the receptors and mechanisms of action. AN - 72491945; 1659548 AB - Hemorrhagic pancreatitis was induced in cats by perfusing pancreatic enzymes through a pancreatic duct after the administration of intragastric ethanol. Dimethyl prostaglandin E2 was administered concurrently. In the first study, dopamine's antiinflammatory effect on the pancreas was determined in the presence of haloperidol, propranolol, or both. Next, dopamine's effects on blood flow in the normal and inflamed pancreas were compared using a hydrogen gas-clearance technique. In the final study, the effect of dopamine on fluorescein isothiocyanate-labeled dextran leakage from the pancreatic duct to portal venous blood was investigated. It was found that blockade of either dopamine or beta-adrenergic receptors reduced, and blockade of both receptors completely eliminated, the antiinflammatory effect. Dopamine had no effect on pancreatic blood flow in normal cats. In pancreatitis, although dopamine transiently reduced blood flow, after an hour flow had returned to normal. Dopamine reversed the leakage of fluorescein isothiocyanate-labeled dextran from the pancreatic duct caused by ethanol and by ethanol and prostaglandin E2. It was concluded that dopamine ameliorated pancreatitis by reducing pancreatic ductal and/or microvascular permeability rather than by altering pancreatic blood flow. The antiinflammatory effect was mediated by both dopamine and beta-adrenergic receptors. JF - Gastroenterology AU - Karanjia, N D AU - Widdison, A L AU - Lutrin, F J AU - Chang, Y B AU - Reber, H A AD - Department of Surgery, Veterans Administration Medical Center, Sepulveda, California. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1635 EP - 1641 VL - 101 IS - 6 SN - 0016-5085, 0016-5085 KW - Prostaglandins E KW - 0 KW - Receptors, Adrenergic, beta KW - Receptors, Dopamine KW - Ethanol KW - 3K9958V90M KW - Propranolol KW - 9Y8NXQ24VQ KW - Haloperidol KW - J6292F8L3D KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Acute Disease KW - Animals KW - Prostaglandins E -- pharmacology KW - Ethanol -- pharmacology KW - Receptors, Adrenergic, beta -- immunology KW - Propranolol -- pharmacology KW - Haloperidol -- pharmacology KW - Cats KW - Receptors, Dopamine -- immunology KW - Receptors, Adrenergic, beta -- drug effects KW - Pancreas -- pathology KW - Dopamine -- pharmacology KW - Capillary Permeability -- drug effects KW - Pancreas -- drug effects KW - Pancreatitis -- etiology KW - Hemorrhage -- etiology KW - Hemorrhage -- drug therapy KW - Pancreatitis -- pathology KW - Dopamine -- therapeutic use KW - Hemorrhage -- pathology KW - Pancreas -- blood supply KW - Alcoholism -- complications KW - Pancreatitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72491945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=The+antiinflammatory+effect+of+dopamine+in+alcoholic+hemorrhagic+pancreatitis+in+cats.+Studies+on+the+receptors+and+mechanisms+of+action.&rft.au=Karanjia%2C+N+D%3BWiddison%2C+A+L%3BLutrin%2C+F+J%3BChang%2C+Y+B%3BReber%2C+H+A&rft.aulast=Karanjia&rft.aufirst=N&rft.date=1991-12-01&rft.volume=101&rft.issue=6&rft.spage=1635&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-02 N1 - Date created - 1992-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Conjugal transfer of antibiotic resistance factors in Bacteroides fragilis: the btgA and btgB genes of plasmid pBFTM10 are required for its transfer from Bacteroides fragilis and for its mobilization by IncP beta plasmid R751 in Escherichia coli. AN - 72452977; 1657890 AB - Transferable plasmids play an important role in the dissemination of clindamycin-erythromycin resistance in Bacteroides fragilis. We previously described the isolation and properties of pBFTM10, a 14.9-kb ClnR transfer factor from B. fragilis TMP10. We also reported the isolation of a transfer-deficient deletion derivative of pBFTM10 contained in the B. fragilis-Escherichia coli shuttle vector pGAT400. In the present study we used pGAT400 and a similar shuttle vector, pGAT550, to characterize and sequence a region of pBFTM10 required for its transfer from B. fragilis to B. fragilis or E. coli recipients and for its mobilization by the broad-host-range plasmid R751 from E. coli donors to E. coli recipients. Deletion of certain BglII restriction fragments from pBFTM10 resulted in partial or complete loss of transfer ability. Tn1000 insertions into this same region also resulted in altered transfer properties. We used the sites of Tn1000 insertions to determine the DNA sequence of the transfer region. Two potential open reading frames encoding proteins of 23.2 and 33.8 kDa, corresponding to two genes, btgA or btgB, were identified in the sequence. Tn1000 insertions within btgA or btgB or deletion of all or portions of btgA or btgB resulted in either a transfer deficiency or greatly reduced transfer from B. fragilis donors and alterations in mobilization by R751 in E. coli. A potential oriT sequence showing similarity in organization to the oriT regions of the IncP plasmids was also detected. Thus, pBFTM10 encodes and requires at least two proteins necessary for efficient transfer from B. fragilis. These same functions are expressed in E. coli and are required for mobilization by R751. JF - Journal of bacteriology AU - Hecht, D W AU - Jagielo, T J AU - Malamy, M H AD - Department of Medicine, Veterans Administration Hospital-Hines, Illinois 60141. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 7471 EP - 7480 VL - 173 IS - 23 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - DNA Transposable Elements KW - DNA, Bacterial KW - BtgA protein, Bacteroides fragilis KW - 145715-60-2 KW - BtgB protein, Bacteroides fragilis KW - 145715-61-3 KW - Clindamycin KW - 3U02EL437C KW - Erythromycin KW - 63937KV33D KW - Index Medicus KW - Phenotype KW - Protein Biosynthesis KW - Chromosome Deletion KW - Base Sequence KW - Bacterial Proteins -- genetics KW - DNA, Bacterial -- genetics KW - Restriction Mapping KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Plasmids KW - Mutagenesis, Insertional KW - R Factors KW - Genes, Bacterial KW - Bacteroides fragilis -- drug effects KW - Drug Resistance, Microbial -- genetics KW - Conjugation, Genetic KW - Clindamycin -- pharmacology KW - Escherichia coli -- genetics KW - Bacteroides fragilis -- genetics KW - Erythromycin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72452977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Conjugal+transfer+of+antibiotic+resistance+factors+in+Bacteroides+fragilis%3A+the+btgA+and+btgB+genes+of+plasmid+pBFTM10+are+required+for+its+transfer+from+Bacteroides+fragilis+and+for+its+mobilization+by+IncP+beta+plasmid+R751+in+Escherichia+coli.&rft.au=Hecht%2C+D+W%3BJagielo%2C+T+J%3BMalamy%2C+M+H&rft.aulast=Hecht&rft.aufirst=D&rft.date=1991-12-01&rft.volume=173&rft.issue=23&rft.spage=7471&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-26 N1 - Date created - 1991-12-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M77806; GENBANK; M64329; S65502; M64328; M64332; M64331; M63255; S65448; M64330; S65603 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1991 Jun 25;19(12):3455 [1648208] J Bacteriol. 1980 Sep;143(3):1362-73 [6251029] J Bacteriol. 1989 Jul;171(7):4100-3 [2544570] J Bacteriol. 1989 Jul;171(7):3603-8 [2544548] J Bacteriol. 1985 Dec;164(3):1248-55 [2999075] J Bacteriol. 1987 Aug;169(8):3573-80 [3038844] Crit Rev Microbiol. 1987;14(1):49-71 [3030631] Plasmid. 1987 Mar;17(2):87-109 [3039558] Plasmid. 1988 Nov;20(3):259-65 [3072579] Proc Natl Acad Sci U S A. 1989 Mar;86(6):1771-5 [2538813] J Biol Chem. 1989 Jul 15;264(20):11989-94 [2663846] Antimicrob Agents Chemother. 1988 May;32(5):717-22 [3395102] Proc Natl Acad Sci U S A. 1984 Nov;81(22):7203-6 [6095273] J Bacteriol. 1986 Jun;166(3):959-65 [3519587] J Bacteriol. 1984 May;158(2):739-41 [6725207] Antimicrob Agents Chemother. 1983 May;23(5):726-30 [6870222] Antimicrob Agents Chemother. 1983 Apr;23(4):536-40 [6859833] J Antimicrob Chemother. 1981 Dec;8 Suppl D:59-75 [7040329] Antimicrob Agents Chemother. 1982 Oct;22(4):701-3 [7181480] J Infect Dis. 1979 Jan;139(1):97-101 [108340] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Plasmid. 1979 Apr;2(2):261-8 [451051] J Infect Dis. 1979 Jan;139(1):83-8 [438530] J Mol Biol. 1978 Dec 15;126(3):347-65 [745233] J Bacteriol. 1990 May;172(5):2584-93 [2110145] Annu Rev Biochem. 1990;59:933-69 [2197994] J Biol Chem. 1990 Jun 25;265(18):10637-44 [2191955] Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1456-60 [1996345] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risks of blood volume changes in hypogonadal men treated with testosterone enanthate for erectile impotence. AN - 72452440; 1942342 AB - Administration of anabolic steroids carries many risks. We present a series of 15 patients with primary hypogonadism who as a group had statistically significant increases in whole body hematocrit and red blood cell volume while on testosterone therapy of 300 mg. intramuscularly every 3 weeks. A small decrease in plasma volume over-all was not significant. Subsequent analyses compared subgroups whose whole body hematocrit during testosterone therapy was either 48% or greater (9) or less than 48% (6). Interaction effects indicated that the subgroups were similar when off testosterone but when on testosterone the former group exhibited an increase in red blood cell volume and a decrease in plasma volume, while the latter group had little change in either measurement. Subsequent to stopping testosterone therapy 2 patients in the whole body hematocrit 48% or greater group suffered strokes and 1 had transient ischemic attacks while on therapy. No one in the whole body hematocrit less than 48% group has had any cerebrovascular symptoms. Clinical implications, as well as cost-effective and practical suggestions for detecting possible dangerous hemoconcentration are discussed. JF - The Journal of urology AU - Krauss, D J AU - Taub, H A AU - Lantinga, L J AU - Dunsky, M H AU - Kelly, C M AD - Veterans Administration Medical Center, Syracuse, New York. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1566 EP - 1570 VL - 146 IS - 6 SN - 0022-5347, 0022-5347 KW - Testosterone KW - 3XMK78S47O KW - testosterone enanthate KW - 7Z6522T8N9 KW - Abridged Index Medicus KW - Index Medicus KW - Plasma Volume -- drug effects KW - Cerebrovascular Disorders -- chemically induced KW - Humans KW - Hematocrit KW - Aged KW - Middle Aged KW - Erythrocyte Volume -- drug effects KW - Male KW - Testosterone -- analogs & derivatives KW - Testosterone -- therapeutic use KW - Erectile Dysfunction -- drug therapy KW - Testosterone -- adverse effects KW - Erectile Dysfunction -- etiology KW - Blood Volume -- drug effects KW - Hypogonadism -- complications KW - Hypogonadism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72452440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Risks+of+blood+volume+changes+in+hypogonadal+men+treated+with+testosterone+enanthate+for+erectile+impotence.&rft.au=Krauss%2C+D+J%3BTaub%2C+H+A%3BLantinga%2C+L+J%3BDunsky%2C+M+H%3BKelly%2C+C+M&rft.aulast=Krauss&rft.aufirst=D&rft.date=1991-12-01&rft.volume=146&rft.issue=6&rft.spage=1566&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-23 N1 - Date created - 1991-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of Exercise Training on Multiple Respiratory Variables in Patients with Coronary Artery Disease: Correlation with Change in Exercise Capacity AN - 20078606; 10100796 AB - Multiple measurements of pulmonary function were performed during exer cise testing in 29 patients with coronary artery disease (CAD) before and after exercise training. Following training, significant increases in oxygen consump tion (VO sub( 2)), carbon dioxide production (VCO sub(2)), and peak flow at maximal exer cise were seen as compared with pretraining values (p < .01), but not in any other respiratory variables. Only the peak respiratory exchange ratio (RER) achieved during pretraining exercise testing and peak values of minute ventilation (V sub(T)), respiratory rate, and VCO sub(2) during a posttraining exercise test showed signifi cant correlations with the change in maximum VO sub(2) following exercise training (p<.05). Significant correlations were also found among V sub(T), VCO sub(2), and peak flow at peak exercise following exercise training and the change in exercise du ration between pretraining and posttraining stress tests. Of 22 patients evaluat ed with thallium 201 scintigraphy during their pretraining exercise test, 11 developed ischemic ST depression or a reversible perfusion defect. No signifi cant differences in pulmonary function measurements during exercise testing were seen between patients who developed ischemia and those who did not. However, the change in peak metabolic equivalents (METS) achieved between pretraining and posttraining exercise was significantly greater in patients who developed ische mia (.836 plus or minus 1.003 versus .091 plus or minus .481, p<.05).These results indicate that exercise training in patients with CAD is not as sociated with significant changes in most measurements of pulmonary function and, with the exception of RER at peak exercise, pretraining measurements do no show a significant correlation with changes in exercise capacity. JF - Angiology AU - Stratmann, Henry AD - he Department of Cardiology, St. Louis Veterans Administration Medical Center and St. Louis University, St. Louis, Missouri Y1 - 1991/12// PY - 1991 DA - Dec 1991 SP - 948 EP - 956 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 42 IS - 12 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Measurement KW - Stress tests KW - Motor performance tests KW - Patients KW - Exercise KW - Exercise (effects) KW - Diseases KW - Exercise (programs) KW - Circulatory system KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Effect+of+Exercise+Training+on+Multiple+Respiratory+Variables+in+Patients+with+Coronary+Artery+Disease%3A+Correlation+with+Change+in+Exercise+Capacity&rft.au=Stratmann%2C+Henry&rft.aulast=Stratmann&rft.aufirst=Henry&rft.date=1991-12-01&rft.volume=42&rft.issue=12&rft.spage=948&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331979104201202 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Measurement; Stress tests; Motor performance tests; Patients; Diseases; Exercise (effects); Exercise; Exercise (programs); Circulatory system DO - http://dx.doi.org/10.1177/000331979104201202 ER - TY - JOUR T1 - Long-term enteral feeding: a retrospective comparison of delivery via percutaneous endoscopic gastrostomy and nasoenteric tubes. AN - 85228040; pmid-1951237 AB - The use of percutaneous endoscopic gastrostomy (PEG) tubes for enteral feeding is widespread, although their superiority to other feeding devices, such as nasoenteric tubes (NET), has not been substantiated. We retrospectively compared clinical outcomes in patients who received enteral feeding via PEG (n = 80) or NET (n = 29) from 1984 to 1988. Mean follow-up was 192 days in the PEG group and 141 days in the NET group. Changes in nutritional and performance status were similar in both groups. Aspiration pneumonia occurred within 14 days of tube placement in 6% and 24% (p = 0.01) of the PEG and NET patients, respectively. With the exception of tube replacement, cumulative rates of minor and major complications (including aspiration pneumonia) were similar in both groups during follow-up. None of the clinical variables that were assessed correlated with the development of aspiration pneumonia. Mortality was similar in both groups. These results suggest that, for long-term enteral feeding, PEG offers no substantial advantages over NET with respect to patient nutrition, performance, or survival. The reasons for the observed difference in short-term aspiration pneumonia rates are unknown, and must be investigated prospectively. JF - The American Journal of Gastroenterology AU - Fay, D E AU - Poplausky, M AU - Gruber, M AU - Lance, P AD - Department of Medicine, State University of New York School of Medicine and Biomedical Sciences, Veterans Administration Medical Center, Buffalo. PY - 1991 SP - 1604 EP - 1609 VL - 86 IS - 11 SN - 0002-9270, 0002-9270 KW - Gastroscopy KW - Analysis of Variance KW - Comparative Study KW - Human KW - Chi-Square Distribution KW - Retrospective Studies KW - Support, U.S. Gov't, Non-P.H.S. KW - Support, Non-U.S. Gov't KW - Aged KW - Time Factors KW - Male KW - Enteral Nutrition KW - Gastrostomy KW - Intubation, Gastrointestinal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85228040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Long-term+enteral+feeding%3A+a+retrospective+comparison+of+delivery+via+percutaneous+endoscopic+gastrostomy+and+nasoenteric+tubes.&rft.au=Fay%2C+D+E%3BPoplausky%2C+M%3BGruber%2C+M%3BLance%2C+P&rft.aulast=Fay&rft.aufirst=D&rft.date=1991-11-01&rft.volume=86&rft.issue=11&rft.spage=1604&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects. AN - 72695092; 1802900 AB - In this article we describe the immunocytochemical and electron microscopic findings in five patients with toxic epidermal necrolysis. They indicate the occurrence of necrotic keratinocytes with nuclear disintegration associated with apposed dendritic cells with the nuclear chromatin configuration of T lymphocytes. These findings, including the presence of blebbing of the keratinocytes and membrane defects associated with cytoplasmic processes from these apposed lymphoid cells, fit known electron microscopic criteria that suggest the involvement of T lymphocyte-mediated cytolysis of drug-altered target keratinocytes in toxic epidermal necrolysis. The effector cell appears to be a dendritic subset, with the phenotypic characteristics (CD3+, CD4-, CD8+, CD2+, DR+) of a T cell subset. There is some evidence that tumor necrosis factor alpha, secreted by activated macrophages, may play a role in necrolysis of the epidermis. The dramatic response of our patients to cyclophosphamide, which is known to inhibit cell-mediated cytotoxicity by inhibiting both the recognition and lethal hit stages, together with the rapid regrowth of the epidermis within 4 days to a week in patients who received adequate dosage of the drug, supports the preceding concepts. JF - Journal of the American Academy of Dermatology AU - Heng, M C AU - Allen, S G AD - Department of Medicine, University of California San Fernando Valley Internal Medicine Program, Veterans Administration Medical Center, Sepulveda 91343. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 778 EP - 786 VL - 25 IS - 5 Pt 1 SN - 0190-9622, 0190-9622 KW - Phenytoin KW - 6158TKW0C5 KW - Allopurinol KW - 63CZ7GJN5I KW - Ampicillin KW - 7C782967RD KW - Cyclophosphamide KW - 8N3DW7272P KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - Drug Therapy, Combination -- adverse effects KW - Basement Membrane -- ultrastructure KW - Chlorpropamide -- adverse effects KW - Infusions, Intravenous KW - Humans KW - Cell Membrane -- ultrastructure KW - Aged KW - Ampicillin -- adverse effects KW - Allopurinol -- adverse effects KW - Adult KW - Middle Aged KW - Microscopy, Electron KW - Keratinocytes -- pathology KW - Epidermis -- pathology KW - Phenytoin -- adverse effects KW - T-Lymphocyte Subsets -- pathology KW - Immunohistochemistry KW - Male KW - Cyclophosphamide -- administration & dosage KW - Cyclophosphamide -- therapeutic use KW - Stevens-Johnson Syndrome -- pathology KW - Stevens-Johnson Syndrome -- etiology KW - Stevens-Johnson Syndrome -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72695092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Efficacy+of+cyclophosphamide+in+toxic+epidermal+necrolysis.+Clinical+and+pathophysiologic+aspects.&rft.au=Heng%2C+M+C%3BAllen%2C+S+G&rft.aulast=Heng&rft.aufirst=M&rft.date=1991-11-01&rft.volume=25&rft.issue=5+Pt+1&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-30 N1 - Date created - 1992-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Acad Dermatol. 1993 Mar;28(3):511 [8445077] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metronidazole-induced acute pancreatitis. AN - 72619103; 1775854 AB - Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found. JF - Reviews of infectious diseases AU - Corey, W A AU - Doebbeling, B N AU - DeJong, K J AU - Britigan, B E AD - Department of Internal Medicine and Research Service, Veterans Administration Medical Center, Iowa City, Iowa. PY - 1991 SP - 1213 EP - 1215 VL - 13 IS - 6 SN - 0162-0886, 0162-0886 KW - Metronidazole KW - 140QMO216E KW - Index Medicus KW - Acute Disease KW - Risk Factors KW - Humans KW - Middle Aged KW - Female KW - Rectovaginal Fistula -- drug therapy KW - Metronidazole -- therapeutic use KW - Crohn Disease -- drug therapy KW - Metronidazole -- adverse effects KW - Rectovaginal Fistula -- complications KW - Pancreatitis -- chemically induced KW - Crohn Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72619103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Metronidazole-induced+acute+pancreatitis.&rft.au=Corey%2C+W+A%3BDoebbeling%2C+B+N%3BDeJong%2C+K+J%3BBritigan%2C+B+E&rft.aulast=Corey&rft.aufirst=W&rft.date=1991-11-01&rft.volume=13&rft.issue=6&rft.spage=1213&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 1992 Oct;15(4):750-1 [1384729] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arm abscesses caused by Clostridium botulinum. AN - 72616479; 1774288 AB - Wound botulism is an uncommon disorder that continues to be rarely reported in the United States. A 34-year-old intravenous heroin user was admitted to the Loma Linda, Calif., Veterans Administration hospital with multiple abscesses on his forearms. His clinical course was compatible with botulism, and his culture and serum were positive for Clostridium botulinum toxin type A. Early culture and/or serum identification can lead to prompt diagnosis, treatment, and improvement in the morbidity and mortality rates of this disease. JF - Journal of clinical microbiology AU - Elston, H R AU - Wang, M AU - Loo, L K AD - Clinical Microbiology Laboratory, Veterans Administration Hospital, Loma Linda, California 92357. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2678 EP - 2679 VL - 29 IS - 11 SN - 0095-1137, 0095-1137 KW - Index Medicus KW - Humans KW - Adult KW - Arm KW - Male KW - Substance Abuse, Intravenous KW - Clostridium botulinum -- pathogenicity KW - Botulism -- diagnosis KW - Wound Infection -- diagnosis KW - Botulism -- etiology KW - Clostridium botulinum -- isolation & purification KW - Wound Infection -- etiology KW - Abscess -- etiology KW - Abscess -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72616479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Arm+abscesses+caused+by+Clostridium+botulinum.&rft.au=Elston%2C+H+R%3BWang%2C+M%3BLoo%2C+L+K&rft.aulast=Elston&rft.aufirst=H&rft.date=1991-11-01&rft.volume=29&rft.issue=11&rft.spage=2678&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1985 May;102(5):616-8 [3985512] West J Med. 1987 Sep;147(3):335-8 [3314158] J Clin Microbiol. 1986 Mar;23(3):616-8 [3514662] JAMA. 1974 Sep 2;229(10):1305-8 [4604287] Am J Med. 1984 May;76(5):794-8 [6720725] J Trauma. 1981 Jan;21(1):68-71 [7463544] N Engl J Med. 1973 Nov 8;289(19):1005-10 [4582478] Am J Epidemiol. 1986 Nov;124(5):794-9 [3766512] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aspirin dose-dependently reduces alcohol-induced birth defects and prostaglandin E levels in mice. AN - 72612596; 1771594 AB - The purpose of the present study was threefold. The first purpose was to determine if aspirin (ASA) decreases alcohol-induced birth defects in mice in a dose-dependent fashion. The second purpose was to see if the antagonism of alcohol-induced birth defects afforded by ASA pretreatment was related to dose-dependent decreases in prostaglandin E (PGE) levels in uterine/embryo tissue. The third purpose was to determine if ASA pretreatment altered maternal blood alcohol level. In experiments 1 and 2, pregnant C57BL/6J mice were administered ASA (0, 18.75, 37.5, 75, 150, or 300 mg/kg) on gestation day 10. One hour following the subcutaneous injection of ASA, mice received alcohol (5.8 g/kg) or an isocaloric sucrose solution intragastrically. In experiment 1 the incidence of birth defects was assessed in fetuses delivered by caesarean section on gestation day 19. In experiment 2 uterine/embryo tissue samples were collected on gestation day 10 1 hr following alcohol intubation for subsequent PGE analysis. In experiment 3 blood samples were taken at five time points following alcohol intubation from separate groups of alcohol-treated pregnant mice pretreated with 150 mg/kg ASA or vehicle. The results from the three experiments indicated that 1) ASA dose-dependently reduced the frequency of alcohol-induced birth defects in fetuses examined at gestation day 19, (2) ASA decreased the levels of PGE in gestation day 10 uterine/embryo tissue in a similar dose-dependent fashion, and 3) ASA pretreatment did not significantly influence maternal blood alcohol levels. These results provide additional support for the hypothesis that PGs may play an important role in mediating the teratogenic actions of alcohol. JF - Teratology AU - Randall, C L AU - Anton, R F AU - Becker, H C AU - Hale, R L AU - Ekblad, U AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 521 EP - 529 VL - 44 IS - 5 SN - 0040-3709, 0040-3709 KW - Prostaglandins E KW - 0 KW - Ethanol KW - 3K9958V90M KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Fetal Death -- chemically induced KW - Female KW - Pregnancy KW - Ethanol -- blood KW - Fetus -- drug effects KW - Prostaglandins E -- blood KW - Prostaglandins E -- antagonists & inhibitors KW - Ethanol -- antagonists & inhibitors KW - Prostaglandins E -- analysis KW - Ethanol -- toxicity KW - Fetus -- chemistry KW - Aspirin -- pharmacology KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72612596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Aspirin+dose-dependently+reduces+alcohol-induced+birth+defects+and+prostaglandin+E+levels+in+mice.&rft.au=Randall%2C+C+L%3BAnton%2C+R+F%3BBecker%2C+H+C%3BHale%2C+R+L%3BEkblad%2C+U&rft.aulast=Randall&rft.aufirst=C&rft.date=1991-11-01&rft.volume=44&rft.issue=5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-27 N1 - Date created - 1992-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma. AN - 72587306; 1761775 AB - Both topical nitrogen mustard and psoralen photochemotherapy may induce benign and malignant alterations in the skin. We describe the explosive appearance of multiple epidermal cysts and squamous cell carcinomas in a patient whose cutaneous T-cell lymphoma was treated sequentially with these two types of therapy. This is the first report of both processes in the same patient with cutaneous T-cell lymphoma. It strongly supports the concept of lesion induction, while raising the question of an additive or even synergistic effect of these types of therapy. JF - Journal of the American Academy of Dermatology AU - Smith, S P AU - Konnikov, N AD - Department of Dermatology, Boston Veterans Administration Medical Center, MA 02130. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 940 EP - 943 VL - 25 IS - 5 Pt 2 SN - 0190-9622, 0190-9622 KW - Mechlorethamine KW - 50D9XSG0VR KW - Index Medicus KW - PUVA Therapy -- adverse effects KW - Administration, Cutaneous KW - Humans KW - Middle Aged KW - Male KW - Skin Neoplasms -- drug therapy KW - Epidermal Cyst -- chemically induced KW - Carcinoma, Squamous Cell -- pathology KW - Skin Neoplasms -- chemically induced KW - Epidermal Cyst -- pathology KW - Carcinoma, Squamous Cell -- chemically induced KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Mechlorethamine -- adverse effects KW - Lymphoma, T-Cell, Cutaneous -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72587306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Eruptive+epidermal+cysts+and+multiple+squamous+cell+carcinomas+after+therapy+for+cutaneous+T-cell+lymphoma.&rft.au=Smith%2C+S+P%3BKonnikov%2C+N&rft.aulast=Smith&rft.aufirst=S&rft.date=1991-11-01&rft.volume=25&rft.issue=5+Pt+2&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-11 N1 - Date created - 1992-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Acad Dermatol. 1992 Oct;27(4):651-2 [1401332] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Possible pathogenetic role of low-molecular-weight proteins in Balkan nephropathy. AN - 72570144; 1762343 AB - Balkan endemic nephropathy (BEN) is a tubulointerstitial disease characterized by increased-low-molecular-weight protein (LMWP), most notably, beta 2-microglobulin (beta 2m) excretion in urine. We previously demonstrated that two species of LMWPs, immunoglobulin light chains (LC) and recombinant alpha interferon (rIF), are toxic at proximal tubule cell membrane level. Myeloma LCs and rIF inhibit Na-dependent uptake of 14C-L-alanine and 14C-D-glucose by rat renal brush border membrane (BBM) vesicles at half-maximal inhibitory concentrations, IC50, ranging from 68 to 140 microM for LCs, and 5.4 to 18 nM for rIF. We further demonstrated that LCs bind to high-capacity, low-affinity sites on BBM with dissociation constants (Kd) ranging from 16 to 118 microM, a range similar to IC50s observed with the same LCs. Binding site occupancy is inversely related to alanine (r = -0.95, P less than 0.01), and glucose uptake (r = -0.96, P less than 0.01), implying that LC nephrotoxicity is determined by its binding to BBM. beta 2m shares behavioral and structural similarities with both LC and rIF. Preliminary studies in our laboratory showed that unlabeled LCs compete for the same binding sites on BBM with beta 2m. These observations confirm that all LMWP, including beta 2m, are potentially nephrotoxic. Thus, the characteristic beta 2-microglobulinuria of BEN may be more than a consequence of tubular dysfunction, and may play a pathogenetic role. JF - Kidney international. Supplement AU - Batuman, V AD - Renal Section, Veterans Administration Medical Center, East Orange, New Jersey. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - S89 EP - S92 VL - 34 SN - 0098-6577, 0098-6577 KW - Interferon Type I KW - 0 KW - Myeloma Proteins KW - Recombinant Proteins KW - beta 2-Microglobulin KW - Index Medicus KW - Animals KW - beta 2-Microglobulin -- metabolism KW - Humans KW - Microvilli -- metabolism KW - Interferon Type I -- metabolism KW - Myeloma Proteins -- metabolism KW - Kidney Cortex -- metabolism KW - Protein Binding KW - Molecular Weight KW - Rats KW - Kinetics KW - In Vitro Techniques KW - Balkan Nephropathy -- etiology KW - Balkan Nephropathy -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72570144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international.+Supplement&rft.atitle=Possible+pathogenetic+role+of+low-molecular-weight+proteins+in+Balkan+nephropathy.&rft.au=Batuman%2C+V&rft.aulast=Batuman&rft.aufirst=V&rft.date=1991-11-01&rft.volume=34&rft.issue=&rft.spage=S89&rft.isbn=&rft.btitle=&rft.title=Kidney+international.+Supplement&rft.issn=00986577&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of complement 5a receptor expression in U937 cells by phorbol ester. AN - 72567572; 1660914 AB - Receptors for the anaphylactic portion of complement, C5a, are not initially expressed in the monoblastic U937 cell line, but appear as the cell is induced to differentiate by the synergistic actions of 1,25(OH)2D and cyclic adenosine monophosphate (cAMP). Phorbol myristate acetate (PMA), which activates the protein kinase C pathway (PKC), does not cause C5a receptor (C5aR) expression when used as a single agent. The induction of C5aR by the synergistic actions of 1,25(OH)2D and cAMP, however, can be augmented as much as 180% by the addition of PMA. C5aR arising in cells exposed to 1,25(OH)2D and 8,4-chlorophenylthio-cAMP have an affinity constant of about 0.4 nM as assessed by cold competition analysis. We show here that when phorbol augmentation of receptor number occurs, the affinity constant is increased by 3.6-fold. In an effort to ascertain whether the change in C5aR Kd involved a PKC-dependent event we examined whether 5-60 min exposure of C5aR-positive cells to PMA would change C5aR Kd. Acutely, PMA caused a downregulation of receptor binding with decreases in apparent receptor number out of proportion to changes in Kd. One hundred nanomolar PMA, which effects nearly complete translocation of PKC to the membrane, consistently caused a 70-90% decrease in C5a surface binding. This downregulation was proportional to PMA dose and exposure time. Micromolar concentrations of the microtubule depolymerizing agents colchicine and vinblastine caused a less drastic downregulation, about 50% of the maximal phorbol effect. Our data suggest that activation of the PKC system might acutely limit the macrophage's ability to respond to C5a; chronically, phorbols upregulate receptor expression, most likely through positive effects on C5aR gene expression. JF - Journal of leukocyte biology AU - Rubin, J AU - Titus, L AU - Nanes, M S AD - Veterans Administration Medical Center, Atlanta, Decatur, GA 30033. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 502 EP - 508 VL - 50 IS - 5 SN - 0741-5400, 0741-5400 KW - Receptor, Anaphylatoxin C5a KW - 0 KW - Receptors, Complement KW - Vinblastine KW - 5V9KLZ54CY KW - Complement C5a KW - 80295-54-1 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Vinblastine -- pharmacology KW - Complement C5a -- metabolism KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- ultrastructure KW - Humans KW - Enzyme Activation -- physiology KW - Calcitriol -- pharmacology KW - Colchicine -- pharmacology KW - Protein Binding -- drug effects KW - Up-Regulation -- drug effects KW - Cyclic AMP -- pharmacology KW - Tumor Cells, Cultured -- pathology KW - Protein Kinase C -- physiology KW - Drug Synergism KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Gene Expression Regulation, Leukemic -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Receptors, Complement -- genetics KW - Receptors, Complement -- physiology KW - Receptors, Complement -- metabolism KW - Lymphoma, Large B-Cell, Diffuse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72567572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Regulation+of+complement+5a+receptor+expression+in+U937+cells+by+phorbol+ester.&rft.au=Rubin%2C+J%3BTitus%2C+L%3BNanes%2C+M+S&rft.aulast=Rubin&rft.aufirst=J&rft.date=1991-11-01&rft.volume=50&rft.issue=5&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-23 N1 - Date created - 1992-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intracoronary C5a induces myocardial ischemia by mechanisms independent of the neutrophil: leukocyte filters desensitize the myocardium to C5a. AN - 72551930; 1661246 AB - Activation of the complement cascade with the generation of anaphylatoxins accompanies the inflammatory response elicited by acute myocardial ischemia and reperfusion. Although complement is activated in the interstitium during acute myocardial ischemia, we have studied mechanisms whereby complement might exacerbate ischemia by using a model employing intracoronary injection of C5a in nonischemic hearts. Intracoronary injection of complement component C5a induces transient myocardial ischemia, mediated through the production of the coronary vasoconstrictors thromboxane A2 and peptidoleukotrienes (LTC4, LTD4), and causes sequestration of polymorphonuclear leukocytes (PMN) in the coronary vascular bed. To further investigate the role of the PMN in the C5a-induced vasoconstriction, the left anterior descending coronary artery (LAD) in pigs was perfused at constant pressure and measurements of coronary blood flow, myocardial contractile function (sonomicrometry), arterial/coronary venous blood PMN count, and thromboxane B2 (TxB2) levels were performed. The myocardial response to intracoronary C5a (500 ng) was determined before, during, and after perfusion with blood depleted of PMNs using leukocyte filters (Sepacell R-500, Pall PL-100). In additional animals, the myocardial response to the PMN chemotactic agent, LTB4, and the effects of intracoronary C5a during constant flow perfusion were measured. Control intracoronary injection of C5a decreased flow (41% of baseline) and contractile function (39% of baseline), PMNs were trapped (5.1 x 10(3) cells/microliters), and TxB2 concentration increased in coronary venous blood. The response to C5a during coronary perfusion with arterial blood depleted of PMNs with Sepacell or Pall filters (less than 0.1 x 10(3) cells/microliters) was greatly blunted, with flow and contractile function falling by less than 14 and 8%, respectively, from baseline, and release of TxB2 was greatly attenuated. However, the myocardial ischemia and TxB2 release remained depressed in response to C5a after removal of the filters and perfusion with either arterial blood containing normal levels of PMNs or stored arterial blood never exposed to filters. In contrast, the repeat C5a challenge resulted in equivalent myocardial extraction of PMNs, thus indicating a dissociation of PMN sequestration from the acute ischemic response and release of TxB2. In separate experiments, the intracoronary injection of LTB4 also resulted in a pronounced myocardial extraction of PMNs (8.6 x 10(3) cells/microliters) greater than during C5a, but did not depress coronary flow or function. Perfusion at constant flow greatly diminished the ischemic response to C5a, indicating that vasoconstriction and resultant ischemia is the main cause of the contractile dysfunction. These data indicate that leukocyte filters inhibit the myocardial ischemia and release of TxB2 induced by C5a via mechanisms not related to PMN depletion.(ABSTRACT TRUNCATED AT 400 WORDS) JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Engler, R L AU - Roth, D M AU - del Balzo, U AU - Ito, B R AD - Department of Medicine and Pathology, Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 2983 EP - 2991 VL - 5 IS - 14 SN - 0892-6638, 0892-6638 KW - SRS-A KW - 0 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Swine KW - Myocardial Reperfusion Injury -- chemically induced KW - Hemodynamics -- drug effects KW - Myocardial Reperfusion Injury -- blood KW - Animals KW - Leukotriene B4 -- blood KW - Coronary Vessels KW - Injections, Intra-Arterial KW - Filtration -- instrumentation KW - SRS-A -- blood KW - Myocardial Reperfusion Injury -- physiopathology KW - Cell Adhesion KW - Coronary Disease -- blood KW - Coronary Disease -- physiopathology KW - Coronary Disease -- chemically induced KW - Neutrophils -- physiology KW - Complement C5a -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72551930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Intracoronary+C5a+induces+myocardial+ischemia+by+mechanisms+independent+of+the+neutrophil%3A+leukocyte+filters+desensitize+the+myocardium+to+C5a.&rft.au=Engler%2C+R+L%3BRoth%2C+D+M%3Bdel+Balzo%2C+U%3BIto%2C+B+R&rft.aulast=Engler&rft.aufirst=R&rft.date=1991-11-01&rft.volume=5&rft.issue=14&rft.spage=2983&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-29 N1 - Date created - 1992-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Production of a factor, or factors, suppressing IL-2 production and T cell proliferation by Sertoli cell-enriched preparations. A potential role for islet transplantation in an immunologically privileged site. AN - 72482432; 1949171 AB - Isolated islet allografts survive indefinitely in the abdominal testis of nonimmunosuppressed diabetic rats. The predominant feature of these testes is that the presence of Sertoli cells, but not Leydig cells, is required for extended survival of the islet allografts. Sertoli cells cultures were therefore established in vitro and we examined the effects of the conditioned media on Con A--stimulated spleen lymphocyte proliferation. These studies revealed that a product(s) secreted by Sertoli cells inhibits Con A-stimulated lymphocyte proliferation in a dose-dependent manner. The synthesis of this product is both temperature-dependent, occurring predominantly at 37 degrees C, and hormone-dependent, requiring the presence of follicle stimulating hormone, in the culture medium. We further examined the mechanism of inhibition of lymphocyte proliferation and showed that Sertoli cell-enriched media inhibit the production of IL-2 in a dose-dependent manner. Furthermore, the finding that the addition of exogenous IL-2 is not able to reverse this inhibition indicates that the Sertoli cell-enriched media inhibit both IL-2 production and IL-2 responsiveness of T lymphocytes. JF - Transplantation AU - Selawry, H P AU - Kotb, M AU - Herrod, H G AU - Lu, Z N AD - Veterans Administration Medical Center, Memphis, Tennessee. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 846 EP - 850 VL - 52 IS - 5 SN - 0041-1337, 0041-1337 KW - Interleukin-2 KW - 0 KW - Concanavalin A KW - 11028-71-0 KW - Testosterone KW - 3XMK78S47O KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Index Medicus KW - Animals KW - Rats, Inbred Strains KW - Rats KW - Testosterone -- pharmacology KW - Cells, Cultured KW - Dose-Response Relationship, Immunologic KW - In Vitro Techniques KW - Hot Temperature -- adverse effects KW - Cytotoxicity Tests, Immunologic KW - Follicle Stimulating Hormone -- pharmacology KW - Drug Antagonism KW - Female KW - Male KW - Lymphocyte Activation -- drug effects KW - Interleukin-2 -- biosynthesis KW - Sertoli Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72482432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Production+of+a+factor%2C+or+factors%2C+suppressing+IL-2+production+and+T+cell+proliferation+by+Sertoli+cell-enriched+preparations.+A+potential+role+for+islet+transplantation+in+an+immunologically+privileged+site.&rft.au=Selawry%2C+H+P%3BKotb%2C+M%3BHerrod%2C+H+G%3BLu%2C+Z+N&rft.aulast=Selawry&rft.aufirst=H&rft.date=1991-11-01&rft.volume=52&rft.issue=5&rft.spage=846&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-16 N1 - Date created - 1991-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes. Role of hydroxyl radical and protection by heat shock. AN - 72451308; 1658042 AB - Leishmania must survive despite exposure to the toxic oxidant hydrogen peroxide (H2O2) during phagocytosis by macrophages. We investigated the mechanism of H2O2 toxicity for L. donovani chagasi promastigotes, and factors responsible for their relative H2O2 resistance. There was a dose-dependent toxic effect of H2O2 for promastigotes isolated during logarithmic phase of growth. In contrast, stationary phase promastigotes were less susceptible to H2O2 toxicity, and more infectious for BALB/c mice. By spin trapping we found that hydroxyl radical (.OH) was generated after exposure of promastigotes to H2O2, and the amount of .OH was greater with log-phase than with stationary-phase promastigotes. .OH was generated after the addition of H2O2 to the cytosol but not the membranes of fractionated promastigotes, and the magnitude of .OH was greater in log than in stationary promastigote cytosol. Deferoxamine inhibition suggested that intracellular promastigote iron catalyzes .OH formation via the Fenton reaction. Furthermore, exposure of log-phase promastigotes to heat shock induced a relative H2O2-resistant state, which was not associated with a decrease in .OH formation but which required ongoing transcription. Thus, growth to stationary phase and heat shock both induce a state of relative H2O2 resistance, but these are probably due to different resistance mechanisms. JF - The Journal of clinical investigation AU - Zarley, J H AU - Britigan, B E AU - Wilson, M E AD - Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 1511 EP - 1521 VL - 88 IS - 5 SN - 0021-9738, 0021-9738 KW - Cyclic N-Oxides KW - 0 KW - Heat-Shock Proteins KW - Hydroxides KW - Hydroxyl Radical KW - 3352-57-6 KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Deferoxamine KW - J06Y7MXW4D KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Abridged Index Medicus KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals KW - Deferoxamine -- pharmacology KW - Humans KW - Macrophages -- physiology KW - Heat-Shock Proteins -- biosynthesis KW - Transcription, Genetic KW - Mice KW - Phagocytosis KW - Hot Temperature KW - Hydrogen Peroxide -- pharmacology KW - Leishmania donovani -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72451308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Hydrogen+peroxide-mediated+toxicity+for+Leishmania+donovani+chagasi+promastigotes.+Role+of+hydroxyl+radical+and+protection+by+heat+shock.&rft.au=Zarley%2C+J+H%3BBritigan%2C+B+E%3BWilson%2C+M+E&rft.aulast=Zarley&rft.aufirst=J&rft.date=1991-11-01&rft.volume=88&rft.issue=5&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-13 N1 - Date created - 1991-12-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1987 Nov;55(11):2802-6 [3666964] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4414-7 [3859870] Acta Physiol Scand Suppl. 1986;548:9-37 [3019082] Arch Biochem Biophys. 1986 May 1;246(2):501-14 [3010861] Annu Rev Med. 1986;37:61-9 [3010809] J Biol Chem. 1986 Apr 5;261(10):4426-31 [3007455] Eur J Immunol. 1987 Feb;17(2):203-8 [3030768] Infect Immun. 1988 Feb;56(2):363-9 [2962944] Cell. 1986 Sep 26;46(7):959-61 [2944601] J Immunol. 1991 Apr 15;146(8):2747-53 [1707920] Curr Top Microbiol Immunol. 1991;167:125-43 [2055094] Mol Biochem Parasitol. 1990 Sep-Oct;42(2):225-33 [2176718] Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1313-9 [2123614] J Immunol. 1987 Nov 1;139(9):3099-106 [3312412] J Bacteriol. 1988 Sep;170(9):3910-4 [3045081] Science. 1988 Jun 3;240(4857):1302-9 [3287616] J Bacteriol. 1989 Jul;171(7):3933-9 [2472381] Annu Rev Biochem. 1986;55:1151-91 [2427013] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2453-7 [2538841] Immunol Today. 1989 Oct;10(10):328-33 [2679629] Eur J Biochem. 1989 Mar 15;180(2):267-72 [2647489] Nucleic Acids Res. 1989 Jul 11;17(13):5081-95 [2762121] J Immunol. 1989 Jul 15;143(2):678-84 [2738406] Proc Natl Acad Sci U S A. 1989 Apr;86(8):2607-11 [2704738] Immunol Today. 1988 May;9(5):134-7 [3256318] EMBO J. 1988 Sep;7(9):2895-901 [3181145] J Immunol. 1988 Jul 1;141(1):265-72 [3379307] Exp Parasitol. 1988 Feb;65(1):1-9 [3338542] Infect Immun. 1987 Mar;55(3):587-93 [3546131] Parasitology. 1985 Oct;91 ( Pt 2):207-17 [4069752] Parasitology. 1985 Oct;91 ( Pt 2):197-206 [4069751] Science. 1985 Jun 21;228(4706):1443-6 [4012301] J Immunol. 1990 Jun 15;144(12):4794-7 [2351828] J Immunol. 1990 Jan 1;144(1):278-83 [2104889] Science. 1990 May 11;248(4956):730-2 [1970672] J Biol Chem. 1990 Feb 15;265(5):2973-8 [2406243] J Clin Invest. 1983 Jul;72(1):32-44 [6308049] J Biol Chem. 1984 Sep 25;259(18):11173-5 [6088532] J Immunol. 1982 Jul;129(1):351-7 [6282967] J Biol Chem. 1981 Jul 25;256(14):7094-6 [6265438] J Reticuloendothel Soc. 1981 Mar;29(3):181-92 [6260943] Rev Infect Dis. 1983 Sep-Oct;5(5):907-927 [6356272] Cell. 1983 Dec;35(3 Pt 2):603-10 [6606489] Science. 1984 Mar 30;223(4643):1417-9 [6701528] J Immunol. 1983 Oct;131(4):1994-9 [6619546] J Immunol. 1982 Sep;129(3):1282-6 [7108206] J Exp Med. 1981 Jun 1;153(6):1690-5 [7252424] J Exp Med. 1981 May 1;153(5):1302-15 [7252418] J Immunol. 1980 Nov;125(5):2195-201 [7430624] J Exp Med. 1977 Dec 1;146(6):1613-26 [925613] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Science. 1986 Mar 7;231(4742):1154-7 [3511530] Biochem Biophys Res Commun. 1987 Oct 29;148(2):653-7 [3689364] J Immunol. 1987 Jan 1;138(1):299-305 [3782801] J Immunol. 1986 Jun 15;136(12):4681-8 [3711662] J Exp Med. 1985 Jul 1;162(1):324-31 [3891904] Nucleic Acids Res. 1988 Oct 25;16(20):9567-85 [3186441] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Outreach Health Services for Street Youth AN - 61644429; 199302066 AB - Based on a review of charts & clinic logs, medical problems are explored among 609 youths, average age 16 years, 9 months, seen 1985-1989 at a voluntary health agency operating a clinic at a drop-in center for street youth in Portland, Ore. There were 2,086 diagnoses made during 1,895 visits. Respiratory, dermatologic, & gynecologic problems represented 56% of all diagnoses. Pregnancy tests accounted for 38% of all procedures, 50% of all medications dispensed were either oral antibiotics or decongestants, & 17% of the visits resulted in referrals. Problems related to substance abuse & sexually transmitted diseases were seen much less frequently than anticipated. Elements critical to the success of this clinic included its on-site location, hours of operation, close working relationships between clinic & center staffs, the capability to perform a few simple laboratory procedures, & an on-site pharmacy. 4 Tables, 26 References. Adapted from the source document. JF - Journal of Adolescent Health AU - Reuler, James B AD - Section General Medicine Veterans Administration Medical Center, PO Box 1034 Portland OR 92207 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 561 EP - 566 VL - 12 IS - 7 SN - 1054-139X, 1054-139X KW - medical problems, street youths KW - charts, clinic logs KW - drop-in center, Portland, Oregon KW - Portland, Oregon KW - Health Problems KW - Youth KW - Homelessness KW - article KW - 6124: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61644429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Outreach+Health+Services+for+Street+Youth&rft.au=Reuler%2C+James+B&rft.aulast=Reuler&rft.aufirst=James&rft.date=1991-11-01&rft.volume=12&rft.issue=7&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Homelessness; Youth; Portland, Oregon; Health Problems ER - TY - JOUR T1 - Right Hemisphere Participation in Reading AN - 58243208; 9200630 AB - It was hypothesized that the right cerebral hemisphere's contribution to lexical semantic processing, in skilled readers, is greatest when the hemisphere is "released" from inhibition. An experiment was designed using a set of tasks to overload the left hemisphere, thus disinhibiting right-hemisphere reading processes. Right-handed undergraduates (N = 18 males & 15 females) were tested in four dual-task & five single-task conditions. The primary task was a lateralized semantic or rhyme task. Visual stimuli were presented tachistoscopically & Ss were instructed to press a response button with the hand ipsilateral to the stimulus. Reaction time for correct "related" trials (those in which the centrally presented target word & laterally presented word were semantically related or phonologically related) were analyzed. The pattern of results suggests that interhemispheric inhibition & disinhibition are greater in some individuals than in others. The degree of inhibition of right-hemisphere function in the single-task semantic conditions was associated with the degree of disinhibition in the dual-task left visual field semantic condition. For one subgroup, findings supported the initial hypothesis. Some suggestions for future research are outlined. 1 Table, 1 Figure, 72 References. B. Annesser Murray JF - Brain and Language AU - Hutner, Nancy AU - Liederman, Jacqueline AD - Boston Veterans Administration Medical Center, 150 South Huntington Ave MA 02130 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 475 EP - 495 VL - 41 IS - 4 SN - 0093-934X, 0093-934X KW - right hemisphere role, lexical semantic processing, inhibition release effects KW - empirical data KW - undergraduates KW - Cerebral Dominance (11500) KW - Handedness (30450) KW - Brain (09350) KW - Reading Processes (71150) KW - article KW - 4119: applied linguistics; reading processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58243208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Right+Hemisphere+Participation+in+Reading&rft.au=Hutner%2C+Nancy%3BLiederman%2C+Jacqueline&rft.aulast=Hutner&rft.aufirst=Nancy&rft.date=1991-11-01&rft.volume=41&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Brain (09350); Reading Processes (71150); Cerebral Dominance (11500); Handedness (30450) ER - TY - JOUR T1 - Writing with the Right Hemisphere AN - 58214956; 9200156 AB - The possible role of the right cerebral hemisphere in writing & spelling is discussed with reference to the case history of a patient suffering a massive left-hemisphere stroke that virtually destroyed that hemisphere. A detailed analysis was conducted of the patient's remaining language abilities, including oral language, writing, oral spelling, & reading. It is assumed that these abilities were relegated only to the right hemisphere after the stroke. The patient was totally uanble to spell nonwords to dictation, but could write real words. This writing, however, was significantly affected by lexical-semantic variables, eg, word frequency & part of speech. The patient could write some words correctly but could not spell orally at all. It is suggested that the linguistic abilities of this patient may have been greater than expected due to continued linguistic development following his unusual survivial of the massive stroke. 2 Tables, 1 Figure, 71 References. B. Annesser Murray JF - Brain and Language AU - Rapcsak, Steven Z AU - Beeson, Pelagie M AU - Rubens, Alan B AD - Neurology Service Veterans Administration Medical Center, 3601 South 6th Ave Tucson AZ 85723 Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 510 EP - 530 VL - 41 IS - 4 SN - 0093-934X, 0093-934X KW - right hemisphere role, writing words/nonwords KW - case history KW - Cerebral Dominance (11500) KW - Nervous System Disorders (57100) KW - Writing Disorders (98650) KW - Neurolinguistics (57250) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58214956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Writing+with+the+Right+Hemisphere&rft.au=Rapcsak%2C+Steven+Z%3BBeeson%2C+Pelagie+M%3BRubens%2C+Alan+B&rft.aulast=Rapcsak&rft.aufirst=Steven&rft.date=1991-11-01&rft.volume=41&rft.issue=4&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Cerebral Dominance (11500); Neurolinguistics (57250); Nervous System Disorders (57100); Writing Disorders (98650) ER - TY - JOUR T1 - A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. AN - 72484151; 1719969 AB - Protein kinase C (PKC) is routinely assayed, after it is partially purified over DEAE-cellulose chromatography to eliminate any interfering protein kinases and phosphatases, by measuring the transfer of gamma-phosphate of [gamma-32P]ATP to H1 histone. Recently, it has been shown that a synthetic peptide, comprising residues 4-14 of myelin basic protein (MBP4-14), is a very selective PKC substrate which is not phosphorylated effectively by cyclic AMP-dependent protein kinase, casein kinase I and II, Ca2+/calmodulin dependent protein kinase II or phosphorylase kinase [Yasuda, I., Kishimoto, A., Tanaka, S-I., Tominaga, M., Sakurai, A. and Nishizuka, Y. (1990) BBRC 166, 1220-1227]. We report here that once MBP4-14 is phosphorylated, it is not dephosphorylated by okadaic acid-sensitive phosphatases (protein phosphatases 1, 2A and 3) or other protein phosphatases such as calcineurin and/or PP 2C present in hippocampal homogenates. Therefore, MBP4-14 can be used for PKC assay in crude extracts of neural tissue. JF - Biochemical and biophysical research communications AU - Farrar, Y J AU - Vanaman, T C AU - Slevin, J T AD - Veterans Administration Medical Center, Lexington, KY 40511. Y1 - 1991/10/31/ PY - 1991 DA - 1991 Oct 31 SP - 694 EP - 701 VL - 180 IS - 2 SN - 0006-291X, 0006-291X KW - Ethers, Cyclic KW - 0 KW - Myelin Basic Protein KW - Oligopeptides KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Protein Kinase C KW - EC 2.7.11.13 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Index Medicus KW - Animals KW - Amino Acid Sequence KW - Myelin Basic Protein -- chemical synthesis KW - Ethers, Cyclic -- pharmacology KW - Oligopeptides -- chemical synthesis KW - Rats, Inbred Strains KW - Rats KW - Chromatography, DEAE-Cellulose KW - Kinetics KW - Molecular Sequence Data KW - Myelin Basic Protein -- metabolism KW - Substrate Specificity KW - Male KW - Adenosine Triphosphate -- pharmacology KW - Protein Kinase C -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Protein Kinase C -- isolation & purification KW - Hippocampus -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=A+phosphatase+resistant+substrate+for+the+assay+of+protein+kinase+C+in+crude+tissue+extracts.&rft.au=Farrar%2C+Y+J%3BVanaman%2C+T+C%3BSlevin%2C+J+T&rft.aulast=Farrar&rft.aufirst=Y&rft.date=1991-10-31&rft.volume=180&rft.issue=2&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-02 N1 - Date created - 1991-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction. AN - 72174495; 1932130 AB - The mechanism of phospholipase A2 activation by chemotactic peptide was investigated in human promyelocytic HL60 cells. N-Formyl-methionyl-leucyl-phenylalanine (fMetLeuPhe) and the non-hydrolyzable GTP analogue guanosine 5'-[gamma-thio]triphosphate (GTP[S]) induced arachidonic acid release in permeabilized and metabolically inhibited HL60 cells, a preparation in which calcium was buffered and inositol phospholipid hydrolysis was inhibited. Inositol phosphate generation and arachidonic acid were shown to be temporally dissociated. These results suggest that receptor-dependent phospholipase C activity is not required for fMetLeuPhe to induce arachidonic acid release. However, fMetLeuPhe effects were highly calcium-dependent and inhibition of phospholipase C reduced fMetLeuPhe stimulation of arachidonic acid release even in the permeabilized cell preparation. We conclude that although phospholipase A2 activation is linked to the fMetLeuPhe receptor independent of phospholipase C, actions of phospholipase C to mobilize calcium and release diacylglycerol may be important to phospholipase A2 activation in the intact cell. JF - Biochimica et biophysica acta AU - Nielson, C P AU - Stutchfield, J AU - Cockcroft, S AD - Clinical Pharmacology and Gerontology Research Unit, Veterans Administration Medical Center, Boise, ID. Y1 - 1991/10/16/ PY - 1991 DA - 1991 Oct 16 SP - 83 EP - 89 VL - 1095 IS - 1 SN - 0006-3002, 0006-3002 KW - Inositol Phosphates KW - 0 KW - Neomycin KW - 1404-04-2 KW - Arachidonic Acid KW - 27YG812J1I KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Type C Phospholipases KW - EC 3.1.4.- KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Tumor Cells, Cultured KW - Inositol Phosphates -- metabolism KW - Enzyme Activation KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Neomycin -- pharmacology KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Phospholipases A -- metabolism KW - Adenosine Triphosphate -- pharmacology KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - GTP-Binding Proteins -- metabolism KW - Signal Transduction KW - Arachidonic Acid -- metabolism KW - Type C Phospholipases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72174495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Chemotactic+peptide+stimulation+of+arachidonic+acid+release+in+HL60+cells%2C+an+interaction+between+G+protein+and+phospholipase+C+mediated+signal+transduction.&rft.au=Nielson%2C+C+P%3BStutchfield%2C+J%3BCockcroft%2C+S&rft.aulast=Nielson&rft.aufirst=C&rft.date=1991-10-16&rft.volume=1095&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-11 N1 - Date created - 1991-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunological effects of levamisole in vitro. AN - 72640435; 1790137 AB - Levamisole, an anthelminthic drug with immunological properties, has recently been reported to have antitumor activity when administered with 5-fluorouracil in patients with Duke's C colorectal carcinoma. The mechanism of this antitumor effect is unknown, but has been postulated to be related to levamisole's immunomodulatory properties. To define further the immunomodulatory activities of levamisole, we studied the in vitro effects of levamisole on monocyte and lymphocyte cytotoxicity, activation, and proliferation; induction of cytokine-induced proteins; and expression of tumor-associated antigens. Experiments utilized peripheral blood mononuclear cells from normal donors incubated in the presence of increasing concentrations of levamisole (0.1 to 100 micrograms/ml). Levamisole had no consistent effect on induction of 2',5'-oligoadenylate synthetase activity or indoleamine-2,3-dioxygenase activity, or production of tumor necrosis factor. Levamisole had no effect on monocyte cytotoxicity or expression of HLA-DR, HLA-DQ, HLA-DP, and the Fc receptor. Similarly, levamisole had no significant effect on NK or LAK cytotoxicity or the immunological activation of T-lymphocytes, assessed by expression of CD3, CD4, CD8, CD16, CD25, and CD56. Proliferation of lymphocytes from normal donors, patients with benign polyps, and patients with malignancies, with or without IL-2 or irradiated LS174T cells, was not significantly increased overall. No significant enhancement in the expression of three tumor-associated antigens (880364, NRCO-4, and ING-1) and the intercellular adhesion molecule-1 (ICAM-1) antigen on four human cancer cell lines was observed following in vitro exposure to levamisole. We conclude that levamisole is not a potent modulator of the immune parameters we examined, and that the mechanism behind the unique clinical interaction between levamisole and 5-fluorouracil in colorectal carcinoma remains to be identified. JF - Journal of immunotherapy : official journal of the Society for Biological Therapy AU - Schiller, J H AU - Lindstrom, M AU - Witt, P L AU - Hank, J A AU - Mahvi, D AU - Wagner, R J AU - Sondel, P AU - Borden, E C AD - Department of Human Oncology, William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 297 EP - 306 VL - 10 IS - 5 SN - 1053-8550, 1053-8550 KW - Antigens, Neoplasm KW - 0 KW - Antigens, Surface KW - Antineoplastic Agents KW - Tumor Necrosis Factor-alpha KW - Levamisole KW - 2880D3468G KW - Tryptophan Oxygenase KW - EC 1.13.11.11 KW - 2',5'-Oligoadenylate Synthetase KW - EC 2.7.7.84 KW - Index Medicus KW - Tryptophan Oxygenase -- biosynthesis KW - Humans KW - Killer Cells, Lymphokine-Activated -- immunology KW - Antigens, Neoplasm -- analysis KW - Cell Division -- drug effects KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - 2',5'-Oligoadenylate Synthetase -- biosynthesis KW - Tryptophan Oxygenase -- metabolism KW - Tumor Cells, Cultured KW - Monocytes -- immunology KW - Cytotoxicity Tests, Immunologic KW - Monocytes -- drug effects KW - 2',5'-Oligoadenylate Synthetase -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunophenotyping KW - Lymphocytes -- drug effects KW - Antigens, Surface -- analysis KW - Killer Cells, Natural -- immunology KW - Levamisole -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72640435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.atitle=Immunological+effects+of+levamisole+in+vitro.&rft.au=Schiller%2C+J+H%3BLindstrom%2C+M%3BWitt%2C+P+L%3BHank%2C+J+A%3BMahvi%2C+D%3BWagner%2C+R+J%3BSondel%2C+P%3BBorden%2C+E+C&rft.aulast=Schiller&rft.aufirst=J&rft.date=1991-10-01&rft.volume=10&rft.issue=5&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.issn=10538550&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-31 N1 - Date created - 1992-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Signal transduction by the human thyrotropin receptor: studies on the role of individual amino acid residues in the carboxyl terminal region of the third cytoplasmic loop. AN - 72628596; 1663578 AB - We observed previously that the carboxyl-terminal region of the third loop of the TSH receptor (amino acid residues 617-625) is important in signal transduction. To analyze this region in more detail, in the present study we used site-directed mutagenesis to substitute, on an individual basis, the seven amino acids previously mutated as a group. These amino acids are either charged residues or potential phosphorylation sites. Six of the mutant TSH receptors with individual amino acid substitutions bound TSH with high affinity and displayed a cAMP response to TSH stimulation similar to the wild-type TSH receptor. The mutant receptor TSH-R-Gly625 (Arg----Gly) did not transduce a signal, but these results are noninformative because of the loss of high affinity TSH binding. The present data indicate that for each of the six informative amino acid substitutions, the individual residues are not critical for signal transduction. A corollary of this conclusion is that in the important carboxyl-terminal region of the third cytoplasmic loop of the TSH receptor multiple amino acid residues function as a unit. JF - Molecular endocrinology (Baltimore, Md.) AU - Chazenbalk, G D AU - Nagayama, Y AU - Wadsworth, H AU - Russo, D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 1523 EP - 1526 VL - 5 IS - 10 SN - 0888-8809, 0888-8809 KW - Receptors, Thyrotropin KW - 0 KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Models, Structural KW - Transfection KW - Kinetics KW - Humans KW - Genetic Vectors KW - Restriction Mapping KW - Molecular Sequence Data KW - Cyclic AMP -- metabolism KW - CHO Cells KW - Amino Acid Sequence KW - Protein Conformation KW - Cricetinae KW - Mutagenesis, Site-Directed KW - Thyrotropin -- pharmacology KW - Receptors, Thyrotropin -- physiology KW - Thyrotropin -- metabolism KW - Signal Transduction KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72628596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Signal+transduction+by+the+human+thyrotropin+receptor%3A+studies+on+the+role+of+individual+amino+acid+residues+in+the+carboxyl+terminal+region+of+the+third+cytoplasmic+loop.&rft.au=Chazenbalk%2C+G+D%3BNagayama%2C+Y%3BWadsworth%2C+H%3BRusso%2C+D%3BRapoport%2C+B&rft.aulast=Chazenbalk&rft.aufirst=G&rft.date=1991-10-01&rft.volume=5&rft.issue=10&rft.spage=1523&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-05 N1 - Date created - 1992-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A randomized trial of cefepime (BMY-28142) and ceftazidime for the treatment of pneumonia. AN - 72586696; 1761451 AB - Cefepime is a new cephalosporin with a broad antimicrobial spectrum that includes Staphylococcus aureus and Pseudomonas aeruginosa. To study the efficacy and safety of cefepime for treatment of pneumonia, 65 patients were randomized to therapy with either cefepime or ceftazidime at a two to one ratio. Of the 57 evaluable patients, 89% of the cefepime patients and 84% of the ceftazidime patients were cured clinically or improved. Haemophilus spp., Streptococcus pneumoniae, and Neisseria spp. were common pathogens. Bacteriological cure was achieved in 31 (91%) of cefepime patients and 17 (100%) ceftazidime patients. Adverse clinical and laboratory reactions possibly due to study drug occurred in 9 (21%) cefepime patients and in 1 (5%) ceftazidime patient. Most reactions were mild and resolved with discontinuation of study drug. In this study, cefepime appeared as effective as ceftazidime for the treatment of pneumonia. JF - The Journal of antimicrobial chemotherapy AU - Edelstein, H AU - Chirurgi, V AU - Oster, S AU - Karp, R AU - Cassano, K AU - Aiken, S AU - McCabe, R AD - Medical Service, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 569 EP - 575 VL - 28 IS - 4 SN - 0305-7453, 0305-7453 KW - Cephalosporins KW - 0 KW - cefepime KW - 807PW4VQE3 KW - Ceftazidime KW - 9M416Z9QNR KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Bacteria -- drug effects KW - Aged KW - Middle Aged KW - Microbial Sensitivity Tests KW - Drug Hypersensitivity KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Ceftazidime -- adverse effects KW - Pneumonia -- microbiology KW - Ceftazidime -- therapeutic use KW - Cephalosporins -- therapeutic use KW - Pneumonia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72586696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=A+randomized+trial+of+cefepime+%28BMY-28142%29+and+ceftazidime+for+the+treatment+of+pneumonia.&rft.au=Edelstein%2C+H%3BChirurgi%2C+V%3BOster%2C+S%3BKarp%2C+R%3BCassano%2C+K%3BAiken%2C+S%3BMcCabe%2C+R&rft.aulast=Edelstein&rft.aufirst=H&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ceftibuten versus cefaclor for the treatment of bronchitis. AN - 72580426; 1761452 AB - Ceftibuten is an oral third generation cephalosporin with potent antimicrobial activity against Enterobacteriaceae, beta-lactamase positive Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrheae, penicillin-susceptible pneumococci, and beta-hemolytic streptococci. To study the efficacy and safety of ceftibuten for treatment of bronchitis, 58 patients were randomized to therapy with either ceftibuten 400 mg once a day or cefaclor 250 mg every 8 h at a ratio of two to one. Of 45 clinically evaluable patients, 28 (87.5%) of the 32 ceftibuten patients and 12 (92.3%) of the 13 cefaclor patients were clinically improved or cured. Of 33 microbiologically evaluable patients, 21 (87.5%) of the 24 ceftibuten patients and eight (80%) of the ten cefaclor patients were cured. Of 56 patients evaluable for adverse effects, three (7.9%) of the 38 ceftibuten patients and one (5.6%) of the 18 cefaclor patients had adverse reactions. In this small study, once-daily ceftibuten appeared as safe and as effective as cefaclor for the treatment of bronchitis. JF - The Journal of antimicrobial chemotherapy AU - Chirurgi, V A AU - Edelstein, H AU - Oster, S E AU - Karp, R AU - Cassano, K B AU - Aiken, S AU - Krumpe, P AU - McCabe, R E AD - Medical Service, Veterans Administration Medical Center, Martinez, California USA 94553. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 577 EP - 580 VL - 28 IS - 4 SN - 0305-7453, 0305-7453 KW - Cephalosporins KW - 0 KW - Cefaclor KW - 69K7K19H4L KW - ceftibuten KW - IW71N46B4Y KW - Index Medicus KW - Humans KW - Bacteria -- drug effects KW - Microbial Sensitivity Tests KW - Male KW - Female KW - Cephalosporins -- adverse effects KW - Bronchitis -- drug therapy KW - Cefaclor -- therapeutic use KW - Cefaclor -- administration & dosage KW - Cephalosporins -- therapeutic use KW - Bronchitis -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72580426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Ceftibuten+versus+cefaclor+for+the+treatment+of+bronchitis.&rft.au=Chirurgi%2C+V+A%3BEdelstein%2C+H%3BOster%2C+S+E%3BKarp%2C+R%3BCassano%2C+K+B%3BAiken%2C+S%3BKrumpe%2C+P%3BMcCabe%2C+R+E&rft.aulast=Chirurgi&rft.aufirst=V&rft.date=1991-10-01&rft.volume=28&rft.issue=4&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-13 N1 - Date created - 1992-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Noncirrhotic liver dysfunction and neuropsychologic impairment. AN - 72568209; 1755526 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 899 EP - 900 VL - 15 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Hepatic Encephalopathy -- psychology KW - Hepatic Encephalopathy -- diagnosis KW - Liver Diseases, Alcoholic -- psychology KW - Substance-Related Disorders -- psychology KW - Neuropsychological Tests KW - Liver Diseases, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72568209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Noncirrhotic+liver+dysfunction+and+neuropsychologic+impairment.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-10-01&rft.volume=15&rft.issue=5&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-28 N1 - Date created - 1992-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antabuse (disulfiram) and AIDS. AN - 72563698; 1684488 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 900 EP - 901 VL - 15 IS - 5 SN - 0145-6008, 0145-6008 KW - Carbamates KW - 0 KW - Disulfides KW - dioxiram KW - 59547-11-4 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - AIDS/HIV KW - Leukocyte Count -- drug effects KW - Humans KW - CD4-Positive T-Lymphocytes -- drug effects KW - Disulfides -- pharmacokinetics KW - Alcoholism -- rehabilitation KW - Carbamates -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Disulfiram -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- immunology KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Aldehyde Dehydrogenase -- antagonists & inhibitors KW - Disulfiram -- pharmacokinetics KW - Disulfides -- therapeutic use KW - Alcoholism -- immunology KW - Carbamates -- pharmacokinetics KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72563698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Antabuse+%28disulfiram%29+and+AIDS.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-10-01&rft.volume=15&rft.issue=5&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-28 N1 - Date created - 1992-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacological evaluation of early afterdepolarisations induced by sea anemone toxin (ATXII) in dog heart. AN - 72550010; 1684137 AB - ATXII is a polypeptide toxin isolated from the sea anemone, Anemonia sulcata, known to delay sodium inactivation markedly and to induce early afterdepolarisations. The aim was to investigate the mechanism of its action. The mechanism of ATXII induced early afterdepolarisations was investigated in vitro in canine endocardial preparations using standard microelectrode techniques. ATXII (2 x 10(-7) M) induced cycle length dependent prolongation of plateau, more marked in Purkinje than in muscle fibres, and early afterdepolarisations in Purkinje fibres only. The calcium channel antagonists verapamil (10(-6) M, 10(-5) M) and cobalt (2-4 mM), and drugs that block calcium release from the sarcoplasmic reticulum, ryanodine (10(-6) M, 10(-5) M) and caffeine (10 mM), did not antagonise the ATXII effects. However, tetrodotoxin (5 x 10(-6) M) and lignocaine (4 x 10(-5) M) shortened the action potential and suppressed early afterdepolarisations. The effects of lignocaine were seen at concentrations that did not significantly affect Vmax. ATXII induced early after depolarisations are due to the effects of ATXII on Na+ entry, probably via a slowly inactivated Na+ channel population. Calcium entry through the sarcolemmal Ca2+ channels and cyclic Ca2+ release from the sarcoplasmic reticulum are not required for the genesis of early afterdepolarisations in this model. JF - Cardiovascular research AU - Boutjdir, M AU - el-Sherif, N AD - Cardiology Division (111), Veterans Administration Medical Center (State University of New York), Brooklyn 11209. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 815 EP - 819 VL - 25 IS - 10 SN - 0008-6363, 0008-6363 KW - Calcium Channels KW - 0 KW - Cardiotonic Agents KW - Cnidarian Venoms KW - Sodium Channels KW - toxin II (Anemonia sulcata) KW - 60748-45-0 KW - Index Medicus KW - Purkinje Fibers -- drug effects KW - Evoked Potentials -- drug effects KW - Animals KW - Sea Anemones KW - Culture Techniques KW - Calcium Channels -- physiology KW - Sarcoplasmic Reticulum -- physiology KW - Dogs KW - Sodium Channels -- physiology KW - Electric Stimulation KW - Sodium Channels -- drug effects KW - Cardiotonic Agents -- pharmacology KW - Endocardium -- drug effects KW - Endocardium -- physiology KW - Cnidarian Venoms -- antagonists & inhibitors KW - Cnidarian Venoms -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72550010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+research&rft.atitle=Pharmacological+evaluation+of+early+afterdepolarisations+induced+by+sea+anemone+toxin+%28ATXII%29+in+dog+heart.&rft.au=Boutjdir%2C+M%3Bel-Sherif%2C+N&rft.aulast=Boutjdir&rft.aufirst=M&rft.date=1991-10-01&rft.volume=25&rft.issue=10&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+research&rft.issn=00086363&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-22 N1 - Date created - 1992-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Similarities and differences between MMPI and MMPI-2 applications to the assessment of posttraumatic stress disorder. AN - 72486576; 1955973 AB - The purpose of this study was to address the question: Is the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) comparable to the original MMPI in its applicability to the assessment of posttraumatic stress disorder (PTSD) among Vietnam combat veterans? The question was addressed by administering both the original MMPI and MMPI-2 to 29 subjects classified as meeting Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; DSM-III-R) criteria for PTSD and comparing MMPI and MMPI-2 scores in terms of: degree of association, code-type congruence, diagnostic hit rates (when compared to two other clinical samples, and one normal sample), and congruence of the Keane PTSD Scale (PK). Results reveal highly significant correlations between MMPI and MMPI-2 basic scales for the PTSD sample as well as congruence in 2-point codes comparable to previous studies. The MMPI-2 was found to identify effectively PTSD subjects from the other groups. Results also showed a high degree of association between the MMPI and MMPI-2 in regard to PK scores, although minor differences were found in PK raw scores between the two tests. Overall, the findings suggest a high degree of comparability between the MMPI and MMPI-2 in the assessment of PTSD. JF - Journal of personality assessment AU - Litz, B T AU - Penk, W E AU - Walsh, S AU - Hyer, L AU - Blake, D D AU - Marx, B AU - Keane, T M AU - Bitman, D AD - Boston Veterans Administration Medical Center. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 238 EP - 253 VL - 57 IS - 2 SN - 0022-3891, 0022-3891 KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Reproducibility of Results KW - Humans KW - Adult KW - Middle Aged KW - Substance-Related Disorders -- psychology KW - Psychometrics KW - Male KW - Female KW - Vietnam KW - Combat Disorders -- psychology KW - Veterans -- psychology KW - MMPI -- statistics & numerical data KW - Combat Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72486576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+assessment&rft.atitle=Similarities+and+differences+between+MMPI+and+MMPI-2+applications+to+the+assessment+of+posttraumatic+stress+disorder.&rft.au=Litz%2C+B+T%3BPenk%2C+W+E%3BWalsh%2C+S%3BHyer%2C+L%3BBlake%2C+D+D%3BMarx%2C+B%3BKeane%2C+T+M%3BBitman%2C+D&rft.aulast=Litz&rft.aufirst=B&rft.date=1991-10-01&rft.volume=57&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-30 N1 - Date created - 1991-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extreme hyperkalemia induced by drugs. AN - 72149715; 1924001 AB - Because of age and disease-induced pathophysiologic changes, elderly and diabetic patients are prone to hyperkalemia under even the best of circumstances. Further complicating the situation is the fact that the drugs often prescribed for these populations can affect potassium homeostasis. Drs Rigolin and Chap describe a case in which an elderly diabetic man with azotemia survived extreme drug-induced hyperkalemia. JF - Postgraduate medicine AU - Rigolin, V H AU - Chap, L AD - Northwestern University Medical School/Veterans Administration Lakeside Medical Center, Chicago. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 129 EP - 131 VL - 90 IS - 5 SN - 0032-5481, 0032-5481 KW - Diuretics KW - 0 KW - Insulin KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Diuretics -- adverse effects KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Humans KW - Diabetes Mellitus, Type 2 -- complications KW - Aged KW - Diabetes Mellitus, Type 2 -- metabolism KW - Potassium -- administration & dosage KW - Potassium -- metabolism KW - Male KW - Insulin -- adverse effects KW - Hyperkalemia -- therapy KW - Hyperkalemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72149715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Extreme+hyperkalemia+induced+by+drugs.&rft.au=Rigolin%2C+V+H%3BChap%2C+L&rft.aulast=Rigolin&rft.aufirst=V&rft.date=1991-10-01&rft.volume=90&rft.issue=5&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Murine peritoneal macrophage gangliosides inhibit lymphocyte proliferation. AN - 72137156; 1919364 AB - Gangliosides have been shown to act as immunoregulatory agents by altering proliferative responses of lymphocytes to both antigens and mitogens. Most early studies have utilized brain gangliosides and have required high concentrations. The role of endogenous gangliosides from macrophages has remained unexplored. In this study, thioglycolate-elicited murine peritoneal macrophage gangliosides were purified and added to cultures of murine lymphocytes. Nanogram amounts caused a profound inhibition of LPS-induced DNA synthesis of splenocytes and of purified B lymphocytes, without demonstrable cellular toxicity. No effect was seen using asialo-GM1. This effect was present across a wide range of lipopolysaccharide (LPS) doses. Nanogram amounts of macrophage gangliosides also inhibited concanavalin A (ConA)-mediated lymphocyte proliferation. Inhibition of LPS-induced mitogenesis was present even if gangliosides were removed from the extracellular environment after 15-60 min of incubation prior to the addition of LPS. This inhibition was reversible with incubation of ganglioside pre-treated lymphocytes in medium containing serum. These inhibitory properties of macrophage gangliosides are distinct from those found in studies using brain gangliosides, and support a potential role for macrophage gangliosides as negative modulators of lymphocyte proliferation. JF - Journal of leukocyte biology AU - Berenson, C S AU - Ryan, J L AD - Infectious Disease Section, West Haven Veterans Administration Medical Center, Connecticut. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 393 EP - 401 VL - 50 IS - 4 SN - 0741-5400, 0741-5400 KW - Gangliosides KW - 0 KW - Lipopolysaccharides KW - Concanavalin A KW - 11028-71-0 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice KW - Female KW - Macrophages -- cytology KW - Lymphocyte Activation -- drug effects KW - Gangliosides -- analysis KW - Peritoneal Cavity -- cytology KW - Macrophages -- chemistry KW - Gangliosides -- pharmacology KW - Macrophages -- metabolism KW - Gangliosides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72137156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Murine+peritoneal+macrophage+gangliosides+inhibit+lymphocyte+proliferation.&rft.au=Berenson%2C+C+S%3BRyan%2C+J+L&rft.aulast=Berenson&rft.aufirst=C&rft.date=1991-10-01&rft.volume=50&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. The VA Cooperative Study Group (No. 119) AN - 72134156; 1655605 AB - Patients with overt alcoholic liver disease who had participated in a multicenter therapeutic trial and subgroups of controls (i.e., alcoholic patients without liver disease and patients with neither alcoholism nor liver disease) were tested for hepatitis B virus and hepatitis C virus antibodies to determine the prevalence of these antibodies to determine the prevalence of these antibodies and any clinical association in the progression and outcome of alcoholic liver disease. Antibodies to hepatitis B (anti-HBs and/or anti-HBc) were found in 29.2% of patients with alcoholic liver disease, in 26.1% of hospitalized alcoholic patients without liver disease and in 24.2% of hospitalized nonalcoholic patients without liver disease; frequencies were not significantly different from one another. HBsAg was not evaluated because HBsAg+ patients had been excluded from the original trial. The presence of these antibody markers correlated with ethnic origin of and immunoglobulin levels in the patients. In contrast, antibody to hepatitis C, as detected by enzyme immunoassay, was positive in 27.1%, 4.8% and 3.0% of the three groups, respectively, the first differing significantly from the other two. Antibody to hepatitis C virus positivity correlated significantly with clinical severity of the disease and with the presence of histological features that imply chronic viral infection (periportal inflammation, cirrhosis), despite the fact that the supplementary assay for antibody to hepatitis C virus, using recombinant immunoblot assay, reduced the positive rate by 79%.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Mendenhall, C L AU - Seeff, L AU - Diehl, A M AU - Ghosn, S J AU - French, S W AU - Gartside, P S AU - Rouster, S D AU - Buskell-Bales, Z AU - Grossman, C J AU - Roselle, G A AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 581 EP - 589 VL - 14 IS - 4 Pt 1 SN - 0270-9139, 0270-9139 KW - Antibodies, Viral KW - 0 KW - Hepatitis B Antibodies KW - Index Medicus KW - Regression Analysis KW - Immunoblotting KW - Humans KW - Adult KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Survival Analysis KW - Liver Cirrhosis, Alcoholic -- immunology KW - Hepatitis, Alcoholic -- immunology KW - Hepacivirus -- immunology KW - Hepatitis, Alcoholic -- mortality KW - Liver Cirrhosis, Alcoholic -- mortality KW - Hepatitis B Antibodies -- analysis KW - Antibodies, Viral -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72134156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Antibodies+to+hepatitis+B+virus+and+hepatitis+C+virus+in+alcoholic+hepatitis+and+cirrhosis%3A+their+prevalence+and+clinical+relevance.+The+VA+Cooperative+Study+Group+%28No.+119%29&rft.au=Mendenhall%2C+C+L%3BSeeff%2C+L%3BDiehl%2C+A+M%3BGhosn%2C+S+J%3BFrench%2C+S+W%3BGartside%2C+P+S%3BRouster%2C+S+D%3BBuskell-Bales%2C+Z%3BGrossman%2C+C+J%3BRoselle%2C+G+A&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1991-10-01&rft.volume=14&rft.issue=4+Pt+1&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 1991 Oct;14(4 Pt 1):730-3 [1655608] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. AN - 72118372; 1910817 AB - Cadmium exposure is capable of causing acute and chronic lung injuries, but the specific pathogenetic mechanisms are uncertain. The effects of cadmium ion (Cd2+) on phospholipid metabolism were examined in cultured bovine pulmonary artery endothelial cells (BPAEC), as endothelial cells appear to be particularly vulnerable to the toxic effects of this metallic ion. Exposure of radiolabeled BPAEC to millimolar concentrations of Cd2+ causes liberation of substantial amounts of [3H]arachidonic acid ([3H]AA), but only small amounts of [14C]stearic acid, from each of the major phospholipid subclasses. Analyses of hydrolytic products in BPAEC radiolabeled with [3H]myo-inositol and exposed to Cd2+ indicate that degradation of complex phospholipids is mediated by phospholipase A2. The ability of BPAEC to incorporate fatty acids or lysophosphatides into complex phospholipids is similarly impaired after exposure to Cd2+, suggesting that the liberation of [3H]AA might be due to impairment of reacylation mechanisms and not to increased hydrolytic activity of phospholipase A2. Of the two enzymes involved in reacylation reactions, Cd2+ is found to inhibit the activity of arachidonyl-specific acyl coenzyme A synthetase but not the activity of acyltransferase. Cd2+ also causes a profound time- and dose-dependent depletion of adenosine triphosphate levels in BPAEC, and these changes closely correlate with the liberation of [3H]AA. We suggest that impairment of reacylation mechanisms, and the consequent accumulation of arachidonic acid, may be important in the development of the acute inflammatory reaction that is characteristic of Cd(2+)-induced lung injury. JF - American journal of respiratory cell and molecular biology AU - Nelson, J M AU - Duane, P G AU - Rice, K L AU - Niewoehner, D E AD - Pulmonary Section-111N, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 328 EP - 336 VL - 5 IS - 4 SN - 1044-1549, 1044-1549 KW - Cations, Divalent KW - 0 KW - Fatty Acids, Nonesterified KW - Lysophosphatidylcholines KW - Phospholipids KW - Stearic Acids KW - Cadmium KW - 00BH33GNGH KW - Arachidonic Acid KW - 27YG812J1I KW - stearic acid KW - 4ELV7Z65AP KW - Inositol KW - 4L6452S749 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Animals KW - Inositol -- metabolism KW - Arachidonic Acid -- metabolism KW - Chromatography, High Pressure Liquid KW - Cattle KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Adenosine Triphosphate -- metabolism KW - Lysophosphatidylcholines -- metabolism KW - Stearic Acids -- metabolism KW - Fatty Acids, Nonesterified -- metabolism KW - Phospholipases A -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Phospholipids -- metabolism KW - Cadmium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Cadmium+ion-induced+alterations+of+phospholipid+metabolism+in+endothelial+cells.&rft.au=Nelson%2C+J+M%3BDuane%2C+P+G%3BRice%2C+K+L%3BNiewoehner%2C+D+E&rft.aulast=Nelson&rft.aufirst=J&rft.date=1991-10-01&rft.volume=5&rft.issue=4&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-15 N1 - Date created - 1991-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trajectories of Health: In Concept and Empirical Pattern AN - 61313825; 9400343 AB - A model is presented of physical & emotional health trajectories over the approximately 45 years of adult life, based on data from the oldest longitudinal study still active in the US (initiated by L. M. Terman, 1925) on 857 men, identifying broad patterns of stability & change in health 1940-1986. Qualitative data analysis is used to describe trajectories characteristics of most individuals, & quantitative analysis to differentiate these patterns using individual & medical characteristics. The value of this approach to measure health longitudinally involves a focus on the sequence of health transitions in lives. 4 Tables, 1 Figure, 43 References. Adapted from the source document. JF - Behavior, Health, and Aging AU - Clipp, Elizabeth Colerick AU - Pavalko, Eliza K AU - Elder, Glen H, Jr AD - Veterans Administration Medical Center, Durham NC 27705 Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 159 EP - 179 VL - 2 IS - 3 SN - 1049-085X, 1049-085X KW - health trajectories, longitudinal analysis KW - 1940-1986 qualitative/quantitative data KW - men, US KW - Life Cycle KW - Males KW - Health Problems KW - United States of America KW - Health KW - Adults KW - article KW - 0394: social psychology; life cycle & biography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61313825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior%2C+Health%2C+and+Aging&rft.atitle=Trajectories+of+Health%3A+In+Concept+and+Empirical+Pattern&rft.au=Clipp%2C+Elizabeth+Colerick%3BPavalko%2C+Eliza+K%3BElder%2C+Glen+H%2C+Jr&rft.aulast=Clipp&rft.aufirst=Elizabeth&rft.date=1991-10-01&rft.volume=2&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Behavior%2C+Health%2C+and+Aging&rft.issn=1049085X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - BHAGEG N1 - SubjectsTermNotLitGenreText - Health; Adults; Health Problems; Life Cycle; United States of America; Males ER - TY - JOUR T1 - Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections. AN - 72161401; 1656740 AB - This was a randomized, third-party-blinded, multicenter study that compared once-daily azithromycin (500 mg on day 1, followed by 250 mg on days 2-5) to cefaclor (500 mg three times daily for 10 days) in the treatment of patients with acute bronchitis or pneumonia. A total of 546 patients were entered into the study and 272 patients were evaluable for efficacy analysis. Of these, 249 (176 azithromycin, 73 cefaclor) had bronchitis and 23 (15 azithromycin, 8 cefaclor) had pneumonia. The combined clinical cure and improvement rate, as determined by the investigator, was 96% for azithromycin and 94% for cefaclor, with 88% bacteriologic eradication in both treatment groups. The elimination of Haemophilus influenzae was significantly better with azithromycin (94.5%) than with cefaclor (61.1%) (p less than 0.001; Fisher's exact two-tail test). The two antibiotics were well tolerated during this study; the incidence of side effects reported was similar for azithromycin and cefaclor. Approximately two thirds of the side effects were mild. Only minor abnormalities in the screening laboratory tests were noted. This study shows that a 5-day course of once-daily azithromycin is as effective as a 10-day three times daily course of cefaclor in the treatment of patients with acute lower respiratory tract infections. JF - The American journal of medicine AU - Dark, D AD - Veterans Administration Medical Center, Medical Services Office, Kansas City, Missouri 64128. Y1 - 1991/09/12/ PY - 1991 DA - 1991 Sep 12 SP - 31S EP - 35S VL - 91 IS - 3A SN - 0002-9343, 0002-9343 KW - Erythromycin KW - 63937KV33D KW - Cefaclor KW - 69K7K19H4L KW - Azithromycin KW - 83905-01-5 KW - Abridged Index Medicus KW - Index Medicus KW - Moraxella (Branhamella) catarrhalis KW - Staphylococcal Infections -- drug therapy KW - Neisseriaceae Infections -- drug therapy KW - Sputum -- microbiology KW - Prospective Studies KW - Klebsiella Infections -- drug therapy KW - Humans KW - Haemophilus Infections -- drug therapy KW - Streptococcal Infections -- drug therapy KW - Bronchitis -- drug therapy KW - Pneumonia -- microbiology KW - Erythromycin -- analogs & derivatives KW - Cefaclor -- therapeutic use KW - Erythromycin -- therapeutic use KW - Erythromycin -- adverse effects KW - Bronchitis -- microbiology KW - Pneumonia -- drug therapy KW - Cefaclor -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72161401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Multicenter+evaluation+of+azithromycin+and+cefaclor+in+acute+lower+respiratory+tract+infections.&rft.au=Dark%2C+D&rft.aulast=Dark&rft.aufirst=D&rft.date=1991-09-12&rft.volume=91&rft.issue=3A&rft.spage=31S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-20 N1 - Date created - 1991-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of alterations in mental activity on the breathing pattern in healthy subjects. AN - 85244631; pmid-1892283 AB - The overall output from the respiratory centers is regulated by an automatic metabolic control system in the brainstem and by higher neural centers under direct voluntary control. An understanding of the constancy with which respiration is controlled can be obtained by measuring the breath-to-breath variability in breathing pattern. We hypothesized that different forms of mental activity would alter the variability of breathing pattern. To test this hypothesis, we measured breathing pattern on a breath-by-breath basis during resting wakefulness and during four conditions of altered mental activity. Measurements were obtained with a calibrated respiratory inductive plethysmograph, and variability was assessed by calculations of the coefficients of variation. We also examined the effect of the altered states of mental activity on the mean values of the breathing pattern components. We found that noxious stimulation increased the variability of all the breathing pattern indices, audiovisual stimulation tended to increase the variability of tidal volume (VT), and mental arithmetic had no effect. In addition, the variability of breathing pattern was increased during rapid eye movement sleep and decreased during Stage IV sleep. The variability of VT and expiratory time were greater than that of inspiratory time (TI) across the different states of mental activity. Significant correlations were observed between VT and TI and between VT and frequency (f) during Stage IV sleep. With regards to the mean values, mental arithmetic, audiovisual stimulation, and noxious stimulation all increased minute ventilation and mean inspiratory flow.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American Review of Respiratory Disease AU - Mador, M J AU - Tobin, M J AD - Division of Pulmonary Medicine, State University of New York, Veterans Administration Medical Center, Buffalo 14215. PY - 1991 SP - 481 EP - 487 VL - 144 IS - 3 Pt 1 SN - 0003-0805, 0003-0805 KW - Human KW - Respiration KW - Cognition KW - Mathematics KW - Sleep, REM KW - Photic Stimulation KW - Sleep Stages KW - Mental Processes KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Plethysmography KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Review+of+Respiratory+Disease&rft.atitle=Effect+of+alterations+in+mental+activity+on+the+breathing+pattern+in+healthy+subjects.&rft.au=Mador%2C+M+J%3BTobin%2C+M+J&rft.aulast=Mador&rft.aufirst=M&rft.date=1991-09-01&rft.volume=144&rft.issue=3+Pt+1&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+American+Review+of+Respiratory+Disease&rft.issn=00030805&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visual detectability gradients: effect of illiteracy. AN - 85210710; pmid-1781980 AB - When subjects are required to detect a target pattern presented simultaneously with a number of similar non-target patterns in a brief exposure, marked differences of target detectability are observed as a function of the spatial location of the target (Efron, Yund, & Nichols, 1987, 1990a, b, c; Yund, Efron & Nichols, 1990a, b, c). These differences in detectability as a function of retinal locus, referred to collectively as a "detectability gradient," have been attributed to a central serial processing mechanism, which scans the decaying neural representation of the image. There also is evidence suggesting that, at least in some circumstances, this gradient may be influenced by the direction in which subjects normally read (Heron, 1957; Mishkin & Forgays, 1952; Efron et al., 1987). The object of the present experiment was to determine whether the detectability gradient obtained with the non-linguistic stimuli used in our previous experiments would differ as a function of previous reading experience. The experiment was performed on a group of 60 illiterate subjects and on a socioeconomic-matched group of 60 literate subjects. While the overall accuracy of target detection was identical in the two groups, there were significant differences between the detectability gradients of the literate and illiterate subjects. The nature of these differences indicates that reading, or learning to read, causes the scanning mechanisms of literate subjects to adopt more consistent scan paths, from subject to subject, than they would have adopted without this reading experience. JF - Brain and Cognition AU - Ostrosky-Solis, F AU - Efron, R AU - Yund, E W AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1991 SP - 42 EP - 51 VL - 17 IS - 1 SN - 0278-2626, 0278-2626 KW - Analysis of Variance KW - Orientation KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Attention KW - Female KW - Male KW - Educational Status KW - Pattern Recognition, Visual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85210710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Visual+detectability+gradients%3A+effect+of+illiteracy.&rft.au=Ostrosky-Solis%2C+F%3BEfron%2C+R%3BYund%2C+E+W&rft.aulast=Ostrosky-Solis&rft.aufirst=F&rft.date=1991-09-01&rft.volume=17&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visual detectability gradients: effect of high-speed visual experience. AN - 85208049; pmid-1781981 AB - The detectability of a target pattern presented briefly with a number of similar nontarget patterns varies as a function of the spatial location of the target. Previous work attributes these detectability gradients to a visual search process--a non-eye movement serial scan--that examines a decaying neural representation of the image. (Heron, 1957; Efron, Yund, & Nichols, 1987, 1990a,b,c; Yund, Efron, & Nichols, 1990a,b,c). The results reported in the companion paper (Ostrosky-Solis, Efron, & Yund, 1991) indicated that literacy did not affect overall performance levels but did influence scanning behavior: "...reading, or learning to read, caused the scanning mechanisms of literate subjects to adopt more consistent scan paths, from subject to subject, than they would have adopted without this reading experience." The purpose of the present experiment was to determine the effect on this scanning mechanism, if any, of an entirely different type of visual experience--the high-speed visual processing required of tennis players. Unlike reading which requires the linguistic interpretation of a highly structured visual input, tennis skill requires rapid target detection and tracking in three-dimensional visual space as well as large scale visual-motor coordination. As in the previous experiments, subjects were required to detect a vertical stripe pattern among a number of similar non-target patterns. The experiment was performed on a group of 52 tennis players and on an age- and sex-matched group of 52 non-tennis players. The overall accuracy of target detection was greater among the tennis players than among the non-tennis players and, of more interest, there was a significant difference in the detectability gradients. The detection advantage of the tennis group seemed to reach its maximum in the first half of the scan and then to deteriorate as the scan proceeded. These results indicate that visual experience other than reading can affect the habitual activity of the scanning mechanism. JF - Brain and Cognition AU - Buckles, K M AU - Yund, E W AU - Efron, R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1991 SP - 52 EP - 63 VL - 17 IS - 1 SN - 0278-2626, 0278-2626 KW - Analysis of Variance KW - Orientation KW - Human KW - Motor Skills KW - Tennis KW - Pattern Recognition, Visual KW - Adult KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Attention KW - Time Factors KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Visual+detectability+gradients%3A+effect+of+high-speed+visual+experience.&rft.au=Buckles%2C+K+M%3BYund%2C+E+W%3BEfron%2C+R&rft.aulast=Buckles&rft.aufirst=K&rft.date=1991-09-01&rft.volume=17&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Psychiatric heterogeneity in antisocial alcoholics: relation to familial alcoholism. AN - 72504748; 1743013 AB - There is some indication that addicts who qualify for a diagnosis of antisocial personality disorder (ASP) do not comprise a homogeneous group with respect to psychopathology. This preliminary study attempted to determine the extent to which DSM-III diagnosed ASP alcoholics with alcoholism on both sides of their family could be differentiated with respect to childhood behavioral problems and additional adult psychopathology from ASP alcoholics with low degrees of familial alcoholism. Two groups of ASP alcoholic patients were compared: (1) 11 high familial (bilineal) alcoholics, and (2) 22 low familial (nonfamilial or unilineal) alcoholics. Few group differences were found in sociodemographic or alcohol-related characteristics, although the high familial group tended to be younger. However, the high familial alcoholism group tended to report more childhood antisocial behaviors and more childhood behavior problems overall. The high familial alcoholism group also reported more psychopathology on three of the 10 Minnesota Multiphasic Personality Inventory (MMPI) clinical scales, paranoia (P less than .05), schizophrenia (P less than .06), and masculine-feminine (P less than .025). Effect sizes for these three variables were in the moderate range. The group MMPI profile of the high familial alcoholism group was indicative of serious characterological disturbances, while that of the low familial alcoholism group was much more normal. The results of this preliminary study provided evidence suggesting that antisocial individuals with a high degree of familial alcoholism are more likely to manifest psychopathology than antisocial individuals with a lesser degree of familial alcoholism. JF - Comprehensive psychiatry AU - Alterman, A I AU - Gerstley, L J AU - Strohmetz, D B AU - McKay, J R AD - Veterans Administration Medical Center, Philadelphia, PA 19104. PY - 1991 SP - 423 EP - 430 VL - 32 IS - 5 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Personality Inventory -- statistics & numerical data KW - Risk Factors KW - Humans KW - Adult KW - Personality Development KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Personality Assessment -- statistics & numerical data KW - Antisocial Personality Disorder -- genetics KW - Antisocial Personality Disorder -- rehabilitation KW - Antisocial Personality Disorder -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72504748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Psychiatric+heterogeneity+in+antisocial+alcoholics%3A+relation+to+familial+alcoholism.&rft.au=Alterman%2C+A+I%3BGerstley%2C+L+J%3BStrohmetz%2C+D+B%3BMcKay%2C+J+R&rft.aulast=Alterman&rft.aufirst=A&rft.date=1991-09-01&rft.volume=32&rft.issue=5&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse. AN - 72096259; 1890839 AB - There is ample evidence to suggest that hematogenous metastasis may be related to the ability of tumor cells to promote aggregation of host platelets. Arachidonic acid metabolism in platelets and vessel walls may also contribute to the metastatic process. Several preliminary trials of platelet inhibitory agents have been performed. Ketoconazole (inhibitor of lipoxygenase and thromboxane synthetase), verapamil (calcium antagonist), forskolin (stimulator of platelet adenylate cyclase), and indomethacin (inhibitor of cyclooxygenase) were examined, alone and in combination, to investigate their effects on platelet aggregation and on hepatic metastases from human pancreatic tumor cells (RWP-2) in nude mice. The tumor cells were injected intrasplenically, and the animals were divided into control, single-drug and combination treatment groups. The agents were administered intraperitoneally 1 hr before and every 24 hr after the tumor cell injections for 6 days. Statistically significant differences were observed between the control and single-treatment groups on the reduction of liver tumor nodules (range P less than 0.001-0.032) and in the liver surface areas occupied by tumor (range P less than 0.001-0.013). Furthermore, when these agents were combined, similar reductions in liver tumor nodules were noted (range P less than 0.001-0.008), while even greater inhibitory effects were seen in the liver surface areas occupied by tumor (P less than 0.001) compared with the single-treatment groups. Also, the combination studies strongly inhibited RWP-2-induced platelet aggregation in human platelet-rich plasma. JF - Journal of surgical oncology AU - Tzanakakis, G N AU - Agarwal, K C AU - Veronikis, D K AU - Vezeridis, M P AD - Surgical Service, Veterans Administration Medical Center, Providence, RI 02908. Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 45 EP - 50 VL - 48 IS - 1 SN - 0022-4790, 0022-4790 KW - Platelet Aggregation Inhibitors KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - Verapamil KW - CJ0O37KU29 KW - Ketoconazole KW - R9400W927I KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Drug Interactions KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Mice, Nude KW - Mice KW - Verapamil -- pharmacology KW - Ketoconazole -- pharmacology KW - Indomethacin -- pharmacology KW - Pancreatic Neoplasms -- pathology KW - Adenocarcinoma -- secondary KW - Platelet Aggregation Inhibitors -- pharmacology KW - Liver Neoplasms -- secondary KW - Platelet Aggregation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72096259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Effects+of+antiplatelet+agents+alone+or+in+combinations+on+platelet+aggregation+and+on+liver+metastases+from+a+human+pancreatic+adenocarcinoma+in+the+nude+mouse.&rft.au=Tzanakakis%2C+G+N%3BAgarwal%2C+K+C%3BVeronikis%2C+D+K%3BVezeridis%2C+M+P&rft.aulast=Tzanakakis&rft.aufirst=G&rft.date=1991-09-01&rft.volume=48&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-16 N1 - Date created - 1991-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Screening for colon malignancy with colonoscopy. AN - 85224306; pmid-1858758 AB - Screening of asymptomatic individuals for colon malignancy has been advocated for the past 20 yr in the hopes of reducing colon cancer mortality. Although sigmoidoscopy is an important element of current screening recommendations, the sensitivity of this test in asymptomatic subjects has never been studied. The purpose of this study was to determine the prevalence and location of polyps and cancers in an asymptomatic population by performing full colonoscopy. We wished to assess the sensitivity of screening flexible sigmoidoscopy to 60 cm by determining how many patients with adenomas or cancer had "index" adenomatous polyps in the distal 60 cm. One hundred five healthy male outpatients, over 50 yr old, with negative examinations for occult blood in stools and no prior history of colon pathology, had full colonoscopy. Careful examination of the distal 60 cm was performed, followed by a full colon examination to the cecum. Forty-three patients (41%) had adenomatous polyps, and only 19 of these patients had an index adenomatous polyp in the distal 60 cm. Therefore, the sensitivity of sigmoidoscopy was 44%. The prevalence of adenomas increased with age. Patients were assigned to one of three groups based on the findings in the distal 60 cm. Group 1 (n = 65) had no polyps in the distal 60 cm, but 18 of these patients (28%) had adenomatous polyps in the proximal colon. Among 21 patients with only hyperplastic polyps in the distal 60 cm (group 2), six patients (29%) had proximal adenomas. In group 3, eight of 19 patients (42%) with adenomas in the distal 60 cm also had proximal adenomatous polyps. We conclude that adenomatous polyps are common in asymptomatic men who have negative tests for fecal occult blood. Sigmoidoscopy to 60 cm had a sensitivity of only 44% in this patient population, suggesting that this is an insensitive test for the detection of patients with adenomatous polyps. JF - The American Journal of Gastroenterology AU - Lieberman, D A AU - Smith, F W AD - Veterans Administration Medical Center, Portland, Oregon. PY - 1991 SP - 946 EP - 951 VL - 86 IS - 8 SN - 0002-9270, 0002-9270 KW - Mass Screening KW - Human KW - Risk Factors KW - Colonic Polyps KW - Aged KW - Middle Age KW - Male KW - Prevalence KW - Sigmoidoscopy KW - Colonoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Screening+for+colon+malignancy+with+colonoscopy.&rft.au=Lieberman%2C+D+A%3BSmith%2C+F+W&rft.aulast=Lieberman&rft.aufirst=D&rft.date=1991-08-01&rft.volume=86&rft.issue=8&rft.spage=946&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog. AN - 80736574; 1867522 AB - The efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in each group received lovastatin, and the remaining six received only distilled water. All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterol-fed/lovastatin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease. JF - Annals of surgery AU - Saunders, K D AU - Cates, J A AU - Abedin, M Z AU - Rege, S AU - Festekdjian, S F AU - Howard, W AU - Roslyn, J J AD - Research and Surgical Services, Sepulveda Veterans Administration Medical Center, California. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 149 EP - 154 VL - 214 IS - 2 SN - 0003-4932, 0003-4932 KW - Cholesterol, Dietary KW - 0 KW - Cholesterol, HDL KW - Cholesterol, LDL KW - Cholesterol KW - 97C5T2UQ7J KW - Lovastatin KW - 9LHU78OQFD KW - Abridged Index Medicus KW - Index Medicus KW - Cholesterol, LDL -- blood KW - Animals KW - Sciuridae KW - Gallbladder -- metabolism KW - Cholesterol, HDL -- blood KW - Liver -- metabolism KW - Cholesterol -- analysis KW - Bile -- metabolism KW - Cholesterol, Dietary -- adverse effects KW - Male KW - Cholelithiasis -- chemistry KW - Cholelithiasis -- chemically induced KW - Lovastatin -- pharmacology KW - Cholelithiasis -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80736574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgery&rft.atitle=Lovastatin+inhibits+gallstone+formation+in+the+cholesterol-fed+prairie+dog.&rft.au=Saunders%2C+K+D%3BCates%2C+J+A%3BAbedin%2C+M+Z%3BRege%2C+S%3BFestekdjian%2C+S+F%3BHoward%2C+W%3BRoslyn%2C+J+J&rft.aulast=Saunders&rft.aufirst=K&rft.date=1991-08-01&rft.volume=214&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgery&rft.issn=00034932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-12 N1 - Date created - 1991-09-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1972 Jun;51(6):1495-503 [5063380] Am J Clin Pathol. 1966 Mar;45(3):290-6 [5932858] Gastroenterology. 1974 May;66(5):1036-45 [4826988] J Lipid Res. 1978 Nov;19(8):945-55 [731129] Lab Anim Sci. 1978 Aug;28(4):428-32 [100653] Gastroenterology. 1980 Jun;78(6):1412-8 [7372061] Hepatology. 1982 Nov-Dec;2(6):804-10 [7141392] Ann Intern Med. 1981 Sep;95(3):257-82 [7023307] J Lipid Res. 1983 Apr;24(4):461-8 [6854153] Gastroenterology. 1990 Jun;98(6):1572-6 [2338194] J Clin Invest. 1985 Nov;76(5):1773-81 [4056052] Pharmacotherapy. 1987;7(6):198-210 [3328165] N Engl J Med. 1988 Feb 18;318(7):393-7 [3340116] Ann Intern Med. 1987 Nov;107(5):609-15 [3662274] Hepatology. 1988 Sep-Oct;8(5):1147-50 [3047037] Ann Surg. 1988 Sep;208(3):274-8 [3421753] J Biol Chem. 1957 Mar;225(1):177-83 [13416228] J Biochem. 1964 Nov;56:424-31 [14235501] J Clin Invest. 1968 May;47(5):1043-52 [5645851] Gastroenterology. 1974 Apr;66(4):565-73 [4821079] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression. AN - 80729820; 1867323 AB - Cultured glomerular mesangial cells (MC) respond to low concentrations of bacterial endotoxin (ET) by secreting prostaglandins and interleukin-1. To evaluate further the nature of ET-induced mesangial cell activation, the authors evaluated the effects of this agent on MC morphology and cytoskeletal organization. Bacterial ET, in concentrations as low as I ng/ml, induced reversible membrane ruffling, cellular rounding, and extension of many filopodia and lamellopodia. Augmented fluid-phase pinocytosis occurred in parallel, as determined by transmission electron microscopy and tritiated sucrose uptake. These cellular morphologic and functional changes were associated with an extensive, but reversible, depolymerization of actin microfilaments. Actin gene expression was also modified by ET. At 4 to 6 hours after ET exposure, Northern blot analysis showed a twofold to fourfold increase in actin mRNA levels. In situ hybridizations of ET-stimulated cells at the light and electron microscopic levels demonstrated a markedly asymmetric distribution of actin mRNA, which was localized in the cellular periphery at filopodial and lamellopodial extensions, presumably sites of new actin protein synthesis. It is concluded that ET effects on MC are distinct from the nonspecific lytic or 'toxic' actions described for other cell types. Endotoxin induces a global activation of this cell type associated with major changes in membrane structure, cytoskeletal organization, and gene expression, which resemble in many respects the responses to peptide mitogens. JF - The American journal of pathology AU - Bursten, S L AU - Stevenson, F AU - Torrano, F AU - Lovett, D H AD - Department of Medicine, Seattle Veterans Administration Medical Center, Washington. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 371 EP - 382 VL - 139 IS - 2 SN - 0002-9440, 0002-9440 KW - Actins KW - 0 KW - Endotoxins KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Actins -- genetics KW - Pinocytosis -- drug effects KW - Male KW - Gene Expression -- drug effects KW - Glomerular Mesangium -- cytology KW - Glomerular Mesangium -- drug effects KW - Escherichia coli KW - Cytoskeleton -- ultrastructure KW - Cytoskeleton -- physiology KW - Endotoxins -- pharmacology KW - Cytoskeleton -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80729820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Mesangial+cell+activation+by+bacterial+endotoxin.+Induction+of+rapid+cytoskeletal+reorganization+and+gene+expression.&rft.au=Bursten%2C+S+L%3BStevenson%2C+F%3BTorrano%2C+F%3BLovett%2C+D+H&rft.aulast=Bursten&rft.aufirst=S&rft.date=1991-08-01&rft.volume=139&rft.issue=2&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-06 N1 - Date created - 1991-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 1963 Oct;43(4):555-78 [19971026] J Cell Biol. 1979 Oct;83(1):82-90 [315944] J Biol Chem. 1986 Dec 5;261(34):16141-7 [2946680] J Cell Biol. 1985 Apr;100(4):1031-40 [3920222] J Cell Biol. 1986 Mar;102(3):697-702 [3005336] J Clin Invest. 1988 Nov;82(5):1479-88 [3263392] Biochem J. 1987 Nov 1;247(3):613-9 [3122731] Am J Pathol. 1988 Dec;133(3):472-84 [3059803] Kidney Int. 1989 May;35(5):1111-8 [2549293] J Cell Biol. 1989 Jun;108(6):2343-53 [2738094] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7476-80 [6334309] Nature. 1984 Oct 4-10;311(5985):433-8 [6090941] Am J Pathol. 1986 Oct;125(1):130-40 [3535527] Kidney Int. 1986 Oct;30(4):474-80 [3537451] Proc Natl Acad Sci U S A. 1987 Jun;84(12):4122-5 [3473496] Anat Embryol (Berl). 1987;176(3):373-86 [3631536] Nature. 1986 Sep 11-17;323(6084):171-3 [3748188] Biochim Biophys Acta. 1985;780(3):197-212 [3896312] Kidney Int. 1990 May;37(5):1281-5 [2345426] Exp Cell Res. 1984 Jul;153(1):186-97 [6376151] J Cell Biol. 1984 May;98(5):1662-71 [6327718] J Cell Biol. 1980 Aug;86(2):634-40 [7400219] J Cell Biol. 1986 Sep;103(3):1021-31 [3017994] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bronchial epithelial cells release monocyte chemotactic activity in response to smoke and endotoxin. AN - 80715686; 1861084 AB - An increase in mononuclear phagocytes occurs within the airways during airway inflammation. Bronchial epithelial cells could release monocyte chemotactic activity and contribute to this increase. To test this hypothesis, bovine bronchial epithelial cells were isolated and maintained in culture. Bronchial epithelial cell culture supernatant fluids were evaluated for monocyte chemotactic activity. Epithelial cell culture supernatant fluids attracted significantly greater numbers of monocytes compared to media alone and the number of monocytes attracted increased in a time dependent manner. Endotoxin and smoke extract induced a dose and time dependent release of monocyte chemotactic activity compared with cells cultured in media (52.5 +/- 2.6 (endotoxin), 30.5 +/- 2.3 (smoke) vs 20.5 +/- 2.2 cells/high power field (HPF) p less than 0.001). The released activity was chemotactic by checkerboard analysis. Stimulation of the epithelial cells by opsonized zymosan, calcium ionophore (A23187), and PMA also resulted in an increase in monocyte chemotactic activity (p less than 0.01). Because the release of activity was blocked by the lipoxygenase inhibitors, nordihydroguaiaretic acid and diethycarbamazine, epithelial cell monolayers were cultured with 3 microCi [3H]arachidonic acid for 24 h and then exposed to A23187, PMA, or both stimuli, for 4, 8, and 24 h. Analysis of the released 3H activity was performed with reverse-phase HPLC and revealed that the major lipoxygenase product was leukotriene B4. These data suggest that monocytes may be recruited into airways in response to chemotactic factors released by bronchial epithelial cells. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Koyama, S AU - Rennard, S I AU - Leikauf, G D AU - Robbins, R A AD - Research Service, Omaha Veterans Administration Medical Center, NE. Y1 - 1991/08/01/ PY - 1991 DA - 1991 Aug 01 SP - 972 EP - 979 VL - 147 IS - 3 SN - 0022-1767, 0022-1767 KW - Chemotactic Factors KW - 0 KW - Endotoxins KW - Smoke KW - Calcimycin KW - 37H9VM9WZL KW - Masoprocol KW - 7BO8G1BYQU KW - Zymosan KW - 9010-72-4 KW - Cycloheximide KW - 98600C0908 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Diethylcarbamazine KW - V867Q8X3ZD KW - Hydrocortisone KW - WI4X0X7BPJ KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Zymosan -- pharmacology KW - Dose-Response Relationship, Drug KW - Calcimycin -- pharmacology KW - Chromatography, High Pressure Liquid KW - Indomethacin -- pharmacology KW - Hydrocortisone -- pharmacology KW - Cattle KW - Chromatography, Gel KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes KW - Diethylcarbamazine -- pharmacology KW - Masoprocol -- pharmacology KW - Smoke -- adverse effects KW - Chemotaxis, Leukocyte -- drug effects KW - Endotoxins -- adverse effects KW - Bronchi -- metabolism KW - Bronchi -- drug effects KW - Chemotactic Factors -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80715686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Bronchial+epithelial+cells+release+monocyte+chemotactic+activity+in+response+to+smoke+and+endotoxin.&rft.au=Koyama%2C+S%3BRennard%2C+S+I%3BLeikauf%2C+G+D%3BRobbins%2C+R+A&rft.aulast=Koyama&rft.aufirst=S&rft.date=1991-08-01&rft.volume=147&rft.issue=3&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative efficacy and safety of bepridil and diltiazem in chronic stable angina pectoris refractory to diltiazem. The Bepridil Collaborative Study Group. AN - 80710160; 1858672 AB - The efficacy and safety of bepridil hydrochloride (200 to 400 mg/day) were evaluated in patients with chronic stable angina refractory to maximal tolerated doses of diltiazem (median 360 mg/day) in a randomized, multicenter, double-blind, parallel study. Baseline diltiazem data were obtained during a 2-week period, after which 86 patients were randomized to bepridil (n = 46) or diltiazem (n = 40). Angina frequency, nitroglycerin consumption and ischemic manifestations induced by exercise treadmill testing were evaluated over 8 weeks. Bepridil significantly (p less than 0.05) increased time to angina onset, time to 1 and 2 mm of ST-segment depression, total exercise time and total work over baseline values. Changes in time to angina onset and time to 1 mm of ST-segment depression were significantly (p less than 0.05) greater for bepridil than for diltiazem. Angina frequency and nitroglycerin consumption did not differ significantly between groups. Compared with baseline, bepridil significantly (p less than 0.001) decreased heart rate (mean 4 beats/min) and prolonged QTc (mean 35 ms). The most frequent adverse effects in both groups were nausea, asthenia, dizziness, headache and diarrhea. Four patients taking bepridil and 1 taking diltiazem withdrew from the study because of adverse reactions. No sudden deaths, myocardial infarctions or instances of sustained ventricular tachycardia or torsades de pointes occurred in either group. The data indicate that bepridil provided safe and effective antianginal and antiischemic therapy in patients with chronic stable angina who exhibited less than optimal response to maximal tolerated doses of diltiazem. JF - The American journal of cardiology AU - Singh, B N AD - Department of Cardiology, Veterans Administration Medical Center of West Los Angeles, California. Y1 - 1991/08/01/ PY - 1991 DA - 1991 Aug 01 SP - 306 EP - 312 VL - 68 IS - 4 SN - 0002-9149, 0002-9149 KW - Bepridil KW - 755BO701MA KW - Diltiazem KW - EE92BBP03H KW - Abridged Index Medicus KW - Index Medicus KW - Drug Tolerance KW - Heart Rate -- drug effects KW - Exercise Test -- drug effects KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Diltiazem -- pharmacology KW - Bepridil -- pharmacology KW - Angina Pectoris -- drug therapy KW - Bepridil -- therapeutic use KW - Bepridil -- adverse effects KW - Diltiazem -- therapeutic use KW - Diltiazem -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80710160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Comparative+efficacy+and+safety+of+bepridil+and+diltiazem+in+chronic+stable+angina+pectoris+refractory+to+diltiazem.+The+Bepridil+Collaborative+Study+Group.&rft.au=Singh%2C+B+N&rft.aulast=Singh&rft.aufirst=B&rft.date=1991-08-01&rft.volume=68&rft.issue=4&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of lithium on function and growth of thyroid cells in vitro. AN - 80697319; 1649747 AB - Lithium has been reported to alter thyroid function and cause goiter in some patients. To explain the mechanism of lithium action in the thyroid gland, we studied the effect of lithium on thyroid function and cell growth in FRTL-5 rat thyroid cells and on de novo thyroid hormone formation in primary cultures of porcine thyroid follicles. TSH-induced iodide uptake was suppressed at 2 mM lithium in both FRTL-5 cells and porcine follicles. In porcine thyroid follicles, iodide uptake stimulated by 8-bromo-cAMP, iodine organification, and de novo thyroid hormone formation were also reduced by lithium; however, 2 mM lithium did not inhibit TSH-induced cAMP production. In FRTL-5 cells, lithium also inhibited forskolin-stimulated iodide uptake. These results suggested that lithium exerts its effect at a step involving cAMP signal transduction rather than inhibiting cAMP production. In both FRTL-5 thyroid cells and porcine follicles, lithium enhanced cell growth in basal states (lacking TSH) and with TSH treatment. In porcine thyroid cells, the protein kinase C activator, tetradecanoyl phorbol-13-acetate, increased cell growth, and lithium had an additive effect with tetradecanoyl phorbol-13-acetate on cell growth. To examine the possibility that the action of lithium was mediated by the protein kinase C pathway, porcine cells were incubated with lithium and H7, a selective protein kinase C inhibitor. Lithium-induced cell growth was suppressed to the basal level by H7. These results suggest that lithium exerts its growth-promoting effect through the protein kinase C system. JF - Endocrinology AU - Urabe, M AU - Hershman, J M AU - Pang, X P AU - Murakami, S AU - Sugawara, M AD - Endocrine Research Laboratory, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 807 EP - 814 VL - 129 IS - 2 SN - 0013-7227, 0013-7227 KW - Iodides KW - 0 KW - Isoquinolines KW - Piperazines KW - Triiodothyronine KW - 06LU7C9H1V KW - Colforsin KW - 1F7A44V6OU KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Thyrotropin KW - 9002-71-5 KW - Lithium KW - 9FN79X2M3F KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Cyclic AMP -- biosynthesis KW - Triiodothyronine -- physiology KW - Cell Division -- drug effects KW - Piperazines -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Rats KW - Protein Kinase C -- metabolism KW - Isoquinolines -- pharmacology KW - Colforsin -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Thyrotropin -- pharmacology KW - Iodides -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Thyroid Gland -- physiology KW - Thyroid Gland -- drug effects KW - Thyroid Gland -- cytology KW - Lithium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80697319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Effect+of+lithium+on+function+and+growth+of+thyroid+cells+in+vitro.&rft.au=Urabe%2C+M%3BHershman%2C+J+M%3BPang%2C+X+P%3BMurakami%2C+S%3BSugawara%2C+M&rft.aulast=Urabe&rft.aufirst=M&rft.date=1991-08-01&rft.volume=129&rft.issue=2&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of cyclophosphamide, doxorubicin, and vincristine with an alternating regimen of methotrexate, etoposide, and cisplatin/cyclophosphamide, doxorubicin, and vincristine in the treatment of extensive-disease small-cell lung carcinoma: a Mid-Atlantic Oncology Program study. AN - 80686798; 1649265 AB - An alternating regimen for the treatment of extensive-disease small-cell lung cancer (SCLC) was compared with standard treatment with cyclophosphamide, doxorubicin, and vincristine (CAV) in 170 patients. Overall severity of toxicity was similar in both arms, with four toxic deaths in each arm (4.7%). Response results were also similar, with 54% complete and partial responses with the standard regimen and 53% complete and partial responses with the alternating regimen. Median survival time was 6.9 months with the standard regimen and 9.2 months with the alternating regimen (P = .078). The 2-year survival rate was 1.2% for the standard regimen and 4.7% for the alternating regimen. Survival benefit for treatment with the alternating regimen reached statistical significance only in those subsets of patients with poorer prognosis (male sex, performance status 3, liver metastases, bone marrow metastases, and oat cell histologic subtype). JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Wampler, G L AU - Heim, W J AU - Ellison, N M AU - Ahlgren, J D AU - Fryer, J G AD - Richmond Veterans Administration Medical Center, VA. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 1438 EP - 1445 VL - 9 IS - 8 SN - 0732-183X, 0732-183X KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Prognosis KW - Doxorubicin -- administration & dosage KW - Cisplatin -- administration & dosage KW - Etoposide -- administration & dosage KW - Survival Rate KW - Middle Aged KW - Methotrexate -- administration & dosage KW - Female KW - Male KW - Proportional Hazards Models KW - Carcinoma, Small Cell -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80686798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Comparison+of+cyclophosphamide%2C+doxorubicin%2C+and+vincristine+with+an+alternating+regimen+of+methotrexate%2C+etoposide%2C+and+cisplatin%2Fcyclophosphamide%2C+doxorubicin%2C+and+vincristine+in+the+treatment+of+extensive-disease+small-cell+lung+carcinoma%3A+a+Mid-Atlantic+Oncology+Program+study.&rft.au=Wampler%2C+G+L%3BHeim%2C+W+J%3BEllison%2C+N+M%3BAhlgren%2C+J+D%3BFryer%2C+J+G&rft.aulast=Wampler&rft.aufirst=G&rft.date=1991-08-01&rft.volume=9&rft.issue=8&rft.spage=1438&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-22 N1 - Date created - 1991-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium antagonists and renal hemodynamics: implications for renal protection. AN - 72169979; 1932641 AB - During the past decade, attention has focused on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal effects. Calcium antagonists do not affect the vasodilated isolated perfused kidney, but they do dramatically alter the response of this preparation to vasoconstrictor agents. Our recent studies with the isolated perfused hydronephrotic rat kidney model, which permits visualization of afferent and efferent arterioles, have demonstrated that the augmentation of glomerular filtration rate observed in the isolated perfused kidney is attributable to preferential vasodilation of preglomerular vessels. Although the clinical implications of such observations have not been fully delineated, the results of recent studies indicate that calcium antagonists exert salutary effects on renal function in patients with impaired renal hemodynamics. Such disorders include radiocontrast-induced nephrotoxicity and transplant-associated acute renal insufficiency. It is apparent, however, that the effects of calcium antagonists on renal blood flow commend their use in the management of essential hypertension. JF - Journal of the American Society of Nephrology : JASN AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - S30 EP - S36 VL - 2 IS - 2 Suppl 1 SN - 1046-6673, 1046-6673 KW - Calcium Channel Blockers KW - 0 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Glomerular Filtration Rate KW - Hypertension, Renal -- prevention & control KW - Hypertension, Renal -- physiopathology KW - Humans KW - Disease Models, Animal KW - Kidney Diseases -- physiopathology KW - Calcium Channel Blockers -- pharmacology KW - Kidney Diseases -- prevention & control KW - Kidney -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72169979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Calcium+antagonists+and+renal+hemodynamics%3A+implications+for+renal+protection.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=1991-08-01&rft.volume=2&rft.issue=2+Suppl+1&rft.spage=S30&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Medical complications of spinal cord disease. AN - 72141142; 1921958 AB - Spinal cord injury increases the risk of many life-threatening medical problems, including respiratory failure, pulmonary embolism, and renal failure. Respiratory failure results from paralysis of muscles of inspiration (which impairs oxygen transport to alveoli) and of expiration (which impairs cough and predisposes to pneumonia and atelectasis). Respiratory failure in patients with spinal cord injury can be prevented by proper positioning of the patient, training of ventilatory muscles, pulmonary toilet, and aggressive use of antibiotics and bronchodilators. When respiratory failure occurs, it can be managed by administration of oxygen, intubation, and mechanical ventilation, and in instances of paralysis of the diaphragm, by diaphragmatic pacing. The risk of deep vein thrombosis and pulmonary embolism in acute spinal cord disease is increased by the immobilization of the patient and abnormalities in clotting factors. Thrombotic disease in spinal cord disease can be prevented by intermittent calf compression and heparinization. If pulmonary embolism develops, the patient should be started on a regimen of warfarin for at least 3 months. If anticoagulation is contraindicated, a Greenfield filter can be placed. However, concurrent use of quad cough places the patient at increased risk for complications from the Greenfield filter. Chronic pyelonephritis and systemic amyloidosis are the most common causes of renal failure in the patient with spinal cord disease. Renal failure can be prevented by maintaining a low postvoid residual volume, avoidance of indwelling catheters, use of medications that are not nephrotoxic, and rapid treatment of infection. Hemodialysis and peritoneal dialysis can extend the life of the patient with spinal cord disease in whom renal failure develops, and successful use of renal transplantation has recently been reported. JF - Neurologic clinics AU - Schmitt, J AU - Midha, M AU - McKenzie, N AD - Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA 23249. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 779 EP - 795 VL - 9 IS - 3 SN - 0733-8619, 0733-8619 KW - Index Medicus KW - Lung Diseases -- etiology KW - Humans KW - Kidney Diseases -- etiology KW - Vascular Diseases -- etiology KW - Spinal Cord Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72141142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurologic+clinics&rft.atitle=Medical+complications+of+spinal+cord+disease.&rft.au=Schmitt%2C+J%3BMidha%2C+M%3BMcKenzie%2C+N&rft.aulast=Schmitt&rft.aufirst=J&rft.date=1991-08-01&rft.volume=9&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Neurologic+clinics&rft.issn=07338619&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis. AN - 72063387; 1715446 AB - Proliferation of mesangial cells and expansion of mesangial matrix are common histologic features of proliferative glomerular disease, a frequent cause of renal failure. Proliferation of glomerular mesangial cells occurs in response to platelet-derived growth factor (PDGF), and these cells release PDGF and express PDGF A and B chain mRNAs. However, all studies relating PDGF to potential changes in glomerular structure and function to date have been performed in vitro. To explore the role of PDGF in proliferative glomerulonephritides, we studied the expression of PDGF in vivo in two animal models of IgA nephropathy with different histologic patterns of glomerular injury: either predominant mesangial proliferation or expansion of mesangial matrix. Increased expression of PDGF and PDGF B-chain mRNA in whole kidneys from diseased mice was demonstrated by immunohistochemical techniques and by solution hybridization assay, respectively. Immunohistochemically, PDGF was localized primarily within the mesangial area of glomeruli and to a much lower extent in interstitium. The increased PDGF expression correlated with the degree of hypercellularity and clinical features of the disease. In addition, PDGF expression was increased in some forms of human glomerulonephritis, characterized by mesangial proliferation. These findings suggest that PDGF may be a major contributor to mesangial cell proliferation seen in proliferative glomerulonephritides. JF - Laboratory investigation; a journal of technical methods and pathology AU - Gesualdo, L AU - Pinzani, M AU - Floriano, J J AU - Hassan, M O AU - Nagy, N U AU - Schena, F P AU - Emancipator, S N AU - Abboud, H E AD - Institute of Pathology, Veterans Administration Hospital, Case Western Reserve University, Cleveland, Ohio. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 160 EP - 167 VL - 65 IS - 2 SN - 0023-6837, 0023-6837 KW - Dextrans KW - 0 KW - Platelet-Derived Growth Factor KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Humans KW - RNA, Messenger -- analysis KW - Mice KW - Nucleic Acid Hybridization KW - Fluorescent Antibody Technique KW - Immunoenzyme Techniques KW - Platelet-Derived Growth Factor -- metabolism KW - Kidney -- metabolism KW - Kidney -- pathology KW - Glomerulonephritis, IGA -- metabolism KW - Glomerulonephritis, IGA -- chemically induced KW - Platelet-Derived Growth Factor -- genetics KW - Glomerulonephritis, IGA -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72063387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Platelet-derived+growth+factor+expression+in+mesangial+proliferative+glomerulonephritis.&rft.au=Gesualdo%2C+L%3BPinzani%2C+M%3BFloriano%2C+J+J%3BHassan%2C+M+O%3BNagy%2C+N+U%3BSchena%2C+F+P%3BEmancipator%2C+S+N%3BAbboud%2C+H+E&rft.aulast=Gesualdo&rft.aufirst=L&rft.date=1991-08-01&rft.volume=65&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-27 N1 - Date created - 1991-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of withdrawal of typical and atypical antipsychotic drugs: a case study. AN - 72030872; 1869497 AB - Haloperidol and clozapine were rapidly withdrawn from a schizophrenic patient on separate occasions several months apart. Mental status changes and fluctuations in involuntary movements were carefully observed under both conditions. Although little change in either mental status or involuntary movements was observed within the 3 weeks following the withdrawal of haloperidol, marked deterioration in mental status and involuntary movements occurred within 1 week of withdrawal of clozapine. Implications of this differential response to withdrawal of antipsychotic medications are discussed. JF - The Journal of clinical psychiatry AU - Alphs, L D AU - Lee, H S AD - Cleveland Veterans Administration Medical Center, Ohio 48101. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 346 EP - 348 VL - 52 IS - 8 SN - 0160-6689, 0160-6689 KW - Clozapine KW - J60AR2IKIC KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Acute Disease KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Humans KW - Adult KW - Schizophrenic Psychology KW - Psychoses, Substance-Induced -- psychology KW - Psychoses, Substance-Induced -- etiology KW - Male KW - Ambulatory Care KW - Haloperidol -- adverse effects KW - Haloperidol -- therapeutic use KW - Substance Withdrawal Syndrome -- etiology KW - Clozapine -- therapeutic use KW - Schizophrenia -- drug therapy KW - Schizophrenia -- chemically induced KW - Clozapine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72030872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Comparison+of+withdrawal+of+typical+and+atypical+antipsychotic+drugs%3A+a+case+study.&rft.au=Alphs%2C+L+D%3BLee%2C+H+S&rft.aulast=Alphs&rft.aufirst=L&rft.date=1991-08-01&rft.volume=52&rft.issue=8&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-19 N1 - Date created - 1991-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group. AN - 72112324; 1655072 AB - In order to determine the effect of an anticholinergic agent on mood and sleep, scopolamine (0.4 mg IM) was administered before bedtime for three consecutive nights to 10 depressed patients (8 with a history of alcohol abuse) and 10 normal comparison subjects. The patients had a small, statistically significant antidepressant response on the second morning of treatment. Scopolamine inhibited rapid eye movement (REM) sleep and prolonged REM latency equally in depressed patients and the normal comparison group. Partial tolerance to the REM inhibiting effect of scopolamine developed between the first and third night of treatment. A REM rebound occurred during recovery nights. These results are consistent with concepts relating central cholinergic mechanisms to the control of REM sleep. Compared with controls, patients showed a greater increase in Stage 2 and Stage 2% and a lesser and increase in Delta (Stage 3 and 4) sleep % and Stage 4% on the first night of treatment. Further, well-controlled studies are needed to determine whether anticholinergic drugs possess clinically significant antidepressant effects. JF - Biological psychiatry AU - Gillin, J C AU - Sutton, L AU - Ruiz, C AU - Darko, D AU - Golshan, S AU - Risch, S C AU - Janowsky, D AD - Department of Psychiatry, San Diego Veterans Administration Medical Center, CA. Y1 - 1991/07/15/ PY - 1991 DA - 1991 Jul 15 SP - 157 EP - 169 VL - 30 IS - 2 SN - 0006-3223, 0006-3223 KW - Receptors, Cholinergic KW - 0 KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Index Medicus KW - Receptors, Cholinergic -- drug effects KW - Personality Tests KW - Synaptic Transmission -- drug effects KW - Humans KW - Adult KW - Electroencephalography -- drug effects KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Reaction Time -- drug effects KW - Scopolamine Hydrobromide -- administration & dosage KW - Affect -- drug effects KW - Depressive Disorder -- psychology KW - Depressive Disorder -- drug therapy KW - Sleep Stages -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72112324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=The+effects+of+scopolamine+on+sleep+and+mood+in+depressed+patients+with+a+history+of+alcoholism+and+a+normal+comparison+group.&rft.au=Gillin%2C+J+C%3BSutton%2C+L%3BRuiz%2C+C%3BDarko%2C+D%3BGolshan%2C+S%3BRisch%2C+S+C%3BJanowsky%2C+D&rft.aulast=Gillin&rft.aufirst=J&rft.date=1991-07-15&rft.volume=30&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fulminant hepatic failure due to acute hepatitis B and delta co-infection: probable bloodborne transmission associated with a spring-loaded fingerstick device. AN - 85224137; pmid-2058635 AB - Fulminant hepatic failure (FHF) due to acute hepatitis B and delta co-infection occurred in a 74-yr-old female, who eventually died. There was no clear-cut epidemiology other than probable bloodborne transmission from a contaminated spring-loaded fingerstick device used for glucose determination, in an outpatient facility. This unusual mode of transmission reiterates the importance of using sterile cleansing and disposal procedures anytime there is a possibility of contamination with blood. JF - The American Journal of Gastroenterology AU - Mendez, L AU - Reddy, K R AU - Di Prima R A AU - Jeffers, L J AU - Schiff, E R AD - Veterans Administration Medical Center, Miami, Florida. PY - 1991 SP - 895 EP - 897 VL - 86 IS - 7 SN - 0002-9270, 0002-9270 KW - Hepatic Encephalopathy KW - Equipment Contamination KW - Human KW - Hepatitis B KW - Aged KW - Blood Specimen Collection KW - Case Report KW - Hepatitis D KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Fulminant+hepatic+failure+due+to+acute+hepatitis+B+and+delta+co-infection%3A+probable+bloodborne+transmission+associated+with+a+spring-loaded+fingerstick+device.&rft.au=Mendez%2C+L%3BReddy%2C+K+R%3BDi+Prima+R+A%3BJeffers%2C+L+J%3BSchiff%2C+E+R&rft.aulast=Mendez&rft.aufirst=L&rft.date=1991-07-01&rft.volume=86&rft.issue=7&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of reference microphone location and loudspeaker azimuth on probe tube microphone measurements. AN - 85148440; pmid-1768884 AB - The effects of loudspeaker azimuth and reference microphone location on probe tube microphone measures were assessed. The real ear unaided response (REUR), real ear aided response (REAR), and real ear insertion response (REIR) were obtained on a KEMAR. Aided measures were obtained with both a behind-the-ear and an in-the-ear hearing aid. All three measurements were affected by changes in the loudspeaker azimuth and reference microphone location. Responses obtained with a 90 degree loudspeaker azimuth or with the reference microphone located at-the-ear revealed greater disparity than those obtained under other conditions. Most of the differences occurred at frequencies above 2000 Hz, with measurements utilizing the behind-the-ear hearing aid showing greater dispersion. These results suggest that the location of the loudspeaker and the reference microphone are important variables when utilizing probe tube microphone measurements. JF - Journal of the American Academy of Audiology AU - Ickes, M A AU - Hawkins, David Broughton AU - Cooper, W A AD - Dorn Veterans Administration Medical Center, Columbia, SC 29201. PY - 1991 SP - 156 EP - 163 VL - 2 IS - 3 SN - 1050-0545, 1050-0545 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85148440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Effect+of+reference+microphone+location+and+loudspeaker+azimuth+on+probe+tube+microphone+measurements.&rft.au=Ickes%2C+M+A%3BHawkins%2C+David+Broughton%3BCooper%2C+W+A&rft.aulast=Ickes&rft.aufirst=M&rft.date=1991-07-01&rft.volume=2&rft.issue=3&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Anxiolytic activity of steroid anesthetic alphaxalone. AN - 80683109; 1677035 AB - The synthetic steroid anesthetic alphaxalone (3 alpha-hydroxy-5 alpha-pregnane-11,20-dione) was studied in two behavioral paradigms known to be sensitive to anxiolytic drugs. In an elevated plus maze, alphaxalone produced an anxiolytic profile, significantly increasing the percentage of entries made into the open arms as well as the percentage of time spent on the open arms. In the conflict test, alphaxalone (6 and 8 mg/kg) produced a significant dose-dependent increase in punished responding and a decrease (8 mg/kg) in unpunished responding. The pattern of responding was similar to that observed with the benzodiazepine agonist chlordiazepoxide (2-8 mg/kg). The increase in punished responding was not altered by the benzodiazepine antagonist Ro 15-1788 and only partially blocked by the picrotoxinin receptor ligand isopropylbicyclophospate (10 and 15 micrograms/kg). The gamma-aminobutyric acid agonists picrotoxin (1 mg/kg) and bicuculline (1 mg/kg) also failed to suppress the rate-increasing effects of alphaxalone in the conflict test. Chronic administration of alphaxalone for 1 week produced no tolerance to the anxiolytic behavioral effects. In addition, no changes in pain threshold were noted with alphaxalone (8 mg/kg) in the tail-flick analgesia test. These results suggest that the pharmacologic substrates for the anxiolytic actions of alphaxalone may be independent of either the benzodiazepine or picrotoxinin binding sites of the gamma-aminobutyric acid/benzodiazepine receptor complex. JF - The Journal of pharmacology and experimental therapeutics AU - Britton, K T AU - Page, M AU - Baldwin, H AU - Koob, G F AD - Department of Psychiatry, San Diego Veterans' Administration Medical Center, California. Y1 - 1991/07/01/ PY - 1991 DA - 1991 Jul 01 SP - 124 EP - 129 VL - 258 IS - 1 SN - 0022-3565, 0022-3565 KW - Anesthetics KW - 0 KW - Anti-Anxiety Agents KW - Pregnanediones KW - alphaxalone KW - BD07M97B2A KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Injections, Intraperitoneal KW - Bicuculline -- pharmacology KW - Animals KW - Drug Interactions KW - Male KW - Conditioning, Operant -- drug effects KW - Behavior, Animal -- drug effects KW - Anti-Anxiety Agents -- pharmacology KW - Anesthetics -- pharmacology KW - Pregnanediones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80683109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Anxiolytic+activity+of+steroid+anesthetic+alphaxalone.&rft.au=Britton%2C+K+T%3BPage%2C+M%3BBaldwin%2C+H%3BKoob%2C+G+F&rft.aulast=Britton&rft.aufirst=K&rft.date=1991-07-01&rft.volume=258&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-20 N1 - Date created - 1991-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cerebellar GABAB receptors modulate function of GABAA receptors. AN - 80666207; 1648524 AB - Interactions between GABAA and GABAB receptors were studied using muscimol-stimulated uptake of 36Cl- by membrane vesicles from mouse cerebellum. Baclofen inhibited muscimol-stimulated 36Cl- uptake and this action was more pronounced with longer flux times (30 vs. 3 s) and after predesensitization of GABAA receptors. Baclofen also inhibited 36Cl- flux by cortical membranes but was more effective with cerebellar preparations. The action of baclofen was stereoselective, calcium-dependent, and blocked by the GABAB receptor antagonist 2-OH-saclofen. It was mimicked by GTP-gamma-S but not by GDP-beta-S, which suggests that baclofen may be acting via a G protein. The action of baclofen was inhibited by U73122, an inhibitor of phospholipase C. However, the potassium channel blockers tetraethylammonium or Ba2+ did not affect the action of baclofen. The results show that activation of GABAB receptors can inhibit the function of GABAA receptors and suggest that this action involves either a nondesensitizing subtype of GABAA receptor or the rate or recycling of desensitized to nondesensitized receptors. We speculate that this action of baclofen results from activation of phospholipase C and phosphorylation of a subtype of GABAA receptor by protein kinase C. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Hahner, L AU - McQuilkin, S AU - Harris, R A AD - Veterans Administration Medical Center, Denver, Colorado. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 2466 EP - 2472 VL - 5 IS - 10 SN - 0892-6638, 0892-6638 KW - Estrenes KW - 0 KW - Pyrrolidinones KW - Receptors, GABA-A KW - Tetraethylammonium Compounds KW - guanosine 5'-O-(1-thiotriphosphate) KW - 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione KW - 112648-68-7 KW - 2-hydroxysaclofen KW - 117354-64-0 KW - Barium KW - 24GP945V5T KW - Muscimol KW - 2763-96-4 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Chlorine KW - 4R7X1O2820 KW - Tetraethylammonium KW - 66-40-0 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Baclofen KW - H789N3FKE8 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Type C Phospholipases -- antagonists & inhibitors KW - Cerebral Cortex -- metabolism KW - Dose-Response Relationship, Drug KW - Tetraethylammonium Compounds -- pharmacology KW - Baclofen -- analogs & derivatives KW - Mice KW - Guanosine 5'-O-(3-Thiotriphosphate) -- analogs & derivatives KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Calcium -- metabolism KW - Cells, Cultured KW - In Vitro Techniques KW - Estrenes -- pharmacology KW - Time Factors KW - Pyrrolidinones -- pharmacology KW - Muscimol -- pharmacology KW - Chlorine -- pharmacokinetics KW - Baclofen -- pharmacology KW - Barium -- pharmacology KW - Receptors, GABA-A -- physiology KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80666207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Cerebellar+GABAB+receptors+modulate+function+of+GABAA+receptors.&rft.au=Hahner%2C+L%3BMcQuilkin%2C+S%3BHarris%2C+R+A&rft.aulast=Hahner&rft.aufirst=L&rft.date=1991-07-01&rft.volume=5&rft.issue=10&rft.spage=2466&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ammonia-induced astrocyte swelling in primary culture. AN - 72463749; 1944774 AB - The effect of ammonia on water space of astrocytes in culture was determined as a means of studying the neurotoxicity of ammonia in fulminant hepatic failure (FHF). Treatment of primary astrocyte cultures obtained from neonatal rat cortices with 10 mM NH4Cl for 4 days resulted in a 29% increase in astrocytic water space, as measured by an isotopic method utilizing 3-O-methyl-[3H]-glucose. This effect was time- and dose-dependent. The ammonia-induced swelling was reversible as the water space in cultures treated with 10 mH NH4Cl for 3 days, and then returned to normal culture media for 1 day, was similar to control cultures. These findings suggest that elevated levels of ammonia lead to astrocyte swelling and may contribute to the brain edema in FHF. JF - Neurochemical research AU - Norenberg, M D AU - Baker, L AU - Norenberg, L O AU - Blicharska, J AU - Bruce-Gregorios, J H AU - Neary, J T AD - Laboratory of Neuropathology, Veterans Administration Medical center, Miami, FL. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 833 EP - 836 VL - 16 IS - 7 SN - 0364-3190, 0364-3190 KW - Methylglucosides KW - 0 KW - Ammonium Chloride KW - 01Q9PC255D KW - Tritium KW - 10028-17-8 KW - 3-O-Methylglucose KW - 146-72-5 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Inbred F344 KW - Methylglucosides -- metabolism KW - Cells, Cultured KW - Kinetics KW - Intracellular Fluid -- physiology KW - Intracellular Fluid -- drug effects KW - Cerebral Cortex -- physiology KW - Astrocytes -- cytology KW - Astrocytes -- drug effects KW - Astrocytes -- physiology KW - Ammonium Chloride -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72463749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Ammonia-induced+astrocyte+swelling+in+primary+culture.&rft.au=Norenberg%2C+M+D%3BBaker%2C+L%3BNorenberg%2C+L+O%3BBlicharska%2C+J%3BBruce-Gregorios%2C+J+H%3BNeary%2C+J+T&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1991-07-01&rft.volume=16&rft.issue=7&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-17 N1 - Date created - 1991-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - When they drink too much. Nursing interventions for patients with disordered water balance. AN - 72049241; 1875307 AB - Disordered water balance affects as many as 60% of severely psychiatrically disabled persons. Most patients do not progress to the point of a medical emergency, but are in a state of mild chronic intoxication, making them unavailable for treatment and requiring nursing care to treat the effects of the chronic intoxicated state. Interventions depend on the severity of the disordered water balance and vary from teaching fluid intake control to controlling all patient access to fluids. Nursing management of water intoxication is a trial and error approach. Through a thorough assessment and close observation of the patient, the nurse can determine which interventions would be most appropriate for the patient. JF - Journal of psychosocial nursing and mental health services AU - Snider, K AU - Boyd, M A AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 10 EP - 16 VL - 29 IS - 7 SN - 0279-3695, 0279-3695 KW - Index Medicus KW - Nursing KW - Nursing Diagnosis KW - Nursing Assessment KW - Humans KW - Water Intoxication -- nursing KW - Psychiatric Nursing -- methods KW - Patient Care Planning KW - Water Intoxication -- physiopathology KW - Water Intoxication -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72049241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=When+they+drink+too+much.+Nursing+interventions+for+patients+with+disordered+water+balance.&rft.au=Snider%2C+K%3BBoyd%2C+M+A&rft.aulast=Snider&rft.aufirst=K&rft.date=1991-07-01&rft.volume=29&rft.issue=7&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-24 N1 - Date created - 1991-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months. AN - 72047486; 1908248 AB - Studies on fatty acid oxidation were made in rats fed for 6 months on a liquid diet containing 15% total calories as ethanol. After 6 months, a marked diminution was observed in the in vivo production of 14CO2 from labeled palmitate and octanoate in the ethanol-fed animals compared to their pair-fed isocaloric controls not receiving alcohol. Similar results were obtained in 14CO2 formation from 14C-fatty acids using liver mitochondria from these ethanol-fed rats after 6 months. The effect on octanoate beta-oxidation was larger than that for palmitate. Addition of purified acyl CoA dehydrogenase complexes and additional electron transfer flavoprotein complex to the mitochondria suggested that the ethanol-fed animals could have been deficient in the medium-chain acyl CoA-dehydrogenase complex. JF - Alcohol (Fayetteville, N.Y.) AU - Rabinowitz, J L AU - Staeffen, J AU - Hall, C L AU - Brand, J G AD - Veterans Administration Medical Center, Philadelphia, PA 19104. PY - 1991 SP - 241 EP - 246 VL - 8 IS - 4 SN - 0741-8329, 0741-8329 KW - Carbon Dioxide KW - 142M471B3J KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Mitochondria, Liver -- metabolism KW - Mitochondria, Liver -- drug effects KW - Carbon Dioxide -- metabolism KW - Male KW - Alcoholism -- metabolism KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72047486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=A+probable+defect+in+the+beta-oxidation+of+lipids+in+rats+fed+alcohol+for+6+months.&rft.au=Rabinowitz%2C+J+L%3BStaeffen%2C+J%3BHall%2C+C+L%3BBrand%2C+J+G&rft.aulast=Rabinowitz&rft.aufirst=J&rft.date=1991-07-01&rft.volume=8&rft.issue=4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The antisocial personality disorder diagnosis in substance abusers: problems and issues. AN - 72033017; 1869868 AB - This paper examines the question of whether antisocial personality disorder (APD) can be considered a viable substance abuse typology. The data for APD substance abusers are first reviewed with respect to six properties that apply to establishing the validity of a clinical typology. This is followed by a brief description of the historical context and development of current conceptualizations of antisocial personality. Some possible sources of diagnostic unreliability and instability that could serve to limit the validity of the APD diagnosis are then discussed. Finally, evidence indicating considerable psychiatric heterogeneity within APD substance abusers is described. The findings indicate that although APD substance abusers satisfy many of the criteria for a clinical subtype, the fit is sufficiently imprecise to suggest the need for further refinement. We attempt to point out some of the critical questions, issues, and lines of research that could help to guide future efforts to clarify, refine, and revise the APD formulation, particularly as it applies to substance abusers. JF - The Journal of nervous and mental disease AU - Alterman, A I AU - Cacciola, J S AD - Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 401 EP - 409 VL - 179 IS - 7 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Reproducibility of Results KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- classification KW - Prognosis KW - Terminology as Topic KW - Personality Assessment KW - Alcoholism -- psychology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- classification KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- classification KW - Antisocial Personality Disorder -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72033017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=The+antisocial+personality+disorder+diagnosis+in+substance+abusers%3A+problems+and+issues.&rft.au=Alterman%2C+A+I%3BCacciola%2C+J+S&rft.aulast=Alterman&rft.aufirst=A&rft.date=1991-07-01&rft.volume=179&rft.issue=7&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-18 N1 - Date created - 1991-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of a maxillary speech-aid prosthesis for the combined tongue and mandibular resection patient. AN - 85263347; pmid-2072328 AB - The purpose of this investigation was to develop a protocol for the fabrication of a prosthesis that would improve speech in individuals who have undergone complete removal of the tongue and mandible. A 60-year-old man was suffering from severe xerostomia and was unable to produce intelligible speech. Speech analysis without the prosthesis revealed a profound articulatory disorder. With the prosthesis, xerostomia was eliminated and the subject had fewer articulatory errors of severity. Improvement in speech intelligibility was significant at p less than 0.001. JF - The Journal of Prosthetic Dentistry AU - Arcuri, M R AU - Perlman, A L AU - Philippbar, S A AU - Barkmeier, J M AD - Veterans Administration Medical Center, Iowa City, Iowa. PY - 1991 SP - 816 EP - 822 VL - 65 IS - 6 SN - 0022-3913, 0022-3913 KW - Tongue Neoplasms KW - Human KW - Phonetics KW - Speech Intelligibility KW - Speech Therapy KW - Sound Spectrography KW - Surgical Flaps KW - Xerostomia KW - Mandible KW - Articulation Disorders KW - Middle Age KW - Prosthesis Design KW - Case Report KW - Tongue KW - Carcinoma, Squamous Cell KW - Male KW - Maxillofacial Prosthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85263347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Prosthetic+Dentistry&rft.atitle=The+effects+of+a+maxillary+speech-aid+prosthesis+for+the+combined+tongue+and+mandibular+resection+patient.&rft.au=Arcuri%2C+M+R%3BPerlman%2C+A+L%3BPhilippbar%2C+S+A%3BBarkmeier%2C+J+M&rft.aulast=Arcuri&rft.aufirst=M&rft.date=1991-06-01&rft.volume=65&rft.issue=6&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Prosthetic+Dentistry&rft.issn=00223913&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Interleukin-2, cisplatin, and 5-fluorouracil for patients with non-small cell lung and head/neck carcinomas. AN - 80730465; 1651106 AB - The feasibility and efficacy of treating patients with locally recurrent or metastatic non-small cell lung cancer (NSCLC) or head/neck cancer with interleukin-2 (IL-2), cisplatin, and 5-fluorouracil (5-FU) was tested. Treatment was given every 28 days and consisted of cisplatin, 100 mg/m2 on days 1 and 8; 5-FU, 1,000 mg/m2 by continuous infusion on days 1-3; and IL-2, 12 million units/m2 by i.v. bolus on days 15-19. Thirty-four patients (22 NSCLC, 12 head/neck cancer) were registered in the study. The median age was 58 years; 59% had Karnofsky performance status of 70-80% and over one-half received prior therapy. All patients were evaluable for toxicity and 29 (18 NSCLC, 11 head/neck cancer) were evaluable for response. Twenty-five patients experienced at least one grade 3 or 4 toxicity, but these toxicities were transient and, in general, well tolerated. The response rate was 37% for NSCLC (0 complete response, 7 partial response) and 55% for head/neck cancer (2 complete response, 4 partial response). Two patients with head/neck cancer responded to treatment after failing prior therapy with cisplatin/5-FU alone. The combination of IL-2, cisplatin, and 5-FU is tolerable and active for treatment of NSCLC and head/neck carcinoma; the combination may not be cross-resistant with other chemotherapy combinations. Further studies of IL-2 combined with cisplatin/5-FU are warranted to determine the most effective dose and schedule. JF - Journal of immunotherapy : official journal of the Society for Biological Therapy AU - Valone, F H AU - Gandara, D R AU - Deisseroth, A B AU - Perez, E A AU - Rayner, A AU - Aronson, F R AU - Luce, J AU - Paradise, C AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94941. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 207 EP - 213 VL - 10 IS - 3 SN - 1053-8550, 1053-8550 KW - Interleukin-2 KW - 0 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Drug Evaluation KW - Interleukin-2 -- administration & dosage KW - Drug Administration Schedule KW - Survival Rate KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Cisplatin -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- drug therapy KW - Head and Neck Neoplasms -- mortality KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80730465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.atitle=Interleukin-2%2C+cisplatin%2C+and+5-fluorouracil+for+patients+with+non-small+cell+lung+and+head%2Fneck+carcinomas.&rft.au=Valone%2C+F+H%3BGandara%2C+D+R%3BDeisseroth%2C+A+B%3BPerez%2C+E+A%3BRayner%2C+A%3BAronson%2C+F+R%3BLuce%2C+J%3BParadise%2C+C&rft.aulast=Valone&rft.aufirst=F&rft.date=1991-06-01&rft.volume=10&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%3A+official+journal+of+the+Society+for+Biological+Therapy&rft.issn=10538550&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-17 N1 - Date created - 1991-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validity of the MCMI Drug Abuse Scale varies as a function of drug choice, race, and axis II subtypes. AN - 80716644; 1862789 AB - The validity of the Drug Abuse Scale (T) from the Million Clinical Multiaxial Inventory (MCMI) was studied by administering the MCMI to 110 male veterans seeking treatment for opioid or cocaine dependence. Only 26 and 23% of the sample obtained base rate (BR) scores above the clinical relevant cutoffs of 84 and 74, respectively. Covariables associated with elevated scores on the T Scale were Black race, presence of narcissistic/antisocial personality features, and more severe psychopathology in general. The authors urge caution in using the Drug Abuse Scale for the purpose of identifying drug abusers. JF - The American journal of drug and alcohol abuse AU - Calsyn, D A AU - Saxon, A J AU - Daisy, F AD - Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 153 EP - 159 VL - 17 IS - 2 SN - 0095-2990, 0095-2990 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Prognosis KW - Psychometrics KW - Male KW - Opioid-Related Disorders -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Personality Disorders -- diagnosis KW - Opioid-Related Disorders -- psychology KW - Personality Inventory -- statistics & numerical data KW - African Americans -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Personality Disorders -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Personality Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80716644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Validity+of+the+MCMI+Drug+Abuse+Scale+varies+as+a+function+of+drug+choice%2C+race%2C+and+axis+II+subtypes.&rft.au=Calsyn%2C+D+A%3BSaxon%2C+A+J%3BDaisy%2C+F&rft.aulast=Calsyn&rft.aufirst=D&rft.date=1991-06-01&rft.volume=17&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isobolographic analysis of analgesic interactions between intrathecally and intracerebroventricularly administered fentanyl, morphine and D-Ala2-D-Leu5-enkephalin in morphine-tolerant and nontolerant mice. AN - 80603181; 1646321 AB - Concurrent administration of morphine sulfate i.c.v. and i.t. produces a multiplicative interaction for analgesia in the tail flick response in mice. This interaction decreases to an additive interaction in mice which are tolerant to s.c. morphine. To test the responses of opioids selective for mu or delta receptors, the present study examined the interactions between fentanyl citrate (mu agonist) and D-Ala2-D-Leu5 enkephalin (DADLE, a relatively selective delta agonist) administered i.c.v. and i.t. using the tail flick test in control and morphine pellet-implanted mice. A method was developed for assigning statistical significance to the resulting ED50 values when analyzed isobolographically. When fentanyl or DADLE was administered i.c.v. plus i.t., an additive interaction between sites occurred in control animals, which changed to an antagonistic interaction for fentanyl and a multiplicative interaction for DADLE after morphine pellet treatment. When morphine was given i.c.v. along with i.t. fentanyl or DADLE in control animals, multiplicative interactions occurred when equipotent doses were given. Thus, opioids which were more receptor-selective than morphine did not produce multiplicative interactions, but were multiplicative when given with morphine. These results suggest that activation of combinations of receptors (by morphine) was required for the multiplicative interaction. The supraspinal site involved mu receptors (which are not self-sufficient and require an additional component) and the spinal site involved mu or delta receptors. The use of isobolographic analysis required that the drugs, when administered concurrently at two sites, be given in a constant dose ratio. JF - The Journal of pharmacology and experimental therapeutics AU - Roerig, S C AU - Hoffman, R G AU - Takemori, A E AU - Wilcox, G L AU - Fujimoto, J M AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 1091 EP - 1099 VL - 257 IS - 3 SN - 0022-3565, 0022-3565 KW - Receptors, Opioid KW - 0 KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - Enkephalin, Leucine-2-Alanine KW - 63631-40-3 KW - Morphine KW - 76I7G6D29C KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Drug Tolerance KW - Animals KW - Drug Interactions KW - Injections, Spinal KW - Mice KW - Male KW - Receptors, Opioid -- physiology KW - Mathematics KW - Injections, Intraventricular KW - Fentanyl -- pharmacology KW - Enkephalin, Leucine-2-Alanine -- pharmacology KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80603181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Isobolographic+analysis+of+analgesic+interactions+between+intrathecally+and+intracerebroventricularly+administered+fentanyl%2C+morphine+and+D-Ala2-D-Leu5-enkephalin+in+morphine-tolerant+and+nontolerant+mice.&rft.au=Roerig%2C+S+C%3BHoffman%2C+R+G%3BTakemori%2C+A+E%3BWilcox%2C+G+L%3BFujimoto%2C+J+M&rft.aulast=Roerig&rft.aufirst=S&rft.date=1991-06-01&rft.volume=257&rft.issue=3&rft.spage=1091&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-12 N1 - Date created - 1991-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium citrate markedly enhances aluminum absorption from aluminum hydroxide. AN - 80596840; 2042654 AB - The effect of calcium citrate on intestinal aluminum absorption, assessed by the increment in urinary aluminum excretion, was evaluated in eight normal men. Baseline urinary aluminum excretion was determined for 2 days; thereafter, subjects ingested aluminum hydroxide for 3 days. In a cross-over study, subjects were given either calcium citrate, 950 mg four times a day, or placebo during the 3 days of aluminum hydroxide ingestion (2.4 g/d). Plasma aluminum levels were measured on the second control day and the third day of aluminum hydroxide ingestion. Baseline urinary aluminum excretion was 0.02 +/- 0.004 (6.5 +/- 1.1 micrograms/g creatinine) and 0.03 +/- 0.005 mumol/mmol creatinine (7.4 +/- 1.3 micrograms/g creatinine). These values increased during aluminum hydroxide therapy, but values were much greater when calcium citrate was ingested with aluminum hydroxide. On 3 consecutive days, urinary aluminum excretion levels were 11.1 +/- 3.23, 8.8 +/- 2.9, and 5.3 +/- 0.7 times greater during the administration of calcium citrate with aluminum hydroxide than with aluminum hydroxide alone. Plasma aluminum levels did not differ in the two treatment groups. Thus, calcium citrate markedly enhances the absorption of aluminum from aluminum hydroxide and the two must not be prescribed together in patients with renal failure. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Coburn, J W AU - Mischel, M G AU - Goodman, W G AU - Salusky, I B AD - Medical Service, West Los Angeles Veterans Administration Center (Wadsworth Division), CA 90073. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 708 EP - 711 VL - 17 IS - 6 SN - 0272-6386, 0272-6386 KW - Antacids KW - 0 KW - Citrates KW - Citric Acid KW - 2968PHW8QP KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Reference Values KW - Humans KW - Adult KW - Middle Aged KW - Intestinal Absorption -- drug effects KW - Drug Synergism KW - Time Factors KW - Male KW - Aluminum -- urine KW - Antacids -- contraindications KW - Aluminum -- blood KW - Citrates -- contraindications KW - Antacids -- pharmacokinetics KW - Aluminum Hydroxide -- contraindications KW - Aluminum -- pharmacokinetics KW - Citrates -- pharmacokinetics KW - Aluminum Hydroxide -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80596840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Calcium+citrate+markedly+enhances+aluminum+absorption+from+aluminum+hydroxide.&rft.au=Coburn%2C+J+W%3BMischel%2C+M+G%3BGoodman%2C+W+G%3BSalusky%2C+I+B&rft.aulast=Coburn&rft.aufirst=J&rft.date=1991-06-01&rft.volume=17&rft.issue=6&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-10 N1 - Date created - 1991-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mucosal vascular stasis precedes loss of viability of endothelial cells in rat acetic acid colitis. AN - 80563138; 2032512 AB - The hypothesis that a significant reduction in colonic mucosal perfusion, and hence ischemic injury, precedes the development of mucosal ulceration and inflammation is tested in this report. The microcirculatory changes in the rat colonic mucosa within 1 hr of topical exposure to 10% acetic acid were assessed. Colonic mucosal blood flow signals measured by laser Doppler flowmetry were significantly reduced to 61 +/- 8, 52 +/- 10, and 37 +/- 13% (mean +/- SEM) of baseline values at 1 min, 4 min, and 10 min after the colonic mucosa was exposed to 10% acetic acid, respectively, but not in controls exposed to saline. After the start of application of 10% acetic acid (for 4 min), in vivo microscopy studies demonstrated that colonic mucosal ischemia (stasis of the red blood cells in the mucosal capillaries) occurred at 9 +/- 5 min (mean +/- SEM). Evidence of endothelial cell death (failure to exclude a fluorescent dye, propidium iodide, by endothelial cells) developed at 25 +/- 10 min (mean +/- SEM). These findings indicate that within minutes after contact of the colonic mucosa with 10% acetic acid, colonic mucosal ischemia develops, followed shortly by death of endothelial cells. The data do not establish a cause-and-effect relationship between the reductions in mucosal blood flow and loss of endothelial cell viability in response to acetic acid. Nevertheless, because these events occur at such an early time point, they may play a pathogenetic role in the development of the subsequent inflammatory and ulcerative changes in this animal model of colitis. Further studies to define the potential causal relationships between these parameters are warranted. JF - Digestive diseases and sciences AU - Leung, F W AU - Koo, A AD - Research Service, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 727 EP - 732 VL - 36 IS - 6 SN - 0163-2116, 0163-2116 KW - Acetates KW - 0 KW - Acetic Acid KW - Q40Q9N063P KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Microcirculation -- drug effects KW - Regional Blood Flow -- drug effects KW - Time Factors KW - Endothelium, Vascular -- pathology KW - Colitis -- pathology KW - Colitis -- chemically induced KW - Ischemia -- chemically induced KW - Intestinal Mucosa -- blood supply KW - Colon -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80563138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Mucosal+vascular+stasis+precedes+loss+of+viability+of+endothelial+cells+in+rat+acetic+acid+colitis.&rft.au=Leung%2C+F+W%3BKoo%2C+A&rft.aulast=Leung&rft.aufirst=F&rft.date=1991-06-01&rft.volume=36&rft.issue=6&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. AN - 80562415; 2033247 AB - Ligand-induced activation of T cells results in stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC). A structurally diverse family of PI-PLC isoforms has recently been defined, and more than one isoform is frequently coexpressed in a single cell or tissue, suggesting that different forms may play distinct roles in cellular activation, proliferation, or differentiation. We show here that both PLC-alpha and PLC-gamma are expressed in rat splenic T cells and in Jurkat cells (a human T cell line). Activation of Jurkat cells with the combination of PMA and PHA leads to increased expression of PLC-alpha message and decreased expression of PLC-gamma message after 4 h of stimulation. The increase in PLC-alpha transcripts was detectable at 4 h, maximal at 6 h, and remained elevated for at least 24 h. The decrease in PLC-gamma message was transient, with a maximal effect at 4 h, and a return to basal levels by 6 h. Changes in PI-PLC transcripts were also induced by the combination of PMA and the calcium ionophore, ionomycin. These data demonstrate that the expression of transcripts for PLC-alpha and PLC-gamma can be differentially regulated during a cellular response, and raise the possibility that these two isoforms of PI-PLC subserve distinct functions in T cell activation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Goldfien, R D AU - Seaman, W E AU - Hempel, W M AU - Imboden, J B AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/06/01/ PY - 1991 DA - 1991 Jun 01 SP - 3703 EP - 3708 VL - 146 IS - 11 SN - 0022-1767, 0022-1767 KW - Isoenzymes KW - 0 KW - Phytohemagglutinins KW - Type C Phospholipases KW - EC 3.1.4.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Phytohemagglutinins -- pharmacology KW - Cell Line KW - Lymphocyte Activation KW - Isoenzymes -- biosynthesis KW - Type C Phospholipases -- biosynthesis KW - Transcription, Genetic KW - Type C Phospholipases -- genetics KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80562415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Divergent+regulation+of+phospholipase+C-alpha+and+phospholipase+C-gamma+transcripts+during+activation+of+a+human+T+cell+line.&rft.au=Goldfien%2C+R+D%3BSeaman%2C+W+E%3BHempel%2C+W+M%3BImboden%2C+J+B&rft.aulast=Goldfien&rft.aufirst=R&rft.date=1991-06-01&rft.volume=146&rft.issue=11&rft.spage=3703&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-25 N1 - Date created - 1991-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Squamous cell carcinoma of the scrotum. AN - 72060144; 1879176 AB - A patient with psoriasis was found to have a large mass on his scrotum. He was at increased risk for the occurrence of skin cancer, both from the treatments he received for control of his psoriasis and from previous occupational exposure. We present his case and review the risk factors involved. JF - Cutis AU - Gross, D J AU - Schosser, R H AD - Department of Dermatology, John L. McClellan Veterans Administration Hospital, Little Rock, Arkansas. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 402 EP - 404 VL - 47 IS - 6 SN - 0011-4162, 0011-4162 KW - Polycyclic Compounds KW - 0 KW - Index Medicus KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- pathology KW - Risk Factors KW - Humans KW - Psoriasis -- drug therapy KW - Occupational Exposure -- adverse effects KW - Aged KW - Polycyclic Compounds -- adverse effects KW - Male KW - Genital Neoplasms, Male -- pathology KW - Scrotum -- pathology KW - Genital Neoplasms, Male -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72060144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Squamous+cell+carcinoma+of+the+scrotum.&rft.au=Gross%2C+D+J%3BSchosser%2C+R+H&rft.aulast=Gross&rft.aufirst=D&rft.date=1991-06-01&rft.volume=47&rft.issue=6&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-02 N1 - Date created - 1991-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes with age in the proliferative response of splenic T cells from rats exposed to ethanol in utero. AN - 72053114; 1877729 AB - The fetal alcohol syndrome is associated with altered immunity. Several laboratories have confirmed that rodents exposed to ethanol in utero demonstrate both diminished proliferative responses of T cells to mitogens and diminished proliferative responses of T-blast cells to human recombinant interleukin 2 (rIL2). We examined the developmental time course of these altered immune responses by testing the immune function of in utero ethanol-exposed rats at various ages. We found that while diminished splenic T cell proliferative responses could not be detected at 2 weeks, they were present at 6 weeks after birth and suppression was maximal at 6 weeks and 3 months. Thereafter, at 5 and 7 months, the altered immune responses gradually declined and normalized at 8 months of age. Thus, both altered T cell mitogenesis and the blunted IL2-induced proliferative response of T-blast cells could serve as biomarkers of fetal exposure to ethanol. JF - Alcoholism, clinical and experimental research AU - Norman, D C AU - Chang, M P AU - Wong, C M AU - Branch, B J AU - Castle, S AU - Taylor, A N AD - GRECC, Veterans Administration Medical Center West Lost Angeles, CA 90073. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 428 EP - 432 VL - 15 IS - 3 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Immune Tolerance -- drug effects KW - Animals KW - Age Factors KW - Spleen -- immunology KW - Immune Tolerance -- immunology KW - Spleen -- drug effects KW - Male KW - Female KW - Pregnancy KW - Lymphocyte Activation -- drug effects KW - Lymphocyte Activation -- immunology KW - Ethanol -- toxicity KW - T-Lymphocytes -- drug effects KW - Fetal Alcohol Spectrum Disorders -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72053114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Changes+with+age+in+the+proliferative+response+of+splenic+T+cells+from+rats+exposed+to+ethanol+in+utero.&rft.au=Norman%2C+D+C%3BChang%2C+M+P%3BWong%2C+C+M%3BBranch%2C+B+J%3BCastle%2C+S%3BTaylor%2C+A+N&rft.aulast=Norman&rft.aufirst=D&rft.date=1991-06-01&rft.volume=15&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin B12 and folate status in rats after chronic administration of ethanol and acute exposure to nitrous oxide. AN - 72050457; 1877742 AB - The chronic administration of ethanol or brief exposure to nitrous oxide (N2O) decreases the activity of hepatic methionine synthase and disrupts normal metabolic processes that require folate and vitamin B12. This combination of drugs has clinical relevance since alcoholic patients often require surgery and receive N2O as a component of their anesthetic. To assess this clinical problem using a rodent model, rats were given a liquid ethanol diet (35% of calories as ethanol) and control rats were pair-fed a liquid diet with carbohydrate substituting for the caloric content of ethanol. After receiving liquid diets for 6 weeks, rats were exposed to 60% N2O/40% O2 for 6 hr. Urinary excretions of formic acid and formiminoglutamic acid (FIGLU) were used as indirect markers of folate status. In both the ethanol-fed and control groups, excretion of formic acid and FIGLU markedly increased the first day after N2O and returned towards background values by the second day after N2O exposure. Ethanol treatment alone decreased methionine synthase activities in liver, but not kidney or brain. Exposure to N2O further decreased methionine synthase activities, and recovery of methionine synthase activity after N2O occurred over a period of 4 days at the same rate in both the ethanol-fed and control groups. Ethanol treatment for 6 weeks combined with acute exposure to N2O did not deplete the rats of vitamin B12 in blood, liver, kidney, or brain. We conclude that in this animal model, chronic treatment with ethanol does not markedly exacerbate the disturbances in folate/vitamin B12 metabolism caused by brief exposure to N2O. JF - Alcoholism, clinical and experimental research AU - Koblin, D D AU - Everman, B W AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 543 EP - 548 VL - 15 IS - 3 SN - 0145-6008, 0145-6008 KW - Formates KW - 0 KW - formic acid KW - 0YIW783RG1 KW - Formiminoglutamic Acid KW - 816-90-0 KW - Folic Acid KW - 935E97BOY8 KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase KW - EC 2.1.1.13 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Liver -- enzymology KW - Liver -- drug effects KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- blood KW - Formiminoglutamic Acid -- urine KW - Formates -- urine KW - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase -- antagonists & inhibitors KW - Male KW - Alcoholism -- enzymology KW - Nitrous Oxide -- toxicity KW - Folic Acid -- blood KW - Vitamin B 12 -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72050457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Vitamin+B12+and+folate+status+in+rats+after+chronic+administration+of+ethanol+and+acute+exposure+to+nitrous+oxide.&rft.au=Koblin%2C+D+D%3BEverman%2C+B+W&rft.aulast=Koblin&rft.aufirst=D&rft.date=1991-06-01&rft.volume=15&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beneficial effects of nicotine. AN - 80711114; 1859921 AB - Nicotine in tobacco brings illness and death to millions of people. Yet nicotine in its pure form has the potential to be a valuable pharmaceutical agent. Nicotine fairly specifically binds to the cholinergic nicotinic gating site on cationic ion channels in receptors throughout the body. This action stimulates the release of a variety of neurotransmitters including especially catecholamines and serotonin. When chronically taken, nicotine may result in: (1) positive reinforcement, (2) negative reinforcement, (3) reduction of body weight, (4) enhancement of performance, and protection against; (5) Parkinson's disease (6) Tourette's disease (7) Alzheimers disease, (8) ulcerative colitis and (9) sleep apnea. The reliability of these effects varies greatly but justifies the search for more therapeutic applications for this interesting compound. JF - British journal of addiction AU - Jarvik, M E AD - Veterans Administration Medical Center, Brentwood Division, Los Angeles. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 571 EP - 575 VL - 86 IS - 5 SN - 0952-0481, 0952-0481 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Animals KW - Affect -- drug effects KW - Arousal -- drug effects KW - Neurocognitive Disorders -- psychology KW - Humans KW - Substance Withdrawal Syndrome -- psychology KW - Smoking -- psychology KW - Attention -- drug effects KW - Mental Recall -- drug effects KW - Nicotine -- therapeutic use KW - Nicotine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80711114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+addiction&rft.atitle=Beneficial+effects+of+nicotine.&rft.au=Jarvik%2C+M+E&rft.aulast=Jarvik&rft.aufirst=M&rft.date=1991-05-01&rft.volume=86&rft.issue=5&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=British+journal+of+addiction&rft.issn=09520481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The measurement of denial and rationalization in male alcoholics. AN - 80663940; 2066419 AB - Two hundred male alcoholics were given 94 true-false items constructed to characterize alcoholic defensiveness, and a factor analysis revealed two strong factors. The first factor (Denial) was correlated with items that asserted an ability to control one's drinking, denied being an alcoholic or needing treatment, or minimized the consequences of alcohol abuse. Items that loaded the other factor (Rationalization) gave reasons, justifications, and excuses for drinking. Two derived scales were examined in a replication sample of 66 male alcoholics, and alpha coefficients (.84 and .85) from the first sample did not show undue shrinkage in the second (.86 and .77). JF - Journal of clinical psychology AU - Ward, L C AU - Rothaus, P AD - Veterans Administration Medical Center Tuscaloosa, Alabama. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 465 EP - 468 VL - 47 IS - 3 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Verbal Behavior KW - Humans KW - Adult KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Defense Mechanisms KW - Alcoholism -- rehabilitation KW - Denial (Psychology) KW - Rationalization KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80663940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=The+measurement+of+denial+and+rationalization+in+male+alcoholics.&rft.au=Ward%2C+L+C%3BRothaus%2C+P&rft.aulast=Ward&rft.aufirst=L&rft.date=1991-05-01&rft.volume=47&rft.issue=3&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-14 N1 - Date created - 1991-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. AN - 80555130; 2029994 AB - To assess the effectiveness of propranolol in the prevention of initial variceal hemorrhage, a double-blind, randomized trial was carried out in three centers. Patients with cirrhosis (78% alcoholic), hepatic venous pressure gradients greater than 12 mm Hg and endoscopically proven esophageal varices were randomly assigned to propranolol (51 patients) or placebo (51 patients). Of the 102 patients, 58% were Child's class A, 34% were Child's class B and 8% were Child's class C. Daily dosage was determined by the administration of progressively increasing doses of propranolol with the hepatic vein catheter in place to achieve a 25% decrease in hepatic venous pressure gradient, a decrease in hepatic venous pressure gradient to less than 12 mm Hg or a decrease in resting heart rate to less than 55 beats/min. During a mean follow-up period of 16.3 mo, 11 patients in the placebo group (22%) bled from esophageal varices compared with 2 in the propranolol group (4%) during a mean period of 17.1 mo (p less than 0.01). Three additional patients (6%) in the placebo group bled from portal hypertensive gastropathy compared with none in the propranolol group. Propranolol appeared effective in preventing bleeding from large varices. Eleven deaths (22%) occurred in the placebo group compared with eight deaths (16%) in the propranolol group (NS). The mean dose of propranolol was 132 mg/day, and the median dose was 80 mg/day. Using a compliance index (pill count, clinic attendance, alcohol and propranolol levels and alcohol history), 81% of the propranolol patients and 77% of the placebo patients were considered compliant. Complications severe enough to require cessation of therapy occurred in eight patients (16%) in the propranolol group and four in the placebo group (8%) (NS). We conclude that propranolol effectively prevents the first variceal hemorrhage in patients with alcoholic cirrhosis and large esophageal varices but does not improve survival. JF - Hepatology (Baltimore, Md.) AU - Conn, H O AU - Grace, N D AU - Bosch, J AU - Groszmann, R J AU - Rodés, J AU - Wright, S C AU - Matloff, D S AU - Garcia-Tsao, G AU - Fisher, R L AU - Navasa, M AD - Medical Service, West Haven Veterans Administration Medical Center, Yale University School of Medicine, Connecticut 06516. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 902 EP - 912 VL - 13 IS - 5 SN - 0270-9139, 0270-9139 KW - Propranolol KW - 9Y8NXQ24VQ KW - Index Medicus KW - Liver Cirrhosis, Alcoholic -- complications KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Patient Compliance KW - Humans KW - Middle Aged KW - Hypertension, Portal -- complications KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Propranolol -- therapeutic use KW - Gastrointestinal Hemorrhage -- prevention & control KW - Esophageal and Gastric Varices -- complications KW - Propranolol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80555130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Propranolol+in+the+prevention+of+the+first+hemorrhage+from+esophagogastric+varices%3A+A+multicenter%2C+randomized+clinical+trial.+The+Boston-New+Haven-Barcelona+Portal+Hypertension+Study+Group.&rft.au=Conn%2C+H+O%3BGrace%2C+N+D%3BBosch%2C+J%3BGroszmann%2C+R+J%3BRod%C3%A9s%2C+J%3BWright%2C+S+C%3BMatloff%2C+D+S%3BGarcia-Tsao%2C+G%3BFisher%2C+R+L%3BNavasa%2C+M&rft.aulast=Conn&rft.aufirst=H&rft.date=1991-05-01&rft.volume=13&rft.issue=5&rft.spage=902&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-17 N1 - Date created - 1991-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. AN - 80531089; 2021479 AB - Exposure to oxidants permeabilizes cell membranes and liberates unesterified fatty acids (UFA) in a variety of cell types, including endothelial cells. Products of phospholipase activity, particularly UFA and lysophosphatides, possess potent detergent-like properties, and we postulated that oxidant injury might be mediated by the accumulation of these toxic phospholipase products. Several radiolabels were incorporated into defined positions in the phospholipids of cultured, confluent bovine pulmonary endothelial cells (BPAEC). The release of radiolabeled fatty acids and the accumulation of cell-associated phospholipase products were measured and compared to a standard cytotoxicity assay (51Cr release) in response to an oxidant stress, in this case 0.1 to 10 mM hydrogen peroxide (H2O2). H2O2 caused time- and dose-dependent 51Cr release as well as liberation of saturated ([14C]stearic acid) and unsaturated ([3H]arachidonic acid) fatty acids and the accumulation of phospholipase A2 and C products. The ability of BPAEC to incorporate UFA into complex phospholipids was shown to be severely impaired in the presence of H2O2. Further studies showed that H2O2 caused depletion of BPAEC adenosine triphosphate (ATP) content to undetectable levels, and that the depletion of cellular ATP by iodoacetic acid induced substantial release of [3H]arachidonic acid but not [14C]stearic acid from BPAEC. This finding suggests that release of UFA in response to an oxidant stress may be due in part to a defect in ATP-dependent reacylation pathways and need not reflect any increase in phospholipase activities. Also unsaturated fatty acids were found to be toxic to BPAEC upon adding them to supernatants of cultured monolayers. JF - American journal of respiratory cell and molecular biology AU - Duane, P G AU - Rice, K L AU - Charboneau, D E AU - King, M B AU - Gilboe, D P AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 408 EP - 416 VL - 4 IS - 5 SN - 1044-1549, 1044-1549 KW - Arachidonic Acids KW - 0 KW - Chromium Radioisotopes KW - Phospholipids KW - Stearic Acids KW - stearic acid KW - 4ELV7Z65AP KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Phospholipases KW - EC 3.1.- KW - Index Medicus KW - Animals KW - Cattle KW - Arachidonic Acids -- metabolism KW - Lipid Peroxidation KW - Stearic Acids -- metabolism KW - Cell Line KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Pulmonary Artery -- metabolism KW - Phospholipids -- metabolism KW - Phospholipases -- metabolism KW - Hydrogen Peroxide -- pharmacology KW - Adenosine Triphosphate -- metabolism KW - Pulmonary Artery -- enzymology KW - Pulmonary Artery -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80531089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Relationship+of+oxidant-mediated+cytotoxicity+to+phospholipid+metabolism+in+endothelial+cells.&rft.au=Duane%2C+P+G%3BRice%2C+K+L%3BCharboneau%2C+D+E%3BKing%2C+M+B%3BGilboe%2C+D+P%3BNiewoehner%2C+D+E&rft.aulast=Duane&rft.aufirst=P&rft.date=1991-05-01&rft.volume=4&rft.issue=5&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-31 N1 - Date created - 1991-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Levels of opioid physical dependence in heroin addicts. AN - 72072081; 1884668 AB - The levels of opioid physical dependence in a group of long-term heroin addicts were ascertained by measuring the severity of the opioid withdrawal syndrome before and after pharmacological challenge with either 0.4 mg naloxone or placebo. Prior to challenge, patients manifested some subjective symptoms but few objective signs of opioid withdrawal. Patients who received placebo (n = 18) showed a significant increase in the mean score on one of three rating scales used to assess opioid withdrawal. Patients who received naloxone (n = 58) showed significant increases in mean scores on all three rating scales, but this was due primarily to increases observed in a minority of patients. Sixty-one percent of patients failed to manifest clinically significant changes in subjective symptoms, and 74% of patients failed to manifest clinically significant changes in objective signs of opioid withdrawal following naloxone administration. The results suggest that a substantial subgroup of heroin addicts are able to use opioids regularly while maintaining relatively low levels of physical dependence. JF - Drug and alcohol dependence AU - Kanof, P D AU - Aronson, M J AU - Ness, R AU - Cochrane, K J AU - Horvath, T B AU - Handelsman, L AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, New York 10468. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 253 EP - 262 VL - 27 IS - 3 SN - 0376-8716, 0376-8716 KW - Naloxone KW - 36B82AMQ7N KW - Heroin KW - 70D95007SX KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Drug Tolerance KW - Methadone -- therapeutic use KW - Humans KW - Adult KW - Neurologic Examination KW - Middle Aged KW - Male KW - Heroin -- adverse effects KW - Substance Withdrawal Syndrome -- rehabilitation KW - Substance Withdrawal Syndrome -- diagnosis KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72072081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Levels+of+opioid+physical+dependence+in+heroin+addicts.&rft.au=Kanof%2C+P+D%3BAronson%2C+M+J%3BNess%2C+R%3BCochrane%2C+K+J%3BHorvath%2C+T+B%3BHandelsman%2C+L&rft.aulast=Kanof&rft.aufirst=P&rft.date=1991-05-01&rft.volume=27&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-07 N1 - Date created - 1991-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence, onset, and risk of psychiatric disorders in men with chronic low back pain: a controlled study. AN - 72053256; 1831555 AB - This study used structured diagnostic interviews and DSM-III criteria to assess lifetime prevalence and pre-morbid risk of psychiatric disorder in a sample of men with long-standing chronic back pain (CLPB) attending a primary care clinic. A control group of age and demographically matched men without history of back pain was also studied. Compared to controls, men with CLBP had significantly higher lifetime rates of major depression (32% vs. 16%), alcohol use disorder (64.9% vs. 38.8%), and a major anxiety disorder (30.9% vs. 14.3%). Almost all CLBP men ever experiencing a mood disorder reported recurrent, not single, episodes. The 6 month point prevalence of major depression, but not other disorders, was also significantly elevated for men with CLBP. In CLBP, the first episode of major depression generally (58.1%) followed pain onset. While the initial major depressive episode usually commenced within the first 2 years of established pain, late onset mood disorder was also common. By comparison in most cases (81%) onset of alcohol use disorders considerably preceded pain. When an age-matching procedure was used to gauge relative vulnerability to psychiatric illness in patients and controls, CLBP patients had significantly higher pre-pain rates of alcohol use disorder but not depression. After age of pain onset, CLBP subjects had over 9 times the risk of developing major depression, but had similar rates of developing alcoholism. We conclude that (1) alcohol use disorders rather than depression may increase risk of developing CLBP, and (2) risk of new onset and recurrent major depression remains high for men throughout their pain career. This suggests that psychological adaptation to long-standing pain may be less successful than previously thought, especially with regard to recurrent mood disorder. JF - Pain AU - Atkinson, J H AU - Slater, M A AU - Patterson, T L AU - Grant, I AU - Garfin, S R AD - Psychiatry Service, San Diego Veterans Administration Medical Center, CA 92161. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 111 EP - 121 VL - 45 IS - 2 SN - 0304-3959, 0304-3959 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Chronic Disease KW - Alcoholism -- physiopathology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Male KW - Prevalence KW - Back Pain -- psychology KW - Back Pain -- epidemiology KW - Back Pain -- physiopathology KW - Mental Disorders -- epidemiology KW - Back Pain -- complications KW - Mental Disorders -- psychology KW - Mental Disorders -- complications KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72053256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Prevalence%2C+onset%2C+and+risk+of+psychiatric+disorders+in+men+with+chronic+low+back+pain%3A+a+controlled+study.&rft.au=Atkinson%2C+J+H%3BSlater%2C+M+A%3BPatterson%2C+T+L%3BGrant%2C+I%3BGarfin%2C+S+R&rft.aulast=Atkinson&rft.aufirst=J&rft.date=1991-05-01&rft.volume=45&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=03043959&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-24 N1 - Date created - 1991-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Do-Not-Resuscitate Orders at a Chronic Care Hospital AN - 1761715243; 199200175 AB - To study the use of do-not-resuscitate (DNR) orders, their frequency, decisionmakers involved, patient characteristics, further medical interventions, & short-term outcomes, medical records of 301 patients admitted 1985/86 to a chronic care hospital in Mass were surveyed. In the first 6 weeks of hospitalization DNR orders were issued for 58 patients, requested by: their families (73%), the patients themselves (18%), & physicians (6%). Patients with DNR orders were more likely to be demented, incontinent, & unable to perform other routine functions; they continued to receive medical interventions, but were considered likely to die. 3 Tables, 20 References. M. Malas JF - Journal of the American Geriatrics Society AU - Berlowitz, Dan R AU - Wilking, Spencer V B AU - Moskowitz, Mark A AD - Medical Service Bedford Veterans Administration Hospital, 200 Springs Rd MA 01730 Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 472 EP - 476 VL - 39 IS - 5 SN - 0002-8614, 0002-8614 KW - do-not-resuscitate orders, decision-making processes, chronic care hospital patients KW - medical records KW - Massachusetts KW - Professional Ethics KW - Terminal Illness KW - Medical Technology KW - Emergencies KW - Nursing Homes KW - Treatment Methods KW - article KW - 7211: health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761715243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Do-Not-Resuscitate+Orders+at+a+Chronic+Care+Hospital&rft.au=Berlowitz%2C+Dan+R%3BWilking%2C+Spencer+V+B%3BMoskowitz%2C+Mark+A&rft.aulast=Berlowitz&rft.aufirst=Dan&rft.date=1991-05-01&rft.volume=39&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical Technology; Terminal Illness; Treatment Methods; Professional Ethics; Emergencies; Nursing Homes; Massachusetts ER - TY - JOUR T1 - Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. AN - 80523531; 1850412 AB - The signals controlling the expression of the receptor protein for 1 alpha,25-dihydroxyvitamin D3 in normal human lymphocytes and the relationship of this protein to the classical vitamin D receptor were examined. Lymphocytes activated with the OKT3 antibody to the T-cell antigen receptor expressed fewer binding sites as compared to lymphocytes that were activated by the polyclonal activator phytohemagglutinin (PHA). However, combination of OKT3 and phorbol myristate acetate produced a concentration of binding sites similar to the PHA-activated cells. The receptor from OKT3 and OKT3 + phorbol myristate acetate-activated lymphocytes exhibited decreased binding to DNA-cellulose compared to PHA-activated lymphocytes. In lymphocytes activated either by PHA or OKT3 (but not in resting cells), a 50-kDa species cross-reacting with a monoclonal antibody against the intestinal vitamin D receptor was detected. Finally, RNA from activated lymphocytes was amplified by polymerase chain reaction using oligonucleotide primers flanking the 196 base pair long region encoding the DNA-binding domain of the human intestinal receptor. The amplified product showed an identical nucleotide sequence to the DNA-binding domain of the human intestinal receptor. These findings suggest that expression of the 1,25-(OH)2D3 receptor in lymphocytes is triggered by distinct and contingent signals, and that the protein and the mRNA encoding it are identical to the classical vitamin D receptor. JF - The Journal of biological chemistry AU - Yu, X P AU - Mocharla, H AU - Hustmyer, F G AU - Manolagas, S C AD - Section of Endocrinology and Metabolism, Veterans Administration Medical Center, Indianapolis, Indiana 46202. Y1 - 1991/04/25/ PY - 1991 DA - 1991 Apr 25 SP - 7588 EP - 7595 VL - 266 IS - 12 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - Phytohemagglutinins KW - Receptors, Calcitriol KW - Receptors, Steroid KW - DNA KW - 9007-49-2 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Humans KW - Phytohemagglutinins -- pharmacology KW - Lymphocyte Activation KW - Polymerase Chain Reaction KW - Base Sequence KW - Blotting, Western KW - Chromatography, Liquid KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Flow Cytometry KW - Female KW - Male KW - DNA -- genetics KW - Receptors, Steroid -- metabolism KW - Lymphocytes -- metabolism KW - Calcitriol -- metabolism KW - Receptors, Steroid -- genetics KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80523531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Vitamin+D+receptor+expression+in+human+lymphocytes.+Signal+requirements+and+characterization+by+western+blots+and+DNA+sequencing.&rft.au=Yu%2C+X+P%3BMocharla%2C+H%3BHustmyer%2C+F+G%3BManolagas%2C+S+C&rft.aulast=Yu&rft.aufirst=X&rft.date=1991-04-25&rft.volume=266&rft.issue=12&rft.spage=7588&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-29 N1 - Date created - 1991-05-29 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M65208; GENBANK; M60204; M60203; M60205; M60206; M62780; M60256; M60257; M60258; M60259 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. AN - 80561841; 2031940 AB - Recent studies have shown that epidermal cholesterol synthesis is regulated by HMG CoA reductase activity and that this activity is modulated by changes in the cutaneous permeability barrier. Here, we quantitated HMG CoA reductase activity after acute and chronic barrier disruption in the upper and lower layers of murine epidermis. In unperturbed epidermis, 13 and 87% of enzyme activity localized to the upper and lower epidermis, respectively, with the majority of activity in the stratum basale. Acute barrier disruption with either acetone or sodium dodecylsulfate provoked an increase in HMG CoA reductase activity (54% and 30%) in the lower layers, but only a small change in the upper layers. However, the activation state of the enzyme was increased 50% in the upper epidermis. Correction of barrier function by occlusion with an impermeable Latex wrap prevented the increase both in enzyme activity and activation state. After chronic barrier disruption; i.e., essential fatty acid deficient (EFAD) diet, HMG CoA reductase activity was increased in the upper epidermis (161%); a change prevented by occlusion. These results show: (1) that HMG CoA reductase activity is present in both the upper and lower cell layers; (2) that acute insults to barrier integrity stimulate enzyme activity in both the upper and lower epidermis; and (3) that chronic insults provoke an increase in enzyme activity in the upper layers. These studies provide further insights into the linkage of the permeability barrier with epidermal cholesterol metabolism. JF - Biochimica et biophysica acta AU - Proksch, E AU - Elias, P M AU - Feingold, K R AD - Metabolism Section, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/04/24/ PY - 1991 DA - 1991 Apr 24 SP - 71 EP - 79 VL - 1083 IS - 1 SN - 0006-3002, 0006-3002 KW - Exfoliatins KW - 0 KW - Cholesterol KW - 97C5T2UQ7J KW - Hydroxymethylglutaryl CoA Reductases KW - EC 1.1.1.- KW - Index Medicus KW - Permeability KW - Animals KW - Reference Values KW - Cholesterol -- biosynthesis KW - Kinetics KW - Microsomes -- enzymology KW - Mice KW - Mice, Hairless KW - Exfoliatins -- toxicity KW - Epidermis -- drug effects KW - Skin -- enzymology KW - Skin -- drug effects KW - Skin -- pathology KW - Epidermis -- pathology KW - Epidermis -- enzymology KW - Hydroxymethylglutaryl CoA Reductases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80561841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Localization+and+regulation+of+epidermal+3-hydroxy-3-methylglutaryl-coenzyme+A+reductase+activity+by+barrier+requirements.&rft.au=Proksch%2C+E%3BElias%2C+P+M%3BFeingold%2C+K+R&rft.aulast=Proksch&rft.aufirst=E&rft.date=1991-04-24&rft.volume=1083&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-27 N1 - Date created - 1991-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini. AN - 80522107; 1708286 AB - The mechanisms regulating the net synthesis of digestive enzymes during short-term stimulation by agonists were examined in pancreatic acini isolated from the rat. Dispersed pancreatic acini were stimulated for up to 60 min with various concentrations of cholecystokinin octapeptide (CCK-OP), carbachol, A23187, 4 beta-phorbol 12-myristate 13-acetate (PMA). The effects of these agonists on net protein synthesis was determined by measuring the incorporation of [3H]leucine or [35S]methionine into protein. Carbachol, PMA, A23187 and concentrations of CCK-OP of 100 pM and greater caused inhibition of protein synthesis. Fluorography of [35S]methionine labeled acinar cell proteins separated by one-dimensional SDS-polyacrylamide gel electrophoresis demonstrated that the agonists inhibited the synthesis of the digestive enzymes. Northern blot analysis using cDNA probes revealed that CCK-OP, carbachol and PMA did not alter the cellular content of amylase, lipase and elastase mRNA. The protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) and staurosporine failed to reverse the inhibitory effects of CCK-OP, carbachol and PMA on protein synthesis. CCK-OP and PMA activated phospholipase A (PLA) which liberated lysophosphatidylcholine (LPC) and free fatty acids from membrane phosphatidylcholine. Exogenously added PLA2 (Naja naja venom) inhibited protein synthesis and increased LPC to a similar extent as CCK and PMA. The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation. JF - Biochimica et biophysica acta AU - Perkins, P S AU - Bahrami, L H AU - Lenhard, L W AU - Pandol, S J AD - Department of Medicine, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1991/04/17/ PY - 1991 DA - 1991 Apr 17 SP - 145 EP - 152 VL - 1092 IS - 2 SN - 0006-3002, 0006-3002 KW - Alkaloids KW - 0 KW - DNA Probes KW - Enzymes KW - Isoquinolines KW - Phosphatidylcholines KW - Piperazines KW - Calcimycin KW - 37H9VM9WZL KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Carbachol KW - 8Y164V895Y KW - Protein Kinase C KW - EC 2.7.11.13 KW - Lipase KW - EC 3.1.1.3 KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Amylases KW - EC 3.2.1.- KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Staurosporine KW - H88EPA0A3N KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Pancreatic Elastase -- biosynthesis KW - Electrophoresis, Polyacrylamide Gel KW - Phosphatidylcholines -- metabolism KW - Calcimycin -- pharmacology KW - Nucleic Acid Hybridization KW - Pancreatic Elastase -- genetics KW - Piperazines -- pharmacology KW - Sincalide -- pharmacology KW - Rats KW - Phospholipases A -- pharmacology KW - Enzyme Activation -- drug effects KW - Alkaloids -- pharmacology KW - Amylases -- biosynthesis KW - Phospholipases A -- metabolism KW - Amylases -- genetics KW - Rats, Inbred Strains KW - Isoquinolines -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Lipase -- biosynthesis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lipase -- genetics KW - Carbachol -- pharmacology KW - Pancreas -- enzymology KW - Enzymes -- biosynthesis KW - Pancreas -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80522107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Intracellular+mechanisms+involved+in+short-term+regulation+of+net+protein+synthesis+in+pancreatic+acini.&rft.au=Perkins%2C+P+S%3BBahrami%2C+L+H%3BLenhard%2C+L+W%3BPandol%2C+S+J&rft.aulast=Perkins&rft.aufirst=P&rft.date=1991-04-17&rft.volume=1092&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of transforming growth factor-beta and IL-1 alpha on prostaglandin synthesis in serum-deprived osteoblastic cells. AN - 80514147; 1707913 AB - We investigated the effects that the combination of IL-1 alpha and transforming growth factor-beta (TGF-beta) had on PGE2 production in a murine clonal osteoblastic cell line MC3T3-E1 and primary rat calvarial osteoblast-like cells. In serum-supplemented medium, IL-1 alpha was a potent stimulator of PGE2 production in MC3T3-E1 cells (50-fold increase with 0.1 ng/ml). TGF-beta (10 ng/ml) had only a small effect alone and no additional effect on IL-1 alpha-induced responses. In serum-deprived MC3T3-E1 cells, PGE2 responses to IL-1 alpha were either absent or markedly reduced. TGF-beta alone had small effects. However, simultaneous addition of TGF-beta with IL-1 alpha to MC3T3-E1 cells partially restored the ability of IL-1 alpha to generate a PGE2 response (10-fold increase in PGE2 with 0.1 ng/ml of both IL-1 alpha and TGF-beta). As with MC3T3-E1 cells, serum-deprived primary fetal rat calvarial osteoblastic cells also did not respond to IL-1 alpha, unless TGF-beta was present in the medium (sixfold increase in PGE2 with 0.1 ng/ml IL-1 alpha and 10 ng/ml TGF-beta). The synergistic effect of TGF-beta and IL-1 alpha was specific for PGE2 responses, because these factors did not synergistically affect cell proliferation, collagen and noncollagen protein synthesis, or alkaline phosphatase activity. The observed synergy was not associated with changes in the steady state cyclooxygenase (PGH synthase) mRNA levels. However, it did correlate with increased release of [3H]arachidonic acid from prelabeled serum-depleted MC3T3-E1 cells. Hence, the synergistic interactions of IL-1 alpha and TGF-beta on PGE2 appear to occur through an increase in the release of arachidonic acid substrate from phospholipid pools. These effects may be important for both normal bone turnover and the responses of bone to inflammatory and immune stimuli. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Marusić, A AU - Kalinowski, J F AU - Harrison, J R AU - Centrella, M AU - Raisz, L G AU - Lorenzo, J A AD - Veterans Administration Medical Center, Newington, CT 06111. Y1 - 1991/04/15/ PY - 1991 DA - 1991 Apr 15 SP - 2633 EP - 2638 VL - 146 IS - 8 SN - 0022-1767, 0022-1767 KW - Arachidonic Acids KW - 0 KW - Culture Media KW - Interleukin-1 KW - Transforming Growth Factor beta KW - Arachidonic Acid KW - 27YG812J1I KW - RNA KW - 63231-63-0 KW - Collagen KW - 9007-34-5 KW - DNA KW - 9007-49-2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Dose-Response Relationship, Drug KW - RNA -- analysis KW - Mice KW - Collagen -- biosynthesis KW - DNA -- biosynthesis KW - Arachidonic Acids -- biosynthesis KW - Cells, Cultured KW - Alkaline Phosphatase -- analysis KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Drug Synergism KW - Time Factors KW - Osteoblasts -- metabolism KW - Transforming Growth Factor beta -- pharmacology KW - Interleukin-1 -- pharmacology KW - Dinoprostone -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80514147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Effects+of+transforming+growth+factor-beta+and+IL-1+alpha+on+prostaglandin+synthesis+in+serum-deprived+osteoblastic+cells.&rft.au=Marusi%C4%87%2C+A%3BKalinowski%2C+J+F%3BHarrison%2C+J+R%3BCentrella%2C+M%3BRaisz%2C+L+G%3BLorenzo%2C+J+A&rft.aulast=Marusi%C4%87&rft.aufirst=A&rft.date=1991-04-15&rft.volume=146&rft.issue=8&rft.spage=2633&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-21 N1 - Date created - 1991-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hippocampal mossy fiber zinc deficit in mice genetically selected for ethanol withdrawal seizure susceptibility. AN - 80710020; 1860062 AB - Hippocampal mossy fiber zinc was examined in mice selectively bred for differences in susceptibility to handling-induced convulsions during ethanol withdrawal. The density of mossy fiber zinc in the CA3 stratum lucidum was significantly decreased in the duplicate lines of untreated withdrawal seizure prone (WSP) mice compared to untreated withdrawal seizure resistant (WSR) mice. Mossy fiber zinc densities in randomly bred control lines of mice (WSC) were intermediate to WSP and WSR mice. Serum, whole brain and whole hippocampal zinc were not significantly different between WSP and WSR mice, indicating that the reduction in the chelatable pool of hippocampal mossy fiber zinc was not a consequence of deficits in brain or whole body zinc nutrition. A highly significant correlation between hippocampal mossy fiber zinc density and handling-induced convulsion indices suggests that a reduction in mossy fiber zinc may be one contributing factor in the expression of seizure susceptibility in WSP mice. JF - Brain research AU - Feller, D J AU - Tso-Olivas, D Y AU - Savage, D D AD - Veterans Administration Medical Center, Portland, OR 97201. Y1 - 1991/04/05/ PY - 1991 DA - 1991 Apr 05 SP - 73 EP - 79 VL - 545 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Ethanol KW - 3K9958V90M KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Handling (Psychology) KW - Animals KW - Brain Chemistry KW - Mice, Neurologic Mutants KW - Organ Specificity KW - Mice KW - Zinc -- analysis KW - Substance Withdrawal Syndrome -- physiopathology KW - Seizures -- physiopathology KW - Hippocampus -- metabolism KW - Seizures -- genetics KW - Seizures -- pathology KW - Hippocampus -- pathology KW - Hippocampus -- chemistry KW - Zinc -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80710020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Hippocampal+mossy+fiber+zinc+deficit+in+mice+genetically+selected+for+ethanol+withdrawal+seizure+susceptibility.&rft.au=Feller%2C+D+J%3BTso-Olivas%2C+D+Y%3BSavage%2C+D+D&rft.aulast=Feller&rft.aufirst=D&rft.date=1991-04-05&rft.volume=545&rft.issue=1-2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-30 N1 - Date created - 1991-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypertrophic smooth muscle in the partially obstructed opossum esophagus. The model: histological and ultrastructural observations. AN - 85245637; pmid-2001825 AB - Obstruction is a complication of many esophageal diseases, but the morphological changes occurring in the obstructed esophagus are poorly understood. We developed a model of esophageal obstruction in the American opossum, Didelphis virginiana. A nonconstricting band around the gastroesophageal junction led to esophageal distention and tortuosity in the weeks following its placement. Despite a marked increase of the esophageal circumference, the esophageal wall was not thinned, and the circular muscle layer had actually increased its thickness. This was due to an increase in the size of individual smooth muscle cells with proportional increases in the cell surface area and volume. The electron density of hypertrophic smooth muscle cells varied much more than that of normal esophageal smooth muscle cells. As cell size increased, the tissue became more compact and the size of the extracellular space decreased. Also, the extracellular space was filled by an amorphous electron-dense material. Additional changes in the structure of hypertrophic smooth muscle cells included prominent intermediate filaments in the vicinity of thick filaments. There was no difference in the structure of the hypertrophic smooth muscle at 4 weeks and at 8 weeks after placement of the band. The morphological features described here resemble those seen in human esophageal spasm and achalasia of humans and could affect esophageal smooth muscle function. JF - Gastroenterology AU - Tung, H N AU - Schulze-Delrieu, K AU - Shirazi, S AU - Noel, S AU - Xia, Q AU - Cue, K AD - Department of Anatomy, Veterans Administration Medical Center, University of Iowa, Iowa City. PY - 1991 SP - 853 EP - 864 VL - 100 IS - 4 SN - 0016-5085, 0016-5085 KW - Esophagus KW - Hypertrophy KW - Muscle, Smooth KW - Esophageal Stenosis KW - Animal KW - Disease Models, Animal KW - Support, Non-U.S. Gov't KW - Female KW - Male KW - Opossums UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85245637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Hypertrophic+smooth+muscle+in+the+partially+obstructed+opossum+esophagus.+The+model%3A+histological+and+ultrastructural+observations.&rft.au=Tung%2C+H+N%3BSchulze-Delrieu%2C+K%3BShirazi%2C+S%3BNoel%2C+S%3BXia%2C+Q%3BCue%2C+K&rft.aulast=Tung&rft.aufirst=H&rft.date=1991-04-01&rft.volume=100&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Delayed subcapsular hematoma after percutaneous liver biopsy as a manifestation of warfarin toxicity. AN - 85225197; pmid-1849346 AB - Guidelines for the management of patients receiving chronic anticoagulation therapy who require liver biopsy are not clearly defined. In patients with normal coagulation, liver biopsy is a relatively safe procedure with a morbidity of less than 0.1% and a mortality of less than 0.01%. We report a patient with a prosthetic aortic valve who developed a large subcapsular hematoma 12 days after a percutaneous liver biopsy as a consequence of warfarin toxicity. Based on the experience with this patient, reinstitution of anticoagulant therapy should be avoided for at least 72 h after a percutaneous liver biopsy. Intravenous heparin should be resumed first, and warfarin added if no bleeding has occurred after an additional 48-72 h. The prothrombin time should be maintained at 1.5 times the baseline. JF - The American Journal of Gastroenterology AU - Scott, D A AU - Netchvolodoff, C V AU - Bacon, B R AD - Department of Medicine, Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana. PY - 1991 SP - 503 EP - 505 VL - 86 IS - 4 SN - 0002-9270, 0002-9270 KW - Liver Neoplasms KW - Hematoma KW - Liver Diseases KW - Carcinoma, Hepatocellular KW - Human KW - Middle Age KW - Case Report KW - Warfarin KW - Biopsy, Needle KW - Prothrombin Time KW - Time Factors KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Delayed+subcapsular+hematoma+after+percutaneous+liver+biopsy+as+a+manifestation+of+warfarin+toxicity.&rft.au=Scott%2C+D+A%3BNetchvolodoff%2C+C+V%3BBacon%2C+B+R&rft.aulast=Scott&rft.aufirst=D&rft.date=1991-04-01&rft.volume=86&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy. AN - 85223492; pmid-1901443 AB - Valproic acid has been implicated in at least 100 cases of fatal acute liver failure. Most cases have occurred in patients less than 10 yr old; however, at least seven have involved adults. Microvesicular steatosis has been uniformly observed, but its incidence in less severe liver disease and in asymptomatic patients receiving valproate is unknown. We report two patients receiving maintenance valproate, one with resolving acute hepatitis C and the other with chronic persistent hepatitis C, with incidental microvesicular steatosis demonstrated on oil-red O stains. We conclude that microvesicular steatosis does not necessarily signify hepatotoxicity in patients on chronic valproic acid, and should not lead to discontinuation of the drug until other causes of acute or chronic liver disease have been excluded. JF - The American Journal of Gastroenterology AU - Scott, D A AU - Gholson, C F AU - Netchvolodoff, C V AU - Ray, M AU - Gonzalez, E AU - Bacon, B R AD - Department of Medicine, Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana. PY - 1991 SP - 500 EP - 502 VL - 86 IS - 4 SN - 0002-9270, 0002-9270 KW - Hepatitis, Chronic KW - Human KW - Adult KW - Seizures KW - Case Report KW - Fatty Liver KW - Hepatitis C KW - Valproic Acid KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Incidental+microvesicular+steatosis+due+to+valproic+acid+anticonvulsant+therapy.&rft.au=Scott%2C+D+A%3BGholson%2C+C+F%3BNetchvolodoff%2C+C+V%3BRay%2C+M%3BGonzalez%2C+E%3BBacon%2C+B+R&rft.aulast=Scott&rft.aufirst=D&rft.date=1991-04-01&rft.volume=86&rft.issue=4&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Facial nerve and medially invasive petrous bone cholesteatomas. AN - 85176991; pmid-2018289 AB - Eight patients with extensive petrous bone cholesteatomas that invaded the labyrinth and fallopian canal are presented. The eight cases are added to a tabulation of prior literature reports to elucidate concepts of routes of extension of medially invasive temporal bone cholesteatoma. Medially invasive petrous bone cholesteatoma develops insidiously, often without symptoms other than facial palsy and/or unilateral deafness. Typically, a history of chronic ear disease can be obtained. While hearing is unlikely to be preserved in this group of patients, facial nerve function can usually be preserved, and a facial nerve graft was not necessary in our series. Acute facial nerve palsy or facial nerve paresis progressing to palsy in patients with a history of chronic ear disease should be studied radiographically for petrous bone cholesteatoma, even if there is no physical evidence of cholesteatoma. JF - The Annals of Otology, Rhinology, and Laryngology AU - Bartels, L J AD - Department of Surgery, University of South Florida, James Haley Veterans Administration Hospital, Tampa 33612. PY - 1991 SP - 308 EP - 316 VL - 100 IS - 4 Pt 1 SN - 0003-4894, 0003-4894 KW - Humans KW - Adult KW - Petrous Bone KW - Aged KW - Cholesteatoma KW - Middle Aged KW - Ear Diseases KW - Facial Paralysis KW - Female KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85176991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Facial+nerve+and+medially+invasive+petrous+bone+cholesteatomas.&rft.au=Bartels%2C+L+J&rft.aulast=Bartels&rft.aufirst=L&rft.date=1991-04-01&rft.volume=100&rft.issue=4+Pt+1&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Aluminum alters calcium influx and efflux from bone in vitro. AN - 80617807; 2051717 AB - Aluminum retention can cause osteomalacia and adynamic lesions of bone in patients undergoing long-term dialysis. It is not known, however, whether aluminum inhibits the mineralization of bone directly or whether alterations in osteoblastic function mediate this response. To examine this issue, the uptake of 45Ca by 14-day embryonic chick calvaria was measured in vitro. Comparative studies were done in living and devitalized tissues to evaluate the role of bone cells in aluminum-related changes in 45Ca uptake. Aluminum was added to serum-free media as the citrate complex, and paired hemicalvaria maintained in equimolar sodium citrate served as controls. Aluminum citrate decreased the uptake of 45Ca into bone during 24 hour incubations to 76 +/- 3% and 38 +/- 2% (x +/- SD) of control values at 10 microM and 100 microM aluminum, respectively. No change in 45Ca uptake was observed at the end of four hour incubations with 100 microM aluminum citrate, whereas 45Ca uptake decreased from 356 +/- 48 to 266 +/- 36 cpm/micrograms bone, P less than 0.05, at eight hours and from 327 +/- 22 to 269 +/- 41 cpm/micrograms bone, P less than 0.05, at 24 hours. The inhibitory effects of 10 microM and 100 microM aluminum on 45Ca uptake were eliminated, however, in devitalized tissues, and reductions in 45Ca uptake during incubations with aluminum were markedly attenuated by lowering the media phosphorus level from 4.0 mM to 2.0 mM.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Kidney international AU - Goodman, W G AU - O'Connor, J AD - Medical Service, Sepulveda Veterans Administration Medical Center, California. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 602 EP - 607 VL - 39 IS - 4 SN - 0085-2538, 0085-2538 KW - Aluminum KW - CPD4NFA903 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Osteoblasts -- metabolism KW - Osteoblasts -- drug effects KW - Biological Transport, Active -- drug effects KW - Animals KW - Chick Embryo KW - In Vitro Techniques KW - Calcium -- metabolism KW - Bone and Bones -- drug effects KW - Aluminum -- toxicity KW - Bone and Bones -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80617807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Aluminum+alters+calcium+influx+and+efflux+from+bone+in+vitro.&rft.au=Goodman%2C+W+G%3BO%27Connor%2C+J&rft.aulast=Goodman&rft.aufirst=W&rft.date=1991-04-01&rft.volume=39&rft.issue=4&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic inhibition potentiates oxidant injury. AN - 80526949; 2020185 AB - Toxic oxygen species have been implicated as important mediators of injury after reperfusion of an ischemic organ. The aim of this study was to determine if prior metabolic inhibition, such as that which occurs during ischemia, potentiates oxidant injury in vitro. Bovine pulmonary artery endothelial cells were metabolically inhibited for various periods of time with or without the mitochondrial inhibitor oligomycin (650 nM). The cells were rescued from metabolic inhibition by a wash step and subsequent addition of 5.5 mM glucose. At the same time that metabolic inhibition was relieved the cells were subjected to doses of H2O2 ranging from 0 to 100 microM. ATP levels were monitored over a 2-hr time course after rescue from metabolic inhibition by the luciferin-luciferase assay. Cell viability at 2 hr after relief of metabolic inhibition was assessed by trypan blue exclusion. Intracellular pH during metabolic inhibition was determined with the fluorescent dye 2',7'-bis-(2-carboxyethyl)-5(and-6) carboxyfluorescein tetraacetomethoxymethyl ester. H2O2 consumption, a measure of H2O2 scavenging capability, was determined by a fluorescent assay. The viability and ATP levels of cells not subjected to metabolic inhibition were unaffected by these low concentrations of H2O2. Cells metabolically inhibited with glucose depletion and oligomycin were exquisitely sensitive to H2O2. Cells that were only deprived of glucose demonstrated no potentiation of injury, while cells subjected to mitochondrial inhibition with oligomycin alone also showed significant potentiation of oxidant injury. H2O2 consumption was not affected by metabolic inhibition. Conditions associated with mitochondrial inhibition consistently resulted in a decrease in intracellular pH. These experiments suggest that a synergism exists between metabolic inhibition and subsequent oxidant exposure.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of surgical research AU - Delius, R E AU - Hinshaw, D B AD - Surgical Service, Ann Arbor Veterans Administration Medical Center, MI 48105. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 314 EP - 322 VL - 50 IS - 4 SN - 0022-4804, 0022-4804 KW - Oligomycins KW - 0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glucose KW - IY9XDZ35W2 KW - Potassium Cyanide KW - MQD255M2ZO KW - Index Medicus KW - Animals KW - Cattle KW - Endothelium, Vascular -- metabolism KW - Hydrogen-Ion Concentration KW - Hydrogen Peroxide -- metabolism KW - Glucose -- metabolism KW - In Vitro Techniques KW - Adenosine Triphosphate -- metabolism KW - Oligomycins -- pharmacology KW - Models, Biological KW - Potassium Cyanide -- pharmacology KW - Cell Survival KW - Reperfusion Injury -- metabolism KW - Ischemia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80526949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Metabolic+inhibition+potentiates+oxidant+injury.&rft.au=Delius%2C+R+E%3BHinshaw%2C+D+B&rft.aulast=Delius&rft.aufirst=R&rft.date=1991-04-01&rft.volume=50&rft.issue=4&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of surfactant subtype convertase in radiation model of adult respiratory distress syndrome. AN - 80518824; 2018151 AB - The accompanying paper [Am. J. Physiol. 260 (Lung Cell. Mol. Physiol. 4): L302-L310, 1991] showed that in the radiation pneumonitis model of adult respiratory distress syndrome (ARDS) there was an excess of the proximate, higher buoyant density subtypes of alveolar surfactant, and a decrease in the light buoyant density form. Because the surfactant subtypes normally evolve from the former to the latter a delay in the alveolar metabolism of surfactant could explain this disproportion. Three possible mechanisms of a delay in surfactant metabolism in radiation pneumonitis were explored using an in vitro model of surfactant subtype metabolism called "cycling". The first was that the surfactant of mice with radiation pneumonitis was intrinsically less capable of conversion to the light subtype. It was found, however, that the proximate forms of surfactant of mice with radiation pneumonitis were as capable of generating light subtype as those of control mice. The second was that there was a deficit in the serine protease activity, called "convertase", that mediates the conversion. But it was found that lungs of mice with radiation pneumonitis released convertase activity to the same extent as control lungs. The third was that an inhibitor of convertase activity was present in the alveoli. It was found that the alveolar lavage fluid of mice with radiation pneumonitis inhibited the conversion of exogenous surfactant by exogenous convertase. Moreover, it contained an 18-fold excess of antiprotease activity. The present data are interpreted as suggesting that an inhibitor in the alveolar space is responsible for the delay in surfactant subtype metabolism in radiation pneumonitis, resulting in the disproportion of surfactant subtypes in radiation pneumonitis.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of physiology AU - Gross, N J AD - Medical Service, Hines Veterans Administration Hospital 60141. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - L311 EP - L317 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Pulmonary Surfactants KW - 0 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - surfactant subtype convertase KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Therapeutic Irrigation KW - Mice KW - Female KW - Respiratory Distress Syndrome, Adult -- metabolism KW - Pulmonary Surfactants -- metabolism KW - Pulmonary Surfactants -- isolation & purification KW - Radiation Injuries, Experimental -- metabolism KW - Serine Endopeptidases -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Pulmonary Surfactants -- classification KW - Respiratory Distress Syndrome, Adult -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80518824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Inhibition+of+surfactant+subtype+convertase+in+radiation+model+of+adult+respiratory+distress+syndrome.&rft.au=Gross%2C+N+J&rft.aulast=Gross&rft.aufirst=N&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=L311&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surfactant subtypes in experimental lung damage: radiation pneumonitis. AN - 80516427; 2018150 AB - Radiation pneumonitis, a chronic form of adult respiratory distress syndrome (ARDS), is known to be associated with physiological and biophysical abnormalities of the surface element of the lungs suggesting an impairment of the surfactant system. The alveolar surfactant of mice with radiation pneumonitis was fractionated into subtypes on continuous sucrose density gradients to examine their relative amounts, composition, ultrastructure, surface activity, and turnover kinetics. The total phospholipid and protein contents of the alveolar lavage were increased. The proportions of high buoyant density subtypes (normally surface active) were increased about twofold and that of the low buoyant density subtype (not surface active) was decreased or absent. The buoyant densities, ultrastructure, and phospholipid compositions of the major surfactant subtypes were not significantly altered. The surface activity of the normally surface-active subtypes, when purified free of extraneous material, was close to those of normal controls. Turnover studies of the kinetics of surfactant subtype phospholipids suggested increased secretion of surfactant but a delay in the conversion of the heavier subtypes into their low-density product. Most of the heavier material appeared not to enter the lighter pool, in contrast to findings in control mice. It is concluded that in this form of ARDS the surfactant subtypes are qualitatively normal but that their surface activity is impaired, presumably by extraneous material in the alveoli, and that proportions of surfactant subtypes are radically altered by a combination of increased synthesis and decreased metabolism of the heavier subtypes. JF - The American journal of physiology AU - Gross, N J AD - Medical Service, Hines Veterans Administration Hospital 60141. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - L302 EP - L310 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Cobalt Radioisotopes KW - 0 KW - Phospholipids KW - Pulmonary Surfactants KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Phospholipids -- radiation effects KW - Phospholipids -- isolation & purification KW - Therapeutic Irrigation KW - Phospholipids -- classification KW - Disease Models, Animal KW - Microscopy, Electron KW - Mice KW - Female KW - Radiation Injuries, Experimental -- pathology KW - Pulmonary Surfactants -- isolation & purification KW - Pulmonary Alveoli -- ultrastructure KW - Pulmonary Alveoli -- chemistry KW - Lung -- ultrastructure KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Respiratory Distress Syndrome, Adult -- pathology KW - Lung -- pathology KW - Radiation Injuries, Experimental -- physiopathology KW - Lung -- physiopathology KW - Respiratory Distress Syndrome, Adult -- etiology KW - Pulmonary Alveoli -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80516427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Surfactant+subtypes+in+experimental+lung+damage%3A+radiation+pneumonitis.&rft.au=Gross%2C+N+J&rft.aulast=Gross&rft.aufirst=N&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=L302&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transferrin enhances the antiproliferative effect of aluminum on osteoblast-like cells. AN - 80515966; 2018119 AB - Aluminum (Al) retention in the body can cause metabolic bone disease. This disorder is characterized by reductions in the number of osteoblasts, a feature that suggests a disturbance in bone cell proliferation or differentiation. Because Al as well as iron (Fe) can bind to transferrin (TF) in plasma, the role of TF as a modifier of osteoblast proliferation was examined in UMR-106-01 osteoblast-like cells by measuring the incorporation of tritiated thymidine ([3H]-TdR) into DNA (counts.min-1.microgram cell protein-1, means +/- SE) during 48-h incubations in serum-free medium (SFM). In the absence of TF, DNA synthesis decreased when media levels of Al exceeded 6-10 microM. The mitogenic response to physiological levels of unsaturated TF (apo-TF) was attenuated however during incubations with TF that was partially saturated with Al (Al-TF). A similar inhibitory response was seen in cells incubated with the antiproliferative agent gallium (Ga) when added to SFM as partially saturated Ga-TF. TF produced a shift to the left in the inhibitory dose-response curve to Al in osteoblast-like cells; thus, DNA synthesis decreased at substantially lower media concentrations of Al in cells grown in SFM containing partially saturated Al-TF. The results indicate that TF is an important determinant of the inhibitory effect of Al on DNA synthesis by osteoblast-like cells at the micromolar levels of Al that can occur in plasma in vivo. JF - The American journal of physiology AU - Kasai, K AU - Hori, M T AU - Goodman, W G AD - Medical Service, Sepulveda Veterans Administration Medical Center 91343. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - E537 EP - E543 VL - 260 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Apoproteins KW - 0 KW - Citrates KW - Transferrin KW - apotransferrin KW - Tritium KW - 10028-17-8 KW - Citric Acid KW - 2968PHW8QP KW - Gallium KW - CH46OC8YV4 KW - Aluminum KW - CPD4NFA903 KW - Iron KW - E1UOL152H7 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Animals KW - Apoproteins -- pharmacology KW - Iron -- pharmacology KW - Osteosarcoma KW - Rats KW - Thymidine -- metabolism KW - Gallium -- pharmacology KW - Kinetics KW - Sarcoma, Experimental KW - Drug Synergism KW - Cell Line KW - Osteoblasts -- drug effects KW - Aluminum -- pharmacology KW - Cell Division -- drug effects KW - Transferrin -- pharmacology KW - Citrates -- pharmacology KW - DNA Replication -- drug effects KW - Osteoblasts -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80515966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Transferrin+enhances+the+antiproliferative+effect+of+aluminum+on+osteoblast-like+cells.&rft.au=Kasai%2C+K%3BHori%2C+M+T%3BGoodman%2C+W+G&rft.aulast=Kasai&rft.aufirst=K&rft.date=1991-04-01&rft.volume=260&rft.issue=4+Pt+1&rft.spage=E537&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory gastropathy: from theory to practice. AN - 80499013; 2012116 AB - The success of nonsteroidal anti-inflammatory drugs in managing joint inflammation and pain has come at the cost of impressive side effects, particularly in the gastrointestinal tract. This manuscript reviews the magnitude of the problem, the risk factors, and presentation of nonsteroidal gastropathy. It also presents some points in the prevention and management of the disorder. JF - The American journal of the medical sciences AU - Balaa, M A AD - Veterans Administration Medical Center, Jackson, Mississippi. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 272 EP - 276 VL - 301 IS - 4 SN - 0002-9629, 0002-9629 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Prostaglandin Antagonists KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Age Factors KW - Prostaglandin Antagonists -- adverse effects KW - Humans KW - Gastric Mucosa -- drug effects KW - Stomach Diseases -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Stomach Diseases -- therapy KW - Stomach Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80499013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Nonsteroidal+anti-inflammatory+gastropathy%3A+from+theory+to+practice.&rft.au=Balaa%2C+M+A&rft.aulast=Balaa&rft.aufirst=M&rft.date=1991-04-01&rft.volume=301&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-03 N1 - Date created - 1991-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diphenylhydantoin-induced hypogammaglobulinemia in a patient infected with human immunodeficiency virus. AN - 80498859; 2012095 AB - A case is reported of reversible panhypogammaglobulinemia in a human immunodeficiency virus (HIV)-infected patient. Onset and resolution were temporally correlated with initiation and termination, respectively, of diphenylhydantoin therapy for a possible seizure. A rapid alteration in peripheral T-cell subpopulations was also noted in association with diphenylhydantoin administration. This case is compared with previous reports of diphenylhydantoin-associated hypogammaglobulinemia in non-HIV-infected patients. In addition, the case is discussed with regard to possible deleterious effects associated with the use of diphenylhydantoin as therapy for HIV-associated seizures or as an antiretroviral agent in HIV disease. JF - The American journal of medicine AU - Britigan, B E AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 524 EP - 527 VL - 90 IS - 4 SN - 0002-9343, 0002-9343 KW - Phenytoin KW - 6158TKW0C5 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Hepatitis B -- complications KW - Seizures -- complications KW - Humans KW - Adult KW - Seizures -- drug therapy KW - Homosexuality KW - Liver Function Tests KW - Male KW - Agammaglobulinemia -- chemically induced KW - Agammaglobulinemia -- physiopathology KW - Agammaglobulinemia -- complications KW - Phenytoin -- adverse effects KW - HIV Seropositivity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80498859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Diphenylhydantoin-induced+hypogammaglobulinemia+in+a+patient+infected+with+human+immunodeficiency+virus.&rft.au=Britigan%2C+B+E&rft.aulast=Britigan&rft.aufirst=B&rft.date=1991-04-01&rft.volume=90&rft.issue=4&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-09 N1 - Date created - 1991-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic use of acebutolol in the treatment of cardiac arrhythmias. AN - 80492160; 2008843 JF - American heart journal AU - O'Reilly, M AD - Cardiology Section, Veterans Administration Medical Center, Wilkes-Barre, PA 18711. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 1185 EP - 1193 VL - 121 IS - 4 Pt 1 SN - 0002-8703, 0002-8703 KW - Acebutolol KW - 67P356D8GH KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Chronic Disease KW - Acebutolol -- administration & dosage KW - Arrhythmias, Cardiac -- drug therapy KW - Acebutolol -- therapeutic use KW - Acebutolol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80492160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Chronic+use+of+acebutolol+in+the+treatment+of+cardiac+arrhythmias.&rft.au=O%27Reilly%2C+M&rft.aulast=O%27Reilly&rft.aufirst=M&rft.date=1991-04-01&rft.volume=121&rft.issue=4+Pt+1&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-02 N1 - Date created - 1991-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - COPD exacerbation associated with a skin rash. AN - 80489697; 1826252 JF - Chest AU - Marshall, J AU - Altman, D AU - Lauber, M AU - Baylor, P AD - Veterans Administration Medical Center, Fresno, CA. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 1016 EP - 1017 VL - 99 IS - 4 SN - 0012-3692, 0012-3692 KW - Cimetidine KW - 80061L1WGD KW - Abridged Index Medicus KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Aged KW - Cimetidine -- adverse effects KW - Male KW - Drug Eruptions -- diagnosis KW - Strongyloidiasis -- complications KW - Strongyloidiasis -- diagnosis KW - Larva Migrans -- diagnosis KW - Lung Diseases, Obstructive -- complications KW - Larva Migrans -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80489697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=COPD+exacerbation+associated+with+a+skin+rash.&rft.au=Marshall%2C+J%3BAltman%2C+D%3BLauber%2C+M%3BBaylor%2C+P&rft.aulast=Marshall&rft.aufirst=J&rft.date=1991-04-01&rft.volume=99&rft.issue=4&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-06 N1 - Date created - 1991-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Precautions prevent spread of Creutzfeldt-Jakob disease. AN - 72050039; 1831471 AB - Currently some experts are predicting the incidence of the rare yet rapidly fatal Creutzfeldt-Jakob disease (CJD) is on the rise. Worldwide, there is about one case per million people per year, but iatrogenic transmission is increasing. There have been documented cases of CJD transmission through corneal transplants, stereotactic equipment, human growth hormone and dura mater grafts. In addition, there are now three cases of laboratory workers with CJD from exposure in the workplace. No known treatment alters the relentless course of CJD and there is no vaccine. In every rapidly progressive unexplained dementia CJD must remain a diagnostic possibility. Because the etiologic agent is virulent, definition of necessary precautions for staff members associated with such patients is needed. Thus it is imperative medical personnel be well trained in the practice of universal precautions. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Mocsny, N AD - Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 116 EP - 119 VL - 23 IS - 2 SN - 0888-0395, 0888-0395 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Nursing Staff, Hospital KW - Occupational Diseases -- prevention & control KW - Creutzfeldt-Jakob Syndrome -- transmission KW - Occupational Diseases -- etiology KW - Creutzfeldt-Jakob Syndrome -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72050039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Precautions+prevent+spread+of+Creutzfeldt-Jakob+disease.&rft.au=Mocsny%2C+N&rft.aulast=Mocsny&rft.aufirst=N&rft.date=1991-04-01&rft.volume=23&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-26 N1 - Date created - 1991-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sexual Interest, Activity, and Satisfaction among Male Nursing Home Residents AN - 61236201; 91X9422 AB - Structured interviews completed with 61 male residents, 30 of whom had partners, of a Veterans Affairs Nursing Home are used to investigate sexual interest, preference, activity levels, satisfaction, & distress. Sexual interest was significantly higher among those with partners, although those without partners reported that their interest would have been higher if they had a sexual partner. Sexual preference was strongly in favor of vaginal intercourse, regardless of the presence or absence of a partner. Among those with partners, coitus was reported to occur at least monthly by 17%, & other forms of sexual activity (eg, hugging, kissing) were practiced at least monthly by 73%. Sexual satisfaction was high, & distress with relative sexual inactivity was remarkably low. Findings reveal that age, functional status, & intercourse frequency correlate positively with sexual satisfaction, whereas marital status, cognitive function, libido, & frequency of kissing were positive correlates of sexual distress. Institutionalized elderly males remain sexually interested, especially in coitus, & may benefit from counseling & home visits when a partner is available. 1 Table, 7 References. Adapted from the source document. JF - Archives of Sexual Behavior AU - Mulligan, Thomas AU - Palguta, Robert F, Jr AD - Veterans Administration Medical Center, Broad Rock Rd Richmond VA 23249 Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 199 EP - 204 VL - 20 IS - 2 SN - 0004-0002, 0004-0002 KW - sexual interest/preference/activity/satisfaction/distress, male Veterans Affairs Nursing Home residents KW - interviews KW - Sexual Behavior KW - Satisfaction KW - Males KW - Elderly KW - Nursing Homes KW - article KW - 2143: social problems and social welfare; social gerontology KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61236201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Sexual+Interest%2C+Activity%2C+and+Satisfaction+among+Male+Nursing+Home+Residents&rft.au=Mulligan%2C+Thomas%3BPalguta%2C+Robert+F%2C+Jr&rft.aulast=Mulligan&rft.aufirst=Thomas&rft.date=1991-04-01&rft.volume=20&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASXBA8 N1 - SubjectsTermNotLitGenreText - Elderly; Males; Nursing Homes; Sexual Behavior; Satisfaction ER - TY - JOUR T1 - Alternate Form of the California Verbal Learning Test: Development and Reliability AN - 58219944; 9202110 AB - A parallel form of the California Verbal Learning Test (CVLT) was developed & compared with the original (N = 41 normal adults). The two CVLT forms yielded equivalent mean scores for the 19 learning & memory variables analyzed. Order of administration of the two forms did not produce any significant practice effects. They both yielded almost identical relationships between overall memory performance & age & education. Sixteen of the variables resulted in significant alternate form reliability coefficients. Coefficients for the traditional recall measures were particularly robust & higher than those reported for other commonly used clinical memory tests. 2 Tables, 35 References. Adapted from the source document JF - The Clinical Neuropsychologist AU - Delis, Dean C AU - McKee, Richard AU - Massman, Paul J AU - Kramer, Joel H AU - Kaplan, Edith AU - Gettman, Dennis AD - Psychology Service Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 154 EP - 162 VL - 5 IS - 2 SN - 1385-4046, 1385-4046 KW - California Verbal Learning Test parallel alternative form development/comparison/reliability KW - empirical testing KW - normal adults KW - Retention (Memory) (73150) KW - Test Validity and Reliability (88800) KW - Adults (00600) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58219944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Alternate+Form+of+the+California+Verbal+Learning+Test%3A+Development+and+Reliability&rft.au=Delis%2C+Dean+C%3BMcKee%2C+Richard%3BMassman%2C+Paul+J%3BKramer%2C+Joel+H%3BKaplan%2C+Edith%3BGettman%2C+Dennis&rft.aulast=Delis&rft.aufirst=Dean&rft.date=1991-04-01&rft.volume=5&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Test Validity and Reliability (88800); Adults (00600); Retention (Memory) (73150) ER - TY - JOUR T1 - Diminished glucose transport in Alzheimer's disease: dynamic PET studies. AN - 85274497; pmid-1997504 AB - Dynamic positron emission tomography with [18F]fluorodeoxyglucose was used in six patients with Alzheimer's disease (AD) and seven healthy age-matched control subjects to estimate the kinetic parameters K1*, k2*, and k3* that describe glucose transport and phosphorylation. A high-resolution tomograph was used to acquire brain uptake data in one tomographic plane, and a radial artery catheter connected to a plastic scintillator was used to acquire arterial input data. A nonlinear iterative least-squares fitting procedure that included terms for the vascular fraction and time delay to the peripheral sampling site was used to fit a three-compartment model to the brain data. Regions studied included frontal, temporal, occipital, and the entire cortex and subcortical white matter. The values obtained for the individual rate constants and regional CMRglc (rCMRglc; calculated using regional values of the rate constants) were higher than those reported previously. A significant (p less than 0.05) decrease was found in K1* in frontal and temporal cortex in the AD patients compared with the controls, with values of 0.157 and 0.161 ml/g/min in frontal and temporal cortex, respectively, of controls and 0.127 and 0.126 ml/g/min in frontal and temporal cortex of the AD patients. rCMRglc was also significantly (p less than 0.02) lower in the AD patients than controls in all cortical brain regions. Lower values of k3* were found in all brain regions in the AD patients, although these were not statistically significant. These findings provide evidence of an in vivo abnormality of forward glucose transport in AD.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of Cerebral Blood Flow and Metabolism AU - Jagust, W J AU - Seab, J P AU - Huesman, R H AU - Valk, P E AU - Mathis, C A AU - Reed, B R AU - Coxson, P G AU - Budinger, T F AD - Department of Neurology, Martinez Veterans Administration Medical Center, California. PY - 1991 SP - 323 EP - 330 VL - 11 IS - 2 SN - 0271-678X, 0271-678X KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Alzheimer Disease KW - Biological Transport KW - Brain KW - Glucose KW - Aged KW - Cerebral Cortex KW - Frontal Lobe KW - Phosphorylation KW - Fludeoxyglucose F 18 KW - Kinetics KW - Fluorine Radioisotopes KW - Temporal Lobe KW - Middle Age KW - Deoxyglucose KW - Support, U.S. Gov't, Non-P.H.S. KW - Tomography, Emission-Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85274497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Diminished+glucose+transport+in+Alzheimer%27s+disease%3A+dynamic+PET+studies.&rft.au=Jagust%2C+W+J%3BSeab%2C+J+P%3BHuesman%2C+R+H%3BValk%2C+P+E%3BMathis%2C+C+A%3BReed%2C+B+R%3BCoxson%2C+P+G%3BBudinger%2C+T+F&rft.aulast=Jagust&rft.aufirst=W&rft.date=1991-03-01&rft.volume=11&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Epithelioid angiosarcoma of the adrenal gland associated with chronic arsenical intoxication? AN - 80672088; 2068012 AB - Epithelioid angiosarcoma is a rare tumor quite recently described. There is no accurate epidemiological study of this tumor. Among the internal organs, the liver is the one most frequently affected with angiosarcoma while there is no reference to the adrenal gland as a primary site. It is well known that the direct exposure to arsenicals (especially of vineyard cultivators) may be an important causative factor in the pathogenesis of the disease. A 59-year-old male vineyard cultivator with an epithelioid angiosarcoma of the right adrenal gland is described. The histologic characteristics as well as the immunohistochemical profile of the tumor are presented and the literature is briefly reviewed. JF - Pathology, research and practice AU - Livaditou, A AU - Alexiou, G AU - Floros, D AU - Filippidis, T AU - Dosios, T AU - Bays, D AD - Air Force and Veterans Administration General Hospital, Athens, Greece. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 284 EP - 289 VL - 187 IS - 2-3 SN - 0344-0338, 0344-0338 KW - Insecticides KW - 0 KW - Index Medicus KW - Humans KW - Tomography, X-Ray Computed KW - Middle Aged KW - Epithelium -- pathology KW - Male KW - Insecticides -- poisoning KW - Arsenic Poisoning KW - Agricultural Workers' Diseases -- chemically induced KW - Adrenal Gland Neoplasms -- chemically induced KW - Hemangiosarcoma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80672088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathology%2C+research+and+practice&rft.atitle=Epithelioid+angiosarcoma+of+the+adrenal+gland+associated+with+chronic+arsenical+intoxication%3F&rft.au=Livaditou%2C+A%3BAlexiou%2C+G%3BFloros%2C+D%3BFilippidis%2C+T%3BDosios%2C+T%3BBays%2C+D&rft.aulast=Livaditou&rft.aufirst=A&rft.date=1991-03-01&rft.volume=187&rft.issue=2-3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Pathology%2C+research+and+practice&rft.issn=03440338&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-15 N1 - Date created - 1991-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heparin-induced hyperkalemia. AN - 80669267; 2067368 JF - Journal of the Tennessee Medical Association AU - Margolies, G AD - Nashville Veterans Administration Hospital. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 126 VL - 84 IS - 3 SN - 0040-3318, 0040-3318 KW - Heparin KW - 9005-49-6 KW - Aspirin KW - R16CO5Y76E KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Drug Therapy, Combination KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Humans KW - Potassium -- blood KW - Aged KW - Male KW - Cerebral Infarction -- blood KW - Hyperkalemia -- blood KW - Heparin -- administration & dosage KW - Cerebral Infarction -- drug therapy KW - Hyperkalemia -- chemically induced KW - Heparin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80669267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Tennessee+Medical+Association&rft.atitle=Heparin-induced+hyperkalemia.&rft.au=Margolies%2C+G&rft.aulast=Margolies&rft.aufirst=G&rft.date=1991-03-01&rft.volume=84&rft.issue=3&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Tennessee+Medical+Association&rft.issn=00403318&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-09 N1 - Date created - 1991-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol and drug abuse prevention in adolescents. AN - 80648004; 2058809 JF - Alcoholism, clinical and experimental research AU - Gallant, D M AU - Head-Dunham, R AD - Department of Psychiatry and Neurology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 308 VL - 15 IS - 2 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Self Concept KW - Adaptation, Psychological KW - Risk Factors KW - Humans KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Health Education -- methods KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80648004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol+and+drug+abuse+prevention+in+adolescents.&rft.au=Gallant%2C+D+M%3BHead-Dunham%2C+R&rft.aulast=Gallant&rft.aufirst=D&rft.date=1991-03-01&rft.volume=15&rft.issue=2&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-29 N1 - Date created - 1991-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Scanning electron microscopic analysis of mineral fiber content of lung tissue in the evaluation of diffuse pulmonary fibrosis. AN - 80624641; 2052931 AB - The mineral fiber content of lung parenchyma in 24 cases of diffuse pulmonary fibrosis of unknown cause was determined by scanning electron microscopy and compared with that of 36 autopsy cases of histologically confirmed asbestosis and 20 autopsy cases of patients with normal lungs. Fibers were isolated from the lung using a hypochlorite digestion technique and collected on the surface of a polycarbonate filter. In addition, the types of fibers present (asbestos vs. other mineral fibers) were determined by energy dispersive x-ray analysis (EDXA). When the histologic grade of fibrosis in the cases of asbestosis was compared with the uncoated fiber content by means of linear regression analysis, it was determined that the fiber content of the 24 cases of diffuse pulmonary fibrosis of unknown cause was below the 95% confidence limit for asbestosis in every instance. Furthermore, the majority of fibers analyzed by EDXA were not asbestos in the cases with diffuse pulmonary fibrosis of unknown cause, whereas more than 90% of the fibers from the asbestosis cases were commercial amphiboles (amosite or crocidolite). It was concluded that most patients with advanced pulmonary fibrosis whose tissue samples do not meet histologic criteria for asbestosis do not have asbestos-induced fibrosis, even though there may be some history of exposure to asbestos. In such cases, scanning electron microscopic analysis of mineral fiber content and EDXA of the types of fibers present often provide useful information with regard to the correct classification of these cases. JF - Scanning microscopy AU - Roggli, V L AD - Department of Pathology, Durham Veterans Administration Medical Center, North Carolina 27710. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 71 EP - 80; discussion 80-3 VL - 5 IS - 1 SN - 0891-7035, 0891-7035 KW - Minerals KW - 0 KW - Index Medicus KW - Regression Analysis KW - Aged, 80 and over KW - Humans KW - Asbestosis -- pathology KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Microscopy, Electron, Scanning KW - Pulmonary Fibrosis -- pathology KW - Lung -- ultrastructure KW - Minerals -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80624641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+microscopy&rft.atitle=Scanning+electron+microscopic+analysis+of+mineral+fiber+content+of+lung+tissue+in+the+evaluation+of+diffuse+pulmonary+fibrosis.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1991-03-01&rft.volume=5&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Scanning+microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug treatment of schizophrenia. Overview of recent research. AN - 80584725; 1674883 AB - The authors review recent research findings on the drug treatment of schizophrenia. A number of studies emphasize that neuroleptic medications are severely limited by neurological side effects that include acute extrapyramidal syndromes and tardive dyskinesia. Studies comparing neuroleptic doses in both acute and maintenance therapy have encouraged clinicians to evaluate methods for treating patients with the lowest effective dose. Other studies, but not all, indicate that plasma level measurement may be helpful in decision making about drug dosage. The management of schizophrenic patients with illnesses that are refractory to conventional neuroleptics is also discussed. Clozapine, an atypical neuroleptic, may be more effective than other available neuroleptics for severely ill, treatment refractory patients or patients who are unable to tolerate the neurological side effects of typical neuroleptics. JF - Schizophrenia research AU - Marder, S R AU - Wirshing, W C AU - Van Putten, T AD - West Los Angeles Veterans Administration Medical Center, Brentwood Division, CA 90073. PY - 1991 SP - 81 EP - 90 VL - 4 IS - 2 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Psychotropic Drugs KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Arousal -- drug effects KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Long-Term Care KW - Antipsychotic Agents -- adverse effects KW - Psychotropic Drugs -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Psychotropic Drugs -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80584725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Drug+treatment+of+schizophrenia.+Overview+of+recent+research.&rft.au=Marder%2C+S+R%3BWirshing%2C+W+C%3BVan+Putten%2C+T&rft.aulast=Marder&rft.aufirst=S&rft.date=1991-03-01&rft.volume=4&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-11 N1 - Date created - 1991-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of suture and tubulization nerve repair techniques in a primate. AN - 80536503; 1850770 AB - This study compared standard methods of nerve repair, epineurial or perineurial sutures with a technique termed fascicular tubulization using a biodegradable polyglycolic acid tube in a nonhuman primate model. Electrophysiologic analysis demonstrated that the percentage of proximal axons that conducted across the repair site did not significantly differ among the three techniques while epineurial suture repairs were associated with significantly longer conduction delays across the repair site compared with the other two techniques. Even though fascicular tubulization using the current polyglycolic acid tube resulted in regeneration equal to the currently perceived best suture repair technique, associated technical problems with the current tube design indicate that this fascicular tubulization technique cannot, at present, be considered as an alternative to present clinically used nerve suture techniques. JF - The Journal of hand surgery AU - Hentz, V R AU - Rosen, J M AU - Xiao, S J AU - McGill, K C AU - Abraham, G AD - Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, Calif. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 251 EP - 261 VL - 16 IS - 2 SN - 0363-5023, 0363-5023 KW - Polyglycolic Acid KW - 26009-03-0 KW - Index Medicus KW - Neural Conduction -- physiology KW - Animals KW - Nerve Crush KW - Macaca fascicularis KW - Nerve Regeneration -- physiology KW - Biodegradation, Environmental KW - Axons -- physiology KW - Ulnar Nerve -- physiology KW - Ulnar Nerve -- surgery KW - Median Nerve -- physiology KW - Suture Techniques KW - Median Nerve -- surgery KW - Prostheses and Implants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80536503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+hand+surgery&rft.atitle=A+comparison+of+suture+and+tubulization+nerve+repair+techniques+in+a+primate.&rft.au=Hentz%2C+V+R%3BRosen%2C+J+M%3BXiao%2C+S+J%3BMcGill%2C+K+C%3BAbraham%2C+G&rft.aulast=Hentz&rft.aufirst=V&rft.date=1991-03-01&rft.volume=16&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+hand+surgery&rft.issn=03635023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Decrease in endothelial cell-dependent protein C activation induced by thrombomodulin by treatment with cyclosporine. AN - 80482157; 1848730 AB - The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr with a wide range of CSA concentrations. After removal of CSA and incubation with thrombin and purified protein C, thrombomodulin-dependent protein C activation was measured with an S-2238-based kinetic chromogenic assay. As compared to control, a significant fall in thrombomodulin activity occurred after 24-hr incubation with 100 (70.8 +/- 15.8%, P less than 0.05), 1000 (64.9 +/- 16.6%, P less than 0.05), or 10,000 (28.9 +/- 12.3%, P less than 0.05) ng/ml of CSA. A comparable inhibition of thrombomodulin activity was also observed in cultured renal artery endothelial cells (67.5 +/- 12.6%, P less than 0.05), after 24-hr incubation with 5000 ng/ml CSA. In cells incubated with 5000 ng/ml of CSA for 4 hr, thrombomodulin activity fell by almost 15% (85.6 +/- 8.3%, P less than 0.05) and tended to plateau between 7 hr (73.8 +/- 12.7%, P less than 0.05), and 24 hr of incubation (72.7 +/- 8.9%, P less than 0.05). These results indicate that CSA produces a time- and dose-dependent reduction in thrombomodulin activity of cultured endothelial cells, downregulating the protein C anticoagulant pathway, thereby increasing the risk of thrombosis. JF - Transplantation AU - Garcia-Maldonado, M AU - Kaufman, C E AU - Comp, P C AD - Department of Medicine, University of Oklahoma, Oklahoma City Veterans Administration Medical Center, Oklahoma City 73104. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 701 EP - 705 VL - 51 IS - 3 SN - 0041-1337, 0041-1337 KW - Cyclosporins KW - 0 KW - Protein C KW - Receptors, Cell Surface KW - Receptors, Thrombin KW - Thrombin KW - EC 3.4.21.5 KW - Index Medicus KW - Thrombosis -- chemically induced KW - Thrombin -- physiology KW - Models, Cardiovascular KW - Animals KW - Cattle KW - Cells, Cultured KW - Kinetics KW - Aorta KW - Renal Artery KW - Protein C -- metabolism KW - Endothelium, Vascular -- drug effects KW - Cyclosporins -- toxicity KW - Cyclosporins -- pharmacology KW - Receptors, Cell Surface -- physiology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80482157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Decrease+in+endothelial+cell-dependent+protein+C+activation+induced+by+thrombomodulin+by+treatment+with+cyclosporine.&rft.au=Garcia-Maldonado%2C+M%3BKaufman%2C+C+E%3BComp%2C+P+C&rft.aulast=Garcia-Maldonado&rft.aufirst=M&rft.date=1991-03-01&rft.volume=51&rft.issue=3&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of alcohols and other hypnotics in mice selected for differential sensitivity to hypothermic actions of ethanol. AN - 80480341; 2005589 AB - Mice selectively bred for resistance (HOT) and sensitivity (COLD) to the hypothermic effect of an acute dose of ethanol were tested twice during the course of genetic selection for their hypothermic response to other alcohols and sedative hypnotics. The drugs administered were ethanol, propanol, n-butanol, t-butanol, pentanol, diazepam, phenobarbital, pentobarbital, methyprylon and ethchlorvynol, all of which have sedative effects on the central nervous system, and hydralazine, a peripheral vasodilator. All drugs decreased body temperature of both HOT and COLD mice. In mice selected for seven to nine generations, COLD mice were more sensitive than HOT mice to all sedative drugs. The longer-chain alcohols were more potent than ethanol in inducing hypothermia, but the magnitude of the response difference between HOT and COLD mice appeared to be smaller. The difference between HOT and COLD mice in hypothermic sensitivity to an acute dose of ethanol was greater after 11-15 generations of selection than after seven generations. Similarly, the differential effect of the other alcohols, phenobarbital, pentobarbital, and methyprylon, on HOT and COLD mice increased with more generations of selection but to a lesser extent than ethanol. These data demonstrate that selecting for sensitivity to acute ethanol hypothermia has produced mice that are also differentially sensitive to other sedative hypnotic agents. They also support the hypothesis that the drugs used in the present study share a common mechanism of action for inducing hypothermia, which may be regulated by a common set of genes.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Feller, D J AU - Crabbe, J C AD - Research Service, Veterans Administration Medical Center, Portland, Oregon. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 947 EP - 953 VL - 256 IS - 3 SN - 0022-3565, 0022-3565 KW - Alcohols KW - 0 KW - Hypnotics and Sedatives KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Body Temperature -- drug effects KW - Mice KW - Male KW - Female KW - Structure-Activity Relationship KW - Hypnotics and Sedatives -- toxicity KW - Hypothermia -- chemically induced KW - Ethanol -- toxicity KW - Alcohols -- toxicity KW - Hypothermia -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80480341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effect+of+alcohols+and+other+hypnotics+in+mice+selected+for+differential+sensitivity+to+hypothermic+actions+of+ethanol.&rft.au=Feller%2C+D+J%3BCrabbe%2C+J+C&rft.aulast=Feller&rft.aufirst=D&rft.date=1991-03-01&rft.volume=256&rft.issue=3&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice. AN - 80478777; 2005587 AB - Differences in antinociceptive (inhibition of tail-flick response) action of morphine and Tyr-D-Ala2-Gly-NMePhe4-ol5 (DAMGO) were demonstrated by intracerebroventricular (i.c.v.) administration of these agonists along with intrathecal (i.t.) administration of a variety of antagonists: yohimbine, methysergide, naloxone and nor-binaltorphimine. Intracerebroventricular morphine analgesia was antagonized by either i.t. yohimbine or methysergide, whereas i.c.v. DAMGO analgesia was only antagonized by i.t. methysergide. Thus, for i.c.v. morphine-induced analgesia, descending spinal noradrenergic and serotonergic systems were involved, whereas for DAMGO analgesia, only the serotonergic system was involved. The dose-response curve for i.c.v. morphine reached a plateau at high doses, whereas i.c.v. DAMGO analgesia peaked at 10 ng and then decreased thereafter, producing a bell-shaped dose-response curve. This decrement in analgesic response could be reversed by low doses of i.t. methysergide and i.t. pindolol. It was concluded that activation of serotonin-1 (5-HT1) receptors plays a role in the decrease in analgesia from high doses of DAMGO. Combinations of i.t. morphine with i.t. 5-HT or i.t. clonidine produced additive or greater analgesic responses. Combinations of i.t. DAMGO with i.t. 5-HT or i.t. clonidine produced less than additive interactions. Part of the latter responses appeared to be due to activation of 5-HT1 receptors; blockade of these receptors by pindolol enhanced i.t. DAMGO-induced analgesia. Morphine and DAMGO differ further because i.c.v. morphine activated a descending antianalgesic pathway mediated by spinal dynorphin A(1-17), whereas i.c.v. DAMGO at a high dose did not. Thus, morphine and DAMGO differ in their modes of antinociceptive action as measured by the tail-flick response. JF - The Journal of pharmacology and experimental therapeutics AU - Arts, K S AU - Holmes, B B AU - Fujimoto, J M AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 890 EP - 896 VL - 256 IS - 3 SN - 0022-3565, 0022-3565 KW - Enkephalins KW - 0 KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - Yohimbine KW - 2Y49VWD90Q KW - Serotonin KW - 333DO1RDJY KW - Morphine KW - 76I7G6D29C KW - Clonidine KW - MN3L5RMN02 KW - Methysergide KW - XZA9HY6Z98 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Drug Interactions KW - Yohimbine -- pharmacology KW - Dose-Response Relationship, Drug KW - Injections, Spinal KW - Methysergide -- pharmacology KW - Mice KW - Clonidine -- pharmacology KW - Male KW - Injections, Intraventricular KW - Serotonin -- pharmacology KW - Enkephalins -- pharmacology KW - Analgesia KW - Enkephalins -- administration & dosage KW - Morphine -- administration & dosage KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80478777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Differential+contribution+of+descending+serotonergic+and+noradrenergic+systems+to+central+Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5+%28DAMGO%29+and+morphine-induced+antinociception+in+mice.&rft.au=Arts%2C+K+S%3BHolmes%2C+B+B%3BFujimoto%2C+J+M&rft.aulast=Arts&rft.aufirst=K&rft.date=1991-03-01&rft.volume=256&rft.issue=3&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-24 N1 - Date created - 1991-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of blood flow and alkaline secretion in acid-induced deep duodenal villous injury in rats. AN - 80472679; 2003607 AB - The effect of 16,16-dimethylprostaglandin E2 (dmPGE2) and corticotropin-releasing factor (CRF) on duodenal blood flow, alkaline secretion, and acid-induced deep duodenal villous injury was studied. The duodena of anesthetized rats were prepared for simultaneous measurement of alkaline secretion by back titration, and blood flow by hydrogen gas clearance; or for perfusion with 0.1 N HCl and histological examination of villous injury. The results revealed that the dmPGE2-induced increase in basal alkaline secretion (due solely to an increase in the volume of secretion) appears to be a better predictor of protection against exogenous acid-induced deep duodenal villous injury than rise in duodenal blood flow, since CRF induces a similar rise in duodenal blood flow but does not enhance alkaline secretion or reduce acid-induced villous damage. The absence of a greater loss of H+ during acid perfusion of the duodenum in the dmPGE2-treated rats, however, suggests that the mechanism of the dmPGE2 protection against acid-induced deep duodenal villous injury cannot be explained entirely by its ability to increase basal duodenal alkaline secretion. JF - The American journal of physiology AU - Leung, F W AD - Research Service, Veterans Administration Medical Center, Sepulveda 91343. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - G399 EP - G404 VL - 260 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - 16,16-Dimethylprostaglandin E2 KW - M790V82VAC KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Regional Blood Flow -- drug effects KW - Male KW - Hydrochloric Acid -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - 16,16-Dimethylprostaglandin E2 -- pharmacology KW - Intestinal Mucosa -- blood supply KW - Duodenum -- blood supply KW - Corticotropin-Releasing Hormone -- pharmacology KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80472679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+blood+flow+and+alkaline+secretion+in+acid-induced+deep+duodenal+villous+injury+in+rats.&rft.au=Leung%2C+F+W&rft.aulast=Leung&rft.aufirst=F&rft.date=1991-03-01&rft.volume=260&rft.issue=3+Pt+1&rft.spage=G399&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-12 N1 - Date created - 1991-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dual pathways for agonist-stimulated arachidonic acid release in pancreatic acini: roles in secretion. AN - 80472636; 1706148 AB - The present experiments were performed to determine pathways responsible for arachidonic acid release stimulated by cholecystokinin (CCK) and phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA), and the roles of pathways in the secretory response in dispersed acini from guinea pig pancreas. Both CCK-octapeptide (CCK-OP) and PMA increased intracellular arachidonic acid. To determine the source of released arachidonic acid, we measured the effects of PMA and CCK-OP on cellular 1,2-diacylglycerol and lysophosphatidylcholine (LPC) and of diglyceride lipase inhibitor RHC 80267 on [3H]arachidonic acid release. Both PMA and CCK-OP increased 1,2-diacylglycerol and LPC. RHC 80267 had no effect on LPC but inhibited the increase in [3H]arachidonic acid release with a concentration of CCK-OP that was maximal for enzyme secretion. The increase in [3H]arachidonic acid release with PMA or a supramaximal concentration of CCK-OP was not inhibited by RHC 80267. In parallel fashion, RHC 80267 inhibited amylase release caused by maximally effective concentrations of CCK-OP but not that caused by PMA or by supramaximally effective concentrations of CCK-OP. Arachidonic acid stimulated amylase release. Exogenous addition of phospholipase A2 caused increases in [3H]arachidonic acid release, LPC formation, and amylase release. The results indicate that there are at least two pathways responsible for the increase in free cellular arachidonic acid stimulated by pancreatic agonists. One is sequential action of phospholipase C and diglyceride lipase on phosphatidylinositol. The other is a phospholipase A action on phosphatidylcholine. The results also suggest a stimulatory role for both pathways in the secretory response. JF - The American journal of physiology AU - Pandol, S J AU - Hsu, Y L AU - Kondratenko, N F AU - Schoeffield-Payne, M S AU - Steinbach, J H AD - Department of Medicine, Veterans Administration Medical Center, San Diego, California. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - G423 EP - G433 VL - 260 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Arachidonic Acids KW - 0 KW - Cyclohexanones KW - Diglycerides KW - Fatty Acids KW - Lysophosphatidylcholines KW - Phosphatidylcholines KW - 1,6-bis(cyclohexyloximinocarbonyl)hexane KW - 83654-05-1 KW - Phospholipases A KW - EC 3.1.1.32 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Amylases KW - EC 3.2.1.- KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Lysophosphatidylcholines -- isolation & purification KW - Guinea Pigs KW - Cyclohexanones -- pharmacology KW - Phosphatidylcholines -- metabolism KW - Phosphatidylcholines -- isolation & purification KW - Lipoprotein Lipase -- antagonists & inhibitors KW - Phospholipases A -- pharmacology KW - Kinetics KW - In Vitro Techniques KW - Lysophosphatidylcholines -- pharmacology KW - Lysophosphatidylcholines -- metabolism KW - Fatty Acids -- analysis KW - Diglycerides -- metabolism KW - Pancreas -- cytology KW - Pancreas -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Arachidonic Acids -- metabolism KW - Amylases -- secretion KW - Pancreas -- drug effects KW - Sincalide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80472636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Dual+pathways+for+agonist-stimulated+arachidonic+acid+release+in+pancreatic+acini%3A+roles+in+secretion.&rft.au=Pandol%2C+S+J%3BHsu%2C+Y+L%3BKondratenko%2C+N+F%3BSchoeffield-Payne%2C+M+S%3BSteinbach%2C+J+H&rft.aulast=Pandol&rft.aufirst=S&rft.date=1991-03-01&rft.volume=260&rft.issue=3+Pt+1&rft.spage=G423&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-12 N1 - Date created - 1991-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic effect of human lysozyme plus ampicillin or beta-lysin on the killing of Listeria monocytogenes. AN - 80451742; 1899873 AB - Although ampicillin is often only bacteriostatic for Listeria monocytogenes in vitro, serum from ampicillin-treated patients was bactericidal. The bactericidal effect of serum was partly removed by bentonite, Seitz-filtration, and addition of FeCl3, suggesting it is mediated by lysozyme and beta-lysin. Partly purified human beta-lysin plus purified human lysozyme or either protein plus ampicillin were bactericidal for L. monocytogenes. Hen egg white lysozyme was not active. Lysozyme and beta-lysin were not synergistic with tetracycline, trimethoprim/sulfamethoxazole, or chloramphenicol. Thus, lysozyme and beta-lysin may play a role in the natural resistance to L. monocytogenes, and these serum proteins could contribute to the effectiveness of ampicillin in vivo. JF - The Journal of infectious diseases AU - Asensi, V AU - Fierer, J AD - Department of Medicine, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 574 EP - 578 VL - 163 IS - 3 SN - 0022-1899, 0022-1899 KW - Antimicrobial Cationic Peptides KW - 0 KW - Blood Proteins KW - Proteins KW - beta lysin, human KW - Ampicillin KW - 7C782967RD KW - Muramidase KW - EC 3.2.1.17 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Proteins -- pharmacology KW - Listeria monocytogenes -- drug effects KW - Proteins -- isolation & purification KW - Muramidase -- pharmacology KW - Ampicillin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80451742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Synergistic+effect+of+human+lysozyme+plus+ampicillin+or+beta-lysin+on+the+killing+of+Listeria+monocytogenes.&rft.au=Asensi%2C+V%3BFierer%2C+J&rft.aulast=Asensi&rft.aufirst=V&rft.date=1991-03-01&rft.volume=163&rft.issue=3&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-25 N1 - Date created - 1991-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholism and associated malnutrition in the elderly. AN - 72693623; 1802200 AB - Although most free-living people over age 55 yr use alcohol occasionally, both the fraction of people drinking and the magnitude of individual alcohol consumption decrease with every decade of age. Overall, approximately 5% of drinkers over age 55 yr use alcohol at excessive levels, i.e., sufficient to interfere with health or social functioning. As age increases, the fraction of drinkers with alcohol-caused central nervous system disease and cirrhosis increases, indicating increased sensitivity to alcohol injury. Beyond age 70 yr, new-onset alcoholism is more common than long-standing alcoholism. Malnutrition in the elderly alcoholic person is rare; it usually is caused by multiple factors, including alcohol displacing nutrient-rich diet factors, disease, limited availability of food, or altered metabolism increasing nutrient requirement. The recognition of alcohol and malnutrition problems in the elderly is more difficult than in younger people. JF - Nutrition (Burbank, Los Angeles County, Calif.) AU - Klein, S AU - Iber, F L AD - Department of Nutrition, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois 60141. PY - 1991 SP - 75 EP - 79 VL - 7 IS - 2 SN - 0899-9007, 0899-9007 KW - Index Medicus KW - Nutritional Status KW - Humans KW - Aged KW - Middle Aged KW - Aging -- physiology KW - Alcoholism -- epidemiology KW - Nutrition Disorders -- etiology KW - Alcoholism -- complications KW - Nutrition Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72693623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.atitle=Alcoholism+and+associated+malnutrition+in+the+elderly.&rft.au=Klein%2C+S%3BIber%2C+F+L&rft.aulast=Klein&rft.aufirst=S&rft.date=1991-03-01&rft.volume=7&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.issn=08999007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-30 N1 - Date created - 1992-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The catalytic effect of bovine serum albumin on the ortho rearrangement of the potential ultimate carcinogen, N-(sulfooxy)-2-(acetylamino)fluorene, generated enzymatically from N-hydroxy-2-(acetylamino)fluorene and evidence for substrate specificity of the enzymatic sulfonation of arylhydroxamic acids. AN - 72632428; 1782347 AB - This investigation examines the catalytic effect of bovine serum albumin on the ortho rearrangement of the possible ultimate carcinogen, N-(sulfooxy)-2-(acetylamino)fluorene, generated from N-hydroxy-2-(acetylamino)fluorene by the sulfotransferase(s) in the cytosol of rat liver. With various preparations of cytosol, 55-75% of the substrate, N-hydroxy-2-(acetylamino)-fluorene, was found to rearrange to the nonmutagenic and noncarcinogenic o-(sulfooxy) esters, 1- and 3-(sulfooxy)-2-(acetylamino)fluorene, in the presence of bovine serum albumin, while less than 1% of the substrate rearranged in its absence. In presence of bovine serum albumin the cytosolic reduction of N-(sulfooxy)-2-(acetylamino)fluorene to 2-(acetylamino)fluorene decreased by 60-90% and its solvolytic degradation to 4-hydroxy-2-(acetylamino)fluorene by 80-90%. The covalent interaction of enzymatically generated N-(sulfooxy)-2-(acetylamino)fluorene with the nucleophilic acceptors, N-acetyl-L-methionine and guanosine, was lowered by greater than 90% by addition of bovine serum albumin. These measurements indicated that the albumin-catalyzed ortho rearrangement controls the rates of concurrent metabolic and degradative reactions of N-(sulfooxy)-2-(acetylamino)fluorene. The results are in agreement with previous findings of a catalytic effect of serum albumin on the ortho rearrangement of synthetic N-(sulfooxy)-2-(acetylamino)fluorene. In contrast to its catalytic effect on the formation of o-(sulfooxy) esters from N-(sulfooxy)-2-(acetylamino)fluorene, bovine serum albumin had no effect on the formation of o-(acetylamino)fluorenols. To assess the substrate specificity of bovine serum albumin, its effect on the rearrangement of N-hydroxy-2-(benzoylamino)fluorene, a carcinogenic analogue of N-hydroxy-2-(acetylamino)fluorene, was analyzed under conditions of cytosolic sulfonation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Kolanczyk, R C AU - Rutks, I R AU - Gutmann, H R AD - Research Service, Veterans' Administration Medical Center, Minneapolis, Minnesota 55417. PY - 1991 SP - 187 EP - 194 VL - 4 IS - 2 SN - 0893-228X, 0893-228X KW - Carcinogens KW - 0 KW - Fluorenes KW - Hydroxamic Acids KW - Serum Albumin, Bovine KW - N-1-sulfooxy-2-benzoylaminofluorene KW - 131657-39-1 KW - 2-acetylaminofluorene-N-sulfate KW - 16808-85-8 KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Fluorenes -- isolation & purification KW - Fluorenes -- chemical synthesis KW - Animals KW - Liver -- enzymology KW - Liver -- metabolism KW - Substrate Specificity KW - Hydroxamic Acids -- metabolism KW - Male KW - Hydroxyacetylaminofluorene -- metabolism KW - 2-Acetylaminofluorene -- chemical synthesis KW - Carcinogens -- metabolism KW - 2-Acetylaminofluorene -- metabolism KW - Serum Albumin, Bovine -- pharmacology KW - 2-Acetylaminofluorene -- analogs & derivatives KW - Carcinogens -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72632428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=The+catalytic+effect+of+bovine+serum+albumin+on+the+ortho+rearrangement+of+the+potential+ultimate+carcinogen%2C+N-%28sulfooxy%29-2-%28acetylamino%29fluorene%2C+generated+enzymatically+from+N-hydroxy-2-%28acetylamino%29fluorene+and+evidence+for+substrate+specificity+of+the+enzymatic+sulfonation+of+arylhydroxamic+acids.&rft.au=Kolanczyk%2C+R+C%3BRutks%2C+I+R%3BGutmann%2C+H+R&rft.aulast=Kolanczyk&rft.aufirst=R&rft.date=1991-03-01&rft.volume=4&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-13 N1 - Date created - 1992-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Reliability of Peer Review for Manuscript and Grant Submissions: A Cross-Disciplinary Investigation AN - 61299733; 92Y6513 AB - A critical examination of the peer-review process used in the evaluation of manuscript submissions & grant applications. Research designs & statistical procedures are reviewed in major studies of peer review across disciplines. It is contended that referees of grant proposals agree much more about what is unworthy of support than about what has scientific value. In the case of manuscript submissions, this is argued to depend on whether a discipline or subfield is general & diffuse vs specific & focused: in the former, there is much more agreement on rejection than acceptance, but in the latter, the opposite is true. Several suggestions are made for improving the reliability & quality of peer review, & for future research, argued to be especially needed in the physical sciences. Open Peer Commentary contains contributions from Kenneth M. Adams; J. Scott Armstrong & Raymond Hubbard; John C. Bailar; Robert F. Bornstein; Patricia Cohen; Stephen Cole; Andrew M. Coleman; John D. Cone; Rick Crandall; Fred Delcomyn; Marilyn E. Demorest; Douglas Lee Eckberg; Jack M. Fletcher; Steve Fuller; J. Barnard Gilmore; Michael E. Gorman; Richard Greene; Lowell L. Hargens; Charles A. Kiesler; Helena Chmura Kraemer; Donald Laming; Stephen P. Lock; Michael J. Mahoney; Herbert W. Marsh & Samuel Ball; Linda D. Nelson; Henry L. Roediger, III; Robert Rosenthal; Byron P. Rourke; Kurt Salzinger; Peter H. Schonemann; Lawrence J. Stricker; Peter T. Tyrer; Gerald S. Wasserman; & Thomas R. Zentall. In Reflections from the Peer Review Mirror, Cicchetti responds in turn to each of five areas of concern offered by his commentators: (1) methodological, statistical, & analytic strategies; (2) interpretation of the results; (3) using peer review to improve editorial/funding decisions; (4) improving the peer review process; & (5) future research in peer review. 14 Tables, 4 Figures, 253 References. Adapted from the source document. JF - The Behavioral and Brain Sciences AU - Cicchetti, Domenic V AD - Veterans Administration Medical Center, West Haven CT 06516 Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 119 EP - 135 VL - 14 IS - 1 SN - 0140-525X, 0140-525X KW - peer review's reliability/validity, manuscript/grant submissions KW - article, comments, response KW - Writing for Publication KW - Reliability KW - Grants KW - Validity KW - Peer Review KW - article KW - 1734: sociology of science; sociology of science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61299733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Behavioral+and+Brain+Sciences&rft.atitle=The+Reliability+of+Peer+Review+for+Manuscript+and+Grant+Submissions%3A+A+Cross-Disciplinary+Investigation&rft.au=Cicchetti%2C+Domenic+V&rft.aulast=Cicchetti&rft.aufirst=Domenic&rft.date=1991-03-01&rft.volume=14&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=The+Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - SuppNotes - Comments, 135-167, Response, 167-186. N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Peer Review; Reliability; Validity; Grants; Writing for Publication ER - TY - JOUR T1 - Education and Certification of Mental Health Administrators: The Role of Professional Associations AN - 61270695; 92Y6101 AB - Professional organizations play a role in the education of mental health administrators: eg, some professional associations have certification examinations for administrative psychiatry, while others sponsor meetings aimed at enhancing the skills of their membership; also, requisites for competency of health administrators is embodied in membership requirements. However, consistency & coordination among the professional organizations regarding education & credentialing are lacking. 9 References. Adapted from the source document. JF - Administration and Policy in Mental Health AU - Barton, Gail M AD - Psychiatry Service Veterans Administration Medical Center, White River Junction VT 05001 Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 279 EP - 283 VL - 18 IS - 4 SN - 0894-587X, 0894-587X KW - mental health administrators, education/certification, professional associations' role KW - Professional Associations KW - Administrators KW - Professional Training KW - Higher Education KW - Mental Health KW - Certification KW - Mental Health Services KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61270695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health&rft.atitle=Education+and+Certification+of+Mental+Health+Administrators%3A+The+Role+of+Professional+Associations&rft.au=Barton%2C+Gail+M&rft.aulast=Barton&rft.aufirst=Gail&rft.date=1991-03-01&rft.volume=18&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health&rft.issn=0894587X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental Health; Mental Health Services; Administrators; Professional Associations; Professional Training; Certification; Higher Education ER - TY - JOUR T1 - Social Support and Outcome of Alcoholism Treatment: An Exploratory Analysis AN - 1761712267; 199200247 AB - To examine the effect of social support on posthospitalization outcomes among alcoholics, data were obtained from a sample of 61 male consecutive admissions to a midwestern veterans hospital alcoholism treatment unit. During the 21-day treatment program, Ss responded to a scale measuring 6 forms of social support: guidance, reliable alliance, reassurance of worth, opportunity for nurturance, attachment, & social integration. Results show that social support -- particularly reassurance of worth -- & previous hospitalizations were significant predictors of length of time to readmission: higher levels of reassurance led to longer periods of sobriety, while higher numbers of previous hospitalizations had the reverse relationship. These findings suggest that social support is of significant importance to the recovering alcoholic, & that its effect on treatment outcome is independent of a record of previous treatment failures. Implications for alcoholism treatment programs are discussed, & recommendations made for additional studies using a larger sample. 4 Tables, 1 Figure, 27 References. S. Dilts JF - The American Journal of Drug and Alcohol Abuse AU - Booth, Brenda M AU - Russell, Daniel W AU - Soucek, Susan AU - Laughlin, Philip R AD - Iowa Health Services Research & Development Field Program Veterans Administration Medical Center, Iowa City 52246 Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 87 EP - 101 VL - 18 IS - 1 SN - 0095-2990, 0095-2990 KW - alcoholism, posttreatment outcomes KW - social support KW - scale data KW - males, midwestern veterans' hospital KW - Treatment Outcomes KW - Males KW - Alcoholism KW - Social Support KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761712267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Social+Support+and+Outcome+of+Alcoholism+Treatment%3A+An+Exploratory+Analysis&rft.au=Booth%2C+Brenda+M%3BRussell%2C+Daniel+W%3BSoucek%2C+Susan%3BLaughlin%2C+Philip+R&rft.aulast=Booth&rft.aufirst=Brenda&rft.date=1991-03-01&rft.volume=18&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Outcomes; Alcoholism; Males; Social Support ER - TY - JOUR T1 - Exposure to heat restores sleep in cats with preoptic/anterior hypothalamic cell loss. AN - 80565047; 2029614 AB - Evidence suggests that thermosensitive neurons of the preoptic/anterior hypothalamus (POAH) influence sleep- and arousal-regulating mechanisms. We examined the effects of POAH cell loss, produced by microinjection of neurotoxin (N-methyl-DL-aspartic acid), on sleep and thermoregulation in cats. Cats with bilateral POAH cell loss did not defend their body temperatures in the heat as effectively as normals, and did not initiate panting until brain temperatures rose to abnormally high levels. During 14 h polygraphic recordings of sleep-waking state conducted at an ambient temperature (Ta) of 23 degrees C, POAH-damaged cats exhibited reduced sleep. Amounts of deep slow-wave sleep (SWS2) were significantly less than prelesion values through 7 weeks postlesion; significant REM sleep deficits persisted for 5 weeks. However, these sleep disturbances were dramatically attenuated when cats were exposed to high Tas. During 6 h recordings at Tas of 13, 23, or 33 degrees C, total sleep time was greatest at 33 degrees C at both 2 and 4 weeks postlesion. At 4 weeks, amounts of SWS2 at 33 degrees C were similar to maximal prelesion values. Increased sleep at 33 degrees C was associated with elevated brain temperatures. The finding that, after POAH damage, abnormally high brain temperatures were required to elicit both panting and normal amounts of SWS suggests that impaired hypothalamic sensitivity to heat was responsible for both deficits. These results support the hypothesis that thermosensitive neurons participate in the tonic regulation of sleep and arousal. JF - Brain research AU - Szymusiak, R AU - Danowski, J AU - McGinty, D AD - Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1991/02/08/ PY - 1991 DA - 1991 Feb 08 SP - 134 EP - 138 VL - 541 IS - 1 SN - 0006-8993, 0006-8993 KW - Index Medicus KW - Sleep Stages -- physiology KW - Animals KW - Body Temperature Regulation -- physiology KW - Cats KW - Neurons -- physiology KW - Male KW - Female KW - Cell Survival KW - Sleep -- physiology KW - Preoptic Area -- cytology KW - Hot Temperature KW - Anterior Hypothalamic Nucleus -- physiology KW - Preoptic Area -- physiology KW - Anterior Hypothalamic Nucleus -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80565047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Exposure+to+heat+restores+sleep+in+cats+with+preoptic%2Fanterior+hypothalamic+cell+loss.&rft.au=Szymusiak%2C+R%3BDanowski%2C+J%3BMcGinty%2C+D&rft.aulast=Szymusiak&rft.aufirst=R&rft.date=1991-02-08&rft.volume=541&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-19 N1 - Date created - 1991-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Scar revision. AN - 85227676; pmid-1991064 AB - Different scar revision techniques are compared on similar scars, all on the same patient. Comparison of the final results is unique and interesting and provides insight into choosing the "optimal" technique for these procedures. Historical perspective is provided. JF - Archives of Otolaryngology--Head and Neck Surgery AU - Wolfe, D AU - Davidson, T M AD - Department of Head and Neck Surgery, Veterans Administration Medical Center, San Diego, Calif. PY - 1991 SP - 200 EP - 204 VL - 117 IS - 2 SN - 0886-4470, 0886-4470 KW - Skin KW - Humans KW - Adult KW - Surgery, Plastic KW - Female KW - Forearm KW - Cicatrix UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85227676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Scar+revision.&rft.au=Wolfe%2C+D%3BDavidson%2C+T+M&rft.aulast=Wolfe&rft.aufirst=D&rft.date=1991-02-01&rft.volume=117&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.issn=08864470&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Nonpropulsive esophageal contractions and gastroesophageal reflux. AN - 85227196; pmid-1992626 AB - Nonpropulsive esophageal contractions radiologically described as tertiary contractions or "corkscrew" esophagus suggest the presence of an underlying motility disorder and may lead to impaired acid clearance. The goals of this study were to determine the prevalence and role of gastroesophageal reflux (GER) in patients with tertiary contractions. Thirty-five consecutive patients with spontaneous, repetitive, nonpropulsive esophageal contractions noted on esophagography were studied with endoscopy, infusion esophageal manometry, and 24-h ambulatory pH monitoring. All patients had esophageal symptoms, mainly dysphagia, heartburn, and chest pain, but only three were found to have esophagitis by endoscopy and biopsy. Nineteen patients had repetitive, nonlumen-obliterating, nonperistaltic (tertiary) contractions, six had corkscrew esophagus, and 10 had forceful, lumen-obliterating simultaneous contractions (rosary bead esophagus). Twenty patients (58%) had GER by pH criteria with mean values: % time pH less than 4, 40.9; %upright pH less than 4, 41; %supine pH less than 4, 44.3%; number of episodes with greater than 5 min of pH less than 4, 12. Esophageal motility revealed "nutcracker" esophagus in eight, low LESP in two, and nonspecific esophageal motility disorder in 10. Symptoms or severity of nonperistaltic contractions did not correlate with GER. Radiologically demonstrable free reflux or the presence of heartburn did not predict GER. We conclude that 1) GER occurs in up to 58% of patients with nonpropulsive (tertiary) esophageal contractions on esophagography, and may play a role in the induction of abnormal peristaltic activity of the esophageal body; 2) GER is usually not associated with endoscopic evidence of esophagitis or characteristic symptoms, and is recognized by 24-h pH monitoring. We speculate that detection and treatment of GER may improve the symptomatic management of patients with nonpropulsive esophageal contractions. JF - The American Journal of Gastroenterology AU - Triadafilopoulos, G AU - Castillo, T AD - Gastroenterology Section, Veterans Administration Medical Center, Martinez, California. PY - 1991 SP - 153 EP - 159 VL - 86 IS - 2 SN - 0002-9270, 0002-9270 KW - Esophagus KW - Human KW - Hydrogen-Ion Concentration KW - Aged KW - Biopsy KW - Monitoring, Physiologic KW - Esophagoscopy KW - Gastroesophageal Reflux KW - Aged, 80 and over KW - Adult KW - Middle Age KW - Manometry KW - Male KW - Female KW - Prevalence KW - Gastrointestinal Motility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85227196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Nonpropulsive+esophageal+contractions+and+gastroesophageal+reflux.&rft.au=Triadafilopoulos%2C+G%3BCastillo%2C+T&rft.aulast=Triadafilopoulos&rft.aufirst=G&rft.date=1991-02-01&rft.volume=86&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Symptoms of anxiety in inpatient alcoholics with and without DSM-III-R anxiety diagnoses. AN - 80542573; 2024720 AB - Self- and observer-rating scales were administered to alcohol-dependent inpatients during acute withdrawal and regularly for 3 weeks. Following a structured diagnostic interview (SCID) at the end of the 3rd week of hospitalization, subjects were divided into two groups: a dual-diagnosed group (alcohol dependence and anxiety disorder) and an alcohol-only group (no other current Axis I diagnosis). The results demonstrated that the dual-diagnosed subjects experienced higher anxiety levels during and after acute alcohol withdrawal. All rating scales (i.e., Sheehan Patient Rated Anxiety Scale, Spielberger State Anxiety Inventory, Zung Rating Scale for Anxiety, and Hamilton Rating Scale for Anxiety) were analyzed to obtain the best combination of sensitivity and specificity. Taken together, the results indicate that it may be possible to identify alcoholics who require additional psychiatric evaluation early in treatment. This would allow a treatment plan which could be used to address both psychiatric and substance abuse problems. JF - Alcoholism, clinical and experimental research AU - Thevos, A K AU - Johnston, A L AU - Latham, P K AU - Randall, C L AU - Adinoff, B AU - Malcolm, R AD - Veterans Administration Medical Center, Charleston, South Carolina 29403. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 102 EP - 105 VL - 15 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Agoraphobia -- diagnosis KW - Agoraphobia -- psychology KW - Phobic Disorders -- psychology KW - Phobic Disorders -- complications KW - Humans KW - Adult KW - Agoraphobia -- complications KW - Phobic Disorders -- diagnosis KW - Panic KW - Male KW - Psychiatric Status Rating Scales KW - Anxiety Disorders -- psychology KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Anxiety Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80542573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Symptoms+of+anxiety+in+inpatient+alcoholics+with+and+without+DSM-III-R+anxiety+diagnoses.&rft.au=Thevos%2C+A+K%3BJohnston%2C+A+L%3BLatham%2C+P+K%3BRandall%2C+C+L%3BAdinoff%2C+B%3BMalcolm%2C+R&rft.aulast=Thevos&rft.aufirst=A&rft.date=1991-02-01&rft.volume=15&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-04 N1 - Date created - 1991-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In-111 labeled monoclonal anti-carcinoembryonic antigen antibody (ZCE025) in the immunoscintigraphic imaging of metastatic antigen-producing adenocarcinomas. AN - 80474039; 2004491 AB - The carcinoembryonic antigen (CEA) is a clinically useful marker since it is expressed by adenocarcinomas of diverse origin. Detection and quantitation of circulating CEA levels is used to follow the clinical course of metastatic adenocarcinoma. In this phase I study, the toxicity, pharmacokinetics, and optimal imaging dose of an In-111 labeled monoclonal anti-CEA antibody (ZCE025) was studied in patients with colorectal carcinoma or any CEA-producing tumor. Twenty-four of 26 evaluable patients (92%) demonstrated at least one site of tumor-specific antibody uptake. Sixty-seven sites of metastatic cancer were identified by conventional diagnostic studies. Twenty-nine (43%) of these sites were demonstrable by radioimmune imaging using ZCE025. Twenty-five additional sites of antibody uptake were observed but could not be associated with metastatic deposits. Lymph node and visceral metastases were visualized more frequently than bone, subcutaneous, lung, or liver metastases. Neither tumor size nor antibody dose (2.5-40 mg) appeared to influence the frequency of tumor imaging. The pharmacokinetics of the In-111 labeled antibody fitted a two-compartment model, and patients receiving less than 10 mg of antibody showed a faster clearance of the antibody than those who received greater than 10 mg. JF - Clinical nuclear medicine AU - Saleh, M N AU - Wheeler, R H AU - Lee, J Y AU - Khazaeli, M B AU - Unger, M W AU - Russell, C H AU - LoBuglio, A F AD - Department of Medicine, Veterans Administration Hospital, Birmingham, Alabama. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 110 EP - 116 VL - 16 IS - 2 SN - 0363-9762, 0363-9762 KW - Antibodies, Monoclonal KW - 0 KW - Carcinoembryonic Antigen KW - Indium Radioisotopes KW - Index Medicus KW - Tomography, Emission-Computed, Single-Photon KW - Rectal Neoplasms -- immunology KW - Bone Neoplasms -- immunology KW - Rectal Neoplasms -- diagnostic imaging KW - Bone Neoplasms -- diagnostic imaging KW - Humans KW - Liver Neoplasms -- diagnostic imaging KW - Liver Neoplasms -- secondary KW - Colonic Neoplasms -- immunology KW - Colonic Neoplasms -- diagnostic imaging KW - Bone Neoplasms -- secondary KW - Liver Neoplasms -- immunology KW - Adenocarcinoma -- diagnostic imaging KW - Carcinoembryonic Antigen -- immunology KW - Antibodies, Monoclonal -- pharmacokinetics KW - Adenocarcinoma -- secondary KW - Antibodies, Monoclonal -- adverse effects KW - Adenocarcinoma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80474039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=In-111+labeled+monoclonal+anti-carcinoembryonic+antigen+antibody+%28ZCE025%29+in+the+immunoscintigraphic+imaging+of+metastatic+antigen-producing+adenocarcinomas.&rft.au=Saleh%2C+M+N%3BWheeler%2C+R+H%3BLee%2C+J+Y%3BKhazaeli%2C+M+B%3BUnger%2C+M+W%3BRussell%2C+C+H%3BLoBuglio%2C+A+F&rft.aulast=Saleh&rft.aufirst=M&rft.date=1991-02-01&rft.volume=16&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-25 N1 - Date created - 1991-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyproheptadine for combat nightmares in post-traumatic stress disorder and dream anxiety disorder. AN - 80471109; 1900585 AB - Pharmacologic treatment of patients with post-traumatic stress disorder often involves antidepressant drugs. Combat nightmares often persist. The addition of cyproheptadine, in a median dose of 16-24 mg orally at night, controls the nightmares. JF - Military medicine AU - Brophy, M H AD - Psychiatry Service, Veterans Administration Medical Center, Dallas, TX 75216. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 100 EP - 101 VL - 156 IS - 2 SN - 0026-4075, 0026-4075 KW - Antidepressive Agents KW - 0 KW - Cyproheptadine KW - 2YHB6175DO KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Antidepressive Agents -- therapeutic use KW - Aged KW - Male KW - Anxiety Disorders -- drug therapy KW - Cyproheptadine -- administration & dosage KW - Stress Disorders, Post-Traumatic -- complications KW - Sleep Wake Disorders -- drug therapy KW - Military Personnel KW - Sleep Wake Disorders -- etiology KW - Cyproheptadine -- therapeutic use KW - Cyproheptadine -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Anxiety Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80471109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Cyproheptadine+for+combat+nightmares+in+post-traumatic+stress+disorder+and+dream+anxiety+disorder.&rft.au=Brophy%2C+M+H&rft.aulast=Brophy&rft.aufirst=M&rft.date=1991-02-01&rft.volume=156&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-17 N1 - Date created - 1991-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. AN - 80445492; 1995437 AB - Although altered cytokine homeostasis has been implicated in the pathogenesis of alcoholic liver disease, the relationship between cytokines and metabolic consequences of alcoholic liver disease is unknown. We, therefore, sought to correlate circulating concentrations of tumor necrosis factor-alpha, interleukin-1 and interleukin-6 to clinical and biochemical parameters of liver disease in chronic alcoholic patients. We used an enzyme-linked immunosorbent assay to measure plasma tumor necrosis factor and interleukin-1 and a bioassay to measure serum interleukin-6 in three groups of alcoholic men as follows: (a) actively drinking alcoholic men without evidence of chronic liver disease, (b) nondrinking alcoholic men with stable cirrhosis and (c) patients with acute alcoholic hepatitis. Mean cytokine concentrations were elevated in cirrhotic patients and alcoholic hepatitis patients compared with controls and alcoholic patients without liver disease. Tumor necrosis factor-alpha and interleukin-1 alpha concentrations remained elevated for up to 6 mo after diagnosis of alcoholic hepatitis, whereas interleukin-6 normalized in parallel with clinical recovery. Concentrations of all three cytokines were correlated with biochemical parameters of liver injury and hepatic protein synthesis plus serum immunoglobulin concentrations. We could not demonstrate a relationship between cytokine concentrations and peripheral endotoxemia. Percentages of peripheral blood monocytes that reacted with monoclonal antibodies to CD25 (interleukin-2 receptor) and human lymphocyte antigen-DR were similar for alcoholic patients and controls. These data suggest that tumor necrosis factor-alpha and interleukin-1 alpha are related to some of the metabolic consequences of both acute and chronic alcohol-induced liver disease, whereas interleukin-6 is related to abnormalities seen in acute liver injury. JF - Hepatology (Baltimore, Md.) AU - Khoruts, A AU - Stahnke, L AU - McClain, C J AU - Logan, G AU - Allen, J I AD - Department of Medicine, Minneapolis Veterans Administration Medical Center, Minnesota 55417. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 267 EP - 276 VL - 13 IS - 2 SN - 0270-9139, 0270-9139 KW - Antigens, CD KW - 0 KW - HLA-DR Antigens KW - Interleukin-1 KW - Interleukin-6 KW - Receptors, Interleukin-2 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Hepatitis, Alcoholic -- blood KW - Antigens, CD -- analysis KW - Reference Values KW - Leukocytes, Mononuclear -- pathology KW - HLA-DR Antigens -- analysis KW - Receptors, Interleukin-2 -- analysis KW - Humans KW - Adult KW - Biological Assay KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Leukocytes, Mononuclear -- immunology KW - Male KW - Leukocyte Count KW - Interleukin-6 -- blood KW - Interleukin-1 -- blood KW - Tumor Necrosis Factor-alpha -- metabolism KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80445492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Circulating+tumor+necrosis+factor%2C+interleukin-1+and+interleukin-6+concentrations+in+chronic+alcoholic+patients.&rft.au=Khoruts%2C+A%3BStahnke%2C+L%3BMcClain%2C+C+J%3BLogan%2C+G%3BAllen%2C+J+I&rft.aulast=Khoruts&rft.aufirst=A&rft.date=1991-02-01&rft.volume=13&rft.issue=2&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-28 N1 - Date created - 1991-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. AN - 80440925; 1671392 AB - We wanted to establish an in vitro human model for AIDS-associated dementia and pursue the hypothesis that this disease process may be a result of soluble factors produced by HIV-infected macrophages. Human brain aggregates were prepared from nine different brain specimens, and were treated with supernatants from in vitro HIV-infected macrophages (SI), uninfected macrophages (SU), infected T cells, or macrophage-conditioned media from four AIDS patients. Seven of nine treated brains exposed to SI showed peripheral rarefaction after 1 wk of incubation that by ultrastructural analysis showed cytoplasmic vacuolation. Aggregates from two of three brain cultures treated with SI for 3 wk became smaller, an approximately 50% decrease in size. The degree of apparent toxicity in brains exposed to patient-derived macrophage supernatants paralleled the proportion of macrophages found to be expressing HIV p24. Ultrastructural abnormalities were not observed in brains treated with supernatants from HIV-infected T cells, uninfected macrophages, or LPS-activated macrophages. Levels of five neurotransmitter amino acids were decreased in comparison to the structural amino acid leucine. These findings suggest that HIV-infected macrophages, infected both in vitro as well as derived from AIDS patients' peripheral blood, produce factors that cause reproducible histochemical, ultrastructural, and functional abnormalities in human brain aggregates. JF - The Journal of clinical investigation AU - Pulliam, L AU - Herndier, B G AU - Tang, N M AU - McGrath, M S AD - Department of Laboratory Medicine, San Francisco Veterans Administration Medical Center, California 94121. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 503 EP - 512 VL - 87 IS - 2 SN - 0021-9738, 0021-9738 KW - Lipopolysaccharides KW - 0 KW - Neurotransmitter Agents KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Trypan Blue KW - I2ZWO3LS3M KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Blotting, Western KW - Cells, Cultured KW - Neurotransmitter Agents -- analysis KW - Lipopolysaccharides -- pharmacology KW - L-Lactate Dehydrogenase -- analysis KW - Humans KW - Trypan Blue -- analysis KW - Microscopy, Electron KW - Neurons -- ultrastructure KW - Macrophages -- microbiology KW - AIDS Dementia Complex -- metabolism KW - Brain -- pathology KW - HIV -- isolation & purification KW - Brain -- microbiology KW - Brain -- metabolism KW - AIDS Dementia Complex -- pathology KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80440925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Human+immunodeficiency+virus-infected+macrophages+produce+soluble+factors+that+cause+histological+and+neurochemical+alterations+in+cultured+human+brains.&rft.au=Pulliam%2C+L%3BHerndier%2C+B+G%3BTang%2C+N+M%3BMcGrath%2C+M+S&rft.aulast=Pulliam&rft.aufirst=L&rft.date=1991-02-01&rft.volume=87&rft.issue=2&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-11 N1 - Date created - 1991-03-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1988 Dec;82(6):2097-105 [3264291] Science. 1989 May 19;244(4906):798-800 [2567056] J Neurosci Methods. 1987 May;20(1):83-90 [2884353] Nature. 1988 Oct 13;335(6191):639-42 [2845276] Ann Neurol. 1986 Jun;19(6):525-35 [3014994] N Engl J Med. 1985 Dec 12;313(24):1493-7 [2999591] J Neurochem. 1985 Apr;44(4):1242-51 [2983029] Science. 1985 Jan 11;227(4683):177-82 [2981429] Science. 1985 Jan 11;227(4683):173-7 [2981428] AIDS Res Hum Retroviruses. 1987 Summer;3(2):135-45 [3113464] J Infect Dis. 1988 Nov;158(5):1079-83 [3053922] Proc Natl Acad Sci U S A. 1989 Jan;86(2):621-5 [2536171] Proc Natl Acad Sci U S A. 1989 Apr;86(8):2844-8 [2704750] J Neurosci Res. 1988 Oct-Dec;21(2-4):521-30 [3216435] Am J Pathol. 1987 Mar;126(3):403-10 [3548405] Proc Natl Acad Sci U S A. 1986 Feb;83(3):822-6 [3511475] Proc Natl Acad Sci U S A. 1987 May;84(10):3526-30 [3472222] Ann Intern Med. 1987 May;106(5):692-5 [3646001] J Virol. 1987 Apr;61(4):1244-7 [3644020] Science. 1986 Oct 31;234(4776):566-74 [3764429] J Neurochem. 1983 Aug;41(2):506-15 [6308162] Anal Biochem. 1973 Nov;56(1):275-82 [4358018] J Neurochem. 1967 Dec;14(12):1167-74 [4294951] Lancet. 1985 Sep 14;2(8455):586-8 [2863599] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. AN - 80437029; 1992482 AB - To define the sites in the extracellular domain of the human thyrotropin (TSH) receptor that are involved in TSH binding and signal transduction we constructed chimeric thyrotropin-luteinizing hormone/chorionic gonadotropin (TSH-LH/CG) receptors. The extracellular domain of the human TSH receptor was divided into five regions that were replaced, either singly or in various combinations, with homologous regions of the rat LH/CG receptor. The chimeric receptors were stably expressed in Chinese hamster ovary cells. The data obtained suggest that the carboxyl region of the extracellular domain (amino acid residues 261-418) and particularly the middle region (residues 171-260) play a role in signal transduction. The possibility is also raised of an interaction between the amino and carboxyl regions of the extracellular domain in the process of signal transduction. With respect to hormone binding, substitution of the entire extracellular domain of the LH/CG receptor for the corresponding region of the TSH receptor resulted in high-affinity human CG binding with complete loss of TSH binding. Surprisingly, however, there was at least one chimera with a substitution at each of the five domains that still retained high-affinity TSH binding. Substitution of residues 1-170 of the TSH receptor with the corresponding region of the LH/CG receptor was associated with the retention of high-affinity TSH binding but ligand specificity was lost in that TSH and human CG could interact functionally with the receptor. In summary, these studies suggest that the middle region and carboxyl half of the extracellular domain of the TSH receptor are involved in signal transduction and that the TSH-binding region is likely to span the entire extracellular domain, with multiple discontinuous contact sites. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Nagayama, Y AU - Wadsworth, H L AU - Chazenbalk, G D AU - Russo, D AU - Seto, P AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1991/02/01/ PY - 1991 DA - 1991 Feb 01 SP - 902 EP - 905 VL - 88 IS - 3 SN - 0027-8424, 0027-8424 KW - Chorionic Gonadotropin KW - 0 KW - Receptors, LH KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Animals KW - Chimera KW - Transfection KW - Kinetics KW - Humans KW - Chorionic Gonadotropin -- metabolism KW - Restriction Mapping KW - DNA -- genetics KW - Thyrotropin -- metabolism KW - Cell Line KW - Protein Conformation KW - Receptors, Thyrotropin -- metabolism KW - Receptors, LH -- genetics KW - Receptors, LH -- metabolism KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80437029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Thyrotropin-luteinizing+hormone%2Fchorionic+gonadotropin+receptor+extracellular+domain+chimeras+as+probes+for+thyrotropin+receptor+function.&rft.au=Nagayama%2C+Y%3BWadsworth%2C+H+L%3BChazenbalk%2C+G+D%3BRusso%2C+D%3BSeto%2C+P%3BRapoport%2C+B&rft.aulast=Nagayama&rft.aufirst=Y&rft.date=1991-02-01&rft.volume=88&rft.issue=3&rft.spage=902&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-08 N1 - Date created - 1991-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1990 Jul 1;145(1):331-6 [1694207] Cell. 1990 May 18;61(4):553-6 [1693095] Endocrinology. 1990 Sep;127(3):1240-4 [2167212] Science. 1990 Sep 21;249(4975):1423-5 [2169649] Mol Endocrinol. 1990 Apr;4(4):525-30 [2126341] Endocrinology. 1974 Nov;95(5):1228-33 [4372033] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Biol Chem. 1984 Dec 25;259(24):15078-84 [6096357] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] Proc Natl Acad Sci U S A. 1985 Apr;82(7):1906-10 [3856868] Mol Cell Endocrinol. 1985 Aug;42(1):21-7 [2411613] Proc Natl Acad Sci U S A. 1986 Oct;83(20):7683-7 [3484330] Proc Natl Acad Sci U S A. 1987 Aug;84(16):5615-9 [3303030] Mol Cell Biol. 1987 Aug;7(8):2745-52 [3670292] Science. 1988 Jan 29;239(4839):487-91 [2448875] Cell. 1988 Jan 29;52(2):269-79 [2449285] Science. 1988 Jun 3;240(4857):1310-6 [2836950] Science. 1989 Mar 10;243(4896):1330-6 [2466339] FASEB J. 1989 May;3(7):1825-32 [2541037] Science. 1989 Jun 2;244(4908):1081-5 [2471267] Science. 1989 Aug 4;245(4917):494-9 [2502842] Science. 1989 Aug 4;245(4917):525-8 [2502844] Science. 1989 Dec 22;246(4937):1620-2 [2556796] Biochem Biophys Res Commun. 1989 Dec 29;165(3):1184-90 [2558651] Biochem Biophys Res Commun. 1989 Dec 29;165(3):1250-5 [2610690] Biochem Biophys Res Commun. 1990 Jan 15;166(1):394-403 [2302212] Science. 1990 Mar 23;247(4949 Pt 1):1461-5 [2321008] J Clin Endocrinol Metab. 1990 Jul;71(1):53-9 [1695226] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of growth of experimental prostate cancer with sustained delivery systems (microcapsules and microgranules) of the luteinizing hormone-releasing hormone antagonist SB-75. AN - 80436231; 1992476 AB - Inhibitory effects of the sustained delivery systems (microcapsules and microgranules) of a potent antagonist of luteinizing hormone-releasing hormone N-Ac-[3-(2-naphthyl)-D-alanine1, 4-chloro-D-phenylalanine2, 3-(3-pyridyl)-D-alanine3, D-citrulline6, D-alanine10]LH-RH (SB-75) on the growth of experimental prostate cancers were investigated. In the first experiment, three doses of a microcapsule preparation releasing 23.8, 47.6, and 71.4 micrograms of antagonist SB-75 per day were compared with microcapsules of agonist [D-Trp6]LH-RH liberating 25 micrograms/day in rats bearing Dunning R3327H transplantable prostate carcinoma. During 8 weeks of treatment, tumor growth was decreased by [D-Trp6]LH-RH and all three doses of SB-75 as compared to untreated controls. The highest dose of SB-75 (71.4 micrograms/day) caused a greater inhibition of prostate cancer growth than [D-Trp6]LH-RH as based on measurement of tumor volume and percentage change in tumor volume. Doses of 23.8 and 47.6 micrograms of SB-75 per day induced a partial and submaximal decrease, respectively, in tumor weight and volume. Tumor doubling time was the longest (50 days) with the high dose of SB-75 vs. 15 days for controls. The body weights were unchanged. The weights of testes, seminal vesicles, and ventral prostate were greatly reduced in all three groups that received SB-75, and testosterone levels were decreased to nondetectable values in the case of the two higher doses of SB-75. LH levels were also diminished. Similar results were obtained in the second experiment, in which the animals were treated for a period of 8 weeks with microgranules of SB-75. Therapy with microgranules of SB-75 significantly decreased tumor growth as measured by the final tumor volume, the percentage change from the initial tumor volume, and the reduction in tumor weight. The results indicate that antagonist SB-75, released from sustained delivery systems, can produce a state of chemical castration and effectively inhibit the growth of experimental prostate cancers. The efficacy of the antagonist SB-75 in inhibiting androgen-dependent Dunning prostatic carcinoma and the absence of side effects suggest its possible usefulness for the treatment of hormone-sensitive tumors. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Korkut, E AU - Bokser, L AU - Comaru-Schally, A M AU - Groot, K AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1991/02/01/ PY - 1991 DA - 1991 Feb 01 SP - 844 EP - 848 VL - 88 IS - 3 SN - 0027-8424, 0027-8424 KW - Capsules KW - 0 KW - Delayed-Action Preparations KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - cetrorelix KW - OON1HFZ4BA KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Male KW - Organ Size -- drug effects KW - Prostatic Neoplasms -- pathology KW - Gonadotropin-Releasing Hormone -- blood KW - Gonadotropin-Releasing Hormone -- antagonists & inhibitors KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Gonadotropin-Releasing Hormone -- toxicity KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80436231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Inhibition+of+growth+of+experimental+prostate+cancer+with+sustained+delivery+systems+%28microcapsules+and+microgranules%29+of+the+luteinizing+hormone-releasing+hormone+antagonist+SB-75.&rft.au=Korkut%2C+E%3BBokser%2C+L%3BComaru-Schally%2C+A+M%3BGroot%2C+K%3BSchally%2C+A+V&rft.aulast=Korkut&rft.aufirst=E&rft.date=1991-02-01&rft.volume=88&rft.issue=3&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-08 N1 - Date created - 1991-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 1979 Jun;31(6):677-82 [376360] J Natl Cancer Inst. 1990 Mar 21;82(6):513-7 [2156080] Proc Natl Acad Sci U S A. 1981 Oct;78(10):6509-12 [6458815] Proc Natl Acad Sci U S A. 1982 Feb;79(4):1273-6 [6803239] Proc Natl Acad Sci U S A. 1982 Mar;79(5):1658-62 [6461861] FEBS Lett. 1983 Apr 5;154(1):92-6 [6299799] Prostate. 1983;4(6):545-52 [6226942] Prostate. 1984;5(1):1-17 [6694914] Proc Natl Acad Sci U S A. 1984 Sep;81(18):5845-8 [6237365] Proc Natl Acad Sci U S A. 1985 Apr;82(8):2498-502 [3157990] Lancet. 1985 Nov 30;2(8466):1201-5 [2866289] Proc Natl Acad Sci U S A. 1986 Nov;83(22):8764-8 [2946045] Prog Clin Biol Res. 1987;243A:173-97 [2889215] Proc Natl Acad Sci U S A. 1987 Oct;84(20):7275-9 [2890164] Proc Natl Acad Sci U S A. 1988 Mar;85(5):1637-41 [3278323] Proc Natl Acad Sci U S A. 1988 Aug;85(15):5688-92 [2899894] Arzneimittelforschung. 1990 Feb;40(2 Pt 1):111-8 [2110458] Cancer Res. 1990 Jun 15;50(12):3716-21 [2160323] Cancer. 1990 May 15;65(10):2279-90 [1971771] Br J Cancer. 1990 Jul;62(1):96-9 [2117967] Int J Pept Protein Res. 1990 Jun;35(6):557-65 [2144847] Proc Natl Acad Sci U S A. 1990 Sep;87(18):7100-4 [2205853] Endocrinology. 1990 Dec;127(6):3052-60 [2174343] Proc Natl Acad Sci U S A. 1989 Mar;86(5):1648-51 [2646641] Int J Pept Protein Res. 1988 Dec;32(6):425-35 [2469662] Prostate. 1989;14(3):191-208 [2471961] Proc Natl Acad Sci U S A. 1989 Aug;86(16):6313-7 [2548206] Proc Natl Acad Sci U S A. 1989 Aug;86(16):6318-22 [2548207] Cancer Res. 1989 Nov 15;49(22):6290-4 [2804976] J Clin Invest. 1981 Sep;68(3):819-22 [6456277] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recurrent rhabdomyolysis in association with cocaine use. AN - 80431397; 1990467 AB - As the popularity of cocaine increases in our society, so does the frequency and variety of medical complications associated with its use. A growing number of cases have implicated cocaine use in the development of rhabdomyolysis and its complication, acute renal failure. We have reported the first case of recurrent rhabdomyolysis and acute renal failure directly associated with cocaine use. Although adulterants might cause muscle damage, we believe cocaine should be added to the list of drugs that are capable of producing rhabdomyolysis. JF - Southern medical journal AU - Horst, E AU - Bennett, R L AU - Barrett, O AD - Department of Medicine, WJB Dorn Veterans Administration Hospital, Columbia, SC. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 269 EP - 270 VL - 84 IS - 2 SN - 0038-4348, 0038-4348 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Adult KW - Recurrence KW - Male KW - Rhabdomyolysis -- chemically induced KW - Substance Abuse, Intravenous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80431397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Recurrent+rhabdomyolysis+in+association+with+cocaine+use.&rft.au=Horst%2C+E%3BBennett%2C+R+L%3BBarrett%2C+O&rft.aulast=Horst&rft.aufirst=E&rft.date=1991-02-01&rft.volume=84&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-07 N1 - Date created - 1991-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes. AN - 80423249; 1899124 AB - Glyburide and tolbutamide, at concentrations of 20 to 40 mumol/L and 1 to 2 mmol/L, respectively, stimulated glucose transport in rat adipocytes. Concomitantly, protein kinase C was activated, as evidenced by translocation of immunoreactive enzyme from cytosol to membranes. Glucose transport effects of the sulfonylureas were blocked by three inhibitors of protein kinase C (H-7, staurosporine, and sangivamycin), and by phorbol ester-induced down-regulation of protein kinase C. These findings suggest that sulfonylureas may stimulate glucose transport in rat adipocytes through activation of protein kinase C. JF - Metabolism: clinical and experimental AU - Farese, R V AU - Ishizuka, T AU - Standaert, M L AU - Cooper, D R AD - Veterans' Administration Hospital, Tampa, FL 33612. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 196 EP - 200 VL - 40 IS - 2 SN - 0026-0495, 0026-0495 KW - Insulin KW - 0 KW - Sulfonylurea Compounds KW - Tolbutamide KW - 982XCM1FOI KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Glyburide KW - SX6K58TVWC KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Tolbutamide -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Insulin -- pharmacology KW - Time Factors KW - Glyburide -- pharmacology KW - Male KW - Deoxyglucose -- metabolism KW - Biological Transport -- drug effects KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Sulfonylurea Compounds -- pharmacology KW - Adipose Tissue -- cytology KW - Glucose -- metabolism KW - Adipose Tissue -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80423249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Sulfonylureas+activate+glucose+transport+and+protein+kinase+C+in+rat+adipocytes.&rft.au=Farese%2C+R+V%3BIshizuka%2C+T%3BStandaert%2C+M+L%3BCooper%2C+D+R&rft.aulast=Farese&rft.aufirst=R&rft.date=1991-02-01&rft.volume=40&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-28 N1 - Date created - 1991-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of Depression in War-Related Posttraumatic Stress Disorder AN - 61248998; 91X7498 AB - An attempt to better characterize the affective symptoms of war-related posttraumatic stress disorder (PTSD) by assessing not only the diagnostic measures of depression, but also subjective experiences, which are believed to indicate a more lasting dimension of depression. Data were gathered on 45 male psychiatric patients at a Veteran's Administration medical center, 28 with PTSD & 17 with major depressive disorders, via the Depressive Experiences Questionnaire, used to measure dependency & feelings about self, & the Hamilton Rating Scale, assessing state measures of symptom severity. The findings suggest that the depressive dimensions of PTSD, including dependency & self-criticism, may have important clinical implications. With a more precise characterization of subtypes & dimensions of depression of PTSD patients, it might be possible to develop more specific courses of treatment. 1 Table, 25 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Southwick, Steven M AU - Yehuda, Rachel AU - Giller, Earl L AD - Dept Psychiatry West Haven Veterans' Administration Medical Center, CT 06516 Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 179 EP - 183 VL - 148 IS - 2 SN - 0002-953X, 0002-953X KW - posttraumatic stress disorder, depressive symptoms KW - scale data KW - psychiatric patients, Veterans Administration hospital KW - Veterans KW - Depression (Psychology) KW - Males KW - United States of America KW - Mental Illness KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61248998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Characterization+of+Depression+in+War-Related+Posttraumatic+Stress+Disorder&rft.au=Southwick%2C+Steven+M%3BYehuda%2C+Rachel%3BGiller%2C+Earl+L&rft.aulast=Southwick&rft.aufirst=Steven&rft.date=1991-02-01&rft.volume=148&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Veterans; Males; United States of America; Mental Illness ER - TY - JOUR T1 - Metabolism and disposition of bladder carcinogens in rat and guinea pig: possible mechanism of guinea pig resistance to bladder cancer. AN - 80361577; 1898713 AB - The metabolism and disposition of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) were studied in rat and guinea pig. Rat is susceptible whereas guinea pig is resistant to FANFT-induced bladder cancer. Rats and guinea pigs were p.o. administered either 2-[14C]ANFT or 2-[14C]FANFT (100 mg/kg), and 18-h urine and feces were collected. Tissue distribution of radiolabel was determined. In both species, the highest concentrations of radioactivity expressed as nmol/g tissue were observed in the urine and intestines. Urinary metabolites were separated by high-performance liquid chromatography and radioactivity determined by radioanalytical detection. FANFT was not detected in urine from either species under any experimental condition. More ANFT was observed in urine following FANFT than ANFT administration. This deformylation-dependent excretion of FANFT was demonstrated in both species and has been previously described as renal metabolic/excretory coupling. Less ANFT, the carcinogen more proximate than FANFT, is excreted in guinea pigs compared with rats. A unique ANFT metabolite was identified in guinea pig but not rat urine. This metabolite represented 80 and 18% of radioactivity recovered in guinea pig urine following ANFT and FANFT administration, respectively. A metabolite produced by guinea pig liver and kidney microsomes in the presence of uridine-5'-diphosphoglucuronic acid coeluted with this unique metabolite. The urinary metabolite was characterized using hydrolytic enzymes, acid hydrolysis, and mass spectrometry and identified as an ANFT-N-glucuronide. A unique UDP-glucuronosyl-transferase appears to be responsible, at least in part, for the reduced amount of free ANFT excreted by guinea pigs compared with rats. Reduced levels of urinary ANFT observed in guinea pigs may partially explain the resistance of this species to FANFT-induced bladder cancer. JF - Cancer research AU - Dawley, R M AU - Zenser, T V AU - Mattammal, M B AU - Lakshmi, V M AU - Hsu, F F AU - Davis, B B AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125. Y1 - 1991/01/15/ PY - 1991 DA - 1991 Jan 15 SP - 514 EP - 520 VL - 51 IS - 2 SN - 0008-5472, 0008-5472 KW - Carbon Radioisotopes KW - 0 KW - Carcinogens KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Index Medicus KW - Rats KW - Mass Spectrometry KW - Animals KW - Rats, Inbred F344 KW - Disease Susceptibility KW - Guinea Pigs KW - Glucuronosyltransferase -- metabolism KW - Tissue Distribution KW - Species Specificity KW - Male KW - FANFT -- pharmacokinetics KW - Carcinogens -- metabolism KW - FANFT -- analogs & derivatives KW - FANFT -- metabolism KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80361577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Metabolism+and+disposition+of+bladder+carcinogens+in+rat+and+guinea+pig%3A+possible+mechanism+of+guinea+pig+resistance+to+bladder+cancer.&rft.au=Dawley%2C+R+M%3BZenser%2C+T+V%3BMattammal%2C+M+B%3BLakshmi%2C+V+M%3BHsu%2C+F+F%3BDavis%2C+B+B&rft.aulast=Dawley&rft.aufirst=R&rft.date=1991-01-15&rft.volume=51&rft.issue=2&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prostaglandin E2 induction of monoblastic differentiation utilizes both cAMP and non-cAMP dependent signalling systems. AN - 80443397; 1847302 AB - U937 cells can be induced to express receptor for complement 5a (C5aR) by sequential 2 day treatments of cells with dihydroxyvitamin D-3 (1,25(OH)2D3) followed by prostaglandin E2. We asked whether the action of prostaglandin E2 to cause maximal C5aR expression required only activation of the cAMP-dependent protein kinase (PKA). Prostaglandin E2 dose dependently activated PKA in control and 1,25(OH)2D3 treated cells; by 4 h the PKA did not respond to further prostaglandin E2 challenge. We hypothesized that prostaglandin E2 actions transduced via PKA should be complete by 4 h; i.e., C5aR induction should be equivalent in cells treated with prostaglandin E2 for 4 h and for 2 days. All cells were treated for the first 2 days with 1,25(OH)2D3 and the second 2 days with prostaglandin E2 or cAMP analogs. C5aR number was measured after 4 days total culture. 4 h pulse treatments with agents were given at the end of the 1,25(OH)2D3 treatment. Cells exposed to a 4 h pulse of prostaglandin E2 had only 68.2 +/- 4.4% the amount of C5aR seen in cells continuously exposed to prostaglandin E2. Continuous culture with a cAMP analog pair (50 microM each of 8-thiomethyl-cAMP + N6-benzoyl-cAMP), which caused a 41.7% +/- 10.8% increase PKA activation above basal, resulted in only 51% +/- 16% of the C5aR numbers seen in cells cultured for 2 days with prostaglandin E2, where PKA remained at basal activity. We therefore concluded that C5aR expression caused by prostaglandin E2 could not be ascribed entirely to duration or degree of activation of cAMP-dependent signalling pathways. We investigated the possibility that the calcium sensitive protein kinase C was involved. Cytoplasmic protein kinase C was increased 154% +/- 14% above control in cells treated with sequential 2 days treatments of 1,25(OH)2D3 and prostaglandin E2. A 147% +/- 2% increase in membrane associated protein kinase C was also seen 10 min after phorbol myristate acetate stimulation in the above treatment group. Finally, phorbol myristate acetate augmented the C5aR induction caused by cAMP analog. We propose that the mechanism of prostaglandin E2 synergism with 1,25(OH)2D3 in causing C5aR induction in U937 cells includes signal transduction not only by the cAMP cascade, but also via protein kinase C modulated pathways. JF - Biochimica et biophysica acta AU - Rubin, J E AU - Titus, L AU - Nanes, M S AD - Research Service, Veterans Administration Medical Center, Clairmont, GA. Y1 - 1991/01/10/ PY - 1991 DA - 1991 Jan 10 SP - 87 EP - 95 VL - 1091 IS - 1 SN - 0006-3002, 0006-3002 KW - Isoenzymes KW - 0 KW - Receptor, Anaphylatoxin C5a KW - Receptors, Complement KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcitriol KW - FXC9231JVH KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Protein Kinases -- physiology KW - Humans KW - Calcitriol -- physiology KW - Cell Differentiation -- physiology KW - Isoenzymes -- physiology KW - Signal Transduction -- drug effects KW - Calcium -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Up-Regulation KW - Protein Kinase C -- physiology KW - Cell Differentiation -- drug effects KW - Time Factors KW - Cell Line KW - Monocytes -- cytology KW - Dinoprostone -- physiology KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Receptors, Complement -- biosynthesis KW - Cyclic AMP -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80443397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Prostaglandin+E2+induction+of+monoblastic+differentiation+utilizes+both+cAMP+and+non-cAMP+dependent+signalling+systems.&rft.au=Rubin%2C+J+E%3BTitus%2C+L%3BNanes%2C+M+S&rft.aulast=Rubin&rft.aufirst=J&rft.date=1991-01-10&rft.volume=1091&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. AN - 80370829; 1845968 AB - Regulation of phosphate uptake was studied in a HeLa cell line after transfection with DNA encoding the human 5-HT1A receptor. In these cells, 5-HT stimulates sodium-dependent phosphate uptake via protein kinase C activation. Endogenous histamine H1 receptors (739 +/- 20 fmol/mg protein) were identified with [3H]pyrilamine. Histamine (i) stimulated phosphoinositide hydrolysis (EC50 = 8.6 +/- 4.1 microM), (ii) activated protein kinase C (2.4-fold increase in activity), and (iii) increased phosphate uptake (EC50 = 3.2 +/- 1.8 microM) by increasing maximal transport (Vmax(basal) = 6.2 +/- 0.3 versus Vmax(histamine) = 9.1 +/- 0.4) without changing the affinity of the transport process for phosphate. Prolonged treatment with 16 microM phorbol 12-myristate 13-acetate completely blocked protein kinase C activation and markedly attenuated the stimulation of phosphate uptake induced by histamine, establishing that 5-HT and histamine stimulate phosphate uptake through the common pathway of protein kinase C activation. The linkages of the histamine H1 and 5-HT1A receptors to G protein pools were assessed in two ways. (i) The stimulation of phosphoinositide hydrolysis, protein kinase C activity, and phosphate uptake associated with histamine were insensitive to pertussis toxin, whereas those associated with 5-HT were very sensitive to pertussis toxin. (ii) The stimulation of phosphoinositide hydrolysis, protein kinase C activity, and phosphate uptake induced by histamine and 5-HT were additive. These findings suggest that distinct receptor types can stimulate phosphoinositide hydrolysis, protein kinase C, and phosphate uptake in an additive fashion through distinct pools of G proteins in a single cell type. JF - The Journal of biological chemistry AU - Raymond, J R AU - Albers, F J AU - Middleton, J P AU - Lefkowitz, R J AU - Caron, M G AU - Obeid, L M AU - Dennis, V W AD - Medical Service (Nephrology Section), Durham Veterans Administration Medical Center, North Carolina. Y1 - 1991/01/05/ PY - 1991 DA - 1991 Jan 05 SP - 372 EP - 379 VL - 266 IS - 1 SN - 0021-9258, 0021-9258 KW - Phosphates KW - 0 KW - Phosphatidylinositols KW - RNA, Messenger KW - Receptors, Histamine H1 KW - Receptors, Serotonin KW - Virulence Factors, Bordetella KW - Serotonin KW - 333DO1RDJY KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Histamine KW - 820484N8I3 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Protein Kinase C KW - EC 2.7.11.13 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Pyrilamine KW - HPE317O9TL KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - HeLa Cells -- metabolism KW - Blotting, Northern KW - HeLa Cells -- drug effects KW - Humans KW - RNA, Messenger -- drug effects KW - Biological Transport KW - RNA, Messenger -- genetics KW - Hydrolysis KW - Pyrilamine -- metabolism KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Virulence Factors, Bordetella -- pharmacology KW - Down-Regulation KW - Phosphorylation KW - Transfection KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - RNA, Messenger -- isolation & purification KW - Protein Kinase C -- metabolism KW - Phosphates -- metabolism KW - Serotonin -- pharmacology KW - Phosphatidylinositols -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Receptors, Histamine H1 -- genetics KW - Histamine -- pharmacology KW - GTP-Binding Proteins -- metabolism KW - Receptors, Serotonin -- metabolism KW - Receptors, Serotonin -- genetics KW - Receptors, Histamine H1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80370829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=5-HT1A+and+histamine+H1+receptors+in+HeLa+cells+stimulate+phosphoinositide+hydrolysis+and+phosphate+uptake+via+distinct+G+protein+pools.&rft.au=Raymond%2C+J+R%3BAlbers%2C+F+J%3BMiddleton%2C+J+P%3BLefkowitz%2C+R+J%3BCaron%2C+M+G%3BObeid%2C+L+M%3BDennis%2C+V+W&rft.aulast=Raymond&rft.aufirst=J&rft.date=1991-01-05&rft.volume=266&rft.issue=1&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-14 N1 - Date created - 1991-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reliability and validity of a combat exposure index for Vietnam era veterans. AN - 85255889; pmid-2026782 AB - The reliability and validity of a self-report measure of combat exposure are examined in a cohort of male-male twin pairs who served in the military during the Vietnam era. Test-retest reliability for a five-level ordinal index of combat exposure is assessed by use of 192 duplicate sets of responses. The chance-corrected proportion in agreement (as measured by the kappa coefficient) is .84. As a measure of criterion-related validity, the combat index is correlated with the award of combat-related military medals ascertained from the military records. The probability of receiving a Purple Heart, Bronze Star, Commendation Medal and Combat Infantry Badge is associated strongly with the combat exposure index. These results show that this simple index is a reliable and valid measure of combat exposure. JF - Journal of Clinical Psychology AU - Janes, G R AU - Goldberg, J AU - Eisen, S A AU - True, W R AD - Hines Veterans Administration Cooperative Studies Program Coordinating Center, Illinois. PY - 1991 SP - 80 EP - 86 VL - 47 IS - 1 SN - 0021-9762, 0021-9762 KW - Veterans KW - Combat Disorders KW - Personality Tests KW - Human KW - Adult KW - Diseases in Twins KW - Support, U.S. Gov't, Non-P.H.S. KW - Psychometrics KW - Male KW - Vietnam UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85255889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Reliability+and+validity+of+a+combat+exposure+index+for+Vietnam+era+veterans.&rft.au=Janes%2C+G+R%3BGoldberg%2C+J%3BEisen%2C+S+A%3BTrue%2C+W+R&rft.aulast=Janes&rft.aufirst=G&rft.date=1991-01-01&rft.volume=47&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The clinical significance and pathophysiology of stress-related gastric mucosal hemorrhage. AN - 85201174; pmid-1885901 AB - Critically ill patients admitted to intensive care units (ICUs) develop a spectrum of gastroduodenal mucosal lesions that may result in mucosal hemorrhage and subsequent morbidity and mortality. Although stress-related mucosal lesions may be detected endoscopically in most critically ill patients, the incidence of clinically significant bleeding from these lesions is difficult to establish because of the heterogeneity in patient populations, the definitions of bleeding, and the methods of monitoring in various studies. Bleeding occurs overall in approximately 16% of patients not receiving prophylaxis, but the incidence of life-threatening hemorrhage appears to be much lower (less than 6%). In light of the increasing use of pharmacologic prophylaxis in ICUs, the clinical impact of stress-related bleeding and its prophylaxis is discussed in terms of bleeding incidence, morbidity and mortality, cost, and potential side effects. The pathophysiology of stress-related mucosal ulceration involves the complex interaction of gastric luminal factors, alterations in blood flow and intramucosal pH, and alterations in numerous factors that are normally responsible for maintaining an intact mucosa. The pathophysiology of stress ulceration is discussed, with an emphasis on cause-and-effect relationships, evolving areas of investigation, and implications for prophylaxis and treatment. JF - Journal of Clinical Gastroenterology AU - Bresalier, R S AD - Department of Medicine (Gastroenterology), Veterans Administration Medical Center, San Francisco, California 94121. PY - 1991 SP - S35 EP - S43 VL - 13 Suppl 2 SN - 0192-0790, 0192-0790 KW - Stomach Diseases KW - Human KW - Gastric Mucosa KW - Animal KW - Gastrointestinal Hemorrhage KW - Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=The+clinical+significance+and+pathophysiology+of+stress-related+gastric+mucosal+hemorrhage.&rft.au=Bresalier%2C+R+S&rft.aulast=Bresalier&rft.aufirst=R&rft.date=1991-01-01&rft.volume=13+Suppl+2&rft.issue=&rft.spage=S35&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of head extension on equilibrium in normal subjects. AN - 85174544; pmid-1985528 AB - A dynamic posturography system was used to test the effect of 55 degrees head extension on postural sway in 20 normal subjects. There was a highly significant increase in sway with head extension under two conditions; in both, the support surface moves proportionally to body sway angle (sway-referenced feedback). The largest increase in sway occurred when the eyes were closed and the support surface was sway-referenced. This latter condition removes vision, reduces the effectiveness of ankle proprioception, and forces the subject to depend mostly on vestibular information for equilibrium. We suggest that head extension increases sway because the utricular otoliths are put into a disadvantageous position. This may be another example of the role of utricular input in the control of balance. JF - The Annals of Otology, Rhinology, and Laryngology AU - Jackson, R T AU - Epstein, C M AD - Rehabilitation Research and Development Center, Atlanta Veterans Administration Medical Center, GA. PY - 1991 SP - 63 EP - 67 VL - 100 IS - 1 SN - 0003-4894, 0003-4894 KW - Otolithic Membrane KW - Head KW - Musculoskeletal Equilibrium KW - Vision KW - Humans KW - Adult KW - Research Support, U.S. Gov't, Non-P.H.S. KW - Aged KW - Middle Aged KW - Female KW - Male KW - Posture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85174544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Effect+of+head+extension+on+equilibrium+in+normal+subjects.&rft.au=Jackson%2C+R+T%3BEpstein%2C+C+M&rft.aulast=Jackson&rft.aufirst=R&rft.date=1991-01-01&rft.volume=100&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Fluorescence localization of early colonic cancer in the rat by hematoporphyrin derivative. AN - 80712611; 1861565 AB - Laser excitation of hematoporphyrin derivatives (HPD) localizing in tumors of the tracheobronchial tree and bladder is useful in the identification and treatment of those tumors. A comparable utility for HPD in the endoscopic localization of colonic tumors may be possible. In this study the ability of HPD to identify 1,2 dimethylhydrazine (DMH) induced colon cancer in rats is evaluated. A total of 111 rats were studied with HPD. Sixty-nine rats received weekly injections of DMH (20 mg/kg) and 42 received injections of the vehicle alone. Twenty-four hours after the intravenous injection of 5 mg/kg of HPD, 18 DMH-induced tumors were identified by visual fluorescence using excitation by either a blue light (390-436 nm) or an argon laser (488 and 514 nm). This represented 100% of the visually or microscopically detected tumors. Seventy-five fluorescent areas were noted that did not contain evidence of cancer. The majority (63) of false positive areas contained lymphoid follicles. All but 2 false positive areas (73/75, 97%, p less than .001) were seen in DMH-treated animals, suggesting that they were an artifact of DMH treatment. HPD fluorescence did not identify microscopic dysplasia. We conclude that HPD fluorescence is an effective method of identifying early colonic cancer and may have a potential clinical role in patients at high risk for colorectal cancer. JF - Lasers in surgery and medicine AU - Bjorkman, D J AU - Samowitz, W S AU - Brigham, E J AU - Peterson, B J AU - Straight, R C AD - Utah Laser Institute, Veterans Administration Medical Center, Salt Lake City. Y1 - 1991 PY - 1991 DA - 1991 SP - 263 EP - 270 VL - 11 IS - 3 SN - 0196-8092, 0196-8092 KW - Dimethylhydrazines KW - 0 KW - Hematoporphyrins KW - 1,2-Dimethylhydrazine KW - IX068S9745 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Fluorescence KW - Female KW - False Positive Reactions KW - Rectal Neoplasms -- chemically induced KW - Rectal Neoplasms -- pathology KW - Rectal Neoplasms -- diagnosis KW - Lasers KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Colonic Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80712611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+surgery+and+medicine&rft.atitle=Fluorescence+localization+of+early+colonic+cancer+in+the+rat+by+hematoporphyrin+derivative.&rft.au=Bjorkman%2C+D+J%3BSamowitz%2C+W+S%3BBrigham%2C+E+J%3BPeterson%2C+B+J%3BStraight%2C+R+C&rft.aulast=Bjorkman&rft.aufirst=D&rft.date=1991-01-01&rft.volume=11&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Lasers+in+surgery+and+medicine&rft.issn=01968092&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclosporine-induced alterations in the hypothalamic hypophyseal gonadal axis in transplant patients. AN - 80703363; 1906995 AB - We evaluated the response of 20 male patients, 13 cadaveric kidney and 7 heart transplant recipients, to the administration of 100 micrograms GnRH (gonadotropin-releasing hormone) and 500 micrograms TRH (thyrotropic-releasing hormone). All of the heart transplant recipients and 7 of the kidney transplant patients were receiving a combination of cyclosporine, azathioprine and prednisone; while the 6 remaining kidney transplant patients received azathioprine and prednisone. The patients receiving cyclosporine had decreased plasma levels of prolactin, and manifested a blunted response to TRH administration for prolactin and TSH. The heart transplant patients had a blunted response of LH and FSH to the administration of GnRH. The levels of testosterone were found to be low in all patients regardless of the immunosuppressant therapy. Despite the low testosterone levels, no increment in the concentration of LH or FSH was present. Intramuscular administration of HCG (human chorionic gonadotropin) (Ayerst Laboratories, New York, N.Y.) failed to increase the testosterone concentration in 5 of 6 patients with renal transplants, 3 taking cyclosporine and 3 taking azathioprine. This study suggests that cyclosporine has a selective effect on the hypothalamus and/or hypophysis, resulting in lower baseline levels of plasma prolactin and a pituitary insensitivity to TRH administration. In addition, FSH and LH were low or normal in the presence of low testosterone levels, suggesting that the hypothalamic pituitary gonadal axis is impaired. Furthermore, there may be a direct toxic effect of the immunosuppressant medications on the gonads, manifested as lower testosterone levels and inability to respond to the administration of HCG. JF - Nephron AU - Ramirez, G AU - Narvarte, J AU - Bittle, P A AU - Ayers-Chastain, C AU - Dean, S E AD - Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, Fla. Y1 - 1991 PY - 1991 DA - 1991 SP - 27 EP - 32 VL - 58 IS - 1 SN - 1660-8151, 1660-8151 KW - Chorionic Gonadotropin KW - 0 KW - Cyclosporins KW - Hormones KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Azathioprine KW - MRK240IY2L KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Drug Therapy, Combination KW - Prednisone -- adverse effects KW - Azathioprine -- adverse effects KW - Humans KW - Azathioprine -- administration & dosage KW - Adult KW - Hormones -- blood KW - Middle Aged KW - Radioimmunoassay KW - Prednisone -- administration & dosage KW - Male KW - Kidney Transplantation -- pathology KW - Cyclosporins -- adverse effects KW - Hypothalamo-Hypophyseal System -- drug effects KW - Testis -- drug effects KW - Cyclosporins -- administration & dosage KW - Heart Transplantation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80703363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Cyclosporine-induced+alterations+in+the+hypothalamic+hypophyseal+gonadal+axis+in+transplant+patients.&rft.au=Ramirez%2C+G%3BNarvarte%2C+J%3BBittle%2C+P+A%3BAyers-Chastain%2C+C%3BDean%2C+S+E&rft.aulast=Ramirez&rft.aufirst=G&rft.date=1991-01-01&rft.volume=58&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-27 N1 - Date created - 1991-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of C5 and T-cell receptor Vb genes in susceptibility to collagen-induced arthritis. AN - 80703357; 1855815 AB - Collagen-induced arthritis (CIA) is a rodent arthritis model in which immunization with heterologous type II collagen induces an inflammatory polyarthritis. Susceptibility to the disease is mediated by major histocompatibility complex (MHC) genes as well as genes at other loci. Previous studies of the SWR/J mouse strain, which is resistant to CIA despite bearing the susceptible H-2q haplotype, have suggested that this resistance is the result of a deletion of T-cell receptor (Tcr) Vb gene segments which is carried by this strain. Other studies have implicated a deficiency in complement component C5 as the cause for the resistance. In order to assess the relative importance of these two genes in susceptibility to CIA, and to provide an estimate of the number of independent genes involved in the disease, we analyzed 196 F2 progeny of a (DBA/1 x SWR/J) cross for arthritis susceptibility, and expression of both C5 and Tcr genes. Thirty of the F2 progeny developed arthritis. All of the arthritic mice had at least one copy of the wild-type C5 allele, while the Tcr-Vb haplotypes were distributed in Mendelian fashion. These results demonstrate that C5 sufficiency is an absolute requirement for CIA, but that Tcr-Vb genes located within the SWR deletion have little influence. Genetic analysis of the incidence rate suggests that there is polygenic control of susceptibility to CIA and that in addition to H-2, 5-6 other independent loci (including C5) may be involved. JF - Immunogenetics AU - Spinella, D G AU - Jeffers, J R AU - Reife, R A AU - Stuart, J M AD - Veterans Administration Medical Center, Memphis, TN 38104. Y1 - 1991 PY - 1991 DA - 1991 SP - 23 EP - 27 VL - 34 IS - 1 SN - 0093-7711, 0093-7711 KW - Complement C5 KW - 0 KW - Receptors, Antigen, T-Cell KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Genotype KW - Animals KW - Chromosome Deletion KW - Analysis of Variance KW - Disease Models, Animal KW - Mice KW - Disease Susceptibility -- immunology KW - Genetic Predisposition to Disease KW - Arthritis -- genetics KW - Arthritis -- immunology KW - Arthritis -- chemically induced KW - Complement C5 -- genetics KW - Receptors, Antigen, T-Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80703357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunogenetics&rft.atitle=The+role+of+C5+and+T-cell+receptor+Vb+genes+in+susceptibility+to+collagen-induced+arthritis.&rft.au=Spinella%2C+D+G%3BJeffers%2C+J+R%3BReife%2C+R+A%3BStuart%2C+J+M&rft.aulast=Spinella&rft.aufirst=D&rft.date=1991-01-01&rft.volume=34&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Immunogenetics&rft.issn=00937711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-26 N1 - Date created - 1991-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Immunogenetics. 1992;35(1):71-2; author reply 73-4 [1530841] Immunogenetics. 1992;35(1):69-70 [1530840] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of EGF receptor protooncogene expression by growth factors and hormones in human breast carcinoma cells. AN - 80698917; 1677274 AB - In this review I summarize the experimental data in favor of the notion that control of epidermal growth factor (EGF) receptor (R) and/or c-erbB-2 protooncogene expression by specific autocrine growth factors and certain classical endocrine hormones serves as a transducer of extracellular signals that ultimately lead to growth responses in breast carcinoma cells. I summarize some new results on the role of epidermal growth factor (EGF), transforming growth factor (TGF) alpha, and TGF beta in the control of EGF-R protooncogene expression in human breast carcinoma cells. Furthermore, the data embracing the hypothesis that the growth actions of hormone receptors that are homologous to the v-erbA oncogene (estrogens, progesterone, thyroid hormones, retinoic acid, and vitamin D) are mediated, in part, by modulating EGF-R and/or c-erbB-2 protooncogene transcription are reviewed. Finally, I develop the theme that cooperation of certain c-erb-A-related, c-erbB-2 and/or EGF-R gene products contribute to the uncontrolled growth of human mammary carcinoma cells. From the evidence reviewed, one can infer that elucidation of the molecular control of EGF-R/c-erbB-2 gene expression by c-erbA-related gene products may lead to both a better understanding of breast carcinogenesis and a new therapeutic approach directed at controlling the transcriptional responses of EGF-R/c-erbB-2 genes. JF - Critical reviews in oncogenesis AU - Fernandez-Pol, J A AD - Laboratory of Molecular Oncology, Veterans Administration Medical Center, St. Louis, MO 63106. Y1 - 1991 PY - 1991 DA - 1991 SP - 173 EP - 185 VL - 2 IS - 2 SN - 0893-9675, 0893-9675 KW - c-erbB-2 KW - c-myc KW - Biomarkers, Tumor KW - 0 KW - Estrogens KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-myc KW - Transforming Growth Factor alpha KW - Transforming Growth Factor beta KW - Triiodothyronine KW - 06LU7C9H1V KW - Cholecalciferol KW - 1C6V77QF41 KW - Progesterone KW - 4G7DS2Q64Y KW - Tretinoin KW - 5688UTC01R KW - Epidermal Growth Factor KW - 62229-50-9 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Tretinoin -- pharmacology KW - Transforming Growth Factor beta -- pharmacology KW - Triiodothyronine -- pharmacology KW - Hydrocortisone -- physiology KW - Humans KW - Epidermal Growth Factor -- pharmacology KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Proto-Oncogene Proteins -- biosynthesis KW - Progesterone -- physiology KW - Cholecalciferol -- pharmacology KW - Estrogens -- pharmacology KW - Transforming Growth Factor alpha -- pharmacology KW - Cell Division -- genetics KW - Receptor, Epidermal Growth Factor -- drug effects KW - Breast Neoplasms -- metabolism KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Receptor, Epidermal Growth Factor -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80698917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncogenesis&rft.atitle=Modulation+of+EGF+receptor+protooncogene+expression+by+growth+factors+and+hormones+in+human+breast+carcinoma+cells.&rft.au=Fernandez-Pol%2C+J+A&rft.aulast=Fernandez-Pol&rft.aufirst=J&rft.date=1991-01-01&rft.volume=2&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncogenesis&rft.issn=08939675&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-29 N1 - Date created - 1991-08-29 N1 - Date revised - 2017-01-13 N1 - Gene symbol - c-erbB-2; c-myc N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A polymer-bound elastase inhibitor is effective in preventing human neutrophil elastase-induced emphysema. AN - 80665111; 2064242 JF - Annals of the New York Academy of Sciences AU - Lucey, E C AU - Stone, P J AU - Digenis, G A AU - Snider, G L AD - Pulmonary Section, Boston Veterans Administration Medical Center, Massachusetts 02130. Y1 - 1991 PY - 1991 DA - 1991 SP - 341 EP - 342 VL - 624 SN - 0077-8923, 0077-8923 KW - Carbamates KW - 0 KW - Polymers KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Leukocyte Elastase KW - EC 3.4.21.37 KW - Index Medicus KW - Animals KW - Humans KW - Cricetinae KW - Carbamates -- pharmacology KW - Polymers -- pharmacology KW - Pancreatic Elastase -- antagonists & inhibitors KW - Pulmonary Emphysema -- chemically induced KW - Pulmonary Emphysema -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80665111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=A+polymer-bound+elastase+inhibitor+is+effective+in+preventing+human+neutrophil+elastase-induced+emphysema.&rft.au=Lucey%2C+E+C%3BStone%2C+P+J%3BDigenis%2C+G+A%3BSnider%2C+G+L&rft.aulast=Lucey&rft.aufirst=E&rft.date=1991-01-01&rft.volume=624&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-08 N1 - Date created - 1991-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reversible effects of ethanol in utero on cardiac sarcoplasmic reticulum of guinea pig offspring. AN - 80630050; 1829025 AB - The aim was to investigate the effects of chronic ethanol exposure in utero on the sarcoplasmic reticulum of the developing heart. Pregnant guinea pigs were given 2.5% ethanol in their drinking water and guinea pig lab chow from day 30 to the end of pregnancy. Control pregnant guinea pigs received regular drinking water and lab chow. Ethanol was discontinued at delivery. Cardiac calcium transport function was evaluated in isolated sarcoplasmic reticulum from offspring of ethanol treated and control guinea pigs killed at 1-3 d and 3-5 months of age. The study group consisted of 28 Camm-Hartley guinea pigs. There were 24 controls of the same species. Maternal deaths, litter size, number of stillborns, newborn body weight, and heart weight were not different in ethanol treated and control guinea pigs and their offspring. Ca2+ uptake, Ca2+ binding, and Ca2+ stimulated ATPase activity in isolated sarcoplasmic reticulum were all reduced in 1-3 d old offspring from ethanol treated mothers when compared to age matched control offspring (p less than 0.05). By 3-5 months, calcium transport in cardiac sarcoplasmic reticulum of ethanol treated offspring was similar to that of age matched control offspring. Moderate ethanol exposure in utero produced functional cardiac alterations in the newborn which were slowly reversible with abstinence from ethanol. JF - Cardiovascular research AU - Staley, N A AU - Tobin, J D AD - Laboratory Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 27 EP - 30 VL - 25 IS - 1 SN - 0008-6363, 0008-6363 KW - Ethanol KW - 3K9958V90M KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Biological Transport, Active -- drug effects KW - Animals KW - Guinea Pigs KW - Adenosine Triphosphatases -- metabolism KW - Disease Models, Animal KW - Myocardium -- metabolism KW - Female KW - Pregnancy KW - Ethanol -- adverse effects KW - Fetal Alcohol Spectrum Disorders -- metabolism KW - Sarcoplasmic Reticulum -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Heart -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80630050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+research&rft.atitle=Reversible+effects+of+ethanol+in+utero+on+cardiac+sarcoplasmic+reticulum+of+guinea+pig+offspring.&rft.au=Staley%2C+N+A%3BTobin%2C+J+D&rft.aulast=Staley&rft.aufirst=N&rft.date=1991-01-01&rft.volume=25&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+research&rft.issn=00086363&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-01 N1 - Date created - 1991-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Site-directed mutagenesis of the human thyrotropin receptor: role of asparagine-linked oligosaccharides in the expression of a functional receptor. AN - 80519623; 2017190 AB - We studied the role of glycosylation in the expression of a functional human TSH receptor. Oligonucleotide-directed mutagenesis was used to replace, separately or together, the Asn codons with Gln in each of the six potential glycosylation sites in the receptor. Recombinant wild-type and mutated TSH receptors were stably expressed in Chinese hamster ovary cells. High affinity TSH binding and the cAMP response to TSH stimulation were abolished in the receptor mutated at Asn77 as well as in the receptor mutated at all six potential glycosylation sites. In the receptor mutated at Asn113, the affinity of TSH binding was markedly decreased (Kd, 2.6 x 10(-8) 3.3 x 10(-10) M in the wild-type receptor). This affinity was too low to permit the transduction of a signal, as measured by an increase in intracellular cAMP generation. Substitution of Asn at positions 99, 177, 198, and 302 did not appreciably affect the affinity of the TSH receptor for TSH binding or its ability to mediate an increase in intracellular cAMP levels. Therefore, either these four potential glycosylation sites are not glycolysated, or alternatively, oligosaccharide chains at these positions do not play a major role in the folding, intracellular trafficking, stability, or expression of a functional receptor on the cell surface. Conversely, our data suggest that N-linked glycosylation of Asn77 and Asn113 does play a role in the expression of a biologically active TSH receptor on the cell surface. JF - Molecular endocrinology (Baltimore, Md.) AU - Russo, D AU - Chazenbalk, G D AU - Nagayama, Y AU - Wadsworth, H L AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 29 EP - 33 VL - 5 IS - 1 SN - 0888-8809, 0888-8809 KW - Codon KW - 0 KW - Oligosaccharides KW - Receptors, Thyrotropin KW - Glutamine KW - 0RH81L854J KW - Asparagine KW - 7006-34-0 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Transfection KW - Humans KW - DNA -- genetics KW - Glutamine -- genetics KW - Nucleic Acid Hybridization KW - Glycosylation KW - Thyrotropin -- metabolism KW - Signal Transduction KW - Cell Line KW - Cricetinae KW - Mutagenesis, Site-Directed KW - Receptors, Thyrotropin -- metabolism KW - Receptors, Thyrotropin -- chemistry KW - Asparagine -- genetics KW - Gene Expression KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80519623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Site-directed+mutagenesis+of+the+human+thyrotropin+receptor%3A+role+of+asparagine-linked+oligosaccharides+in+the+expression+of+a+functional+receptor.&rft.au=Russo%2C+D%3BChazenbalk%2C+G+D%3BNagayama%2C+Y%3BWadsworth%2C+H+L%3BRapoport%2C+B&rft.aulast=Russo&rft.aufirst=D&rft.date=1991-01-01&rft.volume=5&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-23 N1 - Date created - 1991-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. AN - 80517404; 2017271 AB - Chronic hemodialysis (HD) leads to significant losses of carnitine from plasma and muscle. Because L-carnitine is important in the production of energy from fatty acid oxidation (FAO) in muscle, we examined the role of carnitine replacement by administering therapeutic doses of intravenous carnitine to 14 male patients receiving HD. Placebo or carnitine was given 2 g i.v. 3 times weekly for 6 months in a double-blind manner. To evaluate long-term toxicity of carnitine, all patients subsequently received 1 g i.v. carnitine for 10 months. Patients were rated for muscle strength each week. After 6 months, definite improvement in strength occurred in 4 of 7 carnitine-treated patients and in none of 7 controls. During the subsequent 10 months of carnitine administration, no adverse effects were noted and muscle strength improved in 9 of 14 patients. Muscle biopsy was performed in 13 patients before and after the first 6 months of treatment and in 6 healthy controls. FAO and carnitine were measured in each muscle biopsy. FAO was significantly lower in both carnitine- and placebo-treated HD patients compared to healthy controls. Although carnitine therapy increased the muscle concentration of carnitine 3-fold in muscle of HD patients, muscle FAO did not increase significantly and never reached the level of healthy controls. Muscle histopathology and ultrastructure were not specific for HD myopathy. Carnitine may be useful in treating some patients with muscle weakness related to HD. JF - Nephron AU - Siami, G AU - Clinton, M E AU - Mrak, R AU - Griffis, J AU - Stone, W AD - Veterans Administration Medical Center, Section of Nephrology, Nashville, Tenn. Y1 - 1991 PY - 1991 DA - 1991 SP - 306 EP - 313 VL - 57 IS - 3 SN - 1660-8151, 1660-8151 KW - Fatty Acids KW - 0 KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Kidney Failure, Chronic -- pathology KW - Injections, Intravenous KW - Double-Blind Method KW - Kidney Failure, Chronic -- drug therapy KW - Humans KW - Muscle Contraction -- drug effects KW - Kidney Failure, Chronic -- physiopathology KW - Male KW - Fatty Acids -- metabolism KW - Carnitine -- adverse effects KW - Carnitine -- metabolism KW - Renal Dialysis KW - Muscles -- pathology KW - Muscles -- physiopathology KW - Carnitine -- administration & dosage KW - Muscles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80517404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Evaluation+of+the+effect+of+intravenous+L-carnitine+therapy+on+function%2C+structure+and+fatty+acid+metabolism+of+skeletal+muscle+in+patients+receiving+chronic+hemodialysis.&rft.au=Siami%2C+G%3BClinton%2C+M+E%3BMrak%2C+R%3BGriffis%2C+J%3BStone%2C+W&rft.aulast=Siami&rft.aufirst=G&rft.date=1991-01-01&rft.volume=57&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-23 N1 - Date created - 1991-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The relationship of cocaine to headache in polysubstance abusers. AN - 80515581; 2016163 AB - In a questionnaire survey of inpatient polysubstance abusers it was found that cocaine relieved migraine-type headaches much more often in chronic headache sufferers than in those with only occasional headaches (p less than .05). However, cocaine could also bring on headaches after several hours, both in chronic headache sufferers and in those not subject to headaches. The facts that cocaine may relieve headache immediately, and also may precipitate headaches several hours after use, suggests that the well-known vasoconstrictive actions of cocaine may be responsible. Migraineurs seem more susceptible to some of these effects of cocaine than are people without chronic headaches. JF - Headache AU - Dhopesh, V AU - Maany, I AU - Herring, C AD - Inpatient Substance Abuse Treatment and Research Unit, Philadelphia Veterans Administration Medical Center, Pennsyvania 19104. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 17 EP - 19 VL - 31 IS - 1 SN - 0017-8748, 0017-8748 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Migraine Disorders -- drug therapy KW - Humans KW - Migraine Disorders -- etiology KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Male KW - Headache -- drug therapy KW - Substance-Related Disorders -- complications KW - Headache -- etiology KW - Cocaine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80515581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Headache&rft.atitle=The+relationship+of+cocaine+to+headache+in+polysubstance+abusers.&rft.au=Dhopesh%2C+V%3BMaany%2C+I%3BHerring%2C+C&rft.aulast=Dhopesh&rft.aufirst=V&rft.date=1991-01-01&rft.volume=31&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Headache&rft.issn=00178748&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-20 N1 - Date created - 1991-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of alcoholism and smoking on platelet eicosanoid production in vitro. AN - 80497403; 2011610 AB - Ethanol induces changes in eicosanoid synthesis in blood platelets and brain tissue. Cigarette smoking also causes alterations in eicosanoid formation. This preliminary report examined in vitro platelet sonicate eicosanoid production using 14C-arachidonic acid (14C-AA) and in separate experiments, 14C-PGH2, as substrates. Radiometric thin layer chromatography (TLC) was used to identify the products formed. Eicosanoid product formation in platelet sonicates collected from 28 abstinent male alcoholics were compared to those from 11 male control subjects. All but one of the alcoholics were chronic smokers and all control subjects were non-smokers. All smokers abstained from smoking for 12 h prior to the blood collection to control for any acute effects of cigarette smoke on eicosanoid production. Significant reductions in platelet sonicate production of PGD2 and PGE2 in vitro were observed in alcoholic smokers when 14C-PGH2, but not 14C-AA, was the substrate. These reductions were predicted equally well by two variables, smoking and alcoholism, using several statistical models. This is the first investigation that controlled for the acute effects of smoking and accounted for the potential effects of cigarette smoking on platelet eicosanoid production in alcoholics. Because cigarette smoking is prevalent among alcoholics, future studies on the role of eicosanoids in alcoholism should control for smoking. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Burch, E A AU - Kadowitz, P J AU - Kotler-Cope, S AU - McNamara, D B AD - Veterans Administration Medical Center, New Orleans, LA. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 39 EP - 44 VL - 42 IS - 1 SN - 0952-3278, 0952-3278 KW - Eicosanoids KW - 0 KW - Prostaglandin Endoperoxides, Synthetic KW - Prostaglandins H KW - Ethanol KW - 3K9958V90M KW - Prostaglandin H2 KW - 42935-17-1 KW - Dinoprostone KW - K7Q1JQR04M KW - Prostaglandin D2 KW - RXY07S6CZ2 KW - Index Medicus KW - Ethanol -- adverse effects KW - Prostaglandin D2 -- metabolism KW - Humans KW - Dinoprostone -- metabolism KW - In Vitro Techniques KW - Chromatography, Thin Layer KW - Brain -- metabolism KW - Models, Biological KW - Prostaglandins H -- metabolism KW - Prostaglandin Endoperoxides, Synthetic -- metabolism KW - Male KW - Smoking -- metabolism KW - Alcoholism -- metabolism KW - Eicosanoids -- biosynthesis KW - Blood Platelets -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80497403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=The+effects+of+alcoholism+and+smoking+on+platelet+eicosanoid+production+in+vitro.&rft.au=Burch%2C+E+A%3BKadowitz%2C+P+J%3BKotler-Cope%2C+S%3BMcNamara%2C+D+B&rft.aulast=Burch&rft.aufirst=E&rft.date=1991-01-01&rft.volume=42&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-06 N1 - Date created - 1991-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pentoxifylline in the nonoperative management of intermittent claudication. AN - 80455412; 1997079 AB - To assess the clinical effectiveness of pentoxifylline (Trental) in the treatment of intermittent claudication and ischemic rest pain, 129 patients were retrospectively interviewed with respect to compliance and improvement of symptoms. Risk factors for the development of atherosclerosis were tabulated, as was the severity of symptomatic lower extremity peripheral vascular insufficiency. The duration of pentoxifylline treatment was 35.8 +/- 45.0 weeks (mean +/- 1 S.D.). Forty-eight percent of the patients discontinued pentoxifylline on their own, most commonly because of side effects (13%) or perceived lack of improvement (23%). Of those patients taking pentoxifylline for eight weeks or more (n = 110), 64% noted some improvement, with 31% reporting increased claudication distance and 52% reduced claudication pain. Pentoxifylline provided pain relief in 52% of patients with ischemic rest pain (n = 27). Neither diabetes, hypertension, concomitant antiplatelet therapy, the severity of claudication, nor pretreatment ankle-brachial Doppler pressures were related to treatment outcome. Increased daily walking exercise during treatment was associated with successful outcome (p = 0.04). Clinical response to pentoxifylline was inversely related to the number of cigarettes smoked daily in those with 1 block claudication (n = 71, p = 0.05). Pentoxifylline was not very effective in increasing reported claudication distance. This review suggests that pentoxifylline may be of value for patients with ischemic rest pain when arterial reconstruction is not possible. Whether pentoxifylline is useful adjunctive therapy for intermittent claudication requires further scrutiny. JF - Annals of vascular surgery AU - Kokesh, J AU - Kazmers, A AU - Zierler, R E AD - Department of Surgery, Seattle Veterans Administration Medical Center, Washington. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 66 EP - 70 VL - 5 IS - 1 SN - 0890-5096, 0890-5096 KW - Pentoxifylline KW - SD6QCT3TSU KW - Index Medicus KW - Smoking KW - Patient Compliance KW - Exercise Therapy KW - Combined Modality Therapy KW - Humans KW - Retrospective Studies KW - Aged KW - Male KW - Female KW - Pentoxifylline -- therapeutic use KW - Intermittent Claudication -- drug therapy KW - Intermittent Claudication -- therapy KW - Pentoxifylline -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80455412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+vascular+surgery&rft.atitle=Pentoxifylline+in+the+nonoperative+management+of+intermittent+claudication.&rft.au=Kokesh%2C+J%3BKazmers%2C+A%3BZierler%2C+R+E&rft.aulast=Kokesh&rft.aufirst=J&rft.date=1991-01-01&rft.volume=5&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Annals+of+vascular+surgery&rft.issn=08905096&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-29 N1 - Date created - 1991-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sensitivity of technetium-99m-d,1-HMPAO to radiolysis in aqueous solutions. AN - 80429872; 1988613 AB - The sensitivity of technetium-99m- (99mTc) d,l-HMPAO to radiolytically induced dissociation in aqueous solutions was investigated. It was found that cobalt-60 (60Co) gamma irradiation of solutions containing 99mTc-d,l-HMPAO with only 1600 cGy reduced the lipophilic chelates' radiochemical purity (RCP) to 50%-60%. The radiolytic sensitivity of 99mTc-meso-HMPAO is significantly lower. The results indicate that radiolytically produced intermediates limit the in vitro stability of 99mTc-d,l-HMPAO. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Tubergen, K AU - Corlija, M AU - Volkert, W A AU - Holmes, R A AD - Research Service, Harry S. Truman Veterans Administration Hospital, Columbia, Missouri. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 111 EP - 115 VL - 32 IS - 1 SN - 0161-5505, 0161-5505 KW - Cobalt Radioisotopes KW - 0 KW - Organotechnetium Compounds KW - Oximes KW - Water KW - 059QF0KO0R KW - Technetium Tc 99m Exametazime KW - 3B744AG22N KW - Index Medicus KW - Radiochemistry KW - Radiation Dosage KW - Drug Stability KW - Organotechnetium Compounds -- radiation effects KW - Oximes -- radiation effects KW - Organotechnetium Compounds -- chemistry KW - Oximes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80429872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Sensitivity+of+technetium-99m-d%2C1-HMPAO+to+radiolysis+in+aqueous+solutions.&rft.au=Tubergen%2C+K%3BCorlija%2C+M%3BVolkert%2C+W+A%3BHolmes%2C+R+A&rft.aulast=Tubergen&rft.aufirst=K&rft.date=1991-01-01&rft.volume=32&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-25 N1 - Date created - 1991-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of protein phosphatase in activation of KCl cotransport in human erythrocytes. AN - 80425872; 1846271 AB - We investigated the effects of okadaic acid, a novel highly specific inhibitor of protein phosphatases on swelling-activated transport in human erythrocytes. Nanomolar concentrations of this compound inhibited swelling-activated K transport. Complete inhibition of this transport was observed at 1 microM. Analysis of the time course of activation of K transport upon swelling revealed that okadaic acid not only decreased the final steady-state flux but also markedly increased the time lag for activation. These results suggest that okadaic acid decreases the rate constant for the conversion of KCl transporters from the resting to the active form. Okadaic acid also inhibited N-ethylmaleimide (NEM)-stimulated K transport, and this inhibition was also observed when cells were first treated with NEM before exposure to okadaic acid. The latter finding suggests that NEM activation of KCl transport is reversible and that a later step for this activation may involve the net dephosphorylation of the KCl transport protein. These results provide the first evidence that activation of KCl cotransport in human erythrocytes is regulated by phosphoprotein phosphatase. JF - The American journal of physiology AU - Kaji, D M AU - Tsukitani, Y AD - Renal Section, Veterans Administration Medical Center, Bronx 10468. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - C176 EP - C180 VL - 260 IS - 1 Pt 1 SN - 0002-9513, 0002-9513 KW - Carrier Proteins KW - 0 KW - Chlorides KW - Ethers, Cyclic KW - Symporters KW - potassium-chloride symporters KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Ethylmaleimide KW - O3C74ACM9V KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Kinetics KW - Humans KW - Hematocrit KW - Ethers, Cyclic -- pharmacology KW - Ethylmaleimide -- pharmacology KW - Erythrocytes -- drug effects KW - Potassium -- blood KW - Chlorides -- blood KW - Carrier Proteins -- blood KW - Erythrocytes -- metabolism KW - Phosphoprotein Phosphatases -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80425872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+protein+phosphatase+in+activation+of+KCl+cotransport+in+human+erythrocytes.&rft.au=Kaji%2C+D+M%3BTsukitani%2C+Y&rft.aulast=Kaji&rft.aufirst=D&rft.date=1991-01-01&rft.volume=260&rft.issue=1+Pt+1&rft.spage=C176&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Exudative retinal detachment after photodynamic injury. AN - 80414881; 1987930 AB - Exudative retinal detachments occur in a variety of retinal and choroidal diseases. We created serous retinal detachment in the cat eye by means of photodynamic injury produced by activation of intravascular rose bengal using filtered, focused light (550 nm). Fluorescein angiography later revealed focal retinal and choroidal vascular occlusion surrounded by a larger area of leakage through the pigment epithelium. Serous retinal detachments occurred rapidly, gradually enlarged over the next 3 days, and resolved in all eyes after 14 to 21 days. Histopathologic and ultrastructural features of early lesions included the accumulation of proteinaceous fluid in the subretinal space, pigment epithelial cell damage, and localized occlusion of retinal vessels and the choriocapillaris. Later changes consisted of limited regeneration of the retina and portions of the tapetum. In several respects, these experimental detachments resemble the serous retinal detachments associated with choroidal ischemia in humans, and may serve as a useful model in the study of choroidal microvascular hypoperfusion. JF - Archives of ophthalmology (Chicago, Ill. : 1960) AU - Wilson, C A AU - Royster, A J AU - Tiedeman, J S AU - Hatchell, D L AD - Veterans Administration Medical Center, Durham, NC. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 125 EP - 134 VL - 109 IS - 1 SN - 0003-9950, 0003-9950 KW - Rose Bengal KW - 1ZPG1ELY14 KW - Abridged Index Medicus KW - Index Medicus KW - Fundus Oculi KW - Animals KW - Retinal Vessels -- ultrastructure KW - Choroid -- ultrastructure KW - Choroid -- blood supply KW - Cats KW - Fluorescein Angiography KW - Disease Models, Animal KW - Pigment Epithelium of Eye -- ultrastructure KW - Male KW - Female KW - Retinal Detachment -- chemically induced KW - Retinal Detachment -- pathology KW - Exudates and Transudates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80414881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Exudative+retinal+detachment+after+photodynamic+injury.&rft.au=Wilson%2C+C+A%3BRoyster%2C+A+J%3BTiedeman%2C+J+S%3BHatchell%2C+D+L&rft.aulast=Wilson&rft.aufirst=C&rft.date=1991-01-01&rft.volume=109&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039950&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-20 N1 - Date created - 1991-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sympathetic neural contribution to salt-induced hypertension in Dahl rats. AN - 80372024; 1987017 AB - The Dahl strain provides a model for examining mechanisms involved in the genetic sensitivity or resistance to salt-induced hypertension. Dahl salt-sensitive rats develop hypertension when fed a high salt diet; Dahl salt-resistant rats remain normotensive. Based on early experiments, it was thought that hypertension in Dahl salt-sensitive rats epitomized the overriding importance of renal and humoral mechanisms in salt-induced hypertension, but studies in the past 15 years have demonstrated that alterations in sympathetic neural mechanisms also participate critically in the genetic predisposition to salt-induced hypertension in Dahl salt-sensitive rats. This article briefly reviews sympathetic neural mechanisms in Dahl rats, including evidence for a role of afferent baroreceptor as well as central neural and peripheral adrenergic mechanisms in salt-induced hypertension in Dahl salt-sensitive rats. JF - Hypertension (Dallas, Tex. : 1979) AU - Mark, A L AD - Department of Internal Medicine, University of Iowa College of Medicine, Veterans Administration Medical Center, Iowa City. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - I86 EP - I90 VL - 17 IS - 1 Suppl SN - 0194-911X, 0194-911X KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Rats KW - Pressoreceptors -- physiopathology KW - Animals KW - Peripheral Nerves -- physiopathology KW - Afferent Pathways -- physiopathology KW - Central Nervous System -- physiopathology KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Rats, Mutant Strains -- physiology KW - Sympathetic Nervous System -- physiopathology KW - Hypertension -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80372024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Sympathetic+neural+contribution+to+salt-induced+hypertension+in+Dahl+rats.&rft.au=Mark%2C+A+L&rft.aulast=Mark&rft.aufirst=A&rft.date=1991-01-01&rft.volume=17&rft.issue=1+Suppl&rft.spage=I86&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-19 N1 - Date created - 1991-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A report of fluorosis in the United States secondary to drinking well water. AN - 80359421; 1985235 AB - A 54-year-old female resident of Wellston, Okla, was found to have osteosclerosis on a routine chest roentgenogram. Subsequent investigation disclosed the cause of her osteosclerosis to be fluorosis secondary to the ingestion of well water containing 429 mumol/L of fluoride (recommended levels, 11 to 58 mumol/L). Water samples were also obtained from the 12 wells on properties adjacent to the index case. In three other wells, all at similar depths as the well of the index case, the fluoride concentration of the water was greater than 212 mumol/L. Urine samples from members of the four households who obtain their drinking water from these wells contained elevated urinary fluoride levels. Thus, fluorosis may develop in certain areas of the United States as a result of the natural occurrence of fluoride in the groundwater. Consequently, in known endemic areas, it would appear reasonable to measure the fluoride concentration of the well water at the time of drilling. JF - JAMA AU - Felsenfeld, A J AU - Roberts, M A AD - Department of Medicine, Wadsworth Veterans Administration Medical Center, Los Angeles, CA 90073. PY - 1991 SP - 486 EP - 488 VL - 265 IS - 4 SN - 0098-7484, 0098-7484 KW - Fluorides KW - Q80VPU408O KW - Abridged Index Medicus KW - Index Medicus KW - Oklahoma KW - Fluorosis, Dental -- etiology KW - Humans KW - Middle Aged KW - Female KW - Water Supply -- analysis KW - Osteosclerosis -- etiology KW - Fluorides -- analysis KW - Fluorides -- urine KW - Fluorides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80359421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=A+report+of+fluorosis+in+the+United+States+secondary+to+drinking+well+water.&rft.au=Felsenfeld%2C+A+J%3BRoberts%2C+M+A&rft.aulast=Felsenfeld&rft.aufirst=A&rft.date=1991-01-01&rft.volume=265&rft.issue=4&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Locomotor activity response to chronic ethanol treatment in selectively bred FAST and SLOW mice. AN - 72762220; 1845525 AB - FAST and SLOW mice were selectively bred for differential sensitivity to the acute locomotor stimulant effects of alcohol. On average, FAST mice are stimulated by low alcohol doses, while SLOW mice are depressed or unaffected. We report here that, with chronic treatment, SLOW mice develop tolerance to an acute depressant effect, and subsequently exhibit a stimulant response. No evidence was obtained for tolerance to alcohol's stimulant effects during chronic exposure of FAST mice. However, evidence for the development of a sensitized response was found. If locomotor stimulation reflects reinforcement, and models the alcohol-induced euphoria reported by man, perhaps the absence of tolerance development to reinforcing effects provide a strong impetus for the development of alcoholism. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Phillips, T J AU - Burkhart-Kasch, S AU - Crabbe, J C AD - Veterans Administration Medical Center Research Service (151W), Portland, OR. Y1 - 1991 PY - 1991 DA - 1991 SP - 109 EP - 113 VL - 1 SN - 1358-6173, 1358-6173 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Mice KW - Species Specificity KW - Male KW - Ethanol -- toxicity KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Alcoholism -- physiopathology KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72762220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=Locomotor+activity+response+to+chronic+ethanol+treatment+in+selectively+bred+FAST+and+SLOW+mice.&rft.au=Phillips%2C+T+J%3BBurkhart-Kasch%2C+S%3BCrabbe%2C+J+C&rft.aulast=Phillips&rft.aufirst=T&rft.date=1991-01-01&rft.volume=1&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-10-07 N1 - Date created - 1993-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tetany induced on separate occasions by administration of potassium and magnesium in a patient with hungry-bone syndrome. AN - 72751949; 1819767 AB - The case is described of a 68-year-old man whose therapy induced tetany during each of two consecutive hospital admissions. On each occasion the patient had marked hypocalcemia and hypomagnesemia, presumably as a result of the hungry-bone syndrome associated with diffuse prostatic osteoblastic metastases. During the February 1991 admission, marked hypokalemia was the principal initial concern. It seems likely that the tetany associated with the administration of KCl, without sufficient calcium, resulted from attenuation of the protection against hypocalcemia-enhanced neuromuscular excitability conferred by coexisting hypokalemia. The admission in March 1991 was prompted by the finding (without symptoms) of very low levels of both serum Mg and serum Ca. Tetany occurred during the infusion of MgSO4, without calcium. An acute decrement in plasma ionized Ca resulting from complexing of Ca with sulfate ions together with augmented urinary excretion of Ca were likely pathogenic factors. JF - Mineral and electrolyte metabolism AU - Navarro, J AU - Oster, J R AU - Gkonos, P J AU - Ruiz, J P AU - Rhamy, R K AU - Perez, G O AD - Research Service, Veterans Administration Medical Center, Miami, Fla. Y1 - 1991 PY - 1991 DA - 1991 SP - 340 EP - 344 VL - 17 IS - 5 SN - 0378-0392, 0378-0392 KW - Minerals KW - 0 KW - Magnesium KW - I38ZP9992A KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Syndrome KW - Humans KW - Aged KW - Minerals -- metabolism KW - Male KW - Osteoblasts -- metabolism KW - Tetany -- etiology KW - Hypocalcemia -- etiology KW - Hypocalcemia -- complications KW - Potassium -- adverse effects KW - Magnesium -- adverse effects KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72751949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineral+and+electrolyte+metabolism&rft.atitle=Tetany+induced+on+separate+occasions+by+administration+of+potassium+and+magnesium+in+a+patient+with+hungry-bone+syndrome.&rft.au=Navarro%2C+J%3BOster%2C+J+R%3BGkonos%2C+P+J%3BRuiz%2C+J+P%3BRhamy%2C+R+K%3BPerez%2C+G+O&rft.aulast=Navarro&rft.aufirst=J&rft.date=1991-01-01&rft.volume=17&rft.issue=5&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Mineral+and+electrolyte+metabolism&rft.issn=03780392&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-24 N1 - Date created - 1992-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potassium channels and epilepsy: evidence that the epileptogenic toxin, dendrotoxin, binds to potassium channel proteins. AN - 72724792; 1815606 AB - Dendrotoxin-I, a component of the venom of the black mamba snake, Dendroaspis polylepsis, was used to affinity purify a potassium channel from bovine brain. This dendrotoxin-I binding protein was composed of several subunits with molecular weights of 35,000, 38,000, 42,000 and 74,000. Partial sequence resulting from Edman degradation of the N-terminus of the 74 kDa subunit was identical to the predicted amino acid sequence of the N-terminus of a protein encoded by a mouse/rat homologue of the Shaker gene family of potassium channels, MK2/RBK2 (RCK5). Polyclonal antibodies raised against synthetic peptides derived from the predicted amino acid sequence of another member of this family, MK1, recognized this 74 kDa subunit. Due to extensive amino acid sequence identity between MK2 and MK1, it is likely that antibodies recognized epitopes common to both. Thus, from an immunological standpoint, either MK1, MK2, or both channel proteins could have been present in this 74 kDa band on protein blots. Closely related K+ channels in bovine brain could have copurified based on their affinity for dendrotoxin-I (DTX-I). DTX-I was shown to inhibit MK1 currents in a time and voltage independent fashion. Physiological and molecular evidence indicates the existence of many types of DTX sensitive potassium channels in the mammalian brain, however, our protein sequencing of the 74 kDa subunit has detected the presence of only one unique N-terminal sequence, identical to MK2. The possible reason for the appearance of this discrepancy is discussed. This paper represents the first report identifying one dendrotoxin binding protein in bovine brain tissue (BK2) as a delayed rectifier type of potassium channel. JF - Epilepsy research. Supplement AU - Newitt, R A AU - Houamed, K M AU - Rehm, H AU - Tempel, B L AD - Department of Medicine and Pharmacology, Veterans Administration Medical Ctr. 182-B, Seattle, WA 98108. Y1 - 1991 PY - 1991 DA - 1991 SP - 263 EP - 273 VL - 4 SN - 0922-9833, 0922-9833 KW - Carrier Proteins KW - 0 KW - Elapid Venoms KW - Neurotoxins KW - Potassium Channels KW - Receptors, Cholinergic KW - dendrotoxin receptor KW - dendrotoxin KW - 74811-93-1 KW - Index Medicus KW - Immunoblotting KW - Animals KW - Cattle KW - Molecular Sequence Data KW - Xenopus KW - Amino Acid Sequence KW - Electrophysiology KW - Receptors, Cholinergic -- genetics KW - Epilepsy -- physiopathology KW - Neurotoxins -- metabolism KW - Epilepsy -- genetics KW - Receptors, Cholinergic -- isolation & purification KW - Potassium Channels -- genetics KW - Carrier Proteins -- genetics KW - Epilepsy -- metabolism KW - Elapid Venoms -- metabolism KW - Carrier Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72724792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research.+Supplement&rft.atitle=Potassium+channels+and+epilepsy%3A+evidence+that+the+epileptogenic+toxin%2C+dendrotoxin%2C+binds+to+potassium+channel+proteins.&rft.au=Newitt%2C+R+A%3BHouamed%2C+K+M%3BRehm%2C+H%3BTempel%2C+B+L&rft.aulast=Newitt&rft.aufirst=R&rft.date=1991-01-01&rft.volume=4&rft.issue=&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research.+Supplement&rft.issn=09229833&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-01 N1 - Date created - 1992-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aluminum: effects on bone and role in the pathogenesis of renal osteodystrophy. AN - 72707260; 1813784 AB - Renal osteodystrophy is a complex disorder that can produce a variety of histologic changes in bone. Classically, excess parathyroid hormone (PTH) secretion in patients with chronic renal failure leads to the development of skeletal lesions characterized by increases in bone cell activity and by high rates of bone formation and turnover. In contrast, aluminium retention in the body in those undergoing long-term dialysis is often associated with diminished bone cell activity and bone formation. In some patients with renal osteodystrophy, both pathogenic factors may be operative. Thus the histologic features in an individual patient can represent the combined manifestations of both excess PTH secretion and bone aluminum toxicity; the relative roles of each of these two pathogenic processes must be carefully evaluated. In the current review, several pathophysiologic mechanisms of aluminum toxicity in bone are summarized. JF - Mineral and electrolyte metabolism AU - Goodman, W G AU - Duarte, M E AD - Medical Service, Veterans Administration Medical Center, Sepulveda, Calif. Y1 - 1991 PY - 1991 DA - 1991 SP - 221 EP - 232 VL - 17 IS - 4 SN - 0378-0392, 0378-0392 KW - Parathyroid Hormone KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Space life sciences KW - Calcification, Physiologic -- drug effects KW - Parathyroid Hormone -- secretion KW - Humans KW - Bone Development -- drug effects KW - Aluminum -- adverse effects KW - Chronic Kidney Disease-Mineral and Bone Disorder -- chemically induced KW - Chronic Kidney Disease-Mineral and Bone Disorder -- pathology KW - Chronic Kidney Disease-Mineral and Bone Disorder -- physiopathology KW - Bone and Bones -- pathology KW - Bone and Bones -- drug effects KW - Aluminum -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72707260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineral+and+electrolyte+metabolism&rft.atitle=Aluminum%3A+effects+on+bone+and+role+in+the+pathogenesis+of+renal+osteodystrophy.&rft.au=Goodman%2C+W+G%3BDuarte%2C+M+E&rft.aulast=Goodman&rft.aufirst=W&rft.date=1991-01-01&rft.volume=17&rft.issue=4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Mineral+and+electrolyte+metabolism&rft.issn=03780392&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-16 N1 - Date created - 1992-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of troleandomycin as a steroid-sparing agent in both asthma and chronic obstructive pulmonary disease. AN - 72705610; 1809456 AB - Troleandomycin has been reported to be useful for reducing the steroid requirement of patients with asthma. The purpose of this study was to evaluate the usefulness of troleandomycin in treating patients with steroid-dependent asthma as well as in patients with steroid-dependent chronic obstructive pulmonary disease (COPD). Twelve patients with obstructive airway disease were studied; 6 patients had a diagnosis of asthma, and 6 patients had COPD. All had failed previous attempts to reduce their dosage of steroids. Among the patients with asthma, it was possible to taper methylprednisolone dosage from 29.3 +/- 21.8 mg to 11.1 +/- 7.4 11.1 mg (P less than .05). In the group with COPD there was also a significant decrease in steroid dosage--from 22.6 +/- 12.2 to 6.0 +/- 4.5 mg. These changes were not associated with a decline in spirometric values; nor was improvement secondary to improved theophylline levels, as demonstrated by a significant decrease in serum theophylline levels from 12.4 +/- 3.6 mg/dL baseline to 8.5 +/- 2.8 mg/dL (P less than .001) after maximal steroid tapering. We conclude that troleandomycin is effective in reducing the steroid dosage in patients with COPD or asthma. JF - Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians AU - Shivaram, U AU - Cash, M AD - Pulmonary Section, Veterans Administration Medical Center, Brooklyn, NY. Y1 - 1991 PY - 1991 DA - 1991 SP - 131 EP - 133 VL - 2 IS - 3 SN - 1048-9886, 1048-9886 KW - Adrenal Cortex Hormones KW - 0 KW - Theophylline KW - C137DTR5RG KW - Troleandomycin KW - C4DZ64560D KW - Methylprednisolone KW - X4W7ZR7023 KW - Index Medicus KW - Respiratory Function Tests KW - Methylprednisolone -- administration & dosage KW - Spirometry KW - Humans KW - Substance-Related Disorders KW - Aged KW - Middle Aged KW - Male KW - Female KW - Theophylline -- administration & dosage KW - Asthma -- drug therapy KW - Troleandomycin -- therapeutic use KW - Troleandomycin -- administration & dosage KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72705610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.atitle=Use+of+troleandomycin+as+a+steroid-sparing+agent+in+both+asthma+and+chronic+obstructive+pulmonary+disease.&rft.au=Shivaram%2C+U%3BCash%2C+M&rft.aulast=Shivaram&rft.aufirst=U&rft.date=1991-01-01&rft.volume=2&rft.issue=3&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.issn=10489886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-27 N1 - Date created - 1992-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alpha-fetoprotein alterations in alcoholics with liver disease. V.A. Cooperative Study Groups. AN - 72701364; 1725107 AB - Sera on 409 male alcoholics with liver injury were assayed for alpha-fetoprotein (AFP) as part of a VA co-operative study on the natural history and therapy of alcoholic liver disease. In 78% of the patients values below normal were observed and 42% had undetectable levels. Clinically the lowest AFP concentrations were observed in the more severely ill patients with the poorest 1 year survival. Furthermore, improvement in AFP was associated with improved survival. Correlation analysis showed a relationship of AFP to (1) visceral protein concentrations (i.e. albumin, transferrin, retinal binding protein); (2) variables related to hepatic fibrogenesis (i.e. Ito cell activity, quantitative estimates of fibrosis and Kupffer cell abnormalities); and (3) changes in immunoglobulin levels particularly IgG. These findings suggest that AFP is a good index of disease prognosis. JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Mendenhall, C L AU - Chedid, A AU - French, S W AU - Ray, M AU - Roselle, G A AU - Grossman, C J AU - Weesner, R E AU - Gartside, P S AD - Veterans Administration Medical Center, Cincinnati, OH. Y1 - 1991 PY - 1991 DA - 1991 SP - 527 EP - 534 VL - 26 IS - 5-6 SN - 0735-0414, 0735-0414 KW - alpha-Fetoproteins KW - 0 KW - Index Medicus KW - Liver -- pathology KW - Hepatic Encephalopathy -- diagnosis KW - Humans KW - Hepatic Encephalopathy -- blood KW - Middle Aged KW - Biopsy KW - Hepatic Encephalopathy -- pathology KW - Radioimmunoassay KW - Male KW - Liver Diseases, Alcoholic -- pathology KW - Alcoholism -- pathology KW - Alcoholism -- diagnosis KW - Liver Function Tests KW - alpha-Fetoproteins -- analysis KW - Liver Diseases, Alcoholic -- diagnosis KW - Liver Diseases, Alcoholic -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72701364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Alpha-fetoprotein+alterations+in+alcoholics+with+liver+disease.+V.A.+Cooperative+Study+Groups.&rft.au=Mendenhall%2C+C+L%3BChedid%2C+A%3BFrench%2C+S+W%3BRay%2C+M%3BRoselle%2C+G+A%3BGrossman%2C+C+J%3BWeesner%2C+R+E%3BGartside%2C+P+S&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1991-01-01&rft.volume=26&rft.issue=5-6&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-01 N1 - Date created - 1992-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium antagonists and the kidney: implications for renal protection. AN - 72699526; 1725007 AB - During the past decade, attention has focused on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal effects. Calcium antagonists do not affect the vasodilated isolated perfused kidney (IPK), but they do dramatically alter the response of this preparation to vasoconstrictor agents. Our recent studies using the isolated perfused hydronephrotic rat kidney model, which permits direct visualization of afferent and efferent arterioles, have demonstrated that the preferential augmentation of the glomerular filtration rate observed in the IPK is attributable to preferential vasodilation of preglomerular vessels. Although the clinical implications of such observations have not been fully delineated, the results of recent studies indicate that calcium antagonists exert salutary effects on renal function in patients with impaired renal hemodynamics. Such disorders include radiocontrast-induced nephrotoxicity and transplant-associated acute renal insufficiency. It is apparent, however, that the effects of calcium antagonists on renal blood flow commend their use in the management of essential hypertension. JF - Journal of cardiovascular pharmacology AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, Florida 33125. Y1 - 1991 PY - 1991 DA - 1991 SP - S64 EP - S70 VL - 18 Suppl 10 SN - 0160-2446, 0160-2446 KW - Calcium Channel Blockers KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Renal Circulation -- drug effects KW - Perfusion KW - Humans KW - In Vitro Techniques KW - Kidney Diseases -- drug therapy KW - Calcium Channel Blockers -- pharmacology KW - Kidney -- drug effects KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72699526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Calcium+antagonists+and+the+kidney%3A+implications+for+renal+protection.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=1991-01-01&rft.volume=18+Suppl+10&rft.issue=&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-29 N1 - Date created - 1992-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diltiazem and renal hemodynamics: implications for renal protection. AN - 72697705; 1725538 AB - During the past decade, attention has focused on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists (including diltiazem) do not affect the vasodilated isolated perfused kidney, but they do dramatically alter the response of this preparation to vasoconstrictor agents. Our recent studies using the isolated perfused hydronephrotic rat kidney model, which permits direct visualization of afferent and efferent arterioles, have demonstrated that the preferential augmentation of glomerular filtration rate induced by calcium antagonists in the isolated perfused kidney is attributable to preferential vasodilation of preglomerular vessels. Although the clinical implications of such observations have not been fully delineated, the results of recent studies indicate that calcium antagonists exert salutary effects on renal function in patients with impaired renal hemodynamics, such as radiocontrast-induced nephrotoxicity and transplant-associated acute renal insufficiency. JF - Journal of cardiovascular pharmacology AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1991 PY - 1991 DA - 1991 SP - S21 EP - S25 VL - 18 Suppl 9 SN - 0160-2446, 0160-2446 KW - Diltiazem KW - EE92BBP03H KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Dogs KW - Kidney Diseases -- prevention & control KW - Hemodynamics KW - Kidney Diseases -- drug therapy KW - Renal Circulation -- drug effects KW - Diltiazem -- pharmacology KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72697705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Diltiazem+and+renal+hemodynamics%3A+implications+for+renal+protection.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=1991-01-01&rft.volume=18+Suppl+9&rft.issue=&rft.spage=S21&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-19 N1 - Date created - 1992-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dexamethasone and glucagon cause synergistic increases of urea cycle enzyme activities in livers of normal but not adrenalectomized rats. AN - 72693780; 1806364 AB - Adrenalectomized and intact rats were given constant high-dose infusions of glucagon, 0.3 mg/kg per day for 7 days, with or without low-dose dexamethasone, 0.01 mg/kg daily, to test whether glucocorticoids potentiate glucagon induction of the 5 urea cycle enzymes as they do in cultured rat hepatocytes. Glucagon did not induce any of the urea cycle enzymes in adrenalectomized Sprague-Dawley rats and only induced argininosuccinate lyase (EC 4.3.2.1) in adrenalectomized inbred Wistar-Furth rats. Dexamethasone alone induced arginase in adrenalectomized and in intact Wistar-Furth rats and restored the other enzymes to normal levels in adrenalectomized rats. In intact Wistar-Furth rats, the combination of hormones gave synergistic increases of all 5 enzymes over the responses to each hormone alone, but in adrenalectomized rats the combination was only additive or less than additive compared with the sum of single hormone responses. The lack of synergism between the two hormones in adrenalectomized rats suggest that other factors play a role in glucagon induction of this cycle. JF - Enzyme AU - Snodgrass, P J AD - Veterans Administration Medical Center, Indianapolis, Ind. Y1 - 1991 PY - 1991 DA - 1991 SP - 30 EP - 38 VL - 45 IS - 1-2 SN - 0013-9432, 0013-9432 KW - Dexamethasone KW - 7S5I7G3JQL KW - Urea KW - 8W8T17847W KW - Glucagon KW - 9007-92-5 KW - Ornithine Carbamoyltransferase KW - EC 2.1.3.3 KW - Arginase KW - EC 3.5.3.1 KW - Argininosuccinate Lyase KW - EC 4.3.2.1 KW - Argininosuccinate Synthase KW - EC 6.3.4.5 KW - Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) KW - EC 6.3.5.5 KW - Index Medicus KW - Rats KW - Animals KW - Drug Interactions KW - Argininosuccinate Synthase -- analysis KW - Arginase -- analysis KW - Argininosuccinate Lyase -- analysis KW - Adrenal Glands -- physiology KW - Ornithine Carbamoyltransferase -- analysis KW - Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) -- analysis KW - Adrenalectomy KW - Male KW - Urea -- metabolism KW - Liver -- enzymology KW - Enzyme Induction -- drug effects KW - Dexamethasone -- pharmacology KW - Glucagon -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72693780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Enzyme&rft.atitle=Dexamethasone+and+glucagon+cause+synergistic+increases+of+urea+cycle+enzyme+activities+in+livers+of+normal+but+not+adrenalectomized+rats.&rft.au=Snodgrass%2C+P+J&rft.aulast=Snodgrass&rft.aufirst=P&rft.date=1991-01-01&rft.volume=45&rft.issue=1-2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Enzyme&rft.issn=00139432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-11 N1 - Date created - 1992-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of cocaine on thyroid functions. AN - 72535131; 1746504 AB - Results of routine thyroid function tests in heavy cocaine abusers at the time of treatment admission were not statistically different from normal values for our laboratory or from a similar group of other substance abuse patients in treatment. This suggests that heavy cocaine use per se does not affect thyroid function. Therefore, if the thyroid function tests are abnormal in a cocaine abuser, then a true thyroid dysfunction should be considered and completely evaluated. In addition, nonspecific alterations in thyroid function tests in nonthyroidal illnesses should be kept in mind. JF - The American journal of drug and alcohol abuse AU - Dhopesh, V P AU - Burke, W M AU - Maany, I AU - Ravi, N V AD - Inpatient Substance Abuse Treatment & Research Unit, Penn-VA Center for Studies on Addiction, Philadelphia Veterans Administration Medical Center 19104. Y1 - 1991 PY - 1991 DA - 1991 SP - 423 EP - 427 VL - 17 IS - 4 SN - 0095-2990, 0095-2990 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Thyroid Gland -- drug effects KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Substance-Related Disorders -- blood KW - Thyroid Function Tests KW - Cocaine -- pharmacokinetics KW - Substance-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72535131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Effect+of+cocaine+on+thyroid+functions.&rft.au=Dhopesh%2C+V+P%3BBurke%2C+W+M%3BMaany%2C+I%3BRavi%2C+N+V&rft.aulast=Dhopesh&rft.aufirst=V&rft.date=1991-01-01&rft.volume=17&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-14 N1 - Date created - 1992-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Malignant thymoma associated with peripheral T-cell lymphocytosis. AN - 72511747; 1961136 AB - Three cases of peripheral T-cell lymphocytosis associated with thymoma are described. Each patient had a malignant, predominantly lymphocytic thymoma with resolution of lymphocytosis upon treatment of the epithelial neoplasm. These findings suggest that lymphocytosis complicating thymoma is a paraneoplastic phenomenon and is not part of the neoplastic process. JF - Medical and pediatric oncology AU - Doll, D C AU - Landreneau, R J AU - List, A F AD - Department of Medicine, Veterans Administration Hospital, Columbia, MO 65212. Y1 - 1991 PY - 1991 DA - 1991 SP - 496 EP - 498 VL - 19 IS - 6 SN - 0098-1532, 0098-1532 KW - Antigens, CD KW - 0 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Antigens, CD -- analysis KW - Combined Modality Therapy KW - Humans KW - Vincristine -- administration & dosage KW - Aged KW - Doxorubicin -- administration & dosage KW - Leukocyte Count KW - Cisplatin -- administration & dosage KW - Adult KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Prednisone -- administration & dosage KW - Male KW - T-Lymphocytes KW - Thymoma -- pathology KW - Thymus Neoplasms -- complications KW - Lymphocytosis -- etiology KW - Thymoma -- therapy KW - Thymus Neoplasms -- immunology KW - Thymoma -- complications KW - Thymoma -- immunology KW - Thymus Neoplasms -- pathology KW - Thymus Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72511747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+and+pediatric+oncology&rft.atitle=Malignant+thymoma+associated+with+peripheral+T-cell+lymphocytosis.&rft.au=Doll%2C+D+C%3BLandreneau%2C+R+J%3BList%2C+A+F&rft.aulast=Doll&rft.aufirst=D&rft.date=1991-01-01&rft.volume=19&rft.issue=6&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Medical+and+pediatric+oncology&rft.issn=00981532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-09 N1 - Date created - 1992-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An appraisal of chemical aversion (emetic therapy) approaches to alcoholism treatment. AN - 72505964; 1741730 AB - More than 35,000 alcoholics have received chemical aversion (emetic therapy) in at least 75 settings worldwide since the 1930s. This consummatory aversion (CA) treatment, which pairs ethanol ingestion with emetically induced nausea, incorporates the highly efficient variety of learning known as taste aversion (TA) conditioning. The CA literature indicates that emetic therapy should induce conditioned alcohol aversions in many alcoholics. Such aversions have been widely reported by clinicians and have been confirmed by recent psychophysiological evidence. Long standing evidence of treatment effectiveness is found in the results of private hospitals which have consistently produced 1-yr abstinence rates approximating 60%. Diminished alcohol craving is a frequently reported benefit. Few experimental evaluations have been completed, as is generally the case for all alcoholism treatments, but those which used methodologically sound temporal parameters during conditioning have supported the clinical efficacy of emetic therapy. The clear need for more definitive research notwithstanding, there are compelling indications that emetic therapy is a useful component of multimodal treatment within certain alcoholic populations. However, its availability is severely limited. Many alcoholics could probably benefit from expanded treatment availability. The time is ripe for a reevaluation of resistances to the clinical use of emetic therapy alcoholism treatment. JF - Behaviour research and therapy AU - Elkins, R L AD - Psychology Research, Veterans Administration Medical Center, Augusta, GA 30910. Y1 - 1991 PY - 1991 DA - 1991 SP - 387 EP - 413 VL - 29 IS - 5 SN - 0005-7967, 0005-7967 KW - Emetics KW - 0 KW - Index Medicus KW - Humans KW - Conditioning, Classical -- drug effects KW - Follow-Up Studies KW - Emetics -- therapeutic use KW - Alcoholism -- rehabilitation KW - Aversive Therapy -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+research+and+therapy&rft.atitle=An+appraisal+of+chemical+aversion+%28emetic+therapy%29+approaches+to+alcoholism+treatment.&rft.au=Elkins%2C+R+L&rft.aulast=Elkins&rft.aufirst=R&rft.date=1991-01-01&rft.volume=29&rft.issue=5&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Behaviour+research+and+therapy&rft.issn=00057967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-09 N1 - Date created - 1992-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Behav Res Ther. 1991;29(5):415-9; discussion 421-8 [1741731] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased susceptibility of the portal hypertensive gastric mucosa to damage. AN - 72457062; 1940192 AB - Portal hypertensive gastropathy has recently been recognized as a unique entity distinct from other gastropathies involving the normotensive gastric mucosa. To delineate the pathophysiology of this disorder, we developed a rat model of portal hypertension using two-staged portal vein ligation. In this model, features of the portal hypertensive mucosa include increased luminal hydrogen ion loss, reduced electronegativity of potential difference, and increased submucosal edema. Ultrastructurally, the portal hypertensive gastric mucosa has marked endothelial hypertrophy of capillaries resulting in prominent compromise of microvascular lumina. Combined with the submucosal edema, the microvasculopathy results in reduced oxygenation of the surface gastric mucosa. This is associated with diminished prostaglandin production, which impairs gastric mucosal protection in portal hypertension. These observations are strengthened by experiments that demonstrated significantly increased gastric mucosal damage by alcohol, bile acids, aspirin, and shock/reperfusion in portal hypertensive rats compared to normotensive sham-operated controls. Many of our experimental findings have been confirmed clinically; however, much more research in this area is clearly needed. JF - Journal of clinical gastroenterology AU - Sarfeh, I J AU - Tarnawski, A AD - Department of Surgery, Long Beach Veterans Administration Medical Center, CA. Y1 - 1991 PY - 1991 DA - 1991 SP - S18 EP - S21 VL - 13 Suppl 1 SN - 0192-0790, 0192-0790 KW - Bile Acids and Salts KW - 0 KW - Prostaglandins KW - Ethanol KW - 3K9958V90M KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Rats KW - Animals KW - Reperfusion Injury -- physiopathology KW - Aspirin -- toxicity KW - Ethanol -- toxicity KW - Disease Models, Animal KW - Bile Acids and Salts -- toxicity KW - Prostaglandins -- metabolism KW - Gastric Mucosa -- physiopathology KW - Gastric Mucosa -- pathology KW - Hypertension, Portal -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72457062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Increased+susceptibility+of+the+portal+hypertensive+gastric+mucosa+to+damage.&rft.au=Sarfeh%2C+I+J%3BTarnawski%2C+A&rft.aulast=Sarfeh&rft.aufirst=I&rft.date=1991-01-01&rft.volume=13+Suppl+1&rft.issue=&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-29 N1 - Date created - 1991-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Discrepancies between patient report, clinical assessment, and urine analysis in psychiatric patients during inpatient admission. AN - 72154412; 1924662 AB - Self-report and clinical assessment of substance use were compared with urine analysis results in 56 male patients consecutively admitted for inpatient psychiatric treatment. All subjects received DSM-III-R Axis I diagnosis and were classified into diagnostic groups. Urine samples were tested for cocaine, marijuana, opiates, phencyclidine (PCP), amphetamines, and barbiturates. Thirty-five of the 56 patients (62%) produced urine samples that were positive for at least 1 substance of abuse. Of this group, 15 patients (27% of total sample) denied substance use during the week prior to admission. In addition, the admitting physician did not identify intoxication in 23 of the 35 patients (66%) with positive urines. The admitting physician's assessment matched the patient's answers regarding recent substance use in 79 percent of the patients. This association was especially apparent with the 26 patients who denied recent substance use, all but one of whom received a drug-negative assessment from the admitting physician. JF - Psychopharmacology bulletin AU - Wilkins, J N AU - Shaner, A L AU - Patterson, M AU - Setoda, D AU - Gorelick, D AD - West Los Angeles Veterans Administration Medical Center, Brentwood Division, CA 90073. Y1 - 1991 PY - 1991 DA - 1991 SP - 149 EP - 154 VL - 27 IS - 2 SN - 0048-5764, 0048-5764 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Male KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- urine KW - Substance-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72154412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology+bulletin&rft.atitle=Discrepancies+between+patient+report%2C+clinical+assessment%2C+and+urine+analysis+in+psychiatric+patients+during+inpatient+admission.&rft.au=Wilkins%2C+J+N%3BShaner%2C+A+L%3BPatterson%2C+M%3BSetoda%2C+D%3BGorelick%2C+D&rft.aulast=Wilkins&rft.aufirst=J&rft.date=1991-01-01&rft.volume=27&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology+bulletin&rft.issn=00485764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydrocarbons and renal failure. AN - 72151208; 1922601 JF - Nephron AU - Roy, A T AU - Brautbar, N AU - Lee, D B AD - Veterans Administration Medical Center, Sepulveda, Calif. Y1 - 1991 PY - 1991 DA - 1991 SP - 385 EP - 392 VL - 58 IS - 4 SN - 1660-8151, 1660-8151 KW - Hydrocarbons KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Kidney Failure, Chronic -- chemically induced KW - Occupational Diseases -- chemically induced KW - Hydrocarbons -- pharmacokinetics KW - Hydrocarbons -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72151208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Hydrocarbons+and+renal+failure.&rft.au=Roy%2C+A+T%3BBrautbar%2C+N%3BLee%2C+D+B&rft.aulast=Roy&rft.aufirst=A&rft.date=1991-01-01&rft.volume=58&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-18 N1 - Date created - 1991-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nephron. 1992;61(2):243 [1630558] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seroprevalence of HTLV-I/II and HIV-1 infection among male intravenous drug abusers in Chicago. AN - 72096994; 1895212 AB - We surveyed for serologic evidence of either HIV-1 or HTLV-I/II infection in 387 male veterans who entered into an inpatient drug treatment center. Serum was obtained after receiving written informed consent. Serum specimens were tested by enzyme-linked immunosorbent assay for antibody to HIV-1 and for antibody to HTLV-I/II; sera that were repeatedly reactive were then tested by Western blot (HIV-1/HTLV-I/II) and radioimmunoprecipitation assay (HTLV-I/II). Sixty-five of 387 (16.79%) patients were tested and confirmed as positive for HTLV-I/II only antibodies and 30 of the 387 (7.75%) were positive for HIV-1 only antibodies. An additional nine patients (2.32%) were seropositive for antibodies to both viruses. A statistically significant difference in the CD4/CD8 lymphocyte ratio was associated with HIV-1 seropositivity. HTLV-I/II seropositivity was strongly associated with black race, age, and duration of i.v. drug use, but not with sexual intercourse as determined by lifetime history of number of sexual partners, incidence of sexually transmitted diseases, type of drug used, or needle-sharing practices. JF - Journal of acquired immune deficiency syndromes AU - Lentino, J R AU - Pachucki, C T AU - Schaaff, D M AU - Schaefer, M R AU - Holzer, T J AU - Heynen, C AU - Dawson, G AU - Dorus, W AD - Section of Infectious Diseases Medical Service, Edward Hines, Jr. Veterans Administration Hospital, Hines, Illinois. Y1 - 1991 PY - 1991 DA - 1991 SP - 901 EP - 909 VL - 4 IS - 9 SN - 0894-9255, 0894-9255 KW - HIV Antibodies KW - 0 KW - HTLV-I Antibodies KW - HTLV-II Antibodies KW - Index Medicus KW - AIDS/HIV KW - HTLV-II Antibodies -- analysis KW - HTLV-I Antibodies -- analysis KW - Demography KW - Blotting, Western KW - Humans KW - Adult KW - HIV Antibodies -- analysis KW - Chicago KW - Male KW - HTLV-I Infections -- epidemiology KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - HTLV-II Infections -- epidemiology KW - Acquired Immunodeficiency Syndrome -- transmission KW - Substance-Related Disorders KW - HTLV-I Infections -- transmission KW - HIV-1 KW - HTLV-II Infections -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72096994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes&rft.atitle=Seroprevalence+of+HTLV-I%2FII+and+HIV-1+infection+among+male+intravenous+drug+abusers+in+Chicago.&rft.au=Lentino%2C+J+R%3BPachucki%2C+C+T%3BSchaaff%2C+D+M%3BSchaefer%2C+M+R%3BHolzer%2C+T+J%3BHeynen%2C+C%3BDawson%2C+G%3BDorus%2C+W&rft.aulast=Lentino&rft.aufirst=J&rft.date=1991-01-01&rft.volume=4&rft.issue=9&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes&rft.issn=08949255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-18 N1 - Date created - 1991-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of high parathyroid hormone levels on the development of aluminum-induced osteomalacia in the rat. AN - 72072513; 1883967 AB - A relative deficiency of parathyroid hormone (PTH) is generally observed in dialysis patients with aluminum-associated osteomalacia or aplastic bone disease. It has been suggested that high PTH levels may protect against the development of aluminum-associated bone disease. Through the use of a previously established model of aluminum-induced osteomalacia in the rat, the protective effect of PTH was evaluated. Aluminum was administered intraperitoneally at doses of 0, 5, 10, and 20 mg during a 2-day period, and rats were sacrificed 5 and 12 days after aluminum administration. PTH (bovine 1-34) was administered via a subcutaneously implanted Alzet pump at 2 U/h starting 4 days before aluminum administration and continuing until sacrifice. As the aluminum dose was increased to 20 mg, the osteoblast surface and the bone formation rate decreased. PTH supplementation increased the osteoblast surface at all doses of aluminum and increased the bone formation rate at 0 and 5 mg of aluminum. However, even with PTH supplementation, osteoblast surface decreased as the aluminum dose increased. In the absence of PTH supplementation, osteoblast surface was markedly reduced when the serum aluminum concentration was greater than 400 micrograms/liter or stainable trabecular aluminum surface exceeded 15%. When the stainable trabecular aluminum surface was greater than 12%, the bone formation rate was zero even during supplemental PTH administration. A significant correlation was observed between serum aluminum and stainable trabecular aluminum surface (r = 0.80 at 5 days and r = 0.86 at 12 days; P less than 0.001). However, after PTH administration, less stainable trabecular aluminum was present for the same serum aluminum concentration. Both with and without PTH, the slope of the correlation between serum aluminum and stainable trabecular aluminum surface was steeper at 5 days after aluminum administration than at 12 days. In conclusion, for an equivalent aluminum exposure, high PTH levels protected against the development of low turnover aluminum bone disease in the rat. JF - Journal of the American Society of Nephrology : JASN AU - Felsenfeld, A J AU - Machado, L AU - Rodriguez, M AD - Department of Medicine, Wadsworth Veterans Administration, Los Angeles, CA 90073. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 970 EP - 979 VL - 1 IS - 7 SN - 1046-6673, 1046-6673 KW - Parathyroid Hormone KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Kidney Failure, Chronic -- pathology KW - Dose-Response Relationship, Drug KW - Bone and Bones -- pathology KW - Kidney Failure, Chronic -- physiopathology KW - Male KW - Osteogenesis KW - Osteoblasts -- pathology KW - Parathyroid Hormone -- pharmacology KW - Osteomalacia -- pathology KW - Osteomalacia -- blood KW - Aluminum -- blood KW - Parathyroid Hormone -- blood KW - Osteomalacia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72072513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=The+effect+of+high+parathyroid+hormone+levels+on+the+development+of+aluminum-induced+osteomalacia+in+the+rat.&rft.au=Felsenfeld%2C+A+J%3BMachado%2C+L%3BRodriguez%2C+M&rft.aulast=Felsenfeld&rft.aufirst=A&rft.date=1991-01-01&rft.volume=1&rft.issue=7&rft.spage=970&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-08 N1 - Date created - 1991-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Beginning Development of a Model for Joint Research between a Hospital Social Work Department and a School of Social Work AN - 61654904; 199101908 AB - A description of the work of a hospital social work department & a school of social work in Miss to develop a model to encourage a joint research endeavor. Identified are guidelines used & some problems encountered in initiating the model, which encourages practice-based research & publication. In general, the efforts of agencies & schools of social work to encourage research & professional writing among their staff & faculty have brought uneven results. Some characteristics of the model generalizable to other organizational needs are delineated. 1 Figure, 20 References. Adapted from the source document. JF - Social Work in Health Care AU - Pruet, Rebecca A AU - Shea, Timothy P AU - Zimmerman, Jerome AU - Parish, Geraldine AD - Social Work Service Veterans Administration Medical Center, Jackson MS 39216 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 63 EP - 75 VL - 15 IS - 3 SN - 0098-1389, 0098-1389 KW - joint research, hospital social work department-school of social work, Mississippi KW - Cooperation KW - Social Work Education KW - Mississippi KW - Research KW - Social Work KW - Hospitals KW - Models KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61654904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=The+Beginning+Development+of+a+Model+for+Joint+Research+between+a+Hospital+Social+Work+Department+and+a+School+of+Social+Work&rft.au=Pruet%2C+Rebecca+A%3BShea%2C+Timothy+P%3BZimmerman%2C+Jerome%3BParish%2C+Geraldine&rft.aulast=Pruet&rft.aufirst=Rebecca&rft.date=1991-01-01&rft.volume=15&rft.issue=3&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work Education; Cooperation; Models; Mississippi; Social Work; Hospitals; Research ER - TY - JOUR T1 - Retirement: What Happens to Husband-Wife Relationships? AN - 61308020; 92Y6798 AB - To study the impact of the transition to retirement in the first year on male retirees & their spouses, focused interviews were conducted with each spouse in 92 white middle-class couples in Boston, Mass, a sample drawn from a larger Veterans Administration study ("The Normative Aging Study," Maddox, G. L., et al [Eds], Encyclopedia of Aging, New York: Springer, 1987). Changes in household tasks, companionship activities, personal leisure activities, satisfaction, & marital adjustment & problems were studied. Findings showed that, overall, the majority of spouses were satisfied with retirement & did not consider it a crisis in their lives, but a continuation in terms of marital quality; few differences in marital complaints were revealed between couples in which the husband was completely retired & those in which he continued to work part-time. In Discussion: Retirement: What Happens to Husband-Wife Relationships?, James Mann (Boston U School of Medicine, Mass) raises several questions about the study, including the lack of information about postretirement sexuality, whether retirement was voluntary or involuntary, the importance of denial, & inner psychological changes. 14 References. M. Malas JF - Journal of Geriatric Psychiatry AU - Vinick, Barbara H AU - Ekerdt, David J AD - Veterans Administration Outpatient Clinic, 251 Causeway St Boston MA 02114 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 23 EP - 40 VL - 24 IS - 1 SN - 0022-1414, 0022-1414 KW - transition to retirement, male retirees/their spouses KW - interviews KW - white middle-class couples KW - article/discussion KW - Whites KW - Middle Class KW - Males KW - Retirement KW - Spouses KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61308020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geriatric+Psychiatry&rft.atitle=Retirement%3A+What+Happens+to+Husband-Wife+Relationships%3F&rft.au=Vinick%2C+Barbara+H%3BEkerdt%2C+David+J&rft.aulast=Vinick&rft.aufirst=Barbara&rft.date=1991-01-01&rft.volume=24&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geriatric+Psychiatry&rft.issn=00221414&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - SuppNotes - Discussion, 41-46. N1 - Last updated - 2016-09-28 N1 - CODEN - JGPSBZ N1 - SubjectsTermNotLitGenreText - Retirement; Males; Spouses; Whites; Middle Class ER - TY - JOUR T1 - Factors Influencing the Decision to Rehabilitate: An Initial Comparison of Rehabilitation Candidates AN - 61272085; 92Y8982 AB - Consecutive admissions (N = 3,170) to acute medical neurologic, & surgical wards of a US Veterans Administration hospital were classified into 5 clinical subgroups based on diagnostic, prognostic, & functional criteria: independent, terminal, medical, dementia, & rehabilitation candidate. Medical record data from admission, discharge, & 9-month follow-up revealed unique patterns of survival, residence, & use of health care services among the subgroups. In comparison to a group who did not receive rehabilitation, rehabilitation participants had lower mortality, spent less time in skilled care, & were less frequently hospitalized. Implications for rehabilitation interventions are presented. 4 Tables, 25 References. Adapted from the source document. JF - Social Science and Medicine AU - Evans, Ron L AU - Haselkorn, Jodie K AU - Bishop, Duane S AU - Hendricks, Robert D AD - Veterans Administration Medical Center, 1660 South Columbian Way Seattle WA 98108 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 801 EP - 806 VL - 33 IS - 7 SN - 0277-9536, 0277-9536 KW - rehabilitation decisions, diagnostic/prognostic/functional criteria KW - patient records KW - Veterans Administration hospital, US KW - Diagnosis KW - Rehabilitation KW - United States of America KW - Decision Making KW - Hospitals KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61272085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=Factors+Influencing+the+Decision+to+Rehabilitate%3A+An+Initial+Comparison+of+Rehabilitation+Candidates&rft.au=Evans%2C+Ron+L%3BHaselkorn%2C+Jodie+K%3BBishop%2C+Duane+S%3BHendricks%2C+Robert+D&rft.aulast=Evans&rft.aufirst=Ron&rft.date=1991-01-01&rft.volume=33&rft.issue=7&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Rehabilitation; Decision Making; Diagnosis; Hospitals; United States of America ER - TY - JOUR T1 - Group Therapy with Schizophrenic Patients: A Short-Term, Homogeneous Approach AN - 1761715305; 199101232 AB - Described is a short-term, homogenous model for treating schizophrenic patients in discussion-oriented therapy groups. Typically, patients attend 9 sessions in the open inpatient groups & 12 sessions in the closed outpatient groups. The goals of such a cotherapy approach are to help patients cope with psychotic experiences & improve their interpersonal relationships. Group discussions focus on hallucinations, delusions, loose associations, & maladaptive relationships, & anxiety-producing topics are avoided. The format is interaction-oriented & emphasizes the here & now. Empirical evidence from several clinical studies supports the value of this approach when used in conjunction with antipsychotic medications & long-term follow-up. 24 References. Adapted from the source document. JF - International Journal of Group Psychotherapy AU - Kanas, Nick AD - San Francisco Veterans Administration Medical Center, 4150 Clement St #116A CA 94121 Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 33 EP - 48 VL - 41 IS - 1 SN - 0020-7284, 0020-7284 KW - discussion-oriented group therapy model, schizophrenic patients KW - clinical studies KW - Schizophrenia KW - Outpatients KW - Group Therapy KW - Treatment Methods KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761715305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Group+Psychotherapy&rft.atitle=Group+Therapy+with+Schizophrenic+Patients%3A+A+Short-Term%2C+Homogeneous+Approach&rft.au=Kanas%2C+Nick&rft.aulast=Kanas&rft.aufirst=Nick&rft.date=1991-01-01&rft.volume=41&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Group+Psychotherapy&rft.issn=00207284&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Group Therapy; Outpatients; Schizophrenia; Treatment Methods ER - TY - JOUR T1 - Sequential Analyses of Adolescent, Mother, and Father Behaviors in Distressed and Nondistressed Families AN - 1761713620; 199201287 AB - Sequential relations in parent-child interactions were examined by observation & assessment of 4 intact clinic (C) families & 4 comparable nonclinic (NC) families under 2 experimental conditions -- discussing a problem & planning an activity together. C families manifested more negative & less problem-solving behavior. During the planning activity, C mothers responded to their adolescents' negative behavior more often with negative behavior & less often with problem solving than their NC counrterparts. C adolescents as compared to NC adolescents responded to their mothers' negative behavior more often with negative behavior & less often with problem solving during both the problem-solving & planning tasks. These patterns were not observed with fathers. During planning activities, C adolescents responded to both mothers' & fathers' problem solving with more negative & less problem-solving behavior than did NC adolescents. 1 Table, 2 Figures, 28 References. Adapted from the source document. JF - Child & Family Behavior Therapy AU - Krinsley, Karen E AU - Bry, Brenna H AD - National Center PTSD Boston Veterans Administration Medical Center, 150 South Huntington Ave MA 02130 Y1 - 1991///0, PY - 1991 DA - 0, 1991 SP - 45 EP - 62 VL - 13 IS - 4 SN - 0731-7107, 0731-7107 KW - sequential relations, parent-child interactions, intact clinic vs nonclinic families KW - experiment, observation KW - Family Relations KW - Activities KW - Parent Child Relations KW - Behavior Problems KW - Adolescents KW - Problem Solving KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761713620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+%26+Family+Behavior+Therapy&rft.atitle=Sequential+Analyses+of+Adolescent%2C+Mother%2C+and+Father+Behaviors+in+Distressed+and+Nondistressed+Families&rft.au=Krinsley%2C+Karen+E%3BBry%2C+Brenna+H&rft.aulast=Krinsley&rft.aufirst=Karen&rft.date=1991-01-01&rft.volume=13&rft.issue=4&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Child+%26+Family+Behavior+Therapy&rft.issn=07317107&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Parent Child Relations; Problem Solving; Activities; Adolescents; Family Relations; Behavior Problems ER - TY - JOUR T1 - Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. AN - 80309820; 1707735 AB - Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin and a specific marker for serotonergic neurons. These neurons are affected in Alzheimer's disease (AD) in several ways: serotonin is decreased in axon terminals, serotonin neurons accumulate neurofibrillary protein, and these neurons are lost in AD brains. One subcellular mechanism which may underlie degeneration of neurons in AD is decreased axonal transport with accumulation of enzymes and their potentially toxic metabolites in the cell body. To determine whether there is a defect in axonal transport in serotonin neurons in AD we measured TPH activity, serotonin and its oxidative metabolite 5-hydroxyindoleacetic acid (5-HIAA) in dorsal raphe cell bodies from Alzheimer and control cases. TPH activity is increased 4.7-fold in raphe neuron cell bodies in Alzheimer brains. Serotonin and 5-HIAA are increased by 4.0- and 2.0-fold, respectively in Alzheimer compared to control raphe cell bodies. In contrast, in synaptic terminals of the amygdala 5-HT and 5-HIAA were decreased by 41% and 50%, respectively in the same AD cases. We propose that the accumulation of TPH and its products in the raphe perikarya in AD results from a diminished transport of TPH to axon terminals. The accumulation of oxidative metabolites of serotonin may contribute to the degeneration of serotonergic neurons in AD. JF - Brain research AU - Burke, W J AU - Park, D H AU - Chung, H D AU - Marshall, G L AU - Haring, J H AU - Joh, T H AD - Department of Neurology, Veterans Administration Medical Center, St. Louis, MO. Y1 - 1990/12/24/ PY - 1990 DA - 1990 Dec 24 SP - 83 EP - 87 VL - 537 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Serotonin KW - 333DO1RDJY KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Tryptophan Hydroxylase KW - EC 1.14.16.4 KW - Index Medicus KW - Raphe Nuclei -- enzymology KW - Axons -- enzymology KW - Amygdala -- enzymology KW - Aged, 80 and over KW - Hydroxyindoleacetic Acid -- metabolism KW - Humans KW - Aged KW - Middle Aged KW - Serotonin -- metabolism KW - Male KW - Tryptophan Hydroxylase -- metabolism KW - Alzheimer Disease -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80309820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Evidence+for+decreased+transport+of+tryptophan+hydroxylase+in+Alzheimer%27s+disease.&rft.au=Burke%2C+W+J%3BPark%2C+D+H%3BChung%2C+H+D%3BMarshall%2C+G+L%3BHaring%2C+J+H%3BJoh%2C+T+H&rft.aulast=Burke&rft.aufirst=W&rft.date=1990-12-24&rft.volume=537&rft.issue=1-2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-23 N1 - Date created - 1991-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. AN - 80144502; 2250002 AB - The thyrotropin (TSH) receptor belongs to a family of guanine nucleotide protein-coupled receptors with seven transmembrane-spanning regions joined regulatory together by extracellular and intracellular loops. The cytoplasmic domain comprises three cytoplasmic loops and a cytoplasmic tail that are likely to be important in coupling of the receptor to the guanine nucleotide proteins. To address the question of which portions of the cytoplasmic domain of the TSH receptor are important in this process, we have altered groups of amino acids in the region of the TSH receptor by site-directed mutagenesis. Because of the low affinity of TSH binding to the TSH receptor mutated in the amino terminus of the second cytoplasmic loop and the amino terminus of the cytoplasmic tail, definitive conclusions cannot be made regarding the roles of these regions in signal transduction. However, our data indicate that the first cytoplasmic loop (residues 441-450), the carboxyl-terminal region of the second cytoplasmic loop (residues 528-537), and the carboxyl-terminal (but not the amino-terminal) region of the third cytoplasmic loop (residues 617-625) are important in the ability of the TSH receptor to mediate an increase in intracellular cAMP production. Furthermore, two-thirds of the carboxyl-terminal end of the cytoplasmic tail (residues 709-764; corresponding to the region not conserved between the TSH and lutropin/chorionic gonadotropin receptors) can be removed without functional impairment of the TSH receptor. JF - The Journal of biological chemistry AU - Chazenbalk, G D AU - Nagayama, Y AU - Russo, D AU - Wadsworth, H L AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1990/12/05/ PY - 1990 DA - 1990 Dec 05 SP - 20970 EP - 20975 VL - 265 IS - 34 SN - 0021-9258, 0021-9258 KW - Oligonucleotide Probes KW - 0 KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - Index Medicus KW - Base Sequence KW - Models, Molecular KW - Cytoplasm -- metabolism KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cell Membrane -- metabolism KW - Thyrotropin -- metabolism KW - Protein Conformation KW - Mutagenesis, Site-Directed KW - Receptors, Thyrotropin -- metabolism KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80144502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Functional+analysis+of+the+cytoplasmic+domains+of+the+human+thyrotropin+receptor+by+site-directed+mutagenesis.&rft.au=Chazenbalk%2C+G+D%3BNagayama%2C+Y%3BRusso%2C+D%3BWadsworth%2C+H+L%3BRapoport%2C+B&rft.aulast=Chazenbalk&rft.aufirst=G&rft.date=1990-12-05&rft.volume=265&rft.issue=34&rft.spage=20970&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Feeding the Hispanic hospital patient: cultural considerations. AN - 85237316; pmid-2246448 AB - As service-oriented professionals in a multicultural society, dietitians must be aware of cultural influences on food consumption patterns, population demographics, and health care usage by ethnic groups. The United States has one of the largest Hispanic populations in the world. The major health problems in the Hispanic population are cardiovascular disease, diabetes mellitus, and obesity. The use of health care services by Hispanic subgroups is dependent upon their residence in a rural or an urban area. This article summarizes national trends in food consumption, health care usage, prevalent health problems, and eating habits of Mexicans and Puerto Ricans, the most populous of the Hispanic subgroups. We provide diet modifications for energy-, fat- and sodium-restricted diets, which are part of the treatment for problems prevalent in this ethnic population. Dietitians must consider cultural and demographic influences to help Hispanic hospital patients modify their diet in ways that are both healthful and culturally acceptable. JF - Journal of the American Dietetic Association AU - Samolsky, S AU - Dunker, K AU - Hynak-Hankinson, M T AD - Dietetic Service, Veterans Administration Medical Center, East Orange, New Jersey 07019. PY - 1990 SP - 1707 EP - 1710 VL - 90 IS - 12 SN - 0002-8223, 0002-8223 KW - Mexico KW - Puerto Rico KW - Rural Population KW - Human KW - Health Status KW - Support, U.S. Gov't, Non-P.H.S. KW - Food Habits KW - Dietary Fats KW - Health Promotion KW - Eating KW - Hispanic Americans KW - Diet KW - Food Service, Hospital UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85237316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=Feeding+the+Hispanic+hospital+patient%3A+cultural+considerations.&rft.au=Samolsky%2C+S%3BDunker%2C+K%3BHynak-Hankinson%2C+M+T&rft.aulast=Samolsky&rft.aufirst=S&rft.date=1990-12-01&rft.volume=90&rft.issue=12&rft.spage=1707&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=00028223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Endoscopic management of early supraglottic cancer. AN - 85176940; pmid-2244727 AB - An initial endoscopic surgical approach to early supraglottic cancer provides the surgeon with the ability to accurately stage these lesions, avoiding possible undertreatment while allowing for a valuable treatment option for those supraglottic cancers with histologically incontrovertibly superficial disease. Early invasion of the preepiglottic and paraglottic spaces can be determined accurately without altering or delaying any treatment option (open surgical excision, radiotherapy, or chemotherapy). The tendency of supraglottic cancers to transgress the natural foramina of the epiglottis is well established, and the concern about this depth of invasion is reflected by the 1977 revised staging criteria, which required assessment of the preepiglottic space (PES). Along with the microscope and the carbon dioxide laser, the adjustable supraglottiscope facilitates the determination of PES invasion and facilitates en bloc excision of superficial supraglottic cancers. The resulting morbidity typically is no different from that with routine direct endoscopy and biopsy. JF - The Annals of Otology, Rhinology, and Laryngology AU - Zeitels, S M AU - Vaughan, C W AU - Domanowski, G F AD - Otolaryngology Section, Boston Veterans Administration Medical Center, Massachusetts. PY - 1990 SP - 951 EP - 956 VL - 99 IS - 12 SN - 0003-4894, 0003-4894 KW - Neoplasm Invasiveness KW - Glottis KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Follow-Up Studies KW - Laryngeal Neoplasms KW - Esophagoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85176940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Endoscopic+management+of+early+supraglottic+cancer.&rft.au=Zeitels%2C+S+M%3BVaughan%2C+C+W%3BDomanowski%2C+G+F&rft.aulast=Zeitels&rft.aufirst=S&rft.date=1990-12-01&rft.volume=99&rft.issue=12&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tetraethylammonium transport by OK cells. AN - 80389949; 2103849 AB - Mechanisms exist in renal proximal tubules for the mediated transepithelial secretion or reabsorption of endogenous and exogenous organic cations. In the studies presented here, the uptake of the organic cation tetraethylammonium (TEA) into confluent monolayers of opossum kidney cells was evaluated to determine if these cells might serve as an in vitro model of this transport pathway. 3H-TEA entered opossum kidney cells in a time-dependent manner. Uptake at early time points was saturable with an apparent Km of 59.1 +/- 11.2 microM and a Vmax of 1,292 +/- 210 fmol/micrograms of DNA. TEA uptake was inhibited in a dose-dependent manner by several other organic cations including amiloride, cimetidine, verapamil, procainamide, quinidine and N1-methylnicotinamide. With 1 mM concentrations of these compounds, uptake was virtually eliminated. However, another organic cation, N'-methylnicotinamide caused only minimal inhibition. TEA uptake was significantly reduced by sodium azide, suggesting dependence on oxidative phosphorylation. An alkaline medium pH enhanced TEA uptake, but, at the same pH, uptake was similar in the presence or absence of bicarbonate. When cellular pH was altered by ammonium chloride addition or removal, TEA uptake was not affected. Thus, organic cation/proton exchange, as has been demonstrated previously in apical membrane vesicles prepared from proximal tubules, is evidently not responsible for TEA uptake. Similarly, uptake does not appear to result from organic cation/organic cation exchange. These results indicate that the plasma membrane of opossum kidney cells contains a transport system(s) for the mediated uptake of organic cations and that these cells may be a useful mode for further study of renal epithelial transport of these solutes. JF - Journal of the American Society of Nephrology : JASN AU - McKinney, T D AU - Scheller, M B AU - Hosford, M AU - McAteer, J A AD - Medical Service, Veterans Administration Medical Center, Indianapolis, IN. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 902 EP - 909 VL - 1 IS - 6 SN - 1046-6673, 1046-6673 KW - Antimetabolites KW - 0 KW - Azides KW - Bicarbonates KW - Cations KW - Culture Media KW - Tetraethylammonium Compounds KW - Tetraethylammonium KW - 66-40-0 KW - Sodium Azide KW - 968JJ8C9DV KW - Index Medicus KW - Antimetabolites -- pharmacology KW - Animals KW - Bicarbonates -- pharmacology KW - Azides -- pharmacology KW - Time Factors KW - Cations -- pharmacology KW - Cell Line KW - Kidney -- metabolism KW - Tetraethylammonium Compounds -- pharmacokinetics KW - Kidney -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80389949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Tetraethylammonium+transport+by+OK+cells.&rft.au=McKinney%2C+T+D%3BScheller%2C+M+B%3BHosford%2C+M%3BMcAteer%2C+J+A&rft.aulast=McKinney&rft.aufirst=T&rft.date=1990-12-01&rft.volume=1&rft.issue=6&rft.spage=902&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-17 N1 - Date created - 1991-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Perspectives on the pathophysiology of fetal alcohol syndrome. AN - 80322840; 2088115 AB - Fetal alcohol syndrome (FAS) is a major known cause of fetal malformations and mental retardation. Prevention/intervention of FAS can only be achieved with identification of the mechanisms by which alcohol induces birth defects. The purpose of this paper is to discuss the data on possible mechanisms of FAS, and to give a number of suggestions for future research areas. JF - Alcoholism, clinical and experimental research AU - Randall, C L AU - Ekblad, U AU - Anton, R F AD - Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 807 EP - 812 VL - 14 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Animals KW - Ethanol -- pharmacokinetics KW - Acetaldehyde -- pharmacokinetics KW - Humans KW - Fetal Growth Retardation -- physiopathology KW - Female KW - Pregnancy KW - Fetal Alcohol Spectrum Disorders -- physiopathology KW - Maternal-Fetal Exchange -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80322840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Perspectives+on+the+pathophysiology+of+fetal+alcohol+syndrome.&rft.au=Randall%2C+C+L%3BEkblad%2C+U%3BAnton%2C+R+F&rft.aulast=Randall&rft.aufirst=C&rft.date=1990-12-01&rft.volume=14&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-20 N1 - Date created - 1991-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethanol induced morphologic alterations during growth and maturation of cardiac myocytes. AN - 80320572; 2088117 AB - Alteration of growth and development of cells exposed to ethanol during embryogenesis contributes to dysmorphism. The mechanism(s) of these alterations remains an enigma. This paper describes studies of an in vitro cardiac myocyte model in which the major effort was to investigate growth and development parameters in an obligate interacting multicellular system. The well defined events of in vitro myogenesis allow for documentation or dysgenesis and altered growth in the presence of the taratogen, ethanol. The cells exposed to ethanol did not mature morphologically or functionally compared with controls. Increasing concentrations of ethanol appear to have a graded damaging effect. The greater the concentration of ethanol the more profound the dyssynchronous growth. The morphologic correlates were multinucleation, and alteration in the ultrastructural organization of cell-cell contacts and myofilaments. Correlation of these findings with those observed in dysgenic muscle of human infants and rat pups exposed to ethanol in utero, may provide at least a partial understanding of the teratogenic manifestation of ethanol in embryogenesis and organogenesis. JF - Alcoholism, clinical and experimental research AU - Adickes, E D AU - Mollner, T J AU - Lockwood, S K AD - Research Service, Omaha Veterans Administration Hospital, Nebraska. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 827 EP - 831 VL - 14 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Myofibrils -- drug effects KW - Dose-Response Relationship, Drug KW - Myofibrils -- ultrastructure KW - Rabbits KW - Myocardial Contraction -- drug effects KW - Intercellular Junctions -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Cell Count -- drug effects KW - Cells, Cultured KW - Intercellular Junctions -- ultrastructure KW - Myocardial Contraction -- physiology KW - Microscopy, Electron KW - Fluorescent Antibody Technique KW - Myocardium -- cytology KW - Cell Division -- drug effects KW - Ethanol -- toxicity KW - Fetal Alcohol Spectrum Disorders -- pathology KW - Cell Differentiation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80320572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Ethanol+induced+morphologic+alterations+during+growth+and+maturation+of+cardiac+myocytes.&rft.au=Adickes%2C+E+D%3BMollner%2C+T+J%3BLockwood%2C+S+K&rft.aulast=Adickes&rft.aufirst=E&rft.date=1990-12-01&rft.volume=14&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-20 N1 - Date created - 1991-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Iodide-induced hypothyroidism in patients after thyroid resection. AN - 80291625; 2127746 AB - The purpose of this investigation was to determine whether an intrinsic defect in thyroid hormone production is required for the development of iodide-induced hypothyroidism or does it also develop in TSH-stimulated normal thyroid tissue. To answer this question, we studied the response to iodine administration (180 mg iodide daily for 3-4 months) in eight euthyroid patients who had had partial thyroidectomies 2 months to 10 years previously for benign thyroid nodules, and in three euthyroid control subjects. In all 11 euthyroid patients, basal serum TSH concentrations increased during iodide administration. In six of the eight patients who had previous thyroid operations and in two of the three control patients, basal serum TSH concentrations increased into the abnormal range (greater than 6 U ml-1). Increased serum TSH concentrations were noted as early as 1 week after potassium iodide had been started and the increased levels persisted during the period of iodide administration. Although basal values for serum TSH concentration were initially within the normal range, those patients with highest basal serum TSH values developed the greatest increase in TSH in response to potassium iodine. Among the eight patients treated by partial thyroidectomy, serum T4 concentrations decreased in five, serum T3 concentration decreased in three and all five developed mild symptoms of hypothyroidism while receiving iodide. Serum T4 concentrations also decreased slightly in two of the three control patients. Serum total iodine levels increased from 7.0 +/- 0.5 to 315.7 +/- 108.6 g dl-1 (mean-+/- standard error) during potassium iodide administration, but there was no correlation between the level of serum iodide concentration achieved and inhibition of thyroid function.(ABSTRACT TRUNCATED AT 250 WORDS) JF - European journal of clinical investigation AU - Clark, O H AU - Cavalieri, R R AU - Moser, C AU - Ingbar, S H AD - Surgical Service, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 573 EP - 580 VL - 20 IS - 6 SN - 0014-2972, 0014-2972 KW - Triiodothyronine KW - 06LU7C9H1V KW - Potassium Iodide KW - 1C4QK22F9J KW - Thyrotropin KW - 9002-71-5 KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Triiodothyronine -- blood KW - Thyrotropin -- blood KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Thyroxine -- blood KW - Male KW - Female KW - Potassium Iodide -- administration & dosage KW - Hypothyroidism -- etiology KW - Hypothyroidism -- blood KW - Thyroidectomy -- adverse effects KW - Potassium Iodide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80291625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+investigation&rft.atitle=Iodide-induced+hypothyroidism+in+patients+after+thyroid+resection.&rft.au=Clark%2C+O+H%3BCavalieri%2C+R+R%3BMoser%2C+C%3BIngbar%2C+S+H&rft.aulast=Clark&rft.aufirst=O&rft.date=1990-12-01&rft.volume=20&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+investigation&rft.issn=00142972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-30 N1 - Date created - 1991-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nifedipine in the treatment of tardive dyskinesia. AN - 80256624; 1981070 AB - There have been several case reports of improvement in tardive dyskinesia (TD) after treatment with calcium-blocking agents. We have conducted prior single-blind (rater-blind) studies of verapamil and diltiazem and found a statistically significant improvement in TD with verapamil, and a small improvement that did not reach statistical improvement after diltiazem treatment. We now report a single-blind (rater-blind) study of a third calcium antagonist, nifedipine, in the treatment of TD. Nifedipine (30-60 mg/day) was administered to eight schizophrenic patients with TD. Mean AIMS scores on items 1-7 decreased from 12.9 +/- 2.0 (SD) at baseline to 10.8 +/- 2.7 after treatment (t = 3.66, p = 0.01). All subjects were able to tolerate the maximal dose of nifedipine without significant side effects. TD is known to be affected by drugs that affect dopamine neurotransmission. Several lines of pre-clinical and clinical evidence suggest interactions between the calcium antagonists and the CNS dopamine system and provide a possible explanation for the effects on TD seen with calcium antagonists. JF - Journal of clinical psychopharmacology AU - Duncan, E AU - Adler, L AU - Angrist, B AU - Rotrosen, J AD - New York Veterans Administration Medical Center, NY 10010. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 414 EP - 416 VL - 10 IS - 6 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Nifedipine KW - I9ZF7L6G2L KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Single-Blind Method KW - Humans KW - Adult KW - Neurologic Examination -- drug effects KW - Middle Aged KW - Male KW - Dyskinesia, Drug-Induced -- drug therapy KW - Nifedipine -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80256624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Nifedipine+in+the+treatment+of+tardive+dyskinesia.&rft.au=Duncan%2C+E%3BAdler%2C+L%3BAngrist%2C+B%3BRotrosen%2C+J&rft.aulast=Duncan&rft.aufirst=E&rft.date=1990-12-01&rft.volume=10&rft.issue=6&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic therapy for congestive heart failure with benazepril HCl, a new angiotensin converting enzyme inhibitor. AN - 80189784; 2264573 AB - Benazepril HCl is an orally effective angiotensin converting enzyme (ACE) inhibitor previously shown to have significant acute hemodynamic benefits in patients with congestive heart failure. In this study, 21 patients with New York Heart Association Class III or IV congestive heart failure were treated with 2 to 15 mg of benazepril HCl as a single daily oral dose for 28 days to determine the clinical and hemodynamic value of chronic therapy. Each patient underwent clinical evaluation during the 28-day period, as well as invasive hemodynamic studies on the first two and last two days of the trial. Plasma ACE activity and aldosterone levels fell significantly and renin levels rose after therapy. Benazepril HCl produced significant (p less than 0.01) reductions in arterial pressure and systemic vascular resistance, with corresponding increases in cardiac output and decreases in pulmonary artery wedge pressure. Responses after 28 days of therapy were equivalent to those after the initial doses. Clinical effects included reduced rest, exertional and paroxysmal nocturnal dyspnea, as well as reduced peripheral edema. Only one patient developed symptomatic orthostatic hypotension. Thus, benazepril HCl, given once daily, is an effective and well tolerated oral agent for the chronic treatment of advanced congestive heart failure. JF - The American journal of the medical sciences AU - Mirvis, D M AU - Insel, J AU - Boland, M J AU - Cinquegrani, M P AU - Ghali, J K AU - Rubin, S A AU - Shanes, J AU - DeSilva, J AU - Whalen, J J AD - Veterans Administration Medical Center, Memphis, TN. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 354 EP - 360 VL - 300 IS - 6 SN - 0002-9629, 0002-9629 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Benzazepines KW - Renin KW - EC 3.4.23.15 KW - benazepril KW - UDM7Q7QWP8 KW - Abridged Index Medicus KW - Index Medicus KW - Renin -- blood KW - Hemodynamics -- drug effects KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Benzazepines -- pharmacology KW - Heart Failure -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Benzazepines -- adverse effects KW - Benzazepines -- therapeutic use KW - Heart Failure -- physiopathology KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80189784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Chronic+therapy+for+congestive+heart+failure+with+benazepril+HCl%2C+a+new+angiotensin+converting+enzyme+inhibitor.&rft.au=Mirvis%2C+D+M%3BInsel%2C+J%3BBoland%2C+M+J%3BCinquegrani%2C+M+P%3BGhali%2C+J+K%3BRubin%2C+S+A%3BShanes%2C+J%3BDeSilva%2C+J%3BWhalen%2C+J+J&rft.aulast=Mirvis&rft.aufirst=D&rft.date=1990-12-01&rft.volume=300&rft.issue=6&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium ionophores injure alveolar epithelial cells: relation to phospholipase activity. AN - 80176952; 2124422 AB - Phospholipases and certain of their hydrolytic products are toxic to alveolar epithelial cells. Since many intracellular phospholipases are Ca2+ dependent, we postulated that elevating cytosolic Ca2+ with ionophores might cause epithelial injury via phospholipase activation. Isolated perfused hamster lungs exposed to an Ca2+ ionophore A23187 develop functional evidence of severe epithelial injury. Ultrastructural studies show widespread lysis of type I epithelial cells, with only minimal abnormalities in other lung cells, including the microvascular endothelium. Analysis of whole lung lipid extracts reveals a modest elevation in free arachidonic acid but no changes in other putative products of phospholipase activity. Parallel studies were performed in cultured cells of pulmonary origin. As measured by 51Cr release, A23187 causes substantial cytotoxicity in 3-day-old cultures of rat type II alveolar epithelial cells (RAEC) but not in cultured bovine pulmonary artery endothelial cells (BPAEC). RAEC prelabeled with [14C]stearic acid [( 14C]SA) and [3H]arachidonic acid [( 3H]AA) release radiolabeled free fatty acids (FFA) in response to A23187 in a dose- and time-dependent manner that parallels the cytotoxicity index. Analyses of putative phospholipase products in cells radiolabeled with [14C]SA and [3H]AA, with [14C]choline, or with [14C]ethanolamine suggest that liberation of radiolabeled FFA may be due to several phospholipases but with principal activity being exhibited by a phospholipase C having specificity toward phosphatidylcholine and phosphatidylethanolamine. Prelabeled BPAEC release only minimal quantities of FFA in response to A23187 under the same conditions. These studies demonstrate that elevations of intracytoplasmic Ca2+ are capable of severely and selectively damaging alveolar epithelial cells and that the injury is associated with activation of intracellular phospholipases. These findings may have implications in regard to the pathogenesis of acute lung injury in humans. JF - The American journal of physiology AU - Rice, K L AU - Duane, P G AU - Mielke, G AU - Sinha, A A AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - L439 EP - L450 VL - 259 IS - 6 Pt 1 SN - 0002-9513, 0002-9513 KW - Arachidonic Acids KW - 0 KW - Diglycerides KW - Fatty Acids, Nonesterified KW - Phospholipids KW - Arachidonic Acid KW - 27YG812J1I KW - Calcimycin KW - 37H9VM9WZL KW - Phospholipases KW - EC 3.1.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Phospholipids -- metabolism KW - Arachidonic Acids -- metabolism KW - Epithelium -- drug effects KW - Endothelium, Vascular -- physiology KW - Rats KW - Cattle KW - Endothelium, Vascular -- drug effects KW - Cells, Cultured KW - Epithelium -- physiology KW - Lung -- ultrastructure KW - Lung -- drug effects KW - Microscopy, Electron KW - Lung -- enzymology KW - Cell Membrane Permeability KW - Fatty Acids, Nonesterified -- metabolism KW - Cricetinae KW - Diglycerides -- metabolism KW - Calcium -- metabolism KW - Phospholipases -- metabolism KW - Pulmonary Alveoli -- cytology KW - Calcium -- pharmacology KW - Calcimycin -- pharmacology KW - Pulmonary Alveoli -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80176952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Calcium+ionophores+injure+alveolar+epithelial+cells%3A+relation+to+phospholipase+activity.&rft.au=Rice%2C+K+L%3BDuane%2C+P+G%3BMielke%2C+G%3BSinha%2C+A+A%3BNiewoehner%2C+D+E&rft.aulast=Rice&rft.aufirst=K&rft.date=1990-12-01&rft.volume=259&rft.issue=6+Pt+1&rft.spage=L439&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-31 N1 - Date created - 1991-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of gastric mucosal cell proliferation by the fungicide captan: role of tyrosine kinases. AN - 80174591; 2260117 AB - Captan (1,2,3,6-tetrahydro-N-trichloromethylthiophthalmide), a widely used fungicide, has been shown to induce carcinoma in the gastrointestinal tract of rodents. However, little is known about the captan induction of early biochemical changes in the gastrointestinal tract. The present investigation examines the changes in gastric mucosal proliferative activity in 2-month-old Fischer 344 rats following a daily injection (s.c.) of captan (100 mg/kg body wt.) in DMSO while being infused (osmotic minipump) with the same compound (7.14 mg captan/kg body wt./h) for 2 weeks. The control rats received the vehicle the same way. The change in proliferative activity was related to tyrosine kinase (Tyr-k) activity and tyrosine-specific phosphorylation of protein(s) in gastric mucosal membranes since these intracellular events are thought to play an important role in proliferation, differentiation and transformation of cells. After 2 weeks of captan administration gastric mucosal DNA synthesis and thymidine kinase activity (indicators of proliferative activity) were increased by 330% (P less than 0.025) and 98% (P less than 0.025), respectively, when compared with the corresponding controls. Gastric mucosal DNA content was also increased by 90% (P less than 0.025) after administration of captan. These increases were associated with about 3-fold rise in Tyr-k activity and 2-fold increase in tyrosine phosphorylation of 6 mucosal membrane proteins with Mr of 105, 90, 60, 55, 48 and 37 kDa. We conclude that captan stimulates gastric mucosal cell proliferation, and activation of Tyr-k and tyrosine phosphorylation of certain membrane proteins may be important in the regulation of this process. JF - Toxicology letters AU - Wahby, M AU - Shelef, L A AU - Luk, G D AU - Majumdar, A P AD - Research Service, Veterans Administration Medical Center, Allen Park, MI 48101. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 189 EP - 198 VL - 54 IS - 2-3 SN - 0378-4274, 0378-4274 KW - Membrane Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Captan KW - EOL5G26Q9F KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Infusion Pumps KW - Membrane Proteins -- metabolism KW - Injections, Subcutaneous KW - Cell Division -- drug effects KW - DNA -- biosynthesis KW - Male KW - Phosphorylation -- drug effects KW - Gastric Mucosa -- enzymology KW - Captan -- toxicity KW - Thymidine Kinase -- metabolism KW - Gastric Mucosa -- drug effects KW - Protein-Tyrosine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80174591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Induction+of+gastric+mucosal+cell+proliferation+by+the+fungicide+captan%3A+role+of+tyrosine+kinases.&rft.au=Wahby%2C+M%3BShelef%2C+L+A%3BLuk%2C+G+D%3BMajumdar%2C+A+P&rft.aulast=Wahby&rft.aufirst=M&rft.date=1990-12-01&rft.volume=54&rft.issue=2-3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-29 N1 - Date created - 1991-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Expressive dysphasia possibly related to FK506 in two liver transplant recipients. AN - 80164126; 1701571 JF - Transplantation AU - Reyes, J AU - Gayowski, T AU - Fung, J AU - Todo, S AU - Alessiani, M AU - Starzl, T E AD - Veterans Administration Medical Center, University of Pittsburgh. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1043 EP - 1045 VL - 50 IS - 6 SN - 0041-1337, 0041-1337 KW - Anti-Bacterial Agents KW - 0 KW - Carrier Proteins KW - Immunosuppressive Agents KW - Amino Acid Isomerases KW - EC 5.1.1.- KW - Peptidylprolyl Isomerase KW - EC 5.2.1.8 KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Postoperative Complications KW - Carrier Proteins -- antagonists & inhibitors KW - Humans KW - Adult KW - Amino Acid Isomerases -- antagonists & inhibitors KW - Male KW - Female KW - Aphasia -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Liver Transplantation KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80164126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Expressive+dysphasia+possibly+related+to+FK506+in+two+liver+transplant+recipients.&rft.au=Reyes%2C+J%3BGayowski%2C+T%3BFung%2C+J%3BTodo%2C+S%3BAlessiani%2C+M%3BStarzl%2C+T+E&rft.aulast=Reyes&rft.aufirst=J&rft.date=1990-12-01&rft.volume=50&rft.issue=6&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-23 N1 - Date created - 1991-01-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1985 Jul 20;2(8447):153-4 [2862341] Res Publ Assoc Res Nerv Ment Dis. 1974;53:13-38 [4438815] Lancet. 1984 Nov 17;2(8412):1116-20 [6150182] N Engl J Med. 1987 Oct 1;317(14):861-6 [3306386] Ann Surg. 1990 Sep;212(3):295-305; discussion 306-7 [1697743] JAMA. 1990 Jul 4;264(1):63-7 [1693970] Ann Surg. 1978 Mar;187(3):236-40 [345984] Neurology. 1989 Apr;39(4):493-8 [2648187] Transplantation. 1989 Dec;48(6):1006-12 [2595761] Transplantation. 1990 Jan;49(1):215-6 [2301014] Nature. 1989 Oct 26;341(6244):755-7 [2477714] Nature. 1989 Oct 26;341(6244):758-60 [2477715] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence for decreased transport of PNMT protein in advanced Alzheimer's disease. AN - 80163666; 2254565 AB - Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme in the synthesis of epinephrine and a specific marker for adrenergic neurons. PNMT protein is decreased in axon terminals in brains from patients with Alzheimer's disease due to retrograde degeneration of epinephrine neurons. To determine the subcellular mechanism underlying retrograde degeneration, the distribution of PNMT between axon terminal and cell body was calculated in early and advanced Alzheimer cases compared with age-matched controls. In early Alzheimer's disease there is a decrease in PNMT in axon terminals and in total PNMT in epinephrine cell bodies and terminals compared with control values. There is no difference in the ratio of PNMT in cell body/axon terminal compared with controls. In contrast, in advanced Alzheimer's disease, PNMT activity increases by 124% in epinephrine neuronal cell bodies compared with controls. Immunochemical titration shows that this increased enzyme activity is due to an increase in PNMT protein. The cell body/axon terminal ratio of PNMT is increased 2.5-fold in advanced Alzheimer's disease compared with controls. These findings are consistent with the hypothesis that in early Alzheimer's disease there is a decreased synthesis or increased degradation of PNMT. However, in advanced Alzheimer's disease we propose that the accumulation of this enzyme in the perikarya results from a diminished transport of PNMT to axon terminals. We further postulate that epinephrine, the product of PNMT, and its further metabolites are endogenous neurotoxins. Therefore, the accumulation of PNMT in epinephrine cell bodies may contribute to the degeneration of these neurons in Alzheimer's disease. JF - Journal of the American Geriatrics Society AU - Burke, W J AU - Chung, H D AU - Marshall, G L AU - Gillespie, K N AU - Joh, T H AD - Department of Neurology, Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1275 EP - 1282 VL - 38 IS - 12 SN - 0002-8614, 0002-8614 KW - Phenylethanolamine N-Methyltransferase KW - EC 2.1.1.28 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Female KW - Neurons -- pathology KW - Brain -- enzymology KW - Phenylethanolamine N-Methyltransferase -- isolation & purification KW - Brain -- pathology KW - Alzheimer Disease -- enzymology KW - Phenylethanolamine N-Methyltransferase -- metabolism KW - Alzheimer Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80163666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Evidence+for+decreased+transport+of+PNMT+protein+in+advanced+Alzheimer%27s+disease.&rft.au=Burke%2C+W+J%3BChung%2C+H+D%3BMarshall%2C+G+L%3BGillespie%2C+K+N%3BJoh%2C+T+H&rft.aulast=Burke&rft.aufirst=W&rft.date=1990-12-01&rft.volume=38&rft.issue=12&rft.spage=1275&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-23 N1 - Date created - 1991-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surfactant replacement improves lung recoil in rabbit lungs after acid aspiration. AN - 80157149; 2252244 AB - We tested the hypothesis that surfactant replacement would be beneficial in the acid-aspiration model of acute lung injury. HCl (0.1 N, 2 ml/kg) was injected into the trachea of excised rabbit lungs (n = 8). Control lungs (n = 4) had no intervention. All were perfused with Tyrode's solution mixed 1:1 with autologous whole blood at 40 ml/min/kg for 30 min, and then degassed. A modified natural surfactant (Survanta, Ross Laboratories) was then injected into the trachea of four lungs injured with HCl (100 mg/kg at 25 mg/ml). Two quasi-static pressure-volume curves were determined. The mean alveolar pressures at 50, 60, 70, 80, and 90% of TLC were greater in the HCl group than in the control group (p less than 0.05). However, no difference was observed between the control lungs and those that received HCl + Survanta. In 13 anesthetized, paralyzed, and ventilated rabbits, deflation pressure-volume curves were determined from TLC to FRC (measured by helium dilution). Then, 0.1 N HCl (3 ml/kg) was injected into the trachea and, in seven, Survanta was instilled 5 min later. The mean alveolar pressures at 60, 70, 80, and 90% TLC were higher at 15 and 60 min in the HCl group compared with their pre-HCl time point (p less than 0.05). In the HCl + Survanta group, no differences were seen at 15 min, and only slight increased were seen at 60 min. No effect of surfactant replacement on arterial blood gases was observed. HCl aspiration increased recoil in both excised and in vivo lungs, and surfactant replacement with Survanta returned recoil to normal. JF - The American review of respiratory disease AU - Lamm, W J AU - Albert, R K AD - Medical Service, Veterans Administration Medical Center, Seattle, Washington. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1279 EP - 1283 VL - 142 IS - 6 Pt 1 SN - 0003-0805, 0003-0805 KW - Pulmonary Surfactants KW - 0 KW - Hydrochloric Acid KW - QTT17582CB KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Total Lung Capacity KW - Rabbits KW - Lung Compliance KW - Respiratory Distress Syndrome, Adult -- therapy KW - Lung -- physiopathology KW - Respiratory Distress Syndrome, Adult -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80157149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Surfactant+replacement+improves+lung+recoil+in+rabbit+lungs+after+acid+aspiration.&rft.au=Lamm%2C+W+J%3BAlbert%2C+R+K&rft.aulast=Lamm&rft.aufirst=W&rft.date=1990-12-01&rft.volume=142&rft.issue=6+Pt+1&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am Rev Respir Dis. 1991 Aug;144(2):468-9 [1859079] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate. AN - 80149256; 2123565 AB - Individuals receiving lithium carbonate commonly have nephrogenic diabetes insipidus. There is no effective and practical treatment for this condition. We have found that large doses of desmopressin (DDAVP) may provide effective therapy without adverse effects. A recent report showed that indomethacin improved nephrogenic diabetes insipidus that had persisted after the lithium therapy was discontinued. We have provided additional evidence that indomethacin may be effective, even when treatment with lithium is continued. We also have shown that indomethacin together with desmopressin can markedly decrease polyuria, though indomethacin must be used with care because it may impair renal function. JF - Southern medical journal AU - Weinstock, R S AU - Moses, A M AD - Veterans Administration Medical Center, Syracuse, NY. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1475 EP - 1477 VL - 83 IS - 12 SN - 0038-4348, 0038-4348 KW - Antiviral Agents KW - 0 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Lithium KW - 9FN79X2M3F KW - Deamino Arginine Vasopressin KW - ENR1LLB0FP KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Drug Therapy, Combination KW - Drug Evaluation KW - Humans KW - Adult KW - Injections, Subcutaneous KW - Drug Synergism KW - Female KW - Deamino Arginine Vasopressin -- administration & dosage KW - Deamino Arginine Vasopressin -- therapeutic use KW - Kidney Diseases -- blood KW - Kidney Diseases -- urine KW - Indomethacin -- therapeutic use KW - Diabetes Insipidus -- chemically induced KW - Diabetes Insipidus -- urine KW - Antiviral Agents -- adverse effects KW - Lithium -- adverse effects KW - Indomethacin -- administration & dosage KW - Kidney Diseases -- drug therapy KW - Diabetes Insipidus -- blood KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80149256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Desmopressin+and+indomethacin+therapy+for+nephrogenic+diabetes+insipidus+in+patients+receiving+lithium+carbonate.&rft.au=Weinstock%2C+R+S%3BMoses%2C+A+M&rft.aulast=Weinstock&rft.aufirst=R&rft.date=1990-12-01&rft.volume=83&rft.issue=12&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-17 N1 - Date created - 1991-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Actin architecture of cultured human thyroid cancer cells: predictor of differentiation? AN - 80131265; 2247845 AB - The actin cytoskeleton is important for cell structure and motility. A disordered actin architecture has been correlated with a high metastatic potential in melanoma, fibrosarcoma, and colon cancer models. Thyrotropin is known to induce growth and differentiation in cultured thyroid cells, whereas the carcinogenic phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) causes dedifferentiation and malignant transformation in many cell lines. We therefore assessed the effect of thyrotropin and TPA on the actin architecture of FTC-133 human follicular thyroid cancer cells in continuous culture. Staining of filamentous actin with rhodamine phalloidin showed that 1 mU/ml or 30 mU/ml thyrotropin-induced actin polymerization was detectable at 1 hour but more notable at 24 hours. Similarly TPA (0.008 to 10 mumol/L) caused rapid actin fiber disruption and redistribution to the cell periphery. Secondary antibody staining for alpha-actinin, a protein that binds and crosslinks actin, was more prominent after treatment with thyrotropin but decreased after TPA. These findings indicate that the actin cytoskeleton has a dynamic response to trophic factors. Thyrotropin promoted actin polymerization, but TPA caused depolymerization. These effects may correlate with cellular alpha-actinin levels. Actin architecture may therefore reflect the state of differentiation of thyroid tumor cells. JF - Surgery AU - Demeure, M J AU - Hughes-Fulford, M AU - Goretzki, P E AU - Duh, Q Y AU - Clark, O H AD - Surgical Service Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 986 EP - 92; discussion 992-3 VL - 108 IS - 6 SN - 0039-6060, 0039-6060 KW - Actins KW - 0 KW - Thyrotropin KW - 9002-71-5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Space life sciences KW - Thyrotropin -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Actin Cytoskeleton -- ultrastructure KW - Humans KW - Actin Cytoskeleton -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Differentiation KW - Forecasting KW - Time Factors KW - Thyroid Neoplasms -- ultrastructure KW - Thyroid Neoplasms -- metabolism KW - Actins -- metabolism KW - Thyroid Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80131265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery&rft.atitle=Actin+architecture+of+cultured+human+thyroid+cancer+cells%3A+predictor+of+differentiation%3F&rft.au=Demeure%2C+M+J%3BHughes-Fulford%2C+M%3BGoretzki%2C+P+E%3BDuh%2C+Q+Y%3BClark%2C+O+H&rft.aulast=Demeure&rft.aufirst=M&rft.date=1990-12-01&rft.volume=108&rft.issue=6&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Surgery&rft.issn=00396060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-08 N1 - Date created - 1991-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dilatation of radiation-induced sigmoid stricture using sequential Savary-Guilliard dilators. A combined radiologic-endoscopic approach. AN - 80123348; 2242702 JF - Diseases of the colon and rectum AU - Triadafilopoulos, G AU - Sarkisian, M AD - Department of Medicine, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1065 EP - 1067 VL - 33 IS - 12 SN - 0012-3706, 0012-3706 KW - Index Medicus KW - Fluoroscopy KW - Constriction, Pathologic -- therapy KW - Combined Modality Therapy KW - Humans KW - Constriction, Pathologic -- etiology KW - Radiotherapy -- adverse effects KW - Dilatation -- methods KW - Colon, Sigmoid -- pathology KW - Radiation Injuries -- therapy KW - Dilatation -- instrumentation KW - Colon, Sigmoid -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80123348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diseases+of+the+colon+and+rectum&rft.atitle=Dilatation+of+radiation-induced+sigmoid+stricture+using+sequential+Savary-Guilliard+dilators.+A+combined+radiologic-endoscopic+approach.&rft.au=Triadafilopoulos%2C+G%3BSarkisian%2C+M&rft.aulast=Triadafilopoulos&rft.aufirst=G&rft.date=1990-12-01&rft.volume=33&rft.issue=12&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Diseases+of+the+colon+and+rectum&rft.issn=00123706&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-03 N1 - Date created - 1991-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diarrhea. AN - 80106115; 2235642 AB - Diarrhea is one manifestation of GI disturbance. Symptoms may be acute if caused by such things as infections, drug reactions, alterations in diet, heavy metal poisoning, or fecal impaction. Chronic diarrhea is a symptom of GI diseases such as irritable bowel syndrome, lactase deficiency, cancer of the colon, inflammatory bowel disease, and malabsorption diseases. Chronic diarrhea may also be associated with GI surgery, radiation therapy, laxative abuse, alcohol abuse, and chemotherapeutic agents. When interventions are required to deal with diarrhea, they may include such things as alteration in tube feeding products and methods of administration, fluid replacement by oral rehydration procedures, a rapid return to feeding, and education aimed at the health information clients need to prevent or control the symptom of diarrhea. JF - The Nursing clinics of North America AU - Wadle, K R AD - Nursing Service for Education, Veterans Administration Medical Center, Knoxville, Iowa. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 901 EP - 908 VL - 25 IS - 4 SN - 0029-6465, 0029-6465 KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Humans KW - Diarrhea -- nursing KW - Diarrhea -- therapy KW - Diarrhea -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80106115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nursing+clinics+of+North+America&rft.atitle=Diarrhea.&rft.au=Wadle%2C+K+R&rft.aulast=Wadle&rft.aufirst=K&rft.date=1990-12-01&rft.volume=25&rft.issue=4&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=The+Nursing+clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-12 N1 - Date created - 1990-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phase II trial of interferon gamma and monoclonal antibody 17-1A in pancreatic cancer: biologic and clinical effects. AN - 80088734; 2121912 AB - Thirty patients with advanced measurable pancreatic adenocarcinoma were entered onto a phase II trial with recombinant interferon gamma (Biogen, Cambridge, MA; 10(6) U/m2 daily for 4 days) and monoclonal antibody (Mab) 17-1A (Centocor, Malvern, PA; 150 mg in autologous leukocytes on days 2, 3, and 4 following interferon infusion). The effect of a single interferon gamma treatment on natural and antibody-dependent cellular cytotoxicity (ADCC), Fc receptor occupancy by antibody, and human leukocyte antigen-DR (HLA-DR) expression on monocytes and lymphocytes was also studied. Toxicity was modest and generally limited to grade I to II fever, nausea and vomiting, and hepatotoxicity. Five patients were considered to be nonassessable for response. Of the 25 assessable patients, one objective response (complete remission for a duration of 4 months) was observed. Stable disease for 2 months or greater was noted in nine patients. The median survival for the group was 5 months. Analysis of cytotoxicity data obtained prior to treatment showed reduced natural cytotoxic activity in these patients compared with normal volunteers. A significant improvement in natural cytotoxic activity to normal levels occurred within 24 hours following the interferon gamma infusion. This was also associated with augmented antibody-dependent cellular cytotoxicity. Although HLA-DR expression was not increased on either monocytes or lymphocytes, an increased capacity of both lymphocytes and monocytes to bind Mab 17-1A was observed. In all in vitro assays of ADCC, the presence of antibody excess was associated with improved cytolytic activity. In spite of the favorable modulation of cytolytic activity and improved ability of effector cells to bind Mab, we failed to demonstrated adequate clinical efficacy in the treatment of patients with pancreatic adenocarcinoma using this dose and schedule of interferon gamma and Mab 17-1A. Future trials will focus on alternate schedules of Mab 17-1A with the hope of improving tumor antigen saturation and circulating levels of infused antibody. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Tempero, M A AU - Sivinski, C AU - Steplewski, Z AU - Harvey, E AU - Klassen, L AU - Kay, H D AD - Veterans Administration Medical Center, Omaha, NE. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 2019 EP - 2026 VL - 8 IS - 12 SN - 0732-183X, 0732-183X KW - Antibodies, Monoclonal KW - 0 KW - Recombinant Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Antibody-Dependent Cell Cytotoxicity KW - Immunity, Cellular KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Remission Induction KW - Pancreatic Neoplasms -- therapy KW - Interferon-gamma -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Adenocarcinoma -- therapy KW - Adenocarcinoma -- immunology KW - Pancreatic Neoplasms -- immunology KW - Interferon-gamma -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80088734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+trial+of+interferon+gamma+and+monoclonal+antibody+17-1A+in+pancreatic+cancer%3A+biologic+and+clinical+effects.&rft.au=Tempero%2C+M+A%3BSivinski%2C+C%3BSteplewski%2C+Z%3BHarvey%2C+E%3BKlassen%2C+L%3BKay%2C+H+D&rft.aulast=Tempero&rft.aufirst=M&rft.date=1990-12-01&rft.volume=8&rft.issue=12&rft.spage=2019&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-26 N1 - Date created - 1990-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Host response to mycobacterial infection in the alcoholic rat. AN - 80076189; 2227286 AB - Animals, chronically treated with alcohol, were inoculated with mycobacteria (bacillus Calmette-Guérin, 10.2 x 10(6) organisms) into the spleen to produce a granulomatous hepatitis. Before infection, chronic alcohol ingestion was associated with a depressed skin test response to phytohemagglutinin, 71.7% of baseline (P = 0.009). Mycobacterial (bacillus Calmette-Guérin) infection stimulated phytohemagglutinin skin test response to 417% of baseline in controls and 299% in alcoholics (P less than 0.001). The hepatic granuloma response was altered with smaller but more numerous granulomas (mean +/- SEM, 81.2 +/- 1.5 microns2 of area with a frequency of 1.8 granulomas per field in alcoholics vs. 129.8 +/- 5.71 microns2 and 1.2 granulomas per field in controls; P less than 0.001). These changes were associated with a 10-fold increase in colony-forming units per gram of liver (54.5 +/- 18.2 in alcoholics vs. 5.6 +/- 1.83 in controls; P = 0.0006). This model offers precise parameters for host response to infection and indicates that alcohol significantly impairs the clearing capacity for mycobacteria from the liver. JF - Gastroenterology AU - Mendenhall, C L AU - Grossman, C J AU - Roselle, G A AU - Ghosn, S AU - Gartside, P S AU - Rouster, S D AU - Chalasani, P V AU - Schmitt, G AU - Martin, K AU - Lamping, K AD - Research Service, Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1723 EP - 1726 VL - 99 IS - 6 SN - 0016-5085, 0016-5085 KW - Phytohemagglutinins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Skin Tests KW - Granuloma -- etiology KW - Mycobacterium bovis KW - Rats KW - Rats, Inbred Strains KW - Granuloma -- pathology KW - Skin -- immunology KW - Liver Diseases -- pathology KW - Liver Diseases -- etiology KW - Colony-Forming Units Assay KW - Male KW - Mycobacterium Infections -- physiopathology KW - Mycobacterium Infections -- immunology KW - Mycobacterium Infections -- complications KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80076189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Host+response+to+mycobacterial+infection+in+the+alcoholic+rat.&rft.au=Mendenhall%2C+C+L%3BGrossman%2C+C+J%3BRoselle%2C+G+A%3BGhosn%2C+S%3BGartside%2C+P+S%3BRouster%2C+S+D%3BChalasani%2C+P+V%3BSchmitt%2C+G%3BMartin%2C+K%3BLamping%2C+K&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1990-12-01&rft.volume=99&rft.issue=6&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-12 N1 - Date created - 1990-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 1991 Aug;101(2):593-4 [2065935] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Koro: Proposed Classification for DSM-IV AN - 61255390; 91X5459 AB - The ancient Asian psychiatric disorder of koro -- ie, the fear of genital retraction into the abdomen, & the possibility of consequent death -- is discussed in terms of debates & disagreements about the nature of the phenomenon. Case studies are presented, the history of the syndrome is reviewed, & its relatively wide prevalence is confirmed. Cultural considerations relating to koro are discussed, but isolated cases involving non-Asian patients are noted also. After outlining past attempts to define & classify koro, a DSM-IV classification is proposed that could include koro along with other culture-related syndromes. The proposed classification is appended in its entirety. 1 Figure, 1 Appendix, 27 References. J. W. Stanton JF - The American Journal of Psychiatry AU - Bernstein, Ruth L AU - Gaw, Albert C AD - c/o Gaw -- Dept Psychiatry Edith Nourse Rogers Memorial Veterans Administration Hospital, 200 Springs Rd Bedford MA 01730 Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1670 EP - 1674 VL - 147 IS - 12 SN - 0002-953X, 0002-953X KW - Asian psychiatric disorder koro, proposed DSM-IV classification KW - Diagnosis KW - Fear KW - Genitals KW - Mental Illness KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) KW - 0514: culture and social structure; social anthropology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61255390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Koro%3A+Proposed+Classification+for+DSM-IV&rft.au=Bernstein%2C+Ruth+L%3BGaw%2C+Albert+C&rft.aulast=Bernstein&rft.aufirst=Ruth&rft.date=1990-12-01&rft.volume=147&rft.issue=12&rft.spage=1670&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Genitals; Mental Illness; Fear; Diagnosis ER - TY - JOUR T1 - Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation. AN - 80125497; 2173710 AB - To assess the functional significance of phosphorylation of the epidermal growth factor (EGF) receptor at Thr654, we compared the effects of 12-O-tetradecanoyl-13-acetate (TPA) on ligand-induced internalization and down-regulation between wild-type and mutant receptors that contain an alanine substitution at position 654. Activation of protein kinase C with TPA blocked EGF-induced internalization and down-regulation of Thr654 receptors and inhibited in vivo tyrosine kinase activity by 80%. TPA did not inhibit transferrin receptor internalization or constitutive EGF receptor internalization, suggesting that protein kinase C activation inhibits only the ligand-induced process. Inhibition by TPA of induced internalization, down-regulation, and kinase activity required threonine at position 654 since full-length Ala654 EGF receptors were significantly resistant to TPA inhibition of these ligand-induced activities. However, C'-terminal truncation further enhanced this resistance to TPA inhibition. The EGF-dependent internalization of kinase-inactive receptors truncated at residue 1022 was also impaired by TPA in Thr654 receptors, but not in Ala654 receptors, indicating that phosphorylation at Thr654 also interferes with tyrosine kinase-independent receptor activities. We conclude that the dominant regulatory effect of protein kinase C on the EGF receptor is mediated through phosphorylation at Thr654 which effectively inactivates the receptor. The submembrane region of the EGF receptor appears to regulate transmission of conformational information from the extracellular ligand-binding site to the cytoplasmic kinase and regulatory domains. JF - The Journal of biological chemistry AU - Lund, K A AU - Lazar, C S AU - Chen, W S AU - Walsh, B J AU - Welsh, J B AU - Herbst, J J AU - Walton, G M AU - Rosenfeld, M G AU - Gill, G N AU - Wiley, H S AD - Veterans Administration Medical Center, Salt Lake City, Utah. Y1 - 1990/11/25/ PY - 1990 DA - 1990 Nov 25 SP - 20517 EP - 20523 VL - 265 IS - 33 SN - 0021-9258, 0021-9258 KW - Ligands KW - 0 KW - Receptors, Transferrin KW - Threonine KW - 2ZD004190S KW - Epidermal Growth Factor KW - 62229-50-9 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Phosphorylation KW - Transfection KW - Kinetics KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Receptors, Transferrin -- drug effects KW - Cell Line KW - Receptors, Transferrin -- metabolism KW - Receptor, Epidermal Growth Factor -- drug effects KW - Protein Kinase C -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - Down-Regulation KW - Protein-Tyrosine Kinases -- metabolism KW - Epidermal Growth Factor -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80125497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Phosphorylation+of+the+epidermal+growth+factor+receptor+at+threonine+654+inhibits+ligand-induced+internalization+and+down-regulation.&rft.au=Lund%2C+K+A%3BLazar%2C+C+S%3BChen%2C+W+S%3BWalsh%2C+B+J%3BWelsh%2C+J+B%3BHerbst%2C+J+J%3BWalton%2C+G+M%3BRosenfeld%2C+M+G%3BGill%2C+G+N%3BWiley%2C+H+S&rft.aulast=Lund&rft.aufirst=K&rft.date=1990-11-25&rft.volume=265&rft.issue=33&rft.spage=20517&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-28 N1 - Date created - 1990-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia. AN - 80112096; 1700592 AB - The effects of oral mexiletine on left ventricular (LV) ejection fraction (EF) and ventricular arrhythmias--and a possible relation between these effects--were evaluated during 3 months of therapy in 29 patients with chronic ventricular premature complexes (VPCs) and a moderately reduced to normal LVEF by 24-hour Holter monitoring and by radionuclide ventriculography at rest and during maximum tolerable exercise testing. After an average titration period of 13 days, a mean daily mexiletine dose of 739 mg was maintained throughout the treatment. At the end of titration and after 3 months of treatment, patients with a baseline LVEF less than or equal to 40% (group 2) responded with a median reduction of the hourly VPC rate by 90 and 81%, respectively, compared with 79 and 72% in those with a baseline LVEF greater than 40% (group 1). Couplets and runs of ventricular tachycardia were almost completely suppressed in nearly all patients. A single patient had a proarrhythmic increase in VPCs during treatment. Compared with baseline, there were no significant changes in resting or exercise LVEF after 1 or 3 months of treatment in either of the 2 groups of patients. No correlation was found between treatment-induced changes in arrhythmia frequency and in resting EF. No symptoms of congestive heart failure developed. The study confirms that long-term use of mexiletine is efficacious and relatively free of cardiac depressant effects even in patients with diminished LV function. JF - The American journal of cardiology AU - Singh, S AU - Klein, R AU - Eisenberg, B AU - Hughes, E AU - Shand, M AU - Doherty, P AD - Veterans Administration Medical Center, Cardiology Section, Washington, DC 20422. Y1 - 1990/11/15/ PY - 1990 DA - 1990 Nov 15 SP - 1222 EP - 1227 VL - 66 IS - 17 SN - 0002-9149, 0002-9149 KW - Mexiletine KW - 1U511HHV4Z KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test KW - Electrocardiography, Ambulatory KW - Tachycardia -- drug therapy KW - Humans KW - Aged KW - Middle Aged KW - Radionuclide Ventriculography KW - Stroke Volume -- drug effects KW - Time Factors KW - Male KW - Ventricular Function, Left -- drug effects KW - Mexiletine -- adverse effects KW - Cardiac Complexes, Premature -- drug therapy KW - Mexiletine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80112096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Long-term+effect+of+mexiletine+on+left+ventricular+function+and+relation+to+suppression+of+ventricular+arrhythmia.&rft.au=Singh%2C+S%3BKlein%2C+R%3BEisenberg%2C+B%3BHughes%2C+E%3BShand%2C+M%3BDoherty%2C+P&rft.aulast=Singh&rft.aufirst=S&rft.date=1990-11-15&rft.volume=66&rft.issue=17&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-14 N1 - Date created - 1990-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxic effects of lead on neuronal development and function. AN - 80322793; 2088752 AB - The effects of lead on the development of the nervous system are of immediate concern to human health. While it is clear that lead can affect neuronal development at levels of exposure within the range found in the environment, the particular mechanism of the disruption is not readily ascertained. Lack of knowledge of the mechanisms of lead-induced damaged hampers its treatment and prevention. The goal of our research is to develop a model system in which the effects of lead on central nervous system development can be demonstrated. The complexity of the brain hampers such investigations because often it is not clear if apparent toxic effects represents changes secondary to somatic changes, such as endocrine or hematological defects, that could alter brain development, or even transneuronal effects caused by toxicity at a distal site that deprives a brain area of a synaptic input needed for its proper development. A related problem is the redundancy of compensatory systems in the brain. Such system may disguise the severity of the initial toxic insult and themselves can cause functional disturbances. To study neuronal development in a system that minimizes such difficulties, we have grafted discrete brain regions derived from rat fetuses into the anterior chamber of the eye of adult hosts. The brain pieces continue organotypic development of the eye, but are isolated from possible secondary changes due to alterations in the development of the endocrine and other somatic systems because the adult host has these systems already fully developed. Similarly, effects mediated by connecting brain areas are minimized since the transplant is isolated in the anterior chamber of the eye.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental health perspectives AU - Freedman, R AU - Olson, L AU - Hoffer, B J AD - Department of Psychiatry, Denver Veterans Administration Medical Center, CO 80262. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 27 EP - 33 VL - 89 SN - 0091-6765, 0091-6765 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Rats KW - Iris -- innervation KW - Adrenergic Fibers -- drug effects KW - Animals KW - Purkinje Cells -- drug effects KW - Adrenergic Fibers -- physiology KW - Cerebellum -- transplantation KW - Electrophysiology KW - Anterior Chamber -- innervation KW - Purkinje Cells -- physiology KW - Central Nervous System -- growth & development KW - Central Nervous System -- physiology KW - Lead -- toxicity KW - Central Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80322793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Toxic+effects+of+lead+on+neuronal+development+and+function.&rft.au=Freedman%2C+R%3BOlson%2C+L%3BHoffer%2C+B+J&rft.aulast=Freedman&rft.aufirst=R&rft.date=1990-11-01&rft.volume=89&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-28 N1 - Date created - 1991-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Neurol. 1969 Jan;23(1):120-39 [5765001] Environ Res. 1981 Oct;26(1):69-80 [7297534] Exp Neurol. 1974 Jan;42(1):146-57 [4856900] Environ Health Perspect. 1974 May;7:17-25 [4831139] Brain Res. 1974 Oct 18;79(2):165-84 [4424939] Neuropharmacology. 1975 May-Jun;14(5-6):431-44 [1171389] Toxicology. 1975 Nov;5(2):175-91 [174250] J Neuropathol Exp Neurol. 1977 Jan;36(1):169-93 [833616] Toxicol Appl Pharmacol. 1977 Jun;40(3):449-61 [882981] Pharmacol Biochem Behav. 1977 Jul;7(1):37-42 [561962] Proc Natl Acad Sci U S A. 1978 Feb;75(2):1009-12 [273212] Life Sci. 1978 Sep 4;23(9):877-88 [30015] N Engl J Med. 1979 Mar 29;300(13):689-95 [763299] Pharmacol Biochem Behav. 1979 May;10(5):733-42 [115012] Environ Res. 1980 Jun;22(1):224-36 [7418681] Science. 1973 Dec 7;182(4116):1022-4 [4795926] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ionic mechanisms in spontaneous vasomotion of the rat basilar artery in vivo. AN - 80318920; 2086768 AB - 1. The goal of this study was to examine ionic mechanisms that modulate spontaneous rhythmic changes in vascular calibre or 'vasomotion' in the basilar artery in vivo. 2. Diameter of the basilar artery was measured through a craniotomy in anaesthetized rats under control conditions and during topical application of antagonists or alteration in the ionic composition of artificial cerebrospinal fluid (CSF). 3. Both Ca2(+)-free CSF and the Ca2+ channel blocker, nimodipine, produced moderate dilatation of the basilar artery and abolished vasomotion. Increasing the concentration of Ca2+ in CSF from 1.7 to 5.0 mM did not affect the frequency of vasomotion, although the amplitude was increased slightly. 4. Both K(+)-free CSF and ouabain produced mild to moderate vasoconstriction and abolished vasomotion. In contrast, increasing the concentration of K+ in CSF produced vasodilatation of the basilar artery and decreased or abolished vasomotion depending on the degree of vasodilatation. 5. Tetrodotoxin had no effect on vasomotion. 6. These results suggest that vasomotion of the basilar artery in vivo is dependent on extracellular Ca2+ and K+, and on the activity of Na(+)-K(+)-ATPase, and not dependent on Na+ channel. JF - The Journal of physiology AU - Fujii, K AU - Heistad, D D AU - Faraci, F M AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 389 EP - 398 VL - 430 SN - 0022-3751, 0022-3751 KW - Tetraethylammonium Compounds KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - Nimodipine KW - 57WA9QZ5WH KW - Ouabain KW - 5ACL011P69 KW - Tetraethylammonium KW - 66-40-0 KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Basilar Artery -- physiology KW - Nimodipine -- pharmacology KW - Tetraethylammonium Compounds -- pharmacology KW - Tetrodotoxin -- pharmacology KW - Ouabain -- pharmacology KW - Male KW - Vasomotor System -- physiology KW - Potassium -- physiology KW - Vasomotor System -- drug effects KW - Calcium -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80318920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+physiology&rft.atitle=Ionic+mechanisms+in+spontaneous+vasomotion+of+the+rat+basilar+artery+in+vivo.&rft.au=Fujii%2C+K%3BHeistad%2C+D+D%3BFaraci%2C+F+M&rft.aulast=Fujii&rft.aufirst=K&rft.date=1990-11-01&rft.volume=430&rft.issue=&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+physiology&rft.issn=00223751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-23 N1 - Date created - 1991-05-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Stroke. 1986 Mar-Apr;17(2):225-8 [3961831] Angiology. 1955 Aug;6(4):291-308 [13275736] J Physiol. 1987 Jun;387:115-23 [3116212] Am J Physiol. 1988 Jan;254(1 Pt 2):H28-33 [3337256] Am J Physiol. 1988 Jan;254(1 Pt 2):H67-71 [3337261] Am J Physiol. 1988 Jul;255(1 Pt 2):H70-6 [3394828] Am J Physiol. 1966 Apr;210(4):801-6 [4286041] Am J Physiol. 1970 Feb;218(2):530-5 [5412470] J Physiol. 1970 Dec;211(2):445-60 [5501009] Proc Soc Exp Biol Med. 1972 Jul;140(3):820-4 [4261065] Pharmacol Rev. 1975 Mar;27(01):3-134 [166393] Am J Physiol. 1977 May;232(5):C165-73 [324293] Blood Vessels. 1977;14(5):261-76 [871531] J Gen Physiol. 1977 Aug;70(2):129-48 [894254] Am J Physiol. 1978 Apr;234(4):H404-11 [645879] Am J Physiol. 1979 Jul;237(1):C75-80 [464044] Am J Physiol. 1980 Aug;239(2):H199-205 [7406056] Am J Physiol. 1981 Aug;241(2):H129-33 [7270700] Fed Proc. 1981 Dec;40(14):2862-5 [7308496] Headache. 1984 Mar;24(2):55-8 [6715160] Microvasc Res. 1984 Sep;28(2):143-58 [6150420] Circ Res. 1985 Feb;56(2):231-41 [2578900] Am J Physiol. 1985 Mar;248(3 Pt 2):H419-23 [2579588] Hypertension. 1985 May-Jun;7(3 Pt 2):I25-30 [3997233] Br J Pharmacol. 1988 Jun;94(2):423-36 [3395784] J Cardiovasc Pharmacol. 1988 Jul;12(1):37-41 [2459532] J Cardiovasc Pharmacol. 1988;12 Suppl 6:S16-20 [2468899] Am J Physiol. 1989 Sep;257(3 Pt 2):H799-803 [2675632] Am J Physiol. 1967 Jun;212(6):1405-15 [4952132] Am J Physiol. 1990 Apr;258(4 Pt 2):H1138-43 [2109940] Am J Physiol. 1990 Jun;258(6 Pt 2):H1829-34 [2360673] J Gen Physiol. 1964 May;47:965-74 [14155438] Am J Physiol. 1986 Dec;251(6 Pt 2):H1276-82 [3789180] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rapid improvement in the chemical pathology of congenital erythropoietic porphyria with treatment with superactivated charcoal. AN - 80307645; 2084460 AB - Non-absorbable sorbents that bind porphyrins in the gastrointestinal tract may be useful in the treatment of porphyrias whose manifestations result from porphyrin excess. To test this, we assessed the effect of oral charcoal on porphyrin economy in a patient with a probable congenital erythropoietic porphyria. Treatment with a superactivated charcoal (Super Char), 25 g three times daily, was associated with a precipitous drop in erythrocyte porphyrin (from 21.4 +/- 2.9 [SD] to 7.4 +/- 0.4 nmole/ml; p less than 0.025) and plasma porphyrin (from 1.56 +/- 0.24 to 0.70 +/- 0.08 nmole/ml; p less than 0.01). Urinary porphyrin excretion appeared to rise, from 103 +/- 45 to 160 +/- 30 mumole/d, but the change was not statistically significant. Constipation appeared to limit compliance with the charcoal regimen by the end of the study period. Nonetheless, superactivated charcoal may be a useful therapy in this disfiguring porphyria. JF - Methods and findings in experimental and clinical pharmacology AU - Tishler, P V AU - Winston, S H AD - Brockton/West Roxbury Veterans Administration Medical Center, MA. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 645 EP - 648 VL - 12 IS - 9 SN - 0379-0355, 0379-0355 KW - Porphyrins KW - 0 KW - Charcoal KW - 16291-96-6 KW - Index Medicus KW - Humans KW - Constipation -- chemically induced KW - Adolescent KW - Male KW - Skin Diseases -- drug therapy KW - Porphyrias -- congenital KW - Porphyrins -- urine KW - Charcoal -- therapeutic use KW - Porphyrins -- blood KW - Porphyrias -- drug therapy KW - Skin Diseases -- congenital KW - Charcoal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80307645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.atitle=Rapid+improvement+in+the+chemical+pathology+of+congenital+erythropoietic+porphyria+with+treatment+with+superactivated+charcoal.&rft.au=Tishler%2C+P+V%3BWinston%2C+S+H&rft.aulast=Tishler&rft.aufirst=P&rft.date=1990-11-01&rft.volume=12&rft.issue=9&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.issn=03790355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-16 N1 - Date created - 1991-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity of cis-diamminedichloroplatinum (II) (cisplatin) in the frog, Rana pipiens. AN - 80298974; 2079554 AB - The toxicity of the anti-cancer drug cis-diamminedichloroplatinum (II) (cisplatin), at 2 to 40 mg per kg, was studied in the frog, Rana pipiens. The LD50 for the drug was approximately 17 mg per kg. Major non-nervous system toxicity occurred in the kidney. Renal failure was manifested as anasarca and increasing blood urea nitrogen (BUN). Histopathological changes included acute tubular necrosis and tubular dilatation, which were more severe at higher doses. Interstitial fibrosis occurred after prolonged survival after a single dose. Ultrastructurally, there was increased electron-dense material in tubular cells, but no specific changes in mitochondria or nuclear structures were seen. Gastro-intestinal toxicity was less severe than in other species and was more prominent at higher doses. Pathological changes consisted of epithelial nuclear atypia and apoptosis. By electron microscopy, there was increased separation of cell borders, depletion of chylomicrons and mucin granules and increases in electron-dense material. Again no specific mitochondrial or nuclear changes were seen. Relatively slight changes were seen in the liver, consisting of altered distribution of rough endoplasmic reticulum and dispersion of nuclear chromatin. Minimal pathology was demonstrated in the haematopoietic system or in the gonads. Thus toxicity of cisplatin in the frog is similar to that seen in mammals, including rodents and man. JF - Journal of comparative pathology AU - Blisard, K S AU - Harrington, D A AD - Research Service, Veterans' Administration Medical Center, Albuquerque, NM 87108. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 387 EP - 398 VL - 103 IS - 4 SN - 0021-9975, 0021-9975 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Rana pipiens KW - Animals KW - Liver -- pathology KW - Kidney -- pathology KW - Dose-Response Relationship, Drug KW - Testis -- pathology KW - Ovary -- drug effects KW - Hematopoietic System -- pathology KW - Kidney -- drug effects KW - Hematopoietic System -- drug effects KW - Digestive System -- drug effects KW - Testis -- drug effects KW - Ovary -- pathology KW - Liver -- drug effects KW - Central Nervous System -- drug effects KW - Lethal Dose 50 KW - Digestive System -- pathology KW - Male KW - Female KW - Cisplatin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80298974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+comparative+pathology&rft.atitle=Toxicity+of+cis-diamminedichloroplatinum+%28II%29+%28cisplatin%29+in+the+frog%2C+Rana+pipiens.&rft.au=Blisard%2C+K+S%3BHarrington%2C+D+A&rft.aulast=Blisard&rft.aufirst=K&rft.date=1990-11-01&rft.volume=103&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Journal+of+comparative+pathology&rft.issn=00219975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-02 N1 - Date created - 1991-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mood changes in substance abuse patients as a result of therapy. AN - 80252035; 2286691 AB - A sample of 57 substance abuse patients who were participating in a broad residential treatment program were evaluated for changes in negative affect. The Profile of Mood States (POMS) was administered once a week for 4 weeks. The 4-week changes on five of the six mood scales were significantly positive after treatment. The Interpersonal Style Inventory (ISI), completed at the beginning of the program, provided a mean scale score profile. Stylistically, patients were low in interpersonal involvement and distinctly below average in level of socialization (expedient, cynical, and hostile). In addition, patients could be characterized as anxious and dysphoric, impulsive, and dependent as judged by the norm sample. JF - Journal of clinical psychology AU - Lorr, J A AU - Lorr, M AU - Devlin, P AD - Veterans Administration Medical Center, Washington, DC. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 912 EP - 915 VL - 46 IS - 6 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Personality Tests KW - Humans KW - Interpersonal Relations KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Dependency (Psychology) KW - Socialization KW - Male KW - Female KW - Hospitalization KW - Psychotherapy KW - Depressive Disorder -- psychology KW - Veterans -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80252035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Mood+changes+in+substance+abuse+patients+as+a+result+of+therapy.&rft.au=Lorr%2C+J+A%3BLorr%2C+M%3BDevlin%2C+P&rft.aulast=Lorr&rft.aufirst=J&rft.date=1990-11-01&rft.volume=46&rft.issue=6&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tardive dyskinesia. AN - 80175611; 1979705 AB - Tardive dyskinesia is a potentially irreversible syndrome of involuntary hyperkinetic movements that occur in predisposed persons receiving extended neuroleptic (antipsychotic) drug therapy. It is usually characterized by choreoathetoid dyskinesias in the orofacial, limb, and truncal regions, but subtypes of this syndrome may include tardive dystonia and tardive akathisia. Although the mechanisms underlying the pathogenesis and pathophysiology of this disorder are unproven, altered dopaminergic functions will likely play a role in any explanation of it. Tardive dyskinesia develops in 20% of neuroleptic-treated patients, but high-risk groups such as the elderly have substantially higher rates. Risk factors include age, female sex, affective disorders, and probably those without psychotic diagnoses, including patients receiving drugs with antidopaminergic activity for nausea or gastrointestinal dysfunction for extended periods. Total drug exposure is positively correlated with tardive dyskinesia risk. Management strategies include a careful evaluation of both the psychiatric and neurologic states, a broad differential diagnosis, and adjustment of neuroleptic agents to the lowest effective dose that controls psychosis and minimizes motor side effects. No drug therapy is uniformly safe and effective for treating this disorder. A favorable long-term outcome of improvement or resolution correlates with younger age, early detection, lower drug exposure, and duration of follow-up. JF - The Western journal of medicine AU - Casey, D E AD - Psychiatry Service, Veterans Administration Medical Center, Portland, OR 97207. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 535 EP - 541 VL - 153 IS - 5 SN - 0093-0415, 0093-0415 KW - Antipsychotic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Diagnosis, Differential KW - Risk Factors KW - Humans KW - Prognosis KW - Movement Disorders -- diagnosis KW - Child KW - Dyskinesia, Drug-Induced -- therapy KW - Dyskinesia, Drug-Induced -- prevention & control KW - Dyskinesia, Drug-Induced -- epidemiology KW - Dyskinesia, Drug-Induced -- diagnosis KW - Dyskinesia, Drug-Induced -- etiology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80175611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Western+journal+of+medicine&rft.atitle=Tardive+dyskinesia.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1990-11-01&rft.volume=153&rft.issue=5&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=The+Western+journal+of+medicine&rft.issn=00930415&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-30 N1 - Date created - 1991-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1989;99 Suppl:S47-53 [2682732] J Clin Psychopharmacol. 1988 Aug;8(4 Suppl):31S-37S [2906068] Am J Psychiatry. 1982 Mar;139(3):341-3 [6120656] Arch Gen Psychiatry. 1982 Apr;39(4):473-81 [6121548] Arch Gen Psychiatry. 1982 Apr;39(4):486-7 [6121550] Neurology. 1982 Dec;32(12):1335-46 [6128697] Arch Gen Psychiatry. 1982 Jul;39(7):803-16 [6131655] Ann Neurol. 1983 Apr;13(4):402-11 [6838174] Psychol Med. 1983 Feb;13(1):71-81 [6133298] Br J Psychiatry. 1983 Jun;142:579-83 [6882980] Arch Gen Psychiatry. 1983 Oct;40(10):1113-7 [6138011] Can Psychiatr Assoc J. 1972 Feb;17(1):69-70 [5023942] Arch Gen Psychiatry. 1974 Mar;30(3):341-3 [4813137] Psychopharmacologia. 1974 Jan 9;34(1):21-35 [4593518] Psychopharmacology (Berl). 1977 Aug 31;54(1):1-8 [410053] Arch Gen Psychiatry. 1979 May;36(5):585-90 [35116] Br J Psychiatry. 1979 Dec;135:500-4 [43754] Arch Gen Psychiatry. 1980 Dec;37(12):1368-73 [6108750] Acta Psychiatr Scand Suppl. 1981;291:71-87 [6941630] Psychiatry Res. 1981 Jun;4(3):327-31 [6115438] Clin Neuropharmacol. 1983;6(3):207-22 [6138148] Am J Psychiatry. 1984 Jan;141(1):20-3 [6140865] Psychopharmacol Bull. 1984 Winter;20(1):22-6 [6718647] Psychopharmacol Bull. 1984 Summer;20(3):387-9 [6473637] J Clin Psychiatry. 1985 Apr;46(4 Pt 2):42-7 [2858480] Psychopharmacology Suppl. 1985;2:88-97 [2860664] Arch Gen Psychiatry. 1985 Sep;42(9):874-8 [2864031] Biol Psychiatry. 1987 Apr;22(4):427-39 [2882787] Psychopharmacol Ser. 1988;5:74-93 [2901085] Encephale. 1988 Sep;14 Spec No:221-6 [2905650] Acta Psychiatr Scand. 1964;40:10-27 [14217630] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incidence of cerebral hemorrhage after treatment with tissue plasminogen activator or streptokinase following embolic stroke in rabbits [corrected]. AN - 80117024; 2122552 AB - We studied thrombolysis in an animal model of embolic stroke to determine the safety of tissue plasminogen activator and streptokinase. We occluded the middle cerebral arteries of 137 rabbits with radiolabeled blood clots and administered tissue plasminogen activator (n = 49), streptokinase (n = 40), or saline (n = 48) at various times after embolization. We assessed the rate of thrombolysis and cerebral hemorrhage 24 hours later. Both drugs were very effective in producing thrombolysis. Compared with saline, streptokinase caused a significant increase in the rate of cerebral hemorrhage (p less than 0.05), but tissue plasminogen activator did not. We conclude that thrombolytic therapy for acute stroke should be safer with tissue plasminogen activator than with streptokinase. JF - Stroke AU - Lyden, P D AU - Madden, K P AU - Clark, W M AU - Sasse, K C AU - Zivin, J A AD - Department of Neurology, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1589 EP - 1593 VL - 21 IS - 11 SN - 0039-2499, 0039-2499 KW - Streptokinase KW - EC 3.4.- KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Animals KW - Risk Factors KW - Disease Models, Animal KW - Rabbits KW - Intracranial Embolism and Thrombosis -- physiopathology KW - Male KW - Tissue Plasminogen Activator -- therapeutic use KW - Cerebral Hemorrhage -- physiopathology KW - Streptokinase -- adverse effects KW - Cerebrovascular Disorders -- drug therapy KW - Tissue Plasminogen Activator -- adverse effects KW - Streptokinase -- therapeutic use KW - Cerebral Hemorrhage -- etiology KW - Thrombolytic Therapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80117024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Incidence+of+cerebral+hemorrhage+after+treatment+with+tissue+plasminogen+activator+or+streptokinase+following+embolic+stroke+in+rabbits+%5Bcorrected%5D.&rft.au=Lyden%2C+P+D%3BMadden%2C+K+P%3BClark%2C+W+M%3BSasse%2C+K+C%3BZivin%2C+J+A&rft.aulast=Lyden&rft.aufirst=P&rft.date=1990-11-01&rft.volume=21&rft.issue=11&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-24 N1 - Date created - 1990-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Stroke 1991 Feb;22(2):285 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thyrotoxicosis induced by topical iodine application. AN - 80116197; 2241453 AB - We describe an elderly man who was admitted with congestive cardiac failure and found to have thyrotoxicosis. He did not have goiter, and he had normal radioiodine uptake in his neck. Serum iodine levels were elevated, explaining the lack of increase in radioiodine uptake in the thyroid gland. He had multiple pressure sores, which were treated with povidone-iodine (Betadine) soaks. Biochemical data were consistent with Graves' disease unmasked by topical iodine application. Povidone-iodine soaks are commonly used in decubitus ulcer care and warrant special attention in patients with preexisting thyroid disorders. We have reviewed the literature on this unusual complication. JF - Archives of internal medicine AU - Shetty, K R AU - Duthie, E H AD - Section of Geriatrics and Gerontology, Zablocki Veterans Administration Medical Center, Milwaukee. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 2400 EP - 2401 VL - 150 IS - 11 SN - 0003-9926, 0003-9926 KW - Povidone-Iodine KW - 25655-41-8 KW - Abridged Index Medicus KW - Index Medicus KW - Graves Disease -- complications KW - Humans KW - Heart Failure -- chemically induced KW - Aged KW - Male KW - Administration, Topical KW - Povidone-Iodine -- administration & dosage KW - Povidone-Iodine -- therapeutic use KW - Povidone-Iodine -- adverse effects KW - Thyrotoxicosis -- chemically induced KW - Pressure Ulcer -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80116197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Thyrotoxicosis+induced+by+topical+iodine+application.&rft.au=Shetty%2C+K+R%3BDuthie%2C+E+H&rft.aulast=Shetty&rft.aufirst=K&rft.date=1990-11-01&rft.volume=150&rft.issue=11&rft.spage=2400&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-26 N1 - Date created - 1990-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gastroesophageal reflux and sclerotherapy strictures. AN - 80110603; 2240856 AB - The development of esophageal stricture is common following endoscopic variceal sclerotherapy (EVS). Gastroesophageal reflux may be at least partly responsible. Twelve randomly selected male patients underwent chronic EVS for the management of bleeding esophageal varices. Six patients developed strictures during or after EVS, six did not. There were no significant differences between stricture and nonstricture patients during 24 hour esophageal pH monitoring. Three of the six stricture patients and four of the six nonstricture patients had an abnormal amount of reflux. Gastroesophageal reflux occurs frequently in patients undergoing EVS, and it is not likely to play a major role in EVS stricture formation. JF - The American surgeon AU - Waring, J P AU - Talbert, G A AU - Austin, J AU - Sanowski, R A AD - Department of Internal Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 662 EP - 664 VL - 56 IS - 11 SN - 0003-1348, 0003-1348 KW - Sclerosing Solutions KW - 0 KW - Sodium Tetradecyl Sulfate KW - Q1SUG5KBD6 KW - Index Medicus KW - Evaluation Studies as Topic KW - Drug Administration Schedule KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Monitoring, Physiologic KW - Male KW - Gastrointestinal Hemorrhage -- etiology KW - Esophageal Stenosis -- chemically induced KW - Gastroesophageal Reflux -- complications KW - Esophageal and Gastric Varices -- complications KW - Sclerosing Solutions -- adverse effects KW - Sodium Tetradecyl Sulfate -- adverse effects KW - Sodium Tetradecyl Sulfate -- administration & dosage KW - Gastrointestinal Hemorrhage -- drug therapy KW - Esophageal and Gastric Varices -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80110603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+surgeon&rft.atitle=Gastroesophageal+reflux+and+sclerotherapy+strictures.&rft.au=Waring%2C+J+P%3BTalbert%2C+G+A%3BAustin%2C+J%3BSanowski%2C+R+A&rft.aulast=Waring&rft.aufirst=J&rft.date=1990-11-01&rft.volume=56&rft.issue=11&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=The+American+surgeon&rft.issn=00031348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-21 N1 - Date created - 1990-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes. AN - 80099869; 2233279 AB - Effects of protein kinase C (PKC) inhibitors and "down-regulation" on insulin and PMA-stimulated 2-deoxyglucose transport were determined in isolated rat adipocytes or BC3H-1 myocytes. In both model systems, H-7, sangivamycin, and staurosporine, inhibitors of the catalytic domain of PKC, each effectively blocked insulin and PMA-stimulated hexose uptake at similar concentrations. In the myocytes, staurosporine completely blocked the insulin effect retained post-chronic phorbol myristate acetate (PMA)-induced "down-regulation." These findings indicate (1) that chronic pretreatment with PMA may not lead to a complete loss of PKC activity in the myocyte, and (2) that PKC is involved in insulin-stimulated hexose transport in both isolated rat adipocytes and BC3H-1 myocytes. JF - Metabolism: clinical and experimental AU - Standaert, M L AU - Buckley, D J AU - Ishizuka, T AU - Hoffman, J M AU - Cooper, D R AU - Pollet, R J AU - Farese, R V AD - Veterans' Administration Hospital, Tampa, FL. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1170 EP - 1179 VL - 39 IS - 11 SN - 0026-0495, 0026-0495 KW - Alkaloids KW - 0 KW - Hexoses KW - Insulin KW - Isoquinolines KW - Piperazines KW - Pyrimidine Nucleosides KW - sangivamycin KW - 18417-89-5 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Deoxyglucose KW - 9G2MP84A8W KW - Protein Kinase C KW - EC 2.7.11.13 KW - Staurosporine KW - H88EPA0A3N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Pyrimidine Nucleosides -- pharmacology KW - Cell Separation KW - Piperazines -- pharmacology KW - Biological Transport -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Isoquinolines -- pharmacology KW - Alkaloids -- pharmacology KW - Deoxyglucose -- pharmacokinetics KW - Cell Line KW - Male KW - Hexoses -- pharmacokinetics KW - Muscles -- cytology KW - Protein Kinase C -- antagonists & inhibitors KW - Adipose Tissue -- cytology KW - Muscles -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Adipose Tissue -- enzymology KW - Insulin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80099869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Protein+kinase+C+inhibitors+block+insulin+and+PMA-stimulated+hexose+transport+in+isolated+rat+adipocytes+and+BC3H-1+myocytes.&rft.au=Standaert%2C+M+L%3BBuckley%2C+D+J%3BIshizuka%2C+T%3BHoffman%2C+J+M%3BCooper%2C+D+R%3BPollet%2C+R+J%3BFarese%2C+R+V&rft.aulast=Standaert&rft.aufirst=M&rft.date=1990-11-01&rft.volume=39&rft.issue=11&rft.spage=1170&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Hymenoptera venom study. III: Safety of venom immunotherapy. AN - 80089442; 2229842 AB - One thousand four hundred ten (44%) of the 3236 subjects in the Hymenoptera venom study accepted venom immunotherapy (VIT). Time to maintenance averaged 95 days, and the largest number achieved maintenance (147 subjects, 10.4%) at day 56. Ninety-two percent of the treated subjects achieved maintenance, and 84% continued therapy, most subjects (91%) until the study was terminated. One hundred seventy-one subjects (12%) experienced 327 treatment systemic reactions (Srs). The incidence of pruritus and angioedema/urticaria was similar with mild, moderate, or severe SRs. The SR severity did not correlate with the severity of the most recent sting before entry into the Hymenoptera-venom study, the most severe historical sting SR, the most severe SR during venom skin tests, the total dose of venom, the degree of skin test reactivity, or the lowest concentration yielding a positive skin test. Most SRs occurred between 1 and 50 micrograms and at maintenance; honeybee or wasp venoms were most likely to produce SR. This study, the largest of its kind with the use of standardized extracts, demonstrates (1) that there was good compliance, (2) that various historical and diagnostic criteria did not predict SRs to VIT, (3) that SRs to VIT were most likely to occur between 1 and 50 micrograms and at maintenance, (4) that honeybee or wasp venoms were most likely to produce an SR, and (5) that VIT is relatively safe. JF - The Journal of allergy and clinical immunology AU - Lockey, R F AU - Turkeltaub, P C AU - Olive, E S AU - Hubbard, J M AU - Baird-Warren, I A AU - Bukantz, S C AD - Department of Medicine, University of South Florida College of Medicine, James A. Haley Veterans Administration Hospital, Tampa 33612. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 775 EP - 780 VL - 86 IS - 5 SN - 0091-6749, 0091-6749 KW - Wasp Venoms KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Skin Tests KW - Humans KW - Dose-Response Relationship, Immunologic KW - Chi-Square Distribution KW - Wasp Venoms -- immunology KW - Desensitization, Immunologic KW - Insect Bites and Stings -- therapy KW - Hymenoptera -- immunology KW - Wasp Venoms -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80089442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=The+Hymenoptera+venom+study.+III%3A+Safety+of+venom+immunotherapy.&rft.au=Lockey%2C+R+F%3BTurkeltaub%2C+P+C%3BOlive%2C+E+S%3BHubbard%2C+J+M%3BBaird-Warren%2C+I+A%3BBukantz%2C+S+C&rft.aulast=Lockey&rft.aufirst=R&rft.date=1990-11-01&rft.volume=86&rft.issue=5&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-14 N1 - Date created - 1990-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic injury induced by bile salts: correlation between biochemical and morphological events. AN - 80080310; 2227821 AB - Continuous intravenous infusion of taurochenodeoxycholate at a rate of 0.4 mumol.min-1.100 gm-1 for only 30 min in rats caused threefold to tenfold greater release of proteins (alkaline phosphatase, lactate dehydrogenase and albumin) into bile in comparison with animals infused with tauroursodeoxycholate at much higher rates (1.8 mumol.min-1.100 gm-1) for 2 hr. The simultaneous infusion of tauroursodeoxycholate and taurochenodeoxycholate (0.6 and 0.4 mumol.min-1.100 gm-1, respectively) for 2 hr prevented the marked biochemical changes in the bile induced by taurochenodeoxycholate for 15 to 60 min exhibited significantly more necrotic hepatocytes, especially in zone 1, in comparison with animals infused with tauroursodeoxycholate or a combination of taurochenodeoxycholate and tauroursodeoxycholate. A good correlation was observed between biochemical and morphological indices of bile acid-induced hepatocyte injury. These data suggest that (a) primary events induced by the acute infusion of toxic bile salts responsible for cholestasis include zone 1 hepatocellular necrosis and (b) this can be prevented by the simultaneous infusion of tauroursodeoxycholate. JF - Hepatology (Baltimore, Md.) AU - Schmucker, D L AU - Ohta, M AU - Kanai, S AU - Sato, Y AU - Kitani, K AD - Cell Biology and Aging Section, Veterans Administration Medical Center, University of California, San Francisco. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1216 EP - 1221 VL - 12 IS - 5 SN - 0270-9139, 0270-9139 KW - Bile Acids and Salts KW - 0 KW - Proteins KW - Taurochenodeoxycholic Acid KW - 516-35-8 KW - Taurocholic Acid KW - 5E090O0G3Z KW - tauroursodeoxycholic acid KW - 60EUX8MN5X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Bile -- physiology KW - Animals KW - Necrosis KW - Bile -- metabolism KW - Taurochenodeoxycholic Acid -- pharmacology KW - Proteins -- metabolism KW - Male KW - Taurocholic Acid -- pharmacology KW - Bile -- drug effects KW - Bile Acids and Salts -- pharmacology KW - Liver -- pathology KW - Liver -- drug effects KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80080310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Hepatic+injury+induced+by+bile+salts%3A+correlation+between+biochemical+and+morphological+events.&rft.au=Schmucker%2C+D+L%3BOhta%2C+M%3BKanai%2C+S%3BSato%2C+Y%3BKitani%2C+K&rft.aulast=Schmucker&rft.aufirst=D&rft.date=1990-11-01&rft.volume=12&rft.issue=5&rft.spage=1216&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-19 N1 - Date created - 1990-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats. AN - 80078048; 1977650 AB - To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats infused for 48 h with a 50% glucose solution. To preserve the effects of in vivo hyperglycemia during in vitro handling for islet isolation, our standard isolation procedure utilized buffers containing 16.8 mM glucose. Islets from infused rats released similar amounts of insulin in low or high glucose during first incubations at 37 degrees C (92.4 +/- 7.0 ng.10 islets-1.45 min-1 at 2.8 mM, 84.4 +/- 4.1 ng.10 islets-1.45 min-1 at 16.8 mM) in contrast with control (uninfused) islets (18.6 +/- 2.8 ng.10 islets-1.45 min-1 at 2.8 mM and 109.8 +/- 8.0 ng.10 islets-1.45 min-1 at 16.8 mM glucose) (P less than 0.01). Secretion by islets of glucose-infused rats was lower during 60-min second incubations at 28 mM glucose than in first incubations of the same islets in low glucose (P less than 0.01). This phenomenon is comparable to the paradoxical hypersecretion observed during the first 10-15 min of exposure of glucose-infused pancreas to low-glucose perfusions. Paradoxical secretion in low glucose waned rapidly, so that during second incubations at 37 degrees C, little immunoreactive insulin release occurred at 2.8 mM glucose, despite the persistence of two additional lesions. The glucose-insulin dose-response curves in second incubations showed a leftward shift for glucose-infused islets, with two- to threefold higher secretion at 5.6-8.4 mM glucose than control islets. This is termed sensitization to glucose.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Diabetes AU - Timmers, K I AU - Powell, A M AU - Voyles, N R AU - Solomon, D AU - Wilkins, S D AU - Bhathena, S AU - Recant, L AD - Diabetes Research Laboratory, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1436 EP - 1444 VL - 39 IS - 11 SN - 0012-1797, 0012-1797 KW - Glycerides KW - 0 KW - Insulin KW - Keto Acids KW - Glyceraldehyde KW - 367-47-5 KW - Somatostatin KW - 51110-01-1 KW - Mannoheptulose KW - 654-29-5 KW - alpha-ketoisocaproic acid KW - 816-66-0 KW - Glucagon KW - 9007-92-5 KW - Tolbutamide KW - 982XCM1FOI KW - monoolein KW - C4YAD5F5G6 KW - Verapamil KW - CJ0O37KU29 KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Somatostatin -- analysis KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Tolbutamide -- pharmacology KW - Temperature KW - Mannoheptulose -- pharmacology KW - Keto Acids -- pharmacology KW - Verapamil -- pharmacology KW - Glycerides -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Drug Hypersensitivity -- etiology KW - Calcium -- pharmacokinetics KW - Glucagon -- analysis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Glyceraldehyde -- pharmacology KW - Male KW - Insulin -- analysis KW - Glucose -- pharmacology KW - Insulin -- blood KW - Islets of Langerhans -- drug effects KW - Islets of Langerhans -- metabolism KW - Islets of Langerhans -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80078048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Multiple+alterations+in+insulin+responses+to+glucose+in+islets+from+48-h+glucose-infused+nondiabetic+rats.&rft.au=Timmers%2C+K+I%3BPowell%2C+A+M%3BVoyles%2C+N+R%3BSolomon%2C+D%3BWilkins%2C+S+D%3BBhathena%2C+S%3BRecant%2C+L&rft.aulast=Timmers&rft.aufirst=K&rft.date=1990-11-01&rft.volume=39&rft.issue=11&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multicenter comparison of once- and twice-daily isradipine to hydrochlorothiazide for the treatment of hypertension in elderly patients. AN - 80077917; 2146060 AB - After 8 weeks of isradipine, a twice-a-day dihydropyridine calcium channel blocker, 49% of elderly patients showed a complete response (sitting diastolic blood pressure less than or equal to 85 mm Hg) and 36% showed a partial response (sitting diastolic blood pressure decrease greater than or equal to 10 mm Hg) for an 85% total response rate. Hydrochlorothiazide gave a complete response in 36% of the patients and a partial response in 33%, for a 69% total response rate (p less than 0.0046). Because elderly subjects have reduced clearance for many drugs, we determined how those who responded to twice-a-day administration would respond to once-a-day administration. After 4 weeks of isradipine administered once a day, 54% of the patients showed a complete or partial response, whereas 38% of the patients who were changed to placebo showed a response. In contrast, 82% of patients receiving hydrochlorothiazide once a day showed a response, whereas 60% of patients who were changed to placebo showed a response. These data indicate that the standard formulation of isradipine was not effective when administered once a day. JF - Clinical pharmacology and therapeutics AU - Holtzman, J L AU - Abrams, A AU - Cutler, R AU - Hamilton, B AU - Kirkendall, W M AU - Neri, G AU - Stein, G H AU - Matthews, K P AD - Department of Medicine and Pharmacology, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 590 EP - 597 VL - 48 IS - 5 SN - 0009-9236, 0009-9236 KW - Antihypertensive Agents KW - 0 KW - Pyridines KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Sodium KW - 9NEZ333N27 KW - Isradipine KW - YO1UK1S598 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Sodium -- blood KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Hydrochlorothiazide -- administration & dosage KW - Hypertension -- physiopathology KW - Pyridines -- administration & dosage KW - Antihypertensive Agents -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Pyridines -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Hydrochlorothiazide -- therapeutic use KW - Pyridines -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80077917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Multicenter+comparison+of+once-+and+twice-daily+isradipine+to+hydrochlorothiazide+for+the+treatment+of+hypertension+in+elderly+patients.&rft.au=Holtzman%2C+J+L%3BAbrams%2C+A%3BCutler%2C+R%3BHamilton%2C+B%3BKirkendall%2C+W+M%3BNeri%2C+G%3BStein%2C+G+H%3BMatthews%2C+K+P&rft.aulast=Holtzman&rft.aufirst=J&rft.date=1990-11-01&rft.volume=48&rft.issue=5&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-24 N1 - Date created - 1990-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pemoline-associated hepatic injury. AN - 80028833; 2210262 AB - Among 100 cases of hepatic injury attributed to the administration of pemoline, 43 had sufficient accompanying information to permit analysis. All but two patients were less than 20 years old, and 80% were less than 12 years old. Males predominated the study. Injury appeared as early as 1 week or as late as greater than 1 year of taking the drug. The injury was uniformly hepatocellular as judged by the high values for aminotransferases and by death in massive necrosis in one patient. Mechanism was judged to be idiosyncratic, and the idiosyncrasy was probably metabolic rather than immunologic. JF - Gastroenterology AU - Nehra, A AU - Mullick, F AU - Ishak, K G AU - Zimmerman, H J AD - Veterans Administration Medical Center, Washington, D.C. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 1517 EP - 1519 VL - 99 IS - 5 SN - 0016-5085, 0016-5085 KW - Pemoline KW - 7GAQ2332NK KW - Transaminases KW - EC 2.6.1.- KW - Abridged Index Medicus KW - Index Medicus KW - Transaminases -- blood KW - Humans KW - Adult KW - Middle Aged KW - Liver Diseases -- enzymology KW - Child KW - Adolescent KW - Male KW - Child, Preschool KW - Pemoline -- adverse effects KW - Pemoline -- administration & dosage KW - Chemical and Drug Induced Liver Injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80028833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Pemoline-associated+hepatic+injury.&rft.au=Nehra%2C+A%3BMullick%2C+F%3BIshak%2C+K+G%3BZimmerman%2C+H+J&rft.aulast=Nehra&rft.aufirst=A&rft.date=1990-11-01&rft.volume=99&rft.issue=5&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-21 N1 - Date created - 1990-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incidence of Behavior Problems Among Children of Vietnam War Veterans AN - 754885642; 13427430 AB - Vietnam combat veterans with post-traumatic stress disorder (PTSD) were compared to non-combat Vietnam era veterans without PTSD on their perceptions of their children's social and emotional functioning. A total of 107 veterans completed a parent's behavior checklist on their 191 children. The results indicated that fathers with PTSD perceived their children as exhibiting a substantially greater degree of dysfunctional social and emotional behavior. The types of dysfunctional behaviors were a function of the child's age and sex; however, children of PTSD fathers were generally rated as significantly more likely to exhibit an inadequate level of self-control resulting in various externalizing problem behaviors such as aggression, hyperactivity and delinquency. Further, these children were perceived as having difficulty establishing and maintaining friendships. The findings support the notion that a father's anxiety disorder, such as PTSD, may be related to his children's social and emotional functioning. JF - School Psychology International AU - Parsons, John AU - Kehle, Thomas J AU - Owen, Steve V AD - Veterans Administration, Providence, Rhode Island, USA Y1 - 1990/11// PY - 1990 DA - Nov 1990 SP - 253 EP - 259 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 4 SN - 0143-0343, 0143-0343 KW - Health & Safety Science Abstracts KW - Age KW - posttraumatic stress disorder KW - Children KW - aggressive behavior KW - war KW - Vietnam KW - schools KW - Behavior KW - Perception KW - delinquency KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754885642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=School+Psychology+International&rft.atitle=Incidence+of+Behavior+Problems+Among+Children+of+Vietnam+War+Veterans&rft.au=Parsons%2C+John%3BKehle%2C+Thomas+J%3BOwen%2C+Steve+V&rft.aulast=Parsons&rft.aufirst=John&rft.date=1990-11-01&rft.volume=11&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=School+Psychology+International&rft.issn=01430343&rft_id=info:doi/10.1177%2F0143034390114002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Behavior; schools; posttraumatic stress disorder; delinquency; Perception; aggressive behavior; Children; war; Vietnam DO - http://dx.doi.org/10.1177/0143034390114002 ER - TY - JOUR T1 - Alternate methods for the determination of atrial capture threshold utilizing the telemetered intracardiac electrogram. AN - 85264336; pmid-1701540 AB - Periodic determination of pacemaker capture threshold is important to ensure appropriate pacemaker function. During dual chamber pacing, it is sometimes difficult to identify evidence of atrial depolarization on surface electrocardiography (ECG), and this can interfere with the ability to ascertain atrial capture. We describe new methods for determining atrial capture threshold using a standard telemetered endocardial atrial electrogram (AEGM). For the first method, the atrial output is decremented until loss of atrial capture is demonstrated by the appearance of native P wave activity on the AEGM. The atrial capture threshold can then be accurately determined as the point at which a stepwise increase in atrial output results in extinction of the native P wave activity. The second method uses the direct visualization of the AEGM recorded between the ring electrode and pacemaker generator during unipolar (lead tip electrode) pacing. This requires the presence of a bipolar lead. Using this method of recording, it is possible to identify a signal after the atrial stimulus artifact during atrial capture, which disappears with loss of capture. This signal is consistent with a paced "evoked atrial potential" and allows verification of atrial capture. After validating the methods in two sets of test patients with clearly identifiable atrial depolarization on surface ECG, one method was successfully applied to a patient in whom atrial depolarization could not be reliably ascertained on surface ECG. These methods promise to be useful in selected patients in whom confirmation of atrial capture would otherwise be difficult. JF - Pacing and Clinical Electrophysiology AU - Feuer, J M AU - Florio, J AU - Shandling, A H AD - Department of Cardiology, Long Beach Veterans Administration Medical Center, CA 90822. PY - 1990 SP - 1254 EP - 1260 VL - 13 IS - 10 SN - 0147-8389, 0147-8389 KW - Cardiac Pacing, Artificial KW - Evoked Potentials KW - Electrocardiography KW - Human KW - Animal KW - Heart Atrium KW - Middle Age KW - Support, Non-U.S. Gov't KW - Female KW - Male KW - Pacemaker, Artificial KW - Telemetry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85264336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Alternate+methods+for+the+determination+of+atrial+capture+threshold+utilizing+the+telemetered+intracardiac+electrogram.&rft.au=Feuer%2C+J+M%3BFlorio%2C+J%3BShandling%2C+A+H&rft.aulast=Feuer&rft.aufirst=J&rft.date=1990-10-01&rft.volume=13&rft.issue=10&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Data management without data managers: an effective standardized system of otolaryngologic operative reporting. AN - 85191571; pmid-2215047 JF - The Laryngoscope AU - Toomey, J M AU - Vaughan, C W AU - Zeitels, S M AD - Section of Otolaryngology, Boston Veterans Administration Medical Center, Boston, MA 02130. PY - 1990 SP - 1122 EP - 1126 VL - 100 IS - 10 Pt 1 SN - 0023-852X, 0023-852X KW - Software KW - Data Collection KW - Otolaryngology KW - Clinical Protocols KW - Hospital Information Systems KW - Database Management Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85191571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Data+management+without+data+managers%3A+an+effective+standardized+system+of+otolaryngologic+operative+reporting.&rft.au=Toomey%2C+J+M%3BVaughan%2C+C+W%3BZeitels%2C+S+M&rft.aulast=Toomey&rft.aufirst=J&rft.date=1990-10-01&rft.volume=100&rft.issue=10+Pt+1&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Silver sulfadiazine and hydrocortisone cream 1% in the management of phenol matricectomy. AN - 80205488; 2269924 AB - The phenol matricectomy is one of the most common procedures performed in the podiatrist's office. Since a chemical burn is produced, correct care of the wound is essential. The authors studied the use of silver sulfadiazine, hydrocortisone cream, and a mixture of the two, on wounds resulting from phenol matricectomy procedures. The study shows that when silver sulfadiazine and hydrocortisone are used in combination, some of the usual sequelae seen with phenol matricectomies are markedly reduced and wound healing progresses at a more rapid rate with less complications. JF - Journal of the American Podiatric Medical Association AU - Altman, M I AU - Suleskey, C AU - Delisle, R AU - DeVelasco, M AD - Podiatric Section, Veterans Administration Medical Center, Albuquerque, NM 87108. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 545 EP - 547 VL - 80 IS - 10 SN - 8750-7315, 8750-7315 KW - Anti-Inflammatory Agents KW - 0 KW - Ointments KW - Phenols KW - Silver Sulfadiazine KW - W46JY43EJR KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Drug Therapy, Combination KW - Wound Healing -- drug effects KW - Humans KW - Administration, Topical KW - Phenols -- adverse effects KW - Silver Sulfadiazine -- administration & dosage KW - Burns, Chemical -- drug therapy KW - Phenols -- therapeutic use KW - Silver Sulfadiazine -- therapeutic use KW - Anti-Inflammatory Agents -- therapeutic use KW - Anti-Inflammatory Agents -- administration & dosage KW - Nail Diseases -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80205488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Silver+sulfadiazine+and+hydrocortisone+cream+1%25+in+the+management+of+phenol+matricectomy.&rft.au=Altman%2C+M+I%3BSuleskey%2C+C%3BDelisle%2C+R%3BDeVelasco%2C+M&rft.aulast=Altman&rft.aufirst=M&rft.date=1990-10-01&rft.volume=80&rft.issue=10&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The clinical significance of lithium-nonsteroidal anti-inflammatory drug interactions. AN - 80168332; 2258452 AB - There is conclusive evidence that nonsteroidal anti-inflammatory drugs can increase serum lithium levels, diminish renal lithium clearance, and possibly induce lithium toxicity. Such an interaction has occurred in patients with normal renal function. The effect on serum lithium levels varies greatly among different nonsteroidal anti-inflammatory drugs, indomethacin seeming most potent. On the other hand, there is no convincing evidence that sulindac and aspirin affect serum lithium levels to a clinically significant degree. Ibuprofen and naproxen can significantly increase serum lithium levels, but there is marked interindividual variation. Patients receiving nonsteroidal anti-inflammatory drugs must have their serum lithium levels checked every 4-5 days until the extent of drug interaction is assessed. A reduction in lithium dosage may be needed in some cases. JF - Journal of clinical psychopharmacology AU - Ragheb, M AD - Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 350 EP - 354 VL - 10 IS - 5 SN - 0271-0749, 0271-0749 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Drug Interactions KW - Humans KW - Metabolic Clearance Rate -- physiology KW - Kidney -- drug effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Lithium -- administration & dosage KW - Depressive Disorder -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- administration & dosage KW - Lithium -- adverse effects KW - Lithium -- pharmacokinetics KW - Depressive Disorder -- blood KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80168332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=The+clinical+significance+of+lithium-nonsteroidal+anti-inflammatory+drug+interactions.&rft.au=Ragheb%2C+M&rft.aulast=Ragheb&rft.aufirst=M&rft.date=1990-10-01&rft.volume=10&rft.issue=5&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-28 N1 - Date created - 1991-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potentiation of gamma-aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: receptor specificity. AN - 80164651; 2175016 AB - A large body of electrophysiological data has supported the hypothesis that an important role of norepinephrine in the central nervous system is to modulate the actions of other transmitter systems, particularly those utilizing the amino acid neurotransmitters. Noradrenergic potentiation of inhibitory responses, induced by locally-applied or synaptically-released gamma-aminobutyric acid (GABA) on cerebellar Purkinje neurons, has been observed by a number of investigators, who have suggested that activation of beta-adrenergic receptors plays a critical role in mediating this modulatory effect of norepinephrine (NE). Two postsynaptic receptors for GABA, termed A and B, have been identified and both subtypes have been found in the cerebellum of the rat. The purposes of this investigation were first to identify the subtype(s) of GABA receptor responsible for mediating the inhibitory effects of locally-applied GABA in the cerebellar cortex and second to identify which subtype of GABA receptor is modulated by a beta-adrenergic input. Inhibitory responses of cerebellar Purkinje neurons, in urethane-anesthetized rats, to iontophoretic or pressure-applied isoguvacine, a selective GABAA agonist, to baclofen, a GABAB agonist or to GABA itself, were examined before, during and after local application of isoproterenol or norepinephrine. Isoguvacine, but not baclofen, induced consistent and dose-dependent inhibition of the firing of Purkinje cells. At ejection currents that had no effect on spontaneous firing rate, iontophoretically-applied isoproterenol potentiated isoguvacine-induced inhibition. These data suggest that GABAA, rather than GABAB receptors, mediate GABA-induced inhibitions of cerebellar Purkinje neurons. Moreover, it appears that the modulation of GABA function by beta adrenergic agonists involves an interaction between a beta-adrenergic input and the GABAA receptor complex. JF - Neuropharmacology AU - Parfitt, K D AU - Hoffer, B J AU - Bickford-Wimer, P C AD - Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 909 EP - 916 VL - 29 IS - 10 SN - 0028-3908, 0028-3908 KW - Isonicotinic Acids KW - 0 KW - Receptors, GABA-A KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Baclofen KW - H789N3FKE8 KW - Isoproterenol KW - L628TT009W KW - isoguvacine KW - YTF580771Y KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Purkinje Cells -- drug effects KW - Neurons -- drug effects KW - Neurons -- physiology KW - Action Potentials -- drug effects KW - Drug Synergism KW - Male KW - Baclofen -- pharmacology KW - Purkinje Cells -- physiology KW - Isonicotinic Acids -- pharmacology KW - Receptors, GABA-A -- physiology KW - gamma-Aminobutyric Acid -- pharmacology KW - Cerebellar Cortex -- drug effects KW - Cerebellar Cortex -- physiology KW - Receptors, GABA-A -- drug effects KW - Isoproterenol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80164651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Potentiation+of+gamma-aminobutyric+acid-mediated+inhibition+by+isoproterenol+in+the+cerebellar+cortex%3A+receptor+specificity.&rft.au=Parfitt%2C+K+D%3BHoffer%2C+B+J%3BBickford-Wimer%2C+P+C&rft.aulast=Parfitt&rft.aufirst=K&rft.date=1990-10-01&rft.volume=29&rft.issue=10&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-24 N1 - Date created - 1991-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preventing NSAID-induced ulcers: the use of misoprostol. AN - 80102790; 2122334 JF - The Nurse practitioner AU - Lynn, M M AU - Holdcroft, C AD - Denver Veterans Administration Medical Center. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 38 EP - 9, 42 VL - 15 IS - 10 SN - 0361-1817, 0361-1817 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anti-Ulcer Agents KW - Misoprostol KW - 0E43V0BB57 KW - Alprostadil KW - F5TD010360 KW - Index Medicus KW - Nursing KW - Humans KW - Alprostadil -- adverse effects KW - Anti-Ulcer Agents -- adverse effects KW - Alprostadil -- therapeutic use KW - Alprostadil -- analogs & derivatives KW - Peptic Ulcer -- prevention & control KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Anti-Ulcer Agents -- therapeutic use KW - Peptic Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80102790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Preventing+NSAID-induced+ulcers%3A+the+use+of+misoprostol.&rft.au=Lynn%2C+M+M%3BHoldcroft%2C+C&rft.aulast=Lynn&rft.aufirst=M&rft.date=1990-10-01&rft.volume=15&rft.issue=10&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-14 N1 - Date created - 1990-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amantadine hydrochloride: current and new uses. AN - 80087706; 2146341 JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - de Roin, S AU - Winters, S AD - Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 322 EP - 325 VL - 22 IS - 5 SN - 0888-0395, 0888-0395 KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - Nursing KW - Influenza, Human -- prevention & control KW - Humans KW - Multiple Sclerosis -- drug therapy KW - Parkinson Disease -- drug therapy KW - Amantadine -- pharmacokinetics KW - Amantadine -- therapeutic use KW - Amantadine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80087706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Amantadine+hydrochloride%3A+current+and+new+uses.&rft.au=de+Roin%2C+S%3BWinters%2C+S&rft.aulast=de+Roin&rft.aufirst=S&rft.date=1990-10-01&rft.volume=22&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-19 N1 - Date created - 1990-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Neurosci Nurs. 1991 Apr;23(2):80 [1831476] J Neurosci Nurs. 1990 Dec;22(6):338 [2148761] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The incidence of serious hemodynamic changes in physically-limited patients following oral dipyridamole challenge before thallium-201 scintigraphy. AN - 80077236; 2225669 AB - Dipyridamole has liberalized referrals for stress TI-201 chloride (thallium) studies at the Iowa City Veterans Administration Medical Center. Seventy-five percent of referrals now receive dipyridamole and, unlike patients who tolerate conventional exercise testing, these patients are often quite debilitated. Therefore, the hemodynamic consequences of dipyridamole were reviewed in 120 consecutive, physically-limited patients referred for thallium scintigraphy following an average oral dose of 5.4 mg/kg. Each patient's blood pressure was measured every 5 minutes for 1 hour after dipyridamole and compared with several clinical factors to determine if blood pressure change was predictable. In all patients, blood pressure changed from 136 +/- 21/83 +/- 15 (mean +/- 1 SD) to 117 +/- 25/72 +/- 15 following dipyridamole administration. One hundred nine of the 120 patients had a blood pressure decline from 137 +/- 21/82 +/- 12 to 113 +/- 21/70 +/- 13. Of the 109, 43% (N = 47) had a systolic blood pressure decline greater than 20 mmHg, 16% (n = 18) greater than 40 mmHg, and 13% (n = 14) greater than 50 mmHg. Thirteen percent (n = 14) required emergent reversal of the dipyridamole with aminophylline. Significant hypotension is relatively common but generally unpredictable after oral dipyridamole. Therefore, patient eligibility criteria should be carefully considered; strict hemodynamic monitoring must be routine in the usual patient undergoing thallium scintigraphy after oral dipyridamole challenge. JF - Clinical nuclear medicine AU - Kahn, D AU - Argenyi, E A AU - Berbaum, K AU - Rezai, K AD - Radiology Department, Veterans Administration Hospital, Iowa City, Iowa. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 678 EP - 682 VL - 15 IS - 10 SN - 0363-9762, 0363-9762 KW - Thallium Radioisotopes KW - 0 KW - Dipyridamole KW - 64ALC7F90C KW - Index Medicus KW - Exercise Test KW - Administration, Oral KW - Humans KW - Middle Aged KW - Monitoring, Physiologic KW - Male KW - Female KW - Radionuclide Imaging KW - Hypotension -- chemically induced KW - Hemodynamics -- drug effects KW - Dipyridamole -- adverse effects KW - Heart -- diagnostic imaging KW - Dipyridamole -- administration & dosage KW - Coronary Disease -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80077236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=The+incidence+of+serious+hemodynamic+changes+in+physically-limited+patients+following+oral+dipyridamole+challenge+before+thallium-201+scintigraphy.&rft.au=Kahn%2C+D%3BArgenyi%2C+E+A%3BBerbaum%2C+K%3BRezai%2C+K&rft.aulast=Kahn&rft.aufirst=D&rft.date=1990-10-01&rft.volume=15&rft.issue=10&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-27 N1 - Date created - 1990-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inactivation of chemotactic factor inactivator by cigarette smoke. A potential mechanism of modulating neutrophil recruitment to the lung. AN - 80064367; 2221580 AB - Activation of the complement system with generation of the potent neutrophil chemotactic factor C5a has been proposed to play a significant role in the neutrophil accumulation in the lungs of cigarette smokers. Chemotactic factor inactivator (CFI) can inhibit C5a-directed neutrophil chemotaxis by binding to the C5a cochemotaxin GcGlobulin (GcG), a vitamin-D-binding protein, and inhibiting the capacity of GcG to enhance the chemotactic activity of C5a. Because cigarette smoke can inhibit the function of some proteins, a loss of CFI functional activity induced by cigarette smoke would allow an increased capacity of GcG to augment C5a-directed neutrophil chemotaxis. In order to test this hypothesis, cigarette smoke was bubbled through a CFI solution, and the solution was evaluated for its ability to inhibit the chemotactic activity of C5a and GcG. Smoke-treated CFI inhibited only 36% of the C5a-GcG chemotactic activity. In contrast, a CFI solution treated with air inhibited 62% of the chemotactic activity (p less than 0.001). Consistent with these observations, smoke-treated CFI exhibited a decreased capacity to bind to GcG and a decreased capacity to inhibit the binding of C5a des Arg to GcG. CFI contained in the bronchial lavage fluids obtained from patients with chronic obstructive pulmonary disease secondary to cigarette smoking and asymptomatic smokers exhibited a decreased capacity to inhibit C5a-GcG neutrophil chemotaxis and to bind to GcG (p less than 0.05, both comparisons). Furthermore, smoke bubbled through normal bronchial lavage fluid decreased the capacity of CFI to bind to GcG.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Robbins, R A AU - Gossman, G L AU - Nelson, K J AU - Koyama, S AU - Thompson, A B AU - Rennard, S I AD - Research Service, Omaha Veterans Administration Medical Center. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 763 EP - 768 VL - 142 IS - 4 SN - 0003-0805, 0003-0805 KW - Chemotactic Factors KW - 0 KW - Complement C5a, des-Arginine KW - Vitamin D-Binding Protein KW - chemotactic factor inactivator KW - Complement C5a KW - 80295-54-1 KW - Aminopeptidases KW - EC 3.4.11.- KW - Abridged Index Medicus KW - Index Medicus KW - Complement C5a -- pharmacology KW - Bronchoalveolar Lavage Fluid -- metabolism KW - Neutrophils -- pathology KW - Drug Interactions KW - Complement C5a, des-Arginine -- metabolism KW - Chemotaxis, Leukocyte -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Movement -- physiology KW - In Vitro Techniques KW - Vitamin D-Binding Protein -- pharmacology KW - Neutrophils -- physiology KW - Chemotactic Factors -- antagonists & inhibitors KW - Smoking -- adverse effects KW - Chemotactic Factors -- metabolism KW - Lung -- pathology KW - Lung -- metabolism KW - Lung -- physiology KW - Chemotactic Factors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80064367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Inactivation+of+chemotactic+factor+inactivator+by+cigarette+smoke.+A+potential+mechanism+of+modulating+neutrophil+recruitment+to+the+lung.&rft.au=Robbins%2C+R+A%3BGossman%2C+G+L%3BNelson%2C+K+J%3BKoyama%2C+S%3BThompson%2C+A+B%3BRennard%2C+S+I&rft.aulast=Robbins&rft.aufirst=R&rft.date=1990-10-01&rft.volume=142&rft.issue=4&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-15 N1 - Date created - 1990-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of ulcer surgery at a Veterans Administration and University Hospital. AN - 80063398; 2221609 AB - We compared the patient populations and outcome of surgery for peptic ulcer disease in 81 patients at a Veterans Administration Hospital (OVAH) and 97 patients at an affiliated University Hospital (UNH). The surgeons and choice of operation were comparable at both facilities. Patients were similar with respect to severity of ulcer disease, percentage of elderly patients and distribution of comorbid conditions. There were significantly more female patients (45% vs 2%, P less than 0.05), patients less than 40 years old (22% vs 6%, P less than 0.05), and patients with gastric ulcers (27% vs 12%, P less than 0.05) at UNH. Alcoholism was more prevalent at OVAH (57% vs 22%, P less than 0.05). Postoperative morbidity and mortality rates were 27 per cent and 14 per cent at OVAH and 25 per cent and 16 per cent at UNH. These data suggest that quality of care for surgical therapy of ulcer disease at a VA Hospital is comparable to its tertiary care affiliate with a similar patient population. JF - The American surgeon AU - Nguyen, B T AU - Thompson, J S AU - Edney, J A AU - Rikkers, L F AD - Surgical Service Omaha Veterans Administration Medical Center, Nebraska. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 606 EP - 609 VL - 56 IS - 10 SN - 0003-1348, 0003-1348 KW - Index Medicus KW - Postoperative Complications KW - Aged, 80 and over KW - Humans KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Aged KW - Middle Aged KW - Alcoholism -- complications KW - Male KW - Female KW - Comorbidity KW - Nebraska -- epidemiology KW - Peptic Ulcer -- complications KW - Peptic Ulcer -- surgery KW - Hospitals, Veterans -- standards KW - Hospitals, University -- standards KW - Peptic Ulcer -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80063398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+surgeon&rft.atitle=Comparison+of+ulcer+surgery+at+a+Veterans+Administration+and+University+Hospital.&rft.au=Nguyen%2C+B+T%3BThompson%2C+J+S%3BEdney%2C+J+A%3BRikkers%2C+L+F&rft.aulast=Nguyen&rft.aufirst=B&rft.date=1990-10-01&rft.volume=56&rft.issue=10&rft.spage=606&rft.isbn=&rft.btitle=&rft.title=The+American+surgeon&rft.issn=00031348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-02 N1 - Date created - 1990-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of iodine on lymphocytic thyroiditis in the thymectomized buffalo rat. AN - 80001841; 2401228 AB - Excess iodine has been associated with an increased incidence of lymphocytic thyroiditis (LT) in the BB/W rat, obese strain chicken, and hamster. The spontaneous incidence of LT in the Buffalo (Buf) rat is increased by neonatal thymectomy. In the present study, the effect of combined thymectomy and excess iodine ingestion on the incidence of LT in Buf rats has been examined. Buf rats were thymectomized at 1 day of age and randomized at 4 weeks of age to receive either standard rat chow with tap water (controls), or standard rat chow with 0.05% iodine in the drinking water (iodine group) for 12 weeks. The serum was assayed for TSH, antithyroglobulin antibodies, and iodine. The thyroids were fixed in Bouin's solution and stained with hematoxylin and eosin, and the presence of thyroiditis was determined. Iodine increased the incidence of LT from 31% in the control group to 73% in the iodine-treated group (P less than 0.05). Serum TSH concentrations and levels of thyroglobulin antibodies were significantly higher in the iodine-treated rats, primarily due to the increased incidence of LT and subsequent iodine-induced hypothyroidism. These data suggest that iodine enhances the effect of neonatal thymectomy on LT in Buf rats and support the concept that iodine may play an important role in the expression of LT in predisposed animals. JF - Endocrinology AU - Allen, E M AU - Braverman, L E AD - Alvin C. York Veterans Administration Medical Center, Murfreesboro, Tennessee 37130. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 1613 EP - 1616 VL - 127 IS - 4 SN - 0013-7227, 0013-7227 KW - Autoantibodies KW - 0 KW - anti-thyroglobulin KW - Thyrotropin KW - 9002-71-5 KW - Thyroglobulin KW - 9010-34-8 KW - Iodine KW - 9679TC07X4 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Thyroglobulin -- antagonists & inhibitors KW - Thyrotropin -- blood KW - Autoantibodies -- blood KW - Rats, Inbred BUF KW - Iodine -- administration & dosage KW - Iodine -- blood KW - Thymectomy KW - Iodine -- toxicity KW - Thyroiditis, Autoimmune -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80001841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+effect+of+iodine+on+lymphocytic+thyroiditis+in+the+thymectomized+buffalo+rat.&rft.au=Allen%2C+E+M%3BBraverman%2C+L+E&rft.aulast=Allen&rft.aufirst=E&rft.date=1990-10-01&rft.volume=127&rft.issue=4&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-22 N1 - Date created - 1990-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Advantages of beta blockers versus antiarrhythmic agents and calcium antagonists in secondary prevention after myocardial infarction. AN - 80064627; 1699400 AB - Patients who have sustained greater than or equal to 1 myocardial infarcts are at high risk for sudden death or reinfarction; the risk is highest for those with lowest ventricular ejection fraction, continuing myocardial ischemia and asymptomatic high-density and complex premature ventricular contractions. At present, beta blockers when given prophylactically are the only agents that reduce the incidence of sudden death and reinfarction in survivors of myocardial infarction (MI) in the first 2 years. The beneficial effect was shown to correlate with a reduction in heart rate, the effect being absent or deleterious with beta blockers with marked sympathomimetic activity. The effects of beta blockers on ventricular fibrillation appeared to be dissociated from those on premature ventricular contractions. Trials with calcium antagonists indicate that these drugs had no effect or increased the mortality rate. The divergent effect of beta blockers and calcium antagonists is unexplained but may be due in part to a lack of bradycardiac effect of calcium antagonists; there were no differences in effect among different calcium antagonists. Data from trials involving class I antiarrhythmic agents indicate that agents acting by depression of cardiac conduction are either devoid of effect or produce a modest increase in mortality. Results of the Cardiac Arrhythmia Suppression Trial, employing the newer class I agents flecainide and encainide, were used to determine whether the suppression of premature ventricular contractions in the survivors of acute MI reduces mortality. Flecainide and encainide suppressed premature ventricular contractions greater than 80%, but resulted in an increased mortality rate undoubtedly due to a marked proarrhythmic effect. Whether these data can be extrapolated to all class I agents is uncertain. Preliminary data with class III antiarrhythmic agents suggest that these agents, especially amiodarone, similarly to beta blockers, have the potential to reduce mortality in survivors of MI. Evolving data suggest that in the secondary prevention of morbid events in the survivors of acute MI, the focus must shift away from antiarrhythmic agents that delay conduction and toward beta blockers and antifibrillatory actions resulting from a prolongation of refractoriness. JF - The American journal of cardiology AU - Singh, B N AD - Department of Cardiology, Wadsworth Veterans Administration Hospital, Los Angeles, California 90073. Y1 - 1990/09/25/ PY - 1990 DA - 1990 Sep 25 SP - 9C EP - 20C VL - 66 IS - 9 SN - 0002-9149, 0002-9149 KW - Adrenergic beta-Antagonists KW - 0 KW - Anti-Arrhythmia Agents KW - Calcium Channel Blockers KW - Amiodarone KW - N3RQ532IUT KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Randomized Controlled Trials as Topic KW - Heart Rate -- drug effects KW - Heart Conduction System -- drug effects KW - Humans KW - Death, Sudden KW - Circadian Rhythm -- drug effects KW - Amiodarone -- therapeutic use KW - Cardiac Complexes, Premature -- prevention & control KW - Pilot Projects KW - Time Factors KW - Recurrence KW - Adrenergic beta-Antagonists -- classification KW - Myocardial Infarction -- mortality KW - Anti-Arrhythmia Agents -- classification KW - Calcium Channel Blockers -- adverse effects KW - Myocardial Infarction -- prevention & control KW - Adrenergic beta-Antagonists -- therapeutic use KW - Myocardial Infarction -- physiopathology KW - Calcium Channel Blockers -- therapeutic use KW - Calcium Channel Blockers -- classification KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80064627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Advantages+of+beta+blockers+versus+antiarrhythmic+agents+and+calcium+antagonists+in+secondary+prevention+after+myocardial+infarction.&rft.au=Singh%2C+B+N&rft.aulast=Singh&rft.aufirst=B&rft.date=1990-09-25&rft.volume=66&rft.issue=9&rft.spage=9C&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-02 N1 - Date created - 1990-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An insertion in the human thyrotropin receptor critical for high affinity hormone binding. AN - 80012734; 2169649 AB - Thyrotropin (TSH), luteinizing hormone (LH), and chorionic gonadotropin (CG) are structurally related glycoprotein hormones, which bind to receptors that share a high degree of sequence similarity. However, comparison of the primary amino acid sequences of the TSH and LH-CG receptors reveals two unique insertions of 8 and 50 amino acids in the extracellular domain of the TSH receptor. The functional significance of these insertions were determined by site-directed mutagenesis. Deletion of the 50-amino acid tract (residues 317 to 366) had no effect on TSH binding or on TSH and thyroid-stimulating immunoglobulin (TSI) biological activities. In contrast, either deletion or substitution of the eight-amino acid region (residues 38 to 45) abolished these activities. This eight-amino acid tract near the amino terminus of the TSH receptor appears to be an important site of interaction for both TSH and TSI. JF - Science (New York, N.Y.) AU - Wadsworth, H L AU - Chazenbalk, G D AU - Nagayama, Y AU - Russo, D AU - Rapoport, B AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990/09/21/ PY - 1990 DA - 1990 Sep 21 SP - 1423 EP - 1425 VL - 249 IS - 4975 SN - 0036-8075, 0036-8075 KW - Oligonucleotide Probes KW - 0 KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Clone Cells KW - Animals KW - Chromosome Deletion KW - Base Sequence KW - Transfection KW - Humans KW - Molecular Sequence Data KW - Cyclic AMP -- metabolism KW - Mutation KW - Cell Line KW - Binding Sites KW - Receptors, Thyrotropin -- metabolism KW - Thyrotropin -- pharmacology KW - Thyrotropin -- metabolism KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80012734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=An+insertion+in+the+human+thyrotropin+receptor+critical+for+high+affinity+hormone+binding.&rft.au=Wadsworth%2C+H+L%3BChazenbalk%2C+G+D%3BNagayama%2C+Y%3BRusso%2C+D%3BRapoport%2C+B&rft.aulast=Wadsworth&rft.aufirst=H&rft.date=1990-09-21&rft.volume=249&rft.issue=4975&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-26 N1 - Date created - 1990-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia. AN - 80067417; 1699612 JF - Biological psychiatry AU - Lohr, J B AU - Kuczenski, R AU - Bracha, H S AU - Moir, M AU - Jeste, D V AD - Department of Psychiatry, San Diego Veterans Administration Medical Center, CA 92161. Y1 - 1990/09/15/ PY - 1990 DA - 1990 Sep 15 SP - 535 EP - 539 VL - 28 IS - 6 SN - 0006-3223, 0006-3223 KW - Antipsychotic Agents KW - 0 KW - Free Radicals KW - Lipid Peroxides KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Humans KW - Psychotic Disorders -- cerebrospinal fluid KW - Neurologic Examination KW - Aged KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Homovanillic Acid -- cerebrospinal fluid KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Adult KW - Middle Aged KW - 3,4-Dihydroxyphenylacetic Acid -- cerebrospinal fluid KW - Antipsychotic Agents -- adverse effects KW - Female KW - Male KW - Lipid Peroxides -- cerebrospinal fluid KW - Dyskinesia, Drug-Induced -- diagnosis KW - Lipid Peroxidation -- physiology KW - Dyskinesia, Drug-Induced -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80067417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Increased+indices+of+free+radical+activity+in+the+cerebrospinal+fluid+of+patients+with+tardive+dyskinesia.&rft.au=Lohr%2C+J+B%3BKuczenski%2C+R%3BBracha%2C+H+S%3BMoir%2C+M%3BJeste%2C+D+V&rft.aulast=Lohr&rft.aufirst=J&rft.date=1990-09-15&rft.volume=28&rft.issue=6&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-07 N1 - Date created - 1990-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hemispheric asymmetries in attentional control: implications for hand preference in sensorimotor tasks. AN - 85209562; pmid-2223046 AB - Liepmann (1908) proposed that handedness reflects the greater capacity of one hemisphere to learn the execution of skilled movements. Although asymmetries in motor control are an important basis for hand asymmetries, recent studies have suggested that handedness may be determined by multiple factors. In the present study, we examine how attentional asymmetries may contribute to hand preferences. Right-handed subjects participated in a reaction time task in which they were given preliminary information about where a target stimulus would occur (selective attention) or which hand to use for responding (selective intention). Our findings indicate that these processes influence each other reciprocally and favor a state of optimal attentional and intentional preparation of the right hand. We suggest that these hemispheric asymmetries in attentional control contribute to hand preferences in certain sensorimotor tasks. JF - Brain and Cognition AU - Verfaellie, M AU - Heilman, K M AD - Memory Disorders Research Center, Boston Veterans Administration Medical Center, Massachusetts 02130. PY - 1990 SP - 70 EP - 80 VL - 14 IS - 1 SN - 0278-2626, 0278-2626 KW - Set (Psychology) KW - Orientation KW - Arousal KW - Human KW - Adult KW - Neuropsychological Tests KW - Male KW - Reaction Time KW - Psychomotor Performance KW - Dominance, Cerebral KW - Laterality KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Hemispheric+asymmetries+in+attentional+control%3A+implications+for+hand+preference+in+sensorimotor+tasks.&rft.au=Verfaellie%2C+M%3BHeilman%2C+K+M&rft.aulast=Verfaellie&rft.aufirst=M&rft.date=1990-09-01&rft.volume=14&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Acetaminophen metabolism in recovering alcoholics. AN - 80321043; 2087153 AB - The mercapturic acid conjugate of acetaminophen has been proposed as an index of the toxic intermediate of acetaminophen metabolism which is responsible for the increased incidence of liver injury in alcoholics taking the drug. Previous studies which compared alcoholics with normal patients failed to show any significant difference in mercapturic acid production. We undertook a longitudinal study in recovering alcoholics to test the hypothesis that abstinence should lead to a decrease in acetaminophen-mercapturic acid excretion. The patients were given a 1500 mg dose of acetaminophen soon after they stopped drinking then again approximately 2 weeks later. Urine was collected for 24 h and assayed for mercapturic acid conjugate. There was no significant difference in mercapturic acid excretion when the two measurements were compared. If the toxic intermediate hypothesis is correct, either the effect of alcohol is prolonged, or additional factor other than alcohol exposure may influence mercapturic acid excretion. JF - Methods and findings in experimental and clinical pharmacology AU - Skinner, M H AU - Matano, R AU - Hazle, W AU - Blaschke, T F AD - Veterans Administration Hospital, Palo Alto, CA 94304. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 513 EP - 515 VL - 12 IS - 7 SN - 0379-0355, 0379-0355 KW - Acetaminophen KW - 362O9ITL9D KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Administration, Oral KW - Acetylcysteine -- urine KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Female KW - Alcoholism -- metabolism KW - Acetaminophen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80321043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.atitle=Acetaminophen+metabolism+in+recovering+alcoholics.&rft.au=Skinner%2C+M+H%3BMatano%2C+R%3BHazle%2C+W%3BBlaschke%2C+T+F&rft.aulast=Skinner&rft.aufirst=M&rft.date=1990-09-01&rft.volume=12&rft.issue=7&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.issn=03790355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-23 N1 - Date created - 1991-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Valproate potentiates and picrotoxin antagonizes the anxiolytic action of ethanol in a nonshock conflict task. AN - 80269709; 1981382 AB - The purpose of this study was to examine the effects of the indirect GABA agonist valproate and the indirect GABA antagonist picrotoxin on the anxiolytic (anti-conflict) activity of ethanol in a behavioral conflict task that does not employ electroshock. This task (negative contrast) quantifies how animals respond to an abrupt, unexpected reduction in reward. Treatment with valproate alone did not elevated depressed behavior engendered by abrupt reduction in reward. However, when administered together with a sub-effective dose of ethanol (0.5 g/kg), valproate (50-200 mg/kg) dose-dependently potentiated the anxiolytic action of ethanol. Picrotoxin (2 mg/kg) antagonized the anxiolytic effects of a larger dose of ethanol (1.0 g/kg) given alone, as well as the ability of valproate to enhance the anxiolytic effects of smaller dose of ethanol (0.5 g/kg). As such, these data support a role for GABA in mediating the anxiolytic activity of ethanol. JF - Neuropharmacology AU - Becker, H C AU - Anton, R F AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 837 EP - 843 VL - 29 IS - 9 SN - 0028-3908, 0028-3908 KW - Anti-Anxiety Agents KW - 0 KW - Picrotoxin KW - 124-87-8 KW - Ethanol KW - 3K9958V90M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Drug Synergism KW - Male KW - Valproic Acid -- pharmacology KW - Conflict (Psychology) KW - Ethanol -- pharmacology KW - Picrotoxin -- pharmacology KW - Ethanol -- antagonists & inhibitors KW - gamma-Aminobutyric Acid -- physiology KW - Anti-Anxiety Agents -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80269709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Valproate+potentiates+and+picrotoxin+antagonizes+the+anxiolytic+action+of+ethanol+in+a+nonshock+conflict+task.&rft.au=Becker%2C+H+C%3BAnton%2C+R+F&rft.aulast=Becker&rft.aufirst=H&rft.date=1990-09-01&rft.volume=29&rft.issue=9&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-09 N1 - Date created - 1991-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enzyme markers of contrast media-induced renal failure. AN - 80245393; 2283232 JF - Investigative radiology AU - Parvez, Z AU - Ramamurthy, S AU - Patel, N B AU - Moncada, R AD - Radiology Research Laboratory, Veterans Administration Hospital, Hines, Illinois. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - S133 EP - S134 VL - 25 Suppl 1 SN - 0020-9996, 0020-9996 KW - Biomarkers KW - 0 KW - Contrast Media KW - Enzymes KW - Diatrizoate KW - 117-96-4 KW - Iohexol KW - 4419T9MX03 KW - Index Medicus KW - Osmolar Concentration KW - Diatrizoate -- adverse effects KW - Iohexol -- adverse effects KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Contrast Media -- adverse effects KW - Acute Kidney Injury -- chemically induced KW - Kidney -- drug effects KW - Enzymes -- urine KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80245393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Enzyme+markers+of+contrast+media-induced+renal+failure.&rft.au=Parvez%2C+Z%3BRamamurthy%2C+S%3BPatel%2C+N+B%3BMoncada%2C+R&rft.aulast=Parvez&rft.aufirst=Z&rft.date=1990-09-01&rft.volume=25+Suppl+1&rft.issue=&rft.spage=S133&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-20 N1 - Date created - 1991-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dealing with the impaired supervisor. AN - 80205410; 10170657 AB - As professional impairment issues have gained increasing recognition, a multitude of resources have been established for dealing with them. The most common source of impairment is chemical dependence-especially involving alcohol. The PA working with an impaired supervisor should understand the disease process associated with chemical dependence, come to terms with his or her own personal views on impairment, and seek support from colleagues. Every state has some form of physician impairment mechanism. With increasing availability of support systems, the prospects are good for successful rehabilitation of impaired professionals. JF - Physician assistant (American Academy of Physician Assistants) AU - Mott, J S AD - Veterans Administration Medical Center, Loma Linda, CA. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 93 EP - 4, 99-101 VL - 14 IS - 9 SN - 8750-7544, 8750-7544 KW - Health administration KW - United States KW - Humans KW - Alcoholism -- prevention & control KW - Substance-Related Disorders -- prevention & control KW - Physician Assistants -- psychology KW - Interprofessional Relations KW - Professional Impairment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80205410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physician+assistant+%28American+Academy+of+Physician+Assistants%29&rft.atitle=Dealing+with+the+impaired+supervisor.&rft.au=Mott%2C+J+S&rft.aulast=Mott&rft.aufirst=J&rft.date=1990-09-01&rft.volume=14&rft.issue=9&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Physician+assistant+%28American+Academy+of+Physician+Assistants%29&rft.issn=87507544&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-21 N1 - Date created - 1991-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conditioned tolerance provides protection against ethanol lethality. AN - 80185774; 2263663 AB - To produce conditioned drug tolerance, mice were given twice daily injections of 3.5 g/kg of ethanol for four days and were tested on the fifth day in the same environment or in a novel environment. A range of doses of ethanol were utilized on the test day to assess lethality. The LD50 for ethanol was higher in mice tested in the environment previously associated with the administration of ethanol than in those tested in a novel environment. Therefore, conditioned tolerance can provide protection against ethanol lethality. JF - Pharmacology, biochemistry, and behavior AU - Melchior, C L AD - Brentwood Division Research, West Los Angeles Veterans Administration, CA 90073. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 205 EP - 206 VL - 37 IS - 1 SN - 0091-3057, 0091-3057 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Environment KW - Animals KW - Drug Tolerance -- physiology KW - Lethal Dose 50 KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Conditioning, Classical -- physiology KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80185774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Conditioned+tolerance+provides+protection+against+ethanol+lethality.&rft.au=Melchior%2C+C+L&rft.aulast=Melchior&rft.aufirst=C&rft.date=1990-09-01&rft.volume=37&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-01 N1 - Date created - 1991-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Primary hyperaldosteronism. AN - 80124412; 2240013 JF - The American journal of the medical sciences AU - Levi, M AD - Southwestern Internal Medicine Conference, Department of Internal Medicine, Dallas Veterans Administration Medical Center, Texas. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 189 EP - 202 VL - 300 IS - 3 SN - 0002-9629, 0002-9629 KW - Electrolytes KW - 0 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Aldosterone KW - 4964P6T9RB KW - Abridged Index Medicus KW - Index Medicus KW - Hypertension -- chemically induced KW - Humans KW - Desoxycorticosterone -- pharmacology KW - Kidney Tubules -- metabolism KW - Electrolytes -- metabolism KW - Aldosterone -- secretion KW - Hyperaldosteronism -- classification KW - Hyperaldosteronism -- therapy KW - Hyperaldosteronism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80124412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Primary+hyperaldosteronism.&rft.au=Levi%2C+M&rft.aulast=Levi&rft.aufirst=M&rft.date=1990-09-01&rft.volume=300&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A rationale for evaluation of byssinosis. AN - 80099047; 2234110 JF - North Carolina medical journal AU - Pratt, P C AD - Department of Pathology, Durham Veterans Administration Hospital. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 447 EP - 453 VL - 51 IS - 9 SN - 0029-2559, 0029-2559 KW - Index Medicus KW - Humans KW - Environmental Exposure KW - Chronic Disease KW - Prevalence KW - Lung Diseases, Obstructive -- etiology KW - Byssinosis -- diagnosis KW - Byssinosis -- epidemiology KW - Gossypium -- adverse effects KW - Lung Diseases, Obstructive -- diagnosis KW - Lung Diseases, Obstructive -- epidemiology KW - Byssinosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80099047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=North+Carolina+medical+journal&rft.atitle=A+rationale+for+evaluation+of+byssinosis.&rft.au=Pratt%2C+P+C&rft.aulast=Pratt&rft.aufirst=P&rft.date=1990-09-01&rft.volume=51&rft.issue=9&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=North+Carolina+medical+journal&rft.issn=00292559&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-19 N1 - Date created - 1990-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The MAC scale in a normal population: the meaning of "false positives". AN - 80097121; 2232800 AB - The MAC scale has been very successful in identifying alcoholics and, in studies of clinical populations, is often considered a test for predisposition to alcoholism. MacAndrew, however, holds that the MAC scale assesses a more general personality trait characterized by sociability, boldness, rebelliousness and pleasure seeking. The present study examines the distribution of MAC scale scores in a normal population and tests for correlates of high MAC scores other than alcohol-related problems (e.g., arrest history). The sample consisted of 1,117 men, participants in the Normative Aging Study (mean age = 61.6). As expected, heavier drinkers and problem drinkers reported significantly higher MAC scale scores than did lighter and nonproblem drinkers. However, arrestees without drinking problems had MAC scale scores nearly identical to those of problem drinkers without arrest histories (23.19 and 23.42, respectively). Further, 36% of the sample without problem drinking or arrest histories had MAC scale scores of 24 or above, the clinical indicator of alcoholism, and more than 32% of these had scores above 27. In the entire sample, of the 152 men who had MAC scores above 27, 71% had no problems, either with arrest or drinking. Results are interpreted as supporting MacAndrew's interpretation of the meaning of the MAC scale as a general personality measure rather than a specific alcoholism instrument. JF - Journal of studies on alcohol AU - Levenson, M R AU - Aldwin, C M AU - Butcher, J N AU - De Labry, L AU - Workman-Daniels, K AU - Bossé, R AD - Normative Aging Study, Veterans Administration Medical Center, Bedford, Massachusetts 01730. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 457 EP - 462 VL - 51 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Diagnosis, Differential KW - Aged, 80 and over KW - Adaptation, Psychological KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Aged KW - Middle Aged KW - Psychometrics KW - Male KW - Alcoholism -- diagnosis KW - MMPI KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80097121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=The+MAC+scale+in+a+normal+population%3A+the+meaning+of+%22false+positives%22.&rft.au=Levenson%2C+M+R%3BAldwin%2C+C+M%3BButcher%2C+J+N%3BDe+Labry%2C+L%3BWorkman-Daniels%2C+K%3BBoss%C3%A9%2C+R&rft.aulast=Levenson&rft.aufirst=M&rft.date=1990-09-01&rft.volume=51&rft.issue=5&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-06 N1 - Date created - 1990-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of paced respiration on anxiety reduction in a clinical population. AN - 80068602; 2223892 AB - The purpose of this study was to examine the effects of paced respiration on autonomic and self-report indices of affect within a clinical population. Thirty-six alcohol-dependent inpatients scoring high in trait anxiety were randomly assigned to either a pacing or attention control group. The paced subjects received 10 minutes of slow-breathing training during the first experimental session, while control subjects simply counted the pacing tones. In a second session, paced subjects were asked to breathe at the same lowered rate (10 cycles per minute) on their own, while the remaining subjects were instructed to relax. Prior to and following each session, self-ratings of tension level and state anxiety were collected. As expected, paced subjects evidenced greater reductions in self-rated tension, state anxiety, and skin conductance levels compared to the control subjects. It was concluded that respiratory pacing is an easily learned self-control strategy and potentially may be a useful therapeutic tool. JF - Biofeedback and self-regulation AU - Clark, M E AU - Hirschman, R AD - Veterans Administration Medical Center, Bay Pines, Florida. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 273 EP - 284 VL - 15 IS - 3 SN - 0363-3586, 0363-3586 KW - Index Medicus KW - Random Allocation KW - Humans KW - Adult KW - Middle Aged KW - Psychometrics KW - Alcoholism -- complications KW - Male KW - Biofeedback, Psychology KW - Respiration KW - Anxiety Disorders -- therapy KW - Anxiety Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80068602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biofeedback+and+self-regulation&rft.atitle=Effects+of+paced+respiration+on+anxiety+reduction+in+a+clinical+population.&rft.au=Clark%2C+M+E%3BHirschman%2C+R&rft.aulast=Clark&rft.aufirst=M&rft.date=1990-09-01&rft.volume=15&rft.issue=3&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Biofeedback+and+self-regulation&rft.issn=03633586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-24 N1 - Date created - 1990-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - EEG alpha activity and personality traits. AN - 80064981; 2222849 AB - Comparisons between EEG spectral power in the fast alpha (9-12 Hz) range and scores obtained on the Millon Clinical Personality Inventory (MCMI) were made in two populations of subjects. The first was a group of 60 individuals who reported no personal or family history of alcoholism. The second was a subgroup of 13 sons of alcoholics and 13 matched control subjects. In the first population, 30% of the subjects were classified as "high" alpha based on the criteria that their EEG in the 9-12 Hz range was over 75 microV2/octave in amplitude. Using this same criteria, 69% of the sons of alcoholics and 31% of their matched controls were also classified as "high" alpha. In both populations, subjects with high amplitude fast frequency EEG alpha activity in lead P4-O2 scored significantly higher on the Histrionic-Gregarious scale of the MCMI than subjects with low amplitude activity in this lead. These results are consistent with some previous studies showing a positive relationship between EEG alpha activity and extroverted personality traits. These results suggest that fast frequency alpha activity may be associated with some definable personality traits. JF - Alcohol (Fayetteville, N.Y.) AU - Wall, T L AU - Schuckit, M A AU - Mungas, D AU - Ehlers, C L AD - Department of Psychiatry, San Diego Veterans Administration Hospital, CA. PY - 1990 SP - 461 EP - 464 VL - 7 IS - 5 SN - 0741-8329, 0741-8329 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Personality KW - Alcoholism -- physiopathology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Alpha Rhythm UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80064981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=EEG+alpha+activity+and+personality+traits.&rft.au=Wall%2C+T+L%3BSchuckit%2C+M+A%3BMungas%2C+D%3BEhlers%2C+C+L&rft.aulast=Wall&rft.aufirst=T&rft.date=1990-09-01&rft.volume=7&rft.issue=5&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-06 N1 - Date created - 1990-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational distribution of inflammatory bowel disease among German employees. AN - 80023275; 2210450 AB - Previous reports have shown that both Crohn's disease and ulcerative colitis affect people in white collar occupations associated with higher income and higher social class more frequently than other groups in the population. This study sought to carry these analyses one step further and investigate the distribution of inflammatory bowel disease by individual occupations. The German social security statistics for 'rehabilitation' were used to assess the occupational distribution of Crohn's disease and ulcerative colitis. From 1982 to 1988, a total of 12,014 people were granted rehabilitation as a result of inflammatory bowel disease. Low male prevalence of inflammatory bowel disease was found among bricklayers, road construction workers, unskilled workers in brick and stone, unskilled labourers, and security personnel. Low rates were found among women employed in cleaning and maintenance, and in those without occupation. In contrast, a high male prevalence was found among instrument makers, electricians, bakers, and technical assistants. Among female employees, inflammatory bowel disease was significantly associated with sales representatives, office workers, health occupations, and hairdressers. These associations were found in the complete data for 1982-8 as well as in the separate data for the two half periods 1982-5 and 1986-8. Highly significant correlations between the occupational distribution of Crohn's disease and ulcerative colitis were found among both male and female employees. It seems that occupations involving work in the open air and physical exercise are protective, while being exposed to air conditioned artificial working conditions or extended and irregular shift working confer a risk of contracting inflammatory bowel disease. JF - Gut AU - Sonnenberg, A AD - Division of Gastroenterology, Veterans Administration Medical Center, Milwaukee, WI 53295. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 1037 EP - 1040 VL - 31 IS - 9 SN - 0017-5749, 0017-5749 KW - Abridged Index Medicus KW - Index Medicus KW - Work Schedule Tolerance KW - Sex Factors KW - Environment, Controlled KW - Risk Factors KW - Humans KW - Germany, West KW - Male KW - Female KW - Crohn Disease -- epidemiology KW - Crohn Disease -- rehabilitation KW - Occupational Diseases -- rehabilitation KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- classification KW - Colitis, Ulcerative -- rehabilitation KW - Colitis, Ulcerative -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80023275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Occupational+distribution+of+inflammatory+bowel+disease+among+German+employees.&rft.au=Sonnenberg%2C+A&rft.aulast=Sonnenberg&rft.aufirst=A&rft.date=1990-09-01&rft.volume=31&rft.issue=9&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=00175749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-01 N1 - Date created - 1990-11-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1969 May;56(5):847-57 [5782295] J Chronic Dis. 1971 Dec;24(12):743-73 [5146188] Scand J Gastroenterol. 1976;11(3):293-6 [1273504] Gut. 1984 Aug;25(8):886-99 [6086465] Am J Epidemiol. 1985 Jul;122(1):106-11 [3160234] Gut. 1985 Sep;26(9):968-74 [3896963] Dig Dis Sci. 1989 Nov;34(11):1720-9 [2582985] Dis Colon Rectum. 1986 Dec;29(12):854-61 [3792167] Gastroenterology. 1988 Jul;95(1):42-8 [3371623] BMJ. 1988 Oct 29;297(6656):1105-6 [3143445] Gut. 1988 Sep;29(9):1229-35 [3197997] Gut. 1989 Mar;30(3):367-70 [2707636] J Occup Med. 1986 Feb;28(2):87-90 [2936875] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lysis of fibrillar collagen by neutrophils in synovial fluid. A role for surface-bound immunoglobulins. AN - 80011077; 2169747 AB - Synovial fluids (SF) contain inhibitors capable of neutralizing the activity of proteases secreted by inflammatory cells and fibroblasts. To further define a potential role for SF polymorphonuclear neutrophils (PMN) in mediating joint destruction, peripheral blood PMN were suspended in SF and incubated with reconstituted collagen fibrils. Incubation of PMN-SF mixtures with collagen fibrils precoated with monomeric IgG resulted in significant lysis of the underlying fibrils relative to that seen with uncoated fibrils. Augmented fibril lysis by PMN-SF mixtures in which the PMN were activated with fluid-phase ligands such as phorbol myristate acetate or heat-aggregated IgG was not seen. Lysis of IgG-coated fibrils by PMN-SF was inhibited in the presence of EDTA or sodium azide. PMN-mediated resorption of fibrillar collagen occurred despite the presence of protease inhibitors in the SF at a concentration capable of neutralizing human neutrophil collagenase. These results suggest that the focal release and activation of human neutrophil collagenase during PMN stimulation by tissue-bound immunoglobulins may mediate the resorption of joint tissue collagens in rheumatoid arthritis, even in the presence of protease inhibitors. JF - Arthritis and rheumatism AU - Chatham, W W AU - Heck, L W AU - Blackburn, W D AD - Division of Clinical Immunology and Rheumatology, Birmingham Veterans Administration Hospital, AL 35233. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 1333 EP - 1339 VL - 33 IS - 9 SN - 0004-3591, 0004-3591 KW - Azides KW - 0 KW - Immunoglobulin G KW - Ligands KW - Collagen KW - 9007-34-5 KW - Sodium Azide KW - 968JJ8C9DV KW - Edetic Acid KW - 9G34HU7RV0 KW - Microbial Collagenase KW - EC 3.4.24.3 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Immunoglobulin G -- pharmacology KW - Azides -- pharmacology KW - Microbial Collagenase -- metabolism KW - Immunoglobulin G -- physiology KW - Edetic Acid -- pharmacology KW - Neutrophils -- immunology KW - Collagen -- metabolism KW - Synovial Fluid -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80011077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Lysis+of+fibrillar+collagen+by+neutrophils+in+synovial+fluid.+A+role+for+surface-bound+immunoglobulins.&rft.au=Chatham%2C+W+W%3BHeck%2C+L+W%3BBlackburn%2C+W+D&rft.aulast=Chatham&rft.aufirst=W&rft.date=1990-09-01&rft.volume=33&rft.issue=9&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-24 N1 - Date created - 1990-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of transport of nontransferrin-bound iron in basolateral and canalicular rat liver plasma membrane vesicles. AN - 80006929; 2401456 AB - Although most iron in plasma is bound to transferrin, recent evidence suggests that the nontransferrin-bound fraction contributes to hepatic iron loading and toxicity seen in iron-overload disorders. Our studies of isolated perfused rat liver previously demonstrated saturable uptake of nontransferrin-bound iron that continues despite hepatic iron overload. To further characterize the mechanism of transport of this form of iron, we measured binding of 55Fe-labeled ferrous ascorbate to rat liver plasma membrane vesicles under varying conditions. Binding of 5 mumol/L iron by both basolateral and canalicular membranes was time-dependent and linear for the first 5 sec. Initial rate of binding of ferrous ascorbate to basolateral membrane vesicles was temperature dependent and increased by calcium but, in contrast to the perfused rat liver, was not inhibited by other divalent cations. Binding velocities by basolateral membrane vesicles were saturable at increasing iron concentration (Km = 33 mumol/L, Vmax = 16 pmol/mg protein/sec). Ferrous iron binding by canalicular membrane vesicles was also temperature dependent, but initial association rates were not saturable over the concentration range studied (2 to 20 mumol/L). We conclude that nontransferrin-bound iron associates with basolateral liver plasma membrane vesicles by a saturable mechanism sensitive to temperature and calcium and consistent with a membrane carrier. Other divalent cations do not inhibit membrane association but may compete for a subsequent cytosolic binding site. JF - Hepatology (Baltimore, Md.) AU - Wright, T L AU - Lake, J R AD - Liver Center, Veterans Administration Medical Center San Francisco, California 94121. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 498 EP - 504 VL - 12 IS - 3 Pt 1 SN - 0270-9139, 0270-9139 KW - Iron Radioisotopes KW - 0 KW - Transferrin KW - Iron KW - E1UOL152H7 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Cell Fractionation -- methods KW - Dose-Response Relationship, Drug KW - Temperature KW - Biological Transport KW - Cell Membrane -- ultrastructure KW - Perfusion -- methods KW - Calcium -- metabolism KW - Rats KW - In Vitro Techniques KW - Microscopy, Electron KW - Cell Membrane -- metabolism KW - Liver -- ultrastructure KW - Liver -- metabolism KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80006929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Mechanisms+of+transport+of+nontransferrin-bound+iron+in+basolateral+and+canalicular+rat+liver+plasma+membrane+vesicles.&rft.au=Wright%2C+T+L%3BLake%2C+J+R&rft.aulast=Wright&rft.aufirst=T&rft.date=1990-09-01&rft.volume=12&rft.issue=3+Pt+1&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-24 N1 - Date created - 1990-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. AN - 80002599; 2205558 AB - The use of the Tsukamoto-French rat model of alcoholic liver disease facilitated pathological, physiological, biochemical and cell biological experiments that examined the validity of some of the existing hypotheses for pathogenesis of alcoholic liver necrosis and fibrosis. Results obtained to date strongly support the contribution of centrilobular hypoxia as a pathogenetic mechanism of alcoholic liver necrosis. The enhanced hepatic lipid peroxidation was not evident at the early stage of ethanol-induced liver necrosis but could be demonstrated at the late stage when the liver damage progressed to liver fibrosis. This suggests that the lipid peroxidation may not be an important mechanism of alcoholic liver necrosis but may be an initiation factor for liver fibrogenesis as recently proposed by others (88). The high-fat diet appears to have promoting effects on both induction of alcoholic liver necrosis and stimulation of liver fibrogenesis. The former may be related to the induction of MEOS by the high-fat diet and consequent centrilobular hypoxia caused by inadequately compensated hepatic overuse of oxygen. The latter can be mediated through sensitization of Ito cells by a high-fat diet. We propose that Kupffer cell-derived TGF beta is, at least in part, responsible for some of phenotypical changes of Ito cells associated with their activation. Our model provides maximal experimental control and induces the discrete stages of alcoholic liver injury that can be reproduced with its pathological evolution telescoped into a short time. Because of these features, replication of the experimental conditions in different laboratories is possible so that results can be validly compared through precise standardization of the experimental protocols. This model requires some training in implantation and maintenance of the gastric catheter. However, the training can be easily attained by anyone who has experience in animal surgery. Another requirement is the initial fund to acquire infusion devices and metabolism cages. Once this equipment is purchased, however, the maintenance cost is low. Even if the initial expenses are included, the cost per animal is relatively inexpensive when compared with the cost involved in the use of larger animals such as baboons or pigs. Since administration of diet and ethanol (or isocaloric glucose solution) is precisely controlled by infusion pumps, this system makes unnecessary the measurement of diet consumption that has to be done daily for each animal with other methods.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Tsukamoto, H AU - Gaal, K AU - French, S W AD - Hepatopancreatic Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 599 EP - 608 VL - 12 IS - 3 Pt 1 SN - 0270-9139, 0270-9139 KW - Dietary Fats KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Fibrosis -- etiology KW - Necrosis -- etiology KW - Disease Models, Animal KW - Lipid Peroxidation KW - Necrosis -- blood KW - Rats KW - Hypoxia -- complications KW - Ethanol -- adverse effects KW - Ethanol -- blood KW - Fibrosis -- blood KW - Dietary Fats -- adverse effects KW - Liver Cirrhosis, Alcoholic -- etiology KW - Liver Cirrhosis, Alcoholic -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80002599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Insights+into+the+pathogenesis+of+alcoholic+liver+necrosis+and+fibrosis%3A+status+report.&rft.au=Tsukamoto%2C+H%3BGaal%2C+K%3BFrench%2C+S+W&rft.aulast=Tsukamoto&rft.aufirst=H&rft.date=1990-09-01&rft.volume=12&rft.issue=3+Pt+1&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-24 N1 - Date created - 1990-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidermal growth factor accelerates renal repair in mercuric chloride nephrotoxicity. AN - 79988540; 2396670 AB - Repair and recovery of ischemic or nephrotoxic acute renal failure (ARF) are dependent upon renal tubule cell regeneration. Because epidermal growth factor (EGF) is a potent growth promoter to renal tubule cells, experiments were undertaken to assess the effects of exogenous administration of EGF during the recovery phase of HgCl2-induced ARF. Rats were administered HgCl2 (5 mg/kg sc), and [3H]thymidine incorporation into renal tissue and blood urea nitrogen (BUN) and serum creatinine concentrations were measured at various times after toxin administration. EGF (20 microgram) was administered subcutaneously 2 or 4 h after HgCl2 injection. Exogenous EGF resulted in greater levels of renal [3H]thymidine incorporation into renal proximal tubule cells compared with those observed in nontreated animals at several time points in the first 48 h after toxic injury. Morphometric analysis of histoautoradiograph sections of renal tissue demonstrated that greater than 96% of labeled cells were tubular in all examined sections. This EGF-related acceleration in DNA synthesis was associated with significantly lower peak BUN and serum creatinine levels, averaging 213 +/- 23 and 6.54 +/- 0.72 (SE) mg/dl, respectively, at 3 days in EGF-treated nephrotoxic rats compared with peak levels of 359 +/- 40 and 9.92 +/- 1.67 mg/dl (P less than 0.001, n = 7-16) at 5 days in non-EGF-treated nephrotoxic rats. EGF treatment also was associated with a return to near normal BUN and serum creatinine levels approximately 4 days earlier than that observed in non-EGF-treated animals. These findings demonstrate that exogenous EGF accelerates the repair process of the kidney after a severe toxic insult. JF - The American journal of physiology AU - Coimbra, T M AU - Cieslinski, D A AU - Humes, H D AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - F438 EP - F443 VL - 259 IS - 3 Pt 2 SN - 0002-9513, 0002-9513 KW - Mercuric Chloride KW - 53GH7MZT1R KW - Epidermal Growth Factor KW - 62229-50-9 KW - Creatinine KW - AYI8EX34EU KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cell Division -- drug effects KW - Blood Urea Nitrogen KW - Autoradiography KW - Creatinine -- blood KW - Male KW - Kidney -- metabolism KW - Kidney -- pathology KW - Acute Kidney Injury -- pathology KW - Acute Kidney Injury -- chemically induced KW - Epidermal Growth Factor -- pharmacology KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79988540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Epidermal+growth+factor+accelerates+renal+repair+in+mercuric+chloride+nephrotoxicity.&rft.au=Coimbra%2C+T+M%3BCieslinski%2C+D+A%3BHumes%2C+H+D&rft.aulast=Coimbra&rft.aufirst=T&rft.date=1990-09-01&rft.volume=259&rft.issue=3+Pt+2&rft.spage=F438&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice. AN - 79977002; 2394827 AB - Endotoxemia stimulates many physiologic responses including disturbances in lipid metabolism. We hypothesized that this lipemia may be part of a defensive mechanism by which the body combats the toxic effects of circulating endotoxin. We tested the effects of mixtures of endotoxin, lipoproteins, and lipoprotein-free plasma and determined the ability of varying concentrations of human very low density lipoproteins (VLDL) and chylomicrons, as well as low density lipoproteins (LDL) and high density lipoproteins (HDL), and of the synthetic lipid emulsion SOYACAL to prevent endotoxin-induced death in mice. This study demonstrates that the triglyceride-rich VLDL and chylomicrons, as well as cholesterol-rich LDL and HDL, and cholesterol-free SOYACAL can protect against endotoxin-induced death. Protection required small amounts of lipoprotein-free plasma, and depended on the incubation time and the concentration of lipoprotein lipid. Despite stringent techniques to prevent exogenous endotoxin contamination eight of ten duplicate VLDL preparations contained endotoxin (5,755 +/- 3,514 ng endotoxin/mg triglyceride, mean +/- SEM) making the isolation of endotoxin-free VLDL difficult. In contrast, simultaneous preparations of LDL and HDL were relatively free of endotoxin contamination (3 +/- 3 and 320 +/- 319 ng/mg total cholesterol, respectively), suggesting that the contamination of VLDL occurs in vivo and not during the isolation procedure. These observations suggest a possible role for increased triglyceride-rich lipoproteins in the host's defense against endotoxemia and infection. JF - The Journal of clinical investigation AU - Harris, H W AU - Grunfeld, C AU - Feingold, K R AU - Rapp, J H AD - Department of Surgery, San Francisco Veterans Administration Medical Center, California 94121. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 696 EP - 702 VL - 86 IS - 3 SN - 0021-9738, 0021-9738 KW - Chylomicrons KW - 0 KW - Emulsions KW - Endotoxins KW - Lipoproteins KW - Lipoproteins, VLDL KW - soyacal KW - Soybean Oil KW - 8001-22-7 KW - Abridged Index Medicus KW - Index Medicus KW - Soybean Oil -- pharmacology KW - Animals KW - Humans KW - Mice, Inbred C57BL KW - Lipoproteins -- analysis KW - Mice KW - Lipoproteins, VLDL -- pharmacology KW - Endotoxins -- analysis KW - Endotoxins -- toxicity KW - Chylomicrons -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79977002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Human+very+low+density+lipoproteins+and+chylomicrons+can+protect+against+endotoxin-induced+death+in+mice.&rft.au=Harris%2C+H+W%3BGrunfeld%2C+C%3BFeingold%2C+K+R%3BRapp%2C+J+H&rft.aulast=Harris&rft.aufirst=H&rft.date=1990-09-01&rft.volume=86&rft.issue=3&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Environ Microbiol. 1985 Jul;50(1):91-3 [3896144] Am J Physiol. 1985 Jun;248(6 Pt 1):E732-40 [3890559] Proc Natl Acad Sci U S A. 1986 Apr;83(8):2704-8 [3517876] J Infect Dis. 1986 Nov;154(5):784-91 [3095436] J Exp Med. 1987 Mar 1;165(3):657-63 [3819645] J Clin Invest. 1987 Jul;80(1):184-90 [3597772] J Clin Invest. 1988 Feb;81(2):601-5 [3339132] Metabolism. 1988 Sep;37(9):859-65 [3419323] J Lipid Res. 1989 Jan;30(1):39-49 [2493057] Endocrinology. 1989 May;124(5):2336-42 [2707158] Arch Surg. 1989 Jun;124(6):727-32 [2658919] J Biol Chem. 1989 Jun 25;264(18):10867-71 [2471708] Endocrinology. 1989 Jul;125(1):267-74 [2661207] J Clin Invest. 1955 Sep;34(9):1345-53 [13252080] J Exp Med. 1958 Nov 1;108(5):685-99 [13587851] Physiol Rev. 1960 Apr;40:245-79 [13850016] Ann N Y Acad Sci. 1966 Jun 30;133(2):644-62 [4164246] N Engl J Med. 1969 Nov 13;281(20):1081-6 [5824173] J Lab Clin Med. 1970 Jun;75(6):903-11 [5421075] J Infect Dis. 1972 Jan;125(1):54-60 [4400225] Metabolism. 1972 Sep;21(9):825-33 [4626894] Biochim Biophys Acta. 1973 Mar 16;298(2):145-57 [4578206] J Infect Dis. 1973 Jul;128:Suppl:197-201 [4578309] Gastroenterology. 1977 Jun;72(6):1268-70 [858472] Am J Clin Nutr. 1977 Aug;30(8):1311-20 [888782] Am J Pathol. 1978 Nov;93(2):526-618 [362943] Biochim Biophys Acta. 1978 Dec 4;514(1):69-82 [363151] J Clin Invest. 1978 Dec;62(6):1313-24 [372234] J Immunol. 1979 Mar;122(3):932-5 [376709] J Clin Invest. 1979 Nov;64(5):1516-24 [227936] Mol Biochem Parasitol. 1980 Oct;2(1):31-8 [7464858] J Clin Invest. 1981 Mar;67(3):827-37 [7204557] J Immunol. 1981 Apr;126(4):1575-80 [7204977] Arch Surg. 1982 Feb;117(2):144-7 [7034675] Microbiol Immunol. 1982;26(11):1017-34 [6220193] J Clin Pathol. 1983 Oct;36(10):1145-9 [6352744] J Lab Clin Med. 1984 Sep;104(3):321-30 [6088654] Rev Infect Dis. 1984 Jul-Aug;6(4):488-92 [6474009] Rev Infect Dis. 1984 Jul-Aug;6(4):493-6 [6206542] Clin Chem. 1986 Jan;32(1 Pt 1):142-5 [3940695] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute and subacute effects of injury on the canine alveolar septum. AN - 79976257; 2394148 AB - The effect of papain on the prevalence and distribution of alveolar macrophages, alveolar septal interstitial tissue gaps and epithelial cells in normal canine pulmonary alveoli was studied by light and electron microscopy. Serial sections of whole alveoli from control animals and from animals sacrificed 4 h, two weeks and one month after the instillation into one lung of crude papain in saline solution containing India ink as a marker were compared. In dogs, as in humans, there is normally a zonal distribution of alveolar macrophages and type 2 cells at alveolar junctional sites. We hypothesize that early alveolar septal injury takes place at these junctional sites, judging from concentration of alveolar macrophages and interstitial septal gaps at these sites following papain exposure, and also that septal repair activities are greatest at these sites, in view of the preponderance and high prevalence of type 2 cells occupying interstitial septal gaps in junctional zones. Consequently, the type 2 cell may play a role beyond that of merely replacing type 1 epithelial cells following alveolar septal injury. JF - Chest AU - Takaro, T AU - Chapman, W E AU - Burnette, R AU - Cordell, S AD - Research Service, Veterans Administration Medical Center, Asheville, NC 28805-2087. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 724 EP - 732 VL - 98 IS - 3 SN - 0012-3692, 0012-3692 KW - Papain KW - EC 3.4.22.2 KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Cell Nucleus -- ultrastructure KW - Dogs KW - Macrophages -- ultrastructure KW - Epithelium -- ultrastructure KW - Pulmonary Emphysema -- pathology KW - Pulmonary Alveoli -- ultrastructure KW - Pulmonary Emphysema -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79976257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Acute+and+subacute+effects+of+injury+on+the+canine+alveolar+septum.&rft.au=Takaro%2C+T%3BChapman%2C+W+E%3BBurnette%2C+R%3BCordell%2C+S&rft.aulast=Takaro&rft.aufirst=T&rft.date=1990-09-01&rft.volume=98&rft.issue=3&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-05 N1 - Date created - 1990-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention. AN - 79974884; 2203846 AB - Osteoporosis is a common complication of chronic glucocorticoid therapy, especially in older patients who already are at risk of having a reduced bone mass. Glucocorticoids cause bone loss by altering the bone remodeling sequence: bone resorption by osteoclasts is increased, and bone formation by osteoblasts is decreased. Serum levels of osteocalcin, a protein made by osteoblasts, are decreased with glucocorticoid therapy, further evidence of decreased osteoblast function. Glucocorticoids decrease calcium absorption by the gastrointestinal tract and increase renal calcium excretion. Several recent studies suggest that low-dose glucocorticoid therapy is not associated with bone loss. Calcium supplementation with vitamin D is recommended. Several short-term studies have shown prevention of glucocorticoid-induced bone loss with bisphosphonates, calcitonin, and progesterone. Long-term clinical trials should be undertaken to determine strategies to prevent this type of osteoporosis. JF - Journal of gerontology AU - Mitchell, D R AU - Lyles, K W AD - GRECC, Durham Veterans Administration Medical Center. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - M153 EP - M158 VL - 45 IS - 5 SN - 0022-1422, 0022-1422 KW - Glucocorticoids KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Bone Resorption KW - Humans KW - Aged KW - Osteoporosis -- prevention & control KW - Glucocorticoids -- adverse effects KW - Osteoporosis -- physiopathology KW - Osteoporosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79974884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gerontology&rft.atitle=Glucocorticoid-induced+osteoporosis%3A+mechanisms+for+bone+loss%3B+evaluation+of+strategies+for+prevention.&rft.au=Mitchell%2C+D+R%3BLyles%2C+K+W&rft.aulast=Mitchell&rft.aufirst=D&rft.date=1990-09-01&rft.volume=45&rft.issue=5&rft.spage=M153&rft.isbn=&rft.btitle=&rft.title=Journal+of+gerontology&rft.issn=00221422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-05 N1 - Date created - 1990-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Disruption of folate and vitamin B12 metabolism in aged rats following exposure to nitrous oxide. AN - 79970877; 2393136 AB - The ability of nitrous oxide (N2O) to disrupt folate and vitamin B12 metabolism was examined in young (2-month), middle-aged (12-month), and elderly (24-month) Fischer 344 rats. Abnormalities in folate metabolism were assessed in a noninvasive manner by measuring the urinary excretion of formic acid and formiminoglutamic acid (FIGLU), compounds that are elevated in the urine of mammals with a deficiency in folate. After a 6-h exposure to 60% N2O/40% O2, urinary formic acid excretion increased 3- to 25-fold the first day following N2O exposure and returned to background levels by the second day after exposure in all age groups. Urinary FIGLU excretion increased 100- to 300-fold in the first day following N2O exposure, with the highest FIGLU excretion rates found in the elderly rats and the lowest in the young rats. By the second day after N2O exposure, FIGLU excretion rates returned to baseline levels in all age groups. Plasma folate progressively decreased with increasing age, whereas no age-dependent changes were observed in red cell folate, liver folate, or plasma vitamin B12 levels. The elderly rats demonstrated the highest vitamin B12 content in the liver and the lowest vitamin B12 content in the kidney compared to the other age groups. Hepatic methionine synthase activities (measured 16-21 days after N2O exposure) were elevated in the elderly compared to the middle-aged or young rats, but methionine synthase activities in kidney and brain were not different among the three different age groups. It was concluded that in rats, aging per se only slightly influences the disruption of folate metabolism produced by exposure to N2O. JF - Anesthesiology AU - Koblin, D D AU - Tomerson, B W AU - Waldman, F M AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 506 EP - 512 VL - 73 IS - 3 SN - 0003-3022, 0003-3022 KW - Folic Acid KW - 935E97BOY8 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Kidney -- metabolism KW - Liver -- drug effects KW - Brain -- drug effects KW - Kidney -- drug effects KW - Liver -- metabolism KW - Brain -- metabolism KW - Male KW - Aging -- metabolism KW - Folic Acid -- metabolism KW - Nitrous Oxide -- toxicity KW - Folic Acid -- blood KW - Vitamin B 12 -- metabolism KW - Vitamin B 12 -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79970877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Disruption+of+folate+and+vitamin+B12+metabolism+in+aged+rats+following+exposure+to+nitrous+oxide.&rft.au=Koblin%2C+D+D%3BTomerson%2C+B+W%3BWaldman%2C+F+M&rft.aulast=Koblin&rft.aufirst=D&rft.date=1990-09-01&rft.volume=73&rft.issue=3&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Itraconazole treatment of coccidioidomycosis. NAIAD Mycoses Study Group. AN - 79970587; 2168126 AB - The purpose of this study was to assess the tolerance and efficacy of itraconazole in the treatment of coccidioidomycosis. Fifty-one patients with nonmeningeal coccidioidomycosis were considered for treatment with intraconazole. Forty-nine patients who met study criteria were treated with itraconazole given orally in doses of 100 to 400 mg/day for periods up to 39 months. Of these patients, 12 had osteoarticular disease, 23 had chronic pulmonary disease, and 14 had skin or soft tissue disease. Clinical response was evaluated using a scoring system accounting for lesion number and size, symptoms, culture, and serologic titer. Remission was defined as reduction of the pretreatment score by 50% or more. Patients with osteoarticular, chronic pulmonary, and soft tissue disease improved at similar rates. Because two patients had no scoring assessment for efficacy, they were considered inassessable for efficacy. Forty-seven patients are evaluable. Of these patients, 44 have completed therapy, and three are still receiving itraconazole. Of the 44 patients no longer receiving therapy, 25 (57%) achieved remission. Of the 25 patients achieving remission, four later experienced a relapse. Therapy failed in 19 patients (43%). Of these cases, 16 (36%) were clinical failures and three (7%) developed drug intolerance that precluded continuation of treatment. Evaluation of culture conversions was of limited value in the osteoarticular patients, fewer than half of whom had follow-up biopsies. However, culture conversions were a useful index of response in patients with chronic pulmonary disease. During the course of treatment, serologic titers declined in the two groups with extrapulmonary disease, but not in patients with pulmonary coccidioidomycosis. Possible toxicities were generally mild. Itraconazole appears efficacious and very well tolerated in patients with coccidioidomycosis. JF - The American journal of medicine AU - Graybill, J R AU - Stevens, D A AU - Galgiani, J N AU - Dismukes, W E AU - Cloud, G A AD - Medical Service, Audie Murphy Veterans Administration Hospital, San Antonio, Texas 78284. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 282 EP - 290 VL - 89 IS - 3 SN - 0002-9343, 0002-9343 KW - Antifungal Agents KW - 0 KW - Itraconazole KW - 304NUG5GF4 KW - Ketoconazole KW - R9400W927I KW - Abridged Index Medicus KW - Index Medicus KW - Bone Diseases -- drug therapy KW - Lung Diseases, Fungal -- drug therapy KW - Dermatomycoses -- drug therapy KW - Humans KW - Drug Resistance, Microbial KW - Aged KW - Recurrence KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Joint Diseases -- drug therapy KW - Remission Induction KW - Antifungal Agents -- toxicity KW - Ketoconazole -- toxicity KW - Ketoconazole -- therapeutic use KW - Ketoconazole -- analogs & derivatives KW - Ketoconazole -- administration & dosage KW - Antifungal Agents -- administration & dosage KW - Coccidioidomycosis -- drug therapy KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79970587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Itraconazole+treatment+of+coccidioidomycosis.+NAIAD+Mycoses+Study+Group.&rft.au=Graybill%2C+J+R%3BStevens%2C+D+A%3BGalgiani%2C+J+N%3BDismukes%2C+W+E%3BCloud%2C+G+A&rft.aulast=Graybill&rft.aufirst=J&rft.date=1990-09-01&rft.volume=89&rft.issue=3&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Marked spontaneous improvement in ejection fraction in patients with congestive heart failure. AN - 79966827; 2203261 AB - The overall prognosis for patients with congestive heart failure is poor. Defining specific populations that might demonstrate improved survival has been difficult. We therefore examined our patient database for patients with congestive heart failure who demonstrated sustained improvement in left ventricular function and associated resolution of signs and symptoms of congestive heart failure. We identified 11 patients with severe congestive heart failure (average ejection fraction 21.9 +/- 4.23% (+/- SD) who developed spontaneous, marked improvement over a period of follow-up lasting 4.25 +/- 1.49 years. All 11 patients were initially symptomatic with exertional dyspnea and fatigue for a minimum duration of 3 months. They form a subset of a larger group of 97 patients with chronic congestive heart failure that we have followed with sequential ejection fraction measurements. All 11 patients were treated with digitalis diuretics, and either converting-enzyme inhibitors or a combination of isosorbide dinitrate and hydralazine. Ten of the 11 patients had a history consistent with chronic alcoholism, and each reportedly abstained from alcohol during follow-up. During the follow-up period, the average ejection fraction improved in 11 patients from 21.9 +/- 4.23% to 56.64 +/- 10.22%. Late follow-up indicates an average ejection fraction of 52.6 +/- 8.55% for the group. Congestive heart failure resolved in each case. We conclude that selected patients with severe congestive heart failure can markedly improve their left ventricular function in association with complete resolution of heart failure. This appears to be particularly evident in those patients with chronic alcoholism who subsequently abstain. JF - The American journal of medicine AU - Francis, G S AU - Johnson, T H AU - Ziesche, S AU - Berg, M AU - Boosalis, P AU - Cohn, J N AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 303 EP - 307 VL - 89 IS - 3 SN - 0002-9343, 0002-9343 KW - Diuretics KW - 0 KW - Enalapril KW - 69PN84IO1A KW - Digoxin KW - 73K4184T59 KW - Captopril KW - 9G64RSX1XD KW - Abridged Index Medicus KW - Index Medicus KW - Captopril -- therapeutic use KW - Diuretics -- therapeutic use KW - Digoxin -- therapeutic use KW - Enalapril -- therapeutic use KW - Humans KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Alcoholism -- prevention & control KW - Male KW - Remission Induction KW - Stroke Volume -- physiology KW - Heart Failure -- drug therapy KW - Heart Failure -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79966827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Marked+spontaneous+improvement+in+ejection+fraction+in+patients+with+congestive+heart+failure.&rft.au=Francis%2C+G+S%3BJohnson%2C+T+H%3BZiesche%2C+S%3BBerg%2C+M%3BBoosalis%2C+P%3BCohn%2C+J+N&rft.aulast=Francis&rft.aufirst=G&rft.date=1990-09-01&rft.volume=89&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal functional response to dopamine during and after arteriography in patients with chronic renal insufficiency. AN - 79959116; 2202010 AB - The potential renal vasodilatory effect of dopamine in improving renal function after arteriography was studied. Sixty patients with preexisting renal insufficiency were prospectively randomized into two groups. Patients in the treated group (n = 30) received an infusion of dopamine for 12 hours starting at the beginning of arteriography. Patients who received placebo infusion with arteriography (n = 30) served as controls. The study was conducted in two different time intervals. In the first interval, serum creatinine levels and 12-hour creatinine clearance values were obtained before and immediately after arteriography in 12 patients in the dopamine group and 13 patients in the control group. In the second interval, the same variables were measured before arteriography and for 3 consecutive days after arteriography in 18 patients in the dopamine group and 17 patients in the control group. Serum creatinine levels became significantly elevated in the control group on the 1st day and remained so on the 3rd day after arteriography, whereas the dopamine group did not show significant elevation of these levels. Creatinine clearance decreased in the control group on the 1st day, but this deterioration was not sustained on the 3rd day. In the dopamine group, there was no deterioration in creatinine clearance on either day, and mean effective renal plasma flow during and after arteriography was greater. JF - Radiology AU - Hans, B AU - Hans, S S AU - Mittal, V K AU - Khan, T A AU - Patel, N AU - Dahn, M S AD - Department of Radiology, Veterans Administration Medical Center, Allen Park, Mich. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 651 EP - 654 VL - 176 IS - 3 SN - 0033-8419, 0033-8419 KW - Diatrizoate KW - 117-96-4 KW - Creatinine KW - AYI8EX34EU KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Kidney Function Tests KW - Randomized Controlled Trials as Topic KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Creatinine -- blood KW - Angiography KW - Dopamine -- therapeutic use KW - Diatrizoate -- adverse effects KW - Kidney Failure, Chronic -- drug therapy KW - Kidney -- drug effects KW - Diatrizoate -- therapeutic use KW - Kidney Failure, Chronic -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79959116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Renal+functional+response+to+dopamine+during+and+after+arteriography+in+patients+with+chronic+renal+insufficiency.&rft.au=Hans%2C+B%3BHans%2C+S+S%3BMittal%2C+V+K%3BKhan%2C+T+A%3BPatel%2C+N%3BDahn%2C+M+S&rft.aulast=Hans&rft.aufirst=B&rft.date=1990-09-01&rft.volume=176&rft.issue=3&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-25 N1 - Date created - 1990-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Visual disturbances, serum glycine levels and transurethral resection of the prostate. AN - 79951900; 2388330 AB - Transient visual disturbances have been noted in patients undergoing transurethral resection of the prostate. It has been suggested recently that these visual aberrations were secondary to high serum concentrations of glycine from the intravasation of irrigant solutions used during the procedure. We prospectively studied visual acuity, serum electrolytes, glucose, ammonia and glycine concentrations in 18 patients undergoing transurethral resection of the prostate. Of our patient population 22% experienced significant decreases in visual acuity. We found that all patients had significantly elevated serum glycine concentrations but that there was no correlation of visual symptomatology with serum electrolyte or glucose concentrations. Our data further suggest that impeded metabolism of glycine may be more important than the absolute serum concentration in symptomatic patients. JF - The Journal of urology AU - Mizutani, A R AU - Parker, J AU - Katz, J AU - Schmidt, J AD - Department of Anesthesiology, San Diego Veterans Administration Medical Center, California. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 697 EP - 699 VL - 144 IS - 3 SN - 0022-5347, 0022-5347 KW - Blood Glucose KW - 0 KW - Ammonia KW - 7664-41-7 KW - Glycine KW - TE7660XO1C KW - Abridged Index Medicus KW - Index Medicus KW - Therapeutic Irrigation KW - Ammonia -- blood KW - Humans KW - Blood Glucose -- analysis KW - Visual Acuity KW - Male KW - Vision Disorders -- chemically induced KW - Prostatectomy KW - Glycine -- adverse effects KW - Postoperative Complications -- etiology KW - Glycine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79951900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Visual+disturbances%2C+serum+glycine+levels+and+transurethral+resection+of+the+prostate.&rft.au=Mizutani%2C+A+R%3BParker%2C+J%3BKatz%2C+J%3BSchmidt%2C+J&rft.aulast=Mizutani&rft.aufirst=A&rft.date=1990-09-01&rft.volume=144&rft.issue=3&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-21 N1 - Date created - 1990-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intrinsic nerves affect gallbladder contraction in the guinea pig. AN - 79919449; 2379785 AB - Muscarinic antagonists block gallbladder contraction induced by cholecystokinin in vivo but have little effect on gallbladder muscle strips. This study examined the effect of neural blockade on cholecystokinin-octapeptide-induced contraction of the intact guinea pig gallbladder in vitro using cholecystokinin-octapeptide applied to the gallbladder serosa, the lumen, or both compartments simultaneously. Simultaneous cholecystokinin stimulation of both the lumen and serosa was the most potent stimulus to contraction, and the responses were significantly inhibited by atropine and tetrodotoxin. Cholecystokinin in the gallbladder lumen alone evoked contraction by a dose-dependent mechanism that was entirely blocked by atropine or tetrodotoxin. Serosal application of cholecystokinin was the least potent, resulting in contractile responses and low sensitivity to neural blockers comparable to effects reported in muscle strips. The results suggest that cholecystokinin can cause gallbladder contraction by stimulating muscle receptors, neural receptors, or both, and combined neural and muscular stimulation is the most potent contractile stimulus. JF - Gastroenterology AU - Brotschi, E A AU - Pattavino, J AU - Williams, L F AD - Department of Surgery, Boston Veterans Administration Medical Center, Massachusetts. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 826 EP - 830 VL - 99 IS - 3 SN - 0016-5085, 0016-5085 KW - Tetrodotoxin KW - 4368-28-9 KW - Atropine KW - 7C0697DR9I KW - Sincalide KW - M03GIQ7Z6P KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Muscle Contraction -- drug effects KW - In Vitro Techniques KW - Sincalide -- antagonists & inhibitors KW - Tetrodotoxin -- pharmacology KW - Atropine -- pharmacology KW - Sincalide -- pharmacology KW - Female KW - Gallbladder -- drug effects KW - Gallbladder -- innervation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79919449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Intrinsic+nerves+affect+gallbladder+contraction+in+the+guinea+pig.&rft.au=Brotschi%2C+E+A%3BPattavino%2C+J%3BWilliams%2C+L+F&rft.aulast=Brotschi&rft.aufirst=E&rft.date=1990-09-01&rft.volume=99&rft.issue=3&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-13 N1 - Date created - 1990-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Somatostatin monoclonal antibody immunoneutralization increases gastrin and gastric acid secretion in urethane-anesthetized rats. AN - 79915493; 1974217 AB - The role of endogenous somatostatin in mediating urethane anesthesia-induced inhibition of gastric acid secretion was investigated using measurement of somatostatin messenger RNA concentrations in the antrum and the influence of somatostatin monoclonal antibody CURE.S6 on acid secretion in rats anesthetized with urethane and acutely implanted with gastric fistulas. Fifteen minutes after injection of urethane, somatostatin messenger RNA concentrations were increased by 128% compared with those in nontreated rats. The significant elevation of somatostatin messenger RNA was maintained for 2 hours after injection. Somatostatin monoclonal antibody injected intravenously (2 mg) completely reversed the inhibitory effect of somatostatin (20 micrograms/kg.h) on pentagastrin (24 micrograms/kg.h)-stimulated gastric acid secretion. The somatostatin monoclonal antibody dose dependently increased basal gastric acid secretion in urethane-anesthetized rats. Peak acid response to the somatostatin monoclonal antibody (2 mg) was observed 20 minutes after antibody injection (preinjection, 1.4 +/- 1.2 mumol/10 min; postinjection, 10.6 +/- 0.6 mumol/10 min); meanwhile, levels of plasma gastrin increased from 27 +/- 6 pg/mL to 75 +/- 8 pg/mL and were maintained elevated for the 2-hour experimental period. When gastrin monoclonal antibody 28.2 was injected together with somatostatin monoclonal antibody, the stimulatory effect of the somatostatin antibody was inhibited by 82%. A control monoclonal antibody 109-21 directed against the biologically inactive glycine-extended fragment 66-72 of progastrin did not alter basal gastric acid secretion or the inhibitory effect of somatostatin. These results indicate that one mechanism by which urethane induced low basal gastric acid secretion involved increased synthesis and release of endogenous somatostatin and associated inhibition of gastrin secretion. JF - Gastroenterology AU - Yang, H AU - Wong, H AU - Wu, V AU - Walsh, J H AU - Taché, Y AD - Center for Ulcer Research and Education, Veterans Administration Medical Center, Los Angeles. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 659 EP - 665 VL - 99 IS - 3 SN - 0016-5085, 0016-5085 KW - Anesthetics KW - 0 KW - Antibodies, Monoclonal KW - Gastrins KW - RNA, Messenger KW - Urethane KW - 3IN71E75Z5 KW - Somatostatin KW - 51110-01-1 KW - Pentagastrin KW - EF0NX91490 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - RNA, Messenger -- metabolism KW - Pyloric Antrum -- physiology KW - Pentagastrin -- pharmacology KW - RNA, Messenger -- drug effects KW - Monitoring, Physiologic KW - Antibodies, Monoclonal -- pharmacology KW - Male KW - Somatostatin -- physiology KW - Anesthetics -- pharmacology KW - Somatostatin -- immunology KW - Gastrins -- secretion KW - Urethane -- pharmacology KW - Gastric Acid -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79915493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Somatostatin+monoclonal+antibody+immunoneutralization+increases+gastrin+and+gastric+acid+secretion+in+urethane-anesthetized+rats.&rft.au=Yang%2C+H%3BWong%2C+H%3BWu%2C+V%3BWalsh%2C+J+H%3BTach%C3%A9%2C+Y&rft.aulast=Yang&rft.aufirst=H&rft.date=1990-09-01&rft.volume=99&rft.issue=3&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-13 N1 - Date created - 1990-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Failure of a Diagnostic Monoclonal Immunofluorescent Reagent to Detect Legionella pneumophila in Environmental Samples AN - 19105703; 9101764 AB - Three commercial diagnostic fluorescein-labeled antibodies, one monoclonal and two polyclonal, were compared to evaluate their abilities to detect Legionella pneumophila in environmental samples collected from 4 hospitals, one nursing home, and one industrial plant. The samples were taken from 9 hot and cold storage tank waters, three swabs from two showers and 1 faucet. The monoclonal conjugate failed to detect L. pneumophila in the 12 environmental samples studied by direct immunofluorescence. In contrast, the two polyclonal conjugates detected L. pneumophila in all 12 samples by both direct and indirect immunofluorescence. However, isolates recovered by culture from the 12 samples demonstrated equal immunofluorescence with all three conjugates. The reason for the failure of the monoclonal antibody to detect L. pneumophila in the environmental samples remains unknown. Laboratories considering the use of the monoclonal conjugate to screen environmental samples for L. pneumophila should be aware of this finding. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF, Vol. 56, No. 9, p 2912-2914, September 1990. 1 tab, 10 ref. AU - Yu, V L AU - Stout, JE AU - Vickers, R M AD - Veterans Administration Medical Center Y1 - 1990/09// PY - 1990 DA - Sep 1990 KW - Water Resources Abstracts KW - Fluorescence Hospitals Immunoassay Legionella Pathogenic KW - bacteria Pollutant identification Human pathogens Potable water KW - Water distribution KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19105703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Failure+of+a+Diagnostic+Monoclonal+Immunofluorescent+Reagent+to+Detect+Legionella+pneumophila+in+Environmental+Samples&rft.au=Yu%2C+V+L%3BStout%2C+JE%3BVickers%2C+R+M&rft.aulast=Yu&rft.aufirst=V&rft.date=1990-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Decreased induction of an hepatic mRNA by phorbol esters after insulin desensitization. AN - 80245255; 2282974 AB - Insulin and phorbol esters rapidly induce the transcription and cytoplasmic accumulation of a specific mRNA (p33) in rat hepatoma cells. We have studied the effects of insulin desensitization on the regulation of p33 gene expression by insulin and phorbol esters. Insulin desensitization is associated with down-regulation of the insulin receptor and post-receptor defects. When cells were treated with insulin (5 x 10(-7) M) for 24 h, a greater than 50% reduction in insulin binding was observed and insulin's stimulation of p33 transcription and cytoplasmic mRNA levels was prevented. The induction of p33 gene transcription and mRNA levels by phorbol esters was also decreased. Beta-tubulin gene expression was unaffected by insulin or phorbol esters and the stimulatory effect of dexamethasone on p33 gene expression was not impaired. Since insulin desensitization impaired phorbol esters' induction of p33 gene expression, one intracellular defect in insulin-desensitized cells may include an alteration in protein kinase C-dependent events. JF - Molecular and cellular endocrinology AU - Weinstock, R S AU - Messina, J L AD - Department of Medicine, Veterans Administration Medical Center, Syracuse, NY 13210. Y1 - 1990/08/20/ PY - 1990 DA - 1990 Aug 20 SP - 121 EP - 129 VL - 72 IS - 2 SN - 0303-7207, 0303-7207 KW - Insulin KW - 0 KW - RNA, Messenger KW - Tubulin KW - Dexamethasone KW - 7S5I7G3JQL KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Drug Tolerance KW - Animals KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured KW - Cytoplasm -- metabolism KW - Dexamethasone -- pharmacology KW - Tubulin -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Liver Neoplasms, Experimental -- metabolism KW - Insulin -- pharmacology KW - Gene Expression Regulation -- drug effects KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80245255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Decreased+induction+of+an+hepatic+mRNA+by+phorbol+esters+after+insulin+desensitization.&rft.au=Weinstock%2C+R+S%3BMessina%2C+J+L&rft.aulast=Weinstock&rft.aufirst=R&rft.date=1990-08-20&rft.volume=72&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-18 N1 - Date created - 1991-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. AN - 79895955; 2374275 AB - Recently, nicotinic acid has been recommended as a first-line hypolipidemic drug. To determine the effectiveness of nicotinic acid in dyslipidemic patients with non-insulin-dependent diabetes mellitus, 13 patients were treated in a randomized crossover trial. Patients received either nicotinic acid (1.5 g three times daily) or no therapy (control period) for 8 weeks each. Compared with the control period, nicotinic acid therapy reduced the plasma total cholesterol level by 24%, plasma triglyceride level by 45%, very-low-density lipoprotein cholesterol level by 58%, and low-density lipoprotein cholesterol level by 15%, and it increased the high-density lipoprotein cholesterol level by 34%. However, nicotinic acid therapy resulted in the deterioration of glycemic control, as evidenced by a 16% increase in mean plasma glucose concentrations, a 21% increase in glycosylated hemoglobin levels, and the induction of marked glycosuria in some patients. Furthermore, a consistent increase in plasma uric acid levels was observed. Therefore, despite improvement in lipid and lipoprotein concentrations, because of worsening hyperglycemia and the development of hyperuricemia, nicotinic acid must be used with caution in patients with non-insulin-dependent diabetes mellitus with dyslipidemia. We suggest that the drug not be used as a first-line hypolipidemic drug in patients with non-insulin-dependent diabetes mellitus. JF - JAMA AU - Garg, A AU - Grundy, S M AD - Veterans Administration Medical Center, Dallas, TX. Y1 - 1990/08/08/ PY - 1990 DA - 1990 Aug 08 SP - 723 EP - 726 VL - 264 IS - 6 SN - 0098-7484, 0098-7484 KW - Blood Glucose KW - 0 KW - Cholesterol, HDL KW - Cholesterol, LDL KW - Lipids KW - Lipoproteins KW - Triglycerides KW - lipoprotein cholesterol KW - Niacin KW - 2679MF687A KW - Cholesterol KW - 97C5T2UQ7J KW - Abridged Index Medicus KW - Index Medicus KW - Triglycerides -- blood KW - Cholesterol, LDL -- blood KW - Cholesterol -- blood KW - Analysis of Variance KW - Cholesterol, HDL -- blood KW - Humans KW - Aged KW - Middle Aged KW - Blood Glucose -- analysis KW - Lipoproteins -- blood KW - Male KW - Clinical Protocols KW - Lipids -- blood KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Niacin -- adverse effects KW - Diabetes Mellitus, Type 2 -- blood KW - Niacin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79895955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Nicotinic+acid+as+therapy+for+dyslipidemia+in+non-insulin-dependent+diabetes+mellitus.&rft.au=Garg%2C+A%3BGrundy%2C+S+M&rft.aulast=Garg&rft.aufirst=A&rft.date=1990-08-08&rft.volume=264&rft.issue=6&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-24 N1 - Date created - 1990-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1990 Dec 19;264(23):2994-6 [2288621] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk factors for pneumonia after percutaneous endoscopic gastrostomy. AN - 85200509; pmid-2398246 AB - Percutaneous endoscopic gastrostomy (PEG) is currently a popular method of administering enteral feeding. Most of these patients are elderly, debilitated, and chronically ill. They are on a number of medications and have multiple diseases. With impaired consciousness and swallowing disability, these patients are prone to develop pneumonia. In order to identify possible risk factors, we followed 24 men who underwent PEG for the occurrence of pneumonia or until they died. We then analyzed the medical records of these patients for potential risk factors for pneumonia. The presence of esophagitis during PEG placement endoscopy and history of pneumonia prior to PEG were significant risk factors. Advanced age and cerebrovascular accident (CVA) tended to indicate a higher risk of pneumonia. Taking these risk factors into consideration may be beneficial in the management of such patients. JF - Journal of Clinical Gastroenterology AU - Patel, P H AU - Thomas, E AD - Department of Medicine, Veterans Administration Medical Center, Johnson City, TN 37684. PY - 1990 SP - 389 EP - 392 VL - 12 IS - 4 SN - 0192-0790, 0192-0790 KW - Esophagitis KW - Gastrostomy KW - Age Factors KW - Aged, 80 and over KW - Human KW - Risk Factors KW - Aged KW - Middle Age KW - Cerebrovascular Disorders KW - Male KW - Pneumonia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85200509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Risk+factors+for+pneumonia+after+percutaneous+endoscopic+gastrostomy.&rft.au=Patel%2C+P+H%3BThomas%2C+E&rft.aulast=Patel&rft.aufirst=P&rft.date=1990-08-01&rft.volume=12&rft.issue=4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - "Isolated" elevation of alkaline phosphatase: significance in hospitalized patients. AN - 85197866; pmid-2398249 AB - The significance of alkaline phosphatase (AP) elevation with otherwise normal transaminase and bilirubin values remains unclear. We evaluated the clinical outcome of hospitalized patients with an "isolated" AP elevation. Eighty-seven inpatients with isolated AP elevation were identified during February 1984 and followed for 1 year. Forty-five of 87 patients had normalization of AP during the follow-up period, usually within 1-3 months. The most common diagnoses in this group were congestive heart failure in nine, benign bone disease in six, and treatable malignancy in three patients. Twelve patients had no apparent explanation for the transient rise of AP. Persistent AP elevations were noted in 42 patients--14 of whom had terminal malignancies. Clinically obvious life-threatening diagnoses were made in 24 of the patients with persistent AP elevation. The etiology of AP elevation remained enigmatic in seven patients: two died, four are stable during 1 1/2-3 years of follow-up, and one patient was found to have metastatic carcinoma 17 months later. If the initial AP was greater than 1 1/2 times normal, there was a higher likelihood of persistent elevation (68% vs. 41%, p less than 0.05). Isolated elevations of AP in inpatients may be associated with a variety of medical illnesses and often normalize within months. If the AP elevation is persistent, there is usually a clinically obvious diagnosis. A reasonable approach to such patients is a careful history, physical exam, and routine lab studies to detect obvious diagnoses, followed by repeat enzyme determination at 1-3 months. JF - Journal of Clinical Gastroenterology AU - Lieberman, D AU - Phillips, D AD - Department of Medicine, Portland Veterans Administration Medical Center, OR 97207. PY - 1990 SP - 415 EP - 419 VL - 12 IS - 4 SN - 0192-0790, 0192-0790 KW - Liver Diseases KW - Neoplasms KW - Hospitalization KW - Biliary Tract Diseases KW - Human KW - Retrospective Studies KW - Alkaline Phosphatase KW - Bilirubin KW - Bone Diseases KW - Heart Failure, Congestive KW - Transaminases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85197866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=%22Isolated%22+elevation+of+alkaline+phosphatase%3A+significance+in+hospitalized+patients.&rft.au=Lieberman%2C+D%3BPhillips%2C+D&rft.aulast=Lieberman&rft.aufirst=D&rft.date=1990-08-01&rft.volume=12&rft.issue=4&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Human disease consequences of fiber exposures: a review of human lung pathology and fiber burden data. AN - 80210572; 2272326 AB - Inhalation of asbestos fibers results in a variety of neoplastic and nonneoplastic diseases of the respiratory tract. Some of these diseases, such as asbestosis, generally occur after prolonged and intensive exposure to asbestos, whereas others, such as pleural mesothelioma, may occur following brief exposures. Inhalation of nonasbestiform mineral fibers can occur as well, and these fibers can be recovered from human lung tissue. Thus, there has been considerable interest in the relationship between mineral fiber content of the lung and various pathologic changes. Techniques for fiber analysis of human tissues have not been standardized, and consequently results may differ appreciably from one laboratory to another. In all reported series, extremely high fiber burdens are found in the lungs of individuals with asbestosis. Although there is a correlation between the tissue concentration of asbestos fibers and the severity of pulmonary fibrosis, further studies of the mineralogic correlates of fiber-induced pulmonary fibrosis are needed. Mesothelioma may occur with fiber burdens considerably less than those necessary to produce asbestosis. More information is needed regarding the migration of fibers to the pleura and the numbers, types, and dimensions of fibers that accumulate at that site. Patients with asbestosis have a markedly increased risk for lung cancer, but the risk of lung cancer attributable to asbestos in exposed workers without asbestosis who also smoke is controversial. Combined epidemiologic-mineralogic studies of a well-defined cohort are needed to resolve this issue. In addition, more information is needed regarding the potential role of nonasbestos mineral fibers in the pathogenesis of lung cancer. JF - Environmental health perspectives AU - Roggli, V L AD - Durham Veterans Administration, NC. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 295 EP - 303 VL - 88 SN - 0091-6765, 0091-6765 KW - Minerals KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Pleural Diseases -- pathology KW - Lung Neoplasms -- etiology KW - Pleural Diseases -- etiology KW - Humans KW - Asbestosis -- pathology KW - Mesothelioma -- etiology KW - Mesothelioma -- pathology KW - Asbestos -- adverse effects KW - Asbestosis -- etiology KW - Lung Neoplasms -- pathology KW - Lung Diseases -- etiology KW - Lung Diseases -- pathology KW - Minerals -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80210572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Human+disease+consequences+of+fiber+exposures%3A+a+review+of+human+lung+pathology+and+fiber+burden+data.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1990-08-01&rft.volume=88&rft.issue=&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-28 N1 - Date created - 1991-02-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Environ Health. 1974 Aug;29(2):115-7 [4835180] Br J Ind Med. 1986 Mar;43(3):145-9 [3511951] Am Rev Respir Dis. 1976 Jul;114(1):187-227 [779552] Thorax. 1977 Aug;32(4):377-86 [929482] Ann N Y Acad Sci. 1979;330:473-90 [294198] N Engl J Med. 1980 Jul 24;303(4):200-2 [6155613] Cancer. 1980 Oct 1;46(7):1650-6 [7417959] Am Rev Respir Dis. 1980 Nov;122(5):669-78 [7447151] J Natl Cancer Inst. 1981 Nov;67(5):965-75 [6946253] Scand J Work Environ Health. 1981 Jun;7(2):109-13 [7313614] Hum Pathol. 1982 Apr;13(4):381-92 [6281166] N Engl J Med. 1982 Jun 17;306(24):1446-55 [7043267] Am J Pathol. 1982 Oct;109(1):37-46 [7124907] Am J Pathol. 1982 Oct;109(1):88-96 [7124910] Arch Pathol Lab Med. 1982 Oct 8;106(11):544-96 [6897166] Ann Occup Hyg. 1982;25(3):317-31 [7181257] Br J Ind Med. 1983 Feb;40(1):45-50 [6824599] Environ Res. 1983 Jun;31(1):189-200 [6851981] Chest. 1983 Sep;84(3):275-80 [6884101] Chest. 1983 Nov;84(5):601-8 [6628014] Environ Res. 1984 Feb;33(1):62-75 [6692815] Arch Pathol Lab Med. 1984 Feb;108(2):93 [6546497] Pathol Annu. 1983;18 Pt 2:109-45 [6674859] Am J Pathol. 1984 Jun;115(3):437-42 [6329002] Cancer. 1984 Sep 1;54(5):951-60 [6331632] Am Rev Respir Dis. 1984 Dec;130(6):1042-5 [6095707] JAMA. 1985 May 24-31;253(20):2984-5 [2987551] Scand J Work Environ Health. 1985 Apr;11(2):107-10 [4001898] Crit Rev Clin Lab Sci. 1985;22(1):1-42 [3891228] Am Rev Respir Dis. 1985 Jul;132(1):143-7 [4014859] Ann Thorac Surg. 1985 Jul;40(1):82-96 [4015250] Thorax. 1986 Mar;41(3):161-6 [3715773] Br J Ind Med. 1986 Jun;43(6):391-5 [3718883] Ann Occup Hyg. 1986;30(4):411-25 [3813348] Occup Med. 1987 Apr-Jun;2(2):259-72 [3303380] Environ Res. 1987 Oct;44(1):29-44 [3653068] Thorax. 1987 Aug;42(8):583-8 [3660310] Arch Environ Health. 1987 Jul-Aug;42(4):185-91 [2821933] Pathol Annu. 1987;22 Pt 2:91-131 [2825103] Chest. 1988 Mar;93(3):621-8 [2830081] Environ Res. 1988 Jun;46(1):86-106 [3286241] Br J Ind Med. 1988 Aug;45(8):544-7 [3415920] Am Rev Respir Dis. 1989 Apr;139(4):891-6 [2539033] Ann N Y Acad Sci. 1965 Dec 31;132(1):507-18 [5219571] J Occup Med. 1973 Mar;15(3):287-95 [4571332] J Clin Pathol. 1973 Mar;26(3):224-34 [4573359] Inhaled Part. 1970;2:661-70 [5527734] Cancer. 1985 Sep 1;56(5):1089-93 [4016698] Environ Res. 1985 Aug;37(2):364-72 [4017991] Monogr Pathol. 1985;(26):211-21 [2932634] Chest. 1986 Jan;89(1):20-6 [3940784] Environ Res. 1986 Feb;39(1):232-6 [2417833] Br J Ind Med. 1986 Jan;43(1):18-28 [3947558] Cancer. 1975 Apr;35(4):1236-42 [1116110] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Posthypoxic glucose supplement reduces hypoxic-ischemic brain damage in the neonatal rat. AN - 80071961; 2221842 AB - We evaluated the effect of posthypoxic glucose supplement in a neonatal hypoxic-ischemic animal model. Seven-day-old rats underwent bilateral ligation of the carotid arteries, followed by exposure to an 8% oxygen atmosphere for 1 hour. The extent of hypoxic-ischemic brain damage was assessed histologically 72 hours later. Glucose load immediately after the end of the hypoxic exposure reduced the volume of neocortical infarction to 37% of the unsupplemented value, and attenuated ischemic damage in the striatum and the dentate gyrus. At the end of the hypoxic exposure, the brain level of glucose was 0.3 mmol/kg and the level of lactate 9 mmol/kg. Glucose supplement produced a rapid rise in brain glucose level to 3 to 5 mmol/kg over the next 2 hours. Lactate in both brain and plasma gradually fell toward the baseline level during the first hour of recovery. Posthypoxic glucose supplement slightly retarded lactate restitution. At any period of this neonatal model, brain lactate levels did not exceed the toxic level, which is postulated to be responsible for cerebral infarction in adult ischemic models. These results illustrate the important role of glucose in the development of neonatal hypoxic-ischemic encephalopathy and the fact that full cortical infarction can develop even if brain lactate levels are low. JF - Annals of neurology AU - Hattori, H AU - Wasterlain, C G AD - Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 122 EP - 128 VL - 28 IS - 2 SN - 0364-5134, 0364-5134 KW - Lactates KW - 0 KW - Lactic Acid KW - 33X04XA5AT KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Lactates -- metabolism KW - Age Factors KW - Cerebral Cortex -- pathology KW - Brain Chemistry KW - Corpus Striatum -- pathology KW - Cerebral Infarction -- etiology KW - Hypoxia -- complications KW - Hypoxia -- pathology KW - Brain Ischemia -- drug therapy KW - Brain Ischemia -- pathology KW - Hypoxia -- drug therapy KW - Brain -- pathology KW - Glucose -- therapeutic use KW - Animals, Newborn -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80071961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Posthypoxic+glucose+supplement+reduces+hypoxic-ischemic+brain+damage+in+the+neonatal+rat.&rft.au=Hattori%2C+H%3BWasterlain%2C+C+G&rft.aulast=Hattori&rft.aufirst=H&rft.date=1990-08-01&rft.volume=28&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=03645134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-16 N1 - Date created - 1990-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The mechanism of action of tumour necrosis factor-alpha and interleukin 1 on FRTL-5 rat thyroid cells. AN - 80065318; 2171291 AB - Previous work showed that treatment of rats with tumour necrosis factor-alpha produced a model of nonthyroid illness in which there was reduction of circulating thyroid hormones and TSH, reduced thyroid response to TSH, and reduced thyroid iodide uptake. In vitro studies showed that tumour necrosis factor-alpha binds to a specific receptor on FRTL-5 rat thyroid cells, that TSH increases the number of tumour necrosis factor-alpha receptors, and that tumour necrosis factor-alpha inhibits iodide uptake by these cells. In the present study, we obtained additional data on the effects of tumour necrosis factor-alpha on FRTL-5 cells and studied the mechanism of action of tumour necrosis factor-alpha in these cells. Tumour necrosis factor-alpha inhibited both basal and TSH-stimulated [125I]iodide uptake: tumour necrosis factor-alpha slowed the recovery of [125I]iodide trapping after the cells were exposed to TSH and augmented the loss of the [125I]iodide trapping function after the cells were deprived of TSH: tumour necrosis factor-alpha inhibited [125I]iodide trapping in a noncompetitive manner; tumour necrosis factor-alpha did not affect cell growth of FRTL-5 cells. Interleukin-1 (IL-1) also inhibited basal and TSH-stimulated [125I]iodide uptake, but it stimulated cell growth. Tumour necrosis factor-alpha and IL-1 did not affect the generation of cAMP in the presence or absence of TSH; these cytokines blocked the cAMP-induced stimulation of [125I]iodide uptake. Tumour necrosis factor-alpha did not affect [3H]arachidonic acid uptake or release by FRTL-5 cells. The inhibitors of the phospholipase A2-arachidonic acid pathway did not affect the action of tumour necrosis factor-alpha.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Acta endocrinologica AU - Pang, X P AU - Hershman, J M AU - Smith, V AU - Pekary, A E AU - Sugawara, M AD - Endocrine Research Laboratory, Wadsworth Veterans Administration Medical Center, Los Angeles, CA. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 203 EP - 210 VL - 123 IS - 2 SN - 0001-5598, 0001-5598 KW - Interleukin-1 KW - 0 KW - Iodides KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Cyclic AMP KW - E0399OZS9N KW - Catalase KW - EC 1.11.1.6 KW - Index Medicus KW - Rats KW - Cyclic AMP -- biosynthesis KW - Animals KW - Thyrotropin -- pharmacology KW - Recombinant Proteins -- pharmacology KW - Cells, Cultured KW - Iodides -- pharmacokinetics KW - Cyclic AMP -- pharmacology KW - DNA -- analysis KW - Drug Synergism KW - Catalase -- pharmacology KW - Biological Transport -- drug effects KW - Thyroid Gland -- chemistry KW - Interleukin-1 -- pharmacology KW - Thyroid Gland -- physiology KW - Thyroid Gland -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80065318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+endocrinologica&rft.atitle=The+mechanism+of+action+of+tumour+necrosis+factor-alpha+and+interleukin+1+on+FRTL-5+rat+thyroid+cells.&rft.au=Pang%2C+X+P%3BHershman%2C+J+M%3BSmith%2C+V%3BPekary%2C+A+E%3BSugawara%2C+M&rft.aulast=Pang&rft.aufirst=X&rft.date=1990-08-01&rft.volume=123&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Acta+endocrinologica&rft.issn=00015598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-09 N1 - Date created - 1990-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro comparison of mezlocillin and piperacillin plus tobramycin or gentamicin versus 100 gram-negative nosocomial bloodstream isolates. AN - 80007670; 2403216 AB - We compared the in vitro activity of mezlocillin and piperacillin, alone and in combination with tobramycin or gentamicin, against clinical isolates of gram-negative bacilli from hospitalized patients with 100 distinct episodes of nosocomial bacteremia. The minimum inhibitory concentrations (MICs) necessary to inhibit 50% and 90% of isolates showed that piperacillin was most active against Pseudomonas aeruginosa. The MIC needed to inhibit 90% of isolates also showed that mezlocillin was more active against Enterobacter cloacae. Activities of the two acylaminopenicillins were comparable against the rest of the isolates. Combining the acylaminopenicillins with either gentamicin or tobramycin decreased the MICs fourfold or more for both combinations. Synergy occurred more frequently with mezlocillin-gentamicin (12%), followed by piperacillin-tobramycin (9%), mezlocillin-tobramycin (6%), and piperacillin-gentamicin (5%). Antagonism for Enterobacteriaceae isolates was observed most frequently with the combination of piperacillin plus tobramycin (20%), followed by mezlocillin plus tobramycin (17.6%), piperacillin plus gentamicin (12.9%), and mezlocillin plus gentamicin (8.2%). There are very few differences in the activities of mezlocillin and piperacillin combined with either gentamicin or tobramycin versus nosocomial gram-negative bloodstream isolates. JF - American journal of infection control AU - Cabezudo, I AU - Pfaller, M A AU - Barrett, M AU - Bale, M AU - Wenzel, R P AD - Veterans Administration Medical Center, Iowa City, IA. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 250 EP - 256 VL - 18 IS - 4 SN - 0196-6553, 0196-6553 KW - Gentamicins KW - 0 KW - Mezlocillin KW - OH2O403D1G KW - Tobramycin KW - VZ8RRZ51VK KW - Piperacillin KW - X00B0D5O0E KW - Index Medicus KW - Hospitals, University KW - Humans KW - Drug Therapy, Combination -- pharmacology KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Piperacillin -- antagonists & inhibitors KW - Tobramycin -- antagonists & inhibitors KW - Tobramycin -- pharmacology KW - Mezlocillin -- pharmacology KW - Mezlocillin -- antagonists & inhibitors KW - Gram-Negative Bacteria -- drug effects KW - Piperacillin -- pharmacology KW - Gentamicins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80007670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=In+vitro+comparison+of+mezlocillin+and+piperacillin+plus+tobramycin+or+gentamicin+versus+100+gram-negative+nosocomial+bloodstream+isolates.&rft.au=Cabezudo%2C+I%3BPfaller%2C+M+A%3BBarrett%2C+M%3BBale%2C+M%3BWenzel%2C+R+P&rft.aulast=Cabezudo&rft.aufirst=I&rft.date=1990-08-01&rft.volume=18&rft.issue=4&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=01966553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-24 N1 - Date created - 1990-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The cocaine epidemic: treatment options for cocaine dependence. AN - 79997027; 2204847 AB - Because the current cocaine epidemic has affected all levels of health care, the primary care provider is increasingly called on to identify and treat the consequences of cocaine abuse and dependence. Therefore, a thorough understanding of the recovery process can enable the clinician to devise a treatment plan that coincides with rehabilitation efforts. This article presents an analysis of current management strategies for cocaine abuse and dependence. By incorporating the use of a health care model that addresses the five domains of health--physical, psychological, family/social, personal and spiritual--the clinician is in a better position to treat and refer the individual and family afflicted with the disease of cocaine addiction. A description of contemporary ongoing research is included to highlight future directions and possible modifications in treatment approaches for psychoactive substance-use disorder. JF - The Nurse practitioner AU - Chychula, N M AU - Okore, C AD - Philadelphia Veterans Administration Medical Center, Addictions Recovery Unit Pa. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 33 EP - 40 VL - 15 IS - 8 SN - 0361-1817, 0361-1817 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Nursing KW - Life Style KW - Nursing Assessment KW - Humans KW - Prognosis KW - Clinical Protocols KW - Substance-Related Disorders -- therapy KW - Health Promotion -- methods KW - Substance-Related Disorders -- nursing KW - Nurse Practitioners KW - Holistic Health KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79997027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=The+cocaine+epidemic%3A+treatment+options+for+cocaine+dependence.&rft.au=Chychula%2C+N+M%3BOkore%2C+C&rft.aulast=Chychula&rft.aufirst=N&rft.date=1990-08-01&rft.volume=15&rft.issue=8&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-12 N1 - Date created - 1990-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anticoagulation therapy: patient management and evaluation of an outpatient clinic. AN - 79995876; 2398969 AB - Health practitioners in the primary care setting often assess and manage patients on warfarin therapy. This article discusses new trends in oral anticoagulation and the latest indications for warfarin use. Patient management and education guidelines to improve patient care and compliance with warfarin therapy are reviewed. Results of a 19-month evaluative, retrospective, descriptive study of a nurse practitioner-run clinic are summarized. The results support that anticoagulation clinics managed by nurse practitioners are safe and effective. JF - The Nurse practitioner AU - Kornblit, P AU - Senderoff, J AU - Davis-Ericksen, M AU - Zenk, J AD - Veterans Administration Medical Center, Northport, N.Y. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 21 EP - 6, 29, 32 VL - 15 IS - 8 SN - 0361-1817, 0361-1817 KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - Nursing KW - Administration, Oral KW - Patient Education as Topic KW - New York KW - Humans KW - Nursing Evaluation Research KW - Aged KW - Male KW - Clinical Protocols KW - Hospitals, Veterans KW - Thromboembolism -- physiopathology KW - Thromboembolism -- nursing KW - Thromboembolism -- drug therapy KW - Outpatient Clinics, Hospital -- manpower KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - Outpatient Clinics, Hospital -- standards KW - Warfarin -- therapeutic use KW - Nurse Practitioners -- utilization KW - Nurse Practitioners -- standards KW - Outpatient Clinics, Hospital -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79995876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Anticoagulation+therapy%3A+patient+management+and+evaluation+of+an+outpatient+clinic.&rft.au=Kornblit%2C+P%3BSenderoff%2C+J%3BDavis-Ericksen%2C+M%3BZenk%2C+J&rft.aulast=Kornblit&rft.aufirst=P&rft.date=1990-08-01&rft.volume=15&rft.issue=8&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-12 N1 - Date created - 1990-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational sensitivity to Tenebrio molitor Linnaeus (yellow mealworm). AN - 79937368; 2384648 AB - Tenebrio molitor is an abundant stored-grain pest in the northern United States. We evaluated an individual with work-related symptoms of rhinoconjunctivitis on exposure to this insect. Prick skin tests with extracts prepared from the larval, pupal, and adult-life stages were positive for the patient and for another individual with allergy to a closely related species of beetle, Alphitobius diaperinus. Specific IgE antibodies to the extracts were demonstrated by RAST. RAST inhibition demonstrated immunologic cross-reactivity between the life stages of T. molitor and also between T. molitor and A. diaperinus, as well as slight cross-reactivity with blowfly. The proteins in the extracts of each life stage were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. More than 15 protein bands were detected in each of the extracts, although the patterns of separation were different for each life stage. After immunoblotting and autoradiography, six different IgE-binding proteins were identified in the larval extract, five in the pupal extract, and seven in the adult extract, with similar IgE-binding patterns noted for the larval and adult extracts. We conclude that this patient developed IgE-mediated sensitivity to T. molitor antigens as the result of occupational exposure. This study confirms the fact that beetles of the Tenebrionid family are potentially significant allergens for workers exposed to grains or grain products. JF - The Journal of allergy and clinical immunology AU - Schroeckenstein, D C AU - Meier-Davis, S AU - Bush, R K AD - Allergy Section, William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 182 EP - 188 VL - 86 IS - 2 SN - 0091-6749, 0091-6749 KW - Allergens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Arthropods -- immunology KW - Animals KW - Skin Tests KW - Humans KW - Adult KW - Animal Husbandry KW - Allergens -- analysis KW - Female KW - Cross Reactions KW - Occupational Diseases -- immunology KW - Hypersensitivity -- etiology KW - Tenebrio -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79937368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Occupational+sensitivity+to+Tenebrio+molitor+Linnaeus+%28yellow+mealworm%29.&rft.au=Schroeckenstein%2C+D+C%3BMeier-Davis%2C+S%3BBush%2C+R+K&rft.aulast=Schroeckenstein&rft.aufirst=D&rft.date=1990-08-01&rft.volume=86&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-20 N1 - Date created - 1990-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Allergens involved in occupational asthma caused by baby's breath (Gypsophila paniculata). AN - 79936704; 2384649 AB - Although the floral industry deals with many potential allergens, few examples of occupational asthma exist in this industry. A 22-year-old florist experienced symptoms of rhinitis, conjunctivitis, and asthma on exposure to baby's breath. To determine the contribution of baby's breath to the patient's symptoms, an extract of baby's breath was prepared. Prick skin tests with a 1:10(-5) wt/vol concentration of the extract produced an immediate response, whereas nonexposed atopic and normal control subjects did not react. The patient's asthmatic response to baby's breath was confirmed by bronchial challenge that caused an immediate fall in FEV1 of 26.2% from baseline after inhalation of 88 breath units of the extract. With a direct RAST, the patient's serum bound 38 times the amount of IgE bound by the negative control. IgE binding in the RAST was inhibited by the baby's breath extract but not by unrelated inhibitors (ragweed and tree pollens). Immunoblotting demonstrated IgE binding to 13 protein bands in the extract with molecular weights ranging from 11.5 to 68 kd. Serum from a patient previously reported to have sensitivity to baby's breath recognized five protein bands. Three proteins with molecular weights of 27, 31, and 37 kd were recognized by both patients' sera. We conclude that this patient developed IgE-mediated sensitivity to multiple allergens in baby's breath. This study confirms the importance of this plant as a potential cause of occupational asthma in the floral industry. JF - The Journal of allergy and clinical immunology AU - Schroeckenstein, D C AU - Meier-Davis, S AU - Yunginger, J W AU - Bush, R K AD - Allergy Section, William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 189 EP - 193 VL - 86 IS - 2 SN - 0091-6749, 0091-6749 KW - Allergens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Humans KW - Adult KW - Allergens -- analysis KW - Female KW - Asthma -- etiology KW - Occupational Diseases -- immunology KW - Plants -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79936704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Allergens+involved+in+occupational+asthma+caused+by+baby%27s+breath+%28Gypsophila+paniculata%29.&rft.au=Schroeckenstein%2C+D+C%3BMeier-Davis%2C+S%3BYunginger%2C+J+W%3BBush%2C+R+K&rft.aulast=Schroeckenstein&rft.aufirst=D&rft.date=1990-08-01&rft.volume=86&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-20 N1 - Date created - 1990-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancement of tumor necrosis factor-induced endothelial cell injury by cycloheximide. AN - 79927674; 2382730 AB - Tumor necrosis factor (TNF), a potent polypeptide mediator released by activated monocytes and macrophages, has a number of proinflammatory effects on endothelial cells. TNF is cytotoxic to tumor cells in vivo and in vitro, but TNF-induced toxicity to endothelial cells is less well established. We now report that cycloheximide (CHX), an inhibitor of protein synthesis, renders endothelial cells highly susceptible to TNF-induced lysis. TNF alone did not change the overall rate of protein synthesis by endothelial cells, whereas the addition of CHX completely abolished protein synthesis. Endothelial cells incubated in TNF alone in high concentrations (up to 1,000 U/ml) showed minimal rounding up and release of 51Cr. Likewise, CHX alone (5 micrograms/ml) had no significant effect on endothelial cell morphology and release of 51Cr. However, incubation of endothelial cells in both CHX and TNF caused injury in a dose-dependent manner. Morphological evidence of cell retraction, rounding, and detachment began within 2 h, but specific 51Cr release did not begin to rise until after 4 h. These changes were not observed when endothelial cells were incubated with TNF/CHX at 4 degrees C. The combination of TNF/CHX was lethal to all endothelial cells tested (bovine pulmonary artery, human umbilical vein, and human aorta), with human aortic cells showing the most pronounced changes. We conclude that healthy endothelial cells are resistant to TNF-induced lysis, but inhibition of their ability to make protein renders them highly susceptible. JF - The American journal of physiology AU - Nolop, K B AU - Ryan, U S AD - Veterans Administration Medical Center, Miami, Florida. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - L123 EP - L129 VL - 259 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Chromium Radioisotopes KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Cycloheximide KW - 98600C0908 KW - Leucine KW - GMW67QNF9C KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Pulmonary Artery KW - Cattle KW - Recombinant Proteins -- pharmacology KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Kinetics KW - Leucine -- metabolism KW - Drug Synergism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Cycloheximide -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79927674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Enhancement+of+tumor+necrosis+factor-induced+endothelial+cell+injury+by+cycloheximide.&rft.au=Nolop%2C+K+B%3BRyan%2C+U+S&rft.aulast=Nolop&rft.aufirst=K&rft.date=1990-08-01&rft.volume=259&rft.issue=2+Pt+1&rft.spage=L123&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-11 N1 - Date created - 1990-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence of clinically relevant bacteremia after upper gastrointestinal endoscopy in bone marrow transplant recipients. AN - 79925457; 2382662 AB - To determine the prevalence of clinically relevant bacteremia after upper endoscopy in patients undergoing bone marrow transplantation. We retrospectively reviewed the records of 151 patients who received an HLA-identical allogeneic bone marrow transplant (BMT) at the Seattle Veterans Affairs Medical Center between September 1983 and December 1988. Forty-seven patients who required esophago-gastroduodenoscopy (EGD) during their first 100 days after transplant were selected for evaluation. Clinically relevant bacteremia was defined as the development of hypotension, temperature greater than 38.5 degrees C, and a positive blood culture occurring within 24 hours after endoscopy. The presence of acute graft-versus-host disease (GVHD) at the time of endoscopy and the use of prednisone prior to endoscopy were considered possible risk factors for the development of bacteremia. The proportion of subjects who became bacteremic were compared using Fisher's exact test. Within 24 hours following endoscopy, nine patients (19%) developed clinically evident bacteremia (hypotension, temperature greater than 38.5 degrees C, and a positive blood culture). Eight of 14 patients receiving prednisone at the time of endoscopy developed bacteremia, compared to one of 33 not receiving prednisone (p less than 0.01). Nineteen patients had acute GVHD of at least grade 2 at the time of EGD, six of whom developed bacteremia. Although acute GVHD alone did not increase the risk of post-EGD bacteremia in patients not receiving prednisone (one of 21 versus zero of 12, p greater than 0.9), the risk of bacteremia was particularly high in patients with acute GVHD treated with prednisone at the time of EGD (six of seven). Allogeneic BMT recipients receiving prednisone for immunoprophylaxis after grafting or for treatment of acute GVHD are at high risk for clinically relevant bacteremia following EGD. Such patients are candidates for antibiotic prophylaxis prior to endoscopy. JF - The American journal of medicine AU - Bianco, J A AU - Pepe, M S AU - Higano, C AU - Applebaum, F R AU - McDonald, G B AU - Singer, J W AD - Marrow Transplant Unit, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 134 EP - 136 VL - 89 IS - 2 SN - 0002-9343, 0002-9343 KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Staphylococcal Infections -- epidemiology KW - Duodenoscopy KW - Gastroscopy KW - Prednisone -- adverse effects KW - Risk Factors KW - Humans KW - Retrospective Studies KW - Esophagoscopy KW - Prevalence KW - Graft vs Host Disease -- complications KW - Sepsis -- epidemiology KW - Endoscopy -- adverse effects KW - Bone Marrow Transplantation -- adverse effects KW - Sepsis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79925457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Prevalence+of+clinically+relevant+bacteremia+after+upper+gastrointestinal+endoscopy+in+bone+marrow+transplant+recipients.&rft.au=Bianco%2C+J+A%3BPepe%2C+M+S%3BHigano%2C+C%3BApplebaum%2C+F+R%3BMcDonald%2C+G+B%3BSinger%2C+J+W&rft.aulast=Bianco&rft.aufirst=J&rft.date=1990-08-01&rft.volume=89&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-12 N1 - Date created - 1990-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption. AN - 79914525; 2378542 AB - Depression and alcohol abuse have been associated with alterations in cell-mediated immune function. This study directly compared the effects of depression, alcoholism, and their joint contribution to reduce natural killer cell cytotoxicity. Natural killer cell activity was significantly lower in both depressed (n = 18) and alcoholic (n = 19) patients compared with control subjects (n = 50). In addition, patients with a dual diagnosis of either alcohol abuse and secondary depression (n = 9) or depression with a history of alcohol abuse (n = 26) demonstrated a further decrease in natural killer cell activity compared with that found in patients with either depression or alcoholism alone. While both depression and alcoholism are separately associated with a reduction of natural killer cell activity, subgroups of patients in whom the diagnoses of alcoholism and depression coexist show a further decrement in natural killer cell function. JF - Archives of general psychiatry AU - Irwin, M AU - Caldwell, C AU - Smith, T L AU - Brown, S AU - Schuckit, M A AU - Gillin, J C AD - Clinical Center for Research on Alcoholism, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 713 EP - 719 VL - 47 IS - 8 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Nutritional Status KW - Cytotoxicity, Immunologic KW - Educational Status KW - Age Factors KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Alcohol Drinking KW - Leukocyte Count KW - Depressive Disorder -- psychology KW - Depressive Disorder -- immunology KW - Alcoholism -- immunology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Killer Cells, Natural -- immunology KW - Depressive Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79914525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Major+depressive+disorder%2C+alcoholism%2C+and+reduced+natural+killer+cell+cytotoxicity.+Role+of+severity+of+depressive+symptoms+and+alcohol+consumption.&rft.au=Irwin%2C+M%3BCaldwell%2C+C%3BSmith%2C+T+L%3BBrown%2C+S%3BSchuckit%2C+M+A%3BGillin%2C+J+C&rft.aulast=Irwin&rft.aufirst=M&rft.date=1990-08-01&rft.volume=47&rft.issue=8&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4. AN - 79914448; 2379544 AB - A clonal marrow-adherent stromal cell line, +/+-1 LDA11, was derived and found to produce hemopoietic stimulatory activity for an interleukin 3 (IL-3)-dependent mast cell line, NFS/N1. This factor-dependent mast cell line displayed restricted growth factor responsiveness to only IL-3, interleukin 4 (IL-4), and the stromal cell-produced factor. The factor produced by stromal cells was distinguished from IL-3 and IL-4 and was characterized biochemically. This factor appears to be a novel mast cell growth factor (MCGF-3) capable of synergizing with IL-3 and IL-4. It may have broader reactivity in hemopoiesis than simply IL-3-dependent mast cells, and it may prove relevant to stromal cell-mediated hemopoiesis. JF - Experimental hematology AU - Boswell, H S AU - Mochizuki, D Y AU - Burgess, G S AU - Gillis, S AU - Walker, E B AU - Anderson, D AU - Williams, D E AD - Hematology/Oncology Division, Veterans Administration Medical Center, Indianapolis, Indiana. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 794 EP - 800 VL - 18 IS - 7 SN - 0301-472X, 0301-472X KW - Growth Substances KW - 0 KW - Interleukin-3 KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Bone Marrow Cells KW - Animals KW - Mice KW - Drug Synergism KW - Hematopoiesis KW - Cell Line KW - Cell Division KW - Cell Adhesion KW - Bone Marrow -- physiology KW - Interleukin-3 -- pharmacology KW - Growth Substances -- pharmacology KW - Interleukin-4 -- pharmacology KW - Mast Cells -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79914448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=A+novel+mast+cell+growth+factor+%28MCGF-3%29+produced+by+marrow-adherent+cells+that+synergizes+with+interleukin+3+and+interleukin+4.&rft.au=Boswell%2C+H+S%3BMochizuki%2C+D+Y%3BBurgess%2C+G+S%3BGillis%2C+S%3BWalker%2C+E+B%3BAnderson%2C+D%3BWilliams%2C+D+E&rft.aulast=Boswell&rft.aufirst=H&rft.date=1990-08-01&rft.volume=18&rft.issue=7&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-07 N1 - Date created - 1990-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - H(+)-induced vasodilation of rat aorta is mediated by alterations in intracellular calcium sequestration. AN - 79903454; 2115823 AB - Acidosis induces vasodilation both in vivo and in vitro. Although it is commonly surmised that acidosis alters contractility by affecting contractile proteins and calcium entry, the exact role of these mechanisms in acidosis-induced vasodilation has not been determined. In the present study, we demonstrated that a novel mechanism, involving increased calcium sequestration into intracellular sites sensitive to norepinephrine, mediates the vasodilation associated with relatively modest decreases in pH. The effects of changing pH from 7.4 to 7.0 on tension development, 45Ca fluxes, and the norepinephrine-releasable intracellular calcium stores were studied in isolated rat aorta. Acute acidification produced marked endothelium-independent dilations of aortic rings that had been precontracted with norepinephrine. In contrast, this maneuver had only modest effects on contractions elicited by 80 mM KCl or phorbol ester. Acidification in this range did not alter basal or norepinephrine-stimulated undirectional 45Ca influx, nor did it reduce the norepinephrine-induced net gain in 45Ca content. Furthermore, neither norepinephrine-stimulated 45Ca efflux nor the peak contractile response to norepinephrine in calcium-free buffer was affected, although in this setting, the duration of the phasic contractile response was shortened. When calcium was restored to tissues exposed to norepinephrine in calcium-free buffer, acidification slowed the rate of tension development without altering 45Ca uptake, thus changing the relation between tension development and calcium entry. These effects of acidification were shown to be associated with an increase in the amount of calcium sequestered into the norepinephrine-sensitive intracellular calcium store. These findings clearly indicate that acidification, within a range that has no effect on other aspects of smooth muscle activation, elicits vasodilation by stimulating intracellular calcium sequestration. This action may represent a predominant mechanism whereby acidosis alters vascular smooth muscle contractility. JF - Circulation research AU - Loutzenhiser, R AU - Matsumoto, Y AU - Okawa, W AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 426 EP - 439 VL - 67 IS - 2 SN - 0009-7330, 0009-7330 KW - Calcimycin KW - 37H9VM9WZL KW - Egtazic Acid KW - 526U7A2651 KW - Potassium Chloride KW - 660YQ98I10 KW - Acetylcholine KW - N9YNS0M02X KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Animals KW - Muscle, Smooth, Vascular -- physiology KW - Norepinephrine -- pharmacology KW - Hydrogen-Ion Concentration KW - Potassium Chloride -- pharmacology KW - Muscle, Smooth, Vascular -- drug effects KW - Acetylcholine -- pharmacology KW - Calcimycin -- pharmacology KW - Models, Biological KW - Rats, Inbred Strains KW - Rats KW - In Vitro Techniques KW - Muscle Contraction -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Egtazic Acid -- pharmacology KW - Calcium -- metabolism KW - Aorta, Thoracic -- drug effects KW - Acidosis -- physiopathology KW - Vasodilation KW - Aorta, Thoracic -- physiology KW - Calcium -- physiology KW - Aorta, Thoracic -- physiopathology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79903454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=H%28%2B%29-induced+vasodilation+of+rat+aorta+is+mediated+by+alterations+in+intracellular+calcium+sequestration.&rft.au=Loutzenhiser%2C+R%3BMatsumoto%2C+Y%3BOkawa%2C+W%3BEpstein%2C+M&rft.aulast=Loutzenhiser&rft.aufirst=R&rft.date=1990-08-01&rft.volume=67&rft.issue=2&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-06 N1 - Date created - 1990-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interferon-gamma inhibits 1,25-dihydroxyvitamin D3-stimulated synthesis of bone GLA protein in rat osteosarcoma cells by a pretranslational mechanism. AN - 79893918; 2115429 AB - Interferon-gamma (IFN) is produced by lymphocytes in areas of inflammation and connective tissue destruction. IFN inhibits collagen and DNA synthesis in cultured rat long bones and osteoblastic ROS 17/2.8 cells, suggesting that the periarticular loss of bone that occurs in inflammatory joint diseases may be due to IFN inhibition of bone formation. Since serum levels of bone gla protein (BGP) have been correlated with the bone formation rate, we studied the effect of IFN on production of this osteoblast-specific protein and steady state BGP messenger RNA (mRNA) levels in ROS 17/2.8 cells. RIA of BGP was done using an antibody raised against rat BGP peptide. BGP synthesis was stimulated with 10(-8) M 1,25-dihydroxyvitamin D3 24 h before and continuously after addition of recombinant rat IFN. IFN (100 U/ml) inhibited BGP secretion 52%, 78%, and 70% in the first, second, and third 24 h periods after IFN treatment, compared to control cells cultured with 1,25-dihydroxyvitamin D3 alone. The ED50 for IFN inhibition of BGP production was 3.3 U/ml (0.29 nM). Pulse labeling with [14C]leucine or [3H]proline during the last 4 h of culture revealed that IFN (3-100 U/ml) did not inhibit total protein secretion into the medium. The percent inhibition of BGP production by IFN was independent of media serum concentration or cell density. IFN (100 U/ml) decreased the steady state level of BGP mRNA as measured by Northern analysis using an oligomeric probe for rat BGP. The decrease in hybridization signal for BGP mRNA was detectable by 1 h after IFN exposure and continued to decline at 6 and 24 h. Treatment with cycloheximide (5 micrograms/ml) blocked the inhibitory effect of IFN on steady state levels of BGP mRNA. These results suggest that IFN may inhibit bone formation by selective inhibition of osteoblast matrix protein production. The mechanism of IFN inhibition of BGP production is, at least in part, pretranslational. JF - Endocrinology AU - Nanes, M S AU - Rubin, J AU - Titus, L AU - Hendy, G N AU - Catherwood, B D AD - Department of Medicine, Veterans Administration Medical Center, Atlanta, Georgia 30033. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 588 EP - 594 VL - 127 IS - 2 SN - 0013-7227, 0013-7227 KW - Culture Media KW - 0 KW - Neoplasm Proteins KW - Oligonucleotide Probes KW - Oligopeptides KW - RNA, Messenger KW - Recombinant Proteins KW - Osteocalcin KW - 104982-03-8 KW - Interferon-gamma KW - 82115-62-6 KW - Cycloheximide KW - 98600C0908 KW - Calcitriol KW - FXC9231JVH KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Neoplasm Proteins -- biosynthesis KW - Transcription, Genetic -- drug effects KW - Blotting, Northern KW - Amino Acid Sequence KW - RNA, Messenger -- genetics KW - Oligopeptides -- chemical synthesis KW - Rats KW - Base Sequence KW - Cycloheximide -- pharmacology KW - Kinetics KW - Molecular Sequence Data KW - Drug Synergism KW - RNA, Messenger -- isolation & purification KW - Tumor Cells, Cultured -- cytology KW - Tumor Cells, Cultured -- metabolism KW - Osteocalcin -- genetics KW - Tumor Cells, Cultured -- drug effects KW - Osteosarcoma -- metabolism KW - Interferon-gamma -- pharmacology KW - Osteocalcin -- biosynthesis KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79893918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Interferon-gamma+inhibits+1%2C25-dihydroxyvitamin+D3-stimulated+synthesis+of+bone+GLA+protein+in+rat+osteosarcoma+cells+by+a+pretranslational+mechanism.&rft.au=Nanes%2C+M+S%3BRubin%2C+J%3BTitus%2C+L%3BHendy%2C+G+N%3BCatherwood%2C+B+D&rft.aulast=Nanes&rft.aufirst=M&rft.date=1990-08-01&rft.volume=127&rft.issue=2&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-30 N1 - Date created - 1990-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanism of 12-O-tetradecanoylphorbol-13-acetate enhanced metabolism of arachidonic acid in dog urothelial cells. AN - 79871242; 2114944 AB - The mechanism of 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced arachidonic acid metabolism was investigated in dog urothelial cells. Primary cultures of dog urothelial cells were grown to confluency and evaluated in the presence or absence of overnight prelabeling with [3H]arachidonic acid. High-performance liquid chromatography analysis of media from TPA stimulated cells indicated that prostaglandin E2 (PGE2) was the major eicosanoid produced. Lipoxygenase products were not detected. Control cell media contained only arachidonic acid. Effects of selected inhibitors on TPA and exogenous arachidonic acid mediated increases in radioimmunoassayable PGE2 were assessed. Prostaglandin H synthase inhibitors (indomethacin and aspirin) prevented both TPA and arachidonic acid increases in PGE2. By contrast, inhibitors of phospholipases (quinacrine, W-7, and trifluoropromazine), protein synthesis (cycloheximide), and protein kinase C (staurosporine) prevented TPA but not arachidonic acid increases in PGE2. The latter agents also reduced TPA mediated increases in the release of total radioactivity from cells labeled with [3H]arachidonic acid. However, aspirin reduced the amount of 3H-prostaglandins formed with TPA. A calcium requirement was demonstrated when increases in radioimmunoassayable PGE2 elicited by TPA and the calcium ionophore A23187 were reduced with calcium depleted media. When epidermal growth factor in combination with either TPA or bradykinin was used, at least additive effects were observed with respect to release of [3H]arachidonic acid, 3H-prostaglandins, and radioimmunoassayable PGE2. These experiments suggest that separate pathways may be involved in enhanced arachidonic acid metabolism demonstrated with different agonists. For TPA, increased arachidonic acid release occurs by a calcium dependent process involving phospholipase(s), protein synthesis, and protein kinase C. JF - Cancer research AU - Zenser, T V AU - Eling, T E AU - Duniec, Z M AU - Wong, Y H AU - Davis, B B AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 4650 EP - 4655 VL - 50 IS - 15 SN - 0008-5472, 0008-5472 KW - Arachidonic Acids KW - 0 KW - Eicosanoids KW - Tritium KW - 10028-17-8 KW - Arachidonic Acid KW - 27YG812J1I KW - Epidermal Growth Factor KW - 62229-50-9 KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Bradykinin KW - S8TIM42R2W KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Dinoprostone -- biosynthesis KW - Calcium -- pharmacology KW - Epidermal Growth Factor -- pharmacology KW - Eicosanoids -- isolation & purification KW - Chromatography, High Pressure Liquid KW - Epithelium -- drug effects KW - Cells, Cultured KW - Dogs KW - Bradykinin -- pharmacology KW - Epithelium -- metabolism KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Urinary Bladder -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Arachidonic Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79871242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Mechanism+of+12-O-tetradecanoylphorbol-13-acetate+enhanced+metabolism+of+arachidonic+acid+in+dog+urothelial+cells.&rft.au=Zenser%2C+T+V%3BEling%2C+T+E%3BDuniec%2C+Z+M%3BWong%2C+Y+H%3BDavis%2C+B+B&rft.aulast=Zenser&rft.aufirst=T&rft.date=1990-08-01&rft.volume=50&rft.issue=15&rft.spage=4650&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-23 N1 - Date created - 1990-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Possible atrial proarrhythmic effects of class 1C antiarrhythmic drugs. AN - 79868684; 2114784 JF - The American journal of cardiology AU - Feld, G K AU - Chen, P S AU - Nicod, P AU - Fleck, R P AU - Meyer, D AD - Veterans Administration Medical Center, La Jolla, California. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 378 EP - 383 VL - 66 IS - 3 SN - 0002-9149, 0002-9149 KW - Anilides KW - 0 KW - Anti-Arrhythmia Agents KW - Flecainide KW - K94FTS1806 KW - Encainide KW - SY3J0147NB KW - Abridged Index Medicus KW - Index Medicus KW - Anilides -- therapeutic use KW - Humans KW - Flecainide -- therapeutic use KW - Flecainide -- adverse effects KW - Electrocardiography KW - Anilides -- adverse effects KW - Aged KW - Male KW - Female KW - Tachycardia, Supraventricular -- chemically induced KW - Atrial Flutter -- chemically induced KW - Atrial Flutter -- diagnosis KW - Tachycardia, Supraventricular -- diagnosis KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79868684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Possible+atrial+proarrhythmic+effects+of+class+1C+antiarrhythmic+drugs.&rft.au=Feld%2C+G+K%3BChen%2C+P+S%3BNicod%2C+P%3BFleck%2C+R+P%3BMeyer%2C+D&rft.aulast=Feld&rft.aufirst=G&rft.date=1990-08-01&rft.volume=66&rft.issue=3&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-16 N1 - Date created - 1990-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rationale against the drug treatment of marginal diastolic systemic hypertension. AN - 79864291; 2195866 JF - The American journal of cardiology AU - Freis, E D AD - Hypertension Clinic, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1990/08/01/ PY - 1990 DA - 1990 Aug 01 SP - 368 EP - 371 VL - 66 IS - 3 SN - 0002-9149, 0002-9149 KW - Antihypertensive Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Coronary Disease -- mortality KW - Diastole -- drug effects KW - Costs and Cost Analysis KW - Coronary Disease -- complications KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Hypertension -- complications KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79864291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Rationale+against+the+drug+treatment+of+marginal+diastolic+systemic+hypertension.&rft.au=Freis%2C+E+D&rft.aulast=Freis&rft.aufirst=E&rft.date=1990-08-01&rft.volume=66&rft.issue=3&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-16 N1 - Date created - 1990-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Cardiol 1990 Dec 1;66(19):1401 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anti-proliferative effects of tumor necrosis factor, gamma interferon and 5-fluorouracil on human colorectal carcinoma cell lines. AN - 79861232; 2114374 AB - We have previously utilized a bank of diverse human colorectal carcinoma cell lines to assess the synergistic antiproliferative effect of tumor necrosis factor (TNF) and IFN-gamma (IFN-gamma) in combination. In this study, we used 3 of these cell lines (HCT 116, SKO1 and VACO 9P) to study the growth-inhibitory effects of TNF and IFN-gamma (TNF/IFN-gamma) on these cells when administered in conjunction with 5-fluorouracil (5-FU). All 3 cell lines were sensitive to suprapharmacologic concentrations of 5-FU. However, the 3 lines varied in their sensitivities to clinically achievable concentrations of 5-FU. Concentrations of 0.1 microgram/ml of 5-FU administered for 96 hr, and 50 micrograms/ml administered for 1 hr, inhibited the growth of HCT 116 cells by 20% and 77%, that of SKCO1 cells by 25% and 66%, and that of VACO 9P cells by 25% and 55%, respectively. All 3 cell lines were sensitive to the anti-proliferative effects of TNF/IFN-gamma in a dose-dependent and duration-dependent fashion. TNF/IFN-gamma was administered for 1 hr every other day on days 1, 3 and 5 to the 3 cell lines. Cells were also exposed to 5-FU, administered either concomitantly for 96 hr, or for 1 hr on day 1. The addition of TNF/IFN-gamma to clinically achievable concentrations of 5-FU in both schedules resulted in additive cytotoxicity. For example, the addition of 10 ng/ml of both TNF and IFN-gamma to 96 hr of 0.1 microgram/ml 5-FU resulted in 10%, 5%, and 20% of control growth for the HCT 116 cell line, SKCO1 cell line, and VACO 9P cell line, respectively. The addition of 10 ng/ml of both TNF and IFN-gamma to 1 hr of 50 micrograms/ml of 5-FU inhibited all cell growth in all 3 cell lines. We conclude that TNF/IFN-gamma and 5-FU can be combined to achieve higher anti-tumor activity than either 5-FU or TNF/IFN-gamma alone in this in vitro model, that the 3-drug combination has potent growth-inhibitory effects at pharmacologic concentrations which are not schedule-dependent, and that this combination warrants further study in clinical trials. JF - International journal of cancer AU - Schiller, J H AU - Bittner, G AD - William S. Middleton Memorial Veterans Administration Hospital, Madison, WI 53792. Y1 - 1990/07/15/ PY - 1990 DA - 1990 Jul 15 SP - 61 EP - 66 VL - 46 IS - 1 SN - 0020-7136, 0020-7136 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Interferon-gamma KW - 82115-62-6 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Tumor Cells, Cultured -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Division -- drug effects KW - Tumor Cells, Cultured -- pathology KW - Drug Synergism KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Time Factors KW - Cell Line KW - Fluorouracil -- therapeutic use KW - Carcinoma -- pathology KW - Interferon-gamma -- therapeutic use KW - Colorectal Neoplasms -- pathology KW - Carcinoma -- drug therapy KW - Tumor Necrosis Factor-alpha -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79861232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Anti-proliferative+effects+of+tumor+necrosis+factor%2C+gamma+interferon+and+5-fluorouracil+on+human+colorectal+carcinoma+cell+lines.&rft.au=Schiller%2C+J+H%3BBittner%2C+G&rft.aulast=Schiller&rft.aufirst=J&rft.date=1990-07-15&rft.volume=46&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-16 N1 - Date created - 1990-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Deep Dysphasia: Analysis of a Rare Form of Repetition Disorder AN - 85520434; 9102174 AB - The case history is reported of a patient exhibiting a disorder of repetition characterized by the production of errors that are real words semantically or phonologically related to the target word. This syndrome has been labeled "deep dysphasia" due to its similarity to the oral reading performance of deep dyslexics. The observed symptoms provide support for models that posit the existence of separate systems for reading & repetition, each having three routes: nonlexical, lexical with semantic mediation, & lexical without semantic mediation. Repetition performance of this patient is documented, & results are reported of experimental studies of ability to repeat abstract & concrete words, words of different grammatical classes, suffixed words, words varying in frequency & length, & nonwords. Findings suggest that both the nonsemantic-lexical route & the nonlexical route are impaired in this patient, & that the semantic-lexical route is unreliable due to faulty semantic processing. 7 Tables, 36 References. B. Annesser Murray JF - Brain and Language AU - Katz, Robert B AU - Goodglass, Harold AD - Aphasia Research Center Veterans Administration Medical Center, Boston MA 02130 Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 153 EP - 185 VL - 39 IS - 1 SN - 0093-934X, 0093-934X KW - deep dysphasia characterization, repetition disorders KW - case study KW - Cognitive Processes (co1b) KW - Language Pathology (la4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85520434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Deep+Dysphasia%3A+Analysis+of+a+Rare+Form+of+Repetition+Disorder&rft.au=Katz%2C+Robert+B%3BGoodglass%2C+Harold&rft.aulast=Katz&rft.aufirst=Robert&rft.date=1990-07-01&rft.volume=39&rft.issue=1&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Cognitive Processes (co1b) ER - TY - JOUR T1 - Nonclosure of pharyngeal muscle after laryngectomy. AN - 85297407; pmid-2195956 AB - A prospective study was carried out to evaluate a new technique of pharyngeal repair following laryngectomy. The purpose of this study was to see whether satisfactory healing would occur if the pharyngeal constrictors were not sutured across the closure in the pharynx. If healing proved to be satisfactory the procedure might eliminate the need for primary or secondary myotomy or pharyngeal plexus neurectomy to facilitate tracheoesophageal speech. The results indicate that healing is as good in the group who did not have muscle closure as in those who did. JF - The Annals of Otology, Rhinology, and Laryngology AU - Olson, N R AU - Callaway, E AD - Otolaryngology Service, Veterans Administration Medical Center, Ann Arbor, Michigan. PY - 1990 SP - 507 EP - 508 VL - 99 IS - 7 Pt 1 SN - 0003-4894, 0003-4894 KW - Feasibility Studies KW - Comparative Study KW - Evaluation Studies KW - Prospective Studies KW - Pharyngeal Muscles KW - Humans KW - Laryngectomy KW - Muscles KW - Suture Techniques KW - Pharyngeal Diseases KW - Fistula UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85297407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Nonclosure+of+pharyngeal+muscle+after+laryngectomy.&rft.au=Olson%2C+N+R%3BCallaway%2C+E&rft.aulast=Olson&rft.aufirst=N&rft.date=1990-07-01&rft.volume=99&rft.issue=7+Pt+1&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Obstructive disordered breathing during sleep in patients with spinal cord injury. AN - 80099839; 2235050 AB - Little is known about respiration and sleep in spinal cord injured (SCI) patients, and yet they frequently have complaints related to sleep. Four SCI patients with various sleep complaints were evaluated with nocturnal polysomnography. All 4 had evidence of obstructive sleep apnea (disordered breathing). These findings suggest that obstructive sleep apnea may be contributing to disruptive sleep in SCI patients and may be responsible for many of their daytime symptoms. JF - Paraplegia AU - Bonekat, H W AU - Andersen, G AU - Squires, J AD - Department of Pulmonary Medicine, Salt Lake City, Veterans Administration Medical Center, Utah. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 392 EP - 398 VL - 28 IS - 6 SN - 0031-1758, 0031-1758 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Sleep, REM KW - Respiratory Function Tests KW - Oxygen -- blood KW - Humans KW - Supination KW - Adult KW - Nervous System -- physiopathology KW - Aged KW - Middle Aged KW - Respiratory Muscles -- innervation KW - Male KW - Spinal Cord Injuries -- complications KW - Sleep Apnea Syndromes -- chemically induced KW - Sleep Apnea Syndromes -- etiology KW - Spinal Cord Injuries -- drug therapy KW - Spinal Cord Injuries -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80099839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paraplegia&rft.atitle=Obstructive+disordered+breathing+during+sleep+in+patients+with+spinal+cord+injury.&rft.au=Bonekat%2C+H+W%3BAndersen%2C+G%3BSquires%2C+J&rft.aulast=Bonekat&rft.aufirst=H&rft.date=1990-07-01&rft.volume=28&rft.issue=6&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Paraplegia&rft.issn=00311758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-06 N1 - Date created - 1990-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Asbestos bodies in pulmonary hilar lymph nodes. AN - 80054208; 2217155 AB - Asbestos bodies (AB) have long been recognized in light microscopic (LM) sections of pulmonary hilar lymph nodes (LN) from patients with asbestos-related diseases, but the presence of AB on LM has not been correlated with the lung AB burden. The purpose of the present study was to determine whether AB in histologic sections of LN are indicative of heavy lung asbestos burdens. Twenty cases (17 with asbestosis, 15 with carcinoma of the lung, and two with malignant pleural mesothelioma) with at least one AB on a hilar LN section were identified. Bleach digestion of lung tissue in 15 cases demonstrated a median of 24,000 AB/g by LM and 44,000 AB/g by scanning electron microscopy. Digestion of hilar nodes demonstrated 21,800, 15,500, and 3,200 AB/g by LM in three cases which had lung burdens of 22,000, 481,000, and 5470 AB/g, respectively. A fourth LN specimen contained 322,000 AB/g in a case with no lung available to digest. Mean AB lengths in the LN in three cases were 48, 45, and 27 microns. Fourteen control cases of men over 50 without known asbestos exposure or asbestos-related disease had no AB in LN sections even after staining for iron. Among fourteen patients with parietal pleural plaques and an elevated lung asbestos body content, AB were observed in iron-stained LN sections in only two cases. These two patients had 3240 and 610 AB/g lung tissue, respectively (normal range 0 to 20 AB/g). We conclude that the finding of AB on a histologic section of hilar LN is generally indicative of a heavy lung AB burden.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc AU - Roggli, V L AU - Benning, T L AD - Department of Pathology, Durham Veterans Administration Medical Center, North Carolina. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 513 EP - 517 VL - 3 IS - 4 SN - 0893-3952, 0893-3952 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Mesothelioma -- etiology KW - Pleural Neoplasms -- pathology KW - Aged KW - Asbestosis -- etiology KW - Lung Neoplasms -- etiology KW - Asbestosis -- pathology KW - Mesothelioma -- pathology KW - Middle Aged KW - Pleural Neoplasms -- etiology KW - Female KW - Male KW - Lung Neoplasms -- pathology KW - Microscopy, Electron, Scanning KW - Lymph Nodes -- pathology KW - Asbestos -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80054208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.atitle=Asbestos+bodies+in+pulmonary+hilar+lymph+nodes.&rft.au=Roggli%2C+V+L%3BBenning%2C+T+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1990-07-01&rft.volume=3&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.issn=08933952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-31 N1 - Date created - 1990-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The construct validity of an aftereffect-based subtyping system for alcoholics. AN - 80032108; 2212056 AB - In an earlier project, we identified five alcohol-consumption aftereffect factors, which were named Hangover, Euphoria, Flushing, Seizures, and Sleepiness. In this study (N = 100) we assessed the construct validities of the five, using 47 MMPI, self-report, and recidivism criteria. The number of significant relationships between the factors and the criteria substantially exceeded chance. The Hangover factor related to social maladjustment and to the MMPI Psychopathic Deviate, Paranoia, Psychasthenia, Hypomania, and Masculinity-Femininity scales. The Euphoria factor was associated with a high number of job losses, but a low incidence of certain physical sequelae. The Flushing factor was associated with high consumption, late development of alcoholism, many physical complaints, and older age. The Seizure factor correlated with high consumption, facial puffiness, tremors, and lack of defensiveness on the MMPI. The Sleepiness factor was associated with a good prognosis and several mild MMPI elevations. These findings suggest that the factors may provide the basis for a useful alcoholism subtyping system and that additional research on them should prove fruitful. JF - Journal of clinical psychology AU - Watson, C G AU - Tilleskjor, C AU - Jacobs, L AD - Veterans Administration Medical Center, St. Cloud, Minnesota. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 507 EP - 517 VL - 46 IS - 4 SN - 0021-9762, 0021-9762 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Alcoholic Intoxication -- psychology KW - Risk Factors KW - Humans KW - MMPI KW - Adult KW - Middle Aged KW - Personality Development KW - Recurrence KW - Male KW - Alcoholism -- rehabilitation KW - Ethanol -- adverse effects KW - Arousal -- drug effects KW - Veterans -- psychology KW - Alcohol Drinking -- psychology KW - Substance Withdrawal Syndrome -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80032108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=The+construct+validity+of+an+aftereffect-based+subtyping+system+for+alcoholics.&rft.au=Watson%2C+C+G%3BTilleskjor%2C+C%3BJacobs%2C+L&rft.aulast=Watson&rft.aufirst=C&rft.date=1990-07-01&rft.volume=46&rft.issue=4&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-19 N1 - Date created - 1990-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations. AN - 79967988; 2202751 AB - Amiodarone, an iodinated benzofuran derivative, is used for treatment of refractory cardiac arrhythmias. Certain features of the drug's structure resemble those of the biologically active thyroid hormone, triiodothyronine (T3). In addition, the drug has a variety of complex effects on thyroid hormone physiology, including a number of possible antagonistic effects on thyroid hormone function at the cellular level. The drug occasionally causes clinically overt hyperthyroidism and hypothyroidism. We review these effects and discuss their clinical implications. JF - Journal of clinical pharmacology AU - Figge, H L AU - Figge, J AD - Department of Pharmacy, Albany Veterans Administration Medical Center, NY. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 588 EP - 595 VL - 30 IS - 7 SN - 0091-2700, 0091-2700 KW - Triiodothyronine KW - 06LU7C9H1V KW - Amiodarone KW - N3RQ532IUT KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Myocardium -- cytology KW - Chemistry KW - Humans KW - Chemical Phenomena KW - Thyroid Function Tests KW - Hyperthyroidism -- diagnosis KW - Hyperthyroidism -- drug therapy KW - Triiodothyronine -- antagonists & inhibitors KW - Triiodothyronine -- blood KW - Hypothyroidism -- drug therapy KW - Hypothyroidism -- chemically induced KW - Thyroxine -- blood KW - Hyperthyroidism -- chemically induced KW - Amiodarone -- pharmacology KW - Thyroid Gland -- physiology KW - Thyroid Gland -- drug effects KW - Thyroxine -- antagonists & inhibitors KW - Hypothyroidism -- diagnosis KW - Amiodarone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79967988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=The+effects+of+amiodarone+on+thyroid+hormone+function%3A+a+review+of+the+physiology+and+clinical+manifestations.&rft.au=Figge%2C+H+L%3BFigge%2C+J&rft.aulast=Figge&rft.aufirst=H&rft.date=1990-07-01&rft.volume=30&rft.issue=7&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-04 N1 - Date created - 1990-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypodermic needle embolization to the heart. AN - 79939756; 2385390 JF - New York state journal of medicine AU - Stern, M F AU - Steinbach, B G AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, NY. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 368 EP - 371 VL - 90 IS - 7 SN - 0028-7628, 0028-7628 KW - Index Medicus KW - Humans KW - Adult KW - Substance Abuse, Intravenous -- complications KW - Male KW - Heart KW - Embolism -- etiology KW - Foreign Bodies -- etiology KW - Foreign Bodies -- complications KW - Heart Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79939756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+York+state+journal+of+medicine&rft.atitle=Hypodermic+needle+embolization+to+the+heart.&rft.au=Stern%2C+M+F%3BSteinbach%2C+B+G&rft.aulast=Stern&rft.aufirst=M&rft.date=1990-07-01&rft.volume=90&rft.issue=7&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=New+York+state+journal+of+medicine&rft.issn=00287628&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-18 N1 - Date created - 1990-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Y State J Med. 1990 Jul;90(7):347-8 [2385386] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Resolution of acute renal failure in toxoplasmic encephalitis despite continuance of sulfadiazine. AN - 79939600; 2385768 AB - A patient with AIDS and toxoplasmic encephalitis treated with pyrimethamine and sulfadiazine became hypovolemic and developed acute renal failure. Diagnostic sulfadiazine crystals were abundant in the urine, and ultrasound examination demonstrated sludge and stones, presumably due to sulfadiazine. Renal failure resolved rapidly with hydration and administration of alkali, despite continued administration of sulfadiazine. The relatively old literature concerning crystalluria and renal failure due to sulfonamides is reviewed briefly, since complications due to use of poorly soluble sulfonamides probably will become more widespread as toxoplasmic encephalitis becomes more prevalent. JF - Reviews of infectious diseases AU - Oster, S AU - Hutchison, F AU - McCabe, R AD - Medical Service, Martinez Veterans Administration Medical Center, Martinez, California. PY - 1990 SP - 618 EP - 620 VL - 12 IS - 4 SN - 0162-0886, 0162-0886 KW - Sulfadiazine KW - 0N7609K889 KW - Index Medicus KW - AIDS/HIV KW - Fluid Therapy KW - Humans KW - Adult KW - Male KW - Acquired Immunodeficiency Syndrome -- complications KW - Toxoplasmosis -- complications KW - Sulfadiazine -- therapeutic use KW - Encephalitis -- drug therapy KW - Acute Kidney Injury -- chemically induced KW - Sulfadiazine -- adverse effects KW - Encephalitis -- parasitology KW - Acute Kidney Injury -- therapy KW - Encephalitis -- complications KW - Toxoplasmosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79939600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Resolution+of+acute+renal+failure+in+toxoplasmic+encephalitis+despite+continuance+of+sulfadiazine.&rft.au=Oster%2C+S%3BHutchison%2C+F%3BMcCabe%2C+R&rft.aulast=Oster&rft.aufirst=S&rft.date=1990-07-01&rft.volume=12&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-17 N1 - Date created - 1990-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of prolonged ethanol intake on pancreatic lipids in the rat pancreas. AN - 79929120; 2381900 AB - Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wayne Rodent-Blox ad libitum or Lieber-DeCarli diet with 36% of maltose dextrin calories replaced with ethanol ad libitum, or isocaloric amounts of liquid diet for a period of 21 months resulting in changes of chronic pancreatitis in ethanol-fed rats. A low level of triglycerides, a high level of cholesterol ester and moderately elevated phospholipids, low incorporation of [14C]palmitoyl in triglycerides, increased 14C activity in phospholipids, and cholesterol ester were found by thin-layer chromatography in ethanol-fed rats. These data indicate that the pancreas synthesized triglycerides and other lipid components in the same way as liver and fat cells. Chronic ethanol ingestion caused marked changes in pancreatic lipid metabolism due to altered enzyme activities involved in the lipid pathways. JF - Pancreas AU - Simsek, H AU - Singh, M AD - Pancreatic Research Laboratory, Veterans Administration Medical Center, Augusta, GA 30910. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 401 EP - 407 VL - 5 IS - 4 SN - 0885-3177, 0885-3177 KW - Cholesterol Esters KW - 0 KW - Phospholipids KW - Triglycerides KW - Palmitoyl Coenzyme A KW - 1763-10-6 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Nutritional Status KW - Animals KW - Phospholipids -- metabolism KW - Energy Intake KW - Palmitoyl Coenzyme A -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Pancreatitis -- pathology KW - Cholesterol Esters -- metabolism KW - Triglycerides -- metabolism KW - Chronic Disease KW - Microscopy, Electron KW - Female KW - Pancreatitis -- chemically induced KW - Ethanol -- pharmacology KW - Pancreas -- metabolism KW - Ethanol -- administration & dosage KW - Alcoholism -- metabolism KW - Pancreas -- ultrastructure KW - Pancreas -- drug effects KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79929120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pancreas&rft.atitle=Effect+of+prolonged+ethanol+intake+on+pancreatic+lipids+in+the+rat+pancreas.&rft.au=Simsek%2C+H%3BSingh%2C+M&rft.aulast=Simsek&rft.aufirst=H&rft.date=1990-07-01&rft.volume=5&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Pancreas&rft.issn=08853177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-12 N1 - Date created - 1990-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Screening elderly veterans for alcoholism. AN - 79894505; 2374046 AB - To determine the sensitivity and specificity of an alcoholism screening test not previously tested in the elderly. Cross-sectional study, face-to-face interviews. Veterans Administration (VA) outpatient facility. Men greater than or equal to 70 years old seeking care in a newly established VA outpatient facility were invited to participate in a health assessment program. Of 109 participants who enrolled, 96 completed both interviews. The screening test was administered by an internist as part of a medical history. The Michigan Alcoholism Screening Test (MAST), used as the "gold standard," was administered by a trained interviewer as part of a longer structured interview. The screening test had a sensitivity of 0.52 and a specificity of 0.76 in this sample. The sensitivity and specificity of the screening test were lower in this sample in comparison with previously reported results in a younger population. Differences in the test performance may be related to differences in attitudes and drinking behaviors of elderly veterans when compared with those of younger men and women. JF - Journal of general internal medicine AU - Moran, M B AU - Naughton, B J AU - Hughes, S L AD - Veterans Administration Lakeside Medical Center, Evanston, Illinois. PY - 1990 SP - 361 EP - 364 VL - 5 IS - 4 SN - 0884-8734, 0884-8734 KW - Index Medicus KW - Age Factors KW - Humans KW - Aged KW - Predictive Value of Tests KW - Medical History Taking KW - Ambulatory Care KW - False Positive Reactions KW - Evaluation Studies as Topic KW - False Negative Reactions KW - Cross-Sectional Studies KW - Illinois -- epidemiology KW - Aged, 80 and over KW - Female KW - Male KW - Veterans KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79894505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Screening+elderly+veterans+for+alcoholism.&rft.au=Moran%2C+M+B%3BNaughton%2C+B+J%3BHughes%2C+S+L&rft.aulast=Moran&rft.aufirst=M&rft.date=1990-07-01&rft.volume=5&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=08848734&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-27 N1 - Date created - 1990-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Update on topical cyclosporin A. Background, immunology, and pharmacology. AN - 79892403; 2197063 AB - Systemic cyclosporin A (CsA) is currently being used for immunosuppression in solid organ transplantation. Its unique mechanism of action and low myelotoxicity have vastly improved the prognosis for patient survival. A reversible and irreversible nephrotoxicity has complicated its use. CsA works via the inhibition of both lymphokine release and subsequent activation of cytotoxic T cells. The corneal allograft model presents several unique features that make it amenable to local immunosuppressant therapy. Following topical application, CsA corneal levels have been obtained above the experimentally determined levels necessary for local immunosuppression. CsA represents one of a new class of specific, potent immunomodulators, which may improve the prognosis for patients at high risk for allograft rejection. JF - Cornea AU - Belin, M W AU - Bouchard, C S AU - Phillips, T M AD - Department of Ophthalmology, Albany Medical College, Albany Veterans Administration Hospital, New York 12203. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 184 EP - 195 VL - 9 IS - 3 SN - 0277-3740, 0277-3740 KW - Cyclosporins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Eye -- drug effects KW - Models, Biological KW - Administration, Topical KW - Cyclosporins -- adverse effects KW - Cyclosporins -- blood KW - Corneal Transplantation -- immunology KW - Graft Rejection -- drug effects KW - Cyclosporins -- pharmacology KW - Cyclosporins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79892403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=Update+on+topical+cyclosporin+A.+Background%2C+immunology%2C+and+pharmacology.&rft.au=Belin%2C+M+W%3BBouchard%2C+C+S%3BPhillips%2C+T+M&rft.aulast=Belin&rft.aufirst=M&rft.date=1990-07-01&rft.volume=9&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=02773740&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-30 N1 - Date created - 1990-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative effects of phenytoin and/or phenobarbital treatment on sister chromatid exchange. AN - 79875211; 2369879 AB - The potential of the widely prescribed antiepileptic drugs (AEDs) phenytoin (PHT) and phenobarbital (PB) to interact with genetic material was tested using sister chromatid exchange (SCE) assay. Thirty adult male patients with epilepsy receiving long-term AED therapy (16 with PHT, 6 with PB, and 8 with combined PHT and PB therapy) and 30 healthy controls were selected for the study of SCE frequencies in peripheral lymphocytes. The patients and controls were carefully screened and matched for sex, age, and smoking habits. All potential probands with exposure to factors known or suspected of affecting the SCE frequencies were excluded. Statistical analyses did not show any significant differences between the SCE rates of PHT- and/or PB-treated patients and controls, indicating a lack of mutagenicity of the tested drugs as expressed by induction of SCE on adult recipients. Smoking, however, affected the SCE levels considerably. The smokers had higher SCE frequencies than the nonsmokers, both among patients and controls. Caffeine consumption was also associated with SCE increases in patients but not in controls. JF - Epilepsia AU - Schaumann, B A AU - Winge, V B AU - Pederson, M AU - Kuskowski, M A AD - Research Service, Veterans Administration Medical Center, Portland, OR 97207. PY - 1990 SP - 453 EP - 457 VL - 31 IS - 4 SN - 0013-9580, 0013-9580 KW - Anticonvulsants KW - 0 KW - Phenytoin KW - 6158TKW0C5 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Anticonvulsants -- pharmacology KW - Phenytoin -- pharmacology KW - Phenobarbital -- pharmacology KW - Epilepsy -- genetics KW - Sister Chromatid Exchange -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79875211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Comparative+effects+of+phenytoin+and%2For+phenobarbital+treatment+on+sister+chromatid+exchange.&rft.au=Schaumann%2C+B+A%3BWinge%2C+V+B%3BPederson%2C+M%3BKuskowski%2C+M+A&rft.aulast=Schaumann&rft.aufirst=B&rft.date=1990-07-01&rft.volume=31&rft.issue=4&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-21 N1 - Date created - 1990-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contamination of enteral feedings and diarrhea in patients in intensive care units. AN - 79874343; 2115031 AB - To investigate the effect of contamination of enteral feeding solutions on the incidence of diarrhea in critically ill patients, 36 adult intensive and coronary care unit patients received enteral feeding by an aseptic or a routine protocol. Cultures of formula were obtained on the first 4 days of enteral feeding. A significantly greater incidence of contamination was found for the routine protocol group than for the aseptic protocol group (p less than 0.05); however, differences in incidence of diarrhea between subjects who did and did not receive contaminated formula were not significant. Subjects who had diarrhea also had significantly lower (p less than 0.05) serum albumin and transferrin levels. The effects of severity of illness, osmolality, and rate of formula administration on incidence of diarrhea were investigated, and these were not found to be significant factors. Implications for nursing practice and further research are generated. JF - Heart & lung : the journal of critical care AU - Mickschl, D B AU - Davidson, L J AU - Flournoy, D J AU - Parker, D E AD - University of Oklahoma College of Nursing, College of Medicine, Veterans Administration Medical Center. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 362 EP - 370 VL - 19 IS - 4 SN - 0147-9563, 0147-9563 KW - Serum Albumin KW - 0 KW - Transferrin KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Serum Albumin -- analysis KW - Antisepsis KW - Humans KW - Aged KW - Bacteria -- isolation & purification KW - Transferrin -- analysis KW - Aged, 80 and over KW - Adult KW - Intensive Care Units KW - Middle Aged KW - Female KW - Male KW - Diarrhea -- blood KW - Food Microbiology KW - Enteral Nutrition -- nursing KW - Enteral Nutrition -- adverse effects KW - Diarrhea -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79874343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+%26+lung+%3A+the+journal+of+critical+care&rft.atitle=Contamination+of+enteral+feedings+and+diarrhea+in+patients+in+intensive+care+units.&rft.au=Mickschl%2C+D+B%3BDavidson%2C+L+J%3BFlournoy%2C+D+J%3BParker%2C+D+E&rft.aulast=Mickschl&rft.aufirst=D&rft.date=1990-07-01&rft.volume=19&rft.issue=4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Heart+%26+lung+%3A+the+journal+of+critical+care&rft.issn=01479563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-23 N1 - Date created - 1990-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spurious hyperchloremia and hyperbicarbonatemia in a patient receiving pyridostigmine bromide therapy for myasthenia gravis. AN - 79868955; 2368710 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Wacks, I AU - Oster, J R AU - Pérez, G O AU - Kett, D H AD - Medical Service, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 76 EP - 79 VL - 16 IS - 1 SN - 0272-6386, 0272-6386 KW - Bicarbonates KW - 0 KW - Chlorides KW - Pyridostigmine Bromide KW - KVI301NA53 KW - Index Medicus KW - Humans KW - Middle Aged KW - Chlorides -- blood KW - Female KW - Bicarbonates -- blood KW - Acid-Base Equilibrium -- drug effects KW - Myasthenia Gravis -- drug therapy KW - Pyridostigmine Bromide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79868955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Spurious+hyperchloremia+and+hyperbicarbonatemia+in+a+patient+receiving+pyridostigmine+bromide+therapy+for+myasthenia+gravis.&rft.au=Wacks%2C+I%3BOster%2C+J+R%3BP%C3%A9rez%2C+G+O%3BKett%2C+D+H&rft.aulast=Wacks&rft.aufirst=I&rft.date=1990-07-01&rft.volume=16&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dialysis acne. AN - 79863796; 2142170 JF - Journal of the American Academy of Dermatology AU - Fuchs, E AU - Lynfield, Y AD - Dermatology Service, Brooklyn Veterans Administration Medical Center, New York. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 125 VL - 23 IS - 1 SN - 0190-9622, 0190-9622 KW - Testosterone KW - 3XMK78S47O KW - testosterone enanthate KW - 7Z6522T8N9 KW - Index Medicus KW - Testosterone -- analogs & derivatives KW - Humans KW - Testosterone -- adverse effects KW - Kidney Failure, Chronic -- therapy KW - Middle Aged KW - Male KW - Acne Vulgaris -- etiology KW - Renal Dialysis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79863796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Dialysis+acne.&rft.au=Fuchs%2C+E%3BLynfield%2C+Y&rft.aulast=Fuchs&rft.aufirst=E&rft.date=1990-07-01&rft.volume=23&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The cocaine epidemic: a comprehensive review of use, abuse and dependence. AN - 79863574; 2195399 AB - Surveys from the National Institute on Drug Abuse found that the number of people who had tried cocaine at least once increased from 5.4 million in 1974 to 25 million in 1985. Current use, defined as use in the past 30 days, rose from 1.6 million in 1977 to 6 million in 1985. By 1985, 3 million Americans were dependent on cocaine. The re-emergence of cocaine as an epidemic drug of abuse and dependence is a painful reminder of the cocaine epidemic present in the United States at the turn of the century. This time, however, health care providers are challenged with intricate assessment problems. These are proving problematic in their possible solutions, due to the wide spectrum of consequences, the chronicity of the disease and the necessary lifelong commitment to recovery. This article describes the cocaine epidemic by surveying the effects of its use, abuse and dependence. Because this disorder is multidimensional, the health care provider must examine the physical, psychological, family/social, personal and spiritual domains of health. Viewing cocaine addiction in this way provides an accurate appraisal of cocaine's destructiveness for individuals, the family system and society as a whole. JF - The Nurse practitioner AU - Chychula, N M AU - Okore, C AD - Philadelphia Veterans Administration Medical Center, Addiction Recovery Unit, Pa. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 31 EP - 39 VL - 15 IS - 7 SN - 0361-1817, 0361-1817 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Nursing KW - Humans KW - Disease Outbreaks KW - United States -- epidemiology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79863574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=The+cocaine+epidemic%3A+a+comprehensive+review+of+use%2C+abuse+and+dependence.&rft.au=Chychula%2C+N+M%3BOkore%2C+C&rft.aulast=Chychula&rft.aufirst=N&rft.date=1990-07-01&rft.volume=15&rft.issue=7&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-15 N1 - Date created - 1990-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of fibronectin binding in the rat model of experimental endocarditis caused by Streptococcus sanguis. AN - 79862952; 2164050 AB - Inactivation of fibronectin (Fn) binding by insertional mutagenesis of Streptococcus sanguis with Tn916 reduces virulence of this bacterium in the rat model of infective endocarditis (IE). Transconjugants were screened for Fn adherence using an ELISA adherence test. One transconjugant had a decreased adherence to immobilized Fn. Southern hybridization demonstrated that the insertion occurred only once in this mutant. The parent strain and mutant strain JL113 were used as challenge strains in a rat endocarditis model. These experiments demonstrated that the mutant had a reduced ability (P less than 0.05) to produce IE. Spontaneous excision of Tn916 from JL113 produced strains identical to both the parental and mutant phenotypes. One strain (JLR-19) that retained the mutant phenotype and one (JLR-15) that regained the parental phenotype for Fn binding were tested for their ability to produce IE. These strains demonstrated that the ability to bind Fn and to produce IE were correlated after Tn916 excision. The reduced virulence of the mutant suggested that adherence of S. sanguis to immobilized Fn plays an important role in the production of IE. JF - The Journal of clinical investigation AU - Lowrance, J H AU - Baddour, L M AU - Simpson, W A AD - H.S. Truman Veterans Administration Hospital, University of Missouri, Columbia 65201. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 7 EP - 13 VL - 86 IS - 1 SN - 0021-9738, 0021-9738 KW - DNA Transposable Elements KW - 0 KW - DNA, Bacterial KW - Fibronectins KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Genes, Bacterial KW - Blotting, Southern KW - DNA, Bacterial -- genetics KW - DNA Mutational Analysis KW - Endocarditis, Bacterial -- physiopathology KW - Fibronectins -- physiology KW - Streptococcus sanguis -- pathogenicity KW - Streptococcus sanguis -- genetics KW - Bacterial Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79862952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=The+role+of+fibronectin+binding+in+the+rat+model+of+experimental+endocarditis+caused+by+Streptococcus+sanguis.&rft.au=Lowrance%2C+J+H%3BBaddour%2C+L+M%3BSimpson%2C+W+A&rft.aulast=Lowrance&rft.aufirst=J&rft.date=1990-07-01&rft.volume=86&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Exp Pathol. 1972 Feb;53(1):44-9 [5014243] Rev Infect Dis. 1989 May-Jun;11(3):452-63 [2665003] Acta Pathol Microbiol Scand B. 1975 Apr;83(2):133-40 [1171576] J Mol Biol. 1975 Nov 5;98(3):503-17 [1195397] J Clin Microbiol. 1977 Feb;5(2):184-201 [845245] Int J Cancer. 1977 Jul 15;20(1):1-5 [903179] Infect Immun. 1978 Mar;19(3):915-8 [417032] J Clin Invest. 1978 May;61(5):1394-404 [659601] Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683-7 [291033] Science. 1980 Aug 22;209(4459):927-9 [7403857] Rev Infect Dis. 1979 Nov-Dec;1(6):955-66 [551516] J Infect Dis. 1981 Mar;143(3):325-45 [7014727] Eur J Clin Microbiol. 1982 Dec;1(6):381-7 [6297884] Infect Immun. 1983 Mar;39(3):1457-69 [6188697] J Lab Clin Med. 1984 Jan;103(1):34-43 [6361186] J Bacteriol. 1984 Jul;159(1):214-21 [6330031] J Infect Dis. 1984 Nov;150(5):721-7 [6491379] J Exp Med. 1985 Mar 1;161(3):514-25 [3156205] Am J Med. 1985 Jun 28;78(6B):110-5 [4014276] Am J Pathol. 1985 Jul;120(1):13-21 [4014440] Exp Mol Pathol. 1985 Oct;43(2):151-61 [4043338] Eur J Immunol. 1985 Nov;15(11):1096-101 [2933263] Proc Soc Exp Biol Med. 1985 Dec;180(3):474-82 [3936047] J Cell Sci. 1986 Mar;81:125-41 [3525581] Infect Immun. 1986 Sep;53(3):454-9 [3527982] Annu Rev Microbiol. 1986;40:635-59 [3022640] J Bacteriol. 1987 Mar;169(3):1095-101 [3818541] Infect Immun. 1987 Apr;55(4):923-30 [2881894] Infect Immun. 1988 Sep;56(9):2279-85 [2970435] Rev Infect Dis. 1988 Nov-Dec;10(6):1163-70 [3060944] Infect Immun. 1989 Aug;57(8):2306-12 [2545622] Br J Exp Pathol. 1973 Apr;54(2):142-51 [4700697] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha. AN - 79858543; 2114228 AB - We tested the hypothesis that human recombinant tumor necrosis factor-alpha (TNF) promotes pulmonary edema by neutrophil-dependent effects on the pulmonary vasculature. The isolated guinea pig lung was perfused with phosphate-buffered Ringer's solution with or without human neutrophils. The infusion of neutrophils (9 x 10(6) total) into lungs isolated after the in vivo administration of TNF (3.2 x 10(5) units/kg) resulted in weight gain (+1.951 +/- 0.311 g versus -0.053 +/- 0.053 g in control) and an increase in the lung (wet-dry)-to-dry weight ratio (8.3 +/- 0.5 versus 6.0 +/- 0.2 in control), indicating the formation of pulmonary edema. The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline). The Ppc increase was mediated by thromboxane A2 (TXA2) because the TXA2 synthetase inhibitor Dazoxiben (0.5 mM) prevented the effect (Ppc, 6.7 +/- 0.6 cm H2O at 60 minutes with Dazoxiben), and thromboxane B2 (TXB2) levels were increased in the pulmonary venous effluent (5,244 +/- 599 pg/ml at 60 minutes versus 60 +/- 13 pg/ml at baseline). Studies using WEB-2086 (37 microM), a platelet activating factor (PAF) receptor antagonist, indicated that PAF mediated the increased vascular permeability (Kf,c, 0.107 +/- 0.014 g/min/cm H2O/g at 30 minutes using WEB-2086) and, in part, the increased Ppc (Ppc, 8.4 +/- 0.7 cm H2O at 60 minutes using WEB-2086). In addition, alterations of endothelial peripheral actin bands were noted after TNF administration. The data indicate that TNF induces neutrophil-dependent pulmonary edema associated with increased Ppc (mediated by TXA2 and PAF), increased Kf,c (mediated by PAF), and changes in endothelial peripheral actin bands. JF - Circulation research AU - Hocking, D C AU - Phillips, P G AU - Ferro, T J AU - Johnson, A AD - Research Service, Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 68 EP - 77 VL - 67 IS - 1 SN - 0009-7330, 0009-7330 KW - Actins KW - 0 KW - Arachidonic Acids KW - Tumor Necrosis Factor-alpha KW - Arachidonic Acid KW - 27YG812J1I KW - Index Medicus KW - Animals KW - Endothelium, Vascular -- metabolism KW - Vascular Resistance KW - Guinea Pigs KW - Actins -- metabolism KW - Capillary Permeability KW - Arachidonic Acids -- metabolism KW - Lung -- metabolism KW - Lung -- pathology KW - Organ Size KW - Pulmonary Circulation KW - Biomechanical Phenomena KW - In Vitro Techniques KW - Endothelium, Vascular -- pathology KW - Neutrophils -- physiology KW - Lung -- physiopathology KW - Pulmonary Edema -- metabolism KW - Pulmonary Edema -- chemically induced KW - Pulmonary Edema -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79858543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Mechanisms+of+pulmonary+edema+induced+by+tumor+necrosis+factor-alpha.&rft.au=Hocking%2C+D+C%3BPhillips%2C+P+G%3BFerro%2C+T+J%3BJohnson%2C+A&rft.aulast=Hocking&rft.aufirst=D&rft.date=1990-07-01&rft.volume=67&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cimetidine reduces bile acid-mediated small intestinal mucosal injury in rats in vivo. AN - 79852947; 2364835 AB - Whether cimetidine has protective effects on the gastrointestinal mucosa independent of its ability to reduce gastric acid secretion is still controversial. To study this, rats had small intestinal mucosal injury induced in vivo by perfusion with 5 mM chenodeoxycholic acid. Control rats were compared to rats receiving either intraperitoneal or intravenous pretreatment with 50 mg/kg cimetidine or intraluminal pretreatment with 0.5 mM cimetidine. Mucosal injury was assessed by measuring villus tip epithelial cell denudation by computerized quantitative morphology. Intraperitoneal cimetidine reduced the average denudation/villus (micrometers) caused by 45-min perfusion with chenodeoxycholic acid: control = 39.1 +/- 7.7 (SEM), intraperitoneal cimetidine = 20.8 +/- 3.5 (P less than 0.05). Additionally, both intraluminal and intravenous cimetidine reduced villus denudation caused from 30 min perfusion with chenodeoxycholic acid: control = 62.5 +/- 5.8, intravenous cimetidine = 42.6 +/- 4.7 (P less than 0.05), intraluminal cimetidine = 44.6 +/- 7.2 (P less than 0.05). The observation that reduced mucosal injury is observed in an in vivo model that is independent of gastric acid supports the conclusion that cimetidine indeed has acid-independent protective properties. JF - Digestive diseases and sciences AU - Erickson, R A AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 809 EP - 814 VL - 35 IS - 7 SN - 0163-2116, 0163-2116 KW - Chenodeoxycholic Acid KW - 0GEI24LG0J KW - Cimetidine KW - 80061L1WGD KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Jejunum -- drug effects KW - Perfusion KW - Premedication KW - Time Factors KW - Male KW - Chenodeoxycholic Acid -- toxicity KW - Cimetidine -- therapeutic use KW - Cimetidine -- administration & dosage KW - Intestinal Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79852947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Cimetidine+reduces+bile+acid-mediated+small+intestinal+mucosal+injury+in+rats+in+vivo.&rft.au=Erickson%2C+R+A&rft.aulast=Erickson&rft.aufirst=R&rft.date=1990-07-01&rft.volume=35&rft.issue=7&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of combined substance use on laboratory markers of alcoholism. AN - 79851043; 2359310 AB - This article examines the commonly used laboratory indicators of heavy alcohol use (elevated MCV, GGTP and AST values) in subgroups of drug-using and non-drug-using alcoholic men admitted to an inpatient alcoholism treatment program. A total of 380 consecutive admissions meeting DSM-III diagnostic criteria for alcohol use or dependence were studied. Of these subjects, 75% used both alcohol and drugs. The most frequently used drugs were marijuana, cocaine, amphetamines and tranquilizers. Overall, subjects who used drugs with alcohol had significantly lower MCV and GGTP values than subjects who used alcohol alone. More specifically, cocaine use was associated with lower MCV values, marijuana use with lower AST values and heroin use with higher AST and GGTP values. These differences between drug-using and non-drug-using alcoholics were significant even after controlling for variables that affect the laboratory values such as age, quantity, frequency and duration of alcohol consumption. These findings indicate that any study of laboratory markers of alcoholism needs to consider concomitant illicit drug use patterns. JF - Journal of studies on alcohol AU - Chang, M M AU - Kwon, J AU - Hamada, R S AU - Yahiku, P AD - Honolulu Veterans Administration Outpatient Clinic, Hawaii 96850. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 361 EP - 365 VL - 51 IS - 4 SN - 0096-882X, 0096-882X KW - Amphetamines KW - 0 KW - Barbiturates KW - Biomarkers KW - Hallucinogens KW - Narcotics KW - Heroin KW - 70D95007SX KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Aged KW - Adult KW - Cannabis KW - Middle Aged KW - Male KW - Substance-Related Disorders -- blood KW - Substance-Related Disorders -- complications KW - Biomarkers -- blood KW - Alcoholism -- complications KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79851043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Effect+of+combined+substance+use+on+laboratory+markers+of+alcoholism.&rft.au=Chang%2C+M+M%3BKwon%2C+J%3BHamada%2C+R+S%3BYahiku%2C+P&rft.aulast=Chang&rft.aufirst=M&rft.date=1990-07-01&rft.volume=51&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-02 N1 - Date created - 1990-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Colorectal carcinoma metastases: detection with In-111-labeled monoclonal antibody CCR 086. AN - 79827835; 2353080 AB - A phase I/II clinical trial with indium-111-labeled antimucin murine monoclonal antibody (MoAb) CCR 086 was conducted. Seventeen patients with histologically proved colorectal carcinoma and known metastatic disease underwent external scintigraphy after administration of 5.5 mCi (203.5 MBq) of In-111 CCR 086 at doses of 5 and 20 mg. Of 25 known lesions, 17 were detected (sensitivity, 68%). The smallest detected lesion in the lung was 1 cm and in the liver was 1.5 cm. The serum half-life of In-111-labeled CCR 086 MoAb was approximately 64 hours. The formation of human antimouse antibody (HAMA) was detected in the serum of four of five patients who received 20 mg of MoAb. No HAMAs were detected in four patients receiving 5 mg of MoAb. No side effects were encountered. Because of effective detection of liver and lung metastases with lower doses (5-20 mg) of CCR 086 conjugated with In-111, further investigations are warranted to assess clinical and therapeutic potentials of CCR 086 in the management of colorectal cancer. JF - Radiology AU - Abdel-Nabi, H H AU - Levine, G AU - Lamki, L M AU - Murray, J L AU - Tauxe, W N AU - Shah, A N AU - Patt, Y Z AU - Doerr, R J AU - Klein, H A AU - Gona, J AD - Department of Nuclear Medicine, Veterans Administration Medical Center, Buffalo, NY. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 117 EP - 122 VL - 176 IS - 1 SN - 0033-8419, 0033-8419 KW - Antibodies, Monoclonal KW - 0 KW - Indium Radioisotopes KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Lung Neoplasms -- secondary KW - Humans KW - Liver Neoplasms -- diagnostic imaging KW - Aged KW - Antibody Formation KW - Liver Neoplasms -- secondary KW - Lung Neoplasms -- diagnostic imaging KW - Liver Neoplasms -- diagnosis KW - Radionuclide Imaging KW - Lung Neoplasms -- diagnosis KW - Bone Neoplasms -- diagnostic imaging KW - Adult KW - Middle Aged KW - Mice -- immunology KW - Bone Neoplasms -- diagnosis KW - Male KW - Bone Neoplasms -- secondary KW - Female KW - Neoplasm Metastasis -- diagnostic imaging KW - Indium Radioisotopes -- adverse effects KW - Antibodies, Monoclonal -- pharmacokinetics KW - Indium Radioisotopes -- pharmacokinetics KW - Antibodies, Monoclonal -- adverse effects KW - Neoplasm Metastasis -- diagnosis KW - Colorectal Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79827835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Colorectal+carcinoma+metastases%3A+detection+with+In-111-labeled+monoclonal+antibody+CCR+086.&rft.au=Abdel-Nabi%2C+H+H%3BLevine%2C+G%3BLamki%2C+L+M%3BMurray%2C+J+L%3BTauxe%2C+W+N%3BShah%2C+A+N%3BPatt%2C+Y+Z%3BDoerr%2C+R+J%3BKlein%2C+H+A%3BGona%2C+J&rft.aulast=Abdel-Nabi&rft.aufirst=H&rft.date=1990-07-01&rft.volume=176&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-19 N1 - Date created - 1990-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons. AN - 79795074; 1971609 AB - Laparotomy significantly attenuates ethanol-induced gastric mucosal lesions in the rat. The effects of sensory denervation by capsaicin, indomethacin, atropine, guanethidine, and hexamethonium on laparotomy-induced protection were studied in the rat. Gastric mucosal injury was induced by the intragastric instillation of 1 mL of 75% ethanol. The laparotomy-induced protection against ethanol injury was abolished by sensory denervation by capsaicin (total dose, 125 mg/kg, SC) and also by pretreatment with indomethacin (5 mg/kg, SC). In contrast, pretreatment with atropine (0.5 mg/kg, IP), guanethidine (total dose, 20 mg/kg, SC), or hexamethonium (20 mg/kg, IP) had no significant effect on laparotomy-induced protection. These data indicate that capsaicin-sensitive sensory afferent neurons, but not cholinergic or adrenergic autonomic neurons, mediate laparotomy-induced protection against ethanol injury. The hypothesis is put forward that the protective response to laparotomy arises from a somatovisceral and/or viscerovisceral axon reflex of capsaicin-sensitive afferent neurons. Prostaglandins might play a mediator role in the activation by laparotomy of somatic and/or visceral branches of the afferent neurons. JF - Gastroenterology AU - Yonei, Y AU - Holzer, P AU - Guth, P H AD - Medical Service, Veterans Administration Medical Center West Los Angeles, California. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 3 EP - 9 VL - 99 IS - 1 SN - 0016-5085, 0016-5085 KW - Ganglionic Blockers KW - 0 KW - Hexamethonium Compounds KW - Hexamethonium KW - 3C9PSP36Z2 KW - Ethanol KW - 3K9958V90M KW - Atropine KW - 7C0697DR9I KW - Capsaicin KW - S07O44R1ZM KW - Indomethacin KW - XXE1CET956 KW - Guanethidine KW - ZTI6C33Q2Q KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Ganglionic Blockers -- pharmacology KW - Atropine -- pharmacology KW - Hexamethonium Compounds -- pharmacology KW - Male KW - Indomethacin -- pharmacology KW - Guanethidine -- pharmacology KW - Laparotomy KW - Neurons, Afferent -- drug effects KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Capsaicin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79795074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Laparotomy-induced+gastric+protection+against+ethanol+injury+is+mediated+by+capsaicin-sensitive+sensory+neurons.&rft.au=Yonei%2C+Y%3BHolzer%2C+P%3BGuth%2C+P+H&rft.aulast=Yonei&rft.aufirst=Y&rft.date=1990-07-01&rft.volume=99&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-05 N1 - Date created - 1990-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Evolution of the Self through Optimal Gratification AN - 61591157; 199000091 AB - In an attempt to more accurately grasp how the psychotherapeutic process heals self-pathology, the self-psychological construct of "transmuting internalization" is explored (eg, see Kohut, Heinz, How Does Analysis Cure? Chicago: U of Chicago Press, 1984). This construct has always assumed a climate of attunement, but has emphasized the frustration inherent in the therapeutic process. Here, an alternative way of conceptualizing the process is offered in an attempt to refine theory to better reflect current research, clinical observations, & therapeutic experience; specifically, the primacy of optimal frustration as the curative factor is challenged. Gratification of basic needs through an attuned environment is proposed as the fundamental foundation for the process of self-structuralization. It is argued that first one must be able to express, identify, & interpret affect, & that these abilities are acquired through the activation & gratification of the fundamental needs as delineated by Kohut's concepts of mirroring, idealizing, & twinship. One must have sufficient experiences in feeling valued, confirmed, comforted, affiliated, etc, by a self-object milieu before self-regulating behaviors can develop. 20 References. Modified HA JF - Clinical Social Work Journal AU - Asbury, Helen AD - Cincinnati Veterans Administration Medical Center, 3200 Vine St OH 45220 Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 131 EP - 144 VL - 18 IS - 2 SN - 0091-1674, 0091-1674 KW - self-pathology, psychotherapeutic healing process KW - Self Concept KW - Psychotherapy KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61591157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Social+Work+Journal&rft.atitle=The+Evolution+of+the+Self+through+Optimal+Gratification&rft.au=Asbury%2C+Helen&rft.aulast=Asbury&rft.aufirst=Helen&rft.date=1990-07-01&rft.volume=18&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Clinical+Social+Work+Journal&rft.issn=00911674&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychotherapy; Self Concept ER - TY - JOUR T1 - Health Beliefs in a Population: The Michigan Blood Pressure Survey AN - 61236049; 91X3281 AB - To test the hypothesis that population subgroups with preventable chronic illnesses have less favorable health beliefs, a probability sample of 2,360 adult Mich residents completed a questionnaire survey administered by the U of Michigan, measuring dimensions of the health belief model: general health concern, susceptibility, severity, medical benefits, self-help benefit, & general health threat. Multiple logistic regression assessed the independent association between health belief scale item & sex, race, age, marital status, urbanicity, socioeconomic status, & perceived health level. Markers of social disadvantage, eg, being female, older, &, particularly, black & of low socioeconomic status, appeared to associate with favorable health beliefs, challenging the contention that poor health among the socially disadvantaged is a consequence of health beliefs. Interpretation of the findings for each subgroup & inferences for health programs directed to them are discussed. 4 Tables, 1 Appendix, 26 References. V. Wagener JF - Health Education Quarterly AU - Weissfeld, Joel L AU - Kirscht, John P AU - Brock, Bruce M AD - Ambulatory Care Section Veterans Administration Medical Center, 2215 Fuller Rd Ann Arbor MI 48105 Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 141 EP - 155 VL - 17 IS - 2 SN - 0195-8402, 0195-8402 KW - poor health, socially disadvantaged KW - health beliefs KW - questionnaire survey KW - Michigan KW - Health Care KW - Health Behavior KW - Sociodemographic Factors KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61236049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+Quarterly&rft.atitle=Health+Beliefs+in+a+Population%3A+The+Michigan+Blood+Pressure+Survey&rft.au=Weissfeld%2C+Joel+L%3BKirscht%2C+John+P%3BBrock%2C+Bruce+M&rft.aulast=Weissfeld&rft.aufirst=Joel&rft.date=1990-07-01&rft.volume=17&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Health+Education+Quarterly&rft.issn=01958402&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HEQUDC N1 - SubjectsTermNotLitGenreText - Michigan; Sociodemographic Factors; Health Care; Health Behavior ER - TY - JOUR T1 - Modulation of hippocampal primed burst potentiation by anesthesia. AN - 80021975; 2207654 AB - This study demonstrates that the anesthetics urethane and pentobarbital differentially affect a low threshold form of long-lasting synaptic plasticity, termed primed burst (PB) potentiation, in the CA1 area of rat hippocampus. PB potentiation was generated by the delivery of a 5-pulse patterned stimulus train, consisting of one priming pulse followed 170 ms later by a burst of 4 pulses at 200 Hz. PB potentiation could not be reliably generated in urethane-anesthetized rats unless stimulus currents were raised to 150% of baseline levels during the stimulus train. In pentobarbital-anesthetized rats, PB potentiation could always be evoked at baseline stimulus intensities. Differences between the anesthetics which could contribute to their varying effects upon PB potentiation are discussed. JF - Brain research AU - Engstrom, D A AU - Bennett, M C AU - Stevens, K E AU - Wilson, R L AU - Diamond, D M AU - Fleshner, M AU - Rose, G M AD - Medical Research Service, Veterans Administration Medical Center, Denver, CO 80220. Y1 - 1990/06/25/ PY - 1990 DA - 1990 Jun 25 SP - 148 EP - 152 VL - 521 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Urethane KW - 3IN71E75Z5 KW - Pentobarbital KW - I4744080IR KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Corticosterone -- blood KW - Action Potentials -- drug effects KW - Electric Stimulation KW - Male KW - Anesthesia KW - Hippocampus -- physiology KW - Urethane -- pharmacology KW - Pentobarbital -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80021975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Modulation+of+hippocampal+primed+burst+potentiation+by+anesthesia.&rft.au=Engstrom%2C+D+A%3BBennett%2C+M+C%3BStevens%2C+K+E%3BWilson%2C+R+L%3BDiamond%2C+D+M%3BFleshner%2C+M%3BRose%2C+G+M&rft.aulast=Engstrom&rft.aufirst=D&rft.date=1990-06-25&rft.volume=521&rft.issue=1-2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-09 N1 - Date created - 1990-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regression of nitrosamine-induced pancreatic cancers in hamsters treated with luteinizing hormone-releasing hormone antagonists or agonists. AN - 79780115; 2160323 AB - Groups of 15 female Syrian golden hamsters with N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancers were treated for 2 mo with microcapsules of the luteinizing hormone-releasing hormone (LH-RH) antagonist [Ac-D-Nal(2)1-D-Phe(4Cl)2-D-Pal(3)3,D-Cit6,D-Ala10] LH-RH (SB-75) releasing 8 micrograms/day or with the microcapsules of the LH-RH agonist D-tryptophan-6-luteinizing hormone-releasing hormone (D-Trp-6-LH-RH) releasing 8 micrograms/day or 25 micrograms/day. Chronic treatment with SB-75 resulted in 70% inhibition of pancreatic tumor weight; D-Trp-6-LH-RH in doses of 8 micrograms/day and 25 micrograms/day produced 66% and 62% inhibition, respectively. The number of animals with pancreatic tumors was reduced by about 50% in each treated group. Tumorous ascites were found in seven control hamsters and in one hamster in each group treated with D-Trp-6-LH-RH but not in the group given SB-75. Reduction in serum luteinizing hormone levels and ovarian as well as uterine weights indicated that an inhibition of the pituitary-gonadal axis occurred during chronic SB-75 and D-Trp-6-LH-RH treatment. Membrane receptor assays showed a significant decrease of the concentration of binding sites for LH-RH in tumor cells after SB-75 or D-Trp-6-LH-RH treatment. Insulin-like growth factor I receptors, but not epidermal growth factor receptors, were down-regulated by D-Trp-6-LH-RH. SB-75 did not influence the concentration or the binding capacity of insulin-like growth factor I and epidermal growth factor receptors in the tumor cells. The inhibitory effect of chronic treatment with SB-75 and D-Trp-6-LH-RH on tumor growth was mediated by enhanced apoptosis (programmed cell death) induced by the change in hormonal environment. Apoptosis was also produced in hamsters with N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancers by acute treatment (3 to 6 days) with high doses of D-Trp-6-LH-RH or SB-75. In view of its potency and an immediate powerful inhibitory effect, the LH-RH antagonist SB-75 might be considered as a possible new hormonal agent for the treatment of exocrine pancreatic cancer. JF - Cancer research AU - Szende, B AU - Srkalovic, G AU - Groot, K AU - Lapis, K AU - Schally, A V AD - Endocrine, Polypeptide, and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana 70146. Y1 - 1990/06/15/ PY - 1990 DA - 1990 Jun 15 SP - 3716 EP - 3721 VL - 50 IS - 12 SN - 0008-5472, 0008-5472 KW - Antineoplastic Agents KW - 0 KW - Nitrosamines KW - Receptors, Cell Surface KW - Receptors, LH KW - Receptors, Somatomedin KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Triptorelin Pamoate KW - 57773-63-4 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - cetrorelix KW - OON1HFZ4BA KW - Index Medicus KW - Animals KW - Receptors, LH -- analysis KW - Receptors, Cell Surface -- analysis KW - Mesocricetus KW - Female KW - Remission Induction KW - Cricetinae KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- analysis KW - Pancreatic Neoplasms -- chemically induced KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79780115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Regression+of+nitrosamine-induced+pancreatic+cancers+in+hamsters+treated+with+luteinizing+hormone-releasing+hormone+antagonists+or+agonists.&rft.au=Szende%2C+B%3BSrkalovic%2C+G%3BGroot%2C+K%3BLapis%2C+K%3BSchally%2C+A+V&rft.aulast=Szende&rft.aufirst=B&rft.date=1990-06-15&rft.volume=50&rft.issue=12&rft.spage=3716&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reduced oral contraceptive effectiveness with concurrent antibiotic use: a protocol for prescribing antibiotics to women of childbearing age. AN - 80305834; 2083416 JF - Compendium (Newtown, Pa.) AU - Donley, T G AU - Smith, R F AU - Roy, B AD - RLR Veterans Administration Medical Center, Indianapolis, Indiana. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 392 EP - 396 VL - 11 IS - 6 SN - 0894-1009, 0894-1009 KW - Anti-Bacterial Agents KW - 0 KW - Contraceptives, Oral KW - Penicillins KW - Tetracyclines KW - Dentistry KW - Population KW - United States KW - North America KW - Drug Interactions KW - Americas KW - Physiology KW - Oral Effects KW - Oral Contraceptives KW - Contraceptive Methods KW - Antibiotics KW - Recommendations KW - Treatment KW - Developed Countries KW - Contraception Failure KW - Northern America KW - Contraception KW - Indiana KW - Informed Consent KW - Litigation KW - Literature Review KW - Family Planning KW - Contraceptive Usage KW - Drugs KW - Biology KW - Tetracyclines -- adverse effects KW - Humans KW - Patient Care Planning KW - Penicillins -- adverse effects KW - Female KW - Pregnancy KW - Anti-Bacterial Agents -- adverse effects KW - Pregnancy, Unwanted KW - Contraceptives, Oral -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80305834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Compendium+%28Newtown%2C+Pa.%29&rft.atitle=Reduced+oral+contraceptive+effectiveness+with+concurrent+antibiotic+use%3A+a+protocol+for+prescribing+antibiotics+to+women+of+childbearing+age.&rft.au=Donley%2C+T+G%3BSmith%2C+R+F%3BRoy%2C+B&rft.aulast=Donley&rft.aufirst=T&rft.date=1990-06-01&rft.volume=11&rft.issue=6&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Compendium+%28Newtown%2C+Pa.%29&rft.issn=08941009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-14 N1 - Date created - 1991-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The cardiotoxicity of thiazide diuretics: review of the evidence. AN - 80039119; 2213284 AB - Careful consideration of all relevant scientific evidence and a critical assessment of data quality show that thiazide diuretics are not cardiotoxic. Of 12 reported trials only two recorded more coronary heart disease events in thiazide-treated patients than in controls. One of these two was a subgroup of a larger study (Heart Attack Prevention in Primary Hypertension, HAPPHY) which found no difference between thiazide-treated and beta-blocker-treated patients. The other, the Oslo study, was too small to allow valid conclusions. Results from a subgroup in the Multiple Risk Factor Intervention Trial (MRFIT) that appeared to supply evidence for thiazide-related cardiotoxicity are suspect when examined critically. Further evidence from 24- to 28-h ECG monitoring does not support the hypothesis that thiazide diuretics, either in the presence or absence of hypokalemia, increase the frequency or severity of ventricular arrhythmias. Reports of a thiazide-induced intracellular magnesium deficiency as a cause of ventricular arrhythmias have also not been confirmed; the development of arrhythmias in acute myocardial infarction appears to be due to an increase in catecholamine levels rather than hypokalemia. There appears to be little evidence to support the assumption that long-term use of thiazide diuretics aggravates or accelerates atherosclerosis of the coronary arteries; any fall in serum cholesterol appears to be transient. For the great majority of patients with uncomplicated hypertension, without a previous myocardial infarction, congestive heart failure, diabetes mellitus or gout, thiazide diuretics appear to be both safe and effective antihypertensive agents. JF - Journal of hypertension. Supplement : official journal of the International Society of Hypertension AU - Freis, E D AD - Veterans Administration Medical Center, Washington DC 20422. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - S23 EP - S32 VL - 8 IS - 2 SN - 0952-1178, 0952-1178 KW - Benzothiadiazines KW - 0 KW - Diuretics KW - Sodium Chloride Symporter Inhibitors KW - Cholesterol KW - 97C5T2UQ7J KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Magnesium -- metabolism KW - Cholesterol -- blood KW - Arrhythmias, Cardiac -- chemically induced KW - Myocardial Infarction -- chemically induced KW - Electrocardiography, Ambulatory KW - Death, Sudden -- etiology KW - Humans KW - Sodium Chloride Symporter Inhibitors -- therapeutic use KW - Sodium Chloride Symporter Inhibitors -- adverse effects KW - Coronary Disease -- chemically induced KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80039119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hypertension.+Supplement+%3A+official+journal+of+the+International+Society+of+Hypertension&rft.atitle=The+cardiotoxicity+of+thiazide+diuretics%3A+review+of+the+evidence.&rft.au=Freis%2C+E+D&rft.aulast=Freis&rft.aufirst=E&rft.date=1990-06-01&rft.volume=8&rft.issue=2&rft.spage=S23&rft.isbn=&rft.btitle=&rft.title=Journal+of+hypertension.+Supplement+%3A+official+journal+of+the+International+Society+of+Hypertension&rft.issn=09521178&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-19 N1 - Date created - 1990-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Open trial of cefepime (BMY 28142) for infections in hospitalized patients. AN - 79975421; 2203309 AB - The safety and efficacy of cefepime, a new broad-spectrum, semisynthetic parenteral cephem antibiotic, were evaluated in an open trial at a single hospital. Seventy patients were treated with cefepime: 44 had lower respiratory tract infections, 4 had urinary tract infections, and 22 had skin or soft tissue infections. Of 65 clinically evaluable patients, 64 (98%) had satisfactory responses. No mortality or superinfections occurred. Of 57 respiratory and urinary tract pathogens, 54 (95%) were eradicated and 3 (5%) persisted after therapy. Five bacteremias (two with Streptococcus pneumoniae and one each with Staphylococcus aureus, Proteus mirabilis, and a coagulase-negative staphylococcus) were eradicated. MICs ranged from 1 to 8 micrograms/ml for 13 S. aureus and 9 Pseudomonas aeruginosa isolates and were less than or equal to 0.125 micrograms/ml for 10 streptococcal isolates. Adverse effects occurred in two patients: transient diarrhea and Clostridium difficile toxin in the stool in one patient and loose bowel movements and increased transaminases in the other patient. Cefepime appeared to be well tolerated in humans and was effective against a wide range of isolates, including S. aureus and P. aeruginosa. JF - Antimicrobial agents and chemotherapy AU - Oster, S AU - Edelstein, H AU - Cassano, K AU - McCabe, R AD - Medical Service, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 954 EP - 957 VL - 34 IS - 6 SN - 0066-4804, 0066-4804 KW - Cephalosporins KW - 0 KW - cefepime KW - 807PW4VQE3 KW - Index Medicus KW - Skin -- microbiology KW - Urinary Tract Infections -- drug therapy KW - Skin Diseases, Infectious -- drug therapy KW - Humans KW - Clinical Trials as Topic KW - Follow-Up Studies KW - Urine -- microbiology KW - Respiratory Tract Infections -- drug therapy KW - Microbial Sensitivity Tests KW - Lung -- microbiology KW - Cephalosporins -- adverse effects KW - Hospitalization KW - Infection -- drug therapy KW - Cephalosporins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79975421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Open+trial+of+cefepime+%28BMY+28142%29+for+infections+in+hospitalized+patients.&rft.au=Oster%2C+S%3BEdelstein%2C+H%3BCassano%2C+K%3BMcCabe%2C+R&rft.aulast=Oster&rft.aufirst=S&rft.date=1990-06-01&rft.volume=34&rft.issue=6&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-02 N1 - Date created - 1990-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1984 Oct;26(4):585-90 [6549120] Antimicrob Agents Chemother. 1985 Feb;27(2):207-16 [3885849] Antimicrob Agents Chemother. 1985 Feb;27(2):265-9 [3838637] Antimicrob Agents Chemother. 1989 Apr;33(4):498-502 [2499250] Antimicrob Agents Chemother. 1985 Jul;28(1):51-4 [3899006] Antimicrob Agents Chemother. 1986 May;29(5):845-8 [3524432] Antimicrob Agents Chemother. 1985 Mar;27(3):340-2 [3838872] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk taking and personality. AN - 79966393; 2391639 AB - Comparisons were made of the personality and social orientations of antisocial risk takers, defined as residents in a long-term drug-treatment facility (N = 24); adventurous risk takers, defined as rock climbers (N = 18); and prosocial risk takers, or heroes, defined as policemen and firemen decorated for bravery (N = 21). Measures included substance abuse proclivity, emotional arousability, conformity, moral reasoning, empathy, psychopathy, and sensation seeking. Discriminant analysis identified two functions that correctly classified 98.18% of the sample. Drug-unit residents had high scores on an Antisocial function, characterized by emotionality, depression, psychopathy, substance abuse proclivity, and lower scores on moral reasoning. Rock climbers had high scores on an Antistructural function, characterized by sensation seeking and moral reasoning, the latter reflecting the higher education level of the rock climbers. Neither discriminant function characterized the heroes. Thus, drug-unit residents, rock climbers, and heroes appear to represent both different psychological types and different forms of risk taking. JF - Journal of personality and social psychology AU - Levenson, M R AD - Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 1073 EP - 1080 VL - 58 IS - 6 SN - 0022-3514, 0022-3514 KW - Index Medicus KW - Humans KW - MMPI KW - Adult KW - Substance-Related Disorders -- psychology KW - Socialization KW - Psychometrics KW - Male KW - Risk-Taking KW - Arousal KW - Antisocial Personality Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79966393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Risk+taking+and+personality.&rft.au=Levenson%2C+M+R&rft.aulast=Levenson&rft.aufirst=M&rft.date=1990-06-01&rft.volume=58&rft.issue=6&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-02 N1 - Date created - 1990-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective effects of D-Trp6-luteinising hormone-releasing hormone microcapsules against cyclophosphamide-induced gonadotoxicity in female rats. AN - 79890586; 2142603 AB - The possible protective effect of an agonist of luteinising hormone-releasing hormone (LH-RH) against the ovarian damage caused by cyclophosphamide was investigated in rats. D-Trp6-LH-RH microcapsules were injected once a month for 3 months, in a dose calculated to release 25 micrograms day-1. Control animals received the injection vehicle. Sixty days after the first injection of microcapsules, cyclophosphamide was given at a loading dose of 50 mg kg-1 followed by 5 mg kg-1 day-1 for 30 days, while the treatment with D-Trp6-LH-RH was continued. When the ovaries were examined 3 months and 5 months after discontinuation of treatment, a significant reduction in the total number of follicles (P less than 0.01) was found in non-pretreated animals given cyclophosphamide. This reduction affected mainly follicles larger than 100 microns. An irreversible disintegration and destruction of granulosa cells was also observed in this group. In animals pretreated with D-Trp6-LH-RH, administration of cyclophosphamide caused no reduction in the number and diameter of follicles. Thus, the treatment with D-Trp6-LH-RH microcapsules before and during chemotherapy prevented the ovarian injury inflicted by cyclophosphamide. The suppression of gonadal function by LH-RH analogues could be possibly utilised for the protection of the ovaries against damage caused by cytotoxic drugs. JF - British journal of cancer AU - Bokser, L AU - Szende, B AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 861 EP - 865 VL - 61 IS - 6 SN - 0007-0920, 0007-0920 KW - Capsules KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Triptorelin Pamoate KW - 57773-63-4 KW - Cyclophosphamide KW - 8N3DW7272P KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Luteinizing Hormone -- blood KW - Follicle Stimulating Hormone -- blood KW - Female KW - Organ Size -- drug effects KW - Ovary -- pathology KW - Ovary -- drug effects KW - Cyclophosphamide -- antagonists & inhibitors KW - Cyclophosphamide -- toxicity KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79890586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Protective+effects+of+D-Trp6-luteinising+hormone-releasing+hormone+microcapsules+against+cyclophosphamide-induced+gonadotoxicity+in+female+rats.&rft.au=Bokser%2C+L%3BSzende%2C+B%3BSchally%2C+A+V&rft.aulast=Bokser&rft.aufirst=L&rft.date=1990-06-01&rft.volume=61&rft.issue=6&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=00070920&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-30 N1 - Date created - 1990-08-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biol Reprod. 1978 Oct;19(3):597-605 [363183] Proc Natl Acad Sci U S A. 1988 Apr;85(7):2329-33 [2965391] Cancer. 1980 Apr 15;45(8):2030-7 [6768442] Int J Gynaecol Obstet. 1980;18(5):318-24 [6110575] Blood. 1981 Oct;58(4):849-51 [7272513] J Reprod Fertil. 1982 Nov;66(2):451-6 [7175801] Proc Natl Acad Sci U S A. 1983 Mar;80(5):1459-62 [6219395] Proc Natl Acad Sci U S A. 1985 Mar;82(5):1547-51 [3156381] Crit Rev Oncol Hematol. 1988;8(2):153-71 [3046766] Proc Soc Exp Biol Med. 1968 Jul;128(3):807-11 [5668131] J Reprod Fertil. 1974 Feb;36(2):345-52 [4819316] Clin Biochem. 1974 Sep;7(3):193-201 [4426115] J Reprod Fertil. 1975 Dec;45(3):567-74 [1206657] Science. 1974 Sep 13;185(4155):949-51 [4469672] Cancer. 1978 Jun;41(6):2084-7 [418867] J Reprod Fertil. 1989 Mar;85(2):569-74 [2522987] Int J Pept Protein Res. 1988 Dec;32(6):425-35 [2469662] Acta Endocrinol (Copenh). 1989 Jul;121(1):55-60 [2525857] Arzneimittelforschung. 1990 Feb;40(2 Pt 1):111-8 [2110458] J Endocrinol. 1961 Feb;21:497-509 [13790509] Proc Natl Acad Sci U S A. 1985 May;82(9):2975-9 [3157995] J Urol. 1985 Jul;134(1):187-90 [3925164] Cancer Res. 1985 Aug;45(8):3651-6 [3926307] Cancer Res. 1986 Apr;46(4 Pt 2):1909-14 [3081260] Endocr Rev. 1986 Feb;7(1):115-24 [2420579] Fertil Steril. 1986 Apr;45(4):443-59 [3082680] Cancer Res. 1987 Feb 15;47(4):1093-7 [3542201] Proc Natl Acad Sci U S A. 1987 Feb;84(3):851-5 [2949328] Cancer Res. 1987 Mar 1;47(5):1344-7 [3102044] Cancer Res. 1987 May 1;47(9):2340-3 [3105875] Cancer Res. 1987 Oct 1;47(19):5005-8 [3113726] JAMA. 1988 Apr 8;259(14):2123-5 [3162285] Cancer Res. 1988 Apr 15;48(8):2174-8 [2964898] JAMA. 1979 Oct 26;242(17):1877-81 [480620] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective effect of KCl loading in gentamicin nephrotoxicity. AN - 79865120; 2164323 AB - Aminoglycoside nephrotoxicity in experimental animals can be reduced by calcium loading, inducing diabetes, and giving thyroid hormone, while a potassium deficient diet enhances aminoglycoside nephrotoxicity. This study investigated whether potassium loading protects against gentamicin nephrotoxicity in the rat. In part I, group GK ate a diet containing 3.5% potassium and drank 0.2 mol/L KCl. Pair-fed rats eating a standard diet, group G, ate a 1% potassium diet and drank water. After 10 days, each group received gentamicin subcutaneously, 60 mg/kg twice daily for 8 days. The control groups, K and C, received the high or normal potassium diet, respectively. To control for a protective effect from a high solute load, the effect of equimolar NaCl loading was studied in group GNa and Na. At the end of the 8 days of gentamicin, inulin clearance was significantly higher in GK compared with G(0.6 +/- 0.1 v 0.3 +/- 0.1 mL/min per 100 g body weight [BW], P less than 0.05), but group GNa (0.4 +/- 0.1 mL/min per 100 g BW) was not different from group G. Morphological studies demonstrated that potassium-loaded rats (group GK) had significantly less proximal tubular necrosis compared with rats on a standard potassium diet, group G. Sodium loading did not protect against cellular necrosis. Part II studied renal function, cortical Na,K-adenosine triphosphatase (ATPase) and gentamicin accumulation after 2 days of gentamicin to determine the early functional and biochemical effects of potassium loading before overt renal functional impairment.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Thompson, J R AU - Simonsen, R AU - Spindler, M A AU - Southern, P M AU - Cronin, R E AD - Veterans Administration Medical Center, Dallas, TX 75216. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 583 EP - 591 VL - 15 IS - 6 SN - 0272-6386, 0272-6386 KW - Gentamicins KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Potassium Chloride KW - 660YQ98I10 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Sodium-Potassium-Exchanging ATPase -- analysis KW - Rats, Inbred Strains KW - Rats KW - Kidney Function Tests KW - Animals KW - Necrosis KW - Kidney Tubules, Proximal -- pathology KW - Sodium Chloride -- pharmacology KW - Gentamicins -- toxicity KW - Gentamicins -- antagonists & inhibitors KW - Potassium Chloride -- administration & dosage KW - Potassium Chloride -- pharmacology KW - Kidney -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79865120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Protective+effect+of+KCl+loading+in+gentamicin+nephrotoxicity.&rft.au=Thompson%2C+J+R%3BSimonsen%2C+R%3BSpindler%2C+M+A%3BSouthern%2C+P+M%3BCronin%2C+R+E&rft.aulast=Thompson&rft.aufirst=J&rft.date=1990-06-01&rft.volume=15&rft.issue=6&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-13 N1 - Date created - 1990-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal iron handling in the nephrotic syndrome. AN - 79856730; 2362400 AB - Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak was most severe with a fractional clearance of 25%, a value identical to albumin. In contrast, in puromycin nephrotic syndrome and nephrotoxic serum nephritis the fractional clearance of transferrin was never greater than 2% and consistently less than the fractional clearance of albumin. The fact that iron/transferrin ratios in urine and serum were frequently different, sometimes higher other times lower, documents that iron and transferrin can be dissociated in tubule fluid and handled differently in regards to tubule uptake. Kidney iron concentration is also increased in both immunological and non-immunological forms of nephrotic syndrome. In the proximal tubule iron is present largely on the luminal aspect of the cell. In contrast, the major deposition of iron occurs in the lysosomes of the distal tubule cells. Kidney iron concentration does not correlate with tubule fluid iron content but can be prevented from increasing by systemic iron and/or transferrin depletion. This suggests that iron enters the distal tubule cells with transferrin via its receptors from the basolateral side of the distal tubule cells. In association with the increase tubule fluid and kidney iron, there is a marked reduction in kidney selenium and copper content. It is concluded that urinary iron and transferrin losses can vary greatly in different types of experimental renal diseases, and that iron and transferrin can be dissociated in the tubule fluid.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Kidney international AU - Alfrey, A C AU - Hammond, W S AD - Department of Medicine and Pathology, Veterans' Administration Medical Center, Denver, Colorado. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 1409 EP - 1413 VL - 37 IS - 6 SN - 0085-2538, 0085-2538 KW - Antibodies KW - 0 KW - Autoantibodies KW - Immune Sera KW - Transferrin KW - antiglomerular basement membrane antibody KW - Puromycin Aminonucleoside KW - 58-60-6 KW - Doxorubicin KW - 80168379AG KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Transferrin -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Kidney Glomerulus -- immunology KW - Antibodies -- immunology KW - Animals KW - Puromycin Aminonucleoside -- toxicity KW - Doxorubicin -- toxicity KW - Male KW - Kidney -- metabolism KW - Nephrotic Syndrome -- metabolism KW - Nephrotic Syndrome -- etiology KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79856730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Renal+iron+handling+in+the+nephrotic+syndrome.&rft.au=Alfrey%2C+A+C%3BHammond%2C+W+S&rft.aulast=Alfrey&rft.aufirst=A&rft.date=1990-06-01&rft.volume=37&rft.issue=6&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-06 N1 - Date created - 1990-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - P450IIB gene expression in rat small intestine: cloning of intestinal P450IIB1 mRNA using the polymerase chain reaction and transcriptional regulation of induction. AN - 79845021; 2359402 AB - Intestinal cytochromes P450 (P450) may function in the "first pass" metabolism of drugs, the detoxification of xenobiotics, or the activation of carcinogens. However, little is known about the expression of specific P450 genes in intestinal mucosa. We have previously shown that a P450 mRNA that is homologous to rat liver P450IIB1 (P450b) is expressed in rat small intestine and is inducible by phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides. However, there are multiple highly homologous genes in the IIB subfamily and, therefore, studies using liver-derived cDNAs or oligonucleotides based on those cDNAs cannot definitively establish the identity of the intestinal mRNA(s). The polymerase chain reaction was used to enzymatically amplify cDNA synthesized from intestinal and hepatic RNA, and the amplified segments were identified by Southern blot analysis. These studies demonstrated that the amplified segment of the phenobarbital-inducible P450 mRNA in intestine was identical to this same segment of the hepatic P450b mRNA; furthermore, this analysis showed that P450e was not expressed in intestine. To definitively establish the identity of the intestinal mRNA, the full coding sequence of the P450b mRNA was cloned from intestinal and hepatic RNA and sequenced. The sequences of the intestinal and hepatic cDNA were identical and coded for P450b; the deduced protein sequence in the F344 rat differed in one amino acid from the reported sequence in Sprague-Dawley rats and, thus, represents a different allele of the same gene. An increment in intestinal P450b mRNA was detected as early as 1 hr following a single intraperitoneal injection of phenobarbital; this prompt rise in mRNA suggested that transcriptional activation may be the primary mechanism for induction. Nuclear run-on experiments were performed using nuclei isolated from intestinal mucosa 3 and 6 hr following treatment with phenobarbital. The rate of transcription of the P450IIB1 gene was increased approximately 6-fold 6 hr following phenobarbital; this was very similar to the increment in P450b mRNA as measured by quantitative dot blot analysis. Therefore, the predominant mechanism for the induction of P450b mRNA in intestine in response to phenobarbital was an increase in gene transcription. These studies indicate that the same member of the P450IIB subfamily, P450IIB1 or P450b, is expressed and inducible by similar mechanisms in small intestine and liver. Although putative P450b mRNA and apoprotein have been identified in lung and testes, the capacity for induction by phenobarbital, and presumably other xenobiotics, is unique to liver and intestine.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Molecular pharmacology AU - Traber, P G AU - Wang, W AU - McDonnell, M AU - Gumucio, J J AD - Department of Internal Medicine, Ann Arbor Veterans Administration Medical Center, Michigan. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 810 EP - 819 VL - 37 IS - 6 SN - 0026-895X, 0026-895X KW - RNA, Messenger KW - 0 KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Cell Nucleus -- metabolism KW - Transcription, Genetic KW - Amino Acid Sequence KW - DNA -- biosynthesis KW - Cloning, Molecular KW - Rats, Inbred Strains KW - Rats KW - Polymerase Chain Reaction KW - Base Sequence KW - Rats, Inbred F344 KW - Kinetics KW - Molecular Sequence Data KW - Male KW - Cytochrome P-450 Enzyme System -- genetics KW - Intestine, Small -- metabolism KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Gene Expression Regulation KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79845021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=P450IIB+gene+expression+in+rat+small+intestine%3A+cloning+of+intestinal+P450IIB1+mRNA+using+the+polymerase+chain+reaction+and+transcriptional+regulation+of+induction.&rft.au=Traber%2C+P+G%3BWang%2C+W%3BMcDonnell%2C+M%3BGumucio%2C+J+J&rft.aulast=Traber&rft.aufirst=P&rft.date=1990-06-01&rft.volume=37&rft.issue=6&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-01 N1 - Date created - 1990-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 31P NMR studies of ATP concentrations and Pi-ATP exchange in the rat kidney in vivo: effects of inhibiting and stimulating renal metabolism. AN - 79837407; 2355828 AB - Previous investigators found that cyanide (CN-) is a potent inhibitor of renal Na+ transport, while the uncoupling agent 2,4-dinitrophenol (DNP) and fructose (both which lower ATP levels) are weak transport inhibitors. To examine the disparate effects of these substances measurements of ATP were performed, using 31P NMR, while simultaneously monitoring renal Na+ transport. Infusion of CN-, DNP, and fructose lowered whole kidney ATP levels by about the same extent (30%) while only CN- inhibited Na+ transport. This may be due to the fact that CN- has a potent action on the thick ascending limb of Henle, while fructose and DNP may have a more proximal action. Alternatively, ATP turnover may be a more important determinant of transport than ATP concentrations. Saturation transfer experiments were performed to measure Pi-ATP flux. Unilateral nephrectomy, high protein feeding, and methylprednisolone were used to stimulate metabolism and transport. The rate of Pi-ATP flux was 20.1 mumol/min/g. However, because oxygen consumption was stimulated, the ATP/O ratio was 0.85, considerably less than the theoretical value of 3. Finally, atrial natriuretic factor, which increased Na+ transport, had no effect on Pi-ATP flux. The results raise the possibility that the saturation transfer technique does not detect all Pi-ATP flux, especially when renal metabolism is stimulated. JF - Magnetic resonance in medicine AU - Shine, N AU - Xuan, A AU - Weiner, M W AD - Magnetic Resonance Unit, Veterans Administration Medical Center, University of California, San Francisco 94121. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 445 EP - 460 VL - 14 IS - 3 SN - 0740-3194, 0740-3194 KW - Dinitrophenols KW - 0 KW - Phosphates KW - Fructose KW - 30237-26-4 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Sodium KW - 9NEZ333N27 KW - Sodium Cyanide KW - O5DDB9Z95G KW - 2,4-Dinitrophenol KW - Q13SKS21MN KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Sodium Cyanide -- pharmacology KW - Animals KW - Oxygen Consumption KW - Dinitrophenols -- pharmacology KW - Sodium -- metabolism KW - Fructose -- pharmacology KW - Phosphates -- metabolism KW - Kidney -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Kidney -- drug effects KW - Magnetic Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79837407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+resonance+in+medicine&rft.atitle=31P+NMR+studies+of+ATP+concentrations+and+Pi-ATP+exchange+in+the+rat+kidney+in+vivo%3A+effects+of+inhibiting+and+stimulating+renal+metabolism.&rft.au=Shine%2C+N%3BXuan%2C+A%3BWeiner%2C+M+W&rft.aulast=Shine&rft.aufirst=N&rft.date=1990-06-01&rft.volume=14&rft.issue=3&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Magnetic+resonance+in+medicine&rft.issn=07403194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-25 N1 - Date created - 1990-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic focal epilepsy induced by microinjection of tetanus toxin into the cat motor cortex. AN - 79831545; 1693899 AB - The tetanus toxin model of epilepsy, involving direct microinjection of toxin into the mammalian brain, has a number of advantages relative to other chronic models. However, chronic seizure foci have been confined primarily to the hippocampus. In the present study, 5 cats received total doses of 7.5-22.5 ng of tetanus toxin applied to the left primary motor cortex through an epidural cannula. After 2-18 days, all 5 cats exhibited similar persistent epileptiform syndromes. Three distinct types of spontaneous seizures were noted: focal motor seizures of variable complexity, focal motor seizures with secondary generalization, and epilepsia partialis continua. All cats required anticonvulsant therapy. Simple focal motor seizures, which predominated, were electrographically characterized by 3-5 Hz spike-sharp wave activity, originating in the left motor cortex, associated with contralateral shoulder and forepaw clonus and jacksonian spread. Electrographic activity quickly spread to ipsilateral neocortical structures, and in longer episodes to the cingulate gyri. Seizure foci were still active as long as 37 days after toxin injection. Light microscopic damage attributable to the toxin was absent. These experiments further generalized the tetanus toxin model and confirmed its advantages. JF - Electroencephalography and clinical neurophysiology AU - Louis, E D AU - Williamson, P D AU - Darcey, T M AD - Neurology Service, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 548 EP - 557 VL - 75 IS - 6 SN - 0013-4694, 0013-4694 KW - Tetanus Toxin KW - 0 KW - Index Medicus KW - Animals KW - Electrodes, Implanted KW - Electroencephalography KW - Cats KW - Disease Models, Animal KW - Chronic Disease KW - Microinjections KW - Female KW - Tetanus Toxin -- administration & dosage KW - Motor Cortex -- pathology KW - Motor Cortex -- physiopathology KW - Epilepsies, Partial -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79831545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electroencephalography+and+clinical+neurophysiology&rft.atitle=Chronic+focal+epilepsy+induced+by+microinjection+of+tetanus+toxin+into+the+cat+motor+cortex.&rft.au=Louis%2C+E+D%3BWilliamson%2C+P+D%3BDarcey%2C+T+M&rft.aulast=Louis&rft.aufirst=E&rft.date=1990-06-01&rft.volume=75&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Electroencephalography+and+clinical+neurophysiology&rft.issn=00134694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-26 N1 - Date created - 1990-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spinal cord toxicity complicating treatment with cisplatin and etoposide. AN - 79796815; 2161175 AB - Neurologic toxicity occurring in patients treated with cisplatin chemotherapy is limited primarily to peripheral neuropathy and ototoxicity. Lhermitte's sign, electric-like paresthesias precipitated by cervical spine flexion, has recently been described as a self-limited complication in cisplatin-treated patients. We report the development of Lhermitte's sign accompanied by cervical motor neuropathy, dorsal column myelopathy, and sensory neuropathy in a patient treated with cisplatin and etoposide for small cell lung cancer. Persistence of the neurologic deficit suggests that potentially irreversible spinal cord toxicity may complicate treatment with this chemotherapy combination. JF - American journal of clinical oncology AU - List, A F AU - Kummet, T D AD - Department of Medicine, Veterans Administration Medical Center, Phoenix, Arizona. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 256 EP - 258 VL - 13 IS - 3 SN - 0277-3732, 0277-3732 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Spinal Cord Diseases -- chemically induced KW - Spinal Cord -- drug effects KW - Lung Neoplasms -- drug therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Carcinoma, Small Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79796815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=Spinal+cord+toxicity+complicating+treatment+with+cisplatin+and+etoposide.&rft.au=List%2C+A+F%3BKummet%2C+T+D&rft.aulast=List&rft.aufirst=A&rft.date=1990-06-01&rft.volume=13&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-29 N1 - Date created - 1990-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A survey of state regulation of testing for drugs of abuse outside of licensed (accredited) clinical laboratories. AN - 79789235; 2343957 AB - We surveyed all 50 states to find out if testing for drugs of abuse outside of clinical laboratories was regulated. In 14 states such regulations existed or were contemplated. Eight additional states indicated that regulatory language does not restrict their oversight of such testing. Content of the regulations is described for each of these 22 states. JF - American journal of public health AU - Baer, D M AU - Belsey, R E AU - Skeels, M R AD - Laboratory Service, Veterans Administration Medical Center, Portland, OR 97207. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 713 EP - 715 VL - 80 IS - 6 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Substance-Related Disorders -- diagnosis KW - Quality Assurance, Health Care -- legislation & jurisprudence KW - Laboratories -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79789235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=A+survey+of+state+regulation+of+testing+for+drugs+of+abuse+outside+of+licensed+%28accredited%29+clinical+laboratories.&rft.au=Baer%2C+D+M%3BBelsey%2C+R+E%3BSkeels%2C+M+R&rft.aulast=Baer&rft.aufirst=D&rft.date=1990-06-01&rft.volume=80&rft.issue=6&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1986 Jan 17;255(3):374-82 [3941518] JAMA. 1986 Feb 14;255(6):775-86 [3511313] Clin Lab Med. 1986 Jun;6(2):345-54 [3522077] JAMA. 1988 Sep 23-30;260(12):1749-54 [3411757] JAMA. 1987 Jul 17;258(3):357-61 [3599330] JAMA. 1987 Sep 25;258(12):1634-8 [3625971] Am J Public Health. 1988 Jul;78(7):817-9 [3381957] JAMA. 1987 Jul 17;258(3):353-6 [3599329] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Uncoupling of sodium chloride transport in premalignant mouse colon. AN - 79765512; 1692547 AB - Ion transport across premalignant large bowel mucosa in CF1 mice was evaluated by measuring sodium and chloride fluxes across voltage-clamped colonic segments obtained from control animals and animals treated for 4 wk with the procarcinogen 1,2-dimethylhydrazine, which induces tumor development principally in the distal colon. In control CF1 mouse colon, the net flux of sodium was 5.1 +/- 0.7 and 4.6 +/- 0.7 microEq.cm-2.h-1 and the net flux of chloride was 6.1 +/- 1.3 and 0.8 +/- 1.2 microEq.cm-2.h-1 in the distal and proximal colon, respectively. Removal of bicarbonate decreased the net flux of sodium 1.5 +/- 0.5 and 1.9 +/- 0.7 microEq.cm-2.h-1 in the distal and proximal colon, respectively, while the net flux of chloride was decreased to 1.7 +/- 1.8 microEq.cm-2.h-1 in the distal colon but was unaltered (0.8 +/- 0.1 microEq.cm-2.h-1) in the proximal colon. Addition of 25 mM bicarbonate stimulated the net flux of sodium and chloride absorption in the distal colon but increased net flux of sodium absorption alone in the proximal colon and stimulated net flux of chloride secretion. Removal of chloride decreased net flux of sodium to 3.4 +/- 1.4 and 1.8 +/- 0.8 microEq.cm-2.h-1 in the distal and proximal colon, respectively. Addition of 20 mM Cl stimulated net flux of sodium in the distal but not the proximal colon. These data suggest that sodium absorption is mediated by an electroneutral Cl-dependent, HCO3-dependent process (i.e., Na-H Cl-HCO3 dual exchange) in control distal colon and by an electroneutral HCO3-dependent process in control proximal colon. Following 1,2-dimethylhydrazine treatment, net flux of sodium in the distal colon was not stimulated by the addition of Cl or HCO3, and transport in the proximal colon was similar to that in control animals. However, 1,2-dimethylhydrazine treatment appears to uncouple Na-H Cl-HCO3 exchange in the distal colon early in the process of large bowel carcinogenesis. JF - Gastroenterology AU - Davies, R J AU - Asbun, H AU - Thompson, S M AU - Goller, D A AU - Sandle, G I AD - Department of Surgery, Veterans Administration Medical Center, San Diego, California. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 1502 EP - 1508 VL - 98 IS - 6 SN - 0016-5085, 0016-5085 KW - Bicarbonates KW - 0 KW - Carcinogens KW - Chlorides KW - Dimethylhydrazines KW - Ion Channels KW - Isotonic Solutions KW - Sodium Channels KW - Ringer's solution KW - 8026-10-6 KW - 1,2-Dimethylhydrazine KW - IX068S9745 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Electric Conductivity KW - Dimethylhydrazines -- adverse effects KW - Intestinal Mucosa -- metabolism KW - Action Potentials -- drug effects KW - Mice KW - Rats, Inbred Strains KW - Rats KW - Bicarbonates -- pharmacology KW - Female KW - Ion Channels -- drug effects KW - Sodium Channels -- metabolism KW - Colonic Neoplasms -- metabolism KW - Chlorides -- metabolism KW - Precancerous Conditions -- metabolism KW - Sodium Channels -- drug effects KW - Ion Channels -- metabolism KW - Chlorides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79765512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Uncoupling+of+sodium+chloride+transport+in+premalignant+mouse+colon.&rft.au=Davies%2C+R+J%3BAsbun%2C+H%3BThompson%2C+S+M%3BGoller%2C+D+A%3BSandle%2C+G+I&rft.aulast=Davies&rft.aufirst=R&rft.date=1990-06-01&rft.volume=98&rft.issue=6&rft.spage=1502&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-18 N1 - Date created - 1990-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Internal vs. External Determinants of Coping Responses to Stressful Life-Events in the Elderly AN - 61256923; 92Y4592 AB - The effect of type of stressful life event, appraisal of degree of threat, & demographic variables on coping behavior & the coping consistency of individuals across situations was examined in a longitudinal study of 74 elderly living independently. Correlational analyses indicated that coping responses were more a function of event type than of an individual's consistent style. A number of distinct life-events were associated with particular types of coping responses, including wishful thinking, advice seeking, self-blame, & seeking social support. Uncertainty about an event was related to higher problem-solving, problem-focused, emotion-focused, & total coping scores. Age was negatively correlated with problem-focused coping & total number of coping responses. 3 Tables, 24 References. Adapted from the source document. JF - The British Journal of Medical Psychology AU - Patterson, Thomas L AU - Smith, Lawrence W AU - Grant, Igor AU - Clopton, Paul AU - Josepho, Sharon AU - Yager, Joel AD - Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 149 EP - 160 VL - 63 IS - 2 SN - 0007-1129, 0007-1129 KW - coping behavior/consistency, independent-living elderly KW - life event stressor type/threat assessment/demographic variables KW - longitudinal data KW - Psychological Stress KW - Elderly KW - Life Events KW - Coping KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61256923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Medical+Psychology&rft.atitle=Internal+vs.+External+Determinants+of+Coping+Responses+to+Stressful+Life-Events+in+the+Elderly&rft.au=Patterson%2C+Thomas+L%3BSmith%2C+Lawrence+W%3BGrant%2C+Igor%3BClopton%2C+Paul%3BJosepho%2C+Sharon%3BYager%2C+Joel&rft.aulast=Patterson&rft.aufirst=Thomas&rft.date=1990-06-01&rft.volume=63&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Medical+Psychology&rft.issn=00071129&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - BJMPAB N1 - SubjectsTermNotLitGenreText - Elderly; Psychological Stress; Coping; Life Events ER - TY - JOUR T1 - Lithium toxicity: when is hemodialysis necessary? AN - 1171891420; 17356483 AB - A case of severe lithium intoxication is presented in which the function of the lithium pump was monitored, and ws found to improve as teh signs of lithium toxicity abated. The status of the lithium pump may provide an index of the severity of lithium intoxication. Since the lithium pump regulates the extrusion of lithium from the intracellular to the extracellular space, it is argued that the activity of the lithium pump is an index of the severity of lithium intoxication and crucial to the process of detoxification. JF - Acta Psychiatrica Scandinavica AU - Hauger, R L AU - O'Connor, KA AU - Yudofsky, S AU - Meltzer, H L AD - San Diego Veterans Administration Medical Center and Department of Psychiatry, University of California San Diego, La Jolla, California Y1 - 1990/06// PY - 1990 DA - Jun 1990 SP - 515 EP - 517 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 81 IS - 6 SN - 0001-690X, 0001-690X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Detoxification KW - Lithium KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171891420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Psychiatrica+Scandinavica&rft.atitle=Lithium+toxicity%3A+when+is+hemodialysis+necessary%3F&rft.au=Hauger%2C+R+L%3BO%27Connor%2C+KA%3BYudofsky%2C+S%3BMeltzer%2C+H+L&rft.aulast=Hauger&rft.aufirst=R&rft.date=1990-06-01&rft.volume=81&rft.issue=6&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Acta+Psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/10.1111%2Fj.1600-0447.1990.tb05490.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Lithium DO - http://dx.doi.org/10.1111/j.1600-0447.1990.tb05490.x ER - TY - JOUR T1 - Inhibitory effects of analogs of luteinizing hormone-releasing hormone and somatostatin on pancreatic cancers in hamsters. Events that accompany tumor regression. AN - 79800410; 1971771 AB - Syrian golden hamsters bearing N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinomas were treated for 2 months with the delayed delivery systems of the agonist D-Trp-6-LH-RH (microcapsules releasing 25 micrograms/day for 30 days), the somatostatin analog RC-160 (the microcapsules liberating 48.2 micrograms/day for 30 days), or with the combination of these two analogues. The increase in the dose of RC-160 was possible in view of the lack of toxicity of this analog. This higher dose of RC-160 exerted a greater suppressive effect on pancreatic cancers than the regimens previously used (5-25 micrograms/day). RC-160, D-Trp-6-LH-RH, and their combination reduced the number of pancreatic carcinomas and significantly inhibited tumor growth as compared with the controls. The combination had the strongest tumor-inhibitory effect and reduced tumor weight by 85% as compared with controls. Both the light and electron microscopic analysis of the tumors showed that the inhibitory effect was due to the enhancement of apoptosis (programmed cell death) of tumor cells. Insulin-like growth factor (IGF-I) receptors were detected immunohistochemically in the untreated tumors and their number decreased after the treatment with the analogues. Binding of D-Trp-6-LH-RH and RC-160 to tumor cells was shown immunohistochemically and receptors to these analogues and IGF-I were also determined biochemically by radioligand titration. Treatment with D-Trp-6-LH-RH and RC-160 decreased the binding capacity of receptors for D-Trp-6-LH-RH and IGF-I, producing down-regulation of these receptors. This suggests that pancreatic tumor cells with receptors to these peptides are sensitive to the treatment. This work reinforces the view that the combination of high doses of somatostatin analog RC-160 with LH-RH agonists or antagonists should be considered for the development of a new hormonal therapy for ductal pancreatic cancers. JF - Cancer AU - Szende, B AU - Srkalovic, G AU - Schally, A V AU - Lapis, K AU - Groot, K AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1990/05/15/ PY - 1990 DA - 1990 May 15 SP - 2279 EP - 2290 VL - 65 IS - 10 SN - 0008-543X, 0008-543X KW - Delayed-Action Preparations KW - 0 KW - Receptors, Cell Surface KW - Receptors, Somatomedin KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Luteinizing Hormone KW - 9002-67-9 KW - Growth Hormone KW - 9002-72-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cytoplasm -- ultrastructure KW - Growth Hormone -- blood KW - Receptors, Cell Surface -- analysis KW - Insulin-Like Growth Factor I -- metabolism KW - Amino Acid Sequence KW - Necrosis KW - Molecular Sequence Data KW - Mesocricetus KW - Luteinizing Hormone -- blood KW - Macrophages -- ultrastructure KW - Female KW - Cricetinae KW - Gonadotropin-Releasing Hormone -- analysis KW - Pancreatic Neoplasms -- pathology KW - Somatostatin -- analysis KW - Pancreatic Neoplasms -- blood KW - Somatostatin -- analogs & derivatives KW - Somatostatin -- administration & dosage KW - Pancreatic Neoplasms -- drug therapy KW - Gonadotropin-Releasing Hormone -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79800410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Inhibitory+effects+of+analogs+of+luteinizing+hormone-releasing+hormone+and+somatostatin+on+pancreatic+cancers+in+hamsters.+Events+that+accompany+tumor+regression.&rft.au=Szende%2C+B%3BSrkalovic%2C+G%3BSchally%2C+A+V%3BLapis%2C+K%3BGroot%2C+K&rft.aulast=Szende&rft.aufirst=B&rft.date=1990-05-15&rft.volume=65&rft.issue=10&rft.spage=2279&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-12 N1 - Date created - 1990-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells. AN - 79756859; 2334893 AB - Exposure of HL-60 promyelocytes to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate increased incorporation of 32P into a Mr approximately 33,000 protein (NP33) found in the nuclear matrices prepared by treating cells with Triton X-100, nucleases, and 2 M NaCl (D. E. Macfarlane, J. Biol. Chem., 261: 6947-6953, 1986). We now report that 12-O-tetradecanoylphorbol-13-acetate causes phosphorylation of NP33 in U937, K562, HEL, Molt-3, and Raji cell lines, all of which are rapidly proliferating cells of hematopoietic origin. 12-O-Tetradecanoylphorbol-13-acetate caused a lesser degree of NP33 phosphorylation in peripheral blood lymphocytes and monocytes and none in granulocytes or platelets. The incorporation of 32P into NP33 was complete in about 10 min, and it was prevented or reversed by staurosporin, indicating that NP33 is continuously phosphorylated and dephosphorylated. NP33 was purified to homogeneity from Triton X-100-washed nuclei or whole cells by extraction with H2SO4, acetone precipitation, and preparative two-dimensional gel electrophoresis. The amino-terminal amino acid sequence of NP33 appears to be the same as that of ribosomal S6 protein. NP33 appears to be S6 protein copurifying with the nuclear matrix. JF - Cancer research AU - Macfarlane, D E AU - Gailani, D AD - Department of Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1990/05/15/ PY - 1990 DA - 1990 May 15 SP - 2895 EP - 2900 VL - 50 IS - 10 SN - 0008-5472, 0008-5472 KW - Alkaloids KW - 0 KW - Nuclear Proteins KW - Phosphoproteins KW - Protein Kinase Inhibitors KW - Ribosomal Protein S6 KW - Ribosomal Proteins KW - Staurosporine KW - H88EPA0A3N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphorylation KW - Humans KW - Electrophoresis, Gel, Two-Dimensional KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Alkaloids -- pharmacology KW - Amino Acid Sequence KW - Cell Line KW - Nuclear Proteins -- analysis KW - Ribosomal Proteins -- metabolism KW - Phosphoproteins -- analysis KW - Ribosomal Proteins -- analysis KW - Nuclear Proteins -- metabolism KW - Hematopoietic Stem Cells -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79756859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Identification+of+phosphoprotein+NP33+as+a+nucleus-associated+ribosomal+S6+protein+and+its+phosphorylation+in+hematopoietic+cells.&rft.au=Macfarlane%2C+D+E%3BGailani%2C+D&rft.aulast=Macfarlane&rft.aufirst=D&rft.date=1990-05-15&rft.volume=50&rft.issue=10&rft.spage=2895&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-12 N1 - Date created - 1990-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Production of anticardiolipin antibodies by cultured human lymphocytes. AN - 80414889; 1967031 AB - Antibodies against negatively charged phospholipids, such as those to cardiolipin, can often be detected in the serum of patients with autoimmune related conditions, chronic infections and in patients treated with phenothiazines. In the present study, peripheral blood lymphocytes from nine healthy controls and eight patients with phenothiazine-induced IgM anticardiolipin antibodies (ACA) and the lupus anticoagulant were placed in vitro. Culture supernatants were assayed for ACA by measurement of optical densities using an ELISA. A significant difference (p less than 0.05) was demonstrated between the mean concentration of culture supernatant ACA from the patients as compared to healthy controls. The concentration of ACA in culture supernatants strongly correlated (r = 0.85) with that from the serum. There was a weak correlation between serum and culture supernatant ACA concentration and the lupus anticoagulant activity as measured by prolongation of the partial thromboplastin time. This technique uses readily accessible peripheral blood lymphocytes and should permit dissection of cytokine and cellular immune pathways regulating APA production. JF - Journal of clinical & laboratory immunology AU - Smith, H R AU - Hansen, C L AU - Canoso, R T AD - Rheumatology Section, Boston Veterans Administration Medical Center. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 1 EP - 4 VL - 32 IS - 1 SN - 0141-2760, 0141-2760 KW - Autoantibodies KW - 0 KW - Cardiolipins KW - Immunoglobulin M KW - Lupus Coagulation Inhibitor KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Immunoglobulin M -- blood KW - Antiphospholipid Syndrome -- immunology KW - Lupus Coagulation Inhibitor -- biosynthesis KW - Cells, Cultured KW - Humans KW - Antiphospholipid Syndrome -- blood KW - Lupus Coagulation Inhibitor -- analysis KW - Antiphospholipid Syndrome -- chemically induced KW - Male KW - Partial Thromboplastin Time KW - Cardiolipins -- immunology KW - Autoantibodies -- immunology KW - Autoantibodies -- analysis KW - B-Lymphocytes -- immunology KW - Autoantibodies -- biosynthesis KW - Chlorpromazine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80414889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+%26+laboratory+immunology&rft.atitle=Production+of+anticardiolipin+antibodies+by+cultured+human+lymphocytes.&rft.au=Smith%2C+H+R%3BHansen%2C+C+L%3BCanoso%2C+R+T&rft.aulast=Smith&rft.aufirst=H&rft.date=1990-05-01&rft.volume=32&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+%26+laboratory+immunology&rft.issn=01412760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Is ethanol per se hepatotoxic? AN - 79858419; 2195111 JF - Journal of hepatology AU - Derr, R F AU - Porta, E A AU - Larkin, E C AU - Rao, G A AD - Research Service (151B), Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 381 EP - 386 VL - 10 IS - 3 SN - 0168-8278, 0168-8278 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Papio KW - Animals KW - Humans KW - Male KW - Female KW - Liver -- drug effects KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79858419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Is+ethanol+per+se+hepatotoxic%3F&rft.au=Derr%2C+R+F%3BPorta%2C+E+A%3BLarkin%2C+E+C%3BRao%2C+G+A&rft.aulast=Derr&rft.aufirst=R&rft.date=1990-05-01&rft.volume=10&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-14 N1 - Date created - 1990-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of joint motion on experimental calcium pyrophosphate dihydrate crystal induced arthritis. AN - 79848299; 2162961 AB - We studied the effects of joint movement and immobilization on acute and chronic calcium pyrophosphate dihydrate (CPPD) crystal induced arthritis in lapine knee joints. Exercised CPPD injected joints, in both acute (single 10 mg CPPD intraarticular (IA), duration: 5 h) and chronic (repeated 10 mg CPPD IA, duration: 20 and 42 days) experiments, demonstrated a more intense histologic synovitis compared to cast immobilized knees (p = 0.0001). In chronic experiments, both CPPD injected and noninjected immobilized knees showed greater cartilage histopathologic-histochemical abnormalities (p less than 0.004) and significant reduction in cartilage hexosamine content (p less than 0.005), compared to exercised joints. CPPD injected knees, both exercised and immobilized, demonstrated an initial phase of increased cartilage biosynthetic activity (35S incorporation) at 20 days, compared to noninjected knees (p = 0.02), followed by a decline at 42 days (p less than 0.005). Our data indicate that joint movement enhances acute and chronic experimental CPPD crystal induced synovitis. Articular cartilage is more adversely affected by joint immobilization than by chronic crystalline inflammation. An optimum balance between exercise and rest seems necessary for patients with arthritis so that cartilage can be preserved but pain from active inflammation also controlled. JF - The Journal of rheumatology AU - Fam, A G AU - Schumacher, H R AU - Clayburne, G AU - Villanueva, T AU - Baker, D AU - Jimenez, S A AD - Department of Medicine, Veterans Administration Medical Center, Toronto, ON, Canada. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 644 EP - 655 VL - 17 IS - 5 SN - 0315-162X, 0315-162X KW - Diphosphates KW - 0 KW - Calcium Pyrophosphate KW - X69NU20D19 KW - Index Medicus KW - Space life sciences KW - Crystallization KW - Cartilage, Articular -- metabolism KW - Animals KW - Rabbits KW - Histocytochemistry KW - Cartilage, Articular -- pathology KW - Time Factors KW - Synovial Fluid -- metabolism KW - Male KW - Immobilization KW - Synovial Membrane -- pathology KW - Joints -- physiopathology KW - Arthritis -- chemically induced KW - Arthritis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79848299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Effect+of+joint+motion+on+experimental+calcium+pyrophosphate+dihydrate+crystal+induced+arthritis.&rft.au=Fam%2C+A+G%3BSchumacher%2C+H+R%3BClayburne%2C+G%3BVillanueva%2C+T%3BBaker%2C+D%3BJimenez%2C+S+A&rft.aulast=Fam&rft.aufirst=A&rft.date=1990-05-01&rft.volume=17&rft.issue=5&rft.spage=644&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-27 N1 - Date created - 1990-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Rheumatol. 1991 Jan;18(1):151 [2023191] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tyrosine kinase activation during lung injury, fibrosis, and compensatory lung growth. AN - 79847865; 2357948 AB - Endobronchial instillation of paraquat into left lungs of rats resulted in ipsilateral fibrosis (evaluated by light and electron microscopy) and compensatory growth of the contralateral lung. Tyrosine kinase (Tyr-K) activity rose early in the fibrotic lung, peaked to a value 4 times the controls on day 3, and remained elevated on day 14. In the right lung, slight increase in activity occurred only on day 5. Cellular proliferative activity was inhibited in both lungs early after injury. In the right lung, however, DNA synthesis increased to levels 10 times the controls by day 7. In the left lung, the inhibition decreased gradually after day 7, indicating increased cellular proliferation. We conclude that activation of some cellular Tyr-K may play a role in regulating early cellular proliferation during lung injury, fibrosis, and compensatory growth. JF - Experimental lung research AU - Dubaybo, B A AU - Marwah, G S AU - Fligiel, S E AU - Hatfield, J S AU - Majumdar, A P AD - Department of Medicine, Veterans Administration Medical Center, Allen Park, MI 48101. PY - 1990 SP - 257 EP - 266 VL - 16 IS - 3 SN - 0190-2148, 0190-2148 KW - DNA KW - 9007-49-2 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Enzyme Activation KW - DNA -- metabolism KW - Male KW - Cell Division KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- enzymology KW - Lung -- enzymology KW - Adaptation, Physiological KW - Protein-Tyrosine Kinases -- metabolism KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79847865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Tyrosine+kinase+activation+during+lung+injury%2C+fibrosis%2C+and+compensatory+lung+growth.&rft.au=Dubaybo%2C+B+A%3BMarwah%2C+G+S%3BFligiel%2C+S+E%3BHatfield%2C+J+S%3BMajumdar%2C+A+P&rft.aulast=Dubaybo&rft.aufirst=B&rft.date=1990-05-01&rft.volume=16&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-02 N1 - Date created - 1990-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Communication skills training, communication skills training with family and cognitive behavioral mood management training for alcoholics. AN - 79782619; 2342366 AB - To evaluate three promising social learning approaches to the treatment of alcoholism, 69 male alcoholics in standard inpatient treatment participated in either a communication skills training group (CST), a communication skills training group with family participation (CSTF) or a cognitive behavioral mood management training group (CBMMT). Alcoholics who received CST or CSTF drank significantly less alcohol per drinking day during 6-month follow-up than those in CBMMT. The groups did not differ in abstinence rates or latency to relapse. All groups improved in skill and anxiety on the extensive battery of process measures, including role-play tests of general and alcohol-specific coping skills, but those in CST improved most in skill in alcohol-specific high-risk role plays and in ability to relax after the role plays. Alcoholics' skill, response latency, anxiety and urge to drink during alcohol-specific role plays were highly correlated with treatment outcome, demonstrating the importance of including comprehensive process measures in treatment outcome research. Implications for patient-treatment matching and future research are discussed. JF - Journal of studies on alcohol AU - Monti, P M AU - Abrams, D B AU - Binkoff, J A AU - Zwick, W R AU - Liepman, M R AU - Nirenberg, T D AU - Rohsenow, D J AD - Veterans Administration Medical Center, Providence, Rhode Island. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 263 EP - 270 VL - 51 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Combined Modality Therapy KW - Adaptation, Psychological KW - Humans KW - Cohort Studies KW - Adult KW - Alcohol Drinking -- psychology KW - Family KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Recurrence KW - Male KW - Alcoholism -- rehabilitation KW - Family Therapy -- methods KW - Communication KW - Behavior Therapy -- methods KW - Alcoholism -- psychology KW - Cognitive Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79782619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Communication+skills+training%2C+communication+skills+training+with+family+and+cognitive+behavioral+mood+management+training+for+alcoholics.&rft.au=Monti%2C+P+M%3BAbrams%2C+D+B%3BBinkoff%2C+J+A%3BZwick%2C+W+R%3BLiepman%2C+M+R%3BNirenberg%2C+T+D%3BRohsenow%2C+D+J&rft.aulast=Monti&rft.aufirst=P&rft.date=1990-05-01&rft.volume=51&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-27 N1 - Date created - 1990-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Severe withdrawal symptoms after discontinuation of alprazolam in eight patients with combat-induced posttraumatic stress disorder. AN - 79761480; 2335496 AB - Eight patients with combat-induced chronic posttraumatic stress disorder (PTSD) receiving long-term alprazolam therapy for anxiety or depression (maximum dose of 2-9 mg/day for 1-5 years) had alprazolam therapy withdrawn. Most of the patients underwent gradual medication withdrawal. All patients had a prior history of alcohol abuse or benzodiazepine dependence. During withdrawal, all patients had severe reactions including anxiety, sleep disturbance, rage reactions, hyperalertness, increased nightmares, and intrusive thoughts; and 6 of the 8 patients had homicidal ideation. As a result of this report, the authors suggest that the potential for severe withdrawal reactions, even with gradual tapering, should be considered before prescribing alprazolam therapy for this group of patients. JF - The Journal of clinical psychiatry AU - Risse, S C AU - Whitters, A AU - Burke, J AU - Chen, S AU - Scurfield, R M AU - Raskind, M A AD - Psychiatry Service, American Lake Veterans Administration Medical Center, Tacoma, Wash 98493. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 206 EP - 209 VL - 51 IS - 5 SN - 0160-6689, 0160-6689 KW - Benzodiazepines KW - 12794-10-4 KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Homicide KW - Anxiety Disorders -- drug therapy KW - Depressive Disorder -- psychology KW - Anxiety Disorders -- psychology KW - Humans KW - Adult KW - Depressive Disorder -- drug therapy KW - Substance-Related Disorders -- complications KW - Rage KW - Male KW - Substance Withdrawal Syndrome -- etiology KW - Combat Disorders -- psychology KW - Substance Withdrawal Syndrome -- diagnosis KW - Combat Disorders -- drug therapy KW - Alprazolam -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79761480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Severe+withdrawal+symptoms+after+discontinuation+of+alprazolam+in+eight+patients+with+combat-induced+posttraumatic+stress+disorder.&rft.au=Risse%2C+S+C%3BWhitters%2C+A%3BBurke%2C+J%3BChen%2C+S%3BScurfield%2C+R+M%3BRaskind%2C+M+A&rft.aulast=Risse&rft.aufirst=S&rft.date=1990-05-01&rft.volume=51&rft.issue=5&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-08 N1 - Date created - 1990-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclic adenosine 3',5'-monophosphate and glucose stimulate thyroxine 5'-deiodinase type II in cultured mouse neuroblastoma cells. AN - 79758535; 2159588 AB - Nutrient modulation increases mouse neuroblastoma (NB) T4-5'-deiodinase II (T4-5'-D II) activity. Carbohydrates are more potent than either amino acids or glycerol as nutrient sources. Glucose rapidly (2 to 4 hours) enhances NB enzyme activity and the response is dependent on new protein synthesis. The present study was performed to further characterize this glucose effect and explore its relationship to the cyclic adenosine monophosphate (cAMP) system in these cells. NB T4-5'-D II activity reached a maximum level (sixfold) in response to glucose (10 mmol/L) at 16 hours and thereafter remained constant up to 22 hours before reverting back to basal level between 24 and 30 hours. This pattern of response allowed the performance of detailed studies on maximum glucose activated NB T4-5'-D II under transient equilibrium conditions during the 16- to 22-hour period. Addition of dibutyryl cAMP (dbcAMP) (1 mmol/L) at this stage significantly increased enzyme activity (twofold at 2 hours and fourfold at 4 and 6 hours) compared with glucose alone. There was an additive response to dbcAMP under these maximum glucose-activated conditions. Nonactivated NB T4-5'-D II showed a twofold response to dbcAMP (1 mmol/L) at 4 hours in a glucose-free medium. Under these conditions, glucose (10 mmol/L) also increased enzyme activity twofold. Combined studies with dbcAMP and glucose increased enzyme activity fourfold at 4 hours. Subsequent studies were performed with forskolin (10 mumol/L) and cholera toxin (1 nmol/L), modulators of endogenous cAMP.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Metabolism: clinical and experimental AU - Gavin, L A AU - Moeller, M AU - McMahon, F AU - Gulli, R AU - Cavalieri, R R AD - Division of Endocrinology-Metabolism, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 474 EP - 479 VL - 39 IS - 5 SN - 0026-0495, 0026-0495 KW - Dactinomycin KW - 1CC1JFE158 KW - Colforsin KW - 1F7A44V6OU KW - Puromycin KW - 4A6ZS6Q2CL KW - Bucladesine KW - 63X7MBT2LQ KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Dactinomycin -- pharmacology KW - Animals KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured KW - Puromycin -- pharmacology KW - Cholera Toxin -- pharmacology KW - Mice KW - Bucladesine -- pharmacology KW - Neuroblastoma -- pathology KW - Iodide Peroxidase -- metabolism KW - Glucose -- pharmacology KW - Neuroblastoma -- enzymology KW - Cyclic AMP -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79758535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Cyclic+adenosine+3%27%2C5%27-monophosphate+and+glucose+stimulate+thyroxine+5%27-deiodinase+type+II+in+cultured+mouse+neuroblastoma+cells.&rft.au=Gavin%2C+L+A%3BMoeller%2C+M%3BMcMahon%2C+F%3BGulli%2C+R%3BCavalieri%2C+R+R&rft.aulast=Gavin&rft.aufirst=L&rft.date=1990-05-01&rft.volume=39&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-08 N1 - Date created - 1990-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of inhibition of gastric secretion on antral gastrin and somatostatin gene expression in rats. AN - 79755578; 1692193 AB - Antral gastrin and somatostatin mRNA concentrations were measured in rats during gastric neutralization produced either by resection of the acid-secreting portion of the stomach (fundectomy) or by omeprazole treatment. Fundectomy caused increases in gastrin mRNA concentrations to 570% of sham control after 4 days and to 650% after 28 days. Daily administration of omeprazole resulted in significant dose- and time-dependent increases in antral gastrin mRNA concentrations. Four-day treatment with omeprazole caused threefold increased gastrin mRNA. Antral somatostatin mRNA concentrations decreased significantly after fundectomy to 66% of sham control after 4 days and to 23% after 28 days. Omeprazole produced a more profound decrease in somatostatin mRNA to 22% of the vehicle control after 4 days. Antral beta-actin mRNA concentrations did not differ significantly between control and experimental animals. Transcription of gastrin mRNA in isolated antral mucosal nuclei, measured by a nuclear run on technique, was significantly increased after omeprazole treatment in vivo. Increases in plasma and antral gastrin concentrations in response to gastric neutralization were closely associated with increases in gastrin mRNA and were accompanied by reductions in somatostatin mRNA in the antrum. However, fundectomy produced relatively greater increases in gastrin mRNA and lesser reductions in somatostatin mRNA than observed after omeprazole pretreatment. JF - The American journal of physiology AU - Wu, S V AU - Giraud, A AU - Mogard, M AU - Sumii, K AU - Walsh, J H AD - Center for Ulcer Research and Education, West Los Angeles Veterans Administration Medical Center, California. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - G788 EP - G793 VL - 258 IS - 5 Pt 1 SN - 0002-9513, 0002-9513 KW - Amanitins KW - 0 KW - Gastrins KW - RNA Probes KW - RNA, Messenger KW - Somatostatin KW - 51110-01-1 KW - RNA KW - 63231-63-0 KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Animals KW - Reference Values KW - Blotting, Northern KW - Cell Nucleus -- metabolism KW - Vagotomy KW - RNA, Messenger -- drug effects KW - RNA, Messenger -- genetics KW - Rats, Inbred Strains KW - Rats KW - Amanitins -- pharmacology KW - RNA -- isolation & purification KW - Gastrectomy KW - Male KW - RNA -- genetics KW - Gene Expression -- drug effects KW - Gastrins -- genetics KW - Somatostatin -- genetics KW - Omeprazole -- pharmacology KW - Gastric Juice -- secretion KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79755578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Effects+of+inhibition+of+gastric+secretion+on+antral+gastrin+and+somatostatin+gene+expression+in+rats.&rft.au=Wu%2C+S+V%3BGiraud%2C+A%3BMogard%2C+M%3BSumii%2C+K%3BWalsh%2C+J+H&rft.aulast=Wu&rft.aufirst=S&rft.date=1990-05-01&rft.volume=258&rft.issue=5+Pt+1&rft.spage=G788&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-07 N1 - Date created - 1990-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hodgkin's disease presenting in the skin: case report and review of the literature. AN - 79750785; 2186062 AB - Cutaneous manifestations of Hodgkin's disease are relatively uncommon. We present a case of Hodgkin's disease with widespread skin involvement and review the literature on the subject. JF - Journal of the American Academy of Dermatology AU - Hayes, T G AU - Rabin, V R AU - Rosen, T AU - Zubler, M A AD - Oncology Service, Veterans Administration Hospital, Houston, TX 77211. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 944 EP - 947 VL - 22 IS - 5 Pt 2 SN - 0190-9622, 0190-9622 KW - Procarbazine KW - 35S93Y190K KW - Mechlorethamine KW - 50D9XSG0VR KW - Vincristine KW - 5J49Q6B70F KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Procarbazine -- therapeutic use KW - Mechlorethamine -- therapeutic use KW - Vincristine -- therapeutic use KW - Prednisone -- therapeutic use KW - Humans KW - Middle Aged KW - Eczema -- etiology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Skin Diseases -- drug therapy KW - Hodgkin Disease -- pathology KW - Hodgkin Disease -- drug therapy KW - Skin Diseases -- etiology KW - Skin Diseases -- pathology KW - Hodgkin Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79750785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Hodgkin%27s+disease+presenting+in+the+skin%3A+case+report+and+review+of+the+literature.&rft.au=Hayes%2C+T+G%3BRabin%2C+V+R%3BRosen%2C+T%3BZubler%2C+M+A&rft.aulast=Hayes&rft.aufirst=T&rft.date=1990-05-01&rft.volume=22&rft.issue=5+Pt+2&rft.spage=944&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-14 N1 - Date created - 1990-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary edema associated with electrical injury. AN - 79744889; 2331923 AB - The occurrence of cardiogenic pulmonary edema following alternating current electrical injury has not been reported. A patient developing severe pulmonary edema immediately following an electrical injury-induced episode of ventricular fibrillation is described. Evidence that the etiology of the pulmonary edema was cardiogenic is derived from both hemodynamic data and the calculation of the pulmonary edema fluid to serum colloid osmotic pressure ratio. JF - Chest AU - Schein, R M AU - Kett, D H AU - De Marchena, E J AU - Sprung, C L AD - Department of Medicine, Veterans Administration Medical Center, Miami. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 1248 EP - 1250 VL - 97 IS - 5 SN - 0012-3692, 0012-3692 KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- physiology KW - Humans KW - Middle Aged KW - Accidents, Occupational KW - Male KW - Ventricular Fibrillation -- etiology KW - Pulmonary Edema -- etiology KW - Burns, Electric -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79744889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Pulmonary+edema+associated+with+electrical+injury.&rft.au=Schein%2C+R+M%3BKett%2C+D+H%3BDe+Marchena%2C+E+J%3BSprung%2C+C+L&rft.aulast=Schein&rft.aufirst=R&rft.date=1990-05-01&rft.volume=97&rft.issue=5&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-07 N1 - Date created - 1990-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies on the functional activity of the promoter for the human thyroid peroxidase gene. AN - 79729106; 2158317 AB - We isolated the initial 1.3 kb of the 5'-flanking region of the human thyroid peroxidase (hTPO) gene, and sub-cloned this fragment into the luciferase reporter gene expression plasmid pA3-LUC. This plasmid contruct (p1.3HTPO-LUC) was stably transfected into FRTL5 rat thyroid cells and NIH-3T3 fibroblasts. Promoter activity was detected in 3 of 8 FRTL5 stable cell lines obtained. TSH, dBcAMP and phorbol ester did not alter TPO promoter activity. TPO promoter activity was also expressed in 4 of 5 NIH-3T3 stably-transfected cell lines, and this activity was also not altered by dBcAMP and phorbol ester. These data support the emerging concept that the TPO gene is not transcriptionally regulated by TSH and cAMP. JF - Biochemical and biophysical research communications AU - Foti, D AU - Gestautas, J AU - Rapoport, B AD - Thyroid Molecular Biology Laboratory, Veterans' Administration Medical Center, San Francisco, California 94121. Y1 - 1990/04/16/ PY - 1990 DA - 1990 Apr 16 SP - 281 EP - 287 VL - 168 IS - 1 SN - 0006-291X, 0006-291X KW - Bucladesine KW - 63X7MBT2LQ KW - Thyrotropin KW - 9002-71-5 KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Mice KW - Bucladesine -- pharmacology KW - Rats KW - Regulatory Sequences, Nucleic Acid KW - Base Sequence KW - Thyrotropin -- pharmacology KW - Thyroid Gland -- physiology KW - In Vitro Techniques KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Promoter Regions, Genetic KW - Iodide Peroxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79729106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Studies+on+the+functional+activity+of+the+promoter+for+the+human+thyroid+peroxidase+gene.&rft.au=Foti%2C+D%3BGestautas%2C+J%3BRapoport%2C+B&rft.aulast=Foti&rft.aufirst=D&rft.date=1990-04-16&rft.volume=168&rft.issue=1&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-18 N1 - Date created - 1990-05-18 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M33232; GENBANK N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity. AN - 79692944; 2108159 AB - Hepatic lipase (HL) is a member of the lipoprotein lipase/pancreatic lipase gene family and is believed to function in processing of intermediate and high density lipoproteins. As a lipase, HL is presumed to have a lipid interfacial binding domain, distinct from the esterase catalytic site, orienting the enzyme at aqueous-lipid interfaces and resulting in activation of esterase activity. However, the structural domains responsible for these separate functions have not been identified. Amino acid sequence homology to serine proteases, thioesterases and other lipases, identified Ser147 of rat HL as part of a highly conserved element in an esterase gene family. In order to better define the function of this domain in HL, site-directed mutagenesis was utilized to produce mutant cDNAs with amino acid substitutions for Ser147, Ser133, or Ser228. Following injection of Xenopus oocytes with SP6 transcripts for normal or mutant HL, media from the oocytes were assayed for lipolytic activity and immunoprecipitable HL protein. Mutations of Ser133 and Ser228 produced no decrease in activity whereas the mutant protein in which Ser147 was replaced with glycine had little, if any activity against emulsified triolein substrates. Replacing HL Ser147 with glycine also resulted in a protein with little or no measurable activity for tributyrin, a substrate which does not provide a lipid interface. These results suggest that Ser147 in rat HL is either located at the catalytic site or is required for maintaining the structural integrity of the catalytic site. JF - The Journal of biological chemistry AU - Davis, R C AU - Stahnke, G AU - Wong, H AU - Doolittle, M H AU - Ameis, D AU - Will, H AU - Schotz, M C AD - Lipid Research, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1990/04/15/ PY - 1990 DA - 1990 Apr 15 SP - 6291 EP - 6295 VL - 265 IS - 11 SN - 0021-9258, 0021-9258 KW - Oligonucleotide Probes KW - 0 KW - RNA, Messenger KW - Serine KW - 452VLY9402 KW - Esterases KW - EC 3.1.- KW - Lipase KW - EC 3.1.1.3 KW - Index Medicus KW - Rats KW - Xenopus laevis KW - Animals KW - Esterases -- metabolism KW - Restriction Mapping KW - Oocytes -- enzymology KW - RNA, Messenger -- genetics KW - Male KW - Binding Sites KW - Liver -- enzymology KW - Lipase -- genetics KW - Mutation KW - Lipase -- metabolism KW - Lipase -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79692944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Hepatic+lipase%3A+site-directed+mutagenesis+of+a+serine+residue+important+for+catalytic+activity.&rft.au=Davis%2C+R+C%3BStahnke%2C+G%3BWong%2C+H%3BDoolittle%2C+M+H%3BAmeis%2C+D%3BWill%2C+H%3BSchotz%2C+M+C&rft.aulast=Davis&rft.aufirst=R&rft.date=1990-04-15&rft.volume=265&rft.issue=11&rft.spage=6291&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-10 N1 - Date created - 1990-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of chronic ethanol administration on total asialoglycoprotein receptor content and intracellular processing of asialoorosomucoid in isolated rat hepatocytes. AN - 79710465; 2322585 AB - Chronic ethanol administration markedly impairs the process of receptor-mediated endocytosis (RME) of a representative asialoglycoprotein, asialoorosomucoid (ASOR), by the liver (Casey et al. (1987) J. Biol. Chem. 262, 2704-2710). Decreased surface binding was the major defect reported in our initial study, along with impaired internalization and degradation of 125I-ASOR in chronically-fed ethanol animals. In this study, we further characterized these impairments by examining the content of intracellular receptors and by investigating ligand processing directed by these intracellular receptors. Ethanol administration for 5-7 weeks decreased intracellular ASOR receptor content by 40%, a result which was confirmed by using both a ligand-binding assay and an antibody-binding assay. In addition to a decreased number of intracellular receptors, an impairment in intracellular processing of receptor-ligand complexes was identified. In ethanol-fed animals, dissociation of receptor-ligand complexes was decreased during steady-state conditions of endocytosis at 37 degrees C. Impaired receptor-ligand dissociation did not alter the fate of the ligand which was to undergo diacytosis (ligand recycling), but did appear to impair degradation of intracellular ligand. These results indicate that chronic ethanol administration decreases ligand binding due to a decreased number of receptors and impairs intracellular processing of ASOR in hepatocytes. JF - Biochimica et biophysica acta AU - Casey, C A AU - Kragskow, S L AU - Sorrell, M F AU - Tuma, D J AD - Liver Study Unit, Veterans Administration Medical Center, Omaha, Nebraska 68105. Y1 - 1990/04/09/ PY - 1990 DA - 1990 Apr 09 SP - 1 EP - 8 VL - 1052 IS - 1 SN - 0006-3002, 0006-3002 KW - Asialoglycoprotein Receptor KW - 0 KW - Asialoglycoproteins KW - Ligands KW - Orosomucoid KW - Receptors, Immunologic KW - asialoorosomucoid KW - Index Medicus KW - Rats KW - Animals KW - Reference Values KW - Cell Membrane -- immunology KW - Cells, Cultured KW - Kinetics KW - Biological Transport KW - Cell Membrane -- metabolism KW - Liver -- immunology KW - Receptors, Immunologic -- metabolism KW - Orosomucoid -- metabolism KW - Orosomucoid -- analogs & derivatives KW - Liver -- metabolism KW - Alcoholism -- metabolism KW - Alcoholism -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79710465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Effect+of+chronic+ethanol+administration+on+total+asialoglycoprotein+receptor+content+and+intracellular+processing+of+asialoorosomucoid+in+isolated+rat+hepatocytes.&rft.au=Casey%2C+C+A%3BKragskow%2C+S+L%3BSorrell%2C+M+F%3BTuma%2C+D+J&rft.aulast=Casey&rft.aufirst=C&rft.date=1990-04-09&rft.volume=1052&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Esophageal involvement by cutaneous T-cell lymphoma, mycosis fungoides type: diagnosis by endoscopic biopsy. AN - 85197323; pmid-2324481 AB - A patient with long-standing cutaneous T-cell lymphoma, mycosis fungoides type (CTCL-MF), developed dysphagia, odynophagia, and weight loss. Endoscopic biopsy of esophageal mucosa demonstrated involvement by CTCL-MF. Although extracutaneous spread of CTCL-MF is common, esophageal involvement is unusual and to our knowledge has not previously been diagnosed antemortem. JF - Journal of Clinical Gastroenterology AU - Kim, O D AU - Cantave, I AU - Schlesinger, P K AD - Department of Medicine, Veterans Administration, West Side Medical Center, Chicago, IL 60612. PY - 1990 SP - 178 EP - 182 VL - 12 IS - 2 SN - 0192-0790, 0192-0790 KW - Deglutition Disorders KW - Human KW - Esophageal Neoplasms KW - Weight Loss KW - Middle Age KW - Microscopy, Electron KW - Case Report KW - Pain KW - Biopsy KW - Mycosis Fungoides KW - Esophagoscopy KW - Deglutition KW - Male KW - T-Lymphocytes KW - Skin Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85197323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Esophageal+involvement+by+cutaneous+T-cell+lymphoma%2C+mycosis+fungoides+type%3A+diagnosis+by+endoscopic+biopsy.&rft.au=Kim%2C+O+D%3BCantave%2C+I%3BSchlesinger%2C+P+K&rft.aulast=Kim&rft.aufirst=O&rft.date=1990-04-01&rft.volume=12&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. AN - 80240816; 2177844 AB - Differentiation of mouse embryonal carcinoma cells to the parietal endoderm phenotype is associated with expression of PTH-responsive adenylate cyclase. A PTH-like protein (PLP), which binds to PTH receptors and activates adenylate cyclase in classical PTH target cells was recently isolated and cloned. We assessed whether the parietal endoderm phenotype is associated with the expression of PLP or its receptor. A 1.4-kilobase PLP transcript was detected in the mouse parietal endoderm cell line PYS-2. No hybridizing transcripts were evident in undifferentiated mouse embryonal carcinoma cells PSA-1 or F9. However, differentiation of these cells to parietal endoderm, either spontaneously (PSA-1) or by treatment with retinoic acid and dibutyryl cAMP (F9), resulted in expression of the 1.4-kilobase PLP message. Undifferentiated F9 cells displayed negligible specific binding of [125I]PLP-(1-34)amide. When F9 cells were induced to differentiate to parietal endoderm, specific binding sites for [125I]PLP-(1-34)amide were expressed in parallel with PLP-responsive adenylate cyclase. These receptors, like those in classical PTH target tissues, displayed identical affinity (Kd = 5.2 nM) for bPTH-(1-34) and hPLP-(1-34)amide; with binding capacity (Bmax) of 6.6 x 10(4) sites/cell. In the presence of retinoic acid, exogenous PLP substituted for dibutyryl cAMP in a concentration-dependent fashion in promoting the differentiation of F9 cells to parietal endoderm. Thus, both PLP mRNA and PLP receptors coupled to adenylate cyclase are expressed during the differentiation of mouse embryonal carcinoma cells. Increased cAMP levels produced by autocrine stimulation of PLP receptors by PLP may contribute to differentiation of embryonal carcinoma cells into parietal endoderm. JF - Molecular endocrinology (Baltimore, Md.) AU - Chan, S D AU - Strewler, G J AU - King, K L AU - Nissenson, R A AD - Endocrine Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 638 EP - 646 VL - 4 IS - 4 SN - 0888-8809, 0888-8809 KW - Neoplasm Proteins KW - 0 KW - Parathyroid Hormone-Related Protein KW - Peptide Fragments KW - Proteins KW - RNA, Messenger KW - RNA, Neoplasm KW - Receptors, Cell Surface KW - Receptors, Parathyroid Hormone KW - parathyroid hormone-related protein (1-34) KW - 112540-82-6 KW - Tretinoin KW - 5688UTC01R KW - Bucladesine KW - 63X7MBT2LQ KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - RNA, Neoplasm -- biosynthesis KW - Peptide Fragments -- metabolism KW - Tretinoin -- pharmacology KW - Animals KW - Tumor Cells, Cultured -- drug effects KW - Mice KW - Endoderm -- pathology KW - Bucladesine -- pharmacology KW - Proteins -- metabolism KW - RNA, Messenger -- biosynthesis KW - Neoplasm Proteins -- pharmacology KW - Proteins -- pharmacology KW - Peptide Fragments -- pharmacology KW - Tumor Cells, Cultured -- pathology KW - Cell Differentiation -- drug effects KW - Neoplasm Proteins -- metabolism KW - Receptors, Cell Surface -- metabolism KW - Teratoma -- metabolism KW - Teratoma -- genetics KW - Protein Biosynthesis KW - Teratoma -- pathology KW - Adenylyl Cyclases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80240816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Expression+of+a+parathyroid+hormone-like+protein+and+its+receptor+during+differentiation+of+embryonal+carcinoma+cells.&rft.au=Chan%2C+S+D%3BStrewler%2C+G+J%3BKing%2C+K+L%3BNissenson%2C+R+A&rft.aulast=Chan&rft.aufirst=S&rft.date=1990-04-01&rft.volume=4&rft.issue=4&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-08 N1 - Date created - 1991-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of rifampicin on the in-vitro activity of cefpirome or ceftazidime in combination with aminoglycosides against Pseudomonas aeruginosa. AN - 79819291; 2112539 AB - The in-vitro activity of cefpirome and ceftazidime when combined with aminoglycosides (gentamicin, amikacin, and tobramycin) in the presence and in the absence of rifampicin was evaluated against 32 isolates of Pseudomonas aeruginosa by two methods. Agar dilution susceptibilities demonstrated a marked reduction in synergy (FIC less than or equal to 0.5) when rifampicin was added to the combination. Synergy rates decreased from 59.4-84.4% without to 3.1-9.4% with the addition of rifampicin. In contrast, kill curve tests performed on two P. aeruginosa strains demonstrated synergy at 24 h when rifampicin was added to cefpirome, ceftazidime, gentamicin or a beta-lactam agent plus gentamicin combination. The addition of rifampicin to the combinations of cefpirome or ceftazidime plus gentamicin achieved a 2-log10 lower bacterial count at 24 h than that of the beta-lactam and gentamicin combination alone. When rifampicin was added to the combination cefpirome or ceftazidime plus gentamicin at different times during incubation, a greater bactericidal effect was observed when rifampicin was added at 0 and 1 h of incubation than when added later. No antagonism was observed with rifampicin when used in combination with beta-lactam agents and/or aminoglycosides. JF - The Journal of antimicrobial chemotherapy AU - Valdes, J M AU - Baltch, A L AU - Smith, R P AU - Hammer, M C AU - Ritz, W J AD - Department of Medicine, Veterans Administration Medical Center, Albany, New York. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 575 EP - 584 VL - 25 IS - 4 SN - 0305-7453, 0305-7453 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Cephalosporins KW - Ceftazidime KW - 9M416Z9QNR KW - cefpirome KW - S72Q2F09HY KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Drug Interactions KW - Drug Therapy, Combination -- pharmacology KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Cephalosporins -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Pseudomonas aeruginosa -- drug effects KW - Ceftazidime -- pharmacology KW - Rifampin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79819291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=The+effect+of+rifampicin+on+the+in-vitro+activity+of+cefpirome+or+ceftazidime+in+combination+with+aminoglycosides+against+Pseudomonas+aeruginosa.&rft.au=Valdes%2C+J+M%3BBaltch%2C+A+L%3BSmith%2C+R+P%3BHammer%2C+M+C%3BRitz%2C+W+J&rft.aulast=Valdes&rft.aufirst=J&rft.date=1990-04-01&rft.volume=25&rft.issue=4&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-16 N1 - Date created - 1990-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Estimation of genetic correlation: interpretation of experiments using selectively bred and inbred animals. AN - 79817738; 2190477 AB - There is increasing interest in determining the extent to which multiple characters related to drug sensitivity are influenced by common genes. The principal method for testing for the existence of such genetic correlations has been examination of pairs of mouse or rat lines selectively bred for sensitivity or resistance to a single behavioral effect of a drug. When a pair of selected lines is found to differ significantly on some trait other than the one on which they were selected, it is commonly concluded that significant genetic correlation between the traits exists, implying the action of a common set of genes on the two responses. In addition, results from comparisons of lines of animals selected for trait X and tested for trait Y may be compared with results from lines selected for trait Y and tested for trait X. As the number of correlated responses in selected lines increases, it becomes more important to adhere to sensible, consensual guidelines for interpreting such line differences. The principles underlying phenotypic and genotypic correlational analyses with selected lines are discussed. A scheme is presented to allow standardization across laboratories of inferences about the relative strength of genetic association from experiments with selected lines. Statistical and practical experimental issues are addressed. Estimates of genetic correlations may also be derived from the correlation of mean trait values across a panel of inbred strains. Existing data have sometimes found estimates of genetic correlations made with one approach to be inconsistent with those estimated in other ways. Possible reasons for this are discussed. Finally, the relationship between phenotypic correlations and genetic correlations is discussed. Phenotypic and genetic correlations for a pair of traits may differ widely, and may even be opposite in sign. Both are characteristic of the population from which they are sampled. Phenotypic correlations estimated within selected lines may change over time, as the additive genetic variance in the selected trait is exhausted. A specific example of this phenomenon is given. JF - Alcoholism, clinical and experimental research AU - Crabbe, J C AU - Phillips, T J AU - Kosobud, A AU - Belknap, J K AD - Research Service, Veterans Administration Medical Center, Portland, OR 97201. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 141 EP - 151 VL - 14 IS - 2 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Models, Genetic KW - Mice KW - Genetic Variation -- genetics KW - Alcoholic Intoxication -- genetics KW - Phenotype KW - Genotype KW - Alcoholism -- genetics KW - Selection, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79817738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Estimation+of+genetic+correlation%3A+interpretation+of+experiments+using+selectively+bred+and+inbred+animals.&rft.au=Crabbe%2C+J+C%3BPhillips%2C+T+J%3BKosobud%2C+A%3BBelknap%2C+J+K&rft.aulast=Crabbe&rft.aufirst=J&rft.date=1990-04-01&rft.volume=14&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-09 N1 - Date created - 1990-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prone position reverses gravitational distribution of perfusion in dog lungs with oleic acid-induced injury. AN - 79798848; 2347780 AB - Although oxygenation improves in patients with the adult respiratory distress syndrome and in animals with oleic acid- (OA) induced acute lung injury when they are turned from the supine to the prone position, the mechanism(s) by which this improvement occurs is not known. Several groups have speculated that this improvement results from preferential edema accumulation in the dorsal lung regions and redistribution of perfusion away from these regions when the patients are turned to the prone position. We used radiolabeled microspheres to measure the regional distribution of perfusion (Qr) to the dorsal, mid, and ventral lungs of eight dogs in vivo in the supine and prone positions, before and after inducing acute lung injury with OA, and correlated the Qr observed after injury with the degree of regional extravascular lung water (EVLWr). Before OA, Qr increased along the gravitational gradient when the animals were supine but was more uniformly distributed when they were prone. After OA, Qr again followed a gravitational gradient when the animals were supine but was preferentially distributed to the nondependent regions when they were prone. EVLWr was similar in all regions, regardless of whether OA was injected when the animals were supine or prone. The gravitational Qr gradient is markedly reduced in the prone position, both before and after lung injury. The prone position-induced improvement in oxygenation is not the result of redistribution of Qr away from areas in which edema preferentially develops. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Wiener, C M AU - Kirk, W AU - Albert, R K AD - Veterans Administration Medical Center, Seattle, Washington. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 1386 EP - 1392 VL - 68 IS - 4 SN - 8750-7587, 8750-7587 KW - Cerium Radioisotopes KW - 0 KW - Oleic Acids KW - Radioisotopes KW - Ruthenium Radioisotopes KW - Niobium KW - 05175J654G KW - Oleic Acid KW - 2UMI9U37CP KW - Scandium KW - YUJ4U1EW7R KW - Index Medicus KW - Space life sciences KW - Animals KW - Cardiac Output KW - Extravascular Lung Water -- physiology KW - Microspheres KW - Gravitation KW - Dogs KW - Pulmonary Edema -- chemically induced KW - Pulmonary Edema -- physiopathology KW - Lung -- blood supply KW - Lung Diseases -- chemically induced KW - Lung Diseases -- physiopathology KW - Posture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79798848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Prone+position+reverses+gravitational+distribution+of+perfusion+in+dog+lungs+with+oleic+acid-induced+injury.&rft.au=Wiener%2C+C+M%3BKirk%2C+W%3BAlbert%2C+R+K&rft.aulast=Wiener&rft.aufirst=C&rft.date=1990-04-01&rft.volume=68&rft.issue=4&rft.spage=1386&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-11 N1 - Date created - 1990-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the synergistic antiproliferative effects of interferon-gamma and tumor necrosis factor on human colon carcinoma cell lines. AN - 79783486; 2111352 AB - We employed a tumor-type-specific tissue culture model utilizing three human colon carcinoma cell lines to (i) assess the effects of schedule, sequence, dose, and duration of exposure on the antiproliferative activity of combinations of tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) and to (ii) determine the effects of this combination on the production of a TNF-inducible protein, IFN-beta 2, and an IFN-inducible protein, p78. A statistical model was developed to ascertain the effects of each of three of the variables (sequence, dose, and duration) on the other two. With minor exceptions, the maximal antiproliferative effect in all three cell lines was observed when IFN-gamma and TNF were administered simultaneously, regardless of the doses of each agent and duration of exposure. Exposing the cells to TNF before IFN-gamma resulted in the least inhibition in cell growth. In all three cell lines, the antiproliferative effects of each treatment group were related directly to the duration of exposure. In two of the three cell lines, an intermittent schedule was as effective as a 24-h exposure. No p78 induction was observed in the HCT 116 cell line with IFN-gamma alone, TNF alone, or the combination; p78 was slightly induced in the SKC01 and VACO 9P cell lines with IFN-gamma alone, and was synergistically induced by the combination of TNF and IFN-gamma. Treatment with a neutralizing antibody to IFN-beta did not reverse the antiproliferative effect of any of the three treatment groups in HCT 116 cells. We conclude that the maximum antiproliferative effect in human colon carcinoma can be achieved by the prolonged simultaneous administration of high concentrations of each drug. If clinical toxicity prohibits this schedule, an intermittent schedule of administration may be effective. The mechanism of the synergistic effect is not due to the induction of IFN-beta or the p78 protein. JF - Journal of interferon research AU - Schiller, J H AU - Storer, B AU - Bittner, G AU - Horisberger, M A AD - William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 129 EP - 139 VL - 10 IS - 2 SN - 0197-8357, 0197-8357 KW - Interferon Type I KW - 0 KW - Myxovirus Resistance Proteins KW - Neoplasm Proteins KW - Tumor Necrosis Factor-alpha KW - Interferon-gamma KW - 82115-62-6 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Protein Biosynthesis KW - Neoplasm Proteins -- biosynthesis KW - Interferon Type I -- biosynthesis KW - Humans KW - Colonic Neoplasms -- drug therapy KW - Cell Division -- drug effects KW - Statistics as Topic KW - Drug Synergism KW - Time Factors KW - Tumor Cells, Cultured -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Interferon-gamma -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79783486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+research&rft.atitle=Characterization+of+the+synergistic+antiproliferative+effects+of+interferon-gamma+and+tumor+necrosis+factor+on+human+colon+carcinoma+cell+lines.&rft.au=Schiller%2C+J+H%3BStorer%2C+B%3BBittner%2C+G%3BHorisberger%2C+M+A&rft.aulast=Schiller&rft.aufirst=J&rft.date=1990-04-01&rft.volume=10&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Genetics and diet: synergism in hepatocarcinogenesis in rats. AN - 79768897; 2159963 AB - In previous studies we have shown that male rats carrying genes controlling growth and reproduction (grc) linked to the major histocompatibility complex (MHC) to be more susceptible to N-2-acetylaminofluorene than rats without grc genes. In the present studies we show that by manipulation of the diet of grc rats, hepatocarcinogenesis induced by another carcinogen can be altered. Male rats with the grc gene (R16) and wild type (ACP) were initiated with diethylnitrosamine (DEN) (200 mg/kg body weight). Some were fed laboratory chow (LC) for 9 months; others were fed a choline-supplemented (CS) or a choline-deficient (CD) diet. The rats were killed at various time periods and the liver sections were stained with H&E and for gamma-glutamyltranspeptidase (GGT). After 9 months on LC, the livers of R16 showed greater size and number of GGT-positive foci, bile duct proliferation, cellular atypia, cirrhosis, and nodular hyperplasia than the ACP. While the first hepatocellular carcinoma in R16 fed either a CS or LC was seen at 9-10 months, one R16 rat fed a CD diet had liver cancer at 4 months. On a CS diet the R16 showed greater GGT-positive foci at 2 months than the ACP. On a CD diet the R16 showed even greater size and number of GGT-positive foci. At 12 months, 15 of 22 (68%) of the R16 rats on a CD diet had liver cancer and seven of 24 (29%) of the R16 on a CS diet. Of the ACP, none of 15 (0%) on CS and one of 18 (6%) on CD diet had liver tumors. The results show that the grc genes confer high susceptibility to liver cancer, which is enhanced by a CD diet, suggesting synergism between genetics and diet. JF - Journal of the American College of Nutrition AU - Melhem, M F AU - Kazanecki, M E AU - Rao, K N AU - Kunz, H W AU - Gill, T J AD - Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 168 EP - 173 VL - 9 IS - 2 SN - 0731-5724, 0731-5724 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Rats KW - Animals KW - Genes KW - Male KW - Cell Division KW - Major Histocompatibility Complex -- genetics KW - Choline -- administration & dosage KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- chemically induced KW - Diet KW - Carcinoma, Hepatocellular -- chemically induced KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79768897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Nutrition&rft.atitle=Genetics+and+diet%3A+synergism+in+hepatocarcinogenesis+in+rats.&rft.au=Melhem%2C+M+F%3BKazanecki%2C+M+E%3BRao%2C+K+N%3BKunz%2C+H+W%3BGill%2C+T+J&rft.aulast=Melhem&rft.aufirst=M&rft.date=1990-04-01&rft.volume=9&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Nutrition&rft.issn=07315724&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-21 N1 - Date created - 1990-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. AN - 79755952; 2333961 AB - There is evidence of crucial central nervous system involvement in the pathogenesis of mineralocorticoid-excess salt hypertension, as well as data indicating that corticosterone is the predominant ligand for the type I adrenocorticoid receptor in the brain. Miniosmotic pumps were used to deliver artificial cerebrospinal fluid (CSF), aldosterone (10 ng/h), corticosterone (10 or 20 ng/h), aldosterone (10 ng/h) plus corticosterone [10 ng/h intracerebroventricularly (icv)], or aldosterone (10 ng/h) plus corticosterone (20 ng/h icv). All animals were sensitized to mineralocorticoid hypertension by removing the right kidney and offering saline to drink. Indirect blood pressure by the unheated tail-cuff method and weights were measured twice weekly; 24-h urine volumes were measured once a week. The blood pressures of the four groups did not differ statistically before infusion. The blood pressures of those animals receiving CSF or corticosterone were not significantly elevated after 4-5 wk of intracerebroventricular infusion, whereas the aldosterone group had become significantly elevated within 2 wk. A similar study was done comparing the effects of intracerebroventricular infusion of aldosterone (10 ng/h), aldosterone (10 ng/h) and RU26988 (20 ng/h), and RU26988 (20 ng/h). RU26988, a selective type II receptor agonist, had no effect on the blood pressure, nor did it alter the pressor effect of intracerebroventricular aldosterone. The concomitant infusion of corticosterone antagonized the increase in blood pressure in a dose-dependent manner. Neither steroid nor their combinations produced significant differences in daily urine volume or body weight gain compared with the CSF group. JF - The American journal of physiology AU - Gómez-Sánchez, E P AU - Venkataraman, M T AU - Thwaites, D AU - Fort, C AD - Research Service, J. A. Haley Veterans Administration Hospital, Tampa, Florida. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - E649 EP - E653 VL - 258 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Aldosterone KW - 4964P6T9RB KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Nephrectomy KW - Aldosterone -- pharmacology KW - Blood Pressure -- drug effects KW - Male KW - Injections, Intraventricular KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Hypertension -- prevention & control KW - Cerebral Ventricles -- physiology KW - Corticosterone -- pharmacology KW - Corticosterone -- administration & dosage KW - Cerebral Ventricles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79755952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=ICV+infusion+of+corticosterone+antagonizes+ICV-aldosterone+hypertension.&rft.au=G%C3%B3mez-S%C3%A1nchez%2C+E+P%3BVenkataraman%2C+M+T%3BThwaites%2C+D%3BFort%2C+C&rft.aulast=G%C3%B3mez-S%C3%A1nchez&rft.aufirst=E&rft.date=1990-04-01&rft.volume=258&rft.issue=4+Pt+1&rft.spage=E649&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-05 N1 - Date created - 1990-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of iron on production of a possible virulence factor by Plesiomonas shigelloides. AN - 79740314; 2332475 AB - Plesiomonas shigelloides, when grown in an iron-poor medium (syncase), produces a substances that causes elongation of Chinese hamster ovary (CHO) cells similar to that produced by cholera toxin. When syncase is supplemented with iron, the ability of P. shigelloides (but not of Vibrio cholerae) to produce this elongation of CHO cells is lost. Iron depletion of the growth medium appears to be essential for the CHO cell elongation produced by P. shigelloides but is not essential for the production of toxin by V. cholerae. The possible role of iron regulation of this potential virulence factor warrants further study. JF - Journal of clinical microbiology AU - Gardner, S E AU - Fowlston, S E AU - George, W L AD - Medical Service, West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 811 EP - 813 VL - 28 IS - 4 SN - 0095-1137, 0095-1137 KW - Bacterial Toxins KW - 0 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Virulence KW - Animals KW - Cells, Cultured KW - Bacterial Toxins -- toxicity KW - Cricetinae KW - Vibrionaceae -- pathogenicity KW - Iron -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79740314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Effect+of+iron+on+production+of+a+possible+virulence+factor+by+Plesiomonas+shigelloides.&rft.au=Gardner%2C+S+E%3BFowlston%2C+S+E%3BGeorge%2C+W+L&rft.aulast=Gardner&rft.aufirst=S&rft.date=1990-04-01&rft.volume=28&rft.issue=4&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-04 N1 - Date created - 1990-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1974 Aug;10(2):320-7 [4368545] Infect Immun. 1978 Mar;19(3):785-91 [417030] J Bacteriol. 1979 Apr;138(1):193-200 [108250] J Infect Dis. 1987 Nov;156(5):720-2 [3655401] Infect Immun. 1982 Mar;35(3):1151-4 [7040247] J Infect Dis. 1982 Dec;146(6):763-9 [6754826] J Clin Microbiol. 1981 Nov;14(5):463-72 [7309844] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. AN - 79731436; 2328954 AB - Transforming growth factor beta has a specific stimulatory effect on collagen formation by hepatic lipocytes, a cell type believed to be a major source of extracellular matrices in the liver. Because monocytes and macrophages are the known sources of transforming growth factor beta, Kupffer cells--resident macrophages in the liver--may also play an important role in liver fibrogenesis by releasing this cytokine and stimulating lipocyte collagen production. The present study tested this hypothesis using Kupffer cells and hepatic lipocytes isolated from a rat model of alcoholic liver fibrosis. Kupffer-cell-conditioned medium derived from the rat liver with alcoholic fibrosis, but not that from pair-fed control animals, significantly stimulated the net collagen formation of lipocytes isolated from the alcohol-fed, pair-fed control and chow-fed animals. Acidification of the Kupffer-cell-conditioned medium potentiated this effect threefold to fourfold, indicating the presence of a latent form. Fractionation of the Kupffer-cell-conditioned medium by high-performance liquid chromatography gel filtration revealed the major peak of the stimulatory activity corresponding to the molecular weight between 20 kD and 30 kD. It was completely inhibited by anti-transforming growth factor beta IgG. Furthermore, Northern blotting and hybridization of Kupffer-cell messenger RNA from alcohol-fed rats with 32P-labeled transforming growth factor beta complementary DNA demonstrated the presence of 2.5 kb messenger RNA for this cytokine. We conclude that: (a) Kupffer cells isolated from the rat liver with alcoholic fibrosis express and release transforming growth factor beta; (b) that this cytokine is largely responsible for the Kupffer-cell-conditioned medium-induced stimulation of collagen formation by hepatic lipocytes; and (c) that this may represent a possible molecular mechanism of lipocyte stimulation during alcoholic liver fibrogenesis. JF - Hepatology (Baltimore, Md.) AU - Matsuoka, M AU - Tsukamoto, H AD - Hepatopancreatic Research Laboratory, Veterans Administration Medical Center, Martinez, CA 94553. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 599 EP - 605 VL - 11 IS - 4 SN - 0270-9139, 0270-9139 KW - Culture Media KW - 0 KW - RNA, Messenger KW - Transforming Growth Factors KW - 76057-06-2 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Rats KW - Animals KW - Cells, Cultured KW - Hydrogen-Ion Concentration KW - RNA, Messenger -- isolation & purification KW - Male KW - Lipid Metabolism KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Liver -- pathology KW - Liver Cirrhosis, Alcoholic -- etiology KW - Liver -- metabolism KW - Kupffer Cells -- metabolism KW - Collagen -- biosynthesis KW - Transforming Growth Factors -- physiology KW - Transforming Growth Factors -- metabolism KW - Transforming Growth Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79731436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Stimulation+of+hepatic+lipocyte+collagen+production+by+Kupffer+cell-derived+transforming+growth+factor+beta%3A+implication+for+a+pathogenetic+role+in+alcoholic+liver+fibrogenesis.&rft.au=Matsuoka%2C+M%3BTsukamoto%2C+H&rft.aulast=Matsuoka&rft.aufirst=M&rft.date=1990-04-01&rft.volume=11&rft.issue=4&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-25 N1 - Date created - 1990-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vancomycin-associated exfoliative dermatitis. AN - 79729371; 2139270 AB - We describe a 51-year-old patient with endstage renal disease who developed vancomycin-associated exfoliative dermatitis. After four weeks of vancomycin hydrochloride treatment for staphylococcal pericarditis this patient developed a hypersensitivity reaction characterized by intermittent fevers, lymphadenopathy, peripheral eosinophilia, and exfoliative dermatitis. The reaction persisted for five weeks, probably because of inability to rapidly eliminate vancomycin secondary to underlying renal failure. Maculopapular rashes have been reported in two to six percent of patients who receive this drug, with severe skin reactions rarely reported. In addition to this case report, a review of the literature including 11 Eli Lilly/Food and Drug Administration case reports is presented. Although severe skin reactions to vancomycin rarely occur, they prolong morbidity, particularly in patients with renal failure. JF - DICP : the annals of pharmacotherapy AU - Forrence, E A AU - Goldman, M P AD - Pharmacy Service, Veterans Administration Medical Center, Cleveland, OH 44106. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 369 EP - 371 VL - 24 IS - 4 SN - 1042-9611, 1042-9611 KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Humans KW - Skin -- pathology KW - Middle Aged KW - Male KW - Vancomycin -- adverse effects KW - Dermatitis, Exfoliative -- chemically induced KW - Dermatitis, Exfoliative -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79729371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DICP+%3A+the+annals+of+pharmacotherapy&rft.atitle=Vancomycin-associated+exfoliative+dermatitis.&rft.au=Forrence%2C+E+A%3BGoldman%2C+M+P&rft.aulast=Forrence&rft.aufirst=E&rft.date=1990-04-01&rft.volume=24&rft.issue=4&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=DICP+%3A+the+annals+of+pharmacotherapy&rft.issn=10429611&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prolonged presence of metabolite in urine after compulsive cocaine use. AN - 79713820; 2182612 AB - The authors studied the pattern of benzoylecgonine excretion in 35 male veterans who had recently used large amounts of cocaine. Following admission to a drug-free environment, the veterans completed a short structured interview and gave daily urine samples for benzoylecgonine analysis. Eleven (31.4%) patients excreted benzoylecgonine at levels of 300 ng/mL or above for 120 hours or longer after admission. Eight (22.9%) patients whose enzyme-multiplied immunoassay test results were negative subsequently tested positive. These findings corroborate recent case reports of prolonged presence of benzoylecgonine in the urine and have important implications for drug treatment programs. JF - The Journal of clinical psychiatry AU - Burke, W M AU - Ravi, N V AU - Dhopesh, V AU - Vandegrift, B AU - Maany, I AD - Department of Psychiatry, Philadelphia Veterans Administration Medical Center. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 145 EP - 148 VL - 51 IS - 4 SN - 0160-6689, 0160-6689 KW - benzoylecgonine KW - 5353I8I6YS KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Humans KW - Adult KW - Chromatography, Thin Layer KW - Time Factors KW - Male KW - Immunoenzyme Techniques KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Cocaine -- analogs & derivatives KW - Cocaine -- urine KW - Substance-Related Disorders -- urine KW - Cocaine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79713820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prolonged+presence+of+metabolite+in+urine+after+compulsive+cocaine+use.&rft.au=Burke%2C+W+M%3BRavi%2C+N+V%3BDhopesh%2C+V%3BVandegrift%2C+B%3BMaany%2C+I&rft.aulast=Burke&rft.aufirst=W&rft.date=1990-04-01&rft.volume=51&rft.issue=4&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-11 N1 - Date created - 1990-05-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Psychiatry. 1990 Aug;51(8):347 [2380162] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical importance of age at onset in type 1 and type 2 primary alcoholics. AN - 79705212; 2322083 AB - Alcoholics have been proposed to be comprised of subtypes who differ in their age at onset and in type 1 vs type 2 characteristics. This study examined whether the clinical course of primary alcoholics was associated with age at onset as well as the type 1-vs-type 2 classification scheme. Interviews with 171 consecutive primary alcoholic men entering an alcohol treatment program revealed that age at onset of alcoholism was correlated with alcohol, drug, and childhood criminality problem histories. Neither classification of these alcoholics into discrete type 1 and type 2 categories nor placing them along a continuum of type 2 characteristics was consistently associated with severity of clinical histories. These findings underscore the clinical importance of age at onset and suggest the possibility that the type 2 prototype might represent a separate diagnosis, antisocial personality disorder, and not alcoholism itself. JF - Archives of general psychiatry AU - Irwin, M AU - Schuckit, M AU - Smith, T L AD - Department of Psychiatry, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 320 EP - 324 VL - 47 IS - 4 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Age Factors KW - Diagnosis, Differential KW - Crime KW - Humans KW - Adult KW - Middle Aged KW - Child KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- classification KW - Child Behavior Disorders -- diagnosis KW - Male KW - Alcoholism -- diagnosis KW - Alcoholism -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79705212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Clinical+importance+of+age+at+onset+in+type+1+and+type+2+primary+alcoholics.&rft.au=Irwin%2C+M%3BSchuckit%2C+M%3BSmith%2C+T+L&rft.aulast=Irwin&rft.aufirst=M&rft.date=1990-04-01&rft.volume=47&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-30 N1 - Date created - 1990-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diagnosis of delayed cerebral radiation necrosis following proton beam therapy. AN - 79702822; 2157383 AB - A 27-year-old man developed delayed cerebral radiation necrosis following proton beam therapy to an arteriovenous malformation. Neuroimaging with technetium 99m diethylenetriamine penta-acetic acid and positron emission tomographic scanning with fludeoxyglucose F 18 aided in his evaluation. Significant improvement of his neurologic deficits resulted from corticosteroid therapy. Clinical resolution was corroborated by serial computed tomographic scans demonstrating regression of the abnormality (a mass lesion). Various facets of radiation injury are discussed, including pathogenesis, risk factors, diagnosis, and therapy. JF - Archives of neurology AU - Kaufman, M AU - Swartz, B E AU - Mandelkern, M AU - Ropchan, J AU - Gee, M AU - Blahd, W H AD - Department of Neurology, Wadsworth Veterans Administration Medical Center, Los Angeles, Calif. 90073. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 474 EP - 476 VL - 47 IS - 4 SN - 0003-9942, 0003-9942 KW - Protons KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Necrosis KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Tomography, Emission-Computed KW - Male KW - Intracranial Arteriovenous Malformations -- radiotherapy KW - Brain -- radiation effects KW - Brain -- diagnostic imaging KW - Radiation Injuries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79702822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Diagnosis+of+delayed+cerebral+radiation+necrosis+following+proton+beam+therapy.&rft.au=Kaufman%2C+M%3BSwartz%2C+B+E%3BMandelkern%2C+M%3BRopchan%2C+J%3BGee%2C+M%3BBlahd%2C+W+H&rft.aulast=Kaufman&rft.aufirst=M&rft.date=1990-04-01&rft.volume=47&rft.issue=4&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-02 N1 - Date created - 1990-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of hepatic vein catheterization in the evaluation of patients with anasarca. AN - 79701735; 2321666 AB - In patients with anasarca, the relative importance of cardiac, pulmonary and/or hepatic dysfunction is often difficult to determine. Conventional use of the Swan-Ganz catheter helps to separate the contributions of right and left heart disease, but it is seldom used to evaluate liver dysfunction. This report describes passage of a Swan-Ganz catheter into the hepatic vein prior to pulmonary artery placement in 11 patients. Hepatic vein catheterization permitted wedged hepatic venography using contrast media and measurement of the wedged and free hepatic venous pressures. All 11 patients had pulmonary hypertension; three had cor pulmonale only, and the others had combinations of left and right heart failure. In addition, six patients had either a cirrhotic pattern on venography, or portal hypertension. Only three of these six patients had previous clinical evidence of liver disease. This study does not prove that identification of hepatic dysfunction by this method improves the outcome in such patients. However, this low risk modification of standard pulmonary artery catheterization provides additional information which is clinically useful in searching for and avoiding complications of cirrhosis, as well as offering a clearer understanding of pathophysiology in acute multisystem disease. JF - The American journal of the medical sciences AU - Insel, J M AU - Mookherjee, S AU - Smulyan, H AU - Warner, R A AD - Department of Medicine, Cardiology Section, Veterans Administration Medical Center, Syracuse, New York. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 245 EP - 249 VL - 299 IS - 4 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Liver Cirrhosis, Alcoholic -- complications KW - Hypertension, Portal -- diagnosis KW - Ascites -- etiology KW - Venous Pressure KW - Hepatomegaly -- diagnosis KW - Humans KW - Heart Failure -- complications KW - Phlebography KW - Hemodynamics KW - Liver Cirrhosis, Alcoholic -- diagnosis KW - Hypertension, Portal -- complications KW - Hepatomegaly -- complications KW - Ascites -- diagnosis KW - Edema -- complications KW - Edema -- diagnosis KW - Catheterization, Swan-Ganz KW - Hepatic Veins -- diagnostic imaging KW - Edema -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79701735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Use+of+hepatic+vein+catheterization+in+the+evaluation+of+patients+with+anasarca.&rft.au=Insel%2C+J+M%3BMookherjee%2C+S%3BSmulyan%2C+H%3BWarner%2C+R+A&rft.aulast=Insel&rft.aufirst=J&rft.date=1990-04-01&rft.volume=299&rft.issue=4&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-04 N1 - Date created - 1990-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathogenesis of Campylobacter fetus infections. Role of surface array proteins in virulence in a mouse model. AN - 79694911; 2318963 AB - We developed a mouse model to compare the virulence of Campylobacter fetus strains with (S-plus) and without (S-minus) surface array protein (S-protein) capsules. In adult HA/ICR mice pretreated with ferric chloride, the LD50 for S-plus strain 84-32 was 43.3 times lower than its spontaneous S-minus mutant 84-54. Seven strains of inbred mice were no more susceptible than the outbred strain. In contrast to the findings with Salmonella typhimurium by others, 3 X 10(7) CFU of strain 84-32 caused 90% mortality in C3H/HeN (LPSn) mice and 40% mortality in C3H/HeJ (LPSd) mice. High-grade bacteremia in HA/ICR mice occurred after oral challenge with S-plus C. fetus strains and continued for at least 2 d, but was not present in any mice challenged with S-minus strains. Bacteremia at 30 min after challenge was 51.6-fold lower in mice pretreated with 10 microliters of rabbit antiserum to purified S-protein than after pretreatment with normal rabbit serum. Challenge of mice with a mixture of S-minus strain 84-54 and free S-proteins at a concentration 31.1-fold higher than found in wild-type strain 84-32 caused 30% mortality, compared with 0% with strain 84-54 or S-protein alone. These findings in a mouse model point toward the central role of the S-protein in the pathogenesis of C. fetus infection. The S-protein is not toxic per se, but enhances virulence when present on the bacterial cell surface as a capsule. JF - The Journal of clinical investigation AU - Pei, Z AU - Blaser, M J AD - Medical Service, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 1036 EP - 1043 VL - 85 IS - 4 SN - 0021-9738, 0021-9738 KW - Bacterial Proteins KW - 0 KW - Lipopolysaccharides KW - Iron KW - E1UOL152H7 KW - Abridged Index Medicus KW - Index Medicus KW - Virulence KW - Animals KW - Sepsis -- prevention & control KW - Mice, Inbred ICR KW - Mice, Inbred C3H KW - Lethal Dose 50 KW - Lipopolysaccharides -- toxicity KW - Mice KW - Species Specificity KW - Iron -- metabolism KW - Female KW - Bacterial Proteins -- toxicity KW - Campylobacter fetus -- pathogenicity KW - Bacterial Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79694911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Pathogenesis+of+Campylobacter+fetus+infections.+Role+of+surface+array+proteins+in+virulence+in+a+mouse+model.&rft.au=Pei%2C+Z%3BBlaser%2C+M+J&rft.aulast=Pei&rft.aufirst=Z&rft.date=1990-04-01&rft.volume=85&rft.issue=4&rft.spage=1036&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-09 N1 - Date created - 1990-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1988 May;81(5):1434-44 [3366901] J Immunol. 1978 Feb;120(2):422-4 [202651] Anal Biochem. 1978 Jun 15;87(1):206-10 [98070] Am J Med. 1978 Oct;65(4):584-92 [707518] Infect Immun. 1978 Nov;22(2):560-7 [365761] Anal Biochem. 1980 Jul 1;105(2):361-3 [6161559] Annu Rev Biochem. 1981;50:715-31 [6455965] N Engl J Med. 1981 Dec 10;305(24):1444-52 [7029281] Infect Immun. 1983 Feb;39(2):908-16 [6832823] Infect Immun. 1985 Feb;47(2):353-9 [3967920] J Infect Dis. 1985 Feb;151(2):227-35 [3968449] Arch Intern Med. 1985 Feb;145(2):289-92 [3977489] J Immunol. 1985 May;134(5):2820-3 [3884708] Infect Immun. 1986 Jan;51(1):209-12 [3510169] JAMA. 1986 Jan 17;255(3):361-4 [3753617] J Clin Microbiol. 1986 Mar;23(3):431-3 [2937803] J Infect Dis. 1987 Apr;155(4):696-706 [3819475] J Biol Chem. 1988 May 5;263(13):6416-20 [3360785] Microbiol Rev. 1978 Mar;42(1):45-66 [379572] Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 [388439] J Immunol. 1980 Jan;124(1):20-4 [6985638] Nature. 1968 Sep 21;219(5160):1253-4 [4877918] J Bacteriol. 1969 Oct;100(1):64-70 [4899010] Am J Epidemiol. 1970 Apr;91(4):400-9 [5421893] J Infect Dis. 1971 Oct;124(4):401-10 [4947218] J Bacteriol. 1972 Sep;111(3):731-8 [4559824] Curr Top Microbiol Immunol. 1973;60:1-30 [4197776] J Biol Chem. 1974 Jan 25;249(2):634-44 [4129205] Science. 1974 May 31;184(4140):952-6 [4596821] J Exp Med. 1974 Nov 1;140(5):1147-61 [4138849] Infect Immun. 1975 Mar;11(3):517-25 [46843] J Med Microbiol. 1975 Nov;8(4):477-90 [812996] Infect Immun. 1976 Feb;13(2):457-63 [1262061] Infect Immun. 1976 Mar;13(3):722-7 [773822] Can J Microbiol. 1976 Jun;22(6):832-8 [819118] Infect Immun. 1976 Apr;13(4):1258-65 [819374] Infect Immun. 1976 Sep;14(3):626-30 [965087] Infect Immun. 1977 Jan;15(1):26-33 [319060] J Immunol. 1977 Jul;119(1):162-6 [326955] Acta Vet Acad Sci Hung. 1976;26(3):257-62 [829758] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of interstrain renal transplantation on NaCl-induced hypertension in Dahl rats. AN - 79694129; 2318525 AB - Previous studies using renal transplantation suggested that the genotype of a homograft kidney plays the primary role in determining chronic arterial pressure levels in Dahl salt-sensitive (DS) and salt-resistant (DR) rats, but this conclusion derived largely from observations during low NaCl diet. Recent studies indicate that extrarenal factors, including the sympathetic nervous system, play a critical role in the development of NaCl-induced hypertension in DS rats. To assess the contribution of extrarenal and renal factors in the development of NaCl-induced hypertension in Dahl rats, we performed renal transplantation in DS and DR rats. Both kidneys of the recipient were removed at the time of transplantation. Four groups of rats (n = 18-23 in each group) were fed a high NaCl (8.0%) diet for 2 weeks after renal transplantation. These included DRR, DRS, DSR, and DSS, where DR or DS indicates the recipient strain and the subscript indicates the homograft strain. Mean arterial pressure was measured from the femoral artery in conscious rats. On a high NaCl diet, mean arterial pressure was significantly lower (p less than 0.05) in DRR (103 +/- 2 mm Hg; mean +/- SEM) compared with DRS (145 +/- 5 mm Hg), DSR (151 +/- 7 mm Hg), and DSS (160 +/- 5 mm Hg). The finding that DR rats with a DS kidney (DRS) developed hypertension during high NaCl diet confirms the concept that the kidney plays an important hypertensinogenic role in the Dahl strain. The fact that DS rats with a DR kidney (DSR) also developed hypertension indicates that extrarenal factors also contribute significantly to NaCl-induced hypertension in DS rats. JF - Hypertension (Dallas, Tex. : 1979) AU - Morgan, D A AU - DiBona, G F AU - Mark, A L AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 436 EP - 442 VL - 15 IS - 4 SN - 0194-911X, 0194-911X KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Diet, Sodium-Restricted KW - Kidney -- pathology KW - Nephrectomy -- methods KW - Drug Resistance KW - Female KW - Kidney Transplantation -- mortality KW - Hypertension -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79694129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Effects+of+interstrain+renal+transplantation+on+NaCl-induced+hypertension+in+Dahl+rats.&rft.au=Morgan%2C+D+A%3BDiBona%2C+G+F%3BMark%2C+A+L&rft.aulast=Morgan&rft.aufirst=D&rft.date=1990-04-01&rft.volume=15&rft.issue=4&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-09 N1 - Date created - 1990-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study. AN - 79692394; 2318517 AB - We compared the efficacy and adverse effects of antihypertensive drug regimens in 690 men past age 60 with diastolic blood pressure 90-114 mm Hg and systolic blood pressure less than 240 mm Hg. They received either a low (25-50 mg) or high (50-100 mg) dose of hydrochlorothiazide daily. Of 644 patients who completed the hydrochlorothiazide titration, 375 (58.2%) were responders (diastolic blood pressure less than 90 and less than or equal to 5 mm Hg below baseline) and 92.8% of these completed a 6-month maintenance period. Blood pressure was reduced from 157.6/98.5 mm Hg by 18.3/9.5 mm Hg with low dose hydrochlorothiazide and by 20.4/9.6 mm Hg with high dose hydrochlorothiazide; more patients achieved goal blood pressure with the high dose. Whites and blacks responded equally. Serum potassium less than 3.5 mmol/l occurred in 104 of 321 (32.3%) of the high dose versus 62 of 333 (18.6%) of the low dose hydrochlorothiazide patients. The 269 nonresponders to hydrochlorothiazide were randomly assigned in a double-blind study to receive hydralazine, methyldopa, metoprolol, or reserpine in addition to hydrochlorothiazide; 79.2% responded to the addition of the second drug and 87.3% of these completed a 6-month maintenance phase. Overall, there were no significant efficacy differences among the step 2 regimens. We conclude that the lower dose of hydrochlorothiazide was nearly as effective as the higher dose, and the addition of a second drug was effective and generally well tolerated in elderly patients. JF - Hypertension (Dallas, Tex. : 1979) AU - Materson, B J AU - Cushman, W C AU - Goldstein, G AU - Reda, D J AU - Freis, E D AU - Ramirez, E A AU - Talmers, F N AU - White, T J AU - Nunn, S AU - Chapman, R H AD - Department of Veterans Affairs, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 348 EP - 360 VL - 15 IS - 4 SN - 0194-911X, 0194-911X KW - Antihypertensive Agents KW - 0 KW - Diuretics KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Osmolar Concentration KW - Drug Administration Schedule KW - Humans KW - Continental Population Groups KW - Aged KW - Aging -- physiology KW - Drug Therapy, Combination KW - Heart Rate KW - Hydrochlorothiazide -- administration & dosage KW - Diuretics -- therapeutic use KW - Potassium -- blood KW - Middle Aged KW - Blood Pressure -- drug effects KW - Hydrochlorothiazide -- therapeutic use KW - Male KW - Hydrochlorothiazide -- adverse effects KW - Hypertension -- physiopathology KW - Hypertension -- blood KW - Antihypertensive Agents -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79692394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Treatment+of+hypertension+in+the+elderly%3A+I.+Blood+pressure+and+clinical+changes.+Results+of+a+Department+of+Veterans+Affairs+Cooperative+Study.&rft.au=Materson%2C+B+J%3BCushman%2C+W+C%3BGoldstein%2C+G%3BReda%2C+D+J%3BFreis%2C+E+D%3BRamirez%2C+E+A%3BTalmers%2C+F+N%3BWhite%2C+T+J%3BNunn%2C+S%3BChapman%2C+R+H&rft.aulast=Materson&rft.aufirst=B&rft.date=1990-04-01&rft.volume=15&rft.issue=4&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-09 N1 - Date created - 1990-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. AN - 79686620; 1969357 AB - Amino acid concentrations were measured in specific structures from the brains of rats decapitated before and during the course of status epilepticus induced by lithium and pilocarpine, with the stages of status defined by the electroencephalographic (EEG) pattern displayed. Early status was marked by discrete seizures on EEG, mid status by continuous spiking, and late status by periodic epileptiform discharges. Aspartate levels were lower than control levels in most regions prior to the onset of status. The decline continued and reached statistical significance in different regions at times from early to late status. Glutamate concentrations were typically higher than control just prior to status onset and then decreased in a manner similar to aspartate, but with less percentage change. gamma-Aminobutyric acid increased during status, with the earliest statistically significant differences observed in mid status. These changes were observed in most forebrain structures studied, but the largest percentage changes in excitatory amino acid concentration were found in substantia nigra, where they fell to less than half of control. JF - Experimental neurology AU - Walton, N Y AU - Gunawan, S AU - Treiman, D M AD - Neurology Service, Veterans Administration West Los Angeles Medical Center, California. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 61 EP - 70 VL - 108 IS - 1 SN - 0014-4886, 0014-4886 KW - Amino Acids KW - 0 KW - Glutamates KW - Pilocarpine KW - 01MI4Q9DI3 KW - Glutamine KW - 0RH81L854J KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Aspartic Acid -- metabolism KW - Animals KW - Glutamine -- metabolism KW - Glutamates -- metabolism KW - Electroencephalography KW - gamma-Aminobutyric Acid -- metabolism KW - Tissue Distribution KW - Male KW - Status Epilepticus -- chemically induced KW - Status Epilepticus -- metabolism KW - Brain -- metabolism KW - Amino Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79686620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Brain+amino+acid+concentration+changes+during+status+epilepticus+induced+by+lithium+and+pilocarpine.&rft.au=Walton%2C+N+Y%3BGunawan%2C+S%3BTreiman%2C+D+M&rft.aulast=Walton&rft.aufirst=N&rft.date=1990-04-01&rft.volume=108&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-10 N1 - Date created - 1990-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethanol and the pancreas. Current status. AN - 79665839; 2179029 JF - Gastroenterology AU - Singh, M AU - Simsek, H AD - Pancreatic Research Laboratory, Veterans Administration Medical Center, Augusta, Georgia. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 1051 EP - 1062 VL - 98 IS - 4 SN - 0016-5085, 0016-5085 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Humans KW - Chronic Disease KW - Ethanol -- toxicity KW - Pancreatitis -- etiology KW - Pancreas -- drug effects KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79665839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Ethanol+and+the+pancreas.+Current+status.&rft.au=Singh%2C+M%3BSimsek%2C+H&rft.aulast=Singh&rft.aufirst=M&rft.date=1990-04-01&rft.volume=98&rft.issue=4&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 1990 Nov;99(5):1544-6 [2210270] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Additive effects of ileal secretagogues in the rat. AN - 79660016; 2107113 AB - Although clinical diarrhea is often caused by more than one enteropathogen, it is not known whether secretagogues have additive effects on secretion. This question was examined in anesthetized, ventilated rats by exposing the ileum to secretory agents with different mechanisms of action. Four hours after inoculation of ileal loops with either cholera toxin or saline, transport was measured during perfusion with Ringer's solution, with Ringer's solution containing Escherichia coli heat-stable enterotoxin or mannitol, or with Ringer's solution containing both heat-stable enterotoxin and mannitol. We found that heat-stable enterotoxin caused similar decrements in water absorption in loops exposed to Ringer's solution, hypertonic mannitol, cholera toxin, and cholera toxin plus mannitol. By contrast, the decrement in water transport caused by hypertonic mannitol was inversely related to the level of ongoing water transport. In addition, the electrolyte transport changes caused by each enterotoxin were preserved despite the presence of other secretory agents. These data suggest that the transport effects of secretagogues with different mechanisms of action are additive in the ileum. However, the absolute decrements in water absorption may be independent of (heat-stable enterotoxin and cholera toxin) or dependent on (hypertonic mannitol) the ongoing level of water transport. JF - Gastroenterology AU - Charney, A N AU - Dansky, H M AD - Nephrology Section, Veterans Administration Medical Center, New York, New York. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 881 EP - 887 VL - 98 IS - 4 SN - 0016-5085, 0016-5085 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Escherichia coli Proteins KW - Isotonic Solutions KW - heat stable toxin (E coli) KW - Mannitol KW - 3OWL53L36A KW - Ringer's solution KW - 8026-10-6 KW - Cholera Toxin KW - 9012-63-9 KW - Abridged Index Medicus KW - Index Medicus KW - Stimulation, Chemical KW - Rats, Inbred Strains KW - Rats KW - Intestinal Secretions -- drug effects KW - Animals KW - Isotonic Solutions -- pharmacology KW - Male KW - Ileum -- secretion KW - Cholera Toxin -- pharmacology KW - Water-Electrolyte Balance -- drug effects KW - Enterotoxins -- pharmacology KW - Bacterial Toxins -- pharmacology KW - Diarrhea -- etiology KW - Mannitol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79660016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Additive+effects+of+ileal+secretagogues+in+the+rat.&rft.au=Charney%2C+A+N%3BDansky%2C+H+M&rft.aulast=Charney&rft.aufirst=A&rft.date=1990-04-01&rft.volume=98&rft.issue=4&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Living Systems Approach to Understanding the Concept of Stress AN - 61054949; 90X1007 AB - Responding to the need for a general, interdisciplinary conceptual framework for stress, the basic concepts of living systems theory are summarized. Stress, strain, exertion, & distress are defined, & three stages of stress are identified. Mechanisms by which a system may be resistant to stress are described, with examples from biology & the social sciences. Stress-related pathology resulting from exhaustion or maladjustment is explained, & a stress pathway depicted. Such an interdisciplinary framework should allow for more rigorous formulation & testing of hypotheses about stress, leading to better treatment of stress-related disorders. 1 Figure, 15 References. Modified AA JF - Behavioral Science AU - Steinberg, Alan AU - Ritzmann, Ron F AD - Psychiatry Service Sepulveda Veterans Administration Medical Center, 16111 Plummer St CA 91343 Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 138 EP - 146 VL - 35 IS - 2 SN - 0005-7940, 0005-7940 KW - stress, interdisciplinary conceptual framework KW - Psychological Stress KW - Methodology (Philosophical) KW - Theoretical Problems KW - Interdisciplinary Approach KW - article KW - 0103: methodology and research technology; methodology (conceptual & epistemological) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61054949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Science&rft.atitle=A+Living+Systems+Approach+to+Understanding+the+Concept+of+Stress&rft.au=Steinberg%2C+Alan%3BRitzmann%2C+Ron+F&rft.aulast=Steinberg&rft.aufirst=Alan&rft.date=1990-04-01&rft.volume=35&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Behavioral+Science&rft.issn=00057940&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - BEHSAS N1 - SubjectsTermNotLitGenreText - Psychological Stress; Theoretical Problems; Methodology (Philosophical); Interdisciplinary Approach ER - TY - JOUR T1 - An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy. AN - 79651492; 2407872 AB - This multicenter, factorial-design trial assessed the safety and additive antihypertensive efficacy of a slow-release (SR) formulation of diltiazem hydrochloride given alone or in combination with hydrochlorothiazide for treatment of mild to moderate hypertension. After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 possible combinations of diltiazem SR and hydrochlorothiazide for 6 weeks. A dose-related reduction in blood pressure was demonstrated for each drug as monotherapy and for the two drugs in combination. Absolute blood pressures of patients who received combination therapy were lower by an overall mean of 3.0 mm Hg diastolic and 8.0 mm Hg systolic vs diltiazem SR used alone and 3.5 mm Hg diastolic and 4.0 mm Hg systolic vs hydrochlorothiazide used alone. At the largest doses used, 50% of patients achieved goal blood pressure while taking hydrochlorothiazide, 57% while taking diltiazem SR, and 75% while taking combination therapy. Combination therapy was well tolerated. This trial clearly demonstrates that diltiazem SR and hydrochlorothiazide have additive antihypertensive effects. JF - JAMA AU - Burris, J F AU - Weir, M R AU - Oparil, S AU - Weber, M AU - Cady, W J AU - Stewart, W H AD - Hypertension Research Unit, Veterans Administration Medical Center, Washington, DC. Y1 - 1990/03/16/ PY - 1990 DA - 1990 Mar 16 SP - 1507 EP - 1512 VL - 263 IS - 11 SN - 0098-7484, 0098-7484 KW - Delayed-Action Preparations KW - 0 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Diltiazem KW - EE92BBP03H KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Analysis of Variance KW - Double-Blind Method KW - Logistic Models KW - Humans KW - Adult KW - Middle Aged KW - Research Design KW - Male KW - Female KW - Hydrochlorothiazide -- administration & dosage KW - Diltiazem -- administration & dosage KW - Diltiazem -- therapeutic use KW - Hypertension -- drug therapy KW - Hydrochlorothiazide -- adverse effects KW - Diltiazem -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79651492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=An+assessment+of+diltiazem+and+hydrochlorothiazide+in+hypertension.+Application+of+factorial+trial+design+to+a+multicenter+clinical+trial+of+combination+therapy.&rft.au=Burris%2C+J+F%3BWeir%2C+M+R%3BOparil%2C+S%3BWeber%2C+M%3BCady%2C+W+J%3BStewart%2C+W+H&rft.aulast=Burris&rft.aufirst=J&rft.date=1990-03-16&rft.volume=263&rft.issue=11&rft.spage=1507&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-03 N1 - Date created - 1990-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1990 Aug 22-29;264(8):971-3 [2248649] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Failure of Trypanosoma cruzi to trigger the respiratory burst of activated macrophages. Mechanism for immune evasion and importance of oxygen-independent killing. AN - 79671763; 2155965 AB - Activated macrophages are thought to kill Trypanosoma cruzi, which lack catalase, by the generation of hydrogen peroxide. We investigated triggering of the respiratory burst of activated macrophages induced by phagocytosis of virulent T. cruzi, bloodform trypomastigotes, amastigotes obtained from spleens, and tissue culture organisms; and of relatively nonvirulent epimastigotes. All stages of T. cruzi prompted the release of less than 10% of hydrogen peroxide released by activated macrophages when stimulated with PMA or Candida. Superoxide anion production was not stimulated by PMA or Candida in activated macrophages nor was there a significant qualitative reduction of nitroblue tetrazolium induced by ingestion of virulent T. cruzi. Opsonization of T. cruzi with specific antibody did not promote the release of hydrogen peroxide or the reduction of nitroblue tetrazolium. Similar results were observed with activated spleen macrophages. Incubation of activated macrophages with catalase, catalase and superoxide dismutase, sodium benzoate with or without catalase, and respiratory burst-exhausting PMA failed to inhibit the killing of T. cruzi in vitro. These results indicate that 1) virulent opsonized or unopsonized T. cruzi do not trigger a respiratory burst by activated macrophages and 2) oxygen-independent killing of T. cruzi is of prime importance. JF - Journal of immunology (Baltimore, Md. : 1950) AU - McCabe, R E AU - Mullins, B T AD - Department of Medicine, Martinez Veterans Administration Medical Center, CA 94553. Y1 - 1990/03/15/ PY - 1990 DA - 1990 Mar 15 SP - 2384 EP - 2388 VL - 144 IS - 6 SN - 0022-1767, 0022-1767 KW - Antigen-Antibody Complex KW - 0 KW - Benzoates KW - Superoxides KW - 11062-77-4 KW - Benzoic Acid KW - 8SKN0B0MIM KW - Hydrogen Peroxide KW - BBX060AN9V KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hydrogen Peroxide -- metabolism KW - Macrophage Activation KW - Mice KW - Benzoates -- pharmacology KW - Catalase -- pharmacology KW - Oxidation-Reduction KW - Superoxides -- metabolism KW - Peritoneal Cavity -- cytology KW - Superoxide Dismutase -- pharmacology KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Phagocytosis KW - Trypanosoma cruzi -- growth & development KW - Macrophages -- immunology KW - Trypanosoma cruzi -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79671763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Failure+of+Trypanosoma+cruzi+to+trigger+the+respiratory+burst+of+activated+macrophages.+Mechanism+for+immune+evasion+and+importance+of+oxygen-independent+killing.&rft.au=McCabe%2C+R+E%3BMullins%2C+B+T&rft.aulast=McCabe&rft.aufirst=R&rft.date=1990-03-15&rft.volume=144&rft.issue=6&rft.spage=2384&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-16 N1 - Date created - 1990-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determination of the therapeutic index of floxuridine by its circadian infusion pattern. AN - 79619568; 2137540 AB - To test if circadian timing of a drug is important for its toxicity and antitumor activity, we compared the circadian patterns observed with seven equal doses of floxuridine (FUDR) infused either at a variable rate or at a constant rate in female F344 rats. For the variable-rate infusion, the daily dose of FUDR was divided into four 6-hour portions of 68%, 15%, 2%, and 15% to achieve a quasisinusoidal pattern. Peak drug delivery occurred during one of six different times of day. At a dose level resulting in 50% overall mortality, lethal toxicity differed significantly, depending on the circadian stage of maximum drug delivery. Depending on the circadian stage of maximum drug flow, variable-rate infusions were more toxic than or as toxic as constant-rate infusion. FUDR lethality was lowest when constant-rate infusion was used or when variable-rate infusion peaked during the late activity-early rest span of the recipients. The circadian pattern of variable-rate infusion also determined the antitumor activity in tumor-bearing rats. At a therapeutic dose level and at identical dose intensity, the variable-rate-infusion pattern, with peak drug flow during the late activity-early rest span, resulted in significantly greater delay in tumor growth than was observed with either the constant-rate infusion or other variable-rate patterns. We conclude that the toxicity and antitumor activity of FUDR depend on the circadian timing of the infusion peak when the drug is given by variable-rate infusion. Since some of the circadian-shaped infusions studied are toxicologically and therapeutically inferior to constant-rate infusion, the circadian pattern and not the quasi-intermittency of circadian FUDR administration is primarily responsible for these pharmacodynamic differences. JF - Journal of the National Cancer Institute AU - von Roemeling, R AU - Hrushesky, W J AD - Department of Internal Medicine, Albany Veterans Administration Medical Center, Albany Medical College of Union University, NY 12208. Y1 - 1990/03/07/ PY - 1990 DA - 1990 Mar 07 SP - 386 EP - 393 VL - 82 IS - 5 SN - 0027-8874, 0027-8874 KW - Floxuridine KW - 039LU44I5M KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Random Allocation KW - Neoplasm Transplantation KW - Rats KW - Rats, Inbred F344 KW - Infusion Pumps KW - Circadian Rhythm KW - Adenocarcinoma -- secondary KW - Data Interpretation, Statistical KW - Adenocarcinoma -- drug therapy KW - Female KW - Floxuridine -- administration & dosage KW - Floxuridine -- therapeutic use KW - Floxuridine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79619568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Determination+of+the+therapeutic+index+of+floxuridine+by+its+circadian+infusion+pattern.&rft.au=von+Roemeling%2C+R%3BHrushesky%2C+W+J&rft.aulast=von+Roemeling&rft.aufirst=R&rft.date=1990-03-07&rft.volume=82&rft.issue=5&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increasing group attendance on a psychiatric unit: an alternating treatments design comparison. AN - 79894953; 2373766 AB - Compliance is a critical factor for success in the treatment of chronic psychiatric patients. Major reasons for therapeutic failure are that patients discontinue their medications, fail to keep therapist appointments, or do not participate in recommended psychosocial activities. An alternating treatments design was employed to assess the use of verbal instructions and feedback to promote group attendance on a psychiatric unit. Results showed these methods served to significantly increase group attendance but had no significant effect on patient satisfaction. These results are discussed with regard to cost-efficient methods for promoting treatment compliance with psychiatric inpatients. JF - Journal of behavior therapy and experimental psychiatry AU - Blake, D D AU - Owens, M D AU - Keane, T M AD - Boston Veterans Administration Medical Center, MA 02130. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 15 EP - 20 VL - 21 IS - 1 SN - 0005-7916, 0005-7916 KW - Index Medicus KW - Personality Disorders -- therapy KW - Humans KW - Anxiety Disorders -- therapy KW - Adult KW - Mood Disorders -- therapy KW - Consumer Behavior KW - Aged KW - Middle Aged KW - Substance-Related Disorders -- rehabilitation KW - Schizophrenia -- therapy KW - Male KW - Female KW - Therapeutic Community KW - Mental Disorders -- therapy KW - Patient Compliance KW - Psychotherapy, Group -- methods KW - Behavior Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79894953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+behavior+therapy+and+experimental+psychiatry&rft.atitle=Increasing+group+attendance+on+a+psychiatric+unit%3A+an+alternating+treatments+design+comparison.&rft.au=Blake%2C+D+D%3BOwens%2C+M+D%3BKeane%2C+T+M&rft.aulast=Blake&rft.aufirst=D&rft.date=1990-03-01&rft.volume=21&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+behavior+therapy+and+experimental+psychiatry&rft.issn=00057916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-27 N1 - Date created - 1990-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Legionella infection in transplant patients. AN - 79785461; 2188318 AB - Since the discovery of Legionella pneumophila in the late 1970s, this organism and other Legionella sp have been an important cause of pneumonia in solid organ transplant recipients. Legionella sp are obligate aerobes that require a source of amino acids, iron, and L-cystine. Growth is enhanced in a 5% CO2 atmosphere at 37 degrees C in the presence of charcoal. Legionella sp reside in water supplies and hospital outbreaks associated with contaminated water have been described. Transplant recipients are particularly susceptible to Legionella infection. Legionella pneumonia tends to occur within several weeks after transplantation and frequently coincides with episodes of rejection. A prodrome of influenza-like symptoms is followed by a sometimes "explosive" pneumonia with patchy lobular or interstitial infiltrates on chest radiograph. High fever, abdominal pain, and mental status changes are sometimes seen. Diagnosis is made by examination of respiratory secretions by the direct fluorescent antibody technique or culture of the organism. Intravenous erythromycin is the treatment of choice. Rifampin is added if there is a lack of response. Both erythromycin and rifampin have important and opposite effects on cyclosporine metabolism, which may result, respectively, in increased cyclosporine toxicity or graft loss. Patients who must continue cyclosporine will, therefore, require frequent monitoring of cyclosporine levels. JF - Seminars in respiratory infections AU - Ampel, N M AU - Wing, E J AD - Arizona Health Sciences Center, Veterans Administration Medical Center, Tucson. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 30 EP - 37 VL - 5 IS - 1 SN - 0882-0546, 0882-0546 KW - Index Medicus KW - Bronchoscopy KW - Legionella -- isolation & purification KW - Risk Factors KW - Humans KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Immune Tolerance KW - Transplantation -- adverse effects KW - Legionnaires' Disease -- microbiology KW - Legionnaires' Disease -- epidemiology KW - Legionnaires' Disease -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79785461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+infections&rft.atitle=Legionella+infection+in+transplant+patients.&rft.au=Ampel%2C+N+M%3BWing%2C+E+J&rft.aulast=Ampel&rft.aufirst=N&rft.date=1990-03-01&rft.volume=5&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+infections&rft.issn=08820546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk management for extrapyramidal symptoms. AN - 79783361; 1971435 AB - Extrapyramidal symptoms (EPS), the side effects of antipsychotic medications, have become the focus of much attention from clinical researchers, the courts, consumer groups, and even the U.S. Congress. The major clinical manifestations of EPS, the etiology, symptoms, and treatments are reviewed. The literature identified risk factors for EPS--those specific to the patient, to the particular antipsychotic agent used, and to the nature of the ongoing treatment for EPS. By quantifying these factors, weighting them according to the known risks, a risk management tool is developed for use in predicting which patients are at higher risks for EPS, in evaluating treatment, and in assessing the responses of patients to changes in their condition and to the subsequent adjustments in treatment. The risk management tool provides guidelines for the continual evaluation of these changes, with the goal of minimizing the risks for EPS. JF - QRB. Quality review bulletin AU - Blair, D T AD - Extended Care Psychiatry, Veterans Administration Medical Center, Topeka, Kansas. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 116 EP - 124 VL - 16 IS - 3 SN - 0097-5990, 0097-5990 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Risk Management -- methods KW - Basal Ganglia Diseases -- prevention & control KW - Basal Ganglia Diseases -- nursing KW - Antipsychotic Agents -- adverse effects KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79783361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=QRB.+Quality+review+bulletin&rft.atitle=Risk+management+for+extrapyramidal+symptoms.&rft.au=Blair%2C+D+T&rft.aulast=Blair&rft.aufirst=D&rft.date=1990-03-01&rft.volume=16&rft.issue=3&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=QRB.+Quality+review+bulletin&rft.issn=00975990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-27 N1 - Date created - 1990-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: QRB Qual Rev Bull. 1990 Jul;16(7):270 [1977115] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tracheal insufflation of tumor necrosis factor protects rats against oxygen toxicity. AN - 79778914; 2341345 AB - Tracheal insufflation of tumor necrosis factor (TNF; 5 micrograms or 1.2 x 10(5) U) markedly enhanced the survival of adult rats exposed to 100% O2: 12 of 17 rats (71%) survived for greater than 11 days, whereas 30 of 30 control (Hanks' balanced salt solution) insufflated rats (100%) died within 3 days of O2 exposure. Insufflation of gamma-interferon (5 micrograms) or intraperitoneal injection of up to 40 micrograms TNF did not afford any protection. At 55 h after O2 exposure, TNF-insufflated rats showed less pulmonary edema, as determined by the extravascular lung water content-to-bloodless lung dry weigh ratio and less alveolar capillary leak as determined by the protein content in the bronchoalveolar lavage fluid, than control insufflated rats similarly exposed. This protection against O2 toxicity by TNF insufflation was associated with increased lung superoxide dismutase, catalase, and glutathione peroxidase activities. The enhancement of lung antioxidant enzyme activities was noted at 55 h of O2 exposure, when control animals began to die of O2 toxicity. This temporal relationship suggests that TNF-induced increase in antioxidant enzyme activities contributes, at least in part, to the observed protection. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Tsan, M F AU - White, J E AU - Santana, T A AU - Lee, C Y AD - Research Service, Veterans Administration Medical Center, Albany, New York. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 1211 EP - 1219 VL - 68 IS - 3 SN - 8750-7587, 8750-7587 KW - Proteins KW - 0 KW - Tumor Necrosis Factor-alpha KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Catalase -- metabolism KW - Animals KW - Neutrophils -- pathology KW - Glutathione Peroxidase -- metabolism KW - In Vitro Techniques KW - Superoxide Dismutase -- metabolism KW - Trachea KW - Proteins -- metabolism KW - Male KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Oxygen -- pharmacology KW - Lung -- drug effects KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79778914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Tracheal+insufflation+of+tumor+necrosis+factor+protects+rats+against+oxygen+toxicity.&rft.au=Tsan%2C+M+F%3BWhite%2C+J+E%3BSantana%2C+T+A%3BLee%2C+C+Y&rft.aulast=Tsan&rft.aufirst=M&rft.date=1990-03-01&rft.volume=68&rft.issue=3&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A twelve-year clinical and immunologic evaluation of workers involved in the manufacture of trimellitic anhydride (TMA). AN - 79764335; 2338240 AB - The spectrum of immunologic lung disease occurring in a population of 196 workers involved in the manufacture of trimellitic anhydride (TMA) was assessed from January 1976 through December 1987. Workers were evaluated clinically by history, blood counts and chemistries, chest x-ray, and pulmonary function studies. Immunologic tests included skin testing with trimellityl-human serum albumin (TM-HSA) and assay of total antibody (TA) and of IgE antibody binding of 125I-TM-HSA. Seventeen workers had IgE-mediated asthma/rhinitis with a positive prick test to TM-HSA and IgE antibody of 0.8-57 ng of TM-HSA bound/ml. Seven workers had a late respiratory systemic syndrome with TA from 760-56,000 ng of TM-HSA bound/ml. Four had both syndromes. Three had late onset asthma with TA of 3,700-10,000 and trace levels of IgE to TM-HSA. One had marked arthralgia and myalgia occurring hours after TMA exposure, without respiratory symptoms, with an elevated TA level of 24,000. Of 46 workers reporting no symptoms, 8% had low TA levels, while 16% of 113 with irritant symptoms had low TA levels. There was a reduction in the number of workers exhibiting an immunologic syndrome during 1982-1987-8% (7 of 85) compared to 23% (26 of 111) during 1976-1981--in spite of increased TMA production. This paralleled environmental control and worker education efforts. Cooperative research by an academic Allergy-Immunology program and industry has defined TMA clinical syndromes and provided methods of immunologic monitoring, resulting in a reduction in new cases in spite of increased production of TMA. JF - Allergy proceedings : the official journal of regional and state allergy societies AU - Zeiss, C R AU - Mitchell, J H AU - Van Peenen, P F AU - Harris, J AU - Levitz, D AD - Veterans Administration Lakeside Medical Center, Chicago, IL. PY - 1990 SP - 71 EP - 77 VL - 11 IS - 2 SN - 1046-9354, 1046-9354 KW - Phthalic Acids KW - 0 KW - Phthalic Anhydrides KW - Immunoglobulin E KW - 37341-29-0 KW - trimellitic anhydride KW - 80T61EUU7H KW - Index Medicus KW - Asthma -- etiology KW - Rhinitis -- etiology KW - Rhinitis -- immunology KW - Humans KW - Hypersensitivity, Delayed -- immunology KW - Immunoglobulin E -- immunology KW - Hypersensitivity, Delayed -- etiology KW - Immunoglobulin E -- analysis KW - Syndrome KW - Adult KW - Middle Aged KW - Environmental Monitoring -- methods KW - Female KW - Male KW - Asthma -- immunology KW - Phthalic Acids -- adverse effects KW - Lung Diseases -- etiology KW - Occupational Diseases -- immunology KW - Occupational Diseases -- etiology KW - Phthalic Anhydrides -- adverse effects KW - Lung Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79764335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Allergy+proceedings+%3A+the+official+journal+of+regional+and+state+allergy+societies&rft.atitle=A+twelve-year+clinical+and+immunologic+evaluation+of+workers+involved+in+the+manufacture+of+trimellitic+anhydride+%28TMA%29.&rft.au=Zeiss%2C+C+R%3BMitchell%2C+J+H%3BVan+Peenen%2C+P+F%3BHarris%2C+J%3BLevitz%2C+D&rft.aulast=Zeiss&rft.aufirst=C&rft.date=1990-03-01&rft.volume=11&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Allergy+proceedings+%3A+the+official+journal+of+regional+and+state+allergy+societies&rft.issn=10469354&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-21 N1 - Date created - 1990-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Digital amputations in neuropathic feet. AN - 79745376; 2159069 AB - A retrospective study was performed on 26 patients who had undergone 27 digital amputations. All of the patients in the study had marked neuropathy. Sixty-five percent of the feet developed new ulcerations following initial hallux amputations, with 53% of the ulcerations occurring at distal digital sites. Fifty-three percent of the patients who had undergone hallux amputations required further amputations secondary to new ulcerations. In contrast, only 10% of the feet with initial lesser digit amputations developed new ulcerations. The authors discuss the biomechanics involved and the possible therapy for preventing these ulcerations and amputations. JF - Journal of the American Podiatric Medical Association AU - Greteman, B AU - Dale, S AD - Department of Podiatric Surgery, Veterans Administration Medical Center, Montain Home, TN. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 120 EP - 126 VL - 80 IS - 3 SN - 8750-7315, 8750-7315 KW - Index Medicus KW - Postoperative Complications KW - Amputation KW - Humans KW - Peripheral Nervous System Diseases -- surgery KW - Toes -- surgery KW - Foot Diseases -- etiology KW - Diabetic Neuropathies -- surgery KW - Hallux -- surgery KW - Ulcer -- etiology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79745376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Podiatric+Medical+Association&rft.atitle=Digital+amputations+in+neuropathic+feet.&rft.au=Greteman%2C+B%3BDale%2C+S&rft.aulast=Greteman&rft.aufirst=B&rft.date=1990-03-01&rft.volume=80&rft.issue=3&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Podiatric+Medical+Association&rft.issn=87507315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-05 N1 - Date created - 1990-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Am Podiatr Med Assoc 1990 May;80(5):253 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse antibiotic effects associated with renal insufficiency. AN - 79743369; 2184494 AB - We review the English-language literature on antibiotic-associated adverse reactions in patients with renal insufficiency in order to highlight this important but often overlooked clinical problem. Because many adverse reactions to antibiotics are not dependent on renal function, we have attempted to review only those reactions that are believed to be associated with renal insufficiency or that have been reported in patients with impaired renal function. Adverse effects of antibiotics in this setting can be divided into six major categories: neurologic toxicity, coagulopathy, nephrotoxicity, hypoglycemia, hematologic toxicity, and aminoglycoside inactivation by penicillins. Neurologic toxicity can be further divided into central nervous system toxicity consisting primarily of encephalopathy and seizures, ototoxicity, peripheral neuropathy, and neuromuscular blockade/respiratory depression. We explore the factors in uremia that may contribute to the susceptibility of patients with renal insufficiency to the adverse effects of antibiotics. Moreover, we make general recommendations regarding the use of the discussed antibiotics in patients with compromised renal function. JF - Reviews of infectious diseases AU - Manian, F A AU - Stone, W J AU - Alford, R H AD - Division of Infectious Diseases, Nashville Veterans Administration Medical Center, Tennessee. PY - 1990 SP - 236 EP - 249 VL - 12 IS - 2 SN - 0162-0886, 0162-0886 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Penicillins KW - Index Medicus KW - Blood Coagulation Disorders -- chemically induced KW - Bone Marrow Diseases -- chemically induced KW - Humans KW - Middle Aged KW - Penicillins -- adverse effects KW - Nervous System Diseases -- chemically induced KW - Hypoglycemia -- chemically induced KW - Male KW - Kidney Diseases -- chemically induced KW - Kidney Failure, Chronic -- metabolism KW - Anti-Bacterial Agents -- adverse effects KW - Anti-Bacterial Agents -- antagonists & inhibitors KW - Anti-Bacterial Agents -- pharmacokinetics KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79743369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Adverse+antibiotic+effects+associated+with+renal+insufficiency.&rft.au=Manian%2C+F+A%3BStone%2C+W+J%3BAlford%2C+R+H&rft.aulast=Manian&rft.aufirst=F&rft.date=1990-03-01&rft.volume=12&rft.issue=2&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-29 N1 - Date created - 1990-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Rev Infect Dis. 1991 Jul-Aug;13(4):772-3 [1925303] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spontaneous, nontraumatic gangrene due to Clostridium septicum. AN - 79739477; 2330482 AB - Clostridium septicum is a major cause of spontaneous, nontraumatic gas gangrene. Unlike Clostridium perfringens, C. septicum is relatively aerotolerant and thus appears to be more capable of initiating infection in the absence of obvious damage to tissues. Six cases illustrate the clinical setting and fulminant nature of spontaneous gangrene caused by C. septicum. A lesion in the colon such as carcinoma is often present and is presumed to serve as a portal of entry to the bloodstream. Diabetes and leukopenia are also common predisposing conditions; compromise of vital host responses may facilitate proliferation of those organisms that settle out in the tissues. Acute lymphoma or leukemia during a course of chemotherapy is accompanied by damage to bowel mucosa and granulocytopenia, thus predisposing to spontaneous clostridial gangrene. Infection progresses in a fulminating manner; the majority of patients die within 24 hours of onset. Characteristic symptoms and signs include excruciating pain (although a sense of heaviness may be the only early symptom), swelling of tissues, crepitance, and bulla formation. A hallmark of C. septicum infection is the absence of acute inflammatory cells in involved tissues or in bulla fluid. A series of laboratory investigations demonstrated that fluid obtained from a bulla adversely affected the viability, morphology, and function of polymorphonuclear leukocytes (PMNs), which may explain the paucity of PMNs in involved tissues and may in part contribute to the fulminant progression observed in infection due to this organism. JF - Reviews of infectious diseases AU - Stevens, D L AU - Musher, D M AU - Watson, D A AU - Eddy, H AU - Hamill, R J AU - Gyorkey, F AU - Rosen, H AU - Mader, J AD - Infectious Disease Sections, Veterans Administration Medical Centers, Boise, Idaho. PY - 1990 SP - 286 EP - 296 VL - 12 IS - 2 SN - 0162-0886, 0162-0886 KW - Index Medicus KW - Adenocarcinoma -- complications KW - Colonic Neoplasms -- complications KW - Aged, 80 and over KW - Humans KW - Diabetes Mellitus, Type 2 -- complications KW - Aged KW - Middle Aged KW - Male KW - Female KW - Cardiomyopathy, Alcoholic -- complications KW - Gas Gangrene -- microbiology KW - Clostridium -- isolation & purification KW - Gas Gangrene -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79739477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Spontaneous%2C+nontraumatic+gangrene+due+to+Clostridium+septicum.&rft.au=Stevens%2C+D+L%3BMusher%2C+D+M%3BWatson%2C+D+A%3BEddy%2C+H%3BHamill%2C+R+J%3BGyorkey%2C+F%3BRosen%2C+H%3BMader%2C+J&rft.aulast=Stevens&rft.aufirst=D&rft.date=1990-03-01&rft.volume=12&rft.issue=2&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-29 N1 - Date created - 1990-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. AN - 79739126; 2331235 AB - Rats were tested for choice accuracy in an eight-arm radial maze during and after chronic administration of nicotine via subcutaneously implanted glass and Silastic capsules. Nicotine administration significantly improved choice accuracy relative to controls. The effect gradually became apparent over the first 2 weeks of exposure and persisted through the third week. Surprisingly, the significant facilitation of the nicotine-treated rats relative to controls continued for 2 weeks after the end of nicotine administration. No effects of nicotine were seen on choice latency or the strategy to make adjacent arm entries. JF - Behavioral and neural biology AU - Levin, E D AU - Lee, C AU - Rose, J E AU - Reyes, A AU - Ellison, G AU - Jarvik, M AU - Gritz, E AD - Nicotine Research Laboratory, Veterans Administration Medical Center, Durham, North Carolina 27705. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 269 EP - 276 VL - 53 IS - 2 SN - 0163-1047, 0163-1047 KW - Drug Implants KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Choice Behavior -- drug effects KW - Attention -- drug effects KW - Mental Recall -- drug effects KW - Male KW - Discrimination Learning -- drug effects KW - Nicotine -- pharmacology KW - Orientation -- drug effects KW - Substance Withdrawal Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79739126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+neural+biology&rft.atitle=Chronic+nicotine+and+withdrawal+effects+on+radial-arm+maze+performance+in+rats.&rft.au=Levin%2C+E+D%3BLee%2C+C%3BRose%2C+J+E%3BReyes%2C+A%3BEllison%2C+G%3BJarvik%2C+M%3BGritz%2C+E&rft.aulast=Levin&rft.aufirst=E&rft.date=1990-03-01&rft.volume=53&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+neural+biology&rft.issn=01631047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-31 N1 - Date created - 1990-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Efficacy of ACC-9653 (a phenytoin prodrug) in experimental status epilepticus in the rat. AN - 79728340; 2328717 AB - Status epilepticus was induced by injection of homocysteine thiolactone to rats with epileptogenic cortical cobalt lesions. Either standard phenytoin or ACC-9653 (a phenytoin prodrug) was injected after the second generalized tonic-clonic seizure. Rats treated with ACC-9653 had significantly poorer treatment outcomes than rats treated with standard phenytoin, although no differences were found in the concentration of phenytoin in plasma or brain 65 min after injection. JF - Epilepsy research AU - Walton, N Y AU - Treiman, D M AD - Neurology and Research Services, West Los Angeles Veterans Administration Medical Center, CA. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 165 EP - 168 VL - 5 IS - 2 SN - 0920-1211, 0920-1211 KW - Prodrugs KW - 0 KW - Phenytoin KW - 6158TKW0C5 KW - fosphenytoin KW - B4SF212641 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Male KW - Status Epilepticus -- chemically induced KW - Phenytoin -- pharmacokinetics KW - Phenytoin -- analogs & derivatives KW - Prodrugs -- therapeutic use KW - Phenytoin -- therapeutic use KW - Status Epilepticus -- physiopathology KW - Status Epilepticus -- drug therapy KW - Prodrugs -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79728340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=Efficacy+of+ACC-9653+%28a+phenytoin+prodrug%29+in+experimental+status+epilepticus+in+the+rat.&rft.au=Walton%2C+N+Y%3BTreiman%2C+D+M&rft.aulast=Walton&rft.aufirst=N&rft.date=1990-03-01&rft.volume=5&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-30 N1 - Date created - 1990-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validity of the MCMI Drug Abuse Scale with drug abusing and psychiatric samples. AN - 79714252; 2324309 AB - The validity of the Drug Abuse Scale (T) from the Millon Clinical Multiaxial Inventory (MCMI) was studied by administering the MCMI to 75 White male veterans who were seeking treatment for opioid or cocaine dependence and 60 White male veterans without diagnoses of drug dependence who were receiving psychiatric care. Only (39.4%) of the drug-abusing sample was classified correctly by obtaining base rate (BR) scores above the clinical relevant cut-off of 74, whereas, only 12% of the psychiatric sample was misclassified by having obtained a BR above 74. The results suggest that the MCMI T Scale is limited in its ability to identify drug users, but is also unlikely to misclassify psychiatric patients as drug abusers when they are not. The authors urge caution in using the Drug Abuse Scale for the purpose of identifying drug abusers. JF - Journal of clinical psychology AU - Calsyn, D A AU - Saxon, A J AU - Daisy, F AD - Veterans Administration Medical Center, Seattle, WA. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 244 EP - 246 VL - 46 IS - 2 SN - 0021-9762, 0021-9762 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Adult KW - Middle Aged KW - Psychometrics KW - Male KW - Opioid-Related Disorders -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Opioid-Related Disorders -- psychology KW - Personality Inventory KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79714252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Validity+of+the+MCMI+Drug+Abuse+Scale+with+drug+abusing+and+psychiatric+samples.&rft.au=Calsyn%2C+D+A%3BSaxon%2C+A+J%3BDaisy%2C+F&rft.aulast=Calsyn&rft.aufirst=D&rft.date=1990-03-01&rft.volume=46&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-24 N1 - Date created - 1990-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chlorpromazine-induced immunopathy: progressive increase in serum IgM. AN - 79698622; 2319941 AB - Long-term chlorpromazine therapy has been associated with the asymptomatic development of a high incidence of antinuclear antibodies, coagulation inhibitors, and increased serum levels of IgM. The purpose of this study has been to characterize the natural history of this chlorpromazine-induced (CPZ) immunopathy. To this end we carried out a prospective study of schizophrenic patients with the immunopathy to compare the effect of continuing CPZ versus switching to haloperidol therapy. Although no marked differences were noted between the 2 groups at the end of 5 years, 6 of 29 patients who continued to receive CPZ, as compared to none of 14 patients on haloperidol, had progressive elevations of serum IgM. In spite of a high incidence of antinuclear antibodies, none of the patients developed a lupus-like syndrome. One patient, however, who had been maintained on CPZ for more than 15 years, developed Waldenström macroglobulinemia, as characterized by an IgM monoclonal gammopathy and a lymphocyte immunoglobulin heavy and kappa light chain gene rearrangement. Another CPZ-treated patient developed immune thrombocytopenia. Based on the potential serious sequelae of prolonged stimulation of the immune system by CPZ, we recommend that patients who develop an increase in serum IgM while on CPZ be switched to other types of anti-psychotic medications. JF - Medicine AU - Zucker, S AU - Zarrabi, H M AU - Schubach, W H AU - Varma, A AU - Derman, R AU - Lysik, R M AU - Habicht, G AU - Seitz, P M AD - Department of Medicine, Veterans Administration Medical Center, Northport, NY 11768. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 92 EP - 100 VL - 69 IS - 2 SN - 0025-7974, 0025-7974 KW - Antibodies, Antinuclear KW - 0 KW - Immunoglobulin M KW - Chlorpromazine KW - U42B7VYA4P KW - Abridged Index Medicus KW - Index Medicus KW - Lymphocyte Activation KW - Prospective Studies KW - Gene Rearrangement -- drug effects KW - Humans KW - Genes, Immunoglobulin KW - Middle Aged KW - Antibodies, Antinuclear -- analysis KW - Male KW - Immunoglobulin M -- analysis KW - Chlorpromazine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79698622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine&rft.atitle=Chlorpromazine-induced+immunopathy%3A+progressive+increase+in+serum+IgM.&rft.au=Zucker%2C+S%3BZarrabi%2C+H+M%3BSchubach%2C+W+H%3BVarma%2C+A%3BDerman%2C+R%3BLysik%2C+R+M%3BHabicht%2C+G%3BSeitz%2C+P+M&rft.aulast=Zucker&rft.aufirst=S&rft.date=1990-03-01&rft.volume=69&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Medicine&rft.issn=00257974&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-02 N1 - Date created - 1990-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intracerebroventricular infusion of RU28318 blocks aldosterone-salt hypertension. AN - 79683339; 2316642 AB - The chronic intracerebroventricular (icv) infusion of aldosterone in rats and dogs elevates the blood pressure within 10-14 days at doses far below those that produce hypertension systemically. The effect in rats is dose dependent and blocked by the concomitant icv infusion of the antimineralocorticoid, prorenone. The effect of the icv infusion of RU28318, another specific spironolactone mineralocorticoid antagonist, on the hypertension produced by chronic subcutaneous (sc) administration of aldosterone in sensitized rats was reported. Miniosmotic pumps were used to deliver 1 micrograms/h aldosterone sc and 1.1 micrograms/h RU8318 icv. Over a 24-day period the indirect systolic blood pressure of the control, RU28318 icv, and aldosterone sc plus RU28318 icv groups increased from 105 to 123 mmHg and were not significantly different from each other, whereas the aldosterone sc group increased to 156 mmHg. RU28318, icv or sc, did not alter the increase in urine volume produced by aldosterone sc, and there was no significant differences in weight between the groups. This study provides evidence of the importance of the central nervous system in the pathogenesis of hypertension produced by systemic mineralocorticoid excess. JF - The American journal of physiology AU - Gómez-Sánchez, E P AU - Fort, C M AU - Gómez-Sánchez, C E AD - Research Service, J.A. Haley Veterans Administration Hospital, Tampa, Florida 33612. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - E482 EP - E484 VL - 258 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Mineralocorticoid Receptor Antagonists KW - 0 KW - Sodium, Dietary KW - Spironolactone KW - 27O7W4T232 KW - Aldosterone KW - 4964P6T9RB KW - RU 28318 KW - 76676-34-1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Blood Pressure -- drug effects KW - Infusions, Parenteral KW - Male KW - Spironolactone -- pharmacology KW - Spironolactone -- analogs & derivatives KW - Hypertension -- chemically induced KW - Sodium, Dietary -- pharmacology KW - Hypertension -- prevention & control KW - Cerebral Ventricles -- physiology KW - Mineralocorticoid Receptor Antagonists -- pharmacology KW - Aldosterone -- pharmacology KW - Cerebral Ventricles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79683339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Intracerebroventricular+infusion+of+RU28318+blocks+aldosterone-salt+hypertension.&rft.au=G%C3%B3mez-S%C3%A1nchez%2C+E+P%3BFort%2C+C+M%3BG%C3%B3mez-S%C3%A1nchez%2C+C+E&rft.aulast=G%C3%B3mez-S%C3%A1nchez&rft.aufirst=E&rft.date=1990-03-01&rft.volume=258&rft.issue=3+Pt+1&rft.spage=E482&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo determination of valproate binding constants during sole and multi-drug therapy. AN - 79682205; 2107606 AB - Valproate (VPA) is present in humans and is largely bound to protein. Only free drug is metabolized, and antiepileptic and toxic effects are probably related to free concentrations. By measuring serial free and total serum VPA levels after routine oral doses, we have determined individual in vivo protein binding parameters for 37 patients after a total of 49 separate drug administrations. Binding site concentrations and dissociation constants were fitted using a nonlinear algorithm. On sole VPA (n = 28) the mean dissociation constant was 91 mumol/L, and the mean concentration of binding sites was 1,176 mumol/L. Evidence suggests a second, nonsaturable binding site. Fraction of unbound VPA ranged from 5.4% at low levels up to 38.7%, rising with increasing total concentration. Concurrent therapy with phenytoin (n = 7) or carbamazepine (n = 8) did not cause displacement of VPA. Changes in free fraction were consistently observed during the interdose interval. The data demonstrate that the binding changes are not a factor in decreased VPA levels during coadministration of other antiepileptic drugs. JF - Therapeutic drug monitoring AU - Scheyer, R D AU - Cramer, J A AU - Toftness, B R AU - Hochholzer, J M AU - Mattson, R H AD - Epilepsy Center, Veterans Administration Medical Center, West Haven, Connecticut 06516. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 117 EP - 123 VL - 12 IS - 2 SN - 0163-4356, 0163-4356 KW - Carbamazepine KW - 33CM23913M KW - Valproic Acid KW - 614OI1Z5WI KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Drug Therapy, Combination KW - Phenytoin -- metabolism KW - Phenytoin -- therapeutic use KW - Humans KW - Food KW - Binding, Competitive KW - Carbamazepine -- administration & dosage KW - Seizures -- drug therapy KW - Carbamazepine -- therapeutic use KW - Carbamazepine -- metabolism KW - Phenytoin -- administration & dosage KW - Valproic Acid -- metabolism KW - Valproic Acid -- therapeutic use KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79682205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=In+vivo+determination+of+valproate+binding+constants+during+sole+and+multi-drug+therapy.&rft.au=Scheyer%2C+R+D%3BCramer%2C+J+A%3BToftness%2C+B+R%3BHochholzer%2C+J+M%3BMattson%2C+R+H&rft.aulast=Scheyer&rft.aufirst=R&rft.date=1990-03-01&rft.volume=12&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=01634356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-25 N1 - Date created - 1990-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. AN - 79657613; 2155276 AB - The effects of pentoxifylline (Trental) on human neutrophil CR3 up-modulation, degranulation, and superoxide production were studied. We used the chemotactic peptide fMLP and the phorbol ester PMA as soluble stimuli, and beta-glucan particles as a CR3-specific solid phase stimulus of neutrophil superoxide production. Since neutrophils have adenosine A2 receptors, we compared effects of pentoxifylline to effects of adenosine, and we also looked at the effect of cytochalasin B, which breaks up actin filaments. Pentoxifylline inhibited both CR3 up-modulation and degranulation of myeloperoxidase and lysozyme. Pentoxifylline is a more potent inhibitor of fMLP- compared to PMA-induced degranulation, and is especially potent against superoxide production. While pentoxifylline is less potent than adenosine in its inhibition of fMLP-induced superoxide production, it is more potent in its inhibition of PMA- and beta-glucan particle-stimulated superoxide production. Cytochalasin B, which enhances degranulation and fMLP-stimulated superoxide production, was found to inhibit beta-glucan particle-stimulated superoxide production. These findings are consistent with the hypothesis that pentoxifylline can affect both the cytoskeletal architecture of unstimulated neutrophils and the activation and responses of neutrophils which involve actin polymerization and receptor-cytoskeletal interactions. JF - Journal of leukocyte biology AU - Currie, M S AU - Rao, K M AU - Padmanabhan, J AU - Jones, A AU - Crawford, J AU - Cohen, H J AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Durham, North Carolina 27705. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 244 EP - 250 VL - 47 IS - 3 SN - 0741-5400, 0741-5400 KW - Glucans KW - 0 KW - Receptors, Complement KW - Receptors, Complement 3b KW - Superoxides KW - 11062-77-4 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Adenosine KW - K72T3FS567 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Theobromine KW - OBD445WZ5P KW - Pentoxifylline KW - SD6QCT3TSU KW - Index Medicus KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Glucans -- pharmacology KW - Adenosine -- pharmacology KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cytoskeleton -- physiology KW - Neutrophils -- drug effects KW - Superoxides -- metabolism KW - Pentoxifylline -- pharmacology KW - Receptors, Complement -- analysis KW - Neutrophils -- immunology KW - Neutrophils -- physiology KW - Theobromine -- analogs & derivatives KW - Cell Degranulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79657613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Stimulus-specific+effects+of+pentoxifylline+on+neutrophil+CR3+expression%2C+degranulation%2C+and+superoxide+production.&rft.au=Currie%2C+M+S%3BRao%2C+K+M%3BPadmanabhan%2C+J%3BJones%2C+A%3BCrawford%2C+J%3BCohen%2C+H+J&rft.aulast=Currie&rft.aufirst=M&rft.date=1990-03-01&rft.volume=47&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-03 N1 - Date created - 1990-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - EEG sleep studies in "pure" primary alcoholism during subacute withdrawal: relationships to normal controls, age, and other clinical variables. AN - 79656448; 2310803 AB - Electroencephalogram (EEG) sleep recordings were compared in 34 normal controls and 31 inpatients with relatively pure primary alcoholism who had been abstinent for about 17 days. Compared with normal controls, primary alcoholics took longer to fall asleep, slept less, and had poor sleep efficiency. Sleep loss reflected reduced non-rapid eye movement (NREM) sleep, especially stage 2 sleep, stage 4 sleep, and total delta (stage 3 and 4) sleep. Alcoholic patients had higher REM density of the first REM period. Sleep deteriorated with age in both normal controls and patients, with younger alcoholics showing sleep patterns typical of older controls. Among other clinical-demographic variables examined, the shorter the duration of sobriety at the time of the study, the later patients went to bed and fell asleep. The number of drinks per drinking day in the 3 months before admission was directly related to the duration of the first REM period. In addition, the maximum number of withdrawal symptoms the patient had ever experienced was inversely related to the amount of delta sleep. Sleep measures were not correlated with depression rating, liver enzymes, or other measures of alcohol consumption. JF - Biological psychiatry AU - Gillin, J C AU - Smith, T L AU - Irwin, M AU - Kripke, D F AU - Schuckit, M AD - San Diego Veterans Administration Medical Center, CA. Y1 - 1990/03/01/ PY - 1990 DA - 1990 Mar 01 SP - 477 EP - 488 VL - 27 IS - 5 SN - 0006-3223, 0006-3223 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Liver Diseases, Alcoholic -- rehabilitation KW - Reaction Time -- drug effects KW - Sleep, REM -- drug effects KW - Depressive Disorder -- psychology KW - Humans KW - Adult KW - Middle Aged KW - Delta Rhythm KW - Liver Function Tests KW - Male KW - Alcoholism -- rehabilitation KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- rehabilitation KW - Electroencephalography -- drug effects KW - Substance Withdrawal Syndrome -- psychology KW - Sleep Stages -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79656448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=EEG+sleep+studies+in+%22pure%22+primary+alcoholism+during+subacute+withdrawal%3A+relationships+to+normal+controls%2C+age%2C+and+other+clinical+variables.&rft.au=Gillin%2C+J+C%3BSmith%2C+T+L%3BIrwin%2C+M%3BKripke%2C+D+F%3BSchuckit%2C+M&rft.aulast=Gillin&rft.aufirst=J&rft.date=1990-03-01&rft.volume=27&rft.issue=5&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-20 N1 - Date created - 1990-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. AN - 79649856; 2307514 AB - Helicobacter pylori infection is strongly associated with histologic gastritis and peptic ulcer disease. Broth culture supernatants from a subset of H. pylori strains induce vacuolization in cultured cells, a phenomenon that has been attributed to cytotoxin activity. Concentrated culture supernatants from 15 of 28 (53.6%) H. pylori strains tested induced vacuolization in HeLa cells in titers ranging from 1:10 to 1:180. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and silver staining of supernatants from these 28 strains and 2 control strains demonstrated an 82-kilodalton (kDa) protein band in 3 of 16 supernatants with vacuolizing activity, but in none of 14 supernatants without vacuolizing activity. By immunoblotting with human sera, a 128-kDa band was recognized in all 16 supernatants with vacuolizing activity, compared with 9 of 14 (64%) supernatants without vacuolizing activity (P = 0.014). Serologic recognition of the 128-kDa band in H. pylori culture supernatants was more prevalent among persons infected with vacuolizing H. pylori strains than among persons infected with nonvacuolizing strains, but the difference was not statistically significant (80 versus 45%; P = 0.079); human serologic recognition of the 82-kDa band was less common. The 128-kDa band was recognized by 100% of 31 serum samples from H. pylori-infected patients with duodenal ulcer disease, compared with 60.8% of 74 serum samples from H. pylori-infected persons without peptic ulcer disease (P = 0.0001). These data indicate that antigenic 128- and 82-kDa proteins are present in H. pylori broth culture supernatants with vacuolizing activity and that serologic responses to the 128-kDa protein are more prevalent among H. pylori-infected persons with duodenal ulceration than among infected persons without peptic ulceration. JF - Infection and immunity AU - Cover, T L AU - Dooley, C P AU - Blaser, M J AD - Infectious Disease Section, Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 603 EP - 610 VL - 58 IS - 3 SN - 0019-9567, 0019-9567 KW - Antibodies, Bacterial KW - 0 KW - Bacterial Proteins KW - Cytotoxins KW - Immunoglobulin G KW - Pronase KW - EC 3.4.24.- KW - Index Medicus KW - Animals KW - Vacuoles -- drug effects KW - Stomach -- pathology KW - Immunoglobulin G -- analysis KW - Antibodies, Bacterial -- analysis KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Rabbits KW - Pronase -- pharmacology KW - Peptic Ulcer -- etiology KW - Female KW - Campylobacter -- pathogenicity KW - Bacterial Proteins -- immunology KW - Cytotoxins -- immunology KW - Bacterial Proteins -- analysis KW - Cytotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79649856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Characterization+of+and+human+serologic+response+to+proteins+in+Helicobacter+pylori+broth+culture+supernatants+with+vacuolizing+cytotoxin+activity.&rft.au=Cover%2C+T+L%3BDooley%2C+C+P%3BBlaser%2C+M+J&rft.aulast=Cover&rft.aufirst=T&rft.date=1990-03-01&rft.volume=58&rft.issue=3&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-30 N1 - Date created - 1990-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1983 Oct;42(1):276-84 [6618667] Annu Rev Med. 1989;40:269-85 [2658752] Med J Aust. 1985 Apr 15;142(8):439-44 [3982346] Infect Immun. 1985 May;48(2):528-33 [2580793] J Clin Microbiol. 1985 Dec;22(6):1007-10 [4066910] J Infect Dis. 1986 Apr;153(4):664-9 [3950448] Ultrastruct Pathol. 1986;10(2):113-22 [3961927] J Clin Pathol. 1986 Apr;39(4):353-65 [3517070] Am J Clin Pathol. 1986 Nov;86(5):575-82 [2430450] Gut. 1986 Oct;27(10):1132-7 [3781324] Am J Gastroenterol. 1987 Apr;82(4):297-301 [2436471] Infect Immun. 1987 May;55(5):1256-63 [3552997] Gastroenterology. 1987 Aug;93(2):371-83 [3297911] Gastroenterology. 1988 Jan;94(1):33-40 [3335295] Arch Intern Med. 1988 May;148(5):1149-51 [3365082] Ann Intern Med. 1988 Jul 1;109(1):11-7 [3288028] J Clin Microbiol. 1988 May;26(5):831-6 [3384908] J Med Microbiol. 1988 Jun;26(2):93-9 [3385767] Scand J Gastroenterol. 1988 Jun;23(5):585-90 [3399831] Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):576-8 [3141176] Am J Clin Pathol. 1988 Dec;90(6):711-4 [3195501] J Clin Microbiol. 1989 Jan;27(1):225-6 [2913034] Infect Immun. 1989 Apr;57(4):1119-25 [2925243] Anal Biochem. 1984 Jan;136(1):175-9 [6424501] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the transferrin receptor in UMR-106-01 osteoblast-like cells. AN - 79644656; 2307125 AB - The accumulation of iron or aluminum can cause metabolic bone disease, but the mechanisms by which these agents affect bone metabolism remain uncertain. Since transferrin (Tf) can bind several different metals in plasma, equilibrium radioligand binding studies were performed to identify and characterize the Tf receptor in UMR-106-01 osteoblast-like cells; the role of Tf as a modifier of metal-induced changes in cell proliferation was also examined. Osteoblast-like cells grown in serum-free medium have approximately 40,000 Tf receptors on the cell membrane. Tf receptor expression increases during iron depletion and decreases with iron supplementation; the number of Tf receptors was also inversely related to both cell density and the rate of cell proliferation in vitro. Physiological levels of unsaturated Tf (5 microM) enhanced DNA synthesis in osteoblast-like cells maintained in serum-free medium, as measured by the incorporation of tritiated thymidine into DNA. Although neither 10 microM iron (Fe) nor 10 microM gallium (Ga), a known antiproliferative agent, altered DNA synthesis in UMR-106-01 cells during 48-h incubations in serum-free medium, both agents reduced the rate of DNA synthesis when added to serum-free medium containing 5 microM apo-Tf. Decreases in the incorporation of [3H] thymidine into DNA were also noted in osteoblast-like cells incubated for 48 h with 3 microM partially saturated iron Tf or gallium Tf. The results indicate that osteoblast-like cells have a single class of membrane receptors for Tf and that the regulation of Tf receptor expression in UMR-106-01 cells is similar to that in other cell types. The uptake of iron and gallium via the Tf-receptor complex can affect osteoblast proliferation, and such a mechanism may contribute to the bone cell toxicity of various metals. JF - Endocrinology AU - Kasai, K AU - Hori, M T AU - Goodman, W G AD - Medical Service, Veterans Administration Medical Center, Sepulveda, California 91343. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 1742 EP - 1749 VL - 126 IS - 3 SN - 0013-7227, 0013-7227 KW - Acetates KW - 0 KW - Apoproteins KW - Receptors, Transferrin KW - Transferrin KW - apotransferrin KW - DNA KW - 9007-49-2 KW - Gallium KW - CH46OC8YV4 KW - Iron KW - E1UOL152H7 KW - Acetic Acid KW - Q40Q9N063P KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Count KW - Iron -- pharmacology KW - Cell Division -- drug effects KW - Transferrin -- pharmacology KW - Radioligand Assay KW - DNA -- biosynthesis KW - Iron -- metabolism KW - Acetates -- pharmacology KW - Biological Availability KW - Transferrin -- metabolism KW - Thymidine -- metabolism KW - Gallium -- pharmacology KW - Tumor Cells, Cultured KW - Binding, Competitive KW - Apoproteins -- metabolism KW - Osteoblasts -- metabolism KW - Receptors, Transferrin -- metabolism KW - Osteoblasts -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79644656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Characterization+of+the+transferrin+receptor+in+UMR-106-01+osteoblast-like+cells.&rft.au=Kasai%2C+K%3BHori%2C+M+T%3BGoodman%2C+W+G&rft.aulast=Kasai&rft.aufirst=K&rft.date=1990-03-01&rft.volume=126&rft.issue=3&rft.spage=1742&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-05 N1 - Date created - 1990-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs. AN - 79644450; 2137727 AB - Intracoronary infusions of activated complement C5a result in myocardial ischemia, contractile dysfunction, and leukocyte accumulation. The hypothesis was tested that the generation of the coronary vasoconstrictors, thromboxane A2 and the 5-lipoxygenase leukotrienes (LTC4 and LTD4), contributes to the C5a-induced decrease in coronary blood flow and contractile function. The left anterior descending coronary artery in anesthetized swine was cannulated and servo pump-perfused with arterial blood at constant pressure and measured flow. Regional subendocardial contractile function was assessed with sonomicrometry. The interventricular vein was cannulated for sampling of coronary venous blood for leukocyte count. The responses in left anterior descending coronary artery blood flow and percent segment shortening to intracoronary infusions of LTC4 (1 microgram), LTD4 (1 microgram), thromboxane agonist U46619 (7.5 micrograms), and C5a (500 ng) were assessed before and after 1) LTD4/LTE4 receptor blockade with leukotriene receptor blocker LY171883 (10 mg/kg i.v.) (n = 5), 2) thromboxane A2/prostaglandin H2 receptor blockade with thromboxane receptor blocker BM13505 (2 mg/kg i.v.) (n = 5), and 3) combined thromboxane and leukotriene receptor blockade (n = 5). In the absence of receptor blockade, intracoronary C5a decreased coronary flow (50-60%) and regional segment function (60-70%) compared with the preinfusion levels. This was accompanied by a fall in coronary venous blood leukocyte levels by 5-6 x 10(6) cells/ml in the absence of alterations in arterial blood leukocyte count. Intracoronary injections of LTD4, LTC4, or U46619 also resulted in prompt decreases in coronary blood flow (50-60%) and segment function (70-80%) from preinfusion levels. Leukotriene receptor blockade with LY171883 abolished these responses to LTD4 and LTC4. Administration of LY171883 also attenuated (p less than 0.05) the myocardial response to C5a; coronary flow and segment function decreased by approximately 28% from preinfusion levels. Thromboxane receptor blockade with BM13505 eliminated the response in coronary flow and segment function to intracoronary U46619. Similar to LY171883, administration of BM13505 blunted (p less than 0.05) the C5a-induced decreases in coronary flow and contractile function, which fell by approximately 20-25% from the preinfusion level. After the combined LTD4/LTE4 receptor and thromboxane A2/prostaglandin H2 receptor blockade, intracoronary C5a resulted in little change in both coronary blood flow and segment shortening. In contrast to the flow and function effects, the C5a-induced myocardial leukocyte extraction was not decreased by leukotriene and/or thromboxane receptor blockade.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Circulation research AU - Ito, B R AU - Roth, D M AU - Engler, R L AD - Department of Medicine, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 596 EP - 607 VL - 66 IS - 3 SN - 0009-7330, 0009-7330 KW - Leukotrienes KW - 0 KW - Receptors, Immunologic KW - Receptors, Prostaglandin KW - Receptors, Thromboxane KW - SRS-A KW - Thromboxanes KW - Thromboxane A2 KW - 57576-52-0 KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Swine KW - Animals KW - Coronary Vessels KW - Injections, Intra-Arterial KW - Receptors, Immunologic -- physiology KW - Coronary Circulation -- drug effects KW - Leukotrienes -- metabolism KW - Thromboxanes -- metabolism KW - Receptors, Prostaglandin -- physiology KW - Time Factors KW - Female KW - Male KW - Coronary Disease -- chemically induced KW - SRS-A -- analogs & derivatives KW - Myocardial Contraction -- drug effects KW - Thromboxane A2 -- physiology KW - SRS-A -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79644450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Thromboxane+A2+and+peptidoleukotrienes+contribute+to+the+myocardial+ischemia+and+contractile+dysfunction+in+response+to+intracoronary+infusion+of+complement+C5a+in+pigs.&rft.au=Ito%2C+B+R%3BRoth%2C+D+M%3BEngler%2C+R+L&rft.aulast=Ito&rft.aufirst=B&rft.date=1990-03-01&rft.volume=66&rft.issue=3&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-06 N1 - Date created - 1990-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An Unusual Case of Capgras Syndrome: The Psychiatric Ward as a Stage AN - 61230635; 91X6233 AB - An analysis of a case of Capgras syndrome -- which involves the delusion that certain people have been replaced by imposters -- from a biopsychological approach. An unusual case of a 31-year-old male with a multifaceted misidentification delusion involving the entire staff & patients of a psychiatric unit, except for the patient himself, is presented. It is observed that the appearance & reinforcement of the patient's delusional thinking are consequences of an interplay of psychological, organic, ecological factors, relating to a long-term environmental exposure that provided him with the sociocultural surroundings to shape the content of his delusions. This case illuminates the value of a biopsychological perspective for understanding Capgras & other misidentification delusions. 16 References. I. Shagrir JF - Psychiatric Journal of the University of Ottawa/Revue de Psychiatrie de l'Universite d'Ottawa AU - Silva, J Arturo AU - Leong, Gregory B AU - O'Reilly, Tara AD - Psychiatry Service (B116A11) Veterans Administration Medical Center, 11301 Wilshire Blvd Los Angeles CA 90073 Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 44 EP - 46 VL - 15 IS - 1 KW - Capgras syndrome/other misidentification delusions, biopsychological approach KW - case example KW - Biological Factors KW - Psychosis KW - Mental Illness KW - Mental Hospitals KW - article KW - 0373: social psychology; cognitive/interpretive sociologies, symbolic interactionism & ethnomethodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61230635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Journal+of+the+University+of+Ottawa%2FRevue+de+Psychiatrie+de+l%27Universite+d%27Ottawa&rft.atitle=An+Unusual+Case+of+Capgras+Syndrome%3A+The+Psychiatric+Ward+as+a+Stage&rft.au=Silva%2C+J+Arturo%3BLeong%2C+Gregory+B%3BO%27Reilly%2C+Tara&rft.aulast=Silva&rft.aufirst=J&rft.date=1990-03-01&rft.volume=15&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Journal+of+the+University+of+Ottawa%2FRevue+de+Psychiatrie+de+l%27Universite+d%27Ottawa&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PJUODZ N1 - SubjectsTermNotLitGenreText - Mental Hospitals; Biological Factors; Mental Illness; Psychosis ER - TY - JOUR T1 - Labeling the Child of an Alcoholic: Negative Stereotyping by Mental Health Professionals and Peers AN - 61042518; 90X0982 AB - The effects of labeling a child of an alcoholic (COA) on the perceptions of peers & mental health professionals are examined using questionnaire data from 570 high school students in a small midwestern US city & 80 health professionals, each of whom rated teenagers with or without alcoholic parent(s) & with or without other impairments in a series of vignettes. Results indicate that typical teenagers were rated in a positive manner, while COAs & mentally ill teenagers were rated negatively. COAs were rated as significantly different from typical teenagers & mentally ill teenagers. Teenagers portrayed as having an alcoholic father were judged more pathological than those portrayed as not having an alcoholic father, regardless of behavior. Consequences of the COA label are discussed. 2 Tables, 26 References. D. Generoli JF - Journal of Studies on Alcohol AU - Burk, Jeffrey P AU - Sher, Kenneth J AD - Veterans Administration Medical Center, 4500 South Lancaster Rd Dallas TX 75216 Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 156 EP - 163 VL - 51 IS - 2 SN - 0096-882X, 0096-882X KW - child of alcoholic label, mental health professionals'/peers' perceptions KW - questionnaires, vignettes KW - US KW - Health Professions KW - Labeling KW - Alcoholism KW - United States of America KW - Peer Relations KW - Mental Health KW - Parents KW - High School Students KW - Adolescents KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61042518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Labeling+the+Child+of+an+Alcoholic%3A+Negative+Stereotyping+by+Mental+Health+Professionals+and+Peers&rft.au=Burk%2C+Jeffrey+P%3BSher%2C+Kenneth+J&rft.aulast=Burk&rft.aufirst=Jeffrey&rft.date=1990-03-01&rft.volume=51&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Alcoholism; Labeling; Mental Health; Health Professions; Peer Relations; High School Students; United States of America; Parents; Adolescents ER - TY - JOUR T1 - Strength and Duration of Word-Completion Priming as a Function of Word Repetition and Spacing AN - 58210668; 9005049 AB - The effects of stimulus repetition & spacing on strength & duration of word-completion priming were evaluated in a study in which Ss (N = 48 adults) studied words that were presented 4, 16, or 32 times & then took tests of word-stem completion & recognition memory. No long-lasting word-completion effects were found. Four or more repetitions produced a stronger priming effect than one or two repetitions. However, larger numbers of repetitions did not appear to have a significant facilitative effect on performance either 2 or 24 hours after presentation. It is concluded that word-completion effects based on presentation of single words are inherently short term. 1 Table, 2 Figures, 28 References. B. Annesser Murray JF - The Bulletin of the Psychonomic Society AU - Chen, Karen S AU - Squire, Larry R AD - c/o Squire-Veterans Administration Medical Center V116A, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 97 EP - 100 VL - 28 IS - 2 SN - 0090-5054, 0090-5054 KW - word repetition strength/duration, stimulus repetition/spacing effects KW - adults KW - Word Recognition and Discrimination (wo5) KW - Psycholinguistics (ps3) KW - Memory (me3) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58210668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Bulletin+of+the+Psychonomic+Society&rft.atitle=Strength+and+Duration+of+Word-Completion+Priming+as+a+Function+of+Word+Repetition+and+Spacing&rft.au=Chen%2C+Karen+S%3BSquire%2C+Larry+R&rft.aulast=Chen&rft.aufirst=Karen&rft.date=1990-03-01&rft.volume=28&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=The+Bulletin+of+the+Psychonomic+Society&rft.issn=00905054&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BPNSBY N1 - SubjectsTermNotLitGenreText - Word Recognition and Discrimination (wo5); Memory (me3); Psycholinguistics (ps3) ER - TY - JOUR T1 - The Effects of Right Hemisphere Damage on the Pragmatic Interpretation of Conversational Remarks AN - 85508952; 9007263 AB - The ability of right-hemisphere-damaged (RHD) patients to interpret a speaker's intended or pragmatic meaning in context was evaluated. The interpretation of utterances having veridical & nonveridical sentence meanings was explored. It was hypothesized that the RHD patients would be sensitive to the literal truth of such utterances, but would have difficulty with integrating information about the quality of an actor's performance with information about the speaker-actor relationship. Thus, RHD patients might have difficulty distinguishing between nonveridical meanings such as sarcasm & "white lies" occurring where the speaker had motivation to be kind. Stimulus vignettes (48) involving an actor & a speaker involved in everyday activities that included a positive or negative comment by the speaker & qualification of the actor's performance of a particular activity as "very good" or "very bad" were presented to RHD patients (N = 12 males). Ss answered questions about the factual content of the vignette & about the speaker's pragmatic intent & the effect of the utterance on the actor. The patients were able to give pragmatically appropriate interpretations of some exchanges, particularly where they involved literally true utterances & literally true positive & negative remarks. However, patients had difficulty interpreting literally false utterances. It is suggested that this may be due to inability or unwillingness to understand mutual knowledge & impute mental states to others. 4 Tables, 27 References. B. Annesser Murray JF - Brain and Language AU - Kaplan, Joan A AU - Brownell, Hiram H AU - Jacobs, Janet R AU - Gardner, Howard AD - c/o Brownell-Psychology Service 116B Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 315 EP - 333 VL - 38 IS - 2 SN - 0093-934X, 0093-934X KW - conversational remarks pragmatic interpretation, right hemisphere damage effects KW - Language Pathology (la4) KW - Truth (tr8) KW - Pragmatics (pq1) KW - Meaning (me1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85508952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Effects+of+Right+Hemisphere+Damage+on+the+Pragmatic+Interpretation+of+Conversational+Remarks&rft.au=Kaplan%2C+Joan+A%3BBrownell%2C+Hiram+H%3BJacobs%2C+Janet+R%3BGardner%2C+Howard&rft.aulast=Kaplan&rft.aufirst=Joan&rft.date=1990-02-01&rft.volume=38&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Pragmatics (pq1); Meaning (me1); Truth (tr8) ER - TY - JOUR T1 - Anatomy of the root apex and its histologic changes with age. AN - 85258724; pmid-2304750 AB - There were 87 vital and 24 nonvital teeth for a total of 111 specimens from 47 patients. The specimens were prepared to a thickness of 500 microns with a Buehler Isomet Bone Saw. Distances were measured and recorded with a Bioquant II Image Analysis System. The mean age of the patients was 48.9 years. The median age was 52 years. The range was 51 years, with a maximum of 77 years and a minimum of 26 years. There is a positive correlation, which could not have occurred by chance, that as age increases the deviation and the width of the foramen opening both increase. This increase appears to be a result of apical cemental thickening that occurs as the patient ages. The tissue in the apical area seems to be capable of generating additional cementum as the tooth ages. The cementodentinal junction width, or most apical extent of the dentin, remains constant. JF - Oral surgery, Oral Medicine, and Oral Pathology AU - Stein, T J AU - Corcoran, J F AD - Allen Park Veterans Administration Medical Center. PY - 1990 SP - 238 EP - 242 VL - 69 IS - 2 SN - 0030-4220, 0030-4220 KW - Dentin KW - Regression Analysis KW - Dental Cementum KW - Human KW - Adult KW - Aged KW - Middle Age KW - Odontometry KW - Female KW - Male KW - Tooth Root KW - Aging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85258724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+surgery%2C+Oral+Medicine%2C+and+Oral+Pathology&rft.atitle=Anatomy+of+the+root+apex+and+its+histologic+changes+with+age.&rft.au=Stein%2C+T+J%3BCorcoran%2C+J+F&rft.aulast=Stein&rft.aufirst=T&rft.date=1990-02-01&rft.volume=69&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Oral+surgery%2C+Oral+Medicine%2C+and+Oral+Pathology&rft.issn=00304220&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal antiinflammatory drug therapy. AN - 85211272; pmid-2303676 AB - Endoscopy in 49 patients without upper gastrointestinal symptoms and who were receiving chronic aspirin or nonsteroidal antiinflammatory drug therapy showed the frequency of gastric and duodenal mucosal lesions to be 76 and 27%, respectively. Fifteen (31%) had gastric ulcers, 31 (63%) had gastric erosions, and 10 (20%) had gastric mucosal hemorrhages. Gastric mucosal lesions were noted in 9 (90%) patients taking plain aspirin, in 25 (74%) receiving nonsteroidal antiinflammatory agents, and in 3 (60%) patients taking enteric-coated aspirin. Duodenal lesions were noted in 30 and 26% of patients taking plain aspirin and nonsteroidal antiinflammatory drugs, respectively. Patients taking enteric-coated aspirin had less severe duodenal injury than patients receiving ibuprofen or indomethacin, but the difference was not statistically significant. Endoscopy in 20 normal subjects not taking aspirin or nonsteroidal antiinflammatory drugs showed no gastroduodenal ulcers, erosions, or hemorrhage. Patients chronically taking antiarthritic drugs, including enteric-coated aspirin, have a high frequency of asymptomatic gastroduodenal lesions. JF - Journal of Clinical Gastroenterology AU - Jaszewski, R AD - Division of Gastroenterology, Veterans Administration Medical Center, Allen Park, Michigan 48101. PY - 1990 SP - 10 EP - 13 VL - 12 IS - 1 SN - 0192-0790, 0192-0790 KW - Human KW - Joint Diseases KW - Aged KW - Endoscopy KW - Prospective Studies KW - Stomach Diseases KW - Aspirin KW - Adult KW - Middle Age KW - Anti-Inflammatory Agents, Non-Steroidal KW - Male KW - Duodenal Diseases KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Frequency+of+gastroduodenal+lesions+in+asymptomatic+patients+on+chronic+aspirin+or+nonsteroidal+antiinflammatory+drug+therapy.&rft.au=Jaszewski%2C+R&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1990-02-01&rft.volume=12&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A critical reevaluation of the Quantified Denver Scale of Communication Function. AN - 85147890; pmid-2307305 AB - The Quantified Denver Scale of Communication Function (QDS) is a 25 item questionnaire developed to measure communication difficulties in adults with hearing impairment. This study reassessed the constructs, reliability, and validity of the scale, and developed a 5 item short version. The QDS was administered to 238 elderly individuals (137 with and 101 without hearing loss). Factor analysis using this sample identified only two subscale constructs as opposed to four originally proposed constructs. The validity of the new revised two-construct model was verified by four independent investigators who labeled the two constructs as measuring self isolation and communication function. The internal reliability of the revised scale was 0.97 and of both construct subscales was 0.95. Overall test-retest reliability was 0.73. Validity examined by comparing the revised scale with another well-known handicap measure, the Hearing Handicap Inventory for the Elderly, was adequate: overall scale correlations were 0.73 and subscale correlations ranged from 0.64 to 0.72. The accuracy of the revised QDS for discriminating between individuals with and without hearing loss was 73%. Stepwise discriminant analysis generated a 5 item short version scale which contained two questions from the long communication subscale and three from the long self-isolation subscale. The accuracy of the short QDS was 74%. We conclude that the revised QDS is a reliable and valid scale that can be used to assess self isolation and communication function in elderly individuals with hearing loss, and that a new 5 item short version performs as well as the original 25 item scale. JF - Ear and Hearing AU - Tuley, M R AU - Mulrow, C D AU - Aguilar, C AU - Velez, R AD - Health Services Research, Audie I. Murphy Memorial Veterans Administration Hospital, San Antonio, Texas. PY - 1990 SP - 56 EP - 61 VL - 11 IS - 1 SN - 0196-0202, 0196-0202 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85147890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+Hearing&rft.atitle=A+critical+reevaluation+of+the+Quantified+Denver+Scale+of+Communication+Function.&rft.au=Tuley%2C+M+R%3BMulrow%2C+C+D%3BAguilar%2C+C%3BVelez%2C+R&rft.aulast=Tuley&rft.aufirst=M&rft.date=1990-02-01&rft.volume=11&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Ear+and+Hearing&rft.issn=01960202&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The incidence of communication disorders in dysphagic patients. AN - 85147330; pmid-2299837 AB - A retrospective study investigated the incidence and types of communication problems in 115 patients referred for swallowing difficulties. Each patient had a bedside swallowing evaluation completed as well as a screening of communication abilities. A formal speech-language evaluation was done when warranted and possible. Of the 115 patients, 93 had suspected swallowing problems based on the bedside evaluation done by the speech-language pathologist. Videofluoroscopy was performed on 85 of these patients. A significant positive correlation was found between communication impairments and both suspected and videofluoroscopically confirmed dysphagia. Cognitive problems were the most frequent communication impairment with dysarthria being second. Neurological diseases were the most common medical diagnoses in patients with swallowing difficulties. The case is presented for the speech-language pathologist to be the primary diagnostician and manager of both communication and oral-pharyngeal swallowing disorders whether they co-occur or not. JF - The Journal of Speech and Hearing Disorders AU - Martin, B J AU - Corlew, M M AD - Celement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI. PY - 1990 SP - 28 EP - 32 VL - 55 IS - 1 SN - 0022-4677, 0022-4677 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85147330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Speech+and+Hearing+Disorders&rft.atitle=The+incidence+of+communication+disorders+in+dysphagic+patients.&rft.au=Martin%2C+B+J%3BCorlew%2C+M+M&rft.aulast=Martin&rft.aufirst=B&rft.date=1990-02-01&rft.volume=55&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Speech+and+Hearing+Disorders&rft.issn=00224677&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The Addiction Severity Index: predicting relationship to a hospital and a professional. AN - 80079730; 2228332 AB - The Addiction Severity Index was developed to be a useful instrument in treatment planning for the substance abuser. Multivariate statistical tests were conducted on the questionnaire for a clinical sample of 190 males at a Veterans Administration hospital. When the desire for psychological treatment with a specific person was taken into consideration, the overall predictive validity of the instrument in designating discharge accounted for 69% of the variance rather than 24% of the variance. This finding could challenge the myth that substance abusers and patients from lower socioeconomic levels are not psychologically minded and not capable of being engaged in psychological process treatment. This finding is also relevant to governmental concerns for quality assurance and cost effectiveness, since it can be utilized to both improve treatment planning and delete irrelevant documentation and assessment procedures. JF - The International journal of the addictions AU - Rogalski, C J AD - West Side Veterans Administration Hospital, Chicago, Illinois 60612. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 179 EP - 193 VL - 25 IS - 2 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Hospitalization KW - Combined Modality Therapy KW - Humans KW - Adult KW - Prognosis KW - Opioid-Related Disorders -- rehabilitation KW - Middle Aged KW - Psychometrics KW - Professional-Patient Relations KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Psychotherapy KW - Personality Tests KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80079730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=The+Addiction+Severity+Index%3A+predicting+relationship+to+a+hospital+and+a+professional.&rft.au=Rogalski%2C+C+J&rft.aulast=Rogalski&rft.aufirst=C&rft.date=1990-02-01&rft.volume=25&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-04 N1 - Date created - 1990-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Successful treatment using gentamicin liposomes of Salmonella dublin infections in mice. AN - 79733883; 2327780 AB - Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All mice survived after treatment with a single i.v. or intraperitoneal injection of 20 mg of gentamicin liposomes per kg, whereas that dose of free drug was completely ineffective and caused neuromuscular paralysis when injected rapidly i.v. In mice treated with gentamicin liposomes, there was a steady decrease in the number of salmonellae in spleens for 2 weeks after treatment. High concentrations of gentamicin were present in the spleen for at least 10 days after treatment. Although gentamicin was not detected in the mesenteric lymph nodes of mice treated with gentamicin liposomes, bacterial counts in the nodes also decreased over time. Small numbers of bacteria remained viable in the mesenteric lymph nodes and Peyer's patches but not in the spleens of mice treated with 20 to 80 mg/kg. Mice treated with doses of gentamicin liposomes as high as 80 mg/kg showed only a transient increase in blood urea nitrogen and no rise in serum creatinine. These results confirm that gentamicin in liposomes is less toxic in mice than is free gentamicin and is extremely effective therapy for disseminated Salmonella infections in mice. JF - Antimicrobial agents and chemotherapy AU - Fierer, J AU - Hatlen, L AU - Lin, J P AU - Estrella, D AU - Mihalko, P AU - Yau-Young, A AD - Department of Medicine and Pathology, Veterans Administration Medical Center, San Diego, California. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 343 EP - 348 VL - 34 IS - 2 SN - 0066-4804, 0066-4804 KW - Gentamicins KW - 0 KW - Liposomes KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Culture Techniques KW - Injections, Intravenous KW - Spleen -- metabolism KW - Lymph Nodes -- microbiology KW - Mice KW - Mice, Inbred BALB C KW - Peyer's Patches -- microbiology KW - Female KW - Salmonella Infections, Animal -- microbiology KW - Gentamicins -- pharmacokinetics KW - Gentamicins -- therapeutic use KW - Gentamicins -- administration & dosage KW - Salmonella Infections, Animal -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79733883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Successful+treatment+using+gentamicin+liposomes+of+Salmonella+dublin+infections+in+mice.&rft.au=Fierer%2C+J%3BHatlen%2C+L%3BLin%2C+J+P%3BEstrella%2C+D%3BMihalko%2C+P%3BYau-Young%2C+A&rft.aulast=Fierer&rft.aufirst=J&rft.date=1990-02-01&rft.volume=34&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1978 Oct;89(4):528-38 [358884] J Infect Dis. 1987 Sep;156(3):510-3 [3611835] Cancer Res. 1981 Feb;41(2):487-94 [7448797] Cancer Res. 1981 Apr;41(4):1311-7 [7214320] Cancer Res. 1982 Apr;42(4):1412-22 [7060015] Immunology. 1982 Apr;45(4):769-74 [7068173] Proc Natl Acad Sci U S A. 1982 Mar;79(5):1663-7 [6951205] Cell. 1983 Apr;32(4):1069-79 [6404557] J Infect Dis. 1983 Sep;148(3):563-70 [6352828] J Reticuloendothel Soc. 1983 Oct;34(4):279-87 [6352935] J Biol Response Mod. 1983;2(2):97-100 [6644336] Pharmacol Ther. 1983;22(3):407-24 [6361805] J Pharmacol Exp Ther. 1984 Apr;229(1):267-75 [6707942] Vet Immunol Immunopathol. 1985 Jan;8(1-2):171-82 [3919496] Eur J Biochem. 1985 Apr 15;148(2):391-7 [3987696] J Infect Dis. 1985 May;151(5):917-24 [3921624] J Infect Dis. 1985 Sep;152(3):529-35 [2411828] Antimicrob Agents Chemother. 1985 Jul;28(1):28-32 [3899004] Res Commun Chem Pathol Pharmacol. 1985 Nov;50(2):281-90 [2417296] J Infect Dis. 1987 Jun;155(6):1254-9 [3572038] Antimicrob Agents Chemother. 1987 May;31(5):675-8 [3300535] Antimicrob Agents Chemother. 1980 Apr;17(4):544-8 [7396450] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs. AN - 79691007; 2156794 AB - The effects of endothelium-dependent vasodilation on pulmonary vascular hemodynamics were evaluated in a variety of in vivo and in vitro models to determine 1) the comparability of the hemodynamic effects of acetylcholine (ACh), bradykinin (BK), nitric oxide (NO), and 8-bromo-guanosine 3',5'-cyclic monophosphate (cGMP), 2) whether methylene blue is a useful inhibitor of endothelium-dependent relaxing factor (EDRF) activity in vivo, and 3) the effect of monocrotaline-induced pulmonary hypertension on the responsiveness of the pulmonary vasculature to ACh. In isolated rat lungs, which were preconstricted with hypoxia, ACh, BK, NO, and 8-bromo-cGMP caused pulmonary vasodilation, which was not inhibited by maximum tolerable doses of methylene blue. Methylene blue did not inhibit EDRF activity in any model, despite causing increased pulmonary vascular tone and responsiveness to various constrictor agents. There were significant differences in the hemodynamic characteristics of ACh, BK, and NO. In the isolated lung, BK and NO caused transient decreases of hypoxic vasoconstriction, whereas ACh caused more prolonged vasodilation. Pretreatment of these lungs with NO did not significantly inhibit ACh-induced vasodilation but caused BK to produce vasoconstriction. Tachyphylaxis, which was agonist specific, developed with repeated administration of ACh or BK but not NO. Tachyphylaxis probably resulted from inhibition of the endothelium-dependent vasodilation pathway proximal to NO synthesis, because it could be overcome by exogenous NO. Pretreatment with 8-bromo-cGMP decreased hypoxic pulmonary vasoconstriction and, even when the hypoxic pressor response had largely recovered, subsequent doses of ACh and NO failed to cause vasodilation, although BK produced vasoconstriction. These findings are compatible with the existence of feedback inhibition of the endothelium-dependent relaxation by elevation of cGMP levels. Responsiveness to ACh was retained in lungs with severe monocrotaline-induced pulmonary hypertension. Many of these findings would not have been predicted based on in vitro studies and illustrate the importance for expanding studies of EDRF to in vivo and ex vivo models. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Archer, S L AU - Rist, K AU - Nelson, D P AU - DeMaster, E G AU - Cowan, N AU - Weir, E K AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota 55407. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 735 EP - 747 VL - 68 IS - 2 SN - 8750-7587, 8750-7587 KW - Pyrrolizidine Alkaloids KW - 0 KW - 8-bromocyclic GMP KW - 31356-94-2 KW - Nitric Oxide KW - 31C4KY9ESH KW - Monocrotaline KW - 73077K8HYV KW - Cyclic GMP KW - H2D2X058MU KW - Acetylcholine KW - N9YNS0M02X KW - Bradykinin KW - S8TIM42R2W KW - Methylene Blue KW - T42P99266K KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Cyclic GMP -- pharmacology KW - Hypertension, Pulmonary -- physiopathology KW - Acetylcholine -- pharmacology KW - Pyrrolizidine Alkaloids -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Methylene Blue -- pharmacology KW - Hypertension, Pulmonary -- chemically induced KW - Bradykinin -- pharmacology KW - Cyclic GMP -- analogs & derivatives KW - Hypoxia -- physiopathology KW - Male KW - Lung -- blood supply KW - Pulmonary Circulation -- drug effects KW - Nitric Oxide -- pharmacology KW - Vasodilation -- drug effects KW - Pulmonary Circulation -- physiology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79691007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Comparison+of+the+hemodynamic+effects+of+nitric+oxide+and+endothelium-dependent+vasodilators+in+intact+lungs.&rft.au=Archer%2C+S+L%3BRist%2C+K%3BNelson%2C+D+P%3BDeMaster%2C+E+G%3BCowan%2C+N%3BWeir%2C+E+K&rft.aulast=Archer&rft.aufirst=S&rft.date=1990-02-01&rft.volume=68&rft.issue=2&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-01 N1 - Date created - 1990-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transfection of calcitonin gene regulatory elements into a cell culture model of the C cell. AN - 79685297; 2316404 AB - Calcitonin gene expression in the TT cell line can be regulated by phorbol esters, cAMP, glucocorticoids, and 1,25-dihydroxyvitamin D3. To further study the regulation of this gene we have sequenced 1460 bases 5' to the start of calcitonin gene transcription. This DNA sequence contains cis consensus elements for both phorbol ester- and cAMP-responsive elements. To study the role of these elements, calcitonin 5' flanking DNA was coupled to the human growth hormone gene as a reporter and transiently transfected into TT cells, a human thyroid C cell line. Treatment of transfected TT cells stimulated a two- to fivefold increase in reported gene product expression, confirming the existence of functional cAMP- and phorbol ester-dependent enhancers within the calcitonin 5' flanking sequence. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Cote, G J AU - Abruzzese, R V AU - Lips, C J AU - Gagel, R F AD - Department of Medicine, Veterans Administration Medical Center, Houston, TX. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 165 EP - 171 VL - 5 IS - 2 SN - 0884-0431, 0884-0431 KW - Colforsin KW - 1F7A44V6OU KW - Growth Hormone KW - 9002-72-6 KW - Calcitonin KW - 9007-12-9 KW - DNA KW - 9007-49-2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Colforsin -- pharmacology KW - Base Sequence KW - Tumor Cells, Cultured KW - Plasmids -- genetics KW - Humans KW - DNA -- genetics KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Models, Biological KW - Growth Hormone -- metabolism KW - Cloning, Molecular KW - Regulatory Sequences, Nucleic Acid -- genetics KW - Transfection -- genetics KW - Calcitonin -- genetics KW - Thyroid Gland -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79685297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Transfection+of+calcitonin+gene+regulatory+elements+into+a+cell+culture+model+of+the+C+cell.&rft.au=Cote%2C+G+J%3BAbruzzese%2C+R+V%3BLips%2C+C+J%3BGagel%2C+R+F&rft.aulast=Cote&rft.aufirst=G&rft.date=1990-02-01&rft.volume=5&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-23 N1 - Date created - 1990-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - U937 and THP-1 cells do not release LTB4, LTC4, or LTD4 in response to A23187. AN - 79683104; 2156322 AB - U937 and THP-1 cells possess some characteristics of human mononuclear phagocytes, cells which synthesize and release LTB4, LTC4, and LTD4. Incubation of these cells with recombinant human interferon-gamma (IFN-gamma) or Phorbol Myristate Acetate (PMA) induces a more differentiated cell state. We hypothesized that U937 and THP-1 cells would release LTB4, LTC4, and LTD4 in response to stimulation with the non-physiologic agonist, calcium ionophore A23187 and that preincubation with IFN-gamma or PMA might alter leukotriene release by these cells. We cultured both cell lines for 48 hours in the presence and absence of IFN-gamma (1000 units/ml) and for 120 hours in the presence and absence of PMA (160 nM) and then challenged them with A23187 (5uM) for 30 minutes at 37 degrees C. The supernatants were deproteinated and assayed by RIA for LTB4 and LTC4 and by RP-HPLC for LTB4, LTC4, and LTD4. Neither U937 nor THP-1 cells released quantities of leukotrienes detectable by RIA, less than 0.3ng/5 X 10(6) cells. Peripheral blood mononuclear phagocytes from normal volunteers, cultured and challenged in vitro at under identical conditions, released 11.3 +/- 2.9 ng LTB4 and 2.0 +/- 1.5 ng LTC4/10(6) viable monocytes. The lack of leukotriene production by U937 and THP-1 cells was not altered by preincubation for 48 hours with IFN-gamma (n = 3) nor by preincubation with PMA for 120 hours (n = 3). We conclude 1) U937 and THP-1 cells do not appear to be appropriate in vitro models for the examination of leukotriene release from normal mononuclear phagocytes. 2) Pre-incubation of U937 and THP-1 cells with IFN-gamma or PMA under the conditions tested, does not induce the ability of these cell lines to release leukotrienes. JF - Prostaglandins AU - Nolfo, R AU - Rankin, J A AD - Department of Medicine, West Haven Veterans Administration Hospital, Connecticut. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 157 EP - 165 VL - 39 IS - 2 SN - 0090-6980, 0090-6980 KW - SRS-A KW - 0 KW - Leukotriene B4 KW - 1HGW4DR56D KW - Calcimycin KW - 37H9VM9WZL KW - Interferon-gamma KW - 82115-62-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Monocytes -- secretion KW - Humans KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects KW - Interferon-gamma -- pharmacology KW - Tumor Cells, Cultured -- secretion KW - Tumor Cells, Cultured -- drug effects KW - SRS-A -- secretion KW - Calcimycin -- pharmacology KW - Leukotriene B4 -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79683104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins&rft.atitle=U937+and+THP-1+cells+do+not+release+LTB4%2C+LTC4%2C+or+LTD4+in+response+to+A23187.&rft.au=Nolfo%2C+R%3BRankin%2C+J+A&rft.aulast=Nolfo&rft.aufirst=R&rft.date=1990-02-01&rft.volume=39&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Prostaglandins&rft.issn=00906980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - P47 phosphoprotein of blood platelets (pleckstrin) is a major target for phorbol ester-induced protein phosphorylation in intact platelets, granulocytes, lymphocytes, monocytes and cultured leukaemic cells: absence of P47 in non-haematopoietic cells. AN - 79681413; 2317454 AB - Aggregating agents including phorbol esters which activate protein kinase C induce the rapid phosphorylation of a Mr = 47,000 cytosolic protein in blood platelets (P47 or pleckstrin). This protein is well resolved by analytical 16-BAC----SDS two-dimensional PAGE and was purified from platelets by preparative 16-BAC----SDS PAGE. Polyclonal antibodies were raised to the protein in mice and rabbits. These antisera detected a single protein with the migration of P47 on Western blots of platelet extracts, and the rabbit antisera immunoprecipitated 32P-labelled P47 from platelet cytosol. The presence of P47 in other haematopoietic cells was determined by prelabelling them with 32P and observing increased 32P incorporation into the location of P47 on autoradiographs of 16-BAC----SDS analytical PAGE of cells exposed to phorbol ester. The identity of the phosphoprotein found in this location was further established by probing Western blots of SDS PAGE gels of cultured cell lines with the P47 antisera. P47 was detected in peripheral blood lymphocytes, monocytes and granulocytes (including the granulocytes of two unrelated patients with X-linked chronic granulomatous disease). P47 was also found in HL-60 promyelocytes (especially after differentiation with retinoic acid), U937 histiocytes, HEL leukaemia cells, and Raji 'B' lymphoblasts. It was not detected in normal erythrocytes, K562 leukaemic cells, MOLT-3 'T' lymphoblasts, or in wide range of non-haematopoietic cell lines. We conclude that P47 is a major target for the action of phorbol ester induced phosphorylation in platelets, normal leucocytes and some haematopoietic cell lines. These cells have as their common feature the ability when stimulated to develop adhesive functions on their plasma membranes. JF - British journal of haematology AU - Gailani, D AU - Fisher, T C AU - Mills, D C AU - Macfarlane, D E AD - Department of Medicine, Veterans Administration, Iowa City, Iowa. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 192 EP - 202 VL - 74 IS - 2 SN - 0007-1048, 0007-1048 KW - Blood Proteins KW - 0 KW - Phosphoproteins KW - platelet protein P47 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Blotting, Western KW - Tumor Cells, Cultured -- metabolism KW - Phosphorylation KW - Granulocytes -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - Cells, Cultured KW - Humans KW - Monocytes -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lymphocytes -- metabolism KW - Leukocytes -- metabolism KW - Blood Proteins -- isolation & purification KW - Leukemia -- blood KW - Blood Platelets -- metabolism KW - Blood Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79681413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=P47+phosphoprotein+of+blood+platelets+%28pleckstrin%29+is+a+major+target+for+phorbol+ester-induced+protein+phosphorylation+in+intact+platelets%2C+granulocytes%2C+lymphocytes%2C+monocytes+and+cultured+leukaemic+cells%3A+absence+of+P47+in+non-haematopoietic+cells.&rft.au=Gailani%2C+D%3BFisher%2C+T+C%3BMills%2C+D+C%3BMacfarlane%2C+D+E&rft.aulast=Gailani&rft.aufirst=D&rft.date=1990-02-01&rft.volume=74&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=00071048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-03 N1 - Date created - 1990-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis. AN - 79652132; 2307396 AB - A high-fat diet has previously been shown to be a key factor for induction of alcoholic liver fibrosis in a rat model of intragastric ethanol infusion. To explore a possible mechanism by which the high-fat diet facilitated such an effect, the present study examined how the high-fat diet with or without ethanol affected proliferation and collagen formation of hepatic lipocytes, perisinusoidal cells that have been suggested to be involved in liver fibrogenesis. We also evaluated effects of the high-fat diet on the sensitivity of lipocytes to stimulatory effects of Kupffer cell-derived factors. Intragastric infusion of ethanol and the high-fat diet for 9 to 10 wk resulted in induction of a varying degree of perivenular fibrosis in 75% of animals. Lipocytes isolated from these animals (A) had significantly higher basal rates of proliferation (three to four times) and collagen formation (1.5 times) than those isolated from control animals, which were isocalorically infused with the high-fat diet (H) or the low-fat diet (L), or those that were fed chow ad libitum (C). Lipocytes from the H group exhibited significantly higher relative production of collagen than those from the L group, but their net collagen production was not enhanced. The dialyzed Kupffer cell-conditioned medium from the A group markedly stimulated proliferation and collagen formation of lipocytes from the groups given the high-fat diet (A and H) but had minimal effects on those from the L and C groups, establishing the order of decreasing lipocyte sensitivity from the A, H, L to C group. Similarly, lipocytes from the H and A groups exhibited a more profound responsiveness to the stimulatory effect of transforming growth factor beta 1 on collagen formation. These results demonstrate (a) that lipocytes isolated from the rats given the high-fat diet and ethanol are markedly proliferative and produce more collagen; and (b) that the Kupffer cells derived from these animals release factors that stimulate proliferation and collagen formation of lipocytes and (c) that the high-fat diet sensitizes lipocytes for stimulatory effects of the Kupffer cell-derived factors and transforming growth factor beta 1. JF - Hepatology (Baltimore, Md.) AU - Matsuoka, M AU - Zhang, M Y AU - Tsukamoto, H AD - Hepatopancreatic Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 173 EP - 182 VL - 11 IS - 2 SN - 0270-9139, 0270-9139 KW - Dietary Fats KW - 0 KW - Transforming Growth Factors KW - 76057-06-2 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cells, Cultured KW - In Vitro Techniques KW - Transforming Growth Factors -- pharmacology KW - Collagen -- biosynthesis KW - Cell Division KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Dietary Fats -- metabolism KW - Liver Cirrhosis, Alcoholic -- pathology KW - Kupffer Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79652132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Sensitization+of+hepatic+lipocytes+by+high-fat+diet+to+stimulatory+effects+of+Kupffer+cell-derived+factors%3A+implication+in+alcoholic+liver+fibrogenesis.&rft.au=Matsuoka%2C+M%3BZhang%2C+M+Y%3BTsukamoto%2C+H&rft.aulast=Matsuoka&rft.aufirst=M&rft.date=1990-02-01&rft.volume=11&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-05 N1 - Date created - 1990-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of buspirone in seven schizophrenic subjects. AN - 79651466; 1968473 JF - Journal of clinical psychopharmacology AU - Brody, D AU - Adler, L A AU - Kim, T AU - Angrist, B AU - Rotrosen, J AD - New York Veterans Administration Medical Center, Psychiatry Service, New York. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 68 EP - 69 VL - 10 IS - 1 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Drug Therapy, Combination KW - Psychiatric Status Rating Scales KW - Humans KW - Antipsychotic Agents -- administration & dosage KW - Buspirone -- administration & dosage KW - Buspirone -- adverse effects KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79651466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Effects+of+buspirone+in+seven+schizophrenic+subjects.&rft.au=Brody%2C+D%3BAdler%2C+L+A%3BKim%2C+T%3BAngrist%2C+B%3BRotrosen%2C+J&rft.aulast=Brody&rft.aufirst=D&rft.date=1990-02-01&rft.volume=10&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-09 N1 - Date created - 1990-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - HeLa cells express cAMP-inhibitable sodium-dependent phosphate uptake. AN - 79651425; 2155543 AB - Receptor-mediated regulation of the sodium-phosphate symporter, and hence sodium-dependent phosphate uptake, typically relates to epithelial cells of renal origin. In this study we have characterized sodium-dependent phosphate uptake and aspects of its receptor-mediated regulation in the HeLa cell line, a cell line derived from a human epithelioid carcinoma. Phosphate uptake (greater than 90% sodium dependent; Vmax = 4.02 +/- 0.24 nmol.mg and Km = 0.11 +/- 0.02 mM phosphate at 140 mM sodium) was kinetically similar to that observed in opossum kidney cells. Incubation with vasoactive intestinal peptide (VIP) resulted in a dose-dependent (50% maximal dose of 8.8 +/- 3.6 nM) approximately fivefold increase in basal adenosine 3',5'-cyclic monophosphate (cAMP) levels (basal = 14.6 +/- 1.7 pmol.mg protein-1.15 min-1; VIP stimulated = 72.7 +/- 13.2 pmol.mg protein-1.15 min-1), as well as a dose-dependent maximal 32.6 +/- 5.5% decrease in sodium-dependent phosphate uptake (50% maximal decrease of 46.2 +/- 21.2 nM). The VIP-induced decrease in phosphate uptake was due to decrease in maximal transport (VmaxVIP = 2.78 +/- 0.16 nmol.mg protein-1.3 min-1) and not to a change in the affinity of the transporter for phosphate (KmVIP = 0.11 +/- 0.01 mM phosphate). Preincubation of HeLa cells with forskolin and cholera toxin, which stimulate adenylate cyclase, resulted in dose-dependent decreases in sodium-dependent phosphate uptake. Incubation with 8-bromo-cAMP and dibutyryl cAMP, permeant analogues of cAMP, similarly resulted in a dose-dependent decrease in sodium-dependent phosphate uptake.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of physiology AU - Raymond, J R AU - Middleton, J P AU - Dennis, V W AD - Medical Service (Nephrology Section), Durham Veterans Administration Medical Center, North Carolina. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - F433 EP - F437 VL - 258 IS - 2 Pt 2 SN - 0002-9513, 0002-9513 KW - Phosphates KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Bucladesine KW - 63X7MBT2LQ KW - Cholera Toxin KW - 9012-63-9 KW - Sodium KW - 9NEZ333N27 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Vasoactive Intestinal Peptide -- pharmacology KW - Colforsin -- pharmacology KW - Kinetics KW - Humans KW - Cholera Toxin -- pharmacology KW - Bucladesine -- pharmacology KW - Time Factors KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Phosphates -- metabolism KW - HeLa Cells -- metabolism KW - Phosphates -- antagonists & inhibitors KW - Cyclic AMP -- pharmacology KW - Cyclic AMP -- metabolism KW - Sodium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79651425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=HeLa+cells+express+cAMP-inhibitable+sodium-dependent+phosphate+uptake.&rft.au=Raymond%2C+J+R%3BMiddleton%2C+J+P%3BDennis%2C+V+W&rft.aulast=Raymond&rft.aufirst=J&rft.date=1990-02-01&rft.volume=258&rft.issue=2+Pt+2&rft.spage=F433&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-03 N1 - Date created - 1990-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A patient with simultaneous absence of "classical" natural killer cells (CD3-, CD16+, and NKH1+) and expansion of CD3+, CD4-, CD8-, NKH1+ subset. AN - 79619943; 2303649 AB - The clinical manifestations of putative natural killer (NK) cell deficiency are not well-known but theoretically should include recurrent tumors and systemic viral infections. In this article, we discuss a patient with recurrent condylomata, vulvar and cervical carcinoma in situ, pulmonary infiltrates of unknown significance, and a hypercoagulable state. This patient has a dramatic persistent deficiency in her circulating "classic" NK cells (CD3-, CD16+, NKH1+) and a simultaneous persistent expansion of a normally minor lymphocyte cell subset (CD3+, CD4-, CD8-, NKH1+) that does not express the alpha beta heterodimer of the T cell receptor. T-lymphocyte function, as measured by mitogen and alloantigen responsiveness in vitro, was normal. The coexistence of this particular clinical complex with this unusual set of laboratory abnormalities tends to emphasize our meager understanding of the biologic role of NK cells. At the very least, these findings suggest that the clinical manifestations of NK cell deficiency need not be dominated by disseminated systemic viral infections and that perhaps there should be a higher index of suspicion for the scrutinization of NK cell function. JF - The Journal of allergy and clinical immunology AU - Ballas, Z K AU - Turner, J M AU - Turner, D A AU - Goetzman, E A AU - Kemp, J D AD - Iowa City Veterans Administration, Iowa. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 453 EP - 459 VL - 85 IS - 2 SN - 0091-6749, 0091-6749 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Immunoglobulins KW - Abridged Index Medicus KW - Index Medicus KW - Immunoglobulins -- analysis KW - Anus Neoplasms -- immunology KW - Condylomata Acuminata -- immunology KW - Vulvar Neoplasms -- immunology KW - Humans KW - Killer Cells, Lymphokine-Activated -- immunology KW - Neoplasms, Multiple Primary -- immunology KW - Carcinoma, Squamous Cell -- immunology KW - Neoplasm Recurrence, Local -- immunology KW - Adult KW - Cytotoxicity Tests, Immunologic KW - Flow Cytometry KW - Uterine Cervical Neoplasms -- immunology KW - Carcinoma in Situ -- immunology KW - Female KW - Immunologic Deficiency Syndromes -- immunology KW - Antigens, CD -- analysis KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79619943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=A+patient+with+simultaneous+absence+of+%22classical%22+natural+killer+cells+%28CD3-%2C+CD16%2B%2C+and+NKH1%2B%29+and+expansion+of+CD3%2B%2C+CD4-%2C+CD8-%2C+NKH1%2B+subset.&rft.au=Ballas%2C+Z+K%3BTurner%2C+J+M%3BTurner%2C+D+A%3BGoetzman%2C+E+A%3BKemp%2C+J+D&rft.aulast=Ballas&rft.aufirst=Z&rft.date=1990-02-01&rft.volume=85&rft.issue=2&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - CNS tumor induction by radiotherapy: a report of four new cases and estimate of dose required. AN - 79615998; 2137438 AB - We have analyzed 60 cases of intra-axial brain tumors associated with antecedent radiation therapy. These include four new cases. The patients had originally received radiation therapy for three reasons: (a) cranial irradiation for acute lymphoblastic leukemia (ALL), (b) definitive treatment of CNS neoplasia, and (c) treatment of benign disease (mostly cutaneous infections). The number of cases reported during the past decade has greatly increased as compared to previous years. Forty-six of the 60 intra-axial tumors have been reported since 1978. The relative risk of induction of an intra-axial brain tumor by radiation therapy is estimated to be more than 100, as compared to individuals who have not had head irradiation. JF - International journal of radiation oncology, biology, physics AU - Cavin, L W AU - Dalrymple, G V AU - McGuire, E L AU - Maners, A W AU - Broadwater, J R AD - Nuclear Medicine Service, John L. McClellan Veterans Administration Hospital, Little Rock, AR 72205. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 399 EP - 406 VL - 18 IS - 2 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Animals KW - Tinea Capitis -- radiotherapy KW - Neoplasms, Experimental -- etiology KW - Humans KW - Meningeal Neoplasms -- prevention & control KW - Child, Preschool KW - Infant KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- radiotherapy KW - Radiotherapy Dosage KW - Adult KW - Macaca mulatta KW - Meta-Analysis as Topic KW - Female KW - Male KW - Brain Neoplasms -- radiotherapy KW - Neoplasms, Radiation-Induced KW - Radiotherapy -- adverse effects KW - Brain Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79615998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=CNS+tumor+induction+by+radiotherapy%3A+a+report+of+four+new+cases+and+estimate+of+dose+required.&rft.au=Cavin%2C+L+W%3BDalrymple%2C+G+V%3BMcGuire%2C+E+L%3BManers%2C+A+W%3BBroadwater%2C+J+R&rft.aulast=Cavin&rft.aufirst=L&rft.date=1990-02-01&rft.volume=18&rft.issue=2&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-29 N1 - Date created - 1990-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Complement levels in patients with hepatic dysfunction. AN - 79612712; 2302981 AB - Total hemolytic complement activity and serum complement protein concentrations were compared in 17 hospitalized patients with normal hepatic function and 16 patients with liver disease due to alcohol (15 patients) or acetaminophen toxicity (one patient). In contrast to the control patients, individuals with hepatic dysfunction had decreased total CH50 levels and low concentrations of total C3, C4, C5, factor B, and the regulatory proteins factor I and beta-1H. These patients also had increased C4d/C4 ratios, indicating classical pathway activation. The level of complement deficiency appears to correlate with either prolongation of the prothrombin time or depression of serum albumin concentration. These results indicate that patients with hepatic disease have severe complement depletion that is probably multifactorial in origin. This impairment in complement function will contribute to the impaired antibacterial host defense of the patient with chronic hepatic disease. JF - Digestive diseases and sciences AU - Ellison, R T AU - Horsburgh, C R AU - Curd, J AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 231 EP - 235 VL - 35 IS - 2 SN - 0163-2116, 0163-2116 KW - Complement System Proteins KW - 9007-36-7 KW - Abridged Index Medicus KW - Index Medicus KW - Reference Values KW - Humans KW - Retrospective Studies KW - Liver -- metabolism KW - Prothrombin Time KW - Male KW - Female KW - Liver Diseases -- blood KW - Complement System Proteins -- deficiency KW - Complement System Proteins -- analysis KW - Liver Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79612712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Complement+levels+in+patients+with+hepatic+dysfunction.&rft.au=Ellison%2C+R+T%3BHorsburgh%2C+C+R%3BCurd%2C+J&rft.aulast=Ellison&rft.aufirst=R&rft.date=1990-02-01&rft.volume=35&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-21 N1 - Date created - 1990-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of ethanol on polyamine synthesis during liver regeneration in rats. AN - 79597762; 2298913 AB - Ethanol consumption retards the hepatic regenerative response to injury. This may contribute to the pathogenesis of liver injury in alcoholic individuals. The mechanisms responsible for ethanol-associated inhibition of liver regeneration are poorly understood. To determine if the antiregenerative effects of ethanol involve modulation of polyamine metabolism, parameters of polyamine synthesis were compared before and during surgically induced liver regeneration in ethanol-fed rats and isocalorically maintained controls. After partial hepatectomy, induction of the activity of ornithine decarboxylase (ODC), the rate limiting enzyme for polyamine synthesis, was delayed in rats that had been fed ethanol. This was correlated with reduced levels of putrescine, ODC's immediate product. Increases in hepatic spermidine and spermine were also inhibited. Differences in ODC activity between ethanol-fed and control rats could not be explained by differences in the expression of ODC mRNA or by differences in ODC apoenzyme concentrations, suggesting that chronic ethanol intake inactivates ODC posttranslationally. Supplemental putrescine, administered at partial hepatectomy and 4 and 8 h thereafter, increased hepatic putrescine concentrations and markedly improved DNA synthesis and liver regeneration in ethanol-fed rats. These data suggest that altered polyamine metabolism may contribute to the inhibition of liver regeneration that occurs after chronic exposure to ethanol. JF - The Journal of clinical investigation AU - Diehl, A M AU - Wells, M AU - Brown, N D AU - Thorgeirsson, S S AU - Steer, C J AD - Department of Medicine, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 385 EP - 390 VL - 85 IS - 2 SN - 0021-9738, 0021-9738 KW - Biogenic Polyamines KW - 0 KW - Ornithine Decarboxylase Inhibitors KW - RNA, Messenger KW - Ethanol KW - 3K9958V90M KW - DNA KW - 9007-49-2 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Ornithine Decarboxylase -- genetics KW - Hepatectomy KW - RNA, Messenger -- analysis KW - Ornithine Decarboxylase -- analysis KW - DNA -- biosynthesis KW - Male KW - Liver Regeneration -- drug effects KW - Ethanol -- toxicity KW - Biogenic Polyamines -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79597762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Effect+of+ethanol+on+polyamine+synthesis+during+liver+regeneration+in+rats.&rft.au=Diehl%2C+A+M%3BWells%2C+M%3BBrown%2C+N+D%3BThorgeirsson%2C+S+S%3BSteer%2C+C+J&rft.aulast=Diehl&rft.aufirst=A&rft.date=1990-02-01&rft.volume=85&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-15 N1 - Date created - 1990-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1979 Sep;77(3):528-31 [572315] Med Clin North Am. 1979 May;63(3):479-93 [376968] Int J Artif Organs. 1979 Mar;2(2):49-52 [468393] Biochim Biophys Acta. 1979 Nov 1;587(4):556-66 [228751] Biochim Biophys Acta. 1980 Feb 29;606(2):338-46 [7357007] J Chromatogr. 1979 Sep 11;164(1):35-40 [541396] Q J Stud Alcohol. 1972 Mar;33(1):171-85 [4551020] Science. 1974 Mar 1;183(4127):817-24 [4359338] Proc Natl Acad Sci U S A. 1975 Oct;72(10):4042-5 [1060087] J Nutr. 1976 May;106(5):653-64 [4599] N Engl J Med. 1976 Dec 30;295(27):1517-9 [995158] Biochim Biophys Acta. 1978 Apr 6;473(3-4):241-93 [350276] FEBS Lett. 1980 May 5;113(2):211-4 [6104605] Anal Biochem. 1980 Mar 1;102(2):344-52 [6158890] Gut. 1980 May;21(5):423-7 [7429306] J Lab Clin Med. 1981 Feb;97(2):221-30 [7452093] Gut. 1982 Jan;23(1):8-13 [7056500] Biochim Biophys Acta. 1982 Feb 26;696(2):179-86 [6800405] Med Biol. 1981 Dec;59(5-6):381-8 [7339301] Alcohol Clin Exp Res. 1982 Winter;6(1):72-9 [7041688] Cell Tissue Kinet. 1982 Sep;15(5):521-8 [7127401] Fed Proc. 1982 Dec;41(14):3078-83 [7141003] Biochem J. 1982 Aug 15;206(2):311-8 [6816220] Int J Vitam Nutr Res. 1982;52(3):266-71 [7174224] Alcohol Clin Exp Res. 1982 Fall;6(4):523-31 [6758624] Hepatology. 1983 Jul-Aug;3(4):567-71 [6407956] Proc Natl Acad Sci U S A. 1984 Jan;81(2):540-4 [6582509] J Biol Chem. 1984 Jun 25;259(12):7941-6 [6330090] J Clin Invest. 1984 Sep;74(3):698-704 [6432848] Annu Rev Biochem. 1984;53:749-90 [6206782] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7338-42 [6095287] Biochem Biophys Res Commun. 1985 Apr 30;128(2):767-74 [3888219] Biosci Rep. 1985 Mar;5(3):189-204 [3893559] Drug Metab Rev. 1985;16(1-2):1-88 [3905315] J Biol Chem. 1985 Dec 15;260(29):15390-3 [3934157] Adv Enzyme Regul. 1985;23:311-29 [4072800] Gastroenterology. 1986 May;90(5 Pt 1):1261-7 [3082705] FEBS Lett. 1986 Sep 1;205(1):61-5 [3743770] J Biol Chem. 1986 Sep 15;261(26):12400-7 [3745194] Eur J Biochem. 1988 Mar 1;172(2):287-92 [2832159] Hepatology. 1988 Mar-Apr;8(2):237-42 [3356404] Mol Cell Biol. 1988 Jun;8(6):2504-12 [3043180] Proc Natl Acad Sci U S A. 1979 Jun;76(6):2541-5 [288043] J Lab Clin Med. 1979 Mar;93(3):402-13 [429851] Lab Invest. 1959 Nov-Dec;8:1547-62 [14419329] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Deoxycorticosterone hypertension in the intact weanling rat without salt loading. AN - 79597140; 2298466 AB - Deoxycorticosterone (DOC) hypertension in the rat is generally induced in rats at an age of approximately 3 months. Both uninephrectomy and a high sodium diet are necessary, however, to induce DOC hypertension. Considering the inability of the developing kidney to adequately excrete a sodium load, we studied the possibility that DOC alone might induce hypertension when treatment is initiated in rats at the age of 21 days. The contribution of volume expansion as a factor mediating the pressor response to DOC was assessed in rats given a high sodium diet instead of DOC. Systolic blood pressure increased in DOC-treated rats within 3 weeks. Although systolic blood pressure also increased in rats on a high sodium diet, the increase was transient and of a lesser magnitude than that observed in DOC-treated rats. The rise in blood pressure in both groups of rats was associated with suppression of plasma renin activity and aldosterone concentration. Furthermore, extracellular fluid volume was similarly increased in DOC-treated rats and rats given a high sodium diet. Consistent with these data, DOC-treated rats showed an exaggerated natriuretic response to acute saline loading as compared with a vehicle-treated control group. Discontinuation of DOC treatment after 5 weeks led to normalization of all variables studied including blood pressure. Yet, when DOC was continued for 8 weeks, stopping treatment did not lower blood pressure despite normalization of the renin-angiotensin-aldosterone system and the natriuretic response to saline loading. In contrast, discontinuation of the high sodium diet after 8 weeks normalized blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hypertension (Dallas, Tex. : 1979) AU - Rodriguez-Sargent, C AU - Torres-Negron, I AU - Cangiano, J L AU - Martinez-Maldonado, M AD - Veterans Administration Hospital, San Juan, Puerto Rico 00927-5800. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - I112 EP - I116 VL - 15 IS - 2 Suppl SN - 0194-911X, 0194-911X KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Aging -- physiology KW - Animals KW - Blood Pressure KW - Sodium Chloride -- administration & dosage KW - Natriuresis KW - Diet KW - Time Factors KW - Hypertension -- urine KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79597140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Deoxycorticosterone+hypertension+in+the+intact+weanling+rat+without+salt+loading.&rft.au=Rodriguez-Sargent%2C+C%3BTorres-Negron%2C+I%3BCangiano%2C+J+L%3BMartinez-Maldonado%2C+M&rft.aulast=Rodriguez-Sargent&rft.aufirst=C&rft.date=1990-02-01&rft.volume=15&rft.issue=2+Suppl&rft.spage=I112&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-13 N1 - Date created - 1990-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of amino acids in HLA-DPw4b beta and -DR5 beta 1 chains that are involved in antibody binding epitopes using site-directed mutagenesis and DNA-mediated gene transfer. AN - 79595545; 1688836 AB - Based on comparisons of the amino acid sequences of the beta chains of HLA class II molecules that do or do not bind the I-LR1 monoclonal antibody, we predicted that glutamic acid 56 of I-LR1-positive DPw2, DPw3, and DPw4b beta chains and the analogous glutamic acid 58 of I-LR1-positive DR5 beta 1 chains are involved in the I-LR1 epitope. Site-directed mutagenesis of DPw4b beta and DR5 beta 1 cDNAs was used to change the codons for glutamic acid 56 in DPw4b beta and glutamic acid 58 in DR5 beta 1 to the codon for alanine found in I-LR1-negative beta chains. Transfectants expressing wild-type DPw4b beta chains or DR5 beta 1 chains bind the I-LR1 monoclonal antibody, whereas transfectants expressing the mutant DPw4b beta or DR5 beta 1 chains do not bind I-LR1. Therefore, DPw4b beta glutamic acid 56 and DR5 beta 1 glutamic acid 58 are involved in the epitope recognized by the I-LR1 monoclonal antibody. Interestingly, the DR5 beta 1 glutamic acid----alanine 58 substitution also causes the loss of binding of two DR5-specific monoclonal antibodies to DR5 beta 1 molecules. Because the sequences of amino acids 36 to 64 of the DPw4b beta chain and 38 to 66 of the DR5 beta 1 chain are identical, these data raise some interesting issues about the formation of antibody epitopes on class II molecules. JF - Human immunology AU - Yu, W Y AU - Watts, R AU - Karr, R W AD - Veterans Administration Medical Center, Iowa City, IA 52246. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 122 EP - 135 VL - 27 IS - 2 SN - 0198-8859, 0198-8859 KW - Antibodies, Monoclonal KW - 0 KW - Epitopes KW - HLA-DP Antigens KW - HLA-DP beta-Chains KW - HLA-DPw4 antigen KW - HLA-DR5 Antigen KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Transfection KW - Humans KW - DNA -- genetics KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Molecular Conformation KW - Mutation KW - Binding Sites KW - HLA-DP Antigens -- genetics KW - HLA-DR5 Antigen -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79595545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+immunology&rft.atitle=Identification+of+amino+acids+in+HLA-DPw4b+beta+and+-DR5+beta+1+chains+that+are+involved+in+antibody+binding+epitopes+using+site-directed+mutagenesis+and+DNA-mediated+gene+transfer.&rft.au=Yu%2C+W+Y%3BWatts%2C+R%3BKarr%2C+R+W&rft.aulast=Yu&rft.aufirst=W&rft.date=1990-02-01&rft.volume=27&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Human+immunology&rft.issn=01988859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-12 N1 - Date created - 1990-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Binding of platelet activating factor by isolated membranes from U937 cells. AN - 79593873; 2153465 AB - Platelet activating factor (PAF), 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (1-O-alkyl-2-acetyl-GPC) has been known to have biological effect on cells. The mechanisms of the effect of the potent phospholipid on cells has not been established. We have used 1-O-[3H]alkyl-2-acetyl-GPC [( 3H]PAF) to study the interaction on the isolated membranes of U937 cells. The binding process was time, protein concentration, temperature dependent and reversible. The binding of [3H]PAF to the U937 cell membranes was slightly inhibited by the addition of PAF analogue, 3-O-Hexadecyl-2-acetyl-sn-glycerol-1-phosphorylcholine. U937 cell membranes showed high affinity binding sites for PAF with equilibrium dissociation constant (Kd) of 5 x 10(-9) M. The displacement of bound [3H]PAF with 500-fold excess of nonlabeled PAF was not altered suggesting that the bound [3H]PAF was not degraded during the binding. Binding of [3H]PAF on U937 cell membranes was inhibited by PAF antagonist, 59227RP. The kinetic of the inhibition by PAF antagonist is competitive suggesting that PAF and PAF antagonist bind at the same site. JF - Cellular immunology AU - Lee, J S AU - Ong, R AU - Yoo, T J AU - Chiang, T AD - Veterans Administration Medical Center, Department of Medicine, Memphis, Tennessee. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 415 EP - 425 VL - 125 IS - 2 SN - 0008-8749, 0008-8749 KW - Phorbol Esters KW - 0 KW - Platelet Activating Factor KW - Platelet Membrane Glycoproteins KW - Receptors, Cell Surface KW - Receptors, G-Protein-Coupled KW - platelet activating factor receptor KW - Peptide Hydrolases KW - EC 3.4.- KW - Index Medicus KW - Phorbol Esters -- pharmacology KW - Peptide Hydrolases -- pharmacology KW - Humans KW - Cell Membrane -- metabolism KW - Cell Line KW - Platelet Activating Factor -- antagonists & inhibitors KW - Platelet Activating Factor -- metabolism KW - Receptors, Cell Surface -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79593873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Binding+of+platelet+activating+factor+by+isolated+membranes+from+U937+cells.&rft.au=Lee%2C+J+S%3BOng%2C+R%3BYoo%2C+T+J%3BChiang%2C+T&rft.aulast=Lee&rft.aufirst=J&rft.date=1990-02-01&rft.volume=125&rft.issue=2&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of TGF beta gene expression in rat liver intoxicated with carbon tetrachloride. AN - 79590652; 2298342 AB - Transforming growth factor beta (TGF beta) has been implicated as having a central role in the postinflammatory tissue regeneration and fibrosis. To test its potential involvement in events that follow hepatotoxin-mediated liver regeneration and fibrosis, we quantitated changes in the steady-state levels of TGF beta mRNA in parenchymal and nonparenchymal cells at various times after an acute treatment with CCl4, and also compared TGF beta gene expression in these two cell types from livers subjected to chronic CCl4 treatment. The parenchymal and nonparenchymal cells from normal liver contained undetectable amounts of TGF beta mRNA. In contrast, we could readily detect TGF beta specific transcripts in both the parenchymal and nonparenchymal cells after acute injury. Nonparenchymal cells from acutely injured liver contained fivefold greater amounts of TGF beta mRNA, which peaked at 48 h and declined thereafter. In chronically treated rat livers (1, 2, 3, and 7 wk after the initiation of CCl4 treatment), increased expression of TGF beta mRNA was found only in nonparenchymal cells obtained after 2-3 wk of treatment. Strikingly large elevations in the steady-state levels of beta-actin mRNA in CCl4-treated liver were also observed, which may be related to the known regenerative processes associated with acute liver toxicity. Changing dynamics of TGF beta gene expression, therefore, appear to be an important attribute of regenerating liver after acute or chronic CCl4 toxicity. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Armendariz-Borunda, J AU - Seyer, J M AU - Kang, A H AU - Raghow, R AD - Veterans Administration Medical Center, Memphis, Tennessee 38104. Y1 - 1990/02/01/ PY - 1990 DA - 1990 Feb 01 SP - 215 EP - 221 VL - 4 IS - 2 SN - 0892-6638, 0892-6638 KW - Actins KW - 0 KW - DNA Probes KW - RNA, Messenger KW - Transforming Growth Factors KW - 76057-06-2 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Actins -- genetics KW - Nucleic Acid Hybridization KW - RNA, Messenger -- biosynthesis KW - Male KW - Liver Cirrhosis, Experimental -- chemically induced KW - Liver -- metabolism KW - Liver Cirrhosis, Experimental -- metabolism KW - Gene Expression Regulation KW - Liver Regeneration -- physiology KW - Carbon Tetrachloride -- toxicity KW - Transforming Growth Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79590652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Regulation+of+TGF+beta+gene+expression+in+rat+liver+intoxicated+with+carbon+tetrachloride.&rft.au=Armendariz-Borunda%2C+J%3BSeyer%2C+J+M%3BKang%2C+A+H%3BRaghow%2C+R&rft.aulast=Armendariz-Borunda&rft.aufirst=J&rft.date=1990-02-01&rft.volume=4&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Clinical and neuropsychological significance. AN - 85254379; pmid-2294856 AB - Magnetic resonance imaging was utilized to determine the nature and rate of subcortical abnormalities in bipolar affective disorder. Nine of 19 bipolar patients and no controls demonstrated subcortical signal hyperintensities on blind evaluation of the images. There was no apparent change in the appearance of the hyperintensities in 7 of 7 subjects with abnormal magnetic resonance images who underwent repeated imaging at 1 year. Bipolar patients with abnormalities had a history of more hospitalizations and appeared more impaired on tests of fluency and recall when compared with bipolar patients without abnormalities or with controls. The possible etiology and significance of signal hyperintensities in bipolar affective disorder is discussed. JF - Archives of General Psychiatry AU - Dupont, R M AU - Jernigan, T L AU - Butters, N AU - Delis, D AU - Hesselink, J R AU - Heindel, W AU - Gillin, J C AD - San Diego Veterans Administration Medical Center, CA. PY - 1990 SP - 55 EP - 59 VL - 47 IS - 1 SN - 0003-990X, 0003-990X KW - Language Tests KW - Support, U.S. Gov't, P.H.S. KW - Diagnosis, Differential KW - Bipolar Disorder KW - Human KW - Brain KW - Basal Ganglia KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Follow-Up Studies KW - Neuropsychological Tests KW - Male KW - Female KW - Biological Markers KW - Magnetic Resonance Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85254379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Subcortical+abnormalities+detected+in+bipolar+affective+disorder+using+magnetic+resonance+imaging.+Clinical+and+neuropsychological+significance.&rft.au=Dupont%2C+R+M%3BJernigan%2C+T+L%3BButters%2C+N%3BDelis%2C+D%3BHesselink%2C+J+R%3BHeindel%2C+W%3BGillin%2C+J+C&rft.aulast=Dupont&rft.aufirst=R&rft.date=1990-01-01&rft.volume=47&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Archives+of+General+Psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Association between hearing impairment and the quality of life of elderly individuals. AN - 85238888; pmid-2295767 AB - Hearing impairment is one of the most common chronic health problems of elderly Americans. Although adverse effects on quality of life are thought to be considerable, they have not been rigorously evaluated. This study was designed to identify the types and extent of dysfunction experienced by elderly individuals with hearing loss, and to define the most appropriate measures for assessing this dysfunction. Elderly male veterans attending a primary care clinic were screened for hearing loss and had their quality of life assessed with a comprehensive battery of disease-specific and generic measures. Of 472 people who had their hearing tested, 106 had hearing loss. Hearing loss was associated with significant emotional (P = .0001), social (P = .0001), and communication (P = .02) dysfunction. Most individuals (66%) perceived these dysfunctions as severe handicaps even though audiologic loss revealed only mild to moderate impairment (pure tone average loss, 27-55 dB). Adverse effects were best detected with disease-specific rather than generic functional status measures. We conclude that hearing impairment is associated with important adverse effects on the quality of life of elderly individuals, and that these effects are perceived as severe handicaps even by individuals with only mild to moderate degrees of hearing loss. JF - Journal of the American Geriatrics Society AU - Mulrow, C D AU - Aguilar, C AU - Endicott, J E AU - Velez, R AU - Tuley, M R AU - Charlip, W S AU - Hill, J A AD - Division of General Internal Medicine, Audie L. Murphy Veterans' Administration Hospital, San Antonio, Texas 78248. PY - 1990 SP - 45 EP - 50 VL - 38 IS - 1 SN - 0002-8614, 0002-8614 KW - Cross-Sectional Studies KW - Hearing Disorders KW - Aged, 80 and over KW - Random Allocation KW - Human KW - Support, Non-U.S. Gov't KW - Aged KW - Activities of Daily Living KW - Social Isolation KW - Neuropsychological Tests KW - Affective Symptoms KW - Male KW - Communication Disorders KW - Quality of Life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85238888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Association+between+hearing+impairment+and+the+quality+of+life+of+elderly+individuals.&rft.au=Mulrow%2C+C+D%3BAguilar%2C+C%3BEndicott%2C+J+E%3BVelez%2C+R%3BTuley%2C+M+R%3BCharlip%2C+W+S%3BHill%2C+J+A&rft.aulast=Mulrow&rft.aufirst=C&rft.date=1990-01-01&rft.volume=38&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Serial processing of visual spatial patterns in a search paradigm. AN - 85209773; pmid-2297433 AB - Previous experiments in this laboratory employing a search paradigm have found highly significant differences in the detectability of a briefly exposed target pattern as a function of the spatial location of the target when it is presented simultaneously with a number of discriminably different nontarget patterns. These detectability differences, at loci equidistant from the fovea, could not be accounted for by any known variation in retinal spatial resolution or by differential lateral masking effects of the target by nearby nontarget patterns. These observations led to the hypothesis that the target in these experiments was detected by a serial mechanism which "scanned" a persisting but rapidly degrading neural representation of the visual scene with increasing detection failures the later in time the scan processed the location occupied by the target. If this hypothesis is correct, then target detectability should vary inversely with the number of stimuli which must be examined. The present experiment confirmed this expectation. A mathematical model of such a serial scanning process also predicts other, less obvious, effects on target detectability which were observed when the number of nontarget patterns was changed. JF - Brain and Cognition AU - Efron, R AU - Yund, E W AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 17 EP - 41 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Visual Fields KW - Male KW - Female KW - Reaction Time KW - Discrimination Learning KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Serial Learning KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Serial+processing+of+visual+spatial+patterns+in+a+search+paradigm.&rft.au=Efron%2C+R%3BYund%2C+E+W%3BNichols%2C+D+R&rft.aulast=Efron&rft.aufirst=R&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visual detectability gradients: the effect of distractors in contralateral field. AN - 85209576; pmid-2297430 AB - A number of studies involving recognition of tachistoscopically presented words have reported that the typical right visual field performance superiority associated with linguistic stimuli is enhanced by bilateral presentations (simultaneous stimuli in both visual half-fields) compared to unilateral presentations (stimuli in only one half-field on a trial). We have reported the same phenomenon, however, using visual spatial patterns in a search paradigm (E. W. Yund, R. Efron, & D. R. Nichols, 1990c. Brain and Cognition, 12, 117-127) and have accounted for it in terms of the operating characteristics of a visual scanning mechanism which serially examines a decaying neural representation of the stimuli. In the present experiment we attempted to exploit these operating characteristics to influence this difference between unilateral and bilateral presentations. The results not only are consistent with the assumptions of the scanning hypothesis but they also provide new information pertinent to the operating characteristics of this mechanism. JF - Brain and Cognition AU - Efron, R AU - Yund, E W AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 128 EP - 143 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Discrimination Learning KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Laterality KW - Visual Fields KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Dominance, Cerebral KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Visual+detectability+gradients%3A+the+effect+of+distractors+in+contralateral+field.&rft.au=Efron%2C+R%3BYund%2C+E+W%3BNichols%2C+D+R&rft.aulast=Efron&rft.aufirst=R&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Detectability gradients as a function of target location. AN - 85209542; pmid-2297427 AB - We examined the ability to detect a specified visual pattern (a target) in a randomly selected location when it was briefly presented with 11 other spatially distributed nontarget patterns and also when it was presented by itself for the same duration (50 msec) on a background of visual noise. Two experiments were designed to measure target detectability as a function of its location in the visual field where all possible target locations were equidistant from the fovea. A right visual field detection superiority was obtained in both experiments. In addition, highly significant detectability differences were observed within the right and left visual fields in both experiments. The origin of these detectability differences are interpreted in terms of parallel and serial processing mechanisms. JF - Brain and Cognition AU - Yund, E W AU - Efron, R AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 1 EP - 16 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Reference Values KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Visual Fields KW - Female KW - Male KW - Discrimination Learning KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Detectability+gradients+as+a+function+of+target+location.&rft.au=Yund%2C+E+W%3BEfron%2C+R%3BNichols%2C+D+R&rft.aulast=Yund&rft.aufirst=E&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Detectability as a function of spatial location: effects of selective attention. AN - 85209497; pmid-2297434 AB - In a series of previous reports we have described differences in detectability of a target in a background of nontarget patterns as a function of its spatial location. These differences, referred to as a "detectability gradient," have been attributed to target detection accomplished by a serial processing mechanism--a scan. The mathematical model of such a mechanism, developed in the previous report, is equally applicable to a series of attentional shifts or to a perceptual, i.e., a preattentive, mechanism. The present experiments were designed to test the hypothesis that this scan is attentional in nature. The results provide additional evidence for the scanning hypothesis but do not support the view that this scan represents a series of attentional shifts. JF - Brain and Cognition AU - Yund, E W AU - Efron, R AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 42 EP - 54 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Probability Learning KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Serial Learning KW - Visual Fields KW - Male KW - Female KW - Discrimination Learning KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Detectability+as+a+function+of+spatial+location%3A+effects+of+selective+attention.&rft.au=Yund%2C+E+W%3BEfron%2C+R%3BNichols%2C+D+R&rft.aulast=Yund&rft.aufirst=E&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Detectability as a function of target location: effects of spatial configuration. AN - 85209455; pmid-2297428 AB - Marked differences in detectability as a function of spatial location, a "detectability gradient," are observed when subjects are required to detect a briefly exposed target pattern of uncertain location in the presence of a number of nontarget patterns. Target detectability also is inversely related to the number of nontarget patterns which are present in this search paradigm. These previous findings provide strong evidence for a serial process in which increasing probability of error occurs during a scan of a rapidly degrading neural representation of the visual image following a brief exposure to the stimuli. It is not yet established whether this scan is attentional or perceptual in nature. The present experiments test the hypothesis of an attentional scan by presenting the target and nontarget patterns in spatially segregated groups. If the scan is attentional, then target detectability under these circumstances would be expected to exhibit the characteristic phenomenon of "group processing"--a close clustering of detection performance for targets located within a group and large differences in detectability across groups. As no evidence for group processing was observed, the results fail to support the view that the scan is attentional in nature but are fully consistent with a nonattentional scan. JF - Brain and Cognition AU - Efron, R AU - Yund, E W AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 102 EP - 116 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Eye Movements KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Visual Fields KW - Male KW - Female KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Space Perception KW - Dominance, Cerebral KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Detectability+as+a+function+of+target+location%3A+effects+of+spatial+configuration.&rft.au=Efron%2C+R%3BYund%2C+E+W%3BNichols%2C+D+R&rft.aulast=Efron&rft.aufirst=R&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Target detection in one visual field in the presence or absence of stimuli in the contralateral field by right- and left-handed subjects. AN - 85208712; pmid-2297429 AB - Marked differences in detectability are observed as a function of retinal locus when subjects are required to find a briefly exposed target pattern of uncertain location in the presence of a number of discriminably different nontarget patterns. Our previous studies using this search paradigm have attributed these detectability differences, and the right visual field detectability superiority associated with them, to a serial (scanning) mechanism which tends to examine stimuli in the right field earlier than those in the left. The present experiment, performed on large groups of right- and left-handed subjects, was designed to test the hypothesis that there are two independent serial processors, one in each hemisphere--an hypothesis which might account for the differences in detectability within and between the two half-fields in terms of hemispheric processing differences. The results are inconsistent with the dual independent serial processor hypothesis but are fully consistent with a single serial processor, a scanning mechanism, which has access to the information presented to both visual half-fields. JF - Brain and Cognition AU - Yund, E W AU - Efron, R AU - Nichols, D R AD - Neurophysiology-Biophysics Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. PY - 1990 SP - 117 EP - 127 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Discrimination Learning KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Psychomotor Performance KW - Serial Learning KW - Male KW - Female KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Laterality KW - Dominance, Cerebral KW - Attention KW - Visual Fields UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Target+detection+in+one+visual+field+in+the+presence+or+absence+of+stimuli+in+the+contralateral+field+by+right-+and+left-handed+subjects.&rft.au=Yund%2C+E+W%3BEfron%2C+R%3BNichols%2C+D+R&rft.aulast=Yund&rft.aufirst=E&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Beyond scripts: a note on the capacity of right hemisphere-damaged patients to process social and emotional content. AN - 85208417; pmid-2297431 AB - Individuals with right hemisphere damage (RHD) can comprehend simple scripts but have difficulties understanding more complex forms of discourse such as stories and jokes. This study sought to discover the point beyond simple scripts at which such patients begin to experience difficulties. Three-sentence, script-like vignettes which described everyday situations were created along two major dimensions: a social dimension (reflecting presence or absence of interactions between characters); and an emotional dimension (reflecting a positive, negative, or neutral emotion felt by a protagonist in the situation). Right hemisphere-damaged patients were asked to provide emotional characterizations of, and continuations to, these situational vignettes. Results indicated that individuals with right hemisphere damage were more likely than control subjects to attribute a positive emotional state to a character in a neutral situation. In other respects, there were no significant differences between RHD subjects and controls, although the RHD subjects made significantly more factual errors in their continuations than did control subjects. JF - Brain and Cognition AU - Ostrove J M AU - Simpson, T AU - Gardner, H AD - Boston Veterans Administration Medical Center 02130. PY - 1990 SP - 144 EP - 154 VL - 12 IS - 1 SN - 0278-2626, 0278-2626 KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Adult KW - Brain Damage, Chronic KW - Support, Non-U.S. Gov't KW - Role KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Aged KW - Male KW - Female KW - Social Environment KW - Emotions KW - Interpersonal Relations KW - Dominance, Cerebral UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Beyond+scripts%3A+a+note+on+the+capacity+of+right+hemisphere-damaged+patients+to+process+social+and+emotional+content.&rft.au=Ostrove+J+M%3BSimpson%2C+T%3BGardner%2C+H&rft.aulast=Ostrove+J+M&rft.aufirst=&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Pathogenesis and therapy of peptic ulcer disease. AN - 85200805; pmid-1978840 AB - The epithelial cells of the stomach and duodenum are normally protected from the damaging effects of acid and pepsin by a balancing mechanism of mucosal resistance. If an imbalance occurs, peptic ulcer may result. Traditional teaching has emphasized the importance of acid (and pepsin) as the cause of this imbalance; however, it is clear that acid and pepsin are not the only important factors in the pathogenesis of peptic ulcer. More recent investigative efforts have been directed at what constitutes mucosal resistance and how it can be disrupted to produce, in the presence of gastric acid, a peptic ulcer. Depletion of endogenous prostaglandins and Helicobacter pylori gastritis have emerged as prominent theories. As evidence exists both to support and refute these theories in humans, any definitive conclusions cannot be made at this time. The acute management of peptic ulcer disease is directed at relieving pain, accelerating ulcer healing, and preventing complications. Peptic ulcers can be healed with antisecretory agents (i.e., H2-receptor antagonists, omeprazole), antacids, prostaglandins, and sucralfate. Because they are effective, safe, and convenient, the H2-receptor antagonists are the most widely used agents for the management of peptic ulcer disease. Because the H2-receptor antagonist agents are equally effective in their indicated uses and are equally safe based on scientifically valid data, selection should be based primarily on cost. Omeprazole is the newest antisecretory agent: a single morning dose of 20 mg suppresses acid secretion for 24 h. The agent offers little advantage over H2-receptor antagonists for the majority of patients with peptic ulcer.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of Clinical Gastroenterology AU - Peterson, W L AD - Medical Service, Veterans Administration Medical Center, Dallas, TX 75216. PY - 1990 SP - S1 EP - S6 VL - 12 Suppl 2 SN - 0192-0790, 0192-0790 KW - Sucralfate KW - Human KW - Anti-Ulcer Agents KW - Prostaglandins KW - Antacids KW - Antibiotics KW - Histamine H2 Antagonists KW - Bismuth KW - Peptic Ulcer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85200805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Pathogenesis+and+therapy+of+peptic+ulcer+disease.&rft.au=Peterson%2C+W+L&rft.aulast=Peterson&rft.aufirst=W&rft.date=1990-01-01&rft.volume=12+Suppl+2&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - NSAID-induced gastrointestinal damage. A critical review of prophylaxis and therapy. AN - 85198110; pmid-1978842 AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) cause acute diffuse injury to the gastroduodenal mucosa, and also cause chronic focal ulcers that may bleed or perforate without warning symptoms. Acute and chronic lesions are distinct, are pathogenetically different, respond differently to drugs, and require different management strategies. The principal rationale for antiulcer therapy in NSAID users is to prevent or reduce potentially fatal outcomes; to date no evaluated drug meets this criterion for efficacy. Antacids and H2-receptor antagonists, based on open uncontrolled studies, appear to heal both gastric and duodenal ulcers, and maintain them healed during continued NSAID use; larger gastric ulcers show delayed healing with conventional doses of H2-receptor antagonists during NSAID therapy. No such delay occurs with omeprazole therapy. The suggests that if NSAID-associated gastric ulcers are treated with H2-receptor antagonists, larger doses should be given for longer periods. In patients with no pre-existing ulcer disease, H2-receptor antagonists given prophylactically prevent duodenal but not gastric ulcers; sucralfate does the same. In individuals without peptic ulcer disease taking NSAIDs, misoprostol, given as prophylaxis, reduces the development of gastric ulcers; its beneficial effects on ulcer healing or symptoms during continued NSAID therapy, or its ability to prevent duodenal ulcers or ulcer complications, are not established. Because of diarrhea, the 400 micrograms/day dosage is recommended, especially in the elderly. JF - Journal of Clinical Gastroenterology AU - McCarthy, D M AD - Division of Gastroenterology, Veterans Administration Medical Center, Albuquerque, New Mexico 87108. PY - 1990 SP - S13 EP - S20 VL - 12 Suppl 2 SN - 0192-0790, 0192-0790 KW - Human KW - Anti-Ulcer Agents KW - Prostaglandins KW - Anti-Inflammatory Agents, Non-Steroidal KW - Histamine H2 Antagonists KW - Intestinal Perforation KW - Peptic Ulcer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85198110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=NSAID-induced+gastrointestinal+damage.+A+critical+review+of+prophylaxis+and+therapy.&rft.au=McCarthy%2C+D+M&rft.aulast=McCarthy&rft.aufirst=D&rft.date=1990-01-01&rft.volume=12+Suppl+2&rft.issue=&rft.spage=S13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Granulocyte storage. AN - 80399586; 2134614 JF - Transfusion medicine reviews AU - Lane, T A AD - Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 23 EP - 34 VL - 4 IS - 1 SN - 0887-7963, 0887-7963 KW - Cryoprotective Agents KW - 0 KW - Index Medicus KW - Infection -- etiology KW - Cytotoxicity, Immunologic KW - Cryoprotective Agents -- pharmacology KW - Humans KW - Temperature KW - Cytotoxicity Tests, Immunologic KW - Disease Susceptibility -- immunology KW - Phagocytosis KW - Chemotaxis, Leukocyte KW - Cryopreservation KW - Cell Survival KW - Granulocytes -- transplantation KW - Blood Preservation -- methods KW - Granulocytes -- physiology KW - Blood Component Transfusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80399586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion+medicine+reviews&rft.atitle=Granulocyte+storage.&rft.au=Lane%2C+T+A&rft.aulast=Lane&rft.aufirst=T&rft.date=1990-01-01&rft.volume=4&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Transfusion+medicine+reviews&rft.issn=08877963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-30 N1 - Date created - 1992-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specificity of conditional responding to naturalistic stimuli in humans with different drug-use histories. AN - 80384216; 1876010 JF - NIDA research monograph AU - Ehrman, R N AU - Robbins, S J AU - MacRae, J R AU - Childress, A R AD - Veterans Administration Medical Center, Philadelphia, PA. Y1 - 1990 PY - 1990 DA - 1990 SP - 282 EP - 283 VL - 105 SN - 1046-9516, 1046-9516 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Environment KW - Humans KW - Cues KW - Substance-Related Disorders -- psychology KW - Conditioning (Psychology) -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80384216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Specificity+of+conditional+responding+to+naturalistic+stimuli+in+humans+with+different+drug-use+histories.&rft.au=Ehrman%2C+R+N%3BRobbins%2C+S+J%3BMacRae%2C+J+R%3BChildress%2C+A+R&rft.aulast=Ehrman&rft.aufirst=R&rft.date=1990-01-01&rft.volume=105&rft.issue=&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-20 N1 - Date created - 1991-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of Psychopathy Checklist with opiate addicts. AN - 80381558; 1876135 JF - NIDA research monograph AU - Cacciola, J S AU - Rutherford, M AU - Alterman, A I AD - Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1990 PY - 1990 DA - 1990 SP - 597 EP - 598 VL - 105 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- psychology KW - Male KW - Opioid-Related Disorders -- psychology KW - Psychopathology -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80381558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Use+of+Psychopathy+Checklist+with+opiate+addicts.&rft.au=Cacciola%2C+J+S%3BRutherford%2C+M%3BAlterman%2C+A+I&rft.aulast=Cacciola&rft.aufirst=J&rft.date=1990-01-01&rft.volume=105&rft.issue=&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-20 N1 - Date created - 1991-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intraperitoneal injection induces prostaglandin-mediated protection from bile acid intestinal mucosal injury in rats in vivo. AN - 80345299; 2097182 AB - The production of endogenous prostaglandins by the gastrointestinal mucosa can be induced by many processes. Whether the commonly used technique of intraperitoneal injection alone can also induce significant endogenous prostaglandin-mediated mucosal injury induced in vivo by perfusion for 45 min with 5 mM chenodeoxycholic acid. 10 control rats received 1 ml/kg of normal saline subcutaneously on abdomen tree hours before exposure to chenodeoxycholic acid. Another group of 10 rats received 1 ml/kg of saline intraperitoneally before injury. Mucosal injury was assessed histologically by measuring villus tip epithelial cell denudation by computerized quantitative morphology. Injury was assessed functionally by measuring water and mannitol absorption from the lumen. To examine the role of endogenous prostaglandins in this phenomenon, the above experiment was repeated with 10 and 12 rats respectively by replacing the saline with 10 mg/kg injections of indomethacin. Intraperitoneal injection of saline reduced the average denudation/villus caused by chenodeoxycholic acid: Subcutaneous = 100.8 microns +/- 14.7 (SEM). Intraperitoneal = 65.1 +/- 6.4 (p less than 0.5). Parallel reductions were noted in the increase in water secretion and mannitol absorption caused by chenodeoxycholic acid. All of these differences were reversed by exchanging indomethacin for saline. This study suggests there exists a mechanism by which the simple act of performing an intraperitoneal injection induces endogenous intestinal mucosal protection. That this protection is negated by pretreatment with indomethacin suggests it is prostaglandin mediated. JF - Folia histochemica et cytobiologica AU - Erickson, R A AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Y1 - 1990 PY - 1990 DA - 1990 SP - 43 EP - 50 VL - 28 IS - 1-2 SN - 0239-8508, 0239-8508 KW - Prostaglandins KW - 0 KW - Chenodeoxycholic Acid KW - 0GEI24LG0J KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Perfusion KW - Intestine, Small -- drug effects KW - Intestine, Small -- pathology KW - Epithelium -- pathology KW - Male KW - Epithelium -- drug effects KW - Intestinal Mucosa -- cytology KW - Prostaglandins -- physiology KW - Chenodeoxycholic Acid -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - Indomethacin -- administration & dosage KW - Indomethacin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80345299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Folia+histochemica+et+cytobiologica&rft.atitle=Intraperitoneal+injection+induces+prostaglandin-mediated+protection+from+bile+acid+intestinal+mucosal+injury+in+rats+in+vivo.&rft.au=Erickson%2C+R+A&rft.aulast=Erickson&rft.aufirst=R&rft.date=1990-01-01&rft.volume=28&rft.issue=1-2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Folia+histochemica+et+cytobiologica&rft.issn=02398508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-22 N1 - Date created - 1991-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of aromatic and heterocyclic amine bladder carcinogens: bioanalytical considerations. AN - 80339893; 2128813 AB - Aromatic and heterocyclic amines are environmental chemicals which can cause bladder cancer in man. Because these chemicals cause carcinomas at a site distal to their portals of entry, metabolic processes are involved in initiation of their carcinogenic effects. N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and its deformylated analogue, ANFT, were used as model compounds to assess metabolism. Electrochemical properties of ANFT made liquid chromatography with electrochemical detection a specific and sensitive method for analysis. Peroxidatic metabolism of ANFT by prostaglandin H synthase (PHS) in the presence of N-acetylcysteine resulted in the formation of 2-amino-4-(5-nitro-2-furyl)-5-(N-acetylcystein-S-yl)thiazole (ANFT-MA). This thioether product has an oxidation potential significantly lower than ANFT. Rat urinary excretion of ANFT-MA was significantly decreased with peroxidase inhibitors, 6-n-propyl-2-thiouracil and methimazole. Inhibitors did not alter excretion of ANFT or prostaglandin E2, a PHS product of arachidonic acid metabolism. 1H and 13C-NMR were selected to explore potential structural differences between ANFT and FANFT which might explain preferential PHS metabolism of ANFT. Evidence for a "zwitterion" configuration for ANFT but not FANFT was observed. ANFT in the "zwitterion" configuration would be a better reducing co-substrate. Chemical synthesis and GC-MS fragmentation patterns identified 3-(2,3-dihydro-1-methyl-2-pyrrolyl)pyridine as a peroxidatic product of nicotine metabolism. This peroxidatic product was found in urine from a cigarette smoker in an amount approximately 6% that observed for continine. Thus, a potential rôle for peroxidative metabolism was demonstrated in man. JF - Journal of pharmaceutical and biomedical analysis AU - Mattammal, M B AU - Lakshmi, V M AU - Zenser, T V AU - Davis, B B AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125. Y1 - 1990 PY - 1990 DA - 1990 SP - 151 EP - 158 VL - 8 IS - 2 SN - 0731-7085, 0731-7085 KW - Carcinogens KW - 0 KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Index Medicus KW - Rats KW - Animals KW - Prostaglandin-Endoperoxide Synthases -- pharmacology KW - Electrochemistry KW - Chromatography, High Pressure Liquid KW - Carcinogens -- metabolism KW - FANFT -- analogs & derivatives KW - FANFT -- metabolism KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80339893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+and+biomedical+analysis&rft.atitle=Metabolism+of+aromatic+and+heterocyclic+amine+bladder+carcinogens%3A+bioanalytical+considerations.&rft.au=Mattammal%2C+M+B%3BLakshmi%2C+V+M%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Mattammal&rft.aufirst=M&rft.date=1990-01-01&rft.volume=8&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+and+biomedical+analysis&rft.issn=07317085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-03 N1 - Date created - 1991-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychotherapy and counseling for methadone-maintained opiate addicts: results of research studies. AN - 80337930; 2092228 AB - Data have been presented about the potential role of psychotherapy for psychiatrically impaired methadone-maintained opiate addicts. Complete data from one study, and preliminary data from a second, indicate that professional psychotherapy can be helpful as a supplement to ongoing drug-counseling services for patients having clinically significant psychiatric symptoms. If psychotherapy is to be used, care must be taken to integrate it into the ongoing clinical services of the methadone-treatment program. Not all therapists are equally adept at engaging and working with addicts. In hiring therapists, attempts should be made to identify those who are not only technically competent but also interested and comfortable with this population. It should also be emphasized that there is considerable variability among methadone programs in such vital areas as leadership, staffing patterns, organization, dosing procedures, location, physical plant, and availability of ancillary services. These administrative differences may play a significant role in the feasibility and success of attempts to use psychotherapy in drug-treatment programs. Finally, it should be noted that there is no evidence that psychotherapy cures addiction or that it can be used successfully without integrating it into other important services, such as drug counseling, methadone treatment, and the overall program structure. There is reason to believe, however, that it can provide additional and clinically meaningful benefits to that subgroup of methadone patients who are psychiatrically impaired. JF - NIDA research monograph AU - Woody, G E AU - McLellan, A T AU - Luborsky, L AU - O'Brien, C P AD - Substance Abuse Treatment Unit, Veterans' Administration Medical Center, Philadelphia, PA 11904. Y1 - 1990 PY - 1990 DA - 1990 SP - 9 EP - 23 VL - 104 SN - 1046-9516, 1046-9516 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Psychotherapy KW - Humans KW - Prognosis KW - Follow-Up Studies KW - Antisocial Personality Disorder -- etiology KW - Counseling KW - Community Health Services KW - Research Design KW - Male KW - Female KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Opioid-Related Disorders -- complications KW - Opioid-Related Disorders -- therapy KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80337930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Psychotherapy+and+counseling+for+methadone-maintained+opiate+addicts%3A+results+of+research+studies.&rft.au=Woody%2C+G+E%3BMcLellan%2C+A+T%3BLuborsky%2C+L%3BO%27Brien%2C+C+P&rft.aulast=Woody&rft.aufirst=G&rft.date=1990-01-01&rft.volume=104&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The long-term neurobehavioral consequences of substance abuse: conceptual and methodological challenges for future research. AN - 80337506; 2092209 JF - NIDA research monograph AU - Reed, R J AU - Grant, I AD - San Diego Veterans Administration Medical Center, San Diego. Y1 - 1990 PY - 1990 DA - 1990 SP - 10 EP - 56 VL - 101 SN - 1046-9516, 1046-9516 KW - Street Drugs KW - 0 KW - Index Medicus KW - Memory -- drug effects KW - Humans KW - Research KW - Behavior -- drug effects KW - Mental Disorders -- chemically induced KW - Substance-Related Disorders KW - Central Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80337506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+long-term+neurobehavioral+consequences+of+substance+abuse%3A+conceptual+and+methodological+challenges+for+future+research.&rft.au=Reed%2C+R+J%3BGrant%2C+I&rft.aulast=Reed&rft.aufirst=R&rft.date=1990-01-01&rft.volume=101&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-12 N1 - Date created - 1991-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of dietary selenium on the induction of altered hepatic foci and hepatic tumors by the peroxisome proliferator ciprofibrate. AN - 80307217; 2084622 AB - The purpose of this study was to determine if the dietary antioxidant selenium could inhibit hepatocarcinogenesis induced by peroxisome proliferators, which are hypothesized to induce tumors by increased production of hydrogen peroxide or other reactive oxygen species. Rats were fed diets containing the peroxisome proliferator ciprofibrate and one of three concentrations (0.04, 0.2, or 1.0 ppm) of selenium for 6 or 21 months. The incidence of hepatic tumors and the number and volume of gamma-glutamyl transpeptidase-positive, ATPase-negative, glucose-6-phosphatase-negative, and glucose-6-phosphatase-positive foci at 21 months were lower in rats fed higher levels of selenium (no foci or tumors were seen at 6 mo). Indices of oxidative damage in the liver (thiobarbituric acid reactants, conjugated dienes, and lipid-soluble fluorescence products), however, were not decreased in rats fed the high-selenium diet. Therefore, selenium was protective against ciprofibrate-induced hepatocarcinogenesis, but not by reducing the degree of oxidative damage. The liver selenium and glutathione concentrations, and liver selenium-dependent glutathione peroxidase activity, increased as dietary selenium increased. Therefore, inhibition of carcinogenesis by selenium was correlated with increased levels of glutathione and glutathione peroxidase, but these did not inhibit the indices of oxidative damage. Peroxisomal beta-oxidation also increased with the dietary selenium content; it therefore does not appear to be a factor in the inhibition of hepatocarcinogenesis in rats fed higher levels of selenium. JF - Nutrition and cancer AU - Glauert, H P AU - Beaty, M M AU - Clark, T D AU - Greenwell, W S AU - Chow, C K AD - Department of Nutrition and Food Science, Veterans Administration Hospital, University of Kentucky, Lexington 40506. Y1 - 1990 PY - 1990 DA - 1990 SP - 261 EP - 271 VL - 14 IS - 3-4 SN - 0163-5581, 0163-5581 KW - Fibric Acids KW - 0 KW - Clofibric Acid KW - 53PF01Q249 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - ciprofibrate KW - F8252JGO9S KW - Selenium KW - H6241UJ22B KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Analysis of Variance KW - Glutathione Peroxidase -- blood KW - Female KW - Clofibric Acid -- analogs & derivatives KW - Liver -- enzymology KW - Liver Neoplasms, Experimental -- metabolism KW - Liver -- drug effects KW - Selenium -- pharmacology KW - Liver Neoplasms, Experimental -- chemically induced KW - Liver -- metabolism KW - Selenium -- administration & dosage KW - Diet KW - Liver Neoplasms, Experimental -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80307217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+cancer&rft.atitle=Effect+of+dietary+selenium+on+the+induction+of+altered+hepatic+foci+and+hepatic+tumors+by+the+peroxisome+proliferator+ciprofibrate.&rft.au=Glauert%2C+H+P%3BBeaty%2C+M+M%3BClark%2C+T+D%3BGreenwell%2C+W+S%3BChow%2C+C+K&rft.aulast=Glauert&rft.aufirst=H&rft.date=1990-01-01&rft.volume=14&rft.issue=3-4&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+cancer&rft.issn=01635581&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-10 N1 - Date created - 1991-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Observer reliability in CT and MRI of the abdomen/pelvis. AN - 80302101; 2082127 AB - The purpose of this research was to evaluate two sources of error in the performance of computerized tomography (CT) and magnetic resonance imaging (MRI) of the abdomen/pelvis. The sources of error assessed were inter- and intra-observer reliability. Thirty abdomen/pelvis CT scans were randomly selected from each of three hospitals (university, VA, military) with different CT scanners. Two radiologists were recruited from each site to be CT observers. Forty-five abdomen/pelvis MRI scans were randomly selected from two institutions with different MRI scanners. Four observers were recruited to read the MRI scans. All scans were read blind without clinical information or patient identification. Overall inter-observer and intra-observer diagnostic agreement was significantly higher for MRI compared to CT. Inter-observer diagnostic agreement rates were also significantly higher for MRI when the etiologies of neoplastic vascular and metabolic/toxic were assigned. Observer experience in CT (range: 5-9 yr) or MRI (range: 2-4 yr) was not statistically associated with improved diagnostic agreement. This research addresses many of the criticisms of the MRI literature and compares MRI favorably to CT. JF - Magnetic resonance imaging AU - Reker, D M AU - Fletcher, J W AU - Tantana, S AU - Mahanta, B AU - Vas, W AU - Yoo, R AU - Gresick, R J AU - Romeis, J C AU - DuMontier, C C AU - Heiberg, E AD - Veterans Administration Medical Center, St. Louis, Missouri 63125. Y1 - 1990 PY - 1990 DA - 1990 SP - 577 EP - 582 VL - 8 IS - 5 SN - 0730-725X, 0730-725X KW - Index Medicus KW - Disease -- etiology KW - Hospitals, University KW - Diagnosis KW - Reproducibility of Results KW - Humans KW - Hospitals, Military KW - Observer Variation KW - Radiography, Abdominal KW - Hospitals, Veterans KW - Tomography, X-Ray Computed -- statistics & numerical data KW - Abdomen -- pathology KW - Pelvis -- diagnostic imaging KW - Magnetic Resonance Imaging -- statistics & numerical data KW - Pelvis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80302101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+resonance+imaging&rft.atitle=Observer+reliability+in+CT+and+MRI+of+the+abdomen%2Fpelvis.&rft.au=Reker%2C+D+M%3BFletcher%2C+J+W%3BTantana%2C+S%3BMahanta%2C+B%3BVas%2C+W%3BYoo%2C+R%3BGresick%2C+R+J%3BRomeis%2C+J+C%3BDuMontier%2C+C+C%3BHeiberg%2C+E&rft.aulast=Reker&rft.aufirst=D&rft.date=1990-01-01&rft.volume=8&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Magnetic+resonance+imaging&rft.issn=0730725X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-09 N1 - Date created - 1991-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential signal requirements in T-cell activation by mitogen and superantigen. AN - 80300297; 2081094 AB - The requirement for co-stimulatory molecules in T-cell stimulation by mitogens and superantigens in the absence of antigen-presenting cells (APC) was investigated. Phytohemagglutinin (PHA) induced interleukin (IL)-2 receptor (IL-2R) expression on purified T-cells, but proliferation occurred only when exogenous IL-2 was added. In contrast, the proliferative response to a pepsin-extracted type 5 M-protein from Streptococcus pyogenes (pep M5), a recently identified superantigen, required signals provided by phorbol 12-myristate 13-acetate (PMA), IL-1 and IL-6. pep M5 alone did not induce IL-2R expression; however, when combined with PMA, IL-1 and IL-6, IL-2R was expressed. Differences were also observed in the response of the leukemic T-cell line, Jurkat, to PHA and pep M5. Soluble PHA, but not pep M5, induced IL-2 production by these cells in the presence of PMA. Cross-linking by its specific antibody or adsorption of pep M5 to microtiter plates was required to activate Jurkat cells. Both PHA and pep M5 induced Ca2+ mobilization in Jurkat cells; however, only PHA induced a rise in intracellular Ca2+ in purified T-cells, whereas pep M5 was unable to induce this activity unless IL-1, IL-6 and PMA were added. Our data provide biochemical evidence that mitogenic and superantigenic stimulation of T-cells is different. JF - Cellular signalling AU - Majumdar, G AU - Beachey, E H AU - Tomai, M AU - Kotb, M AD - Veterans Administration Medical Center, Research Service, Memphis, TN 38104. Y1 - 1990 PY - 1990 DA - 1990 SP - 521 EP - 530 VL - 2 IS - 6 SN - 0898-6568, 0898-6568 KW - Antigens, Bacterial KW - 0 KW - Bacterial Outer Membrane Proteins KW - Bacterial Proteins KW - Carrier Proteins KW - Cytokines KW - Interleukin-1 KW - Interleukin-2 KW - Interleukin-6 KW - Mitogens KW - Peptide Fragments KW - Phytohemagglutinins KW - Receptors, Interleukin-2 KW - streptococcal M protein KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Receptors, Interleukin-2 -- metabolism KW - Interleukin-1 -- pharmacology KW - Interleukin-2 -- metabolism KW - Tumor Cells, Cultured KW - Antigen-Presenting Cells -- physiology KW - Humans KW - Bacterial Proteins -- immunology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interleukin-6 -- pharmacology KW - Phytohemagglutinins -- pharmacology KW - Peptide Fragments -- immunology KW - Mitogens -- pharmacology KW - Lymphocyte Activation -- immunology KW - Cytokines -- physiology KW - Antigens, Bacterial -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80300297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+signalling&rft.atitle=Differential+signal+requirements+in+T-cell+activation+by+mitogen+and+superantigen.&rft.au=Majumdar%2C+G%3BBeachey%2C+E+H%3BTomai%2C+M%3BKotb%2C+M&rft.aulast=Majumdar&rft.aufirst=G&rft.date=1990-01-01&rft.volume=2&rft.issue=6&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Cellular+signalling&rft.issn=08986568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-06 N1 - Date created - 1991-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of a neonatal murine retrovirus model to evaluate the long-term efficacy and toxicity of antiviral agents. AN - 80286037; 2078021 JF - Annals of the New York Academy of Sciences AU - Bilello, J A AU - MacAuley, C AU - Fredrickson, T N AU - Bell, M M AU - McKissick, C AU - Shapiro, S G AU - Personette, R AU - Eiseman, J L AD - Research Service, Veterans Administration Medical Center, Baltimore, Maryland 21218. Y1 - 1990 PY - 1990 DA - 1990 SP - 238 EP - 251 VL - 616 SN - 0077-8923, 0077-8923 KW - Antiviral Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - AIDS/HIV KW - Mice, Inbred Strains KW - Hematologic Diseases -- chemically induced KW - Animals, Newborn KW - Animals KW - Acquired Immunodeficiency Syndrome -- pathology KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Mice KW - Hematologic Diseases -- pathology KW - Models, Biological KW - Drug Evaluation, Preclinical KW - Female KW - Pregnancy KW - Antiviral Agents -- administration & dosage KW - Zidovudine -- pharmacokinetics KW - Zidovudine -- adverse effects KW - Antiviral Agents -- pharmacology KW - Zidovudine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80286037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Use+of+a+neonatal+murine+retrovirus+model+to+evaluate+the+long-term+efficacy+and+toxicity+of+antiviral+agents.&rft.au=Bilello%2C+J+A%3BMacAuley%2C+C%3BFredrickson%2C+T+N%3BBell%2C+M+M%3BMcKissick%2C+C%3BShapiro%2C+S+G%3BPersonette%2C+R%3BEiseman%2C+J+L&rft.aulast=Bilello&rft.aufirst=J&rft.date=1990-01-01&rft.volume=616&rft.issue=&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-25 N1 - Date created - 1991-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preliminary report on adrenal medullary grafting and cografting with sural nerve in the treatment of hemiparkinson monkeys. AN - 80270356; 2290960 JF - Progress in brain research AU - Watts, R L AU - Bakay, R A AU - Herring, C J AU - Sweeney, K M AU - Colbassani, H J AU - Mandir, A AU - Byrd, L D AU - Iuvone, P M AD - Department of Neurology, Veterans Administration Medical Center, Atlanta, GA. Y1 - 1990 PY - 1990 DA - 1990 SP - 581 EP - 591 VL - 82 SN - 0079-6123, 0079-6123 KW - Levodopa KW - 46627O600J KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Carbidopa KW - MNX7R8C5VO KW - Apomorphine KW - N21FAR7B4S KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Dyskinesia, Drug-Induced -- drug therapy KW - Apomorphine -- pharmacology KW - Disease Models, Animal KW - Dyskinesia, Drug-Induced -- physiopathology KW - Behavior, Animal -- drug effects KW - Behavior, Animal -- physiology KW - Levodopa -- therapeutic use KW - Motor Activity -- drug effects KW - Macaca mulatta KW - Carbidopa -- therapeutic use KW - Dopamine -- cerebrospinal fluid KW - Dyskinesia, Drug-Induced -- surgery KW - Transplantation, Heterotopic -- physiology KW - Transplantation, Heterotopic -- pathology KW - Sural Nerve -- transplantation KW - Caudate Nucleus KW - Adrenal Medulla -- physiology KW - Adrenal Medulla -- transplantation KW - Parkinson Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80270356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+brain+research&rft.atitle=Preliminary+report+on+adrenal+medullary+grafting+and+cografting+with+sural+nerve+in+the+treatment+of+hemiparkinson+monkeys.&rft.au=Watts%2C+R+L%3BBakay%2C+R+A%3BHerring%2C+C+J%3BSweeney%2C+K+M%3BColbassani%2C+H+J%3BMandir%2C+A%3BByrd%2C+L+D%3BIuvone%2C+P+M&rft.aulast=Watts&rft.aufirst=R&rft.date=1990-01-01&rft.volume=82&rft.issue=&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Progress+in+brain+research&rft.issn=00796123&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-04 N1 - Date created - 1991-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reasons for delay of endocrine treatment in cancer of the prostate (until symptomatic metastases occur). AN - 80252311; 2284298 AB - The VACURG studies showed that 1) In early (stage I and II) cancer of the prostate, radical prostatectomy dose not increase survival compared with initial placebo treatment, it is therefore a definite option (and possibly advisable) to initially just observe the patients with early cancer of the prostate (the "watch and see" or "watchful waiting" policy), 2) 1.0 mg as well as 5.0 mg DES daily retards progression from stage III to stage IV but does not improve survival in stage III, 3) 5.0 mg DES daily is associated with increased risk of cardiovascular death, and 4) in stage IV patients, early endocrine treatment (e.g. 1 mg DES) is advisable, especially in younger patients with high-grade tumors. JF - Progress in clinical and biological research AU - Christensen, M M AU - Aagaard, J AU - Madsen, P O AD - Section of Urology, Veterans Administration Hospital, Madison, Wisconsin. Y1 - 1990 PY - 1990 DA - 1990 SP - 7 EP - 14; discussion 15-24 VL - 359 SN - 0361-7742, 0361-7742 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Drug Administration Schedule KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Quality of Life KW - Male KW - Prostatic Neoplasms -- pathology KW - Diethylstilbestrol -- therapeutic use KW - Prostatic Neoplasms -- psychology KW - Neoplasm Metastasis KW - Prostatic Neoplasms -- therapy KW - Orchiectomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80252311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Reasons+for+delay+of+endocrine+treatment+in+cancer+of+the+prostate+%28until+symptomatic+metastases+occur%29.&rft.au=Christensen%2C+M+M%3BAagaard%2C+J%3BMadsen%2C+P+O&rft.aulast=Christensen&rft.aufirst=M&rft.date=1990-01-01&rft.volume=359&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-21 N1 - Date created - 1991-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of the spin trap 5,5 dimethyl-1-pyrroline-N-oxide (DMPO) on human neutrophil function: novel inhibition of neutrophil stimulus-response coupling? AN - 80161181; 2174815 AB - Previously we had utilized the spin trap 5,5 dimethyl-1-pyrroline-N-oxide (DMPO) to detect superoxide (.O2-) formation by human neutrophils stimulated with phorbol myristate acetate (PMA) or opsonized zymosan. When N-formyl-methionyl-leucyl-phenylalanine (FMLP) or concanavalin A were substituted as the neutrophil stimulus spin trap evidence of neutrophil free radical production was not detected. Consequently, the hypothesis that DMPO interfered with neutrophil stimulus response coupling was examined. DMPO exhibited a concentration-related inhibition of neutrophil .O2- secretion (ferricytochrome C reduction) following exposure to six different stimuli. The extent of inhibition was stimulus dependent--large (FMLP, concanavalin A), moderate (PMA, opsonized zymosan, A23187), and mild (arachidonic acid). Inhibition was reversible. Onset was nearly instantaneous and was observed even if DMPO was added after stimulus-induced .O2- formation was ongoing. DMPO had only minimal effect on .O2- production by a cell-free NADPH-oxidase membrane preparation. DMPO also inhibited the neutrophil degranulation response for elastase and lactoferrin but not vitamin B12 binding protein. DMPO-mediated inhibition of neutrophil function was not related to alteration in stimulus binding (FMLP or concanavalin A). DMPO had minimal impact on the stimulus-induced rise in intracellular calcium. However, the presence of DMPO resulted in a concentration-dependent depolarization of the resting neutrophil membrane and blunting of the depolarization response to each stimulus examined. These data are of importance to investigators applying spin-trapping techniques to phagocytic cells and suggest DMPO could be used as a tool for investigating neutrophil stimulus-response mechanisms. JF - Free radical biology & medicine AU - Britigan, B E AU - Hamill, D R AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1990 PY - 1990 DA - 1990 SP - 459 EP - 470 VL - 8 IS - 5 SN - 0891-5849, 0891-5849 KW - Arachidonic Acids KW - 0 KW - Cyclic N-Oxides KW - Cytochrome c Group KW - Opsonin Proteins KW - Spin Labels KW - Concanavalin A KW - 11028-71-0 KW - Superoxides KW - 11062-77-4 KW - Arachidonic Acid KW - 27YG812J1I KW - Calcimycin KW - 37H9VM9WZL KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Zymosan KW - 9010-72-4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Zymosan -- pharmacology KW - Humans KW - Cytoplasmic Granules -- physiology KW - Calcimycin -- pharmacology KW - Cytochrome c Group -- blood KW - Arachidonic Acids -- pharmacology KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Membrane Potentials -- drug effects KW - Cytoplasmic Granules -- drug effects KW - Superoxides -- blood KW - Concanavalin A -- pharmacology KW - Neutrophils -- drug effects KW - Neutrophils -- ultrastructure KW - Cyclic N-Oxides -- pharmacology KW - Neutrophils -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80161181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Effect+of+the+spin+trap+5%2C5+dimethyl-1-pyrroline-N-oxide+%28DMPO%29+on+human+neutrophil+function%3A+novel+inhibition+of+neutrophil+stimulus-response+coupling%3F&rft.au=Britigan%2C+B+E%3BHamill%2C+D+R&rft.aulast=Britigan&rft.aufirst=B&rft.date=1990-01-01&rft.volume=8&rft.issue=5&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-23 N1 - Date created - 1991-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lessons from the genetics of colon cancer. AN - 80107297; 2173130 AB - Remarkable advances in the understanding of specific inherited and acquired genetic events that are important in colonic carcinogenesis have occurred in the last several years. Studies of the population genetics of colon cancer have determined that the gene responsible for familial adenomatous polyposis (FAP), and Gardner's syndrome has been localized on the long arm of chromosome 5 and have more clearly defined the importance of genetic influences in 'sporadic' colon cancer. Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence. Some of these research advances (FAP gene carriage) are already being used clinically to identify individuals at risk for colon cancer, and they offer great promise for the future of both prevention and therapeutic programs. JF - Scandinavian journal of gastroenterology. Supplement AU - Ahnen, D J AD - Gastroenterology Section, Denver Veterans Administration Medical Center, Colorado 80220. Y1 - 1990 PY - 1990 DA - 1990 SP - 166 EP - 176 VL - 175 SN - 0085-5928, 0085-5928 KW - Index Medicus KW - Pedigree KW - Aneuploidy KW - Humans KW - Colonic Neoplasms -- genetics KW - Adenomatous Polyposis Coli -- genetics KW - Oncogenes KW - Genes, Tumor Suppressor KW - Gardner Syndrome -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80107297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+gastroenterology.+Supplement&rft.atitle=Lessons+from+the+genetics+of+colon+cancer.&rft.au=Ahnen%2C+D+J&rft.aulast=Ahnen&rft.aufirst=D&rft.date=1990-01-01&rft.volume=175&rft.issue=&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+gastroenterology.+Supplement&rft.issn=00855928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-05 N1 - Date created - 1990-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of toxicity of radiocontrast agents to renal tubule cells in vitro. AN - 80102469; 2236729 AB - We have previously reported that radiocontrast agents induce direct renal tubule cell toxicity in vitro. The observed toxic effects were markedly potentiated by concomitant hypoxia. In addition, we have reported that the ionic radiocontrast agent diatrizoic acid is more toxic than the nonionic radiocontrast agent iopamidol in this system. Using suspensions enriched in rabbit renal proximal tubule segments, we compared the direct toxicities of the ionic dimeric ioxaglic acid to the nonionic monomeric compound iopamidol. Toxicity was assessed by comparing tubule potassium and calcium content, ATP levels, and respiratory rates after exposure to clinically achievable concentrations of radiocontrast agents. Ioxaglate (25 mM) produced significant declines in tubule cation content and respiratory rate with 30 min of hypoxia followed by 60 min of reoxygenation compared to molar-equivalent concentrations of iopamidol under similar conditions. Meglumine, a cationic compound frequently present in ionic contrast agent solutions, and ioxaglate tubule toxicity was additive. Iopamidol and ioxaglate exhibited similar tubule cell toxicity when comparison was based on iodine content. These experimental results suggest that the intrinsic nephrotoxic potential of ioxaglic acid is greater than that of iopamidol on a molar basis, but that the nephrotoxic potential of the two radiocontrast agents is similar when comparison is based upon iodine content. JF - Renal failure AU - Messana, J M AU - Cieslinski, D A AU - Humes, H D AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1990 PY - 1990 DA - 1990 SP - 75 EP - 82 VL - 12 IS - 2 SN - 0886-022X, 0886-022X KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Iopamidol KW - JR13W81H44 KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Ioxaglic Acid KW - Z40X7EI2AF KW - Index Medicus KW - Osmolar Concentration KW - Calcium -- metabolism KW - Animals KW - Oxygen Consumption -- drug effects KW - In Vitro Techniques KW - Adenosine Triphosphate -- metabolism KW - Rabbits KW - Cell Hypoxia KW - Potassium -- metabolism KW - Ioxaglic Acid -- toxicity KW - Iopamidol -- toxicity KW - Kidney Tubules, Proximal -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80102469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Renal+failure&rft.atitle=Comparison+of+toxicity+of+radiocontrast+agents+to+renal+tubule+cells+in+vitro.&rft.au=Messana%2C+J+M%3BCieslinski%2C+D+A%3BHumes%2C+H+D&rft.aulast=Messana&rft.aufirst=J&rft.date=1990-01-01&rft.volume=12&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Renal+failure&rft.issn=0886022X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-21 N1 - Date created - 1990-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of cytochalasins on lymphocytes: V. Interaction of trifluoperazine and cytochalasin B in inhibition of human lymphocyte proliferation. AN - 80087564; 2229921 AB - Trifluoperazine (TFP), a phenothiazine derivative, is known to inhibit calmodulin-mediated phenomena. We report here that TFP reversibly inhibited lymphocyte proliferative responses to mitogenic lectins. This inhibition was observed only when TFP was added during the early stages of exposure of lymphocytes to the stimulus. Furthermore, at suboptimally inhibitory concentrations of each compound, effects of TFP on lymphocyte proliferation were additive to those of cytochalasin B (CB). Incubation of lymphocytes in TFP (10(-5)-10(-4) M) markedly inhibited cytochalasin B binding to the actin associated, low affinity binding site without affecting its binding to the high affinity site or to the medium affinity site. This effect developed gradually during incubation with TFP, becoming demonstrable after 30 minutes reaching maximum after 30-60 min of incubation at 37 degrees. The findings suggest the occurrence of an interaction of TFP with the lymphocyte cytoskeleton, which may play a role in the impairment in the transmission of the mitogenic signal. JF - Immunopharmacology and immunotoxicology AU - Mookerjee, B K AU - Jung, C Y AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, NY. Y1 - 1990 PY - 1990 DA - 1990 SP - 191 EP - 209 VL - 12 IS - 2 SN - 0892-3973, 0892-3973 KW - Mitogens KW - 0 KW - Trifluoperazine KW - 214IZI85K3 KW - Cytochalasin B KW - 3CHI920QS7 KW - Index Medicus KW - Mitogens -- pharmacology KW - Lymphocytes -- immunology KW - Drug Interactions KW - Kinetics KW - Humans KW - In Vitro Techniques KW - Lymphocytes -- metabolism KW - Lymphocytes -- drug effects KW - Binding Sites KW - Lymphocyte Activation -- drug effects KW - Cytochalasin B -- metabolism KW - Trifluoperazine -- pharmacology KW - Cytochalasin B -- administration & dosage KW - Cytochalasin B -- pharmacology KW - Trifluoperazine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80087564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology+and+immunotoxicology&rft.atitle=The+effects+of+cytochalasins+on+lymphocytes%3A+V.+Interaction+of+trifluoperazine+and+cytochalasin+B+in+inhibition+of+human+lymphocyte+proliferation.&rft.au=Mookerjee%2C+B+K%3BJung%2C+C+Y&rft.aulast=Mookerjee&rft.aufirst=B&rft.date=1990-01-01&rft.volume=12&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology+and+immunotoxicology&rft.issn=08923973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-20 N1 - Date created - 1990-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Venom characteristics as an indicator of hybridization between Crotalus viridis viridis and Crotalus scutulatus scutulatus in New Mexico. AN - 80059736; 2120798 AB - One hundred and thirteen venoms from 46 populations of Crotalus viridis viridis were screened by immunodiffusion for protein toxins antigenically similar to the phospholipase A2 (PLA) toxin 'Mojave toxin', using a polyclonal antibody to it's basic PLA subunit. Venom i.p. LD50 values in mice were recorded from 22 of the 46 populations. The venoms of three of 14 specimens from southwest (S.W.) New Mexico and one specimen from northern Arizona were immunologically positive by the immunodiffusion tests and produced low LD50 values (0.38-0.65 mg/kg) compared to all immunologically negative venoms (0.9-5.5 mg/kg). These four specimens were morphologically typical for C. v. viridis and their venoms were the only samples of 15 southern New Mexico specimens examined by reverse phase HPLC to exhibit peaks corresponding to the acidic and basic subunits of Mojave toxin. Alkaline polyacrylamide gel electrophoresis (PAGE) analysis of the recombined subunit peaks from the C.v. viridis venom from the S.W. New Mexico specimens showed more similarity to Mojave toxin from C.s. scutulatus venom than to similar toxins in C.v. concolor venom. The combined results of the immunodiffusion, lethal toxicity tests, HPLC profiles and PAGE analysis strongly suggest that the venoms of the three New Mexico specimens contain Mojave toxin(s), as a result of some previous hybridization with C.s. scutulatus. The northern Arizona specimen likely contains 'concolor toxin' through integration with C.v. concolor in its' genetic background. JF - Toxicon : official journal of the International Society on Toxinology AU - Glenn, J L AU - Straight, R C AD - Venom Research Laboratory, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1990 PY - 1990 DA - 1990 SP - 857 EP - 862 VL - 28 IS - 7 SN - 0041-0101, 0041-0101 KW - Crotalid Venoms KW - 0 KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Phospholipases A -- analysis KW - Animals KW - Hybridization, Genetic KW - Immunodiffusion KW - Electrophoresis, Polyacrylamide Gel KW - Lethal Dose 50 KW - Mice KW - New Mexico KW - Radioimmunoassay KW - Chromatography, High Pressure Liquid KW - Snakes -- genetics KW - Crotalid Venoms -- toxicity KW - Crotalid Venoms -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80059736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Venom+characteristics+as+an+indicator+of+hybridization+between+Crotalus+viridis+viridis+and+Crotalus+scutulatus+scutulatus+in+New+Mexico.&rft.au=Glenn%2C+J+L%3BStraight%2C+R+C&rft.aulast=Glenn&rft.aufirst=J&rft.date=1990-01-01&rft.volume=28&rft.issue=7&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-05 N1 - Date created - 1990-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of dietary vitamin E on the development of altered hepatic foci and hepatic tumors induced by the peroxisome proliferator ciprofibrate. AN - 79961970; 1975253 AB - The purpose of this study was to determine the effect of the dietary antioxidant vitamin E on hepatocarcinogenesis by peroxisome proliferators which, it is hypothesized, induce tumors by increased production of hydrogen peroxide or other oxygen radicals. Rats were fed diets containing the peroxisome proliferator ciprofibrate and one of three concentrations (10, 50, or 500 ppm) of alpha-tocopheryl acetate for 6 months or 21 months. The incidence of hepatic tumors and the number and volume of gamma-glutamyl-transpeptidase-positive, ATPase-negative, glucose-6-phosphatase-negative, and glucose-6-phosphatase-positive foci were quantified. No tumors or altered hepatic foci were seen at 6 months, but at 21 months the incidence of hepatic tumors and the number and volume of altered hepatic foci were increased in rats fed higher levels of vitamin E. Indices of oxidative damage--concentrations of malonaldehyde, conjugated dienes, and lipid-soluble fluorescence products--were not affected or were lower in rats fed higher amounts of vitamin E; the enhancing effect of vitamin E on the development of altered hepatic foci and hepatic tumors, therefore, was not related to the induction of cellular oxidative damage. Hepatic peroxisomal fatty acid beta-oxidation and vitamin C concentrations were not affected by vitamin E, whereas the glutathione concentration was decreased in rats fed higher amounts of vitamin E. This study shows that increasing the vitamin E content of the diet enhances ciprofibrate-induced hepatocarcinogenesis, but the mechanism of this effect is unclear. JF - Journal of cancer research and clinical oncology AU - Glauert, H P AU - Beaty, M M AU - Clark, T D AU - Greenwell, W S AU - Tatum, V AU - Chen, L C AU - Borges, T AU - Clark, T L AU - Srinivasan, S R AU - Chow, C K AD - Department of Nutrition and Food Science, Veterans Administration Hospital, Lexington, KY. Y1 - 1990 PY - 1990 DA - 1990 SP - 351 EP - 356 VL - 116 IS - 4 SN - 0171-5216, 0171-5216 KW - Fibric Acids KW - 0 KW - Vitamin E KW - 1406-18-4 KW - Clofibric Acid KW - 53PF01Q249 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Glucose-6-Phosphatase KW - EC 3.1.3.9 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - ciprofibrate KW - F8252JGO9S KW - Clofibrate KW - HPN91K7FU3 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Liver -- enzymology KW - gamma-Glutamyltransferase -- analysis KW - Glucose-6-Phosphatase -- analysis KW - Adenosine Triphosphatases -- analysis KW - Drug Synergism KW - Female KW - Clofibric Acid -- toxicity KW - Clofibrate -- analogs & derivatives KW - Liver Neoplasms, Experimental -- enzymology KW - Vitamin E -- pharmacology KW - Liver Neoplasms, Experimental -- chemically induced KW - Vitamin E -- administration & dosage KW - Vitamin E -- blood KW - Liver Neoplasms, Experimental -- blood KW - Clofibric Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79961970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cancer+research+and+clinical+oncology&rft.atitle=Effect+of+dietary+vitamin+E+on+the+development+of+altered+hepatic+foci+and+hepatic+tumors+induced+by+the+peroxisome+proliferator+ciprofibrate.&rft.au=Glauert%2C+H+P%3BBeaty%2C+M+M%3BClark%2C+T+D%3BGreenwell%2C+W+S%3BTatum%2C+V%3BChen%2C+L+C%3BBorges%2C+T%3BClark%2C+T+L%3BSrinivasan%2C+S+R%3BChow%2C+C+K&rft.aulast=Glauert&rft.aufirst=H&rft.date=1990-01-01&rft.volume=116&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+cancer+research+and+clinical+oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-01 N1 - Date created - 1990-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Principal components analysis of the inventory of drinking situations: empirical categories of drinking by alcoholics. AN - 79910310; 2378286 AB - Male alcoholics (n = 336) were given the Inventory of Drinking Situations (IDS), a 100-item questionnaire that asks subjects to rate the frequency with which they drank in various situations during the previous year. A principal components analysis of the responses suggests there are three major categories of situations in which alcoholics are likely to drink: negative affect states, positive affect states combined with social cues to drink, and attempts to test one's ability to control one's drinking. These categories are compared with recent empirical attempts to define categories of alcohol and smoking relapse. JF - Addictive behaviors AU - Cannon, D S AU - Leeka, J K AU - Patterson, E T AU - Baker, T B AD - Psychology Service, Veterans Administration Medical Center, Dallas, TX 75216. Y1 - 1990 PY - 1990 DA - 1990 SP - 265 EP - 269 VL - 15 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Affect KW - Psychometrics KW - Male KW - Veterans -- psychology KW - Alcohol Drinking -- psychology KW - Personality Inventory KW - Alcoholism -- psychology KW - Social Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79910310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Principal+components+analysis+of+the+inventory+of+drinking+situations%3A+empirical+categories+of+drinking+by+alcoholics.&rft.au=Cannon%2C+D+S%3BLeeka%2C+J+K%3BPatterson%2C+E+T%3BBaker%2C+T+B&rft.aulast=Cannon&rft.aufirst=D&rft.date=1990-01-01&rft.volume=15&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-04 N1 - Date created - 1990-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term lipid profiles with isradipine and hydrochlorothiazide treatment in elderly hypertensive patients. AN - 79879595; 1695313 AB - Lipid profiles were determined in 56 elderly patients with benign essential hypertension during an open-label 1-year study of the safety and efficacy of isradipine, a new calcium antagonist, in controlling blood pressure. Patients with diastolic blood pressures between 96 and 115 mm Hg were titrated with isradipine (mean dose of 11 mg/day) to reduce blood pressure to less than 90 mm Hg. Ten of these patients received concomitant hydrochlorothiazide (HCTZ) 50 mg/day for additional control. Sera were analyzed using standard methods at the end of a 2- to 4-week washout period, and at the end of Months 6 and 12, for total cholesterol (CHOL) and HDL- and LDL-cholesterol. Changes in lipid values (mg/dl) from baseline to 12 months with isradipine alone (n = 38) were as follows: CHOL, -7.5; HDL, +3.9 (p less than 0.05); LDL, -6.2; CHOL/HDL, -0.6 (p less than 0.05). For patients receiving concomitant HCTZ (n = 9), the changes were as follows: CHOL, -4.9; HDL, +3.4; LDL, -16.8; CHOL/HDL, -0.4. In conclusion, isradipine alone was associated with significant improvements in HDL cholesterol and total CHOL/HDL ratio. Lipid profiles of patients receiving isradipine and HCTZ were minimally affected. Favorable lipid changes with isradipine suggest that it may have advantages in the treatment of hypertensive patients. JF - Journal of cardiovascular pharmacology AU - Stein, G H AU - Matthews, K AU - Bannatyne, R E AU - Quay, G AU - Lopez, L AU - McCarley, D AD - Ambulatory Care Service, Veterans Administration Medical Center, Gainesville, FL 32602. Y1 - 1990 PY - 1990 DA - 1990 SP - S90 EP - S92 VL - 15 Suppl 1 SN - 0160-2446, 0160-2446 KW - Cholesterol, HDL KW - 0 KW - Cholesterol, LDL KW - Lipids KW - Pyridines KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Cholesterol KW - 97C5T2UQ7J KW - Isradipine KW - YO1UK1S598 KW - Index Medicus KW - Drug Therapy, Combination KW - Cholesterol, LDL -- blood KW - Cholesterol -- blood KW - Prospective Studies KW - Cholesterol, HDL -- blood KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Lipids -- blood KW - Hypertension -- blood KW - Pyridines -- therapeutic use KW - Hydrochlorothiazide -- therapeutic use KW - Pyridines -- adverse effects KW - Hypertension -- drug therapy KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79879595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Long-term+lipid+profiles+with+isradipine+and+hydrochlorothiazide+treatment+in+elderly+hypertensive+patients.&rft.au=Stein%2C+G+H%3BMatthews%2C+K%3BBannatyne%2C+R+E%3BQuay%2C+G%3BLopez%2C+L%3BMcCarley%2C+D&rft.aulast=Stein&rft.aufirst=G&rft.date=1990-01-01&rft.volume=15+Suppl+1&rft.issue=&rft.spage=S90&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-17 N1 - Date created - 1990-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of primary alcoholics, secondary alcoholics, and nonalcoholic psychiatric patients on the MacAndrew Alcoholism Scale. AN - 79804949; 2348352 AB - The MacAndrew Alcoholism (MAC) and Sc scales of the Minnesota Multiphasic Personality Inventory (MMPI) were examined in four groups of 20 male patients. Comparisons were made among primary alcoholics, secondary alcoholics (i.e., alcoholic psychiatric patients), nonalcoholic psychiatric patients (mixed diagnoses), and conservatively defined, nonalcoholic schizophrenics. Primary alcoholics scored higher on the MAC scale than did secondary alcoholics and other groups; schizophrenics scored lower than all other groups. Primary alcoholics were lower on the Sc scale than schizophrenics but did not differ from other groups. The results support MacAndrew's (1981) distinction between primary and secondary alcoholics and suggest that the MAC scale may enhance differentiation among diagnoses other than alcoholism. JF - Journal of personality assessment AU - Ward, L C AU - Jackson, D B AD - Veterans Administration Medical Center, Tuscaloosa, Alabama. Y1 - 1990 PY - 1990 DA - 1990 SP - 729 EP - 735 VL - 54 IS - 3-4 SN - 0022-3891, 0022-3891 KW - Index Medicus KW - Depressive Disorder -- psychology KW - Humans KW - Adult KW - Schizophrenic Psychology KW - Bipolar Disorder -- psychology KW - Middle Aged KW - Personality Disorders -- psychology KW - Psychometrics KW - Male KW - Alcoholism -- diagnosis KW - MMPI KW - Mental Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79804949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+assessment&rft.atitle=A+comparison+of+primary+alcoholics%2C+secondary+alcoholics%2C+and+nonalcoholic+psychiatric+patients+on+the+MacAndrew+Alcoholism+Scale.&rft.au=Ward%2C+L+C%3BJackson%2C+D+B&rft.aulast=Ward&rft.aufirst=L&rft.date=1990-01-01&rft.volume=54&rft.issue=3-4&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-11 N1 - Date created - 1990-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nitrous oxide: a cause of cancer or chemotherapeutic adjuvant? AN - 79799997; 2189194 AB - The administration of nitrous oxide rapidly inactivates the vitamin B12-dependent enzyme methionine synthase. This inactivation disrupts the normal interrelationships between vitamin B12 and folic acid, and results in altered levels of folic acid derivatives and certain amino acids and their metabolites. Attempts have been made to use the antifolate properties of nitrous oxide to treat patients with leukemia. Although transient improvements may be observed in patients with leukemia who are given nitrous oxide, prolonged administration of nitrous oxide is highly toxic and causes marked hematological and neurological abnormalities. Animal and in vitro studies suggest that the action of nitrous oxide may be tumor selective, and that nitrous oxide may interact with and enhance the therapeutic effect of other antitumor agents. However, there is a delicate balance between the possible beneficial and harmful effects of nitrous oxide, and the conditions for which nitrous oxide may prove useful as a chemotherapeutic adjuvant remain to be defined. Concern has also been raised that nitrous oxide may have carcinogenic potential, especially in operating room and dental personnel who are chronically exposed to trace concentrations of this gas. However, there is no convincing evidence to date that nitrous oxide causes cancer in either animals or humans. JF - Seminars in surgical oncology AU - Koblin, D D AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1990 PY - 1990 DA - 1990 SP - 141 EP - 147 VL - 6 IS - 3 SN - 8756-0437, 8756-0437 KW - Antineoplastic Agents KW - 0 KW - Carcinogens KW - Folic Acid KW - 935E97BOY8 KW - Nitrous Oxide KW - K50XQU1029 KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Animals KW - Folic Acid -- metabolism KW - Humans KW - Vitamin B 12 -- metabolism KW - Nitrous Oxide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79799997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+surgical+oncology&rft.atitle=Nitrous+oxide%3A+a+cause+of+cancer+or+chemotherapeutic+adjuvant%3F&rft.au=Koblin%2C+D+D&rft.aulast=Koblin&rft.aufirst=D&rft.date=1990-01-01&rft.volume=6&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Seminars+in+surgical+oncology&rft.issn=87560437&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-29 N1 - Date created - 1990-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reduction of vinblastine neurotoxicity in mice utilizing a collagen matrix carrier. AN - 79785833; 2188316 AB - Vinblastine sulfate (VLB) suspended within a collagen matrix (CM) as a diffusion limiting drug delivery vehicle was examined in vitro, as well as in mouse subcutaneous and brain tumor models. Against RIF-1 and KHT subcutaneous tumors, there was enhancement of antitumor activity with intratumoral (i.t.) delivery of VLB when it was combined with CM and/or epinephrine (epi) provided as a vasoactive agent to limit diffusion of VLB away from the injection site. Furthermore, in pharmacokinetic studies an 3-fold enhancement of tumor exposure to drug (AUC) with the CM-formulation was observed relative to the administration of free VLB i.t. Craniotactic injection of VLB into mouse brain in doses from 0.2 to 2 mg/kg revealed that the CM association markedly reduced the acute toxicity of VLB in normal mouse brain. Furthermore, mice with stereotactically implanted KHT brain tumors treated with 0.2 mg/kg VLB in CM had less tumor present in the brain histologically compared to the free VLB and untreated control groups. JF - Selective cancer therapeutics AU - Sutton, R AU - Yu, N AU - Luck, E AU - Brown, D AU - Conley, F AD - Section of Neurosurgery, Palo Alto Veterans Administration Medical Center, CA. Y1 - 1990 PY - 1990 DA - 1990 SP - 35 EP - 49 VL - 6 IS - 1 SN - 1043-0733, 1043-0733 KW - Drug Carriers KW - 0 KW - Vinblastine KW - 5V9KLZ54CY KW - Collagen KW - 9007-34-5 KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Sarcoma, Experimental -- drug therapy KW - Neoplasm Transplantation KW - Animals KW - Tumor Cells, Cultured -- drug effects KW - Epinephrine -- pharmacology KW - Brain -- pathology KW - Mice, Inbred C3H KW - Sarcoma, Experimental -- pathology KW - Mice KW - Diffusion KW - Injections KW - Male KW - Stereotaxic Techniques KW - Vinblastine -- pharmacokinetics KW - Vinblastine -- administration & dosage KW - Nervous System Diseases -- physiopathology KW - Vinblastine -- toxicity KW - Nervous System Diseases -- chemically induced KW - Nervous System Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79785833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Selective+cancer+therapeutics&rft.atitle=Reduction+of+vinblastine+neurotoxicity+in+mice+utilizing+a+collagen+matrix+carrier.&rft.au=Sutton%2C+R%3BYu%2C+N%3BLuck%2C+E%3BBrown%2C+D%3BConley%2C+F&rft.aulast=Sutton&rft.aufirst=R&rft.date=1990-01-01&rft.volume=6&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Selective+cancer+therapeutics&rft.issn=10430733&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-27 N1 - Date created - 1990-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Assessing depression in substance abusers: Beck Depression Inventory and SCL-90R. AN - 79782927; 2343793 AB - The Beck Depression Inventory (BDI) and two subscales of the Symptom Checklist-90R (SCL-90R) were compared for assessing depression by giving both instruments to 32 inpatient and 22 outpatient substance abusers. For the inpatients (N = 27), 1-month test-retest reliabilities were .82, .87, and .84 for the BDI and the two subscales of the SCL-90R respectively. For both inpatients (two occasions) and outpatients, the BDI correlated highly (.82 to .90) with the two depression subscales of the SCL-90R. Using both the BDI and the SCL-90R in the same study may simply provide redundant information rather than a more comprehensive assessment of depression in substance abusers. JF - Addictive behaviors AU - Moffett, L A AU - Radenhausen, R A AD - Veterans Administration Medical Center, Palo Alto, California. Y1 - 1990 PY - 1990 DA - 1990 SP - 179 EP - 181 VL - 15 IS - 2 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Psychometrics KW - Male KW - Personality Tests KW - Depressive Disorder -- psychology KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology KW - Depressive Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79782927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Assessing+depression+in+substance+abusers%3A+Beck+Depression+Inventory+and+SCL-90R.&rft.au=Moffett%2C+L+A%3BRadenhausen%2C+R+A&rft.aulast=Moffett&rft.aufirst=L&rft.date=1990-01-01&rft.volume=15&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethanol increases PGE and thromboxane production in mouse pregnant uterine tissue. AN - 79781327; 2342401 AB - The teratogenic effect of ethanol in the C57BL/6J mouse can be attenuated by pretreatment with aspirin (ASA). One prominent effect of ASA is to inhibit prostaglandin (PGE) and thromboxane (TXB2) production. We examined the effect of in vivo ethanol exposure on PGE and TXB2 production in a uterine-embryo tissue sample of C57BL/6J mice either before or after in vivo ASA pretreatment on day 10 of gestation. Ethanol increased both PGE and TXB2 production by approximately 20%. ASA caused a marked reduction of PGE and TXB2 in both control and ethanol groups by approximately 80-90%. The mouse strain, gestation time, and study parameters used in this study were the same as in the previously reported ASA attenuation of the teratogenic effect of ethanol. Therefore, the present data add additional support to the hypothesis that prostaglandin and/or thromboxane production may be involved in at least some aspects of fetal alcohol syndrome. JF - Life sciences AU - Anton, R F AU - Becker, H C AU - Randall, C L AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1990 PY - 1990 DA - 1990 SP - 1145 EP - 1153 VL - 46 IS - 16 SN - 0024-3205, 0024-3205 KW - Prostaglandins E KW - 0 KW - Ethanol KW - 3K9958V90M KW - Thromboxane B2 KW - 54397-85-2 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Mice, Inbred C57BL KW - Mice KW - Aspirin -- pharmacology KW - Female KW - Pregnancy KW - Uterus -- metabolism KW - Pregnancy, Animal -- metabolism KW - Ethanol -- pharmacology KW - Prostaglandins E -- biosynthesis KW - Thromboxane B2 -- biosynthesis KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79781327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Ethanol+increases+PGE+and+thromboxane+production+in+mouse+pregnant+uterine+tissue.&rft.au=Anton%2C+R+F%3BBecker%2C+H+C%3BRandall%2C+C+L&rft.aulast=Anton&rft.aufirst=R&rft.date=1990-01-01&rft.volume=46&rft.issue=16&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-28 N1 - Date created - 1990-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans. AN - 79741204; 2184984 AB - The effects of terconazole, a triazole antifungal, on the sterol and carbohydrate composition of Candida albicans was compared with that of three imidazoles: clotrimazole, miconazole, and butoconazole. Exposure of C. albicans to terconazole resulted in a profound depletion of ergosterol with a corresponding increase in lanosterol content versus control cells. Carbohydrate analysis revealed a significant (245%) increase in chitin and a minimal effect on glucan and mannan in terconazole-treated cells. Similar effects on sterol and carbohydrate composition were observed with clotrimazole and miconazole. Butoconazole had a similar effect on sterol composition but had no effect on carbohydrate composition. The decreased ergosterol and increased lanosterol content is consistent with 14 alpha-demethylase inhibition by terconazole and the other azoles. The increase in cell wall chitin is most likely due to deregulation of chitin synthesis secondary to ergosterol depletion in the cell membrane. Because both chitin and ergosterol are critical components of the fungal cell, perturbation of the production and localization of these components by terconazole is likely to contribute to the selective toxicity of this compound for C. albicans and other fungi. JF - Diagnostic microbiology and infectious disease AU - Pfaller, M A AU - Riley, J AU - Koerner, T AD - Veterans Administration Medical Center, Iowa City, Iowa. PY - 1990 SP - 31 EP - 35 VL - 13 IS - 1 SN - 0732-8893, 0732-8893 KW - Antifungal Agents KW - 0 KW - Carbohydrates KW - Glucans KW - Imidazoles KW - Mannans KW - Sterols KW - Triazoles KW - terconazole KW - 0KJ2VE664U KW - butoconazole KW - 0Q771797PH KW - Chitin KW - 1398-61-4 KW - Lanosterol KW - 1J05Z83K3M KW - Miconazole KW - 7NNO0D7S5M KW - Clotrimazole KW - G07GZ97H65 KW - Ergosterol KW - Z30RAY509F KW - Index Medicus KW - Cell Fractionation KW - Mannans -- analysis KW - Cell Wall -- analysis KW - Imidazoles -- pharmacology KW - Clotrimazole -- pharmacology KW - Chitin -- analysis KW - Miconazole -- pharmacology KW - Lanosterol -- analysis KW - Glucans -- analysis KW - Ergosterol -- analysis KW - Antifungal Agents -- pharmacology KW - Sterols -- analysis KW - Triazoles -- pharmacology KW - Candida albicans -- analysis KW - Carbohydrates -- analysis KW - Candida albicans -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79741204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+microbiology+and+infectious+disease&rft.atitle=Effects+of+terconazole+and+other+azole+antifungal+agents+on+the+sterol+and+carbohydrate+composition+of+Candida+albicans.&rft.au=Pfaller%2C+M+A%3BRiley%2C+J%3BKoerner%2C+T&rft.aulast=Pfaller&rft.aufirst=M&rft.date=1990-01-01&rft.volume=13&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-01 N1 - Date created - 1990-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tardive dyskinesia in psychiatric patients with substance use disorders. AN - 79739537; 1970451 AB - The authors report on the incidence of tardive dyskinesia (TD) in a sample of 284 psychiatric patients who chronically abused street drugs; 82.4% had received neuroleptic treatment for the length of their illness (10.5 +/- 5.8 years). The incidence of TD was 15.9%. The incidence of TD was significantly higher in groups of patients in which alcohol alone (25.4%) or in combination with cannabis (26.7%) was the drug of abuse than in those groups in which alcohol was either absent or used in combination with sedatives, opioids, or stimulants. Tardive dyskinesia was absent in patients not treated with neuroleptics and in a control group of drug abusers free of mental disorders. The anatomical distribution was similar to that reported in other psychiatric samples. Mean severity was mild and incapacitation and distress were minimal. Polydrug abuse was dominant in both patients and controls, and alcohol abuse was more frequent among TD patients. It is concluded that chronic use of alcohol by mental patients undergoing pharmacotherapy with neuroleptics enhances the vulnerability of these patients to TD. JF - The American journal of drug and alcohol abuse AU - Olivera, A A AU - Kiefer, M W AU - Manley, N K AD - Veterans Addiction Recovery Center, Cleveland Veterans Administration Medical Center, Brecksville Division, Ohio 44141. Y1 - 1990 PY - 1990 DA - 1990 SP - 57 EP - 66 VL - 16 IS - 1-2 SN - 0095-2990, 0095-2990 KW - Antipsychotic Agents KW - 0 KW - Psychotropic Drugs KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Schizophrenia -- drug therapy KW - Affective Disorders, Psychotic -- drug therapy KW - Male KW - Female KW - Psychotic Disorders -- complications KW - Substance-Related Disorders -- complications KW - Dyskinesia, Drug-Induced -- etiology KW - Psychotropic Drugs -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Alcoholism -- complications KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79739537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Tardive+dyskinesia+in+psychiatric+patients+with+substance+use+disorders.&rft.au=Olivera%2C+A+A%3BKiefer%2C+M+W%3BManley%2C+N+K&rft.aulast=Olivera&rft.aufirst=A&rft.date=1990-01-01&rft.volume=16&rft.issue=1-2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-31 N1 - Date created - 1990-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of in vivo [corrected] biological activity of new agmatine analogs of growth hormone-releasing hormone (GH-RH) AN - 79715923; 2109164 AB - The effects of agmatine analogs of growth hormone releasing hormone (GH-RH) were compared to GH-RH(1-29)-NH2 after intravenous (iv) and subcutaneous (sc) administration to pentobarbital-anesthetized male rats. After the iv injection, the analogs [desNH2-Tyr1,Ala15,Nle27] GH-RH(1-28)Agm (MZ-2-51); [desNH2-Tyr1,D-Lys12,Ala15,Nle27] GH-RH(1-28)Agm (MZ-2-57); [desNH2-Tyr1,Ala15,D-Lys21,Nle27] GH-RH(1-28)Agm (MZ-2-75) and [desNH2-Tyr1, D-Lys12,21, Ala15, Nle27] GH-RH(1-28)Agm (MZ-2-87) showed a potency equivalent to 4.4, 1.9, 1.07 and 1.03 times that of GH-RH (1-29)-NH2, respectively, at 5 min and 5.6, 1.8, 1.9 and 1.8 times higher, respectively, at 15 min. After sc administration, analogs MZ-2-51, MZ-2-57 and MZ-2-75 showed to be 34.3, 14.3 and 10.5 times more potent than the parent hormone at 15 min and 179.1, 88.9 and 45.0 times more active, respectively, at 30 min. In addition, MZ-2-51 had prolonged GH-releasing activity as compared to the standard. We also compared the activity of MZ-2-51 and MZ-2-57 with their homologous L-Arg and D-Arg analogs [desNH2-Tyr1,Ala15,Nle27] GH-RH(1-29)-NH2 (MZ-2-117), [des-NH2Tyr1,D-Lys12, Ala15, Nle27] GH-RH(1-29)NH2 (MZ-2-123) and [desNH2-Tyr1,D-Lys12,Ala15, Nle27,D-Arg29] GH-RH(1-29)NH2 (MZ-2-135) after intramuscular (im) injection. MZ-2-51 induced a somewhat greater GH release than MZ-2-117 at 15 min, both responses being larger than the controls (p less than 0.01) at 15 and 30 min. MZ-2-57, MZ-2-123 and MZ-2-135 given i.m. were able to stimulate GH release only at 15 minutes (p less than 0.05). Animals injected i.m. with MZ-2-51, but not with MZ-2-117, showed GH levels significantly higher than the control group (p less than 0.05) at 60 min. GH-RH(1-29)NH2 had low activity intramuscularly when tested at a dose of 2.5 micrograms. No toxic effects were observed after the iv administration of 1 mg/kg of Agm GH-RH analogs. These results indicate that our Agm analogs are active iv, sc and im and that the substitutions made in these compounds produce increased and prolonged GH releasing activity. These analogs, especially MZ-2-51, should be useful for clinical and veterinary purposes. JF - Life sciences AU - Bokser, L AU - Zarandi, M AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1990 PY - 1990 DA - 1990 SP - 999 EP - 1005 VL - 46 IS - 14 SN - 0024-3205, 0024-3205 KW - Guanidines KW - 0 KW - Agmatine KW - 70J407ZL5Q KW - Growth Hormone KW - 9002-72-6 KW - Growth Hormone-Releasing Hormone KW - 9034-39-3 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Injections, Intravenous KW - Injections, Intramuscular KW - Injections, Subcutaneous KW - Pituitary Gland -- secretion KW - Male KW - Pituitary Gland -- drug effects KW - Growth Hormone-Releasing Hormone -- analogs & derivatives KW - Growth Hormone-Releasing Hormone -- pharmacology KW - Growth Hormone-Releasing Hormone -- administration & dosage KW - Growth Hormone -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79715923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Evaluation+of+in+vivo+%5Bcorrected%5D+biological+activity+of+new+agmatine+analogs+of+growth+hormone-releasing+hormone+%28GH-RH%29&rft.au=Bokser%2C+L%3BZarandi%2C+M%3BSchally%2C+A+V&rft.aulast=Bokser&rft.aufirst=L&rft.date=1990-01-01&rft.volume=46&rft.issue=14&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-24 N1 - Date created - 1990-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Life Sci 1990;47(3):253 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comprehensive system Rorschach data on Vietnam combat veterans. AN - 79676086; 2313538 AB - To better understand and, therefore, treat Vietnam combat veterans with a diagnosis of posttraumatic stress disorder (PTSD), the Rorschach was administered to 50 patients so diagnosed. The most important findings were that, on average: (a) These patients have a low level of stress tolerance and are, therefore, likely to respond impulsively to stressful situations; (b) this low stress tolerance appears to be a long-term adjustment problem; and (c) their perception of reality is unconventional and often distorted. A primary therapeutic indication from these data is that the use of structure would be important for successful therapy. Other findings and therapeutic recommendations are also discussed. JF - Journal of personality assessment AU - Swanson, G S AU - Blount, J AU - Bruno, R AD - Veterans Administration Medical Center, Augusta, GA. Y1 - 1990 PY - 1990 DA - 1990 SP - 160 EP - 169 VL - 54 IS - 1-2 SN - 0022-3891, 0022-3891 KW - Index Medicus KW - Suicide, Attempted -- psychology KW - Combined Modality Therapy KW - Humans KW - Adult KW - Borderline Personality Disorder -- psychology KW - Middle Aged KW - Substance-Related Disorders -- psychology KW - Psychometrics KW - Male KW - Vietnam KW - Combat Disorders -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology KW - Rorschach Test KW - Combat Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79676086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+assessment&rft.atitle=Comprehensive+system+Rorschach+data+on+Vietnam+combat+veterans.&rft.au=Swanson%2C+G+S%3BBlount%2C+J%3BBruno%2C+R&rft.aulast=Swanson&rft.aufirst=G&rft.date=1990-01-01&rft.volume=54&rft.issue=1-2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Pers Assess 1990 Fall;55(1-2):391 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The SHARP carwash: a community-oriented work program for substance abuse patients. AN - 79676004; 2315766 JF - Social work AU - Stead, P AU - Rozynko, V AU - Berman, S AD - Veterans Administration Medical Center, Menlo Park, CA 94025. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 79 EP - 80 VL - 35 IS - 1 SN - 0037-8046, 0037-8046 KW - Index Medicus KW - California KW - Humans KW - Male KW - Hospitals, Veterans KW - Rehabilitation, Vocational KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79676004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+work&rft.atitle=The+SHARP+carwash%3A+a+community-oriented+work+program+for+substance+abuse+patients.&rft.au=Stead%2C+P%3BRozynko%2C+V%3BBerman%2C+S&rft.aulast=Stead&rft.aufirst=P&rft.date=1990-01-01&rft.volume=35&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Social+work&rft.issn=00378046&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detoxification with phenobarbital of alprazolam-dependent polysubstance abusers. AN - 79668386; 2313770 AB - Alprazolam appears to have an abuse liability among opiate addicts, and detoxification can be prolonged. The authors describe experience with five methadone maintenance patients who were polysubstance abusers and were admitted specifically for detoxification from alprazolam dependence. Phenobarbital in tapering doses adequately suppressed withdrawal symptoms and shortened hospitalization. JF - Journal of substance abuse treatment AU - Ravi, N V AU - Maany, I AU - Burke, W M AU - Dhopesh, V AU - Woody, G E AD - Center for Research and Treatment of Substance Abuse, Philadelphia Veterans Administration Medical Center, University of Pennsylvania. Y1 - 1990 PY - 1990 DA - 1990 SP - 55 EP - 58 VL - 7 IS - 1 SN - 0740-5472, 0740-5472 KW - Street Drugs KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Phenobarbital KW - YQE403BP4D KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Phenobarbital -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79668386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Detoxification+with+phenobarbital+of+alprazolam-dependent+polysubstance+abusers.&rft.au=Ravi%2C+N+V%3BMaany%2C+I%3BBurke%2C+W+M%3BDhopesh%2C+V%3BWoody%2C+G+E&rft.aulast=Ravi&rft.aufirst=N&rft.date=1990-01-01&rft.volume=7&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combinations of 4-hydroperoxycyclophosphamide (4-HC) and cisplatin for bone marrow purging in autologous marrow transplantation: an update. AN - 79657216; 2309001 AB - We are studying the usefulness of combinations of 4-HC and cisplatin as a potential purging regimen for autologous bone marrow transplantation. In all of our studies, in vitro cytotoxicity was determined by clonogenic assay, and drug interaction was quantitated using the multiple drug-effect analysis method. The cells were incubated for one hour (4-HC) and/or 4 hours (cisplatin). We found that the drugs in combination had cytotoxic synergism against human leukemia cell lines (K-562 and Raji). The synergism was sequence-dependent (cells must be exposed to 4-HC first), was present at various molar ratios of the drugs, and most pronounced at high levels of cell kill. We also found that the drugs had cytotoxic synergism against normal human marrow progenitors (CFU-GM). However, the leukemic cells were approximately 55 times more sensitive to the combination than CFU-GM. In a murine system, the drugs were synergistic against L1210 leukemia cells and normal murine CFU-GM, but L1210 cells were at least 130 times more sensitive to the combination than CFU-GM. To determine the ability of L1210 cells to grow in vivo after exposure to the drugs, BDF1 mice were injected with 2 x 10(4) cells which had been incubated with 4-HC and/or cisplatin. The survival time of untreated controls was 13 +/- 2.8 days. For treated groups, the cure rates after 50 days of observation were 33% (4-HC, 40 uM), 0% (cisplatin, 8 uM), and 100% (4-HC + cisplatin). Finally, at concentrations resulting in equivalent toxicity to marrow CFU-GM, cisplatin seemed to be more toxic to murine spleen blast colony forming cells (CFC-BC) than 4-HC. The drugs in combination appeared to have at least additive toxicities against CFC-BC. JF - Progress in clinical and biological research AU - Peters, R H AU - Brandon, C S AU - Avila, L A AU - Gale, G R AU - Stuart, R K AD - Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Veterans Administration Hospital, Charleston, South Carolina 29425. Y1 - 1990 PY - 1990 DA - 1990 SP - 57 EP - 68 VL - 333 SN - 0361-7742, 0361-7742 KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - perfosfamide KW - U880A4FUDA KW - Index Medicus KW - Stem Cells -- drug effects KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Spleen -- cytology KW - Humans KW - Leukemia L1210 -- therapy KW - Mice KW - Transplantation, Autologous KW - Cisplatin -- administration & dosage KW - Bone Marrow Cells KW - Lymphocyte Activation -- drug effects KW - Cyclophosphamide -- analogs & derivatives KW - Tumor Cells, Cultured KW - Spleen -- drug effects KW - Drug Synergism KW - Male KW - Bone Marrow Transplantation -- methods KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79657216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Combinations+of+4-hydroperoxycyclophosphamide+%284-HC%29+and+cisplatin+for+bone+marrow+purging+in+autologous+marrow+transplantation%3A+an+update.&rft.au=Peters%2C+R+H%3BBrandon%2C+C+S%3BAvila%2C+L+A%3BGale%2C+G+R%3BStuart%2C+R+K&rft.aulast=Peters&rft.aufirst=R&rft.date=1990-01-01&rft.volume=333&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-09 N1 - Date created - 1990-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bioavailability of clindamycin during peritoneal dialysis. AN - 79656603; 2155762 AB - Clindamycin phosphate becomes biologically active only with cleavage of the phosphate ester bond. A rat model was used to examine the amount of biologically active clindamycin attainable in the dialysate and in the blood during peritoneal dialysis. Intravenous administration of 10 mg/kg clindamycin phosphate alone without peritoneal dialysis produced peak blood levels of 15-20 micrograms/ml. With peritoneal dialysis, blood levels of less than 5 micrograms/ml were achieved. When clindamycin phosphate was added to the dialysis fluid at an initial concentration of 10 mg/ml, less than 5 micrograms/ml of the active antibiotic can be detected in the dialysis return fluids. Even in rats with induced peritonitis, less than 15 micrograms/ml could be found in the dialysis returns. With or without peritonitis, less than 5 micrograms/ml of active clindamycin was attained in blood from peritoneal installation alone. The conversion of the ester to the active compound appears to be the major problem. It is recommended that in those clinical situations in which the patient requires peritoneal dialysis, an alternate antimicrobial agent be used in place of clindamycin to avoid infections in the abdominal cavity or the blood while under therapy. JF - Chemotherapy AU - Eng, R H AU - Smith, S M AU - Buccini, F AU - Naumoff, M AU - Sastrasinh, S AD - Medical Service, Veterans Administration Medical Center, East Orange, N.J. Y1 - 1990 PY - 1990 DA - 1990 SP - 85 EP - 90 VL - 36 IS - 2 SN - 0009-3157, 0009-3157 KW - Clindamycin KW - 3U02EL437C KW - Silica Gel KW - 60650-90-0 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Injections, Intravenous KW - Peritonitis -- chemically induced KW - Peritonitis -- metabolism KW - Biological Availability KW - Clindamycin -- blood KW - Peritoneal Dialysis KW - Clindamycin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79656603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Bioavailability+of+clindamycin+during+peritoneal+dialysis.&rft.au=Eng%2C+R+H%3BSmith%2C+S+M%3BBuccini%2C+F%3BNaumoff%2C+M%3BSastrasinh%2C+S&rft.aulast=Eng&rft.aufirst=R&rft.date=1990-01-01&rft.volume=36&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Chemotherapy&rft.issn=00093157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary bombesin and calcitonin in hamsters during exposure to hyperoxia and diethylnitrosamine. AN - 79637013; 2306367 AB - Combined exposure of hamsters to 60% hyperoxia and the carcinogen diethylnitrosamine for 6 wk resulted in the development of lung tumors. This was associated with progressive loss of body weight as well as increases in the pulmonary-associated peptides, mammalian bombesin (MB) and immunoreactive calcitonin (iCT). After 3 wk of exposure, multiple bronchial epithelial hyperplastic foci were noted, along with increased lung levels of MB and iCT as well as increased serum levels of MB. At this time, immunocytochemistry revealed the presence of MB and iCT within hyperplastic pulmonary neuroendocrine (PNE) cells. In addition, the localization of MB to alveolar type II cells was noted, along with the presence of lamellar bodies and secretion granules in these cells on electron microscopy. After 6 wk of exposure, distinctive microscopic pulmonary tumorlets were seen. These tumorlets were associated with a marked increase in lung and serum MB, and to a lesser extent lung and serum iCT. At this time, MB and iCT were localized exclusively to these abnormal PNE cell sites. These results, which may have relevance in humans, suggest that endogenous peptides may be important components in the process of development of neuroendocrine cancer. JF - American journal of respiratory cell and molecular biology AU - Nylen, E S AU - Becker, K L AU - Joshi, P A AU - Snider, R H AU - Schuller, H M AD - Section of Endrocrinology, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 25 EP - 31 VL - 2 IS - 1 SN - 1044-1549, 1044-1549 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Calcitonin KW - 9007-12-9 KW - Bombesin KW - PX9AZU7QPK KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Body Weight KW - Cytoplasmic Granules -- ultrastructure KW - Animals KW - Oxygen -- pharmacology KW - Pulmonary Alveoli -- ultrastructure KW - Mesocricetus KW - Pulmonary Alveoli -- analysis KW - Diethylnitrosamine -- pharmacology KW - Immunohistochemistry KW - Male KW - Chromatography, High Pressure Liquid KW - Cricetinae KW - Neurosecretory Systems -- analysis KW - Bombesin -- analysis KW - Lung Neoplasms -- ultrastructure KW - Lung -- analysis KW - Lung Neoplasms -- analysis KW - Calcitonin -- analysis KW - Bombesin -- blood KW - Lung -- ultrastructure KW - Neurosecretory Systems -- ultrastructure KW - Calcitonin -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79637013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Pulmonary+bombesin+and+calcitonin+in+hamsters+during+exposure+to+hyperoxia+and+diethylnitrosamine.&rft.au=Nylen%2C+E+S%3BBecker%2C+K+L%3BJoshi%2C+P+A%3BSnider%2C+R+H%3BSchuller%2C+H+M&rft.aulast=Nylen&rft.aufirst=E&rft.date=1990-01-01&rft.volume=2&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-03 N1 - Date created - 1990-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sepsis of vascular catheters. II: In vitro disinfection of colonized tubing. AN - 79614373; 2406273 AB - Preparatory to development of in situ disinfection of implanted catheters, silicone rubber tubing colonized by incubation with Staphylococcus aureus, Staphylococcus epidermidis, or Klebsiella pneumoniae was used to test the efficacy of various chemicals in vitro. Protocols sterilizing all segments colonized for 24 h (n = 30) were immersion into 50% povidone iodine for 5 and 60 min, 100% povidone iodine for 5, 15, and 60 min, 1.2 x 10(3) ppm chlorine dioxide for 15 and 60 min, and 1.2 x 10(3) ppm chlorine dioxide buffered to pH 5.1 for 60 min. Immersion in up to 2% chlorhexidine, 7.4% formaldehyde, or 6% sodium hypochlorite for up to 60 min failed to sterilize all segments. None of 117 control segments were sterilized. Segments colonized for seven days were sterilized by immersion into 100% povidone iodine for 15 or 60 min. Use of 1.2 x 10(3) ppm chlorine dioxide for 60 min sterilized 97% of segments tested. Lower concentrations and shorter exposure times failed to sterilize all segments. Eighteen silicone rubber catheters, colonized on the outer surface, were all sterilized within 24 h by a chlorine dioxide solution placed in the lumen and diffusing through the wall to kill the bacteria. JF - Journal of biomedical materials research AU - Dennis, M B AU - Jones, D R AU - Tenover, F C AD - Seattle Veterans Administration Medical Center, Washington 98108. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 95 EP - 105 VL - 24 IS - 1 SN - 0021-9304, 0021-9304 KW - Chlorine Compounds KW - 0 KW - Disinfectants KW - Oxides KW - Solutions KW - Povidone-Iodine KW - 25655-41-8 KW - Chlorine KW - 4R7X1O2820 KW - chlorine dioxide KW - 8061YMS4RM KW - Index Medicus KW - Humans KW - Staphylococcus aureus KW - Staphylococcus epidermidis KW - Microscopy, Electron, Scanning KW - Klebsiella pneumoniae KW - Disinfection -- methods KW - Catheterization -- instrumentation KW - Sterilization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79614373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomedical+materials+research&rft.atitle=Sepsis+of+vascular+catheters.+II%3A+In+vitro+disinfection+of+colonized+tubing.&rft.au=Dennis%2C+M+B%3BJones%2C+D+R%3BTenover%2C+F+C&rft.aulast=Dennis&rft.aufirst=M&rft.date=1990-01-01&rft.volume=24&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomedical+materials+research&rft.issn=00219304&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-23 N1 - Date created - 1990-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction. AN - 79613605; 2137299 AB - This study was designed to determine the changes in the heart that result from inhibition of long-chain fatty acid oxidation with 2-tetradecylglycidic acid (TDGA). Male Sprague-Dawley rats (n = 64) were treated with TDGA (20 mg.kg-1.day-1) or a comparable volume of vehicle by gavage feeding for 7 or 21 days. In conscious rats TDGA produced no changes in heart rate, left ventricular systolic or end-diastolic pressures, left ventricular pressure development (dP/dt), or the time constant of left ventricular relaxation. Left ventricular developed pressure was not changed at 21 days. TDGA increased left ventricular weight, left ventricular weight-to-body weight ratio, and total heart weight-to-body weight ratio. Left ventricular endocardial and epicardial myocyte volumes were increased by 53 and 65%, respectively. Myocardial triglyceride content was increased threefold. Left ventricular chamber stiffness constants between end-diastolic pressures of 0 and 30 mmHg were increased, and left ventricular end-diastolic volumes at operating end-diastolic pressures were decreased at both 7 and 21 days. The myocardial stiffness constant was also increased at 7 and 21 days. Thus inhibition of long-chain fatty acid oxidation with TDGA increased left ventricular mass and altered left ventricular chamber and muscle stiffness without changing left ventricular relaxation or systolic function. We conclude that inhibition of long-chain fatty acid oxidation produced an unusual model of left ventricular hypertrophy and diastolic dysfunction characterized by abnormalities of passive-elastic properties but preserved relaxation. JF - The American journal of physiology AU - Litwin, S E AU - Raya, T E AU - Gay, R G AU - Bedotto, J B AU - Bahl, J J AU - Anderson, P G AU - Goldman, S AU - Bressler, R AD - Department of Internal Medicine, Veterans Administration Medical Center, Tucson 85723. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - H51 EP - H56 VL - 258 IS - 1 Pt 2 SN - 0002-9513, 0002-9513 KW - Epoxy Compounds KW - 0 KW - Fatty Acids KW - 2-tetradecylglycidic acid KW - R326X4TRBY KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Myocardium -- pathology KW - Epoxy Compounds -- pharmacology KW - Cardiomegaly -- chemically induced KW - Hemodynamics KW - Microscopy, Electron KW - Cardiomegaly -- pathology KW - Time Factors KW - Male KW - Cardiomegaly -- metabolism KW - Models, Cardiovascular KW - Fatty Acids -- antagonists & inhibitors KW - Fatty Acids -- pharmacology KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79613605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Chronic+inhibition+of+fatty+acid+oxidation%3A+new+model+of+diastolic+dysfunction.&rft.au=Litwin%2C+S+E%3BRaya%2C+T+E%3BGay%2C+R+G%3BBedotto%2C+J+B%3BBahl%2C+J+J%3BAnderson%2C+P+G%3BGoldman%2C+S%3BBressler%2C+R&rft.aulast=Litwin&rft.aufirst=S&rft.date=1990-01-01&rft.volume=258&rft.issue=1+Pt+2&rft.spage=H51&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human immunodeficiency virus and hepatitis B virus infections in alcoholics. AN - 79612457; 2405411 JF - Progress in clinical and biological research AU - Jacobson, J M AU - Worner, T M AU - Sacks, H S AU - Lieber, C S AD - Infectious Diseases Section, Bronx Veterans Administration Medical Center, New York. Y1 - 1990 PY - 1990 DA - 1990 SP - 67 EP - 73 VL - 325 SN - 0361-7742, 0361-7742 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Epidemiologic Factors KW - Acquired Immunodeficiency Syndrome -- complications KW - Hepatitis B -- complications KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Alcoholism -- epidemiology KW - Alcoholism -- complications KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79612457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Human+immunodeficiency+virus+and+hepatitis+B+virus+infections+in+alcoholics.&rft.au=Jacobson%2C+J+M%3BWorner%2C+T+M%3BSacks%2C+H+S%3BLieber%2C+C+S&rft.aulast=Jacobson&rft.aufirst=J&rft.date=1990-01-01&rft.volume=325&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-15 N1 - Date created - 1990-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of pulmonary edema induced by a diacylglycerol second messenger. AN - 79611085; 2154134 AB - We investigated the effect of dioctanoylglycerol (DOG), a second messenger of protein kinase C (PKC) activation, in the absence and presence of neutrophils in isolated perfused guinea pig lung. DOG was given after a base-line isogravimetric steady-state period. Pulmonary capillary pressure (Ppc) and change in lung weight (delta W) were monitored at 15, 30, and 60 min. Capillary filtration coefficient (Kf,c, an index of vascular permeability) was measured during base-line period and at 30 min. DOG increased the Ppc and delta W at 30 and 60 min, and the Kfc at 30 min. Monooctanoylglycerol, a monoacylglycerol that does not activate PKC, had no effect on Ppc, Kf,c, and delta W. Pretreatment with two different PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methyl piperazine or staurosporin, prevented the pulmonary response to DOG. With neutrophils present, DOG caused greater increases in delta W and the (wet-dry)-to-dry wt ratio compared with DOG group. Response to DOG+ neutrophils was due to oxygen radical production because it was prevented by pretreatment with catalase and because DOG increased superoxide release from neutrophils. PKC activation using DOG in the isolated lung results in pulmonary edema mediated by increases in capillary pressure and vascular permeability. Lung weight-gain response to DOG is greater in the presence of neutrophils. Response to DOG+ neutrophils is mediated by oxygen radicals. JF - The American journal of physiology AU - Johnson, A AU - Hocking, D C AU - Ferro, T J AD - Research Service, Veterans Administration Medical Center, Albany, New York. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - H85 EP - H91 VL - 258 IS - 1 Pt 2 SN - 0002-9513, 0002-9513 KW - Anions KW - 0 KW - Diglycerides KW - Glycerides KW - Superoxides KW - 11062-77-4 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Guinea Pigs KW - Anions -- metabolism KW - Capillary Permeability -- drug effects KW - Neutrophils -- metabolism KW - Superoxides -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Lung -- anatomy & histology KW - Biomechanical Phenomena KW - In Vitro Techniques KW - Pulmonary Circulation -- drug effects KW - Lung -- drug effects KW - Neutrophils -- physiology KW - Female KW - Male KW - Organ Size -- drug effects KW - Second Messenger Systems KW - Diglycerides -- pharmacology KW - Pulmonary Edema -- chemically induced KW - Diglycerides -- physiology KW - Glycerides -- physiology KW - Glycerides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79611085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Mechanisms+of+pulmonary+edema+induced+by+a+diacylglycerol+second+messenger.&rft.au=Johnson%2C+A%3BHocking%2C+D+C%3BFerro%2C+T+J&rft.aulast=Johnson&rft.aufirst=A&rft.date=1990-01-01&rft.volume=258&rft.issue=1+Pt+2&rft.spage=H85&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness. AN - 79608268; 2405468 AB - Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a 23-kDa glycoprotein with remarkably diverse effects on immune and nonimmune cells. GM-CSF induces differentiation of granulocyte, macrophage, and eosinophil precursor cells. Proliferation of monocyte-macrophages, T lymphocytes, keratinocytes, and endothelial cells is also stimulated by GM-CSF. In addition, GM-CSF alters the functional properties of mature granulocytes, macrophages, eosinophils, and basophils. GM-CSF is produced by T lymphocytes, macrophages, and several cell types in extramedullary sites, where it may act in a paracrine manner to regulate the local response to antigenic challenge. Clinical trials of GM-CSF have been conducted in patients with AIDS, aplastic anemia, myelodysplastic syndromes, and sarcoma and following bone marrow transplantation and accidental radiation exposure. GM-CSF significantly increased circulating numbers of several myeloid cells and produced dose-dependent toxicity consisting primarily of myalgias, fever, fluid retention, and serosal effusions. Additional studies are needed to define the role of GM-CSF in treatment of patients with qualitative and quantitative dysfunction of immune cells. JF - Reviews of infectious diseases AU - Ruef, C AU - Coleman, D L AD - Department of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516. PY - 1990 SP - 41 EP - 62 VL - 12 IS - 1 SN - 0162-0886, 0162-0886 KW - Colony-Stimulating Factors KW - 0 KW - Growth Substances KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Index Medicus KW - Animals KW - Humans KW - Cell Division -- drug effects KW - Growth Substances -- genetics KW - Colony-Stimulating Factors -- therapeutic use KW - Growth Substances -- therapeutic use KW - Growth Substances -- pharmacology KW - Growth Substances -- biosynthesis KW - Granulocytes -- drug effects KW - Colony-Stimulating Factors -- biosynthesis KW - Macrophages -- drug effects KW - Colony-Stimulating Factors -- genetics KW - Colony-Stimulating Factors -- pharmacology KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79608268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Granulocyte-macrophage+colony-stimulating+factor%3A+pleiotropic+cytokine+with+potential+clinical+usefulness.&rft.au=Ruef%2C+C%3BColeman%2C+D+L&rft.aulast=Ruef&rft.aufirst=C&rft.date=1990-01-01&rft.volume=12&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-15 N1 - Date created - 1990-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Possible interaction between ciprofloxacin and warfarin. AN - 79606716; 2301186 AB - A 72-year-old man had been taking warfarin for a pulmonary embolus and recurrent deep-vein thromboses. His prothrombin times (PTs) were maintained between 15 and 18 sec (PT ratio 1.25-1.5 x control) for several months on a dose of warfarin 2.5 mg/d. Six weeks prior to starting ciprofloxacin 500 mg bid, the patient's PT was 15.5 sec (Pt ratio 1.29 x control). After one week of ciprofloxacin, his PT had increased to 22 sec (PT ratio 1.83 x control). No other causes for the increase were apparent. It is recommended that patients receiving both medications have their prothrombin times carefully monitored and warfarin doses adjusted only as necessary. JF - DICP : the annals of pharmacotherapy AU - Kamada, A K AD - Pharmacy Service, Veterans Administration Medical Center, Denver, CO. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 27 EP - 28 VL - 24 IS - 1 SN - 1042-9611, 1042-9611 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - Drug Interactions KW - Humans KW - Pulmonary Embolism -- drug therapy KW - Aged KW - Thrombophlebitis -- drug therapy KW - Prothrombin Time KW - Male KW - Warfarin -- adverse effects KW - Ciprofloxacin -- therapeutic use KW - Ciprofloxacin -- adverse effects KW - Warfarin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79606716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DICP+%3A+the+annals+of+pharmacotherapy&rft.atitle=Possible+interaction+between+ciprofloxacin+and+warfarin.&rft.au=Kamada%2C+A+K&rft.aulast=Kamada&rft.aufirst=A&rft.date=1990-01-01&rft.volume=24&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=DICP+%3A+the+annals+of+pharmacotherapy&rft.issn=10429611&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-13 N1 - Date created - 1990-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of chronic ivermectin treatment on GABA receptor function in ethanol withdrawal-seizure prone and resistant mice. AN - 79605642; 2153865 AB - Ivermectin, a potent, effective anthelmintic, is easy to administer, has a broad spectrum of action and a wide safety margin. However, no testing has been done in hosts genetically selected for seizure susceptibility which may be more sensitive to the effects of ivermectin than other animals. This was done in the present experiments with seizure prone and seizure resistant mice infested with Syphacia obvelata (pinworm). These subjects were treated daily with oral ivermectin in their drinking water every other week for six weeks, for a total of 21 days. The treatment cleared the mice of the pinworm infestation, but did not alter the seizure susceptibility or binding parameters of [3H]flunitrazepam in either of the selected lines. JF - Laboratory animal science AU - Diggs, H E AU - Feller, D J AU - Crabbe, J C AU - Merrill, C AU - Farrell, E AD - Veterans Administration Medical Center, Animal Research Service, Portland, OR 97207. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 68 EP - 71 VL - 40 IS - 1 SN - 0023-6764, 0023-6764 KW - Receptors, GABA-A KW - 0 KW - Ethanol KW - 3K9958V90M KW - Flunitrazepam KW - 620X0222FQ KW - Ivermectin KW - 70288-86-7 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Animals KW - Oxyuroidea KW - Brain Chemistry KW - Mice KW - Flunitrazepam -- metabolism KW - Ovum KW - Seizures -- chemically induced KW - Bicuculline -- pharmacology KW - Receptors, GABA-A -- physiology KW - Ivermectin -- pharmacology KW - Bicuculline -- administration & dosage KW - Receptors, GABA-A -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79605642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+animal+science&rft.atitle=Effect+of+chronic+ivermectin+treatment+on+GABA+receptor+function+in+ethanol+withdrawal-seizure+prone+and+resistant+mice.&rft.au=Diggs%2C+H+E%3BFeller%2C+D+J%3BCrabbe%2C+J+C%3BMerrill%2C+C%3BFarrell%2C+E&rft.aulast=Diggs&rft.aufirst=H&rft.date=1990-01-01&rft.volume=40&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Laboratory+animal+science&rft.issn=00236764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-15 N1 - Date created - 1990-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The history of anxiety symptoms among 171 primary alcoholics. AN - 79602233; 2299847 AB - This study used patient and resource person face-to-face interviews to explore the history of anxiety symptoms and syndromes in 171 primary alcoholic male veterans on an alcohol treatment program. Almost all men (98%) reported at least one symptom of anxiety during drinking or withdrawal, including 80% who related problems with palpitations and/or shortness of breath. In addition, seven men (4%) described at least one episode of panic lasting from 1 to 4 or more hours, although only two of these individuals experienced three or more panic attacks in a 3-week period in the context of heavy drinking or withdrawal. No men evidenced repetitive panic attacks either before the onset of heavy drinking or in the context of a protracted period of abstinence. Seven individuals (4%) fulfilled criteria for generalized anxiety symptoms when dry for 3 or more months. The histories of treatment by mental health workers or in psychiatric facilities taken together with the symptom picture generated from patient and resource person interviews do not indicate an elevated incidence of either panic disorder or generalized anxiety that is independent of heavy drinking. JF - Journal of studies on alcohol AU - Schuckit, M A AU - Irwin, M AU - Brown, S A AD - Alcohol Research Center, San Diego Veterans Administration Medical Center, California 92161. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 34 EP - 41 VL - 51 IS - 1 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Personality Tests KW - Arousal -- drug effects KW - Anxiety Disorders -- psychology KW - Risk Factors KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Adaptation, Psychological -- drug effects KW - Male KW - Alcoholism -- rehabilitation KW - Anxiety -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79602233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=The+history+of+anxiety+symptoms+among+171+primary+alcoholics.&rft.au=Schuckit%2C+M+A%3BIrwin%2C+M%3BBrown%2C+S+A&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1990-01-01&rft.volume=51&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-08 N1 - Date created - 1990-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Remoxipride, a new selective D2 antagonist, and haloperidol in cebus monkeys. AN - 79601689; 1967845 AB - 1. Nine Cebus monkeys, 6 with mild spontaneous oral dyskinesia (tongue protrusions), were tested with two dopamine D2 antagonists, remoxipride (a new substituted benzamide) and haloperidol, and with two dopamine agonists, methylphenidate and apomorphine. 2. Remoxipride 4 and 8 mg/kg and haloperidol 0.01 and 0.02 mg/kg given alone induced identical dystonic-dyskinetic syndromes. 3. Methylphenidate 0.5 mg/kg caused increased arousal, but reduced oral dyskinesia, while apomorphine 0.25 mg/kg slightly increased arousal and induced/aggravated oral dyskinesia. 4. Remoxipride 2 and 4 mg/kg and haloperidol 0.005 and 0.01 mg/kg equally antagonized the methylphenidate- and apomorphine-induced arousal, but not oral dyskinesia. 5. Marked sedation was seen when apomorphine was given together with either D2 receptor antagonists. 6. It is concluded that remoxipride and haloperidol have a similar qualitative effect in motor behavior in Cebus monkeys, but the quantitative difference between the dystonia-inducing dose levels of the two drugs compared with the antipsychotic dose levels (estimated from clinical studies) suggests that remoxipride may cause relatively few extrapyramidal side-effects in human. JF - Progress in neuro-psychopharmacology & biological psychiatry AU - Gerlach, J AU - Casey, D E AD - Dept. of Psychiatry, Veterans Administration Medical Center, Portland, Oregon. Y1 - 1990 PY - 1990 DA - 1990 SP - 103 EP - 112 VL - 14 IS - 1 SN - 0278-5846, 0278-5846 KW - Antipsychotic Agents KW - 0 KW - Benzamides KW - Receptors, Dopamine KW - Receptors, Dopamine D2 KW - Remoxipride KW - 0223RD59PE KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Parkinson Disease, Secondary -- physiopathology KW - Animals KW - Arousal KW - Disease Models, Animal KW - Motor Activity -- drug effects KW - Cebus KW - Parkinson Disease -- physiopathology KW - Dyskinesia, Drug-Induced -- physiopathology KW - Male KW - Female KW - Receptors, Dopamine -- drug effects KW - Receptors, Dopamine -- physiology KW - Benzamides -- pharmacology KW - Antipsychotic Agents -- pharmacology KW - Haloperidol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79601689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.atitle=Remoxipride%2C+a+new+selective+D2+antagonist%2C+and+haloperidol+in+cebus+monkeys.&rft.au=Gerlach%2C+J%3BCasey%2C+D+E&rft.aulast=Gerlach&rft.aufirst=J&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.issn=02785846&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Additional psychiatric illness by Diagnostic Interview Schedule in male alcoholics. AN - 79597169; 2297986 AB - Seventy-four male veterans entering an alcohol abuse treatment program were screened for additional psychiatric diagnoses using the Diagnostic Interview Schedule (DIS). Fifty-four of these also completed a questionnaire on personal and family drinking history. Over half (54.1%) had another diagnosis. The most common syndromes other than substance abuse were antisocial personality disorder, phobic disorder, and depression. In each of these cases, the presence of the additional disorder accelerated the course of the alcohol problem significantly. The difference in course between syndromes was dwarfed by the time of presentation by the difference between "pure" alcoholism and alcoholism with another diagnosis. The primary versus secondary distinction appeared to account for only a part of this effect. JF - Comprehensive psychiatry AU - Herz, L R AU - Volicer, L AU - D'Angelo, N AU - Gadish, D AD - Psychiatry Service, Edith Nourse Rogers Memorial Veterans Administration Hospital, Bedford, MA 01730. PY - 1990 SP - 72 EP - 79 VL - 31 IS - 1 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Psychometrics KW - Male KW - Personality Disorders -- diagnosis KW - Personality Tests KW - Anxiety Disorders -- psychology KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Personality Disorders -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79597169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Additional+psychiatric+illness+by+Diagnostic+Interview+Schedule+in+male+alcoholics.&rft.au=Herz%2C+L+R%3BVolicer%2C+L%3BD%27Angelo%2C+N%3BGadish%2C+D&rft.aulast=Herz&rft.aufirst=L&rft.date=1990-01-01&rft.volume=31&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-08 N1 - Date created - 1990-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Medical students as sources of rubella and measles outbreaks. AN - 79594140; 2297297 AB - Medical students demonstrate a high degree of susceptibility to rubella and measles, and hence are at risk for infection and transmission of these viruses. The purpose of our study was to examine the role medical students play as sources or vectors in rubella and measles outbreaks. We conducted a survey of all US and Canadian public health departments to determine how often students were implicated in outbreaks (response rate, 88.7%). We also performed a literature search to identify any cases not reported to health departments, as well as examined the medical, social, and economic consequences of such outbreaks in the medical setting. Since 1981, 9% of health departments have recorded at least one outbreak of rubella or measles in which medical students were specifically implicated as sources or vectors. Increased morbidity, mortality, and adverse economic consequences resulted from these outbreaks. Our data confirm that medical students are important sources/vectors in rubella and measles outbreaks. We recommend that all medical students be immune to these viruses. JF - Archives of internal medicine AU - Poland, G A AU - Nichol, K L AD - Veterans Administration Medical Center/University of Minnesota, Minneapolis. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 44 EP - 46 VL - 150 IS - 1 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Canada -- epidemiology KW - Risk Factors KW - Humans KW - Data Collection KW - United States -- epidemiology KW - Measles -- transmission KW - Students, Medical KW - Rubella -- transmission KW - Occupational Diseases -- epidemiology KW - Disease Outbreaks KW - Rubella -- epidemiology KW - Measles -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79594140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Medical+students+as+sources+of+rubella+and+measles+outbreaks.&rft.au=Poland%2C+G+A%3BNichol%2C+K+L&rft.aulast=Poland&rft.aufirst=G&rft.date=1990-01-01&rft.volume=150&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-12 N1 - Date created - 1990-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1990 Jan;150(1):25-6 [2297294] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - ADP and glucose as possible synergistic partners in the stimulation of liver glycogen synthase activation. AN - 79589963; 2105077 AB - Glucose administered either intravenously or orally causes liver glycogen synthase activation independent of a rise in circulating insulin. In vitro, physiological concentrations of glucose stimulate synthase phosphatase activity but only in the presence of a second effector which reduced the A0.5 for glucose. Caffeine and certain methylxanthines have been in vitro models for a putative natural effector. The present study demonstrates that, in vitro, ADP also reduced the A0.5 for glucose comparable to the effect of caffeine. The maximum stimulation by glucose in the presence of caffeine or ADP was comparable. The effect of ADP was specific among the major nucleoside diphosphates. However, the A0.5 for ADP was greater than the normal liver concentration which does not change in response to either glucose or insulin administration. The effect of ADP appeared distinct from that of the methylxanthines since it was observed that at near saturating concentrations of ADP and of glucose, stimulation was increased by addition of theophylline. Similarly, addition of adenosine, a natural cell constituent, caused increased stimulation. Subsequently, it was shown that adenosine reduced the A0.5 for ADP to a nearly physiological concentration. Thus, while ADP is not the inducible putative effector which has been predicted it may be part of an intracellular amplification system for glycogen synthase activation which increases the sensitivity to an induced effector. The present work suggests that the effective concentration of the natural ligand may be less than originally anticipated. This work also suggests that the putative effector could be structurally related to adenosine. Phosphorylase phosphatase activity known to be stimulated by ADP and glucose is further stimulated by the combination which may be acting in synergy. JF - Archives of biochemistry and biophysics AU - Gilboe, D P AD - Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 109 EP - 115 VL - 276 IS - 1 SN - 0003-9861, 0003-9861 KW - Guanosine Diphosphate KW - 146-91-8 KW - Uridine Diphosphate KW - 58-98-0 KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - Cytidine Diphosphate KW - 63-38-7 KW - Theophylline KW - C137DTR5RG KW - Glycogen Synthase KW - EC 2.4.1.11 KW - Glycogen-Synthase-D Phosphatase KW - EC 3.1.3.42 KW - Glucose KW - IY9XDZ35W2 KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Glycogen-Synthase-D Phosphatase -- metabolism KW - Uridine Diphosphate -- pharmacology KW - Guanosine Diphosphate -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Adenosine -- pharmacology KW - Theophylline -- pharmacology KW - Kinetics KW - Cytidine Diphosphate -- pharmacology KW - Drug Synergism KW - Male KW - Liver -- enzymology KW - Glycogen Synthase -- metabolism KW - Glucose -- pharmacology KW - Adenosine Diphosphate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79589963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=ADP+and+glucose+as+possible+synergistic+partners+in+the+stimulation+of+liver+glycogen+synthase+activation.&rft.au=Gilboe%2C+D+P&rft.aulast=Gilboe&rft.aufirst=D&rft.date=1990-01-01&rft.volume=276&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-21 N1 - Date created - 1990-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incorporating severity of illness into estimates of likelihood ratios. AN - 79589461; 2296996 AB - Although severity of illness may affect the usefulness of a diagnostic test, most previous work has considered test performance only in the dichotomous situation where the target disorder is considered present or absent. In this paper, a clinical example is provided and two methods presented whereby illness severity may be incorporated into the determination of likelihood ratios for a diagnostic test. The use of this approach is that given a test result, a clinician may determine the post-test probability of all levels of the illness in the patient under study. JF - The American journal of the medical sciences AU - Lichtenstein, M AU - Kiefe, C AD - Audie Murphy Memorial Veterans Administration Hospital, University of Texas Health Science Center, San Antonio. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 38 EP - 42 VL - 299 IS - 1 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Probability KW - Humans KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Alcoholism -- physiopathology KW - Erythrocyte Indices KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79589461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Incorporating+severity+of+illness+into+estimates+of+likelihood+ratios.&rft.au=Lichtenstein%2C+M%3BKiefe%2C+C&rft.aulast=Lichtenstein&rft.aufirst=M&rft.date=1990-01-01&rft.volume=299&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-22 N1 - Date created - 1990-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence of human immunodeficiency virus and hepatitis B virus in unselected hospital admissions: implications for mandatory testing and universal precautions. AN - 79543605; 2295847 AB - The prevalence of human immunodeficiency virus (HIV) and hepatitis B virus in serial unselected hospital admissions was determined to examine the potential efficacy of a system of universal blood and body fluid precautions versus a system based on selected or unselected screening. Serum was obtained from 616 (97%) of the 636 patients admitted during a 1-month period and interviews were completed on 540. Of the 616, 23 (3.7%) were confirmed positive for HIV, and 12 (2.0%) of 612 for hepatitis B surface antigen. Of 33 infected persons, only 8 were known to be positive on admission and only 22 were in "high-risk" groups; therefore, selective precautions would not have been effective. Mandatory testing would have required 1216 tests to identify 25 infected persons and would leave in doubt the presence of other transmissible diseases. On the basis of these data, it appears that universal precautions are a logical system of infection control. JF - The Journal of infectious diseases AU - Gordin, F M AU - Gibert, C AU - Hawley, H P AU - Willoughby, A AD - Medicine Service, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 14 EP - 17 VL - 161 IS - 1 SN - 0022-1899, 0022-1899 KW - HIV Antigens KW - 0 KW - Hepatitis B Antigens KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Hepatitis B Antigens -- blood KW - Communicable Disease Control -- methods KW - Personnel, Hospital KW - Risk Factors KW - Humans KW - Safety KW - Occupational Diseases -- prevention & control KW - HIV Antigens -- blood KW - Male KW - Female KW - Prevalence KW - HIV Seropositivity -- diagnosis KW - Hepatitis B virus -- isolation & purification KW - HIV -- isolation & purification KW - HIV Seropositivity -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79543605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Prevalence+of+human+immunodeficiency+virus+and+hepatitis+B+virus+in+unselected+hospital+admissions%3A+implications+for+mandatory+testing+and+universal+precautions.&rft.au=Gordin%2C+F+M%3BGibert%2C+C%3BHawley%2C+H+P%3BWilloughby%2C+A&rft.aulast=Gordin&rft.aufirst=F&rft.date=1990-01-01&rft.volume=161&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-13 N1 - Date created - 1990-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production. AN - 79537346; 2104626 AB - In normal men, chronic testosterone (T) administration results in negative feedback suppression of gonadotropin and sperm production. However, azoospermia is achieved in only 50-70% of men treated with high dosages of T. Furthermore, the relative sensitivity of LH and FSH secretion to chronic administration of more physiological dosages of T is unclear. We determined whether a T dosage higher than those previously given would be more or less effective in suppressing spermatogenesis and whether, within the physiological range, T would exert a more selective effect on LH than on FSH secretion. After a 4- to 6-month control period, 51 normal men were randomly assigned to treatment groups (n = 9-12/group) receiving either sesame oil (1 mL) or T enanthate (25, 50, 100, or 300 mg, im) weekly for 6 months. Monthly LH and FSH levels by RIA and twice monthly sperm counts were determined. During treatment, T levels were measured daily between two weekly injections. Chronic T administration in physiological to moderately supraphysiological dosages resulted in parallel dose-dependent suppression of LH, FSH, and sperm production. T enanthate (50 mg/week) suppressed LH and FSH levels and sperm counts to 50% of those in placebo-treated men (ED50). T enanthate (300 mg/week), was no more effective than 100 mg/week in suppressing LH, FSH, and sperm production. Serum T levels in men who received 100 and 300 mg/week T enanthate were 1.5- and 3-fold higher than those in placebo-treated men, respectively. Except for mild truncal acne, weight gain, and increases in hematocrit, we detected no significant adverse health effects of chronic high dosage T administration. We conclude that 1) LH and FSH secretion are equally sensitive to the long term negative feedback effects of T administration; 2) sperm production is suppressed in parallel with the LH and FSH reductions induced by chronic T administration; and 3) even at the clearly supraphysiological dosage of 300 mg/week, T enanthate does not reliably induce azoospermia in normal men. However, there was also no evidence of a stimulatory effect of this T dosage on spermatogenesis. Furthermore, we found no evidence of major adverse health effects of T administered chronically even at the highest dosage. JF - The Journal of clinical endocrinology and metabolism AU - Matsumoto, A M AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 282 EP - 287 VL - 70 IS - 1 SN - 0021-972X, 0021-972X KW - Testosterone KW - 3XMK78S47O KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Abridged Index Medicus KW - Index Medicus KW - Population KW - United States KW - Research Methodology KW - Contraceptive Agents KW - Physiology KW - Evaluation Methodology KW - Contraceptive Agents, Male KW - Hormones KW - Developed Countries KW - Evaluation KW - Testosterone--administraction and dosage KW - Follicle Stimulating Hormone--men KW - Spermatogenesis Blocking Agents KW - Feedback KW - Family Planning KW - North America KW - Washington KW - Americas KW - Gonadotropins KW - Endocrine System KW - Research Report KW - Studies KW - Clinical Trials KW - Case Control Studies KW - Northern America KW - Luteinizing Hormone--men KW - Contraception KW - Gonadotropins, Pituitary KW - Clinical Research KW - Biology KW - Androgens KW - Drug Tolerance KW - Sperm Count -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Male KW - Testosterone -- administration & dosage KW - Testosterone -- adverse effects KW - Luteinizing Hormone -- blood KW - Spermatogenesis -- drug effects KW - Follicle Stimulating Hormone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79537346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Effects+of+chronic+testosterone+administration+in+normal+men%3A+safety+and+efficacy+of+high+dosage+testosterone+and+parallel+dose-dependent+suppression+of+luteinizing+hormone%2C+follicle-stimulating+hormone%2C+and+sperm+production.&rft.au=Matsumoto%2C+A+M&rft.aulast=Matsumoto&rft.aufirst=A&rft.date=1990-01-01&rft.volume=70&rft.issue=1&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-29 N1 - Date created - 1990-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Volume depletion in a patient with cirrhosis. AN - 79535324; 2294740 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Graber, M AD - Department of Medicine, Veterans Administration Medical Center, Northport, NY 11768. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 89 EP - 92 VL - 15 IS - 1 SN - 0272-6386, 0272-6386 KW - Index Medicus KW - Ascites -- etiology KW - Hypotension, Orthostatic -- etiology KW - Humans KW - Adult KW - Acute Kidney Injury -- etiology KW - Male KW - Liver Cirrhosis, Alcoholic -- complications KW - Dehydration -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79535324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Volume+depletion+in+a+patient+with+cirrhosis.&rft.au=Graber%2C+M&rft.aulast=Graber&rft.aufirst=M&rft.date=1990-01-01&rft.volume=15&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-06 N1 - Date created - 1990-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism and disposition of benzidine in the dog. AN - 79531650; 2403856 AB - The dog is an animal model for assessing aromatic amine-induced bladder cancer. For this reason, metabolism and disposition of benzidine in dog was assessed. Dogs were administered a 1 mg/kg i.v. dose of [3H]benzidine (16.4 mCi/mmol). The plasma t1/2 of the radiolabeled material (benzidine plus metabolites) was significantly longer (approximately 3 h) than authentic benzidine (less than 30 min). During the 5 h experiment, the majority of radiolabel was associated with bile, urine and carcass. Bladder transitional epithelium exhibited a consistently higher concentration of bound radioactivity than bladder muscle. A significant amount of binding was observed in DNA from liver, kidney and bladder. DNA from bladder transitional epithelium exhibited the highest concentration of radioactivity. Approximately 30% of the radioactivity recovered following HPLC of urine or bile was identified as unmetabolized benzidine. 3-Hydroxybenzidine was a major metabolite identified in bile (8%) but not urine. Urine samples treated with acid, base or sulfatase yielded 3-hydroxybenzidine (6%) as a major hydrolysis product. Similar treatment of bile samples did not result in increased amounts of 3-hydroxybenzidine. Neither N-acetylated nor N-methylated metabolites of benzidine were observed in urine or bile. Thus, considerable metabolism of benzidine occurs in dogs by pathways that are yet to be determined. JF - Carcinogenesis AU - Lakshmi, V M AU - Mattammal, M B AU - Spry, L A AU - Kadlubar, F F AU - Zenser, T V AU - Davis, B B AD - Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Medical Center, St Louis, MO 63125. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 139 EP - 144 VL - 11 IS - 1 SN - 0143-3334, 0143-3334 KW - Benzidines KW - 0 KW - Tritium KW - 10028-17-8 KW - benzidine KW - 2X02101HVF KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Half-Life KW - Biotransformation KW - DNA -- metabolism KW - Dogs KW - Radioisotope Dilution Technique KW - Bile -- metabolism KW - Tissue Distribution KW - Female KW - Chromatography, High Pressure Liquid KW - Benzidines -- metabolism KW - Benzidines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79531650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolism+and+disposition+of+benzidine+in+the+dog.&rft.au=Lakshmi%2C+V+M%3BMattammal%2C+M+B%3BSpry%2C+L+A%3BKadlubar%2C+F+F%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Lakshmi&rft.aufirst=V&rft.date=1990-01-01&rft.volume=11&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-22 N1 - Date created - 1990-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy. AN - 79531186; 2293580 AB - Topical 20% benzocaine (Hurricaine, Beutlich, Inc., Niles, Ill.) spray is frequently used for oral anesthesia before upper endoscopy. Side effects attributed to this agent are exceedingly rare. The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase deficiency. The mechanisms for the development of methemoglobinemia and its treatment are reviewed. JF - Gastroenterology AU - Collins, J F AD - Portland Veterans Administration Medical Center, Oregon. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 211 EP - 213 VL - 98 IS - 1 SN - 0016-5085, 0016-5085 KW - Cytochrome-B(5) Reductase KW - EC 1.6.2.2 KW - Benzocaine KW - U3RSY48JW5 KW - Abridged Index Medicus KW - Index Medicus KW - Gastroscopy KW - Humans KW - Adult KW - Male KW - Cytochrome-B(5) Reductase -- deficiency KW - Anesthesia, Local KW - Benzocaine -- adverse effects KW - Methemoglobinemia -- genetics KW - Methemoglobinemia -- chemically induced KW - Benzocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79531186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Methemoglobinemia+as+a+complication+of+20%25+benzocaine+spray+for+endoscopy.&rft.au=Collins%2C+J+F&rft.aulast=Collins&rft.aufirst=J&rft.date=1990-01-01&rft.volume=98&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-16 N1 - Date created - 1990-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic increases in IL-1 synthesis by the human monocytic cell line THP-1 treated with PAF and endotoxin. AN - 79528254; 2293896 AB - The capacity to stimulate cytokine release may be important to the long-term effects of platelet-activating factor (PAF), which has a very short half-life. Previous studies have shown that PAF stimulates interleukin 1 (IL-1) release by human monocytes. IL-1 and other cytokines produced in response to PAF may be important to the long-term effects of this short-lived lipid. The THP-1 human monocytic leukemia cell line, was used to study the mechanism by which PAF stimulates IL-1 release. PAF stimulates the release of IL-1 beta activity into THP-1 cell supernatants with a multiphasic dose-response curve very similar to that for monocytes. When THP-1 cells are treated with PAF and LPS in combination, these two stimuli interact synergistically to greatly increase the release of IL-1 activity. To assess the effect of PAF on IL-1 beta synthesis, THP-1 cell pellet proteins were separated by SDS-PAGE, blotted, and immunostained to detect IL-1 beta. Immunostaining revealed that PAF increases intracellular IL-1 beta precursor and that the combination of PAF and LPS increases IL-1 beta precursor synergistically. PAF increases IL-1 beta release mainly by increasing IL-1 beta synthesis. JF - Cellular immunology AU - Barthelson, R A AU - Potter, T AU - Valone, F H AD - Department of Medicine, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 142 EP - 150 VL - 125 IS - 1 SN - 0008-8749, 0008-8749 KW - Endotoxins KW - 0 KW - Interleukin-1 KW - Lipopolysaccharides KW - Platelet Activating Factor KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Blotting, Western KW - Dinoprostone -- biosynthesis KW - Dose-Response Relationship, Drug KW - Lipopolysaccharides -- pharmacology KW - Humans KW - In Vitro Techniques KW - Drug Synergism KW - Cell Line KW - Platelet Activating Factor -- pharmacology KW - Interleukin-1 -- biosynthesis KW - Monocytes -- metabolism KW - Endotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79528254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Synergistic+increases+in+IL-1+synthesis+by+the+human+monocytic+cell+line+THP-1+treated+with+PAF+and+endotoxin.&rft.au=Barthelson%2C+R+A%3BPotter%2C+T%3BValone%2C+F+H&rft.aulast=Barthelson&rft.aufirst=R&rft.date=1990-01-01&rft.volume=125&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-08 N1 - Date created - 1990-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - CPAPER T1 - Aging, Socioeconomic Development, and Aging Policy in Iceland T2 - International Sociological Association AN - 61715737; 90S23731 AB - Iceland presents an unusual case of an industrialized Western society having undergone both demographic transition & socioeconomic development recently & rapidly. Demographic changes are pressing increasing levels of need & demand on formal & informal geriatric services. With industrialization & attendant development has come a transformation in the relationship between basic cultural values embodied in the idea of the individual (emphasizing disparate themes of personal responsibility & obligation, autonomy, & independence) & notions of collective rights & obligations associated with increasing social stratification. These changes are explored in relation to the current & planned system of geriatric services. Discussion will address the future balance of public & private financing, & formal & informal caregiving. It is expected that broad support will remain for public services & financing, & that policy will continue to be sensitive to the capabilities & preferences of elderly Icelanders & their families. JF - International Sociological Association AU - Wieland, Darryl Y1 - 1990///0, PY - 1990 DA - 0, 1990 KW - geriatric services/policy, Iceland KW - Social Services KW - Elderly KW - Health Policy KW - Iceland KW - proceeding KW - 2143: social problems and social welfare; social gerontology KW - 0715: social change and economic development; social change & economic development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61715737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=Aging%2C+Socioeconomic+Development%2C+and+Aging+Policy+in+Iceland&rft.au=Wieland%2C+Darryl&rft.aulast=Wieland&rft.aufirst=Darryl&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1990 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Introduction: Assessment and Treatment Strategies with the Late Life Alcoholic AN - 61656098; 199102129 AB - An overview of the prevalence, clinical course, & treatment issues relevant to older alcoholics. Identification of men & women in their 60s & beyond who have significant alcohol-related life impairment presents a clinical challenge. Once the diagnosis is established, however, the treatment follows the general approach used in younger individuals, with extra attention to health problems, the unique place in the family structure occupied by older patients, & the need to coordinate care from clinics & other treatment settings. AA JF - Journal of Geriatric Psychiatry AU - Schuckit, Marc A AD - Dept Psychiatry 116A San Diego Veterans Administration Hospital, La Jolla CA 92161 Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 83 EP - 89 VL - 23 IS - 2 SN - 0022-1414, 0022-1414 KW - older alcoholics, prevalence/clinical course/treatment issues KW - Epidemiology KW - Alcoholism KW - Elderly KW - Treatment Methods KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61656098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geriatric+Psychiatry&rft.atitle=Introduction%3A+Assessment+and+Treatment+Strategies+with+the+Late+Life+Alcoholic&rft.au=Schuckit%2C+Marc+A&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1990-01-01&rft.volume=23&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geriatric+Psychiatry&rft.issn=00221414&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Alcoholism; Treatment Methods; Epidemiology ER - TY - JOUR T1 - Family Counseling with Elders: A Useful and Positive Starting Point AN - 61577818; 199000781 AB - The process of family counseling with elders is described, presenting an approach that attempts to solve problems associated with aging by viewing them in relation to the elder's social support (interactional) system. Addressed are common presenting problems, how to approach families with elders, conditions of doing family counseling with elders, the process of family problem solving, & strengths & limitations of this therapeutic approach. 6 References. AA JF - Generations AU - Florsheim, Margaret J AU - Herr, John J AD - Older Adult & Family Research & Resource Center Palo Alto Veterans Administration Medical Center, CA 94303 Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 40 EP - 42 VL - 14 IS - 1 SN - 0738-7806, 0738-7806 KW - family counseling process with elders, therapeutic approach KW - Family Therapy KW - Elderly KW - Counseling KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61577818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Generations&rft.atitle=Family+Counseling+with+Elders%3A+A+Useful+and+Positive+Starting+Point&rft.au=Florsheim%2C+Margaret+J%3BHerr%2C+John+J&rft.aulast=Florsheim&rft.aufirst=Margaret&rft.date=1990-01-01&rft.volume=14&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Generations&rft.issn=07387806&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Counseling; Family Therapy; Elderly ER - TY - JOUR T1 - The Severely Disturbed Adolescent: Indications for Hospital and Residential Treatment AN - 61549878; 199001948 AB - Certain groups of preadolescent & adolescent children suffer from developmental & adaptive problems serious enough that they become candidates for full-time hospital or residential treatment. The diagnostic criteria that justify such placement are reviewed & typical characteristics of these children & adolescents are described, with particular attention to borderline & narcissistic personality disorders. The need for a psychodynamic, rather than a merely symptom-focused, approach to milieu treatment is emphasized. 76 References. HA JF - Bulletin of the Menninger Clinic AU - Rinsley, Donald B AD - Psychiatry Service Colmery-O'Neil Veterans Administration Medical Center, 2200 Gage Blvd Topeka KS 66622 Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 3 EP - 12 VL - 54 IS - 1 SN - 0025-9284, 0025-9284 KW - severely disturbed children/adolescents, hospitalization/residential treatment need assessment, diagnostic criteria KW - Emotionally Disturbed KW - Diagnosis KW - Treatment Programs KW - Hospitalization KW - Residential Institutions KW - Children KW - Adolescents KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61549878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Menninger+Clinic&rft.atitle=The+Severely+Disturbed+Adolescent%3A+Indications+for+Hospital+and+Residential+Treatment&rft.au=Rinsley%2C+Donald+B&rft.aulast=Rinsley&rft.aufirst=Donald&rft.date=1990-01-01&rft.volume=54&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Menninger+Clinic&rft.issn=00259284&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Adolescents; Children; Emotionally Disturbed; Hospitalization; Residential Institutions; Diagnosis; Treatment Programs ER - TY - JOUR T1 - The Discharge Issues Group: A Model for Acute Psychiatric Inpatient Units AN - 61468011; 199000086 AB - Following a review of the literature (1975-1985) on discharge from inpatient psychiatric hospitals, focusing on group work used to prepare patients to reenter the world at large, presented is an alternative model, the discharge issues group, which allows patients to express their feelings about leaving the hospital. Two case examples are cited to illustrate how the group functions. 8 References. Modified AA JF - Social Work with Groups AU - Armstrong, Keith AD - Veterans Administration Medical Center, 4150 Clement St San Francisco CA 94121 Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 93 EP - 101 VL - 13 IS - 1 SN - 0160-9513, 0160-9513 KW - psychiatric hospital inpatients, discharge preparation, group work model KW - literature review, case examples KW - Discharge KW - Mental Patients KW - Group Work KW - Mental Hospitals KW - Treatment Methods KW - Models KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61468011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+with+Groups&rft.atitle=The+Discharge+Issues+Group%3A+A+Model+for+Acute+Psychiatric+Inpatient+Units&rft.au=Armstrong%2C+Keith&rft.aulast=Armstrong&rft.aufirst=Keith&rft.date=1990-01-01&rft.volume=13&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Social+Work+with+Groups&rft.issn=01609513&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Patients; Mental Hospitals; Discharge; Group Work; Treatment Methods; Models ER - TY - JOUR T1 - Subsistence Adaptation among Homeless Adults in the Inner City of Los Angeles AN - 61250985; 91Y0103 AB - The subsistence-related activities of English-speaking homeless adults (N = 328) in the downtown area of Los Angeles, Calif, are described, drawing on interview data, with focus on whether homeless people with chronic disorders, eg, major mental illness &/or substance abuse, differ from those with no chronic disorder in their subsistence adaptation. Findings indicate that homeless people use multiple resources over short periods of time. While minor differences between those with & without disorders were apparent, the general lack of differences between these two groups was most striking, suggesting the leveling quality of homelessness. Differences between individuals with various chronic disorders indicated that those with chronic substance abuse, & particularly those with both substance abuse & chronic mental illness, were most distinctive in their adaptation. 6 Tables, 30 References. Adapted from the source document. JF - The Journal of Social Issues AU - Koegel, Paul AU - Burnam, M Audrey AU - Farr, Rodger K AD - Brentwood Veterans Administration Medical Center, Wilshire & Sawtelle Blvds Los Angeles CA 90073 Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 83 EP - 107 VL - 46 IS - 4 SN - 0022-4537, 0022-4537 KW - subsistence-related activities, homeless adults KW - Los Angeles, California KW - chronic disorders KW - interview data KW - Substance Abuse KW - Mental Illness KW - Illness KW - Drug Abuse KW - Homelessness KW - article KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61250985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Social+Issues&rft.atitle=Subsistence+Adaptation+among+Homeless+Adults+in+the+Inner+City+of+Los+Angeles&rft.au=Koegel%2C+Paul%3BBurnam%2C+M+Audrey%3BFarr%2C+Rodger+K&rft.aulast=Koegel&rft.aufirst=Paul&rft.date=1990-01-01&rft.volume=46&rft.issue=4&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Social+Issues&rft.issn=00224537&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSISAF N1 - SubjectsTermNotLitGenreText - Homelessness; Los Angeles, California; Illness; Drug Abuse; Substance Abuse; Mental Illness ER - TY - JOUR T1 - Coping and Appraisal in Potential Relapse Situations among Adolescent Substance Abusers following Treatment AN - 61247524; 91X5544 AB - An investigation of coping of teenage substance abusers at high risk for relapse, based on questionnaire data collected from 50 adolescents, 2 weeks & 6 months following their release from a residential treatment program in San Diego, Calif. It was predicted that abstainers & relapsers would have similar responses for self-generated situations in which they all abstained, while relapsers would appraise hypothetical relapse situation as more stressful & endorse fewer coping stategies than abstainers. Results largely confirmed prediction, showing no coping differences among outcome groups for successful abstinence situations, while abstainers & minor relapsers endorsed more problem-focused coping strategies than major relapsers for hypothetical high risk situations. 4 Tables, 31 References. Adapted from the source document. JF - Journal of Adolescent Chemical Dependency AU - Myers, Mark G AU - Brown, Sandra A AD - c/o Brown -- Dept Psychiatry Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 95 EP - 115 VL - 1 IS - 2 SN - 0896-7768, 0896-7768 KW - posttreatment relapse, teenage substance abusers KW - coping responses KW - questionnaire data KW - San Diego, California KW - Substance Abuse KW - Coping KW - Adolescents KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61247524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Chemical+Dependency&rft.atitle=Coping+and+Appraisal+in+Potential+Relapse+Situations+among+Adolescent+Substance+Abusers+following+Treatment&rft.au=Myers%2C+Mark+G%3BBrown%2C+Sandra+A&rft.aulast=Myers&rft.aufirst=Mark&rft.date=1990-01-01&rft.volume=1&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Chemical+Dependency&rft.issn=08967768&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JACDEM N1 - SubjectsTermNotLitGenreText - Substance Abuse; Adolescents; Coping; San Diego, California ER - TY - JOUR T1 - Meeting Production: The Economics of Contracting Mental Illness AN - 61228693; 91X3288 AB - An ethnographic case study is presented to illustrate the impact of economic forces on organizational structure & clinical practice, drawing on research conducted 1984-1986 at Harbor House, a day treatment program serving the long-term mentally ill in a suburb of Los Angeles, Calif. Of the two main types of services, habilitative services receive greater funding than socialization services because they are aimed at clients requiring the highest levels of care. Sources of funding & requirements are described & related to the facility's two ideological models: clubhouse (rehabilitation) & treatment. While the former allows staff & clients more flexibility & interaction, treatment must be justified in order to receive Medi-Cal funding, causing great stress for staff, who attempt to provide clients with the kind of care they need, regardless of whether this is reflected in production quotas. The efforts of staff to conform to constantly changing funding requirements & paperwork frequently put them in a double-bind situation where care is manipulated to gain funding, leading to frustration & burnout, & adversely affecting staff morale & patient treatment. 2 Tables, 27 References. S. Dilts JF - Social Science and Medicine AU - Baldwin, Dana M AD - Dept Psychiatry Brentwood Veterans Administration Medical Center (B117), Los Angeles CA 90073 Y1 - 1990///0, PY - 1990 DA - 0, 1990 SP - 961 EP - 968 VL - 30 IS - 9 SN - 0277-9536, 0277-9536 KW - organizational structure/clinical practice, mentally ill treatment program, Los Angeles, California KW - economic forces KW - ethnographic case study KW - Economic Factors KW - Los Angeles, California KW - Mental Patients KW - Treatment Programs KW - Organizational Structure KW - Mental Illness KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61228693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=Meeting+Production%3A+The+Economics+of+Contracting+Mental+Illness&rft.au=Baldwin%2C+Dana+M&rft.aulast=Baldwin&rft.aufirst=Dana&rft.date=1990-01-01&rft.volume=30&rft.issue=9&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Mental Illness; Organizational Structure; Treatment Programs; Los Angeles, California; Mental Patients; Economic Factors ER - TY - JOUR T1 - Modified criteria for the objective diagnosis of chronic compartment syndrome of the leg AN - 20067165; 10093375 AB - One hundred fifty-nine patients were referred to the authors for evaluation of chronic exertional leg pain from 1978 to 1987. The records of 131 patients were complete and available for retrospective review. Forty- five patients were diagnosed as having a chronic com partment syndrome (CCS) and seventy-five patients had the syndrome ruled out by intramuscular pressure recordings. The only significant difference found be tween the two groups on history and physical exami nation was a 45.9% incidence of muscle herniae in the patients with CCS, compared to a 12.9% incidence in those without the syndrome. One-third of the patients with the syndrome and over one-half of those without it reported persistent, moderate to severe pain at 6 month to 9 year followup.Modified, objective criteria were developed for the diagnosis of CCS. The criteria were based upon the intramuscular pressures recorded with the slit catheter before and after exercise in 210 muscle compartments without CCS. In the presence of appropriate clinical findings, we consider one or more of the following intramuscular pressure criteria to be diagnostic of chronic compartment syndrome of the leg: 1) a preex ercise pressure greater than or equal to 15 mm Hg, 2) a 1 minute postexercise pressure of greater than or equal to 30 mm Hg, or 3) a 5 minute postexercise pressure greater than or equal to 20 mm Hg. JF - American Journal of Sports Medicine AU - Pedowitz, Robert A AU - Hargens, Alan R AU - Mubarak, Scott J AU - Gershuni, David H AD - Division of Orthopaedics and Rehabilitation, University of California, and the Veterans Administration Medical Center, San Diego, California Y1 - 1990/01// PY - 1990 DA - Jan 1990 SP - 35 EP - 40 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 18 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Evaluation KW - Muscles (exercise effects) KW - Objectives KW - Muscles KW - Stress KW - Patients KW - Legs KW - Pain KW - Compartment syndrome KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20067165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Modified+criteria+for+the+objective+diagnosis+of+chronic+compartment+syndrome+of+the+leg&rft.au=Pedowitz%2C+Robert+A%3BHargens%2C+Alan+R%3BMubarak%2C+Scott+J%3BGershuni%2C+David+H&rft.aulast=Pedowitz&rft.aufirst=Robert&rft.date=1990-01-01&rft.volume=18&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354659001800106 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Evaluation; Muscles (exercise effects); Objectives; Muscles; Stress; Pain; Legs; Patients; Compartment syndrome DO - http://dx.doi.org/10.1177/036354659001800106 ER - TY - JOUR T1 - Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats. AN - 16420368; 2901993 AB - Acetaminophen is metabolized by cytochrome P450 to N-acetyl-p-benzoquinone imine (NABQI). This metabolite reacts with critical cellular macromolecules to give toxicity. The administration of 10% ethanol in the drinking water to 100 g male rats for 6 weeks markedly increases the toxicity of acetaminophen. This increase was associated with a 71% increase in microsomal protein binding of acetaminophen (4.8 pmol/min/mg protein in control microsomes versus 8.2 pmol/min/mg protein in ethanol microsomes (P < 0.01)) and a 131% increase in aniline hydroxylase (0.52 nmol/min/mg protein in control microsomes versus 1.20 nmol/min/mg protein in ethanol microsomes (P < 0.001)). JF - Biochemical Pharmacology AU - Siva Prasad, J AU - Chen, Neng Qain AU - Liu, Yu Xiu AU - Goon, DJW AU - Holtzman, J L AD - Dep. Pharmacol., Veterans Administration Med. Cent., One Veterans Dr., Minneapolis, MN 55417, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 1989 EP - 1995 VL - 40 IS - 9 SN - 0006-2952, 0006-2952 KW - ethanol KW - N-acetyl-p-benzoquinone imine KW - effects on KW - rats KW - acetaminophen KW - binding KW - liver KW - metabolism KW - microsomes KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16420368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Effects+of+ethanol+and+inhibitors+on+the+binding+and+metabolism+of+acetaminophen+and+N-acetyl-p-benzoquinone+imine+by+hepatic+microsomes+from+control+and+ethanol-treated+rats.&rft.au=Siva+Prasad%2C+J%3BChen%2C+Neng+Qain%3BLiu%2C+Yu+Xiu%3BGoon%2C+DJW%3BHoltzman%2C+J+L&rft.aulast=Siva+Prasad&rft.aufirst=J&rft.date=1990-01-01&rft.volume=40&rft.issue=9&rft.spage=1989&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - metabolism; binding; microsomes; liver ER - TY - JOUR T1 - Effects of high-dose methamphetamine administration on serotonin uptake sites in rat brain measured using [3H]cyanoimipramine autoradiography. AN - 79433527; 2611665 AB - Repeated administration of high doses of methamphetamine (15 mg/kg given for 5 doses over 24 h) resulted in long-term decreases in the binding of [3H]cyanoimipramine ([3H]CN-IMI) to serotonin uptake sites measured using quantitative autoradiography. Seven days after termination of drug administration decreases were seen in 23 of 28 regions examined. This is consistent with previous studies indicating that methamphetamine and related amphetamines are neurotoxic to serotonin neurons. Significant decreases were still present in many brain areas on the same dosage schedule 30 days after drug administration. However, the number of areas affected was considerably less, consistent with some regrowth of serotonin neurons. At a lower dosage (7.5 mg/kg on the same schedule) no effects on [3H]CN-IMI binding were seen. The results of this study provide support for the serotonergic neurotoxicity of repeated methamphetamine administration in rats. They also show that the neurotoxicity is highly regional and dose dependent. JF - Brain research AU - Kovachich, G B AU - Aronson, C E AU - Brunswick, D J AD - Neuropsychopharmacology Unit, Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1989/12/25/ PY - 1989 DA - 1989 Dec 25 SP - 123 EP - 129 VL - 505 IS - 1 SN - 0006-8993, 0006-8993 KW - Receptors, Serotonin KW - 0 KW - Serotonin Antagonists KW - cianopramine KW - 02MNR4P2PM KW - Methamphetamine KW - 44RAL3456C KW - Imipramine KW - OGG85SX4E4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Male KW - Imipramine -- analogs & derivatives KW - Brain -- drug effects KW - Methamphetamine -- pharmacology KW - Imipramine -- metabolism KW - Brain -- metabolism KW - Receptors, Serotonin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79433527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Effects+of+high-dose+methamphetamine+administration+on+serotonin+uptake+sites+in+rat+brain+measured+using+%5B3H%5Dcyanoimipramine+autoradiography.&rft.au=Kovachich%2C+G+B%3BAronson%2C+C+E%3BBrunswick%2C+D+J&rft.aulast=Kovachich&rft.aufirst=G&rft.date=1989-12-25&rft.volume=505&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-01 N1 - Date created - 1990-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Correlation of chest roentgenograms with pulmonary function and bronchoalveolar lavage in interstitial lung disease. AN - 85251273; pmid-2582825 AB - We used the ILO classification for occupational lung disease to determine whether there was any correlation between the type and/or severity of pulmonary infiltration on chest roentgenograms and either pulmonary function tests or the types of inflammatory cells present in BAL fluid in patients with interstitial lung disease. Of the 62 patients evaluated (27 with sarcoidosis, 18 with IPF, and 17 with a CV disease and lung involvement), 49 had irregular linear opacities and 13 had normal chest x-rays. There were no significant correlations between the types of cells present in BAL fluid and the various categories of infiltrate or profusion of the infiltrates within each disease group. In patients with sarcoidosis, more extensive infiltration (profusion) was associated with lower FEV, (p less than 0.01). In patients with IPE, linear opacity type, profusion, and the presence or absence of honeycombing were not related to the severity of pulmonary function abnormalities. We conclude that the ILO classification for analysis of chest roentgenograms can be applied to patients with interstitial lung disease not associated with an occupational exposure and that this approach is useful, especially for communication. However, these data provide no information regarding the inflammatory process in the lung and limited information regarding abnormalities in pulmonary function. JF - Chest AU - Nugent, K M AU - Peterson, M W AU - Jolles, H AU - Monick, M M AU - Hunninghake, G W AD - Department of Medicine, Veterans Administration Hospital, Iowa City. PY - 1989 SP - 1224 EP - 1227 VL - 96 IS - 6 SN - 0012-3692, 0012-3692 KW - Respiratory Function Tests KW - Human KW - Bronchoalveolar Lavage Fluid KW - Tomography, X-Ray Computed KW - Sarcoidosis KW - Pulmonary Fibrosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85251273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Correlation+of+chest+roentgenograms+with+pulmonary+function+and+bronchoalveolar+lavage+in+interstitial+lung+disease.&rft.au=Nugent%2C+K+M%3BPeterson%2C+M+W%3BJolles%2C+H%3BMonick%2C+M+M%3BHunninghake%2C+G+W&rft.aulast=Nugent&rft.aufirst=K&rft.date=1989-12-01&rft.volume=96&rft.issue=6&rft.spage=1224&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Diuretic therapy and exercise in patients with systemic hypertension. AN - 79507107; 2534412 AB - Twenty patients with uncomplicated systemic hypertension underwent treadmill testing twice during placebo treatment and twice during hydrochlorothiazide treatment. Data were collected at rest, at peak exercise and 10 min after exercise. Serum potassium, magnesium and plasma catecholamines increased significantly with exercise. There was no rebound hypokalaemia during the recovery period. Occasional ventricular premature complexes were recorded in all phases of the study. However, there was no difference in the frequency or complexity of arrhythmias between the placebo and the treatment periods. JF - Journal of hypertension. Supplement : official journal of the International Society of Hypertension AU - Papademetriou, V AU - Notargiacomo, A AU - Freis, E D AD - Veterans Administration, Washington, DC 20422. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - S248 EP - S249 VL - 7 IS - 6 SN - 0952-1178, 0952-1178 KW - Catecholamines KW - 0 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Magnesium KW - I38ZP9992A KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Catecholamines -- blood KW - Arrhythmias, Cardiac -- etiology KW - Magnesium -- blood KW - Double-Blind Method KW - Combined Modality Therapy KW - Humans KW - Cardiomegaly -- therapy KW - Potassium -- blood KW - Middle Aged KW - Cardiomegaly -- complications KW - Cardiomegaly -- blood KW - Hypertension -- complications KW - Hypertension -- blood KW - Exercise Therapy KW - Hydrochlorothiazide -- therapeutic use KW - Hypertension -- therapy KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79507107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hypertension.+Supplement+%3A+official+journal+of+the+International+Society+of+Hypertension&rft.atitle=Diuretic+therapy+and+exercise+in+patients+with+systemic+hypertension.&rft.au=Papademetriou%2C+V%3BNotargiacomo%2C+A%3BFreis%2C+E+D&rft.aulast=Papademetriou&rft.aufirst=V&rft.date=1989-12-01&rft.volume=7&rft.issue=6&rft.spage=S248&rft.isbn=&rft.btitle=&rft.title=Journal+of+hypertension.+Supplement+%3A+official+journal+of+the+International+Society+of+Hypertension&rft.issn=09521178&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-11 N1 - Date created - 1990-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Load induction of cardiac hypertrophy. AN - 79493714; 2483414 AB - We have shown in surgical animal models that increased and decreased cardiac loading results in myocardial hypertrophy and atrophy, respectively. These changes, which are readily reversible upon the restoration of a normal cardiac load, occur without any requirement for neural or circulating intermediary factors. In our current studies we have focused first on an unequivocal demonstration of these same phenomena in a much simpler model consisting of isolated quiescent cardiocytes maintained in serum-free medium and second on an elucidation in isolated papillary muscles of the means by which a change in cardiac load is transduced into a change in cardiac mass. Adherent isolated adult cardiocytes held at their rest length exhibit only a very gradual loss of their differentiated features. In contrast, unloaded cardiocytes in suspension culture immediately cease nuclear RNA synthesis and rapidly come to resemble unloaded cardiac muscle--a cardiocyte cellular analog of cardiac tissue atrophy, while loaded adherent cardiocytes stretched past their rest length respond in terms of synthetic activity characteristic of growth initiation--a cardiocyte cellular analog of cardiac tissue hypertrophy. Both quiescent and contracting papillary muscles exhibit increased synthesis of cardiocyte structural proteins in direct relation to active and/or passive muscle tension. This load-dependent protein synthesis appears to require initial sodium influx through deformation-dependent sarcolemmal cation channels, in a manner analogous to the dependence of mitogen-stimulated growth initiation in a variety of other cell types on initial sodium entry, albeit by a different mechanism. Thus, load variation functions as an independent regulator of cardiac growth in the adult, and sarcolemmal deformation with consequent sodium entry may be an initial direct link between load and growth in the heart. JF - Journal of molecular and cellular cardiology AU - Cooper, G AU - Kent, R L AU - Mann, D L AD - Department of Medicine, Veterans Administration Medical Center, Charleston, SC. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 11 EP - 30 VL - 21 Suppl 5 SN - 0022-2828, 0022-2828 KW - Amanitins KW - 0 KW - Muscle Proteins KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Space life sciences KW - Myocardium -- cytology KW - Animals KW - Myocardial Contraction KW - Amanitins -- pharmacology KW - Stress, Mechanical KW - In Vitro Techniques KW - Heart -- drug effects KW - DNA -- biosynthesis KW - Myocardium -- metabolism KW - Muscle Proteins -- biosynthesis KW - Sodium -- metabolism KW - RNA -- biosynthesis KW - Cardiomegaly -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79493714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+and+cellular+cardiology&rft.atitle=Load+induction+of+cardiac+hypertrophy.&rft.au=Cooper%2C+G%3BKent%2C+R+L%3BMann%2C+D+L&rft.aulast=Cooper&rft.aufirst=G&rft.date=1989-12-01&rft.volume=21+Suppl+5&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+and+cellular+cardiology&rft.issn=00222828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-16 N1 - Date created - 1990-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans. AN - 79475486; 2695329 AB - Cilofungin (LY 121019) is a novel analogue of echinocandin B with potent activity against Candida albicans. The effects of cilofungin on the sterol and cell wall carbohydrate composition of Candida albicans were investigated. Exposure of Candida albicans to cilofungin resulted in a 55-60% decrease in ergosterol and a 4-13% decrease in lanosterol content relative to controls. Carbohydrate analysis revealed a 72-79% decrease in glucan content and no significant decrease in mannan or chitin content relative to controls. These studies suggest that cilofungin specifically inhibits glucan synthesis in Candida albicans and thus may be less toxic to mammalian cells. The effects of cilofungin on sterol composition may be non-specific and will require additional investigation. JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology AU - Pfaller, M AU - Riley, J AU - Koerner, T AD - Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1067 EP - 1070 VL - 8 IS - 12 SN - 0934-9723, 0934-9723 KW - Echinocandins KW - 0 KW - Glucans KW - Mannans KW - Peptides KW - Peptides, Cyclic KW - Chitin KW - 1398-61-4 KW - Lanosterol KW - 1J05Z83K3M KW - cilofungin KW - 8ZJC54A39X KW - Ergosterol KW - Z30RAY509F KW - Index Medicus KW - Carbohydrate Sequence -- drug effects KW - Mannans -- analysis KW - Chitin -- metabolism KW - Glucans -- metabolism KW - Chitin -- analysis KW - Peptides -- pharmacology KW - Mannans -- metabolism KW - Glucans -- analysis KW - Candida albicans -- metabolism KW - Ergosterol -- metabolism KW - Lanosterol -- metabolism KW - Candida albicans -- ultrastructure KW - Lanosterol -- analysis KW - Ergosterol -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79475486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+microbiology+%26+infectious+diseases+%3A+official+publication+of+the+European+Society+of+Clinical+Microbiology&rft.atitle=Effects+of+cilofungin+%28LY121019%29+on+carbohydrate+and+sterol+composition+of+Candida+albicans.&rft.au=Pfaller%2C+M%3BRiley%2C+J%3BKoerner%2C+T&rft.aulast=Pfaller&rft.aufirst=M&rft.date=1989-12-01&rft.volume=8&rft.issue=12&rft.spage=1067&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+microbiology+%26+infectious+diseases+%3A+official+publication+of+the+European+Society+of+Clinical+Microbiology&rft.issn=09349723&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-19 N1 - Date created - 1990-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mini-mental state examination and brain age quotient--short form: relationship and demographic correlates. AN - 79472159; 2622731 AB - Modest intercorrelations between scores on the Mini-Mental State Examination and the Brain Age Quotient were obtained for 30 men in a VA medical program for alcoholic dependency, rs with age and education were small. As the two measures are reasonably different, they may be applied to advantage in studies of behavioral intervention. JF - Perceptual and motor skills AU - Horton, A M AU - Heller, S AU - Anilane, J AU - Puente, A E AD - Alcoholism Section, Veterans Administration Medical Center, Baltimore, MD 21218. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1177 EP - 1178 VL - 69 IS - 3 Pt 2 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - Humans KW - Adult KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Brain Damage, Chronic -- diagnosis KW - Mental Status Schedule KW - Neuropsychological Tests KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79472159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Mini-mental+state+examination+and+brain+age+quotient--short+form%3A+relationship+and+demographic+correlates.&rft.au=Horton%2C+A+M%3BHeller%2C+S%3BAnilane%2C+J%3BPuente%2C+A+E&rft.aulast=Horton&rft.aufirst=A&rft.date=1989-12-01&rft.volume=69&rft.issue=3+Pt+2&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-29 N1 - Date created - 1990-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ganglion cell loss continues during hair cell regeneration. AN - 79440229; 2613569 AB - Hair cells and ganglion cells were counted in young adult quail (Coturnix coturnix) after acoustic trauma at 10, 30, 60 and 90 day survival times. Following sacrifice the basilar papillae, along with the ganglia, were fixed, embedded in plastic and sectioned serially at 100 mu intervals from basal to apical tip. Hair cells and ganglion cells were counted from 3 mu thick sections at each interval. Hair cells were designated as tall or short within the area 30-70% of length from basal tip of the papilla. Both tall and short hair cells were significantly reduced in number 10 days following trauma. Tall hair cells recovered to within 96% of normal after 60-90 days. Short hair cells recovered but to a lesser extent. Ganglion cell loss did not begin until 30 days after trauma and continued without recovery 90 days after trauma. A good correlation was found for position of both types of hair cell loss and position of ganglion cell loss. These results suggest that the initial loss of hair cells, both tall and short, results in retrograde degeneration of neural fibers and ganglion cells. JF - Hearing research AU - Ryals, B M AU - Ten Eyck, B AU - Westbrook, E W AD - Veterans Administration Medical Center, Richmond, Virginia. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 81 EP - 90 VL - 43 IS - 1 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - Hearing Loss, Noise-Induced -- pathology KW - Animals KW - Cell Count KW - Coturnix KW - Cell Survival KW - Ganglia -- pathology KW - Hair Cells, Auditory -- physiology KW - Nerve Regeneration -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79440229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Ganglion+cell+loss+continues+during+hair+cell+regeneration.&rft.au=Ryals%2C+B+M%3BTen+Eyck%2C+B%3BWestbrook%2C+E+W&rft.aulast=Ryals&rft.aufirst=B&rft.date=1989-12-01&rft.volume=43&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of postnatal dexamethasone treatment on development of alveoli in adult rats. AN - 79438461; 2612450 AB - We compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. Judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. Lung volumes in both air- and saline-filled lungs and mean chord length (Lm) were increased, whereas alveolar surface area (Sa) and surface-to-volume ratio (S/V) were diminished in dexamethasone-treated adult rats. These changes were associated with a significant reduction in DNA content and concentration but larger protein/DNA and RNA/DNA ratios in the lungs of treated rats. We conclude that dexamethasone treatment during the critical period of septation in rats impairs alveolar formation, which persists until adulthood and leads to larger and less complex gas-exchange regions. Inhibition of DNA synthesis due to dexamethasone may be responsible for its effects on alveolar development. Larger lung volumes in treated rats are, most likely, related to larger air space dimensions. JF - Experimental lung research AU - Sahebjami, H AU - Domino, M AD - Pulmonary Research Laboratory, Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 961 EP - 973 VL - 15 IS - 6 SN - 0190-2148, 0190-2148 KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Respiratory Function Tests KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Respiratory Mechanics -- drug effects KW - Body Weight -- drug effects KW - Male KW - Organ Size -- drug effects KW - Microscopy, Electron, Scanning KW - Dexamethasone -- toxicity KW - Pulmonary Alveoli -- growth & development KW - Pulmonary Alveoli -- ultrastructure KW - Pulmonary Alveoli -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79438461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Effects+of+postnatal+dexamethasone+treatment+on+development+of+alveoli+in+adult+rats.&rft.au=Sahebjami%2C+H%3BDomino%2C+M&rft.aulast=Sahebjami&rft.aufirst=H&rft.date=1989-12-01&rft.volume=15&rft.issue=6&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of endoperoxide product levels and cyclophosphamide-induced injury by glutathione repletion. AN - 79427577; 2606838 AB - Glutathione is a tripeptide important in a number of diverse cellular functions including enzymatic reactions involved in prostaglandin endoperoxide metabolism. We have previously reported that cyclophosphamide administration to rats results in acute lung injury manifested by increased bronchoalveolar lavage albumin concentrations. In the current study we examine whether cyclophosphamide treatment affects pulmonary glutathione stores or bronchoalveolar endoperoxide metabolic product levels and whether these effects may be related to acute lung injury caused by the drug. We show that cyclophosphamide treatment causes a dose-dependent reduction in pulmonary glutathione stores 4 h after drug administration. In addition, acute lung injury as the result of cyclophosphamide can be abrogated by coadministration of oxothiazolidine carboxylate, an intracellular cysteine delivery system that also reverses pulmonary glutathione depletion induced by cyclophosphamide in our study. Finally, cyclophosphamide treatment reduces prostaglandin E2 concentrations in bronchoalveolar lavage and alveolar macrophage culture supernatant in a dose-dependent fashion and increases bronchoalveolar thromboxane concentrations in low dose-treated animals. These effects are reversed to a variable degree by coadministration of oxothiazolidine carboxylate. Our study suggests in vivo pulmonary arachidonic acid metabolism and cyclophosphamide-induced acute lung injury are modulated by cellular glutathione stores. These findings may have important implications for the treatment of acute lung injury. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Cooper, J A AU - Merrill, W W AD - Pulmonary Section, Veterans Administration Medical Center, Birmingham 35233. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 2316 EP - 2322 VL - 67 IS - 6 SN - 8750-7587, 8750-7587 KW - Prostaglandin Endoperoxides KW - 0 KW - Thiazoles KW - Thiazolidines KW - Cyclophosphamide KW - 8N3DW7272P KW - Glutathione KW - GAN16C9B8O KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - 2-oxothiazolidine-4-carboxylic acid KW - X7063P804E KW - Index Medicus KW - Thiazoles -- pharmacology KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Bronchoalveolar Lavage Fluid -- analysis KW - Lung -- drug effects KW - Lung -- metabolism KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Glutathione -- metabolism KW - Lung Injury KW - Prostaglandin Endoperoxides -- metabolism KW - Cyclophosphamide -- toxicity KW - Prostaglandin Endoperoxides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79427577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Modulation+of+endoperoxide+product+levels+and+cyclophosphamide-induced+injury+by+glutathione+repletion.&rft.au=Cooper%2C+J+A%3BMerrill%2C+W+W&rft.aulast=Cooper&rft.aufirst=J&rft.date=1989-12-01&rft.volume=67&rft.issue=6&rft.spage=2316&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-12 N1 - Date created - 1990-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of excitatory amino acids and intraneuronal calcium in the acute intoxicational effects of ethanol. AN - 79413601; 2557974 JF - Clinical neuropharmacology AU - Deutsch, S I AU - Huntzinger, J A AU - Rosse, R B AU - Kaushik, M AU - Mastropaolo, J AD - Psychiatry Service, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 483 EP - 489 VL - 12 IS - 6 SN - 0362-5664, 0362-5664 KW - Amino Acids KW - 0 KW - Calcium Channels KW - Aspartic Acid KW - 30KYC7MIAI KW - N-Methylaspartate KW - 6384-92-5 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Calcium Channels -- physiology KW - Aspartic Acid -- analogs & derivatives KW - Synaptic Transmission -- drug effects KW - Humans KW - Aspartic Acid -- physiology KW - Synaptic Transmission -- physiology KW - Alcoholic Intoxication -- physiopathology KW - Neurons -- physiology KW - Calcium -- physiology KW - Amino Acids -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79413601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neuropharmacology&rft.atitle=The+role+of+excitatory+amino+acids+and+intraneuronal+calcium+in+the+acute+intoxicational+effects+of+ethanol.&rft.au=Deutsch%2C+S+I%3BHuntzinger%2C+J+A%3BRosse%2C+R+B%3BKaushik%2C+M%3BMastropaolo%2C+J&rft.aulast=Deutsch&rft.aufirst=S&rft.date=1989-12-01&rft.volume=12&rft.issue=6&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Clinical+neuropharmacology&rft.issn=03625664&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-15 N1 - Date created - 1990-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neutrophil degranulation inhibits potential hydroxyl-radical formation. Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniques. AN - 79410581; 2557840 AB - Hydroxyl radical (.OH) formation by neutrophils in vitro requires exogenous iron. Two recent studies [Britigan, Rosen, Thompson, Chai & Cohen (1986) J. Biol. Chem. 261, 17026-17032; Winterbourn (1987) J. Clin. Invest. 78, 545-550] both reported that neutrophil degranulation could potentially inhibit the formation of .OH, but differed in their conclusions as to the responsible factor, myeloperoxidase (MPO) or lactoferrin (LF). By using a previously developed spin-trapping system which allows specific on-line detection of superoxide anion (O2-) and .OH production, the impact of MPO and LF release on neutrophil .OH production was compared. When iron-diethylenetriaminepenta-acetic acid-supplemented neutrophils were stimulated with phorbol myristate acetate or opsonized zymosan, .OH formation occurred, but terminated prematurely in spite of continued O2- generation. Inhibition of MPO by azide increased the magnitude, but not the duration, of .OH formation. No azide effect was noted when MPO-deficient neutrophils were used. Anti-LF antibody increased both the magnitude and duration of .OH generation. Pretreatment of neutrophils with cytochalasin B to prevent phagosome formation did not alter the relative impact of azide or anti-LF on neutrophil .OH production. An effect of azide or anti-LF on spin-trapped-adduct stability was eliminated as a confounding factor. These data indicate that neutrophils possess two mechanisms for limiting .OH production. Implications for neutrophil-derived oxidant damage are discussed. JF - The Biochemical journal AU - Britigan, B E AU - Hassett, D J AU - Rosen, G M AU - Hamill, D R AU - Cohen, M S AD - Department of Medicine, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1989/12/01/ PY - 1989 DA - 1989 Dec 01 SP - 447 EP - 455 VL - 264 IS - 2 SN - 0264-6021, 0264-6021 KW - Antibodies KW - 0 KW - Azides KW - Free Radicals KW - Hydroxides KW - Lactoglobulins KW - Superoxides KW - 11062-77-4 KW - Hydroxyl Radical KW - 3352-57-6 KW - Zymosan KW - 9010-72-4 KW - Iron KW - E1UOL152H7 KW - Peroxidase KW - EC 1.11.1.7 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Lactoferrin KW - EC 3.4.21.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Superoxide Dismutase -- pharmacology KW - Oxygen Consumption KW - Zymosan -- pharmacology KW - Humans KW - Electron Spin Resonance Spectroscopy KW - In Vitro Techniques KW - Azides -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Superoxides -- blood KW - Neutrophils -- drug effects KW - Cell Degranulation KW - Iron -- pharmacology KW - Neutrophils -- enzymology KW - Lactoferrin -- blood KW - Neutrophils -- physiology KW - Lactoglobulins -- blood KW - Peroxidase -- blood KW - Hydroxides -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79410581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Neutrophil+degranulation+inhibits+potential+hydroxyl-radical+formation.+Relative+impact+of+myeloperoxidase+and+lactoferrin+release+on+hydroxyl-radical+production+by+iron-supplemented+neutrophils+assessed+by+spin-trapping+techniques.&rft.au=Britigan%2C+B+E%3BHassett%2C+D+J%3BRosen%2C+G+M%3BHamill%2C+D+R%3BCohen%2C+M+S&rft.aulast=Britigan&rft.aufirst=B&rft.date=1989-12-01&rft.volume=264&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-06 N1 - Date created - 1990-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1984 Nov 10;259(21):13391-4 [6092375] J Biol Chem. 1984 Dec 10;259(23):14354-6 [6094553] J Biol Chem. 1985 Mar 25;260(6):3275-80 [2982854] Annu Rev Med. 1985;36:263-74 [3888052] FEBS Lett. 1985 Nov 11;192(1):33-6 [2996939] Blood. 1986 Apr;67(4):865-72 [3006833] J Biol Chem. 1986 Apr 5;261(10):4426-31 [3007455] J Clin Invest. 1986 Aug;78(2):545-50 [3016031] Biochem J. 1986 Apr 15;235(2):521-9 [3741403] Acta Physiol Scand Suppl. 1986;548:9-37 [3019082] Biochem Pharmacol. 1986 Oct 15;35(20):3649-51 [3094544] J Biol Chem. 1986 Dec 25;261(36):17026-32 [3023380] Biochemistry. 1986 Dec 2;25(24):8042-8 [3026467] J Biol Chem. 1969 Nov 25;244(22):6049-55 [5389100] J Biol Chem. 1970 Sep 25;245(18):4641-6 [5466067] J Reticuloendothel Soc. 1972 Aug;12(2):170-96 [5075520] J Clin Invest. 1973 Mar;52(3):741-4 [4346473] Biochim Biophys Acta. 1973 Nov 2;329(1):156-8 [4206209] J Clin Invest. 1977 Aug;60(2):374-9 [874097] J Clin Invest. 1977 Dec;60(6):1266-79 [199619] J Exp Med. 1978 Feb 1;147(2):316-23 [203651] Biochem Biophys Res Commun. 1978 Mar 30;81(2):498-503 [666768] J Exp Med. 1978 Aug 1;148(2):490-506 [212502] Infect Immun. 1978 Dec;22(3):945-55 [730386] J Biol Chem. 1989 Jul 25;264(21):12299-302 [2545706] Free Radic Biol Med. 1988;5(2):81-8 [2855421] FEBS Lett. 1979 Apr 1;100(1):23-6 [220087] J Clin Invest. 1979 Dec;64(6):1642-51 [500830] J Clin Invest. 1979 Dec;64(6):1725-9 [227939] Biochim Biophys Acta. 1980 Feb 21;628(1):90-7 [6892610] Arch Biochem Biophys. 1980 Mar;200(1):1-16 [6244786] Blood. 1980 Jun;55(6):1003-10 [7378576] Inflammation. 1980 Mar;4(1):65-71 [6248463] Biochemistry. 1980 Aug 19;19(17):4072-9 [6250582] J Clin Invest. 1981 Feb;67(2):352-60 [6780607] J Biol Chem. 1981 Jul 25;256(14):7094-6 [6265438] Ann Intern Med. 1981 Sep;95(3):293-301 [6267975] Rev Infect Dis. 1981 May-Jun;3(3):565-98 [7025152] Biochem J. 1981 Oct 1;199(1):259-61 [7337708] Biochim Biophys Acta. 1982 Mar 15;715(1):116-20 [6280774] Biochemistry. 1982 Aug 17;21(17):4110-6 [6289871] Blood. 1983 Mar;61(3):483-92 [6297637] Am J Clin Pathol. 1983 Jun;79(6):673-7 [6303107] Biochem J. 1983 Jan 15;210(1):15-9 [6303309] J Cell Biol. 1983 Jul;97(1):52-61 [6408102] Infect Immun. 1984 Jan;43(1):435-7 [6317572] J Clin Invest. 1984 Jun;73(6):1576-9 [6327764] J Infect Dis. 1984 Jul;150(1):49-56 [6431014] J Reticuloendothel Soc. 1978 Sep;24(3):295-310 [83363] Blood. 1979 Apr;53(4):666-76 [426913] J Biol Chem. 1987 Jan 25;262(3):1098-104 [3027077] J Immunol. 1987 Apr 1;138(7):2177-83 [3031158] Biochem J. 1987 Jan 1;241(1):273-8 [3032157] J Leukoc Biol. 1987 Apr;41(4):349-62 [3033110] Lab Invest. 1987 Jul;57(1):37-44 [3037192] Free Radic Biol Med. 1987;3(1):33-9 [3040537] Biochim Biophys Acta. 1988 May 13;969(3):236-41 [2835986] Biochim Biophys Acta. 1988 Aug 31;956(1):58-62 [2841980] Biochem J. 1988 Jun 1;252(2):529-36 [2843172] J Biol Chem. 1988 Sep 25;263(27):13797-801 [2843536] Anal Biochem. 1988 Aug 1;172(2):360-7 [2847582] J Exp Med. 1988 Dec 1;168(6):2367-72 [3199073] Biochem J. 1989 Mar 1;258(2):617-20 [2706005] Free Radic Biol Med. 1989;6(4):385-92 [2540071] Free Radic Res Commun. 1987;4(2):115-23 [2854101] Biochim Biophys Acta. 1989 Jun 27;991(3):459-64 [2543462] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of guanine nucleotide regulatory proteins in insulin stimulation of glucose transport in rat adipocytes. Influence of bacterial toxins. AN - 79410411; 2557836 AB - The potential role of guanine nucleotide regulatory proteins (G-proteins) in acute insulin regulation of glucose transport was investigated by using bacterial toxins which are known to modify these proteins. Cholera-toxin treatment of isolated rat adipocytes had no effect on either 2-deoxyglucose transport or insulin binding. Pertussis-toxin treatment resulted in an inhibition of both insulin binding and glucose transport. Insulin binding was decreased in pertussis-toxin-treated cells by up to 40%, owing to a lowering of the affinity of the receptor for hormone, with no change in hormone internalization. The dose-response curve for insulin stimulation of glucose transport was strongly shifted to the right by pertussis-toxin treatment [EC50 (half-maximally effective insulin concn.) = 0.31 +/- 0.04 ng/ml in control cells; 2.29 +/- 1.0 in treated cells), whereas cholera toxin had only a small effect (EC50 = 0.47 +/- 0.02 ng/ml). Correcting for the change in hormone binding, pertussis toxin was found to decrease the coupling efficiency of occupied receptors (50% of maximal insulin effect with 928 molecules bound/cell in control and 3418 in treated cells). Pertussis-toxin inhibition of insulin sensitivity was slow in onset, requiring 2-3 h for completion. Under conditions where pertussis-toxin inhibition of insulin sensitivity was maximal, a 41,000 Da protein similar to the alpha subunit of Gi (the inhibitory G-protein) was found to be fully ribosylated. These results are consistent with the concept that pertussis-toxin-sensitive G-protein(s) can modify the insulin-receptor/glucose-transport coupling system. JF - The Biochemical journal AU - Ciaraldi, T P AU - Maisel, A AD - Veterans Administration Medical Center, Medical Research Service, San Diego, CA 92161. Y1 - 1989/12/01/ PY - 1989 DA - 1989 Dec 01 SP - 389 EP - 396 VL - 264 IS - 2 SN - 0264-6021, 0264-6021 KW - Deoxy Sugars KW - 0 KW - Insulin KW - Virulence Factors, Bordetella KW - NAD KW - 0U46U6E8UK KW - Cholera Toxin KW - 9012-63-9 KW - Deoxyglucose KW - 9G2MP84A8W KW - Cyclic AMP KW - E0399OZS9N KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Receptor, Insulin KW - EC 2.7.10.1 KW - Adenosine Deaminase KW - EC 3.5.4.4 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Animals KW - Cell Membrane -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Adenosine Deaminase -- pharmacology KW - Biological Transport, Active -- drug effects KW - NAD -- metabolism KW - Cells, Cultured KW - Kinetics KW - Signal Transduction -- drug effects KW - Binding, Competitive KW - Cyclic AMP -- metabolism KW - Cell Membrane -- metabolism KW - Male KW - Virulence Factors, Bordetella -- pharmacology KW - Adipose Tissue -- metabolism KW - Receptor, Insulin -- drug effects KW - Cholera Toxin -- pharmacology KW - Adipose Tissue -- drug effects KW - Insulin -- metabolism KW - Insulin -- pharmacology KW - GTP-Binding Proteins -- physiology KW - Receptor, Insulin -- metabolism KW - Deoxyglucose -- metabolism KW - Deoxy Sugars -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79410411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Role+of+guanine+nucleotide+regulatory+proteins+in+insulin+stimulation+of+glucose+transport+in+rat+adipocytes.+Influence+of+bacterial+toxins.&rft.au=Ciaraldi%2C+T+P%3BMaisel%2C+A&rft.aulast=Ciaraldi&rft.aufirst=T&rft.date=1989-12-01&rft.volume=264&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-06 N1 - Date created - 1990-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Life Sci. 1986 Jul 21;39(3):187-94 [3016436] Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:173-82 [6145319] J Biol Chem. 1987 Jan 5;262(1):245-53 [3025204] Proc Natl Acad Sci U S A. 1987 Jan;84(1):41-5 [3540958] J Biol Chem. 1987 Jan 15;262(2):841-7 [3805010] J Biol Chem. 1987 Feb 5;262(4):1842-7 [3100537] FEBS Lett. 1987 Feb 23;212(2):281-8 [3028864] Biochem J. 1986 Nov 15;240(1):35-40 [3103610] Mol Cell Endocrinol. 1987 Jan;49(1):1-16 [2435586] Endocrinology. 1987 Jun;120(6):2339-45 [3552635] Nature. 1987 May 21-27;327(6119):229-32 [3106832] Annu Rev Biochem. 1987;56:615-49 [3113327] Biochem J. 1987 May 1;243(3):789-95 [2821992] J Biol Chem. 1987 Nov 15;262(32):15702-7 [3680221] Biochem J. 1987 Oct 1;247(1):223-7 [3120702] Biochem Biophys Res Commun. 1988 Mar 30;151(3):1262-8 [2451519] FEBS Lett. 1984 Oct 29;176(2):301-6 [6386524] Biochem Pharmacol. 1985 Mar 1;34(5):649-53 [2983732] Annu Rev Med. 1985;36:429-51 [2986528] J Clin Invest. 1985 Oct;76(4):1559-65 [2997284] J Biol Chem. 1985 Dec 15;260(29):15946-52 [4066699] Can J Physiol Pharmacol. 1985 Aug;63(8):1017-22 [3907810] Endocrinology. 1986 Jul;119(1):50-7 [3013597] FEBS Lett. 1986 Jul 7;202(2):260-6 [3013688] J Biol Chem. 1986 Aug 5;261(22):10033-6 [3525539] Am J Physiol. 1988 Jul;255(1 Pt 1):C51-9 [2839035] J Cell Physiol. 1988 Jul;136(1):1-12 [2840437] J Biol Chem. 1988 Sep 5;263(25):12333-41 [3137226] J Biol Chem. 1988 Oct 25;263(30):15546-52 [3139671] Biochem J. 1988 Oct 1;255(1):1-13 [2848502] Ann Intern Med. 1989 Feb 1;110(3):195-201 [2536258] Mol Cell Endocrinol. 1988 Nov;60(1):31-41 [2850947] Biochem J. 1988 Dec 1;256(2):515-20 [3066348] J Biol Chem. 1964 Feb;239:375-80 [14169133] J Lipid Res. 1968 Jan;9(1):110-9 [4295346] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12 [4318781] Anal Biochem. 1974 Apr;58(2):541-8 [4827395] Anal Biochem. 1976 May 7;72:248-54 [942051] Biochem J. 1978 Apr 15;172(1):137-45 [656068] Diabetes. 1979 Feb;28(2):87-95 [154427] J Biol Chem. 1980 Feb 25;255(4):1239-41 [6243633] J Biol Chem. 1982 Jun 25;257(12):7210-6 [7200979] J Biol Chem. 1982 Aug 10;257(15):8867-71 [7096339] FEBS Lett. 1983 Feb 21;152(2):261-4 [6130979] J Biol Chem. 1983 Jun 10;258(11):6756-61 [6343381] J Biol Chem. 1983 Jun 25;258(12):7386-94 [6134722] FEBS Lett. 1983 Sep 5;161(1):149-52 [6350045] J Biol Chem. 1983 Sep 25;258(18):10938-43 [6350297] Biochem J. 1983 Aug 15;214(2):547-52 [6311187] Proc Natl Acad Sci U S A. 1983 Nov;80(21):6547-51 [6195660] Biochem Biophys Res Commun. 1983 Oct 31;116(2):593-8 [6316958] J Biol Chem. 1984 Jan 25;259(2):1086-90 [6319376] J Biol Chem. 1986 Sep 5;261(25):11558-62 [3091591] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol myristate acetate inhibits acidification by turtle urinary bladder. AN - 79406959; 2481401 AB - The effects of phorbol myristate acetate (PMA) on acid secretion by the turtle urinary bladder were examined to evaluate the importance of protein phosphorylation in modulating the distal acidification system. In HCO3-free PO4 buffer 0.2 mM mucosal PMA inhibited reverse short-circuit current (RSCC) by 42%. The inhibition of RSCC was dose dependent, and RSCC approached zero at high concentrations of PMA. PMA also inhibited acid secretion measured titrimetrically but had no effect on RSCC from bladders in which proton secretion was selectively inhibited by an adverse pH gradient or serosal 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. The inhibition by PMA was duplicated by 1-oleoyl-2-acetyl-rac-glycerol, but not by an inactive phorbol ester. The PMA inhibition was much more potent with mucosal compared with serosal application. The PMA inhibition caused a significant 0.15 pH unit reduction of carbonic anhydrase (CA) cell cytoplasmic pH and a change in the CA cell morphology. Unlike the inhibition of proton transport induced by acetazolamide, the PMA inhibition was neither reversed nor prevented by sodium azide. We conclude that PMA decreases basal acid secretion and blocks the stimulatory effects of CO2 by an azide-insensitive mechanism distinct from that of acetazolamide. In view of recent findings that PMA stimulates HCO3 secretion by the turtle bladder, these results suggest that kinase C-mediated protein phosphorylation may be a central event in the transition from the secretion of acid to the secretion of base. JF - The American journal of physiology AU - Graber, M AU - Devine, P AU - Dixon, T AD - Northport Veterans Administration Medical Center 11768. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - F1124 EP - F1131 VL - 257 IS - 6 Pt 2 SN - 0002-9513, 0002-9513 KW - Azides KW - 0 KW - Bicarbonates KW - Carbon Dioxide KW - 142M471B3J KW - Bucladesine KW - 63X7MBT2LQ KW - Sodium Azide KW - 968JJ8C9DV KW - Cyclic AMP KW - E0399OZS9N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Acetazolamide KW - O3FX965V0I KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Index Medicus KW - Animals KW - Hydrogen-Ion Concentration KW - Acetazolamide -- pharmacology KW - Turtles KW - Cyclic AMP -- physiology KW - Bucladesine -- pharmacology KW - Kinetics KW - Bicarbonates -- pharmacology KW - In Vitro Techniques KW - Azides -- pharmacology KW - Membrane Potentials -- drug effects KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Carbon Dioxide -- pharmacology KW - Urinary Bladder -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Urinary Bladder -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79406959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Phorbol+myristate+acetate+inhibits+acidification+by+turtle+urinary+bladder.&rft.au=Graber%2C+M%3BDevine%2C+P%3BDixon%2C+T&rft.aulast=Graber&rft.aufirst=M&rft.date=1989-12-01&rft.volume=257&rft.issue=6+Pt+2&rft.spage=F1124&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-02 N1 - Date created - 1990-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Site and mechanism of enhanced gastrointestinal absorption of aluminum by citrate. AN - 79399219; 2601265 AB - Clinical and experimental studies have shown that citrate markedly enhances the intestinal absorption of aluminum (Al), but the site and mechanism of enhanced absorption are unknown. To determine where in the gastrointestinal tract aluminum citrate (Alcitr) was absorbed. Alcitr was gavaged with D-[1-3H] glucose in male Sprague-Dawley rats. Plasma Al levels increased rapidly and simultaneously peaked with D-[1-3G] glucose, suggesting early proximal bowel absorption. In in vitro duodenal and jejunal everted gut preparations, Alcitr incubation resulted in increased tissue Al levels and markedly enhanced transmural transport of Al and citr. Unlike citr, the transmural movement of Al was independent of temperature (37 degrees C vs. 4 degrees C). On the other hand, Al lactate (al Lac) increased tissue associated Al levels but had no effect on transmural Al movement. To determine if this large flux of Al following Alcitr administration was due to paracellular movement, ruthenium red and Ussing chamber studies were used to evaluate the morphologic and functional integrity of cellular tight junctions. Alcitr, as opposed to AlCl3, markedly increased ruthenium red deposits in intercellular spaces, especially around goblet cells, and induced a prolonged significant reduction in transmural resistance. Alcitr also resulted in rapid and nearly complete (99.7%) chelation of free calcium, an event known to disrupt cellular tight junction integrity. Taken together, these data suggest that enhanced Al absorption following administration of Alcitr occurs in the proximal bowel via the paracellular pathway due to the opening of cellular tight junctions. JF - Kidney international AU - Froment, D P AU - Molitoris, B A AU - Buddington, B AU - Miller, N AU - Alfrey, A C AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 978 EP - 984 VL - 36 IS - 6 SN - 0085-2538, 0085-2538 KW - Citrates KW - 0 KW - Citric Acid KW - 2968PHW8QP KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Duodenum -- physiology KW - Jejunum -- physiology KW - Intercellular Junctions -- physiology KW - Drug Synergism KW - Male KW - Citrates -- pharmacology KW - Aluminum -- pharmacokinetics KW - Intestinal Absorption -- drug effects KW - Citrates -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79399219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Site+and+mechanism+of+enhanced+gastrointestinal+absorption+of+aluminum+by+citrate.&rft.au=Froment%2C+D+P%3BMolitoris%2C+B+A%3BBuddington%2C+B%3BMiller%2C+N%3BAlfrey%2C+A+C&rft.aulast=Froment&rft.aufirst=D&rft.date=1989-12-01&rft.volume=36&rft.issue=6&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-02 N1 - Date created - 1990-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute radiodermatitis from occupational exposure to iridium 192. AN - 79378303; 2688134 AB - Industrial radiography using the man-made radioisotope iridium 129 is commonplace in the southern states. Despite established procedures and safeguards, accidental exposure may result in typical acute radiodermatitis. We have presented a clinical example of this phenomenon. JF - Southern medical journal AU - Becker, J AU - Rosen, T AD - Veterans Administration Medical Center, Houston, Tex. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1561 EP - 1563 VL - 82 IS - 12 SN - 0038-4348, 0038-4348 KW - Iridium Radioisotopes KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Humans KW - Middle Aged KW - Male KW - Radiodermatitis -- etiology KW - Occupational Diseases -- etiology KW - Ankle KW - Iridium Radioisotopes -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79378303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Acute+radiodermatitis+from+occupational+exposure+to+iridium+192.&rft.au=Becker%2C+J%3BRosen%2C+T&rft.aulast=Becker&rft.aufirst=J&rft.date=1989-12-01&rft.volume=82&rft.issue=12&rft.spage=1561&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-23 N1 - Date created - 1990-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Critique of the clinical importance of diurectic-induced hypokalemia and elevated cholesterol level. AN - 79374247; 2688584 JF - Archives of internal medicine AU - Freis, E D AD - Veterans Administration Medical Center, Washington, DC 20815. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 2640 EP - 2648 VL - 149 IS - 12 SN - 0003-9926, 0003-9926 KW - Diuretics KW - 0 KW - Cholesterol KW - 97C5T2UQ7J KW - Magnesium KW - I38ZP9992A KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Myocardial Infarction -- blood KW - Hypokalemia -- chemically induced KW - Arrhythmias, Cardiac -- etiology KW - Magnesium -- blood KW - Death, Sudden -- etiology KW - Myocardial Infarction -- complications KW - Humans KW - Electrocardiography KW - Potassium -- blood KW - Clinical Trials as Topic KW - Monitoring, Physiologic KW - Diuretics -- adverse effects KW - Cholesterol -- blood KW - Coronary Disease -- blood KW - Coronary Disease -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79374247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Critique+of+the+clinical+importance+of+diurectic-induced+hypokalemia+and+elevated+cholesterol+level.&rft.au=Freis%2C+E+D&rft.aulast=Freis&rft.aufirst=E&rft.date=1989-12-01&rft.volume=149&rft.issue=12&rft.spage=2640&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-12 N1 - Date created - 1990-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1991 Feb;151(2):398-402 [2036107] Arch Intern Med. 1990 Dec;150(12):2600, 2603 [2134164] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Smoking control in a psychiatric setting. AN - 79365429; 2591889 JF - Hospital & community psychiatry AU - Dawley, H H AU - Williams, J L AU - Guidry, L S AU - Dawley, L T AD - Psychology Service, Veterans Administration Medical Center, New Orleans, Louisiana 70146. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1299 EP - 1301 VL - 40 IS - 12 SN - 0022-1597, 0022-1597 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Attitude of Health Personnel KW - Hospital Bed Capacity, 300 to 499 KW - Patient Compliance KW - Humans KW - Louisiana KW - Hospitals, Veterans KW - Alcoholism -- rehabilitation KW - Psychiatric Department, Hospital -- organization & administration KW - Tobacco Smoke Pollution -- prevention & control KW - Smoking -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79365429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hospital+%26+community+psychiatry&rft.atitle=Smoking+control+in+a+psychiatric+setting.&rft.au=Dawley%2C+H+H%3BWilliams%2C+J+L%3BGuidry%2C+L+S%3BDawley%2C+L+T&rft.aulast=Dawley&rft.aufirst=H&rft.date=1989-12-01&rft.volume=40&rft.issue=12&rft.spage=1299&rft.isbn=&rft.btitle=&rft.title=Hospital+%26+community+psychiatry&rft.issn=00221597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-17 N1 - Date created - 1990-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recognizing the psychiatric water intoxicator. AN - 79355087; 2589423 JF - The American journal of nursing AU - Stanley-Tilt, C A AD - Veterans Administration Medical Center, Salem, VA. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 1636 EP - 1637 VL - 89 IS - 12 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Humans KW - Compulsive Behavior KW - Water Intoxication -- diagnosis KW - Water Intoxication -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79355087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Recognizing+the+psychiatric+water+intoxicator.&rft.au=Stanley-Tilt%2C+C+A&rft.aulast=Stanley-Tilt&rft.aufirst=C&rft.date=1989-12-01&rft.volume=89&rft.issue=12&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-05 N1 - Date created - 1990-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 5-Fluorouracil infusion and mitomycin combination chemotherapy in the management of patients with advanced non-small-cell lung cancer. AN - 79353537; 2556013 AB - We have carried out a phase II study evaluating the activity of a 5-fluorouracil drug combination in patients with advanced non-small-cell lung cancer. Patients were given 60 mg/m2 of methotrexate i.v. on day 1. On day 2, 750 mg/m2 of 5-fluorouracil was administered as a 24-h infusion daily for 3 days. Also on day 3, 10 mg/m2 of mitomycin was given i.v. along with folinic acid. Folinic acid was started on day 3 initially at a dose of 25 mg/m2 intravenously every 6 h for three doses, followed by a 2-h infusion of 200 mg/m2 daily on days 3 and 4. Therapy was repeated every 28 days. Fourteen of 35 patients (40%) experienced a partial response to chemotherapy. The median survival of the entire group was 19 weeks. Mucositis was a common side effect but severe leukopenia, anemia, renal insufficiency, and skin ulceration were rare. This study demonstrated that 5-fluorouracil infusion therapy has activity in advanced non-small-cell lung cancer but the responses are not durable. Further studies evaluating differing dose schedules and alternate 5-fluorouracil infusion-based drug combinations seems warranted. JF - American journal of clinical oncology AU - Weir, A B AU - Niell, H B AU - Griffin, J P AD - Hematology-Oncology Section, Veterans Administration Medical Center, Memphis, Tennessee. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 521 EP - 523 VL - 12 IS - 6 SN - 0277-3732, 0277-3732 KW - Mitomycins KW - 0 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Drug Evaluation KW - Neoplasm Staging KW - Leucovorin -- administration & dosage KW - Humans KW - Adult KW - Mitomycins -- administration & dosage KW - Aged KW - Middle Aged KW - Methotrexate -- administration & dosage KW - Male KW - Female KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79353537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=5-Fluorouracil+infusion+and+mitomycin+combination+chemotherapy+in+the+management+of+patients+with+advanced+non-small-cell+lung+cancer.&rft.au=Weir%2C+A+B%3BNiell%2C+H+B%3BGriffin%2C+J+P&rft.aulast=Weir&rft.aufirst=A&rft.date=1989-12-01&rft.volume=12&rft.issue=6&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-10 N1 - Date created - 1990-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Myocardial ischemia during cocaine withdrawal. AN - 79328229; 2817640 AB - To determine the prevalence of myocardial ischemia in patients with cocaine addiction. Myocardial ischemia in chronic cocaine users was detected by serial 24-hour electrocardiographic ambulatory (Holter) monitoring and exercise treadmill testing in chronic cocaine users. The Holter tapes were coded, scanned in a blinded manner, and mixed with the tapes of 42 normal volunteers and 119 patients with either stable or unstable angina. A 28-day inpatient, substance abuse treatment program followed by an outpatient treatment program. Twenty-one consecutive male chronic cocaine users. Eight of the 21 patients with cocaine addiction had frequent episodes of ST elevation during Holter monitoring; these episodes occurred almost exclusively during the first 2 weeks of withdrawal. None of the volunteers and patients with stable angina and only 4% of the patients with unstable angina had episodes of ST elevation during Holter monitoring (cocaine users compared with volunteers, P = 0.0004). Of the 20 cocaine patients who had exercise treadmill testing, only 1 had a positive test for ischemia. Cocaine users frequently develop silent myocardial ischemia manifesting as episodes of ST elevation during the first weeks of withdrawal. The underlying mechanisms for these changes remain unknown, but our observations support the hypothesis that coronary vasospasm plays an important role in cocaine-related ischemic syndromes. JF - Annals of internal medicine AU - Nademanee, K AU - Gorelick, D A AU - Josephson, M A AU - Ryan, M A AU - Wilkins, J N AU - Robertson, H A AU - Mody, F V AU - Intarachot, V AD - West Los Angeles Veterans Administration Medical Center, California. Y1 - 1989/12/01/ PY - 1989 DA - 1989 Dec 01 SP - 876 EP - 880 VL - 111 IS - 11 SN - 0003-4819, 0003-4819 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test KW - Electrocardiography, Ambulatory KW - Dopamine -- deficiency KW - Humans KW - Electrocardiography KW - Coronary Vasospasm -- chemically induced KW - Adult KW - Prognosis KW - Statistics as Topic KW - Male KW - Substance Withdrawal Syndrome KW - Coronary Disease -- chemically induced KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79328229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Myocardial+ischemia+during+cocaine+withdrawal.&rft.au=Nademanee%2C+K%3BGorelick%2C+D+A%3BJosephson%2C+M+A%3BRyan%2C+M+A%3BWilkins%2C+J+N%3BRobertson%2C+H+A%3BMody%2C+F+V%3BIntarachot%2C+V&rft.aulast=Nademanee&rft.aufirst=K&rft.date=1989-12-01&rft.volume=111&rft.issue=11&rft.spage=876&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-20 N1 - Date created - 1989-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 1990 Apr 1;112(7):548-9 [2360936] Ann Intern Med. 1990 May 1;112(9):712 [2334085] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Primary lung cancer: biodistribution and dosimetry of two In-111-labeled monoclonal antibodies. AN - 79304067; 2510212 AB - This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCEO25 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic whole-body retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar. JF - Radiology AU - Brown, P H AU - Krishnamurthy, G T AU - Turner, F E AU - Denney, R K AU - Gilbert, S A AU - Slauson, M E AD - Nuclear Medicine Service, Veterans Administration Medical Center, Portland, OR 97207. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 701 EP - 705 VL - 173 IS - 3 SN - 0033-8419, 0033-8419 KW - Antibodies, Monoclonal KW - 0 KW - Carcinoembryonic Antigen KW - Indium Radioisotopes KW - Abridged Index Medicus KW - Index Medicus KW - Radiation Dosage KW - Lung -- diagnostic imaging KW - Carcinoembryonic Antigen -- immunology KW - Humans KW - Adenocarcinoma -- immunology KW - Whole-Body Counting KW - Liver -- diagnostic imaging KW - Radionuclide Imaging KW - Antibodies, Monoclonal -- pharmacokinetics KW - Indium Radioisotopes -- pharmacokinetics KW - Lung Neoplasms -- diagnostic imaging KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79304067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Primary+lung+cancer%3A+biodistribution+and+dosimetry+of+two+In-111-labeled+monoclonal+antibodies.&rft.au=Brown%2C+P+H%3BKrishnamurthy%2C+G+T%3BTurner%2C+F+E%3BDenney%2C+R+K%3BGilbert%2C+S+A%3BSlauson%2C+M+E&rft.aulast=Brown&rft.aufirst=P&rft.date=1989-12-01&rft.volume=173&rft.issue=3&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of corticosteroid treatment on cell recovery by lung lavage in acute radiation-induced lung injury. AN - 79451899; 2616742 AB - The purpose of this study was to quantitate cell populations recovered by lung lavage up to 6 weeks following thoracic irradiation (24 Gy) as an index of the acute inflammatory response within lung structures. Additionally, rats were treated five times weekly with intraperitoneal saline (0.3 cc) or methylprednisolone (7.5 mg/kg/week). Lung lavage of irradiated rats recovered increased numbers of total cells compared to controls beginning 3 weeks after irradiation (P less than 0.05). The initial increase in number of cells recovered was attributable to an influx of neutrophils (P less than 0.05), and further increases at 4 and 6 weeks were associated with increased numbers of recovered macrophages (P less than 0.05). Lung lavage of steroid-treated rats at 6 weeks after irradiation recovered increased numbers of all cell populations compared to controls (P less than 0.05); however, numbers of recovered total cells, macrophages, neutrophils, and lymphocytes were all significantly decreased compared to saline-treated rats (P less than 0.05). The number of inflammatory cells recovered by lung lavage during acute radiation-induced lung injury is significantly diminished by corticosteroid treatment. Changes in cells recovered by lung lavage can also be correlated with alteration in body weight and respiration rate subsequent to treatment with thoracic irradiation and/or corticosteroids. JF - Radiation research AU - Wesselius, L J AU - Floreani, A A AU - Kimler, B F AU - Papasian, C J AU - Dixon, A Y AD - Department of Medicine, Kansas City Veterans Administration Medical Center, Missouri 64128. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 313 EP - 322 VL - 120 IS - 2 SN - 0033-7587, 0033-7587 KW - Methylprednisolone KW - X4W7ZR7023 KW - Index Medicus KW - Space life sciences KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Female KW - Radiation Injuries, Experimental -- pathology KW - Methylprednisolone -- therapeutic use KW - Lung -- drug effects KW - Lung -- pathology KW - Radiation Injuries, Experimental -- drug therapy KW - Bronchoalveolar Lavage Fluid -- pathology KW - Lung -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79451899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Effect+of+corticosteroid+treatment+on+cell+recovery+by+lung+lavage+in+acute+radiation-induced+lung+injury.&rft.au=Wesselius%2C+L+J%3BFloreani%2C+A+A%3BKimler%2C+B+F%3BPapasian%2C+C+J%3BDixon%2C+A+Y&rft.aulast=Wesselius&rft.aufirst=L&rft.date=1989-11-01&rft.volume=120&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-27 N1 - Date created - 1990-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased proteoglycan synthesis following the differentiation of F9 embryonal carcinoma cells: formation of a differentiation-specific proteoheparan sulfate. AN - 79449918; 2615695 AB - We have examined changes in proteoglycan synthesis by F9 embryonal carcinoma cells after the cells have been treated with retinoic acid or retinoic acid plus cholera toxin. Retinoic acid is known to stimulate the differentiation of this cell type to a primitive endoderm-like cell characterized by the production of basement membrane components such as type IV collagen, laminin and proteoglycans. We have now demonstrated that proteoglycan synthesis and secretion were further stimulated when cholera toxin was added in addition to retinoic acid. Moreover, media of these fully differentiated cells was found to contain a different species of proteoheparan sulfate not produced by stem cells or retinoic acid-treated cells. This proteoheparan sulfate had a high density upon CsCl gradient centrifugation. The protein core of this proteoheparan sulfate was estimated by SDS gel electrophoresis to be approximately 15,000 daltons. JF - Matrix (Stuttgart, Germany) AU - Baldwin, C T AU - Silbert, J E AU - Humphries, D E AU - Cogburn, J N AU - Smith, B D AD - Collagen and Connective Tissue Laboratories, Veterans Administration Outpatient Clinic, Boston, MA 02108. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 389 EP - 396 VL - 9 IS - 5 SN - 0934-8832, 0934-8832 KW - Glycosaminoglycans KW - 0 KW - Proteoglycans KW - heparin proteoglycan KW - Tretinoin KW - 5688UTC01R KW - Heparin KW - 9005-49-6 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Centrifugation, Density Gradient KW - Tretinoin -- pharmacology KW - Animals KW - Tumor Cells, Cultured KW - Glycosaminoglycans -- biosynthesis KW - Cholera Toxin -- pharmacology KW - Cell Differentiation KW - Glycosaminoglycans -- pharmacokinetics KW - Embryonal Carcinoma Stem Cells KW - Proteoglycans -- biosynthesis KW - Neoplastic Stem Cells -- physiology KW - Proteoglycans -- metabolism KW - Heparin -- analogs & derivatives KW - Heparin -- metabolism KW - Neoplastic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79449918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Matrix+%28Stuttgart%2C+Germany%29&rft.atitle=Increased+proteoglycan+synthesis+following+the+differentiation+of+F9+embryonal+carcinoma+cells%3A+formation+of+a+differentiation-specific+proteoheparan+sulfate.&rft.au=Baldwin%2C+C+T%3BSilbert%2C+J+E%3BHumphries%2C+D+E%3BCogburn%2C+J+N%3BSmith%2C+B+D&rft.aulast=Baldwin&rft.aufirst=C&rft.date=1989-11-01&rft.volume=9&rft.issue=5&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Matrix+%28Stuttgart%2C+Germany%29&rft.issn=09348832&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of converting enzyme inhibition on the course of adriamycin-induced nephropathy. AN - 79445156; 2559236 AB - The effect of the converting enzyme inhibitor (CEI) enalapril was assessed in Munich-Wistar rats with established adriamycin nephrosis. Rats were given a single dose of adriamycin and one month later divided into four groups matched for albuminuria, blood pressure, and plasma albumin concentration. Groups 1 and 3 remained untreated while groups 2 and 4 received enalapril. Groups 1 and 2 underwent micropuncture studies after 10 days. These short-term studies showed that enalapril reduced arterial blood pressure (101 +/- 2 vs. 124 +/- 3 mm Hg, group 2 vs. 1, P less than 0.05) and glomerular capillary pressure (54 +/- 1 vs. 61 +/- 2 mm Hg, P less than 0.05) without reducing albuminuria (617 +/- 50 vs. 570 +/- 47 mg/day) or GFR (1.03 +/- 0.04 vs. 1.04 +/- 0.11 ml/min). Groups 3 and 4 were studied at four and at six months to assess the effect of enalapril on progression of renal injury in adriamycin nephrosis. Chronic enalapril treatment reduced blood pressure without reducing albuminuria in group 4. Untreated group 3 rats exhibited a progressive reduction in GFR (0.35 +/- 0.08 ml/min at 4 months, 0.27 +/- 0.07 ml/min at 6 months). Enalapril treatment blunted but did not prevent reduction in GFR in group 4 (0.86 +/- 0.15 ml/min at 4 months, 0.69 +/- 0.13 ml/min at 6 months, both P less than 0.05 vs. group 3). Reduction in GFR was associated with the development of glomerular sclerosis in both treated and untreated rats.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Kidney international AU - Scholey, J W AU - Miller, P L AU - Rennke, H G AU - Meyer, T W AD - Department of Medicine, Palo Alto Veterans Administration Medical Center, California. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 816 EP - 822 VL - 36 IS - 5 SN - 0085-2538, 0085-2538 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Enalapril KW - 69PN84IO1A KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Animals KW - Time Factors KW - Male KW - Nephrotic Syndrome -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Enalapril -- therapeutic use KW - Nephrotic Syndrome -- chemically induced KW - Doxorubicin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79445156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Effect+of+converting+enzyme+inhibition+on+the+course+of+adriamycin-induced+nephropathy.&rft.au=Scholey%2C+J+W%3BMiller%2C+P+L%3BRennke%2C+H+G%3BMeyer%2C+T+W&rft.aulast=Scholey&rft.aufirst=J&rft.date=1989-11-01&rft.volume=36&rft.issue=5&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of iron in the tubulo-interstitial injury in nephrotoxic serum nephritis. AN - 79443867; 2615188 AB - We studied the possibility that tubule fluid iron could be involved in the pathogenesis of the tubulo-interstitial injury associated with primary glomerular disease. Tubule fluid iron is determined by the magnitude of the glomerular leak for transferrin and the iron saturation of transferrin. To minimize tubule fluid iron in an experimental model of glomerulonephritis, iron deficiency was induced in rats prior to the induction of nephrotoxic serum nephritis. Iron deficiency did not effect the development of glomerular disease as determined by proteinuria, but had a marked effect on preventing the development of tubulo-interstitial disease and renal functional deterioration. There was also a strong correlation between the amount of functional deterioration and extent of tubulo-interstitial disease and urinary iron excretion in both the control and iron deficient animals. It is proposed that injury results from iron being dissociated from transferrin at the more acid pH of the tubule fluid. Iron, a transition element, is able to catalyze the Haber-Weiss reaction with the formation of free hydroxyl radicals which causes renal tubule cell injury. This tubulo-interstitial injury is the major determinate of progressive renal functional deterioration in this experimental model of glomerulonephritis. JF - Kidney international AU - Alfrey, A C AU - Froment, D H AU - Hammond, W S AD - Department of Medicine and Pathology, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 753 EP - 759 VL - 36 IS - 5 SN - 0085-2538, 0085-2538 KW - Free Radicals KW - 0 KW - Transferrin KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Transferrin -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Kidney Tubules -- pathology KW - Proteinuria -- complications KW - Microscopy, Electron KW - Kidney Tubules -- metabolism KW - Male KW - Iron -- adverse effects KW - Iron -- deficiency KW - Nephritis, Interstitial -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79443867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Role+of+iron+in+the+tubulo-interstitial+injury+in+nephrotoxic+serum+nephritis.&rft.au=Alfrey%2C+A+C%3BFroment%2C+D+H%3BHammond%2C+W+S&rft.aulast=Alfrey&rft.aufirst=A&rft.date=1989-11-01&rft.volume=36&rft.issue=5&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. AN - 79441000; 2613750 AB - We have investigated the actions of transforming growth factor (TGF) type alpha on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGF alpha results in elevated levels of EGF receptor mRNA. This increase in mRNA accumulation showed time and dose dependence. Addition of TGF beta 1 enhanced the accumulation of EGF receptor mRNA induced by TGF alpha in a time- and dose-dependent manner. We also found that triiodothyronine at physiological concentrations exerts synergistic control on the action of TGF alpha alone, or in association with TGF beta 1, on EGF receptor mRNA expression. Similarly, retinoic acid treatment also enhanced in a time- and dose-dependent manner the TGF alpha-dependent response of EGF receptor mRNA and acted synergistically with TGF beta 1. The results described here suggest that optimum regulation of EGF receptor gene expression by TGF alpha is a complex process involving synergistic interactions with heterologous growth factors and hormones. JF - Journal of cellular biochemistry AU - Fernandez-Pol, J A AU - Klos, D J AU - Hamilton, P D AD - Laboratory of Molecular Oncology, Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 159 EP - 170 VL - 41 IS - 3 SN - 0730-2312, 0730-2312 KW - RNA, Messenger KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Tretinoin KW - 5688UTC01R KW - Epidermal Growth Factor KW - 62229-50-9 KW - Transforming Growth Factors KW - 76057-06-2 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Drug Interactions KW - Tumor Cells, Cultured -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - RNA, Messenger -- drug effects KW - RNA, Messenger -- analysis KW - Epidermal Growth Factor -- pharmacology KW - Time Factors KW - Gene Expression -- drug effects KW - Tretinoin -- pharmacology KW - Triiodothyronine -- pharmacology KW - Receptor, Epidermal Growth Factor -- genetics KW - Breast Neoplasms -- metabolism KW - Transforming Growth Factors -- pharmacology KW - Receptor, Epidermal Growth Factor -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79441000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+biochemistry&rft.atitle=Modulation+of+transforming+growth+factor+alpha-dependent+expression+of+epidermal+growth+factor+receptor+gene+by+transforming+growth+factor+beta%2C+triiodothyronine%2C+and+retinoic+acid.&rft.au=Fernandez-Pol%2C+J+A%3BKlos%2C+D+J%3BHamilton%2C+P+D&rft.aulast=Fernandez-Pol&rft.aufirst=J&rft.date=1989-11-01&rft.volume=41&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+biochemistry&rft.issn=07302312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-05 N1 - Date created - 1990-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term increase in peritoneal membrane transport rates following incidental intraperitoneal sodium hypochlorite infusion. AN - 79390625; 2599671 AB - A patient on continuous ambulatory peritoneal dialysis using an "O" set connection system with sodium hypochlorite as a disinfectant incidentally infused the disinfectant intraperitoneally on two occasions. The product of peritoneal membrane permeability and peritoneal membrane surface area increased after both infusions as judged by peritoneal equilibration test results and/or serum chemistries. Elevated peritoneal solute transport rates and reduced ultrafiltration gradually subsided but did not return to preinfusion values. This observation suggests that intraperitoneal sodium hypochlorite infusion may cause significant long-term alteration in peritoneal membrane transport characteristics. JF - The International journal of artificial organs AU - Dedhia, N M AU - Schmidt, L M AU - Twardowski, Z J AU - Khanna, R AU - Nolph, K D AD - Dep. of Medicine, University of Missouri, Harry S. Truman Veterans Administration Hospital, Columbia. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 711 EP - 714 VL - 12 IS - 11 SN - 0391-3988, 0391-3988 KW - Dialysis Solutions KW - 0 KW - Sodium Hypochlorite KW - DY38VHM5OD KW - Index Medicus KW - Permeability -- drug effects KW - Humans KW - Middle Aged KW - Infusions, Parenteral KW - Male KW - Peritoneal Dialysis, Continuous Ambulatory KW - Sodium Hypochlorite -- poisoning KW - Sodium Hypochlorite -- administration & dosage KW - Peritoneum -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79390625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+artificial+organs&rft.atitle=Long-term+increase+in+peritoneal+membrane+transport+rates+following+incidental+intraperitoneal+sodium+hypochlorite+infusion.&rft.au=Dedhia%2C+N+M%3BSchmidt%2C+L+M%3BTwardowski%2C+Z+J%3BKhanna%2C+R%3BNolph%2C+K+D&rft.aulast=Dedhia&rft.aufirst=N&rft.date=1989-11-01&rft.volume=12&rft.issue=11&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+artificial+organs&rft.issn=03913988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-07 N1 - Date created - 1990-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancement of butyrate-induced differentiation of HT-29 human colon carcinoma cells by 1,25-dihydroxyvitamin D3. AN - 79389749; 2688649 AB - The individual and combined effects of sodium butyrate (NaB) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on inhibition of cell growth and initiation of enterocytic differentiation were investigated in established HT-29 human colonic adenocarcinoma cells. 1,25-(OH)2D3 alone caused some growth restriction but failed to induce differentiation of HT-29 carcinoma cells into a more benign enterocytic phenotype, as assessed by the appearance of mucin-producing colonocytes (goblet cells), increased alkaline phosphatase activity, and the generation of flat foci. NaB, in contrast, produced considerable biochemical and morphologic differentiation along the enterocyte maturation pathway. Combined exposure of HT-29 cells to both NaB and 1,25-(OH)2D3, however, significantly augmented the frequency of differentiated colonocytes, growth inhibition, extent of goblet cell maturation attained, in vitro "differentiation" response of human carcinoma cells is a complex process which, like normal cell maturation within the colonic crypts in vivo, is modulatable (both qualitatively and quantitatively) as a function of inducer composition. JF - Biochemical pharmacology AU - Tanaka, Y AU - Bush, K K AU - Klauck, T M AU - Higgins, P J AD - Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1989/11/01/ PY - 1989 DA - 1989 Nov 01 SP - 3859 EP - 3865 VL - 38 IS - 21 SN - 0006-2952, 0006-2952 KW - Butyrates KW - 0 KW - Mucins KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Calcitriol KW - FXC9231JVH KW - Index Medicus KW - Phenotype KW - Microscopy, Phase-Contrast KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Cell Division -- drug effects KW - Alkaline Phosphatase -- metabolism KW - Diet KW - Mucins -- biosynthesis KW - Drug Synergism KW - Cell Differentiation -- drug effects KW - Adenocarcinoma -- metabolism KW - Butyrates -- pharmacology KW - Colonic Neoplasms -- metabolism KW - Colonic Neoplasms -- pathology KW - Calcitriol -- pharmacology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79389749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Enhancement+of+butyrate-induced+differentiation+of+HT-29+human+colon+carcinoma+cells+by+1%2C25-dihydroxyvitamin+D3.&rft.au=Tanaka%2C+Y%3BBush%2C+K+K%3BKlauck%2C+T+M%3BHiggins%2C+P+J&rft.aulast=Tanaka&rft.aufirst=Y&rft.date=1989-11-01&rft.volume=38&rft.issue=21&rft.spage=3859&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-19 N1 - Date created - 1990-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cathepsin B and D activity in alveolar macrophages from rats with pulmonary granulomatous inflammation or acute lung injury. AN - 79389166; 2596377 AB - Cathepsin B and D activity was determined using specific synthetic substrates in alveolar macrophages (AMs) obtained from Sprague-Dawley rats with experimentally induced pulmonary granulomatous inflammation. Increased cathepsin B activity was found 4 days after intravenous injection of complete Freund's adjuvant (CFA), but not after injection of live bacillus Calmette-Guérin organisms (BCG), indicating that the enzyme response was unrelated to the subsequent development of granulomatous inflammation. Findings of comparable increases in enzyme activity following injection of mineral oil (MO) indicate that the response to CFA was due to the oil component. Significantly, oleic acid (OA), a natural fatty acid, did not stimulate enzyme activity although the agent, like MO, caused acute lung injury as assessed by 125I albumin uptake. At 7 and 28 days following injection of CFA, cathepsin B levels in AMs were the same as those in animals given normal saline (NS), although bronchoalveolar lavage (BAL) samples still contained increased numbers of AMs, and cells obtained at 28 days phagocytosed more polystyrene microspheres. Cathepsin D activity did not increase 4 days after injection of CFA or BCG + CFA; at 28 days following injection of BCG + CFA activity was significantly decreased as compared to animals given NS. The data reveal a differential response of two lysosomal enzymes during the early phases of granulomatous inflammation. JF - Agents and actions AU - Lesser, M AU - Chang, J C AU - Galicki, N I AU - Edelman, J AU - Cardozo, C AD - Pulmonary Division, Bronx Veterans Administration Medical Center, New York, NY 10468. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 264 EP - 271 VL - 28 IS - 3-4 SN - 0065-4299, 0065-4299 KW - Albumins KW - 0 KW - Cathepsins KW - EC 3.4.- KW - Cathepsin B KW - EC 3.4.22.1 KW - Cathepsin D KW - EC 3.4.23.5 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Cathepsin D -- metabolism KW - Animals KW - Albumins -- pharmacokinetics KW - Pulmonary Alveoli -- enzymology KW - Pulmonary Alveoli -- cytology KW - Cathepsin B -- metabolism KW - Phagocytosis KW - Inflammation -- enzymology KW - Male KW - Inflammation -- pathology KW - Macrophages -- enzymology KW - Lung Diseases -- chemically induced KW - Granuloma -- enzymology KW - Granuloma -- pathology KW - Lung Diseases -- pathology KW - Lung Diseases -- enzymology KW - Cathepsins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79389166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agents+and+actions&rft.atitle=Cathepsin+B+and+D+activity+in+alveolar+macrophages+from+rats+with+pulmonary+granulomatous+inflammation+or+acute+lung+injury.&rft.au=Lesser%2C+M%3BChang%2C+J+C%3BGalicki%2C+N+I%3BEdelman%2C+J%3BCardozo%2C+C&rft.aulast=Lesser&rft.aufirst=M&rft.date=1989-11-01&rft.volume=28&rft.issue=3-4&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Agents+and+actions&rft.issn=00654299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 24-hour blood pressure recordings in Dahl rats on high- and low-salt diets. AN - 79359218; 2589547 AB - The goal of this study was to determine if the baroreflex abnormality previously shown in Dahl-sensitive (DS) rats would increase blood pressure and heart rate (HR) variability. Mean arterial pressure (MAP) and HR were sampled every 2 s for 24 h from Dahl-resistant (DR) and DS rats on low- and high-salt diets (n = 12-13 in each group). MAP +/- SD was significantly elevated in the DS rats on high-salt diets (DSH); the SD of MAP in the DSH rats was also significantly higher compared with similar measurements in rats on high-salt diets (DRH) and DS rats on low-salt diets (DSL) when SD was divided by MAP. MAP was higher at night than during the day in the DSH rats. In contrast, HR and HR variability were not significantly different between the groups. The baroreflex control of HR, determined by means of graded injections of phenylephrine, was least in the DSH rats and increased, respectively, with DSL rats, DRH rats, and DR rats on low-salt diets. There was no significant correlation between the baroreflex control of HR and MAP or the SD of MAP in the DSH rats, suggesting that there is not a simple relationship between baroreflex gain and the overall behavior of MAP in DSH rats. JF - The American journal of physiology AU - Brown, D R AU - Morgan, D A AU - Peuler, J D AU - Thoren, P AD - Department of Internal Medicine, Veterans Administration Hospital, Iowa City, Iowa 52242. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - R1225 EP - R1231 VL - 257 IS - 5 Pt 2 SN - 0002-9513, 0002-9513 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reflex -- physiology KW - Heart Rate KW - Pressoreceptors -- physiology KW - Drug Resistance KW - Female KW - Hypertension -- chemically induced KW - Diet, Sodium-Restricted KW - Circadian Rhythm KW - Blood Pressure KW - Sodium Chloride -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79359218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=24-hour+blood+pressure+recordings+in+Dahl+rats+on+high-+and+low-salt+diets.&rft.au=Brown%2C+D+R%3BMorgan%2C+D+A%3BPeuler%2C+J+D%3BThoren%2C+P&rft.aulast=Brown&rft.aufirst=D&rft.date=1989-11-01&rft.volume=257&rft.issue=5+Pt+2&rft.spage=R1225&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-28 N1 - Date created - 1989-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Current HIV therapy: an update on zidovudine. AN - 79352038; 2685670 JF - The Nurse practitioner AU - Lynn, M M AU - Holdcroft, C AD - Outpatient Primary Care Clinics, Denver Veterans Administration Medical Center. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 52 EP - 52, 54, 56 VL - 14 IS - 11 SN - 0361-1817, 0361-1817 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Nursing KW - AIDS/HIV KW - Humans KW - Quality of Life KW - Zidovudine -- therapeutic use KW - Zidovudine -- adverse effects KW - Zidovudine -- pharmacology KW - HIV Infections -- drug therapy KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79352038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Current+HIV+therapy%3A+an+update+on+zidovudine.&rft.au=Lynn%2C+M+M%3BHoldcroft%2C+C&rft.aulast=Lynn&rft.aufirst=M&rft.date=1989-11-01&rft.volume=14&rft.issue=11&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-11 N1 - Date created - 1990-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radon: detection and treatment. AN - 79349515; 2586859 AB - Within the last few years, natural radon exposure in non-industrial settings, primarily homes, has become a health concern. Research has demonstrated that many homes throughout the United States have radon concentrations much higher than the legal federal limits set for miners. Thousands of unsuspecting people are being exposed to high levels of radiation. It is estimated that up to 15 percent of lung cancers are caused from radon. This is a significant health risk. With basic knowledge of the current information on radon, a primary health care provider can address patients' radon concerns and make appropriate referrals. JF - The Nurse practitioner AU - Loken, S AU - Loken, T AD - Salt Lake City Veterans Administration Medical Center, Utah. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 45 EP - 6, 48, 51 VL - 14 IS - 11 SN - 0361-1817, 0361-1817 KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Nursing KW - United States KW - Environmental Monitoring KW - Humans KW - Environmental Exposure KW - Health Status Indicators KW - Housing KW - Lung Neoplasms -- chemically induced KW - Radon -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79349515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Radon%3A+detection+and+treatment.&rft.au=Loken%2C+S%3BLoken%2C+T&rft.aulast=Loken&rft.aufirst=S&rft.date=1989-11-01&rft.volume=14&rft.issue=11&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-11 N1 - Date created - 1990-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The efficacy of L-tryptophan in the reduction of sleep disturbance and depressive state in alcoholic patients. AN - 79342407; 2685471 AB - Alcoholic male inpatients (N = 76) served as subjects in this study which examined the effect of L-tryptophan on depressive state and sleep disturbance. All subjects were residents of a 6-week alcohol treatment program at a Veterans Administration Medical Center. Subjects' degree of depression (Zung's Depression Scale) and sleep satisfaction (Webb's Post-Sleep Inventory) were measured four times during the study, just prior to and following ingestion of a substance that was either 3 gms L-tryptophan or 3 gms of an identical-appearing placebo. Subjects in the L-tryptophan/placebo condition received the active substance for 4 days followed by the placebo with a 4-day washout period in between. A second group of subjects received the same regimen of reverse order and a third received placebos on both occasions. There were two additional control groups that received no substances. All subjects in the study reported decreased levels of depression due to nonspecific treatment effects. The subjects who took L-tryptophan in either sequence reported even lower levels of depression. Sleep disturbance was not affected by L-tryptophan since it was barely present when the study began. A phenomenon referred to as the interval effect is discussed and an alternative explanation for this effect is offered. JF - Journal of studies on alcohol AU - Asheychik, R AU - Jackson, T AU - Baker, H AU - Ferraro, R AU - Ashton, T AU - Kilgore, J AD - Veterans Administration Medical Center, Roseburg, Oregon 97470. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 525 EP - 532 VL - 50 IS - 6 SN - 0096-882X, 0096-882X KW - Tryptophan KW - 8DUH1N11BX KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Middle Aged KW - Sleep Stages -- drug effects KW - Male KW - Sleep Initiation and Maintenance Disorders -- rehabilitation KW - Alcoholism -- rehabilitation KW - Tryptophan -- administration & dosage KW - Depressive Disorder -- psychology KW - Sleep Initiation and Maintenance Disorders -- psychology KW - Alcoholism -- psychology KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79342407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=The+efficacy+of+L-tryptophan+in+the+reduction+of+sleep+disturbance+and+depressive+state+in+alcoholic+patients.&rft.au=Asheychik%2C+R%3BJackson%2C+T%3BBaker%2C+H%3BFerraro%2C+R%3BAshton%2C+T%3BKilgore%2C+J&rft.aulast=Asheychik&rft.aufirst=R&rft.date=1989-11-01&rft.volume=50&rft.issue=6&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-26 N1 - Date created - 1989-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Future possibilities for psychiatry. AN - 79341360; 2586102 JF - Journal of studies on alcohol AU - Schuckit, M A AD - Alcohol Research Center, San Diego Veterans Administration Medical Center. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 501 EP - 502 VL - 50 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - United States KW - Humans KW - Forecasting KW - Alcoholism -- rehabilitation KW - Psychiatry -- trends KW - Alcoholism -- psychology KW - Referral and Consultation -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79341360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Future+possibilities+for+psychiatry.&rft.au=Schuckit%2C+M+A&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1989-11-01&rft.volume=50&rft.issue=6&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-26 N1 - Date created - 1989-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of therapeutic digoxin antibodies on digoxin assays. AN - 79331881; 2684090 AB - The introduction of therapeutic digoxin antibodies in the treatment of digoxin toxicity has resulted in spurious results in the many assays of cardioglycoside in serum of patients receiving this therapy. An evaluation of currently used assay methods was incorporated into a pilot Ligand Assay Survey Program of the College of American Pathologists to define which assays were unaltered by the presence of a therapeutic digoxin antibody (Digibind). Disparity of affinity constants of the therapeutic and kit antibodies is the most likely explanation for erroneous values. Specific methods are defined that appear to be free of this phenomenon. JF - Archives of pathology & laboratory medicine AU - Hansell, J R AD - Nuclear Medicine Service, Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1259 EP - 1262 VL - 113 IS - 11 SN - 0003-9985, 0003-9985 KW - Immunoglobulin Fab Fragments KW - 0 KW - digoxin antibodies Fab fragments KW - Digoxin KW - 73K4184T59 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Fluorescent Antibody Technique KW - Immunoassay KW - Immunoglobulin Fab Fragments -- therapeutic use KW - Digoxin -- immunology KW - Digoxin -- analysis KW - Digoxin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79331881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=Effect+of+therapeutic+digoxin+antibodies+on+digoxin+assays.&rft.au=Hansell%2C+J+R&rft.aulast=Hansell&rft.aufirst=J&rft.date=1989-11-01&rft.volume=113&rft.issue=11&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=00039985&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-01 N1 - Date created - 1989-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Snipping the thread of life. Antimuscarinic side effects of medications in the elderly. AN - 79327344; 2684071 AB - Drugs with antimuscarinic activity are used for a wide variety of medical conditions. Unfortunately, side effects that develop as a result of muscarinic blockade are common and their frequency and clinical significance appear to increase with advanced age. Nevertheless, such drugs are frequently prescribed to elderly persons, particularly to those living in nursing homes. This review details the prevalence of antimuscarinic drug use in the elderly, the classes of drugs that exhibit antimuscarinic activity, organ-specific effects of muscarinic blockade, side effects identified in elderly individuals, and strategies to prevent or treat complications of antimuscarinic therapy, including recent advances in the development of drugs with selective activity for specific subclasses of muscarinic receptors. JF - Archives of internal medicine AU - Peters, N L AD - Veterans Administration Medical Center, Denver, Colo. 80220. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 2414 EP - 2420 VL - 149 IS - 11 SN - 0003-9926, 0003-9926 KW - Parasympatholytics KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Digestive System -- drug effects KW - Urogenital System -- drug effects KW - Skin -- drug effects KW - Humans KW - Nervous System -- drug effects KW - Heart -- drug effects KW - Aged KW - Eye -- drug effects KW - Parasympatholytics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79327344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Snipping+the+thread+of+life.+Antimuscarinic+side+effects+of+medications+in+the+elderly.&rft.au=Peters%2C+N+L&rft.aulast=Peters&rft.aufirst=N&rft.date=1989-11-01&rft.volume=149&rft.issue=11&rft.spage=2414&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-06 N1 - Date created - 1989-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amlodipine versus nadolol in patients with stable angina pectoris. AN - 79323277; 2530878 JF - American heart journal AU - Singh, S AU - Doherty, J AU - Udhoji, V AU - Smith, K AU - Gorwit, J AU - Bekheit, S AU - Mather, S AU - Stein, W AU - San Fellippo, J AU - Hearan, P AD - Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1137 EP - 1138 VL - 118 IS - 5 Pt 2 SN - 0002-8703, 0002-8703 KW - Calcium Channel Blockers KW - 0 KW - Amlodipine KW - 1J444QC288 KW - Nadolol KW - 42200-33-9 KW - Nifedipine KW - I9ZF7L6G2L KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test KW - Drug Administration Schedule KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Time Factors KW - Nadolol -- therapeutic use KW - Nadolol -- adverse effects KW - Nifedipine -- administration & dosage KW - Nadolol -- administration & dosage KW - Nifedipine -- analogs & derivatives KW - Angina Pectoris -- drug therapy KW - Nifedipine -- therapeutic use KW - Nifedipine -- adverse effects KW - Angina Pectoris -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79323277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Amlodipine+versus+nadolol+in+patients+with+stable+angina+pectoris.&rft.au=Singh%2C+S%3BDoherty%2C+J%3BUdhoji%2C+V%3BSmith%2C+K%3BGorwit%2C+J%3BBekheit%2C+S%3BMather%2C+S%3BStein%2C+W%3BSan+Fellippo%2C+J%3BHearan%2C+P&rft.aulast=Singh&rft.aufirst=S&rft.date=1989-11-01&rft.volume=118&rft.issue=5+Pt+2&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-06 N1 - Date created - 1989-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients. AN - 79322163; 2816969 AB - We performed a prospective clinical study of 200 consecutive patients with Pseudomonas aeruginosa bacteremias to analyze in vitro susceptibility and synergistic testing of antibiotics the patients received and clinical parameters to assess their relationship to survival. No significant correlation between in vitro susceptibility testing (minimal inhibitory concentrations/minimal bactericidal concentrations) and outcome could be demonstrated. Similarly, improved outcome could not be demonstrated for patients receiving antibiotic combinations that were synergistic in vitro (either time-kill or checker-board) versus those combinations that were not. There was also no correlation between results obtained by time-kill curve and checkerboard synergistic testing, i.e., combinations found to be synergistic by one method were not necessarily synergistic by the other method. Clinical parameters associated with improved survival were a urinary portal of entry and absence of neutropenia. Conversely, survival was significantly decreased when the portal was the respiratory tract. The mortality rate between patients receiving combination therapy (27%) and monotherapy (47%) was significant (p less than 0.02); this significant relationship held true for most subgroups including malignancy, nosocomial infection, and infection site. Increasing effort should be placed on ensuring timely administration of combination therapy to patients with P. aeruginosa bacteremia since the use of combination therapy was even more important in determining outcome than was underlying disease. JF - The American journal of medicine AU - Hilf, M AU - Yu, V L AU - Sharp, J AU - Zuravleff, J J AU - Korvick, J A AU - Muder, R R AD - Infectious Disease Section, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 540 EP - 546 VL - 87 IS - 5 SN - 0002-9343, 0002-9343 KW - Anti-Bacterial Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Humans KW - Prognosis KW - Infant, Newborn KW - Drug Resistance, Microbial KW - Aged KW - Child KW - Multivariate Analysis KW - Child, Preschool KW - Drug Therapy, Combination KW - Infant KW - Prospective Studies KW - Aged, 80 and over KW - Adult KW - Cross Infection -- drug therapy KW - Middle Aged KW - Adolescent KW - Pseudomonas Infections -- drug therapy KW - Anti-Bacterial Agents -- therapeutic use KW - Sepsis -- drug therapy KW - Sepsis -- mortality KW - Sepsis -- microbiology KW - Pseudomonas Infections -- microbiology KW - Pseudomonas Infections -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79322163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Antibiotic+therapy+for+Pseudomonas+aeruginosa+bacteremia%3A+outcome+correlations+in+a+prospective+study+of+200+patients.&rft.au=Hilf%2C+M%3BYu%2C+V+L%3BSharp%2C+J%3BZuravleff%2C+J+J%3BKorvick%2C+J+A%3BMuder%2C+R+R&rft.aulast=Hilf&rft.aufirst=M&rft.date=1989-11-01&rft.volume=87&rft.issue=5&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-11 N1 - Date created - 1989-12-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Med. 1991 Jan;90(1):134 [1986584] Am J Med. 1991 Jan;90(1):135 [1986585] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenylephrine-induced hypertension reduces ischemia following middle cerebral artery occlusion in rats. AN - 79307316; 2815189 AB - We studied the influence of phenylephrine-induced hypertension on the area of ischemia during brief middle cerebral artery occlusion. Rats were anesthetized with 1.2 minimal alveolar concentration (MAC) isoflurane, and the middle cerebral artery was occluded via a subtemporal craniectomy. Immediately thereafter, in one group (n = 9) arterial blood pressure was increased 30-35 mm Hg above the preocclusion level by intravenous infusion of phenylephrine. In a second, control, group (n = 10) there was no manipulation of blood pressure. Local cerebral blood flow was determined autoradiographically 15 minutes after occlusion. The areas (expressed as a percentage of the total coronal cross-sectional area) in which local cerebral blood flow decreased to three ranges (0-6 ml/100 g/min [rapid neuronal death probable], 6-15 ml/100 g/min [delayed neuronal death probable], and 15-23 ml/100 g/min [electrophysiologic dysfunction with prolonged survival probable]) were measured. The areas in which local cerebral blood flow decreased to the two more severely ischemic ranges were smaller in the phenylephrine group than in the control group. For example, in the coronal section in the center of the middle cerebral artery distribution, local cerebral blood flow was 0-6 ml/100 g/min in 6.7 +/- 1.4% of the section in normotensive rats but was in that range in only 1.7 +/- 0.6% of the section during phenylephrine-induced hypertension (p less than 0.05). For the 6-15 ml/100 g/min range, the areas were 6.8 +/- 0.8% and 3.8 +/- 0.7%, respectively (p less than 0.05). For the 15-23 ml/100 g/min range, there were no differences between groups.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Stroke AU - Drummond, J C AU - Oh, Y S AU - Cole, D J AU - Shapiro, H M AD - Department of Anesthesia, Veterans Administration Medical Center, San Diego, CA. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1538 EP - 1544 VL - 20 IS - 11 SN - 0039-2499, 0039-2499 KW - Phenylephrine KW - 1WS297W6MV KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Blood Flow Velocity KW - Constriction KW - Cerebrovascular Circulation KW - Male KW - Ischemic Attack, Transient -- prevention & control KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Ischemic Attack, Transient -- etiology KW - Cerebral Arteries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79307316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Phenylephrine-induced+hypertension+reduces+ischemia+following+middle+cerebral+artery+occlusion+in+rats.&rft.au=Drummond%2C+J+C%3BOh%2C+Y+S%3BCole%2C+D+J%3BShapiro%2C+H+M&rft.aulast=Drummond&rft.aufirst=J&rft.date=1989-11-01&rft.volume=20&rft.issue=11&rft.spage=1538&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-11 N1 - Date created - 1989-12-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Stroke. 1990 May;21(5):827 [2386567] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Augmented bicarbonate reabsorption by both the proximal and distal nephron maintains chloride-deplete metabolic alkalosis in rats. AN - 79295599; 2808701 AB - Whether augmented bicarbonate reabsorption by renal tubular epithelium contributes to the maintenance of chloride-deplete metabolic alkalosis is not clear. This study used free-flow micropuncture to investigate bicarbonate reabsorption by surface nephron segments in a rat model of diuretic-induced alkalosis compared to control. The proximal and distal nephron of the alkalotic animals had higher values for both delivered load to and absolute reabsorption from these segments. The proximal tubules of alkalotic and control animals had similar values for the slopes of the linear regression of delivered load vs. reabsorption and for the bicarbonate tubular fluid to plasma (TF/P) ratio at the late proximal tubule. By contrast, the corresponding analysis for the distal segment of alkalotic animals revealed a greater slope (0.98 vs. 0.81, P less than 0.003) and a smaller bicarbonate TF/P ratio at the late distal tubule (0.10 vs. 0.16, P less than 0.006). The data indicate that augmented bicarbonate reabsorption by both the proximal and distal nephron contributes to maintaining the alkalosis of this model. The data suggest primary stimulation of bicarbonate reabsorption in the distal nephron and load-dependent reabsorption in the proximal tubule. JF - The Journal of clinical investigation AU - Wesson, D E AD - Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas 77211. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1460 EP - 1469 VL - 84 IS - 5 SN - 0021-9738, 0021-9738 KW - Bicarbonates KW - 0 KW - Chlorides KW - Electrolytes KW - Furosemide KW - 7LXU5N7ZO5 KW - Inulin KW - 9005-80-5 KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blood Pressure KW - Arteries KW - Muscles -- metabolism KW - Disease Models, Animal KW - Potassium -- metabolism KW - Electrolytes -- blood KW - Rats, Inbred Strains KW - Rats KW - Inulin -- metabolism KW - Absorption KW - Acid-Base Equilibrium -- physiology KW - Female KW - Male KW - Alkalosis -- chemically induced KW - Kidney Tubules, Proximal -- metabolism KW - Kidney Tubules, Distal -- metabolism KW - Kidney Tubules -- metabolism KW - Chlorides -- metabolism KW - Bicarbonates -- metabolism KW - Alkalosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79295599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Augmented+bicarbonate+reabsorption+by+both+the+proximal+and+distal+nephron+maintains+chloride-deplete+metabolic+alkalosis+in+rats.&rft.au=Wesson%2C+D+E&rft.aulast=Wesson&rft.aufirst=D&rft.date=1989-11-01&rft.volume=84&rft.issue=5&rft.spage=1460&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Sci. 1965 Aug;29(1):159-70 [5825198] Am J Physiol. 1988 Jul;255(1 Pt 2):F182-7 [3394809] Pflugers Arch. 1970;318(2):147-75 [5464606] Pflugers Arch. 1972;331(1):13-24 [5063259] Pflugers Arch. 1972;331(3):215-25 [5063522] Kidney Int. 1972 May;1(5):306-21 [4600132] Anal Chem. 1975 Apr;47(4):765-7 [1137152] J Clin Invest. 1979 Nov;64(5):1168-80 [500804] Kidney Int. 1981 Jul;20(1):18-28 [7300109] Am J Physiol. 1982 May;242(5):F532-43 [6282141] J Membr Biol. 1982;69(2):159-65 [7131537] Am J Physiol. 1983 Feb;244(2):F217-21 [6824081] J Clin Invest. 1983 Mar;71(3):736-46 [6826733] J Clin Invest. 1983 May;71(5):1141-60 [6853706] Am J Physiol. 1983 Oct;245(4):F478-84 [6414312] J Clin Invest. 1983 Oct;72(4):1385-95 [6415109] J Membr Biol. 1984;79(2):153-61 [6086932] J Clin Invest. 1986 Mar;77(3):709-16 [3949975] Pflugers Arch. 1986 Aug;407(2):221-7 [3748784] J Clin Invest. 1986 Dec;78(6):1547-57 [3782470] J Clin Invest. 1986 Dec;78(6):1558-67 [3097074] Kidney Int. 1987 Aug;32(2):238-45 [3656936] Am J Physiol. 1987 Oct;253(4 Pt 2):F726-33 [3661722] Am J Physiol. 1987 Nov;253(5 Pt 2):F1031-9 [3688234] Am J Physiol. 1987 Nov;253(5 Pt 2):F912-6 [3688241] J Clin Invest. 1970 Mar;49(3):586-95 [5415684] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. AN - 79294944; 2553777 AB - Leukotriene B4 (LTB4) is a major product of human alveolar macrophages and has potent chemotactic activity for neutrophils (PMN) in vitro. To evaluate the effects of LTB4 in the normal human lung, we instilled LTB4 (5 X 10(-7)M, 10 ml) into a subsegment of the right middle lobe and 0.9% NaCl (10 ml) into a subsegment of the lingula using a fiberoptic bronchoscope in 12 healthy human volunteers. 4 h later, we performed bronchoalveolar lavage of the same subsegments. Compared with the NaCl instillation, LTB4 caused a large increase in lavage total cells (NaCl = 6.8 +/- 1.0 X 10(6) vs. LTB4 = 26.4 +/- 5.0 X 10(6), P less than 0.01), most of which were PMN (NaCl = 12.2 +/- 4.6% vs. LTB4 = 55.7 +/- 6.0%, P less than 0.001). In contrast, there was only a small increase in lavage total protein, and the lavage total protein correlated weakly with lavage total cells and PMN. The production of superoxide anion by the lavage PMN in response to phorbol myristate acetate was similar to that of peripheral blood PMN. The migration of lavage PMN was normal toward the chemotactic peptide FMLP, but reduced toward LTB4 and zymosan-activated human serum. Morphometric analysis using transmission electron microscopy indicated a selective loss of small granules in the lung neutrophils as compared with peripheral blood neutrophils. The data indicate that in the normal human lung, LTB4 can recruit active PMN into the airspaces without causing a significant change in the protein permeability of the epithelial barrier. JF - The Journal of clinical investigation AU - Martin, T R AU - Pistorese, B P AU - Chi, E Y AU - Goodman, R B AU - Matthay, M A AD - Medical Research Service of the Seattle Veterans Administration Medical Center, Washington 98108. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1609 EP - 1619 VL - 84 IS - 5 SN - 0021-9738, 0021-9738 KW - Proteins KW - 0 KW - Superoxides KW - 11062-77-4 KW - Leukotriene B4 KW - 1HGW4DR56D KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Movement KW - Superoxides -- metabolism KW - Bronchoalveolar Lavage Fluid -- analysis KW - Cell Membrane Permeability -- drug effects KW - Humans KW - Adult KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Microscopy, Electron KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Female KW - Neutrophils -- drug effects KW - Neutrophils -- cytology KW - Lung -- cytology KW - Pulmonary Alveoli -- cytology KW - Lung -- drug effects KW - Leukotriene B4 -- pharmacology KW - Lung -- metabolism KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79294944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Effects+of+leukotriene+B4+in+the+human+lung.+Recruitment+of+neutrophils+into+the+alveolar+spaces+without+a+change+in+protein+permeability.&rft.au=Martin%2C+T+R%3BPistorese%2C+B+P%3BChi%2C+E+Y%3BGoodman%2C+R+B%3BMatthay%2C+M+A&rft.aulast=Martin&rft.aufirst=T&rft.date=1989-11-01&rft.volume=84&rft.issue=5&rft.spage=1609&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostaglandins. 1983 Feb;25(2):281-9 [6304818] J Appl Physiol (1985). 1988 Jun;64(6):2605-13 [3403445] J Immunol. 1983 Dec;131(6):2913-8 [6644024] J Cell Physiol. 1984 Jan;118(1):13-8 [6317702] J Invest Dermatol. 1984 Jan;82(1):9-12 [6317764] J Clin Invest. 1986 Jan;77(1):61-5 [3003155] Am Rev Respir Dis. 1986 Feb;133(2):218-25 [3004270] J Clin Invest. 1986 Mar;77(3):925-33 [3005369] Blood. 1986 Apr;67(4):1007-13 [2420394] Int J Biomed Comput. 1986 May;18(3-4):183-92 [3013781] J Clin Invest. 1986 Dec;78(6):1513-22 [2431002] Blood. 1987 Feb;69(2):605-10 [3026524] J Biol Chem. 1987 Apr 25;262(12):5576-80 [3553180] J Immunol. 1987 May 15;138(10):3396-402 [3033073] Am Rev Respir Dis. 1984 Jan;129(1):106-11 [6322626] J Clin Invest. 1984 Apr;73(4):889-97 [6323538] J Biol Chem. 1984 May 10;259(9):5430-9 [6371005] Tissue Cell. 1984;16(2):137-55 [6740645] J Clin Invest. 1984 Oct;74(4):1280-90 [6480827] Blood Cells. 1984;10(1):45-57 [6487814] Fed Proc. 1985 Jan;44(1 Pt 1):30-5 [2981731] J Immunol. 1985 May;134(5):3356-63 [2984287] Am Rev Respir Dis. 1985 Apr;131(4):624-32 [2986502] J Cell Sci. 1985 Feb;73:33-48 [2991305] Am Rev Respir Dis. 1985 Aug;132(2):254-60 [4026050] J Appl Physiol (1985). 1985 Sep;59(3):928-34 [4055578] Scand J Clin Lab Invest Suppl. 1968;97:77-89 [4179068] J Clin Invest. 1973 Jul;52(7):1632-5 [4578156] Am J Pathol. 1974 Oct;77(1):41-66 [4447123] Clin Exp Immunol. 1977 Jan;27(1):152-8 [321156] J Immunol. 1979 Jul;123(1):285-94 [448150] Biochem Biophys Res Commun. 1979 Mar 15;87(1):292-9 [378221] J Biol Chem. 1979 Aug 25;254(16):7865-9 [468794] J Immunol Methods. 1980;33(3):239-47 [6989919] Nature. 1980 Jul 17;286(5770):264-5 [6250050] J Exp Med. 1981 Feb 1;153(2):482-7 [6264017] Science. 1981 Aug 21;213(4510):830-7 [6266014] Blood. 1981 Sep;58(3):658-61 [6266432] J Immunol. 1981 Sep;127(3):839-44 [6790618] J Immunol Methods. 1981;46(2):211-26 [6273471] J Clin Invest. 1982 Mar;69(3):543-53 [7037851] Am Rev Respir Dis. 1982 Apr;125(4):443-7 [7073114] Inflammation. 1982 Jun;6(2):189-200 [6179872] J Clin Invest. 1982 Oct;70(4):699-706 [6956584] Lab Invest. 1982 Dec;47(6):579-85 [6815379] J Invest Dermatol. 1983 Feb;80(2):115-9 [6296237] Proc Natl Acad Sci U S A. 1982 Dec;79(24):7866-70 [6296853] J Periodontal Res. 1982 Nov;17(6):614-25 [6219209] Am Rev Respir Dis. 1987 May;135(5):1020-6 [3034108] Am Rev Respir Dis. 1987 May;135(5):1176-85 [3107445] J Clin Invest. 1987 Oct;80(4):1114-24 [2821074] Am Rev Respir Dis. 1987 Oct;136(4):930-4 [2821855] J Exp Med. 1987 Dec 1;166(6):1641-53 [2824654] J Clin Invest. 1988 Mar;81(3):676-82 [3278004] Microvasc Res. 1988 Jan;35(1):27-47 [2830471] J Biol Chem. 1983 Nov 25;258(22):13522-7 [6315700] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lymphoma in a black patient with actinic reticuloid treated with PUVA: possible etiologic considerations. AN - 79294506; 2808846 AB - A 47-year-old black man with a chronic photocontact dermatitis that evolved into actinic reticuloid was treated with systemically administered PUVA for 15 months. Subsequently an isolated nodule of non-mycosis fungoides T cell lymphoma developed. The use of PUVA may have predisposed this patient to the development of a frank malignancy. JF - Journal of the American Academy of Dermatology AU - Ashinoff, R AU - Buchness, M R AU - Lim, H W AD - Dermatology Service, New York Veterans Administration Medical Center, New York, NY 10010. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1134 EP - 1137 VL - 21 IS - 5 Pt 2 SN - 0190-9622, 0190-9622 KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - T-Lymphocytes KW - PUVA Therapy -- adverse effects KW - Skin Neoplasms -- chemically induced KW - Lymphoma -- chemically induced KW - Photosensitivity Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79294506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Lymphoma+in+a+black+patient+with+actinic+reticuloid+treated+with+PUVA%3A+possible+etiologic+considerations.&rft.au=Ashinoff%2C+R%3BBuchness%2C+M+R%3BLim%2C+H+W&rft.aulast=Ashinoff&rft.aufirst=R&rft.date=1989-11-01&rft.volume=21&rft.issue=5+Pt+2&rft.spage=1134&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regenerative enzyme activity of the liver after partial hepatectomy or toxic injury depressed by continuous NH4+ infusion. AN - 79292193; 2809396 AB - Persistent slight or modest increments in blood ammonia level resulting from continuous intravenous infusion of NH4+ depressed hepatic thymidine kinase (TK) activity (DNA synthesis) by 30% after two-lobe (70%) hepatectomy, by 32% after subtotal (90%) hepatectomy, by 80% after massive injury with 1400 mg/kg acetaminophen, and by 92% after massive injury with 1000 mg/kg galactosamine. Ornithine decarboxylase activity (reflecting initiation of regeneration) was similarly depressed by 65% after 70% hepatectomy, by 58% after acetaminophen, and by 87% after galactosamine. It was not depressed after 90% hepatectomy. Intermittent marked but transient increments in blood ammonia level resulted in similar but slightly smaller enzyme reductions after the injuries with the toxins, and a reduction of 92% in TK activity after 70% hepatectomy. Thus, after toxic injury, both regenerative enzymes were substantially depressed by excess ammonia, whether present transiently in large amounts or persistently in small amounts. After partial hepatectomy, TK activity was similarly depressed by the large transient amounts of ammonia but was less affected by the persistent smaller amounts. JF - The Journal of laboratory and clinical medicine AU - Zieve, L AD - Veterans Administration Medical Center, University of Minnesota, Minneapolis. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 527 EP - 530 VL - 114 IS - 5 SN - 0022-2143, 0022-2143 KW - Ornithine Decarboxylase Inhibitors KW - 0 KW - Ammonium Chloride KW - 01Q9PC255D KW - Acetaminophen KW - 362O9ITL9D KW - Galactosamine KW - 7535-00-4 KW - Ammonia KW - 7664-41-7 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Ornithine Decarboxylase -- metabolism KW - Animals KW - Ammonia -- blood KW - Thymidine Kinase -- metabolism KW - Thymidine Kinase -- antagonists & inhibitors KW - Male KW - Ammonium Chloride -- administration & dosage KW - Liver -- enzymology KW - Galactosamine -- toxicity KW - Liver -- drug effects KW - Hepatectomy KW - Liver Regeneration KW - Ammonium Chloride -- pharmacology KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79292193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Regenerative+enzyme+activity+of+the+liver+after+partial+hepatectomy+or+toxic+injury+depressed+by+continuous+NH4%2B+infusion.&rft.au=Zieve%2C+L&rft.aulast=Zieve&rft.aufirst=L&rft.date=1989-11-01&rft.volume=114&rft.issue=5&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-15 N1 - Date created - 1989-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Serotonin depletion potentiates gastric secretory and motor responses to vagal but not peripheral gastric stimulants. AN - 79291381; 2572692 AB - Vagal stimulation is known to release gastrointestinal serotonin. The effect of depletion of serotonin stores on vagally stimulated gastric acid secretion and motility was studied in rats. Pretreatment of rats with parachlorophenylalanine (p-CPA) did not alter basal gastric acid and serotonin secretion but produced a 57% reduction in the intraluminal gastric release of serotonin and a 43 to 100% potentiation of the gastric acid secretory response elicited by intracisternal injection of the stable thyrotropin-releasing hormone analog, RX 77368, in conscious pylorus-ligated rats or urethane-anesthetized rats with an acute gastric fistula. Dose-response studies revealed that the gastric acid secretion induced by submaximal but not high doses of RX 77368 was elevated significantly by p-CPA pretreatment. p-CPA also enhanced the gastric acid output produced by submaximal, but not high doses of the vagal stimulant baclofen, [beta-(p-chlorophenyl)-gamma-aminobutyric acid]. In contrast, p-CPA pretreatment had no effect on gastric acid secretion stimulated by bethanechol, histamine or pentagastrin. Selective depletion of central serotonin stores by pretreatment with the neurotoxin 5,7-dihydroxytryptamine given alone, or combined with parachloroamphetamine did not alter RX 77368-stimulated gastric acid secretion. In addition, gastric contractility stimulated by intracisternal injection of RX 77368 was significantly enhanced by p-CPA but not by 5,7-dihydroxytryptamine pretreatment, whereas the contractile response to carbachol was not altered by p-CPA pretreatment. These results suggest that depletion of peripheral but not central serotonergic stores potentiate gastric acid secretion and contractility induced by vagally, but not peripherally acting gastric stimulants. Thus, peripheral serotonin may exert an inhibitory tone on vagally stimulated gastric acid secretion and motility in the rat. JF - The Journal of pharmacology and experimental therapeutics AU - Stephens, R L AU - Garrick, T AU - Weiner, H AU - Taché, Y AD - Center for Ulcer Research and Education, Veterans' Administration Medical Center, Los Angeles, California. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 524 EP - 530 VL - 251 IS - 2 SN - 0022-3565, 0022-3565 KW - Bethanechol Compounds KW - 0 KW - Bethanechol KW - 004F72P8F4 KW - Serotonin KW - 333DO1RDJY KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide KW - 76820-40-1 KW - Baclofen KW - H789N3FKE8 KW - Fenclonine KW - R5J7E3L9SP KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Bethanechol Compounds -- pharmacology KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Animals KW - Pyrrolidonecarboxylic Acid -- analogs & derivatives KW - Male KW - Baclofen -- pharmacology KW - Fenclonine -- pharmacology KW - Vagus Nerve -- physiology KW - Serotonin -- physiology KW - Gastrointestinal Motility -- drug effects KW - Gastric Acid -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79291381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Serotonin+depletion+potentiates+gastric+secretory+and+motor+responses+to+vagal+but+not+peripheral+gastric+stimulants.&rft.au=Stephens%2C+R+L%3BGarrick%2C+T%3BWeiner%2C+H%3BTach%C3%A9%2C+Y&rft.aulast=Stephens&rft.aufirst=R&rft.date=1989-11-01&rft.volume=251&rft.issue=2&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Myocardial glutathione depletion impairs recovery after short periods of ischemia. AN - 79283557; 2805276 AB - Isolated, isovolumic rat hearts, perfused by Krebs-Henseleit buffer at constant coronary flow rate, were used to explore the hypothesis that endogenous cardiac glutathione provides protection against myocardial dysfunction associated with short periods of ischemia. Experimental animals were depleted of cardiac glutathione to 35% of control levels by intraperitoneal injections of diethylmaleate (DEM). Left ventricular pressure, coronary perfusion pressure, and glutathione levels were measured in control and experimental hearts after 60 minutes of oxygenated perfusion and after 20 minutes of global, no-flow ischemia and 30 minutes of reperfusion. With each protocol, both control and glutathione-depleted hearts received either standard buffer or one supplemented with 2 mM glutathione. Recovery of systolic function after ischemia-reperfusion was impaired in DEM-treated hearts compared with controls. In addition, the rise in perfusion pressure and chamber stiffness was also greater in DEM-treated hearts compared with controls. Recovery in glutathione-depleted hearts was improved when the reperfusate was supplemented with glutathione. In addition, the supplemented reperfusate prevented the decrease in compliance and the increase in coronary perfusion pressure in the glutathione-depleted hearts. Ischemia-reperfusion alone were not associated with a significant alteration in myocardial glutathione levels. Prewashout myocardial levels of glutathione were elevated after reperfusion with glutathione-supplemented buffer but fell to baseline levels after a short washout period. These studies demonstrate that endogenous glutathione is important in protection of myocardium from injury after ischemia-reperfusion, presumably by modifying levels of active oxygen intermediates. The smaller changes in left ventricular pressure and coronary resistance after administration of GSH probably reflects an extracellular mechanism because benefit is seen soon after reperfusion. JF - Circulation AU - Blaustein, A AU - Deneke, S M AU - Stolz, R I AU - Baxter, D AU - Healey, N AU - Fanburg, B L AD - Cardiology Section, Veterans Administration Medical Center, Cincinnati, OH 45220. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1449 EP - 1457 VL - 80 IS - 5 SN - 0009-7322, 0009-7322 KW - Free Radicals KW - 0 KW - Glutathione KW - GAN16C9B8O KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Space life sciences KW - Rats KW - Animals KW - Oxygen -- toxicity KW - Myocardial Contraction -- physiology KW - Myocardial Reperfusion Injury -- metabolism KW - Glutathione -- physiology KW - Myocardial Reperfusion Injury -- etiology KW - Myocardium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79283557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Myocardial+glutathione+depletion+impairs+recovery+after+short+periods+of+ischemia.&rft.au=Blaustein%2C+A%3BDeneke%2C+S+M%3BStolz%2C+R+I%3BBaxter%2C+D%3BHealey%2C+N%3BFanburg%2C+B+L&rft.aulast=Blaustein&rft.aufirst=A&rft.date=1989-11-01&rft.volume=80&rft.issue=5&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-18 N1 - Date created - 1989-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of iopamidol and iohexol in rat lungs following experimental aspiration. AN - 79282935; 2807806 AB - Experimental aspiration of water soluble contrast agents was performed on rats via transoral endotracheal injection. Iopamidol, iohexol and diatrizoate were the contrast agents tested. One group of rats received normal saline as a control. Adjusted lung weights were measured at 2 and 24 hours post aspiration. Radiographs were taken at 2 and 24 hours post aspiration and scored for abnormal pulmonary air space density. Diatrizoate alone demonstrated an increase in adjusted lung weights. Diatrizoate, iopamidol and iohexol showed abnormal pulmonary air space disease on radiographs at 2 hours but not at 24 hours. Histopathologic examination of rat lungs following aspiration of all three contrasts showed pulmonary vascular congestion and perivascular edema. Iopamidol showed evidence of acute cellular inflammation. Iohexol provoked a pulmonary alveolar macrophage response. JF - Investigative radiology AU - D'Agostino, H R AU - Liebig, R J AU - McGovern, M AU - Weinshelbaum, A AU - Reich, S B AD - Department of Radiology, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 899 EP - 902 VL - 24 IS - 11 SN - 0020-9996, 0020-9996 KW - Diatrizoate KW - 117-96-4 KW - Iohexol KW - 4419T9MX03 KW - Iopamidol KW - JR13W81H44 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Respiration Disorders -- pathology KW - Animals KW - Diatrizoate -- administration & dosage KW - Diatrizoate -- toxicity KW - Respiration Disorders -- chemically induced KW - Male KW - Organ Size -- drug effects KW - Inhalation KW - Iohexol -- administration & dosage KW - Respiration KW - Iopamidol -- toxicity KW - Lung -- drug effects KW - Iohexol -- toxicity KW - Lung -- pathology KW - Iopamidol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79282935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Effects+of+iopamidol+and+iohexol+in+rat+lungs+following+experimental+aspiration.&rft.au=D%27Agostino%2C+H+R%3BLiebig%2C+R+J%3BMcGovern%2C+M%3BWeinshelbaum%2C+A%3BReich%2C+S+B&rft.aulast=D%27Agostino&rft.aufirst=H&rft.date=1989-11-01&rft.volume=24&rft.issue=11&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-20 N1 - Date created - 1989-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Altered in vivo activity of liposome-incorporated lipopolysaccharide and lipid A. AN - 79281825; 2807528 AB - We compared the abilities of free and liposome-incorporated Salmonella minnesota wild-type lipopolysaccharide (LPS) and lipid A to activate peritoneal macrophages and induce lethal toxicity in mice. Incorporation of lipid A into multilamellar vesicles resulted in a 100-fold-decreased potency to prime macrophages for phorbol myristate acetate-triggered release of H2O2. In addition, liposome incorporation reduced the lethality of LPS and lipid A at least 10-fold in dactinomycin-sensitized mice. Similar results were obtained with multilamellar liposomes delivered intravenously and when small unilamellar vesicles were employed. The observed difference in toxicity was not dependent on dactinomycin treatment, since a similar decrease was obtained with large doses of liposomal LPS in unsensitized mice. Control liposomes, prepared without LPS and lipid A, did not reduce the activities of the free compounds. The administration of a sublethal amount of liposomal LPS induced within 20 days, but not during the first week, tolerance to a subsequently injected lethal dose of free endotoxin. The latter observation suggests that early-phase tolerance is not the mechanism responsible for the reduced toxicity of liposomal LPS. These data show that liposomal LPS and lipid A have reduced endotoxic activity in vivo and are consistent with our hypothesis that a direct interaction of lipid A with appropriate plasma membrane components is necessary to efficiently trigger biologic responses. This interaction, however, is prevented by the stable insertion of LPS into the liposomal membrane. JF - Infection and immunity AU - Dijkstra, J AU - Mellors, J W AU - Ryan, J L AD - Department of Medicine, Yale University School of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 3357 EP - 3363 VL - 57 IS - 11 SN - 0019-9567, 0019-9567 KW - Lipid A KW - 0 KW - Lipopolysaccharides KW - Liposomes KW - Dactinomycin KW - 1CC1JFE158 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Drug Tolerance KW - Dactinomycin -- pharmacology KW - Animals KW - Hydrogen Peroxide -- metabolism KW - Mice KW - Mice, Inbred BALB C KW - Lipid A -- toxicity KW - Lipopolysaccharides -- administration & dosage KW - Lipopolysaccharides -- immunology KW - Lipid A -- administration & dosage KW - Macrophage Activation KW - Lipopolysaccharides -- toxicity KW - Lipid A -- immunology KW - Salmonella -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79281825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Altered+in+vivo+activity+of+liposome-incorporated+lipopolysaccharide+and+lipid+A.&rft.au=Dijkstra%2C+J%3BMellors%2C+J+W%3BRyan%2C+J+L&rft.aulast=Dijkstra&rft.aufirst=J&rft.date=1989-11-01&rft.volume=57&rft.issue=11&rft.spage=3357&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-01 N1 - Date created - 1989-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Ther Drug Carrier Syst. 1987;3(2):123-93 [3542245] Am J Pathol. 1986 Aug;124(2):179-85 [3526909] J Exp Med. 1987 Mar 1;165(3):657-63 [3819645] J Immunol. 1987 Apr 15;138(8):2663-70 [3494081] Annu Rev Med. 1987;38:417-32 [3555304] Infect Immun. 1987 Jul;55(7):1622-5 [3596805] Lab Invest. 1987 Jun;56(6):583-90 [3599906] J Immunol. 1987 Sep 15;139(6):1971-7 [3040860] Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S512-6 [3317747] Proc Natl Acad Sci U S A. 1988 Jan;85(2):607-11 [3422444] J Immunol. 1988 May 1;140(9):2994-9 [3258889] J Exp Med. 1988 May 1;167(5):1708-12 [3259257] J Leukoc Biol. 1988 May;43(5):436-44 [3131472] J Clin Invest. 1988 Jun;81(6):1925-37 [3384955] J Exp Med. 1988 Jun 1;167(6):1987-92 [3290384] J Immunol. 1988 Aug 1;141(3):1006-11 [2456326] J Immunol. 1988 Aug 1;141(3):870-4 [3135314] J Exp Med. 1988 Jul 1;168(1):95-105 [3294337] Infect Immun. 1988 Oct;56(10):2650-7 [3262089] J Biol Chem. 1988 Oct 15;263(29):14802-7 [3170565] J Immunol Methods. 1988 Nov 10;114(1-2):197-205 [3263442] J Immunol. 1986 Sep 1;137(5):1681-7 [3745916] Science. 1986 Oct 24;234(4775):470-4 [3764421] J Immunol. 1989 Apr 1;142(7):2469-74 [2926140] J Exp Med. 1989 Mar 1;169(3):823-32 [2647895] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] J Exp Med. 1964 Nov 1;120:721-32 [14247715] Toxicon. 1972 Aug;10(5):491-500 [4561080] Eur J Biochem. 1972 Dec 4;31(2):230-3 [4567119] Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 [1103152] J Exp Med. 1978 Jul 1;148(1):115-27 [209122] J Exp Med. 1980 Jan 1;151(1):101-14 [7350246] Proc Natl Acad Sci U S A. 1979 Nov;76(11):5939-43 [293694] Adv Immunol. 1979;28:293-450 [396770] Infect Immun. 1980 Nov;30(2):523-30 [7002801] J Immunol Methods. 1980;38(1-2):161-70 [6778929] Biochim Biophys Acta. 1981 Apr 17;674(1):10-8 [7236723] Rev Infect Dis. 1984 Jan-Feb;6(1):51-95 [6369481] J Immunol. 1985 Mar;134(3):1619-22 [3918107] Infect Immun. 1985 Jun;48(3):658-63 [2581898] Science. 1985 Aug 30;229(4716):869-71 [3895437] Infect Immun. 1986 Mar;51(3):891-5 [3949385] J Immunol. 1986 Apr 1;136(7):2486-91 [3485151] Science. 1986 May 23;232(4753):977-80 [3754653] J Immunol. 1986 Jun 15;136(12):4525-30 [3086435] Cell. 1987 Feb 27;48(4):671-9 [3102073] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Esmolol in the management of epinephrine- and cocaine-induced cardiovascular toxicity. AN - 79260720; 2572185 JF - Anesthesia and analgesia AU - Pollan, S AU - Tadjziechy, M AD - University of Pittsburgh, Veterans Administration Medical Center, Pennsylvania 15240. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 663 EP - 664 VL - 69 IS - 5 SN - 0003-2999, 0003-2999 KW - Adrenergic beta-Antagonists KW - 0 KW - Propanolamines KW - Cocaine KW - I5Y540LHVR KW - esmolol KW - MDY902UXSR KW - Epinephrine KW - YKH834O4BH KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Nasal Polyps -- surgery KW - Male KW - Propanolamines -- therapeutic use KW - Epinephrine -- adverse effects KW - Cardiovascular Diseases -- drug therapy KW - Cardiovascular Diseases -- chemically induced KW - Cocaine -- therapeutic use KW - Epinephrine -- therapeutic use KW - Cocaine -- adverse effects KW - Adrenergic beta-Antagonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79260720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Esmolol+in+the+management+of+epinephrine-+and+cocaine-induced+cardiovascular+toxicity.&rft.au=Pollan%2C+S%3BTadjziechy%2C+M&rft.aulast=Pollan&rft.aufirst=S&rft.date=1989-11-01&rft.volume=69&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-22 N1 - Date created - 1989-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholic liver disease: quantitative image-guided P-31 MR spectroscopy. AN - 79255765; 2798871 AB - Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n = 10), alcoholic cirrhosis (n = 9), and viral hepatitis B (n = 3) and on healthy control subjects (n = 21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy. JF - Radiology AU - Meyerhoff, D J AU - Boska, M D AU - Thomas, A M AU - Weiner, M W AD - Magnetic Resonance Unit, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 393 EP - 400 VL - 173 IS - 2 SN - 0033-8419, 0033-8419 KW - Organophosphates KW - 0 KW - Phosphates KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Abridged Index Medicus KW - Index Medicus KW - Aged, 80 and over KW - Hydrogen-Ion Concentration KW - Humans KW - Hepatitis B -- metabolism KW - Adult KW - Adenosine Triphosphate -- analysis KW - Aged KW - Middle Aged KW - Organophosphates -- analysis KW - Phosphates -- analysis KW - Male KW - Liver -- analysis KW - Hepatitis B -- diagnosis KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Magnetic Resonance Spectroscopy -- methods KW - Hepatitis, Alcoholic -- diagnosis KW - Hepatitis, Alcoholic -- metabolism KW - Liver Cirrhosis, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79255765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Alcoholic+liver+disease%3A+quantitative+image-guided+P-31+MR+spectroscopy.&rft.au=Meyerhoff%2C+D+J%3BBoska%2C+M+D%3BThomas%2C+A+M%3BWeiner%2C+M+W&rft.aulast=Meyerhoff&rft.aufirst=D&rft.date=1989-11-01&rft.volume=173&rft.issue=2&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-14 N1 - Date created - 1989-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Radiology 1990 Aug;176(2):584 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gastric origin of the first-pass metabolism of ethanol in humans: effect of gastrectomy. AN - 79230769; 2792658 AB - The areas under the curve (AUCs) of blood ethanol concentrations are much smaller after oral than after intravenous administration of a small dose of ethanol. To study whether this difference is due to ethanol oxidation in the stomach, in the small intestine, or during first pass through the liver, we compared the AUCs after random administration of the same ethanol dose by the intravenous, oral, and intraduodenal routes to 5 abstaining alcoholics and via the two former routes to 10 subjects with Billroth II subtotal gastrectomy. In the nonoperated subjects, the AUCs after an ethanol dose (0.15 g/kg) given orally were 17% (p less than 0.01) of those achieved intravenously, in spite of the fact that greater than 99% of the dose had disappeared from the stomach at the completion of the AUC. By contrast, the AUCs after intraduodenal administration did not differ from those produced intravenously, indicating that neither the intestine nor the liver make a detectable contribution to this first-pass metabolism. Moreover, gastrectomy completely abolished the first-pass metabolism of ethanol. Gastric metabolism decreases the bioavailability of the ingested alcohol and thus attenuates its systemic toxicity. The abolition of this "protective barrier" in gastrectomized patients may increase their vulnerability to ethanol. JF - Gastroenterology AU - Caballeria, J AU - Frezza, M AU - Hernández-Muñoz, R AU - DiPadova, C AU - Korsten, M A AU - Baraona, E AU - Lieber, C S AD - Section of Liver Disease and Nutrition, Bronx Veterans Administration Medical Center, New York. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 1205 EP - 1209 VL - 97 IS - 5 SN - 0016-5085, 0016-5085 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Oxidation-Reduction KW - Humans KW - Liver -- metabolism KW - Intestines -- metabolism KW - Male KW - Ethanol -- blood KW - Ethanol -- pharmacokinetics KW - Stomach -- metabolism KW - Ethanol -- administration & dosage KW - Gastrectomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79230769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Gastric+origin+of+the+first-pass+metabolism+of+ethanol+in+humans%3A+effect+of+gastrectomy.&rft.au=Caballeria%2C+J%3BFrezza%2C+M%3BHern%C3%A1ndez-Mu%C3%B1oz%2C+R%3BDiPadova%2C+C%3BKorsten%2C+M+A%3BBaraona%2C+E%3BLieber%2C+C+S&rft.aulast=Caballeria&rft.aufirst=J&rft.date=1989-11-01&rft.volume=97&rft.issue=5&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-15 N1 - Date created - 1989-11-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Chemoprevention of mouse colon tumors with difluoromethylornithine during and after carcinogen treatment. AN - 79221861; 2507137 AB - alpha-Difluoromethylornithine (DFMO) treatment has been shown to modify carcinogenesis in many experimental tumor models, including skin, breast, and colon. This study was designed to determine whether DFMO treatment can inhibit experimental mouse colon tumors after carcinogen treatment and whether an associated effect of DFMO on cell proliferation in colon mucosa occurs. Male CD1 mice (40 per group) received dimethylhydrazine (30 mg/kg/week x 6 weeks, s.c.) and various schedules of DFMO, 1% in drinking water: Group A, none; Group B, following dimethylhydrazine treatment; Group C, during dimethylhydrazine treatment; and Group D, continuously throughout the study. Measurements of RBC polyamine levels showed that DFMO treatment ablated putrescine levels and confirmed that a systemic biological effect was achieved. Analysis of tumor data showed a significant inhibitory effect of DFMO treatment on colon tumor (adenomas and adenocarcinomas) incidence in Groups B (24%) and D (20%) compared to control Group A (52%, P less than 0.05 A versus B, P less than 0.02 A versus D) and on squamous cell carcinomas of the anus in all groups (P less than 0.001 A versus B, P less than 0.05 A versus C, A versus D). No consistent effect of DFMO treatment on cell proliferation in colon mucosa was identified. This study supports the hypothesis that DFMO treatment alters events in the postinitiation phases of mouse colon tumorigenesis. JF - Cancer research AU - Tempero, M A AU - Nishioka, K AU - Knott, K AU - Zetterman, R K AD - Omaha Veterans Administration Medical Center, Nebraska 68105. Y1 - 1989/11/01/ PY - 1989 DA - 1989 Nov 01 SP - 5793 EP - 5797 VL - 49 IS - 21 SN - 0008-5472, 0008-5472 KW - Dimethylhydrazines KW - 0 KW - Polyamines KW - Eflornithine KW - ZQN1G5V6SR KW - Index Medicus KW - Erythrocytes -- drug effects KW - Animals KW - Reference Values KW - Mice KW - Erythrocytes -- metabolism KW - Male KW - Polyamines -- blood KW - Eflornithine -- therapeutic use KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79221861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Chemoprevention+of+mouse+colon+tumors+with+difluoromethylornithine+during+and+after+carcinogen+treatment.&rft.au=Tempero%2C+M+A%3BNishioka%2C+K%3BKnott%2C+K%3BZetterman%2C+R+K&rft.aulast=Tempero&rft.aufirst=M&rft.date=1989-11-01&rft.volume=49&rft.issue=21&rft.spage=5793&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-20 N1 - Date created - 1989-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Attenuation of azoxymethane-induced colonic mucosal ornithine decarboxylase and tyrosine kinase activity by calcium in rats. AN - 79219500; 2790802 AB - Two in vivo and one in vitro studies were performed to evaluate the chemoprotective role of calcium during the early period of azoxymethane (AOM) induction. In the first set of experiments, groups of male Fischer 344 rats were s.c. injected with either AOM (20 mg/kg) or water (controls) and sacrificed immediately (0 time), and 1, 3, 5, and 7 days postinjection. In the second set of experiments, animals were injected with the same dose of AOM and subsequently pair-fed with rat chow containing either calcium carbonate or diet devoid of added calcium. The amount of calcium consumed was calculated to be 250 mg/kg b.w. In both experiments, colonic mucosa was assayed for ornithine decarboxylase (ODC). In addition, tyrosine kinase (Tyr-k) activity as well as tyrosine specific phosphorylation of membrane proteins were determined. Results revealed that maximal stimulation by AOM of ODC and Tyr-k activity occurred 5 days postinjection. This stimulation was significantly suppressed by calcium. AOM also produced an increase in the rate of tyrosine specific phosphorylation of two distinct colonic mucosal membrane proteins with Mr of 57,000 and 59,000. Again, dietary calcium suppressed the stimulation. In the third set of experiments, organ culture was utilized. Methylazoxymethanol, the active metabolite of AOM, was used instead of AOM in this part of the study. Four hour exposure of mucosal explants to methylazoxymethanol (1 microgram/ml) resulted in a significant (20-30%) increase in ODC and Tyr-k activity when compared to controls. Addition of either CaCl2 (2 mumol/ml) or difluoromethylornithine (2 nmol/ml) the irreversible inhibitor of ODC, significantly suppressed the methylazoxymethanol-induced activity of both ODC and Tyr-k. We conclude that calcium may have a chemoprotective role and tyrosine kinases may have a regulatory role in the early stages of AOM induction of colon cancer. JF - Cancer research AU - Arlow, F L AU - Walczak, S M AU - Luk, G D AU - Majumdar, A P AD - Veterans Administration Medical Center, Allen Park, Michigan 48101. Y1 - 1989/11/01/ PY - 1989 DA - 1989 Nov 01 SP - 5884 EP - 5888 VL - 49 IS - 21 SN - 0008-5472, 0008-5472 KW - Azo Compounds KW - 0 KW - Phosphoproteins KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Azoxymethane KW - MO0N1J0SEN KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Phosphorylation KW - Enzyme Induction -- drug effects KW - Electrophoresis, Polyacrylamide Gel KW - Colon -- enzymology KW - Kinetics KW - Phosphoproteins -- isolation & purification KW - Organ Culture Techniques KW - Male KW - Intestinal Mucosa -- enzymology KW - Azoxymethane -- pharmacology KW - Azo Compounds -- pharmacology KW - Protein-Tyrosine Kinases -- biosynthesis KW - Calcium -- pharmacology KW - Ornithine Decarboxylase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79219500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Attenuation+of+azoxymethane-induced+colonic+mucosal+ornithine+decarboxylase+and+tyrosine+kinase+activity+by+calcium+in+rats.&rft.au=Arlow%2C+F+L%3BWalczak%2C+S+M%3BLuk%2C+G+D%3BMajumdar%2C+A+P&rft.aulast=Arlow&rft.aufirst=F&rft.date=1989-11-01&rft.volume=49&rft.issue=21&rft.spage=5884&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-20 N1 - Date created - 1989-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of rat liver transaminases by low levels of acetaldehyde and the pharmacologic effects of B6 vitamers. AN - 79331772; 2818634 AB - To better define the significance and mechanism of acetaldehyde-mediated transaminase inhibition, acetaldehyde metabolism was studied in rat liver homogenates and cytosols. When either preparation was incubated at 37 degrees with 1.5 mM acetaldehyde for 4 hr, acetaldehyde levels fell rapidly in the first 30 min and little inhibition of aspartate aminotransferase (GOT) or alanine aminotransferase (GPT) resulted. In contrast, incubation with 50 mM ethanol also resulted in a peak acetaldehyde level of 1.0 to 1.5 mM by 2 hr, but this level was then maintained for the next 2 hr and transaminases were inhibited by 20-35%. Sequential addition of low dose (125-250 microM) pulses of acetaldehyde to rat liver preparations resulted in a progressive decrease in the rate of acetaldehyde disappearance. When the pulsing schedule was adjusted accordingly to maintain acetaldehyde levels between 50 and 250 microM for 8 hr, transaminases were again inhibited by 20-40%. Finally, addition of 1-5 mM pyridoxal and pyridoxal 5'-phosphate, aldehydic B6 vitamers, to cytosols 2-4 hr after pulsing with acetaldehyde was begun, almost completely prevented further transaminase inhibition. In contrast, the non-aldehydic B6 vitamers, pyridoxine, pyridoxamine and pyridoxamine 5'-phosphate, did not affect acetaldehyde-mediated transaminase inhibition. These findings suggest that (1) prolonged exposure to low levels of acetaldehyde impairs acetaldehyde metabolism in rat liver homogenates and cytosols; (2) acetaldehyde toxicity may be more dependent on sustained exposure to acetaldehyde than on the peak level of acetaldehyde attained; and (3) aldehydic B6 vitamers can modify on-going acetaldehyde-mediated transaminase inhibition. JF - Biochemical pharmacology AU - Crouch, J Y AU - Solomon, L R AD - Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1989/10/15/ PY - 1989 DA - 1989 Oct 15 SP - 3431 EP - 3437 VL - 38 IS - 20 SN - 0006-2952, 0006-2952 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Pyridoxine KW - KV2JZ1BI6Z KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Alanine Transaminase -- antagonists & inhibitors KW - Liver -- enzymology KW - Aspartate Aminotransferases -- antagonists & inhibitors KW - Pyridoxine -- pharmacology KW - Acetaldehyde -- pharmacology KW - Acetaldehyde -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79331772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Inhibition+of+rat+liver+transaminases+by+low+levels+of+acetaldehyde+and+the+pharmacologic+effects+of+B6+vitamers.&rft.au=Crouch%2C+J+Y%3BSolomon%2C+L+R&rft.aulast=Crouch&rft.aufirst=J&rft.date=1989-10-15&rft.volume=38&rft.issue=20&rft.spage=3431&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-28 N1 - Date created - 1989-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oncologic and functional considerations of total glossectomy. AN - 85242955; pmid-2552853 AB - The efficacy of total glossectomy for advanced carcinoma of the tongue remains controversial. A retrospective chart review was undertaken to evaluate the oncologic and functional results in 17 consecutive patients who underwent this procedure. There were two patients with stage III disease, eight with stage IV disease, and seven with recurrent disease. The larynx was preserved in seven patients. One patient required a secondary laryngectomy. All patients were reconstructed immediately, 11 with a pectoralis major myocutaneous flap and 6 with free-tissue transfer. The operative mortality was 6 percent; the morbidity was 59 percent. At last follow-up, 53 percent of the patients were alive without disease, with a mean disease-free survival period of 36 months. Ninety-three percent of the patients regained swallowing and independent oral alimentation; 80 percent of those with laryngeal preservation regained intelligible speech. We have concluded that total glossectomy should be considered as a primary modality for advanced carcinoma of the tongue and not solely reserved for salvage in hopeless situations. With or without laryngectomy, excellent survival and functional results can be obtained. JF - American Journal of Surgery AU - Sultan, M R AU - Coleman, J J AD - Department of Surgery, Emory University Affiliated Hospitals, Atlanta Veterans Administration Medical Center, Georgia. PY - 1989 SP - 297 EP - 302 VL - 158 IS - 4 SN - 0002-9610, 0002-9610 KW - Tongue Neoplasms KW - Evaluation Studies KW - Carcinoma, Adenoid Cystic KW - Glossectomy KW - Laryngectomy KW - Human KW - Retrospective Studies KW - Middle Age KW - Aged KW - Neoplasm Recurrence, Local KW - Surgical Flaps KW - Carcinoma, Squamous Cell KW - Speech Intelligibility KW - Deglutition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85242955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Surgery&rft.atitle=Oncologic+and+functional+considerations+of+total+glossectomy.&rft.au=Sultan%2C+M+R%3BColeman%2C+J+J&rft.aulast=Sultan&rft.aufirst=M&rft.date=1989-10-01&rft.volume=158&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Surgery&rft.issn=00029610&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Fibrosarcoma of the mandible following supravoltage irradiation. Report of a case. AN - 85225789; pmid-2789783 AB - Supravoltage irradiation is commonly thought not to be carcinogenic. Several recent studies question this concept, as does our case report. A 50-year-old woman with stage 1 squamous carcinoma of the left side of the tongue was treated in 1973 with 73 Gy of supravoltage irradiation. Twelve years later a painful, ulcerated lesion that eventually was shown to be fibrosarcoma developed in the contralateral mandible. The fibrosarcoma in this case fulfills all criteria for diagnosing radiation-induced neoplasia and demonstrates that supravoltage irradiation, like other forms of irradiation, can cause malignancy. The occasional occurrence of sarcoma should be recalled during follow-up of patients treated with supravoltage radiation. Similarly, the possibility of radiation-induced tumors should be considered in planning treatment for younger patients with tumors that can be treated equally well by surgery or irradiation. JF - Archives of Otolaryngology--Head and Neck Surgery AU - Moloy, P J AU - Kowal, K A AU - Siegel, W M AD - Ear, Nose, and Throat Section, Veterans Administration Medical Center, Long Beach, Calif. PY - 1989 SP - 1250 EP - 1252 VL - 115 IS - 10 SN - 0886-4470, 0886-4470 KW - Tongue Neoplasms KW - Fibrosarcoma KW - Radiation Dosage KW - Humans KW - Middle Aged KW - Carcinoma, Squamous Cell KW - Female KW - Mandibular Neoplasms KW - Neoplasms, Radiation-Induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Fibrosarcoma+of+the+mandible+following+supravoltage+irradiation.+Report+of+a+case.&rft.au=Moloy%2C+P+J%3BKowal%2C+K+A%3BSiegel%2C+W+M&rft.aulast=Moloy&rft.aufirst=P&rft.date=1989-10-01&rft.volume=115&rft.issue=10&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.issn=08864470&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Clinical epidemiology of chronic constipation. AN - 85202069; pmid-2551954 AB - Using health statistics from the United States and England and Wales, we review the epidemiology of constipation and possible etiologies of this disorder as suggested by its epidemiologic distribution. The analysis revealed that constipation is one of the most common chronic digestive disorders in the United States, affecting one of every 50 people. The occurrence of constipation increased with advancing age, showing an exponential increase in prevalence after the age of 65. The age distribution of constipation was similar in both sexes, but overall constipation was three times more common in women than in men. Constipation more frequently affected nonwhites than whites, and people from families with low income or less formal education. The characteristic epidemiologic pattern of constipation suggests the influence of environmental factors. Insufficient dietary fiber is widely believed to be a major cause of constipation, yet it is difficult to devise a mechanism by which dietary fiber alone could produce the marked differences observed between gender, race, and socioeconomic status. Recent evidence suggests that disruption of neural regulation of colonic motility plays an important role in the development of chronic constipation. This loss of neural regulation may result from mechanical damage to the pelvic nerves due to childbirth or pelvic surgery, exposure to environmental toxins (e.g., organochlorine insecticides or heavy metals), or possibly exposure to an infectious agent. Other environmental factors that may play a role in the pathogenesis of chronic constipation have not yet been elucidated. Consequently, studies examining the epidemiology of chronic constipation are important for providing insight into potential environmental risk factors relevant to the etiology of this disorder. JF - Journal of Clinical Gastroenterology AU - Johanson, J F AU - Sonnenberg, A AU - Koch, T R AD - Department of Medicine, Veterans Administration Medical Center, Milwaukee, Wisconsin 53295. PY - 1989 SP - 525 EP - 536 VL - 11 IS - 5 SN - 0192-0790, 0192-0790 KW - United States KW - Gastrointestinal Motility KW - Age Factors KW - Support, U.S. Gov't, P.H.S. KW - Human KW - England KW - Wales KW - Dietary Fiber KW - Socioeconomic Factors KW - Constipation KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Male KW - Female KW - Prevalence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85202069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Clinical+epidemiology+of+chronic+constipation.&rft.au=Johanson%2C+J+F%3BSonnenberg%2C+A%3BKoch%2C+T+R&rft.aulast=Johanson&rft.aufirst=J&rft.date=1989-10-01&rft.volume=11&rft.issue=5&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Regional blood flow to the canine vocal fold at rest and during phonation. AN - 85181311; pmid-2802462 AB - Recent reports have suggested that blood flow to the vocal fold decreases during phonation. However, these studies relied on indirect measures of blood flow, such as tissue oxygen tension. Among the differing methods of measuring blood flow, one of the most sensitive is the microsphere surface technique. This technique has been effective in assessing the overall and regional blood flow to a number of different organs, including the cochlea. Employing an in vivo canine model, we injected microspheres into the left atrium. From there, they were distributed and became entrapped in the tissues in proportion to blood flow. We measured the blood flow to the entire vocal fold, as well as the lamina propria and muscularis layers. The results revealed a statistically significant (p less than .002) increase in blood flow on phonation. The increase, however, was due to increased flow to the muscularis layer. The flow to the lamina propria remained unchanged during phonation. JF - The Annals of Otology, Rhinology, and Laryngology AU - Arnstein, D P AU - Berke, G S AU - Trapp, T K AU - Natividad, M AD - Division of Head and Neck Surgery, Veterans Administration Medical Center, West Los Angeles, CA. PY - 1989 SP - 796 EP - 802 VL - 98 IS - 10 SN - 0003-4894, 0003-4894 KW - Animals KW - Reference Values KW - Vocal Cords KW - Voice KW - Research Support, U.S. Gov't, Non-P.H.S. KW - Dogs KW - Male KW - Phonation KW - Regional Blood Flow UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85181311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Regional+blood+flow+to+the+canine+vocal+fold+at+rest+and+during+phonation.&rft.au=Arnstein%2C+D+P%3BBerke%2C+G+S%3BTrapp%2C+T+K%3BNatividad%2C+M&rft.aulast=Arnstein&rft.aufirst=D&rft.date=1989-10-01&rft.volume=98&rft.issue=10&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A comparison of three HA-1 couplers. AN - 85142344; pmid-2792587 AB - The use of 2-cm3 couplers for measuring the output of an ER-3A earphone has been recommended. The purpose of this study was to compare the acoustic output of three commonly available couplers and to study the intra- and inter-examiner reliability with which those measurements may be performed. While the repeatability of measurements, at least for clinical purposes, was good even for hand-held coupling of the earphone to the couplers, differences between couplers were observed. These differences were influenced by the positioning of the sound-outlet orifice relative to the interior, top wall of the couplers' cavities. A recommendation for 2-cm3 coupler calibration of the ER-3A earphone using a commonly available adapter was made. JF - Ear and Hearing AU - Larson, V D AU - Cooper, W A AD - Audiology Research Program (151), Veterans Administration Medical Center, Augusta, Georgia. PY - 1989 SP - 330 EP - 334 VL - 10 IS - 5 SN - 0196-0202, 0196-0202 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85142344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+Hearing&rft.atitle=A+comparison+of+three+HA-1+couplers.&rft.au=Larson%2C+V+D%3BCooper%2C+W+A&rft.aulast=Larson&rft.aufirst=V&rft.date=1989-10-01&rft.volume=10&rft.issue=5&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Ear+and+Hearing&rft.issn=01960202&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of CV 205-502 in hyperprolactinaemic patients intolerant of bromocriptine. AN - 79486093; 2576397 AB - CV 205-502 (Sandoz), an octahydrobenzol [g]quinoline, is a long-acting dopamine agonist which inhibits prolactin secretion. We conducted a phase 2 clinical study in 10 hyperprolactinaemic women (nine of whom were previously intolerant of bromocriptine) in order to determine (1) the dose at which CV 205-502 exerted its prolactin-lowering effect; (2) the nature of adverse reactions associated with long-term therapy; and (3) whether patients who were intolerant of bromocriptine could tolerate CV 205-502. At first patients were randomized to take initial doses of either 0.02 or 0.05 mg daily at bedtime. Thereafter these doses of medication were gradually increased either to the point of normalizing serum prolactin (to 0.70 IU/l or 20 ng/ml) or to a maximum dose of 0.14 mg daily. The lower initial dose was ineffective and had to be increased in all patients. The higher initial dose (0.05 mg) normalized prolactin in three of five women within 24 h. During chronic administration of the final dose of CV 205-502 (mean 0.09 mg a day), serum prolactin decreased from a mean level of 9.19 +/- 4.9 (SEM) IU/l to a mean level of 1.55 +/- 0.49 IU/l (n = 10 patients). Prolactin was normalized in five patients. Two patients, one of whom had been previously unresponsive to bromocriptine, and another unresponsive to pergolide with regard to prolactin inhibition, were also unresponsive to CV 205-502. Nausea, the side-effect responsible for these patients' previous intolerance of bromocriptine, occurred in six of 10 patients taking CV 205-502 but was much less disabling and did not cause any of the patients to stop this medication. Only one patient taking CV 205-502 discontinued treatment because of adverse effects (light-headedness). JF - Clinical endocrinology AU - Newman, C B AU - Hurley, A M AU - Kleinberg, D L AD - Department of Medicine, Veterans Administration Medical Center, New York 10010. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 391 EP - 400 VL - 31 IS - 4 SN - 0300-0664, 0300-0664 KW - Aminoquinolines KW - 0 KW - Dopamine Agents KW - Bromocriptine KW - 3A64E3G5ZO KW - quinagolide KW - 80Q9QWN15M KW - Prolactin KW - 9002-62-4 KW - Index Medicus KW - Drug Tolerance KW - Drug Evaluation KW - Prolactin -- blood KW - Menstruation Disturbances -- drug therapy KW - Humans KW - Adult KW - Middle Aged KW - Female KW - Aminoquinolines -- administration & dosage KW - Aminoquinolines -- adverse effects KW - Aminoquinolines -- therapeutic use KW - Hyperprolactinemia -- blood KW - Bromocriptine -- therapeutic use KW - Hyperprolactinemia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79486093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+endocrinology&rft.atitle=Effect+of+CV+205-502+in+hyperprolactinaemic+patients+intolerant+of+bromocriptine.&rft.au=Newman%2C+C+B%3BHurley%2C+A+M%3BKleinberg%2C+D+L&rft.aulast=Newman&rft.aufirst=C&rft.date=1989-10-01&rft.volume=31&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Clinical+endocrinology&rft.issn=03000664&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of neoplastic growth by N-homocysteine thiolactonyl retinamido cobalamin. AN - 79448501; 2616893 AB - Because of the importance of homocysteine thiolactone metabolism in the growth of normal tissues, and because of abnormal metabolism of homocysteine thiolactone in malignant cells, N-substituted derivatives of homocysteine thiolactone were synthesized and assayed for antineoplastic and anticarcinogenic activities. A single dose of 2.5 mg/kg of the synthetic derivative, N-homocysteine thiolactonyl retinamido cobalamin, injected directly into subcutaneous human pancreatic adenocarcinoma neoplasms in athymic mice, caused 50% inhibition of growth without evidence of toxicity. The findings suggest a novel approach to counteracting the growth of malignant neoplasms and support the hypothesis of a deficiency of an N-homocysteine thiolactonyl derivative in malignant cells. JF - Research communications in chemical pathology and pharmacology AU - McCully, K S AU - Tzanakakis, G N AU - Vezeridis, M P AD - Veterans Administration Medical Center, Providence RI 02908. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 117 EP - 122 VL - 66 IS - 1 SN - 0034-5164, 0034-5164 KW - Antineoplastic Agents KW - 0 KW - N-homocysteine thiolactonyl retinamido cobalamin KW - Homocysteine KW - 0LVT1QZ0BA KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured -- drug effects KW - Pancreatic Neoplasms KW - Humans KW - Cell Division -- drug effects KW - Mice, Nude KW - Mice KW - Adenocarcinoma KW - Male KW - Vitamin B 12 -- analogs & derivatives KW - Vitamin B 12 -- pharmacology KW - Homocysteine -- pharmacology KW - Neoplasms, Experimental -- drug therapy KW - Neoplasms, Experimental -- pathology KW - Homocysteine -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79448501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Inhibition+of+neoplastic+growth+by+N-homocysteine+thiolactonyl+retinamido+cobalamin.&rft.au=McCully%2C+K+S%3BTzanakakis%2C+G+N%3BVezeridis%2C+M+P&rft.aulast=McCully&rft.aufirst=K&rft.date=1989-10-01&rft.volume=66&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-15 N1 - Date created - 1990-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glycine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label, pilot study. AN - 79433301; 2611765 AB - In an open-label study, glycine was administered orally (10.8 g/day in three divided doses) to six chronically psychotic patients, as an adjunct to conventional neuroleptic therapy, for periods extending from 4 days to 8 weeks. Glycine was administered in an effort to facilitate endogenous glutamatergic transmission at the level of the N-methyl-D-aspartate (NMDA) receptor complex, since a glutamatergic deficiency in the pathophysiology of schizophrenia has been postulated. Therapeutic efficacy was assessed with standardized psychiatric rating scales. Beneficial effects on behavioral symptomatology were observed in two patients, whereas two others worsened. In one of the two responders, clinical deterioration occurred after glycine withdrawal consistent with a positive adjuvant effect in this patient. However, glycine rechallenge in this patient was not associated with the clinical improvement seen during the initial glycine period. Clinical worsening was not observed after glycine discontinuation in the second responder. Glycine administration reduced neuroleptic-induced muscle stiffness and extrapyramidal dysfunction in three of the six patients. All patients tolerated the clinical trial. The limited penetrability of glycine across the blood-brain barrier is a major limitation of this approach to facilitating glutamatergic transmission at the level of the NMDA receptor complex. JF - Clinical neuropharmacology AU - Rosse, R B AU - Theut, S K AU - Banay-Schwartz, M AU - Leighton, M AU - Scarcella, E AU - Cohen, C G AU - Deutsch, S I AD - Psychiatry Service, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 416 EP - 424 VL - 12 IS - 5 SN - 0362-5664, 0362-5664 KW - Adjuvants, Pharmaceutic KW - 0 KW - Vitamin E KW - 1406-18-4 KW - Benztropine KW - 1NHL2J4X8K KW - Thiothixene KW - 7318FJ13YJ KW - Haloperidol KW - J6292F8L3D KW - Loxapine KW - LER583670J KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Haloperidol -- adverse effects KW - Loxapine -- adverse effects KW - Haloperidol -- therapeutic use KW - Humans KW - Aged KW - Pilot Projects KW - Drug Therapy, Combination KW - Thiothixene -- therapeutic use KW - Thiothixene -- adverse effects KW - Adult KW - Benztropine -- therapeutic use KW - Chronic Disease KW - Loxapine -- therapeutic use KW - Vitamin E -- administration & dosage KW - Male KW - Cognition -- drug effects KW - Glycine -- pharmacology KW - Basal Ganglia Diseases -- drug therapy KW - Glycine -- therapeutic use KW - Schizophrenia -- drug therapy KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79433301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neuropharmacology&rft.atitle=Glycine+adjuvant+therapy+to+conventional+neuroleptic+treatment+in+schizophrenia%3A+an+open-label%2C+pilot+study.&rft.au=Rosse%2C+R+B%3BTheut%2C+S+K%3BBanay-Schwartz%2C+M%3BLeighton%2C+M%3BScarcella%2C+E%3BCohen%2C+C+G%3BDeutsch%2C+S+I&rft.aulast=Rosse&rft.aufirst=R&rft.date=1989-10-01&rft.volume=12&rft.issue=5&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Clinical+neuropharmacology&rft.issn=03625664&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-13 N1 - Date created - 1990-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hematological complications of alcoholism. AN - 79376615; 2688472 AB - Numerous clinical observations support the notion that ethanol has multiple pathologic effects on hematopoietic tissue. The effects of alcohol on blood are diverse. The long-term ingestion of large quantities of ethanol has been shown to alter a substantial number of physiologic and biochemical variables. Abnormalities involving leukocytes, platelets, and erythrocytes may occur singly or in various combinations. Due to the frequent concomitant presence of alcohol-related hepatic disease, nutritional deficiencies, infection, and other chronic diseases, it is often difficult to distinguish the specific hematologic toxicities of alcohol ingestion from the hematologic toxicities of associated morbid conditions. Depressed hematopoietic cell formation (Table 2), increased destruction, and alterations in morphology and function of hematopoietic cells have been described. JF - Alcoholism, clinical and experimental research AU - Ballard, H S AD - Veterans' Administration Hospital, Department of Medicine, New York, New York. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 706 EP - 720 VL - 13 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Erythrocytes -- drug effects KW - Humans KW - Blood Platelets -- drug effects KW - Bone Marrow -- drug effects KW - Leukocytes -- drug effects KW - Hematologic Diseases -- blood KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79376615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Hematological+complications+of+alcoholism.&rft.au=Ballard%2C+H+S&rft.aulast=Ballard&rft.aufirst=H&rft.date=1989-10-01&rft.volume=13&rft.issue=5&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the increased binding of acetaldehyde to red blood cells in alcoholics. AN - 79376561; 2688464 AB - Using equilibrium dialysis, we found that acetaldehyde, at the levels commonly occurring after ethanol ingestion, did not bind detectably to plasma proteins, but there was significant binding to red blood cells, more in alcoholics than in nonalcoholics. The binding to red blood cells was inhibited by pyridoxal phosphate and N-ethylmaleimide, suggesting adduction to amino and thiol groups. Binding kinetics were consistent with at least two sites. The one with the highest affinity for acetaldehyde corresponded to hemoglobin. Its affinity and Bmax were not changed in alcoholics, but these binding sites accounted for only 44% of the sites available in the red blood cells of alcoholics and 80% of those in controls. Moreover, this binding was not inhibited by N-ethylmaleimide. There was no detectable binding to red cell ghosts. Nonprotein binding was then assessed by changes in NADH produced by the addition of protein-free fractions of the cells to an alcohol dehydrogenase system in equilibrium; this revealed a second binder of lower affinity, larger capacity and with sensitivity to both inhibitors. This binding (possibly due to thiazolidine formation with cysteine) was enhanced in alcoholics, whose red blood cell cysteine content was doubled. Levels of red blood cell cysteine and acetaldehyde remained high for 2 weeks after withdrawal. Because of the prolonged persistence after withdrawal, these changes may provide new markers of alcoholism. JF - Alcoholism, clinical and experimental research AU - Hernández-Muñoz, R AU - Baraona, E AU - Blacksberg, I AU - Lieber, C S AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York, NY. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 654 EP - 659 VL - 13 IS - 5 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Ethanol -- pharmacokinetics KW - Humans KW - Binding, Competitive KW - Alcoholic Intoxication -- blood KW - Binding Sites KW - Acetaldehyde -- pharmacokinetics KW - Erythrocytes -- metabolism KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79376561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Characterization+of+the+increased+binding+of+acetaldehyde+to+red+blood+cells+in+alcoholics.&rft.au=Hern%C3%A1ndez-Mu%C3%B1oz%2C+R%3BBaraona%2C+E%3BBlacksberg%2C+I%3BLieber%2C+C+S&rft.aulast=Hern%C3%A1ndez-Mu%C3%B1oz&rft.aufirst=R&rft.date=1989-10-01&rft.volume=13&rft.issue=5&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical potential of low molecular weight heparins. AN - 79309975; 2554501 JF - Seminars in thrombosis and hemostasis AU - Messmore, H L AD - Hines Veterans Administration Hospital, IL 60141. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 405 EP - 408 VL - 15 IS - 4 SN - 0094-6176, 0094-6176 KW - Fibrinolytic Agents KW - 0 KW - Heparin, Low-Molecular-Weight KW - Protamines KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - Humans KW - Postoperative Complications -- prevention & control KW - Clinical Trials as Topic KW - Pulmonary Embolism -- drug therapy KW - Heparin -- immunology KW - Heparin -- therapeutic use KW - Renal Dialysis KW - Heparin -- adverse effects KW - Thrombocytopenia -- etiology KW - Hemorrhage -- chemically induced KW - Protamines -- pharmacology KW - Thrombophlebitis -- prevention & control KW - Cardiopulmonary Bypass KW - Thrombophlebitis -- drug therapy KW - Fibrinolytic Agents -- therapeutic use KW - Heparin, Low-Molecular-Weight -- adverse effects KW - Heparin, Low-Molecular-Weight -- therapeutic use KW - Heparin, Low-Molecular-Weight -- antagonists & inhibitors KW - Fibrinolytic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79309975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+thrombosis+and+hemostasis&rft.atitle=Clinical+potential+of+low+molecular+weight+heparins.&rft.au=Messmore%2C+H+L&rft.aulast=Messmore&rft.aufirst=H&rft.date=1989-10-01&rft.volume=15&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Seminars+in+thrombosis+and+hemostasis&rft.issn=00946176&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increases in Na+,K+-ATPase activity of erythrocytes and skeletal muscle after chronic ethanol consumption: evidence for reduced efficiency of the enzyme. AN - 79304349; 2554292 AB - Increased Na+,K+-ATPase activity observed after chronic ethanol consumption has been examined to determine whether the increase is due to changes in the kinetic properties of the enzyme or increases in the amount of enzyme in the membranes examined. In skeletal muscle and erythrocyte ghosts from rat, as well as from humans, increased Na+,K+-ATPase activity in ethanol-consuming individuals was not accompanied by an increase in the number of ouabain binding sites. In studies with intact human erythrocytes, similar ouabain-sensitive 22Na+ and 86Rb+ pumping rates were observed between normal and ethanol-consuming individuals and the Na+ to Rb+ pumping ratio was found to be 1.5 in all cases. However, ouabain-sensitive lactate plus Pi formation was increased in cells from alcoholic individuals. Thus these data suggest that increased enzyme activity may be due to a kinetic alteration of the Na+,K+-ATPase and that the enzyme may be less efficient in coupling ion pumping to ATP hydrolysis than the enzyme in normal cells. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Johnson, J H AU - Crider, B P AD - Veterans Administration Medical Center, Dallas, TX 75216. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 7857 EP - 7860 VL - 86 IS - 20 SN - 0027-8424, 0027-8424 KW - Ouabain KW - 5ACL011P69 KW - Sodium KW - 9NEZ333N27 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Rubidium KW - MLT4718TJW KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Kinetics KW - Humans KW - Adult KW - Rubidium -- blood KW - Erythrocyte Membrane -- enzymology KW - Sodium -- blood KW - Ouabain -- pharmacology KW - Male KW - Erythrocytes -- enzymology KW - Alcoholism -- enzymology KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Sodium-Potassium-Exchanging ATPase -- blood KW - Muscles -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79304349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Increases+in+Na%2B%2CK%2B-ATPase+activity+of+erythrocytes+and+skeletal+muscle+after+chronic+ethanol+consumption%3A+evidence+for+reduced+efficiency+of+the+enzyme.&rft.au=Johnson%2C+J+H%3BCrider%2C+B+P&rft.aulast=Johnson&rft.aufirst=J&rft.date=1989-10-01&rft.volume=86&rft.issue=20&rft.spage=7857&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-01 N1 - Date created - 1989-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1966 Jun 9;274(23):1277-85 [5936410] J Clin Invest. 1989 Jul;84(1):347-51 [2544628] Acta Biol Med Ger. 1973;30(2):223-9 [4723712] Methods Enzymol. 1974;31:172-80 [4370662] J Pharmacol Exp Ther. 1975 Mar;192(3):575-82 [123585] Anal Biochem. 1976 May 7;72:57-65 [942077] Eur J Biochem. 1978 May 16;86(2):581-7 [149006] Arch Gen Psychiatry. 1978 Jul;35(7):837-44 [678037] Eur J Pharmacol. 1979 Jul 1;56(4):297-304 [225178] Biochemistry. 1980 Aug 5;19(16):3836-40 [7407072] Am J Physiol. 1984 May;246(5 Pt 2):F700-9 [6232859] J Pharmacol Exp Ther. 1985 Feb;232(2):475-9 [2982012] Am J Med Sci. 1985 Jan;289(1):22-6 [2578734] Am J Physiol. 1986 Aug;251(2 Pt 2):F313-8 [3017125] Alcohol Clin Exp Res. 1986 Oct;10(5):526-30 [3026197] J Pharmacol Exp Ther. 1970 Aug;174(2):330-6 [4247519] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal injury in DOCA-salt hypertensive C5-sufficient and C5-deficient mice. AN - 79295786; 2681931 AB - We induced hypertension by uninephrectomy and treatment with desoxycorticosterone (DOCA) and 1% NaCl in the drinking water in congenic mice that differ in the single gene locus responsible for the presence or absence of the complement component C5 and compared them to uninephrectomized normotensive (no DOCA-NaCl) mice. In contrast to C5-sufficient (C5S) mice. C5-deficient (C5D) mice can neither generate C5a nor assemble C5b-9. After four weeks of treatment, DOCA-C5S and -C5D mice developed similar degrees of hypertension; mice receiving no DOCA remained normotensive. Only hypertensive mice developed glomerular injury. Hypertensive DOCA-C5D mice developed more glomerular capillary loop dilatation and larger glomerular capillary tuft volumes than DOCA-C5S mice (1.0 +/- 0.1 vs. 0.7 +/- 0.03 X 10(6) microns 3, respectively, P less than 0.05). However, DOCA-C5S mice, compared to DOCA-C5D mice, had significantly more glomerular cell proliferation (64.5 +/- 2 vs. 42 +/- 3 nuclei/glomerulus), cell necrosis (injury score 22 +/- 1 vs. 17 +/- 1), extracapillary proliferation (26 +/- 4 vs. 2.5 +/- 2% of glomeruli) and proteinuria (5.9 +/- 0.8 vs. 3.7 +/- 0.5 mg/24 hr; all P less than 0.05). By immunofluorescence microscopy both DOCA-C5S and -C5D had mesangial C3 deposits but only DOCA-C5S mice had C9 deposits. After 16 weeks of DOCA-NaCl C5S mice, in comparison to C5D mice, had more severe glomerulosclerosis (injury score 50 +/- 6 vs. 12 +/- 4), proteinuria (16.6 +/- 0.1 vs. 9 +/- 0.1 mg/24 hr), and renal insufficiency (serum creatinine 0.25 vs. 0.15 mg/dl), all P less than 0.05. These changes occurred despite levels of hypertension that were similar in DOCA-NaCl C5S and C5D throughout the whole study period. We conclude that C5a and/or C5b-9 may play an important role in hypertensive glomerular injury. Moreover, these studies demonstrate that differences in host responses may determine target organ susceptibility to similar injurious mechanisms. JF - Kidney international AU - Raij, L AU - Dalmasso, A P AU - Staley, N A AU - Fish, A J AD - Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 582 EP - 592 VL - 36 IS - 4 SN - 0085-2538, 0085-2538 KW - Complement C5 KW - 0 KW - Complement Membrane Attack Complex KW - Sodium, Dietary KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Complement C5a -- physiology KW - Animals KW - Complement Membrane Attack Complex -- physiology KW - Microscopy, Electron KW - Mice KW - Fluorescent Antibody Technique KW - Male KW - Complement C5 -- deficiency KW - Desoxycorticosterone -- toxicity KW - Sodium, Dietary -- toxicity KW - Hypertension -- pathology KW - Hypertension -- etiology KW - Complement C5 -- physiology KW - Kidney Glomerulus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79295786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Renal+injury+in+DOCA-salt+hypertensive+C5-sufficient+and+C5-deficient+mice.&rft.au=Raij%2C+L%3BDalmasso%2C+A+P%3BStaley%2C+N+A%3BFish%2C+A+J&rft.aulast=Raij&rft.aufirst=L&rft.date=1989-10-01&rft.volume=36&rft.issue=4&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pseudomonas aeruginosa infections associated with use of povidone-iodine in patients receiving continuous ambulatory peritoneal dialysis. AN - 79293699; 2509549 AB - Fifteen episodes of infection due to Pseudomonas aeruginosa, including peritonitis and catheter site infections, occurred in nine patients receiving continuous ambulatory peritoneal dialysis over a 27-month period. Eight episodes were associated with catheter loss. Occurrence of P aeruginosa infection was significantly associated with use of povidone-iodine solution to cleanse the catheter site. There was no association with use of povidone-iodine solution to disinfect tubing connections, use of other skin care products or exposure to other environmental sources of P aeruginosa. Cultures of available povidone-iodine products were negative. Local irritation and alteration in skin flora caused by antiseptic solution or low-level contamination of povidone-iodine solution are potential mechanisms of infection. JF - Infection control and hospital epidemiology AU - Goetz, A AU - Muder, R R AD - Department of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 447 EP - 450 VL - 10 IS - 10 SN - 0899-823X, 0899-823X KW - Povidone-Iodine KW - 25655-41-8 KW - Povidone KW - 9003-39-8 KW - Index Medicus KW - Nursing KW - Pseudomonas aeruginosa -- isolation & purification KW - Humans KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Catheters, Indwelling KW - Pseudomonas Infections -- epidemiology KW - Povidone-Iodine -- adverse effects KW - Peritoneal Dialysis, Continuous Ambulatory -- adverse effects KW - Kidney Failure, Chronic -- therapy KW - Pseudomonas Infections -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79293699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+and+hospital+epidemiology&rft.atitle=Pseudomonas+aeruginosa+infections+associated+with+use+of+povidone-iodine+in+patients+receiving+continuous+ambulatory+peritoneal+dialysis.&rft.au=Goetz%2C+A%3BMuder%2C+R+R&rft.aulast=Goetz&rft.aufirst=A&rft.date=1989-10-01&rft.volume=10&rft.issue=10&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Infection+control+and+hospital+epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-14 N1 - Date created - 1989-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Histopathological effects of homocysteine thiolactone on epithelial and stromal tissues. AN - 79282094; 2806470 AB - To study the effects of homocysteine on epithelial and stromal tissues, the free base of homocysteine thiolactone was synthesized and administered to mice. Intraperitoneal and intramuscular doses of 0.2 to 2.0 mg/g are acutely toxic, causing as much as 90% mortality because of intense tissue necrosis at the injection site, congestion and fibrin thrombi in pulmonary vessels, focal necrosis of liver and kidney, and deposition of lipid within hepatocytes. In survivors of intramuscular injection the area of tissue necrosis is surrounded by fibrosis, calcification, hypertrophy of nerves and ducts, and formation of acanthotic squamous epithelium with hyperkeratosis and focal dysplasia. Topical homocysteine thiolactone on skin is not systemically toxic, but ulceration, fibrosis, acute and chronic inflammation, angiogenesis, acanthosis, hyperkeratosis, and dysplastic squamous epithelium are observed. The findings show that homocysteine thiolactone promotes keratin formation by squamous epithelium, interferes with cellular processes necessary for viability, stimulates epithelial dysplasia and stromal hyperplasia, and produces intravascular fibrin thrombi. JF - Experimental and molecular pathology AU - McCully, K S AU - Vezeridis, M P AD - Veterans Administration Medical Center, Providence, Rhode Island 02908. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 159 EP - 170 VL - 51 IS - 2 SN - 0014-4800, 0014-4800 KW - Homocysteine KW - 0LVT1QZ0BA KW - homocysteine thiolactone KW - D5H88XF24X KW - Index Medicus KW - Injections, Intraperitoneal KW - Mice, Inbred A KW - Animals KW - Necrosis KW - Fibrosis KW - Injections, Intramuscular KW - Mice KW - Epithelium -- pathology KW - Blood Vessels -- pathology KW - Female KW - Epithelium -- drug effects KW - Administration, Topical KW - Liver -- pathology KW - Skin -- drug effects KW - Kidney -- pathology KW - Liver -- drug effects KW - Skin -- pathology KW - Kidney -- drug effects KW - Muscles -- pathology KW - Muscles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79282094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+molecular+pathology&rft.atitle=Histopathological+effects+of+homocysteine+thiolactone+on+epithelial+and+stromal+tissues.&rft.au=McCully%2C+K+S%3BVezeridis%2C+M+P&rft.aulast=McCully&rft.aufirst=K&rft.date=1989-10-01&rft.volume=51&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Experimental+and+molecular+pathology&rft.issn=00144800&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-15 N1 - Date created - 1989-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mucormycosis: association with deferoxamine therapy. AN - 79258605; 2679077 JF - The American journal of medicine AU - Daly, A L AU - Velazquez, L A AU - Bradley, S F AU - Kauffman, C A AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan 48105. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 468 EP - 471 VL - 87 IS - 4 SN - 0002-9343, 0002-9343 KW - Iron KW - E1UOL152H7 KW - Deferoxamine KW - J06Y7MXW4D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Drug Overdose KW - Middle Aged KW - Female KW - Iron -- poisoning KW - Deferoxamine -- adverse effects KW - Myelodysplastic Syndromes -- drug therapy KW - Deferoxamine -- therapeutic use KW - Mucormycosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79258605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Mucormycosis%3A+association+with+deferoxamine+therapy.&rft.au=Daly%2C+A+L%3BVelazquez%2C+L+A%3BBradley%2C+S+F%3BKauffman%2C+C+A&rft.aulast=Daly&rft.aufirst=A&rft.date=1989-10-01&rft.volume=87&rft.issue=4&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-03 N1 - Date created - 1989-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal failure after intravesical mitomycin C. AN - 79255410; 2508290 AB - Severe side effects, local or systemic, are uncommon with intravesically administered mitomycin C. Bladder fibrosis and contracture, with resultant renal failure, are unusual but possible. JF - Urology AU - Farha, A J AU - Krauss, D J AD - Veterans Administration Medical Center, Syracuse, New York. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 216 EP - 217 VL - 34 IS - 4 SN - 0090-4295, 0090-4295 KW - Mitomycins KW - 0 KW - Mitomycin KW - 50SG953SK6 KW - Index Medicus KW - Humans KW - Carcinoma in Situ -- drug therapy KW - Urinary Bladder Neoplasms -- drug therapy KW - Middle Aged KW - Male KW - Carcinoma, Transitional Cell -- drug therapy KW - Administration, Intravesical KW - Mitomycins -- adverse effects KW - Mitomycins -- therapeutic use KW - Acute Kidney Injury -- chemically induced KW - Mitomycins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79255410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Renal+failure+after+intravesical+mitomycin+C.&rft.au=Farha%2C+A+J%3BKrauss%2C+D+J&rft.aulast=Farha&rft.aufirst=A&rft.date=1989-10-01&rft.volume=34&rft.issue=4&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=00904295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-16 N1 - Date created - 1989-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biological retention of fission products from the Chernobyl plume. AN - 79229845; 2793482 JF - Health physics AU - Mirell, S G AU - Blahd, W H AD - Nuclear Medicine Ultrasound Service, Wadsworth Division, Veterans Administration Medical Center, West Los Angeles, CA 90073. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 649 EP - 652 VL - 57 IS - 4 SN - 0017-9078, 0017-9078 KW - Radioactive Fallout KW - 0 KW - Index Medicus KW - Half-Life KW - Humans KW - Ukraine KW - Accidents KW - Radioactive Fallout -- analysis KW - Nuclear Reactors KW - Nuclear Fission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79229845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Biological+retention+of+fission+products+from+the+Chernobyl+plume.&rft.au=Mirell%2C+S+G%3BBlahd%2C+W+H&rft.aulast=Mirell&rft.aufirst=S&rft.date=1989-10-01&rft.volume=57&rft.issue=4&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-08 N1 - Date created - 1989-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic incomplete atrioventricular block induced by radiofrequency catheter ablation. AN - 79228581; 2791253 AB - To determine if catheter ablation of the atrioventricular (AV) junction with radiofrequency energy can induce chronic incomplete (first- and second-degree) AV block to avoid the need for a permanent pacemaker, 20 closed-chest dogs were studied. Group 1 (10 dogs) received radiofrequency energy (750 kHz) with a fixed power setting (5 or 10 W) while increasing the pulse duration from 10 to 50 seconds for each application. Group 2 (10 dogs) received energy with a fixed pulse duration (20 or 30 seconds) while increasing the power setting from 5 to 10 W or from 10 to 20 W during each energy delivery. Radiofrequency energy was delivered between a chest-patch electrode and the distal electrode of a regular 7F tripolar His bundle catheter. For each application, the energy delivery was interrupted when 1) the PR interval prolonged (greater than 50%) or 2) second-degree or complete AV block occurred and persisted up to 5 seconds. The ablation procedure ended when there was 1) persistent PR prolongation (greater than 50%) or persistent second-degree AV block (lasting greater than 30 minutes) after ablation, 2) occurrence of two consecutive transient (less than 1 minute) complete AV blocks after each energy delivery, or 3) complete AV block (lasting greater than 2 minutes) after ablation. Of seven dogs in group 1 and five dogs in group 2 in which incomplete AV block was achieved 1 hour after the procedure, six in group 1 and five in group 2 remained in incomplete AV block 2-3 months after ablation. One dog in group 1 progressed into complete AV block. Of the remaining three dogs in group 1 and five dogs in group 2 in which complete AV block was initially achieved 1 hour after ablation, two in group 1 and four in group 2 continued to have complete AV block, whereas one in each group had AV conduction returned to incomplete at 1-2 months of follow-up. Thus, a total of 13 dogs had chronic incomplete AV block induced by radiofrequency catheter ablation. Pathologic examination of the conduction system in two dogs with first-degree AV block, two dogs with second-degree AV block, and one dog with complete AV block showed discrete scars involving the approaches to the AV node and the AV node itself. It is concluded that, in most dogs studied, chronic incomplete AV block could be achieved by careful titration of the dosage of radiofrequency energy and by regulation of the ablation end points. JF - Circulation AU - Huang, S K AU - Bharati, S AU - Graham, A R AU - Gorman, G AU - Lev, M AD - Department of Internal Medicine, Tucson Veterans Administration Medical Center, Arizona. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 951 EP - 961 VL - 80 IS - 4 SN - 0009-7322, 0009-7322 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myocardium -- pathology KW - Electrocardiography KW - Dogs KW - Follow-Up Studies KW - Chronic Disease KW - Time Factors KW - Male KW - Female KW - Heart Conduction System -- pathology KW - Radio Waves KW - Heart Block -- physiopathology KW - Heart Block -- etiology KW - Cardiac Catheterization KW - Radiation Injuries, Experimental KW - Heart Block -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79228581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Chronic+incomplete+atrioventricular+block+induced+by+radiofrequency+catheter+ablation.&rft.au=Huang%2C+S+K%3BBharati%2C+S%3BGraham%2C+A+R%3BGorman%2C+G%3BLev%2C+M&rft.aulast=Huang&rft.aufirst=S&rft.date=1989-10-01&rft.volume=80&rft.issue=4&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-15 N1 - Date created - 1989-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pancreatic transplant rejection: assessment with duplex US. AN - 79211143; 2675179 AB - The value of duplex ultrasonography (US) in the assessment of pancreatic transplants was studied in 22 patients over a 1 1/2-year period. Ninety-eight duplex US examinations were performed, and the Doppler arterial resistive indexes (RIs) correlated with clinical events after transplantation. The RI was 0.70 or less in the parenchymal vessels in all instances of normal transplant function and greater than 0.70 in seven of eight clinical episodes of rejection (87.5%). In all studies performed during these eight cases of rejection, the positive predictive value of an RI exceeding 0.70 was 100%. The negative predictive value of an RI of less than 0.70 in excluding rejection was 90%. High RI values were not found in isolated episodes of cyclosporine toxicity, pancreatitis, peripancreatic hemorrhage, or infection. Duplex US may prove to be more accurate in the diagnosis of rejection of pancreatic transplants versus renal transplants because the former cases have fewer causes of increased vascular impedance and diminished perfusion. JF - Radiology AU - Patel, B AU - Wolverson, M K AU - Mahanta, B AD - John Cochran Veterans Administration Hospital, St Louis., MO. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 131 EP - 135 VL - 173 IS - 1 SN - 0033-8419, 0033-8419 KW - Abridged Index Medicus KW - Index Medicus KW - Vascular Resistance KW - Pancreas -- blood supply KW - Humans KW - Splenic Artery -- physiopathology KW - Male KW - Female KW - Pancreas Transplantation KW - Graft Rejection KW - Ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79211143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Pancreatic+transplant+rejection%3A+assessment+with+duplex+US.&rft.au=Patel%2C+B%3BWolverson%2C+M+K%3BMahanta%2C+B&rft.aulast=Patel&rft.aufirst=B&rft.date=1989-10-01&rft.volume=173&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-18 N1 - Date created - 1989-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. AN - 79203041; 2673969 AB - Perivenular hepatocytes are the first cells within the liver lobule to display signs of toxicity following long-term alcohol use. In an attempt to explain this phenomenon, we have examined the hepatic intralobular distribution in rats and man of P450IIE1, a P-450 isozyme that not only oxidizes ethanol but is also inducible by this agent. Frozen liver sections and microsomes were prepared from male Sprague-Dawley rats pair-fed liquid diets containing 36% of total calories as either ethanol or carbohydrate (control) for 10 to 21 days. Frozen sections or microsomes were also prepared from liver biopsy samples obtained from 17 male patients with diverse drinking histories. Immunohistochemical staining was performed using the peroxidase-antiperoxidase method after liver sections were reacted with monospecific antibody (IgG) directed against human P450IIE1. Immunoreaction intensity was blindly rated in order to provide a semiquantitative assessment of P450IIE1 levels in perivenular, midzonal and periportal hepatocytes. At low applied anti-P450IIE1 IgG concentrations (2.5 micrograms per ml), P450IIE1 immunostaining was observed exclusively within the perivenular area in sections from all ethanol-treated rats, whereas no visible immunoreaction was found in sections from their pair-fed controls. At higher applied antibody concentrations (15 micrograms per ml), panlobular antigen immunostaining was observed in five of the six ethanol-treated animals, and P450IIE1 could now also be detected in perivenular hepatocytes from the control rats. In accordance with these immunohistochemical findings, protein blotting with anti-P450IIE1 IgG revealed a 7.5-fold increase in liver microsomal P450IIE1 content in ethanol-treated animals when compared to their pair-fed controls. With human liver, perivenular P450IIE1 immunostaining was observed only in biopsy sections obtained from recently drinking alcoholics (abstinence period of 1 day) when limiting concentrations (5 micrograms per ml) of the primary antibody were used. Increasing the applied anti-P450IIE1 IgG concentration to 15 micrograms per ml resulted in perivenular staining of the immunogen in liver sections from abstinent alcoholics (abstinence period of 4 to 8 days) and nondrinkers as well. Immunoblot analysis of human liver microsomes disclosed that the hepatic microsomal P450IIE1 content in recently drinking alcoholics was 4-fold higher than that found in nondrinkers. Our results show that, in both rats and in man, P450IIE1 is normally localized within the perivenular region, or zone 3, of the liver lobule, and that induction of P450IIE1 by prolonged alcohol consumption occurs primarily within the same acinar regi JF - Hepatology (Baltimore, Md.) AU - Tsutsumi, M AU - Lasker, J M AU - Shimizu, M AU - Rosman, A S AU - Lieber, C S AD - Section of Liver Disease, Bronx Veterans Administration Medical Center, New York 10468. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 437 EP - 446 VL - 10 IS - 4 SN - 0270-9139, 0270-9139 KW - Isoenzymes KW - 0 KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Humans KW - Aged KW - Alcohol Drinking KW - Rats, Inbred Strains KW - Rats KW - Isoenzymes -- analysis KW - Alcoholism -- enzymology KW - Enzyme Induction -- drug effects KW - Isoenzymes -- biosynthesis KW - Adult KW - Microsomes, Liver -- enzymology KW - Middle Aged KW - Immunoenzyme Techniques KW - Male KW - Cytochrome P-450 Enzyme System -- analysis KW - Liver -- anatomy & histology KW - Liver -- enzymology KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Cytochrome P-450 Enzyme System -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79203041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=The+intralobular+distribution+of+ethanol-inducible+P450IIE1+in+rat+and+human+liver.&rft.au=Tsutsumi%2C+M%3BLasker%2C+J+M%3BShimizu%2C+M%3BRosman%2C+A+S%3BLieber%2C+C+S&rft.aulast=Tsutsumi&rft.aufirst=M&rft.date=1989-10-01&rft.volume=10&rft.issue=4&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Experimental methods of ethanol administration. AN - 79201985; 2673971 AB - Techniques are reviewed for the experimental feeding of alcohol, including a liquid diet procedure invented 25 years ago. This technique results in much higher ethanol intake than with other approaches. As a consequence, various complications observed in alcoholics can be reproduced in animal models. These include fatty liver, hyperlipemia, various metabolic and endocrine disorders, tolerance to ethanol and other drugs, physical dependence and withdrawal and, in the baboon, liver fibrosis and cirrhosis. Variations of the liquid diet formulation are compared, and adequacy of nutrition in terms of minerals, vitamins, lipotropes, carbohydrates and proteins is discussed. The importance of selecting proper controls is emphasized. The respective advantages of three standardized basic rat formulas are reviewed: (i) an all-purpose (35% fat) diet, comparable to the diet previously referred to as the "Lieber-DeCarli formula" and suitable for most experimental applications, particularly those intended to mimic the clinical situation in which the various effects of alcohol occur in the setting of hepatic changes characterized by a fatty liver; (ii) a low-fat diet comparable in all respects to the preceding diet but with a lower fat content, intended to minimize the hepatic changes, and (iii) a high-protein formula particularly useful in those circumstances in which an oversupply of dietary protein might be recommended (i.e. pregnancy). Variations of this technique, including continuous intragastric infusion, are also discussed. It is concluded that, for most experimental studies of chronic alcohol consumption, the liquid diet technique provides one of the most efficient tools to study the effects of ethanol under controlled nutritional conditions because it allows for alcohol consumption of clinical relevance and offers flexibility to adjust to special experimental or physiologic needs by allowing for various substitutions required for a particular experimental design, including changes in lipids, proteins or other dietary constituents. The technique also facilitates the comparison with controls by simplifying the pair feeding and is the best procedure available for the study of the toxic effects of alcohol and their interactions with deficiency or excess of various nutrients. JF - Hepatology (Baltimore, Md.) AU - Lieber, C S AU - DeCarli, L M AU - Sorrell, M F AD - Section of Liver Disease and Nutrition, Bronx Veterans Administration Medical Center, New York 10468. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 501 EP - 510 VL - 10 IS - 4 SN - 0270-9139, 0270-9139 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Eating KW - Drinking KW - Animals KW - Animal Nutritional Physiological Phenomena KW - Diet KW - Administration, Inhalation KW - Food, Formulated KW - Ethanol -- administration & dosage KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79201985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Experimental+methods+of+ethanol+administration.&rft.au=Lieber%2C+C+S%3BDeCarli%2C+L+M%3BSorrell%2C+M+F&rft.aulast=Lieber&rft.aufirst=C&rft.date=1989-10-01&rft.volume=10&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypocholesterolemia in patients treated with recombinant interleukin-2: appearance of remnant-like lipoproteins. AN - 79200625; 2789275 AB - Reversible acute hypocholesterolemia was observed during treatment of metastatic cancer with high-dose intravenous recombinant interleukin-2 (IL-2). Further analysis revealed virtual disappearance of high-density lipoproteins (HDLs) and marked reduction in the concentration of low-density lipoproteins (LDL); the remaining LDL and intermediate-density lipoproteins (IDL) were enriched in triglyceride relative to cholesterol and had broad-beta electrophoretic mobility, properties reminiscent of remnant lipoproteins. These changes differ qualitatively and quantitatively from those previously reported for other cytokines such as tumor necrosis factor (TNF) or the interferons (IFNs). JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Wilson, D E AU - Birchfield, G R AU - Hejazi, J S AU - Ward, J H AU - Samlowski, W E AD - Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 1573 EP - 1577 VL - 7 IS - 10 SN - 0732-183X, 0732-183X KW - Interleukin-2 KW - 0 KW - Lipoproteins, HDL KW - Lipoproteins, LDL KW - Recombinant Proteins KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Lipoproteins, LDL -- blood KW - Triglycerides -- blood KW - Kidney Neoplasms -- therapy KW - Lipoproteins, HDL -- blood KW - Humans KW - Melanoma -- therapy KW - Cholesterol -- blood KW - Interleukin-2 -- adverse effects KW - Metabolic Diseases -- chemically induced KW - Metabolic Diseases -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79200625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Hypocholesterolemia+in+patients+treated+with+recombinant+interleukin-2%3A+appearance+of+remnant-like+lipoproteins.&rft.au=Wilson%2C+D+E%3BBirchfield%2C+G+R%3BHejazi%2C+J+S%3BWard%2C+J+H%3BSamlowski%2C+W+E&rft.aulast=Wilson&rft.aufirst=D&rft.date=1989-10-01&rft.volume=7&rft.issue=10&rft.spage=1573&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-26 N1 - Date created - 1989-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bromine derivatives of amino acids as intermediates in the peroxidase-catalyzed formation of singlet oxygen. AN - 79196929; 2774574 AB - Recently, J. R. Kanofsky et al. (1988, J. Biol. Chem. 263, 9692-9696) reported that human eosinophils generated modest amounts of singlet oxygen. In the mechanism proposed, hypobromous acid (made from the peroxidase-catalyzed oxidation of bromide ion) reacted with hydrogen peroxide to form singlet oxygen. In contrast, human neutrophils, which generate both hypochlorous acid and hydrogen peroxide, do not make singlet oxygen. The failure of human neutrophils to generate singlet oxygen is due in part to the trapping of hypochlorous acid by endogenous amines. In this paper, I show that amino acids are much more effective traps for hypochlorous acid than for hypobromous acid. Glycine totally inhibits singlet oxygen generation from a model enzyme system composed of chloroperoxidase, hydrogen peroxide, and chloride ion, but causes only a 35% reduction in singlet oxygen generation from an analogous enzyme system containing bromide ion instead of chloride ion. The products of the reaction of hypobromous and glycine (presumably an equilibrium mixture of N-bromoglycine, N,N-dibromoglycine, and hypobromous acid) retain the ability to react with hydrogen peroxide to form singlet oxygen. In contrast, the products of the reaction of hypochlorous acid and glycine do not react with hydrogen peroxide to produce singlet oxygen. Similar results were obtained for L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-cystine, L-glutamic acid, L-glutamine, L-histidine, L-lysine, L-phenylalanine, L-proline, L-serine, and L-tyrosine. Thus, bromine derivatives of amino acids may act as intermediates in the peroxidase-catalyzed generation of singlet oxygen. JF - Archives of biochemistry and biophysics AU - Kanofsky, J R AD - Medical Service, Edward Hines, Jr., Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 229 EP - 234 VL - 274 IS - 1 SN - 0003-9861, 0003-9861 KW - Amino Acids KW - 0 KW - Singlet Oxygen KW - 17778-80-2 KW - Chlorine KW - 4R7X1O2820 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidases KW - EC 1.11.1.- KW - Chloride Peroxidase KW - EC 1.11.1.10 KW - Oxygen KW - S88TT14065 KW - Bromine KW - SBV4XY874G KW - Index Medicus KW - Photochemistry KW - Kinetics KW - Hydrogen Peroxide -- metabolism KW - Chloride Peroxidase -- metabolism KW - Oxygen -- metabolism KW - Amino Acids -- metabolism KW - Peroxidases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79196929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Bromine+derivatives+of+amino+acids+as+intermediates+in+the+peroxidase-catalyzed+formation+of+singlet+oxygen.&rft.au=Kanofsky%2C+J+R&rft.aulast=Kanofsky&rft.aufirst=J&rft.date=1989-10-01&rft.volume=274&rft.issue=1&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-12 N1 - Date created - 1989-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes. AN - 79190004; 2550479 AB - We studied the chemotactic peptide receptor/cytoskeletal interactions in HL-60 cells induced to differentiate with different agents and attempted to correlate these observations with the acquisition of different functional responses. Dibutyryl cyclic AMP-treated cells showed rapid superoxide anion production in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP) and slow, sustained response to phorbol myristate acetate (PMA). Retinoic acid-induced cells showed a slow, sustained response to both FMLP and PMA. Interferon-gamma-treated cells produced no superoxide anion on stimulation with FMLP, whereas tumor necrosis factor (TNF)-treated cells showed a slight response. Chemotactic peptide receptor association was the same in the HL-60 cells treated with different agents, despite marked differences in the superoxide anion generation and actin polymerization responses to FMLP and PMA in these cells. In mature neutrophils chemotactic peptide receptor association with the cytoskeleton was not affected by either pertussis or cholera toxin. However, both toxins inhibited FMLP-induced actin polymerization and superoxide anion generation. This suggested involvement of a G-protein similar to Gt, rather than Gi or Gs. Neither toxin had any effect on PMA-induced superoxide anion generation. These observations indicate that receptor association with the cytoskeleton may not have a significant role in affecting signal recognition and response. Among the several possible roles suggested, clearance of the occupied receptors may be the most important role of the cytoskeletal association. HL-60 cells induced to differentiate with different agents (because of their varied functional responses) might prove very useful in dissecting the molecular mechanisms regulating stimulus-induced activation of neutrophils. JF - Journal of cellular physiology AU - Rao, K M AU - Currie, M S AU - Cohen, H J AU - Weinberg, J B AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Durham, North Carolina 27705. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 119 EP - 125 VL - 141 IS - 1 SN - 0021-9541, 0021-9541 KW - Receptors, Formyl Peptide KW - 0 KW - Receptors, Immunologic KW - Tumor Necrosis Factor-alpha KW - Virulence Factors, Bordetella KW - Superoxides KW - 11062-77-4 KW - Tretinoin KW - 5688UTC01R KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Bucladesine KW - 63X7MBT2LQ KW - Interferon-gamma KW - 82115-62-6 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Virulence Factors, Bordetella -- pharmacology KW - Tretinoin -- pharmacology KW - Tumor Cells, Cultured KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Superoxides -- biosynthesis KW - Cholera Toxin -- pharmacology KW - Interferon-gamma -- pharmacology KW - Leukemia, Myeloid -- pathology KW - Cell Differentiation -- drug effects KW - Bucladesine -- pharmacology KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Receptors, Immunologic -- physiology KW - Neutrophils -- physiology KW - Cytoskeleton -- ultrastructure KW - Cytoskeleton -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79190004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Chemotactic+peptide+receptor-cytoskeletal+interactions+and+functional+correlations+in+differentiated+HL-60+cells+and+human+polymorphonuclear+leukocytes.&rft.au=Rao%2C+K+M%3BCurrie%2C+M+S%3BCohen%2C+H+J%3BWeinberg%2C+J+B&rft.aulast=Rao&rft.aufirst=K&rft.date=1989-10-01&rft.volume=141&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-25 N1 - Date created - 1989-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Absence of phorbol ester-induced down-regulation of myc protein in the phorbol ester-tolerant mutant of HL-60 promyelocytes. AN - 79164363; 2670202 AB - The human promyelocytic leukemia cell line HL-60 has an amplified number of copies of the protooncogene c-myc. It is induced to differentiate by exposure to the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA). We have developed a mutant phorbol ester-tolerant (PET) line of HL-60 which undergoes a transient growth arrest but does not differentiate when exposed to TPA (Macfarlane et al., Br. J. Haematol., 68: 291-302, 1988). The defect is not due to a general failure of TPA-induced phosphorylation. In this paper, we show that exposing phorbol ester-sensitive (S) HL-60 cells to TPA caused the disappearance of the c-myc protein antigen (detected on Western blots) in 4 h, whereas TPA had no effect on the c-myc protein content of PET cells. Dimethyl sulfoxide caused the rapid disappearance of the myc antigen in both cells. PET cells had slightly more copies of the c-myc gene detected on Southern blots than S cells. c-myc mRNA was equally unstable in both cells, as determined by Northern blots following actinomycin D. TPA induced the down-regulation of c-myc mRNA in S cells to a greater extent than in PET cells. Dimethyl sulfoxide caused a rapid down-regulation of c-myc mRNA in both cell lines. This shows that PET cells have a defect in the mechanism by which protein kinase C regulates c-myc transcription. Our results provide further evidence that reduction in c-myc expression is necessary for differentiation to occur in HL-60 cells. JF - Cancer research AU - Gailani, D AU - Cadwell, F J AU - O'Donnell, P S AU - Hromas, R A AU - Macfarlane, D E AD - Department of Internal Medicine, Iowa City Veterans Administration Medical Center, Iowa. Y1 - 1989/10/01/ PY - 1989 DA - 1989 Oct 01 SP - 5329 EP - 5333 VL - 49 IS - 19 SN - 0008-5472, 0008-5472 KW - Proto-Oncogene Proteins KW - 0 KW - Proto-Oncogene Proteins c-myc KW - RNA, Messenger KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Tumor Cells, Cultured -- metabolism KW - Blotting, Southern KW - Humans KW - RNA, Messenger -- analysis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Differentiation -- drug effects KW - Proto-Oncogene Proteins -- analysis KW - Proto-Oncogene Proteins -- metabolism KW - Leukemia, Promyelocytic, Acute -- metabolism KW - Leukemia, Promyelocytic, Acute -- genetics KW - Gene Expression Regulation -- drug effects KW - Gene Amplification -- drug effects KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79164363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Absence+of+phorbol+ester-induced+down-regulation+of+myc+protein+in+the+phorbol+ester-tolerant+mutant+of+HL-60+promyelocytes.&rft.au=Gailani%2C+D%3BCadwell%2C+F+J%3BO%27Donnell%2C+P+S%3BHromas%2C+R+A%3BMacfarlane%2C+D+E&rft.aulast=Gailani&rft.aufirst=D&rft.date=1989-10-01&rft.volume=49&rft.issue=19&rft.spage=5329&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-05 N1 - Date created - 1989-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methionine recycling as a target for antiprotozoal drug development. AN - 78815832; 15463143 AB - The development of new and effective ontiprotozool drugs has been difficult because of the close metabolic relationship between protozoa and mammalian cells. In this article, Michael Riscoe, Al Ferro and john Fitchen present their hypothesis for chemotherapeutic exploitation of methylthioribose (MTR) kinase, an enzyme critical to methionine salvage in certain protozoa. They propose that analogues of MTR if properly designed, would be converted to toxic products in organisms that contain MTR kinase but not in mammalian cells, which lack this enzyme. JF - Parasitology today (Personal ed.) AU - Riscoe, M K AU - Ferro, A J AU - Fitchen, J H AD - M. Riscoe and J. Fitchen are at the Medical Research Service, Veterans Administration Medical Center, Portland, OR 97207, USA. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 330 EP - 333 VL - 5 IS - 10 SN - 0169-4758, 0169-4758 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78815832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Parasitology+today+%28Personal+ed.%29&rft.atitle=Methionine+recycling+as+a+target+for+antiprotozoal+drug+development.&rft.au=Riscoe%2C+M+K%3BFerro%2C+A+J%3BFitchen%2C+J+H&rft.aulast=Riscoe&rft.aufirst=M&rft.date=1989-10-01&rft.volume=5&rft.issue=10&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Parasitology+today+%28Personal+ed.%29&rft.issn=01694758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-18 N1 - Date created - 2004-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Parasitol Today. 1990 Mar;6(3):76 [15463301] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward a Social Movement for Adult Residential Care AN - 61466308; 199001529 AB - Based on clinical social work practice experience, research in adult foster care, & a review of the literature, it is argued that adult residential care is analogous to a poor stepchild when compared with the nursing home industry. In particular, adult residential care (1) has been inadequately developed conceptually & has a low profile as a consequence, (2) lacks a uniform national policy & has inadequate formal regulation, (3) has inadequate funding sources, & (4) is identified as a form of social health care. In contrast, the nursing home industry is known as a form of extended medical care, & benefits from its close association with the medical model. Political process & social insurgency paradigms of social movements are proferred as the only mechanisms whereby the quality of life for adult residential care residents can be elevated, not to mention the empowerment of the industry. It is hypothesized that a reform movement is needed to empower adult residential care, which would require the full-time efforts of a charismatic moral crusader who should have expertise in the conflict perspective, can apply the concept of cognitive liberation, & has an effective communication network. 38 References. Modified AA JF - Adult Residential Care Journal AU - McCoin, John M AD - Veterans Administration Medical Center, Leavenworth KS 66048 Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 161 EP - 180 VL - 3 IS - 3 SN - 0899-1995, 0899-1995 KW - adult residential care, reform movement need identified KW - clinical experience, literature review KW - Treatment Programs KW - Residential Institutions KW - Adults KW - Treatment Methods KW - Reform KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61466308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adult+Residential+Care+Journal&rft.atitle=Toward+a+Social+Movement+for+Adult+Residential+Care&rft.au=McCoin%2C+John+M&rft.aulast=McCoin&rft.aufirst=John&rft.date=1989-10-01&rft.volume=3&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Adult+Residential+Care+Journal&rft.issn=08991995&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Residential Institutions; Adults; Reform; Treatment Programs; Treatment Methods ER - TY - JOUR T1 - Alcoholism in the elderly. How to spot and treat a problem the patient wants to hide. AN - 79208221; 2780442 AB - Alcoholism is a disease that warrants a complete medical workup and vigorous intervention in all age-groups, including the elderly. Increased awareness of the problem, with early diagnosis and treatment, can reduce mortality and morbidity. Alcoholics are at risk for relapse, so physicians should be patient and positive in their approach. Especially in the elderly, obtaining a list of all prescribed and over-the-counter medications used is an important starting point. Nonessential drugs should be discontinued and use of any others closely monitored. If a withdrawal syndrome results from discontinuation of alcohol, thiamine, multivitamins, and sedatives should be prescribed as clinically indicated. Treatment of any underlying psychiatric disorder is important. Psychosocial intervention is essential in dealing with recovering elderly alcoholics to overcome loneliness and to enhance sobriety. A formal rehabilitative effort is mandatory. Long-term rehabilitation focuses on group support and may include use of disulfiram (Antabuse). JF - Postgraduate medicine AU - Tobias, C R AU - Lippmann, S AU - Pary, R AU - Oropilla, T AU - Embry, C K AD - Veterans Administration Medical Center, Louisville, KY 40202. Y1 - 1989/09/15/ PY - 1989 DA - 1989 Sep 15 SP - 67 EP - 70, 75-9 VL - 86 IS - 4 SN - 0032-5481, 0032-5481 KW - Vitamins KW - 0 KW - Ethanol KW - 3K9958V90M KW - Disulfiram KW - TR3MLJ1UAI KW - Abridged Index Medicus KW - Index Medicus KW - Ethanol -- blood KW - Self Disclosure KW - Drug Interactions KW - Disulfiram -- therapeutic use KW - Vitamins -- therapeutic use KW - Humans KW - Personality KW - Aged KW - Alcoholics Anonymous KW - Alcohol Withdrawal Delirium -- drug therapy KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnosis KW - Alcoholism -- therapy KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79208221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Alcoholism+in+the+elderly.+How+to+spot+and+treat+a+problem+the+patient+wants+to+hide.&rft.au=Tobias%2C+C+R%3BLippmann%2C+S%3BPary%2C+R%3BOropilla%2C+T%3BEmbry%2C+C+K&rft.aulast=Tobias&rft.aufirst=C&rft.date=1989-09-15&rft.volume=86&rft.issue=4&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-18 N1 - Date created - 1989-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hostility as a health risk factor: relationships with neuroticism, Type A behavior, attentional focus, and interpersonal style. AN - 85255066; pmid-2808731 AB - In order to investigate further the psychological construct of hostility measured on the Cook-Medley (Ho) Scale as a health risk factor, the present study examined relationships between hostility assessed on the Ho Scale and several measures of neuroticism, Type A behavior, and attentional and interpersonal style, using bivariate and hierarchical multiple regression analyses. Subjects were 204 psychologically normal, physically healthy males. Significant relationships were found between hostility, neuroticism, attentional overload, and interpersonal alienation. The present study provided normative data on several important health-related psychological dimensions in a sample of healthy normals. The findings also provided further support for the relationship between the hostility construct measured on the Ho Scale and measures of neuroticism as possible dimensions of disease-prone personality. JF - Journal of Clinical Psychology AU - Carmody, T P AU - Crossen, J R AU - Wiens, A N AD - San Francisco Veterans Administration Medical Center, Psychology Service, CA 94121. PY - 1989 SP - 754 EP - 762 VL - 45 IS - 5 SN - 0021-9762, 0021-9762 KW - Coronary Disease KW - Support, U.S. Gov't, P.H.S. KW - Self Concept KW - Personality Tests KW - Risk Factors KW - Neurotic Disorders KW - Human KW - Adult KW - Interpersonal Relations KW - Support, Non-U.S. Gov't KW - Psychometrics KW - Male KW - Hostility KW - Type A Personality KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85255066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Hostility+as+a+health+risk+factor%3A+relationships+with+neuroticism%2C+Type+A+behavior%2C+attentional+focus%2C+and+interpersonal+style.&rft.au=Carmody%2C+T+P%3BCrossen%2C+J+R%3BWiens%2C+A+N&rft.aulast=Carmody&rft.aufirst=T&rft.date=1989-09-01&rft.volume=45&rft.issue=5&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The immediate effects of cessation of cigarette smoking on gastroesophageal reflux. AN - 85221917; pmid-2773902 AB - Cigarette smoking is thought to adversely affect gastroesophageal reflux. Eight male patients with endoscopic evidence of gastroesophageal reflux had 24-h esophageal pH monitoring while smoking at least 20 cigarettes. This was repeated while abstaining from smoking the following day. In the initial study period, 28.3% of the reflux time occurred within 20 min of smoking a cigarette. There were fewer reflux episodes in the nonsmoking period (95.7 episodes vs 70.0). The patients had significant improvement while in the upright position (57 reflux episodes vs 28.5). Yet, total reflux time was not significantly changed (pH less than 4.0 11.2% of total time smoking vs 10.1% total time nonsmoking). Immediate cessation of smoking decreases the number of daily reflux episodes, but does not significantly affect total esophageal acid exposure in symptomatic patients with endoscopic evidence of gastro-esophageal reflux disease. JF - The American Journal of Gastroenterology AU - Waring, J P AU - Eastwood, T F AU - Austin, J M AU - Sanowski, R A AD - Division of Gastroenterology, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona. PY - 1989 SP - 1076 EP - 1078 VL - 84 IS - 9 SN - 0002-9270, 0002-9270 KW - Smoking KW - Human KW - Adult KW - Aged KW - Middle Age KW - Gastric Acidity Determination KW - Monitoring, Physiologic KW - Posture KW - Gastroesophageal Reflux KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85221917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=The+immediate+effects+of+cessation+of+cigarette+smoking+on+gastroesophageal+reflux.&rft.au=Waring%2C+J+P%3BEastwood%2C+T+F%3BAustin%2C+J+M%3BSanowski%2C+R+A&rft.aulast=Waring&rft.aufirst=J&rft.date=1989-09-01&rft.volume=84&rft.issue=9&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. AN - 79328970; 2510595 AB - To determine whether artemether, a derivative of the antimalarial agent qinghaosu, is therapeutically active against Schistosoma mansoni, we determined the in vitro, in vivo, and histopathologic effects of the drug on S. mansoni worms. In vitro, toxic effects of artemether on S. mansoni were not seen at concentrations of less than 100 micrograms/ml. However, in vivo, 30 and 50% reductions in the lengths of male and female worms, respectively, were observed 14 days after treatment. By 56 days worm dimensions had returned to control values. Similar reversible effects on male testes and female ovaries were seen. In vivo, a single oral dose of artemether (300 mg/kg) induced a shift of worms towards the liver within 8 h after treatment. By 3 and 14 days after treatment, 99 and 76%, respectively, of worms were still in the liver. In vivo, the therapeutic effect of artemether on adult S. mansoni treated on day 56 after infection was modest. Doses as high as 1,200 mg (200 mg/kg per day, six doses) resulted in a worm reduction rate of only 39%. However, in infected mice treated on day 14 or 21 after infection, worm reduction rates of 83 to 98% were obtained. Thus, artemether exhibited modest in vitro and in vivo activities against adult S. mansoni but was twofold more active against 2- to 3-week-old liver-stage parasites. JF - Antimicrobial agents and chemotherapy AU - Xiao, S H AU - Catto, B A AD - Department of Medicine, Veterans Administration Medical Center/Medical College of Georgia, Augusta 30912. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 1557 EP - 1562 VL - 33 IS - 9 SN - 0066-4804, 0066-4804 KW - Artemisinins KW - 0 KW - Schistosomicides KW - Sesquiterpenes KW - artemether KW - C7D6T3H22J KW - Index Medicus KW - Animals KW - Schistosomiasis mansoni -- parasitology KW - Mice, Inbred C3H KW - Liver -- parasitology KW - Mice KW - Schistosomiasis mansoni -- drug therapy KW - Snails -- parasitology KW - Male KW - Mice, Inbred DBA KW - Schistosomicides -- therapeutic use KW - Schistosoma mansoni -- drug effects KW - Schistosoma mansoni -- growth & development KW - Schistosomicides -- pharmacology KW - Sesquiterpenes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79328970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=In+vitro+and+in+vivo+studies+of+the+effect+of+artemether+on+Schistosoma+mansoni.&rft.au=Xiao%2C+S+H%3BCatto%2C+B+A&rft.aulast=Xiao&rft.aufirst=S&rft.date=1989-09-01&rft.volume=33&rft.issue=9&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-12 N1 - Date created - 1989-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Trop Med Hyg. 1972 Nov;21(6):951-8 [4628996] Yao Xue Xue Bao. 1982 Mar;17(3):187-93 [7115549] Mol Pharmacol. 1983 Sep;24(2):291-9 [6193406] Biochem Pharmacol. 1983 Sep 1;32(17):2463-6 [6351863] Trans R Soc Trop Med Hyg. 1987;81(5):710-4 [3329778] Yao Xue Xue Bao. 1983 Aug;18(8):619-21 [6677044] Science. 1985 May 31;228(4703):1049-55 [3887571] J Infect Dis. 1985 Jun;151(6):1130-7 [3998507] Q J Med. 1986 Feb;58(226):95-110 [3520628] Trans R Soc Trop Med Hyg. 1983;77(4):522-3 [6356505] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Co-morbidity: lessons learned about post-traumatic stress disorder (PTSD) from developing PTSD scales for the MMPI. AN - 79294283; 2808726 AB - Results from efforts to develop and validate PTSD measures are promising, but a "gold standard" has not been achieved. Keane, Malloy, and Fairbank (1984) have developed an MMPI PTSD subscale that has been cross-validated with clinicians' classification of PTSD at acceptable levels of agreement, specificity, and sensitivity. There is, however, room for improvement. Empirical evidence is presented that indicates that the next round of efforts to increase reliability and validity of PTSD measures must account for the presence/absence of co-morbidity (i.e., the simultaneous occurrence of other psychiatric disorders). For example, differences are noted in MMPI group profiles and PTSD scales between psychiatric patients and substance abusers. Second, different MMPI items emerge as indicative of PTSD; these vary as a function of the presence of other Axis I disorders among groups of Vietnam combat veterans who seek treatment for substance abuse. Results substantiate that different MMPI items for classifying PTSD occur with groups that differ in co-morbidity. Improvements in PTSD scale development are more likely when the contributions of pre-existing or subsequently co-occurring psychiatric disorders are taken in account, as well as variations in level of personality maturity. The evidence suggests that a "family" of PTSD scales need to be developed that take into account co-morbidity differences. JF - Journal of clinical psychology AU - Penk, W AU - Robinowitz, R AU - Black, J AU - Dolan, M AU - Bell, W AU - Roberts, W AU - Skinner, J AD - Veterans Administration Medical Center Boston, Massachusetts. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 709 EP - 717 VL - 45 IS - 5 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Psychotic Disorders -- psychology KW - Humans KW - Adult KW - Psychometrics KW - Alcoholism -- psychology KW - Mood Disorders -- psychology KW - Male KW - Vietnam KW - Combat Disorders -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Adaptation, Psychological KW - MMPI KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79294283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Co-morbidity%3A+lessons+learned+about+post-traumatic+stress+disorder+%28PTSD%29+from+developing+PTSD+scales+for+the+MMPI.&rft.au=Penk%2C+W%3BRobinowitz%2C+R%3BBlack%2C+J%3BDolan%2C+M%3BBell%2C+W%3BRoberts%2C+W%3BSkinner%2C+J&rft.aulast=Penk&rft.aufirst=W&rft.date=1989-09-01&rft.volume=45&rft.issue=5&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethnicity: post-traumatic stress disorder (PTSD) differences among black, white, and Hispanic veterans who differ in degrees of exposure to combat in Vietnam. AN - 79292759; 2808728 AB - Clinical observations and empirical evidence suggest that, among Vietnam combat veterans, Blacks are more maladjusted than Whites (e.g., Parsons, 1985; Penk et al., 1985). The prediction that minority group status is associated with poorer post-war adjustment and higher rates of PTSD was examined among Vietnam combat veterans who were seeking treatment for addiction disorders. Adjustment scores among groups comparable in combat exposure were found to be similar for both Whites and Hispanics; Blacks, however, score significantly higher on both PTSD symptoms on MMPI scales. These findings indicate that ethnicity contributes importantly to PTSD in selected instances, but that minority group status alone does not account for observed differences. Additional research is indicated in which careful attention is given to the complicating and interacting role of addiction disorders in sampling. JF - Journal of clinical psychology AU - Penk, W E AU - Robinowitz, R AU - Black, J AU - Dolan, M AU - Bell, W AU - Dorsett, D AU - Ames, M AU - Noriega, L AD - Psychology Service, Veterans Administration Medical Center, Boston, MA 02130. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 729 EP - 735 VL - 45 IS - 5 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Adaptation, Psychological KW - Humans KW - MMPI KW - Adult KW - Follow-Up Studies KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - African Continental Ancestry Group KW - Vietnam KW - Stress Disorders, Post-Traumatic -- ethnology KW - Combat Disorders -- psychology KW - African Americans -- psychology KW - Veterans -- psychology KW - Hispanic Americans -- psychology KW - Combat Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79292759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Ethnicity%3A+post-traumatic+stress+disorder+%28PTSD%29+differences+among+black%2C+white%2C+and+Hispanic+veterans+who+differ+in+degrees+of+exposure+to+combat+in+Vietnam.&rft.au=Penk%2C+W+E%3BRobinowitz%2C+R%3BBlack%2C+J%3BDolan%2C+M%3BBell%2C+W%3BDorsett%2C+D%3BAmes%2C+M%3BNoriega%2C+L&rft.aulast=Penk&rft.aufirst=W&rft.date=1989-09-01&rft.volume=45&rft.issue=5&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contrast media-induced lipid peroxidation in the rat kidney. AN - 79285523; 2807823 AB - Lipid peroxidation of biological membranes is often implicated in tissue injury. The authors compared the effects of ionic and nonionic contrast media (CM) on the induction of lipid peroxidation in rat kidney and its impact on renal function. Male Wistar rats weighing 200 to 230 grams were dehydrated for 24 hours and divided into 6 groups (n = 15/group). On day 0, groups 1 through 3 were injected with 25% glycerol (10 mL/kg, im) and rats from groups 4 through 6 received an equivalent amount of intramuscular saline. The next day, rats from groups 1 and 4 were injected with normal saline (10 mL/kg, iv); groups 2 and 5 received the ionic CM, diatrizoate, and groups 3 and 6 received the nonionic CM, iopromide. Each CM was tested at 10 mL/kg BW. At 24-hour intervals, 5 rats from each group were sacrificed. In rats injected with CM (diatrizoate or iopromide) alone, no changes in serum creatinine or kidney structure were demonstrated. In glycerol treated rats, a peak in serum creatinine was seen on day 2 which returned to normal level by day 4. Histologic changes included focal tubular damage and intraluminal debris. Malondialdehyde (MDA), a marker of lipid peroxidation concentration was higher than in controls (P less than 0.05). In diatrizoate-injected rats, increase in serum creatinine on day 4 was ten times higher than glycerol; severe morphological alterations in proximal tubules were noted and significant increases in renal MDA concentration were obtained (P less than .05). Iopromide (on day 4), caused a five-fold increase in serum creatinine compared with glycerol.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Investigative radiology AU - Parvez, Z AU - Rahman, M A AU - Moncada, R AD - Radiology Research Laboratory, Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 697 EP - 702 VL - 24 IS - 9 SN - 0020-9996, 0020-9996 KW - Contrast Media KW - 0 KW - Diatrizoate KW - 117-96-4 KW - Iohexol KW - 4419T9MX03 KW - iopromide KW - 712BAC33MZ KW - Creatinine KW - AYI8EX34EU KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Kidney Diseases -- pathology KW - Kidney Diseases -- metabolism KW - Diatrizoate -- pharmacology KW - Animals KW - Iohexol -- pharmacology KW - Creatinine -- blood KW - Male KW - Kidney Diseases -- chemically induced KW - Kidney -- metabolism KW - Kidney -- pathology KW - Lipid Peroxidation -- drug effects KW - Kidney -- drug effects KW - Contrast Media -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79285523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Contrast+media-induced+lipid+peroxidation+in+the+rat+kidney.&rft.au=Parvez%2C+Z%3BRahman%2C+M+A%3BMoncada%2C+R&rft.aulast=Parvez&rft.aufirst=Z&rft.date=1989-09-01&rft.volume=24&rft.issue=9&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-28 N1 - Date created - 1989-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cisplatin-induced neurotoxicity with seizures in frogs. AN - 79261116; 2802533 AB - Cis-diamminedichloroplatinum II (cisplatin) given by injection to adult frogs (Rana pipiens) resulted in tonic-clonic seizures 3 to 5 weeks later. The seizures could be induced multiple times; the animals appeared entirely normal between seizures. In the spinal cord there was vacuolation in the anterior grey horns. Ultrastructurally, the vacuoles consisted of swollen astrocytic processes in the neuropil and around neurons. Generalized edema with swelling of perivascular astrocyte foot processes was not seen. Systemic administration of cisplatin to frogs results in neurotoxicity with seizures and astrocytic swelling in the spinal cord. JF - Annals of neurology AU - Blisard, K S AU - Harrington, D A AD - Research Service, Veterans Administration Medical Center, Albuquerque, NM 87108. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 336 EP - 341 VL - 26 IS - 3 SN - 0364-5134, 0364-5134 KW - Neurotoxins KW - 0 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Rana pipiens KW - Animals KW - Atrophy KW - Seizures -- chemically induced KW - Seizures -- physiopathology KW - Cisplatin -- toxicity KW - Neurotoxins -- pharmacology KW - Seizures -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79261116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Cisplatin-induced+neurotoxicity+with+seizures+in+frogs.&rft.au=Blisard%2C+K+S%3BHarrington%2C+D+A&rft.aulast=Blisard&rft.aufirst=K&rft.date=1989-09-01&rft.volume=26&rft.issue=3&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=03645134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-08 N1 - Date created - 1989-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity of IL-2 and Corynebacterium parvum following direct intracranial injection. AN - 79241537; 2795120 AB - The toxicity of IL-2 and/or C. Parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of IL-2, different solvents for the IL-2, and different doses and routes of administration of C. Parvum. Two injections was found significantly to increase mortality (19%) over a single injection (4%). Mortality from two injections of 30,000 U (23%) or 60,000 U (20%) was higher than from two injections of 15,000 U (12%). The mortality from two injections with normal saline as solvent was much higher (29%) than from two injections with sterile water (19%) or D5W (9%). Two injections of IL-2 given simultaneously with C. Parvum showed a much higher mortality (26%) than other doses and routes of C. Parvum administration. Mice dying acutely (6-24 days) of toxicity showed an extensive mononuclear infiltrate at the site of injection. The brains of surviving mice (sacrificed at 30 days) showed a mild residual mononuclear cell infiltrate with the exception of mice which had received IL-2 and C. Parvum simultaneously. Brains from this latter group had an extensive residual mononuclear cell infiltrate. JF - Journal of neuro-oncology AU - Sutton, R C AU - Kennedy, J AU - Duncan, J AU - Conley, F K AD - Section of Neurosurgery, Palo Alto Veterans Administration Medical Center, CA. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 261 EP - 267 VL - 7 IS - 3 SN - 0167-594X, 0167-594X KW - Bacterial Vaccines KW - 0 KW - Interleukin-2 KW - Index Medicus KW - Animals KW - Brain -- pathology KW - Mice, Inbred C3H KW - Mice KW - Male KW - Female KW - Injections, Intraventricular KW - Interleukin-2 -- administration & dosage KW - Bacterial Vaccines -- toxicity KW - Propionibacterium acnes -- immunology KW - Bacterial Vaccines -- administration & dosage KW - Interleukin-2 -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79241537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Toxicity+of+IL-2+and+Corynebacterium+parvum+following+direct+intracranial+injection.&rft.au=Sutton%2C+R+C%3BKennedy%2C+J%3BDuncan%2C+J%3BConley%2C+F+K&rft.aulast=Sutton&rft.aufirst=R&rft.date=1989-09-01&rft.volume=7&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-17 N1 - Date created - 1989-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Esophageal ulceration associated with 13-cis-retinoic acid therapy in patients with Barrett's esophagus. AN - 79228170; 2792680 JF - Gastrointestinal endoscopy AU - Fennerty, B AU - Sampliner, R AU - Garewal, H AD - Section of Gastroenterology and Hematology-Oncology, Tucson Veterans Administration Medical Center, Arizona 85723. PY - 1989 SP - 442 EP - 443 VL - 35 IS - 5 SN - 0016-5107, 0016-5107 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Drug Evaluation KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Barrett Esophagus -- drug therapy KW - Peptic Ulcer -- chemically induced KW - Tretinoin -- adverse effects KW - Esophageal Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79228170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy&rft.atitle=Esophageal+ulceration+associated+with+13-cis-retinoic+acid+therapy+in+patients+with+Barrett%27s+esophagus.&rft.au=Fennerty%2C+B%3BSampliner%2C+R%3BGarewal%2C+H&rft.aulast=Fennerty&rft.aufirst=B&rft.date=1989-09-01&rft.volume=35&rft.issue=5&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy&rft.issn=00165107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-17 N1 - Date created - 1989-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin. AN - 79212222; 2782396 AB - Calf pulmonary artery endothelial monolayers cultured on polycarbonate filters were utilized to study 125I-labeled albumin permeability and actin filament distribution in response to thrombin challenge. Thirty-minute exposure to alpha-thrombin (10(-7) M) significantly increased albumin clearance rates. These changes were associated with marked alterations in actin filament distribution, resulting in loss of peripheral actin bands and an increase in the number of cytoplasmic stress fibers. Because the actin peripheral filaments are thought to play an important role in junctional stability, we postulated that stabilization of actin filaments should protect against thrombin-induced barrier disruptions. Pretreatment of cells with 0.3 microM 7-nitrobenz-2-oxa-1,3-diazole (NBD)-phallacidin, a specific actin-stabilizing agent, prevented the changes in actin filament distribution and markedly attenuated the increase in albumin permeability. Because of the potential toxicity of phallatoxins, we evaluated the effects of pretreatment on cell viability and growth parameters. There were no differences in viability, seeding efficiency, or doubling times in cells treated with 0.3 microM NBD-phallacidin in comparison to controls. Our data support the hypothesis that actin filaments, particularly peripheral bands, contribute significantly to the maintenance of barrier function in cultured endothelial cells. JF - The American journal of physiology AU - Phillips, P G AU - Lum, H AU - Malik, A B AU - Tsan, M F AD - Research Service, Veterans Administration Medical Center, Albany, New York. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - C562 EP - C567 VL - 257 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Actins KW - 0 KW - Albumins KW - Peptides, Cyclic KW - phallacidin KW - 26645-35-2 KW - Thrombin KW - EC 3.4.21.5 KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Actins -- physiology KW - Cattle KW - Cell Survival -- drug effects KW - Cell Membrane -- drug effects KW - Cell Division -- drug effects KW - Actins -- metabolism KW - Cell Membrane -- physiology KW - Cell Membrane -- metabolism KW - Time Factors KW - Albumins -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- cytology KW - Thrombin -- pharmacology KW - Cell Membrane Permeability -- drug effects KW - Albumins -- pharmacokinetics KW - Peptides, Cyclic -- pharmacokinetics KW - Peptides, Cyclic -- pharmacology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79212222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Phallacidin+prevents+thrombin-induced+increases+in+endothelial+permeability+to+albumin.&rft.au=Phillips%2C+P+G%3BLum%2C+H%3BMalik%2C+A+B%3BTsan%2C+M+F&rft.aulast=Phillips&rft.aufirst=P&rft.date=1989-09-01&rft.volume=257&rft.issue=3+Pt+1&rft.spage=C562&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-18 N1 - Date created - 1989-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Irrational beliefs, urges to drink and drinking among alcoholics. AN - 79199385; 2779249 AB - The relationship of various irrational beliefs to alcohol dependence, urges to drink, anxiety and drinking after treatment was investigated for 63 male alcoholics, using Jones' Irrational Beliefs Test (IBT). Alcohol dependence was most strongly associated with problem avoidance. Urges to drink, anxiety and difficulty during alcohol-related role-plays were strongly correlated with problem avoidance and dwelling on negative events. The IBT was unrelated to pretreatment drinking measures but did predict 6-month posttreatment drinking (n = 48) which suggests these beliefs can mediate treatment response. Feeling doomed by the past was the best predictor of both frequency of drinking and average quantity consumed during follow-up. Treatment implications include targeting specific beliefs for intervention. JF - Journal of studies on alcohol AU - Rohsenow, D J AU - Monti, P M AU - Zwick, W R AU - Nirenberg, T D AU - Liepman, M R AU - Binkoff, J A AU - Abrams, D B AD - Psychology Service, Veterans Administration Medical Center, Providence, RI 02908. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 461 EP - 464 VL - 50 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Internal-External Control KW - Personality Tests KW - Adaptation, Psychological KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Problem Solving KW - Alcoholism -- rehabilitation KW - Alcohol Drinking -- psychology KW - Attitude KW - Alcoholism -- psychology KW - Mood Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Irrational+beliefs%2C+urges+to+drink+and+drinking+among+alcoholics.&rft.au=Rohsenow%2C+D+J%3BMonti%2C+P+M%3BZwick%2C+W+R%3BNirenberg%2C+T+D%3BLiepman%2C+M+R%3BBinkoff%2C+J+A%3BAbrams%2C+D+B&rft.aulast=Rohsenow&rft.aufirst=D&rft.date=1989-09-01&rft.volume=50&rft.issue=5&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-18 N1 - Date created - 1989-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol withdrawal in the elderly. AN - 79197856; 2779242 AB - The phenomenon of alcohol withdrawal has seldom been studied in subgroups of patients in withdrawal. We developed a rating scale for measuring alcohol withdrawal that we found to be reliable and valid. The scale, when applied to young (ages 21-33, N = 24) and elderly (ages 58-77, N = 26) groups of patients in alcohol withdrawal, indicated that the elderly group initially had a more severe withdrawal for which they received higher doses of chlordiazepoxide. JF - Journal of studies on alcohol AU - Liskow, B I AU - Rinck, C AU - Campbell, J AU - DeSouza, C AD - Veterans Administration Outpatient Clinic, Columbus, Ohio 43221. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 414 EP - 421 VL - 50 IS - 5 SN - 0096-882X, 0096-882X KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Index Medicus KW - Age Factors KW - Humans KW - Chlordiazepoxide -- therapeutic use KW - Adult KW - Aged KW - Psychiatric Department, Hospital KW - Middle Aged KW - Male KW - Female KW - Psychological Tests KW - Alcoholism -- rehabilitation KW - Psychoses, Alcoholic -- rehabilitation KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Alcohol Withdrawal Delirium -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79197856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Alcohol+withdrawal+in+the+elderly.&rft.au=Liskow%2C+B+I%3BRinck%2C+C%3BCampbell%2C+J%3BDeSouza%2C+C&rft.aulast=Liskow&rft.aufirst=B&rft.date=1989-09-01&rft.volume=50&rft.issue=5&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-18 N1 - Date created - 1989-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validation of a diagnostic test. Epidemiologic principles in dermatology. AN - 79197545; 2774603 JF - Archives of dermatology AU - Weinstock, M A AD - Department of Dermatology, Brown University, Veterans Administration Medical Center, Providence, RI 02908. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 1260 EP - 1264 VL - 125 IS - 9 SN - 0003-987X, 0003-987X KW - Methotrexate KW - YL5FZ2Y5U1 KW - Abridged Index Medicus KW - Index Medicus KW - ROC Curve KW - Humans KW - Biopsy KW - Liver -- pathology KW - Methotrexate -- adverse effects KW - Liver -- drug effects KW - Psoriasis -- drug therapy KW - Predictive Value of Tests KW - Liver Function Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79197545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Validation+of+a+diagnostic+test.+Epidemiologic+principles+in+dermatology.&rft.au=Weinstock%2C+M+A&rft.aulast=Weinstock&rft.aufirst=M&rft.date=1989-09-01&rft.volume=125&rft.issue=9&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-03 N1 - Date created - 1989-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methyltestosterone-induced cholestasis. The importance of disproportionately low serum alkaline phosphatase level. AN - 79197067; 2774790 AB - We describe a 64-year-old man who developed cholestatic jaundice after receiving 20 to 40 mg of methyltestosterone daily for 6 months for impotence but failed to mention it as part of his drug history. He underwent endoscopic retrograde and papillotomy before a positive history for methyltestosterone ingestion could be obtained. Since methyltestosterone is most often used for sexual impotence, the patient may be quite reluctant to mention this hormone as part of his medication. A normal or mildly elevated alkaline phosphatase level, disproportionate to the level of hyperbilirubinemia seen in this patient and in all previous reports, appears to be characteristic of this phenomenon. This pattern of liver function abnormality can be a clue to suspect methyltestosterone as the causative agent and spare the patient unneeded expensive noninvasive and potentially harmful invasive procedures. JF - Archives of internal medicine AU - Borhan-Manesh, F AU - Farnum, J B AD - Department of Medicine, Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 2127 EP - 2129 VL - 149 IS - 9 SN - 0003-9926, 0003-9926 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Methyltestosterone KW - V9EFU16ZIF KW - Abridged Index Medicus KW - Index Medicus KW - Liver -- pathology KW - Humans KW - Erectile Dysfunction -- drug therapy KW - Middle Aged KW - Biopsy KW - Male KW - Cholestasis -- chemically induced KW - Cholestasis -- pathology KW - Cholestasis -- enzymology KW - Methyltestosterone -- adverse effects KW - Alkaline Phosphatase -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79197067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Methyltestosterone-induced+cholestasis.+The+importance+of+disproportionately+low+serum+alkaline+phosphatase+level.&rft.au=Borhan-Manesh%2C+F%3BFarnum%2C+J+B&rft.aulast=Borhan-Manesh&rft.aufirst=F&rft.date=1989-09-01&rft.volume=149&rft.issue=9&rft.spage=2127&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-12 N1 - Date created - 1989-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemopreventive effect of N-homocysteine thiolactonyl retinamido cobalamin on carcinogenesis by ethyl carbamate in mice. AN - 79189040; 2771961 AB - Because of abnormalities of metabolism of homocysteine thiolactone and methionine in malignant cells, and because of the chemopreventive activity of N-homocysteine thiolactonyl retinamide against chemical carcinogenesis by ethyl carbamate in mice, the cobalamin derivative of this retinamide was prepared and tested for chemopreventive activity. The substance, N-homocysteine thiolactonyl retinamido cobalamin, was found to have a different UV-visible absorption spectrum from that of 5'-deoxyadenosyl cobalamin or N-homocysteine thiolactonyl retinamide. Spectral analysis suggests a ratio of 2 mol of retinamide/mol of cobalamin within the molecule. To demonstrate chemopreventive activity, ethyl carbamate was given in a dose of 2 mg/animal to A/J mice (15-18 g) weekly over a period of 10 weeks to induce pulmonary tumors. A total dose of N-homocysteine thiolactonyl retinamido cobalamin of 60 mg/kg, given for a total of 16 weeks, decreased by one fourth (P less than 0.05) the number of pulmonary tumors induced by ethyl carbamate. An equimolar dose of 5'-deoxyadenosyl cobalamin (40 mg/kg) increased the number of tumors by one third (P less than 0.001), and an equimolar dose of N-homocysteine thiolactonyl retinamide (20 mg/kg) had no effect on the number of pulmonary tumors. No mortality was observed in the experiment. When the ethyl carbamate was given in a single dose of 20 mg/animal, all three substances produced significant mortality in doses of 0.75-30 mg/kg. In the survivors of this experiment, doses of 0.75-30 mg/kg of N-homocysteine thiolactonyl retinamido cobalamin decreased the number of pulmonary tumors induced by ethyl carbamate to 52-82% of controls (P less than 0.01). The results show that N-homocysteine thiolactonyl retinamido cobalamin has chemopreventive activity against chemical carcinogenesis by ethyl carbamate in mice. JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) AU - McCully, K S AU - Vezeridis, M P AD - Veterans Administration Medical Center, Providence, Rhode Island 02908. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 346 EP - 351 VL - 191 IS - 4 SN - 0037-9727, 0037-9727 KW - Antineoplastic Agents KW - 0 KW - Homocysteine KW - 0LVT1QZ0BA KW - N-homocysteine thiolactonyl retinamide KW - 105918-76-1 KW - Urethane KW - 3IN71E75Z5 KW - Tretinoin KW - 5688UTC01R KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Animals KW - Spectrum Analysis KW - Vitamin B 12 -- pharmacology KW - Spectrophotometry, Ultraviolet KW - Mice KW - Tretinoin -- pharmacology KW - Homocysteine -- chemical synthesis KW - Urethane -- antagonists & inhibitors KW - Tretinoin -- analogs & derivatives KW - Neoplasms, Experimental -- chemically induced KW - Tretinoin -- chemical synthesis KW - Antineoplastic Agents -- chemical synthesis KW - Homocysteine -- pharmacology KW - Homocysteine -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79189040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.atitle=Chemopreventive+effect+of+N-homocysteine+thiolactonyl+retinamido+cobalamin+on+carcinogenesis+by+ethyl+carbamate+in+mice.&rft.au=McCully%2C+K+S%3BVezeridis%2C+M+P&rft.aulast=McCully&rft.aufirst=K&rft.date=1989-09-01&rft.volume=191&rft.issue=4&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-28 N1 - Date created - 1989-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Temporal lobe epilepsy: its association with psychiatric impairment and appropriate dental management. AN - 79178302; 2528104 AB - Temporal lobe seizures are manifested by aberrant experiences, automatic behavior, or both. In addition, approximately 40% of the patients who have had the disease for more than 15 years exhibit significant personality disorders, mood changes, or psychoses in the periods between seizures (interictal phase). Recognition that these characterologic manifestations are components of the underlying neurologic disorder allows for a more rational approach to the provision of dental care. JF - Oral surgery, oral medicine, and oral pathology AU - Friedlander, A H AU - Cummings, J L AD - Dental Service, Brentwood Division, West Los Angeles Veterans Administration Medical Center, Calif. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 288 EP - 292 VL - 68 IS - 3 SN - 0030-4220, 0030-4220 KW - Dentistry KW - Index Medicus KW - Humans KW - Mouth Diseases -- chemically induced KW - Epilepsy, Temporal Lobe -- psychology KW - Depressive Disorder -- drug therapy KW - Dental Care for Disabled KW - Schizophrenia -- drug therapy KW - Epilepsy, Temporal Lobe -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79178302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+surgery%2C+oral+medicine%2C+and+oral+pathology&rft.atitle=Temporal+lobe+epilepsy%3A+its+association+with+psychiatric+impairment+and+appropriate+dental+management.&rft.au=Friedlander%2C+A+H%3BCummings%2C+J+L&rft.aulast=Friedlander&rft.aufirst=A&rft.date=1989-09-01&rft.volume=68&rft.issue=3&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Oral+surgery%2C+oral+medicine%2C+and+oral+pathology&rft.issn=00304220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-12 N1 - Date created - 1989-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. AN - 79166543; 2766902 AB - Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids. Plain aspirin and nonsteroidal antiinflammatory drugs were discontinued in all patients. Seven patients received enteric-coated aspirin throughout the treatment phase and continuously for the entire study period (2.5-12 months). The remainder of patients (N = 16) did not receive enteric-coated aspirin. An endoscopy was performed to assess ulcer healing. None of seven patients receiving enteric-coated aspirin had complete healing of their ulcer(s) while 15 of 16 patients not receiving enteric-coated aspirin demonstrated complete healing of their ulcer(s) (P less than 0.001). An eight-week course of cimetidine and antacids is ineffective in completely healing gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory drugs while enteric-coated aspirin is continued. JF - Digestive diseases and sciences AU - Jaszewski, R AU - Calzada, R AU - Dhar, R AD - Division of Gastroenterology, Veterans Administration Medical Center, Allen Park, Michigan 48101. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 1361 EP - 1364 VL - 34 IS - 9 SN - 0163-2116, 0163-2116 KW - Antacids KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Tablets, Enteric-Coated KW - Cimetidine KW - 80061L1WGD KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Gastroscopy KW - Prospective Studies KW - Humans KW - Osteoarthritis -- drug therapy KW - Middle Aged KW - Male KW - Stomach Ulcer -- drug therapy KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cimetidine -- therapeutic use KW - Antacids -- therapeutic use KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79166543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Persistence+of+gastric+ulcers+caused+by+plain+aspirin+or+nonsteroidal+antiinflammatory+agents+in+patients+treated+with+a+combination+of+cimetidine%2C+antacids%2C+and+enteric-coated+aspirin.&rft.au=Jaszewski%2C+R%3BCalzada%2C+R%3BDhar%2C+R&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1989-09-01&rft.volume=34&rft.issue=9&rft.spage=1361&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-25 N1 - Date created - 1989-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical and immunologic significance of cholera-like toxin and cytotoxin production by Campylobacter species in patients with acute inflammatory diarrhea in the USA. AN - 79125277; 2760498 AB - The humoral immune response to both Campylobacter jejuni cell surface antigens and to potential toxins of the organism was studied in 64 adults with inflammatory diarrhea. In an enzyme-linked immunosorbent assay (ELISA) for surface antigens, 17 (71%) of 24 persons with Campylobacter enteritis showed seroconversion in more than one immunoglobulin class, versus only 2 (5%) of 40 patients with non-Campylobacter enteritis. In a GM1, ganglioside-based ELISA for detecting serum IgG to cholera-like enterotoxin, only one patient studied showed seroconversion to the enterotoxin. Of 22 Campylobacter isolates studied for production of cholera-like toxin, none of the supernatants from the Campylobacter strains were positive. Supernatants were also tested for enterotoxin and cytotoxic activity on Chinese hamster ovary cells; all isolates were negative for enterotoxin activity. In contrast, cytotoxin was produced by 7 (32%) isolates but was usually low-level and was not neutralized by patient's serum. These findings indicate that production of cholera-like toxin and cytotoxin by Campylobacter strains in the United States occurs in few strains and that host immune response is absent; their biologic significance in the pathogenesis of Campylobacter infections remains unclear. JF - The Journal of infectious diseases AU - Perez-Perez, G I AU - Cohn, D L AU - Guerrant, R L AU - Patton, C M AU - Reller, L B AU - Blaser, M J AD - Infectious Disease Section, Veterans Administration Medical Center, Denver, CO 80220. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 460 EP - 468 VL - 160 IS - 3 SN - 0022-1899, 0022-1899 KW - Antigens, Surface KW - 0 KW - Cytotoxins KW - Enterotoxins KW - Cholera Toxin KW - 9012-63-9 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Acute Disease KW - Humans KW - Enterotoxins -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Antibody Formation KW - Antigens, Surface -- analysis KW - Inflammation KW - Campylobacter -- pathogenicity KW - Diarrhea -- immunology KW - Campylobacter Infections -- immunology KW - Diarrhea -- microbiology KW - Campylobacter -- immunology KW - Cytotoxins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79125277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Clinical+and+immunologic+significance+of+cholera-like+toxin+and+cytotoxin+production+by+Campylobacter+species+in+patients+with+acute+inflammatory+diarrhea+in+the+USA.&rft.au=Perez-Perez%2C+G+I%3BCohn%2C+D+L%3BGuerrant%2C+R+L%3BPatton%2C+C+M%3BReller%2C+L+B%3BBlaser%2C+M+J&rft.aulast=Perez-Perez&rft.aufirst=G&rft.date=1989-09-01&rft.volume=160&rft.issue=3&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-19 N1 - Date created - 1989-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Histologic changes in the urinary bladder in relation to cigarette smoking and use of artificial sweeteners. AN - 79118099; 2758391 AB - A total of 6503 sections of urinary bladder epithelium from 282 subjects were examined in random order, and histologic alterations, particularly the number of cell rows and the presence and extent of cells with atypical nuclei, were recorded. Cases were either individuals who had never smoked or who had smoked cigarettes. Microscopic slides with cells having 50% or more atypical nuclei were found in 4.3% of those who had never smoked; 67.1% in those who had smoked less than 20 cigarettes a day; 82.3% in those who had smoked 20 to 39 cigarettes a day; and 88.4% of the 40 or more a day cigarette smokers. The percentage of slides with six or more cell rows in these groups were 4.8%, 52.2%, 62.5%, and 72.9%, respectively. The histologic findings in the urinary bladder in relation to smoking habits fully complement the epidemiologic studies showing a dose-response of cigarette smoking and urinary bladder cancer. No relationship was found between changes in the urinary bladder epithelium and the use of artificial sweeteners. JF - Cancer AU - Auerbach, O AU - Garfinkel, L AD - Veterans Administration Medical Center, East Orange, New Jersey 07019. Y1 - 1989/09/01/ PY - 1989 DA - 1989 Sep 01 SP - 983 EP - 987 VL - 64 IS - 5 SN - 0008-543X, 0008-543X KW - Sweetening Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Hyperplasia KW - Cell Nucleus -- pathology KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Epithelium -- pathology KW - Adolescent KW - Male KW - Female KW - Sweetening Agents -- adverse effects KW - Urinary Bladder Neoplasms -- pathology KW - Urinary Bladder Neoplasms -- etiology KW - Smoking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79118099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Histologic+changes+in+the+urinary+bladder+in+relation+to+cigarette+smoking+and+use+of+artificial+sweeteners.&rft.au=Auerbach%2C+O%3BGarfinkel%2C+L&rft.aulast=Auerbach&rft.aufirst=O&rft.date=1989-09-01&rft.volume=64&rft.issue=5&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-15 N1 - Date created - 1989-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronicity: Adjustment Differences of Vietnam Combat Veterans Differing in Rates of Psychiatric Hospitalization AN - 61581794; 199001425 AB - Frequency of inpatient care for patients with posttraumatic stress disorder (PTSD). This "chronicity," is examined via Minn Multiphasic Personality Inventory (MMPI) scores of 180 Vietnam combat & noncombat veterans admitted to inpatient psychiatry service. Results show that combat exposure is associated with greater maladjustment (ie, higher MMPI scores). Moreover, chronicity also emerged as a significantly important variable: of all groups compared, Vietnam combat veterans higher in chronicity scored higher on MMPI clinical scales, particularly on paranoia, psychasthenia, & schizophrenia scales, thereby empirically establishing the importance of chronicity in studies of PTSD. 3 Tables, 10 References. Modified HA JF - Journal of Clinical Psychology AU - Long, Robert AU - Wine, Pamela AU - Penk, Walter AU - Keane, Terence AU - Chew, David AU - Gerstein, Claire AU - O'Neill, John AU - Nadelson, Theodore AD - Veterans' Administration Medical Center, 150 S Huntington Boston MA 02130 Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 745 EP - 753 VL - 45 IS - 5 SN - 0021-9762, 0021-9762 KW - inpatient care frequency chronicity, posttraumatic stress disorder patients KW - inventory data KW - combat vs noncombat veterans, Vietnam War KW - Veterans KW - Psychological Stress KW - Vietnam War KW - Combat KW - Mental Illness KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61581794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Chronicity%3A+Adjustment+Differences+of+Vietnam+Combat+Veterans+Differing+in+Rates+of+Psychiatric+Hospitalization&rft.au=Long%2C+Robert%3BWine%2C+Pamela%3BPenk%2C+Walter%3BKeane%2C+Terence%3BChew%2C+David%3BGerstein%2C+Claire%3BO%27Neill%2C+John%3BNadelson%2C+Theodore&rft.aulast=Long&rft.aufirst=Robert&rft.date=1989-09-01&rft.volume=45&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Vietnam War; Veterans; Combat; Mental Illness ER - TY - JOUR T1 - Carcinogenicity and Teratogenicity vs. Psychogenicity: Psychological Characteristics Associated with Self-Reported Agent Orange Exposure among Vietnam Combat Veterns Who Seek Treatment for Substance Abuse AN - 61517417; 199001959 AB - An examination of the psychological characteristics of US Vietnam War combat veterns who claim Agent Orange exposure vs combat-experienced cohorts who do not report such contamination, based on data on heroin addicts, polydrug abusers, & chronic alcoholics who were admitted to substance abuse treatment programs. Of the respondents, 58 reported moderate to high defoliant exposure while in combat, while 95 reported minimal to no exposure while in Vietnam. The null hypothesis was accepted for measures of childhood & present family social climate, premilitary backgrounds, reasons for seeking treatment, patterns & types of illicit drug & alcohol use, interpersonal problems, intellectual functioning, & short-term memory. The null hypothesis was rejected for personality differences; however, those who self-reported high Agent Orange exposure scored significantly higher on hypochondriasis, depression, paranoia, psychasthenia, schizophrenia, mania, & social introversion scales. Results suggest that clinicians carefully assess attributional processing of those who report traumatic experience. Modified HA JF - Journal of Clinical Psychology AU - Robinowitz, Ralph AU - Roberts, W R AU - Dolan, M P AU - Patterson, E T AU - Charles, H L AU - Atkins, H G AU - Penk, Walter E AD - c/o Penk Psychology Service (116B) Veterans' Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 718 EP - 728 VL - 45 IS - 5 SN - 0021-9762, 0021-9762 KW - psychological characteristics, Vietnam War veterans, US KW - Agent Orange exposure KW - inventory/other data KW - substance abuse treatment clients KW - Toxic Substances KW - Veterans KW - Vietnam War KW - Psychosocial Factors KW - Health Problems KW - United States of America KW - Cancer KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61517417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Carcinogenicity+and+Teratogenicity+vs.+Psychogenicity%3A+Psychological+Characteristics+Associated+with+Self-Reported+Agent+Orange+Exposure+among+Vietnam+Combat+Veterns+Who+Seek+Treatment+for+Substance+Abuse&rft.au=Robinowitz%2C+Ralph%3BRoberts%2C+W+R%3BDolan%2C+M+P%3BPatterson%2C+E+T%3BCharles%2C+H+L%3BAtkins%2C+H+G%3BPenk%2C+Walter+E&rft.aulast=Robinowitz&rft.aufirst=Ralph&rft.date=1989-09-01&rft.volume=45&rft.issue=5&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Toxic Substances; Health Problems; Cancer; United States of America; Psychosocial Factors ER - TY - JOUR T1 - Driving While Intoxicated. Different Roads to and from the Problem AN - 20881143; 10299759 AB - Driving while intoxicated (DWI) continues to be a major societal concern, exacting a high personal and financial cost. The present article reviews the current scope of the drinking-driving problem and a number of countermeasures employed to reduce it. Primary prevention strategies target young drivers with the goal of preventing the initiation of drinking-driving behavior. Driver's training and drinking-driver education classes have had a minimal impact on DWI. Increasing the minimum age for purchasing alcohol has been considerably more effective. Secondary interventions target the general driving population and are based on the principles of general deterrence. Increasing the perceived risk of arrest and punishment appears to have a short-term impact; increased severity of punishment also has limited effects. Tertiary interventions, or specific deterrents, target convicted DWI offenders with the goal of reducing recidivism. Alcohol education and rehabilitation have shown only a weak positive impact on DWI. License suspension/revocation appears to be an effective and efficient specific deterrent. Overall, it is suggested that the approach with the greatest potential for reducing the drinking-driving problem is an integrated, complementary countermeasure aimed at both person and sociocultural factors. JF - Criminal Justice and Behavior AU - Donovan, Dennis M AD - Veterans Administration Medical Center Seattle, WA University of Washington Y1 - 1989/09// PY - 1989 DA - Sep 1989 SP - 270 EP - 298 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 16 IS - 3 SN - 0093-8548, 0093-8548 KW - Risk Abstracts KW - Alcohol KW - Age KW - arrests KW - Motor vehicles KW - Education KW - driving ability KW - Perception KW - intervention KW - Reviews KW - prevention KW - recidivism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20881143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Criminal+Justice+and+Behavior&rft.atitle=Driving+While+Intoxicated.+Different+Roads+to+and+from+the+Problem&rft.au=Donovan%2C+Dennis+M&rft.aulast=Donovan&rft.aufirst=Dennis&rft.date=1989-09-01&rft.volume=16&rft.issue=3&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Criminal+Justice+and+Behavior&rft.issn=00938548&rft_id=info:doi/10.1177%2F0093854889016003003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; Education; arrests; Perception; driving ability; Motor vehicles; Reviews; intervention; prevention; recidivism DO - http://dx.doi.org/10.1177/0093854889016003003 ER - TY - JOUR T1 - The effect of neuropeptide Y on drinking in mice. AN - 79165774; 2765911 AB - Neuropeptide Y (NPY) when administered intracerebroventricularly is a potent stimulator of feeding and drinking in rats. In these studies we demonstrated that, in contrast, in mice NPY inhibits drinking induced by water deprivation and that associated with food intake. In addition, we found that mice failed to respond to the rat dipsogen angiotensin II. Old mice demonstrated hypodipsia compared to young mice and NPY failed to inhibit drinking in older mice. Monosodium glutamate (MSG) administered neonatally produces lesions of the arcuate nucleus, an area rich in NPY cell bodies. NPY inhibited drinking and enhanced feeding in MSG treated mice. NPY also significantly inhibited the intake of water flavored with 8% sucrose and 0.1% quinine. NPY failed to alter ingestion of 0.2% or 5% saline. These studies support the contention that marked species differences exist in the regulation of water intake between rats and mice. JF - Brain research AU - Morley, J E AU - Flood, J F AD - Geriatric Research, Education and Clinical Center, Sepulveda Veterans Administration Medical Center, CA 91343. Y1 - 1989/08/07/ PY - 1989 DA - 1989 Aug 07 SP - 129 EP - 137 VL - 494 IS - 1 SN - 0006-8993, 0006-8993 KW - Glutamates KW - 0 KW - Neuropeptide Y KW - Angiotensin II KW - 11128-99-7 KW - Sodium Glutamate KW - W81N5U6R6U KW - Index Medicus KW - Animals KW - Mice KW - Male KW - Angiotensin II -- pharmacology KW - Injections, Intraventricular KW - Aging -- physiology KW - Drinking Behavior -- drug effects KW - Aging -- metabolism KW - Arcuate Nucleus of Hypothalamus -- physiology KW - Arcuate Nucleus of Hypothalamus -- drug effects KW - Neuropeptide Y -- pharmacology KW - Sodium Glutamate -- toxicity KW - Glutamates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79165774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+effect+of+neuropeptide+Y+on+drinking+in+mice.&rft.au=Morley%2C+J+E%3BFlood%2C+J+F&rft.aulast=Morley&rft.aufirst=J&rft.date=1989-08-07&rft.volume=494&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Congenital arteriovenous malformation rupturing into a true jejunal diverticulum. AN - 85221473; pmid-2502910 AB - Massive hemorrhage from the gastrointestinal tract of an elderly patient due to a hitherto unreported cause is described. A congenital arteriovenous malformation located in the submucosa of a true jejunal diverticulum ruptured into the lumen. Both selective angiographic demonstration and histologic documentation of the bleeding point are presented. The simultaneous presence of these two entities is probably not a coincidence and is discussed. JF - The American Journal of Gastroenterology AU - Chin, N W AU - Lai, C H AU - Harisiadis, S A AU - Chapman, I AD - Laboratory Service, Veterans Administration Medical Center, Brooklyn, New York. PY - 1989 SP - 972 EP - 974 VL - 84 IS - 8 SN - 0002-9270, 0002-9270 KW - Angiography KW - Jejunal Diseases KW - Human KW - Jejunum KW - Aged KW - Arteriovenous Malformations KW - Case Report KW - Rupture, Spontaneous KW - Diverticulum KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85221473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Congenital+arteriovenous+malformation+rupturing+into+a+true+jejunal+diverticulum.&rft.au=Chin%2C+N+W%3BLai%2C+C+H%3BHarisiadis%2C+S+A%3BChapman%2C+I&rft.aulast=Chin&rft.aufirst=N&rft.date=1989-08-01&rft.volume=84&rft.issue=8&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Vena caval penetration by gastric ulcer: massive hemorrhage and embolization of gastric contents to lungs. AN - 85205802; pmid-2760436 AB - A 54-year-old man who died from acute upper gastrointestinal blood loss was found on postmortem examination to have a large amount of blood in the intestinal lumen from perforation of a gastric ulcer into the inferior vena cava. Gastric contents had also embolized into the pulmonary circulation. Most of the stomach was located posteriorly in the right thoracic cavity because of prior esophageal surgery, which had brought the posterior wall of the stomach in apposition to the anterior wall of the inferior vena cava. This is thought to be the first report of a gastric ulcer forming a fistula into the inferior vena cava, with food embolization to the lung. JF - Journal of Clinical Gastroenterology AU - Palmer, R C AD - Gastroenterology Section, Veterans Administration Medical Center, Albuquerque, NM 87108. PY - 1989 SP - 455 EP - 457 VL - 11 IS - 4 SN - 0192-0790, 0192-0790 KW - Stomach Ulcer KW - Pulmonary Embolism KW - Food KW - Human KW - Peptic Ulcer Hemorrhage KW - Middle Age KW - Case Report KW - Peptic Ulcer Perforation KW - Pneumonia, Aspiration KW - Male KW - Vena Cava, Inferior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85205802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Vena+caval+penetration+by+gastric+ulcer%3A+massive+hemorrhage+and+embolization+of+gastric+contents+to+lungs.&rft.au=Palmer%2C+R+C&rft.aulast=Palmer&rft.aufirst=R&rft.date=1989-08-01&rft.volume=11&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Intestinal autointoxication: a medical leitmotif. AN - 85205630; pmid-2668399 AB - The idea that putrefaction of the stools causes disease, i.e., intestinal autointoxication, originated with physicians in ancient Egypt. They believed that a putrefactive principle associated with feces was absorbed in to the general circulation, where it acted to produce fever and pus. This description of the materia peccans represented the earliest forerunner of our present notion of endotoxin and its effect. The ancient Greeks extended the concept of putrefaction to involve not only the residues of food, but also those of bile, phlegm, and blood, incorporating it into their humoral theory of disease. During the 19th century, the early biochemical and bacteriologic studies lent credence to the idea of ptomaine poisoning--that degradation of protein in the colon by anerobic bacteria generated toxic amines. Among the leading proponents of autointoxication was Metchnikoff, who hypothesized that intestinal toxins shortened lifespan. The toxic process, however, was reversed by the consumption of lactic acid-producing bacteria that changed the colonic microflora and prevented proteolysis. The next logical step in treatment followed in the early 20th century when surgeons, chief among them Sir W. Arbuthnot Lane, performed colectomy to cure intestinal autointoxication. By the 1920s, the medical doctrine fell into disrepute as scientific advanced failed to give support. However, the idea persists in the public mind, probably as an extension of the childhood habit of toilet training. JF - Journal of Clinical Gastroenterology AU - Chen, T S AU - Chen, P S AD - Department of Pathology, East Orange Veterans Administration Medical Center, NJ 07019. PY - 1989 SP - 434 EP - 441 VL - 11 IS - 4 SN - 0192-0790, 0192-0790 KW - Egypt KW - Greece KW - Human KW - History of Medicine, 18th Cent. KW - Portraits KW - History of Medicine, 20th Cent. KW - History of Medicine, 19th Cent. KW - History of Medicine, Ancient KW - Toxins KW - Intestinal Absorption KW - Feces UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85205630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Intestinal+autointoxication%3A+a+medical+leitmotif.&rft.au=Chen%2C+T+S%3BChen%2C+P+S&rft.aulast=Chen&rft.aufirst=T&rft.date=1989-08-01&rft.volume=11&rft.issue=4&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Nonlinguistic auditory capabilities in aphasia. AN - 85143118; pmid-2475202 AB - Nonlinguistic auditory capabilities were assessed through psychophysical tests in 11 left-CVA aphasic, four right-CVA nonaphasic, and eight normal male subjects selected from the same age group. The tests included frequency discrimination, gap detection, gap discrimination, frequency sweep discrimination, assessment of the magnitude of the frequency uncertainty effect in the detectability of tones in noise, and assessment of frequency selectivity through simultaneous masked thresholds. Results of these tests were compared to measures of auditory comprehension obtained from the Boston Diagnostic Aphasia Examination, the Porch Index of Communicative Ability, and the Token Test. Nonlinguistic auditory performance of the three subject groups differed significantly from each other. For the left-CVA subjects, frequency sweep discrimination, frequency discrimination, and the frequency uncertainty effect in tone-in-noise detection were the best predictors of verbal auditory comprehension. The right-CVA subjects displayed marked deficits with regard to all pitch-related tests. The findings stress the importance of considering the presence of nonlinguistic auditory dysfunctions when evaluating linguistic auditory capabilities in aphasia. JF - Brain and Language AU - Divenyi, P L AU - Robinson, A J AD - Speech and Hearing Research Facility, Veterans Administration Medical Center, Martinez, California. PY - 1989 SP - 290 EP - 326 VL - 37 IS - 2 SN - 0093-934X, 0093-934X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85143118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Nonlinguistic+auditory+capabilities+in+aphasia.&rft.au=Divenyi%2C+P+L%3BRobinson%2C+A+J&rft.aulast=Divenyi&rft.aufirst=P&rft.date=1989-08-01&rft.volume=37&rft.issue=2&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Differential susceptibility to gentamicin ototoxicity between albino and pigmented guinea pigs. AN - 85142702; pmid-2793613 AB - The known chemical affinity of melanin pigment for aminoglycoside antibiotics has led to the suggestion that higher concentrations of these drugs will bind to the pigmented inner ear and produce greater ototoxicity compared to the nonpigmented albino cochlea. Although this has provided a compelling hypothesis, results from the few investigations to address this question have been equivocal. In the present study, cochlear microphonic (CM) thresholds were recorded from albino and pigmented guinea pigs both before and two weeks after exposure for 14 consecutive days to 100 mg/Kg gentamicin. Cochleae were dissected and half-turn segments prepared for surface examination of the organ of Corti. After gentamicin exposure, threshold shifts averaged a statistically reliable 33 dB in albinos and 19 dB for the pigmented animals. Anatomical studies revealed a significant 44% mean outer hair cell loss in albinos compared to a 21% loss in the pigmented inner ears. The results showed that albinos display greater ototoxicity from gentamicin than do pigmented guinea pigs. Aminoglycosides are known to exert toxicity through interaction with polyphosphoinositides found in high concentrations in the inner ear. Cochleae in both albino and pigmented animals appear to possess significant phospholipid concentrations and bind toxic levels of these drugs independent of inner ear pigment content. However, evidence showing that melanin can inhibit aminoglycoside activity in vitro suggests that, once these drugs bind to pigmented tissue, they may undergo inactivation in a manner unavailable to the nonpigmented albino cochlea. The present results are consistent with the possibility that cochlear melanin may inhibit gentamicin activity in vivo and decrease the severity of aminoglycoside ototoxicity in the pigmented inner ear. JF - Hearing Research AU - Conlee, J W AU - Gill, S S AU - McCandless, P T AU - Creel, D J AD - Veterans Administration Medical Center, Salt Lake City, Utah. PY - 1989 SP - 43 EP - 51 VL - 41 IS - 1 SN - 0378-5955, 0378-5955 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85142702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+Research&rft.atitle=Differential+susceptibility+to+gentamicin+ototoxicity+between+albino+and+pigmented+guinea+pigs.&rft.au=Conlee%2C+J+W%3BGill%2C+S+S%3BMcCandless%2C+P+T%3BCreel%2C+D+J&rft.aulast=Conlee&rft.aufirst=J&rft.date=1989-08-01&rft.volume=41&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Hearing+Research&rft.issn=03785955&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Sequential loss of splenic and then hepatic function in a patient with Thorotrast loading. AN - 79277731; 2805550 JF - Clinical nuclear medicine AU - Antar, M A AU - Kassamali, H AU - Spencer, R P AD - Department of Nuclear Medicine, Veterans Administration Medical Center, Newington, Connecticut. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 634 EP - 635 VL - 14 IS - 8 SN - 0363-9762, 0363-9762 KW - Thorium Dioxide KW - 9XA7X17UQC KW - Index Medicus KW - Humans KW - Adult KW - Female KW - Radionuclide Imaging KW - Spleen -- diagnostic imaging KW - Liver -- physiopathology KW - Thorium Dioxide -- adverse effects KW - Spleen -- physiopathology KW - Liver -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79277731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=Sequential+loss+of+splenic+and+then+hepatic+function+in+a+patient+with+Thorotrast+loading.&rft.au=Antar%2C+M+A%3BKassamali%2C+H%3BSpencer%2C+R+P&rft.aulast=Antar&rft.aufirst=M&rft.date=1989-08-01&rft.volume=14&rft.issue=8&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-12 N1 - Date created - 1989-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunotoxicity of blood-synthetic membrane interactions. AN - 79229447; 2676673 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Henderson, L W AD - Veterans Administration Medical Center, San Diego, California. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 228 EP - 234 VL - 13 IS - 2 SN - 0272-0590, 0272-0590 KW - Membranes, Artificial KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Immunity -- drug effects KW - Blood -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79229447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Immunotoxicity+of+blood-synthetic+membrane+interactions.&rft.au=Henderson%2C+L+W&rft.aulast=Henderson&rft.aufirst=L&rft.date=1989-08-01&rft.volume=13&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-28 N1 - Date created - 1989-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monotherapy of stable angina with nicardipine hydrochloride: double-blind, placebo-controlled, randomized study. AN - 79229142; 2792112 AB - The effect of nicardipine hydrochloride, a calcium-channel blocking agent, was studied in 46 patients with stable angina in a double-blind, placebo-controlled, randomized, repeated cross-over protocol, using a 30 or 40 mg dose of nicardipine or placebo three times a day. Mean resting heart rate and blood pressure did not change significantly with 30 mg nicardipine; heart rate increased from 81 +/- 10 to 88 +/- 13 beats min-1, systolic blood pressure decreased from 129 +/- 18 to 119 +/- 16 mmHg, and diastolic blood pressure from 81 +/- 12 to 74 +/- 11 mmHg (P less than 0.01 for all three variables) with a 40 mg dose. Using a treadmill exercise protocol, mean exercise duration increased from 5.4 +/- 1.8 to 6.0 +/- 1.8 min (P less than 0.01) with 30 mg nicardipine, and from 5.8 +/- 1.7 to 6.6 +/- 1.9 min (P less than 0.01) with 40 mg. Time to onset of angina increased from 4.6 +/- 1.9 to 5.2 +/- 1.7 min (P less than 0.05) with 30 mg and from 5.1 +/- 1.8 to 5.7 +/- 1.8 min (P = NS) with 40 mg. Mean anginal frequency and sublingual nitroglycerin consumption were low during the cross-over placebo period and did not change significantly during therapy with nicardipine. Non-cardiac side-effects were mild and required the withdrawal of only one patient from the study. However, during nicardipine therapy four patients had unstable angina and two developed a non-Q wave myocardial infarction. Of these patients, five were receiving a beta-adrenergic blocker that was discontinued prior to the study.(ABSTRACT TRUNCATED AT 250 WORDS) JF - European heart journal AU - Gheorghiade, M AU - Weiner, D A AU - Chakko, S AU - Lessem, J N AU - Klein, M D AD - Veterans Administration Medical Center, Salem, Virginia. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 695 EP - 701 VL - 10 IS - 8 SN - 0195-668X, 0195-668X KW - Nicardipine KW - CZ5312222S KW - Index Medicus KW - Exercise Test KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Electrocardiography KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Blood Pressure -- drug effects KW - Angina Pectoris -- drug therapy KW - Nicardipine -- adverse effects KW - Nicardipine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79229142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+heart+journal&rft.atitle=Monotherapy+of+stable+angina+with+nicardipine+hydrochloride%3A+double-blind%2C+placebo-controlled%2C+randomized+study.&rft.au=Gheorghiade%2C+M%3BWeiner%2C+D+A%3BChakko%2C+S%3BLessem%2C+J+N%3BKlein%2C+M+D&rft.aulast=Gheorghiade&rft.aufirst=M&rft.date=1989-08-01&rft.volume=10&rft.issue=8&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=European+heart+journal&rft.issn=0195668X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-06 N1 - Date created - 1989-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein C activity levels in endotoxin-induced disseminated intravascular coagulation in a dog model. AN - 79211000; 2781530 AB - The levels of protein C (PC) and other coagulation factors were monitored during endotoxin-induced disseminated intravascular coagulation (DIC) in the dog. Initial evaluation of the effectiveness of intradermal administration of bolus endotoxin quantities into the dog, demonstrated induction of DIC in the canine, without the severe side effects associated with bacterial sepsis. Quantitative determination of canine plasma protein C levels were performed using a multiple step amidolytic assay, that included a specific precipitation of the vitamin K-dependent proteins from citrated plasma, followed by thrombin activation (and neutralization) and subsequent measurement of the activated protein C (APC) by chromogen hydrolysis. This investigation demonstrated, that over a twenty-four hour interval, intradermal administration of endotoxin produces a gradual decrease in the PC activity levels, concomitant with a significant reduction in the Factor V, Factor VIII and fibrinogen levels and platelet count, and a prolongation of the Prothrombin Time and Partial Thromboplastin Time. During the first 6 hours, protein C levels fell below the pre-levels and remained significantly lower in the surviving dogs. Thus, this endotoxin-induced DIC animal model permits evaluation of various hemostatic parameters, yet diminishes the severe clinical findings associated with DIC. JF - Thrombosis research AU - Madden, R M AU - Ward, M AU - Marlar, R A AD - Laboratory Service, Veterans Administration Medical Center, Denver, CO. Y1 - 1989/08/01/ PY - 1989 DA - 1989 Aug 01 SP - 297 EP - 307 VL - 55 IS - 3 SN - 0049-3848, 0049-3848 KW - Blood Coagulation Factors KW - 0 KW - Endotoxins KW - Protein C KW - Index Medicus KW - Hematologic Tests KW - Animals KW - Dogs KW - Disease Models, Animal KW - Blood Coagulation Factors -- analysis KW - Male KW - Protein C -- metabolism KW - Disseminated Intravascular Coagulation -- blood KW - Endotoxins -- administration & dosage KW - Endotoxins -- blood KW - Disseminated Intravascular Coagulation -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79211000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thrombosis+research&rft.atitle=Protein+C+activity+levels+in+endotoxin-induced+disseminated+intravascular+coagulation+in+a+dog+model.&rft.au=Madden%2C+R+M%3BWard%2C+M%3BMarlar%2C+R+A&rft.aulast=Madden&rft.aufirst=R&rft.date=1989-08-01&rft.volume=55&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Thrombosis+research&rft.issn=00493848&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-16 N1 - Date created - 1989-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of drug-drug interactions among nursing home residents. AN - 79200366; 2773961 AB - The extent of clinically important drug-drug interactions in the patient population of a nursing home was studied. The administration of medications to all 138 residents of two wards of the hospital-affiliated facility was monitored for 15 days through a review of nurses' medication-administration records and patients' charts. Information on the nature and timing of administered drug combinations was compared with published information to identify potential drug interactions. If a serious drug interaction was suspected, the recorded information was verified through the nurse in charge of that patient. Few of the drug interactions commonly reported to occur in nursing homes were observed at the facility, where drug therapy is monitored by a team of geriatric practitioners that includes two pharmacists. Of the 24 suspected interactions that were identified, 11 had potential clinical importance, and all 11 involved drug combinations that could alter the metabolism or action of one of the drugs. However, only two patients were exposed to any substantial degree of risk, and dosages of the drugs involved were adjusted. An additional 13 patients were taking a combination of drugs that could have altered the intestinal absorption of one of the drugs. Careful timing of drug administration avoided this potential problem. With proper education of the nursing staff, immediate clarification of medication orders, and optimal timing of drug administration, many clinically important drug-drug and drug-food interactions can be avoided in nursing home patients. JF - American journal of hospital pharmacy AU - Tamai, I Y AU - Strome, L S AU - Marshall, C E AU - Mooradian, A D AD - Sepulveda Veterans Administration Medical Center, California. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1567 EP - 1569 VL - 46 IS - 8 SN - 0002-9289, 0002-9289 KW - Index Medicus KW - California KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Pharmacokinetics KW - Male KW - Female KW - Drug Interactions KW - Nursing Homes -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79200366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hospital+pharmacy&rft.atitle=Analysis+of+drug-drug+interactions+among+nursing+home+residents.&rft.au=Tamai%2C+I+Y%3BStrome%2C+L+S%3BMarshall%2C+C+E%3BMooradian%2C+A+D&rft.aulast=Tamai&rft.aufirst=I&rft.date=1989-08-01&rft.volume=46&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hospital+pharmacy&rft.issn=00029289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-03 N1 - Date created - 1989-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The quantities of nutrients recommended by the NRC abate the effects of a toxic alcohol dose administered to rats. AN - 79199431; 2778548 JF - The Journal of nutrition AU - Derr, R F AD - Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1228 EP - 1230 VL - 119 IS - 8 SN - 0022-3166, 0022-3166 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Nutritional Requirements KW - Animals KW - Male KW - Female KW - Pregnancy KW - Ethanol -- blood KW - Animal Nutritional Physiological Phenomena KW - Ethanol -- toxicity KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=The+quantities+of+nutrients+recommended+by+the+NRC+abate+the+effects+of+a+toxic+alcohol+dose+administered+to+rats.&rft.au=Derr%2C+R+F&rft.aulast=Derr&rft.aufirst=R&rft.date=1989-08-01&rft.volume=119&rft.issue=8&rft.spage=1228&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Nutr. 1989 Dec;119(12):2038-40 [2621495] Erratum In: J Nutr 1989 Nov;119(11):1761 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trace minerals and the kidney: an overview. AN - 79196888; 2674254 AB - The deviations from normal health produced by abnormalities in trace mineral metabolism in patients with renal disease and renal disorders produced by deficiencies or excesses of these trace minerals serve as the focus for this symposium on trace minerals and the kidney. Zinc, the trace mineral of most interest of the nephrologist, and aluminum, the nonessential (toxic) trace element of most interest, are treated in separate reviews. Iron, copper, selenium, and silicon (essential trace elements) and cadmium, lead, mercury, and lithium (nonessential or toxic elements) are covered in this review. JF - Journal of the American College of Nutrition AU - Lindeman, R D AD - Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 285 EP - 291 VL - 8 IS - 4 SN - 0731-5724, 0731-5724 KW - Trace Elements KW - 0 KW - Index Medicus KW - Humans KW - Kidney -- metabolism KW - Trace Elements -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79196888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Nutrition&rft.atitle=Trace+minerals+and+the+kidney%3A+an+overview.&rft.au=Lindeman%2C+R+D&rft.aulast=Lindeman&rft.aufirst=R&rft.date=1989-08-01&rft.volume=8&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Nutrition&rft.issn=07315724&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. AN - 79166990; 2788422 AB - Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxy-adenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-osseous dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model. JF - Arthritis and rheumatism AU - Wortmann, R L AU - Veum, J A AU - Ryan, L M AU - Cheung, H S AD - Department of Internal Medicine, Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1014 EP - 1021 VL - 32 IS - 8 SN - 0004-3591, 0004-3591 KW - Adenosine Deaminase Inhibitors KW - 0 KW - Deoxyadenosines KW - Purines KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Nucleoside Deaminases KW - EC 3.5.4.- KW - Adenosine Deaminase KW - EC 3.5.4.4 KW - Abridged Index Medicus KW - Index Medicus KW - Purines -- metabolism KW - Animals KW - Adenosine Triphosphate -- physiology KW - Cell Survival -- drug effects KW - Bone and Bones -- pathology KW - Disease Models, Animal KW - Rabbits KW - Adenosine Triphosphate -- pharmacology KW - Adenosine Deaminase -- deficiency KW - Cartilage -- pathology KW - Cartilage -- drug effects KW - Nucleoside Deaminases -- deficiency KW - Deoxyadenosines -- toxicity KW - Deoxyadenosines -- metabolism KW - Cartilage -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79166990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Differential+deoxyadenosine+toxicity+to+immature+rabbit+cartilage+in+vitro.+A+model+for+the+chondro-osseous+dysplasia+of+adenosine+deaminase+deficiency.&rft.au=Wortmann%2C+R+L%3BVeum%2C+J+A%3BRyan%2C+L+M%3BCheung%2C+H+S&rft.aulast=Wortmann&rft.aufirst=R&rft.date=1989-08-01&rft.volume=32&rft.issue=8&rft.spage=1014&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-14 N1 - Date created - 1989-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Palliative hemibody irradiation in hormonally refractory metastatic prostate cancer. AN - 79165066; 2474883 AB - Ten patients with hormonally refractory symptomatic metastatic prostate carcinoma underwent palliative hemibody irradiation (HBI). Four of the patients also had had previous irradiation to symptomatic focal sites. Two of the patients underwent upper body HBI with 5 Gy, while 6 patients underwent lower body HBI with 7 Gy. Two patients received sequential lower body HBI followed by upper body HBI. All 10 patients reported subjective pain relief within the immediate forty-eight to ninety-six hours following therapy. The average response lasted four months. Therefore the majority of our patients achieved symptomatic pain relief for the remainder of their lives which averaged five months (range 1.5-12 months). All 10 patients suffered transient but clinically insignificant hematologic toxicity. There was no death or other significant morbidity attributable to the treatment. We conclude that HBI is safe and effective palliation of bone pain in patients who have failed conventional therapy for prostate cancer. JF - Urology AU - Nseyo, U O AU - Fontanesi, J AU - Naftulin, B N AD - Urology Section, Veterans Administration Medical Center, Martinez, California. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 76 EP - 79 VL - 34 IS - 2 SN - 0090-4295, 0090-4295 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Evaluation Studies as Topic KW - Diethylstilbestrol -- therapeutic use KW - Combined Modality Therapy KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Bone Neoplasms -- secondary KW - Orchiectomy KW - Prostatic Neoplasms -- pathology KW - Pain, Intractable -- radiotherapy KW - Prostatic Neoplasms -- physiopathology KW - Prostatic Neoplasms -- therapy KW - Palliative Care -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79165066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Palliative+hemibody+irradiation+in+hormonally+refractory+metastatic+prostate+cancer.&rft.au=Nseyo%2C+U+O%3BFontanesi%2C+J%3BNaftulin%2C+B+N&rft.aulast=Nseyo&rft.aufirst=U&rft.date=1989-08-01&rft.volume=34&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=00904295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-15 N1 - Date created - 1989-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polysomnographic assessment of DIMS: empirical evaluation of its diagnostic value. AN - 79157728; 2762687 AB - This investigation examined the diagnostic value of polysomnography (PSG) for evaluating disorders of initiating and maintaining sleep (DIMS). The sample consisted of 100 outpatients who presented to the Duke Sleep Disorders Center with a complaint of chronic insomnia. All patients were given comprehensive medical, psychiatric, behavioral, and ambulatory PSG evaluations. Sleep disorder diagnoses were assigned using the criteria of the Association of Sleep Disorders Centers. Overall, PSG yielded important diagnostic information in 65% of the sample: 34% were given a primary sleep disorder diagnosis that was heavily dependent on PSG data [periodic movements of sleep (PMS) = 25%, apnea = 3%, and subjective insomnia = 6%]; 15% were given a secondary diagnosis of one of these three disorders; and PSG ruled out suspected PMS in 9% and sleep apnea in 7% of the sample. Patients greater than 40 years of age had a significantly higher rate of positive PSG findings than younger patients. Using only the clinical exam, two experienced sleep clinicians were able to predict only 14 of 25 PMS cases and one of three cases of sleep apnea. Based on these data, we suggest using PSG routinely with older insomniacs and with younger patients who fail initial treatment. JF - Sleep AU - Edinger, J D AU - Hoelscher, T J AU - Webb, M D AU - Marsh, G R AU - Radtke, R A AU - Erwin, C W AD - Veterans Administration Medical Center, Durham, NC 27705. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 315 EP - 322 VL - 12 IS - 4 SN - 0161-8105, 0161-8105 KW - Index Medicus KW - Arousal KW - Aged, 80 and over KW - Signal Processing, Computer-Assisted -- instrumentation KW - Humans KW - Adult KW - Aged KW - Substance-Related Disorders -- complications KW - Middle Aged KW - Mental Disorders -- complications KW - Alcoholism -- complications KW - Male KW - Female KW - Monitoring, Physiologic -- instrumentation KW - Sleep Initiation and Maintenance Disorders -- diagnosis KW - Sleep Apnea Syndromes -- diagnosis KW - Electroencephalography -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sleep&rft.atitle=Polysomnographic+assessment+of+DIMS%3A+empirical+evaluation+of+its+diagnostic+value.&rft.au=Edinger%2C+J+D%3BHoelscher%2C+T+J%3BWebb%2C+M+D%3BMarsh%2C+G+R%3BRadtke%2C+R+A%3BErwin%2C+C+W&rft.aulast=Edinger&rft.aufirst=J&rft.date=1989-08-01&rft.volume=12&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Sleep&rft.issn=01618105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-20 N1 - Date created - 1989-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mild nephrotoxicity associated with vancomycin use. AN - 79155761; 2764651 AB - Nephrotoxicity related to vancomycin hydrochloride therapy has been reported at overall rates of 7% to 16% and as high as 35% when combined with an aminoglycoside antibiotic. We conducted a prospective study in older men. A group that received vancomycin was compared with a control group to determine the incidence of nephrotoxicity secondary to vancomycin therapy alone and in combination with aminoglycosides, to identify possible risk factors associated with nephrotoxicity, and to determine the incidence of other adverse effects associated with vancomycin use. Nephrotoxicity occurred in 11 (17%) of 66 patients receiving vancomycin and in 3 (5%) of 57 controls overall. Stepwise logistic-regression analysis failed to identify underlying illnesses or concurrent risks that may have contributed to the development of nephrotoxicity associated with vancomycin. Adverse effects, including phlebitis (14%), neutropenia (1%), rash (0%), and red neck syndrome (0%), occurred at rates similar to previous reports. JF - Archives of internal medicine AU - Downs, N J AU - Neihart, R E AU - Dolezal, J M AU - Hodges, G R AD - Medical Service, Veterans Administration Medical Center, Kansas City, MO 64128. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1777 EP - 1781 VL - 149 IS - 8 SN - 0003-9926, 0003-9926 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Vancomycin KW - 6Q205EH1VU KW - Creatinine KW - AYI8EX34EU KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Infusions, Intravenous KW - Phlebitis -- chemically induced KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Aged KW - Neutropenia -- chemically induced KW - Creatinine -- blood KW - Drug Therapy, Combination KW - Risk Factors KW - Anti-Bacterial Agents -- administration & dosage KW - Middle Aged KW - Male KW - Vancomycin -- toxicity KW - Vancomycin -- administration & dosage KW - Kidney -- drug effects KW - Vancomycin -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79155761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Mild+nephrotoxicity+associated+with+vancomycin+use.&rft.au=Downs%2C+N+J%3BNeihart%2C+R+E%3BDolezal%2C+J+M%3BHodges%2C+G+R&rft.aulast=Downs&rft.aufirst=N&rft.date=1989-08-01&rft.volume=149&rft.issue=8&rft.spage=1777&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seizure propensity with imipenem. AN - 79155461; 2669668 AB - Five patients with seizures related to imipenem administration are described. The potential of imipenem therapy to cause seizure was further studied in a mouse model and compared with the potential for seizure with penicillin and cefotaxime therapy. Penicillin caused ataxia and seizure at a mean mouse serum level of 5800 microns/mL, cefotaxime at 3400 microns/mL, and imipenem at a much lower serum concentration of 1900 microns/mL. The potent activity of imipenem therapy against bacteria, allowing for a clinical dose of only 2 g/d, is unfortunately offset by its higher propensity to induce neurologic symptoms in humans and mice at much smaller doses than would therapy with penicillin G or the cephalosporins, such as cefotaxime. JF - Archives of internal medicine AU - Eng, R H AU - Munsif, A N AU - Yangco, B G AU - Smith, S M AU - Chmel, H AD - Medical Service, Veterans Administration Medical Center, East Orange, NJ 07019. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 1881 EP - 1883 VL - 149 IS - 8 SN - 0003-9926, 0003-9926 KW - Imipenem KW - 71OTZ9ZE0A KW - Cefotaxime KW - N2GI8B1GK7 KW - Penicillin G KW - Q42T66VG0C KW - Abridged Index Medicus KW - Index Medicus KW - Multicenter Studies as Topic KW - Animals KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Mice KW - Male KW - Female KW - Seizures -- chemically induced KW - Cefotaxime -- administration & dosage KW - Penicillin G -- toxicity KW - Imipenem -- toxicity KW - Imipenem -- adverse effects KW - Penicillin G -- adverse effects KW - Cefotaxime -- adverse effects KW - Imipenem -- administration & dosage KW - Penicillin G -- administration & dosage KW - Cefotaxime -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79155461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Seizure+propensity+with+imipenem.&rft.au=Eng%2C+R+H%3BMunsif%2C+A+N%3BYangco%2C+B+G%3BSmith%2C+S+M%3BChmel%2C+H&rft.aulast=Eng&rft.aufirst=R&rft.date=1989-08-01&rft.volume=149&rft.issue=8&rft.spage=1881&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1990 Jul;150(7):1551 [2369261] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. AN - 79153748; 2669155 AB - Nineteen men with mild to moderate hypertension and without a history of cardiac arrhythmias were randomized (double-blind) into groups to receive hydrochlorothiazide (HCTZ) at a dose of 25 mg/day, HCTZ at 50 mg/day, or HCTZ (25 mg) plus triamterene (50 mg) for a six-month period after a three-week (single-blind) placebo period. Serum electrolyte values were determined at baseline and at frequent intervals thereafter. Twenty-four hour ambulatory electrocardiograms were obtained at baseline and just before study termination. Mild hypokalemia (less than 3.5 mEq/L) occurred in approximately half of the patients and was unrelated to treatment group. Serious arrhythmias were infrequent, though some patients had large numbers of extra beats. The incidence of arrhythmia appeared unrelated to serum potassium concentration. We conclude that mild hypokalemia associated with low-dose diuretic therapy for hypertension is not arrhythmogenic. JF - Southern medical journal AU - Peters, R W AU - Hamilton, J AU - Hamilton, B P AD - Medical Service, Veterans Administration Medical Center, Baltimore, MD 21218. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 966 EP - 9, 976 VL - 82 IS - 8 SN - 0038-4348, 0038-4348 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Triamterene KW - WS821Z52LQ KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Electrocardiography KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Monitoring, Physiologic KW - Male KW - Triamterene -- administration & dosage KW - Hydrochlorothiazide -- administration & dosage KW - Hypokalemia -- chemically induced KW - Arrhythmias, Cardiac -- etiology KW - Hypokalemia -- complications KW - Triamterene -- adverse effects KW - Hypertension -- drug therapy KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79153748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Incidence+of+cardiac+arrhythmias+associated+with+mild+hypokalemia+induced+by+low-dose+diuretic+therapy+for+hypertension.&rft.au=Peters%2C+R+W%3BHamilton%2C+J%3BHamilton%2C+B+P&rft.aulast=Peters&rft.aufirst=R&rft.date=1989-08-01&rft.volume=82&rft.issue=8&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-13 N1 - Date created - 1989-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Severe myocarditis following high-dose interleukin-2 administration. AN - 79141708; 2787976 AB - We observed a patient who developed unusually severe myocardial dysfunction during therapy for renal cell carcinoma with high-dose interleukin-2 (IL-2). Although cardiac isoenzymes became markedly elevated shortly after the completion of 14 doses of IL-2 (100,000 U/kg of IL-2 every eight hours), serial electrocardiograms revealed only nonspecific changes. Echocardiography documented diffuse myocardial dysfunction, with akinesis of the anteroseptal region, suggestive of myocardial infarction. This anteroseptal hypokinesis persisted over a five-day period. The patient died unexpectedly and postmortem evaluation of the heart revealed a severe, diffuse lymphocytic, and eosinophilic myocarditis with myocyte necrosis, especially prominent in the anteroseptal region. This is the first histologically confirmed case of myocarditis reported, to our knowledge, in association with IL-2 therapy for cancer. JF - Archives of pathology & laboratory medicine AU - Samlowski, W E AU - Ward, J H AU - Craven, C M AU - Freedman, R A AD - Salt Lake City Veterans Administration Medical Center, UT. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 838 EP - 841 VL - 113 IS - 8 SN - 0003-9985, 0003-9985 KW - Interleukin-2 KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Kidney Neoplasms -- drug therapy KW - Drug Administration Schedule KW - Myocardium -- pathology KW - Humans KW - Middle Aged KW - Carcinoma, Renal Cell -- drug therapy KW - Female KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Myocarditis -- pathology KW - Myocarditis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79141708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=Severe+myocarditis+following+high-dose+interleukin-2+administration.&rft.au=Samlowski%2C+W+E%3BWard%2C+J+H%3BCraven%2C+C+M%3BFreedman%2C+R+A&rft.aulast=Samlowski&rft.aufirst=W&rft.date=1989-08-01&rft.volume=113&rft.issue=8&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=00039985&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-30 N1 - Date created - 1989-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Replicated factor structure of the Beck Depression Inventory. AN - 79128649; 2760598 AB - The factor structure of the Beck Depression Inventory (BDI) was examined in an initial sample of 407 patients and replicated in a sample of 370 patients, using principal components analysis and varimax rotation. The entire sample was 98% male, with ages ranging from 22 to 88 years. The incidence of alcoholism was 72%, and the incidence of major mental illnesses was 17%. The stable dominant first factor (cognitive) accounted for 67 to 81% of the common variance, with a correlation of .94 between the factor loadings in the initial and replication analyses. The unstable second factor (vegetative) accounted for 15% to 19% of the common variance, with a correlation of .58 in item loadings. Consequently, the BDI appears to measure the cognitive aspects of depressive severity in a global fashion, as Beck originally intended. Approximately half of the items contribute very little useful predictive information. The fact that BDI total scores are not strongly related to the traditional vegetative symptoms of depression used in psychiatry is an artifact of the original method used to construct the test and is not a statement about the fundamental characteristics of depression. JF - The Journal of nervous and mental disease AU - Louks, J AU - Hayne, C AU - Smith, J AD - Psychology Service, Veterans Administration Domiciliary, White City, Oregon 97503. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 473 EP - 479 VL - 177 IS - 8 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Alcoholism -- psychology KW - Male KW - Female KW - Cognition KW - Factor Analysis, Statistical KW - Personality Inventory KW - Depression -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79128649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Replicated+factor+structure+of+the+Beck+Depression+Inventory.&rft.au=Louks%2C+J%3BHayne%2C+C%3BSmith%2C+J&rft.aulast=Louks&rft.aufirst=J&rft.date=1989-08-01&rft.volume=177&rft.issue=8&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-08 N1 - Date created - 1989-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug-induced illness in the elderly. AN - 79118765; 2666970 AB - The elderly are predisposed to adverse drug reactions because of age-related physiologic changes, interaction of one drug with another, and interaction between a drug and a coexisting medical condition. Recognition of such adverse reactions is essential, because many are reversible and many are even preventable. Assessment of clinical disorders in the elderly should include evaluation of drugs as a causal or aggravating factor. Careful choice and dosage of drugs in the elderly will minimize the likelihood of drug-induced illness. JF - Postgraduate medicine AU - Harper, C M AU - Newton, P A AU - Walsh, J R AD - Veterans Administration Medical Center, Portland. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 245 EP - 256 VL - 86 IS - 2 SN - 0032-5481, 0032-5481 KW - Abridged Index Medicus KW - Index Medicus KW - Aging -- physiology KW - Drug Interactions KW - Confusion -- etiology KW - Depression -- etiology KW - Humans KW - Aged KW - Chronic Disease KW - Urinary Incontinence -- chemically induced KW - Pharmacokinetics KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79118765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Drug-induced+illness+in+the+elderly.&rft.au=Harper%2C+C+M%3BNewton%2C+P+A%3BWalsh%2C+J+R&rft.aulast=Harper&rft.aufirst=C&rft.date=1989-08-01&rft.volume=86&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Postgrad Med. 1990 Mar;87(4):33-4, 37 [2315255] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An evaluation of the toxicity of carbon fiber composites for lung cells in vitro and in vivo. AN - 79117356; 2753009 AB - Carbon fiber composite materials are used in a variety of applications in industries, and machining processes often generate aerosols of these materials in the workplace. Because the potential health effects of these particles are uncertain, we evaluated the toxicity of a series of carbon fiber composites in vitro using rabbit alveolar macrophages and in vivo using direct intratracheal injection into rat lungs. For comparison, we studied two reference materials, Al2O3 and alpha-quartz, which are inert and toxic, respectively. We measured cytotoxicity in vitro for rabbit alveolar macrophages by trypan blue exclusion and by the release of 51Cr from prelabeled macrophages. We also injected the samples intratracheally into specific pathogen-free rats and 1 month later lavaged the lungs to recover airway cells and fluid. In each of the assays, the quartz was the most toxic substance tested, causing marked cytotoxicity for alveolar macrophages and large increases in airway cells and neutrophils in the rat lungs, whereas the Al2O3 was consistently the least toxic. Three of the composite samples consistently showed little toxicity, whereas two were consistently toxic for alveolar macrophages and caused significant accumulations of airway cells and neutrophils in the rat lungs. The results of the in vitro and in vivo studies produced a similar ranking of toxicity for all of the samples. These studies show that in vitro and in vivo testing is a useful approach to the evaluation of the potential biologic effects of new materials in the lungs. Although these carbon fiber composites appear to be much less toxic than quartz, the data suggest that two of the composites are not inert. Exposure limits more strict than those for nuisance dusts should be used in the workplace for these two composites. Longer term inhalation exposure studies using these two composites are warranted in order to better define their effects in the lungs. JF - Environmental research AU - Martin, T R AU - Meyer, S W AU - Luchtel, D R AD - Medical Research Service, Seattle Veterans Administration Medical Center, Washington 98108. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 246 EP - 261 VL - 49 IS - 2 SN - 0013-9351, 0013-9351 KW - Epoxy Compounds KW - 0 KW - Ethers, Cyclic KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Rats KW - Macrophages -- cytology KW - Animals KW - Reference Values KW - Cell Survival -- drug effects KW - Body Weight -- drug effects KW - Macrophages -- physiology KW - Rabbits KW - Phagocytosis -- drug effects KW - Macrophages -- drug effects KW - Male KW - Carbon -- pharmacology KW - Ethers, Cyclic -- toxicity KW - Epoxy Compounds -- pharmacology KW - Lung -- drug effects KW - Epoxy Compounds -- toxicity KW - Lung -- pathology KW - Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79117356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=An+evaluation+of+the+toxicity+of+carbon+fiber+composites+for+lung+cells+in+vitro+and+in+vivo.&rft.au=Martin%2C+T+R%3BMeyer%2C+S+W%3BLuchtel%2C+D+R&rft.aulast=Martin&rft.aufirst=T&rft.date=1989-08-01&rft.volume=49&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-29 N1 - Date created - 1989-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol. AN - 79093894; 2501140 AB - The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. The venoconstriction was greater in the lesion than in the nonlesion area. Intragastric pretreatment with either BW755C, a lipoxygenase inhibitor, or Rioprostil, a synthetic prostaglandin E1 analogue, significantly inhibited both the ethanol-induced venoconstriction and the gross lesion formation. In contrast, pretreatment by the submucosal application of either BW755C (50 micrograms/ml) or Rioprostil (50-500 ng/ml) had no effect on either the submucosal venoconstriction or the mucosal lesion formation. In conclusion, leukotrienes released from the gastric mucosa appear to be involved in the ethanol-induced submucosal venoconstriction associated with gastric mucosal injury. Prostaglandin pretreatment protects against this venoconstriction and gross lesion by a mucosal effect but not by a direct effect on submucosal venules. JF - Gastroenterology AU - Yonei, Y AU - Guth, P H AD - Medical Service, Veterans Administration Medical Center, West Los Angeles, California. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 304 EP - 312 VL - 97 IS - 2 SN - 0016-5085, 0016-5085 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anti-Ulcer Agents KW - Leukotrienes KW - Prostaglandins E KW - Prostaglandins, Synthetic KW - Pyrazoles KW - Ethanol KW - 3K9958V90M KW - 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine KW - 66000-40-6 KW - Rioprostil KW - 7JL402PVQR KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Anti-Ulcer Agents -- pharmacology KW - Regional Blood Flow KW - Rats KW - Rats, Inbred Strains KW - Pyrazoles -- pharmacology KW - Prostaglandins, Synthetic -- pharmacology KW - Prostaglandins E -- pharmacology KW - Premedication KW - Vasoconstriction -- drug effects KW - Time Factors KW - Male KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Leukotrienes -- physiology KW - Gastric Mucosa -- blood supply KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79093894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Lipoxygenase+metabolites+in+the+rat+gastric+microvascular+response+to+intragastric+ethanol.&rft.au=Yonei%2C+Y%3BGuth%2C+P+H&rft.aulast=Yonei&rft.aufirst=Y&rft.date=1989-08-01&rft.volume=97&rft.issue=2&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-18 N1 - Date created - 1989-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Tumor lysis syndrome in nonhematopoietic neoplasms. AN - 79085610; 2472863 AB - A 57-year-old woman developed severe tumor lysis syndrome characterized by acute hyperuricemic nephropathy, hyperphosphatemia, hyperkalemia, and hypocalcemia after therapy with cyclophosphamide, methotrexate, and 5-fluorouracil for metastatic infiltrating ductal carcinoma of the breast involving the chest wall, lungs, pleurae, and liver. Similar metabolic derangements developed in a 58-year-old man after therapy with vinblastine and bleomycin for classical seminoma with widespread, bulky lymph node metastases. Both patients died of infection associated with granulocytopenia within 2 weeks after the initiation of chemotherapy despite significant improvement in the manifestations of tumor lysis syndrome. At autopsy, there was anatomic evidence of extensive tumor necrosis in each case. The pathogenesis of this problem in the present cases is discussed, and this unusual complication of the treatment of nonhematopoietic malignancies is reviewed. JF - Cancer AU - Barton, J C AD - Department of Medicine, Veterans Administration Medical Center, Birmingham, Alabama. Y1 - 1989/08/01/ PY - 1989 DA - 1989 Aug 01 SP - 738 EP - 740 VL - 64 IS - 3 SN - 0008-543X, 0008-543X KW - Bleomycin KW - 11056-06-7 KW - Vinblastine KW - 5V9KLZ54CY KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Abridged Index Medicus KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Bleomycin -- administration & dosage KW - Lymphatic Metastasis KW - Humans KW - Cisplatin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Testicular Neoplasms -- drug therapy KW - Dysgerminoma -- drug therapy KW - Vinblastine -- administration & dosage KW - Middle Aged KW - Dysgerminoma -- secondary KW - Methotrexate -- administration & dosage KW - Carcinoma, Intraductal, Noninfiltrating -- drug therapy KW - Female KW - Male KW - Tumor Lysis Syndrome -- etiology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79085610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Tumor+lysis+syndrome+in+nonhematopoietic+neoplasms.&rft.au=Barton%2C+J+C&rft.aulast=Barton&rft.aufirst=J&rft.date=1989-08-01&rft.volume=64&rft.issue=3&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potassium advances circadian activity rhythms: interactions with lithium. AN - 79105234; 2752303 AB - Lithium delays the circadian rhythm of wheel-running in Syrian hamsters at plasma concentrations (0.59-0.74 mM) that also cause toxic weight loss. A moderate elevation of dietary potassium (up to 6 times normal intake) prevented lithium-induced weight loss in a dose-dependent manner, but had no effect on the delay of activity rhythms caused by lithium. Without lithium, the highest level of potassium intake advanced activity rhythms by 1 h relative to an entraining light:dark cycle. These results suggest that lithium's toxic, but not behavioral, actions involve an interaction with potassium ion. Furthermore, dietary potassium supplementation might have independent uses as treatment for chronobiological disorders. JF - Brain research AU - Klemfuss, H AU - Kripke, D F AD - Department of Psychiatry (V-116A), Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1989/07/17/ PY - 1989 DA - 1989 Jul 17 SP - 300 EP - 304 VL - 492 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Lithium KW - 9FN79X2M3F KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Body Weight KW - Animals KW - Diet KW - Male KW - Cricetinae -- physiology KW - Circadian Rhythm -- drug effects KW - Potassium -- pharmacology KW - Motor Activity -- drug effects KW - Lithium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79105234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Potassium+advances+circadian+activity+rhythms%3A+interactions+with+lithium.&rft.au=Klemfuss%2C+H%3BKripke%2C+D+F&rft.aulast=Klemfuss&rft.aufirst=H&rft.date=1989-07-17&rft.volume=492&rft.issue=1-2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of atenolol and nifedipine in chronic stable angina pectoris. AN - 79063409; 2662743 AB - The antiangina effects of atenolol, 50 to 200 mg once daily, or nifedipine, 10 to 30 mg 3 times daily, were evaluated in a multicenter, randomized, double-blind, parallel study of 39 patients with known symptomatic coronary artery disease. Treatment was titrated to produce at least a 30% increase in treadmill exercise duration over placebo baseline and then maintained at that dosage for an additional 3 weeks. Both treatments produced significant (p less than 0.001) increases in duration of exercise, total work and exercise capacity when compared with placebo baseline. These improvements in exercise performance were obtained with significant (p less than 0.001) reductions in both ST-segment depression and rate-pressure product for atenolol compared with nifedipine. Furthermore, the total angina attack rate and rate at rest were significantly (p less than 0.01) less frequent with atenolol than with nifedipine. Hence, the antiischemic effects of atenolol exceeded those of nifedipine, based on ST-segment depression and rate-pressure product at comparable workloads. JF - The American journal of cardiology AU - Shapiro, W AU - Narahara, K A AU - Kostis, J B AU - Thandroyen, F AU - Zohman, L R AD - Cardiovascular Section, Dallas Veterans Administration Medical Center, Texas 75216. Y1 - 1989/07/15/ PY - 1989 DA - 1989 Jul 15 SP - 186 EP - 190 VL - 64 IS - 3 SN - 0002-9149, 0002-9149 KW - Triglycerides KW - 0 KW - Atenolol KW - 50VV3VW0TI KW - Nifedipine KW - I9ZF7L6G2L KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Triglycerides -- blood KW - Multicenter Studies as Topic KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Aged KW - Exercise Test KW - Electrocardiography KW - Chronic Disease KW - Middle Aged KW - Female KW - Male KW - Angina Pectoris -- drug therapy KW - Nifedipine -- therapeutic use KW - Atenolol -- therapeutic use KW - Atenolol -- adverse effects KW - Angina Pectoris -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79063409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Comparison+of+atenolol+and+nifedipine+in+chronic+stable+angina+pectoris.&rft.au=Shapiro%2C+W%3BNarahara%2C+K+A%3BKostis%2C+J+B%3BThandroyen%2C+F%3BZohman%2C+L+R&rft.aulast=Shapiro&rft.aufirst=W&rft.date=1989-07-15&rft.volume=64&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-10 N1 - Date created - 1989-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sucralfate, intestinal aluminum absorption, and aluminum toxicity in a patient on dialysis. AN - 79061575; 2742249 JF - Annals of internal medicine AU - Robertson, J A AU - Salusky, I B AU - Goodman, W G AU - Norris, K C AU - Coburn, J W AD - Veterans Administration Medical Centers, West Los Angeles, California. Y1 - 1989/07/15/ PY - 1989 DA - 1989 Jul 15 SP - 179 EP - 181 VL - 111 IS - 2 SN - 0003-4819, 0003-4819 KW - Sucralfate KW - 54182-58-0 KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Aluminum KW - CPD4NFA903 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Peritoneal Dialysis KW - Adolescent KW - Aluminum Hydroxide -- metabolism KW - Female KW - Biological Availability KW - Sucralfate -- adverse effects KW - Kidney Failure, Chronic -- metabolism KW - Kidney Failure, Chronic -- therapy KW - Intestinal Absorption KW - Sucralfate -- metabolism KW - Aluminum -- poisoning KW - Aluminum -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79061575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Sucralfate%2C+intestinal+aluminum+absorption%2C+and+aluminum+toxicity+in+a+patient+on+dialysis.&rft.au=Robertson%2C+J+A%3BSalusky%2C+I+B%3BGoodman%2C+W+G%3BNorris%2C+K+C%3BCoburn%2C+J+W&rft.aulast=Robertson&rft.aufirst=J&rft.date=1989-07-15&rft.volume=111&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-04 N1 - Date created - 1989-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. AN - 79054452; 2659990 AB - There is concern that group A streptococci, which have caused less serious infections in developed countries in recent decades, may be acquiring greater virulence. We describe 20 patients from the Rocky Mountain region who had group A streptococcal infections from 1986 to 1988 that were remarkable for the severity of local tissue destruction and life-threatening systemic toxicity. Among the 20 patients (median age, 36), necrotizing fasciitis with or without myositis was the most common soft-tissue infection (55 percent). Nineteen patients (95 percent) had shock, 16 (80 percent) had renal impairment, and 11 (55 percent) had acute respiratory distress syndrome. The mortality rate was 30 percent. All patients but 1 had positive tissue cultures for Streptococcus pyogenes; 12 had positive blood cultures. Most of the patients had no underlying disease; 2 used intravenous drugs. Strains of group A beta-hemolytic streptococci isolated from 10 patients were not of a single M or T type; however, 8 of the 10 strains produced pyrogenic exotoxin A (scarlet fever toxin A, a classic erythrogenic toxin), which has rarely been observed in recent years. From our study of this cluster of severe streptococcal infections with a toxic shock-like syndrome, we conclude that in our region, more virulent group A streptococci have reappeared that produce the pyrogenic toxin A associated with scarlet fever. JF - The New England journal of medicine AU - Stevens, D L AU - Tanner, M H AU - Winship, J AU - Swarts, R AU - Ries, K M AU - Schlievert, P M AU - Kaplan, E AD - Infectious Disease Service, Veterans Administration Medical Center, Boise, Idaho. Y1 - 1989/07/06/ PY - 1989 DA - 1989 Jul 06 SP - 1 EP - 7 VL - 321 IS - 1 SN - 0028-4793, 0028-4793 KW - Bacterial Proteins KW - 0 KW - Exotoxins KW - Membrane Proteins KW - Pyrogens KW - SpeA protein, Streptococcus pyogenes KW - erythrogenic toxin KW - Abridged Index Medicus KW - Index Medicus KW - Virulence KW - Idaho KW - Necrosis KW - Fasciitis -- etiology KW - Humans KW - Adult KW - Serotyping KW - Middle Aged KW - Utah KW - Nevada KW - Myositis -- etiology KW - Male KW - Female KW - Exotoxins -- biosynthesis KW - Pyrogens -- biosynthesis KW - Streptococcus pyogenes -- pathogenicity KW - Streptococcal Infections -- epidemiology KW - Streptococcus pyogenes -- metabolism KW - Streptococcal Infections -- mortality KW - Shock, Septic -- epidemiology KW - Streptococcus pyogenes -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79054452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Severe+group+A+streptococcal+infections+associated+with+a+toxic+shock-like+syndrome+and+scarlet+fever+toxin+A.&rft.au=Stevens%2C+D+L%3BTanner%2C+M+H%3BWinship%2C+J%3BSwarts%2C+R%3BRies%2C+K+M%3BSchlievert%2C+P+M%3BKaplan%2C+E&rft.aulast=Stevens&rft.aufirst=D&rft.date=1989-07-06&rft.volume=321&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-21 N1 - Date created - 1989-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1989 Nov 30;321(22):1545-7 [2682245] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic studies on citrate synthase mutants of yeast. A change in phenotype following transformation with an inactive enzyme. AN - 79062529; 2661555 AB - We have studied the growth on acetate, the metabolism of acetate enzymes, and respiration of a series of citrate synthase mutants of Saccharomyces cerevisiae. The results confirmed and extended our previous observation that cytosolic citrate synthase is not necessary for growth on acetate. Deletion of mitochondrial citrate synthase (CS1) protein resulted in changes in metabolites, decrease in the amounts of pyruvate and alpha-ketoglutarate dehydrogenase complexes, reduced mitochondrial respiration of citrate and isocitrate, and an inability to grow on acetate. Using site-directed mutagensis, we constructed two separate CS1 proteins with mutations in the enzyme's active site. The mitochondria of cells carrying either site-directed mutagenized CS1 contained the inactive citrate synthase protein. With one mutant in which His313 was replaced with a glycine (CS1/H313G), growth on acetate was restored, and mitochondrial respiration of citrate and isocitrate increased toward parental levels as did the levels of several enzymes. With the other mutant CS1 in which Asp414 was replaced with a glycine (CS1/D414G), no growth on acetate or changes in other parameters was observed. We propose that the characteristics of the strain carrying the CS1 with a H313G mutation result from the formation of an intact Krebs cycle complex by the inactive but structurally unchanged H313G protein. JF - The Journal of biological chemistry AU - Kispal, G AU - Evans, C T AU - Malloy, C AU - Srere, P A AD - Pre-Clinical Science Unit, Veterans Administration Medical Center, Dallas, Texas 75216. Y1 - 1989/07/05/ PY - 1989 DA - 1989 Jul 05 SP - 11204 EP - 11210 VL - 264 IS - 19 SN - 0021-9258, 0021-9258 KW - Acetates KW - 0 KW - Pyruvate Dehydrogenase Complex KW - Ketoglutarate Dehydrogenase Complex KW - EC 1.2.4.2 KW - Citrate (si)-Synthase KW - EC 2.3.3.1 KW - Oxo-Acid-Lyases KW - EC 4.1.3.- KW - Index Medicus KW - Oxidation-Reduction KW - Oxygen Consumption KW - Transformation, Genetic KW - Mitochondria -- enzymology KW - Ketoglutarate Dehydrogenase Complex -- metabolism KW - Acetates -- metabolism KW - Mutation KW - Pyruvate Dehydrogenase Complex -- metabolism KW - Cloning, Molecular KW - Citric Acid Cycle KW - Binding Sites KW - Saccharomyces cerevisiae -- genetics KW - Phenotype KW - Oxo-Acid-Lyases -- genetics KW - Saccharomyces cerevisiae -- growth & development KW - Citrate (si)-Synthase -- metabolism KW - Saccharomyces cerevisiae -- enzymology KW - Citrate (si)-Synthase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79062529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Metabolic+studies+on+citrate+synthase+mutants+of+yeast.+A+change+in+phenotype+following+transformation+with+an+inactive+enzyme.&rft.au=Kispal%2C+G%3BEvans%2C+C+T%3BMalloy%2C+C%3BSrere%2C+P+A&rft.aulast=Kispal&rft.aufirst=G&rft.date=1989-07-05&rft.volume=264&rft.issue=19&rft.spage=11204&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-02 N1 - Date created - 1989-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recovery and Evolution of a Subtype of Crossed Aphasia AN - 85329075; llba-8908761 AB - Described is the case of a 61-year-old right-handed male who developed global language deficits & muteness following a right hemisphere middle cerebral artery distribution infarct involving the frontal, inferior parietal, & superior temporal lobes. Language was evaluated serially during the early stages of recovery in order to document the evolution of this syndrome with regard to the observed areas of linguistic change. Auditory comprehension & information content were the areas showing the greatest change during the early stages of recovery, whereas gains in fluency were limited. By 48 days postonset, this patient's linguistic profile was behaviorally compatible with the Broca's aphasia seen with left-hemisphere lesions. 1 Table, 3 Figures, 38 References. HA JF - Aphasiology AU - Ochipa, Cynthia AU - Gonzalez Rothi, Leslie J AD - c/o Rothi-Speech Pathology Veterans Administration Medical Center, Gainesville FL 32602 Y1 - 1989/07// PY - 1989 DA - Jul 1989 SP - 465 EP - 472 VL - 3 IS - 5 SN - 0268-7038, 0268-7038 KW - crossed aphasia subtype, recovery/evolution, observed linguistic change KW - right-handed male aged 61 KW - *Language Therapy (la7a) KW - *Language Pathology (la4) KW - *Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85329075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Recovery+and+Evolution+of+a+Subtype+of+Crossed+Aphasia&rft.au=Ochipa%2C+Cynthia%3BGonzalez+Rothi%2C+Leslie+J&rft.aulast=Ochipa&rft.aufirst=Cynthia&rft.date=1989-07-01&rft.volume=3&rft.issue=5&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Language Pathology (la4); *Aphasia (ap1); *Language Therapy (la7a) ER - TY - JOUR T1 - Treatment outcomes of Vietnam veterans with PTSD and the consistency of the MCMI. AN - 85246009; pmid-2768493 AB - This study addresses two issues: treatment changes on the MCMI of Vietnam veterans with PTSD and test-retest reliability of the Millon Clinical Multiaxial Inventory (MCMI). Fifty Vietnam veterans carefully were identified for the diagnosis Post-Traumatic Stress Disorder (PTSD). They were admitted to a Special PTSD Treatment Unit that consisted of an intense 5-week period with focus on the revivified Vietnam experience. They also were given the MCMI at two points in time, treatment inception and 35 days later at discharge. Results show that 17 of 20 scales on the MCMI changed in the negative direction as a result of treatment. Also, the MCMI has adequate test-retest reliability, and the personality scales (with the exception of Borderline) have higher reliability coefficients than do symptom scales. The use of the MCMI is encourged both as a monitor of treatment for these veterans and for its stability. JF - Journal of Clinical Psychology AU - Hyer, L AU - Woods, M G AU - Bruno, R AU - Boudewyns, P AD - Veterans Administration Medical Center, Augusta, Georgia. PY - 1989 SP - 547 EP - 552 VL - 45 IS - 4 SN - 0021-9762, 0021-9762 KW - Veterans KW - Psychotherapy, Group KW - Combat Disorders KW - Human KW - Stress Disorders, Post-Traumatic KW - Follow-Up Studies KW - Psychiatric Department, Hospital KW - Male KW - Problem Solving KW - Vietnam KW - Personality Inventory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85246009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Treatment+outcomes+of+Vietnam+veterans+with+PTSD+and+the+consistency+of+the+MCMI.&rft.au=Hyer%2C+L%3BWoods%2C+M+G%3BBruno%2C+R%3BBoudewyns%2C+P&rft.aulast=Hyer&rft.aufirst=L&rft.date=1989-07-01&rft.volume=45&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Facilitating training in tracheoesophageal prosthesis placement. AN - 85227602; pmid-2736097 AB - Success in the utilization of a tracheoesophageal voice prosthesis may be limited due to the failure to learn how to insert the prosthesis independently. Reasons that may account for this inadequacy include inadequate preoperative screening tools to assess adequacy of the insertion process and lack of the availability of a model that allows safe practice in the skills necessary for insertion and retention. To avoid these possible complications, a model has been developed that will assist the medical care team in preoperative evaluation and postoperative care. JF - Archives of Otolaryngology--Head and Neck Surgery AU - Enderle, E E AU - Groher, M E AD - Department of Audiology/Speech Pathology, Veterans Administration Medical Center, New York, NY. PY - 1989 SP - 853 EP - 855 VL - 115 IS - 7 SN - 0886-4470, 0886-4470 KW - Self Care KW - Humans KW - Punctures KW - Tracheostomy KW - Larynx, Artificial KW - Patient Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85227602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Facilitating+training+in+tracheoesophageal+prosthesis+placement.&rft.au=Enderle%2C+E+E%3BGroher%2C+M+E&rft.aulast=Enderle&rft.aufirst=E&rft.date=1989-07-01&rft.volume=115&rft.issue=7&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.issn=08864470&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Toxic megacolon in cytomegalovirus colitis. AN - 85226271; pmid-2545094 AB - We report a case of toxic megacolon manifesting in cytomegalovirus (CMV) colitis in a 55-yr-old man with steroid-dependent chronic obstructive pulmonary disease. He presented to the hospital with increasing dyspnea and low-grade fever. His hospital course was characterized by the poor response of his symptoms to treatment, and by the subsequent development of intermittent hematochezia and, eventually, acute abdomen. The surgical specimen showed dilatation of the cecum and ascending colon with a solitary mucosal ulcer in the latter. The major histologic changes were limited to the area of ulceration. In addition to classical CMV inclusions. vasculitis manifested in two forms, namely, leukocytoclastic type and fibrinoid necrosis. The patient died shortly thereafter, due to multi-organ system failure. To our knowledge, this represents the first reported case of toxic megacolon due to CMV infection without underlying inflammatory bowel disease. The pathogenesis of toxic colonic dilatation remains unknown. JF - The American Journal of Gastroenterology AU - Orloff, J J AU - Saito, R AU - Lasky, S AU - Dave, H AD - Medical Services, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. PY - 1989 SP - 794 EP - 797 VL - 84 IS - 7 SN - 0002-9270, 0002-9270 KW - Human KW - Cytomegalovirus Infections KW - Inclusion Bodies, Viral KW - Middle Age KW - Case Report KW - Colitis, Ulcerative KW - Megacolon, Toxic KW - Colitis KW - Cytomegalovirus KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Toxic+megacolon+in+cytomegalovirus+colitis.&rft.au=Orloff%2C+J+J%3BSaito%2C+R%3BLasky%2C+S%3BDave%2C+H&rft.aulast=Orloff&rft.aufirst=J&rft.date=1989-07-01&rft.volume=84&rft.issue=7&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - In vitro comparison of cefpirome and four other beta-lactam antibiotics alone and in combination with tobramycin against clinical isolates of Pseudomonas aeruginosa. AN - 79357436; 2512048 AB - In vitro susceptibility studies of cefpirome versus cefotaxime, ceftazidime, imipenem, and piperacillin alone and in combination with tobramycin were performed against 153 clinical isolates of Pseudomonas aeruginosa from four medical centers. The minimal inhibitory concentration (MIC) for each antibiotic alone was determined by a standardized dilution method. Antibiotic combination studies were performed using a modified checkerboard technique. Cefpirome alone was more active (MIC90 64 micrograms/ml) than piperacillin (MIC90 128 micrograms/ml) or cefotaxime (MIC90 256 micrograms/ml) but less active than imipenem (MIC90 2 micrograms/ml) or ceftazidime (MIC90 32 micrograms/ml). The addition of tobramycin reduced the MICs of all of the beta-lactam antibiotics except for imipenem. The MIC90 for cefpirome when combined with tobramycin was 8 micrograms/ml compared to 16 micrograms/ml for cefotaxime and piperacillin, 8 micrograms/ml for ceftazidime, and 4 micrograms/ml for imipenem. The combination of tobramycin and cefpirome proved to be additive or synergistic for 82% of the isolates (highest rate) compared to 31% with imipenem (lowest rate). The potent in vitro antipseudomonal activity of cefpirome alone and in combination with an aminoglycoside (tobramycin) suggests that this agent may play a useful role in the therapy of infections due to P. aeruginosa. JF - Diagnostic microbiology and infectious disease AU - Cabezudo, I AU - Pfaller, M AU - Bale, M AU - Wenzel, R AD - Veterans Administration Medical Center, Iowa City, Iowa. PY - 1989 SP - 337 EP - 341 VL - 12 IS - 4 SN - 0732-8893, 0732-8893 KW - Anti-Bacterial Agents KW - 0 KW - Cephalosporins KW - cefpirome KW - S72Q2F09HY KW - Tobramycin KW - VZ8RRZ51VK KW - Index Medicus KW - Pseudomonas Infections -- drug therapy KW - Humans KW - In Vitro Techniques KW - Drug Therapy, Combination -- pharmacology KW - Drug Resistance, Microbial KW - Anti-Bacterial Agents -- pharmacology KW - Cross Infection -- drug therapy KW - Anti-Bacterial Agents -- administration & dosage KW - Drug Synergism KW - Pseudomonas aeruginosa -- isolation & purification KW - Cephalosporins -- pharmacology KW - Tobramycin -- pharmacology KW - Cephalosporins -- administration & dosage KW - Pseudomonas aeruginosa -- drug effects KW - Tobramycin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79357436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+microbiology+and+infectious+disease&rft.atitle=In+vitro+comparison+of+cefpirome+and+four+other+beta-lactam+antibiotics+alone+and+in+combination+with+tobramycin+against+clinical+isolates+of+Pseudomonas+aeruginosa.&rft.au=Cabezudo%2C+I%3BPfaller%2C+M%3BBale%2C+M%3BWenzel%2C+R&rft.aulast=Cabezudo&rft.aufirst=I&rft.date=1989-07-01&rft.volume=12&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-17 N1 - Date created - 1990-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anxiety and pain response changes across treatment: sensory decision analysis. AN - 79212355; 2780061 AB - Relationships between anxiety and pain perception were investigated by comparing pre- and post-pain reactions of highly anxious detoxified substance abusers categorized on the basis of anxiety level changes over treatment. Sensory decision theory methodology was applied to measure discriminative and decisional aspects of pain response. Men exhibiting significant pre-post-anxiety state decreases showed greater discriminability index increases and greater response bias index decreases at post-test, compared to their counterparts exhibiting minimal changes in severe anxiety levels across treatment. Findings have relevance for understanding pain perception and interventions in clinical samples. JF - Pain AU - Malow, R M AU - West, J A AU - Sutker, P B AD - Veterans Administration Medical Center, Department of Psychiatry and Neurology, New Orleans, L 70146. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 35 EP - 44 VL - 38 IS - 1 SN - 0304-3959, 0304-3959 KW - Index Medicus KW - Substance Withdrawal Syndrome -- physiopathology KW - Humans KW - Adult KW - Anxiety -- physiopathology KW - Male KW - Pain -- psychology KW - Sensory Thresholds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79212355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Anxiety+and+pain+response+changes+across+treatment%3A+sensory+decision+analysis.&rft.au=Malow%2C+R+M%3BWest%2C+J+A%3BSutker%2C+P+B&rft.aulast=Malow&rft.aufirst=R&rft.date=1989-07-01&rft.volume=38&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=03043959&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-19 N1 - Date created - 1989-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of rapid urease tests, staining techniques, and growth on different solid media for detection of Campylobacter pylori. AN - 79182857; 2475524 AB - Thirty-nine single antral biopsies (phase 1) and 99 sets of six antral biopsies (phase 2) were collected from 132 patients, and 87 (63%) yielded positive cultures for Campylobacter pylori. Of several primary media tested in phase 1, tryptic soy agar and Skirrow agar, each supplemented with 10% whole sheep blood, supported relatively good growth of C. pylori. In phase 2, four of the six biopsies in each set were tested with different urease systems. Selective urea agar for rapid identification was the most sensitive (39 of 63 [62%] at 1 h) and specific (100%); however, the difference between this system and the CLOtest was not statistically significant. The remaining two biopsies, one transported in saline and the other transported in a supplemented tryptic soy broth, were ground separately and inoculated onto tryptic soy agar and Skirrow agar, each supplemented with 10% whole sheep blood. In selected instances, 10% horse serum or 10% horse serum and 5 mM urea or 1% cholesterol were also added to the media. Smears stained with a modified Gram stain or acridine orange detected 68% of 63 culture-positive biopsies; no false-positive results were reported. Skirrow agar supported better growth of C. pylori than did tryptic soy agar; the nonselective medium was also overgrown with contaminants in 25 to 30% of the positive cultures. Based on colony size, Skirrow agar supplemented with 10% whole sheep blood, 10% horse serum, and 1% cholesterol supported optimal growth of C. pylori. Fresh media supported better growth than did prepoured commercial media (P less than or equal to 0.004). Saline was a convenient and satisfactory transport medium for antral biopsies. JF - Journal of clinical microbiology AU - Coudron, P E AU - Kirby, D F AD - Laboratory Service, McGuire Veterans Administration Medical Center, Richmond, Virginia 23249. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 1527 EP - 1530 VL - 27 IS - 7 SN - 0095-1137, 0095-1137 KW - Culture Media KW - 0 KW - Gram's stain KW - Phenazines KW - Urease KW - EC 3.5.1.5 KW - Acridine Orange KW - F30N4O6XVV KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Gastroscopy KW - Urease -- analysis KW - Humans KW - Predictive Value of Tests KW - Biopsy KW - Pyloric Antrum KW - Staining and Labeling KW - Campylobacter -- growth & development KW - Campylobacter Infections -- microbiology KW - Campylobacter -- enzymology KW - Stomach -- microbiology KW - Gastritis -- microbiology KW - Campylobacter -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79182857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+rapid+urease+tests%2C+staining+techniques%2C+and+growth+on+different+solid+media+for+detection+of+Campylobacter+pylori.&rft.au=Coudron%2C+P+E%3BKirby%2C+D+F&rft.aulast=Coudron&rft.aufirst=P&rft.date=1989-07-01&rft.volume=27&rft.issue=7&rft.spage=1527&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-27 N1 - Date created - 1989-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med J Aust. 1985 Apr 15;142(8):436-9 [3982345] J Clin Pathol. 1985 Oct;38(10):1127-31 [3902897] J Infect Dis. 1986 Apr;153(4):664-9 [3950448] Am J Gastroenterol. 1987 Mar;82(3):200-10 [3548326] J Clin Microbiol. 1988 Jul;26(7):1393-4 [3410949] J Clin Microbiol. 1987 Jun;25(6):1117-8 [3597756] J Clin Microbiol. 1987 Aug;25(8):1359-63 [3624435] Gastroenterology. 1988 Jan;94(1):33-40 [3335295] J Clin Microbiol. 1988 May;26(5):948-9 [3384915] J Clin Microbiol. 1987 Apr;25(4):597-9 [3571466] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical meaning of the Keane PTSD Scale. AN - 79175035; 2768492 AB - A correlational study that included 82 male inpatient alcoholics was conducted to determine the clinical meaning of the Keane PTSD Scale of the MMPI. The PTSD Scale was correlated with the variables of the Shipley Institute of Living Scale, the Life Purpose Questionnaire, the Existential Depression Test, and the standard MMPI measures, plus the A, R, Es and MacAndrew Scales. The pattern of correlations suggested that the PTSD scale measures general psychological maladjustment and dysphoric feelings rather than any specifiable syndrome. The strong correlation with the Welch A, which measures a general level of maladjustment, suggests that the PTSD and Welch A scales are measuring the same factor. The PTSD scale, therefore, appears to provide very little information about this population beyond that available from the overall clinical profile and the Welch A scale. JF - Journal of clinical psychology AU - Moody, D R AU - Kish, G B AD - Veterans Administration Medical Center, Salem, VA 24153. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 542 EP - 546 VL - 45 IS - 4 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Intelligence KW - Combat Disorders -- psychology KW - Motivation KW - Depressive Disorder -- psychology KW - Humans KW - Adult KW - Middle Aged KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Stress Disorders, Post-Traumatic -- psychology KW - MMPI KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79175035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Clinical+meaning+of+the+Keane+PTSD+Scale.&rft.au=Moody%2C+D+R%3BKish%2C+G+B&rft.aulast=Moody&rft.aufirst=D&rft.date=1989-07-01&rft.volume=45&rft.issue=4&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-05 N1 - Date created - 1989-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sclerotherapy-associated esophageal ulcers: lessons from a double-blind, randomized comparison of sucralfate suspension versus placebo. AN - 79165585; 2670659 AB - We undertook a double-blind randomized trial to assess whether sucralfate suspension would accelerate healing of sclerotherapy-associated esophageal ulcers. Consecutive patients who underwent sclerotherapy were evaluated. Patients were prospectively endoscoped 4 days (range, 3 to 5 days) after sclerotherapy. Those with ulcers greater than 5 mm in diameter were randomized to receive sucralfate suspension, 4 g/day (10 ml four times a day), or placebo. Endoscopic evaluations were done weekly for the 4 weeks of therapy. Nineteen patients survived long enough to be evaluated; complete ulcer healing was scored as success. Nine patients (13 ulcers) received sucralfate and 10 patients (17 ulcers) received placebo. At the end of 4 weeks, 78% of ulcers in sucralfate-treated patients had healed compared with 40% in the placebo group (p = not significant). Large ulcers were found to heal more slowly (p = 0.03, life table analysis) and small ulcers were disproportionally represented in patients receiving sucralfate (67% compared with 40% in the placebo group). When ulcer size was taken into account, the possible drug advantage disappeared; ulcer size appears to be a major determinant of rate of healing of sclerotherapy-associated esophageal ulcers. A large multicenter trial will be required to identify whether sucralfate accelerates postsclerotherapy esophageal ulcer healing. JF - Gastrointestinal endoscopy AU - Tabibian, N AU - Smith, J L AU - Graham, D Y AD - Digestive Disease Section, Veterans Administration Medical Center, Houston, Texas 77030. PY - 1989 SP - 312 EP - 315 VL - 35 IS - 4 SN - 0016-5107, 0016-5107 KW - Sclerosing Solutions KW - 0 KW - Suspensions KW - Sucralfate KW - 54182-58-0 KW - Index Medicus KW - Esophageal and Gastric Varices -- therapy KW - Double-Blind Method KW - Random Allocation KW - Wound Healing -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Gastrointestinal Hemorrhage -- therapy KW - Ulcer -- drug therapy KW - Ulcer -- chemically induced KW - Sucralfate -- therapeutic use KW - Sclerosing Solutions -- adverse effects KW - Esophageal Diseases -- physiopathology KW - Esophageal Diseases -- drug therapy KW - Ulcer -- physiopathology KW - Sclerosing Solutions -- therapeutic use KW - Esophageal Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79165585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy&rft.atitle=Sclerotherapy-associated+esophageal+ulcers%3A+lessons+from+a+double-blind%2C+randomized+comparison+of+sucralfate+suspension+versus+placebo.&rft.au=Tabibian%2C+N%3BSmith%2C+J+L%3BGraham%2C+D+Y&rft.aulast=Tabibian&rft.aufirst=N&rft.date=1989-07-01&rft.volume=35&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy&rft.issn=00165107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-29 N1 - Date created - 1989-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Monoclonal antibodies specific for antigens expressed by rat type II alveolar epithelial and nonciliated bronchiolar cells. AN - 79164354; 2767007 AB - Markers specific for various lung cells are useful for studies of cellular differentiation and function. We have produced monoclonal antibodies that bind to isolated rat type II alveolar epithelial cells in an ELISA. Two such antibodies, 2C1 and 3F9, specifically labeled type II cells and nonciliated bronchiolar cells by indirect immunofluorescence of rat lung. A third antibody, 2A3, recognized isolated type II cells by ELISA and immunofluorescence, but did not bind to sections of whole lung. Further immunofluorescence studies on adult rat tissue showed that neither 2C1 nor 3F9 labeled other lung cells or cells in kidney, small intestine, brain, or trachea. The antigen or antigens recognized by 2C1 and 3F9 was not detectable at day 15 of fetal lung gestation but was detectable by day 21. Immunofluorescence studies carried out on 0.5-microns frozen sections of lung tissue demonstrated that both 2C1 and 3F9 bound to cell surface antigens, which are expressed in a highly polarized fashion on the luminal surface of the alveolus and bronchiole. The rat cell line, L2, which displays some similarities to type II cells, did not display positive immunofluorescence to 2A3, 2C1, or 3F9. The antibodies 2C1 and 3F9 are distinct from and apparently more specific than previously described monoclonal antibodies raised to rat type II cells. Alveolar type II and nonciliated bronchiolar cells share several common features. Both cell types contain the surfactant apoprotein SP-A, proliferate in response to lung injury, develop in the late stages of gestation, take up and catabolize platelet-activating factor, contain high levels of cytochrome P-450, and can be induced to form tumors in response to chemical carcinogens. The recognition of highly specific surface antigen(s) on both nonciliated bronchiolar cells and type II cells demonstrates yet another characteristic shared by the two cell types. JF - Experimental lung research AU - Miller, Y E AU - Walker, S R AU - Spencer, J S AU - Kubo, R T AU - Mason, R J AD - Department of Medicine, Denver Veterans Administration Medical Center, CO 80220. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 635 EP - 649 VL - 15 IS - 4 SN - 0190-2148, 0190-2148 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, Surface KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Immunohistochemistry KW - Male KW - Bronchi -- cytology KW - Pulmonary Alveoli -- immunology KW - Pulmonary Alveoli -- cytology KW - Bronchi -- immunology KW - Antigens, Surface -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79164354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Monoclonal+antibodies+specific+for+antigens+expressed+by+rat+type+II+alveolar+epithelial+and+nonciliated+bronchiolar+cells.&rft.au=Miller%2C+Y+E%3BWalker%2C+S+R%3BSpencer%2C+J+S%3BKubo%2C+R+T%3BMason%2C+R+J&rft.aulast=Miller&rft.aufirst=Y&rft.date=1989-07-01&rft.volume=15&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-03 N1 - Date created - 1989-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Communication skills training with alcoholics for improving performance of two of the alcoholics anonymous recovery steps. AN - 79134524; 2755136 AB - Thousands of men and women have begun their recovery from alcoholism through the support of Alcoholics Anonymous (AA). AA recognizes its social support role in defining itself as a "fellowship," but it also sees itself as offering a program of recovery. This program is comprised of the well-known "12-Step" method, which has been adapted by a variety of self-help groups. The purpose of the present study was to determine whether performance of two of these steps, Steps 4 and 5, could be facilitated by teaching communication skills specifically designed to improve their performance. Hospitalized alcoholics were assigned to communication-skills training, discussion and assessment-only groups, and their pre- and posttreatment performance on videotaped role-plays of Steps 4 and 5 was assessed. Subjects in the communication-skills training group were found to improve significantly on internal versus external focus, personal responsibility taking, congruent affect and composite skill variables compared to the discussion and assessment-only groups. These results suggest that, among treatment programs that utilize AA's recovery program, the behavioral skills inherent in completing Steps 4 and 5 need to be taught. Merely discussing or alluding to the steps, as is often-times done in group therapy of "step-study" sessions, is unlikely to have any effect on alcoholics' abilities to "work the steps." JF - Journal of studies on alcohol AU - Anderson, J G AU - Gilbert, F S AD - Alcoholism Rehabilitation Laboratory, Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 361 EP - 367 VL - 50 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Self Disclosure KW - Humans KW - Adult KW - Role Playing KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Communication KW - Alcoholics Anonymous KW - Behavior Therapy -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79134524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Communication+skills+training+with+alcoholics+for+improving+performance+of+two+of+the+alcoholics+anonymous+recovery+steps.&rft.au=Anderson%2C+J+G%3BGilbert%2C+F+S&rft.aulast=Anderson&rft.aufirst=J&rft.date=1989-07-01&rft.volume=50&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Change in drinking behaviors with retirement: findings from the normative aging study. AN - 79134498; 2787876 AB - This study examines changes in drinking behaviors over an approximately 2-year span in two groups of community-dwelling men: 100 men who retired between baseline (T1) and follow-up (T2) and 316 men who remained employed. Measures were obtained from two drinking surveys conducted as part of a panel study of aging. Results indicate that the event of retirement was not a significant predictor of changes in average alcohol consumption, although retirees showed more variability between T1 and T2. Considering other binary drinking behavior variables, continuing workers and eventual retirees did not differ in the proportions moving into or out of the nondrinker status, or the situation of consuming an average of 3+ drinks/day. However, retirees by T2 were more likely to report the onset of periodic heavier drinking and problems with drinking. Evidence from this study indicates that retirement generally heralds no great shift in alcohol consumption or drinking behaviors. JF - Journal of studies on alcohol AU - Ekerdt, D J AU - De Labry, L O AU - Glynn, R J AU - Davis, R W AD - Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 347 EP - 353 VL - 50 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Cross-Sectional Studies KW - Reference Values KW - Prospective Studies KW - Massachusetts KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Alcoholism -- epidemiology KW - Alcohol Drinking -- psychology KW - Alcoholism -- psychology KW - Retirement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79134498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Change+in+drinking+behaviors+with+retirement%3A+findings+from+the+normative+aging+study.&rft.au=Ekerdt%2C+D+J%3BDe+Labry%2C+L+O%3BGlynn%2C+R+J%3BDavis%2C+R+W&rft.aulast=Ekerdt&rft.aufirst=D&rft.date=1989-07-01&rft.volume=50&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical pharmacology of centrally acting antihypertensive agents. AN - 79133645; 2668350 AB - The centrally acting agents are one of several differing classes of drugs now available for antihypertensive therapy. The availability of newer pharmacologic classes, including the beta-blockers, alpha-blockers. ACE inhibitors and calcium channel blockers, has resulted in a relative decline in the use of the centrally acting drugs. A major reason for this change in emphasis has been the perception by clinicians that the centrally acting agents, although effective, tend to produce symptomatic side effects that are difficult or unacceptable for patients. Some recent innovations in administering the centrally acting drugs appear to have addressed this problem. The pharmacokinetic characteristics of agents such as the transdermally administered clonidine or oral guanfacine appear to provide them with sustained efficacy without concomitant adverse effects. A further attribute of these drugs is their ability to decrease blood pressure without producing sodium retention. A growing awareness of the importance of treatment-induced metabolic effects has further served to reawaken interest in these agents. Specifically, they do not appear to produce alterations in glucose metabolism, and possibly may even have some slight beneficial effects on the blood lipid profile. Their ability to cause regression of left ventricular muscle hypertrophy, and possibly to enhance diastolic function, may add a further dimension of cardiovascular protection beyond their antihypertensive efficacy. JF - Journal of clinical pharmacology AU - Weber, M A AD - Hypertension Center, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 598 EP - 602 VL - 29 IS - 7 SN - 0091-2700, 0091-2700 KW - Antihypertensive Agents KW - 0 KW - Guanidines KW - Phenylacetates KW - Guanfacine KW - 30OMY4G3MK KW - Methyldopa KW - 56LH93261Y KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Phenylacetates -- pharmacokinetics KW - Methyldopa -- administration & dosage KW - Clonidine -- administration & dosage KW - Dose-Response Relationship, Drug KW - Guanidines -- administration & dosage KW - Humans KW - Clonidine -- adverse effects KW - Clonidine -- therapeutic use KW - Phenylacetates -- administration & dosage KW - Guanidines -- therapeutic use KW - Methyldopa -- therapeutic use KW - Risk Factors KW - Phenylacetates -- adverse effects KW - Guanidines -- pharmacokinetics KW - Clonidine -- pharmacokinetics KW - Guanidines -- adverse effects KW - Blood Pressure -- drug effects KW - Phenylacetates -- therapeutic use KW - Hypertension -- physiopathology KW - Antihypertensive Agents -- pharmacokinetics KW - Antihypertensive Agents -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79133645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Clinical+pharmacology+of+centrally+acting+antihypertensive+agents.&rft.au=Weber%2C+M+A&rft.aulast=Weber&rft.aufirst=M&rft.date=1989-07-01&rft.volume=29&rft.issue=7&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Impaired priming of new associations in amnesia. AN - 79128713; 2526859 AB - We assessed priming of new associations in amnesic patients and healthy control subjects in a paradigm developed by Graf and Schacter (1985). Subjects were presented unrelated word pairs embedded in sentences (e.g., A BELL was hanging over the baby's CRADLE) and were asked to rate how well the sentences related the two words. Subjects were then given a word completion test. They were shown three-letter word stems and were asked to complete the stem with the first word that came to mind. In the same context condition, each word stem was presented together with the word that had appeared in the same sentence during study (e.g., BELL-CRA--). In the different context condition, each stem was presented together with a new word that had never been presented (e.g., APPLE-CRA--). Control subjects completed more words in the same context condition than in the different context condition. In contrast, amnesic patients did not complete any more words in the same context condition than in the different context condition. Indeed, across two experiments none of the amnesic patients exhibited consistent priming of new associations. Thus, although amnesic patients do exhibit entirely normal priming of preexisting memory representations, they do not appear to exhibit priming of new associations in this paradigm. JF - Journal of experimental psychology. Learning, memory, and cognition AU - Shimamura, A P AU - Squire, L R AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 721 EP - 728 VL - 15 IS - 4 SN - 0278-7393, 0278-7393 KW - Index Medicus KW - Humans KW - Cues KW - Middle Aged KW - Mental Recall KW - Neuropsychological Tests KW - Attention KW - Male KW - Female KW - Alcohol Amnestic Disorder -- psychology KW - Amnesia -- psychology KW - Paired-Associate Learning KW - Brain Damage, Chronic -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79128713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+psychology.+Learning%2C+memory%2C+and+cognition&rft.atitle=Impaired+priming+of+new+associations+in+amnesia.&rft.au=Shimamura%2C+A+P%3BSquire%2C+L+R&rft.aulast=Shimamura&rft.aufirst=A&rft.date=1989-07-01&rft.volume=15&rft.issue=4&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+psychology.+Learning%2C+memory%2C+and+cognition&rft.issn=02787393&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-30 N1 - Date created - 1989-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Self-efficacy and relapse among inpatient drug and alcohol abusers: a predictor of outcome. AN - 79116091; 2787877 AB - Monthly intreatment ratings of self-efficacy to avoid drug and alcohol abuse were examined among 419 substance abuse inpatients of a residential treatment community. Posttreatment interviews were conducted with 81 patients approximately 6 months following discharge to assess the relationship between self-efficacy and relapse. As expected, self-efficacy increased during treatment and was higher among abstainers than relapsers at follow-up. Contrary to expectations, low self-efficacy at intake was related to longer inpatient residence and more positive conditions of discharge. Furthermore, abstainers had slightly lower self-efficacy scores than relapsers at intake and increased their self-efficacy two-fold over relapsers during the course of treatment. Contrary to previous research with tobacco smoking, self-efficacy ratings at the end of treatment were not related to substance abuse at follow-up. It is proposed that the present findings are consistent with previous research in demonstrating a relationship between self-efficacy and outcome, and provide new information suggesting that low self-efficacy may be related to positive outcome under certain circumstances. Hypotheses are advanced regarding (1) the potential utility of intreatment change measures, (2) the role of underestimation in self-efficacy ratings and (3) the role of denial in substance abuse populations. JF - Journal of studies on alcohol AU - Burling, T A AU - Reilly, P M AU - Moltzen, J O AU - Ziff, D C AD - Palo Alto Veterans Administration Medical Center, California 94304. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 354 EP - 360 VL - 50 IS - 4 SN - 0096-882X, 0096-882X KW - Amphetamine KW - CK833KGX7E KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - California KW - Therapeutic Community KW - Marijuana Abuse -- rehabilitation KW - Humans KW - Adult KW - Heroin Dependence -- rehabilitation KW - Follow-Up Studies KW - Male KW - Alcoholism -- rehabilitation KW - Self Concept KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79116091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Self-efficacy+and+relapse+among+inpatient+drug+and+alcohol+abusers%3A+a+predictor+of+outcome.&rft.au=Burling%2C+T+A%3BReilly%2C+P+M%3BMoltzen%2C+J+O%3BZiff%2C+D+C&rft.aulast=Burling&rft.aufirst=T&rft.date=1989-07-01&rft.volume=50&rft.issue=4&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drinking-related locus of control and the drinking status of urban Native Americans. AN - 79115337; 2755134 AB - Although promising, the available data concerning drinking-related locus of control have been almost entirely limited to treatment samples of white men. The major purpose of this study was to extend our understanding by comparing the drinking-related expectancies of three groups of Native Americans: problem drinkers, nonproblem drinkers and recovered alcoholics. Multivariate analyses were employed to control statistically for important sociodemographic differences between groups and included a test of the possibility that sex moderated the relationship between drinking status and drinking expectancies. As predicted, problem drinkers reported significantly less personal control of alcohol use than either nonproblem drinkers or recovered alcoholics. There were no significant differences between nonproblem drinkers and recovered alcoholics. Native American men were found to hold significantly more external orientations towards drinking than did women. The results were discussed in terms of comparisons with the available literature, and future research needs were identified. The findings provide indirect support for current treatment philosophies that seek to modify patient perceptions of the controllability of drinking behavior in a more internal direction. JF - Journal of studies on alcohol AU - Mariano, A J AU - Donovan, D M AU - Walker, P S AU - Mariano, M J AU - Walker, R D AD - Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 331 EP - 338 VL - 50 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Washington KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Internal-External Control KW - Alcohol Drinking -- psychology KW - Indians, North American -- psychology KW - Urban Population KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79115337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Drinking-related+locus+of+control+and+the+drinking+status+of+urban+Native+Americans.&rft.au=Mariano%2C+A+J%3BDonovan%2C+D+M%3BWalker%2C+P+S%3BMariano%2C+M+J%3BWalker%2C+R+D&rft.aulast=Mariano&rft.aufirst=A&rft.date=1989-07-01&rft.volume=50&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Altered vascular responses in cyclosporine-treated rats. AN - 79101662; 2749886 AB - Administration of cyclosporine to allograft recipients and patients with immunologically mediated disorders is associated with a high incidence of the development of hypertension. We studied the effect of CsA on blood pressure and on the in vitro tail artery contractile response to transmural nerve stimulation (TNS) and exogenous norepinephrine (NE) in the spontaneously hypertensive rat (SHR). Fourteen days of p.o. administration of CsA 5 mg/kg/day (CsA5) or CsA 20 mg/kg/day (CsA20) resulted in significant increases in blood pressure. The effective level of TNS that resulted in a 50% of maximal response (ED50) was significantly (P less than 0.05) decreased in the CsA5 and CsA20 animals compared to controls. The values for controls (n = 7), CsA5 (n = 10), and CsA20 (n = 9) were 4.3 +/- 0.3, 3.2 +/- 0.3, and 3.1 +/- 0.4 pulses/sec, respectively. In the CsA20 group, the dose-response curve to NE was significantly shifted to the left, and the ED50 was significantly (P less than 0.01) decreased compared to controls (5.7 +/- 0.8 x 10(-5) mol/L, n = 11, vs. 8.9 +/- 0.6 x 10(-5) mol/L, n = 12). We conclude that the in vitro contractile response to nerve stimulation is augmented by CsA. Some of the increase may be related to an enhancement of NE response, but a direct effect on neurovascular function is also suggested. This effect of CsA may be important in the development of hypertension and the changes in neurovascular tone seen with the clinical administration of this immunosuppressant. JF - Transplantation AU - Golub, M S AU - Lustig, S AU - Berger, M E AU - Lee, D B AD - Division of Hypertension, Veterans Administration Medical Center, Los Angeles, California. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 116 EP - 118 VL - 48 IS - 1 SN - 0041-1337, 0041-1337 KW - Cyclosporins KW - 0 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred SHR KW - Hypertension -- physiopathology KW - Norepinephrine -- pharmacology KW - Muscle Contraction -- drug effects KW - Blood Pressure -- drug effects KW - Electric Stimulation KW - Male KW - Cyclosporins -- toxicity KW - Vascular Resistance -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79101662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Altered+vascular+responses+in+cyclosporine-treated+rats.&rft.au=Golub%2C+M+S%3BLustig%2C+S%3BBerger%2C+M+E%3BLee%2C+D+B&rft.aulast=Golub&rft.aufirst=M&rft.date=1989-07-01&rft.volume=48&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-18 N1 - Date created - 1989-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The pharmacodynamic and pharmacokinetic interaction between single doses of flecainide acetate and verapamil: effects on cardiac function and drug clearance. AN - 79082993; 2501057 AB - Flecainide and verapamil are antiarrhythmic agents that may be used in combination. We have examined their pharmacodynamic interaction by M-mode echocardiography and electrocardiography in eight normal male volunteers (24 +/- 1.8 years of age). Flecainide decreased the left ventricular ejection fraction (LVEF) (-4.4 +/- 1.2%, p less than 0.008), but verapamil did not. Neither drug affected cardiac output or vascular resistance. Both drugs increased the PR interval (12 +/- 4 msec, p less than 0.01 for flecainide; 12 +/- 5, p less than 0.04 for verapamil). Flecainide, but not verapamil, increased the QTc interval (23 +/- 8 msec, p less than 0.02). Both drugs also increased the systolic time interval ratio (PEPc/LVETc) (0.074 +/- 0.012, p less than 0.0004 for flecainide; 0.029 +/- 0.008, p less than 0.007 for verapamil). The combination of flecainide and verapamil had additive effects on myocardial contractility and on atrioventricular conduction. Verapamil slightly decreased the plasma clearance of flecainide (7.78 +/- 0.60 ml/kg/min for flecainide alone, 7.34 +/- 0.48 ml/kg/min for flecainide and verapamil together, p less than 0.05). On the other hand, flecainide had no effect on the plasma clearance of verapamil, which suggests that there was little interaction between the two drugs on their pharmacokinetic parameters. JF - Clinical pharmacology and therapeutics AU - Holtzman, J L AU - Finley, D AU - Mottonen, L AU - Berry, D A AU - Ekholm, B P AU - Kvam, D C AU - McQuinn, R L AU - Miller, A M AD - Medical Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 26 EP - 32 VL - 46 IS - 1 SN - 0009-9236, 0009-9236 KW - Verapamil KW - CJ0O37KU29 KW - Flecainide KW - K94FTS1806 KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Drug Interactions KW - Humans KW - Electrocardiography KW - Echocardiography KW - Adult KW - Metabolic Clearance Rate -- drug effects KW - Male KW - Hemodynamics -- drug effects KW - Flecainide -- pharmacology KW - Verapamil -- blood KW - Flecainide -- blood KW - Flecainide -- pharmacokinetics KW - Verapamil -- pharmacokinetics KW - Verapamil -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79082993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=The+pharmacodynamic+and+pharmacokinetic+interaction+between+single+doses+of+flecainide+acetate+and+verapamil%3A+effects+on+cardiac+function+and+drug+clearance.&rft.au=Holtzman%2C+J+L%3BFinley%2C+D%3BMottonen%2C+L%3BBerry%2C+D+A%3BEkholm%2C+B+P%3BKvam%2C+D+C%3BMcQuinn%2C+R+L%3BMiller%2C+A+M&rft.aulast=Holtzman&rft.aufirst=J&rft.date=1989-07-01&rft.volume=46&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-17 N1 - Date created - 1989-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sequential development of polycythemia vera and chronic myelocytic leukemia in a patient following radiation exposure from nuclear weapons tests. AN - 79064114; 2741974 JF - The American journal of medicine AU - Weinberg, J B AD - Veterans Administration, Durham, North Carolina. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 121 EP - 123 VL - 87 IS - 1 SN - 0002-9343, 0002-9343 KW - Radioactive Fallout KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Time Factors KW - Male KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- etiology KW - Nuclear Warfare KW - Polycythemia Vera -- etiology KW - Leukemia, Radiation-Induced KW - Radioactive Fallout -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79064114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Sequential+development+of+polycythemia+vera+and+chronic+myelocytic+leukemia+in+a+patient+following+radiation+exposure+from+nuclear+weapons+tests.&rft.au=Weinberg%2C+J+B&rft.aulast=Weinberg&rft.aufirst=J&rft.date=1989-07-01&rft.volume=87&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Paget's disease of bone in older patients: UCLA grand rounds. AN - 79059464; 2661631 JF - Journal of the American Geriatrics Society AU - Rosenthal, M J AU - Hartnell, J M AU - Kaiser, F E AU - Gharib, D AU - Morley, J E AD - Geriatric Research, Education and Clinical Center, Sepulveda Veterans Administration Medical Center, CA 91343. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 639 EP - 650 VL - 37 IS - 7 SN - 0002-8614, 0002-8614 KW - Diphosphonates KW - 0 KW - Calcitonin KW - 9007-12-9 KW - Index Medicus KW - Osteotomy KW - Orthopedic Equipment KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Aged, 80 and over KW - Humans KW - Calcitonin -- therapeutic use KW - Aged KW - Calcitonin -- adverse effects KW - Male KW - Osteitis Deformans -- therapy KW - Osteitis Deformans -- diagnosis KW - Osteitis Deformans -- physiopathology KW - Osteitis Deformans -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79059464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Paget%27s+disease+of+bone+in+older+patients%3A+UCLA+grand+rounds.&rft.au=Rosenthal%2C+M+J%3BHartnell%2C+J+M%3BKaiser%2C+F+E%3BGharib%2C+D%3BMorley%2C+J+E&rft.aulast=Rosenthal&rft.aufirst=M&rft.date=1989-07-01&rft.volume=37&rft.issue=7&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-01 N1 - Date created - 1989-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. AN - 79055041; 2735812 AB - Dysfunction of the central serotonergic system has been variously associated with depression and with suicidal and/or impulsive aggressive behavior. To evaluate central serotonergic function in relation to these variables, prolactin responses to a single-dose challenge with fenfluramine hydrochloride (60 mg orally), a serotonin releasing/uptake-inhibiting agent, were examined in 45 male patients with clearly defined major affective (n = 25) and/or personality disorder (n = 20) and in 18 normal male control patients. Prolactin responses to fenfluramine among all patients were reduced compared with responses of controls. Reduced prolactin responses to fenfluramine were correlated with history of suicide attempt in all patients but with clinician and self-reported ratings of impulsive aggression in patients with personality disorder only; there was no correlation with depression. These results suggest that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in patients with personality disorder only. JF - Archives of general psychiatry AU - Coccaro, E F AU - Siever, L J AU - Klar, H M AU - Maurer, G AU - Cochrane, K AU - Cooper, T B AU - Mohs, R C AU - Davis, K L AD - Psychiatry Service, Bronx Veterans Administration Medical Center, NY. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 587 EP - 599 VL - 46 IS - 7 SN - 0003-990X, 0003-990X KW - Serotonin Antagonists KW - 0 KW - Fenfluramine KW - 2DS058H2CF KW - Serotonin KW - 333DO1RDJY KW - Prolactin KW - 9002-62-4 KW - Abridged Index Medicus KW - Index Medicus KW - Prolactin -- blood KW - Serotonin Antagonists -- pharmacology KW - Suicide, Attempted -- psychology KW - Humans KW - Fenfluramine -- pharmacology KW - Alcoholism -- psychology KW - Aggression -- physiology KW - Impulsive Behavior -- physiopathology KW - Psychiatric Status Rating Scales KW - Adult KW - Middle Aged KW - Alcoholism -- physiopathology KW - Male KW - Serotonin -- physiology KW - Depressive Disorder -- psychology KW - Depressive Disorder -- physiopathology KW - Personality Disorders -- physiopathology KW - Personality Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79055041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Serotonergic+studies+in+patients+with+affective+and+personality+disorders.+Correlates+with+suicidal+and+impulsive+aggressive+behavior.&rft.au=Coccaro%2C+E+F%3BSiever%2C+L+J%3BKlar%2C+H+M%3BMaurer%2C+G%3BCochrane%2C+K%3BCooper%2C+T+B%3BMohs%2C+R+C%3BDavis%2C+K+L&rft.aulast=Coccaro&rft.aufirst=E&rft.date=1989-07-01&rft.volume=46&rft.issue=7&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Arch Gen Psychiatry 1990 Feb;47(2):124 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Advantages of Abandoning Symptom-Based Diagnostic Systems of Research in Schizophrenia AN - 61583246; 199002444 AB - Symptom-based diagnostic conceptualizations of schizophrenia are inadequate primarily because symptoms may be multidetermined, & are not the same as the disorder itself. An alternative diagnostic system is proposed that redefines schizophrenia in terms other than overt symptoms, emphasizing the processes from which the symptoms spring. Empirical investigation should be used to determine underlying structure; various methodologies are examined. It is proposed that studies should be more clearly directed toward linking symptoms, underlying processes, & etiology. 20 References. Modified HA JF - American Journal of Orthopsychiatry AU - Weiss, Kenneth M AD - Psychology Service 116B(B) Veterans Administration Medical Center, 10000 Brecksville Rd Cleveland OH 44141 Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 324 EP - 330 VL - 59 IS - 3 SN - 0002-9432, 0002-9432 KW - schizophrenia, process-based diagnostic system proposed KW - Schizophrenia KW - Symptoms KW - Diagnosis KW - Medical Research KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61583246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Advantages+of+Abandoning+Symptom-Based+Diagnostic+Systems+of+Research+in+Schizophrenia&rft.au=Weiss%2C+Kenneth+M&rft.aulast=Weiss&rft.aufirst=Kenneth&rft.date=1989-07-01&rft.volume=59&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Diagnosis; Medical Research; Symptoms ER - TY - JOUR T1 - Patterns of Alcohol Abuse among Black and White Alcoholics AN - 61057128; 90V6910 AB - Hospitalized male alcoholics (N = 75 black & 75 white) matched for age & education level were administered the Alcohol Use Inventory (AUI) to differentiate the style of alcohol use between the two groups while minimizing the confounding variables of age, education, & socioeconomic status. The AUI considers alcohol use in terms of physical, psychological, social, & behavior consequences & perceived benefits. A multivariate analysis of variance revealed significant race-related differences in drinking practices as well as in cognitive & emotional consequences. Blacks use alcohol seeking to enhance their mental functioning. They demonstrate a higher incidence of psychoperceptual withdrawal symptoms. Whites consume larger daily quantities of alcohol than blacks, & use alcohol to relieve distress. They demonstrate greater emotional discomfort during withdrawal. These results are inconsistent with earlier characterizations of black alcoholics. It suggested that using larger similarly matched samples that account for rural vs urban settings, religion, gender, personality traits, ethnic association, & attitudes toward treatment would identify subgroups within both black & white populations. Characterization of alcoholic populations should not be separated from variables that identify the meaning & function of alcohol use. 2 Tables, 1 Figure, 26 References. M. Lemons JF - The International Journal of the Addictions AU - Robyak, James E AU - Byers, Patricia H AU - Prange, Mark E AD - Psychiatry Service 116A Veterans Administration Medical Center, Bay Pines FL 33504 Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 715 EP - 724 VL - 24 IS - 7 SN - 0020-773X, 0020-773X KW - alcohol use style, hospitalized male alcoholics, blacks vs whites KW - inventory data KW - Black White Differences KW - Males KW - Alcoholism KW - Drinking Behavior KW - Alcohol Use KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61057128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+the+Addictions&rft.atitle=Patterns+of+Alcohol+Abuse+among+Black+and+White+Alcoholics&rft.au=Robyak%2C+James+E%3BByers%2C+Patricia+H%3BPrange%2C+Mark+E&rft.aulast=Robyak&rft.aufirst=James&rft.date=1989-07-01&rft.volume=24&rft.issue=7&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+the+Addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - INJABN N1 - SubjectsTermNotLitGenreText - Males; Alcoholism; Black White Differences; Alcohol Use; Drinking Behavior ER - TY - JOUR T1 - The forces in a knee brace as a function of hinge design and placement AN - 20070473; 10093314 AB - Customized knee braces for three normal subjects were instrumented to monitor the forces and moments across the hinges as the subjects performed various activities. The forces and moments were taken to rep resent a mismatch between actual knee motion and the motion the brace sought to impose. The different hinge designs studied were fixed axis, gear-on-gear, rack- and-pinion, and natural 3-D; they showed only moder ate differences in forces. Much larger differences were seen if the hinges were offset 12 mm from the ideal placement. Posterior placement resulted in the least force and anterior placement the highest.The mismatch of knee motion to brace motion would probably lead to abnormal ligament lengths and ten sions and other internal mechanical changes, as well as to pistoning and discomfort. The results of this study have implications on brace design, selection, and place ment. JF - American Journal of Sports Medicine AU - Regalbuto, MA AU - Rovick, J S AU - Walker, P S AD - Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, Veterans Administration Medical Center, West Roxbury, Massachusetts Y1 - 1989/07// PY - 1989 DA - Jul 1989 SP - 535 EP - 543 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 17 IS - 4 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Ligaments KW - Knees KW - Braces KW - Activities KW - Sports medicine KW - Movement KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20070473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=The+forces+in+a+knee+brace+as+a+function+of+hinge+design+and+placement&rft.au=Regalbuto%2C+MA%3BRovick%2C+J+S%3BWalker%2C+P+S&rft.aulast=Regalbuto&rft.aufirst=MA&rft.date=1989-07-01&rft.volume=17&rft.issue=4&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658901700415 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Ligaments; Knees; Braces; Sports medicine; Activities; Movement DO - http://dx.doi.org/10.1177/036354658901700415 ER - TY - JOUR T1 - The effect of low dose of 12-O-tetradecanoyl-phorbol-13-acetate on collagen platelet interactions. AN - 79208874; 2551058 AB - We and others have reported that phorbol ester doses ranging from 0.25 to 25 micrograms/ml induce human platelets to aggregate and release serotonin. In this paper, we report the effect of low doses of phorbol (0.5 to 50 ng/ml) on subthreshold amounts of collagen induced platelet aggregation. The platelet aggregation induced by the addition of subthreshold amounts of collagen can be enhanced by low doses of phorbol. The combined low doses of phorbol and subthreshold amounts of collagen induced platelet aggregation can be inhibited by the addition of aspirin and imidazole. The increase in platelet aggregation induced by the combined low doses of phorbol and subthreshold amounts of collagen is probably mediated by the collagen fibril formation. JF - Thrombosis research AU - Chiang, T M AD - Veterans Administration Medical Center, Memphis, TN. Y1 - 1989/06/15/ PY - 1989 DA - 1989 Jun 15 SP - 633 EP - 641 VL - 54 IS - 6 SN - 0049-3848, 0049-3848 KW - Serotonin KW - 333DO1RDJY KW - Collagen KW - 9007-34-5 KW - Cyclic AMP KW - E0399OZS9N KW - Cyclic GMP KW - H2D2X058MU KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Cyclic GMP -- analysis KW - Phosphorylation KW - Dose-Response Relationship, Drug KW - Humans KW - In Vitro Techniques KW - Cyclic AMP -- analysis KW - Microscopy, Electron KW - Serotonin -- metabolism KW - Platelet Aggregation -- drug effects KW - Aspirin -- pharmacology KW - Collagen -- blood KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Tetradecanoylphorbol Acetate -- administration & dosage KW - Blood Platelets -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79208874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thrombosis+research&rft.atitle=The+effect+of+low+dose+of+12-O-tetradecanoyl-phorbol-13-acetate+on+collagen+platelet+interactions.&rft.au=Chiang%2C+T+M&rft.aulast=Chiang&rft.aufirst=T&rft.date=1989-06-15&rft.volume=54&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Thrombosis+research&rft.issn=00493848&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-26 N1 - Date created - 1989-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retention of radiolead by human erythrocytes in vitro. AN - 79053695; 2734794 AB - An in vitro method was developed to assess human erythrocyte lead uptake and release directly, rapidly, and reproducibly; the technique requires small aliquots of blood and uses silicone fluid to separate erythrocytes from their suspending media. Uptake occurred rapidly and was directly related to temperature. Increasing quantities of available elemental lead were associated with increasing absolute quantities but decreasing percentages of uptake. Low values of pH diminished the uptake and enhanced the release of radiolead by erythrocytes, and could be correlated with diminished lead-hemoglobin binding para-Chloromecuribenzoate increased and dithiothreitol inhibited radiolead uptake but neither compound affected lead release, suggesting that sulfhydryl groups are important for lead binding to the erythrocyte. Cyanamide and N-ethylmaleimide did not significantly affect the net uptake or release of radiolead. Calcium disodium EDTA, penicillamine, and dimercaprol significantly reduced lead uptake, although only incubation with dimercaprol resulted in a net removal of lead from erythrocytes. Iron and ceruloplasmin significantly decreased radiolead uptake, but inorganic metal cations other than iron, hyperosmolarity, human serum albumin, cholesterol, and transferrin had no significant effect on uptake or release. JF - Toxicology and applied pharmacology AU - Barton, J C AD - Veterans Administration Medical Center, Birmingham, Alabama. Y1 - 1989/06/15/ PY - 1989 DA - 1989 Jun 15 SP - 314 EP - 322 VL - 99 IS - 2 SN - 0041-008X, 0041-008X KW - Chelating Agents KW - 0 KW - Chloromercuribenzoates KW - Lead Radioisotopes KW - Lead KW - 2P299V784P KW - p-Chloromercuribenzoic Acid KW - 59-85-8 KW - Index Medicus KW - Chelating Agents -- pharmacology KW - Drug Interactions KW - Humans KW - In Vitro Techniques KW - Chloromercuribenzoates -- pharmacology KW - Erythrocytes -- drug effects KW - Erythrocytes -- metabolism KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79053695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Retention+of+radiolead+by+human+erythrocytes+in+vitro.&rft.au=Barton%2C+J+C&rft.aulast=Barton&rft.aufirst=J&rft.date=1989-06-15&rft.volume=99&rft.issue=2&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-25 N1 - Date created - 1989-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - "Eight-drugs-in-one-day" chemotherapy administered before and after radiotherapy to adult patients with malignant gliomas. AN - 78965610; 2720598 AB - Thirty-one adult patients with malignant glioma (23 with glioblastoma multiforme, six with anaplastic astrocytoma, and two with brainstem glioma) were treated with up to ten cycles of "eight-drugs-in-one-day" chemotherapy (methylprednisolone 300 mg/m2, vincristine 1.5 mg/m2 [maximum of 2 mg/cycle], CCNU 75 mg/m2, procarbazine 75 mg/m2, hydroxyurea 3000 mg/m2, cisplatin 90 mg/m2, cytosine arabinoside 300 mg/m2, and imidazole carboxamide 150 mg/m2). Chemotherapy was planned as two cycles before and eight cycles after 60 Gy of involved brain irradiation. A total of 117 cycles of chemotherapy was administered. There was one treatment-related death. Myelosuppression was the most frequent toxic effect (leucopenia was less than 1000/mm3 in 9% of cycles and 1000-2500/mm3 in 25%; thrombocytopenia was less than 100,000/mm3 in 33% of cycles). Sixteen patients developed infections requiring treatment, two of which were life-threatening. Five patients suffered ototoxicity. Nausea and vomiting were observed in 35% of patients. A reversible rise in creatinine was observed in five patients. One patient developed a severe motor neuropathy, and three patients developed mild peripheral neuropathies. Three patients had episodes of atrial fibrillation. One new bundle branch block with supraventricular tachycardia was observed in a patient with pulmonary embolus. Five patients developed thrombophlebitis, three of whom had pulmonary emboli. Two patients suffered strokes in areas anatomically separate from their tumor. Eleven patients declined to continue therapy after receiving an average of three cycles. Two had complete, and five had partial responses. The median survival time was 47 weeks. The responses and survival times observed are comparable to less toxic treatment protocols for adults with malignant gliomas. JF - Cancer AU - Rozental, J M AU - Robins, H I AU - Finlay, J AU - Healey, B AU - Levin, A B AU - Steeves, R A AU - Kohler, P C AU - Schutta, H S AU - Trump, D L AD - Neurology Service Wm. S. Middleton Memorial Veterans Administration Hospital, Madison, WI 53705. Y1 - 1989/06/15/ PY - 1989 DA - 1989 Jun 15 SP - 2475 EP - 2481 VL - 63 IS - 12 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Vascular Diseases -- chemically induced KW - Drug Administration Schedule KW - Bone Marrow Diseases -- chemically induced KW - Combined Modality Therapy KW - Humans KW - Tomography, X-Ray Computed KW - Aged KW - Hearing Loss -- chemically induced KW - Nervous System Diseases -- chemically induced KW - Adult KW - Body Weight -- drug effects KW - Middle Aged KW - Female KW - Male KW - Remission Induction KW - Brain Neoplasms -- blood KW - Brain Neoplasms -- therapy KW - Glioma -- therapy KW - Glioma -- diagnostic imaging KW - Glioma -- blood KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Brain Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78965610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=%22Eight-drugs-in-one-day%22+chemotherapy+administered+before+and+after+radiotherapy+to+adult+patients+with+malignant+gliomas.&rft.au=Rozental%2C+J+M%3BRobins%2C+H+I%3BFinlay%2C+J%3BHealey%2C+B%3BLevin%2C+A+B%3BSteeves%2C+R+A%3BKohler%2C+P+C%3BSchutta%2C+H+S%3BTrump%2C+D+L&rft.aulast=Rozental&rft.aufirst=J&rft.date=1989-06-15&rft.volume=63&rft.issue=12&rft.spage=2475&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-06 N1 - Date created - 1989-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatocellular carcinoma metastatic to the stomach presenting as bleeding multiple craterogenic ulcers. AN - 85220644; pmid-2543213 AB - A patient with previous resection of primary hepatocellular carcinoma developed upper intestinal bleeding. Pinch biopsy and needle aspiration biopsy of a submucosal antral lesion seen at endoscopy yielded metastatic hepatoma. We believe this to be the first report of the endoscopic appearance of a submucosal tumor. Currently available methods of tissue diagnosis are discussed. JF - The American Journal of Gastroenterology AU - Lynch, P AU - Green, L AU - Jordan, P H AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. PY - 1989 SP - 653 EP - 655 VL - 84 IS - 6 SN - 0002-9270, 0002-9270 KW - Stomach Ulcer KW - Carcinoma, Hepatocellular KW - Human KW - Peptic Ulcer Hemorrhage KW - Stomach Neoplasms KW - Aged KW - Case Report KW - Biopsy, Needle KW - Male KW - Liver Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85220644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Hepatocellular+carcinoma+metastatic+to+the+stomach+presenting+as+bleeding+multiple+craterogenic+ulcers.&rft.au=Lynch%2C+P%3BGreen%2C+L%3BJordan%2C+P+H%3BGraham%2C+D+Y&rft.aulast=Lynch&rft.aufirst=P&rft.date=1989-06-01&rft.volume=84&rft.issue=6&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Extended esophageal pH monitoring. An analysis of the literature and assessment of its role in the diagnosis and management of gastroesophageal reflux. AN - 85201591; pmid-2666499 AB - In this review article we examine several facets of extended pH monitoring of the esophagus. The different types of instrumentation and the technical difficulties of obtaining and interpreting tests are discussed. The wide variations among different laboratories in the duration and timing of pH monitoring sessions are summarized. We outline the problems in interpretation and reproducibility such as normal control values, criteria for separation of abnormal from normal subjects, correlation of pH events with symptoms and with esophageal injury. Comparison of extended with short-term monitoring of esophageal pH are drawn, as well as comparisons between results of extended monitoring and other tests of reflux. Cost considerations are listed. Finally, we present a proposed scheme for the use of extended pH monitoring as well as a cautious note about accepting extended pH monitoring as a routine clinical test at present. JF - Journal of Clinical Gastroenterology AU - Rosen, S N AU - Pope, C E AD - Division of Gastroenterology, Veterans Administration Medical Center, Seattle, WA 98108. PY - 1989 SP - 260 EP - 270 VL - 11 IS - 3 SN - 0192-0790, 0192-0790 KW - Esophagus KW - Comparative Study KW - Costs and Cost Analysis KW - Human KW - Hydrogen-Ion Concentration KW - Support, U.S. Gov't, Non-P.H.S. KW - Gastroesophageal Reflux KW - Monitoring, Physiologic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Extended+esophageal+pH+monitoring.+An+analysis+of+the+literature+and+assessment+of+its+role+in+the+diagnosis+and+management+of+gastroesophageal+reflux.&rft.au=Rosen%2C+S+N%3BPope%2C+C+E&rft.aulast=Rosen&rft.aufirst=S&rft.date=1989-06-01&rft.volume=11&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Age dependent alterations of host immune response in the ethanol-fed rat. AN - 79499938; 2632808 AB - The interaction between ethanol and aging with respect to cellular immune response is unclear. For our studies, Sprague-Dawley rats were pair fed using a synthetic liquid control diet (LCD) or a diet in which ethanol was substituted for carbohydrate (LED). The special diets were started when the rats' age varied from 1-18 months and were continued for one, two, or three months. In a second set of experiments, rats were treated continuously with these diets for 24 months. At each study period blood was drawn for serum and the spleen cells removed. Immune response was assessed by the lymphocyte transformation test using combinations of cells and serum from each of the rat groups. When LCD or LED were started in aged rats (18 months), after three months, there was a significant decrease in the Concanavalin A induced lymphocyte transformation test using the serum from LCD rats compared to serum from LED rats with either cells from LCD (1,273 +/- 831 (DPM +/- SD) vs 302 +/- 139; p less than 0.04) or cells from LED animals (984 +/- 338 vs 420 +/- 196; p less than 0.02). When the diet started at younger age or for less than three months these effects were not seen. In the continuously LCD or LED fed rats, the blastogenic response peaked at three months of treatment (four months of age) and decreased at six months and remained constant over the remainder of the 24 month period. There was no difference in lymphocyte DNA synthesis comparing any of the serum or cell groups with respect to diet.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of clinical & laboratory immunology AU - Roselle, G A AU - Mendenhall, C L AU - Grossman, C J AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 99 EP - 103 VL - 29 IS - 2 SN - 0141-2760, 0141-2760 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Lymphocyte Activation KW - Animals KW - Immunity, Cellular KW - Skin Tests KW - In Vitro Techniques KW - Spleen -- immunology KW - Male KW - Alcoholism -- immunology KW - Aging -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79499938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+%26+laboratory+immunology&rft.atitle=Age+dependent+alterations+of+host+immune+response+in+the+ethanol-fed+rat.&rft.au=Roselle%2C+G+A%3BMendenhall%2C+C+L%3BGrossman%2C+C+J&rft.aulast=Roselle&rft.aufirst=G&rft.date=1989-06-01&rft.volume=29&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+%26+laboratory+immunology&rft.issn=01412760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-23 N1 - Date created - 1990-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diazepam sensitizes mice to FG 7142 and reduces muscimol-stimulated 36Cl- flux. AN - 79306796; 2479037 AB - Chronic treatment with benzodiazepine receptor agonists increases sensitivity to the convulsant action of FG 7142, an inverse agonist. We investigated whether or not changes in the number and function of GABA-gated chloride channels accompanies this increased sensitivity. Diazepam, 5 mg.kg-1, was administered to mice daily for five days, and mice were then tested with a single injection of FG 7142, 40 mg.kg-1, at several intervals thereafter. At 24 hours after the last diazepam dose, 10 of 15 mice had clonic seizures following FG 7142 and four of the remaining five had myoclonic jerks. At 48 hours, only one of six mice developed a clonic seizure, and none were observed in mice tested at 96 or 144 hours. Muscimol-stimulated chloride flux was reduced in cortical synaptosomes from diazepam-treated mice at 24 hours but not at 48 or 96 hours. However, the binding of [35S]TBPS, a ligand closely associated with the chloride channel, was unchanged at 24 hours. These results suggest that a transient diminution in GABA-gated chloride channel function; unaccompanied by a reduction in channel number, may underlie the sensitization to the convulsant action of FG 7142 observed after withdrawal from chronic diazepam treatment. JF - Pharmacology, biochemistry, and behavior AU - Lewin, E AU - Peris, J AU - Bleck, V AU - Zahniser, N R AU - Harris, R A AD - Neurology and Research Services, Veterans Administration Medical Center, Denver, CO. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 465 EP - 468 VL - 33 IS - 2 SN - 0091-3057, 0091-3057 KW - Bridged Bicyclo Compounds KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - Carbolines KW - Chlorides KW - Ion Channels KW - Muscimol KW - 2763-96-4 KW - FG 7142 KW - 60PO70N1BP KW - tert-butylbicyclophosphorothionate KW - 70636-86-1 KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Mice KW - Bridged Bicyclo Compounds -- metabolism KW - Brain -- metabolism KW - Drug Synergism KW - Muscimol -- pharmacology KW - Kindling, Neurologic -- drug effects KW - Ion Channels -- drug effects KW - Diazepam -- pharmacology KW - Chlorides -- metabolism KW - Carbolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79306796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Diazepam+sensitizes+mice+to+FG+7142+and+reduces+muscimol-stimulated+36Cl-+flux.&rft.au=Lewin%2C+E%3BPeris%2C+J%3BBleck%2C+V%3BZahniser%2C+N+R%3BHarris%2C+R+A&rft.aulast=Lewin&rft.aufirst=E&rft.date=1989-06-01&rft.volume=33&rft.issue=2&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The goals of immunologic intervention in autoimmune disease. AN - 79209191; 2673275 AB - Autoimmune diseases represent disorders of immunologic regulation for which specifically targeted immunologic intervention offers great therapeutic promise, superior to highly toxic and totally non-specific conventional therapy currently in use. The cellular and cytokine targets for this new approach and the various concepts underlying their deployment are discussed in this article. JF - Journal of autoimmunity AU - Talal, N AD - Clinical Immunology Section, Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio, TX. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 257 EP - 264 VL - 2 Suppl SN - 0896-8411, 0896-8411 KW - Histocompatibility Antigens Class II KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - B-Lymphocytes -- immunology KW - T-Lymphocytes -- immunology KW - Immunosuppression KW - Immunotherapy KW - Autoimmune Diseases -- therapy KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79209191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+autoimmunity&rft.atitle=The+goals+of+immunologic+intervention+in+autoimmune+disease.&rft.au=Talal%2C+N&rft.aulast=Talal&rft.aufirst=N&rft.date=1989-06-01&rft.volume=2+Suppl&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+autoimmunity&rft.issn=08968411&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-17 N1 - Date created - 1989-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Influence of omega-3 and omega-6 fatty acid sources on prostaglandin levels in mice. AN - 79192100; 2770427 AB - Studies from this laboratory, employing a hairless mouse model, have indicated that a polyunsaturated fatty acid source rich in omega-3 (n-3) fatty acid (FA) inhibits ultraviolet (UV)-carcinogenic expression, when compared to that of diets containing predominantly n-6 fatty acids. Omega-3 FA is a poor substrate for cyclooxygenase, the rate-limiting step in prostaglandin (PG) synthesis--the latter, particularly PGE2, are known to influence tumor biology. Based upon this rationale, plasma and cutaneous PGE2 levels were determined from hairless mice fed diets containing either 4% or 12% corn or menhaden oil. After two weeks on the respective diets, plasma PGE2 levels of corn oil-fed animals were approximately 6-fold greater than those of the menhaden oil-fed groups. A similar response was found in the dermis. Although the relationship to carcinogenic expression is unknown, dietary n-3 FA content can have a pronounced effect upon PGE2 levels and possesses the potential for influencing other immunomodulators. JF - Lipids AU - Henderson, C D AU - Black, H S AU - Wolf, J E AD - Photobiology Laboratory, Veterans Administration Medical Center, Houston, Texas. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 502 EP - 505 VL - 24 IS - 6 SN - 0024-4201, 0024-4201 KW - Dietary Fats KW - 0 KW - Fatty Acids, Unsaturated KW - Fish Oils KW - Menhaden oil KW - 1D8HWC57D0 KW - Corn Oil KW - 8001-30-7 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Dose-Response Relationship, Drug KW - Skin -- metabolism KW - Neoplasms, Radiation-Induced -- prevention & control KW - Mice, Hairless -- radiation effects KW - Corn Oil -- pharmacology KW - Mice KW - Female KW - Fish Oils -- pharmacology KW - Dinoprostone -- blood KW - Dinoprostone -- biosynthesis KW - Fatty Acids, Unsaturated -- pharmacology KW - Dietary Fats -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79192100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Influence+of+omega-3+and+omega-6+fatty+acid+sources+on+prostaglandin+levels+in+mice.&rft.au=Henderson%2C+C+D%3BBlack%2C+H+S%3BWolf%2C+J+E&rft.aulast=Henderson&rft.aufirst=C&rft.date=1989-06-01&rft.volume=24&rft.issue=6&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-28 N1 - Date created - 1989-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents. AN - 79166940; 2504601 AB - Cilofungin (LY121019) was shown to have potent fungicidal activity against clinical isolates of Candida albicans and Candida tropicalis but not Candida parapsilosis. Fungicidal activity was evident against both replicating and non-replicating Candida albicans and was progressive over the first 12 h of incubation. The combination of cilofungin (LY121019) with anticapsin but not with amphotericin B, ketoconazole or 5-fluorocytosine resulted in synergistic fungicidal activity. This compound warrants further investigation of its safety and efficacy in the treatment of Candida infections. JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology AU - Pfaller, M AU - Gordee, R AU - Gerarden, T AU - Yu, M AU - Wenzel, R AD - Veterans Administration Medical Center, Iowa City, Iowa 52240. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 564 EP - 567 VL - 8 IS - 6 SN - 0934-9723, 0934-9723 KW - Antifungal Agents KW - 0 KW - Drug Combinations KW - Echinocandins KW - Peptides KW - Peptides, Cyclic KW - anticapsin KW - 75PQ0DZ8R2 KW - cilofungin KW - 8ZJC54A39X KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Kinetics KW - Humans KW - Drug Resistance, Microbial KW - Peptides -- pharmacology KW - Drug Synergism KW - Alanine -- analogs & derivatives KW - Candida -- drug effects KW - Antifungal Agents -- pharmacology KW - Alanine -- pharmacology KW - Candida albicans -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79166940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+microbiology+%26+infectious+diseases+%3A+official+publication+of+the+European+Society+of+Clinical+Microbiology&rft.atitle=Fungicidal+activity+of+cilofungin+%28LY121019%29+alone+and+in+combination+with+anticapsin+or+other+antifungal+agents.&rft.au=Pfaller%2C+M%3BGordee%2C+R%3BGerarden%2C+T%3BYu%2C+M%3BWenzel%2C+R&rft.aulast=Pfaller&rft.aufirst=M&rft.date=1989-06-01&rft.volume=8&rft.issue=6&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+microbiology+%26+infectious+diseases+%3A+official+publication+of+the+European+Society+of+Clinical+Microbiology&rft.issn=09349723&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Primidone/phenobarbital-induced periodic alternating nystagmus. AN - 79160753; 2764437 AB - A 37-year-old man with a history of seizures developed periodic alternating nystagmus (PAN) along with other signs of primidone/phenobarbital toxicity. The PAN gradually diminished in cycle length and intensity, finally resolving with gradual discontinuation of the drugs. JF - Annals of ophthalmology AU - Schwankhaus, J D AU - Kattah, J C AU - Lux, W E AU - Masucci, E F AU - Kurtzke, J F AD - Neurology Service, Veterans Administration Medical Center, Washington, DC. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 230 EP - 232 VL - 21 IS - 6 SN - 0003-4886, 0003-4886 KW - Primidone KW - 13AFD7670Q KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Eye Movements KW - Humans KW - Electronystagmography KW - Adult KW - Visual Acuity KW - Male KW - Phenobarbital -- adverse effects KW - Nystagmus, Pathologic -- chemically induced KW - Periodicity KW - Primidone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79160753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+ophthalmology&rft.atitle=Primidone%2Fphenobarbital-induced+periodic+alternating+nystagmus.&rft.au=Schwankhaus%2C+J+D%3BKattah%2C+J+C%3BLux%2C+W+E%3BMasucci%2C+E+F%3BKurtzke%2C+J+F&rft.aulast=Schwankhaus&rft.aufirst=J&rft.date=1989-06-01&rft.volume=21&rft.issue=6&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Annals+of+ophthalmology&rft.issn=00034886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-13 N1 - Date created - 1989-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of interaction between sulindac or naproxen and propranolol in hypertensive patients. AN - 79123691; 2666452 AB - Seventeen patients with hypertension and osteoarthritis participated in a single-blind crossover study comparing the effects of sulindac 200 mg twice daily, naproxen 500 mg twice daily, and placebo on blood pressure. All patients were treated for hypertension with propranolol monotherapy. Blood pressures were back-titrated to achieve a baseline diastolic blood pressure of 90 to 100 mm Hg while taking naproxen. There were no significant differences in mean sitting or standing blood pressures among the patients receiving naproxen, sulindac, or placebo treatments. There was no change in pulse, weight, or any of the laboratory measurements at the end of each treatment phase. These results suggest that neither sulindac nor naproxen interferes with propranolol therapy for uncomplicated hypertension. JF - Journal of clinical pharmacology AU - Schuna, A A AU - Vejraska, B D AU - Hiatt, J G AU - Kochar, M AU - Day, R AU - Goodfriend, T L AD - William S. Middleton Veterans Administration Medical Center, Madison, Wisconsin. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 524 EP - 528 VL - 29 IS - 6 SN - 0091-2700, 0091-2700 KW - Indenes KW - 0 KW - Sulindac KW - 184SNS8VUH KW - Naproxen KW - 57Y76R9ATQ KW - Sodium KW - 9NEZ333N27 KW - Propranolol KW - 9Y8NXQ24VQ KW - Creatinine KW - AYI8EX34EU KW - Renin KW - EC 3.4.23.15 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Drug Interactions KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Blood Urea Nitrogen KW - Pulse -- drug effects KW - Creatinine -- blood KW - Renin -- blood KW - Body Weight -- drug effects KW - Potassium -- blood KW - Middle Aged KW - Sodium -- blood KW - Blood Pressure -- drug effects KW - Propranolol -- therapeutic use KW - Indenes -- therapeutic use KW - Sulindac -- adverse effects KW - Hypertension -- physiopathology KW - Naproxen -- therapeutic use KW - Sulindac -- therapeutic use KW - Naproxen -- adverse effects KW - Propranolol -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79123691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Lack+of+interaction+between+sulindac+or+naproxen+and+propranolol+in+hypertensive+patients.&rft.au=Schuna%2C+A+A%3BVejraska%2C+B+D%3BHiatt%2C+J+G%3BKochar%2C+M%3BDay%2C+R%3BGoodfriend%2C+T+L&rft.aulast=Schuna&rft.aufirst=A&rft.date=1989-06-01&rft.volume=29&rft.issue=6&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-29 N1 - Date created - 1989-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Loss of muscarinic cholinergic receptors from the temporal cortex of alcohol abusers. AN - 79117635; 2547145 AB - It is currently controversial whether all the brain damage in alcohol abusers in the result of thiamine deficiency (Wernicke-Korsakoff's disease) or whether, in addition, alcohol abuse may affect the brain by other mechanisms as well. The purpose of this study was to determine if alcohol abuse affects muscarinic cholinergic and benzodiazepine receptors in histologically normal brains obtained at autopsy in a general hospital population. Patients were excluded from this study if they had clinical brain diseases (including Wernicke's disease), died in coma, or had liver disease, significant brain atrophy, or dementia severe enough to require institutionalization. We found that muscarinic cholinergic synaptic receptor density determined with [3H] quinuclidinly benzilate was decreased by 40% in homogenates of the tempeoral cortex of 26 alcohol abusers compared with 26 matched nonalcoholic controls. The affinities of the muscarinic receptors were not significantly different between the two groups. In contrast, receptor densities and affinities of benzodiazepine receptors determined with [3H]flunitrazepam were not significantly different in the two groups. Age and death-autopsy time interval had no significant effects on either wet tissue protein concentrations, yields of protein after centrifugation, or receptor binding. The contributions of age and time interval were each less than 2% of the total variance of protein concentrations and receptor binding. When patients were excluded or included who had received cholinergic, anticholinergic, or benzodiazepine medications before death, no significant effects on the final results were observed. Pneumonia, known to be associated with acute hypoxia, and chronic obstructive pulmonary disease, known to be associated with chronic hypoxia, where approximately equally distributed between the two groups and had no significant effects on the results reported here. The loss of muscarinic and the sparing of benzodiazepine receptors occurs in the temporal cortex of histologically normal brains in the absence of significant atrophy and of gross dementia. This means that these changes are early in the development of an alcohol encephalopathy. We have previously reported a decrease in both muscarinic and benzodiazepine receptor binding in the frontal cortex and a decreasing muscarinic but not benzodiazepine receptors in the temporal cortex of alcohol abusers. Taken together, these findings suggest that alcohol neurotoxicity does not simply result in a random loss of neurons and or their associated synapses with their receptors. Instead, different types of receptors, depending upon their location in different brain regions, are specifically affected or spared. This suggests the involvement of region- and receptor-specific mechanisms in chronic alcohol toxicity.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Metabolic brain disease AU - Freund, G AU - Ballinger, W E AD - Medical Service, Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 121 EP - 141 VL - 4 IS - 2 SN - 0885-7490, 0885-7490 KW - Receptors, GABA-A KW - 0 KW - Receptors, Muscarinic KW - Flunitrazepam KW - 620X0222FQ KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Index Medicus KW - Quinuclidinyl Benzilate -- metabolism KW - Postmortem Changes KW - Humans KW - Receptors, GABA-A -- metabolism KW - Aged KW - Middle Aged KW - Flunitrazepam -- metabolism KW - Temporal Lobe -- pathology KW - Temporal Lobe -- metabolism KW - Alcoholism -- metabolism KW - Receptors, Muscarinic -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79117635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolic+brain+disease&rft.atitle=Loss+of+muscarinic+cholinergic+receptors+from+the+temporal+cortex+of+alcohol+abusers.&rft.au=Freund%2C+G%3BBallinger%2C+W+E&rft.aulast=Freund&rft.aufirst=G&rft.date=1989-06-01&rft.volume=4&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Metabolic+brain+disease&rft.issn=08857490&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-29 N1 - Date created - 1989-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rhabdomyolysis detected by bone imaging. AN - 79087667; 2501052 AB - Rhabdomyolysis involves necrosis of skeletal muscle and may arise from multiple conditions both traumatic and nontraumatic. Bone imaging with Technetium-99m phosphates is a very sensitive indicator of acute muscle damage and may be used to visualize the extent of rhabdomyolysis and its resolution. A case of alcohol-induced rhabdomyolysis is presented. JF - Clinical nuclear medicine AU - Sanders, J A AD - Veterans Administration Medical Center, Jackson, Mississippi 39216. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 431 EP - 432 VL - 14 IS - 6 SN - 0363-9762, 0363-9762 KW - Index Medicus KW - Humans KW - Middle Aged KW - Whole-Body Counting KW - Alcoholism -- complications KW - Male KW - Radionuclide Imaging KW - Rhabdomyolysis -- etiology KW - Bone and Bones -- diagnostic imaging KW - Rhabdomyolysis -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79087667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=Rhabdomyolysis+detected+by+bone+imaging.&rft.au=Sanders%2C+J+A&rft.aulast=Sanders&rft.aufirst=J&rft.date=1989-06-01&rft.volume=14&rft.issue=6&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-21 N1 - Date created - 1989-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of starvation and refeeding on elastase-induced emphysema. AN - 79083671; 2526118 AB - Adult rats received pancreatic elastase (75 U/100 g) intratracheally and were divided into three groups: fed, starved, and refed. Starved rats received one-third of their measured daily food consumption until they lost 40% body weight. The refed group was fed after 40% weight loss. A control group received saline intratracheally. Saline volume-pressure curve was shifted more significantly to the left of the control group in starved than in fed rats and was superimposed in refed and fed groups. Mean linear intercept was larger and alveolar surface area was smaller in starved than in fed rats compared with the control group; both were similar in fed and refed rats. Protein and hydroxyproline content of the lung were higher in fed than in control and in starved groups; after refeeding these returned to the control values. We conclude that starvation aggravates elastase-induced injury and that refeeding results in the complete recovery of the mechanical but only partial recovery of the morphometric changes induced by starvation. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Sahebjami, H AU - Domino, M AD - Pulmonary Research Laboratory, Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 2611 EP - 2616 VL - 66 IS - 6 SN - 8750-7587, 8750-7587 KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Rats KW - Body Weight KW - Animals KW - Organ Size KW - Male KW - Pancreatic Elastase -- pharmacology KW - Lung -- anatomy & histology KW - Food KW - Pulmonary Emphysema -- chemically induced KW - Starvation -- physiopathology KW - Pulmonary Emphysema -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79083671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Effects+of+starvation+and+refeeding+on+elastase-induced+emphysema.&rft.au=Sahebjami%2C+H%3BDomino%2C+M&rft.aulast=Sahebjami&rft.aufirst=H&rft.date=1989-06-01&rft.volume=66&rft.issue=6&rft.spage=2611&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Second neoplasms in Hodgkin's disease: current controversies. AN - 79077858; 2663829 AB - Aggressive, multimodal treatment of Hodgkin's disease has led to dramatic increases in survival but not without significant early toxicity and late complications. The most serious late complication is the development of a secondary neoplasm. These secondary cancers include acute nonlymphocytic leukemia, non-Hodgkin's lymphoma, and various solid tumors. JF - Hematology/oncology clinics of North America AU - Zarrabi, M H AU - Rosner, F AD - Department of Medicine, Veterans Administration Medical Center, Northport, New York. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 303 EP - 318 VL - 3 IS - 2 SN - 0889-8588, 0889-8588 KW - Index Medicus KW - United States KW - Leukemia -- chemically induced KW - Neoplasms, Radiation-Induced -- etiology KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Neoplasms -- epidemiology KW - Aged KW - Combined Modality Therapy -- adverse effects KW - Child KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Italy KW - Child, Preschool KW - Infant KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Leukemia -- epidemiology KW - Neoplasms -- chemically induced KW - Adult KW - Lymphoma, Non-Hodgkin -- etiology KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Neoplasms, Multiple Primary -- etiology KW - Neoplasms, Multiple Primary -- epidemiology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Neoplasms, Multiple Primary -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Hodgkin Disease -- therapy KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79077858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology%2Foncology+clinics+of+North+America&rft.atitle=Second+neoplasms+in+Hodgkin%27s+disease%3A+current+controversies.&rft.au=Zarrabi%2C+M+H%3BRosner%2C+F&rft.aulast=Zarrabi&rft.aufirst=M&rft.date=1989-06-01&rft.volume=3&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Hematology%2Foncology+clinics+of+North+America&rft.issn=08898588&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aggravation of salt-induced hypertension in Dahl rats by 2% supplemental dietary calcium. AN - 79070691; 2567707 AB - There is considerable interest in the antihypertensive potential of supplemental dietary calcium in salt-sensitive hypertension. Previously we reported that very high dietary calcium (4.0% vs. 0.4%) lowers mean arterial pressure in Dahl salt-sensitive (DS) hypertensive rats. However, we have recently observed that more moderate calcium supplementation (2.0% vs. 0.4%) increases mean arterial pressure in DS rats. To further evaluate the pressor action of 2.0% versus 0.4% calcium, we tested for effects of 2.0% calcium in female DS rats fed low (0.2%), moderate (1.0%), and high (2.7%) sodium and in Dahl salt-resistant (DR) rats fed high sodium from 6 to 12 weeks old (n = 10-13 rats per group). At 12 weeks, 2.0% calcium increased mean arterial pressure and the cardiac ventricular weight/body weight ratio in DS rats fed high sodium (p less than 0.05) but not in DS rats fed low or moderate sodium or in DR rats fed high sodium. Ganglionic blockade decreased mean arterial pressure in all groups but failed to abolish or attenuate the difference in mean arterial pressure between high sodium-fed DS rats on 2.0% and 0.4% calcium diets. In the same DS rats fed a high sodium diet, 2.0% calcium increased systemic pressor responsiveness to graded norepinephrine administration after ganglionic blockade. Thus, 2.0% supplemental calcium intake enhances salt-induced hypertension in DS rats. This prohypertensive action of 2.0% calcium is dependent on a critically high level of between 1.0% and 2.7% sodium in the diet.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hypertension (Dallas, Tex. : 1979) AU - Peuler, J D AU - Mark, A L AD - Veterans Administration Medical Center, Iowa City, IA 52240. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 929 EP - 934 VL - 13 IS - 6 Pt 2 SN - 0194-911X, 0194-911X KW - Calcium, Dietary KW - 0 KW - Ganglionic Blockers KW - Sodium Chloride KW - 451W47IQ8X KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats KW - Animals KW - Ganglionic Blockers -- pharmacology KW - Rats, Mutant Strains KW - Norepinephrine -- pharmacology KW - Drug Resistance KW - Blood Pressure -- drug effects KW - Female KW - Hypertension -- chemically induced KW - Hypertension -- blood KW - Calcium, Dietary -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79070691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Aggravation+of+salt-induced+hypertension+in+Dahl+rats+by+2%25+supplemental+dietary+calcium.&rft.au=Peuler%2C+J+D%3BMark%2C+A+L&rft.aulast=Peuler&rft.aufirst=J&rft.date=1989-06-01&rft.volume=13&rft.issue=6+Pt+2&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-08 N1 - Date created - 1989-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interleukin-2 induced mitogenesis of human peripheral blood T-lymphocytes: role of accessory cells. AN - 79062714; 2786845 AB - We and others have shown that interleukin-2 (IL-2) is mitogenic to a subset of unstimulated T lymphocytes in human peripheral blood (1-7). We extend our work here in showing that prolonged continuous exposure of human peripheral blood lymphocytes to exogenous IL-2 throughout the 7-8 day culture is not necessary since mitogenesis occurs reproducibly after short term (2-3 hr) pulse exposure. The mitogenic effect of pulse exposure to IL-2 is not significantly reduced by inclusion of anti-Tac monoclonal antibody in the pulsing medium. However, anti-Tac monoclonal antibody markedly inhibits the response if present continuously throughout the 7 day culture. The mitogenic effect of IL-2 is dependent on the presence of accessory cells (monocytes) but the accessory cell requirement can be replaced by the phorbol ester TPA (10(-8 to 10(-11) M). Purified monocytes subjected to short term pulse exposure to IL-2 can cause proliferative response in unprimed autologous lymphocytes in co-cultures. The mitogenic effect of IL-2 pulsed monocytes can not be suppressed by inclusion of anti-Tac antibody in the pulsing medium although the same concentration of the antibody suppresses the effect if present throughout culture. The response of lymphocytes to IL-2 pulsed monocytes is not inhibitable by the continuous presence of a monoclonal antibody to human HLA-DR antigens (OK-Ia1) in culture. JF - Immunological investigations AU - Mookerjee, B K AU - Pauly, J L AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, New York. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 697 EP - 711 VL - 18 IS - 5 SN - 0882-0139, 0882-0139 KW - Antibodies, Monoclonal KW - 0 KW - Interleukin-2 KW - Phorbol Esters KW - Index Medicus KW - Phorbol Esters -- metabolism KW - Cells, Cultured KW - Humans KW - Monocytes -- metabolism KW - Time Factors KW - Interleukin-2 -- pharmacology KW - T-Lymphocytes -- metabolism KW - Antigen-Presenting Cells -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79062714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+investigations&rft.atitle=Interleukin-2+induced+mitogenesis+of+human+peripheral+blood+T-lymphocytes%3A+role+of+accessory+cells.&rft.au=Mookerjee%2C+B+K%3BPauly%2C+J+L&rft.aulast=Mookerjee&rft.aufirst=B&rft.date=1989-06-01&rft.volume=18&rft.issue=5&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Immunological+investigations&rft.issn=08820139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanism of ranitidine associated anemia. AN - 79056860; 2735342 AB - Ranitidine, an H2 receptor antagonist, has been associated with hematotoxicity. The mechanism(s) underlying the toxicity is not well understood. The authors studied the mechanism of anemia in a patient with ranitidine associated anemia and thrombocytopenia. Clinical evaluation suggested drug-induced Coombs' positive reticulocytopenic hemolysis. In vitro, with the patient off ranitidine, the authors were able to induce Coombs' positivity by incubating patient's red cells with ranitidine and his serum. This process was inhibited by prior exposure of his red cells to histamine. In vitro studies using clonal assays for hematopoietic progenitors revealed that while the patient's serum or ranitidine alone did not affect the patient's or normal bone marrow hematopoiesis, the simultaneous presence of both agents significantly suppressed both patient's and normal erythroid progenitor (BFU-E) colony development. This suppressive effect was prevented by the prior exposure of marrow to histamine and was not observed when the patient's serum was heat inactivated. These studies suggest that the anemia may have resulted from complement-dependent autoimmune destruction/inhibition of progenitor/mature erythroid cells by a process critically dependent on the presence of ranitidine and possibly acting at or near the histamine receptor. JF - The American journal of the medical sciences AU - Pixley, J S AU - MacKintosh, F R AU - Sahr, E A AU - Zanjani, E D AD - Veterans Administration Medical Center, University of Nevada School of Medicine, Reno 89520. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 369 EP - 371 VL - 297 IS - 6 SN - 0002-9629, 0002-9629 KW - Histamine KW - 820484N8I3 KW - Ranitidine KW - 884KT10YB7 KW - Abridged Index Medicus KW - Index Medicus KW - Erythrocytes -- drug effects KW - Bone Marrow -- pathology KW - Histamine -- pharmacology KW - Humans KW - In Vitro Techniques KW - Coombs Test KW - Thrombocytopenia -- chemically induced KW - Middle Aged KW - Bone Marrow -- drug effects KW - Male KW - Erythrocytes -- immunology KW - Hematopoietic Stem Cells -- drug effects KW - Ranitidine -- antagonists & inhibitors KW - Anemia -- blood KW - Anemia -- chemically induced KW - Anemia -- immunology KW - Ranitidine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79056860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Mechanism+of+ranitidine+associated+anemia.&rft.au=Pixley%2C+J+S%3BMacKintosh%2C+F+R%3BSahr%2C+E+A%3BZanjani%2C+E+D&rft.aulast=Pixley&rft.aufirst=J&rft.date=1989-06-01&rft.volume=297&rft.issue=6&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-18 N1 - Date created - 1989-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathogenesis of duodenal ulcer in the rat: dissociation of acid load and blood flow. AN - 79051832; 2735411 AB - Duodenal mucosal blood flow (DMBF) and duodenal acid load were studied in nonanesthetized rats. Four groups of animals were injected with an ulcerogenic dose of mepirizole [1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole] and were studied at 3, 6, 12, and 24 h after drug administration. Three additional groups were given an injection of the vehicle used to solubilize the drug and were studied 3, 12, and 24 h later. All animals studied 24 h after mepirizole showed ulceration of the proximal duodenum. DMBF in animals that received vehicle averaged 141 +/- 12 ml.100 g-1.min-1. A significant duodenal hyperemia was observed 3 and 6 h after mepirizole (498 +/- 113 and 377 +/- 92 ml.100 g-1.min-1, respectively). A large increase in duodenal acid load was also found at these times (47.6 +/- 2.6 and 46.4 +/- 7.3 mueq/h, respectively). DMBF declined progressively afterwards to reach subnormal levels at 24 h after mepirizole. Acid load, however, remained at a high level throughout the 24 h of observation. In contrast, no significant changes in blood flow were observed in pancreas, jejunum, ileum, or colon. In animals with a duodenal ligature 5 mm distal to the pylorus, a hyperemia was observed in the portion of duodenum in continuity with the stomach. This phenomenon was absent in the duodenum distal to the ligature. It is concluded that the high duodenal acid load observed in the face of decreasing DMBF could explain the occurrence of duodenal damage between 12 and 24 h after mepirizole administration. JF - The American journal of physiology AU - Scremin, O U AU - Leung, F W AU - Guth, P H AD - Veterans Administration Medical Center, Albuquerque, New Mexico 87108. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - G1058 EP - G1062 VL - 256 IS - 6 Pt 1 SN - 0002-9513, 0002-9513 KW - Epirizole KW - 3B46O2FH8I KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Hydrogen-Ion Concentration KW - Regional Blood Flow -- drug effects KW - Epirizole -- toxicity KW - Blood Pressure -- drug effects KW - Male KW - Duodenum -- drug effects KW - Duodenal Ulcer -- chemically induced KW - Duodenal Ulcer -- physiopathology KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - Intestinal Mucosa -- blood supply KW - Duodenum -- blood supply KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79051832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Pathogenesis+of+duodenal+ulcer+in+the+rat%3A+dissociation+of+acid+load+and+blood+flow.&rft.au=Scremin%2C+O+U%3BLeung%2C+F+W%3BGuth%2C+P+H&rft.aulast=Scremin&rft.aufirst=O&rft.date=1989-06-01&rft.volume=256&rft.issue=6+Pt+1&rft.spage=G1058&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-18 N1 - Date created - 1989-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Codeine addiction. AN - 79050182; 2741482 JF - DICP : the annals of pharmacotherapy AU - Rowden, A M AU - Lopez, J R AD - Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 475 EP - 477 VL - 23 IS - 6 SN - 1042-9611, 1042-9611 KW - Codeine KW - Q830PW7520 KW - Index Medicus KW - Humans KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79050182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DICP+%3A+the+annals+of+pharmacotherapy&rft.atitle=Codeine+addiction.&rft.au=Rowden%2C+A+M%3BLopez%2C+J+R&rft.aulast=Rowden&rft.aufirst=A&rft.date=1989-06-01&rft.volume=23&rft.issue=6&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=DICP+%3A+the+annals+of+pharmacotherapy&rft.issn=10429611&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-04 N1 - Date created - 1989-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A fatal attraction: cocaine related subarachnoid hemorrhage. AN - 79043492; 2525157 AB - An alarming number of people use cocaine, a drug surrounded with myths and misconceptions. Cocaine use is associated with many medical and psychiatric problems. It is now believed cocaine use may lead to subarachnoid hemorrhage. Cocaine stimulates the release of various neurotransmitters in the brain as well as blocks their uptake, causing a temporary surge in systolic blood pressure. The constant assault on the vessels from continuous cocaine use weakens them causing hemorrhage or possibly creates an aneurysm. This article explains how cocaine affects the blood vessels and neurotransmitters of the brain, reviews two case histories in which cocaine may have contributed to aneurysmal formation and subarachnoid hemorrhage and discusses nursing implications of cocaine related subarachnoid hemorrhage. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Willis, D AU - Harbit, M D AD - Veterans Administration Medical Center, Iowa City, IA 52246. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 171 EP - 174 VL - 21 IS - 3 SN - 0888-0395, 0888-0395 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Nursing KW - Humans KW - Adult KW - Male KW - Substance-Related Disorders -- physiopathology KW - Subarachnoid Hemorrhage -- nursing KW - Subarachnoid Hemorrhage -- chemically induced KW - Subarachnoid Hemorrhage -- physiopathology KW - Substance-Related Disorders -- complications KW - Cocaine -- pharmacology KW - Cocaine -- adverse effects KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79043492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=A+fatal+attraction%3A+cocaine+related+subarachnoid+hemorrhage.&rft.au=Willis%2C+D%3BHarbit%2C+M+D&rft.aulast=Willis&rft.aufirst=D&rft.date=1989-06-01&rft.volume=21&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-24 N1 - Date created - 1989-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cognitive impairment following frontal lobe damage and its relevance to human amnesia. AN - 79036060; 2736069 AB - Whether frontal lobe pathology can account for some of the cognitive impairment observed in amnesic patients with Korsakoff's syndrome was investigated. Various cognitive and memory tests were given to patients with circumscribed frontal lobe lesions, patients with Korsakoff's syndrome, non-Korsakoff amnesic patients, and control Ss. Patients with frontal lobe lesions were not amnesic. Nevertheless they exhibited 2 deficits that were also exhibited by patients with Korsakoff's syndrome but not by other amnesic patients: (a) impairment on the Wisconsin Card Sorting Test and (b) impairment on the Initiation and Preservation subscale of the Dementia Rating Scale. Thus, frontal lobe pathology can explain some of the cognitive deficits observed in patients with Korsakoff's syndrome. JF - Behavioral neuroscience AU - Janowsky, J S AU - Shimamura, A P AU - Kritchevsky, M AU - Squire, L R AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 548 EP - 560 VL - 103 IS - 3 SN - 0735-7044, 0735-7044 KW - Index Medicus KW - Proactive Inhibition -- physiology KW - Alcohol Amnestic Disorder -- physiopathology KW - Humans KW - Aged KW - Verbal Learning -- physiology KW - Intelligence -- physiology KW - Brain Mapping KW - Mental Recall -- physiology KW - Adult KW - Middle Aged KW - Neuropsychological Tests KW - Female KW - Male KW - Frontal Lobe -- physiopathology KW - Brain Damage, Chronic -- physiopathology KW - Amnesia -- physiopathology KW - Cognition Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79036060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Cognitive+impairment+following+frontal+lobe+damage+and+its+relevance+to+human+amnesia.&rft.au=Janowsky%2C+J+S%3BShimamura%2C+A+P%3BKritchevsky%2C+M%3BSquire%2C+L+R&rft.aulast=Janowsky&rft.aufirst=J&rft.date=1989-06-01&rft.volume=103&rft.issue=3&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-10 N1 - Date created - 1989-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal. AN - 79035639; 2472177 AB - Thirty-two male DSM-III diagnosed schizophrenic patients received a lumbar puncture (LP) during chronic haloperidol treatment that was followed by replacement with placebo for up to 6 weeks. Fourteen patients relapsed on placebo within 6 weeks. Patients received a second LP at the time of relapse or at the end of 6 weeks if they had not relapsed. Bunney-Hamburg Global Psychosis Ratings of the day and the hours of sleep of the night before the LP were obtained, as were the Brief Psychiatric Ratings Scale (BPRS) ratings during the week of the LPs. CSF norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5 HIAA) concentrations were measured with high-pressure liquid chromatography (HPLC). Patients who relapsed had significantly higher CSF NE levels on and off haloperidol than patients who did not relapse. CSF MHPG was higher in the relapsers in the drug-free condition only, but CSF HVA and 5-HIAA were not significantly different in either condition. In the drug-free relapsed patients, CSF NE correlated significantly with the psychosis ratings of the day and hours of sleep the night prior to the LP. Our data indicate that elevated CSF NE levels during neuroleptic treatment may predict behavioral decompensation after discontinuing the medication. JF - Biological psychiatry AU - van Kammen, D P AU - Peters, J AU - van Kammen, W B AU - Nugent, A AU - Goetz, K L AU - Yao, J AU - Linnoila, M AD - Veterans Administration Medical Center, Pittsburgh, PA 15206. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 176 EP - 188 VL - 26 IS - 2 SN - 0006-3223, 0006-3223 KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Haloperidol KW - J6292F8L3D KW - Norepinephrine KW - X4W3ENH1CV KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Homovanillic Acid -- cerebrospinal fluid KW - Psychiatric Status Rating Scales KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Risk Factors KW - Humans KW - Adult KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Chronic Disease KW - Recurrence KW - Male KW - Chromatography, High Pressure Liquid KW - Haloperidol -- adverse effects KW - Haloperidol -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Substance Withdrawal Syndrome -- cerebrospinal fluid KW - Schizophrenia -- cerebrospinal fluid KW - Norepinephrine -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79035639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=CSF+norepinephrine+in+schizophrenia+is+elevated+prior+to+relapse+after+haloperidol+withdrawal.&rft.au=van+Kammen%2C+D+P%3BPeters%2C+J%3Bvan+Kammen%2C+W+B%3BNugent%2C+A%3BGoetz%2C+K+L%3BYao%2C+J%3BLinnoila%2C+M&rft.aulast=van+Kammen&rft.aufirst=D&rft.date=1989-06-01&rft.volume=26&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-01 N1 - Date created - 1989-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Response of rat inner medullary collecting duct to epidermal growth factor. AN - 79034154; 2544106 AB - Urine is an abundant source of epidermal growth factor (EGF) and prepro-EGF has been localized to the thick ascending limb and distal convoluted tubule of the kidney. However, the functional role of EGF in the kidney is poorly understood. Determination of EGF receptors and functional responses to EGF in intrarenal structures distal to the site of renal EGF production may prove critical to our understanding of the role of this peptide. These studies were designed to investigate the response to EGF of rat inner medullary collecting duct cells in culture and in freshly isolated suspensions. Primary cultures of inner medullary collecting duct cells demonstrated equilibrium binding of 125I-labeled EGF at 4 and 23 degrees C. At 23 degrees C, there was 89 +/- 1% specific binding (n = 30). Scatchard analysis of 125I-EGF binding suggested the presence of both high-affinity binding with a dissociation constant (Kd) of 5 X 10(-10) M and maximal binding sites (Ro) of 2.7 X 10(3) binding sites/cell and low-affinity binding, with Kd of 8.3 X 10(-9) M and Ro of 1.8 X 10(4) binding sites/cell. Bound EGF, 68 +/- 3%, was internalized by 45 min. EGF binding was not inhibited by antidiuretic hormone, atrial natriuretic peptide or bradykinin at 23 degrees C, but there was concentration-dependent inhibition of binding by transforming growth factor-alpha. Incubation with phorbol myristate acetate decreased 125I-EGF binding in a concentration-dependent manner. 125I-EGF binding was also demonstrated in freshly isolated suspensions of rat inner medullary collecting duct cells.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of physiology AU - Harris, R C AD - Department of Medicine, Veterans Administration Medical Center, Nashville, Tennessee. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - F1117 EP - F1124 VL - 256 IS - 6 Pt 2 SN - 0002-9513, 0002-9513 KW - Arachidonic Acids KW - 0 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cyclic AMP KW - E0399OZS9N KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dinoprostone -- biosynthesis KW - Cells, Cultured KW - Kinetics KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Arachidonic Acids -- metabolism KW - Male KW - Kidney Tubules, Collecting -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Kidney Medulla -- metabolism KW - Kidney Tubules, Collecting -- drug effects KW - Kidney Medulla -- drug effects KW - Kidney Tubules -- metabolism KW - Epidermal Growth Factor -- pharmacology KW - Epidermal Growth Factor -- metabolism KW - DNA Replication -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79034154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Response+of+rat+inner+medullary+collecting+duct+to+epidermal+growth+factor.&rft.au=Harris%2C+R+C&rft.aulast=Harris&rft.aufirst=R&rft.date=1989-06-01&rft.volume=256&rft.issue=6+Pt+2&rft.spage=F1117&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-18 N1 - Date created - 1989-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Blockade by lipoxygenase inhibitors of Ca2+-dependent insulin secretion from permeabilized rat islets. A molecular mechanism distinct from that of alpha 2-adrenergic agonists. AN - 79027056; 2567595 AB - To evaluate the regulation and effects of pancreatic islet lipoxygenase, adult rat islets were permeabilized, using digitonin or staphylococcal alpha-toxin, and then were studied in a medium simulating an intracellular milieu at fixed ambient concentrations of Ca2+. Permeabilized islets retained 12-lipoxygenase activity, as indicated by conversion of tritiated arachidonic acid to a predominant peak of [3H]12-hydroxyeicosatetraenoic acid (12-HETE); this activity was inhibited (89-98%) by the lipoxygenase blockers nordihydroguaiaretic acid (35 microM), BW755c (250 microM) or ETYA (35 microM). Lesser amounts of compounds coeluting with 15- and 11-HETE (but little or no 5-HETE) were formed; however, 11-HETE (and possibly some 15-HETE) was probably synthesized (at least in part) via cyclooxygenase, as suggested by the partial synthesis blockade induced by 50 microM ibuprofen. The production of 12-HETE did not require the presence of Ca2+, Mg2+ or ATP; it also was not stimulated by addition of cyclic AMP, a phorbol ester, or calmodulin. However, it was augmented modestly by provision of a basal cytosolic free Ca2+ concentration of 60-80 nM, with no further increase at physiologically elevated levels of 260-530 nM. Elevations in cytosolic free Ca2+ concentrations induced insulin release which was inhibited by cooling, epinephrine or protein kinase inhibitors and, therefore, was exocytotic in nature. Lipoxygenase inhibitors blocked this insulinotropic effect of calcium at submaximal or saturating Ca2+ concentrations (with or without its potentiation by 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C) by 53-82%. However, they did not reduce the Ca2+-independent secretory effects (at subnanomolar Ca2+ concentrations) of the phorbol ester alone. Similar results were seen using dibutyryl cyclic AMP to activate protein kinase A. The alpha 2-adrenergic agonists epinephrine or clonidine inhibited Ca2+-, TPA- or cyclic AMP-induced insulin release without reducing HETE formation. We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Biochemical pharmacology AU - Metz, S A AD - Medicine Service, Denver Veterans Administration Medical Center, CO 80220. Y1 - 1989/06/01/ PY - 1989 DA - 1989 Jun 01 SP - 1849 EP - 1862 VL - 38 IS - 11 SN - 0006-2952, 0006-2952 KW - Adrenergic alpha-Antagonists KW - 0 KW - Hydroxyeicosatetraenoic Acids KW - Insulin KW - Lipoxygenase Inhibitors KW - Pyrazoles KW - 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine KW - 66000-40-6 KW - Masoprocol KW - 7BO8G1BYQU KW - Lipoxygenase KW - EC 1.13.11.12 KW - Magnesium KW - I38ZP9992A KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Secretory Rate -- drug effects KW - Pyrazoles -- pharmacology KW - Magnesium -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Membrane Permeability KW - Hydroxyeicosatetraenoic Acids -- metabolism KW - Masoprocol -- pharmacology KW - Adrenergic alpha-Antagonists -- pharmacology KW - Lipoxygenase -- metabolism KW - Calcium -- physiology KW - Insulin -- secretion KW - Islets of Langerhans -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79027056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Blockade+by+lipoxygenase+inhibitors+of+Ca2%2B-dependent+insulin+secretion+from+permeabilized+rat+islets.+A+molecular+mechanism+distinct+from+that+of+alpha+2-adrenergic+agonists.&rft.au=Metz%2C+S+A&rft.aulast=Metz&rft.aufirst=S&rft.date=1989-06-01&rft.volume=38&rft.issue=11&rft.spage=1849&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-20 N1 - Date created - 1989-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. AN - 79025593; 2567350 AB - Simultaneous action of morphine on supraspinal and spinal sites produces a multiplicative interaction for antinociception which may be important for the analgesia produced by systemically administered morphine. The purpose of this study was to see whether other agonists with more receptor selective opioid actions than morphine would also produce this multiplicative interaction. DAMPGO (Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5), DPDPE (D-Pen2, D-Pen5, enkephalin) and U50-488H, opioid agonists highly selective for mu, delta and kappa receptors, respectively, were administered alone i.c.v. or intrathecally (i.t.) or in combination (i.c.v. plus i.t.) to determine ED50 values for the tail-flick response in mice. These ED50 values were examined isobolographically in relation to the theoretical additive ED50 values by the potency ratio method. First, DAMPGO given i.cv and i.t. was similar to morphine, indicating that simultaneous supraspinal and spinal mu agonist administration produce the multiplicative interaction. Second, concurrent administration of DPDPE or U50,488H, i.c.v. and i.t., as well as cross-over combinations of DPDPE at one and U50,488H at the other site, produced additive interactions only. The multiplicative interaction was a property characteristic of mu but not delta and kappa agonists. Based on the similarity between morphine and DAMPGO, it was postulated that both mu agonists act on redundant descending pain inhibitory pathways to produce multiplication. A second mechanism for multiplicative interaction was based on the difference between DAMPGO and morphine.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Roerig, S C AU - Fujimoto, J M AD - Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 762 EP - 768 VL - 249 IS - 3 SN - 0022-3565, 0022-3565 KW - Analgesics, Opioid KW - 0 KW - Enkephalins KW - Pyrrolidines KW - Receptors, Opioid KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer KW - 67198-13-4 KW - Morphine KW - 76I7G6D29C KW - Enkephalin, D-Penicillamine (2,5)- KW - 88373-73-3 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Injections, Spinal KW - Mice KW - Morphine -- administration & dosage KW - Drug Synergism KW - Male KW - Morphine -- pharmacology KW - Injections, Intraventricular KW - Pyrrolidines -- administration & dosage KW - Enkephalins -- pharmacology KW - Enkephalins -- administration & dosage KW - Analgesics, Opioid -- pharmacology KW - Receptors, Opioid -- drug effects KW - Pyrrolidines -- pharmacology KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79025593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Multiplicative+interaction+between+intrathecally+and+intracerebroventricularly+administered+mu+opioid+agonists+but+limited+interactions+between+delta+and+kappa+agonists+for+antinociception+in+mice.&rft.au=Roerig%2C+S+C%3BFujimoto%2C+J+M&rft.aulast=Roerig&rft.aufirst=S&rft.date=1989-06-01&rft.volume=249&rft.issue=3&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-21 N1 - Date created - 1989-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both. AN - 79023941; 2658581 AB - Lower extremity infections in the presence vascular insufficiency are difficult and costly to treat. Few well-controlled clinical trials evaluating the management of these infections exist. We decided to investigate the ability of a new fluoroquinolone, ciprofloxacin, to reduce the morbidity associated with these infections and the amount of in-hospital time required for the administration of antibiotic therapy. Forty-eight patients with peripheral vascular disease (46 with diabetes mellitus) who presented to the hospital for treatment of lower extremity infections were randomized in a blinded fashion to receive oral ciprofloxacin at a dosage of either 750 mg or 1,000 mg twice daily. Patients with osteomyelitis received three months of therapy and those with infections limited to soft tissues, three weeks of ciprofloxacin treatment. All subjects were followed for one year. One patient received an amputation 24 hours after enrollment, and two patients discontinued therapy after 20 and 34 days because of adverse effects and were not evaluable. At the one-year follow-up, 27 of the 45 (60 percent) evaluable patients had a fully successful outcome defined as not requiring either repeat antimicrobial therapy for their initial infection or amputation of the involved extremity. In the group of 18 patients in whom therapy failed, a total of only nine amputations were required. In the 15 patients whose lesion closed during therapy, 93% (14 patients) experienced a long-term successful outcome. Treatment with this new fluoroquinolone offers promise for the improved outcome of patients with the serious infectious complication of infected lower extremity ulcerations in peripheral vascular disease, diabetes mellitus, or both. JF - The American journal of medicine AU - Peterson, L R AU - Lissack, L M AU - Canter, K AU - Fasching, C E AU - Clabots, C AU - Gerding, D N AD - Medical Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 801 EP - 808 VL - 86 IS - 6 Pt 2 SN - 0002-9343, 0002-9343 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Abridged Index Medicus KW - Index Medicus KW - Diabetes Mellitus -- microbiology KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Bacteria -- isolation & purification KW - Bacteria -- drug effects KW - Microbial Sensitivity Tests KW - Male KW - Female KW - Venous Insufficiency -- complications KW - Bacterial Infections -- etiology KW - Bacterial Infections -- microbiology KW - Ciprofloxacin -- adverse effects KW - Ciprofloxacin -- pharmacology KW - Ciprofloxacin -- administration & dosage KW - Ciprofloxacin -- pharmacokinetics KW - Diabetic Angiopathies -- microbiology KW - Leg Ulcer -- complications KW - Leg Ulcer -- drug therapy KW - Venous Insufficiency -- microbiology KW - Leg Ulcer -- microbiology KW - Diabetic Angiopathies -- complications KW - Bacterial Infections -- drug therapy KW - Diabetes Complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79023941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Therapy+of+lower+extremity+infections+with+ciprofloxacin+in+patients+with+diabetes+mellitus%2C+peripheral+vascular+disease%2C+or+both.&rft.au=Peterson%2C+L+R%3BLissack%2C+L+M%3BCanter%2C+K%3BFasching%2C+C+E%3BClabots%2C+C%3BGerding%2C+D+N&rft.aulast=Peterson&rft.aufirst=L&rft.date=1989-06-01&rft.volume=86&rft.issue=6+Pt+2&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-06 N1 - Date created - 1989-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of ventricular arrhythmia by high and low osmolarity ionic and nonionic contrast media. AN - 79016444; 2471401 AB - Studies that used prolonged contrast media infusion in canine arteries have generated controversy regarding the arrhythmogenic potential of low osmolarity, nonionic contrast agents. In order to establish the relative safety of these agents in the more typical setting of bolus injections, 4 ml intracoronary bolus injections of Hypaque-76 (n = 54), Iohexol-350 (n = 51), and Iohexol-140 (n = 51) were given in random order to 10 anesthetized, open-chest dogs undergoing programmed cardiac stimulation. Hemodynamics and electrocardiogram were monitored during stimulation, both during and for 2 minutes after the end of contrast infusion. Occurrence of evoked single and coupled premature ventricular contractions and nonsustained ventricular tachycardia did not differ statistically among agents. Sustained ventricular tachycardia (five episodes) and ventricular fibrillation (seven episodes) occurred only after Hypaque-76 injections (p less than 0.002). These results differ from those in studies that use continuous contrast infusion and suggest that low osmolarity nonionic contrast agents are as safe as high osmolarity nonionic contrast media. Both appear safer than ionic contrast material. JF - American heart journal AU - Pinto, I M AU - Kou, W H AU - McGillem, M J AU - DeBoe, S F AU - Mickelson, J K AU - Mancini, G B AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, MI 48105. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 1283 EP - 1287 VL - 117 IS - 6 SN - 0002-8703, 0002-8703 KW - Diatrizoate KW - 117-96-4 KW - Iohexol KW - 4419T9MX03 KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Cardiac Complexes, Premature -- chemically induced KW - Animals KW - Ventricular Fibrillation -- chemically induced KW - Electrocardiography KW - Dogs KW - Tachycardia -- chemically induced KW - Arrhythmias, Cardiac -- chemically induced KW - Iohexol -- toxicity KW - Diatrizoate -- toxicity KW - Arrhythmias, Cardiac -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79016444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Induction+of+ventricular+arrhythmia+by+high+and+low+osmolarity+ionic+and+nonionic+contrast+media.&rft.au=Pinto%2C+I+M%3BKou%2C+W+H%3BMcGillem%2C+M+J%3BDeBoe%2C+S+F%3BMickelson%2C+J+K%3BMancini%2C+G+B&rft.aulast=Pinto&rft.aufirst=I&rft.date=1989-06-01&rft.volume=117&rft.issue=6&rft.spage=1283&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-05 N1 - Date created - 1989-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of coronary artery disease in the patient unable to exercise: alternatives to exercise stress testing. AN - 79007523; 2567110 AB - Exercise stress testing is a well-established method for the diagnostic, prognostic, and functional assessment of patients with known or suspected CAD. A variety of alternative tests have been described in patients unable to perform leg exercise. Atrial pacing and dipyridamole imaging have been evaluated most extensively, and results compare favorably with those of exercise testing for diagnosing the presence of CAD. Both tests may be used to assess prognosis after myocardial infarction, and dipyridamole imaging may be useful in patients undergoing preoperative evaluation. The use of the cold pressor test and isometric handgrip exercise have also been described. However, the value of both tests is limited by a relatively low sensitivity for detecting the presence of CAD. Other testing modalities--arm ergometry, intravenous infusion of beta-adrenergic agonists, and transthoracic pacing--show promise but require further assessment to confirm their value. JF - American heart journal AU - Stratmann, H G AU - Kennedy, H L AD - Department of Cardiology, St. Louis Veterans Administration Medical Center, MO 63125. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 1344 EP - 1365 VL - 117 IS - 6 SN - 0002-8703, 0002-8703 KW - Adrenergic beta-Agonists KW - 0 KW - Vasoconstrictor Agents KW - Dipyridamole KW - 64ALC7F90C KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test -- methods KW - Dipyridamole -- adverse effects KW - Heart -- diagnostic imaging KW - Humans KW - Echocardiography KW - Cardiac Pacing, Artificial -- methods KW - Cold Temperature KW - Radionuclide Imaging KW - Coronary Disease -- diagnosis KW - Coronary Disease -- therapy KW - Coronary Disease -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79007523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Evaluation+of+coronary+artery+disease+in+the+patient+unable+to+exercise%3A+alternatives+to+exercise+stress+testing.&rft.au=Stratmann%2C+H+G%3BKennedy%2C+H+L&rft.aulast=Stratmann&rft.aufirst=H&rft.date=1989-06-01&rft.volume=117&rft.issue=6&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-05 N1 - Date created - 1989-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases. AN - 78979007; 2498296 AB - Two patients who were concomitantly undergoing methadone maintenance treatment and receiving phenytoin suffered continuing opioid withdrawal symptoms as a results of phenytoin's acceleration of methadone metabolism. When anticonvulsant therapy was discontinued, these patients had seizures. One patient was switched to carbamazepine as an alternative anticonvulsant, but this treatment resulted in a similar clinical problem. When both patients received valproic acid instead, the withdrawal symptoms disappeared and their conditions stabilized. JF - The Journal of clinical psychiatry AU - Saxon, A J AU - Whittaker, S AU - Hawker, C S AD - Veterans Administration Medical Center, Seattle, WA 98108. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 228 EP - 229 VL - 50 IS - 6 SN - 0160-6689, 0160-6689 KW - Valproic Acid KW - 614OI1Z5WI KW - Phenytoin KW - 6158TKW0C5 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Seizures -- chemically induced KW - Drug Therapy, Combination KW - Substance Withdrawal Syndrome -- etiology KW - Humans KW - Adult KW - Heroin Dependence -- prevention & control KW - Middle Aged KW - Phenytoin -- adverse effects KW - Male KW - Valproic Acid -- pharmacology KW - Methadone -- therapeutic use KW - Methadone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78979007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Valproic+acid%2C+unlike+other+anticonvulsants%2C+has+no+effect+on+methadone+metabolism%3A+two+cases.&rft.au=Saxon%2C+A+J%3BWhittaker%2C+S%3BHawker%2C+C+S&rft.aulast=Saxon&rft.aufirst=A&rft.date=1989-06-01&rft.volume=50&rft.issue=6&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-07 N1 - Date created - 1989-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A phospholipase A2-activating protein (PLAP) stimulates human neutrophil aggregation and release of lysosomal enzymes, superoxide, and eicosanoids. AN - 78963465; 2541202 AB - We have recently isolated a human phospholipase A2-activating protein (PLAP) that shares antigenic and biochemical similarities with melittin, a well characterized bee venom phospholipase-stimulatory peptide. To explore the potential mechanisms of action of PLAP that extend beyond its effects on eicosanoid synthesis, we examined its effects on the release of human neutrophil lysosomal enzymes and superoxide, and on RBC hemolysis. These results were compared to the effects of melittin, which has been reported to induce enzyme release and hemolysis. We also examined the effects of PLAP on neutrophil aggregation and chemotaxis. PLAP induced neutrophils to release beta-glucuronidase and metalloproteinase enzyme activities as well as produce superoxide ion in both a dose- and time-dependent manner. Eicosanoid synthesis inhibitors did not abrogate these responses. PLAP induced release of arachidonic acid metabolites, but this response could be abrogated by eicosanoid synthesis inhibitors. PLAP also induced neutrophil aggregation and chemokinesis, but not chemotaxis. Concentrations of PLAP that induced these responses did not induce cellular toxicity as determined by light and electron microscopy, lactic dehydrogenase release, trypan blue dye exclusion, and RBC hemolysis. In contrast, prolonged incubation with higher concentrations of PLAP induced cell death that was similar to that observed with melittin. These findings suggest that the mechanisms of action of PLAP extend beyond the eicosanoid synthetic pathway, and that disordered regulation of PLAP may be responsible, at least in part, for chronic immune and inflammatory states. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Bomalaski, J S AU - Baker, D G AU - Brophy, L AU - Resurreccion, N V AU - Spilberg, I AU - Muniain, M AU - Clark, M A AD - Veterans Administration Medical Center, Medical College of Pennsylvania, Philadelphia 19104. Y1 - 1989/06/01/ PY - 1989 DA - 1989 Jun 01 SP - 3957 EP - 3962 VL - 142 IS - 11 SN - 0022-1767, 0022-1767 KW - Arachidonic Acids KW - 0 KW - Free Radicals KW - Proteins KW - phospholipase A2-activating protein KW - Superoxides KW - 11062-77-4 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Phospholipases KW - EC 3.1.- KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Trypan Blue KW - I2ZWO3LS3M KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - L-Lactate Dehydrogenase -- biosynthesis KW - Cell Aggregation -- drug effects KW - Enzyme Activation KW - Humans KW - Mice KW - Rabbits KW - Hemolysis -- drug effects KW - Cattle KW - Chemotaxis -- drug effects KW - Neutrophils -- metabolism KW - Superoxides -- metabolism KW - Phospholipases -- metabolism KW - Neutrophils -- enzymology KW - Neutrophils -- physiology KW - Lysosomes -- enzymology KW - Arachidonic Acids -- metabolism KW - Proteins -- physiology KW - Phospholipases A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78963465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=A+phospholipase+A2-activating+protein+%28PLAP%29+stimulates+human+neutrophil+aggregation+and+release+of+lysosomal+enzymes%2C+superoxide%2C+and+eicosanoids.&rft.au=Bomalaski%2C+J+S%3BBaker%2C+D+G%3BBrophy%2C+L%3BResurreccion%2C+N+V%3BSpilberg%2C+I%3BMuniain%2C+M%3BClark%2C+M+A&rft.aulast=Bomalaski&rft.aufirst=J&rft.date=1989-06-01&rft.volume=142&rft.issue=11&rft.spage=3957&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Serious systemic toxicity resulting from use of tetracaine for pharyngeal anesthesia in upper endoscopic procedures. AN - 78957846; 2721319 AB - Three cases of serious systemic toxicity from tetracaine pharyngeal anesthesia for upper endoscopic procedures are described. The pathophysiologic basis for systemic toxicity is discussed and a recommendation for preendoscopic anesthesia is provided. JF - Digestive diseases and sciences AU - Patel, D AU - Chopra, S AU - Berman, M D AD - Department of Medicine, Brockton/West Roxbury Veterans Administration Medical Center, Massachusetts 02401. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 882 EP - 884 VL - 34 IS - 6 SN - 0163-2116, 0163-2116 KW - Tetracaine KW - 0619F35CGV KW - Abridged Index Medicus KW - Index Medicus KW - Duodenoscopy KW - Gastroscopy KW - Humans KW - Aged KW - Middle Aged KW - Esophagoscopy KW - Male KW - Pharynx KW - Endoscopy -- adverse effects KW - Tetracaine -- adverse effects KW - Anesthesia, Local -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78957846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Serious+systemic+toxicity+resulting+from+use+of+tetracaine+for+pharyngeal+anesthesia+in+upper+endoscopic+procedures.&rft.au=Patel%2C+D%3BChopra%2C+S%3BBerman%2C+M+D&rft.aulast=Patel&rft.aufirst=D&rft.date=1989-06-01&rft.volume=34&rft.issue=6&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-12 N1 - Date created - 1989-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dual Diagnosis in Alcoholic Clients: Clinical Implications AN - 61590083; 198901701 AB - Social workers in substance-abuse programs frequently encounter alcoholic clients who display symptoms of other psychiatric disorders, which may be the result of prolonged alcohol abuse or may represent true coexisting disorders. Here, methods for distinguishing between symptoms & syndromes & for establishing primary & secondary diagnoses are presented & illustrated via case examples. Modified AA JF - Social Casework AU - Mulinski, Paul AD - Social Work Service Veterans Administration Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 333 EP - 339 VL - 70 IS - 6 KW - substance-abuse program clients, psychiatric disorder diagnosis methods, social workers KW - case examples KW - Client Relations KW - Diagnosis KW - Substance Abuse KW - Social Workers KW - Alcoholism KW - Program Evaluation KW - Mental Illness KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Casework&rft.atitle=Dual+Diagnosis+in+Alcoholic+Clients%3A+Clinical+Implications&rft.au=Mulinski%2C+Paul&rft.aulast=Mulinski&rft.aufirst=Paul&rft.date=1989-06-01&rft.volume=70&rft.issue=6&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Social+Casework&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Substance Abuse; Program Evaluation; Client Relations; Alcoholism; Diagnosis; Social Workers; Mental Illness ER - TY - JOUR T1 - The Elderly Mentally Retarded Person: Current Perspectives and Future Directions AN - 61438141; 198902264 AB - The aging retarded person presents unique difficulties to care providers because of inconsistencies in population definition, lack of coordination between resources for the aging & the retarded, & past neglect in the research literature. Here, the literature regarding the elderly retarded is reviewed relative to: (1) physical, behavioral, & emotional characteristics of the population; (2) service delivery & programming needs; & (3) suggestions for improved research methodology, with emphasis on a consumer-oriented knowledge base. Caveats regarding the application of programming mandates for mentally retarded individuals to an aging population are offered, along with suggestions for future research. 1 Table, 42 References. Modified HA JF - Journal of Applied Gerontology AU - Sison, Gustave F. P., Jr. AU - Cotten, Paul D AD - Psychology Service 116B3 Veterans Administration Center, Biloxi MS 39531 Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 151 EP - 167 VL - 8 IS - 2 SN - 0733-4648, 0733-4648 KW - elderly retarded, care provision issues KW - literature review KW - Aging KW - Delivery Systems KW - Mentally Retarded KW - Elderly KW - Mental Health Services KW - article KW - 6124: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61438141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Gerontology&rft.atitle=The+Elderly+Mentally+Retarded+Person%3A+Current+Perspectives+and+Future+Directions&rft.au=Sison%2C+Gustave+F.+P.%2C+Jr.%3BCotten%2C+Paul+D&rft.aulast=Sison&rft.aufirst=Gustave+F.&rft.date=1989-06-01&rft.volume=8&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Gerontology&rft.issn=07334648&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Aging; Elderly; Mentally Retarded; Delivery Systems; Mental Health Services ER - TY - JOUR T1 - Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. AN - 79039566; 2730662 AB - Since insulin effects on glucose transport persist in phorbol ester "desensitized" or "down-regulated" BC3H-1 myocytes, we reexamined the evidence for protein kinase C (PKC) depletion. After 24 hrs of 5 microM 12-0-tetradecanoyl phorbol-13-acetate (TPA) treatment, PKC-directed histone phosphorylation and acute TPA effects on glucose transport were lost, but PKC-dependent vinculin phosphorylation was still evident. Hydroxylapatite (HAP) chromatography revealed loss of a type III, but not a type II, PKC-dependent vinculin phosphorylation. Immunoblots of cytosolic preparations of PKC-"depleted" myocytes confirmed the retention of PKC. Our findings indicate that TPA "down-regulated" BC3H-1 myocytes contain immunoreactive and functionally active PKC. The latter may explain the continued effectiveness of both insulin and diacylglycerol (DiC8) for stimulating glucose transport in "down-regulated" cells. JF - Biochemical and biophysical research communications AU - Cooper, D R AU - Watson, J E AU - Acevedo-Duncan, M AU - Pollet, R J AU - Standaert, M L AU - Farese, R V AD - James A. Haley Veterans' Administration Hospital, Tampa, FL 33612. Y1 - 1989/05/30/ PY - 1989 DA - 1989 May 30 SP - 327 EP - 334 VL - 161 IS - 1 SN - 0006-291X, 0006-291X KW - Diglycerides KW - 0 KW - Histones KW - Isoenzymes KW - 1,2-dioctanoylglycerol KW - 1069-87-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Animals KW - Phosphorylation KW - Cells, Cultured KW - Histones -- metabolism KW - Muscles -- enzymology KW - Mice KW - Time Factors KW - Cell Line KW - Diglycerides -- metabolism KW - Protein Kinase C -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79039566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Retention+of+specific+protein+kinase+C+isozymes+following+chronic+phorbol+ester+treatment+in+BC3H-1+myocytes.&rft.au=Cooper%2C+D+R%3BWatson%2C+J+E%3BAcevedo-Duncan%2C+M%3BPollet%2C+R+J%3BStandaert%2C+M+L%3BFarese%2C+R+V&rft.aulast=Cooper&rft.aufirst=D&rft.date=1989-05-30&rft.volume=161&rft.issue=1&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-12 N1 - Date created - 1989-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Appreciation of Indirect Requests by Left- and Right-Brain-Damaged Patients: The Effects of Verbal Context and Conventionality of Wording AN - 85505841; 8904277 AB - Two studies examining the comprehension of indirect requests by patients with unilateral left- or right-hemisphere brain damage are reported. In the first study, an auditory comprehension task was administered to right-hemisphere-damaged (RHD) patients & age-matched controls (N = 14 each group). Stimuli consisted of 32 paragraph-length vignettes. Each concluded with an interrogative utterance that could be interpreted as a literal direct question or a nonliteral request. Half of the contexts encouraged interpretation as a direct question & half as an indirect request. Ss were asked to select from among four responses in each case: a correct response to the request, a correct response to the literal question, & two incorrect responses with the same syntactic form as the correct responses. Experiment 2 involved a text comprehension task in which a simpler version of the first task was administered to aphasic patients (N = 24) & RHD patients (N = 12). In this version, auditory stimuli were supplemented with written transcripts. Results confirm earlier findings that RHD patients can use contextual information for some interpretations, but are significantly impaired in this respect relative to controls. This supports previous claims of a right-hemisphere contribution to tasks involving integration of new & prior knowledge. Left-hemisphere-damaged (aphasic) patients were also impaired, but their pattern of performance differed from that of RHD patients. 3 Tables, 18 References. B. Annesser Murray JF - Brain and Language AU - Weylman, Sally T AU - Brownell, Hiram H AU - Roman, Mary AU - Gardner, Howard AD - c/o Brownell-Psychology Service 116B Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 580 EP - 591 VL - 36 IS - 4 SN - 0093-934X, 0093-934X KW - verbal context/wording conventionality effects, indirect requests appreciation, left- vs right-brain-damaged patients KW - Neurolinguistics (ne3a) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85505841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Appreciation+of+Indirect+Requests+by+Left-+and+Right-Brain-Damaged+Patients%3A+The+Effects+of+Verbal+Context+and+Conventionality+of+Wording&rft.au=Weylman%2C+Sally+T%3BBrownell%2C+Hiram+H%3BRoman%2C+Mary%3BGardner%2C+Howard&rft.aulast=Weylman&rft.aufirst=Sally&rft.date=1989-05-01&rft.volume=36&rft.issue=4&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Aphasia (ap1) ER - TY - JOUR T1 - Possible subtypes of affective disorder suggested by differences in cerebral laterality and testosterone. A preliminary report. AN - 85261283; pmid-2712661 AB - Two language-related dichotic listening tests of cerebral laterality were used to divide a group of 18 hospitalized patients with affective disorder into two subgroups of nine. The groups proved to differ in serum testosterone levels at the time of admission and in mean serum testosterone levels throughout hospitalization. Moreover, there was a positive correlation between testosterone level and symptom severity in one of the laterality-defined subgroups and a negative correlation in the other. These data (1) provide new evidence of pathophysiological heterogeneity within a single general diagnostic group; (2) suggest that noninvasive, inexpensive, and easily administered dichotic listening tests may be able to define pathophysiologically meaningful subgroups; and (3) suggest a role for testosterone-related alterations in left hemisphere function in the pathogeneses of some affective disorders. JF - Archives of General Psychiatry AU - Wexler, B E AU - Mason, J W AU - Giller, E L AD - Veterans Administration Medical Center, West Haven, CT 06516. PY - 1989 SP - 429 EP - 433 VL - 46 IS - 5 SN - 0003-990X, 0003-990X KW - Testosterone KW - Psychiatric Status Rating Scales KW - Support, U.S. Gov't, P.H.S. KW - Hospitalization KW - Human KW - Adult KW - Mood Disorders KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Psychotic Disorders KW - Depressive Disorder KW - Male KW - Hearing Tests KW - Dichotic Listening Tests KW - Laterality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85261283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Possible+subtypes+of+affective+disorder+suggested+by+differences+in+cerebral+laterality+and+testosterone.+A+preliminary+report.&rft.au=Wexler%2C+B+E%3BMason%2C+J+W%3BGiller%2C+E+L&rft.aulast=Wexler&rft.aufirst=B&rft.date=1989-05-01&rft.volume=46&rft.issue=5&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Archives+of+General+Psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Planning abilities in alcoholics, process and reactive schizophrenics, and normals. AN - 79231859; 2793291 AB - This study investigated planning abilities in alcoholics, process and reactive schizophrenics, and normals. Significant differences among the groups were found on all three planning tasks. Normals and alcoholics showed significantly greater planning ability on the picture arrangement task than the process schizophrenics. On the maze task, normals attained significantly higher scores than the process schizophrenics. On a task in which subjects predicted future effects from a present-day trend, alcoholics showed significantly greater planning ability than normals and process schizophrenics. Reactive schizophrenics did not differ significantly from any of the other groups on any task. The greater planning ability of the alcoholics in comparison with the normals on one of the tasks may be due to sampling and situational differences. The results suggest that deficits in planning abilities are temporary for alcoholics. JF - The International journal of the addictions AU - Murphy, T J AU - DeWolfe, A S AD - Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 435 EP - 444 VL - 24 IS - 5 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Schizophrenia -- rehabilitation KW - Neuropsychological Tests KW - Alcoholism -- rehabilitation KW - Concept Formation KW - Adaptation, Psychological KW - Schizophrenic Psychology KW - Alcoholism -- psychology KW - Problem Solving UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79231859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Planning+abilities+in+alcoholics%2C+process+and+reactive+schizophrenics%2C+and+normals.&rft.au=Murphy%2C+T+J%3BDeWolfe%2C+A+S&rft.aulast=Murphy&rft.aufirst=T&rft.date=1989-05-01&rft.volume=24&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-09 N1 - Date created - 1989-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics of intracellular calcium changes required for augmentation of phorbol ester-stimulated pancreatic enzyme secretion. AN - 79207869; 2476234 AB - Previous studies demonstrated that Ca2+ ionophores augment the pancreatic enzyme secretion caused by phorbol esters. The present study was performed to determine the nature of the cellular Ca2+ effects responsible for the augmentation. Relatively low concentrations (0.3-1.0 microM) of the nonfluorescent Ca2+ ionophore, 4-bromo-A23187 (Br-A23187), did not measurably increase free cytosolic Ca2+ ([Ca2+]i) and caused little or no enzyme release from guinea pig pancreatic acini. However, these concentrations of Br-A23187 augmented the amylase release caused by the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA). This augmentation occurred in the absence of extracellular Ca2+ as long as the intracellular agonist-sensitive pool contained Ca2+. Greater concentrations of Br-A23187 (3-10 microM) alone caused transient increases in [Ca2+]i and transient increases in amylase release. Although not resulting in an increase in [Ca2+]i, the low concentrations of Br-A23187 caused release of Ca2+ from the intracellular agonist-sensitive pool. These results suggest that Ca2+ mediates enzyme release by two distinct mechanisms in the pancreatic acinar cell. First, an increase in [Ca2+]i alone mediates enzyme release. Second, Ca2+ release from the agonist-sensitive pool not resulting in a measurable increase in [Ca2+]i augments enzyme release stimulated by a phorbol ester. The second effect of Ca2+ may be due to a small localized change in cell Ca2+ or an induction of cytosolic Ca2+ oscillations. JF - Cell calcium AU - Pandol, S J AU - Rodriguez, G AU - Muallem, S AU - Mendius, K E AD - Department of Medicine, Veterans Administration Medical Center, University of California, San Diego. PY - 1989 SP - 255 EP - 262 VL - 10 IS - 4 SN - 0143-4160, 0143-4160 KW - Ionophores KW - 0 KW - Calcimycin KW - 37H9VM9WZL KW - 4-bromo-A-23187 KW - 76455-48-6 KW - Amylases KW - EC 3.2.1.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Kinetics KW - Calcium -- metabolism KW - Ionophores -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pancreas -- enzymology KW - Calcimycin -- pharmacology KW - Calcimycin -- analogs & derivatives KW - Amylases -- secretion KW - Pancreas -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79207869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+calcium&rft.atitle=Characteristics+of+intracellular+calcium+changes+required+for+augmentation+of+phorbol+ester-stimulated+pancreatic+enzyme+secretion.&rft.au=Pandol%2C+S+J%3BRodriguez%2C+G%3BMuallem%2C+S%3BMendius%2C+K+E&rft.aulast=Pandol&rft.aufirst=S&rft.date=1989-05-01&rft.volume=10&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Cell+calcium&rft.issn=01434160&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-17 N1 - Date created - 1989-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Maternal alcohol ingestion inhibits fetal glucose uptake and growth. AN - 79129324; 2755417 AB - The distribution of maternally-derived glucose was determined in selected tissues of fetuses from ethanol-fed (EF) rats and from pair-fed (PF) and ad lib-fed (AF) controls. Maternal ethanol ingestion resulted in reduced fetal brain and liver weights and lower liver and lung glycogen levels compared to those of the PF or AF control groups. In addition, experimental fetuses exhibited reduced uptake of maternally-derived [3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma 3H activity and with the fetal:maternal plasma 3H ratio, an indicator of the rate of placental glucose transfer. Brain weight correlated with 2-DG content per gram tissue weight. These observations suggest that reduced nutrient availability due to impaired placental transfer plays a role in the intrauterine growth retardation associated with maternal ethanol ingestion. JF - Neurotoxicology and teratology AU - Singh, S P AU - Snyder, A K AU - Pullen, G L AD - Veterans Administration Medical Center, North Chicago, IL. PY - 1989 SP - 215 EP - 219 VL - 11 IS - 3 SN - 0892-0362, 0892-0362 KW - Blood Glucose KW - 0 KW - Ethanol KW - 3K9958V90M KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Animals KW - Liver -- anatomy & histology KW - Placenta -- anatomy & histology KW - Liver -- metabolism KW - Brain -- metabolism KW - Lung -- metabolism KW - Organ Size KW - Pregnancy KW - Rats, Inbred Strains KW - Rats KW - Lung -- anatomy & histology KW - Brain -- anatomy & histology KW - Placenta -- metabolism KW - Female KW - Maternal-Fetal Exchange KW - Ethanol -- adverse effects KW - Glucose -- metabolism KW - Embryonic and Fetal Development -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79129324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Maternal+alcohol+ingestion+inhibits+fetal+glucose+uptake+and+growth.&rft.au=Singh%2C+S+P%3BSnyder%2C+A+K%3BPullen%2C+G+L&rft.aulast=Singh&rft.aufirst=S&rft.date=1989-05-01&rft.volume=11&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-31 N1 - Date created - 1989-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro. AN - 79096975; 2546487 AB - Combinations of 3'-azido-3'-deoxythymidine and phosphonoformate produced a moderate synergistic inhibitory effect against human immunodeficiency virus type 1 in vitro at concentrations that are easily achieved in humans. The synergistic effect was more pronounced with increasing concentrations and was not secondary to toxic effects of the drugs. 3'-Azido-3'-deoxythymidine neither inhibited the replication of human cytomegalovirus in human embryonic lung fibroblasts nor interfered with the anticytomegalovirus effect of phosphonoformate. By using partially purified reverse transcriptase of human immunodeficiency virus type 1 and human cytomegalovirus DNA polymerase, various combinations of 3'-azido-3'-deoxythymidine-5'-triphosphate and phosphonoformate produced strong indications of additive interactions. The synergistic interactions in infected cells and the additive effects observed at the reverse transcriptase level indicate that mechanisms other than the reverse transcriptase may be of importance for the inhibition of human immunodeficiency virus replication by these two compounds. A concomitant treatment of cytomegalovirus infections, such as cytomegalovirus retinitis, with phosphonoformate in patients with acquired immunodeficiency syndrome receiving 3'-azido-3'-deoxythymidine may be appropriate, and this combination may also be useful in controlling human immunodeficiency virus infection. JF - Antimicrobial agents and chemotherapy AU - Eriksson, B F AU - Schinazi, R F AD - Veterans Administration Medical Center Atlanta, Decatur, Georgia 30033. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 663 EP - 669 VL - 33 IS - 5 SN - 0066-4804, 0066-4804 KW - Antiviral Agents KW - 0 KW - Organophosphorus Compounds KW - Foscarnet KW - 364P9RVW4X KW - Zidovudine KW - 4B9XT59T7S KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Phosphonoacetic Acid KW - N919E46723 KW - Index Medicus KW - AIDS/HIV KW - Viral Plaque Assay KW - Cells, Cultured KW - Humans KW - Monocytes -- drug effects KW - Drug Synergism KW - DNA-Directed DNA Polymerase -- metabolism KW - Virus Replication -- drug effects KW - Cytomegalovirus -- enzymology KW - Antiviral Agents -- pharmacology KW - Zidovudine -- pharmacology KW - Phosphonoacetic Acid -- analogs & derivatives KW - Phosphonoacetic Acid -- pharmacology KW - Organophosphorus Compounds -- pharmacology KW - HIV-1 -- drug effects KW - Cytomegalovirus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79096975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Combinations+of+3%27-azido-3%27-deoxythymidine+%28zidovudine%29+and+phosphonoformate+%28foscarnet%29+against+human+immunodeficiency+virus+type+1+and+cytomegalovirus+replication+in+vitro.&rft.au=Eriksson%2C+B+F%3BSchinazi%2C+R+F&rft.aulast=Eriksson&rft.aufirst=B&rft.date=1989-05-01&rft.volume=33&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1973 Jun;11(6):986-90 [4351463] Antimicrob Agents Chemother. 1988 Dec;32(12):1784-7 [2469387] Intervirology. 1980;14(1):7-15 [6259084] Eur J Biochem. 1981 Mar 16;115(1):207-16 [7227366] Biochim Biophys Acta. 1982 Feb 26;696(2):115-23 [6277381] Antiviral Res. 1982 May;2(1-2):81-95 [6179470] Pharmacol Ther. 1982;19(3):387-415 [6201932] Adv Enzyme Regul. 1984;22:27-55 [6382953] Ophthalmology. 1985 Apr;92(4):472-84 [2987769] Antimicrob Agents Chemother. 1985 Apr;27(4):445-8 [2988429] Lancet. 1985 Jun 29;1(8444):1480-2 [2409414] Scand J Infect Dis. 1985;17(2):157-63 [2992074] Biochem Pharmacol. 1985 Nov 15;34(22):4075-9 [2415134] Virology. 1985 Dec;147(2):326-35 [2416116] J Antimicrob Chemother. 1986 Mar;17(3):373-87 [3009383] Antimicrob Agents Chemother. 1986 May;29(5):867-72 [2425731] Antimicrob Agents Chemother. 1986 Jul;30(1):189-91 [3019235] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] Antimicrob Agents Chemother. 1986 Sep;30(3):491-8 [3777913] J Clin Microbiol. 1987 Jan;25(1):97-9 [2432084] N Engl J Med. 1987 Feb 26;316(9):557-64 [3543683] J Biol Chem. 1987 Feb 15;262(5):2187-9 [2434477] Nature. 1987 Feb 26-Mar 4;325(6107):773-8 [2434858] Antimicrob Agents Chemother. 1987 Feb;31(2):168-72 [3471180] N Engl J Med. 1987 Jul 23;317(4):185-91 [3299089] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] Antimicrob Agents Chemother. 1987 Apr;31(4):600-4 [2440379] Antiviral Res. 1987 Mar;7(3):139-49 [2440380] J Med Virol. 1987 Jun;22(2):157-62 [3039052] Am J Med. 1987 Aug;83(2):201-7 [3039841] Antimicrob Agents Chemother. 1987 Jun;31(6):839-43 [3304154] Antimicrob Agents Chemother. 1987 Jul;31(7):1046-50 [2444155] J Infect Dis. 1988 Mar;157(3):569-72 [2830347] Nature. 1988 Aug 4;334(6181):440-4 [3405290] Nature. 1988 Aug 4;334(6181):444-7 [2841608] J Infect Dis. 1988 Oct;158(4):862-5 [2844921] J Med Chem. 1978 Jan;21(1):109-12 [563460] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differences in organization of psychological needs between inpatient and outpatient opiate addicts. AN - 79070462; 2745736 AB - A total of 117 inpatients and 114 outpatient drug addicts were administered the Adjective Check List; protocols were subjected to a hierarchical cluster analysis. Results showed two basic clusters for inpatients and one large cluster in the outpatient sample, each different in personality need organization. At discharge, patients who moved from Clusters I or II (inpatient) to Cluster III (outpatient) continued with outpatient treatment. None of the "independent" patients pursued outpatient treatment, while patients in the "emotionally dependent" cluster who pursued outpatient treatment eventually were placed on methadone maintenance. Results suggest that drug addicts who request inpatient or outpatient treatment may be a self-selected sample who differ in personality organization, which, in turn, may predict treatment follow-up in an aftercare setting. JF - Journal of clinical psychology AU - Craig, R J AU - Olson, R AU - Shalton, G AD - West Side Veterans Administration Medical Center, Chicago, Illinois 60612. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 462 EP - 466 VL - 45 IS - 3 SN - 0021-9762, 0021-9762 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Personality Tests KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Opioid-Related Disorders -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Patient Dropouts -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79070462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Differences+in+organization+of+psychological+needs+between+inpatient+and+outpatient+opiate+addicts.&rft.au=Craig%2C+R+J%3BOlson%2C+R%3BShalton%2C+G&rft.aulast=Craig&rft.aufirst=R&rft.date=1989-05-01&rft.volume=45&rft.issue=3&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-17 N1 - Date created - 1989-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Presence of membrane binding sites for [D-TRP6]-luteinizing hormone-releasing hormone in experimental pancreatic cancer. AN - 79018136; 2567204 AB - Characteristics of binding sites (dissociation constant: Kd and maximal binding capacity: Bmax) for [D-Trp6]-luteinizing hormone-releasing hormone [( D-Trp6]-LH-RH]), somatostatin (SS-14) and epidermal growth factor (EGF) were evaluated in membrane fractions of N-Nitrosobis (2-oxopropyl) amine (BOP)-induced pancreatic adenocarcinoma of hamsters. Intact, normal hamster pancreata did not show any binding sites for [D-Trp6]-LH-RH, but specific [D-Trp6]-LH-RH binding sites with low affinity and high capacity were found after pancreatic cancer was induced with BOP. Membrane binding sites for SS-14 and EGF, with high affinity and low capacity were present, both in normal and cancerous pancreata. Normal hamster pancreatic tissue had significantly higher levels of SS-14 binding sites and lower concentration of EGF binding sites as compared to pancreatic carcinoma. In vivo treatment of hamsters bearing pancreatic cancers with microcapsules of agonist [D-Trp6]-LH-RH and the somatostatin analog RC-160 alone, or in combination, caused histopathological regression of tumors and concomitantly decreased the Kd and Bmax of [D-Trp6]-LH-RH, and increased the Bmax of the SS-14 binding sites. These findings represent the first demonstration of binding sites for [D-Trp6]-LH-RH in pancreatic cancers. Our results also suggest that tumor inhibitory effects of [D-Trp6]-LH-RH and RC-160 in pancreatic cancer could be mediated not only indirectly through suppression of sex-steroids, gastrointestinal hormones and growth factors, but also directly by an action on specific binding sites located on the tumor membranes. JF - Cancer letters AU - Fekete, M AU - Zalatnai, A AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 87 EP - 91 VL - 45 IS - 2 SN - 0304-3835, 0304-3835 KW - Antineoplastic Agents KW - 0 KW - Nitrosamines KW - Receptors, LHRH KW - Receptors, Neurotransmitter KW - Receptors, Somatostatin KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Receptor, Epidermal Growth Factor -- metabolism KW - Somatostatin -- therapeutic use KW - Receptors, Neurotransmitter -- metabolism KW - Mesocricetus KW - Somatostatin -- analogs & derivatives KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Female KW - Cricetinae KW - Gonadotropin-Releasing Hormone -- metabolism KW - Pancreatic Neoplasms -- metabolism KW - Antineoplastic Agents -- administration & dosage KW - Pancreatic Neoplasms -- chemically induced KW - Antineoplastic Agents -- metabolism KW - Pancreatic Neoplasms -- drug therapy KW - Gonadotropin-Releasing Hormone -- administration & dosage KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Receptors, LHRH -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79018136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Presence+of+membrane+binding+sites+for+%5BD-TRP6%5D-luteinizing+hormone-releasing+hormone+in+experimental+pancreatic+cancer.&rft.au=Fekete%2C+M%3BZalatnai%2C+A%3BSchally%2C+A+V&rft.aulast=Fekete&rft.aufirst=M&rft.date=1989-05-01&rft.volume=45&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-20 N1 - Date created - 1989-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The nonlinear contribution of nitrous oxide at sub-MAC concentrations to enflurane MAC in rats. AN - 78997732; 2719289 AB - The presumed linear relationship describing the contribution of nitrous oxide (N2O) to the enflurane requirement necessary to achieve a 1.0 MAC level of anesthesia was tested in rats (N = 84). Each rat received one of six different concentrations of N2O, and enflurane was adjusted to attain 1.0 MAC with the use of a standard tail clamp method. The resultant group MAC anesthetic concentrations were Group I-N2O = 0.0%, enflurane = 2.30%; Group II-N2O = 10.4%, enflurane = 2.19%; Group III-N2O = 30.7%, enflurane = 1.85%; Group IV-N2O = 61.8%, enflurane = 1.75%; Group V-N2O = 70.9%, enflurane = 1.56%; and Group VI-N2O = 80.3%, enflurane = 1.54%. Increasing the N2O concentration from 0-10%, from 30-60%, or 70-80% did not significantly decrease the enflurane requirement; however, increasing the N2O concentration from 10-30% or 60-70% produced a significant decrease (P less than 0.05) in the concentration of enflurane required for 1.0 MAC of anesthesia. Thus, in rats, increasing the concentration of N2O in sub-MAC ranges did not produce a linear decrease in the enflurane concentration required to add up to 1.0 MAC of anesthesia. These results are consistent with a dose-dependent interaction between N2O and the excitatory properties of enflurane; this interaction could represent synergism at low concentrations or antagonism at higher concentration of N2O. JF - Anesthesia and analgesia AU - Cole, D J AU - Kalichman, M W AU - Shapiro, H M AD - Department of Anesthesiology, Veterans Administration Medical Center, San Diego, California. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 556 EP - 562 VL - 68 IS - 5 SN - 0003-2999, 0003-2999 KW - Enflurane KW - 91I69L5AY5 KW - Nitrous Oxide KW - K50XQU1029 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Epilepsy -- chemically induced KW - Dose-Response Relationship, Drug KW - Drug Synergism KW - Male KW - Enflurane -- administration & dosage KW - Nitrous Oxide -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78997732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=The+nonlinear+contribution+of+nitrous+oxide+at+sub-MAC+concentrations+to+enflurane+MAC+in+rats.&rft.au=Cole%2C+D+J%3BKalichman%2C+M+W%3BShapiro%2C+H+M&rft.aulast=Cole&rft.aufirst=D&rft.date=1989-05-01&rft.volume=68&rft.issue=5&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-14 N1 - Date created - 1989-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Anesth Analg. 1990 Sep;71(3):305-7 [2393115] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A psychiatric patient classification system. An alternative to diagnosis-related groups. AN - 78993881; 2498585 AB - It is generally accepted that diagnosis-related groups (DRGs) for alcohol, drug, and mental disorders are inappropriate for inpatient prospective payment. To address this issue, the Veterans Administration (VA) supported a project to construct alternative classes that are more clinically meaningful, more homogeneous in their resource use, and that account for more variation in resource use among psychiatric and substance use cases than existing DRGs. This paper reports on this project. Using a data set containing universally available discharge data plus behavioral, social, and functional information obtained by a survey of 116,191 discharges from VA psychiatric beds, and with AUTOGRP as the classifying algorithm, a classification system was formed. Twelve psychiatric diagnostic groupings (PDGs) were identified, analogous to major diagnostic groups in the DRG system. Within each PDG, from 4 to 9 terminal groups of Psychiatric Patient Classes (PPCs) were formed and validated. The 12 substance abuse PPCs explain greater than 31% of the variation in length of stay; for the mental disorder PPCs the variance explanation is greater than 11%, a substantial improvement over DRGs that, for the same data set, explain less than 2 and 3%, respectively. With the addition of only 5 variables beyond those presently included in discharge data sets, greater precision for payment purposes can be achieved. Implications for adoption of this classification system are discussed. JF - Medical care AU - Ashcraft, M L AU - Fries, B E AU - Nerenz, D R AU - Falcon, S P AU - Srivastava, S V AU - Lee, C Z AU - Berki, S E AU - Errera, P AD - Veterans Administration Health Services Research & Development Program, Ann Arbor, Michigan. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 543 EP - 557 VL - 27 IS - 5 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Diagnosis-Related Groups KW - Length of Stay KW - Substance-Related Disorders -- classification KW - Humans KW - Algorithms KW - Mental Disorders -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78993881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=A+psychiatric+patient+classification+system.+An+alternative+to+diagnosis-related+groups.&rft.au=Ashcraft%2C+M+L%3BFries%2C+B+E%3BNerenz%2C+D+R%3BFalcon%2C+S+P%3BSrivastava%2C+S+V%3BLee%2C+C+Z%3BBerki%2C+S+E%3BErrera%2C+P&rft.aulast=Ashcraft&rft.aufirst=M&rft.date=1989-05-01&rft.volume=27&rft.issue=5&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-27 N1 - Date created - 1989-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dose-dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics. AN - 78986364; 2721103 AB - The influence of disulfiram on theophylline metabolism was studied in 20 recovering alcoholics. Ten of the patients, who were selected at random, received 250 mg of disulfiram daily. The other 10 patients received 500 mg of disulfiram daily. Two single-dose studies of theophylline kinetics were performed--one as a baseline control and the other after 1 week of treatment with disulfiram. With disulfiram pretreatment, the plasma clearance of theophylline was decreased from 105.7 +/- 10.2 (mean +/- SEM) to 83.1 +/- 8.1 ml/kg per hour (p less than 0.001) in the 250 mg group and from 94.3 +/- 13.3 to 65.4 +/- 10.7 ml/mg per hour (p less than 0.001) in the 500 mg group. The elimination half-life was prolonged significantly in both groups. The percent reduction in theophylline clearance was greater in the 500 mg group (32.5 +/- 3.1; range, 21.6 to 49.6) than it was in the 250 mg group (21.2 +/- 1.7; range, 14.6 to 29.6; p less than 0.01). Disulfiram decreased the formation of all theophylline metabolites in smokers in both treatment groups. In each group, the hydroxylation pathway was affected more than the demethylation pathway. These data indicate that at therapeutic doses disulfiram exerts a dose-dependent inhibitory effect on theophylline metabolism. Depending on the dose of disulfiram, a dose reduction of theophylline by as much as 50% may be necessary to minimize the risk of toxicity. JF - Clinical pharmacology and therapeutics AU - Loi, C M AU - Day, J D AU - Jue, S G AU - Bush, E D AU - Costello, P AU - Dewey, L V AU - Vestal, R E AD - Clinical Pharmacology and Gerontology Research Unit, Veterans Administration Medical Center, Boise, ID 83702. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 476 EP - 486 VL - 45 IS - 5 SN - 0009-9236, 0009-9236 KW - Theophylline KW - C137DTR5RG KW - Disulfiram KW - TR3MLJ1UAI KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Half-Life KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Middle Aged KW - Lung Diseases, Obstructive -- complications KW - Male KW - Disulfiram -- administration & dosage KW - Theophylline -- pharmacokinetics KW - Alcoholism -- metabolism KW - Disulfiram -- pharmacology KW - Theophylline -- therapeutic use KW - Alcoholism -- complications KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78986364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Dose-dependent+inhibition+of+theophylline+metabolism+by+disulfiram+in+recovering+alcoholics.&rft.au=Loi%2C+C+M%3BDay%2C+J+D%3BJue%2C+S+G%3BBush%2C+E+D%3BCostello%2C+P%3BDewey%2C+L+V%3BVestal%2C+R+E&rft.aulast=Loi&rft.aufirst=C&rft.date=1989-05-01&rft.volume=45&rft.issue=5&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-30 N1 - Date created - 1989-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Importance of diabetes in inhibition of pancreatic cancer by streptozotocin. AN - 78983360; 2523987 AB - Previous studies in our laboratory have demonstrated that the beta-cell toxin streptozotocin (STZ) inhibits the development of exocrine pancreatic cancer in the hamster when STZ is administered prior to treatment with the pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP). Because the administration of STZ leads to diabetes, we wished to determine whether the presence of diabetes was important in the inhibitory effect of STZ on pancreatic carcinogenesis or whether STZ acted through a mechanism unrelated to diabetes, perhaps by a direct toxic effect on tumor precursor cells. Whole pancreas transplantation was used to create a two-pancreas hamster model to test this hypothesis. The study demonstrated that (1) STZ inhibits the induction of pancreatic cancer in the hamster when given prior to BOP and (2) the inhibitory effect of STZ was demonstrable only when diabetes was present. The inhibitory effect of STZ appears to be systemic, related to diabetes, and not a direct effect on the pancreas. JF - The Journal of surgical research AU - Bell, R H AU - Sayers, H J AU - Pour, P M AU - Ray, M B AU - McCullough, P J AD - Department of Surgery, Veterans Administration Medical Center, Cincinnati, Ohio. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 515 EP - 519 VL - 46 IS - 5 SN - 0022-4804, 0022-4804 KW - Blood Glucose KW - 0 KW - Carcinogens KW - Nitrosamines KW - Streptozocin KW - 5W494URQ81 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Index Medicus KW - Pancreas Transplantation KW - Animals KW - Blood Glucose -- metabolism KW - Premedication KW - Mesocricetus KW - Cricetinae KW - Nitrosamines -- antagonists & inhibitors KW - Pancreatic Neoplasms -- blood KW - Pancreatic Neoplasms -- chemically induced KW - Diabetes Mellitus, Experimental -- etiology KW - Diabetes Mellitus, Experimental -- blood KW - Streptozocin -- pharmacology KW - Carcinogens -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78983360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Importance+of+diabetes+in+inhibition+of+pancreatic+cancer+by+streptozotocin.&rft.au=Bell%2C+R+H%3BSayers%2C+H+J%3BPour%2C+P+M%3BRay%2C+M+B%3BMcCullough%2C+P+J&rft.aulast=Bell&rft.aufirst=R&rft.date=1989-05-01&rft.volume=46&rft.issue=5&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-14 N1 - Date created - 1989-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Does determining serum alcohol concentrations in emergency department patients influence physicians' civil suit liability? AN - 78974726; 2719495 AB - Emergency physicians may incur liability when impaired patients who have been treated and released are subsequently involved in traffic crashes. We surveyed attorneys to assess their perception of how serum alcohol determinations might influence their liability in civil suits. Overall, 63.9% of the attorneys surveyed would advise patients that they received potentially negligent care if they were impaired following treatment in the emergency department and were involved in a traffic crashes. Perceived liability was altered by physician behavior as follows: 43.1% of attorneys would advise clients that they received potentially negligent care when impairment was documented by a test for serum alcohol concentration and no advice was given regarding drunk driving, and 17.3% of attorneys would give similar advice when impairment was not documented by a test for serum alcohol concentration and no advice was given regarding drunk driving. In contrast, only 3.5% of attorneys would suggest possible negligence when impairment was documented by a test for serum alcohol concentration and with advice subsequently given not to drive. The coupling of diagnosing impairment by the serum alcohol concentration and driving advice is medically sensible and might result in minimal civil liability. JF - Archives of internal medicine AU - Simel, D L AU - Feussner, J R AD - Ambulatory Care Service, Durham Veterans Administration Medical Center, NC 27705. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 1016 EP - 1018 VL - 149 IS - 5 SN - 0003-9926, 0003-9926 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - North Carolina KW - Adult KW - Accidents, Traffic -- legislation & jurisprudence KW - Counseling KW - Male KW - Malpractice -- legislation & jurisprudence KW - Ethanol -- blood KW - Alcoholic Intoxication -- diagnosis KW - Defensive Medicine -- legislation & jurisprudence KW - Patient Discharge -- legislation & jurisprudence KW - Emergency Service, Hospital -- legislation & jurisprudence KW - Social Responsibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78974726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Does+determining+serum+alcohol+concentrations+in+emergency+department+patients+influence+physicians%27+civil+suit+liability%3F&rft.au=Simel%2C+D+L%3BFeussner%2C+J+R&rft.aulast=Simel&rft.aufirst=D&rft.date=1989-05-01&rft.volume=149&rft.issue=5&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-15 N1 - Date created - 1989-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholecystokinin-induced desensitization of pepsinogen secretion from chief cells. AN - 78954948; 2497649 AB - When dispersed chief cells from guinea pig stomach were first incubated with cholecystokinin (CCK), washed, and then reincubated with CCK in fresh incubation solution, the stimulation of pepsinogen secretion and the rise in intracellular calcium concentration during the second incubation were reduced. CCK did not cause residual enzyme secretion but caused desensitization that was rapid, temperature dependent, dependent on extracellular calcium, reversible with time, and prevented but not reversed by CCK receptor antagonists. Cholecystokinin octapeptide (CCK-8) caused desensitization over the same range of concentrations that stimulate pepsinogen secretion, whereas the concentration of gastrin required to cause maximal desensitization was greater than that required to cause maximal stimulation of enzyme secretion. CCK-8 caused heterologous desensitization of pepsinogen secretion stimulated by agonists that interact with receptors to cause mobilization of cellular calcium and activation of protein kinase C or by agonists that bypass receptors to activate these mediators directly; however, CCK-8 did not induce desensitization of the stimulation caused by any secretagogue whose actions are mediated by adenosine 3',5'-cyclic monophosphate. Because CCK-8 caused greater desensitization of secretion stimulated by agonists that interact with receptors than by agonists that bypass receptors, it is likely that receptor modulation as well as a postreceptor action contribute to the ability of CCK to cause desensitization of pepsinogen secretion from chief cells. JF - The American journal of physiology AU - Cherner, J A AU - Naik, L AU - Singh, G AD - Gastroenterology Section, Veterans Administration Medical Center, Long Beach 90822. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - G837 EP - G845 VL - 256 IS - 5 Pt 1 SN - 0002-9513, 0002-9513 KW - Pepsinogens KW - 0 KW - Receptors, Cholecystokinin KW - Calcimycin KW - 37H9VM9WZL KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Temperature KW - Calcium -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Receptors, Cholecystokinin -- drug effects KW - Calcimycin -- pharmacology KW - Female KW - Pepsinogens -- secretion KW - Gastric Mucosa -- secretion KW - Sincalide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78954948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Cholecystokinin-induced+desensitization+of+pepsinogen+secretion+from+chief+cells.&rft.au=Cherner%2C+J+A%3BNaik%2C+L%3BSingh%2C+G&rft.aulast=Cherner&rft.aufirst=J&rft.date=1989-05-01&rft.volume=256&rft.issue=5+Pt+1&rft.spage=G837&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-16 N1 - Date created - 1989-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Life-threatening hyperkalemia in severe heart failure. AN - 78954035; 2711969 AB - The therapeutic course of patients with severe heart failure can be complicated by disturbances in potassium homeostasis. Although hypokalemia in more prevalent, hyperkalemia may occur. Among 730 consecutive patients admitted to the hospital because of heart failure, nine episodes of acute, life-threatening hyperkalemia (mean serum potassium level: 7.2 +/- 0.5 mEq/L) were diagnosed in six patients (0.8%) with severe chronic heart failure during maintenance oral potassium therapy and exacerbation of heart failure and/or after additional oral doses had been administered for correction of hypokalemia. Of nine hyperkalemic episodes observed, one was fatal, seven episodes were successfully treated, and one resolved spontaneously. Only one patient was receiving an angiotensin-converting enzyme inhibitor. An awareness of this complication and the clinical setting in which it is likely to occur could lead to earlier recognition and successful management. JF - American heart journal AU - Chakko, S C AU - Frutchey, J AU - Gheorghiade, M AD - Veterans Administration Medical Center, Salem, Va. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 1083 EP - 1091 VL - 117 IS - 5 SN - 0002-8703, 0002-8703 KW - Potassium Chloride KW - 660YQ98I10 KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Electrocardiography KW - Tachycardia -- physiopathology KW - Potassium Chloride -- adverse effects KW - Potassium Chloride -- therapeutic use KW - Potassium -- blood KW - Aged KW - Middle Aged KW - Chronic Disease KW - Tachycardia -- etiology KW - Water-Electrolyte Balance KW - Male KW - Hyperkalemia -- etiology KW - Hyperkalemia -- physiopathology KW - Hyperkalemia -- blood KW - Heart Failure -- drug therapy KW - Heart Failure -- complications KW - Heart Failure -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78954035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Life-threatening+hyperkalemia+in+severe+heart+failure.&rft.au=Chakko%2C+S+C%3BFrutchey%2C+J%3BGheorghiade%2C+M&rft.aulast=Chakko&rft.aufirst=S&rft.date=1989-05-01&rft.volume=117&rft.issue=5&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-05 N1 - Date created - 1989-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates. AN - 78945153; 2708529 AB - The role of oxygenation in the pathogenesis of alcoholic liver injury was investigated in six baboons fed alcohol chronically and in six pair-fed controls. All animals fed alcohol developed fatty liver with, in addition, fibrosis in three. No evidence for hypoxia was found, both in the basal state and after ethanol at moderate (30 mM) or high (55 mM) levels, as shown by unchanged or even increased hepatic venous partial pressure of O2 and O2 saturation of hemoglobin in the tissue. In controls, ethanol administration resulted in enhanced O2 consumption (offset by a commitant increase in splanchnic blood flow), whereas in alcohol fed animals, there was no increase. At the moderate ethanol dose, the flow-independent O2 extraction, measured by reflectance spectroscopy on the liver surface, tended to increase in control animals only, whereas a significant decrease was observed after the high ethanol dose in the alcohol-treated baboons. This was associated with a marked shift in the mitochondrial redox level in the alcohol-fed (but not in control) baboons, with striking rises in splanchnic output of glutamic dehydrogenase and acetaldehyde, reflecting mitochondrial injury. Increased acetaldehyde, in turn, may aggravate the mitochondrial damage and exacerbate defective O2 utilization. Thus impaired O2 consumption rather than lack of O2 supply characterizes liver injury produced by high ethanol levels in baboons fed alcohol chronically. JF - The Journal of clinical investigation AU - Lieber, C S AU - Baraona, E AU - Hernández-Muñoz, R AU - Kubota, S AU - Sato, N AU - Kawano, S AU - Matsumura, T AU - Inatomi, N AD - Bronx Veterans Administration Medical Center, Alcohol Research and Treatment Center, Bronx, NY 10468. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 1682 EP - 1690 VL - 83 IS - 5 SN - 0021-9738, 0021-9738 KW - Ethanol KW - 3K9958V90M KW - Acetaldehyde KW - GO1N1ZPR3B KW - Indocyanine Green KW - IX6J1063HV KW - Abridged Index Medicus KW - Index Medicus KW - Papio KW - Oxidation-Reduction KW - Animals KW - Viscera -- physiopathology KW - Liver -- enzymology KW - Viscera -- metabolism KW - Viscera -- blood supply KW - Acetaldehyde -- metabolism KW - Partial Pressure KW - Liver Diseases, Alcoholic -- metabolism KW - Ethanol -- blood KW - Oxygen Consumption -- drug effects KW - Liver Diseases, Alcoholic -- pathology KW - Liver Diseases, Alcoholic -- physiopathology KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78945153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Impaired+oxygen+utilization.+A+new+mechanism+for+the+hepatotoxicity+of+ethanol+in+sub-human+primates.&rft.au=Lieber%2C+C+S%3BBaraona%2C+E%3BHern%C3%A1ndez-Mu%C3%B1oz%2C+R%3BKubota%2C+S%3BSato%2C+N%3BKawano%2C+S%3BMatsumura%2C+T%3BInatomi%2C+N&rft.aulast=Lieber&rft.aufirst=C&rft.date=1989-05-01&rft.volume=83&rft.issue=5&rft.spage=1682&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-05 N1 - Date created - 1989-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem. 1972 Jun;18(6):523-7 [4337383] Am J Med. 1968 Feb;44(2):200-6 [5635674] N Engl J Med. 1975 Feb 20;292(8):386-9 [1110723] Proc Natl Acad Sci U S A. 1975 Mar;72(3):1137-41 [1055371] Fed Proc. 1976 Apr;35(5):1232-6 [944146] J Biol Chem. 1976 Aug 25;251(16):4908-13 [956168] Biochem Biophys Res Commun. 1977 Apr 25;75(4):1059-65 [861024] Proc Soc Exp Biol Med. 1977 Dec;156(3):509-13 [413113] Gastroenterology. 1979 Jan;76(1):105-15 [758131] Alcohol Clin Exp Res. 1980 Jan;4(1):40-3 [6766681] Am J Pathol. 1980 Mar;98(3):695-716 [6767406] Biochim Biophys Acta. 1981 Jan 14;634(1):1-10 [6258642] Biochem Pharmacol. 1981 Apr 1;30(7):799-802 [7195708] Clin Gastroenterol. 1981 May;10(2):355-73 [7018748] Hepatology. 1981 Jan-Feb;1(1):33-8 [6793493] Gastroenterology. 1982 May;82(5 Pt 1):925-31 [7037524] Alcohol Clin Exp Res. 1982 Summer;6(3):350-7 [6751130] J Pharmacol Exp Ther. 1983 Oct;227(1):78-83 [6352898] Pharmacol Biochem Behav. 1983;18 Suppl 1:443-7 [6685303] Hepatology. 1984 Mar-Apr;4(2):165-74 [6538546] Fundam Appl Toxicol. 1984 Apr;4(2 Pt 1):125-33 [6724187] Hepatology. 1984 Sep-Oct;4(5):912-7 [6479856] Gastroenterology. 1985 Apr;88(4):881-6 [3972232] Am J Physiol. 1985 May;248(5 Pt 1):G507-11 [4039538] Alcohol. 1985 Jan-Feb;2(1):163-7 [2990501] Alcohol. 1985 May-Jun;2(3):453-6 [4026964] Hepatology. 1986 Jan-Feb;6(1):87-91 [3943793] Am J Physiol. 1986 Apr;250(4 Pt 1):G518-23 [3963196] Alcohol Clin Exp Res. 1986 Jan-Feb;10(1):86-9 [3515997] Life Sci. 1987 Jan 19;40(3):253-8 [3796223] Hepatology. 1987 Jan-Feb;7(1):89-94 [3804210] Liver. 1987 Jun;7(3):176-81 [3613886] Eur J Clin Pharmacol. 1987;32(5):481-4 [3622596] N Engl J Med. 1987 Dec 3;317(23):1421-7 [3317042] Ann Intern Med. 1987 Dec;107(6):875-89 [2825572] Alcohol Clin Exp Res. 1987 Dec;11(6):559-61 [3324809] Gastroenterology. 1988 Apr;94(4):1047-52 [3345874] Life Sci. 1974 Oct 1;15(7):1327-34 [4549980] J Clin Invest. 1954 Oct;33(10):1338-45 [13201639] Clin Sci. 1961 Aug;21:43-57 [13689739] J Clin Invest. 1962 May;41:955-61 [14467395] J Clin Invest. 1965 Jun;44:1009-21 [14322019] Am J Clin Nutr. 1963 Aug;13:68-74 [14051216] J Clin Invest. 1960 May;39:776-81 [13808296] Am J Pathol. 1966 Apr;48(4):535-55 [5936783] Am J Pathol. 1966 Oct;49(4):593-603 [5924021] Fed Proc. 1967 Sep;26(5):1458-67 [6051328] J Med Primatol. 1974;3(3):153-63 [4214518] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tissue plasminogen activator-mediated thrombolysis of cerebral emboli and its effect on hemorrhagic infarction in rabbits. AN - 78924884; 2496332 AB - Tissue plasminogen activator (tPA) dissolves intravascular thrombus and restores blood flow after thromboembolic vascular occlusion. The utility of this agent for treatment of stroke in humans may be limited by post-reperfusion hemorrhagic complications. We studied tPA-mediated thrombolysis in an animal model of cerebrovascular occlusion in order to determine what factors, if any, predispose tPA-treated animals to suffer hemorrhage. Small blood clot emboli were injected into the internal carotid arteries of rabbits. Angiograms confirmed occlusion of the middle cerebral artery or internal carotid artery in 100% of subjects. tPA or saline was administered as a 30-minute infusion at various times after embolization. Hemorrhage rates were similar in all groups regardless of treatment. tPA increased the prothrombin time and the thrombin time but not the partial thromboplastin time. There was no correlation between these changes in blood coagulation and the finding of cerebral hemorrhage. We observed a significant association between stroke severity and cerebral hemorrhage. We conclude that tPA treatment successfully causes thrombolysis of cerebral emboli without causing an increase in the incidence of cerebral hemorrhage in rabbits. JF - Neurology AU - Lyden, P D AU - Zivin, J A AU - Clark, W A AU - Madden, K AU - Sasse, K C AU - Mazzarella, V A AU - Terry, R D AU - Press, G A AD - Department of Neurology, Veterans Administration Medical Center, San Diego, CA 92093. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 703 EP - 708 VL - 39 IS - 5 SN - 0028-3878, 0028-3878 KW - Fibrinolytic Agents KW - 0 KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cerebral Angiography KW - Blood Coagulation Tests KW - Rabbits KW - Fibrinolytic Agents -- therapeutic use KW - Tissue Plasminogen Activator -- therapeutic use KW - Intracranial Embolism and Thrombosis -- drug therapy KW - Cerebral Infarction -- pathology KW - Tissue Plasminogen Activator -- adverse effects KW - Fibrinolytic Agents -- adverse effects KW - Cerebral Hemorrhage -- pathology KW - Cerebral Infarction -- etiology KW - Cerebral Hemorrhage -- etiology KW - Intracranial Embolism and Thrombosis -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78924884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Tissue+plasminogen+activator-mediated+thrombolysis+of+cerebral+emboli+and+its+effect+on+hemorrhagic+infarction+in+rabbits.&rft.au=Lyden%2C+P+D%3BZivin%2C+J+A%3BClark%2C+W+A%3BMadden%2C+K%3BSasse%2C+K+C%3BMazzarella%2C+V+A%3BTerry%2C+R+D%3BPress%2C+G+A&rft.aulast=Lyden&rft.aufirst=P&rft.date=1989-05-01&rft.volume=39&rft.issue=5&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-07 N1 - Date created - 1989-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overview of Depression and Psychosis in Alzheimer's Disease AN - 60960537; 90V4870 AB - Thirty studies on Alzheimer's disease are reviewed to determine the prevalence & phenomenology of affective & psychotic symptoms in patients with this disorder. Results show that depressive & psychotic symptoms occurred in 30%-40% of the Alzheimer's disease patients. Isolated symptoms were 2-3 times as frequent as diagnosable affective or psychotic disorders. Paranoid delusions were the most common psychotic symptoms reported. Implications of the relationship of psychiatric symptoms to the clinical presentation of Alzheimer's disease, patterns of cognitive dysfunction, & clinical management are discussed, as well as areas for future research. 2 Tables, 45 References. HA JF - The American Journal of Psychiatry AU - Wragg, Robin E AU - Jeste, Dilip V AD - Dept Psychiatry 116A Veterans' Administration Medical Center, Highland Drive Pittsburgh PA 15206 Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 577 EP - 587 VL - 146 IS - 5 SN - 0002-953X, 0002-953X KW - affective/psychotic symptoms, Alzheimer's disease sufferers KW - literature review KW - Symptoms KW - Depression (Psychology) KW - Psychosis KW - Alzheimer's Disease KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60960537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Overview+of+Depression+and+Psychosis+in+Alzheimer%27s+Disease&rft.au=Wragg%2C+Robin+E%3BJeste%2C+Dilip+V&rft.aulast=Wragg&rft.aufirst=Robin&rft.date=1989-05-01&rft.volume=146&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Alzheimer's Disease; Depression (Psychology); Psychosis; Symptoms ER - TY - JOUR T1 - An Auditory Stroop Effect for Pitch, Loudness, and Time AN - 58190701; 8904262 AB - The Stroop effect involves interference between two inherent attributes of a stimulus. An auditory Stroop paradigm was used here to investigate hemispheric asymmetry in the processing of pitch. Monosyllabic words served as stimuli. Each of 18 words were recorded as congruent, noncongruent, or neutral with respect to one psychoacoustic dimension (pitch, loudness, duration). Six words were non-Stroop words & were recorded with normal pitch, loudness, & duration. Stroop & non-Stroop stimuli were presented monaurally to the right or left ear of normally hearing right-handed adults (N = 21). Ss were asked to make pitch, loudness, & duration judgments according to two response choices for each stimulus presentation. Results support the existence of an auditory Stroop effect for pitch. It is suggested that pitch & loudness interact in such a way that compatibility produces reduced processing time & incompatibility results in increased processing time to make a correct judgment. The interaction between psychoacoustic & semantic attributes of speech is discussed. 5 Tables, 2 Figures, 19 References. B. Annesser Murray JF - Brain and Language AU - Morgan, Alisa L R AU - Brandt, John F AD - Audiology/Speech Pathology 126 D7-111 Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 592 EP - 603 VL - 36 IS - 4 SN - 0093-934X, 0093-934X KW - hemispheric asymmetry, pitch processing KW - auditory Stroop paradigm utilized KW - normally hearing right-handed adults KW - Psychoacoustics (ps1) KW - article KW - 4017: psycholinguistics; psychoacoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58190701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=An+Auditory+Stroop+Effect+for+Pitch%2C+Loudness%2C+and+Time&rft.au=Morgan%2C+Alisa+L+R%3BBrandt%2C+John+F&rft.aulast=Morgan&rft.aufirst=Alisa+L&rft.date=1989-05-01&rft.volume=36&rft.issue=4&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Psychoacoustics (ps1) ER - TY - JOUR T1 - Comparison of desialylation of rat transferrin by cellular and non-cellular methods. AN - 78969751; 2719657 AB - We have previously shown that the liver endothelium can desialylate the glycoprotein transferrin (Tf). In the present work we provide evidence that asialotransferrin obtained by this means behaves differently on Ricinus communis agglutinin (RCA120) lectin affinity chromatography from asialotransferrin obtained by either neuraminidase treatment or acid hydrolysis. Purified rat transferrin was radiolabelled either with 125I (protein moiety) or with 3H (sialyl residues), and subsequently saturated with iron. It was then passed through an RCA120-agarose column to isolate the fully sialylated component. Sialylated Tf was then desialylated either by incubation with purified rat liver endothelium or, in vitro, by neuraminidase treatment or by acid hydrolysis. The protein was again subjected to RCA120 column chromatography. Although both neuraminidase treatment and acid hydrolysis almost completely desialylated the glycoprotein (as evidenced by near absence of 3H label), the glycoprotein was not retained by the RCA120-agarose column. By contrast, liver endothelium partially desialylated the glycoprotein, but this desialylated fraction was retained by the RCA120-agarose column. These results suggest that desialylation with neuraminidase or acid hydrolysis may be inadequate for functional studies of asialotransferrin. JF - The Biochemical journal AU - Irie, S AU - Minguell, J J AU - Tavassoli, M AD - University of Mississippi School of Medicine, Veterans Administration Medical Center, Jackson 39216. Y1 - 1989/04/15/ PY - 1989 DA - 1989 Apr 15 SP - 427 EP - 431 VL - 259 IS - 2 SN - 0264-6021, 0264-6021 KW - Asialoglycoproteins KW - 0 KW - Lectins KW - Plant Lectins KW - Ricinus communis agglutinin-1 KW - Sulfuric Acids KW - Transferrin KW - asialotransferrins KW - Neuraminidase KW - EC 3.2.1.18 KW - Index Medicus KW - Animals KW - Endothelium -- metabolism KW - Liver -- metabolism KW - Hydrolysis KW - Chromatography, Affinity KW - Plants, Toxic KW - Rats KW - Castor Bean KW - Chromatography, Agarose KW - Transferrin -- analogs & derivatives KW - Transferrin -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78969751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Comparison+of+desialylation+of+rat+transferrin+by+cellular+and+non-cellular+methods.&rft.au=Irie%2C+S%3BMinguell%2C+J+J%3BTavassoli%2C+M&rft.aulast=Irie&rft.aufirst=S&rft.date=1989-04-15&rft.volume=259&rft.issue=2&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-20 N1 - Date created - 1989-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1969 Mar;8(3):1133-41 [5781007] J Clin Invest. 1988 Aug;82(2):508-13 [3165384] J Biol Chem. 1971 Mar 25;246(6):1889-94 [4323238] Biochim Biophys Acta. 1972 May 9;266(2):543-7 [4338881] Biochem Biophys Res Commun. 1972 Jul 25;48(2):464-71 [5065068] Adv Enzymol Relat Areas Mol Biol. 1974;41(0):99-128 [4609051] Can J Biochem. 1974 Oct;52(10):845-53 [4154134] Methods Cell Biol. 1976;13:29-83 [177845] J Biol Chem. 1979 Oct 10;254(19):9795-9 [489569] J Biol Chem. 1979 Dec 10;254(23):12013-9 [500689] Biochem J. 1979 Sep 1;181(3):633-8 [518544] Biochem J. 1979 Nov 15;184(2):399-407 [534538] J Biol Chem. 1981 Apr 10;256(7):3245-52 [6259157] Alcohol Clin Exp Res. 1981 Fall;5(4):545-9 [7030111] Biochim Biophys Acta. 1982 Feb 8;685(1):6-12 [7059591] Scand J Haematol. 1982 Mar;28(3):205-14 [6283624] Proc Natl Acad Sci U S A. 1982 Oct;79(20):6186-90 [6292894] FEBS Lett. 1982 Dec 27;150(2):365-9 [7160481] J Biol Chem. 1983 Apr 25;258(8):4715-24 [6300098] J Histochem Cytochem. 1983 Feb;31(2):336-44 [6300220] J Biol Chem. 1983 Jul 25;258(14):8751-8 [6305999] J Biol Chem. 1983 Aug 10;258(15):9108-15 [6135697] J Biol Chem. 1983 Aug 25;258(16):9681-9 [6309781] J Cell Biol. 1983 Aug;97(2):329-39 [6309857] J Cell Biol. 1983 Aug;97(2):579-85 [6309864] Cell. 1983 Nov;35(1):321-30 [6313227] Biochemistry. 1983 Nov 22;22(24):5667-74 [6317024] Proc Natl Acad Sci U S A. 1984 Jan;81(1):175-9 [6141558] EMBO J. 1982;1(3):351-5 [6325161] Alcohol Clin Exp Res. 1984 May-Jun;8(3):287-92 [6377946] Cell. 1984 Jul;37(3):789-800 [6204769] J Biol Chem. 1984 Dec 10;259(23):14762-72 [6094573] Biochim Biophys Acta. 1985 Jul 30;846(1):14-20 [2990576] J Cell Physiol. 1985 Aug;124(2):283-7 [2995416] J Ultrastruct Res. 1985 Feb;90(2):194-202 [2999417] Biochem J. 1985 Dec 15;232(3):819-23 [4091824] J Biol Chem. 1986 Mar 15;261(8):3681-6 [3005297] Br J Haematol. 1986 Mar;62(3):487-94 [3954965] J Cell Biol. 1986 Apr;102(4):1298-303 [3958047] Anal Biochem. 1986 Mar;153(2):324-9 [3706714] Exp Cell Res. 1986 Aug;165(2):369-79 [3013662] Biochem Biophys Res Commun. 1986 Oct 15;140(1):94-100 [3778462] Am J Med Sci. 1987 Feb;293(2):103-11 [3551609] Am J Anat. 1987 Mar;178(3):241-9 [3578087] Lancet. 1987 Jun 6;1(8545):1292-4 [2884414] Trans Assoc Am Physicians. 1986;99:219-25 [3603925] J Biol Chem. 1988 Jun 25;263(18):8844-50 [3379048] Z Immunitatsforsch Allerg Klin Immunol. 1969 May;137(5):442-57 [4389062] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Covalent structure of collagen. Amino acid sequence of an arthritogenic cyanogen bromide peptide from type II collagen of bovine cartilage. AN - 78952601; 2714276 AB - Bovine articular type II collagen was prepared by limited pepsin digestion, differential salt fractionation and carboxymethylcellulose chromatography. Cyanogen bromide digestion of purified type II collagen alpha chains yielded twelve distinct peptides designated CB1-12. The peptide alpha 1(II)-CB11 was isolated by carboxymethylcellulose chromatography and Sephadex G-75S gel filtration. Automated Edman degradation together with chymotrypsin, thermolysin and trypsin digestion enabled identification of its complete amino acid sequence. Compared with type I and type III collagen, the data show similarity with alpha 1(I)-CB8 and alpha 1(III)-CB6-1-8-10-2 peptides, respectively. The peptide is located within residues 124-402 of the alpha 1(II) collagen chain and with its identification, now extends the known amino acid sequence of bovine type II cartilage collagen to 660 amino acid residues including alpha 1(II)-CB1-2-6-12-11-8-10 (partial). This corresponds to alpha 1(I)-CB0-1-2-4-5-8-3-7 (partial; 1-660) and alpha 1(III)-CB3A-3B-3C-7-6-1-8-10-2-4-5 (partial; 1-660) of bovine alpha 1(I) and alpha 1(III) collagen chains. JF - European journal of biochemistry AU - Seyer, J M AU - Hasty, K A AU - Kang, A H AD - Connective Tissue Research Laboratory, Veterans Administration Medical Center, Memphis, TN 38104. Y1 - 1989/04/15/ PY - 1989 DA - 1989 Apr 15 SP - 159 EP - 173 VL - 181 IS - 1 SN - 0014-2956, 0014-2956 KW - Peptide Fragments KW - 0 KW - Collagen KW - 9007-34-5 KW - Chymotrypsin KW - EC 3.4.21.1 KW - Trypsin KW - EC 3.4.21.4 KW - Thermolysin KW - EC 3.4.24.27 KW - Cyanogen Bromide KW - OS382OHJ8P KW - Index Medicus KW - Animals KW - Cattle KW - Arthritis, Experimental KW - Chromatography, Gel KW - Molecular Sequence Data KW - Cartilage, Articular KW - Chromatography, Ion Exchange KW - Amino Acid Sequence KW - Collagen -- toxicity KW - Peptide Fragments -- toxicity KW - Collagen -- isolation & purification KW - Peptide Fragments -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78952601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+biochemistry&rft.atitle=Covalent+structure+of+collagen.+Amino+acid+sequence+of+an+arthritogenic+cyanogen+bromide+peptide+from+type+II+collagen+of+bovine+cartilage.&rft.au=Seyer%2C+J+M%3BHasty%2C+K+A%3BKang%2C+A+H&rft.aulast=Seyer&rft.aufirst=J&rft.date=1989-04-15&rft.volume=181&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=European+journal+of+biochemistry&rft.issn=00142956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-22 N1 - Date created - 1989-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of a DNA probe from the deoxyribonucleotide sequence of a 3-N-aminoglycoside acetyltransferase [AAC(3)-I] resistance gene. AN - 85267844; pmid-2658795 AB - The aacC1 gene encoding the 3-N-aminoglycoside acetyltransferase [AAC(3)-I] was cloned from enteric plasmid pJR88, and its deoxyribonucleotide sequence was determined. Significant nucleotide homology was noted in the region extending from the proposed -35 sequences through the first 59 base pairs of the aacC1 gene open reading frame (ORF) and the upstream flanking regions and ORFs of several other antibiotic resistance genes. Sequences were noted to be homologous with the 6'-N-aminoglycoside acetyltransferase [AAC(6')-I], 2''-O-aminoglycoside adenylyltransferase [AAD(2'')], and 3''-O-aminoglycoside adenylyltransferase [AAD(3'')] resistance genes; the OXA-1, OXA-2, and PSE-2 beta-lactamase genes; and several dihydrofolate reductase genes. Small regions of homology were noted in the 3'-flanking regions of these resistance genes as well. A DNA probe for the aacC1 gene was selected from the nucleotide sequence information and was tested against a series of genetically and enzymatically defined strains. The probe, which proved specific for the aacC1 gene, was then tested against a series of 58 gentamicin-susceptible and 219 gentamicin-resistant gram-negative bacilli isolated from patients at the Seattle Veterans Administration Medical Center. Only six clinical isolates were noted to carry the aacC1 gene. Each was resistant to gentamicin but susceptible to kanamycin, tobramycin, and amikacin. The presence of homologous regions of DNA at both the 3' and 5' ends of the aacC1 gene reinforces the importance of choosing probes from within the ORFs of genes and of avoiding flanking sequences. When the homology with other sequences extends into the ORF, as it does with the aacC1 gene, development of a specific probe may require determination of the nucleotide sequence. JF - Antimicrobial Agents and Chemotherapy AU - Tenover, F C AU - Phillips, K L AU - Gilbert, T AU - Lockhart, P AU - O'Hara, P J AU - Plorde, J J AD - Seattle Veterans Administration Medical Center, Washington 98108. PY - 1989 SP - 551 EP - 559 VL - 33 IS - 4 SN - 0066-4804, 0066-4804 KW - DNA Probes KW - Base Sequence KW - DNA, Bacterial KW - Gentamicins KW - Molecular Sequence Data KW - Escherichia coli KW - Acetyltransferases KW - Drug Resistance, Microbial KW - Support, U.S. Gov't, Non-P.H.S. KW - Nucleic Acid Hybridization KW - Plasmids KW - Cloning, Molecular KW - Genes, Bacterial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85267844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Development+of+a+DNA+probe+from+the+deoxyribonucleotide+sequence+of+a+3-N-aminoglycoside+acetyltransferase+%5BAAC%283%29-I%5D+resistance+gene.&rft.au=Tenover%2C+F+C%3BPhillips%2C+K+L%3BGilbert%2C+T%3BLockhart%2C+P%3BO%27Hara%2C+P+J%3BPlorde%2C+J+J&rft.aulast=Tenover&rft.aufirst=F&rft.date=1989-04-01&rft.volume=33&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+and+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Hepatocellular carcinoma in Wilson's disease. Case report and review of the literature. AN - 85205204; pmid-2472436 AB - A 33-year-old man with Wilson's disease developed hemoptysis and radiographic evidence of nodular pulmonary infiltrates. A premortem diagnosis of hepatocellular carcinoma was made on the basis of alpha-naphthylannidase stains of pulmonary tissue obtained by open lung biopsy. We review all previous cases of Wilson's disease with this unusual complication and discuss the role of copper in hepatic oncogenesis as well as the alpha-naphthylannidase stain for the diagnosis of hepatocellular carcinoma. JF - Journal of Clinical Gastroenterology AU - Polio, J AU - Enriquez, R E AU - Chow, A AU - Wood, W M AU - Atterbury, C E AD - Department of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516. PY - 1989 SP - 220 EP - 224 VL - 11 IS - 2 SN - 0192-0790, 0192-0790 KW - Liver Neoplasms KW - Hepatolenticular Degeneration KW - Carcinoma, Hepatocellular KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Biopsy KW - Case Report KW - Staining and Labeling KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85205204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Hepatocellular+carcinoma+in+Wilson%27s+disease.+Case+report+and+review+of+the+literature.&rft.au=Polio%2C+J%3BEnriquez%2C+R+E%3BChow%2C+A%3BWood%2C+W+M%3BAtterbury%2C+C+E&rft.aulast=Polio&rft.aufirst=J&rft.date=1989-04-01&rft.volume=11&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Dyspepsia in NSAID users: the size of the problem. AN - 85204936; pmid-2738358 AB - Gastroduodenal intolerance is one of the major factors limiting the use of aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) in patients with rheumatic diseases. We previously demonstrated that dyspepsia was not a marker for ulcer in NSAID users. We have now evaluated dyspeptic symptoms in 245 arthritic patients (receiving 13 different NSAIDs) from the practices of two rheumatologists. Fifty-seven patients (23%) gave a history of previous peptic ulcers. Heartburn, indigestion, or sour stomach at least once within the past year was present in 62.5%; 36.7% had experienced these symptoms within the previous 2 months and 28.6% within the previous week. Only 39 patients (15.9%) had experienced dyspepsia more than once daily within the previous month, and 8 (3.3%) had dyspepsia greater than 5 times/day. Thirty-four of the 39 patients with daily dyspepsia claimed to obtain relief with cimetidine or antacids (34 patients) or food (2 patients), whereas 3 had not discovered anything that provided relief. Women smokers were more likely than nonsmokers to experience dyspepsia (p less than 0.001). Neither men smokers nor those with a history of previous ulcer were more likely to have dyspepsia than nonsmokers or those without a history of ulcer (p greater than 0.5). We were not able to find a statistical association between any NSAID, or combination of NSAIDs, and the frequency of dyspepsia. JF - Journal of Clinical Gastroenterology AU - Larkai, E N AU - Smith, J L AU - Lidsky, M D AU - Sessoms, S L AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas 77030. PY - 1989 SP - 158 EP - 162 VL - 11 IS - 2 SN - 0192-0790, 0192-0790 KW - Aged, 80 and over KW - Arthritis KW - Human KW - Adult KW - Aged KW - Middle Age KW - Anti-Inflammatory Agents, Non-Steroidal KW - Adolescent KW - Dyspepsia KW - Female KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85204936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Dyspepsia+in+NSAID+users%3A+the+size+of+the+problem.&rft.au=Larkai%2C+E+N%3BSmith%2C+J+L%3BLidsky%2C+M+D%3BSessoms%2C+S+L%3BGraham%2C+D+Y&rft.aulast=Larkai&rft.aufirst=E&rft.date=1989-04-01&rft.volume=11&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Auditory event-related potential probes and behavioral measures of aphasia. AN - 85142431; pmid-2468393 AB - This study examined the relationship between an auditory event-related potential probe technique measure of differential hemispheric processing and traditional tests of aphasia in aphasic patients. Subjects were 10 aphasic and 10 normal adult males. The results of the electrophysiological measures indicated that the aphasic subjects responded differently from the normal group particularly when the task required processing of verbal information. During the verbal task the aphasic group showed higher amplitude right hemisphere responses as compared to left. The normal group showed little hemispheric task related asymmetries. The pattern of electrical asymmetry in the aphasic group seems to be an indicator of severity as measured by traditional aphasia examinations. JF - Brain and Language AU - Selinger, M AU - Prescott, T E AU - Shucard, D W AD - Veterans Administration Medical Center, Denver, CO 80220. PY - 1989 SP - 377 EP - 390 VL - 36 IS - 3 SN - 0093-934X, 0093-934X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85142431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Auditory+event-related+potential+probes+and+behavioral+measures+of+aphasia.&rft.au=Selinger%2C+M%3BPrescott%2C+T+E%3BShucard%2C+D+W&rft.aulast=Selinger&rft.aufirst=M&rft.date=1989-04-01&rft.volume=36&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The influence of speaking rate on articulatory hypokinesia in parkinsonian dysarthria. AN - 85141904; pmid-2706450 AB - This study addressed the question of whether or not speaking rate influences articulatory hypokinesia in dysarthria associated with Parkinson's disease. Analyses of parkinsonian speech samples revealed mean speaking rates consistent with normal controls. Thus, speaking rate was not abnormal overall in this group of dysarthric subjects. Kinematic analyses of labial displacement amplitude, peak instantaneous velocity, and movement time were made during repetitive syllable production spoken at two speaking rates: 3-5 syllables/sec and 5-7 syllables/sec. The results suggested that labial movements were normal at the slower of the two speaking rates. Conversely, labial movements became hypokinetic as speaking rate increased to the rate consistent with conversational speech. These findings provide a physiologic basis for the perception of hypokinetic dysarthria in Parkinson's disease and suggest that speaking rate may be an important control variable contributing to articulatory hypokinesia in Parkinson's disease. Moreover, these findings provide quantitative evidence that articulatory hypokinesia plays a dominant role in the perception of parkinsonian dysarthria. JF - Brain and Language AU - Caligiuri, M P AD - Research Service, Veterans Administration Medical Center. PY - 1989 SP - 493 EP - 502 VL - 36 IS - 3 SN - 0093-934X, 0093-934X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85141904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+influence+of+speaking+rate+on+articulatory+hypokinesia+in+parkinsonian+dysarthria.&rft.au=Caligiuri%2C+M+P&rft.aulast=Caligiuri&rft.aufirst=M&rft.date=1989-04-01&rft.volume=36&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Individual behavioral and neuroendocrine differences in responsiveness to audiogenic stress. AN - 79255656; 2798540 AB - A relatively wide range of individual differences in neuroendocrine, immune and behavioral components of the audiogenic stress response has been found. In this study, an analysis of the association between the physiological and behavioral measures revealed that the degree of noise-induced suppression of both general activity and ingestive behaviors was significantly correlated with activation of adrenal steroid secretion following both acute and repeated noise exposures. Splenic natural killer cytotoxicity was not correlated with the behavioral measures of the stress response. Characterization of individual behavioral response profiles may be needed to evaluate accurately the neuroendocrine effects of stress. JF - Pharmacology, biochemistry, and behavior AU - Irwin, M R AU - Segal, D S AU - Hauger, R L AU - Smith, T L AD - Veterans Administration Medical Center, Clinical Research Center on Alcoholism, San Diego, CA 92161. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 913 EP - 917 VL - 32 IS - 4 SN - 0091-3057, 0091-3057 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Cytotoxicity, Immunologic KW - Animals KW - Spleen -- cytology KW - Killer Cells, Natural -- physiology KW - Noise -- adverse effects KW - Male KW - Stress, Physiological -- etiology KW - Feeding Behavior -- physiology KW - Corticosterone -- blood KW - Behavior, Animal -- physiology KW - Stress, Physiological -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79255656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Individual+behavioral+and+neuroendocrine+differences+in+responsiveness+to+audiogenic+stress.&rft.au=Irwin%2C+M+R%3BSegal%2C+D+S%3BHauger%2C+R+L%3BSmith%2C+T+L&rft.aulast=Irwin&rft.aufirst=M&rft.date=1989-04-01&rft.volume=32&rft.issue=4&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-07 N1 - Date created - 1989-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Program evaluation research in ongoing alcoholism treatment: a summary of the Tuscaloosa VA project. AN - 79234532; 2507456 AB - Early in 1980 a Veterans Administration Medical Center initiated a comprehensive program evaluation project of its Alcohol Treatment Unit. The project has resulted in numerous publications detailing the major findings; however, many outcomes of interest have not been reported, and no report is extant which summarizes the outcome of the program evaluation. In this paper, many results are reported for the first time, and previously published results are briefly described. Additionally, the problems encountered in program evaluation are discussed, as are the implications of the results of the project. JF - The International journal of the addictions AU - Alfano, A M AU - Thurstin, A H AD - Veterans Administration Medical Center, St. Cloud, Minnesota 56303. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 303 EP - 314 VL - 24 IS - 4 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Family Therapy KW - Cost-Benefit Analysis KW - Follow-Up Studies KW - Alcoholics Anonymous KW - Transactional Analysis KW - Alabama KW - Alcoholism -- therapy KW - Hospitals, Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79234532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Program+evaluation+research+in+ongoing+alcoholism+treatment%3A+a+summary+of+the+Tuscaloosa+VA+project.&rft.au=Alfano%2C+A+M%3BThurstin%2C+A+H&rft.aulast=Alfano&rft.aufirst=A&rft.date=1989-04-01&rft.volume=24&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-03 N1 - Date created - 1989-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Attrition within a detoxification unit: patient response to policy and psychological intervention. AN - 79231090; 2793283 AB - Professional psychological consultation with selected substance abusers was found in earlier work to stabilize patients as well as create organizational change. All patients subsequently were to undergo a psychological consultation. Three consecutive 10-month samples of male veterans (N = 254, 309, and 261) undergoing inpatient detoxification showed characteristic rectilinear decay curves while those refusing psychological consultation showed poisson-like negatively accelerating decay curves. Distributions clearly reflect (a) treatment contract, either 14- or 21-day length of stay; (b) presence or absence of a psychological consultation; and (c) an unknown factor. It is hypothesized that in addition to policy, the psychological focus upon self-experience rather than behavior had become internalized by the treatment team, thus creating a calmer interpersonal atmosphere, one more able to sustain the irritability, demandingness, and negativism of substance abusers, though with emotional cost to those involved. It is suggested that enlightened mental health policy be introduced on a wider scale. JF - The International journal of the addictions AU - Rogalski, C J AD - West Side Veterans Administration Hospital, Chicago, Illinois 60612. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 279 EP - 301 VL - 24 IS - 4 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Hospitalization KW - Length of Stay KW - Humans KW - Adult KW - Referral and Consultation KW - Middle Aged KW - Chicago KW - Male KW - Hospitals, Veterans KW - Substance-Related Disorders -- therapy KW - Psychotherapy KW - Patient Compliance KW - Health Policy KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79231090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Attrition+within+a+detoxification+unit%3A+patient+response+to+policy+and+psychological+intervention.&rft.au=Rogalski%2C+C+J&rft.aulast=Rogalski&rft.aufirst=C&rft.date=1989-04-01&rft.volume=24&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-03 N1 - Date created - 1989-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurocognitive impairment: the unrecognized component of dual diagnosis in substance abuse treatment. AN - 79139930; 2760756 AB - Brief neuropsychological tests were administered to an inpatient substance abuse population to (1) evaluate the status of neurocognitive functioning at admission, (2) assess changes that may occur during the treatment program, and (3) compare various testing devices for clinical application in this setting. Patients entering a 14-day inpatient substance abuse unit were tested within a few days of admission with the Neurobehavioral Cognitive Status Examination (NCSE), the screening test for the Luria-Nebraska Neuropsychological Battery, and the Trail Making Test. Impaired neurocognitive performance was observed in approximately two-thirds of patients; the most frequently compromised areas of functioning involved attention and memory, calculation, abstraction, ability to follow complex commands, and visuospatial skills. Readministration of the NCSE prior to discharge detected a statistically significant improvement in attentional abilities, and a tendency toward improvement for verbal comprehension and abstraction. Discussion of these findings addresses several issues: (1) the frequency and degree of impairment in this population; (2) the observed variability of cognitive functioning; (3) the question of clinical improvement in neurocognitive functioning observed during a program of this length; and (4) a preference for the NCSE in this setting. The authors argue for the routine neuropsychological assessment of substance abusers, and discuss the above issues in terms of their implications for treatment at both the individual and programmatic level. Discussion of two cases illustrates the application of the NCSE, and the effect of finding organic impairment on staff attitudes and treatment issues. JF - Journal of psychoactive drugs AU - Meek, P S AU - Clark, H W AU - Solana, V L AD - Substance Abuse Inpatient Unit, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1989 SP - 153 EP - 160 VL - 21 IS - 2 SN - 0279-1072, 0279-1072 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Lung Neoplasms -- complications KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- therapy KW - Adult KW - Psychomotor Performance KW - Middle Aged KW - Alcoholism -- psychology KW - Male KW - Female KW - Psychological Tests KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Cognition Disorders -- diagnosis KW - Substance-Related Disorders -- psychology KW - Cognition Disorders -- psychology KW - Cognition Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79139930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Neurocognitive+impairment%3A+the+unrecognized+component+of+dual+diagnosis+in+substance+abuse+treatment.&rft.au=Meek%2C+P+S%3BClark%2C+H+W%3BSolana%2C+V+L&rft.aulast=Meek&rft.aufirst=P&rft.date=1989-04-01&rft.volume=21&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-20 N1 - Date created - 1989-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine. AN - 79118450; 2501941 AB - 1. The hepatic microsomal 9-hydroxylation of N-2-fluorenylacetamide (2-FAA) is greater in the presence of male, or absence of female, hormones. Thus, 9-hydroxy-2-FAA was the major microsomal metabolite of male rats, which formed 6-fold greater amounts than did female rats. One week after gonadectomy, the amount of 9-hydroxy-2-FAA formed by male rats was decreased by 61%, whereas that formed by female rats was increased 1.4-fold. 2. Treatment of rats with phenobarbital (PB) increased 2- to 3-fold the capacities of hepatic microsomes of both sexes (normal and gonadectomized) for 9-hydroxylation of 2-FAA. 3. Hepatic microsomes of male rats also had greater capacities to form 9-oxo-2-FAA, the metabolite of 9-hydroxy-2-FAA, and 6-hydroxy-2-FAA, a newly identified microsomal metabolite of 2-FAA. These metabolites were also decreased by orchidectomy and induced by PB. 4. 9-Hydroxy-2-FAA was a poor substrate for hepatic microsomal UDP-glucuronyltransferase, and conjugation was not induced by treatment of rats with PB. This indicated retention of 9-hydroxy-2-FAA in the liver and/or further metabolism (e.g. to 9-oxo-2-FAA). 5. The formation of 9-oxo-2-FAA from 2-FAA or 9-hydroxy-2-FAA was increased (1.5-fold) two weeks after treatment of male rats with a single i.p. dose of diethylnitrosamine (200 mg/kg), an initiator of hepatocarcinogenesis. 6. Based on the data we suggest that 9-oxidized metabolites of 2-FAA, the preferential formation of which coincides with the susceptibility of the rat to hepatocarcinogenesis, are promoters. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Malejka-Giganti, D AU - Magat, W J AU - Decker, R W AD - Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 431 EP - 444 VL - 19 IS - 4 SN - 0049-8254, 0049-8254 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - NADP KW - 53-59-8 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - NADH Dehydrogenase KW - EC 1.6.99.3 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glucuronidase KW - EC 3.2.1.31 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - NADH Dehydrogenase -- metabolism KW - Glucuronidase -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Glucuronosyltransferase -- metabolism KW - NADP -- metabolism KW - Castration KW - Chromatography, High Pressure Liquid KW - Hydroxylation KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Female KW - Male KW - Phenobarbital -- pharmacology KW - 2-Acetylaminofluorene -- metabolism KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Diethylnitrosamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79118450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=Modifications+of+hepatic+microsomal+9-oxidation+of+N-2-fluorenylacetamide+in+response+to+gonadectomy+and+treatment+of+rats+with+phenobarbital+or+diethylnitrosamine.&rft.au=Malejka-Giganti%2C+D%3BMagat%2C+W+J%3BDecker%2C+R+W&rft.aulast=Malejka-Giganti&rft.aufirst=D&rft.date=1989-04-01&rft.volume=19&rft.issue=4&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=00498254&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-15 N1 - Date created - 1989-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuroreceptor changes in the putamen of alcohol abusers. AN - 79031074; 2543230 AB - The purpose of this study was to determine if alcohol abuse affects muscarinic cholinergic and benzodiazepine receptors in histologically normal brains obtained at autopsy in a general hospital population. Patients were excluded from this study if they had clinical brain (including Wernicke's) disease, died in coma, had liver disease, significant brain atrophy, or dementia severe enough to require institutionalization. We found that muscarinic cholinergic synaptic receptor density determined with [3H]quinuclidinyl benzilate was decreased by 40% in homogenates of the putamen of 27 alcohol abusers compared with 37 matched nonalcoholic controls. In contrast, receptor densities and affinities of benzodiazepine receptors determined with [3H]flunitrazepam were not significantly different in the two groups. Age and death-autopsy time interval had no significant effects on either wet tissue protein concentrations, yields of protein after centrifugation, or receptor binding. The contributions of age and time interval were each less than 3% of the total variance of protein concentrations and receptor binding. When patients who had received cholinergic, anticholinergic, or benzodiazepine medications before death were excluded or included we observed no significant effects on the final results. Pneumonia, known to be associated with acute hypoxia, and chronic obstructive pulmonary disease, known to be associated with chronic hypoxia, were approximately equally distributed between the two groups and had no significant effects on the results reported here. It is significant that the loss of muscarinic and the sparing of benzodiazepine receptors in the putamen occurs in histologically normal brains in the absence of significant atrophy and gross dementia. It implies that these changes are early in the development of alcoholic encephalopathy.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Freund, G AU - Ballinger, W E AD - Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 213 EP - 218 VL - 13 IS - 2 SN - 0145-6008, 0145-6008 KW - Receptors, GABA-A KW - 0 KW - Receptors, Neurotransmitter KW - Flunitrazepam KW - 620X0222FQ KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Index Medicus KW - Aging -- metabolism KW - Humans KW - Hypoxia -- metabolism KW - Adult KW - Receptors, GABA-A -- metabolism KW - Binding, Competitive -- drug effects KW - Receptors, GABA-A -- drug effects KW - Flunitrazepam -- metabolism KW - Putamen -- metabolism KW - Receptors, Neurotransmitter -- drug effects KW - Alcoholism -- metabolism KW - Putamen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79031074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Neuroreceptor+changes+in+the+putamen+of+alcohol+abusers.&rft.au=Freund%2C+G%3BBallinger%2C+W+E&rft.aulast=Freund&rft.aufirst=G&rft.date=1989-04-01&rft.volume=13&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-27 N1 - Date created - 1989-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alpha-theta brainwave training and beta-endorphin levels in alcoholics. AN - 79030041; 2524976 AB - An alpha-theta brainwave biofeedfack training program was applied as a novel treatment technique for chronic alcoholics. Following a temperature biofeedback pretraining phase, experimental subjects completed 15 30-min sessions of alpha-theta biofeedback training. Compared to a nonalcoholic control group and a traditionally treated alcoholic control group, alcoholics receiving brainwave training (BWT) showed significant increases in percentages of EEG record in alpha and theta rhythms, and increased alpha rhythm amplitudes. Alcoholics receiving BWT showed a gradual increase in alpha and theta brain rhythms across the 15 experimental sessions. These experimentally treated alcoholics showed sharp reductions in self-assessed depression (Beck's Depression Inventory) compared to the control groups. Alcoholics receiving standard medical treatment (abstinence, group psychotherapy, antidepressants) showed a significant elevation in serum beta-endorphin levels at the conclusion of the experiment. This neuropeptide is an index of stress and a stimulant of caloric (e.g., ethanol) intake. Application of brainwave treatment, a relaxation therapy, appears to counteract the increase in circulating beta-endorphin levels seen in the control group of alcoholics. 13-month follow-up data indicate sustained prevention of relapse in alcoholics that completed alpha-theta brainwave training. JF - Alcoholism, clinical and experimental research AU - Peniston, E G AU - Kulkosky, P J AD - Veterans Administration Medical Center, Fort Lyon, Colorado 81038. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 271 EP - 279 VL - 13 IS - 2 SN - 0145-6008, 0145-6008 KW - beta-Endorphin KW - 60617-12-1 KW - Index Medicus KW - Socioeconomic Factors KW - Biofeedback, Psychology KW - Psychiatric Status Rating Scales KW - Depressive Disorder -- psychology KW - Humans KW - Electroencephalography KW - Follow-Up Studies KW - Alcoholism -- therapy KW - beta-Endorphin -- blood KW - Alpha Rhythm KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79030041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alpha-theta+brainwave+training+and+beta-endorphin+levels+in+alcoholics.&rft.au=Peniston%2C+E+G%3BKulkosky%2C+P+J&rft.aulast=Peniston&rft.aufirst=E&rft.date=1989-04-01&rft.volume=13&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-27 N1 - Date created - 1989-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis. AN - 78958128; 2712618 AB - A patient with rheumatoid arthritis developed hepatic veno-occlusive disease following the use of azathioprine. Although azathioprine induced veno-occlusive disease is suspected to occur more frequently in patients with autoimmune dysfunction, it has not previously been reported as a complication of treatment in rheumatoid arthritis. The mechanism responsible for this condition remains unknown. JF - Annals of the rheumatic diseases AU - Lemley, D E AU - DeLacy, L M AU - Seeff, L B AU - Ishak, K G AU - Nashel, D J AD - Department of Medicine, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 342 EP - 346 VL - 48 IS - 4 SN - 0003-4967, 0003-4967 KW - Azathioprine KW - MRK240IY2L KW - Index Medicus KW - Liver -- pathology KW - Humans KW - Middle Aged KW - Male KW - Arthritis, Rheumatoid -- drug therapy KW - Hepatic Veno-Occlusive Disease -- chemically induced KW - Azathioprine -- adverse effects KW - Hepatic Veno-Occlusive Disease -- pathology KW - Arthritis, Rheumatoid -- pathology KW - Arthritis, Rheumatoid -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78958128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+rheumatic+diseases&rft.atitle=Azathioprine+induced+hepatic+veno-occlusive+disease+in+rheumatoid+arthritis.&rft.au=Lemley%2C+D+E%3BDeLacy%2C+L+M%3BSeeff%2C+L+B%3BIshak%2C+K+G%3BNashel%2C+D+J&rft.aulast=Lemley&rft.aufirst=D&rft.date=1989-04-01&rft.volume=48&rft.issue=4&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+rheumatic+diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-07 N1 - Date created - 1989-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Medicine (Baltimore). 1980 Sep;59(5):367-79 [7432153] Ann Rheum Dis. 1954 Dec;13(4):277-90 [13229234] Am J Med. 1980 Feb;68(2):285-90 [6986767] Ann Intern Med. 1977 Dec;87(6):717-9 [412451] J Clin Pathol. 1974 Dec;27(12):963-6 [4452745] Arthritis Rheum. 1975 Jan-Feb;18(1):15-20 [1090297] Gastroenterology. 1973 Apr;64(4):622-9 [4633722] Lancet. 1970 Apr 25;1(7652):861-3 [4191507] Ann Rheum Dis. 1980 Apr;39(2):152-4 [7387219] Arch Intern Med. 1981 Feb 23;141(3 Spec No):333-42 [7469624] Hum Pathol. 1981 Jan;12(1):60-71 [7203455] Am J Med. 1982 Jul;73(1):35-40 [7091172] Arch Intern Med. 1983 Mar;143(3):495-502 [6338851] Gastroenterology. 1984 Jan;86(1):162-5 [6689657] Arthritis Rheum. 1984 Jan;27(1):104-8 [6691850] Arthritis Rheum. 1984 Jul;27(7):721-7 [6378208] Gastroenterology. 1986 Feb;90(2):446-54 [3510146] Ann Intern Med. 1986 May;104(5):651-5 [3008617] J R Soc Med. 1986 Mar;79(3):171-3 [3701755] Am J Med. 1986 Aug;81(2):297-306 [3526887] J Rheumatol. 1986 Dec;13(6):1117-8 [3560101] Comment In: Ann Rheum Dis. 1989 Sep;48(9):791 [2802807] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of cis-platinum-induced Sertoli cell dysfunction in rodents. AN - 78947091; 2711396 AB - The present study examined the effects of dosage and frequency of cis-platinum administration on various aspects of Sertoli cell function and its correlation with the status of spermatogenesis in rats 1 and 9 weeks after the initial drug administration. Adult male Sprague-Dawley rats were administered cis-platinum (10 mg/kg) intraperitoneally as a single dose or as five daily doses of 2 mg/kg. Electron microscopic observation of testicular tissues fixed in the presence of lanthanum revealed that cis-platinum administration resulted in leakage of the Sertoli cell tight junctions. This occurred as early as 24 hr after the five daily injections, and persisted at least 40 days. Testicular androgen-binding protein (ABP) content was not significantly affected by either treatment regimen after 1 or 9 weeks of recovery. On the other hand, serum ABP values were significantly elevated after 9 weeks of recovery. In addition, the increased sodium and decreased potassium concentrations in seminiferous tubular fluid noted in cis-platinum-treated animals were also indicative of abnormal Sertoli cell secretory function. Degeneration of spermatogenic cells was noted as early as 5 days after the last drug administration; and partial restoration of spermatogenesis was noted after 40 days of recovery. We conclude that in rats both morphological and biochemical properties of Sertoli cells are affected by cis-platinum administration. These changes in Sertoli cell function may be responsible for the cis-platinum-induced impairment of spermatogenesis in these animals. JF - Toxicology and applied pharmacology AU - Pogach, L M AU - Lee, Y AU - Gould, S AU - Giglio, W AU - Meyenhofer, M AU - Huang, H F AD - Department of Medicine, East Orange Veterans Administration Medical Center, New Jersey 07019. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 350 EP - 361 VL - 98 IS - 2 SN - 0041-008X, 0041-008X KW - Androgen-Binding Protein KW - 0 KW - Electrolytes KW - Testosterone KW - 3XMK78S47O KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Androgen-Binding Protein -- analysis KW - Animals KW - Testosterone -- analysis KW - Spermatogenesis -- drug effects KW - Intercellular Junctions -- drug effects KW - Electrolytes -- analysis KW - Male KW - Organ Size -- drug effects KW - Sertoli Cells -- ultrastructure KW - Sertoli Cells -- drug effects KW - Cisplatin -- toxicity KW - Sertoli Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78947091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Characterization+of+cis-platinum-induced+Sertoli+cell+dysfunction+in+rodents.&rft.au=Pogach%2C+L+M%3BLee%2C+Y%3BGould%2C+S%3BGiglio%2C+W%3BMeyenhofer%2C+M%3BHuang%2C+H+F&rft.aulast=Pogach&rft.aufirst=L&rft.date=1989-04-01&rft.volume=98&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Spatial learning of visual 'nonsense figures' during experimental ethanol intoxication. AN - 78945444; 2717366 AB - The interaction of alcohol and visuospatial learning was evaluated during two experimental sessions. During one session, participants were experimentally intoxicated to obtain a blood alcohol concentration of at least 0.10%. During another session, a nonalcohol placebo was administered. The learning task consisted of a paired-associate paradigm requiring participants to learn the distinct spatial positions of 6 visually presented "nonsense shapes." The visuospatial learning of participants in the placebo condition was generally superior to their learning while intoxicated. However, intercorrelations of performance measures indicated that the relation between alcohol ingestion and performance differences across conditions was not linear. JF - Perceptual and motor skills AU - Cohen, M J AU - Schandler, S L AU - McArthur, D L AD - Veterans Administration Medical Center, Long Beach, CA 90822. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 599 EP - 606 VL - 68 IS - 2 SN - 0031-5125, 0031-5125 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Alcoholic Intoxication -- psychology KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Space Perception -- drug effects KW - Ethanol -- pharmacology KW - Learning -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78945444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Spatial+learning+of+visual+%27nonsense+figures%27+during+experimental+ethanol+intoxication.&rft.au=Cohen%2C+M+J%3BSchandler%2C+S+L%3BMcArthur%2C+D+L&rft.aulast=Cohen&rft.aufirst=M&rft.date=1989-04-01&rft.volume=68&rft.issue=2&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overwork weakness in rats with acrylamide neuropathy. AN - 78943483; 2539170 AB - Exercised rats have larger myelinated nerve fibers than sedentary rats and exercised rats with acrylamide neuropathy have smaller fibers than acrylamide-treated sedentary rats. These nerve fiber changes were the result of work hypertrophy and overwork atrophy, respectively. This study was designed to reassess morphologic changes in nerves after overwork was induced in rats with acrylamide neuropathy and to test the effects of rest before and after an overwork period in rats with acrylamide neuropathy. The 4-week-old rats divided into four groups of eight rats. Acrylamide was administered to three groups (Groups 2, 3, and 4) to induce subacute paralysis followed by gradual ameriolation. Group 3 was exercised for the first 5 weeks and was rested for the last 5 weeks. Group 4 was exercised for the last 5 weeks. The diameter distribution of myelinated fibers of the tibial and sural nerves was analyzed. The percentage of larger myelinated fibers was decreased in all acrylamide-treated groups. The average values of fiber diameters in Group 4 were significantly smaller than injected sedentary animals (Group 2) or those with rest (Group 3), whereas no significant difference was found between the latter groups. Axonal degeneration of teased fibers was assessed in the tibial and sural nerves. The percentage of axonal degenerated fibers in exercised animals (Group 4) was significantly higher than in the other acrylamide-injected groups (Groups 2 and 3). This study supports the concept that acrylamide neuropathy worsens with moderate intensity of running activities for a prolonged period and that recovery may occur if vigorous exercise is avoided. JF - American journal of physical medicine & rehabilitation AU - Okajima, Y AU - Maloney, F P AD - John L McClellan Memorial Veterans Administration Hospital, Little Rock, Arkansas. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 66 EP - 69 VL - 68 IS - 2 SN - 0894-9115, 0894-9115 KW - Acrylamides KW - 0 KW - Acrylamide KW - 20R035KLCI KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Fatigue -- physiopathology KW - Animals KW - Sural Nerve -- pathology KW - Paralysis -- pathology KW - Rest KW - Nerve Fibers, Myelinated -- pathology KW - Paralysis -- physiopathology KW - Tibial Nerve -- pathology KW - Peripheral Nervous System Diseases -- physiopathology KW - Physical Exertion KW - Peripheral Nervous System Diseases -- pathology KW - Peripheral Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78943483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physical+medicine+%26+rehabilitation&rft.atitle=Overwork+weakness+in+rats+with+acrylamide+neuropathy.&rft.au=Okajima%2C+Y%3BMaloney%2C+F+P&rft.aulast=Okajima&rft.aufirst=Y&rft.date=1989-04-01&rft.volume=68&rft.issue=2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physical+medicine+%26+rehabilitation&rft.issn=08949115&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-12 N1 - Date created - 1989-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypersensitivity vasculitis associated with 2-deoxycoformycin and allopurinol therapy. AN - 78932450; 2784627 JF - The American journal of medicine AU - Steinmetz, J C AU - DeConti, R AU - Ginsburg, R AD - Albany Veterans Administration Medical Center, New York 12208. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 498 EP - 499 VL - 86 IS - 4 SN - 0002-9343, 0002-9343 KW - Ribonucleosides KW - 0 KW - Coformycin KW - 11033-22-0 KW - Pentostatin KW - 395575MZO7 KW - Allopurinol KW - 63CZ7GJN5I KW - Abridged Index Medicus KW - Index Medicus KW - Necrosis KW - Lung Neoplasms -- secondary KW - Humans KW - Lung Neoplasms -- drug therapy KW - Aged KW - Adenocarcinoma -- secondary KW - Adenocarcinoma -- drug therapy KW - Male KW - Ribonucleosides -- adverse effects KW - Drug Hypersensitivity -- etiology KW - Coformycin -- adverse effects KW - Arteritis -- chemically induced KW - Allopurinol -- adverse effects KW - Coformycin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78932450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Hypersensitivity+vasculitis+associated+with+2-deoxycoformycin+and+allopurinol+therapy.&rft.au=Steinmetz%2C+J+C%3BDeConti%2C+R%3BGinsburg%2C+R&rft.aulast=Steinmetz&rft.aufirst=J&rft.date=1989-04-01&rft.volume=86&rft.issue=4&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats. AN - 78923360; 2709684 AB - Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was studied in non-diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin (P). DM rats with mild glycosuria (similar in degree to that of the P treated animals) were also studied. Unanesthetized adult female, Sprague-Dawley rats were divided in four groups and studied for 15 days. Group 1 (P alone) received P, 360 mg/day, for 15 days; Group II (P + gentamicin); Group III (gentamicin alone) and Group IV (mild DM + gentamicin). Nephrotoxic doses (40 mg/kg body wt/day) of gentamicin were injected during the last nine days of study to the animals of groups II to IV. In Group I, P induced a moderate and stable glycosuria (3.9 +/- 0.1 g/day, SE), and no functional or morphologic evidence of renal dysfunction (baseline CCr 2.1 +/- 0.1 ml/min, undetectable lysozymuria) or damage (tubular necrosis score [maximum 4], zero). In Group II, P did not prevent gentamicin-ARF (maximal decrease in CCr at day 9.89%, P less than 0.001; peak lysozymuria, 1863 +/- 321 micrograms/day; and tubular necrosis score, 3.9 +/- 0.1). These values were not different from those of Group III: maximal decrease in CCr 73% (P less than 0.001); lysozymuria, 2147 +/- 701 micrograms/day; tubular necrosis score, 3.8 +/- 0.1.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Kidney international AU - Gouvea, W L AU - Alpert, H C AU - Kelley, J AU - Pardo, V AU - Vaamonde, C A AD - Medical Service, Veterans Administration Medical Center, Miami, Florida. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 1041 EP - 1048 VL - 35 IS - 4 SN - 0085-2538, 0085-2538 KW - Gentamicins KW - 0 KW - Phlorhizin KW - CU9S17279X KW - Index Medicus KW - Animals KW - Kidney -- pathology KW - Acute Kidney Injury -- prevention & control KW - Kidney Cortex -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Acute Kidney Injury -- chemically induced KW - Diabetes Mellitus, Experimental -- blood KW - Diabetes Mellitus, Experimental -- complications KW - Female KW - Kidney -- physiopathology KW - Diabetes Mellitus, Experimental -- physiopathology KW - Gentamicins -- toxicity KW - Gentamicins -- metabolism KW - Glycosuria -- physiopathology KW - Glycosuria -- blood KW - Glycosuria -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78923360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Phlorizin-induced+glycosuria+does+not+prevent+gentamicin+nephrotoxicity+in+rats.&rft.au=Gouvea%2C+W+L%3BAlpert%2C+H+C%3BKelley%2C+J%3BPardo%2C+V%3BVaamonde%2C+C+A&rft.aulast=Gouvea&rft.aufirst=W&rft.date=1989-04-01&rft.volume=35&rft.issue=4&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-01 N1 - Date created - 1989-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol intoxication: ion channels and genetics. AN - 78895730; 2467834 AB - Acute in vitro exposure to ethanol and other intoxicant-anesthetics activates gamma-aminobutyric acid (GABA)-stimulated chloride channels and inhibits voltage-dependent calcium and sodium channels of isolated brain membranes. The question of whether these neurochemical actions are responsible for intoxication in vivo has been addressed using animal populations displaying genetic differences in sensitivity to alcohol and benzodiazepine intoxication. These genetic approaches include inbred strains, selected lines, recombinant inbred strains, and heterogeneous stocks. Genetic differences in ion channel function provide strong evidence for a role of the GABA-stimulated chloride channel in ethanol and benzodiazepine intoxication; the role of calcium and sodium channels is less clear. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Harris, R A AU - Allan, A M AD - Denver Veterans Administration Medical Center, Colorado. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 1689 EP - 1695 VL - 3 IS - 6 SN - 0892-6638, 0892-6638 KW - Chloride Channels KW - 0 KW - Chlorides KW - Ion Channels KW - Membrane Proteins KW - Potassium Channels KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - gamma-Aminobutyric Acid -- pharmacology KW - Potassium Channels -- physiology KW - Mice KW - Chlorides -- physiology KW - Electrophysiology KW - Membrane Proteins -- physiology KW - Alcoholic Intoxication -- physiopathology KW - Ion Channels -- physiology KW - Alcoholic Intoxication -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78895730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Alcohol+intoxication%3A+ion+channels+and+genetics.&rft.au=Harris%2C+R+A%3BAllan%2C+A+M&rft.aulast=Harris&rft.aufirst=R&rft.date=1989-04-01&rft.volume=3&rft.issue=6&rft.spage=1689&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-15 N1 - Date created - 1989-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancer in Syrian golden hamsters with D-Trp-6-LH-RH and somatostatin analogue RC-160 microcapsules. AN - 78893374; 2564312 AB - Antitumoral effects of the agonist of luteinizing hormone-releasing hormone (D-Trp-6-LH-RH) and the somatostatin analog RC-160 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2) on chemically induced ductal pancreatic adenocarcinomas were studied. The tumors were induced in female Syrian golden hamsters by weekly s.c. injections of N-nitrosobis(2-oxopropyl)amine at a dose of 10 mg/kg b.w. for 6 weeks. 18 weeks after the last injection, the peptides in controlled-release microcapsule formulations were administered s.c. The animals received the following therapies: Group 1 (N = 15), vehicle only; Group 2 (N = 13), D-Trp-6-LH-RH microcapsules releasing 25 micrograms/day injected s.c. once a month; Group 3 (N = 14), RC-160 microcapsules, liberating 25 micrograms/day administered s.c. every 15 days; Group 4 (N = 14), the combination of D-Trp-6-LH-RH plus RC-160 microcapsules. The experiment was terminated on the 80th day when all hamsters in the control group were dead, but in the treated Groups 2, 3, and 4, we observed 71, 77, and 86% of survival rate, respectively. In addition to the prolongation of survival, the combination treatment resulted in a significant decrease in the tumorous pancreatic weight, increase in the body weight of the animals, reduction in ascites from 100 to 8.3% and regressive histological changes in 67% of the specimens. Our findings suggest that somatostatin analogues and D-Trp-6-LH-RH could be considered for the development of hormonal therapy for pancreatic cancer. JF - Cancer research AU - Zalatnai, A AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1989/04/01/ PY - 1989 DA - 1989 Apr 01 SP - 1810 EP - 1815 VL - 49 IS - 7 SN - 0008-5472, 0008-5472 KW - Antineoplastic Agents KW - 0 KW - Capsules KW - Nitrosamines KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Index Medicus KW - Animals KW - Neoplasm Metastasis KW - Mesocricetus KW - Female KW - Organ Size -- drug effects KW - Cricetinae KW - Pancreatic Neoplasms -- pathology KW - Antineoplastic Agents -- administration & dosage KW - Somatostatin -- therapeutic use KW - Pancreatic Neoplasms -- chemically induced KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Somatostatin -- analogs & derivatives KW - Somatostatin -- administration & dosage KW - Pancreatic Neoplasms -- drug therapy KW - Gonadotropin-Releasing Hormone -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78893374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Treatment+of+N-nitrosobis%282-oxopropyl%29amine-induced+pancreatic+cancer+in+Syrian+golden+hamsters+with+D-Trp-6-LH-RH+and+somatostatin+analogue+RC-160+microcapsules.&rft.au=Zalatnai%2C+A%3BSchally%2C+A+V&rft.aulast=Zalatnai&rft.aufirst=A&rft.date=1989-04-01&rft.volume=49&rft.issue=7&rft.spage=1810&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-05 N1 - Date created - 1989-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Res 1989 Sep 1;49(17):4946 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of hepatic failure toxins on regenerative enzymes in the liver after injury with galactosamine in the rat. AN - 78892057; 2703758 AB - Hepatic thymidine kinase (TK) and ornithine decarboxylase (ODC) activities were used to quantify the regenerative response to injury with galactosamine. After massive damage with 1000 mg/kg galactosamine, TK activity (DNA synthesis) peaked between 62 and 120 hours. This peak of activity was depressed as much as 91% by six subcoma doses of dimethyl disulfide (DMDS) given between 24 hours and 64 hours after galactosamine administration. Similar doses of octanoic acid (OA) had no effect, and doses of NH4Cl had no effect except at 120 hours. The first peak of ODC activity (initiation of cell growth) at 45 hours was depressed about 60% by six subcoma doses of NH4Cl or DMDS injected between 27 hours and 42 hours. OA again had no effect. After 400 mg/kg galactosamine, a narrow but high peak of TK activity occurred at 62 hours. This peak of activity was depressed more than 50% by six subcoma doses of NH4Cl, OA, or DMDS given between 24 hours and 54 hours. The first peak of ODC activity at 36 hours was similarly reduced by more than 50% by similar doses of each of the toxins given between 24 hours and 34 hours. The overt neurologic effects of the toxins were dissipated within 1 hour of each injection. The depressive effect of NH4Cl and OA on TK and ODC activities during regeneration after massive centrolobular injury with acetaminophen was more consistently present and more extensive than that seen after injury with galactosamine. JF - The Journal of laboratory and clinical medicine AU - Zieve, L AU - Dozeman, R AD - Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 463 EP - 468 VL - 113 IS - 4 SN - 0022-2143, 0022-2143 KW - Caprylates KW - 0 KW - Disulfides KW - Ornithine Decarboxylase Inhibitors KW - Ammonium Chloride KW - 01Q9PC255D KW - Acetaminophen KW - 362O9ITL9D KW - dimethyl disulfide KW - 3P8D642K5E KW - Galactosamine KW - 7535-00-4 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - octanoic acid KW - OBL58JN025 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Caprylates -- administration & dosage KW - Disulfides -- administration & dosage KW - Disulfides -- pharmacology KW - Chemical and Drug Induced Liver Injury KW - Ammonium Chloride -- pharmacology KW - Hepatic Encephalopathy -- enzymology KW - Hepatic Encephalopathy -- chemically induced KW - Rats, Inbred Strains KW - Rats KW - Ammonium Chloride -- administration & dosage KW - Time Factors KW - Male KW - Caprylates -- pharmacology KW - Liver Diseases -- enzymology KW - Liver Regeneration KW - Thymidine Kinase -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78892057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Effect+of+hepatic+failure+toxins+on+regenerative+enzymes+in+the+liver+after+injury+with+galactosamine+in+the+rat.&rft.au=Zieve%2C+L%3BDozeman%2C+R&rft.aulast=Zieve&rft.aufirst=L&rft.date=1989-04-01&rft.volume=113&rft.issue=4&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-12 N1 - Date created - 1989-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. AN - 78890980; 2703532 AB - Chronic ethanol feeding to rats increases the sinusoidal component of hepatic glutathione (GSH) efflux, despite a lower steady-state GSH pool size. In the present studies, no increase of biliary GSH efflux in vivo was found in chronic ethanol-fed cells. Studies were performed on ethanol-fed and pair-fed cells to identify the kinetic parameters of cellular GSH concentration-dependent efflux. The relationship between cytosolic GSH and the rate of efflux was modeled by the Hill equation, revealing a similar Vmax, 0.22 +/- 0.013 vs. 0.20 +/- 0.014 nmol/min per 10(6) cells for ethanol-fed and pair-fed cells, respectively, whereas the Km was significantly decreased (25.3 +/- 2.3 vs. 33.5 +/- 1.4 nmol/10(6) cells) in ethanol-fed cells. The difference in Km was larger when the data were corrected for the increased water content in ethanol-fed cells. We found a direct correlation between mitochondria and cytosolic GSH, revealing that mitochondria from ethanol-fed cells have less GSH at all cytosolic GSH values. The rate of resynthesis in depleted ethanol-fed cells in the presence of methionine and serine was similar to control cells and gamma-glutamylcysteine synthetase remained unaffected by chronic ethanol. However, the reaccumulation of mitochondrial GSH as the cytosolic pool increased was impaired in the ethanol cells. The earliest time change in GSH regulation was a 50% decrease in the mitochondrial GSH at 2 wk. JF - The Journal of clinical investigation AU - Fernandez-Checa, J C AU - Ookhtens, M AU - Kaplowitz, N AD - Liver Research Laboratory, Wadsworth Veterans Administration Medical Center, Los Angeles, California 90073. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 1247 EP - 1252 VL - 83 IS - 4 SN - 0021-9738, 0021-9738 KW - Glutathione KW - GAN16C9B8O KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Kinetics KW - Cell Compartmentation -- drug effects KW - Bile -- metabolism KW - Homeostasis -- drug effects KW - Male KW - Biological Transport -- drug effects KW - Cytosol -- metabolism KW - Mitochondria, Liver -- metabolism KW - Glutathione -- metabolism KW - Alcoholism -- metabolism KW - Mitochondria, Liver -- drug effects KW - Glutathione -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78890980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Effects+of+chronic+ethanol+feeding+on+rat+hepatocytic+glutathione.+Relationship+of+cytosolic+glutathione+to+efflux+and+mitochondrial+sequestration.&rft.au=Fernandez-Checa%2C+J+C%3BOokhtens%2C+M%3BKaplowitz%2C+N&rft.aulast=Fernandez-Checa&rft.aufirst=J&rft.date=1989-04-01&rft.volume=83&rft.issue=4&rft.spage=1247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-15 N1 - Date created - 1989-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Biochem. 1969 Mar;27(3):502-22 [4388022] Am J Physiol. 1988 Oct;255(4 Pt 1):G403-8 [3177640] Anal Biochem. 1980 Jul 15;106(1):55-62 [7416469] J Lab Clin Med. 1981 Sep;98(3):417-24 [7264437] J Biol Chem. 1982 Apr 10;257(7):3747-53 [7061508] J Pharmacol Exp Ther. 1983 Jan;224(1):141-7 [6848740] Biochem Pharmacol. 1983 Apr 15;32(8):1383-8 [6860357] Arch Biochem Biophys. 1983 Dec;227(2):534-41 [6320728] J Biol Chem. 1984 Aug 10;259(15):9355-8 [6746650] Anal Biochem. 1984 Sep;141(2):510-4 [6149706] J Clin Invest. 1985 Jan;75(1):258-65 [3965506] Proc Natl Acad Sci U S A. 1985 Jul;82(14):4668-72 [3860816] Biochem Pharmacol. 1986 Jan 1;35(1):7-13 [3940529] Proc Natl Acad Sci U S A. 1986 Mar;83(5):1246-50 [2869485] Am J Physiol. 1986 Feb;250(2 Pt 1):G236-43 [3953803] Arch Biochem Biophys. 1986 May 15;247(1):183-9 [3707139] Biochem Pharmacol. 1986 May 1;35(9):1533-7 [2871842] J Biol Chem. 1986 Jun 15;261(17):7860-5 [2872220] Am J Physiol. 1986 Sep;251(3 Pt 1):G354-61 [3752249] Biochem Biophys Res Commun. 1987 Feb 27;143(1):377-82 [3827928] J Clin Invest. 1987 Jul;80(1):57-62 [2885343] Arch Biochem Biophys. 1987 Aug 1;256(2):569-77 [3113336] J Clin Invest. 1988 Aug;82(2):608-16 [3403719] Methods Enzymol. 1978;52:60-71 [672656] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury. AN - 78889154; 2925247 AB - Tumor necrosis factor alpha (TNF-alpha) mediates components of the acute-phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied whether human recombinant TNF-alpha (rTNF-alpha) could increase pulmonary edema formation and pulmonary vascular permeability. Rabbits preinfused with 125I-albumin were administered rTNF-alpha or saline. Animals were sacrificed, and lung wet/dry weight ratios as well as bronchoalveolar lavage fluid and plasma 125I activities were determined. rTNF-alpha increased lung wet/dry weight ratios by 151% (P less than 0.02) and bronchoalveolar lavage fluid/plasma 125I activity ratios by 376% (P less than 0.01) compared with values for saline controls. Electron microscopy of lung sections demonstrated endothelial injury, perivascular edema, and extravasation of an ultrastructural permeability tracer. To demonstrate that rTNF-alpha could directly increase pulmonary vascular endothelial permeability in vitro, we studied albumin transfer across cultured porcine pulmonary artery endothelial cell monolayers. rTNF-alpha induced time-dependent dose-response increments in transendothelial albumin flux in the absence of granulocyte effector cells. These observations suggest that rTNF-alpha can provoke acute pulmonary vascular endothelial injury in vivo as well as in vitro. JF - Infection and immunity AU - Goldblum, S E AU - Hennig, B AU - Jay, M AU - Yoneda, K AU - McClain, C J AD - Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 1218 EP - 1226 VL - 57 IS - 4 SN - 0019-9567, 0019-9567 KW - Recombinant Proteins KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Swine KW - Recombinant Proteins -- toxicity KW - Leukocyte Count -- drug effects KW - Animals KW - Cells, Cultured KW - Humans KW - Lung -- ultrastructure KW - Granulocytes -- pathology KW - Granulocytes -- drug effects KW - Rabbits KW - Capillary Permeability -- drug effects KW - Bronchoalveolar Lavage Fluid -- physiopathology KW - Tumor Necrosis Factor-alpha -- toxicity KW - Endothelium, Vascular -- drug effects KW - Pulmonary Edema -- chemically induced KW - Endothelium, Vascular -- pathology KW - Endothelium, Vascular -- ultrastructure KW - Pulmonary Edema -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78889154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Tumor+necrosis+factor+alpha-induced+pulmonary+vascular+endothelial+injury.&rft.au=Goldblum%2C+S+E%3BHennig%2C+B%3BJay%2C+M%3BYoneda%2C+K%3BMcClain%2C+C+J&rft.aulast=Goldblum&rft.aufirst=S&rft.date=1989-04-01&rft.volume=57&rft.issue=4&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-05 N1 - Date created - 1989-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1987 Jan 15;142(1):235-41 [3028403] J Immunol. 1987 Feb 1;138(3):765-74 [3100615] J Immunol. 1987 Apr 1;138(7):2137-42 [3494060] J Immunol. 1987 Apr 1;138(7):2143-8 [3494061] J Exp Med. 1969 May 1;129(5):833-48 [4888307] Lab Invest. 1971 Apr;24(4):318-20 [4933764] Science. 1974 Mar 15;183(4129):1085-7 [4812036] Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 [1103152] J Clin Invest. 1981 Nov;68(5):1253-60 [7298850] N Engl J Med. 1982 Apr 15;306(15):900-9 [7038493] Am Rev Respir Dis. 1982 Apr;125(4):443-7 [7073114] Ann N Y Acad Sci. 1982;384:287-300 [6953825] Arteriosclerosis. 1984 Sep-Oct;4(5):489-97 [6477300] Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9 [6392892] J Biol Chem. 1985 Feb 25;260(4):2345-54 [3871770] J Clin Invest. 1985 Mar;75(3):902-10 [3980730] J Immunol. 1985 Sep;135(3):2069-73 [3926894] Science. 1985 Aug 30;229(4716):869-71 [3895437] J Immunol. 1985 Dec;135(6):3972-7 [2999236] J Exp Med. 1985 Dec 1;162(6):2163-8 [2999289] J Appl Physiol (1985). 1985 Dec;59(6):1978-85 [3001018] Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667-71 [3866246] J Immunol. 1986 Mar 1;136(5):1680-7 [3485132] J Exp Med. 1986 Mar 1;163(3):740-5 [3753996] Am J Pathol. 1986 Apr;123(1):16-24 [2421578] J Immunol. 1986 Jun 1;136(11):4220-5 [3009619] J Immunol. 1986 Jun 15;136(12):4548-53 [3486903] J Exp Med. 1986 Jun 1;163(6):1363-75 [3011946] J Exp Med. 1986 Jun 1;163(6):1433-50 [3486936] J Natl Cancer Inst. 1986 Jun;76(6):1113-21 [3458948] Proc Natl Acad Sci U S A. 1986 Jun;83(12):4533-7 [3487091] Am J Pathol. 1986 Aug;124(2):179-85 [3526909] J Immunol. 1986 Nov 1;137(9):2980-4 [3093587] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7467-71 [3489939] J Appl Physiol (1985). 1987 Nov;63(5):2093-100 [3500942] J Clin Invest. 1988 Apr;81(4):1162-72 [3258319] Biochem J. 1988 Feb 15;250(1):125-32 [3128274] N Engl J Med. 1988 Jun 9;318(23):1481-6 [2835680] Infect Immun. 1988 Sep;56(9):2255-63 [3261716] Am Rev Respir Dis. 1988 Jun;137(6):1364-70 [3059859] Science. 1986 Oct 24;234(4775):470-4 [3764421] J Clin Invest. 1986 Nov;78(5):1349-54 [2429991] J Immunol Methods. 1986 Nov 6;93(2):201-6 [3772113] J Appl Physiol (1985). 1987 Jan;62(1):122-8 [3031000] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes. AN - 78887965; 2564005 AB - Receptors for 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] are expressed upon activation of human lymphocytes, and the hormone inhibits in vitro the proliferation of mitogen-activated lymphocytes. In this study we examined the distribution of the 1,25-(OH)2D3 receptor protein in the two major subsets of T lymphocytes (T helper and T suppressor cells) and the effect of the hormone on their respective rates of proliferation. We activated normal lymphocytes in the presence of monocytes with phytohemagglutinin and subsequently isolated the T helper (T4-positive) and the T suppressor (T8-positive) subsets using monoclonal antibodies and complement-mediated lysis. In parallel experiments, we first isolated monocyte-depleted T4 and T8 cells and then activated them using phytohemagglutinin and a phorbol ester. Using either approach we found that both T4 and T8 lymphocytes expressed the 1,25-(OH)2D3 receptor protein upon activation. The concentration of this protein, its affinity for the ligand (Kd, approximately 10(-10) mol/L), and its sedimentation characteristics (S = 3.3) were indistinguishable in the two T cell subsets. Furthermore, the time kinetics of expression of the receptor after activation were very similar in the two subsets. Nevertheless, 1,25-(OH)2D3 inhibited in a dose-dependent fashion the rate of proliferation of the helper subset, but had no effect on the proliferation of suppressor cells. The finding of a dissimilar effect of 1,25-(OH)2D3 on the proliferation of the T helper and T suppressor cells despite their indistinguishable receptor status suggests that the 1,25-(OH)2D3 receptors of the T cells might not be involved in the effects of the hormone on T-cell proliferation, and that the 1,25-(OH)2D3-induced inhibition of mitogen-activated T4 cell proliferation could be mediated indirectly. JF - The Journal of clinical endocrinology and metabolism AU - Provvedini, D M AU - Manolagas, S C AD - Section of Endocrinology and Metabolism, Veterans Administration Medical Center, Indianapolis, Indiana 46202. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 774 EP - 779 VL - 68 IS - 4 SN - 0021-972X, 0021-972X KW - Antigens, CD8 KW - 0 KW - Antigens, Differentiation, T-Lymphocyte KW - Phorbol Esters KW - Phytohemagglutinins KW - Receptors, Calcitriol KW - Receptors, Steroid KW - Calcitriol KW - FXC9231JVH KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Cell Division -- drug effects KW - CD4-Positive T-Lymphocytes -- immunology KW - Cell Separation KW - Phytohemagglutinins -- pharmacology KW - Calcitriol -- pharmacology KW - Lymphocyte Activation -- drug effects KW - Phorbol Esters -- pharmacology KW - Flow Cytometry KW - Antigens, Differentiation, T-Lymphocyte -- immunology KW - Female KW - Male KW - T-Lymphocytes -- metabolism KW - T-Lymphocytes, Regulatory -- drug effects KW - Receptors, Steroid -- drug effects KW - T-Lymphocytes, Helper-Inducer -- drug effects KW - Receptors, Steroid -- metabolism KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes, Helper-Inducer -- metabolism KW - T-Lymphocytes, Regulatory -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78887965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=1+Alpha%2C25-dihydroxyvitamin+D3+receptor+distribution+and+effects+in+subpopulations+of+normal+human+T+lymphocytes.&rft.au=Provvedini%2C+D+M%3BManolagas%2C+S+C&rft.aulast=Provvedini&rft.aufirst=D&rft.date=1989-04-01&rft.volume=68&rft.issue=4&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Significance of low serum urea nitrogen concentrations. AN - 78886124; 2702749 AB - The prevalence of low serum urea nitrogen concentrations (less than 50 mg/L) in our patient population was 1.2% (151 per 12,380 determinations), representing 95 individual cases. Of these, 81 of the patients' charts were located, reviewed, and classified into two groups, those with and those without hepatobiliary disease. Hepatobiliary disease was found in 36% of the 81 patients; 90% of these showed evidence of alcohol abuse, as did 19% of those without hepatobiliary disease. The remaining patients without hepatobiliary disease had various clinical conditions: psychiatric disorders (14.8%), overhydration (12.3%), endocrine disorders (7.4%), cardiovascular diseases (4.9%), prednisone administration (3.7%), and special diets (2.5%). Thus, in our patient population the most frequent cause of low serum urea nitrogen concentrations was alcohol abuse, found in about half of the cases. JF - Clinical chemistry AU - Lum, G AU - Leal-Khouri, S AD - Laboratory Service, Brockton/West Roxbury Veterans Administration Medical Center, MA. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 639 EP - 640 VL - 35 IS - 4 SN - 0009-9147, 0009-9147 KW - Index Medicus KW - Mental Disorders -- blood KW - Reference Values KW - Cholelithiasis -- blood KW - Cardiovascular Diseases -- blood KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Endocrine System Diseases -- blood KW - Alcoholism -- blood KW - Liver Diseases -- blood KW - Biliary Tract Diseases -- blood KW - Blood Urea Nitrogen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78886124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Significance+of+low+serum+urea+nitrogen+concentrations.&rft.au=Lum%2C+G%3BLeal-Khouri%2C+S&rft.aulast=Lum&rft.aufirst=G&rft.date=1989-04-01&rft.volume=35&rft.issue=4&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-22 N1 - Date created - 1989-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mania secondary to amantadine treatment of neuroleptic-induced hyperprolactinemia. AN - 78877362; 2564388 AB - The authors report a case of mania secondary to amantadine in a patient for whom amantadine was used to treat galactorrhea and amenorrhea. Attempts to treat the mania and endocrine symptoms simultaneously and the biological implications are discussed. JF - The Journal of clinical psychiatry AU - Rego, M D AU - Giller, E L AD - West Haven Veterans Administration Medical Center, New Haven, Ct. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 143 EP - 144 VL - 50 IS - 4 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - Galactorrhea -- drug therapy KW - Humans KW - Adult KW - Amenorrhea -- drug therapy KW - Female KW - Bipolar Disorder -- drug therapy KW - Amantadine -- adverse effects KW - Hyperprolactinemia -- drug therapy KW - Hyperprolactinemia -- chemically induced KW - Antipsychotic Agents -- adverse effects KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78877362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Mania+secondary+to+amantadine+treatment+of+neuroleptic-induced+hyperprolactinemia.&rft.au=Rego%2C+M+D%3BGiller%2C+E+L&rft.aulast=Rego&rft.aufirst=M&rft.date=1989-04-01&rft.volume=50&rft.issue=4&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-11 N1 - Date created - 1989-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aldosterone-induced proteins: purification and localization of GP65,70. AN - 75768405; 2495728 AB - Aldosterone stimulates sodium transport in responsive epithelia by inducing "effector" proteins that control or modulate transcellular sodium flux. We have previously identified a group of electrophoretically microheterogeneous (pI 5.8-6.2) and polymorphic (Mr 65 and 70) glycoproteins that are specifically induced by aldosterone in toad urinary bladders (TUBs) and cultured toad kidney cells (A6 cell line). We raised a series of monoclonal antibodies (MAb) to these proteins and, using light and electron immunohistochemistry, localized the higher Mr glycoproteins (GP70) to the apical plasma membrane and subapical granules of the sodium-transporting cell of the TUB epithelium, the granular cell. GP70 appears to be discharged into the bladder lumen; this process is increased by phorbol myristate acetate, an agent known to induce granule exocytosis. These findings are consistent with the possibility that GP70 represent components or modulators of the "high-resistance" renal epithelial sodium channel. MAbs reactive against GP65 did not identify these glycoproteins within TUB epithelial cells; these lower Mr aldosterone-induced proteins may be incompletely processed forms of GP70. JF - The American journal of physiology AU - Szerlip, H M AU - Weisberg, L AU - Clayman, M AU - Neilson, E AU - Wade, J B AU - Cox, M AD - Renal Electrolyte Section, Veterans Administration Medical Center, Philadelphia, Pennsylvania. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - C865 EP - C872 VL - 256 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Antibodies, Monoclonal KW - 0 KW - Glycoproteins KW - Wheat Germ Agglutinins KW - Aldosterone KW - 4964P6T9RB KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Cytoplasmic Granules -- analysis KW - Histocytochemistry KW - Cell Membrane -- analysis KW - Bufo marinus KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Immunosorbent Techniques KW - Microscopy, Electron KW - Female KW - Immunoenzyme Techniques KW - Glycoproteins -- biosynthesis KW - Glycoproteins -- analysis KW - Urinary Bladder -- ultrastructure KW - Kidney -- analysis KW - Kidney -- drug effects KW - Aldosterone -- pharmacology KW - Kidney -- ultrastructure KW - Urinary Bladder -- analysis KW - Urinary Bladder -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75768405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Aldosterone-induced+proteins%3A+purification+and+localization+of+GP65%2C70.&rft.au=Szerlip%2C+H+M%3BWeisberg%2C+L%3BClayman%2C+M%3BNeilson%2C+E%3BWade%2C+J+B%3BCox%2C+M&rft.aulast=Szerlip&rft.aufirst=H&rft.date=1989-04-01&rft.volume=256&rft.issue=4+Pt+1&rft.spage=C865&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein kinase inhibitor prevents pulmonary edema in response to H2O2. AN - 75766662; 2705544 AB - We investigated the effect of H2O2 (92 microM) in isolated guinea pig lungs perfused with a buffered Ringer solution. Pulmonary arterial pressure (Ppa), pulmonary capillary pressure (Ppc), and change in lung weight (delta W) were recorded at 0 min and at 15, 30, and 60 min after the H2O2. The capillary filtration coefficient (Kfc) was measured at 0 and 30 min. The perfusion of H2O2 increased the Ppa, Ppc, delta W, and Kfc. The thromboxane synthetase inhibitor Dazoxiben, or the vasodilator papaverine, prevented the increases in Ppa and Ppc. The protein kinase C (PKC) inhibitor H7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride] prevented the increases in Ppa, Ppc, delta W, and Kfc, whereas the inactive isoquinoline HA1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride] had little effect on the H2O2 response. H2O2 increased the number of stress fibers and disrupted the peripheral band of cultured confluent endothelial cells, changes that were prevented with pretreatment with H7. PKC may mediate the increases in vascular permeability and pulmonary edema that occur in response to H2O2. JF - The American journal of physiology AU - Johnson, A AU - Phillips, P AU - Hocking, D AU - Tsan, M F AU - Ferro, T AD - Research Service, Veterans Administration Medical Center, Albany, New York. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - H1012 EP - H1022 VL - 256 IS - 4 Pt 2 SN - 0002-9513, 0002-9513 KW - Imidazoles KW - 0 KW - Isoquinolines KW - Piperazines KW - dazoxiben KW - 09ZFC7974Q KW - Thromboxane A2 KW - 57576-52-0 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Protein Kinase C KW - EC 2.7.11.13 KW - Thromboxane-A Synthase KW - EC 5.3.99.5 KW - Index Medicus KW - Animals KW - Imidazoles -- pharmacology KW - Guinea Pigs KW - Capillary Permeability KW - Thromboxane-A Synthase -- antagonists & inhibitors KW - Pulmonary Artery -- ultrastructure KW - Endothelium, Vascular -- ultrastructure KW - Thromboxane A2 -- physiology KW - Male KW - Female KW - Cytoskeleton -- drug effects KW - Pulmonary Edema -- prevention & control KW - Hydrogen Peroxide -- toxicity KW - Isoquinolines -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Pulmonary Edema -- chemically induced KW - Protein Kinase C -- physiology KW - Piperazines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75766662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Protein+kinase+inhibitor+prevents+pulmonary+edema+in+response+to+H2O2.&rft.au=Johnson%2C+A%3BPhillips%2C+P%3BHocking%2C+D%3BTsan%2C+M+F%3BFerro%2C+T&rft.aulast=Johnson&rft.aufirst=A&rft.date=1989-04-01&rft.volume=256&rft.issue=4+Pt+2&rft.spage=H1012&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-12 N1 - Date created - 1989-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ability of prostaglandin to reduce ethanol injury to dispersed chief cells from guinea pig stomach. AN - 75766510; 2495731 AB - To determine whether prostaglandin exerts a direct action on individual gastric epithelial cells that protects them from ethanol-induced injury, dispersed chief cells from guinea pig stomach were pretreated with 16,16-dimethyl-prostaglandin E2 (dmPGE2) or placebo before incubation with ethanol or control. Cell injury was assessed in terms of exclusion of Fast Green dye, release of lactate dehydrogenase, alterations of ultrastructure, and pepsinogen secretion stimulated by a variety of secretagogues. Of chief cells 60 +/- 2% were stained by Fast Green if incubated with 10% ethanol for 1 h after pretreatment with placebo, whereas only 38 +/- 1% of cells showed Fast Green staining when pretreated with 2.6 microM dmPGE2 before ethanol exposure. Similarly, 63 +/- 2% of cellular lactate dehydrogenase was released from chief cells pretreated with placebo compared with 36 +/- 4% of lactate dehydrogenase released from cells pretreated with 2.6 microM dmPGE2 (P less than 0.01). The prostaglandin's protective effect persisted throughout a 6-h incubation with ethanol. Scanning and transmission electron micrographs demonstrated disintegration of chief cells pretreated with placebo before ethanol exposure, whereas ultrastructural architecture was relatively preserved among chief cells pretreated with dmPGE2. Preincubation with 8 or 10% ethanol inhibited the subsequent stimulation of pepsinogen secretion caused by carbachol, cholecystokinin, A23187, 12-O-tetradecanoylphorbol 13-acetate, forskolin, or 8-bromoadenosine 3',5'-cyclic monophosphate. Pretreatment with dmPGE2 did not reduce the ethanol-induced inhibition of secretion stimulated by any of these secretagogues. These data indicate that dmPGE2 significantly reduces ethanol-induced damage to dispersed chief cells in terms of alterations of membrane permeability and ultrastructure but does not prevent the ethanol-induced impairment of pepsinogen secretion. These findings provide evidence that dmPGE2 exerts a direct but limited protective action on the gastric chief cell, independent of vascular, paracrine, or neural actions. JF - The American journal of physiology AU - Cherner, J A AU - Naik, L AU - Tarnawski, A AU - Brzozowski, T AU - Stachura, J AU - Singh, G AD - Gastroenterology Section, Veterans Administration Medical Center, Long Beach 90822. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - G704 EP - G714 VL - 256 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Pepsinogens KW - 0 KW - Prostaglandins E, Synthetic KW - Rosaniline Dyes KW - Colforsin KW - 1F7A44V6OU KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Calcimycin KW - 37H9VM9WZL KW - Ethanol KW - 3K9958V90M KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone KW - 555-60-2 KW - Carbachol KW - 8Y164V895Y KW - Fast Green KW - 9J3VQ0Y6BV KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Sincalide KW - M03GIQ7Z6P KW - 16,16-Dimethylprostaglandin E2 KW - M790V82VAC KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Rosaniline Dyes -- metabolism KW - Calcimycin -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Sincalide -- pharmacology KW - Colforsin -- pharmacology KW - Cell Membrane Permeability -- drug effects KW - Pepsinogens -- secretion KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Microscopy, Electron KW - Carbachol -- pharmacology KW - Female KW - L-Lactate Dehydrogenase -- metabolism KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone -- pharmacology KW - Microscopy, Electron, Scanning KW - Gastric Mucosa -- ultrastructure KW - Ethanol -- pharmacology KW - Prostaglandins E, Synthetic -- pharmacology KW - Gastric Mucosa -- drug effects KW - 16,16-Dimethylprostaglandin E2 -- pharmacology KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75766510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Ability+of+prostaglandin+to+reduce+ethanol+injury+to+dispersed+chief+cells+from+guinea+pig+stomach.&rft.au=Cherner%2C+J+A%3BNaik%2C+L%3BTarnawski%2C+A%3BBrzozowski%2C+T%3BStachura%2C+J%3BSingh%2C+G&rft.aulast=Cherner&rft.aufirst=J&rft.date=1989-04-01&rft.volume=256&rft.issue=4+Pt+1&rft.spage=G704&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hyperthyroxinemia in patients receiving thyroid replacement therapy. AN - 75766403; 2705841 AB - Eleven patients, with a history of hypothyroidism, who had hyperthyroxinemia and an elevated free thyroxine index but normal serum triiodothyronine concentrations on levothyroxine replacement underwent levothyroxine dose reduction at three-month intervals until the free thyroxine index fell into the normal range. All were clinically euthyroid throughout. Normalization of the thyrotropin response to thyrotropin-releasing hormone occurred concomitantly, indicating correction of subtle hyperthyroidism. The mean thyroxine dose decreased from 161 micrograms/d (2.06 micrograms/kg) to 120 micrograms/d (1.51 micrograms/kg). The resting heart rate fell in eight of 11 patients (P less than .02). The left ventricular ejection fraction decreased in eight of 11 patients, although the decrease was not statistically significant. Considering the sensitivity of pituitary, cardiac, and bone tissue to even a small excess of thyroxine over time, hyperthyroxinemia associated with an elevated free thyroxine index should be corrected even in patients taking levothyroxine replacement who are clinically euthyroid and whose serum triiodothyronine concentrations are within normal limits. JF - Archives of internal medicine AU - Grund, F M AU - Niewoehner, C B AD - Department of Nuclear Medicine, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 921 EP - 924 VL - 149 IS - 4 SN - 0003-9926, 0003-9926 KW - Triiodothyronine KW - 06LU7C9H1V KW - Creatinine KW - AYI8EX34EU KW - Thyroxine KW - Q51BO43MG4 KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Triiodothyronine -- blood KW - Humans KW - Body Weight -- drug effects KW - Adult KW - Aged KW - Creatinine -- blood KW - Male KW - Female KW - Hyperthyroxinemia -- chemically induced KW - Hypothyroidism -- drug therapy KW - Thyroxine -- administration & dosage KW - Thyroxine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75766403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Hyperthyroxinemia+in+patients+receiving+thyroid+replacement+therapy.&rft.au=Grund%2C+F+M%3BNiewoehner%2C+C+B&rft.aulast=Grund&rft.aufirst=F&rft.date=1989-04-01&rft.volume=149&rft.issue=4&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sex hormone-mediated effects on the phase I and phase II metabolism of N-2-fluorenylacetamide. Modulation of 9-hydroxylation. AN - 75764988; 2495797 AB - Sex differences in the phase I (cytochrome P-450-catalyzed hydroxylations) and phase II (conjugations) metabolism of N-2-fluorenylacetamide (2-FAA) by the livers of 50-day-old Sprague-Dawley rats and effects of gonadectomy were determined. The higher level (1.4 times) of cytochrome P-450 in the microsomes of male rats correlated with their 8 and 1.3 times greater capacities to form 9-hydroxy(OH)-2-FAA and 7-OH-2-FAA respectively. One week after gonadectomy, the formation of 9-OH-2-FAA, the major metabolite in the male, was decreased by 70%, whereas in the female it was increased 1.3 times. Treatment of male rats with beta-naphthoflavone (beta-NF) increased the formation of phenolic metabolites and N-OH-2-FAA, but decreased that of 9-OH-2-FAA. The amounts of 9-OH-2-FAA were increased, however, in beta-NF-treated female and gonadectomized male rats. These sex hormone- and beta-NF-mediated differences in the extent of 9-hydroxylation of 2-FAA are discussed in relation to the fluctuations in the levels of specific cytochrome P-450 isozymes. In contrast to the phenolic metabolites and N-OH-2-FAA, 9-OH-2-FAA was a poor substrate for UDP-glucuronyltransferase; this conjugation was not induced by treatment of male rats with beta-NF. Hence, in the presence of male hormones, relatively large amounts of 9-OH-2-FAA were formed and possibly retained in the liver. A role of this alcohol as a potential promoter in hepatocarcinogenesis by 2-FAA is suggested. JF - Biochemical pharmacology AU - Malejka-Giganti, D AU - Magat, W J AU - Decker, R W AD - Laboratory for Cancer Research, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1989/04/01/ PY - 1989 DA - 1989 Apr 01 SP - 1075 EP - 1082 VL - 38 IS - 7 SN - 0006-2952, 0006-2952 KW - Benzoflavones KW - 0 KW - Cytochrome b Group KW - Gonadal Steroid Hormones KW - Hydroxyacetylaminofluorene KW - 53-95-2 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Cytochromes b5 KW - 9035-39-6 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Mixed Function Oxygenases KW - EC 1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Index Medicus KW - Animals KW - Cytochrome b Group -- metabolism KW - Sex Factors KW - Cytochrome P-450 Enzyme System -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Hydroxylation KW - Orchiectomy KW - Rats, Inbred Strains KW - Rats KW - Mixed Function Oxygenases -- metabolism KW - Ovariectomy KW - Female KW - Male KW - Benzoflavones -- pharmacology KW - Hydroxyacetylaminofluorene -- metabolism KW - 2-Acetylaminofluorene -- toxicity KW - 2-Acetylaminofluorene -- metabolism KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- enzymology KW - Gonadal Steroid Hormones -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75764988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Sex+hormone-mediated+effects+on+the+phase+I+and+phase+II+metabolism+of+N-2-fluorenylacetamide.+Modulation+of+9-hydroxylation.&rft.au=Malejka-Giganti%2C+D%3BMagat%2C+W+J%3BDecker%2C+R+W&rft.aulast=Malejka-Giganti&rft.aufirst=D&rft.date=1989-04-01&rft.volume=38&rft.issue=7&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-12 N1 - Date created - 1989-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Variability of serum phenytoin concentrations in nursing home patients. AN - 75764519; 2705838 AB - A marked variability in serum phenytoin concentrations was observed in an elderly nursing home resident. To determine the prevalence of this problem, 15 frail nursing home patients who were receiving phenytoin therapy were studied over a mean follow-up period of 10.6 +/- 0.89 months. The mean number of serum phenytoin level measurements during this period was 13.1 +/- 1.5. For a given individual, there was no variation in phenytoin dose or preparation administered. All the patients had a difference of more than 50% between the highest and the lowest serum phenytoin levels, and in five patients (33%), the difference exceeded 150%. The change in serum phenytoin level was temporally related to influenza vaccination in only three patients. The form of phenytoin was not a significant determinant of the variability in this patient population, nor did enteral feeding have any effect. It is recommended that nursing home patients receiving phenytoin therapy have periodic serum phenytoin measurements obtained, even in the absence of seizures or classic signs of phenytoin toxicity. JF - Archives of internal medicine AU - Mooradian, A D AU - Hernandez, L AU - Tamai, I C AU - Marshall, C AD - Geriatric Research, Education and Clinical Center, Sepulveda (Calif) Veterans Administration Medical Center. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 890 EP - 892 VL - 149 IS - 4 SN - 0003-9926, 0003-9926 KW - Phenytoin KW - 6158TKW0C5 KW - Abridged Index Medicus KW - Index Medicus KW - California KW - Aged, 80 and over KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Homes for the Aged KW - Phenytoin -- blood KW - Nursing Homes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75764519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Variability+of+serum+phenytoin+concentrations+in+nursing+home+patients.&rft.au=Mooradian%2C+A+D%3BHernandez%2C+L%3BTamai%2C+I+C%3BMarshall%2C+C&rft.aulast=Mooradian&rft.aufirst=A&rft.date=1989-04-01&rft.volume=149&rft.issue=4&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1990 Sep;150(9):1971, 1974 [2393333] Arch Intern Med. 1990 Apr;150(4):918-9 [2327857] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells. AN - 75764336; 2468293 AB - We examined regulation of histamine release from canine hepatic and fundic mucosal mast cells in short-term culture. We found that beta- but not alpha-adrenergic agonists markedly inhibited concanavalin A (ConA)-stimulated histamine release. Inhibition by epinephrine was reversed by the beta-antagonist propranolol, but not by the alpha-adrenergic antagonists phentolamine or yohimbine. The beta 2-selective antagonist ICI 115881 reversed the effects of epinephrine, whereas the beta 1-antagonists practolol and betaxolol had little effect. Prostaglandin E2 (PGE2), but not its analogue enprostil, inhibited ConA-stimulated histamine release. This difference may relate to the ability of PGE2, but not enprostil, to stimulate adenosine 3',5'-cyclic monophosphate (cAMP) production. Forskolin, cAMP analogues, and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine also effectively inhibited ConA-stimulated histamine release. Neither adrenergic agonists nor PGE2 inhibited histamine release stimulated by the combination of phorbol 12-myristate-13-acetate plus the calcium ionophore A23187. These data suggest that inhibition was mediated via cAMP-dependent mechanisms and was exerted on primary cell activation, rather than on postreceptor activating events. JF - The American journal of physiology AU - Soll, A H AU - Toomey, M AD - Center for Ulcer Research and Education, Veterans Administration Wadsworth Hospital Center, Los Angeles, California. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - G727 EP - G732 VL - 256 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Adrenergic beta-Antagonists KW - 0 KW - Propanolamines KW - Prostaglandins E, Synthetic KW - Concanavalin A KW - 11028-71-0 KW - Colforsin KW - 1F7A44V6OU KW - Calcimycin KW - 37H9VM9WZL KW - ICI 118551 KW - 46OL1UC10R KW - Propranolol KW - 9Y8NXQ24VQ KW - Cyclic AMP KW - E0399OZS9N KW - Enprostil KW - J4IP5Z9DAU KW - Dinoprostone KW - K7Q1JQR04M KW - Isoproterenol KW - L628TT009W KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Animals KW - Cyclic AMP -- biosynthesis KW - Liver -- cytology KW - Propranolol -- pharmacology KW - Calcimycin -- pharmacology KW - Isoproterenol -- pharmacology KW - Colforsin -- pharmacology KW - Gastric Fundus -- cytology KW - Epinephrine -- pharmacology KW - Prostaglandins E, Synthetic -- pharmacology KW - Dogs KW - Tetradecanoylphorbol Acetate -- pharmacology KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Propanolamines -- pharmacology KW - Concanavalin A -- pharmacology KW - Dinoprostone -- pharmacology KW - Mast Cells -- physiology KW - Gastric Mucosa -- cytology KW - Mast Cells -- drug effects KW - Histamine Release -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75764336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Beta-adrenergic+and+prostanoid+inhibition+of+canine+fundic+mucosal+mast+cells.&rft.au=Soll%2C+A+H%3BToomey%2C+M&rft.aulast=Soll&rft.aufirst=A&rft.date=1989-04-01&rft.volume=256&rft.issue=4+Pt+1&rft.spage=G727&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Barbiturate-related connective tissue disorders. AN - 75763680; 2705840 AB - Development of Dupuytren's contractures, frozen shoulder, Ledderhose's syndrome, Peyronie's disease, fibromas, and general joint pain has been linked in retrospective studies and case reports to the use of antiepileptic drugs. We undertook a prospective survey of the incidence of connective tissue disorders in 622 patients newly treated with carbamazepine, phenobarbital, phenytoin sodium, or primidone. Ten of the 406 patients who were treated for 6 months or more developed connective tissue disorders. All affected patients were taking a barbiturate (primidone, 4 patients; phenobarbital, 6 patients). Seven of the 10 problems occurred during the first year of treatment. These data are prospective evidence of a statistically significant relationship between barbiturate use and the development of connective tissue disorders, and timing of appearance. JF - Archives of internal medicine AU - Mattson, R H AU - Cramer, J A AU - McCutchen, C B AD - Epilepsy Center, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 911 EP - 914 VL - 149 IS - 4 SN - 0003-9926, 0003-9926 KW - Anticonvulsants KW - 0 KW - Barbiturates KW - Primidone KW - 13AFD7670Q KW - Carbamazepine KW - 33CM23913M KW - Phenytoin KW - 6158TKW0C5 KW - Phenobarbital KW - YQE403BP4D KW - Abridged Index Medicus KW - Index Medicus KW - Carbamazepine -- adverse effects KW - Prospective Studies KW - Phenobarbital -- adverse effects KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Phenytoin -- adverse effects KW - Primidone -- adverse effects KW - Male KW - Female KW - Barbiturates -- adverse effects KW - Connective Tissue Diseases -- chemically induced KW - Anticonvulsants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75763680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Barbiturate-related+connective+tissue+disorders.&rft.au=Mattson%2C+R+H%3BCramer%2C+J+A%3BMcCutchen%2C+C+B&rft.aulast=Mattson&rft.aufirst=R&rft.date=1989-04-01&rft.volume=149&rft.issue=4&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Catholicism and Early Adult Foster Care AN - 61541845; 199001595 AB - Early Catholic Church ideas of the nature of God & of the Church & its obligation to provide for the dependent out of a sense of justice, together with the notion of the communion of saints & devotion to them, set the stage historically for adult foster care. Devotion to Saint Dympna in the thirteenth century, a time of Church ferment, occasioned the taking of mentally ill pilgrims into private homes in Gheel, Belgium. After the Reformation, the influence of the Church declined with the rise of capitalism & the secular state. However, its beliefs & practices created the circumstances for the adult foster care prototype & suggest that a larger power has a role, as the Church did then, in providing for needs that surpass an individual's ability to cope. 25 References. HA JF - Adult Residential Care Journal AU - Miller, Mark C AD - Veterans Administration Medical Center, Chillicothe OH 45601 Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 6 EP - 13 VL - 3 IS - 1 SN - 0899-1995, 0899-1995 KW - adult foster care, 13th-century Catholic Church's influence, Gheel, Belgium KW - Middle Ages KW - Belgium KW - Roman Catholics KW - Adults KW - Foster Care KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61541845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adult+Residential+Care+Journal&rft.atitle=Catholicism+and+Early+Adult+Foster+Care&rft.au=Miller%2C+Mark+C&rft.aulast=Miller&rft.aufirst=Mark&rft.date=1989-04-01&rft.volume=3&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Adult+Residential+Care+Journal&rft.issn=08991995&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Foster Care; Middle Ages; Belgium; Adults; Roman Catholics ER - TY - JOUR T1 - Aphasic and Non-Brain-Damaged Adults' Knowledge of Scripts for Common Situations AN - 58185236; 8906392 AB - The possibility that script knowledge is affected in aphasia was examined in a study that considered whether aphasia affects (1) the ability to discriminate between scripts, (2) judgment of the centrality of events in a script, & (3) sequencing of central events in scripts. Four test scripts & 4 distractor scripts were used as stimuli, along with 20 sentences describing events that might occur in each script (for test scripts) or 5 sentences (for distractor scripts). Ss were aphasic adults & unimpaired adults (N = 12 each). Ss were given a set of 15 event cards for one script, along with 5 foil event cards, & asked to separate the two sets. Ss were given 15 event cards & asked to choose the 8 most central. Finally, a sequencing task was completed in which Ss were asked to place 5 preselected event cards in the most likely order of occurrence. No significant differences were found between aphasics' & normals' performance on discrimination or centrality judgment tasks. Aphasics did more poorly at sequencing; however, most of the differences were attributable to a single script. Results suggest that at least for moderate aphasics, script knowledge remains relatively intact. 3 Tables, 21 References. B. Annesser Murray JF - Brain and Language AU - Armus, Sharon R AU - Brookshire, Robert H AU - Nicholas, Linda E AD - c/o Brookshire-Speech Pathology Section [127A] Veterans Administration Medical Center, Minneapolis MN 55417 Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 518 EP - 528 VL - 36 IS - 3 SN - 0093-934X, 0093-934X KW - aphasic's affected script knowledge possibility KW - aphasic /unimpaired adults KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58185236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Aphasic+and+Non-Brain-Damaged+Adults%27+Knowledge+of+Scripts+for+Common+Situations&rft.au=Armus%2C+Sharon+R%3BBrookshire%2C+Robert+H%3BNicholas%2C+Linda+E&rft.aulast=Armus&rft.aufirst=Sharon&rft.date=1989-04-01&rft.volume=36&rft.issue=3&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1) ER - TY - JOUR T1 - Conflict Ideologies and Their Potential for Change in Adult Residential Care AN - 1761712983; 199001530 AB - Community-based adult residential care receives scant attention in the literature on long-term care, though it is competitive in that arena. It appears that vested medical interest groups, possibly through the utilization of false dichotomies, support the cause of nursing home care at the expense of adult residential care. Conflict ideologies & sociological conflict theory are recommended to combat problems in the adult residential care industry. Radical, feminist, & holistic social workers could contribute to needed changes. Tactics for such change are recommended, along with the development of a social movement headed by a full-time moral crusader. 65 References. HA JF - Adult Residential Care Journal AU - McCoin, John M AD - Veterans Administration Medical Center, Leavenworth KS 66048 Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 52 EP - 65 VL - 3 IS - 1 SN - 0899-1995, 0899-1995 KW - community-based adult residential vs nursing home care, conflict ideologies/theory KW - Elderly KW - Residential Institutions KW - Nursing Homes KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761712983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adult+Residential+Care+Journal&rft.atitle=Conflict+Ideologies+and+Their+Potential+for+Change+in+Adult+Residential+Care&rft.au=McCoin%2C+John+M&rft.aulast=McCoin&rft.aufirst=John&rft.date=1989-04-01&rft.volume=3&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Adult+Residential+Care+Journal&rft.issn=08991995&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Nursing Homes; Residential Institutions ER - TY - JOUR T1 - Transcriptional regulation of proto-oncogene expression by epidermal growth factor, transforming growth factor beta 1, and triiodothyronine in MDA-468 cells. AN - 78868367; 2563727 AB - We have examined the epidermal growth factor (EGF) dependence of the transcription of different proto-oncogenes, using cultured human mammary carcinoma MDA-468 cells and a nuclear run-on transcription assay. We found that the stimulation of MDA-468 cells with EGF regulates moderately and to different extents the transcription of the EGF-receptor(R) and c-erbB-2 proto-oncogenes. In contrast, the transcription of other proto-oncogenes, including c-myc, c-H-ras, and c-fps, was unchanged. Furthermore, we provide evidence that transforming growth factor beta 1 (TGF-beta 1) selectively and to different degrees modulates the EGF-dependent transcription of EGF-R and c-erbB-2 genes. In this study, we also discovered that T3 (triiodothyronine) exerts synergistic control on the action of EGF alone or in association with TGF-beta 1, on EGF-R and c-erbB-2 gene transcription. Moreover, we established that within 6 h after the addition of EGF, cytoplasmic EGF-R mRNA levels are increased several-fold and that this accumulation is enhanced by the presence of TGF-beta 1 and/or T3. The results described here are consistent with the hypothesis that a complex program of cooperative interactions among EGF-, TGF-beta 1-, and T3-generated signals at the transcriptional level may mediate, at least in part, the combined actions of EGF, TGF-beta 1, and T3 in target cells. JF - The Journal of biological chemistry AU - Fernandez-Pol, J A AU - Hamilton, P D AU - Klos, D J AD - Laboratory of Molecular Oncology, Veterans Administration Medical Center, St. Louis, Missouri 63106. Y1 - 1989/03/05/ PY - 1989 DA - 1989 Mar 05 SP - 4151 EP - 4156 VL - 264 IS - 7 SN - 0021-9258, 0021-9258 KW - Proto-Oncogene Proteins KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Epidermal Growth Factor KW - 62229-50-9 KW - Transforming Growth Factors KW - 76057-06-2 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured KW - Receptor, Epidermal Growth Factor -- genetics KW - Humans KW - Drug Synergism KW - Time Factors KW - Triiodothyronine -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Transforming Growth Factors -- pharmacology KW - Epidermal Growth Factor -- pharmacology KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78868367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Transcriptional+regulation+of+proto-oncogene+expression+by+epidermal+growth+factor%2C+transforming+growth+factor+beta+1%2C+and+triiodothyronine+in+MDA-468+cells.&rft.au=Fernandez-Pol%2C+J+A%3BHamilton%2C+P+D%3BKlos%2C+D+J&rft.aulast=Fernandez-Pol&rft.aufirst=J&rft.date=1989-03-05&rft.volume=264&rft.issue=7&rft.spage=4151&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-03 N1 - Date created - 1989-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval. AN - 85251776; pmid-2920190 AB - Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to which the response to the conditioning stimulus diminishes the response to a test stimulus occurring a short time later. Recordings were made at conditioning-testing intervals of 500 msec, 150 msec, and 75 msec to determine subjects' gating of responsiveness to stimuli repeated at various intervals. The schizophrenics had conditioning-testing ratios indicative of poor gating of the auditory P50 wave at the 500-msec and 150-msec intervals, but most patients had good sensory gating at the 75-msec interval. Normal subjects showed good sensory gating at all three intervals. Results suggest that although sensory gating mechanisms responsible for changes in neuronal response at longer intervals are chronically defective in schizophrenics, other gating mechanisms functioning at shorter intervals appear to be intact and function well in most patients. The results may lead to increased specification of the neurobiological basis of sensory abnormalities in schizophrenia. JF - Biological Psychiatry AU - Nagamoto, H T AU - Adler, L E AU - Waldo, M C AU - Freedman, R AD - Denver Veterans Administration Medical Center, CO. PY - 1989 SP - 549 EP - 561 VL - 25 IS - 5 SN - 0006-3223, 0006-3223 KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Adult KW - Evoked Potentials, Auditory KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Time Perception KW - Chronic Disease KW - Male KW - Female KW - Reaction Time KW - Arousal KW - Electroencephalography KW - Schizophrenic Psychology KW - Attention KW - Auditory Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85251776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Sensory+gating+in+schizophrenics+and+normal+controls%3A+effects+of+changing+stimulation+interval.&rft.au=Nagamoto%2C+H+T%3BAdler%2C+L+E%3BWaldo%2C+M+C%3BFreedman%2C+R&rft.aulast=Nagamoto&rft.aufirst=H&rft.date=1989-03-01&rft.volume=25&rft.issue=5&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Repetitive firing properties of medial pontine reticular formation neurones of the rat recorded in vitro. AN - 79241196; 2795489 AB - 1. Intracellularly recorded neurones in nucleus reticularis pontis caudalis of the medial pontine reticular formation (mPRF) in the in vitro slice preparation were analysed for repetitive firing properties in response to intracellularly applied constant-current pulses. 2. Three neuronal classes were defined by this procedure: (1) non-burst neurones, which had only a non-burst firing pattern; (2) low-threshold burst neurones, which had either a low-threshold burst pattern or a non-burst pattern; (3) high-threshold burst neurones, which had either a high-threshold burst pattern or a non-burst pattern. 3. Histological characterization of electrophysiologically identified mPRF neurones with carboxyfluorescein showed no definite morphological difference between the first two classes. There was a trend for low-threshold burst neurones to have larger somata. 4. The low-threshold burst was generated by a slow calcium-dependent low-threshold spike, revealed in the presence of tetrodotoxin. The size of the low-threshold spike and thus the number of fast action potentials in the low-threshold burst was controlled by at least five factors including: activation; inactivation; amplitude of low-threshold conductance available to be activated; delayed outward conductance; and early transient outward conductance. 5. The non-burst pattern examined in both non-burst and low-threshold burst neurones appeared to be controlled primarily by one or more calcium-dependent potassium conductances sensitive to the removal of calcium and tetraethyl-ammonium. In the presence of tetrodotoxin (TTX), the addition of antagonists to calcium-dependent potassium current revealed a slow high-threshold calcium spike which was distinguished from the low-threshold spike by its threshold, lack of inactivation (at potentials negative to -40 mV) and insensitivity to Mg2+. A long-duration after-hyperpolarization (greater than 0.5 s) was not observed in any of these cells. 6. An early transient outward rectification sensitive to 4-aminopyridine and probably mediated by A-current was apparent in low-threshold burst and non-burst neurones and affected both the low-threshold burst and non-burst firing patterns. 7. Alteration of resting membrane potential, such as occurs in vivo during the depolarization associated with desynchronized sleep, may inactivate the low-threshold spike and the transient outward conductance responsible for the distinctive responses observed from more hyperpolarized membrane potentials and produce a more homogeneous non-burst response pattern. Membrane potential effects on intrinsic conductances thus may furnish an important mechanism for changes in mPRF neuronal responsivene JF - The Journal of physiology AU - Gerber, U AU - Greene, R W AU - McCarley, R W AD - Veterans Administration Medical Center, Brockton, MA. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 533 EP - 560 VL - 410 SN - 0022-3751, 0022-3751 KW - Potassium Channels KW - 0 KW - Quaternary Ammonium Compounds KW - Tetrodotoxin KW - 4368-28-9 KW - tetramethylammonium KW - H0W55235FC KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Membrane Potentials KW - Potassium Channels -- physiology KW - Calcium -- pharmacology KW - Action Potentials -- drug effects KW - Tetrodotoxin -- pharmacology KW - Quaternary Ammonium Compounds -- pharmacology KW - Potassium Channels -- drug effects KW - Pons KW - Reticular Formation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79241196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+physiology&rft.atitle=Repetitive+firing+properties+of+medial+pontine+reticular+formation+neurones+of+the+rat+recorded+in+vitro.&rft.au=Gerber%2C+U%3BGreene%2C+R+W%3BMcCarley%2C+R+W&rft.aulast=Gerber&rft.aufirst=U&rft.date=1989-03-01&rft.volume=410&rft.issue=&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+physiology&rft.issn=00223751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-01 N1 - Date created - 1989-11-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1980 Jul 24;286(5771):391-3 [7402320] J Comp Neurol. 1988 Feb 22;268(4):527-45 [3356804] Science. 1980 Dec 5;210(4474):1125-6 [6777871] Brain Res. 1981 Feb 9;206(1):244-50 [6970607] J Physiol. 1980 Nov;308:287-313 [7230018] J Gen Physiol. 1981 Jul;78(1):87-110 [6265594] J Physiol. 1981 Jun;315:549-67 [6273544] Nature. 1982 Apr 22;296(5859):746-9 [6280066] Nature. 1982 Jun 3;297(5865):406-8 [7078650] Pflugers Arch. 1982 May;393(3):248-53 [6285269] Nature. 1982 Sep 16;299(5880):252-4 [6287290] Nature. 1982 Nov 11;300(5888):185-8 [6982421] Rev Physiol Biochem Pharmacol. 1983;97:1-67 [6306751] J Neurophysiol. 1983 Oct;50(4):798-818 [6631464] Brain Res. 1984 Jan 30;292(1):169-75 [6320969] J Physiol. 1984 Apr;349:205-26 [6737292] Nature. 1984 Aug 9-15;310(5977):501-2 [6087159] J Physiol. 1984 Sep;354:319-31 [6434729] Neuroscience. 1984 Sep;13(1):137-56 [6493483] Brain Res. 1984 Nov;320(1):1-63 [6440659] Annu Rev Neurosci. 1985;8:307-37 [3920944] Proc Natl Acad Sci U S A. 1985 May;82(9):3040-4 [2581262] Annu Rev Physiol. 1985;47:17-28 [2581502] Nature. 1985 Aug 1-7;316(6027):440-3 [2410796] Br J Pharmacol. 1985 May;85(1):163-9 [4027463] J Physiol. 1985 Aug;365:59-75 [4040969] J Neurophysiol. 1985 Oct;54(4):782-806 [2999347] Neuroscience. 1985 Dec;16(4):719-37 [2419787] Pflugers Arch. 1986 Apr;406(4):372-9 [2423952] J Physiol. 1986 Mar;372:1-23 [2425081] J Neurophysiol. 1986 Jun;55(6):1268-82 [2426421] J Neurosci Methods. 1986 Jun;16(4):251-63 [2426526] Science. 1986 Nov 7;234(4777):738-40 [3775364] Neuroscience. 1986 Nov;19(3):669-83 [2432443] Science. 1987 Feb 6;235(4789):680-2 [2433765] J Neurophysiol. 1987 Jul;58(1):1-32 [3612221] J Physiol. 1986 Nov;380:127-43 [3612561] J Comp Neurol. 1966 Mar;126(3):311-35 [4957032] C R Seances Soc Biol Fil. 1968 Jul;162(1):119-23 [4302569] J Physiol. 1971 Feb;213(1):21-30 [5575340] J Gen Physiol. 1971 Jul;58(1):36-53 [5564761] J Neurophysiol. 1975 Jul;38(4):751-66 [1159463] J Physiol. 1975 Jul;249(2):211-39 [1177091] J Physiol. 1976 Mar;255(3):737-74 [1083431] J Physiol. 1977 Feb;265(2):465-88 [850203] Annu Rev Physiol. 1979;41:127-40 [373586] J Physiol. 1979 Jan;286:41-60 [439033] J Physiol. 1979 Jun;291:531-44 [480247] J Neurosci Methods. 1979 Dec;1(4):323-5 [544974] J Neurophysiol. 1980 Feb;43(2):409-19 [6247461] J Physiol. 1987 Apr;385:733-59 [2443676] J Physiol. 1987 Aug;389:187-203 [2445972] J Neurophysiol. 1988 Feb;59(2):424-49 [3351569] Annu Rev Neurosci. 1980;3:141-67 [6251744] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute and chronic renal effects of radiocontrast in diabetic rats. Role of anesthesia and risk factors. AN - 79124397; 2753635 AB - The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased 14C-inulin clearance (Cin) in both DM and C rats (P less than .001 vs. conscious values), there was no impairment of Cin in either group after administration of CM. In chronic studies, creatinine clearance (Ccr) was followed for 3-4 days after CM administration. Four protocols to assess risk factors in DM and C were used: adult rats with normal hydration (2A); old dehydrated rats with DM of long duration (2B); rats with prior decreased Ccr (remnant kidney, 2C); and DM rats treated with insulin (2D). No clear-cut nephrotoxicity was apparent in these studies, except that proteinuria increased with CM in Study 2C. A greater severity of renal dysfunction, renal disease, or the association of multiple risk factors may be necessary to induce CM-related nephrotoxicity in the experimental animal. The rat, diabetic or not, may have an inherent resistance to CM-induced renal injury. JF - Investigative radiology AU - Vaamonde, C A AU - Bier, R T AU - Papendick, R AU - Alpert, H AU - Gouvea, W AU - Owens, B AU - Pardo, V AD - Medical Service, Veterans Administration Medical Center, Miami, Florida 33125. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 206 EP - 218 VL - 24 IS - 3 SN - 0020-9996, 0020-9996 KW - Diatrizoate Meglumine KW - 3X9MR4N98U KW - Inulin KW - 9005-80-5 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Aging -- physiology KW - Kidney Function Tests KW - Animals KW - Dehydration -- complications KW - Anesthesia KW - Risk Factors KW - Glomerular Filtration Rate -- drug effects KW - Urography KW - Dehydration -- physiopathology KW - Female KW - Diabetes Mellitus, Experimental -- diagnostic imaging KW - Kidney -- drug effects KW - Diabetes Mellitus, Experimental -- complications KW - Diatrizoate Meglumine -- toxicity KW - Kidney -- physiopathology KW - Diabetes Mellitus, Experimental -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79124397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Acute+and+chronic+renal+effects+of+radiocontrast+in+diabetic+rats.+Role+of+anesthesia+and+risk+factors.&rft.au=Vaamonde%2C+C+A%3BBier%2C+R+T%3BPapendick%2C+R%3BAlpert%2C+H%3BGouvea%2C+W%3BOwens%2C+B%3BPardo%2C+V&rft.aulast=Vaamonde&rft.aufirst=C&rft.date=1989-03-01&rft.volume=24&rft.issue=3&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-05 N1 - Date created - 1989-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholecystokinin and vasoactive intestinal peptide in brain and gut of the hypothyroid neonatal rat. AN - 79078940; 2744718 AB - The rat has been a useful model for studying neuronal and metabolic abnormalities associated with fetal and neonatal hypothyroidism produced by treatment of the mother with antithyroid medication. The neonates are then maintained on this medication via the mother's milk until weaning and subsequently through the drinking water. We have determined the concentrations and contents of immunoreactive cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in the brain and gut of groups of rats exposed to antithyroid medication from day 16 of gestation. The neonates were sacrificed at 2, 4, 8 and 12 weeks. Compared to controls total body weight was greatly reduced in methimazole (MMI)-treated rats, all of whom were hypothyroid as evidenced by marked reduction of T4 and increase in TSH. Discontinuation of MMI-treatment after 8 weeks resulted in normalization of T4 and TSH and a dramatic weight gain but at 12 weeks the brain weights of the MMI-treated rats were reduced by 17% and the brain contents, of CCK and VIP were similarly reduced. Tissue weights throughout the gut were 1/2 or less than those of control rats. Since VIP but not CCK concentrations in the gut of MMI-treated animals were significantly greater than those of the control animals, it would appear that there was greater loss of mucosal tissue with its endocrine content of CCK than of neuronal tissue with its greater content of VIP.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme AU - Zheng, B AU - Eng, J AU - Yalow, R S AD - Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, New York. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 127 EP - 131 VL - 21 IS - 3 SN - 0018-5043, 0018-5043 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Methimazole KW - 554Z48XN5E KW - Cholecystokinin KW - 9011-97-6 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Aging -- metabolism KW - Body Weight -- drug effects KW - Radioimmunoassay KW - Methimazole -- pharmacology KW - Female KW - Pregnancy KW - Organ Size -- drug effects KW - Digestive System -- drug effects KW - Vasoactive Intestinal Peptide -- metabolism KW - Hypothyroidism -- metabolism KW - Brain Chemistry -- drug effects KW - Digestive System -- metabolism KW - Hypothyroidism -- chemically induced KW - Animals, Newborn -- metabolism KW - Cholecystokinin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79078940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.atitle=Cholecystokinin+and+vasoactive+intestinal+peptide+in+brain+and+gut+of+the+hypothyroid+neonatal+rat.&rft.au=Zheng%2C+B%3BEng%2C+J%3BYalow%2C+R+S&rft.aulast=Zheng&rft.aufirst=B&rft.date=1989-03-01&rft.volume=21&rft.issue=3&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.issn=00185043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Responsiveness of the hamster pancreatic cancer to treatment with microcapsules of D-Trp-6-LH-RH and somatostatin analog RC-160. Histological evidence of improvement. AN - 79014587; 2566638 AB - The effect of treatment with D-Trp-6-LH-RH, an agonist of luteinizing hormone-releasing hormone (LHRH), and somatostatin analog RC-160 was studied in male Syrian hamsters with N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinoma. The peptides were administered periodically in long-acting microcapsule formulations designed to release controlled doses and maintain continuous blood levels of these analogs. The treatment lasted 60 d. Eighteen wk after administration of BOP, 80% of the animals developed ductal pancreatic adenocarcinomas, typically in multinodular form. Treatment with D-Trp-6-LH-RH resulted in a significant decrease in the tumorous pancreatic weight, and, in 35% of the specimens, changes indicative of histological regression were seen. Similarly, regressive alterations in the tumorous epithelium could be observed in 28% of the tumors in the RC-160 treated group. This regression was not accompanied by accumulation of lymphoid cells and only the epithelial components of the tumors were involved. These data indicate that the analogs D-Trp-6-LH-RH and RC-160 exert antitumoral effects on the experimentally-induced pancreatic cancer. It is unlikely that immunological mechanisms are involved in this response. These inhibitory effects on tumor growth could be mediated by creating a state of sex hormone deprivation of D-Trp-6-LH-RH and by inhibition of the release and/or action of gastrointestinal hormones and growth factors by the somatostatin analog RC-160. JF - International journal of pancreatology : official journal of the International Association of Pancreatology AU - Zalatnai, A AU - Schally, A V AD - Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 149 EP - 160 VL - 4 IS - 2 SN - 0169-4197, 0169-4197 KW - Antineoplastic Agents KW - 0 KW - Capsules KW - Nitrosamines KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Index Medicus KW - Pancreas -- pathology KW - Animals KW - Mesocricetus KW - Epithelium -- pathology KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Cricetinae KW - Pancreatic Neoplasms -- pathology KW - Somatostatin -- therapeutic use KW - Pancreatic Neoplasms -- chemically induced KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Somatostatin -- analogs & derivatives KW - Pancreatic Neoplasms -- drug therapy KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79014587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.atitle=Responsiveness+of+the+hamster+pancreatic+cancer+to+treatment+with+microcapsules+of+D-Trp-6-LH-RH+and+somatostatin+analog+RC-160.+Histological+evidence+of+improvement.&rft.au=Zalatnai%2C+A%3BSchally%2C+A+V&rft.aulast=Zalatnai&rft.aufirst=A&rft.date=1989-03-01&rft.volume=4&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.issn=01694197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-12 N1 - Date created - 1989-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative effects of disulfiram and diethyldithiocarbamate on cadmium distribution in mice. AN - 78998746; 2543044 AB - It has been reported that disulfiram (DSF) and diethyldithiocarbamate (DDTC) have similar actions on cadmium (Cd) distribution in maternal and fetal organs when given to pregnant mice prior to and again immediately after iv administration of Cd (Arch. Toxicol. 55, 161-167, 1984). We have now examined Cd distribution in mice in which virtually all of the Cd was bound to metallothionein (MT) in an attempt to simulate more closely the condition of low level, chronic Cd exposure. When DSF was incorporated into food and ingested by mice over a 4-hr period on each of four days, hepatic and pulmonary Cd levels were reduced significantly. When given ip at 500 mg/kg, DDTC lowered hepatic, renal, splenic, and pancreatic Cd levels, but increased Cd concentrations in brain, testes, heart, and lungs. When DSF was given at 500 mg/kg ip, it lowered hepatic, splenic, testicular, and pancreatic Cd levels, but increased Cd concentrations in heart and brain. In contrast to DDTC, DSF had no effect on pulmonary or renal Cd. When given as a bolus dose po for five days at 1.0 mmole/kg, DDTC lowered renal, splenic, testicular, and pancreatic Cd levels, but increased Cd concentrations in brain and heart. There was no effect on hepatic or pulmonary Cd. When given at the same dose po, DSF did not alter the Cd concentration of any organ assessed. We suggest that studies of interactions of various xenobiotics with Cd in vivo should be done with an animal model which simulates chronic Cd exposure rather than acute Cd intoxication. JF - Research communications in chemical pathology and pharmacology AU - Gale, G R AU - Smith, A B AU - Atkins, L M AD - Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 395 EP - 410 VL - 63 IS - 3 SN - 0034-5164, 0034-5164 KW - Cadmium Radioisotopes KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Ditiocarb KW - 99Z2744345 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Tissue Distribution KW - Male KW - Mice, Inbred DBA KW - Ditiocarb -- pharmacology KW - Disulfiram -- pharmacology KW - Cadmium -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78998746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Comparative+effects+of+disulfiram+and+diethyldithiocarbamate+on+cadmium+distribution+in+mice.&rft.au=Gale%2C+G+R%3BSmith%2C+A+B%3BAtkins%2C+L+M&rft.aulast=Gale&rft.aufirst=G&rft.date=1989-03-01&rft.volume=63&rft.issue=3&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-29 N1 - Date created - 1989-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Source of ethane in expirate of rats ventilated with 100% oxygen. AN - 78936470; 2708248 AB - Ethane in alveolar expirate may have its source in organs other than the lung and be transported to the lung for elimination. We determined ethane production rates in rats (group I) ventilated with hydrocarbon-free air (HFA) before and after exsanguination. To determine whether the lung is the source of increased ethane production during exposure to 100% O2, we measured ethane in the expirate of nine exsanguinated, Sprague-Dawley rats (group II) mechanically ventilated with HFA and then with 100% O2. In all nine animals, ethane elimination rates on 100% O2 increased compared with HFA values. In five of the nine rats, HFA ventilation was reinstated after O2 (group III). In all five, ethane elimination fell with HFA ventilation compared with the value on 100%. Six rats with circulation intact were ventilated with HFA and then 100% O2 (group IV). Ethane production rate for group IV animals breathing HFA was not significantly different from the exsanguinated animals in group II while ventilated with HFA. The mean increase in ethane production for the group II animals was not significantly different from the group IV animals. Lung slices from four other rats (group V) were incubated in saline at 37 degrees C with FeCl2 (10 mg) added to enhance free radical formation. Paired lung samples from the same rat were incubated with either HFA or 100% O2. Headspace gas was analyzed chromatographically for ethane at 120 min. Mean ethane in the O2 samples was higher than for HFA. Rat lung tissue is the main source of increased ethane production during 100% O2 exposure. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Habib, M P AU - Katz, M A AD - Benjamin W. Zweifach Microcirculation Laboratories, Tucson Veterans Administration Medical Center, Arizona. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 1268 EP - 1272 VL - 66 IS - 3 SN - 8750-7587, 8750-7587 KW - Ethane KW - L99N5N533T KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Ethane -- analysis KW - Oxygen -- toxicity KW - Respiration -- drug effects KW - Ethane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78936470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Source+of+ethane+in+expirate+of+rats+ventilated+with+100%25+oxygen.&rft.au=Habib%2C+M+P%3BKatz%2C+M+A&rft.aulast=Habib&rft.aufirst=M&rft.date=1989-03-01&rft.volume=66&rft.issue=3&rft.spage=1268&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential diagnosis of psychosis. A brief guide for the primary care physician. AN - 78931996; 2928277 AB - By keeping in mind that not a psychosis is schizophrenia, the primary care physician can often avoid misdiagnosis in behaviorally disturbed patients. Abnormal behavior may result from mood disorders, drug-induced psychosis and other organic disorders, personality disorders, delusional disorders, autism, or mental retardation. A long-term history is essential for correct diagnosis and treatment. JF - Postgraduate medicine AU - Citrome, L AD - Psychiatry Service, Franklin Delano Roosevelt Veterans Administration Hospital, Montrose 10548. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 273 EP - 4, 279-80 VL - 85 IS - 4 SN - 0032-5481, 0032-5481 KW - Abridged Index Medicus KW - Index Medicus KW - Neurocognitive Disorders -- diagnosis KW - Diagnosis, Differential KW - Psychoses, Substance-Induced -- diagnosis KW - Humans KW - Schizophrenia -- diagnosis KW - Primary Health Care KW - Affective Disorders, Psychotic -- diagnosis KW - Psychotic Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78931996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Differential+diagnosis+of+psychosis.+A+brief+guide+for+the+primary+care+physician.&rft.au=Citrome%2C+L&rft.aulast=Citrome&rft.aufirst=L&rft.date=1989-03-01&rft.volume=85&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-24 N1 - Date created - 1989-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential effects of prostaglandin E2 on contractions of airway smooth muscle. AN - 78924534; 2468642 AB - In an in vitro muscle bath, the active tension generated by strips of canine tracheal smooth muscle responding to cumulative additions of either histamine (10(-8) to 10(-3) M) or acetylcholine (10(-9) to 10(-3) M) was measured in the absence and presence of prostaglandin E2 (PGE2) (10(-6) to 10(-5) M). When contractile responses of equal magnitude were compared, the contractions elicited by acetylcholine were resistant to the inhibitory effects of PGE2, relative to comparable contractions elicited by histamine. To assess the role of adenylate cyclase in determining the different responses to histamine and acetylcholine in the presence of PGE2, we assayed adenylate cyclase activity in membranes prepared from canine tracheal smooth muscle and found that acetylcholine, but not histamine, decreased PGE2-stimulated adenylate cyclase activity by 48 +/- 2% (mean +/- SE; n = 5). However, in other experiments, we found that even large pharmacological increases in tissue adenosine 3',5'-cyclic monophosphate (cAMP) content only partially inhibited muscarinic tone. Also, exogenously applied analogues of cyclic AMP inhibited contractions induced by histamine more effectively than comparable contractions induced by acetylcholine. We concluded that acetylcholine decreased adenylate cyclase activity in membranes prepared from canine tracheal smooth muscle and that this effect may have contributed to, but did not completely account for, the relative resistance of muscarinic contractions to the inhibitory effects of PGE2. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Madison, J M AU - Jones, C A AU - Sankary, R M AU - Brown, J K AD - Medical Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 1397 EP - 1407 VL - 66 IS - 3 SN - 8750-7587, 8750-7587 KW - Methacholine Compounds KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - Dimethylphenylpiperazinium Iodide KW - 54-77-3 KW - Atropine KW - 7C0697DR9I KW - Histamine KW - 820484N8I3 KW - Carbachol KW - 8Y164V895Y KW - Propranolol KW - 9Y8NXQ24VQ KW - Dinoprostone KW - K7Q1JQR04M KW - Acetylcholine KW - N9YNS0M02X KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Index Medicus KW - Animals KW - Propranolol -- pharmacology KW - Methacholine Compounds -- pharmacology KW - Acetylcholine -- pharmacology KW - Histamine -- pharmacology KW - Dimethylphenylpiperazinium Iodide -- pharmacology KW - Kinetics KW - In Vitro Techniques KW - Dogs KW - Tetrodotoxin -- pharmacology KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Atropine -- pharmacology KW - Carbachol -- pharmacology KW - Muscle, Smooth -- physiology KW - Dinoprostone -- pharmacology KW - Muscle Contraction -- drug effects KW - Trachea -- drug effects KW - Muscle, Smooth -- drug effects KW - Trachea -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78924534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Differential+effects+of+prostaglandin+E2+on+contractions+of+airway+smooth+muscle.&rft.au=Madison%2C+J+M%3BJones%2C+C+A%3BSankary%2C+R+M%3BBrown%2C+J+K&rft.aulast=Madison&rft.aufirst=J&rft.date=1989-03-01&rft.volume=66&rft.issue=3&rft.spage=1397&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The neurology of memory: quantitative assessment of retrograde amnesia in two groups of amnesic patients. AN - 78920855; 2926483 AB - The phenomenon of retrograde amnesia has important implications for understanding normal memory as well as its neural organization. Using 6 tests of remote memory, we evaluated the extent and severity of retrograde amnesia in 2 groups of amnesic patients--7 patients with alcoholic Korsakoff's syndrome and 5 other patients with amnesia (anoxia or ischemia, N = 3; thalamic infarction, N = 1; unknown etiology, N = 1). Although there were individual differences, Experiment 1 showed that the severity and extent of retrograde amnesia was similar for the 2 groups. Retrograde amnesia was temporally graded across a period of about 15 years and was not detectable in more remote time periods. In Experiment 2, repeated testing during a 3 year period showed that amnesic patients and control subjects were similarly consistent in their responses. Amnesic patients did not catch up to control subjects by eventually accumulating as many correct answers as the control subjects. In Experiment 3, amnesic patients performed normally on a test of very difficult general information questions, which were based on material likely to have been learned long ago. In all 3 experiments, the 2 groups of amnesic patients performed similarly. The results support the following conclusions: (1) Extensive, temporally graded retrograde amnesia, which has been observed frequently in patients with Korsakoff's syndrome, occurs readily in other amnesic patients as well, even when their memory impairment appears well circumscribed; (2) patients with presumed damage to either the medial temporal or the diencephalic brain structures linked to memory functions can produce a similar kind of retrograde amnesia; (3) the impairment reflects a loss of usable knowledge, not simply difficulty accessing an intact memory store that can then be overcome given sufficient retrieval opportunities; (4) very remote memory, at least for factual information, can be intact in amnesia; (5) the structures damaged in amnesia support memory storage, retrieval, or both during a lengthy period of reorganization, after which representations in memory can become independent of these structures. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Squire, L R AU - Haist, F AU - Shimamura, A P AD - Veterans Administration Medical Center, University of California, San Diego, La Jolla 92093. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 828 EP - 839 VL - 9 IS - 3 SN - 0270-6474, 0270-6474 KW - Index Medicus KW - Reference Values KW - Mental Recall -- physiology KW - Pattern Recognition, Visual KW - Humans KW - Alcohol Amnestic Disorder -- psychology KW - Middle Aged KW - Neuropsychological Tests KW - Face KW - Alcoholism -- psychology KW - Male KW - Female KW - Amnesia -- physiopathology KW - Memory -- physiology KW - Amnesia -- psychology KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78920855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=The+neurology+of+memory%3A+quantitative+assessment+of+retrograde+amnesia+in+two+groups+of+amnesic+patients.&rft.au=Squire%2C+L+R%3BHaist%2C+F%3BShimamura%2C+A+P&rft.aulast=Squire&rft.aufirst=L&rft.date=1989-03-01&rft.volume=9&rft.issue=3&rft.spage=828&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-05 N1 - Date created - 1989-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sister chromatid exchanges in adult epilepsy patients on valproate monotherapy. AN - 78920824; 2495938 AB - Sister chromatid exchanges (SCE) were studied in peripheral lymphocyte cultures of 13 adult male patients with epilepsy treated chronically with valproate (VPA) and in their matched controls. No statistically significant differences in SCE level were found between the patient and control groups, indicating a lack of mutagenic potential of VPA within the therapeutic dose range. JF - Epilepsy research AU - Schaumann, B A AU - Winge, V B AU - Garry, V F AD - Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417. PY - 1989 SP - 182 EP - 184 VL - 3 IS - 2 SN - 0920-1211, 0920-1211 KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Epilepsy -- genetics KW - Sister Chromatid Exchange -- drug effects KW - Epilepsy -- drug therapy KW - Valproic Acid -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78920824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=Sister+chromatid+exchanges+in+adult+epilepsy+patients+on+valproate+monotherapy.&rft.au=Schaumann%2C+B+A%3BWinge%2C+V+B%3BGarry%2C+V+F&rft.aulast=Schaumann&rft.aufirst=B&rft.date=1989-03-01&rft.volume=3&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-01 N1 - Date created - 1989-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of platelet activating factor in endotoxemic acute renal failure in the male rat. AN - 78911093; 2538527 AB - We have developed a model of endotoxemic acute renal failure in the anesthetized male rat in which acute endotoxin infusion induces renal vasoconstriction and decreased glomerular filtration rate (GFR) in the absence of systemic hypotension. Because increased levels of platelet activating factor (PAF) have been observed in experimental models of endotoxemia, we pretreated rats with PAF receptor antagonist BN 52021 or SRI 63-675 before administering endotoxin. Compared with treatment with vehicle, treatment with BN 52021 led to significant preservation of RBF, GFR, and urine flow rate. Pretreatment with SRI 63-675 resulted in significant improvement in RBF while completely preventing the fall in GFR and urine flow rate. Intrarenal artery infusion of exogenous PAF (30 ng/kg/min) resulted in renal vasoconstriction, decreased GFR, and oliguria. These effects were also prevented by pretreatment with SRI 63-675. Thus, the adverse renal hemodynamic effects of endotoxemia were blunted or prevented by pretreatment with PAF receptor antagonists. We conclude that endogenously produced PAF is an important mediator of endotoxemic acute renal failure. JF - The Journal of laboratory and clinical medicine AU - Tolins, J P AU - Vercellotti, G M AU - Wilkowske, M AU - Ha, B AU - Jacob, H S AU - Raij, L AD - Department of Medicine, Veterans Administration, Minneapolis, MN 55417. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 316 EP - 324 VL - 113 IS - 3 SN - 0022-2143, 0022-2143 KW - Diterpenes KW - 0 KW - Ginkgolides KW - Lactones KW - Lipopolysaccharides KW - Platelet Activating Factor KW - Platelet Membrane Glycoproteins KW - Quinolines KW - Receptors, Cell Surface KW - Receptors, G-Protein-Coupled KW - platelet activating factor receptor KW - SRI 63-675 KW - 109516-82-7 KW - ginkgolide B KW - DF149B9460 KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Renal Circulation -- drug effects KW - Kidney -- pathology KW - Glomerular Filtration Rate -- drug effects KW - Indomethacin -- pharmacology KW - Lactones -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Quinolines -- pharmacology KW - Blood Pressure -- drug effects KW - Receptors, Cell Surface -- physiology KW - Male KW - Platelet Activating Factor -- physiology KW - Acute Kidney Injury -- physiopathology KW - Lipopolysaccharides -- toxicity KW - Acute Kidney Injury -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78911093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Role+of+platelet+activating+factor+in+endotoxemic+acute+renal+failure+in+the+male+rat.&rft.au=Tolins%2C+J+P%3BVercellotti%2C+G+M%3BWilkowske%2C+M%3BHa%2C+B%3BJacob%2C+H+S%3BRaij%2C+L&rft.aulast=Tolins&rft.aufirst=J&rft.date=1989-03-01&rft.volume=113&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-24 N1 - Date created - 1989-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanism of neuropeptide Y inhibition of vasopressin action in rat cortical collecting tubule. AN - 78899366; 2538078 AB - Neuropeptide Y (NPY) is a unique 36-amino acid peptide found in high concentrations in brain and peripheral neurons. Although NPY is present in kidney tissue, its role in regulation of renal function has not been delineated. We found that NPY significantly decreases arginine vasopressin (AVP) but not adenosine 3',5'-cyclic monophosphate (cAMP)-stimulated hydraulic conductivity (Lp) in perfused rat cortical collecting tubules (CCT). Either alpha 2-adrenergic receptor blockade (yohimbine) or occupancy (clonidine) prevent NPY inhibition of AVP-stimulated Lp. By contrast, alpha 1-adrenergic receptor blockade with prazosin did not alter NPY inhibition of AVP action. Pretreatment of CCT with pertussis toxin also abolishes NPY inhibition of AVP-stimulated Lp. These data suggest that NPY acts via an alpha 2-adrenergic receptor coupled to a pertussis toxin-sensitive protein to inhibit AVP-stimulated cAMP formation and Lp in the rat CCT. JF - The American journal of physiology AU - Dillingham, M A AU - Anderson, R J AD - Medical Service, Denver Veterans Administration Hospital, Colorado 80220. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - F408 EP - F413 VL - 256 IS - 3 Pt 2 SN - 0002-9513, 0002-9513 KW - Neuropeptide Y KW - 0 KW - Virulence Factors, Bordetella KW - Arginine Vasopressin KW - 113-79-1 KW - Yohimbine KW - 2Y49VWD90Q KW - Cyclic AMP KW - E0399OZS9N KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Clonidine KW - MN3L5RMN02 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Virulence Factors, Bordetella -- pharmacology KW - Animals KW - Drug Interactions KW - Yohimbine -- pharmacology KW - Kinetics KW - Prazosin -- pharmacology KW - In Vitro Techniques KW - Cyclic AMP -- pharmacology KW - Clonidine -- pharmacology KW - Arginine Vasopressin -- pharmacology KW - Arginine Vasopressin -- antagonists & inhibitors KW - Kidney Cortex -- physiology KW - Kidney Cortex -- drug effects KW - Kidney Tubules, Collecting -- drug effects KW - Neuropeptide Y -- pharmacology KW - Kidney Tubules, Collecting -- physiology KW - Kidney Tubules -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78899366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Mechanism+of+neuropeptide+Y+inhibition+of+vasopressin+action+in+rat+cortical+collecting+tubule.&rft.au=Dillingham%2C+M+A%3BAnderson%2C+R+J&rft.aulast=Dillingham&rft.aufirst=M&rft.date=1989-03-01&rft.volume=256&rft.issue=3+Pt+2&rft.spage=F408&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-12 N1 - Date created - 1989-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats. AN - 78899017; 2493691 AB - The effects of subarachnoid injection of blood on blood-brain barrier permeability to albumin was assessed in a rat model. Subarachnoid injection of blood caused a significant sixfold increase in Evans blue extravasation, whereas sham operation or NaCl injection had no effect. In addition, subarachnoid injections of arachidonic acid or FeCl2 increased blood-brain barrier permeability to Evans blue 16- and 10-fold, respectively. The capillary permeability after subarachnoid injection of blood was normalized by pretreatment with a novel 21-aminosteroid, U-74006F, that has antioxidant and antilipolytic activity. Pretreatment with U-74006F also reduced the vascular leakage induced by subarachnoid injection of arachidonic acid or FeCl2 by 50% and 45%, respectively. We conclude that damage to membrane lipids by peroxidative and/or lipolytic processes is involved in the subarachnoid hemorrhage-induced blood-brain barrier opening and that U-74006F protects the blood-brain barrier against the effects of subarachnoid hemorrhage by preventing or limiting these pathologic membrane lipid changes. JF - Stroke AU - Zuccarello, M AU - Anderson, D K AD - Veterans Administration Medical Center, Cincinnati, OH 45220. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 367 EP - 371 VL - 20 IS - 3 SN - 0039-2499, 0039-2499 KW - Arachidonic Acids KW - 0 KW - Ferrous Compounds KW - Pregnatrienes KW - Serum Albumin KW - Arachidonic Acid KW - 27YG812J1I KW - Evans Blue KW - 45PG892GO1 KW - ferrous chloride KW - S3Y25PHP1W KW - tirilazad KW - YD064E883I KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Serum Albumin -- metabolism KW - Animals KW - Extravasation of Diagnostic and Therapeutic Materials -- metabolism KW - Ferrous Compounds -- pharmacology KW - Capillary Permeability -- drug effects KW - Brain -- metabolism KW - Male KW - Arachidonic Acids -- pharmacology KW - Blood-Brain Barrier -- drug effects KW - Subarachnoid Hemorrhage -- chemically induced KW - Subarachnoid Hemorrhage -- physiopathology KW - Pregnatrienes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78899017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Protective+effect+of+a+21-aminosteroid+on+the+blood-brain+barrier+following+subarachnoid+hemorrhage+in+rats.&rft.au=Zuccarello%2C+M%3BAnderson%2C+D+K&rft.aulast=Zuccarello&rft.aufirst=M&rft.date=1989-03-01&rft.volume=20&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-20 N1 - Date created - 1989-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acting angiotensin-converting enzyme inhibitor, in patients with chronic congestive heart failure. AN - 78887023; 2537699 AB - Benazepril hydrochloride is a nonsulfhydryl, long-acting angiotensin-converting enzyme inhibitor that is orally effective. This study was designed to determine the acute hemodynamic effects of this agent in patients with chronic congestive heart failure. Twenty-six patients with New York Heart Association class III or IV congestive heart failure and left ventricular ejection fractions less than 35%, cardiac indexes less than 2.1 L/min/m2, and pulmonary artery wedge pressures greater than 12 mm Hg were given 2 or 5 mg benazepril hydrochloride. All does produced significant (p less than 0.05) increases in cardiac output (26.7% to 31.6% above control) and heart rate (5.4% to 11.2% above control) and decreases in systemic (27.1% to 32.0% below control) and pulmonary (34.8% to 55.5% below control) vascular resistances, mean pulmonary (25.3% to 30.3% below control) and systemic (13.4% to 18.5% below control) arterial pressures, and pulmonary artery wedge pressure (46.9% to 51.1% below control). Twenty-four hours after an initial dose, systemic vascular resistance and pulmonary artery wedge pressures remained below control levels. Angiotensin-converting enzyme activity fell by 67.8% +/- 6.4%, with a 15.8% +/- 7.6% decline in aldosterone levels. Thus benazepril hydrochloride is an effective angiotensin-converting enzyme inhibitor that produces hemodynamic effects that persist for 24 hours after a single oral dose. JF - Clinical pharmacology and therapeutics AU - Insel, J AU - Mirvis, D M AU - Boland, M J AU - Cinquegrani, M P AU - Shanes, J AU - Rubin, S A AU - Whalen, J J AD - Veterans Administration Medical Center, Memphis, TN. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 312 EP - 320 VL - 45 IS - 3 SN - 0009-9236, 0009-9236 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Benzazepines KW - Aldosterone KW - 4964P6T9RB KW - Enalapril KW - 69PN84IO1A KW - Captopril KW - 9G64RSX1XD KW - Peptidyl-Dipeptidase A KW - EC 3.4.15.1 KW - Renin KW - EC 3.4.23.15 KW - benazepril KW - UDM7Q7QWP8 KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Multicenter Studies as Topic KW - Humans KW - Aged KW - Captopril -- pharmacology KW - Renin -- blood KW - Peptidyl-Dipeptidase A -- blood KW - Adult KW - Chronic Disease KW - Middle Aged KW - Time Factors KW - Enalapril -- pharmacology KW - Aldosterone -- blood KW - Female KW - Male KW - Heart Failure -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Benzazepines -- administration & dosage KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Benzazepines -- adverse effects KW - Benzazepines -- therapeutic use KW - Angiotensin-Converting Enzyme Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78887023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=A+multicenter+study+of+the+safety+and+efficacy+of+benazepril+hydrochloride%2C+a+long-acting+angiotensin-converting+enzyme+inhibitor%2C+in+patients+with+chronic+congestive+heart+failure.&rft.au=Insel%2C+J%3BMirvis%2C+D+M%3BBoland%2C+M+J%3BCinquegrani%2C+M+P%3BShanes%2C+J%3BRubin%2C+S+A%3BWhalen%2C+J+J&rft.aulast=Insel&rft.aufirst=J&rft.date=1989-03-01&rft.volume=45&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemical testing in patients with alcoholic liver disease. AN - 78886933; 2922622 AB - We evaluated physicians' laboratory utilization patterns for hospitalized patients with alcoholic liver disease and examined the relationship between the frequency of test ordering and certain variables in clinical outcome. During the study, 185 patients with alcoholic liver disease were hospitalized 378 times at the VA Medical Center, Long Beach, California. Physicians ordered liver panels (including serum albumin, alkaline phosphatase, total bilirubin, lactic dehydrogenase, glutamic pyruvate transaminase, and glutamic oxaloacetic transaminase) an average of 7.4 times per hospitalization. Increased biochemical testing did not decrease length of stay or improve clinical outcomes such as development of complications or survival of hospitalization. Since the treatment of alcoholic liver disease is largely supportive and not dependent upon frequent biochemical testing, we recommend that these tests be ordered only when patients are admitted to or discharged from the hospital, and when there has been a clinical change. JF - Southern medical journal AU - Hubbell, F A AU - Webb, D W AU - Ofstein, M R AU - Goldberg, R S AU - Rucker, L AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, Calif. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 318 EP - 320 VL - 82 IS - 3 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Evaluation Studies as Topic KW - Hospitalization KW - Humans KW - Retrospective Studies KW - Prognosis KW - Middle Aged KW - Male KW - Female KW - Practice Patterns, Physicians' KW - Diagnostic Tests, Routine KW - Liver Diseases, Alcoholic -- mortality KW - Liver Diseases, Alcoholic -- complications KW - Liver Diseases, Alcoholic -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78886933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Biochemical+testing+in+patients+with+alcoholic+liver+disease.&rft.au=Hubbell%2C+F+A%3BWebb%2C+D+W%3BOfstein%2C+M+R%3BGoldberg%2C+R+S%3BRucker%2C+L&rft.aulast=Hubbell&rft.aufirst=F&rft.date=1989-03-01&rft.volume=82&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Urea cycle enzyme activities are normal and inducible by a high-protein diet in CCl4 cirrhosis of rats. AN - 78884965; 2920993 AB - We produced moderately severe, inactive micronodular cirrhosis in rats using CCl4 and measured the urea cycle enzyme activities in liver after feeding a 15% casein diet for 1 week and again after a 60% casein diet for 1 week. There was no deficiency of any of the five urea cycle enzymes in cirrhotic livers of rats pair-fed the 15% casein diet. Argininosuccinate synthetase and carbamyl phosphate synthetase activities were lower than in non-pair-fed controls by some baselines. All five enzymes in cirrhotic livers were induced 1.5- to 3-fold by the high-protein diet expressed as units per 100 gm of rat. The level of carbamyl phosphate synthetase activity was lower in the livers of rats pair-fed the 60% casein diet than in control livers based on wet weight, collagen-free protein and DNA, but the activities were equal expressed as units per 100 gm of rat. This example of CCl4-induced cirrhosis in the rat does not serve as a good model for human cirrhosis, in which the urea cycle enzymes are reported to be decreased in activity. JF - Hepatology (Baltimore, Md.) AU - Snodgrass, P J AD - Veterans Administration Medical Center, Indianapolis, Indiana 46202. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 373 EP - 379 VL - 9 IS - 3 SN - 0270-9139, 0270-9139 KW - Dietary Proteins KW - 0 KW - Urea KW - 8W8T17847W KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Male KW - Urea -- metabolism KW - Liver Cirrhosis, Experimental -- chemically induced KW - Dietary Proteins -- administration & dosage KW - Liver Cirrhosis, Experimental -- metabolism KW - Liver Cirrhosis, Experimental -- enzymology KW - Dietary Proteins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78884965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Urea+cycle+enzyme+activities+are+normal+and+inducible+by+a+high-protein+diet+in+CCl4+cirrhosis+of+rats.&rft.au=Snodgrass%2C+P+J&rft.aulast=Snodgrass&rft.aufirst=P&rft.date=1989-03-01&rft.volume=9&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-12 N1 - Date created - 1989-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of an influenza A outbreak in a teaching nursing home. Effectiveness of a protocol for prevention and control. AN - 78877324; 2918190 AB - The safety and efficacy of current ACIP guidelines for the prevention and control of influenza in nursing home populations are uncertain. An outbreak of influenza A/Sichuan (H3N2) in a teaching nursing home during 1988 gave us the opportunity to evaluate the effectiveness of an influenza vaccination and amantadine prophylaxis protocol. Over 13 days, 12 of 60 residents developed influenza. Prior influenza vaccination had been given to 94% of the residents. Protection from infection occurred in those tested who had antibody levels greater than or equal to 1:16 to the A/Leningrad (H3N2) antigen contained in the standard 1987-88 trivalent vaccine. However, five of 17 vaccinated residents who were tested had antibody levels less than or equal to 1:16 at the start of the outbreak. Amantadine (less than or equal to 100 mg/day) was given to all but one resident starting on the third day of the outbreak, and to employees starting on the sixth day of the outbreaks. Seven residents developed illness after the start of amantadine, although amantadine appeared to ameliorate their symptoms. Although amantadine was generally well tolerated by residents, employees receiving amantadine identified a high incidence of side effects and only 44% of employees took at least 70% of the prescribed amantadine. In our opinion, early detection and protocol-directed intervention probably abated a more severe influenza outbreak. Therefore we support existing recommendations that formal nursing home policies be established to ensure that residents and employees receive annual influenza vaccine and that chemoprophylaxis be used when outbreaks of influenza A are suspected. JF - Journal of the American Geriatrics Society AU - Peters, N L AU - Oboler, S AU - Hair, C AU - Laxson, L AU - Kost, J AU - Meiklejohn, G AD - Nursing Home Care Unit, Denver Veterans Administration Medical Center, CO 80220. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 210 EP - 218 VL - 37 IS - 3 SN - 0002-8614, 0002-8614 KW - Influenza Vaccines KW - 0 KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - Allied Health Personnel KW - Amantadine -- therapeutic use KW - Humans KW - Surveys and Questionnaires KW - Amantadine -- adverse effects KW - Aged KW - Middle Aged KW - Colorado KW - Male KW - Influenza Vaccines -- administration & dosage KW - Female KW - Nursing Staff KW - Influenza, Human -- prevention & control KW - Influenza, Human -- epidemiology KW - Disease Outbreaks -- prevention & control KW - Nursing Homes KW - Influenza, Human -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78877324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Treatment+of+an+influenza+A+outbreak+in+a+teaching+nursing+home.+Effectiveness+of+a+protocol+for+prevention+and+control.&rft.au=Peters%2C+N+L%3BOboler%2C+S%3BHair%2C+C%3BLaxson%2C+L%3BKost%2C+J%3BMeiklejohn%2C+G&rft.aulast=Peters&rft.aufirst=N&rft.date=1989-03-01&rft.volume=37&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-04 N1 - Date created - 1989-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gemfibrozil alone and in combination with lovastatin for treatment of hypertriglyceridemia in NIDDM. AN - 78866837; 2917701 AB - Hypertriglyceridemic patients with non-insulin-dependent diabetes mellitus (NIDDM) have an increased risk of coronary heart disease (CHD) and acute pancreatitis. To examine the potential of hypolipidemic drugs for therapy of lipoprotein abnormalities in NIDDM, 10 patients maintaining marked (plasma triglycerides greater than 500 mg/dl) and 6 with moderate (plasma triglycerides 250-500 mg/dl) hypertriglyceridemia, despite good glycemic control, were studied in two phases. In the first phase, gemfibrozil alone (600 mg twice daily) was compared with a placebo, and in the second phase a combination of gemfibrozil and lovastatin (20 mg twice daily) was compared with gemfibrozil alone in a randomized, double-blind, placebo-controlled crossover study. In markedly hypertriglyceridemic patients, gemfibrozil reduced plasma triglycerides by 52% and very-low-density lipoprotein cholesterol (VLDL-chol) by 55% and increased high-density lipoprotein cholesterol by 23% compared with a placebo. However, low-density lipoprotein cholesterol (LDL-chol) levels increased (42%), and LDL apolipoprotein B (apoB) levels remained unchanged. Addition of lovastatin to gemfibrozil effectively reduced total cholesterol (25%), LDL-chol (30%), and LDL-apoB (19%). Lovastatin further reduced plasma triglycerides (11%) and VLDL-chol (27%). However, in moderately hypertriglyceridemic patients, gemfibrozil or the combination therapy did not seem to offer benefits over the previously reported study with lovastatin alone. Glycemic control was maintained throughout the study. In conclusion, the beneficial effects of the combination therapy on lipoprotein levels in markedly hypertriglyceridemic NIDDM patients could decrease the risk of development of both acute pancreatitis and CHD. JF - Diabetes AU - Garg, A AU - Grundy, S M AD - Veterans Administration Medical Center, Dallas, Texas. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 364 EP - 372 VL - 38 IS - 3 SN - 0012-1797, 0012-1797 KW - Blood Glucose KW - 0 KW - Lipids KW - Lipoproteins KW - Lovastatin KW - 9LHU78OQFD KW - Gemfibrozil KW - Q8X02027X3 KW - Abridged Index Medicus KW - Index Medicus KW - Lipids -- blood KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Blood Glucose -- analysis KW - Lipoproteins -- blood KW - Male KW - Lovastatin -- adverse effects KW - Hypertriglyceridemia -- drug therapy KW - Hypertriglyceridemia -- complications KW - Lovastatin -- therapeutic use KW - Lovastatin -- administration & dosage KW - Gemfibrozil -- administration & dosage KW - Diabetes Mellitus, Type 2 -- complications KW - Hypertriglyceridemia -- blood KW - Gemfibrozil -- therapeutic use KW - Diabetes Mellitus, Type 2 -- blood KW - Gemfibrozil -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78866837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Gemfibrozil+alone+and+in+combination+with+lovastatin+for+treatment+of+hypertriglyceridemia+in+NIDDM.&rft.au=Garg%2C+A%3BGrundy%2C+S+M&rft.aulast=Garg&rft.aufirst=A&rft.date=1989-03-01&rft.volume=38&rft.issue=3&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-04 N1 - Date created - 1989-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Diabetes 1990 Oct;39(10):1313 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gender Differences in Marital Communication Patterns AN - 61577606; 198902604 AB - In an examination of conflict-resolution interactions of 55 couples, recruited via a newspaper advertisement for research participants for a study of marital communication, marital satisfaction is related to sequential & nonsequential communication patterns, with satisfaction differentiated on the basis of the degree of coercive vs affiliative communication. Results indicate that this pattern differs on the basis of gender. Fs & Ms are found to demonstrate different styles of response to dissatisfaction in marriage: Ms assume a coercive stance, & Fs an affiliative position, toward their partners. Drawing on systemic & gender-difference theoretical perspectives, these patterns are interpreted as attempts by individuals with different worldviews to resolve conflict. A view is discussed whereby system & gender differences can be integrated into a unified conceptual formulation on which to base future development in research & therapeutic interventions. 2 Tables, 1 Figure, 40 References. Modified HA JF - Family Process AU - White, Barbara B AD - Veterans Administration Medical Center, Palo Alto CA 94304 Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 89 EP - 106 VL - 28 IS - 1 SN - 0014-7370, 0014-7370 KW - marital satisfaction/communication, gender differences KW - Interpersonal Communication KW - Sex Differences KW - Conflict Resolution KW - Marital Satisfaction KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61577606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Process&rft.atitle=Gender+Differences+in+Marital+Communication+Patterns&rft.au=White%2C+Barbara+B&rft.aulast=White&rft.aufirst=Barbara&rft.date=1989-03-01&rft.volume=28&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Family+Process&rft.issn=00147370&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Marital Satisfaction; Conflict Resolution; Sex Differences; Interpersonal Communication ER - TY - JOUR T1 - A Study of the Interpersonal Behaviors of Male Batterers AN - 61063838; 90V5088 AB - The interpersonal behaviors of 100 male batterers were investigated using L. R. Ryan's Clinical Interpretation of the FIRO-B (Palo Alto, Calif: Consulting Psychologist Press, 1977) typological classification. The proportion of various types among batterers was compared to Ryan's Veterans' Administration & general population normative samples. Batterers were more likely to fall into categories of loner, rebel, & pessimist & were likely to be less outgoing, less intimate, & more cautious than the general population. The batterers demonstrated more difficulty with forming interpersonal relationships & expressing intimacy than the normative samples. The findings suggest that these individuals have difficulty in expressing affection & forming relationships & did not indicate that batterers in general have high needs to control others. 2 Tables, 15 References. HA JF - Journal of Interpersonal Violence AU - Allen, Kathryn AU - Calsyn, Donald A AU - Fehrenbach, Peter A AU - Benton, Gary AD - c/o Donald A. Calsyn -- Veterans' Administration Medical Center 116DDTP , 1660 S. Columbian Way Seattle WA 98108 Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 79 EP - 89 VL - 4 IS - 1 SN - 0886-2605, 0886-2605 KW - male batterers, interpersonal behaviors/relationships KW - empirical data KW - Offenders KW - Males KW - Battered Women KW - Spouse Abuse KW - article KW - 2858: studies in violence; studies in violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61063838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=A+Study+of+the+Interpersonal+Behaviors+of+Male+Batterers&rft.au=Allen%2C+Kathryn%3BCalsyn%2C+Donald+A%3BFehrenbach%2C+Peter+A%3BBenton%2C+Gary&rft.aulast=Allen&rft.aufirst=Kathryn&rft.date=1989-03-01&rft.volume=4&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Spouse Abuse; Battered Women; Males; Offenders ER - TY - JOUR T1 - Mechanics of the healed meniscus in a canine model AN - 20066360; 10093255 AB - The mechanical behavior of the intact canine stifle joint was studied, using a surgical model of meniscal injury and repair. Thirty-eight animals were divided into five study groups: Group S received only a sham arthro tomy (without a meniscal incision), Groups P13 and P26 received peripheral medial meniscal incisions, and Groups R13 and R26 received radial medial meniscus incisions. All meniscal incisions were repaired anatom ically with absorbable suture. Groups P13 and R13 were sacrificed at 13 weeks following surgery and Groups P26 and R26 at 26 weeks. Following sacrifice, the joints were subjected to gross and histologic ex amination, and structural and material properties test ing.All meniscal repairs healed, and the peripheral repairs were virtually invisible, with no articular damage. The radial repairs healed with 3 to 5 mm wide fibrovascular scars, and several joints demonstrated articular ero sions. The radial repair tissue contained unorganized collagen bundles and ground substance deficient in mucopolysaccharides.Groups S, P13 and P26 demonstrated no statistically significant differences between test and control limbs in compressive force-displacement behavior, input en ergy (E sub(I)), and ratio of dissipated to input energy (E sub(D)/E sub(I)). There were significant test-control differences in the load-displacement characteristics of Groups R13 (P < 0.05) and R26 (P < 0.05), with the repaired joint stiffer than the control. E sub(l) decreased 26% in Group R13 (not significant) and 34% in Group R26 (P < 0.05), while the ratio E sub(D)/E sub(l) increased from 27% to 44% in Group R13 (not significant) and from 31 % to 38% in Group R26 (P < 0.05).Medial compartment contact area did not change significantly in either peripheral repair group, but de creased by 25% in Group R13 (P < 0.05) and by 13% in Group R26 (P< 0.05). Yield stress, maximum stress, and Young's modulus decreased significantly (P < 0.05) relative to the controls in tensile tests of the radial repair tissue. There were no significant changes in these properties from 13 to 26 weeks.We concluded that in this animal model, the mechan ical function of the meniscus is restored following repair of peripheral longitudinal lesions ; however, it appears that in the radial repairs, progressive spreading at the repair site (filled by a fibrovascular scar) altered normal meniscal geometry and structure, adversely influencing mechanical function. Future studies may document whether protective measures (immobilization, limited weightbearing, etc.) can preserve normal mechanical function following repair of radial lesions. JF - American Journal of Sports Medicine AU - Newman, Alan P AU - Anderson, DRon AU - Daniels, A U AU - Dales, Mark C AD - Division of Orthopedic Surgery, University of Utah School of Medicine, Veterans Administration Medical Center, Salt Lake City, Utah Y1 - 1989/03// PY - 1989 DA - Mar 1989 SP - 164 EP - 175 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 17 IS - 2 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Stress tests KW - Statistics KW - Behavior KW - Surgery KW - Mechanics KW - Connective tissue KW - Sports medicine KW - Immobilization KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20066360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Mechanics+of+the+healed+meniscus+in+a+canine+model&rft.au=Newman%2C+Alan+P%3BAnderson%2C+DRon%3BDaniels%2C+A+U%3BDales%2C+Mark+C&rft.aulast=Newman&rft.aufirst=Alan&rft.date=1989-03-01&rft.volume=17&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658901700205 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stress tests; Statistics; Behavior; Surgery; Mechanics; Connective tissue; Sports medicine; Immobilization; Joints DO - http://dx.doi.org/10.1177/036354658901700205 ER - TY - JOUR T1 - Infused L-histidinol and cisplatin: schedule, specificity, and proliferation dependence. AN - 78850549; 2913328 AB - The dose and schedule requirements found for the combination of L-histidinol and 5-fluorouracil (5-FU) were concordant with those for the combination of L-histidinol and cisplatin. Furthermore, cisplatin-L-histidinol was active against colon 26 tumor, an adenocarcinoma that developed in a BALB/c female mouse and that has been grown as a solid tumor. The toxicity of cisplatin was prevented only when cisplatin was given before L-histidinol. Studies of L-histidinol and 5-FU had similar results. For (DBA/2 X BALB/c)F1 mice, 50 mg of L-histidinol per mouse was required for protection; for hematopoietic precursor cells, protection was dependent on the dose of L-histidinol. In contrast, both L1210 leukemia cells and colon 26 adenocarcinoma cells were more efficiently killed by combinations of L-histidinol and cisplatin. This effect depended on the doses of L-histidinol and cisplatin, a finding similar to the finding for hematopoietic precursor cells. JF - Journal of the National Cancer Institute AU - Edelstein, M B AD - Section of Hematology and Oncology, Veterans Administration Medical Center, Allen Park, MI 48101. Y1 - 1989/02/15/ PY - 1989 DA - 1989 Feb 15 SP - 298 EP - 301 VL - 81 IS - 4 SN - 0027-8874, 0027-8874 KW - Histidinol KW - 501-28-0 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Histidinol -- administration & dosage KW - Mice, Inbred Strains KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Mice KW - Colony-Forming Units Assay KW - Hematopoietic Stem Cells -- drug effects KW - Cisplatin -- administration & dosage KW - Colonic Neoplasms -- drug therapy KW - Leukemia L1210 -- drug therapy KW - Colonic Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78850549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Infused+L-histidinol+and+cisplatin%3A+schedule%2C+specificity%2C+and+proliferation+dependence.&rft.au=Edelstein%2C+M+B&rft.aulast=Edelstein&rft.aufirst=M&rft.date=1989-02-15&rft.volume=81&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Disease associated with Clostridium difficile infection. AN - 78831782; 2643913 JF - Annals of internal medicine AU - Gerding, D N AD - Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1989/02/15/ PY - 1989 DA - 1989 Feb 15 SP - 255 EP - 257 VL - 110 IS - 4 SN - 0003-4819, 0003-4819 KW - Cytotoxins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Feces -- microbiology KW - Sigmoidoscopy KW - Feces -- analysis KW - Cross Infection -- transmission KW - Humans KW - Cross Infection -- epidemiology KW - Diarrhea -- etiology KW - Enterocolitis, Pseudomembranous -- etiology KW - Cytotoxins -- analysis KW - Clostridium Infections -- transmission KW - Clostridium Infections -- complications KW - Clostridium Infections -- diagnosis KW - Clostridium Infections -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78831782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Disease+associated+with+Clostridium+difficile+infection.&rft.au=Gerding%2C+D+N&rft.aulast=Gerding&rft.aufirst=D&rft.date=1989-02-15&rft.volume=110&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-27 N1 - Date created - 1989-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action. AN - 78886021; 2647517 AB - Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes. JF - FEBS letters AU - Vila, M C AU - Cooper, D R AU - Davis, J S AU - Standaert, M L AU - Farese, R V AD - Veterans Administration Hospital, Tampa, FL. Y1 - 1989/02/13/ PY - 1989 DA - 1989 Feb 13 SP - 177 EP - 180 VL - 244 IS - 1 SN - 0014-5793, 0014-5793 KW - Insulin KW - 0 KW - Phosphoproteins KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphorylation KW - Electrophoresis, Polyacrylamide Gel KW - Kinetics KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Isoelectric Focusing KW - Molecular Weight KW - Cell Line KW - Protein Kinase C -- metabolism KW - Muscles -- enzymology KW - Insulin -- pharmacology KW - Phosphoproteins -- metabolism KW - Muscles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78886021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Studies+of+in+vivo+phosphorylated+proteins+in+BC3H-1+myocytes+suggest+that+protein+kinase+C+is+involved+in+insulin+action.&rft.au=Vila%2C+M+C%3BCooper%2C+D+R%3BDavis%2C+J+S%3BStandaert%2C+M+L%3BFarese%2C+R+V&rft.aulast=Vila&rft.aufirst=M&rft.date=1989-02-13&rft.volume=244&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-21 N1 - Date created - 1989-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative effectiveness and costs of inpatient and outpatient detoxification of patients with mild-to-moderate alcohol withdrawal syndrome. AN - 78834985; 2913493 AB - We compared the effectiveness, safety, and costs of outpatient (n = 87) and inpatient (n = 77) detoxification from alcohol in a randomized, prospective trial involving 164 male veterans of low socioeconomic status. The outpatients were evaluated medically and psychiatrically and then were prescribed decreasing doses of oxazepam on the basis of daily clinic visits. The inpatient program combined comprehensive psychiatric and medical evaluation, detoxification with oxazepam, and the initiation of rehabilitation treatment. The mean duration of treatment was significantly shorter for outpatients (6.5 days) than for inpatients (9.2 days). On the other hand, significantly more inpatients (95 percent) than outpatient (72 percent) completed detoxification. There were no serious medical complications in either group. Outcome evaluations completed at one and six months for 93 and 85 percent of the patients, respectively, showed substantial improvement in both groups at both follow-up periods. At one month there were fewer alcohol-related problems among inpatients and fewer medical problems among outpatients. However, no group differences were found at the six-month follow-up, nor were differences found in the subsequent use of other alcoholism-treatment services. Costs were substantially greater for inpatients ($3,319 to $3,665 per patient) than for outpatients ($175 to $388). We conclude that outpatient medical detoxification is an effective, safe, and low-cost treatment for patients with mid-to-moderate symptoms of alcohol withdrawal. JF - The New England journal of medicine AU - Hayashida, M AU - Alterman, A I AU - McLellan, A T AU - O'Brien, C P AU - Purtill, J J AU - Volpicelli, J R AU - Raphaelson, A H AU - Hall, C P AD - Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1989/02/09/ PY - 1989 DA - 1989 Feb 09 SP - 358 EP - 365 VL - 320 IS - 6 SN - 0028-4793, 0028-4793 KW - Ethanol KW - 3K9958V90M KW - Oxazepam KW - 6GOW6DWN2A KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Random Allocation KW - Humans KW - Safety KW - Patient Dropouts KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Follow-Up Studies KW - Pennsylvania KW - Time Factors KW - Oxazepam -- administration & dosage KW - Male KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- rehabilitation KW - Ambulatory Care -- economics KW - Hospitalization -- economics KW - Substance Withdrawal Syndrome -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78834985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Comparative+effectiveness+and+costs+of+inpatient+and+outpatient+detoxification+of+patients+with+mild-to-moderate+alcohol+withdrawal+syndrome.&rft.au=Hayashida%2C+M%3BAlterman%2C+A+I%3BMcLellan%2C+A+T%3BO%27Brien%2C+C+P%3BPurtill%2C+J+J%3BVolpicelli%2C+J+R%3BRaphaelson%2C+A+H%3BHall%2C+C+P&rft.aulast=Hayashida&rft.aufirst=M&rft.date=1989-02-09&rft.volume=320&rft.issue=6&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-24 N1 - Date created - 1989-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 1989 Aug 10;321(6):399-401 [2501685] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx. AN - 78954851; 2714367 AB - Intravenous administration of 2-[2-methoxyethoxy]-ethyl 8-[cis-2-n-octylcyclopropyl]-octanoate (A2C) was found to disorder brain membranes but did not produce intoxication or anesthesia in mice. The abilities of A2C and an anesthetic (benzyl alcohol) to inhibit [35S]t-butylbicyclophosphorothionate (TBPS) binding, and modify gamma-aminobutyric acid (GABA) receptor-mediated 36Cl- influx into brain vesicles were then compared. Both of the perturbants inhibited [35S]TBPS binding at the same concentrations at which they reduced membrane order; however, the anesthetic was nearly 4 times more effective in reducing [35S]TBPS binding than was A2C. Muscimol-stimulated 36Cl- uptake was enhanced by benzyl alcohol at a concentration which produced little or no change in membrane order. Concentrations of both A2C and benzyl alcohol which reduced membrane order inhibited muscimol-stimulated 36Cl- influx. Similarly, membrane order and muscimol-activated 36Cl- uptake were reduced in brain vesicles prepared from mice which had received A2C in vivo. The effects of anesthetics on the GABAA receptor-chloride channel complex were analyzed by a two site model of action in which a 'perturbant' site is responsible for decreased 36Cl- uptake; but a distinct 'anesthetic' site is responsible for augmentation of chloride flux and anesthesia. JF - European journal of pharmacology AU - Buck, K J AU - Allan, A M AU - Harris, R A AD - Veterans Administration Medical Center, Denver, CO. Y1 - 1989/02/07/ PY - 1989 DA - 1989 Feb 07 SP - 359 EP - 367 VL - 160 IS - 3 SN - 0014-2999, 0014-2999 KW - Benzyl Alcohols KW - 0 KW - Bridged Bicyclo Compounds KW - Bridged Bicyclo Compounds, Heterocyclic KW - Chlorides KW - Radioisotopes KW - Stearates KW - Stearic Acids KW - Muscimol KW - 2763-96-4 KW - Chlorine KW - 4R7X1O2820 KW - A(2)C KW - 54050-62-3 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - tert-butylbicyclophosphorothionate KW - 70636-86-1 KW - Index Medicus KW - Membranes -- drug effects KW - Animals KW - Mice, Inbred ICR KW - Synaptosomes -- drug effects KW - Temperature KW - Membrane Fluidity -- drug effects KW - Membranes -- metabolism KW - Bridged Bicyclo Compounds -- metabolism KW - Mice KW - gamma-Aminobutyric Acid -- metabolism KW - Benzyl Alcohols -- pharmacology KW - Synaptosomes -- metabolism KW - Male KW - Stearic Acids -- pharmacology KW - Anesthesia KW - Stearates -- pharmacology KW - Brain Chemistry -- drug effects KW - Chlorides -- metabolism KW - Muscimol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78954851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Fluidization+of+brain+membranes+by+A2C+does+not+produce+anesthesia+and+does+not+augment+muscimol-stimulated+36Cl-+influx.&rft.au=Buck%2C+K+J%3BAllan%2C+A+M%3BHarris%2C+R+A&rft.aulast=Buck&rft.aufirst=K&rft.date=1989-02-07&rft.volume=160&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-20 N1 - Date created - 1989-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ideational apraxia: a deficit in tool selection and use. AN - 85272919; pmid-2465733 AB - We report a 67-year-old left-handed man who exhibited an ideational apraxia in both clinical and nonclinical natural settings following a right hemisphere infarction. His inability to use tools could not be explained by a motor production deficit (ideomotor apraxia), because he made content errors and could not match tools with objects. His deficit could not be attributed to an agnosia or language comprehension deficit, because he could name tools and point to tools on command. Based on our testing, it appeared that this patient had a loss of knowledge related to tool use. JF - Annals of Neurology AU - Ochipa, C AU - Rothi L J AU - Heilman, K M AD - Audiology-Speech Pathology Service, Veterans Administration Medical Center, Gainesville, FL. PY - 1989 SP - 190 EP - 193 VL - 25 IS - 2 SN - 0364-5134, 0364-5134 KW - Agnosia KW - Cerebral Infarction KW - Aphasia KW - Human KW - Tomography, X-Ray Computed KW - Aged KW - Dominance, Cerebral KW - Anomia KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Apraxias KW - Neuropsychological Tests KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85272919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Neurology&rft.atitle=Ideational+apraxia%3A+a+deficit+in+tool+selection+and+use.&rft.au=Ochipa%2C+C%3BRothi+L+J%3BHeilman%2C+K+M&rft.aulast=Ochipa&rft.aufirst=C&rft.date=1989-02-01&rft.volume=25&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Annals+of+Neurology&rft.issn=03645134&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Reconstruction of intermediate sized mucosal defects with the pectoralis major myofascial flap. AN - 85217098; pmid-2921784 AB - An uncovered pectoralis major muscle flap (PMF) was utilized in 12 patients for reconstruction of mucosal defects of intermediate size. The PMF is nonhair-bearing and thinner and more flexible than the myocutaneous flap. Epithelialization of the PMF occurs slowly but results in a mucosal surface that is nonkeratinized and closely resembles normal. The paddle of the PMF contracts as much as 75% during healing. However, none of our patients developed deficits attributable to contracture of the flap, presumably because only modest-sized defects were repaired. The PMF is useful for reconstruction of intermediate-sized defects approximately 6 x 6 cm, defects that are too large to close with local flaps and tend to be too small to be closed conveniently with a bulky myocutaneous flap. Contracture of the PMF precludes its use for reconstruction of large defects. JF - The Journal of Otolaryngology AU - Moloy, P J AD - ENT Section, Veterans Administration Medical Center, Long Beach, California. PY - 1989 SP - 32 EP - 35 VL - 18 IS - 1 SN - 0381-6605, 0381-6605 KW - Pectoralis Muscles KW - Oropharynx KW - Mouth Mucosa KW - Human KW - Aged KW - Middle Age KW - Pharyngeal Neoplasms KW - Carcinoma, Squamous Cell KW - Male KW - Oropharyngeal Neoplasms KW - Surgical Flaps UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85217098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Otolaryngology&rft.atitle=Reconstruction+of+intermediate+sized+mucosal+defects+with+the+pectoralis+major+myofascial+flap.&rft.au=Moloy%2C+P+J&rft.aulast=Moloy&rft.aufirst=P&rft.date=1989-02-01&rft.volume=18&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Otolaryngology&rft.issn=03816605&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of butylated hydroxytoluene upon PUVA-tumorigenesis and induction of ornithine decarboxylase activity in the mouse. AN - 78987266; 2498483 AB - Psoralen photochemotherapy (PUVA) is widely used in the treatment of psoriasis. Some therapy regimen have been associated with increased risk of skin cancer. Free radical species are thought to play a role in psoralen phototoxicity and photocarcinogenesis. It has been reported that the antioxidant butylated hydroxytoluene (BHT) inhibits acute phototoxicity by PUVA but does not reduce therapeutic efficacy. It has also been shown that BHT inhibits UVB-induced erythema, tumorigenesis and induction of ornithine decarboxylase (ODC) activity--ODC activity is thought by some to be associated with tumor promotion. Therefore, we have investigated the effect of BHT on psoralen tumorigenesis and PUVA-induced epidermal ODC activity. SKH-Hr-1 hairless albino mice were treated with topically applied 8-MOP and exposed to UVA (3X weekly) for 31 weeks with and without BHT administered either in the diet or topically. Induction of ODC activity was determined in similar experimental groups 24 h after a single exposure to UVA. Neither route of BHT administration had any effect on 8-MOP phototumorigenesis. However, BHT when administered in the diet reduced induction of ODC activity by 40% (p less than 0.05). These data indicate different mechanisms for UVB- and PUVA-induced carcinogenesis and again bring into question the relationship between induction of ODC activity and photocarcinogenesis. JF - Journal of photochemistry and photobiology. B, Biology AU - Black, H S AU - Young, A R AU - Gibbs, N K AD - Photobiology Laboratory, Veterans Administration Medical Center, Houston, TX. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 91 EP - 100 VL - 3 IS - 1 SN - 1011-1344, 1011-1344 KW - Ornithine Decarboxylase Inhibitors KW - 0 KW - Butylated Hydroxytoluene KW - 1P9D0Z171K KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Animals KW - Enzyme Induction KW - Mice KW - Female KW - PUVA Therapy -- adverse effects KW - Skin Neoplasms -- etiology KW - Butylated Hydroxytoluene -- pharmacology KW - Ornithine Decarboxylase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78987266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.atitle=Effects+of+butylated+hydroxytoluene+upon+PUVA-tumorigenesis+and+induction+of+ornithine+decarboxylase+activity+in+the+mouse.&rft.au=Black%2C+H+S%3BYoung%2C+A+R%3BGibbs%2C+N+K&rft.aulast=Black&rft.aufirst=H&rft.date=1989-02-01&rft.volume=3&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.issn=10111344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-05 N1 - Date created - 1989-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transdermal clonidine compared with hydrochlorothiazide as monotherapy in elderly hypertensive males. AN - 78975995; 2715369 AB - Sixteen of 22 elderly male patients (aged 60-74 years) who had previously taken only hydrochlorothiazide 50 mg completed a study evaluating the safety, efficacy, and tolerability of 12-20 weeks of transdermal clonidine (Catapres TTS) as monotherapy for mild hypertension. Thirteen of the sixteen patients (81%) responded to transdermal clonidine which was begun after 28 days of placebo. Five patients discontinued transdermal clonidine therapy because of intolerable skin irritation, and one because of daytime fatigue. Clonidine caused none of the metabolic effects we observed with hydrochlorothiazide: no change in serum potassium, uric acid, cholesterol, or triglyceride. Eleven of the 22 patients (50%) who began the study experienced a skin reaction under the transdermal clonidine patch. The incidence of dry mouth and fatigue in patients using transdermal clonidine was dose-related and similar to reports of dry mouth and fatigue in patients taking oral clonidine tablets. Rebound hypertension occurred in one patient upon withdrawal of transdermal clonidine. There was no effect of transdermal clonidine or hydrochlorothiazide on cognitive function or emotional state tested with three questionnaires. Overall, transdermal clonidine, in various doses, was as effective as hydrochlorothiazide in elderly male hypertensive patients. The effectiveness of both was inversely proportional to the level of untreated blood pressure. The high incidence of skin reactions limited prolonged use of transdermal clonidine in our patients. JF - Journal of clinical pharmacology AU - Schmidt, G R AU - Schuna, A A AU - Goodfriend, T L AD - William Middleton Memorial Veterans Administration Hospital, Madison, WI. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 133 EP - 139 VL - 29 IS - 2 SN - 0091-2700, 0091-2700 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Heart Rate -- drug effects KW - Administration, Cutaneous KW - Humans KW - Quality of Life KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Hydrochlorothiazide -- administration & dosage KW - Hypertension -- physiopathology KW - Clonidine -- administration & dosage KW - Clonidine -- adverse effects KW - Hydrochlorothiazide -- therapeutic use KW - Clonidine -- therapeutic use KW - Hypertension -- drug therapy KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78975995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Transdermal+clonidine+compared+with+hydrochlorothiazide+as+monotherapy+in+elderly+hypertensive+males.&rft.au=Schmidt%2C+G+R%3BSchuna%2C+A+A%3BGoodfriend%2C+T+L&rft.aulast=Schmidt&rft.aufirst=G&rft.date=1989-02-01&rft.volume=29&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-15 N1 - Date created - 1989-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Graded neuropsychological impairment and elevated gamma-glutamyl transferase in chronic alcoholic men. AN - 78902546; 2564260 AB - This study hypothesizes that distinct biochemical and metabolic disturbances associated with liver injury may be related to specific cognitive changes in alcoholics. In 132 alcoholic men admitted to an alcohol treatment program, increases in gamma-glutamyl transferase (GGT) values were correlated with impairment in several measures of visuoperceptual and visuoconceptual functioning. The association between plasma levels of GGT and neuropsychological performance was independent of the relative contribution of other laboratory measures of liver injury and of alcohol consumption histories. These observations support the hypothesis that elevated levels of GGT are distinctly associated with neuropsychological deficits and suggest that possible mechanisms beyond severe hepatic dysfunction and alcohol consumption underlie cognitive deficits in alcoholics. JF - Alcoholism, clinical and experimental research AU - Irwin, M AU - Smith, T L AU - Butters, N AU - Brown, S AU - Baird, S AU - Grant, I AU - Schuckit, M A AD - Clinical Center for Research on Alcoholism, San Diego Veterans Administration Medical Center, La Jolla, CA 92161. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 99 EP - 103 VL - 13 IS - 1 SN - 0145-6008, 0145-6008 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Wechsler Scales KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Alcoholism -- diagnosis KW - gamma-Glutamyltransferase -- blood KW - Neuropsychological Tests KW - Liver Diseases, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78902546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Graded+neuropsychological+impairment+and+elevated+gamma-glutamyl+transferase+in+chronic+alcoholic+men.&rft.au=Irwin%2C+M%3BSmith%2C+T+L%3BButters%2C+N%3BBrown%2C+S%3BBaird%2C+S%3BGrant%2C+I%3BSchuckit%2C+M+A&rft.aulast=Irwin&rft.aufirst=M&rft.date=1989-02-01&rft.volume=13&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differences in cyclophosphamide-induced suppression of cricket predation in selectively bred strains of taste-aversion prone and resistant rats. AN - 78897518; 2923664 AB - Cyclophosphamide-induced conditioned suppression of cricket predation was observed in taste-aversion-prone (TAP) but not in taste-aversion-resistant (TAR) rats. These TAP and TAR strains had been selectively bred for efficient or inefficient acquisition of cyclophosphamide-induced saccharin taste aversions (TAs). Equivalent preconditioning cricket predation was practiced by nonfasted subjects of both strains. TAR rats that ate crickets before a cyclophosphamide injection were thereafter voracious predators as were saline-injected and pseudoconditioning controls of both strains. However, conditioned TAP rats subsequently displayed a marked suppression of cricket predation. Predation can provide a deprivation-free and species-natural consummatory response for studies of strain differences in TA conditionability of TAP and TAR rats. In addition, the present results indicate that TAP and TAR strain differences in TA conditionability are not restricted to the saccharin solution that was the conditioned stimulus basis of prior strain development. JF - Behavioral neuroscience AU - Elkins, R L AU - Gerardot, R J AU - Hobbs, S H AD - Veterans Administration Medical Center, Augusta, Georgia. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 112 EP - 116 VL - 103 IS - 1 SN - 0735-7044, 0735-7044 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Rats KW - Animals KW - Gryllidae KW - Male KW - Avoidance Learning -- physiology KW - Taste -- physiology KW - Predatory Behavior -- physiology KW - Predatory Behavior -- drug effects KW - Avoidance Learning -- drug effects KW - Taste -- drug effects KW - Appetitive Behavior -- physiology KW - Cyclophosphamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78897518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Differences+in+cyclophosphamide-induced+suppression+of+cricket+predation+in+selectively+bred+strains+of+taste-aversion+prone+and+resistant+rats.&rft.au=Elkins%2C+R+L%3BGerardot%2C+R+J%3BHobbs%2C+S+H&rft.aulast=Elkins&rft.aufirst=R&rft.date=1989-02-01&rft.volume=103&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-24 N1 - Date created - 1989-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diminished proliferative response of con A-blast cells to interleukin 2 in adult rats exposed to ethanol in utero. AN - 78884331; 2646980 AB - The fetal alcohol syndrome is associated with altered immunity. We attempted to delineate the mechanism of the decline in cell-mediated immunity observed by others by using rats which were exposed to alcohol in utero and tested for immune integrity 3 months after birth. We found that concanavalin A-stimulated T-lymphoblast (Con A T-blast) cells that were obtained from ethanol-exposed rats had significantly diminished proliferative responses to both crude and recombinant interleukin 2 compared to those obtained from normal and nutritional controls. The blunted response of Con A T-blast cells to interleukin 2 may be a biomarker of fetal exposure to alcohol. JF - Alcoholism, clinical and experimental research AU - Norman, D C AU - Chang, M P AU - Castle, S C AU - Van Zuylen, J E AU - Taylor, A N AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, West Los Angeles, CA 90073. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 69 EP - 72 VL - 13 IS - 1 SN - 0145-6008, 0145-6008 KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Concanavalin A KW - 11028-71-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Immune Tolerance -- drug effects KW - Animals KW - Recombinant Proteins -- pharmacology KW - T-Lymphocytes -- drug effects KW - Male KW - Female KW - Pregnancy KW - Lymphocyte Activation -- drug effects KW - Interleukin-2 -- pharmacology KW - Concanavalin A -- immunology KW - Fetal Alcohol Spectrum Disorders -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78884331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Diminished+proliferative+response+of+con+A-blast+cells+to+interleukin+2+in+adult+rats+exposed+to+ethanol+in+utero.&rft.au=Norman%2C+D+C%3BChang%2C+M+P%3BCastle%2C+S+C%3BVan+Zuylen%2C+J+E%3BTaylor%2C+A+N&rft.aulast=Norman&rft.aufirst=D&rft.date=1989-02-01&rft.volume=13&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of mineral and vitamin supplementation on the alcohol-induced fatty liver and microsomal induction. AN - 78884258; 2646968 AB - In rats fed ethanol (36% of total energy) for 1 month as part of a standard liquid diet, significant increases in hepatic lipids, microsomal cytochrome P-450, and in the activity of the microsomal ethanol oxidizing system were observed. Similar effects were noted in another group of animals treated with the same ethanol-containing diet, except that the content of minerals and vitamins was increased by 50%. Body weight gains were also comparable in these groups. It is concluded that these effects of ethanol are not due to vitamin and mineral deficiency secondary to decreased food intake but rather can be attributed to ethanol itself. JF - Alcoholism, clinical and experimental research AU - Lieber, C S AU - DeCarli, L M AD - Section of Liver Disease and Nutrition, Bronx Veterans Administration Medical Center, New York 10468. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 142 EP - 143 VL - 13 IS - 1 SN - 0145-6008, 0145-6008 KW - Minerals KW - 0 KW - Vitamins KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Alcohol Oxidoreductases KW - EC 1.1.- KW - alcohol dehydrogenase (NADP+) KW - EC 1.1.1.2 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Enzyme Induction KW - Male KW - Minerals -- administration & dosage KW - Vitamins -- administration & dosage KW - Fatty Liver, Alcoholic -- pathology KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Alcohol Oxidoreductases -- biosynthesis KW - Microsomes, Liver -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78884258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effects+of+mineral+and+vitamin+supplementation+on+the+alcohol-induced+fatty+liver+and+microsomal+induction.&rft.au=Lieber%2C+C+S%3BDeCarli%2C+L+M&rft.aulast=Lieber&rft.aufirst=C&rft.date=1989-02-01&rft.volume=13&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testosterone administration inhibits gonadotropin secretion by an effect directly on the human pituitary. AN - 78881007; 2493030 AB - Testosterone (T) administration slows LH pulse frequency in man, presumably by an effect on the hypothalamic GnRH pulse generator, but it also may have a direct action on the pituitary. To determine if T does indeed affect gonadotropin secretion by acting directly on the pituitary, we studied the effect of T on GnRH-stimulated gonadotropin secretion. Six men with hypogonadotropic hypogonadism were treated with physiological doses of GnRH (5 micrograms every 2 h, sc by automatic infusion pump) for 6 weeks. Once their gonadotropin levels were normal, the men received a supraphysiological dosage of T enanthate (200 mg, im, weekly for 8 weeks) in addition to GnRH. They then received GnRH alone for a final 8-week period. Blood sampling was performed every 10 min for 8 h at the end of each of the three study periods. T administration suppressed the mean serum LH level to about 50% of the value during GnRH alone [18 +/- 2 (+/- SE) vs. 37 +/- 2 micrograms/L; P less than 0.05] and suppressed the mean serum FSH level to about 30% of the value during GnRH alone (39 +/- 6 vs. 128 +/- 28 micrograms/L; P less than 0.05). Eight weeks after stopping T, while continuing GnRH alone, serum LH and FSH levels were similar to those at the end of the first period of GnRH administration. The mean LH response to GnRH was reduced during T administration (17 +/- 3 micrograms/L) compared to that during the initial period of GnRH alone (31 +/- 4 micrograms/L; P less than 0.05). Serum T and estradiol levels were in the low normal range after GnRH alone before T administration (11 +/- 2 nmol/L and 105 +/- 17 pmol/L, respectively) and increased to just above the normal adult ranges after 8 weeks of T administration (36 +/- 5 nmol/L and 264 +/- 49 pmol/L, respectively). These results demonstrate that T and/or its metabolites inhibit LH and FSH secretion by a GnRH-independent mechanism, probably directly on the pituitary gland, in man. JF - The Journal of clinical endocrinology and metabolism AU - Sheckter, C B AU - Matsumoto, A M AU - Bremner, W J AD - Medical Service, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 397 EP - 401 VL - 68 IS - 2 SN - 0021-972X, 0021-972X KW - Gonadotropins KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Testosterone KW - 3XMK78S47O KW - Estradiol KW - 4TI98Z838E KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hypothalamus -- physiology KW - Hypothalamus -- secretion KW - Hypothalamus -- drug effects KW - Humans KW - Follicle Stimulating Hormone -- blood KW - Rats KW - Luteinizing Hormone -- secretion KW - Estradiol -- blood KW - Adult KW - Hypogonadism -- drug therapy KW - Luteinizing Hormone -- blood KW - Drug Synergism KW - Follicle Stimulating Hormone -- secretion KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Male KW - Gonadotropins -- blood KW - Pituitary Gland, Anterior -- drug effects KW - Testosterone -- pharmacology KW - Pituitary Gland, Anterior -- secretion KW - Gonadotropins -- antagonists & inhibitors KW - Pituitary Gland, Anterior -- physiology KW - Gonadotropins -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78881007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Testosterone+administration+inhibits+gonadotropin+secretion+by+an+effect+directly+on+the+human+pituitary.&rft.au=Sheckter%2C+C+B%3BMatsumoto%2C+A+M%3BBremner%2C+W+J&rft.aulast=Sheckter&rft.aufirst=C&rft.date=1989-02-01&rft.volume=68&rft.issue=2&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-27 N1 - Date created - 1989-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of chronic ethanol administration on protein catabolism in rat liver. AN - 78877067; 2646978 AB - Hepatic protein catabolism was measured in rats which were pair-fed a liquid diet containing either ethanol or isocaloric maltose-dextrin (control diet). Within 12 days after initiation of pair feeding, the level of total hepatic protein in ethanol-fed rats was 26% higher than that in pair-fed control rats. During this time interval, the catabolic rates of both short-lived [3H]puromycin-labeled proteins and long-lived native [14C]bicarbonate-labeled proteins were measured in the two groups of animals. The degradation rate of short-lived [3H]puromycinyl proteins and peptides was the same in ethanol-fed and pair-fed control rats. However, the overall catabolic rate of long-lived proteins in rats fed the ethanol liquid diet for 2-10 days was 37-40% lower than that in pair-fed controls. This difference in protein turnover was not a general phenomenon, since the time-dependent decay of [14C]proteins in the hepatic microsome fraction of ethanol-fed rats was 33% slower than that in pair-fed controls, but the apparent rate of cytosolic protein catabolism was the same in both groups of animals. The differences in protein turnover did not reflect quantitative changes in lysosomal proteases since the activities of four hepatic lysosomal cathepsins were unaffected by alcohol administration. When rats were subjected to longer periods of pair feeding (16-25 days), the difference in overall hepatic protein catabolism between ethanol-fed rats and their pair-fed controls was considerably attenuated.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Donohue, T M AU - Zetterman, R K AU - Tuma, D J AD - Liver Study Unit, Veterans Administration Medical Center, Omaha, NE 68105. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 49 EP - 57 VL - 13 IS - 1 SN - 0145-6008, 0145-6008 KW - Peptides KW - 0 KW - Proteins KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Cytosol -- metabolism KW - Animals KW - Microsomes, Liver -- metabolism KW - Peptides -- metabolism KW - Male KW - Liver Diseases, Alcoholic -- metabolism KW - Ethanol -- administration & dosage KW - Liver -- metabolism KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78877067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effect+of+chronic+ethanol+administration+on+protein+catabolism+in+rat+liver.&rft.au=Donohue%2C+T+M%3BZetterman%2C+R+K%3BTuma%2C+D+J&rft.aulast=Donohue&rft.aufirst=T&rft.date=1989-02-01&rft.volume=13&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardiac hypertrophy induced by thyroid hormone is independent of loading conditions and beta adrenoceptor blockade. AN - 78870723; 2537405 AB - This study was designed to determine whether thyroid hormone (T4) produces cardiac hypertrophy and alters ventricular function by direct effects on the heart or by alterations in adrenergic stimulation or changes in the peripheral circulation. Rats were treated with captopril (4 mg/ml of drinking water), propranolol (0.5 mg/ml of drinking water), hydralazine (80 mg/l of drinking water) or the combination of captopril and propranolol with and without T4 (15 micrograms/100 g b.w. i.p.). After 10 days, T4 increased (P less than .01) heart rate, left ventricular (LV) dP/dt and LV weight/body weight, but did not alter LV systolic pressure (SP) or enddiastolic pressure (EDP). Compared to treatment with T4 alone, captopril plus T4 decreased LV SP (P less than .05) and LV EDP (P less than .01); however, heart rate, LV dP/dt and LV weight/body weight were unchanged. Treatment with T4 plus propranolol decreased heart rate and LV EDP (P less than .05) compared to T4 alone; however, LV SP, LV dP/dt and LV weight/body weight were unchanged (P greater than .05). Hydralazine did not alter (P greater than .05) heart rate, LV SP, LV EDP or prevent the development of increased LV weight/body weight when given with T4; however, LV dP/dt was slightly decreased (P less than .05). Treatment with the combination of captopril and propranolol did not alter (P greater than .05) heart rate, LV SP, LV EDP or LV dP/dt and also failed to prevent the development of increased LV weight/body weight and LV dP/dt when given with T4.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Bedotto, J B AU - Gay, R G AU - Graham, S D AU - Morkin, E AU - Goldman, S AD - Department of Internal Medicine, Veterans Administration Medical Center, Tucson, Arizona. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 632 EP - 636 VL - 248 IS - 2 SN - 0022-3565, 0022-3565 KW - Isoenzymes KW - 0 KW - Receptors, Adrenergic, beta KW - Thyroid Hormones KW - Hydralazine KW - 26NAK24LS8 KW - Captopril KW - 9G64RSX1XD KW - Propranolol KW - 9Y8NXQ24VQ KW - Myosins KW - EC 3.6.4.1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Isoenzymes -- analysis KW - Animals KW - Hydralazine -- pharmacology KW - Propranolol -- pharmacology KW - Myosins -- analysis KW - Heart -- drug effects KW - Male KW - Heart -- physiopathology KW - Captopril -- pharmacology KW - Thyroid Hormones -- pharmacology KW - Cardiomegaly -- chemically induced KW - Receptors, Adrenergic, beta -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78870723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Cardiac+hypertrophy+induced+by+thyroid+hormone+is+independent+of+loading+conditions+and+beta+adrenoceptor+blockade.&rft.au=Bedotto%2C+J+B%3BGay%2C+R+G%3BGraham%2C+S+D%3BMorkin%2C+E%3BGoldman%2C+S&rft.aulast=Bedotto&rft.aufirst=J&rft.date=1989-02-01&rft.volume=248&rft.issue=2&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-03 N1 - Date created - 1989-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Male alcoholics' perceptions of their fathers. AN - 78863349; 2915213 AB - Male alcoholics who describe their fathers as alcoholic are significantly less likely to perceive themselves as like their fathers when compared with male alcoholics who do not describe their fathers as alcoholic. The findings are discussed in the context of the importance of family history as it relates to treatment interventions with male alcoholics. JF - The Journal of nervous and mental disease AU - Mulinski, P AD - Social Work Service, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 101 EP - 104 VL - 177 IS - 2 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Perception KW - Humans KW - Male KW - Father-Child Relations KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78863349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Male+alcoholics%27+perceptions+of+their+fathers.&rft.au=Mulinski%2C+P&rft.aulast=Mulinski&rft.aufirst=P&rft.date=1989-02-01&rft.volume=177&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heparin-associated thrombocytopenia: observations on the mechanism of platelet aggregation. AN - 78857315; 2783722 AB - We investigated the mechanism of heparin-mediated platelet aggregation in 11 patients with heparin-associated thrombocytopenia. Severe thrombocytopenia (16,000 to 66,000 platelets/microliters) developed in each patient during heparin therapy, and platelet aggregation occurred in vitro when heparin was added to mixtures of patient plasma and normal platelet-rich plasma. In 10 patients, heparin-initiated platelet aggregation was inhibited by preincubation of mixtures of normal platelet-rich plasma and heparin-associated thrombocytopenia plasma with monoclonal antiglycoprotein Ib antibodies 6D1 or LJ-Ib1. Both antibodies are directed against the von Willebrand factor binding site on glycoprotein Ib and inhibit only ristocetin-induced platelet agglutination. Purified immunoglobulin G (IgG) from patients with heparin-associated thrombocytopenia also supported heparin-induced aggregation, but equivalent amounts of antigen-binding fragments [F(ab')2] did not. We also found that F(ab')2 of LJ-Lb1 did not inhibit heparin-induced platelet aggregation but retained inhibitory activity against ristocetin-induced platelet agglutination. The monoclonal antibody 3G6, directed against the alpha-chain of glycoprotein Ib but not inhibitory of ristocetin-induced platelet agglutination, had no effect on heparin-induced platelet aggregation. Antibodies to von Willebrand factor that inhibit ristocetin-induced platelet agglutination did not inhibit heparin-mediated platelet aggregation, but antibodies to glycoprotein IIb-IIIa blocked aggregation. These data suggest that platelet aggregation in heparin-associated thrombocytopenia may be initiated by an interaction between patient IgG, heparin, and the platelet surface. Platelet activation appears to be mediated by a platelet surface crystallizable fragment (Fc) receptor.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of laboratory and clinical medicine AU - Adelman, B AU - Sobel, M AU - Fujimura, Y AU - Ruggeri, Z M AU - Zimmerman, T S AD - Department of Medicine, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA 23249. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 204 EP - 210 VL - 113 IS - 2 SN - 0022-2143, 0022-2143 KW - Immunoglobulin G KW - 0 KW - Platelet Membrane Glycoproteins KW - Receptors, Fc KW - von Willebrand Factor KW - Heparin KW - 9005-49-6 KW - Abridged Index Medicus KW - Index Medicus KW - Platelet Membrane Glycoproteins -- physiology KW - Receptors, Fc -- physiology KW - Humans KW - Platelet Membrane Glycoproteins -- immunology KW - von Willebrand Factor -- physiology KW - Immunoglobulin G -- physiology KW - Heparin -- pharmacology KW - Thrombocytopenia -- chemically induced KW - Platelet Aggregation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78857315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Heparin-associated+thrombocytopenia%3A+observations+on+the+mechanism+of+platelet+aggregation.&rft.au=Adelman%2C+B%3BSobel%2C+M%3BFujimura%2C+Y%3BRuggeri%2C+Z+M%3BZimmerman%2C+T+S&rft.aulast=Adelman&rft.aufirst=B&rft.date=1989-02-01&rft.volume=113&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-21 N1 - Date created - 1989-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of protein kinase-C agonists on parathyroid hormone release and intracellular free Ca2+ in bovine parathyroid cells. AN - 78854970; 2536321 AB - High extracellular Ca2+ stimulates the accumulation of inositol trisphosphate and diacylglycerol in parathyroid cells and suppresses PTH release. Since diacylglycerol is an endogenous activator of protein kinase-C, these observations would suggest that activation of protein kinase-C is associated with inhibition of PTH release. However, phorbol esters, which stimulate protein kinase-C activity, have been reported to enhance PTH release. To clarify the role of protein kinase-C in the regulation of PTH secretion, we studied the responses of parathyroid cells to phorbol myristate acetate (PMA), bryostatin-1, and 1,2-dioctanoylglycerol (diC8). PMA and bryostatin-1 translocated protein kinase-C activity from the soluble to particulate fractions of cell homogenates. Phosphotransferase activity in the particulate fractions increased from 21 +/- 4% to 93 +/- 6% of the total activity after 10 min of exposure to PMA (10(-6) M) and from 21 +/- 2% to 69 +/- 2% after 5 min of exposure to bryostatin-1 (10(-7) M). These three structurally different agonists of protein kinase-C also altered the typical secretory response to Ca2+ in parathyroid cells. At 2.0 mM extracellular Ca2+, PMA (10(-6) M) bryostatin-1 (10(-7) M), and 1,2-dioctanoylglycerol (3 x 10(-4) M) blunted the suppressive effects of high Ca2+ on secretion, thus stimulating PTH release 252 +/- 45%, 122 +/- 20%, and 485 +/- 95% over control levels, respectively. However, at low extracellular Ca2+, these agents inhibited maximal PTH release. Since changes in the intracellular free Ca2+ concentration ([Ca2+]i) may be important in the control of PTH release, we investigated whether protein kinase-C agonists changed the relationship between extracellular Ca2+ and PTH release by affecting [Ca2+]i. In PMA-treated cells, the intracellular Ca2+ response to raising extracellular Ca2+ from 0.5 to 1.5 and 2.0 mM was reduced to 50 +/- 1% and 63 +/- 3% of that in control cells, respectively (P less than 0.005; n = 7-11). Specifically, PMA preincubation reduced the initial intracellular Ca2+ transient with raising extracellular Ca2+ from 0.5 to 2.0 mM and with adding 4.0 mM Sr2+. The sustained phase response to high Ca2+, but not to Sr2+, was also attenuated after incubation with PMA. We conclude that protein kinase-C agonists suppress PTH release at low extracellular Ca2+ and enhance PTH release at high extracellular Ca2+. The effects on secretion at high extracellular Ca2+ may be related to the ability of protein kinase-C agonists to change the sensitivity of [Ca2+]i to high extracellular Ca2+ in these cells. JF - Endocrinology AU - Membreño, L AU - Chen, T H AU - Woodley, S AU - Gagucas, R AU - Shoback, D AD - Endocrine Research Unit, San Francisco Veterans Administration Medical Center, California 94121. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 789 EP - 797 VL - 124 IS - 2 SN - 0013-7227, 0013-7227 KW - Bryostatins KW - 0 KW - Diglycerides KW - Glycerides KW - Lactones KW - Macrolides KW - Parathyroid Hormone KW - 1,2-dioctanoylglycerol KW - 1069-87-0 KW - bryostatin 1 KW - 37O2X55Y9E KW - Phosphotransferases KW - EC 2.7.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cattle KW - Kinetics KW - In Vitro Techniques KW - Intracellular Fluid -- metabolism KW - Phosphotransferases -- metabolism KW - Protein Kinase C -- metabolism KW - Calcium -- metabolism KW - Diglycerides -- pharmacology KW - Parathyroid Hormone -- secretion KW - Parathyroid Glands -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Parathyroid Glands -- drug effects KW - Parathyroid Glands -- secretion KW - Glycerides -- pharmacology KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78854970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+effects+of+protein+kinase-C+agonists+on+parathyroid+hormone+release+and+intracellular+free+Ca2%2B+in+bovine+parathyroid+cells.&rft.au=Membre%C3%B1o%2C+L%3BChen%2C+T+H%3BWoodley%2C+S%3BGagucas%2C+R%3BShoback%2C+D&rft.aulast=Membre%C3%B1o&rft.aufirst=L&rft.date=1989-02-01&rft.volume=124&rft.issue=2&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-07 N1 - Date created - 1989-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Passive smoking affects endothelium and platelets. AN - 78853591; 2916883 AB - Blood was obtained before and after ten healthy male nonsmokers sat for 20 minutes in open hospital corridors beside men who were already there smoking by their own initiative. Mean values before and after passive smoking were 0.87 and 0.78 for the platelet aggregate ratio, 2.8 and 3.7 per counting chamber for the endothelial cell count, 0 and 2.8 ng/mL for the plasma nicotine concentration, and 0.9% and 1.3% for the carboxyhemoglobin level. No variable changed significantly during control periods in which the subjects sat in a room where smoking was prohibited. Passive exposure to tobacco smoke affected the endothelial cell count and platelet aggregate ratio in a manner similar to that previously observed with active smoking. JF - Archives of internal medicine AU - Davis, J W AU - Shelton, L AU - Watanabe, I S AU - Arnold, J AD - Veterans Administration Medical Center, Kansas City, Mo. 64128. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 386 EP - 389 VL - 149 IS - 2 SN - 0003-9926, 0003-9926 KW - Tobacco Smoke Pollution KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Carboxyhemoglobin KW - 9061-29-4 KW - Abridged Index Medicus KW - Index Medicus KW - Carboxyhemoglobin -- analysis KW - Humans KW - Adult KW - Nicotine -- blood KW - Middle Aged KW - Male KW - Endothelium, Vascular -- drug effects KW - Tobacco Smoke Pollution -- adverse effects KW - Platelet Aggregation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78853591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Passive+smoking+affects+endothelium+and+platelets.&rft.au=Davis%2C+J+W%3BShelton%2C+L%3BWatanabe%2C+I+S%3BArnold%2C+J&rft.aulast=Davis&rft.aufirst=J&rft.date=1989-02-01&rft.volume=149&rft.issue=2&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergy of interleukin 1 (IL-1) with arachidonic acid and A23187 in stimulating PGE synthesis in human fibroblasts: IL-1 stimulates fibroblast cyclooxygenase. AN - 78849837; 2492458 AB - The stimulation of prostaglandin E (PGE) synthesis by interleukin 1 (IL-1) has important physiologic effects in many target tissues. The mechanism(s) whereby IL-1 stimulates PGE synthesis is not well understood. Two alternative mechanisms have been postulated: hydrolysis of membrane phospholipid with release of arachidonic acid substrate and induction of cyclooxygenase activity. We examined these mechanisms in IL-1 stimulation of human dermal fibroblast PGE synthesis. IL-1 failed to induce release of previously incorporated radiolabeled arachidonic acid from fibroblasts under conditions where there was a 30-fold or greater stimulation of PGE synthesis. The calcium ionophore, A23187, gave much less stimulation of PGE synthesis while inducing 30-100% release of incorporated [14C]arachidonic acid. There was marked synergy between IL-1 and agents which increased availability of arachidonic acid. For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid. To examine a possible effect of IL-1 on cyclooxygenase synthesis, fibroblast cyclooxygenase was measured by radioimmunoassay. Following treatment with IL-1, fibroblasts demonstrated a two- to threefold increase in content of immunoreactive cyclooxygenase. These results suggest that IL-1 increases fibroblast PGE synthesis by a mechanism(s) other than making available increased membrane arachidonic acid, and that at least part of its effect may be mediated by induction of cyclooxygenase. Furthermore, the effect of IL-1 on fibroblast PGE synthesis is markedly potentiated by agents which increase available substrate. JF - Clinical immunology and immunopathology AU - Korn, J H AU - Downie, E AU - Roth, G J AU - Ho, S Y AD - Division of Rheumatic Diseases, Veterans Administration Medical Center, Newington, Connecticut 06111. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 196 EP - 204 VL - 50 IS - 2 SN - 0090-1229, 0090-1229 KW - Arachidonic Acids KW - 0 KW - Interleukin-1 KW - Arachidonic Acid KW - 27YG812J1I KW - Calcimycin KW - 37H9VM9WZL KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Cell Membrane -- drug effects KW - Humans KW - Cell Membrane -- metabolism KW - Drug Synergism KW - Interleukin-1 -- pharmacology KW - Fibroblasts -- enzymology KW - Dinoprostone -- biosynthesis KW - Calcimycin -- pharmacology KW - Fibroblasts -- metabolism KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Arachidonic Acids -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78849837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+immunology+and+immunopathology&rft.atitle=Synergy+of+interleukin+1+%28IL-1%29+with+arachidonic+acid+and+A23187+in+stimulating+PGE+synthesis+in+human+fibroblasts%3A+IL-1+stimulates+fibroblast+cyclooxygenase.&rft.au=Korn%2C+J+H%3BDownie%2C+E%3BRoth%2C+G+J%3BHo%2C+S+Y&rft.aulast=Korn&rft.aufirst=J&rft.date=1989-02-01&rft.volume=50&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Clinical+immunology+and+immunopathology&rft.issn=00901229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-13 N1 - Date created - 1989-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reducing bone lead content by chelation treatment in chronic lead poisoning: an in vivo X-ray fluorescence and bone biopsy study. AN - 78846768; 2492468 AB - A stained-glass artist with longstanding exposure to lead presented with neuropsychiatric symptoms. He was evaluated before and after chelation treatment by the CaNa2 EDTA lead mobilization test, iliac crest bone lead measurement, and in vivo tibial X-ray fluorescence (XRF). The three methods showed a progressive fall in body lead stores during chelation therapy in association with improvement in symptoms and a fall in blood lead and zinc protoporphyrin levels. In vivo tibial XRF is a safe, rapid, and noninvasive technique for detecting excessive body lead burdens. XRF measurement of bone lead content is a practical method for monitoring the efficacy of therapy as well as for establishing the diagnosis. JF - Environmental research AU - Batuman, V AU - Wedeen, R P AU - Bogden, J D AU - Balestra, D J AU - Jones, K AU - Schidlovsky, G AD - Veterans Administration Medical Center, East Orange, New Jersey 07019. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 70 EP - 75 VL - 48 IS - 1 SN - 0013-9351, 0013-9351 KW - Lead KW - 2P299V784P KW - Edetic Acid KW - 9G34HU7RV0 KW - Index Medicus KW - Spectrometry, X-Ray Emission KW - Humans KW - Middle Aged KW - Biopsy KW - Male KW - Bone and Bones -- analysis KW - Lead Poisoning -- drug therapy KW - Edetic Acid -- therapeutic use KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78846768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Reducing+bone+lead+content+by+chelation+treatment+in+chronic+lead+poisoning%3A+an+in+vivo+X-ray+fluorescence+and+bone+biopsy+study.&rft.au=Batuman%2C+V%3BWedeen%2C+R+P%3BBogden%2C+J+D%3BBalestra%2C+D+J%3BJones%2C+K%3BSchidlovsky%2C+G&rft.aulast=Batuman&rft.aufirst=V&rft.date=1989-02-01&rft.volume=48&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-23 N1 - Date created - 1989-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. AN - 78844822; 2912830 AB - Centrilobular hypoxia mediated by enhanced hepatic consumption of oxygen has been hypothesized to be a factor of pathogenetic importance in ethanol-induced liver injury. In the present study, this hypothesis was tested in a rat model which developed alcoholic centrilobular liver necrosis. Male Wistar rats were infused with high fat diet plus ethanol or isocaloric glucose for 7 weeks, a duration which resulted in induction of balloon cell degeneration, focal necrosis, and inflammation in the centrilobular region of the liver of the ethanol-fed animals. Hepatic blood flow, oxygen consumption and oxygen delivery were determined by the radiolabeled microsphere method and measurement of oxygen content in arterial, portal venous, and hepatic venous blood. Hepatic oxygen consumption was markedly increased by 159% in the ethanol-fed animals compared to that in the controls when results were expressed as relative to body weight. Even after these results were standardized per gram of liver weight, hepatic oxygen consumption was still significantly elevated in the ethanol-fed group, but the magnitude of the elevation was reduced to 70%, due to marked hepatomegaly observed in these animals. There was a concomitant 59% increase in hepatic oxygen delivery in the ethanol-fed rats when expressed per kilogram of body weight, and this effect was attributable entirely to increased portal blood flow. However, the increment of this increase in oxygen delivery was much too small to compensate for the 159% increase in oxygen consumption. In addition, this increase in hepatic oxygen delivery was no longer observable when the results were reexpressed based on the liver weight.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Tsukamoto, H AU - Xi, X P AD - Hepatopancreatic Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 302 EP - 306 VL - 9 IS - 2 SN - 0270-9139, 0270-9139 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Body Weight KW - Animals KW - Necrosis KW - Liver Circulation KW - Oxygen -- blood KW - Hepatic Veins KW - Organ Size KW - Male KW - Liver Diseases, Alcoholic -- metabolism KW - Liver -- pathology KW - Oxygen Consumption KW - Liver Diseases, Alcoholic -- pathology KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78844822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Incomplete+compensation+of+enhanced+hepatic+oxygen+consumption+in+rats+with+alcoholic+centrilobular+liver+necrosis.&rft.au=Tsukamoto%2C+H%3BXi%2C+X+P&rft.aulast=Tsukamoto&rft.aufirst=H&rft.date=1989-02-01&rft.volume=9&rft.issue=2&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-06 N1 - Date created - 1989-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevention of gastroduodenal injury induced by chronic nonsteroidal antiinflammatory drug therapy. AN - 78837530; 2642452 AB - The fact that nonsteroidal antiinflammatory drugs (NSAIDs) damage the gastroduodenal mucosa is now accepted as NSAID use has been associated with a disproportionately high frequency of upper gastrointestinal bleeding and perforation of gastric and duodenal ulcers. More than 10% of patients receiving NSAIDs chronically will have a gastric ulcer on any given day, a point prevalence of ulcer disease 5-10 times higher than in patients who are not taking NSAIDs. Endoscopic studies comparing the effect of acute administration of NSAIDs on the gastroduodenal mucosa in normal volunteers have failed to predict which NSAIDs would be safest when administered chronically. All of the newer NSAIDs appear to be similar in their propensity to cause chronic mucosal damage, including peptic ulceration. Recent studies have suggested that in those starting NSAID therapy, prophylactic cotreatment with H2-receptor antagonists or sucralfate has minimal or no effect on preventing the development of NSAID-induced gastric ulcers, although duodenal ulcers may be reduced. Nonsteroidal antiinflammatory drug-induced gastric ulcers are also not prevented by drug formulations that prevent or markedly reduce the amount of active NSAID in the stomach. Cotreatment with the synthetic prostaglandin misoprostol was associated with a marked reduction in gastric ulcer development in patients with osteoarthritis receiving NSAIDs chronically, suggesting that prevention of prostaglandin generation in the gastric mucosa may play a pivotal role in NSAID-induced gastric ulcers. JF - Gastroenterology AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 675 EP - 681 VL - 96 IS - 2 Pt 2 Suppl SN - 0016-5085, 0016-5085 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Prostaglandins KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Gastroscopy KW - Prostaglandins -- therapeutic use KW - Humans KW - Chronic Disease KW - Duodenal Ulcer -- prevention & control KW - Duodenal Ulcer -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Stomach Ulcer -- prevention & control KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78837530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Prevention+of+gastroduodenal+injury+induced+by+chronic+nonsteroidal+antiinflammatory+drug+therapy.&rft.au=Graham%2C+D+Y&rft.aulast=Graham&rft.aufirst=D&rft.date=1989-02-01&rft.volume=96&rft.issue=2+Pt+2+Suppl&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-07 N1 - Date created - 1989-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of systemic pH on models of altered ileal transport in the rat. AN - 78834696; 2492010 AB - Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were anesthetized and transport was measured in ileal loops during respiratory acidosis and alkalosis. Decreases in arterial pH increased absorption equally in control loops and in adjacent loops perfused with a Ringer's solution containing ST toxin (cyclic guanosine monophosphate-mediated secretion), hypertonic mannitol (passive, osmotically mediated secretion), or glucose. Decreases in arterial pH increased absorption in a similar way in loops exposed to cholera toxin (cyclic adenosine monophosphate-mediated secretion) that were then perfused with glucose-Ringer's solution. Alterations in arterial and luminal pH did not affect glucose absorption. These results suggest that the effect of arterial pH on ileal absorption occurs by a mechanism that is independent of these various means of altering transport. JF - Gastroenterology AU - Charney, A N AU - Ingrassia, P M AU - Thaler, S M AU - Keane, M G AD - Nephrology Section, Veterans Administration Medical Center, New York, New York. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 331 EP - 338 VL - 96 IS - 2 Pt 1 SN - 0016-5085, 0016-5085 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Escherichia coli Proteins KW - heat stable toxin (E coli) KW - Mannitol KW - 3OWL53L36A KW - Hydrogen KW - 7YNJ3PO35Z KW - Cholera Toxin KW - 9012-63-9 KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Glucose -- pharmacology KW - Hydrogen-Ion Concentration KW - Cholera Toxin -- pharmacology KW - Biological Transport KW - Absorption KW - Enterotoxins -- pharmacology KW - Bacterial Toxins -- pharmacology KW - Mannitol -- pharmacology KW - Male KW - Ileum -- secretion KW - Ileum -- metabolism KW - Hydrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78834696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Effect+of+systemic+pH+on+models+of+altered+ileal+transport+in+the+rat.&rft.au=Charney%2C+A+N%3BIngrassia%2C+P+M%3BThaler%2C+S+M%3BKeane%2C+M+G&rft.aulast=Charney&rft.aufirst=A&rft.date=1989-02-01&rft.volume=96&rft.issue=2+Pt+1&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-22 N1 - Date created - 1989-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Impaired oxygenation of gastric mucosa in portal hypertension. The basis for increased susceptibility to injury. AN - 78834295; 2914542 AB - Increased susceptibility to mucosal damage is a prominent feature of portal hypertensive gastropathy. Since the portal hypertensive gastric mucosa has extensive microvascular changes, we postulated that the increased sensitivity to mucosal damage could have an ischemic basis. We measured distribution of gastric serosal and mucosal oxygenation in a group of portal hypertensive and sham-operated rats, and then studied the effects of intragastric aspirin. In the basal state, gastric mucosa of portal hypertensive rats had significantly reduced oxygenation compared to controls (24 +/- 5 vs 45 +/- 7 mm Hg PO2, P less than 0.02), while serosal oxygenation was similar between the two groups. Intragastric aspirin produced significantly greater mucosal damage to portal hypertensive rats and mucosal oxygenation was almost one third that of sham-operated controls. Systemic arterial pressures and oxygenation were similar between the two groups. We conclude that there is impairment of gastric mucosal oxygenation and increased mucosal damage by aspirin in portal hypertensive rats compared with sham-operated controls. These results support our hypothesis that the increased sensitivity of the portal hypertensive mucosa to damage is a consequence of impaired mucosal oxygenation. JF - Digestive diseases and sciences AU - Sarfeh, I J AU - Soliman, H AU - Waxman, K AU - Coccia, M AU - Rypins, E B AU - Bui, H X AU - Tarnawski, A AD - Surgical Service, Long Beach Veterans Administration Medical Center, California. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 225 EP - 228 VL - 34 IS - 2 SN - 0163-2116, 0163-2116 KW - Aspirin KW - R16CO5Y76E KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Male KW - Hypertension, Portal -- pathology KW - Oxygen -- metabolism KW - Oxygen -- blood KW - Aspirin -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- pathology KW - Hypertension, Portal -- blood KW - Hypertension, Portal -- metabolism KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78834295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Impaired+oxygenation+of+gastric+mucosa+in+portal+hypertension.+The+basis+for+increased+susceptibility+to+injury.&rft.au=Sarfeh%2C+I+J%3BSoliman%2C+H%3BWaxman%2C+K%3BCoccia%2C+M%3BRypins%2C+E+B%3BBui%2C+H+X%3BTarnawski%2C+A&rft.aulast=Sarfeh&rft.aufirst=I&rft.date=1989-02-01&rft.volume=34&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - High-dose cisplatin for locally advanced or metastatic head and neck cancer. A phase II pilot study. AN - 78833331; 2912521 AB - High-dose cisplatin (40 mg/m2 every day X5) was administered to 14 patients (11 men, three women) with locally advanced or metastatic head and neck cancer not curable by surgery or refractory to previous chemotherapy and/or radiation therapy. All 14 patients were evaluable for toxicity; one patient was inevaluable for response due to early death. A total of 24 courses of therapy were administered. The dose-limiting toxicity was myelosuppression with 73% of patients experiencing Grade III or IV neutropenia. Grade II or above thrombocytopenia occurred in 30% of the patients. Renal and neurologic toxicity was minimal. Two patients experienced laryngeal edema from vigorous hydration with one of them requiring a tracheostomy for respiratory compromise. Partial responses were seen in six patients (46%). Two of the six patients had received previous treatment with standard dose cisplatin. Two patients achieved long-term responses (54+, 44+ months, respectively). Both of these patients were previously untreated, inoperable (T4N3M0, T3N1M0), and subsequently received radiation therapy after two cycles of chemotherapy. Median duration of response in the remaining responders was 3 months (range, 3-10 months). High-dose cisplatin may benefit selected patients with inoperable, advanced head and neck tumors. However, further randomized trials need to be conducted before firm conclusions can be established. JF - Cancer AU - Havlin, K A AU - Kuhn, J G AU - Myers, J W AU - Ozols, R F AU - Mattox, D E AU - Clark, G M AU - von Hoff, D D AD - Division of Oncology, Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio, TX 78284. Y1 - 1989/02/01/ PY - 1989 DA - 1989 Feb 01 SP - 423 EP - 427 VL - 63 IS - 3 SN - 0008-543X, 0008-543X KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Humans KW - Laryngeal Edema -- pathology KW - Adult KW - Neutropenia -- chemically induced KW - Aged KW - Middle Aged KW - Male KW - Female KW - Head and Neck Neoplasms -- secondary KW - Head and Neck Neoplasms -- pathology KW - Cisplatin -- adverse effects KW - Head and Neck Neoplasms -- drug therapy KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78833331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=High-dose+cisplatin+for+locally+advanced+or+metastatic+head+and+neck+cancer.+A+phase+II+pilot+study.&rft.au=Havlin%2C+K+A%3BKuhn%2C+J+G%3BMyers%2C+J+W%3BOzols%2C+R+F%3BMattox%2C+D+E%3BClark%2C+G+M%3Bvon+Hoff%2C+D+D&rft.aulast=Havlin&rft.aufirst=K&rft.date=1989-02-01&rft.volume=63&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanism of mitogen-induced stimulation of glucose transport in human peripheral blood mononuclear cells. Evidence of an intracellular reserve pool of glucose carriers and their recruitment. AN - 78830871; 2643629 AB - The present study examines the effects of phytohemagglutinin stimulation of a population of human (h) PBMC enriched in lymphocytes (hPBMC) on D-glucose displaceable cytochalasin B binding sites or medium-affinity sites (M-sites) in relation to glucose transport. Previously we have shown that M-sites are glucose transporters in hPBMC (Mookerjee, B.K., et al. 1981. J. Biol. Chem. 256:1290-1300). Equilibrium exchange of 3-O-methyl D-glucose in unstimulated cells revealed two populations with fast and slow flux rates. Phytohemagglutinin stimulates flux rates by converting part of the slow flux population to the fast flux population. M-sites occur in two distinct pools, one in plasma membrane and the other in microsomal fraction. Phytohemagglutinin treatment increases the plasma membrane pool size of M-sites with a concomitant reduction in the microsomal pool size without affecting the binding affinities or the total number of M-sites/cell. Data presented in this paper demonstrate that there are two pools of glucose transporters in these cells and phytohemagglutinin stimulation induces an energy-dependent net translocation of glucose transporters from an intracellular reserve pool to the plasma membrane, which accounts for greater than 60% of the increment in glucose transport. JF - The Journal of clinical investigation AU - Jacobs, D B AU - Lee, T P AU - Jung, C Y AU - Mookerjee, B K AD - Department of Medicine, Veterans Administration Medical Center, Buffalo, New York 14215. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 437 EP - 443 VL - 83 IS - 2 SN - 0021-9738, 0021-9738 KW - Insulin KW - 0 KW - Methylglucosides KW - Monosaccharide Transport Proteins KW - Phytohemagglutinins KW - 3-O-Methylglucose KW - 146-72-5 KW - Cytochalasin B KW - 3CHI920QS7 KW - Potassium Cyanide KW - MQD255M2ZO KW - Abridged Index Medicus KW - Index Medicus KW - Cytochalasin B -- metabolism KW - Methylglucosides -- blood KW - Kinetics KW - Humans KW - Temperature KW - Insulin -- pharmacology KW - Time Factors KW - Phytohemagglutinins -- pharmacology KW - Potassium Cyanide -- pharmacology KW - Neutrophils -- metabolism KW - Monosaccharide Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78830871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Mechanism+of+mitogen-induced+stimulation+of+glucose+transport+in+human+peripheral+blood+mononuclear+cells.+Evidence+of+an+intracellular+reserve+pool+of+glucose+carriers+and+their+recruitment.&rft.au=Jacobs%2C+D+B%3BLee%2C+T+P%3BJung%2C+C+Y%3BMookerjee%2C+B+K&rft.aulast=Jacobs&rft.aufirst=D&rft.date=1989-02-01&rft.volume=83&rft.issue=2&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1982 Jul;79(14):4327-31 [6289300] J Biol Chem. 1981 Jun 25;256(12):6148-54 [6453867] J Immunol. 1983 Sep;131(3):1126-30 [6684138] Biochim Biophys Acta. 1983 Dec 19;763(4):393-407 [6360220] J Biol Chem. 1984 Jul 10;259(13):8125-33 [6376500] J Biol Chem. 1984 Nov 10;259(21):13117-22 [6386808] J Clin Invest. 1984 Nov;74(5):1679-85 [6542109] Eur J Biochem. 1971 Apr 30;19(4):509-13 [5103791] Biochim Biophys Acta. 1969 Apr;173(3):377-88 [5769638] J Biol Chem. 1981 Jun 25;256(12):6400-7 [7016868] J Clin Invest. 1981 Jun;67(6):1636-42 [6787080] J Biol Chem. 1981 Jul 25;256(14):7090-3 [6265437] J Immunol. 1982 May;128(5):2153-9 [7061857] J Biol Chem. 1986 Oct 15;261(29):13606-9 [3531207] Metabolism. 1972 Jul;21(7):619-31 [5040917] J Cell Biol. 1977 Feb;72(2):456-69 [188831] Biochem Soc Trans. 1976;4(6):1120-2 [1022576] J Biol Chem. 1977 Aug 10;252(15):5456-63 [885863] Biochim Biophys Acta. 1977 Nov 7;500(1):89-102 [303526] J Cell Physiol. 1978 Sep;96(3):303-8 [353059] J Biol Chem. 1978 Oct 25;253(20):7289-94 [701251] Biochem J. 1978 Sep 15;174(3):703-9 [310305] Int J Biochem. 1979;10(8):723-31 [499640] Biochem J. 1980 Jan 15;186(1):59-69 [6245642] J Biol Chem. 1980 May 25;255(10):4758-62 [6989818] Proc Natl Acad Sci U S A. 1980 May;77(5):2542-5 [6771756] J Biol Chem. 1981 Feb 10;256(3):1290-300 [7451506] Biochim Biophys Acta. 1983 Apr 21;730(1):49-56 [6338925] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Functional and structural changes in parotid glands of alcoholic cirrhotic patients. AN - 78829485; 2910764 AB - The parotid gland function and structure was studied in 30 patients with biopsy-proven alcoholic cirrhosis and in 43 age- and sex-matched alcoholic and nonalcoholic control subjects. Mean simulated parotid saliva flow rate was significantly (p less than 0.05) lower in patients with alcoholic cirrhosis as compared with alcoholic and nonalcoholic control subjects. A similar reduction was observed in mean basal parotid saliva flow rate in patients with alcoholic cirrhosis that reached statistical significance (p less than 0.05) in comparison with nonalcoholic control subjects. In addition, the concentration of sodium, bicarbonate, and total proteins in stimulated parotid saliva was significantly (p less than 0.005) lower in patients with alcoholic cirrhosis as compared with the two groups of control subjects. Sialograms in 6 patients with alcoholic cirrhosis did not reveal any obstructive lesion in the primary parotid duct or its branches. Histology of salivary tissue revealed an increase in the interstromal fatty infiltration, edema, and fibrosis without evidence of inflammatory reaction in 5 patients as compared with the control subjects. These data provide evidence for marked parotid gland dysfunction in patients with alcoholic cirrhosis presumably due to metabolic derangement and altered parotid gland structure. JF - Gastroenterology AU - Dutta, S K AU - Dukehart, M AU - Narang, A AU - Latham, P S AD - Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 510 EP - 518 VL - 96 IS - 2 Pt 1 SN - 0016-5085, 0016-5085 KW - Electrolytes KW - 0 KW - Salivary Proteins and Peptides KW - Abridged Index Medicus KW - Index Medicus KW - Saliva -- physiology KW - Salivary Proteins and Peptides -- analysis KW - Sialography KW - Hydrogen-Ion Concentration KW - Humans KW - Saliva -- analysis KW - Adult KW - Saliva -- secretion KW - Aged KW - Middle Aged KW - Electrolytes -- analysis KW - Male KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Parotid Gland -- pathology KW - Liver Cirrhosis, Alcoholic -- pathology KW - Parotid Gland -- secretion KW - Parotid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78829485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Functional+and+structural+changes+in+parotid+glands+of+alcoholic+cirrhotic+patients.&rft.au=Dutta%2C+S+K%3BDukehart%2C+M%3BNarang%2C+A%3BLatham%2C+P+S&rft.aulast=Dutta&rft.aufirst=S&rft.date=1989-02-01&rft.volume=96&rft.issue=2+Pt+1&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-22 N1 - Date created - 1989-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ulcers, nonsteroidal antiinflammatory drugs, and related matters. AN - 78824839; 2642443 AB - This overview is intended to provide perspectives drawn from the proceedings of the Ulcer-Epidemiology Symposium reported in this supplement. This meeting was designed to review the epidemiology and risk factors underlying the development of acid/peptic diseases and to highlight the natural history and therapy of these disorders. These topics served as a focus for the meeting. A second goal was to consider the topics in the context of ulcer complications resulting from use of nonsteroidal antiinflammatory drugs. Although nonsteroidal antiinflammatory drugs are well known to cause gastric damage and ulcers and to lead to complications of preexisting peptic ulcers, the frequency and severity of the clinical problems resulting from their use and the efficacy of different modalities for prevention and treatment have only recently begun to be the subjects of careful analysis. JF - Gastroenterology AU - Soll, A H AU - Kurata, J AU - McGuigan, J E AD - Center for Ulcer Research and Education, Veterans Administration Wadsworth Hospital Center, Los Angeles, California. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 561 EP - 568 VL - 96 IS - 2 Pt 2 Suppl SN - 0016-5085, 0016-5085 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Prostaglandins KW - Abridged Index Medicus KW - Index Medicus KW - Prostaglandins -- therapeutic use KW - Risk Factors KW - Humans KW - Duodenal Ulcer -- prevention & control KW - Duodenal Ulcer -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Stomach Ulcer -- prevention & control KW - Duodenal Ulcer -- complications KW - Stomach Ulcer -- complications KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78824839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Ulcers%2C+nonsteroidal+antiinflammatory+drugs%2C+and+related+matters.&rft.au=Soll%2C+A+H%3BKurata%2C+J%3BMcGuigan%2C+J+E&rft.aulast=Soll&rft.aufirst=A&rft.date=1989-02-01&rft.volume=96&rft.issue=2+Pt+2+Suppl&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-07 N1 - Date created - 1989-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report. AN - 78844090; 2913777 AB - The effects of prazosin therapy were recently evaluated in ambulatory patients with essential hypertension and chronic obstructive pulmonary disease. Both the ability of prazosin to control high blood pressure and its effects on pulmonary function were observed. Systolic and diastolic blood pressures were significantly reduced at the end of the maintenance period. Of the 17 patients completing the trial, 82.4 percent attained a target diastolic blood pressure of less than 90 mm Hg, and 70.6 percent attained a diastolic reduction of greater than 10 mm Hg. Results of six-hour pulmonary function tests showed no significant differences after dosing with placebo or with prazosin. There was a significant increase in the number of patients who noted increased wheezing, but these patients did not have any increase in cough or sputum symptoms. JF - The American journal of medicine AU - Chodosh, S AU - Tuck, J AU - Pizzuto, D AD - Pulmonary Clinic, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108. Y1 - 1989/01/23/ PY - 1989 DA - 1989 Jan 23 SP - 91 EP - 93 VL - 86 IS - 1B SN - 0002-9343, 0002-9343 KW - Prazosin KW - XM03YJ541D KW - Abridged Index Medicus KW - Index Medicus KW - Maximal Midexpiratory Flow Rate KW - Vital Capacity KW - Humans KW - Chronic Disease KW - Blood Pressure -- drug effects KW - Forced Expiratory Volume KW - Prazosin -- adverse effects KW - Hypertension -- complications KW - Bronchitis -- complications KW - Hypertension -- physiopathology KW - Bronchitis -- physiopathology KW - Lung -- physiopathology KW - Prazosin -- therapeutic use KW - Asthma -- physiopathology KW - Hypertension -- drug therapy KW - Asthma -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78844090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Prazosin+in+hypertensive+patients+with+chronic+bronchitis+and+asthma%3A+a+brief+report.&rft.au=Chodosh%2C+S%3BTuck%2C+J%3BPizzuto%2C+D&rft.aulast=Chodosh&rft.aufirst=S&rft.date=1989-01-23&rft.volume=86&rft.issue=1B&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mild hypertension in the elderly. A comparison of prazosin and enalapril. AN - 78833932; 2536516 AB - In a single-blind, crossover study, prazosin and enalapril monotherapies were evaluated in 15 patients, aged 55 years or older (average age, 64 years), with mild hypertension (sitting diastolic blood pressure between 90 and 104 mm Hg). After eight weeks of placebo administration, patients were randomly assigned to treatment with prazosin or enalapril and then treated with the alternate drug after a second eight-week placebo washout period. The dose was titrated from 1 mg to a maximum of 10 mg twice daily of prazosin and from 2.5 mg to a maximum of 20 mg twice daily of enalapril to achieve a reduction in diastolic blood pressure to less than 85 mm Hg, with a decrease of at least 10 mm Hg based on clinical measurements of blood pressure. Patients received maintenance therapy with each medication for at least eight weeks. The response to therapy was then evaluated with two-hour periods of automated blood pressure monitoring. Average systolic and diastolic blood pressures for all patients during these two-hour monitoring periods decreased by 10.3 +/- 1.9/8.3 +/- 1.5 mm Hg during prazosin therapy and by 9.0 +/- 5.1/5.8 +/- 3.4 mm Hg during enalapril therapy. All patients responded to one of the two drugs, but only 50 percent responded to both. Side effects were generally mild and transient, and no significant metabolic effects were observed. Both prazosin and enalapril were effective and well tolerated in this population of elderly patients with mild hypertension. JF - The American journal of medicine AU - Cheung, D G AU - Hoffman, C A AU - Ricci, S T AU - Weber, M A AD - Hypertension Center, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1989/01/23/ PY - 1989 DA - 1989 Jan 23 SP - 87 EP - 90 VL - 86 IS - 1B SN - 0002-9343, 0002-9343 KW - Enalapril KW - 69PN84IO1A KW - Prazosin KW - XM03YJ541D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Prazosin -- adverse effects KW - Hypertension -- physiopathology KW - Enalapril -- therapeutic use KW - Prazosin -- therapeutic use KW - Enalapril -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78833932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Mild+hypertension+in+the+elderly.+A+comparison+of+prazosin+and+enalapril.&rft.au=Cheung%2C+D+G%3BHoffman%2C+C+A%3BRicci%2C+S+T%3BWeber%2C+M+A&rft.aulast=Cheung&rft.aufirst=D&rft.date=1989-01-23&rft.volume=86&rft.issue=1B&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rate. AN - 78893686; 2564802 AB - Glycinergic mechanisms have been implicated in central cardiovascular regulation. However, the inhibitory amino acid's role in the nucleus tractus solitarii (NTS), the site of termination of cardiovascular afferents, has not been clarified. Thus, we sought to determine if the microinjection of glycine into the NTS alters arterial pressure and heart rate. Microinjections of glycine, like glutamate, confined to the NTS decreased arterial pressure and heart rate in a neurally mediated, dose-dependent manner. The glycine antagonist strychnine completely blocked these effects of glycine but did not itself alter arterial pressure or heart rate, or interfere with the baroreceptor reflex. The acute hypotensive, bradycardic response to glycine was followed by a period during which glycine essentially eliminated the cardiovascular responses to the microinjection into the NTS of glutamate, an amino acid reputed to be a transmitter in the baroreceptor reflex arc. These data suggest that glycine is involved in cardiovascular regulation by the NTS but do not support its being an integral transmitter in the baroreceptor reflex. JF - Brain research AU - Talman, W T AU - Robertson, S C AD - Department of Neurology, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1989/01/16/ PY - 1989 DA - 1989 Jan 16 SP - 7 EP - 13 VL - 477 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Glutamates KW - 0 KW - Phenylephrine KW - 1WS297W6MV KW - Glutamic Acid KW - 3KX376GY7L KW - Propranolol KW - 9Y8NXQ24VQ KW - Strychnine KW - H9Y79VD43J KW - Chlorisondamine KW - JD3M24F66I KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Reference Values KW - Propranolol -- pharmacology KW - Pressoreceptors -- physiology KW - Microinjections KW - Pressoreceptors -- drug effects KW - Chlorisondamine -- pharmacology KW - Rats KW - Rats, Inbred Strains KW - Strychnine -- pharmacology KW - Male KW - Phenylephrine -- pharmacology KW - Heart Rate -- drug effects KW - Medulla Oblongata -- physiology KW - Glutamates -- administration & dosage KW - Glycine -- pharmacology KW - Glutamates -- pharmacology KW - Blood Pressure -- drug effects KW - Medulla Oblongata -- drug effects KW - Glycine -- antagonists & inhibitors KW - Glycine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78893686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Glycine%2C+like+glutamate%2C+microinjected+into+the+nucleus+tractus+solitarii+of+rat+decreases+arterial+pressure+and+heart+rate.&rft.au=Talman%2C+W+T%3BRobertson%2C+S+C&rft.aulast=Talman&rft.aufirst=W&rft.date=1989-01-16&rft.volume=477&rft.issue=1-2&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-19 N1 - Date created - 1989-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recovery of ethanol-induced impairments in receptor-mediated endocytosis of asialoorosomucoid in isolated rat hepatocytes. AN - 79315381; 3269099 JF - Transactions of the American Clinical and Climatological Association AU - Sorrell, M F AU - Casey, C A AU - Tuma, D J AD - Liver Study Unit, Veterans Administration Medical Center, Omaha, Nebraska 68105. Y1 - 1989 PY - 1989 DA - 1989 SP - 163 EP - 170 VL - 100 SN - 0065-7778, 0065-7778 KW - Asialoglycoprotein Receptor KW - 0 KW - Asialoglycoproteins KW - Orosomucoid KW - Receptors, Immunologic KW - asialoorosomucoid KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Liver -- drug effects KW - Receptors, Immunologic -- metabolism KW - Orosomucoid -- metabolism KW - In Vitro Techniques KW - Liver -- metabolism KW - Male KW - Endocytosis -- drug effects KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79315381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.atitle=Recovery+of+ethanol-induced+impairments+in+receptor-mediated+endocytosis+of+asialoorosomucoid+in+isolated+rat+hepatocytes.&rft.au=Sorrell%2C+M+F%3BCasey%2C+C+A%3BTuma%2C+D+J&rft.aulast=Sorrell&rft.aufirst=M&rft.date=1989-01-01&rft.volume=100&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.issn=00657778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-12 N1 - Date created - 1989-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Enzymol Relat Areas Mol Biol. 1974;41(0):99-128 [4609051] Proc Natl Acad Sci U S A. 1981 Mar;78(3):1557-61 [6262814] J Biol Chem. 1982 Feb 10;257(3):1201-7 [6276377] Annu Rev Biochem. 1982;51:531-54 [6287920] J Biol Chem. 1987 Feb 25;262(6):2704-10 [3818618] Biochem Biophys Res Commun. 1984 Sep 28;123(3):951-8 [6487336] Gastroenterology. 1986 Jan;90(1):158-65 [3940242] Biochim Biophys Acta. 1986 Apr 25;856(3):571-7 [3964697] Alcohol Clin Exp Res. 1982 Fall;6(4):523-31 [6758624] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The impact of cell culture sensitivity on rapid viral diagnosis: a historical perspective. AN - 20305733; 8928696 AB - The contribution of cell culture systems in the diagnosis of viral infections has been well recognized over the years. Not only did such systems make possible the direct isolation and identification of viruses, but also the production of viral diagnostic reagents for rapid diagnosis, the evaluation of antiviral agents, and the production of vaccines for the control of viral diseases. Although many reagents for rapid detection of viral antigens/genomes are currently available, none will make possible discoveries of new viral agents. Thus sensitive cell culture systems are still essential for the rapid and accurate diagnosis of viral infections. Since, as yet, no single cell culture system is susceptible to all viruses, the constant search for additional sensitive cell culture systems for detecting those unknown and/or currently non-cultivable viral agents continues to be an open area of investigation in the field of diagnostic virology. Images FIG. 1 FIG. 3 JF - Yale Journal of Biology and Medicine AU - Hsiung, G D AD - Virology Reference Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516. Y1 - 1989 PY - 1989 DA - 1989 SP - 79 EP - 88 PB - Yale Journal of Biology and Medicine, Inc., 333 Cedar St, PO Box 208000 VL - 62 IS - 2 SN - 0044-0086, 0044-0086 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Antiviral agents KW - Cell culture KW - Vaccines KW - Infection KW - G 07800:Plants and Algae KW - V 22340:Antiviral Agents KW - W 30915:Pharmaceuticals & Vaccines KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20305733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Yale+Journal+of+Biology+and+Medicine&rft.atitle=The+impact+of+cell+culture+sensitivity+on+rapid+viral+diagnosis%3A+a+historical+perspective.&rft.au=Hsiung%2C+G+D&rft.aulast=Hsiung&rft.aufirst=G&rft.date=1989-01-01&rft.volume=62&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Yale+Journal+of+Biology+and+Medicine&rft.issn=00440086&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Antiviral agents; Cell culture; Vaccines; Infection ER -