TY - JOUR T1 - Revised Administration and Scoring Procedures for the Boston Naming Test and Norms for Non-Brain-Damaged Adults AN - 85508391; 8908881 AB - Standard administration, response coding, & scoring procedures were developed for the 60-item Boston Naming Test (BNT). Standard prompts to be given following certain types of incorrect responses were also developed. The BNT was administered to non-brain-damaged adults (N = 60) using these standard procedures. Results show that examiners can reliably carry out the revised test procedures. Results also show that two response categories (related name & don't know) accounted for nearly 80% of incorrect responses. Several BNT test pictures frequently elicited a consistent name other than the one specified in the test. Prompting for an additional response following related name & multiple attempts responses frequently elicited the correct BNT name. Prompts following other types of error responses usually did not elicit the correct name. Neither the age nor education of the non-brain-damaged Ss was strongly related to their total BNT score. 6 Tables, 3 References. HA JF - Aphasiology AU - Nicholas, Linda E AU - Brookshire, Robert H AU - MacLennan, Donald L AU - Schumacher, James G AU - Porrazzo, Shirley A AD - Speech Pathology Service-127A Veterans Administration Medical Center, Minneapolis MN 55417 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 569 EP - 580 VL - 3 IS - 6 SN - 0268-7038, 0268-7038 KW - Boston Naming Test, revised administration/scoring procedures, non-brain-damaged adults KW - Language Pathology (la4) KW - Testing (te7) KW - Aphasia (ap1) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85508391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Revised+Administration+and+Scoring+Procedures+for+the+Boston+Naming+Test+and+Norms+for+Non-Brain-Damaged+Adults&rft.au=Nicholas%2C+Linda+E%3BBrookshire%2C+Robert+H%3BMacLennan%2C+Donald+L%3BSchumacher%2C+James+G%3BPorrazzo%2C+Shirley+A&rft.aulast=Nicholas&rft.aufirst=Linda&rft.date=1989-01-01&rft.volume=3&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Testing (te7); Language Pathology (la4); Aphasia (ap1) ER - TY - JOUR T1 - Alexia and Agraphia after Luria AN - 85339869; llba-9004768 AB - A. R. Luria investigated the acquisition of reading & writing in children, tracing the emergence of these abilities through several stages. In addition to his interest in the ontogeny & anthropology of these skills, Luria applied his neurodynamic approach to examination of the breakdown of these same skills in brain-damaged adults. He described five types of agraphias & eight types of alexias. Each alexic & agraphic syndrome is clinically distinguishable on the basis of a unique pattern of disrupted & preserved skills. Restoration of reading & writing is accomplished according to syndrome-specific strategies. It is shown that Luria's approach foreshadowed many contemporary theories of both alexia & agraphia, as in the description of hierarchical stages of development, discussion of reading abnormalities associated with frontal lobe lesions, & design of syndrome-specific treatment strategies. 23 References. Modified HA JF - Journal of Neurolinguistics AU - Cummings, Jeffrey L AU - von Lanker, Diana Roupas AD - Veterans Administration Medical Center West Los Angeles, Wilshire & Sawtelle Blvds CA 90073 Y1 - 1989 PY - 1989 DA - 1989 SP - 95 EP - 111 VL - 4 IS - 1 SN - 0911-6044, 0911-6044 KW - reading/writing disorders, brain-damaged adults, A. R. Luria's neurodynamic approach application KW - *Reading Deficiency (re3) KW - *Language Pathology (la4) KW - *Writing Disorders (wr1) KW - *History of Linguistics (hi1) KW - article KW - 4810: history of linguistics; history of linguistics KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85339869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=Alexia+and+Agraphia+after+Luria&rft.au=Cummings%2C+Jeffrey+L%3Bvon+Lanker%2C+Diana+Roupas&rft.aulast=Cummings&rft.aufirst=Jeffrey&rft.date=1989-01-01&rft.volume=4&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Language Pathology (la4); *History of Linguistics (hi1); *Reading Deficiency (re3); *Writing Disorders (wr1) ER - TY - JOUR T1 - The Course of Chronic Aphasia AN - 85331977; llba-8903986 AB - Little is known about the long-term recovery or stability of aphasia following brain injury. Stroke patients (N = 35 Ms) were studied repeatedly from 3 to 55 months postonset with the Porch Index of Communicative Ability (PICA) to follow improvement in each of five previously extracted factors (speaking, writing, comprehension, gesturing, & copying) across the five-year span. Patients were grouped into one of four categories based on a previous analysis of 118 patients. PICA overall score increased over the first year, became asymptotic in the second year, & either remained level or declined in the third & fourth years postonset. Lang factors showed differential changes with the greatest improvement in speaking. Different categories of patients showed different patterns of change over time. Ten patients had greater than an 11% PICA overall decline beyond the second year. They were among those with the mildest aphasias. Reasons for decline included change in health status, increasing dementia, & depression. It is demonstrated that many aphasia patients who receive treatment continue to improve in most modalities up to two years postonset, after which some patients decline & others stabilize. 2 Tables, 4 Figures, 19 References. HA JF - Aphasiology AU - Hanson, Wayne R AU - Metter, E Jeffrey AU - Riege, Walter H AD - Veterans Administration Medical Center, 16111 Plummer St Sepulveda CA 91343 Y1 - 1989/01// PY - 1989 DA - Jan 1989 SP - 19 EP - 29 VL - 3 IS - 1 SN - 0268-7038, 0268-7038 KW - aphasia following brain injury, long-term recovery/stability examined KW - Porch Index of Communicative Ability KW - male stroke patients KW - *Language Therapy (la7a) KW - *Language Pathology (la4) KW - *Speech Testing (sp12) KW - *Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85331977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+Course+of+Chronic+Aphasia&rft.au=Hanson%2C+Wayne+R%3BMetter%2C+E+Jeffrey%3BRiege%2C+Walter+H&rft.aulast=Hanson&rft.aufirst=Wayne&rft.date=1989-01-01&rft.volume=3&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (ap1); *Language Pathology (la4); *Language Therapy (la7a); *Speech Testing (sp12) ER - TY - JOUR T1 - Rating Communication Behaviours in the Head-Injured Adult AN - 85290167; llba-8906412 AB - Evaluation of certain communication skills in head-injured adults has generally been limited to informal clinical impressions. A rating scale has been developed that addresses several of these communication abilities in a behaviorally based model. Preliminary data from a sample of head-injured adults & trained raters (N = 4 each) revealed robust inter- & intrarater reliability. Statistical relationships between the scale & three linguistic measures for a group of head-injured adults (N = 20) were addressed with negative results. Individually the items selected appear to quantify aspects of complex communication behavior. 13 References. HA JF - Brain Injury AU - Ehrlich, Jonathan AU - Barry, Philip AD - Brooklyn Veterans Administration Medical Center, 800 Poly Pl NY 11209 PY - 1989 SP - 193 EP - 198 VL - 3 IS - 2 SN - 0269-9052, 0269-9052 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85290167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Injury&rft.atitle=Rating+Communication+Behaviours+in+the+Head-Injured+Adult&rft.au=Ehrlich%2C+Jonathan%3BBarry%2C+Philip&rft.aulast=Ehrlich&rft.aufirst=Jonathan&rft.date=1989-01-01&rft.volume=3&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Brain+Injury&rft.issn=02699052&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Transmission of sound generated by sternal percussion. AN - 85283057; pmid-2917930 AB - We indirectly determined the transmission path of sound generated by sternal percussion in five healthy subjects. We percussed the sternum of each subject while recording the output audio signal at the posterior left and right upper and lower lung zones. Sound measurements were done during apnea at functional residual capacity, total lung capacity, and residual volume both with the lungs filled with air and with an 80% He-20% O2 (heliox) gas mixture. Three acoustic indexes were calculated from the output sound pulse: the peak-to-peak amplitude, the peak frequency, and the mid-power frequency. We found that the average values of all indexes tended to be greater in the upper than in the ipsilateral lower lung zones. In the upper zones, peak-to-peak amplitude was greater at total lung capacity and residual volume than at functional residual capacity. Replacing air with heliox did not change these results. These experiments, together with others performed during Mueller and Valsalva maneuvers, suggest that resonance of the chest cage is the predominant factor determining the transmission of sternal percussion sounds to the posterior chest wall. The transmission seems to be only minimally affected by the acoustic characteristics of the lung parenchyma. JF - Journal of Applied Physiology (Bethesda, Md. : 1985) AU - Bohadana, A B AU - Kraman, S S AD - Veterans Administration Medical Center, Lexington, Kentucky. PY - 1989 SP - 273 EP - 277 VL - 66 IS - 1 SN - 8750-7587, 8750-7587 KW - Residual Volume KW - Human KW - Adult KW - Thorax KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Total Lung Capacity KW - Male KW - Percussion KW - Sound KW - Sternum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85283057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Transmission+of+sound+generated+by+sternal+percussion.&rft.au=Bohadana%2C+A+B%3BKraman%2C+S+S&rft.aulast=Bohadana&rft.aufirst=A&rft.date=1989-01-01&rft.volume=66&rft.issue=1&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Transmission to the chest of sound introduced at the mouth. AN - 85280822; pmid-2917931 AB - We examined the transmission to the chest wall of white noise and 25-Hz square-wave-generated noise introduced at the mouth of five healthy subjects. The output audio signals were recorded over the left and right upper and lower lung zones, posteriorly. Sound measurements were made during apnea at functional residual capacity, total lung capacity, and residual volume both after breathing air and an 80% He-20% O2 (heliox) gas mixture. We calculated the peak-to-peak amplitude, the peak frequency, and the midpower frequency of the output sound. We found no consistent variations in the values of these indexes due to lung volume or resident gas density. In all cases, the transmitted sound was most intense at the right upper zone. This could not be explained on the basis of technical factors but was probably the result of normal asymmetry of the mediastinal anatomy. These data suggest that sound introduced through the mouth of healthy individuals excites intrathoracic structures but is transmitted through the parenchyma in such a manner that it is not markedly affected by familiar physiological variables. This must be taken into account if objective acoustical tests of lung physiology are to be developed. JF - Journal of Applied Physiology (Bethesda, Md. : 1985) AU - Kraman, S S AU - Bohadana, A B AD - Veterans Administration Medical Center, Lexington, Kentucky. PY - 1989 SP - 278 EP - 281 VL - 66 IS - 1 SN - 8750-7587, 8750-7587 KW - Oxygen KW - Respiratory Physiology KW - Respiration KW - Human KW - Adult KW - Thorax KW - Support, U.S. Gov't, Non-P.H.S. KW - Support, Non-U.S. Gov't KW - Helium KW - Air KW - Mouth KW - Male KW - Sound UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85280822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Transmission+to+the+chest+of+sound+introduced+at+the+mouth.&rft.au=Kraman%2C+S+S%3BBohadana%2C+A+B&rft.aulast=Kraman&rft.aufirst=S&rft.date=1989-01-01&rft.volume=66&rft.issue=1&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Bereitschaftspotential in tardive dyskinesia. AN - 85277074; pmid-2733704 AB - The bereitschaftspotential or motor readiness potential is a slow negative electroencephalographic wave occurring 150-1500 ms prior to the onset of a voluntary movement. It was measured in 33 subjects: 11 normal controls, 11 medicated schizophrenics with no tardive dyskinesia or evidence of drug-induced parkinsonism, and 11 patients with tardive dyskinesia. The bereitschaftspotential amplitude was more than two times larger in patients with tardive dyskinesia than in normal controls or schizophrenic patients without tardive dyskinesia. The increased amplitude correlated with the degree of severity of the tardive dyskinesia as measured on the Abnormal Involuntary Movement Scale (AIMS). The finding of the increased bereitschaftspotential amplitude in tardive dyskinesia, taken together with earlier findings of low amplitude in Parkinson's disease, suggests that this potential may reflect the level of dopaminergic activity in the basal ganglia. JF - Movement Disorders AU - Adler, L E AU - Pecevich, M AU - Nagamoto, H AD - Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado. PY - 1989 SP - 105 EP - 112 VL - 4 IS - 2 SN - 0885-3185, 0885-3185 KW - Support, U.S. Gov't, P.H.S. KW - Dyskinesia, Drug-Induced KW - Arousal KW - Human KW - Muscles KW - Electromyography KW - Dominance, Cerebral KW - Basal Ganglia KW - Schizophrenia KW - Cerebral Cortex KW - Evoked Potentials KW - Adult KW - Receptors, Dopamine KW - Support, U.S. Gov't, Non-P.H.S. KW - Afferent Pathways KW - Contingent Negative Variation KW - Attention KW - Female KW - Male KW - Electroencephalography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85277074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+Disorders&rft.atitle=Bereitschaftspotential+in+tardive+dyskinesia.&rft.au=Adler%2C+L+E%3BPecevich%2C+M%3BNagamoto%2C+H&rft.aulast=Adler&rft.aufirst=L&rft.date=1989-01-01&rft.volume=4&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Movement+Disorders&rft.issn=08853185&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Acute gastrointestinal bleeding in anticoagulated patients: a prospective evaluation. AN - 85226726; pmid-2783528 AB - Acute gastrointestinal hemorrhage is one of the most feared complications of anticoagulation therapy. We prospectively evaluated 18 episodes of acute gastrointestinal bleeding in 17 patients anticoagulated with coumadin or heparin. Endoscopic examination revealed significant lesions irrespective of age, duration of anticoagulation, level of anticoagulation or symptoms. The high frequency of objective findings (e.g., 44% ulcers) suggests that diagnostic endoscopy should be performed in patients with acute gastrointestinal bleeding associated with anticoagulant therapy. JF - The American Journal of Gastroenterology AU - Tabibian, N AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. PY - 1989 SP - 10 EP - 12 VL - 84 IS - 1 SN - 0002-9270, 0002-9270 KW - Acute Disease KW - Prospective Studies KW - Aged, 80 and over KW - Human KW - Adult KW - Gastrointestinal Hemorrhage KW - Aged KW - Middle Age KW - Warfarin KW - Heparin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Acute+gastrointestinal+bleeding+in+anticoagulated+patients%3A+a+prospective+evaluation.&rft.au=Tabibian%2C+N&rft.aulast=Tabibian&rft.aufirst=N&rft.date=1989-01-01&rft.volume=84&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The ileum is the major site of absorption of vitamin B12 analogues. AN - 85223629; pmid-2912026 AB - Non-cobalamin vitamin B12 analogues constitute a significant percentage of total corrinoids in human serum. The source and means of absorption of analogues and their significance are largely unknown. We studied the sites of production and absorption of B12 analogues by measuring serum vitamin B12 and analogues in 93 patients with various gastrointestinal diseases: pernicious anemia (PA), ileal resections, ileitis, Crohn's colitis, ulcerative colitis, and irritable bowel syndrome (IBS). Patients with PA had normal analogue levels that were unchanged or that rose during cessation of B12 administration. Patients with IBS, Crohn's colitis, ulcerative colitis, and total colectomies had B12 analogues in the normal range. Patients with diseased or resected ileums had low B12 and analogues. These data suggest that serum B12 analogues are absorbed in the ileum by a mechanism independent of intrinsic factor, and that colonic bacteria and endogenous metabolism of vitamin B12 do not contribute significantly to their level. JF - The American Journal of Gastroenterology AU - Shaw, S AU - Jayatilleke, E AU - Meyers, S AU - Colman, N AU - Herzlich, B AU - Herbert, V AD - Bronx Veterans Administration Medical Center, New York. PY - 1989 SP - 22 EP - 26 VL - 84 IS - 1 SN - 0002-9270, 0002-9270 KW - Anemia, Pernicious KW - Support, U.S. Gov't, P.H.S. KW - Gastrointestinal Diseases KW - Ileitis KW - Human KW - Support, U.S. Gov't, Non-P.H.S. KW - Vitamin B 12 KW - Antibiotics KW - Ileum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=The+ileum+is+the+major+site+of+absorption+of+vitamin+B12+analogues.&rft.au=Shaw%2C+S%3BJayatilleke%2C+E%3BMeyers%2C+S%3BColman%2C+N%3BHerzlich%2C+B%3BHerbert%2C+V&rft.aulast=Shaw&rft.aufirst=S&rft.date=1989-01-01&rft.volume=84&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Long-term follow-up of chemotherapy in advanced head and neck cancer. AN - 85222428; pmid-2462437 AB - We treated 94 patients with advanced head and neck cancer with a combined-modality protocol that included induction chemotherapy followed by surgery with and without radiotherapy. With a minimum follow-up of 3 1/2 years, 33 (35%) of the patients were alive and disease free. Thirty (32%) of the patients died of recurrent head and neck cancer. Complete response to chemotherapy and initial tumor bulk correlated with prolonged disease-free survival. Site of disease had no effect. There appeared to be no advantage to the use of routine postoperative radiotherapy in these advanced tumors. JF - Archives of Otolaryngology--Head and Neck Surgery AU - Spaulding, M B AU - Loré J M AU - Sundquist, N AD - Oncology Section, Veterans Administration Medical Center, Buffalo, NY 14215. PY - 1989 SP - 68 EP - 73 VL - 115 IS - 1 SN - 0886-4470, 0886-4470 KW - Postoperative Care KW - Combined Modality Therapy KW - Humans KW - Vincristine KW - Pilot Projects KW - Bleomycin KW - Cisplatin KW - Head and Neck Neoplasms KW - Antineoplastic Combined Chemotherapy Protocols KW - Follow-Up Studies KW - Carcinoma, Squamous Cell KW - Time Factors KW - Male KW - Female KW - Clinical Protocols UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85222428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Long-term+follow-up+of+chemotherapy+in+advanced+head+and+neck+cancer.&rft.au=Spaulding%2C+M+B%3BLor%C3%A9+J+M%3BSundquist%2C+N&rft.aulast=Spaulding&rft.aufirst=M&rft.date=1989-01-01&rft.volume=115&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.issn=08864470&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Comparative anatomy of melanin pigment in the stria vascularis. Evidence for a distinction between melanocytes and intermediate cells in the cat. AN - 85165040; pmid-2929316 AB - Although Corti in 1851 first described the presence of cochlear pigmentation in the stria vascularis (SV) of "very old" cats, modern studies have failed to find pigment consistently in the feline stria. While the variable presence of pigment in the feline SV would appear to contrast with this structure's uniform pigmentation in other mammalian species, variability in both the distribution and abundance of inner ear pigment has rarely been studied in any species. In the present study, the SV was examined light microscopically in sectioned material or whole-mounts from pigmented and albino animals of 5 species, including the cat, guinea pig, rabbit, ferret and mouse. In these species, the SV of each pigmented animal contained varying amounts of melanin pigment and none was found in the albino inner ear. Pigmented guinea pigs contained the most uniformly dense and least variable distribution of strial melanin, followed by the rabbit, mouse, ferret and cat. Several species also displayed more strial pigment apically and less basally. In cats, pigmented cells were principally located adjacent to the strial capillaries. Ultrastructural studies of the stria in pigmented cats revealed that these perivascular cells frequently contained an abundance of pigmented organelles and other structural features which allowed them to be distinguished from intermediate cells. JF - Acta Oto-Laryngologica AU - Conlee, J W AU - Parks, T N AU - Schwartz, I R AU - Creel, D J AD - Veterans Administration Medical Center, Salt Lake City, Utah. PY - 1989 SP - 48 EP - 58 VL - 107 IS - 1-2 SN - 0001-6489, 0001-6489 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85165040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Oto-Laryngologica&rft.atitle=Comparative+anatomy+of+melanin+pigment+in+the+stria+vascularis.+Evidence+for+a+distinction+between+melanocytes+and+intermediate+cells+in+the+cat.&rft.au=Conlee%2C+J+W%3BParks%2C+T+N%3BSchwartz%2C+I+R%3BCreel%2C+D+J&rft.aulast=Conlee&rft.aufirst=J&rft.date=1989-01-01&rft.volume=107&rft.issue=1-2&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Acta+Oto-Laryngologica&rft.issn=00016489&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Memory impairments in alcoholism: effects of age and education. AN - 79578317; 2485289 AB - Memory impairments related to alcoholism and to age (young, middle, and old) were examined as a function of educational level (low, high). Factoring of 14 different memory test scores from 93 alcoholics and 73 controls into four components indicated that alcohol-related impairments in verbal memory were observed in adults with low, but not high levels of education. Similarly, age-related decrements in visual-spatial and verbal memory tasks (Components I and II) affected mainly low-education alcoholics and controls. On these components, age and alcoholism did not interact, but were additive. Effects of education were reflected in verbal but not nonverbal tasks (Auditory and Design Recognition, Components III and IV). Neither years of heavy drinking, lifetime consumption, nor abstinence (80% had < 7 wks abstinence) predicted component scores of alcoholics, while age or education accounted for significant variance in visual-spatial, verbal, and design recognition components. JF - Journal of substance abuse AU - Harker, J O AU - Riege, W H AD - Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1989 PY - 1989 DA - 1989 SP - 417 EP - 430 VL - 1 IS - 4 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Age Factors KW - Humans KW - Adult KW - Verbal Learning -- drug effects KW - Alcohol Drinking -- adverse effects KW - Aged KW - Middle Aged KW - Neuropsychological Tests KW - Alcoholism -- psychology KW - Male KW - Alcohol Amnestic Disorder -- rehabilitation KW - Alcohol Amnestic Disorder -- psychology KW - Alcohol Amnestic Disorder -- diagnosis KW - Mental Recall -- drug effects KW - Educational Measurement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79578317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=Memory+impairments+in+alcoholism%3A+effects+of+age+and+education.&rft.au=Harker%2C+J+O%3BRiege%2C+W+H&rft.aulast=Harker&rft.aufirst=J&rft.date=1989-01-01&rft.volume=1&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-12 N1 - Date created - 1995-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of neuroleptic-induced akathisia with propranolol: a controlled replication study. AN - 79568589; 2577308 AB - Twelve DSM-IIIR diagnosed schizophrenics, with neuroleptic-induced akathisia (NIA), were treated with either propranolol or matched placebo for two days, followed by a treatment crossover phase for five more days. Raters and patients were "blind" to treatment. This study shows that 120 mg of propranolol a day is more effective than placebo in reducing akathisia, and that propranolol's antiakathisic effect may require several days of treatment. JF - The Hillside journal of clinical psychiatry AU - Kramer, M S AU - Gorkin, R AU - DiJohnson, C AD - Coatesville Veterans Administration Medical Center, Pa. Y1 - 1989 PY - 1989 DA - 1989 SP - 107 EP - 119 VL - 11 IS - 2 SN - 0193-5216, 0193-5216 KW - Antipsychotic Agents KW - 0 KW - Benztropine KW - 1NHL2J4X8K KW - Propranolol KW - 9Y8NXQ24VQ KW - Index Medicus KW - Benztropine -- administration & dosage KW - Double-Blind Method KW - Akathisia, Drug-Induced KW - Dose-Response Relationship, Drug KW - Humans KW - Neurologic Examination KW - Psychomotor Agitation -- drug therapy KW - Antipsychotic Agents -- administration & dosage KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Propranolol -- administration & dosage KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79568589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Hillside+journal+of+clinical+psychiatry&rft.atitle=Treatment+of+neuroleptic-induced+akathisia+with+propranolol%3A+a+controlled+replication+study.&rft.au=Kramer%2C+M+S%3BGorkin%2C+R%3BDiJohnson%2C+C&rft.aulast=Kramer&rft.aufirst=M&rft.date=1989-01-01&rft.volume=11&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=The+Hillside+journal+of+clinical+psychiatry&rft.issn=01935216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-12 N1 - Date created - 1991-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Naltrexone in federal probationers. AN - 79548752; 2701318 JF - NIDA research monograph AU - Metzger, D S AU - Cornish, J AU - Woody, G E AU - McLellan, A T AU - Druley, P AU - O'Brien, C P AD - Center for Studies on Addiction University of Pennsylvania/Philadelphia Veterans Administration Medical Center. Y1 - 1989 PY - 1989 DA - 1989 SP - 465 EP - 466 VL - 95 SN - 1046-9516, 1046-9516 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Humans KW - Follow-Up Studies KW - Opioid-Related Disorders -- rehabilitation KW - Prisoners KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79548752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Naltrexone+in+federal+probationers.&rft.au=Metzger%2C+D+S%3BCornish%2C+J%3BWoody%2C+G+E%3BMcLellan%2C+A+T%3BDruley%2C+P%3BO%27Brien%2C+C+P&rft.aulast=Metzger&rft.aufirst=D&rft.date=1989-01-01&rft.volume=95&rft.issue=&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-20 N1 - Date created - 1990-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Properties of lipoamide dehydrogenase and thioredoxin reductase from Escherichia coli altered by site-directed mutagenesis. AN - 79513035; 2699405 JF - Annals of the New York Academy of Sciences AU - Williams, C H AU - Allison, N AU - Russell, G C AU - Prongay, A J AU - Arscott, L D AU - Datta, S AU - Sahlman, L AU - Guest, J R AD - Veterans Administration Medical Center, Ann Arbor, Michigan 48105. Y1 - 1989 PY - 1989 DA - 1989 SP - 55 EP - 65 VL - 573 SN - 0077-8923, 0077-8923 KW - Flavin-Adenine Dinucleotide KW - 146-14-5 KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - Dihydrolipoamide Dehydrogenase KW - EC 1.8.1.4 KW - Thioredoxin-Disulfide Reductase KW - EC 1.8.1.9 KW - Index Medicus KW - Kinetics KW - Spectrophotometry KW - Protein Binding KW - Flavin-Adenine Dinucleotide -- metabolism KW - Binding Sites KW - Dihydrolipoamide Dehydrogenase -- metabolism KW - Dihydrolipoamide Dehydrogenase -- genetics KW - Thioredoxin-Disulfide Reductase -- genetics KW - Thioredoxin-Disulfide Reductase -- metabolism KW - NADH, NADPH Oxidoreductases -- metabolism KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79513035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Properties+of+lipoamide+dehydrogenase+and+thioredoxin+reductase+from+Escherichia+coli+altered+by+site-directed+mutagenesis.&rft.au=Williams%2C+C+H%3BAllison%2C+N%3BRussell%2C+G+C%3BProngay%2C+A+J%3BArscott%2C+L+D%3BDatta%2C+S%3BSahlman%2C+L%3BGuest%2C+J+R&rft.aulast=Williams&rft.aufirst=C&rft.date=1989-01-01&rft.volume=573&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-31 N1 - Date created - 1990-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Collagens of normal and cirrhotic human liver. AN - 79506763; 2517247 AB - The collagens of normal and end-stage alcoholic cirrhotic human liver were investigated. Mild conditions of pepsin digestion were employed to preserved the more pepsin sensitive type IV collagen molecules while increasingly more harsh conditions were used which solubilized the type I and type III hepatic collagens. The total hepatic collagen content was elevated from 1.8-2.1 in normal liver to 7.3-8.2 percent in the end-stage alcoholic liver. The graded pepsin digestion resulted in solubilization of 76-90 percent of the total hepatic collagen. The genetically distinct types of collagen were fractionated into types I, III, IV and V preparations using judicious salt precipitation from dilute acid and neutral pH solutions. The average distribution of collagen was 42.5, 39.5, 6.9 and 10.6 percent types I, III, IV and V collagen respectively in normal liver compared to 56.6, 28.0, 5.5 and 9.6 percent respectively in the end-stage alcoholic livers. An additional 0.6 and 0.5 percent in normal and end-stage cirrhotic liver respectively were located in a fraction separating out of the salt concentration required for type VI collagen. The type IV collagen of basement membrane was separated into the constituent 95Kda alpha 1(IV) and alpha 2(IV) polypeptide chains by Agarose A 5m gel filtration with subsequent (carboxymethyl) CM-cellulose chromatography. These chains were indistinguishable from similar chains of type IV collagen isolated previously from human placenta. The type V collagen alpha chains, alpha 1(V) and alpha 2(V) were purified by a combination of Diethylaminoethyl (DEAE) and CM-cellulose chromatography. The individual chains were fragmented with cyanogen bromide to yield 9 peptides from the alpha 1(V) chain and 10 peptides from the alpha 2(V) collagen chain. These were purified and analyzed for amino acid content and molecular weight. The study suggests that all collagen types were elevated in the end-stage alcoholic liver, but type I collagen was disproportionately increased over all other collagens. These results are consistent with previous studies which demonstrated an elevated type I collagen in other fibrotic conditions such as lung fibrosis and hypertrophic scar. They do not, however, agree with the suggested disproportionate elevation of type V collagen in human alcoholic liver. The reasons for this discrepancy are discussed. JF - Connective tissue research AU - Aycock, R S AU - Seyer, J M AD - Veterans Administration Medical Center, Memphis, Tennessee 38104. Y1 - 1989 PY - 1989 DA - 1989 SP - 19 EP - 31 VL - 23 IS - 1 SN - 0300-8207, 0300-8207 KW - Amino Acids KW - 0 KW - Glycosides KW - Collagen KW - 9007-34-5 KW - Pepsin A KW - EC 3.4.23.1 KW - Cyanogen Bromide KW - OS382OHJ8P KW - Index Medicus KW - Solubility KW - Glycosides -- metabolism KW - Chromatography, Gel KW - Electrophoresis, Polyacrylamide Gel KW - Hydrogen-Ion Concentration KW - Humans KW - Amino Acids -- metabolism KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Collagen -- isolation & purification KW - Liver -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79506763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Connective+tissue+research&rft.atitle=Collagens+of+normal+and+cirrhotic+human+liver.&rft.au=Aycock%2C+R+S%3BSeyer%2C+J+M&rft.aulast=Aycock&rft.aufirst=R&rft.date=1989-01-01&rft.volume=23&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Connective+tissue+research&rft.issn=03008207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of porphyrins on skin. AN - 79490982; 2697530 AB - Porphyrins and radiation induce activation of the complement system, release of mediators from mast cells, dermal accumulation of neutrophils, and activation of factor XII-dependent pathways. Recent studies have also shown that porphyrins and radiation have profound effects on the eicosanoid metabolism of mast cells, endothelial cells, macrophages and epidermal and dermal homogenates. In vitro, prostaglandin D2 (PGD2) was generated when mast cells were exposed to protoporphyrin and radiation. Exposure of cultured human umbilical vein endothelial cells or human omental microvascular endothelial cells to uroporphyrin or protoporphyrin and radiation resulted in predominant generation of PGF2 alpha, while PGE was generated after the exposure of macrophages to Photofrin II and radiation. Activities of epidermal eicosanoid-metabolizing enzymes in protoporphyric mice were suppressed following in vivo exposure to radiation, whereas activities of the dermal enzymes were enhanced 18 h after radiation. These effects of porphyrins on skin contribute to the development of porphyrin-induced cutaneous phototoxicity, which is seen in patients with porphyrias and as a consequence of photodynamic therapy. JF - Ciba Foundation symposium AU - Lim, H W AD - Dermatology Service, New York Veterans Administration Medical Center, NY. Y1 - 1989 PY - 1989 DA - 1989 SP - 148 EP - 53; discussion 154-8 VL - 146 SN - 0300-5208, 0300-5208 KW - Porphyrins KW - 0 KW - Index Medicus KW - Animals KW - Photochemotherapy -- adverse effects KW - Humans KW - Porphyrins -- toxicity KW - Skin -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79490982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ciba+Foundation+symposium&rft.atitle=Effects+of+porphyrins+on+skin.&rft.au=Lim%2C+H+W&rft.aulast=Lim&rft.aufirst=H&rft.date=1989-01-01&rft.volume=146&rft.issue=&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Ciba+Foundation+symposium&rft.issn=03005208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-26 N1 - Date created - 1990-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Subjective dimensions of heroin urges: influence of heroin-related and affectively negative stimuli. AN - 79463704; 2618844 AB - Thirty-five male drug-free heroin addicts rated their affect, craving, and withdrawal in response to boring, anxiety-eliciting, and heroin stimuli. Results revealed that: (a) heroin cues were more effective than boring or anxiety-eliciting cues in prompting self-reports of craving or withdrawal; (b) heroin cues produced an affective state characterized by self-reported low-pleasure and high anxiety/tension; (c) craving was not correlated with any particular affective state, but rather was associated with a variety of negative affects--anxiety, depression, fatigue, anger; (d) the coherence (intercorrelations) of affective, craving, and withdrawal measures was greatest when addicts made their self-ratings immediately after exposure to drug stimuli; and (e) while addicts routinely reported craving without withdrawal sickness, they virtually never reported withdrawal sickness without reporting craving. These results suggested that the potential for negative reinforcement subserved stimulus elicited craving and that craving involved cognitive appraisal processes (attributions, expectations). JF - Addictive behaviors AU - Sherman, J E AU - Zinser, M C AU - Sideroff, S I AU - Baker, T B AD - Veterans Administration Brentwood, California. Y1 - 1989 PY - 1989 DA - 1989 SP - 611 EP - 623 VL - 14 IS - 6 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Personality Tests KW - Humans KW - Adult KW - Male KW - Motivation KW - Arousal -- drug effects KW - Cues KW - Heroin Dependence -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79463704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Subjective+dimensions+of+heroin+urges%3A+influence+of+heroin-related+and+affectively+negative+stimuli.&rft.au=Sherman%2C+J+E%3BZinser%2C+M+C%3BSideroff%2C+S+I%3BBaker%2C+T+B&rft.aulast=Sherman&rft.aufirst=J&rft.date=1989-01-01&rft.volume=14&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-08 N1 - Date created - 1990-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic idiopathic ataxic neuropathy: neuropathology of a case. AN - 79354011; 2589017 AB - A case of chronic, sporadic, slowly progressive, purely sensory, ataxic neuropathy is reported. In previously published similar cases only muscle and nerve biopsies have been available for study. In the present case the patient died of an unrelated illness 39 years after onset of the neuropathy. A full neuropathological study was performed. The disease process was limited to the dorsal root ganglia and their central and peripheral processes. Large myelinated fibers were preferentially involved. Involvement of the dorsal root ganglia has also been reported in certain toxic ganglioneuropathies and in the sensory neuropathy associated with carcinoma. The long duration and insidious development set the present case apart from those conditions. An inflammatory component was lacking. Except for a microscopic focus of adenocarcinoma of the prostate no malignancy was present. The etiology of chronic idiopathic ataxic neuropathy is unknown, but it is likely that the dorsal root ganglion is the main target for the disease process in most if not all cases. JF - Acta neuropathologica AU - Simon, L T AU - Ricaurte, G A AU - Forno, L S AD - Department of Neurology, Veterans Administration Medical Center, Palo Alto, CA 94304. Y1 - 1989 PY - 1989 DA - 1989 SP - 104 EP - 107 VL - 79 IS - 1 SN - 0001-6322, 0001-6322 KW - Index Medicus KW - Humans KW - Aged KW - Chronic Disease KW - Male KW - Ganglia, Spinal -- pathology KW - Peripheral Nerves -- pathology KW - Ataxia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79354011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+neuropathologica&rft.atitle=Chronic+idiopathic+ataxic+neuropathy%3A+neuropathology+of+a+case.&rft.au=Simon%2C+L+T%3BRicaurte%2C+G+A%3BForno%2C+L+S&rft.aulast=Simon&rft.aufirst=L&rft.date=1989-01-01&rft.volume=79&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Acta+neuropathologica&rft.issn=00016322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-10 N1 - Date created - 1990-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biases in relapse attributions made by alcoholics and their wives. AN - 79353927; 2589129 AB - Although numerous studies have investigated the relapse attributions of alcoholics, few have considered the biases inherent in such attributions. Two sources of bias were investigated in the relapse attributions of 26 alcoholic men and their wives: the passage of time and actor-observer perspective. As predicted: (a) Wives made more dispositional attributions than their husbands (an actor-observer difference); (b) the attributions of the husbands showed a dispositional shift over time, while their wives' attributions showed no temporal effects; and (c) attributional concordance within couples increased over time. Several explanations for these results were considered and implications for couples therapy with recovering alcoholics and their spouses were discussed. JF - Addictive behaviors AU - McKay, J R AU - O'Farrell, T J AU - Maisto, S A AU - Connors, G J AU - Funder, D C AD - Veterans Administration Medical Center, Brockton, Massachusetts. Y1 - 1989 PY - 1989 DA - 1989 SP - 513 EP - 522 VL - 14 IS - 5 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Internal-External Control KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Recurrence KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Alcohol Drinking -- psychology KW - Marriage KW - Attitude KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79353927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Biases+in+relapse+attributions+made+by+alcoholics+and+their+wives.&rft.au=McKay%2C+J+R%3BO%27Farrell%2C+T+J%3BMaisto%2C+S+A%3BConnors%2C+G+J%3BFunder%2C+D+C&rft.aulast=McKay&rft.aufirst=J&rft.date=1989-01-01&rft.volume=14&rft.issue=5&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-22 N1 - Date created - 1989-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Eight-drugs-in-one-day chemotherapy in postirradiated adult patients with malignant gliomas. AN - 79350694; 2586361 AB - Fifteen patients, 12 with glioblastoma multiforme and 3 with anaplastic astrocytoma, were treated with "eight-drugs-in-one-day" chemotherapy [methylprednisolone 300 mg/m2, vincristine 1.5 mg/m2 (maximum of 2 mg/cycle), CCNU 75 mg/m2, procarbazine 75 mg/m2, hydroxyurea 3,000 mg/m2, cisplatin 90 mg/m2, cytosine arabinoside 300 mg/m2, and imidazole carboxamide 150 mg/m2]. All patients had prior brain irradiation but none had previous chemotherapy. The population included 10 patients with progressive disease after irradiation and 5 who presented within 2 months of completing radiation. Patients received an average of 5 monthly cycles of chemotherapy. Three patients achieved a complete and 2 a partial response (CR + PRrate was 33%). The median survival time was 46 weeks. Myelosuppression was the dose-limiting toxicity. Leucocyte counts between 2.0-4.5 x 10(3)/mm3 were observed in 40% of patients, between 1.0- less than 2.0 x 10(3)/mm3 in 33%, and less than 1.0 x 10(3)/mm3 in 7%. Platelet counts between 50-130 x 10(3)/mm3 were observed in 27% of patients, and less than 50 x 10(3)/mm3 in 33%. Six patients suffered infections, 4 had reversible renal toxicity, 2 developed paresthesias, and one a debilitating myopathy related to treatment with dexamethasone. Ototoxicity was seen in 3 patients. Two patients developed pulmonary emboli. Nine patients had nausea and vomiting, in one case associated with Candida esophagitis. One long-term survivor developed necrosis of the corpus callosum and dementia. Four patients discontinued treatment after an average of 3.5 cycles because of toxicity. Although extremely toxic, this regimen has modest activity in previously irradiated adult patients with malignant glioma. JF - Medical and pediatric oncology AU - Rozental, J M AU - Robins, H I AU - Finlay, J AU - Healey, B AU - Levin, A B AU - Steeves, R A AU - Kohler, P C AU - Schutta, H S AU - Trump, D L AD - Neurology Service, Wm. S. Middleton Memorial Veterans Administration Hospital, Terrace, Madison, WI 53705. Y1 - 1989 PY - 1989 DA - 1989 SP - 471 EP - 476 VL - 17 IS - 6 SN - 0098-1532, 0098-1532 KW - Index Medicus KW - Drug Administration Schedule KW - Prospective Studies KW - Survival Rate KW - Combined Modality Therapy KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Glioma -- drug therapy KW - Glioma -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Glioma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79350694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+and+pediatric+oncology&rft.atitle=Eight-drugs-in-one-day+chemotherapy+in+postirradiated+adult+patients+with+malignant+gliomas.&rft.au=Rozental%2C+J+M%3BRobins%2C+H+I%3BFinlay%2C+J%3BHealey%2C+B%3BLevin%2C+A+B%3BSteeves%2C+R+A%3BKohler%2C+P+C%3BSchutta%2C+H+S%3BTrump%2C+D+L&rft.aulast=Rozental&rft.aufirst=J&rft.date=1989-01-01&rft.volume=17&rft.issue=6&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Medical+and+pediatric+oncology&rft.issn=00981532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-11 N1 - Date created - 1990-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Genotoxicity evaluation in patients on phenobarbital monotherapy by sister chromatid exchange. AN - 79340663; 2585535 AB - The potential of phenobarbital to interact with DNA has been studied using the sister chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls. All patients were otherwise healthy individuals, treated chronically with phenobarbital in monotherapy. No statistically significant differences in SCE levels were found between the patient and control groups. Smoking was associated with increased SCE frequencies. The experiment was repeated with five available patients, using a slightly modified methodology. Although different SCE scores were obtained, the results of both tests were comparable. JF - Journal of toxicology and environmental health AU - Schaumann, B A AU - Winge, V B AU - Pederson, M AD - Research Service, Veterans Administration Medical Center, Portland, OR 97207. Y1 - 1989 PY - 1989 DA - 1989 SP - 277 EP - 284 VL - 28 IS - 3 SN - 0098-4108, 0098-4108 KW - DNA KW - 9007-49-2 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Smoking -- adverse effects KW - Epilepsy -- drug therapy KW - Lymphocytes -- drug effects KW - Male KW - DNA -- drug effects KW - Cricetinae KW - Phenobarbital -- adverse effects KW - Sister Chromatid Exchange -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79340663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Genotoxicity+evaluation+in+patients+on+phenobarbital+monotherapy+by+sister+chromatid+exchange.&rft.au=Schaumann%2C+B+A%3BWinge%2C+V+B%3BPederson%2C+M&rft.aulast=Schaumann&rft.aufirst=B&rft.date=1989-01-01&rft.volume=28&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-27 N1 - Date created - 1989-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypertension and associated cardiovascular abnormalities induced by chronic barium feeding. AN - 79340612; 2585541 AB - Because high barium concentrations (2-10 ppm) in human drinking water have been reported to be associated with elevated cardiovascular mortality, hypertension and other cardiovascular effects were sought in rats chronically exposed for 1-16 mo to drinking water containing 1, 10, or 100 ppm barium. From weaning, female Long-Evans rats were kept in a "low contamination" environment and fed a diet low in trace metals. Their drinking water was deionized, fortified with 5 essential trace metals, and either 0, 1, 10, or 100 ppm barium was added. Indirect systolic pressure of unanesthetized rats was measured in triplicate at 1, 2, 4, 8, 12, and 16 mo. Average systolic pressure increased significantly after exposure to 100 ppm barium for 1 mo or longer and after exposure to 10 ppm barium for 8 mo or longer. After 4 or 16 mo, barium exposure failed to alter organ weights or tissue concentrations of calcium, magnesium, sodium, or potassium; however, both 10 and 100 ppm barium resulted in significant increases in tissue barium. Rats exposed to 100 ppm Ba for 16 mo exhibited depressed rates of cardiac contraction and depressed electrical excitability in the heart. Hearts from these maximally exposed rats also had significantly lower ATP content and phosphorylation potential, as measured by 31P NMR spectroscopy. Although the barium-induced increase in the blood pressure of rats was modest, comparable mild hypertension in humans would have major health implications. JF - Journal of toxicology and environmental health AU - Perry, H M AU - Kopp, S J AU - Perry, E F AU - Erlanger, M W AD - Medical Service, Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1989 PY - 1989 DA - 1989 SP - 373 EP - 388 VL - 28 IS - 3 SN - 0098-4108, 0098-4108 KW - Barium KW - 24GP945V5T KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Water Supply KW - Heart -- drug effects KW - Myocardial Contraction -- drug effects KW - Blood Pressure -- drug effects KW - Female KW - Pentobarbital -- pharmacology KW - Organ Size -- drug effects KW - Hypertension -- chemically induced KW - Barium -- adverse effects KW - Cardiovascular System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79340612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Do+transcriptional+enhancers+also+augment+DNA+replication%3F&rft.au=O%27Connor%2C+D+T%3BSubramani%2C+S&rft.aulast=O%27Connor&rft.aufirst=D&rft.date=1988-12-09&rft.volume=16&rft.issue=23&rft.spage=11207&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-27 N1 - Date created - 1989-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clozapine: neuroleptic-induced EPS and tardive dyskinesia. AN - 79301859; 2682732 AB - Clozapine has had a uniquely favorable motor system side effect profile since its initial evaluations. This has been convincingly corroborated by many double blind, single blind, and open studies treating acute and chronic psychosis. The acute extrapyramidal syndromes of dystonia, akathisia and parkinsonism infrequently occur, whereas these syndromes develop in up to 75% of patients receiving traditional neuroleptics. Tardive dyskinesia can be suppressed with higher doses of clozapine given over extended periods. However, an antipsychotic effect can be achieved in many patients at doses below the dyskinesia suppressing level. There is no established causative relationship between clozapine and tardive dyskinesia, but there is a theoretical basis that this may occur. Preliminary data suggest clozapine has mild antiparkinsonian effects as well as efficacy in controlling dopamine agonist-induced psychosis without aggravating parkinsonism. A much wider use of clozapine will further characterize the magnitude of differences compared to other neuroleptics, and identify additional indications for this special compound. JF - Psychopharmacology AU - Casey, D E AD - Psychopharmacology Research, Veterans Administration Medical Center, Portland, Oregon 97207. Y1 - 1989 PY - 1989 DA - 1989 SP - S47 EP - S53 VL - 99 Suppl SN - 0033-3158, 0033-3158 KW - Dibenzazepines KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Humans KW - Basal Ganglia Diseases -- physiopathology KW - Dyskinesia, Drug-Induced -- physiopathology KW - Dibenzazepines -- adverse effects KW - Clozapine -- adverse effects KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79301859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Clozapine%3A+neuroleptic-induced+EPS+and+tardive+dyskinesia.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1989-01-01&rft.volume=99+Suppl&rft.issue=&rft.spage=S47&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Membrane receptors for peptides in experimental and human pancreatic cancers. AN - 79301433; 2573055 AB - Membrane receptors for [D-Trp6]-luteinizing hormone-releasing hormone [( D-Trp6]-LH-RH), somatostatin (SS-14), and epidermal growth factor (EGF) were investigated in experimental N-nitrosobis-(2-oxopropyl)-amine (BOP)-induced pancreatic cancers of hamsters and in specimens of normal human pancreas and human pancreatic cancer obtained from autopsies. Membrane receptors for [D-Trp6]-LH-RH were absent in the pancreas of normal hamsters, but appeared after the carcinoma was induced with BOP. Binding capacity of SS-14 receptors was lower in membranes of BOP-induced pancreatic cancers than in the normal pancreas. In the BOP-induced pancreatic cancers, the receptors were also characterized following in vivo treatment of hamsters with microcapsules of the agonist [D-Trp6]-LH-RH, somatostatin analog RC-160, and the combination of both peptides, which resulted in significant tumor inhibition. Therapy with [D-Trp6]-LH-RH and RC-160, alone or in combination, decreased the binding capacity of receptors for [D-Trp6]-LH-RH, but increased Bmax for SS-14. There were no significant changes in characteristics of the EGF receptor following these therapies. Membranes from human pancreatic cancers showed binding sites for [D-Trp6]-LH-RH, but no binding was detected in normal human pancreas. The presence of receptors for LH-RH in pancreatic tumors of hamster and humans raises the intriguing possibility that LH-RH could be involved in complex interactions that contribute to the appearance of pancreatic cancer. The binding capacity of receptors for SS-14 in human pancreatic cancer membranes was lower, while Bmax for EGF was higher, as compared to normal pancreas.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pancreas AU - Fekete, M AU - Zalatnai, A AU - Comaru-Schally, A M AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana 70146. Y1 - 1989 PY - 1989 DA - 1989 SP - 521 EP - 528 VL - 4 IS - 5 SN - 0885-3177, 0885-3177 KW - Antineoplastic Agents KW - 0 KW - Carcinogens KW - Nitrosamines KW - Receptors, LHRH KW - Receptors, Somatotropin KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Luteinizing Hormone KW - 9002-67-9 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Autopsy KW - Carcinogens -- pharmacology KW - Humans KW - Luteinizing Hormone -- pharmacology KW - Antineoplastic Agents -- metabolism KW - Nitrosamines -- adverse effects KW - Somatostatin -- pharmacology KW - Gonadotropin-Releasing Hormone -- metabolism KW - Mesocricetus KW - Antineoplastic Agents -- pharmacology KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Female KW - Cricetinae KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- analysis KW - Receptors, Somatotropin -- analysis KW - Adenocarcinoma -- chemically induced KW - Receptors, LHRH -- analysis KW - Pancreatic Neoplasms -- chemically induced KW - Adenocarcinoma -- analysis KW - Adenocarcinoma -- ultrastructure KW - Receptor, Epidermal Growth Factor -- analysis KW - Pancreatic Neoplasms -- ultrastructure KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79301433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pancreas&rft.atitle=Membrane+receptors+for+peptides+in+experimental+and+human+pancreatic+cancers.&rft.au=Fekete%2C+M%3BZalatnai%2C+A%3BComaru-Schally%2C+A+M%3BSchally%2C+A+V&rft.aulast=Fekete&rft.aufirst=M&rft.date=1989-01-01&rft.volume=4&rft.issue=5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Pancreas&rft.issn=08853177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-29 N1 - Date created - 1989-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcitonin production: an examination of the regulatory effects of extracellular calcium and 1,25-dihydroxyvitamin D3. AN - 79292555; 2807150 AB - Acute elevations of the serum calcium concentration stimulate release of preformed calcitonin. Whether chronic alterations of the serum calcium of 1,25 dihydroxyvitamin D3 concentrations cause an effect on synthesis or secretion of this major calcium-regulating hormone has not been determined with certainty. Recent studies, including those presented in this manuscript, indicate that 1,25 dihydroxyvitamin D3 and, perhaps, increases of the serum calcium concentration inhibit transcription of the calcitonin gene resulting in decreased production of calcitonin. Inhibition of calcitonin production in the hypercalcemic or vitamin D toxic patient may play a role in the pathophysiology of these conditions. JF - Hormone and metabolic research. Supplement series AU - Cote, G J AU - Huang, E S AU - Gagel, R F AD - Laboratory of Molecular and Cellular Endocrinology, Veterans Administration Medical Center, Houston, Texas. Y1 - 1989 PY - 1989 DA - 1989 SP - 15 EP - 18 VL - 21 SN - 0170-5903, 0170-5903 KW - RNA, Messenger KW - 0 KW - Calcitonin KW - 9007-12-9 KW - Calcitriol KW - FXC9231JVH KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Gene Expression -- drug effects KW - Tumor Cells, Cultured -- metabolism KW - RNA, Messenger -- metabolism KW - Carcinoma -- pathology KW - Thyroid Neoplasms -- metabolism KW - Humans KW - Tumor Cells, Cultured -- pathology KW - Thyroid Neoplasms -- pathology KW - RNA, Messenger -- genetics KW - Carcinoma -- metabolism KW - Cell Line KW - Calcitonin -- metabolism KW - Calcitriol -- physiology KW - Calcium -- physiology KW - Calcium -- pharmacology KW - Calcitonin -- genetics KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79292555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hormone+and+metabolic+research.+Supplement+series&rft.atitle=Calcitonin+production%3A+an+examination+of+the+regulatory+effects+of+extracellular+calcium+and+1%2C25-dihydroxyvitamin+D3.&rft.au=Cote%2C+G+J%3BHuang%2C+E+S%3BGagel%2C+R+F&rft.aulast=Cote&rft.aufirst=G&rft.date=1989-01-01&rft.volume=21&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Hormone+and+metabolic+research.+Supplement+series&rft.issn=01705903&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-19 N1 - Date created - 1989-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of intravenous vancomycin on renal function. AN - 79225454; 2791709 AB - In the past, vancomycin has been reported to cause renal failure during intravenous administration; however, more recently, such renal toxicity is alleged not to occur because of increased purity of the vancomycin preparations. In this study, 23 patients were prospectively examined during intravenous vancomycin administration for changes in renal function. Vancomycin was administered for an average of 15 days. The blood urea nitrogen (BUN) changes averaged +1.7 mg/dl and the creatinine changes averaged +0.06 mg/dl. Since the accuracy of the serum creatinine determination was +/- 0.3 mg/dl, clinically significant deterioration of renal function occurred in 4 patients or 17%. Even among these 4 patients with documented worsening of renal function, we suspect that deterioration was related to the infection being treated. With close monitoring of dosing, the propensity of vancomycin to cause nephrotoxicity may be less than once thought. JF - Chemotherapy AU - Eng, R H AU - Wynn, L AU - Smith, S M AU - Tecson-Tumang, F AD - Infectious Disease Section, Veterans Administration Medical Center, East Orange, N.J. Y1 - 1989 PY - 1989 DA - 1989 SP - 320 EP - 325 VL - 35 IS - 5 SN - 0009-3157, 0009-3157 KW - Vancomycin KW - 6Q205EH1VU KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Prospective Studies KW - Injections, Intravenous KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Male KW - Vancomycin -- adverse effects KW - Vancomycin -- administration & dosage KW - Kidney -- drug effects KW - Vancomycin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79225454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Effect+of+intravenous+vancomycin+on+renal+function.&rft.au=Eng%2C+R+H%3BWynn%2C+L%3BSmith%2C+S+M%3BTecson-Tumang%2C+F&rft.aulast=Eng&rft.aufirst=R&rft.date=1989-01-01&rft.volume=35&rft.issue=5&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Chemotherapy&rft.issn=00093157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-21 N1 - Date created - 1989-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Genotoxicity of [1H]benz[de]isoquinoline-1,3[2H]dione,5 amino-2-,[2-dimethylamino) ethyl] (BIDA) in human lymphocytes. AN - 79216943; 2790535 AB - We have investigated the genotoxicity of BIDA in cultured human lymphocytes. Lymphocytes were cultured and stimulated with phytohemagglutinin (PHA) for 72 h. Doses of 0.1, 0.25, 0.5, 0.75, and 1 microgram/ml of BIDA were added to the culture at 1 h (G2 phase), and 6 h (S/G2 phase) before harvesting. Cells were harvested at the end of the 72-h culture period with 1-h colcemid treatment to accumulate mitosis, and further prepared by standard cytogenetic technique. BIDA induced chromatic type breakages and chromatid exchanges at both 1 h and 6 h. The mean number of breakages per cell was 0, 0.1, 1.0, and 1.7 after treatment with 0.1, 0.25, and 0.75 micrograms/ml, respectively. Ai 1 microgram/ml, BIDA severely inhibited cell progression and very few mitoses were observed. At 6 h the mean number of breakages per cell was 0.3 at 0.25 microgram/ml and 1.2 at 0.5 microgram/ml. Very few cells entered mitosis at 0.75 and 1 microgram/ml. To study the effect of BIDA on cells in G0 and G1, BIDA (0.75 microgram/ml) was added for 1 h to the cultures at the beginning of culture (G0), or 24 h after (G1) culture initiation. Afterward, cells were washed and reincubated in the conditioned medium for 71 or 47 h. No chromosomal aberrations were seen in these experiments. The number of chromatid breaks was minimal (0.1 to 0.4/cell). Our study suggests that BIDA induces chromatid type aberrations during G2 and S phases. The absence of chromosome type aberrations in cells treated during G0 and G1 suggests that either BIDA has no effect on these cells or that damaged cells fail to progress through S and G2 to reach mitosis. JF - Cancer investigation AU - Savaraj, N AU - Liang, J AU - Lu, K AU - Feun, L G AU - Hsu, T C AD - Veterans Administration Medical Center, Miami, Florida 33125. Y1 - 1989 PY - 1989 DA - 1989 SP - 117 EP - 121 VL - 7 IS - 2 SN - 0735-7907, 0735-7907 KW - Antineoplastic Agents KW - 0 KW - Imides KW - Isoquinolines KW - Mutagens KW - Naphthalimides KW - Phytohemagglutinins KW - amonafide KW - 1Q8D39N37L KW - Index Medicus KW - Lymphocyte Activation KW - Cells, Cultured KW - Humans KW - Adult KW - Interphase KW - Phytohemagglutinins -- pharmacology KW - Male KW - Isoquinolines -- pharmacology KW - Sister Chromatid Exchange KW - Chromosome Aberrations KW - Lymphocytes -- ultrastructure KW - Lymphocytes -- drug effects KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79216943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Genotoxicity+of+%5B1H%5Dbenz%5Bde%5Disoquinoline-1%2C3%5B2H%5Ddione%2C5+amino-2-%2C%5B2-dimethylamino%29+ethyl%5D+%28BIDA%29+in+human+lymphocytes.&rft.au=Savaraj%2C+N%3BLiang%2C+J%3BLu%2C+K%3BFeun%2C+L+G%3BHsu%2C+T+C&rft.aulast=Savaraj&rft.aufirst=N&rft.date=1989-01-01&rft.volume=7&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-07 N1 - Date created - 1989-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - ras oncogene p21 expression in hepatocellular carcinoma. AN - 79199587; 2550600 AB - Aberrant proto-oncogene expression has been implicated in hepatic cell proliferation, transformation and carcinogenesis using a rat model. To investigate the role of ras p21 product expression in human hepatocellular carcinoma (HCC), we have localized ras p21 in formalin fixed, paraffin-embedded normal and abnormal livers utilizing the avidin-biotin peroxidase method and a monoclonal antibody to ras-gene product p21. A semi-quantitative estimate of p21 expression was performed by serial dilutions of primary antibody. While low dilutions of anti-p21 stained normal hepatocytes, higher dilutions failed to react with normal hepatocytes and these dilutions were used for assessment of p21 enhancement. Increased p21 expression of ras oncogene in HCC occurs in fibrolamellar carcinomas and other better differentiated HCC. Tumor dedifferentiation is associated with an attenuation of p21 expression. Liver adjacent to HCC exhibits p21 enhancement, in contrast to liver surrounding metastatic carcinoma, suggesting increased p21 expression in HCC induction. JF - Journal of experimental pathology AU - Jagirdar, J AU - Nonomura, A AU - Patil, J AU - Thor, A AU - Paronetto, F AD - Immunopathology Laboratory, Veterans Administration Medical Center, Bronx, NY. Y1 - 1989 PY - 1989 DA - 1989 SP - 37 EP - 46 VL - 4 IS - 1 SN - 0730-8485, 0730-8485 KW - Proto-Oncogene Proteins KW - 0 KW - HRAS protein, human KW - EC 3.6.5.2 KW - Proto-Oncogene Proteins p21(ras) KW - Index Medicus KW - Liver -- cytology KW - Humans KW - Fetus -- cytology KW - Liver -- metabolism KW - Gene Expression Regulation KW - Immunohistochemistry KW - Fetus -- metabolism KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Proto-Oncogene Proteins -- metabolism KW - Carcinoma, Hepatocellular -- pathology KW - Proto-Oncogene Proteins -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+pathology&rft.atitle=ras+oncogene+p21+expression+in+hepatocellular+carcinoma.&rft.au=Jagirdar%2C+J%3BNonomura%2C+A%3BPatil%2C+J%3BThor%2C+A%3BParonetto%2C+F&rft.aulast=Jagirdar&rft.aufirst=J&rft.date=1989-01-01&rft.volume=4&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+pathology&rft.issn=07308485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Were the hatters of New Jersey "mad"? AN - 79199235; 2672802 AB - Conventional wisdom holds that the "Mad Hatter" of Alice's Adventures in Wonderland earned his name because he exhibited psychotic behavior from mercury poisoning. The first description of mercurialism in hatters was published by J. Addision Freeman, M.D., in Transactions of the Medical Society of New Jersey in 1860, just 5 years before Lewis Carrol's famous tale. But it is unlikely that Alice's creator was aware of this obscure provincial report. Numerous subsequent studies of hatters in New Jersey showed that the hatters' shakes were rampant among the immigrant workers. The pathologic shyness of mercurialism, however, was not noted in New Jersey hatters until 1912. The idea that hatters were "mad" stemmed from popular perceptions more than from medical knowledge. Nor did medical studies lead to elimination of mercury in felt hat manufacturing. The hatters' occupational disease was curbed only in 1941 when mercury was required for the manufacture of detonators in World War II. The hatters of New Jersey were not only not mad, but neither were they, the physicians, nor the public of the period sufficiently angry to control the conditions under which the hatters worked. JF - American journal of industrial medicine AU - Wedeen, R P AD - Veterans Administration Medical Center, East Orange, NJ 07019. Y1 - 1989 PY - 1989 DA - 1989 SP - 225 EP - 233 VL - 16 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - History of medicine KW - History, 20th Century KW - Humans KW - History, 19th Century KW - New Jersey KW - Clothing -- history KW - Mercury Poisoning -- history KW - Occupational Diseases -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79199235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Were+the+hatters+of+New+Jersey+%22mad%22%3F&rft.au=Wedeen%2C+R+P&rft.aulast=Wedeen&rft.aufirst=R&rft.date=1989-01-01&rft.volume=16&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-27 N1 - Date created - 1989-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thrombosis associated with procainamide-induced lupus anticoagulant. AN - 79195561; 2505475 AB - A predisposition to thrombosis in patients with procainamide-induced lupus anticoagulants is previously unrecognized. We describe two patients treated with procainamide who experienced acute thromboembolic events temporally associated with development of the lupus anticoagulant. One patient had a deep venous thrombosis and pulmonary embolism, while the other patient had a cerebrovascular accident. In both patients, coagulation parameters corrected with interruption of procainamide therapy. We suggest that thrombosis may complicate treatment with procainamide in patients who develop the lupus anticoagulant. JF - Acta haematologica AU - List, A F AU - Doll, D C AD - Department of Medicine, Veterans Administration Medical Center, Phoenix, Ariz. Y1 - 1989 PY - 1989 DA - 1989 SP - 50 EP - 52 VL - 82 IS - 1 SN - 0001-5792, 0001-5792 KW - Blood Coagulation Factors KW - 0 KW - Lupus Coagulation Inhibitor KW - Procainamide KW - L39WTC366D KW - Index Medicus KW - Thromboembolism -- blood KW - Thromboembolism -- etiology KW - Pulmonary Embolism -- etiology KW - Thrombophlebitis -- etiology KW - Pulmonary Embolism -- blood KW - Humans KW - Autoimmune Diseases -- etiology KW - Aged KW - Middle Aged KW - Autoimmune Diseases -- blood KW - Thrombophlebitis -- blood KW - Male KW - Procainamide -- adverse effects KW - Thrombosis -- blood KW - Thrombosis -- etiology KW - Blood Coagulation Factors -- physiology KW - Blood Coagulation Factors -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79195561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+haematologica&rft.atitle=Thrombosis+associated+with+procainamide-induced+lupus+anticoagulant.&rft.au=List%2C+A+F%3BDoll%2C+D+C&rft.aulast=List&rft.aufirst=A&rft.date=1989-01-01&rft.volume=82&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Acta+haematologica&rft.issn=00015792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-03 N1 - Date created - 1989-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A double-blind comparison of flurbiprofen with diflunisal in the treatment of acute ankle sprains and strains. AN - 79193613; 2776469 AB - Fifty patients with acute ankle sprains/strains were treated with either 100 mg flurbiprofen or 500 mg diflunisal twice daily in a double-blind fashion for 18 days or until symptoms of the injury resolved. Tolerability of the drugs was evaluated by recording the occurrence of adverse drug reactions and monitoring laboratory parameters. Efficacy measurements were performed at enrollment and at Visit 2-Day 7, Visit 3-Day 14 and Visit 4-Day 21 to determine relief of symptoms and return to normal activities. Patients in both treatment groups exhibited marked improvement by Visit 2-Day 7 with almost complete recovery by Visit 3-Day 14. Flurbiprofen patients had a significantly shorter duration of therapy. Results from three of the six physician assessments were marginally to significantly superior for patients in the flurbiprofen group. The only reported adverse event was mild gastro-intestinal intolerance in a patient receiving diflunisal. Flurbiprofen and diflunisal appear to be effective and well-tolerated medications for the treatment of acute ankle sprains and strains. JF - Current medical research and opinion AU - Finch, W F AU - Zanaga, P AU - Mickelson, M M AU - Grochowski, K J AD - Veterans Administration Medical Center, Phoenix, AZ. Y1 - 1989 PY - 1989 DA - 1989 SP - 409 EP - 416 VL - 11 IS - 7 SN - 0300-7995, 0300-7995 KW - Propionates KW - 0 KW - Salicylates KW - Flurbiprofen KW - 5GRO578KLP KW - Diflunisal KW - 7C546U4DEN KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Ankle Injuries KW - Sprains and Strains -- drug therapy KW - Flurbiprofen -- therapeutic use KW - Propionates -- therapeutic use KW - Salicylates -- therapeutic use KW - Diflunisal -- therapeutic use KW - Diflunisal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79193613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=A+double-blind+comparison+of+flurbiprofen+with+diflunisal+in+the+treatment+of+acute+ankle+sprains+and+strains.&rft.au=Finch%2C+W+F%3BZanaga%2C+P%3BMickelson%2C+M+M%3BGrochowski%2C+K+J&rft.aulast=Finch&rft.aufirst=W&rft.date=1989-01-01&rft.volume=11&rft.issue=7&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=03007995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-26 N1 - Date created - 1989-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aluminum-induced neurotoxicity: alterations in membrane function at the blood-brain barrier. AN - 79182298; 2671833 AB - Aluminum is established as a neurotoxin, although the basis for its toxicity is unknown. It recently has been shown to alter the function of the blood-brain barrier (BBB), which regulates exchanges between the central nervous system (CNS) and peripheral circulation. The BBB owes its unique properties to the integrity of the cell membranes that comprise it. Aluminum affects some of the membrane-like functions of the BBB. It increases the rate of transmembrane diffusion and selectively changes saturable transport systems without disrupting the integrity of the membranes or altering CNS hemodynamics. Such alterations in the access to the brain of nutrients, hormones, toxins, and drugs could be the basis of CNS dysfunction. Aluminum is capable of altering membrane function at the BBB; many of its effects on the CNS as well as peripheral tissues can be explained by its actions as a membrane toxin. JF - Neuroscience and biobehavioral reviews AU - Banks, W A AU - Kastin, A J AD - Veterans Administration Medical Center, New Orleans, LA. Y1 - 1989 PY - 1989 DA - 1989 SP - 47 EP - 53 VL - 13 IS - 1 SN - 0149-7634, 0149-7634 KW - Neurotoxins KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Animals KW - Cell Membrane -- drug effects KW - Humans KW - Brain -- pathology KW - Brain -- drug effects KW - Blood-Brain Barrier -- drug effects KW - Aluminum -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79182298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+and+biobehavioral+reviews&rft.atitle=Aluminum-induced+neurotoxicity%3A+alterations+in+membrane+function+at+the+blood-brain+barrier.&rft.au=Banks%2C+W+A%3BKastin%2C+A+J&rft.aulast=Banks&rft.aufirst=W&rft.date=1989-01-01&rft.volume=13&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Neuroscience+and+biobehavioral+reviews&rft.issn=01497634&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-27 N1 - Date created - 1989-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - gamma Vinyl GABA: current role in the management of drug-resistant epilepsy. AN - 79170319; 2767018 AB - The goal of management in epilepsy is to make patients completely seizure-free without side effects. Currently, this goal can be achieved fully in only about one-half of the 50,000,000 people in the world with epilepsy. Epilepsy is not a benign condition. Uncontrolled epilepsy produces significant morbidity and mortality. Even infrequent seizures put a patient at risk of sudden death and compromise employability and other social functions. The potential risk of a new antiepileptic drug has to be weighted against the potential risk of continuing seizures and the potential for the new drug to control those seizures. Vigabatrin (gamma vinyl GABA, GVG) is one of the promising new antiepileptic drugs now under development. In four large clinical trials half of the patients in each trial had a greater than or equal to 50% reduction in seizure frequency when GVG was added to existing antiepileptic drug. This represents a significant response rate in add-on trials, which are a severe test of a new antiepileptic drug. Although microvacuoles have been seen in the white matter of the brains of rats and dogs treated with GVG, such pathological changes have not yet been observed in humans. Evoked potential studies have failed to reveal any evidence of microvacuolization in humans. Because of the potential efficacy of GVG in controlling previously therapeutic-resistant seizures and of the absence of evidence of significant toxicity in humans, carefully monitored clinical trials of GVG in therapy-resistant patients with epilepsy should continue. JF - Epilepsia AU - Treiman, D M AD - Neurology Service, Veterans Administration West Los Angeles Medical Center 90024. Y1 - 1989 PY - 1989 DA - 1989 SP - S31 EP - S35 VL - 30 Suppl 3 SN - 0013-9580, 0013-9580 KW - Aminocaproates KW - 0 KW - Anticonvulsants KW - Vigabatrin KW - GR120KRT6K KW - Index Medicus KW - Humans KW - Drug Resistance KW - Anticonvulsants -- adverse effects KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Aminocaproates -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79170319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=gamma+Vinyl+GABA%3A+current+role+in+the+management+of+drug-resistant+epilepsy.&rft.au=Treiman%2C+D+M&rft.aulast=Treiman&rft.aufirst=D&rft.date=1989-01-01&rft.volume=30+Suppl+3&rft.issue=&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Attitudes of mental health professionals toward alcoholism recognition and treatment. AN - 79157501; 2763987 AB - The attitudes of 100 urban mental health professionals toward alcoholism diagnosis and treatment were assessed using a 23-item questionnaire. A significant number of those sampled, physicians more than other professional groups, looked upon alcoholism as a disease in its own right. Physicians, attendings more than residents, subscribed to a more medical history-taking model. While the majority of those surveyed would advise complete sobriety, a large number would not. Likewise, despite a large percentage of our sample who indicated familiarity with alcohol-related concepts, a significant number did not. Referral to Alcoholics Anonymous was highly endorsed by those advocating sobriety. The meaning of these findings is discussed in relation to the marked improvement noted in professionals' attitudes toward alcoholic patients. Based on these findings, methods of further improving the clinician's awareness of alcoholism are considered. JF - The American journal of drug and alcohol abuse AU - Schwartz, L S AU - Taylor, J R AD - Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611. Y1 - 1989 PY - 1989 DA - 1989 SP - 321 EP - 337 VL - 15 IS - 3 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Psychiatric Department, Hospital KW - Middle Aged KW - Male KW - Female KW - Psychological Tests KW - Alcoholism -- rehabilitation KW - Attitude of Health Personnel KW - Alcoholism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Attitudes+of+mental+health+professionals+toward+alcoholism+recognition+and+treatment.&rft.au=Schwartz%2C+L+S%3BTaylor%2C+J+R&rft.aulast=Schwartz&rft.aufirst=L&rft.date=1989-01-01&rft.volume=15&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-19 N1 - Date created - 1989-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gastric cancer: a neoplastic enigma. AN - 79157291; 2669794 AB - Effective therapy for gastric cancer remains elusive, and thus surgeons, oncologists, and radiotherapists are continually confounded. Multiple attempts to improve survival in gastric cancer patients have failed, including extended lymphadenectomy (by American surgeons), single- or multiple-agent chemotherapy, and combined-modality therapy (multiple-agent chemotherapy combined with radiation therapy). Such studies have been plagued by the high volume of inadequate antitumor responses or by lethal toxicity. At present, chemotherapy remains the best hope for effective adjuvant therapy, but new routes of drug delivery that will decrease systemic toxicity must be developed. Since gastric cancer recurs locoregionally and infrequently metastasizes to distant sites until very late in its course, theory suggests intraperitoneal (IP) chemotherapy applied to locoregional sites should decrease recurrence without significant systemic toxicity. Such treatments have been effective in other malignancies that commonly occur IP, such as ovarian cancer. Intracavitary chemotherapy protocols for gastric cancer are under development and will soon produce data on treatment efficacy. Such studies offer a theoretic basis for improved survival from gastric cancer; however, only well-controlled treatment trials will confirm if theory can be translated into clinical reality. JF - Journal of surgical oncology. Supplement AU - Kern, K A AD - Department of Surgery, Hartford Veterans Administration Medical Center, Newington, Connecticut. Y1 - 1989 PY - 1989 DA - 1989 SP - 34 EP - 39 VL - 1 SN - 1046-7416, 1046-7416 KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adenocarcinoma -- therapy KW - Lymph Node Excision KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Infusions, Parenteral KW - Stomach Neoplasms -- therapy KW - Stomach Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology.+Supplement&rft.atitle=Gastric+cancer%3A+a+neoplastic+enigma.&rft.au=Kern%2C+K+A&rft.aulast=Kern&rft.aufirst=K&rft.date=1989-01-01&rft.volume=1&rft.issue=&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology.+Supplement&rft.issn=10467416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-05 N1 - Date created - 1989-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thoracic vertebral photopenia may predict fatty changes of the corresponding bone marrow following irradiation. AN - 79155254; 2762587 AB - We present a patient with unresectable bronchogenic carcinoma who underwent irradiation, then had four consecutive bone imaging studies in a 26-month period. Apparent photopenia of the upper thoracic vertebrae developed within six months after irradiation and became more apparent in the images thereafter. At autopsy a section of the corresponding bone marrow showed extensive fatty changes with very few residual blood vessels. Radiation damage of the vascular networks may significantly reduce the blood supply, when integrity of the blood supply is essential for delivery of a normal bone image by the bone-imaging agent. Interruption of blood supply may cause photopenia, and this interruption plus irradiation to marrow elements may also affect the hematopoietic activity of the corresponding bone marrow. The occurrence of radiation-induced photopenia on a bone-imaging study may indicate fatty changes of the corresponding marrow. JF - Radiation medicine AU - Shih, W J AU - Li, C Y AU - Coffey, C W AU - Maruyama, Y AD - Nuclear Medicine Division, Veterans Administration Medical Center, Lexington, Kentucky. PY - 1989 SP - 32 EP - 35 VL - 7 IS - 1 SN - 0288-2043, 0288-2043 KW - Index Medicus KW - Lung Neoplasms -- radiotherapy KW - Humans KW - Middle Aged KW - Carcinoma, Bronchogenic -- radiotherapy KW - Male KW - Radionuclide Imaging KW - Thoracic Vertebrae -- radiation effects KW - Thoracic Vertebrae -- diagnostic imaging KW - Bone Marrow -- radiation effects KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79155254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+medicine&rft.atitle=Thoracic+vertebral+photopenia+may+predict+fatty+changes+of+the+corresponding+bone+marrow+following+irradiation.&rft.au=Shih%2C+W+J%3BLi%2C+C+Y%3BCoffey%2C+C+W%3BMaruyama%2C+Y&rft.aulast=Shih&rft.aufirst=W&rft.date=1989-01-01&rft.volume=7&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Radiation+medicine&rft.issn=02882043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of hypocalcemia on renal phosphorus handling in the rat: interaction with dietary phosphorus and PTH. AN - 79140264; 2548070 AB - The effect of Na-EGTA induced hypocalcemia was investigated in chronically parathyroidectomized (PTX) rats. In dietary inorganic phosphorus (Pi) replete animals, reduction in the plasma calcium to 1.37 +/- 0.03 mM at constant filtered loads of Pi had no effect on tubular reabsorption of phosphorus (85 +/- 3 vs. 83 +/- 2 micrograms/ml, NS). In dietary Pi-deprived rats, where an elevation of plasma calcium is a known accompaniment, similar reduction in plasma calcium concentration also failed to alter (89 +/- 2 vs. 90 +/- 2 micrograms/ml, NS) phosphorus reabsorption. Resistance to parathyroid hormone (PTH) in dietary Pi deprivation was confirmed. Super imposition of PTH on EGTA induced hypocalcemia during dietary Pi deprivation, however, resulted in a significant reduction in tubular Pi reabsorption (81 +/- 2 vs. 67 +/- 3 micrograms/ml, p less than 0.05) with full restoration of its phosphaturic action. These changes were unaccompanied by differences in urinary adenosine 3',5'-cyclic phosphate (cAMP). In conclusion, hypocalcemia per se does not alter the renal handling of phosphorus at constant plasma Pi concentrations. The elevation in the plasma calcium associated with dietary Pi deprivation does not contribute importantly to the hypophosphaturia of dietary Pi deprivation. Hypocalcemia, however, abolishes the resistance to PTH observed in Pi deprivation. JF - Mineral and electrolyte metabolism AU - Guntupalli, J AU - Bourke, E AD - Department of Medicine, Veterans Administration Medical Center, Atlanta, Ga. Y1 - 1989 PY - 1989 DA - 1989 SP - 201 EP - 208 VL - 15 IS - 4 SN - 0378-0392, 0378-0392 KW - Parathyroid Hormone KW - 0 KW - Phosphorus KW - 27YLU75U4W KW - Egtazic Acid KW - 526U7A2651 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Extracellular Space -- physiology KW - Parathyroid Glands -- physiology KW - Diet KW - Cyclic AMP -- urine KW - Male KW - Parathyroid Hormone -- physiology KW - Phosphorus -- urine KW - Phosphorus -- metabolism KW - Phosphorus -- deficiency KW - Hypocalcemia -- physiopathology KW - Kidney -- physiopathology KW - Hypocalcemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79140264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineral+and+electrolyte+metabolism&rft.atitle=Effect+of+hypocalcemia+on+renal+phosphorus+handling+in+the+rat%3A+interaction+with+dietary+phosphorus+and+PTH.&rft.au=Guntupalli%2C+J%3BBourke%2C+E&rft.aulast=Guntupalli&rft.aufirst=J&rft.date=1989-01-01&rft.volume=15&rft.issue=4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Mineral+and+electrolyte+metabolism&rft.issn=03780392&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-08 N1 - Date created - 1989-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Captopril-associated acute interstitial nephritis. AN - 79133614; 2527007 AB - A 57-year-old male with mild impairment of renal function secondary to diabetic glomerulosclerosis developed acute renal failure (creatinine 32.4 mg/dl) associated with a generalized desquamative skin rash and peripheral eosinophilia shortly after initiation of antihypertensive therapy with captopril. An acute interstitial nephritis was demonstrated on renal biopsy, and improvement was temporally related to initiation of therapy with prednisone. A review of the literature revealed 5 similar cases in whom acute deterioration of renal function occurred following initiation of captopril and in whom there were features of a hypersensitivity reaction, including skin rash, fever, eosinophilia, azotemia, eosinophiluria, and a Coombs-positive hemolytic anemia. Renal biopsy, where available, revealed an acute interstitial nephritis. Observations from these cases suggest that, of the angiotensin-converting enzyme inhibitors, this syndrome appears to be specific for captopril, begins within the 1st month of therapy, is not dose-dependent, and generally resolves on cessation of therapy. Steroids may hasten recovery, but sufficient data are not available to confirm their efficacy. JF - American journal of nephrology AU - Smith, W R AU - Neill, J AU - Cushman, W C AU - Butkus, D E AD - Department of Medicine, Jackson Veterans Administration Medical Center, Miss. Y1 - 1989 PY - 1989 DA - 1989 SP - 230 EP - 235 VL - 9 IS - 3 SN - 0250-8095, 0250-8095 KW - Captopril KW - 9G64RSX1XD KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Drug Eruptions -- etiology KW - Acute Kidney Injury -- drug therapy KW - Acute Kidney Injury -- pathology KW - Prednisone -- therapeutic use KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Middle Aged KW - Male KW - Drug Eruptions -- drug therapy KW - Nephritis, Interstitial -- drug therapy KW - Captopril -- adverse effects KW - Drug Hypersensitivity -- etiology KW - Nephritis, Interstitial -- chemically induced KW - Nephritis, Interstitial -- pathology KW - Drug Hypersensitivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79133614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+nephrology&rft.atitle=Captopril-associated+acute+interstitial+nephritis.&rft.au=Smith%2C+W+R%3BNeill%2C+J%3BCushman%2C+W+C%3BButkus%2C+D+E&rft.aulast=Smith&rft.aufirst=W&rft.date=1989-01-01&rft.volume=9&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=American+journal+of+nephrology&rft.issn=02508095&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-06 N1 - Date created - 1989-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Liquid diet technique of ethanol administration: 1989 update. AN - 79131734; 2667528 AB - A technique of feeding alcohol as part of a liquid diet is reviewed that achieves an alcohol consumption of clinical relevance, while maintaining dietary control and providing adequate nutrition. With this procedure, blood alcohol levels are obtained which mimic clinical conditions and allow experimental duplications of many pathological complications caused by alcohol. In the rat, the liquid diet technique provides a model for the alcoholic fatty liver, various alcohol-induced metabolic, endocrine and central nervous system abnormalities (including tolerance and dependence) and the interaction of ethanol with industrial solvents, many commonly used drugs, analgesics, carcinogens and nutrients. This technique also resulted in the discovery of a new pathway of ethanol metabolism in the microsomes involving an ethanol-specific cytochrome P-450 (P450IIE1), which has now been confirmed in man. P450IIE1 contributes not only to the metabolic tolerance to ethanol, but also explains the enhanced susceptibility of the alcoholic to many ubiquitous xenobiotic agents. The liquid diet technique provides the flexibility to adjust to special experimental or physiological needs by allowing for various substitutions including changes in lipids, proteins or other dietary constituents. This procedure is thereby ideally suited for the study of the interactions of alcohol with deficiency or excess of various nutrients. The technique also facilitates the comparison with controls by simplifying pair feeding procedures. Although the flexibility of the liquid diet technique is one of its key advantages, a standard 'all purpose' liquid diet is described which is appropriate for most experimental applications. In addition, two other general formulae are given, namely a low fat diet (that allows the study of the effects of ethanol in the presence of minimal hepatic lipid accumulation) and a high protein diet (to meet increased needs, e.g. during pregnancy and lactation). The optimal amount of ethanol for the rat liquid diet was found to be 5 g/dl or 36% of total energy. With lesser amounts of alcohol, intake falls below a critical threshold; blood levels of alcohol then become negligible and the model becomes irrelevant to clinical conditions. In the rat, amounts of ethanol above 5 g/dl were not found to be associated with any further gain in alcohol ingestion. By contrast, in the baboon, the ethanol content could be raised profitably to 7 g/dl or 50% of total energy and resulted in the development of cirrhosis. This higher alcohol intake, together with species difference, may explain the greater severity of liver lesions produced by alcohol in the baboon.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Lieber, C S AU - DeCarli, L M AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York 10468. Y1 - 1989 PY - 1989 DA - 1989 SP - 197 EP - 211 VL - 24 IS - 3 SN - 0735-0414, 0735-0414 KW - Dietary Fats KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Nutritional Requirements KW - Animals KW - Liver -- physiopathology KW - Humans KW - Liver Diseases, Alcoholic -- physiopathology KW - Energy Intake KW - Disease Models, Animal KW - Dietary Fats -- administration & dosage KW - Food, Formulated -- analysis KW - Ethanol -- administration & dosage KW - Alcohol Drinking -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79131734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Liquid+diet+technique+of+ethanol+administration%3A+1989+update.&rft.au=Lieber%2C+C+S%3BDeCarli%2C+L+M&rft.aulast=Lieber&rft.aufirst=C&rft.date=1989-01-01&rft.volume=24&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-08 N1 - Date created - 1989-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A multicentre study of vigabatrin for drug-resistant epilepsy. AN - 79127204; 2667606 AB - 1. Vigabatrin (GVG) was given in a single-blind fashion to 89 patients with complex partial seizures (CPS) refractory to conventional drugs. 2. The median number of CPS per month decreased from 11.0 to 5.0 after addition of GVG, and 51% of patients had a 50% or greater decrease in CPS frequency (P less than 0.001). 3. Side effects (principally drowsiness, ataxia, headache) occurred mainly during the initiation of therapy and decreased during therapy. After 12 weeks on GVG side effects significantly interfered with functioning in only 13% of patients, and the efficacy: toxicity ratio warranted continued administration in 74% of patients. 4. Co-administration of GVG resulted in a mean decrease of 20% in phenytoin serum concentration (P less than 0.001). 5. Sixty-six patients having a favourable response to GVG during the single-blind study have been followed for 6-54 (median 33) months on GVG. Only 17 patients have dropped out of long-term follow-up due to break through seizures and/or side effects. No serious systemic or neurological toxicity has been detected. JF - British journal of clinical pharmacology AU - Browne, T R AU - Mattson, R H AU - Penry, J K AU - Smith, D B AU - Treiman, D M AU - Wilder, B J AU - Ben-Menachem, E AU - Miketta, R M AU - Sherry, K M AU - Szabo, G K AD - Department of Neurology, Veterans Administration Medical Center, Boston, MA 02130. Y1 - 1989 PY - 1989 DA - 1989 SP - 95S EP - 100S VL - 27 Suppl 1 SN - 0306-5251, 0306-5251 KW - Aminocaproates KW - 0 KW - Anticonvulsants KW - Phenytoin KW - 6158TKW0C5 KW - Vigabatrin KW - GR120KRT6K KW - Index Medicus KW - Multicenter Studies as Topic KW - Humans KW - Adult KW - Phenytoin -- blood KW - Clinical Trials as Topic KW - Drug Resistance KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Aminocaproates -- pharmacokinetics KW - Anticonvulsants -- pharmacokinetics KW - Anticonvulsants -- adverse effects KW - Aminocaproates -- adverse effects KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Aminocaproates -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79127204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+clinical+pharmacology&rft.atitle=A+multicentre+study+of+vigabatrin+for+drug-resistant+epilepsy.&rft.au=Browne%2C+T+R%3BMattson%2C+R+H%3BPenry%2C+J+K%3BSmith%2C+D+B%3BTreiman%2C+D+M%3BWilder%2C+B+J%3BBen-Menachem%2C+E%3BMiketta%2C+R+M%3BSherry%2C+K+M%3BSzabo%2C+G+K&rft.aulast=Browne&rft.aufirst=T&rft.date=1989-01-01&rft.volume=27+Suppl+1&rft.issue=&rft.spage=95S&rft.isbn=&rft.btitle=&rft.title=British+journal+of+clinical+pharmacology&rft.issn=03065251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Clin Pharmacol. 1989;27 Suppl 1:69S-72S [2757912] Clin Chem. 1982 Jan;28(1):100-4 [6895720] Neurology. 1983 Apr;33(4):414-8 [6403891] Lancet. 1984 Jan 28;1(8370):189-90 [6141335] Ann Neurol. 1985 Mar;17(3):262-6 [3922282] Br J Clin Pharmacol. 1989;27 Suppl 1:101S-107S [2667602] Acta Neurol Scand. 1985 Sep;72(3):295-8 [4061051] Epilepsia. 1986 Mar-Apr;27(2):115-20 [3514204] Epilepsia. 1986 Nov-Dec;27(6):717-23 [3536469] Neurology. 1987 Feb;37(2):184-9 [3808298] Arch Neurol. 1987 Sep;44(9):907-10 [2887152] J Chromatogr. 1985 May 31;341(1):232-8 [4019692] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics of relapse following adolescent substance abuse treatment. AN - 79117418; 2787585 AB - Historically research has focused on the characteristics of adults who relapse following treatment for alcohol or drug dependence. The circumstances of adolescent relapse, however, have largely gone unattended. The present study investigated the relapse rates and characteristics of adolescent posttreatment drug relapse. Seventy-five teens and their parents were interviewed while participating in an adolescent chemical dependency treatment program and at three and six months following treatment. Results indicate that a number of characteristics of adolescent relapse, including rates, are comparable to those of adults. In contrast to adult relapse, adolescent relapses occur most commonly in the presence of social pressure to drink. Situational characteristics of initial relapse experiences were different for transient or minor relapses and adolescent relapses which lead to a return to abusive drinking and drug use patterns. JF - Addictive behaviors AU - Brown, S A AU - Vik, P W AU - Creamer, V A AD - Veterans Administration Medical Center, San Diego, La Jolla, CA. Y1 - 1989 PY - 1989 DA - 1989 SP - 291 EP - 300 VL - 14 IS - 3 SN - 0306-4603, 0306-4603 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Adaptation, Psychological KW - Risk Factors KW - Humans KW - Psychiatric Department, Hospital KW - Follow-Up Studies KW - Adolescent KW - Recurrence KW - Male KW - Female KW - Social Environment KW - Alcoholism -- rehabilitation KW - Marijuana Abuse -- rehabilitation KW - Marijuana Abuse -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79117418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Characteristics+of+relapse+following+adolescent+substance+abuse+treatment.&rft.au=Brown%2C+S+A%3BVik%2C+P+W%3BCreamer%2C+V+A&rft.aulast=Brown&rft.aufirst=S&rft.date=1989-01-01&rft.volume=14&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-25 N1 - Date created - 1989-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Irradiation increases superoxide dismutase in rat intestinal smooth muscle. AN - 79084882; 2744576 AB - We investigated whether X-irradiation could induce the enzyme superoxide dismutase (SOD) in intestinal muscle. Groups of rats received abdominal irradiation and the time course and dose response for SOD activity determined. Jejunal smooth muscle homogenates were analyzed for the activities of copper/zinc (CuZn) and manganese (Mn) SOD activity and for a mitochondrial marker enzyme, citrate synthase. A progressive rise in Mn SOD activity occurred at 20, 46, and 72 h after 1500 R. No significant changes in Cu-Zn SOD activity occurred at any time after 1500 R. At 20 h after 250 R of X-irradiation, Mn SOD activity increased but no further increase occurred at higher irradiation exposures. At the same time, CuZn SOD activity at 20 h after irradiation was greater than controls only at an exposure of 1000 R (p less than 0.05). Using Western blotting, we were able to clearly demonstrate an increase in immunoreactive Mn SOD protein in muscle samples 20 h after 1500 R. The rise in Mn SOD is not simply due to increase in mitochondrial numbers or increase in all mitochondrial enzyme activities because activity of the mitochondrial marker enzyme citrate synthase was decreased after X-irradiation. Transmission electron microscopic studies demonstrated damage to mitochondria after a dose of 3000 R. The data yield evidence that free radicals play a role in irradiation-induced intestinal smooth muscle injury. JF - Free radical biology & medicine AU - Summers, R W AU - Maves, B V AU - Reeves, R D AU - Arjes, L J AU - Oberley, L W AD - Center for Digestive Diseases, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1989 PY - 1989 DA - 1989 SP - 261 EP - 270 VL - 6 IS - 3 SN - 0891-5849, 0891-5849 KW - Manganese KW - 42Z2K6ZL8P KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Citrate (si)-Synthase KW - EC 2.3.3.1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Blotting, Western KW - Mitochondria -- enzymology KW - Kinetics KW - Microscopy, Electron KW - Citrate (si)-Synthase -- metabolism KW - Dose-Response Relationship, Radiation KW - Molecular Weight KW - Male KW - Intestines -- ultrastructure KW - Intestines -- enzymology KW - Muscle, Smooth -- enzymology KW - Superoxide Dismutase -- metabolism KW - Intestines -- radiation effects KW - Muscle, Smooth -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79084882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Irradiation+increases+superoxide+dismutase+in+rat+intestinal+smooth+muscle.&rft.au=Summers%2C+R+W%3BMaves%2C+B+V%3BReeves%2C+R+D%3BArjes%2C+L+J%3BOberley%2C+L+W&rft.aulast=Summers&rft.aufirst=R&rft.date=1989-01-01&rft.volume=6&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of prostaglandins in alcohol teratogenesis. AN - 79077205; 2742275 JF - Annals of the New York Academy of Sciences AU - Randall, C L AU - Anton, R F AU - Becker, H C AU - White, N M AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1989 PY - 1989 DA - 1989 SP - 178 EP - 182 VL - 562 SN - 0077-8923, 0077-8923 KW - Prostaglandin Antagonists KW - 0 KW - Prostaglandins KW - Ethanol KW - 3K9958V90M KW - Aspirin KW - R16CO5Y76E KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Prostaglandin Antagonists -- pharmacology KW - Mice KW - Aspirin -- pharmacology KW - Female KW - Pregnancy KW - Indomethacin -- pharmacology KW - Pregnancy, Animal -- metabolism KW - Ethanol -- toxicity KW - Abnormalities, Drug-Induced -- etiology KW - Prostaglandins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79077205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Role+of+prostaglandins+in+alcohol+teratogenesis.&rft.au=Randall%2C+C+L%3BAnton%2C+R+F%3BBecker%2C+H+C%3BWhite%2C+N+M&rft.aulast=Randall&rft.aufirst=C&rft.date=1989-01-01&rft.volume=562&rft.issue=&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-28 N1 - Date created - 1989-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of chronic vanadate ingestion on amino acid and water absorption in rat intestine. AN - 79074263; 2742498 AB - Chronic administration of a relatively low concentration of vanadate to rats causes inhibition of water, alpha-aminoisobutyric acid (AIB) and L-alanine absorption. The mechanism responsible for this inhibition was tested by studying the uptake of alanine in isolated rat intestinal cells. The studies suggest that the vanadate inhibition of amino acid transport is primarily caused by a decreased activity of the Na+-K+ pump, an action that is similar to what is observed when the rat intestine is acutely exposed to vanadate. Vanadate appeared to have no direct effect on the entry of amino acids into the intestinal cell. This was evident by the fact that amino acid uptake by enterocytes of control rats was not different from the uptake by cells of vanadate-treated animals that have an inwardly directed Na gradient artificially created across them. Furthermore, 86RB influx and efflux into and out of intestinal tissues of the vanadate-treated animals were, respectively, decreased and increased as compared to normal control tissues and they were similar to what is observed when the intestine is acutely exposed to ouabain, a known specific inhibitor of the Na+-K+ pump. JF - Archives of toxicology AU - Hajjar, J J AU - Dobish, M P AU - Tomicic, T K AD - Department of Medicine, Veterans Administration Medical Center, Newington, CT 06111. Y1 - 1989 PY - 1989 DA - 1989 SP - 29 EP - 33 VL - 63 IS - 1 SN - 0340-5761, 0340-5761 KW - Amino Acids KW - 0 KW - Rubidium Radioisotopes KW - Water KW - 059QF0KO0R KW - Vanadates KW - 3WHH0066W5 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Jejunum -- drug effects KW - Intestinal Absorption KW - Jejunum -- cytology KW - Female KW - Jejunum -- metabolism KW - Vanadates -- toxicity KW - Amino Acids -- pharmacokinetics KW - Water -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79074263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Effect+of+chronic+vanadate+ingestion+on+amino+acid+and+water+absorption+in+rat+intestine.&rft.au=Hajjar%2C+J+J%3BDobish%2C+M+P%3BTomicic%2C+T+K&rft.aulast=Hajjar&rft.aufirst=J&rft.date=1989-01-01&rft.volume=63&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-10 N1 - Date created - 1989-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Zinc acetate pretreatment ameliorates cisplatin-induced Sertoli cell dysfunction in Sprague-Dawley rats. AN - 79038424; 2500265 AB - The present study was undertaken to determine if prior administration of zinc acetate (ZnAc) or copper sulfate (CuSO4) could prevent pituitary, Leydig, or Sertoli cell dysfunction subsequent to cisplatin administration in adult Sprague-Dawley rats. Animals were given cisplatin at a dose of 2 mg/kg daily for 5 days, with or without the i.p. administration of ZnAc (6 mg/kg per day) or CuSO4 (5 mg/kg per day), beginning 5 days prior to and continuing through the administration of cisplatin. Control animals were given vehicle, ZnAc1, or CuSO4. Animals were sacrificed 1 week after the initial cisplatin injection. Cisplatin administration resulted in suppressed serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels as well as a 77% reduction in serum testosterone and an 82% reduction in testicular testosterone. The concomitant administration of either ZnAc or CuSO4 did not result in a significant difference relative to animals receiving cisplatin alone, although administration of both cations alone significantly reduced testicular testosterone content. Serum androgen-binding protein (ABP) was not significantly lowered in any treatment group. There was a marked reduction of 57% in testicular ABP content relative to control values subsequent to cisplatin administration. This reduction was partially prevented by ZnAc treatment: the testicular ABP concentration was only 15% lower than that in controls (not significant). Since the cisplatin-induced reduction in serum FSH was not altered by ZnAc pretreatment, we conclude that the near normalization of testicular ABP content may be evidence of improved Sertoli cell function. In contrast, cisplatin-induced decreases in the serum gonadotropins and testicular androgens were not lessened by pretreatment with either cation. Further studies may be warranted to determine whether ZnAc pretreatment has a beneficial effect on spermatogenesis during cisplatin treatment. JF - Cancer chemotherapy and pharmacology AU - Pogach, L M AU - Lee, Y AU - Giglio, W AU - Naumoff, M AU - Huang, H F AD - Department of Medicine, East Orange Veterans Administration Medical Center, NJ 07019. Y1 - 1989 PY - 1989 DA - 1989 SP - 177 EP - 180 VL - 24 IS - 3 SN - 0344-5704, 0344-5704 KW - Acetates KW - 0 KW - Androgen-Binding Protein KW - Testosterone KW - 3XMK78S47O KW - Copper KW - 789U1901C5 KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Copper Sulfate KW - LRX7AJ16DT KW - Cisplatin KW - Q20Q21Q62J KW - Acetic Acid KW - Q40Q9N063P KW - Index Medicus KW - Animals KW - Drug Interactions KW - Pituitary Gland -- cytology KW - Copper -- pharmacology KW - Leydig Cells -- drug effects KW - Follicle Stimulating Hormone -- blood KW - Pituitary Gland -- drug effects KW - Rats KW - Luteinizing Hormone -- blood KW - Testosterone -- analysis KW - Time Factors KW - Male KW - Sertoli Cells -- drug effects KW - Rats, Inbred Strains -- physiology KW - Cisplatin -- toxicity KW - Androgen-Binding Protein -- blood KW - Acetates -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79038424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Zinc+acetate+pretreatment+ameliorates+cisplatin-induced+Sertoli+cell+dysfunction+in+Sprague-Dawley+rats.&rft.au=Pogach%2C+L+M%3BLee%2C+Y%3BGiglio%2C+W%3BNaumoff%2C+M%3BHuang%2C+H+F&rft.aulast=Pogach&rft.aufirst=L&rft.date=1989-01-01&rft.volume=24&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-02 N1 - Date created - 1989-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic alkalosis induced by regional citrate hemodialysis. AN - 79034624; 2730806 AB - Two patients are described in whom regional citrate dialysis (RCD) and induced metabolic alkalosis with marked increases in serum HCO3, which were sustained during the period of repeated treatments. As currently employed, RCD of necessity delivers large amounts of potential bicarbonate (several hundred mEq) to the patient and may cause severe metabolic alkalosis. Studies should be carried out to determine an effective method to avoid this complication whenever repeated RCD is necessary or is used in patients with pre-existing alkalosis. JF - ASAIO transactions AU - Silverstein, F J AU - Oster, J R AU - Perez, G O AU - Materson, B J AU - Lopez, R A AU - Al-Reshaid, K AD - Medical and Research Services, Veterans Administration Medical Center, Miami, FL 33125. PY - 1989 SP - 22 EP - 25 VL - 35 IS - 1 SN - 0889-7190, 0889-7190 KW - Bicarbonates KW - 0 KW - Citrates KW - Dialysis Solutions KW - Hemodialysis Solutions KW - Citric Acid KW - 2968PHW8QP KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Renal Dialysis -- adverse effects KW - Alkalosis -- etiology KW - Dialysis Solutions -- adverse effects KW - Hemodialysis Solutions -- adverse effects KW - Citrates -- adverse effects KW - Bicarbonates -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79034624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASAIO+transactions&rft.atitle=Metabolic+alkalosis+induced+by+regional+citrate+hemodialysis.&rft.au=Silverstein%2C+F+J%3BOster%2C+J+R%3BPerez%2C+G+O%3BMaterson%2C+B+J%3BLopez%2C+R+A%3BAl-Reshaid%2C+K&rft.aulast=Silverstein&rft.aufirst=F&rft.date=1989-01-01&rft.volume=35&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=ASAIO+transactions&rft.issn=08897190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-14 N1 - Date created - 1989-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The benzodiazepine receptor inverse agonist RO15-4513 exacerbates, but does not precipitate, ethanol withdrawal in mice. AN - 79034096; 2543989 AB - RO15-4513, an imidazobenzodiazepine that has been reported to antagonize several behavioral and biochemical actions of ethanol, was given to C3H mice at various times during withdrawal from chronic (72 hours) continuous exposure to ethanol vapor. When administered immediately following chronic ethanol exposure, RO15-4513 (6 or 12 mg/kg) did not influence the withdrawal response. However, when given at subsequent times (3, 5, and 8 hours postethanol withdrawal), RO15-4513 significantly increased the severity of the withdrawal response in ethanol-exposed mice. Moreover, this exacerbation was completely reversed by pretreatment with the benzodiazepine receptor antagonist RO15-1788. Thus, these data indicate that the benzodiazepine inverse agonist, RO15-4513, is capable of exacerbating, but not precipitating, ethanol withdrawal. JF - Pharmacology, biochemistry, and behavior AU - Becker, H C AU - Anton, R F AD - Veterans Administration Medical Center, Charleston, SC. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 163 EP - 167 VL - 32 IS - 1 SN - 0091-3057, 0091-3057 KW - Affinity Labels KW - 0 KW - Azides KW - Receptors, GABA-A KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Ro 15-4513 KW - 91917-65-6 KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Mice, Inbred C3H KW - Mice KW - Male KW - Acoustic Stimulation -- adverse effects KW - Ethanol -- adverse effects KW - Affinity Labels -- pharmacology KW - Substance Withdrawal Syndrome KW - Azides -- pharmacology KW - Receptors, GABA-A -- drug effects KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79034096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=The+benzodiazepine+receptor+inverse+agonist+RO15-4513+exacerbates%2C+but+does+not+precipitate%2C+ethanol+withdrawal+in+mice.&rft.au=Becker%2C+H+C%3BAnton%2C+R+F&rft.aulast=Becker&rft.aufirst=H&rft.date=1989-01-01&rft.volume=32&rft.issue=1&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-17 N1 - Date created - 1989-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Self-efficacy in alcoholics: clinical validation of the Situational Confidence Questionnaire. AN - 79025766; 2728959 AB - Recent theory and empirical data suggest that self efficacy plays an important role in resistance to relapse for substance abusers. This study investigated the validity of the Situational Confidence Questionnaire (SCQ), a new instrument designed to measure self-efficacy expectations in purported high-risk drinking situations. The SCQ was administered to 46 short-term sober (STS) and 25 long-term sober (LTS) alcoholics. STS subjects were newly admitted alcohol treatment patients and LTS subjects had been abstinent for at least one year. Results indicated significantly higher self efficacy for LTS subjects than for STS subjects on total score and on 7 of the 8 subscales (p less than .001). Stepwise discriminant analysis yielded a linear combination of three subscales to account for 49% of the total variance; 92% of the LTS and 65% of the STS subjects were correctly identified by the classification function. These results extended earlier work with the SCQ using newly sober subjects and, in addition, provide encouraging validity data for the SCQ. JF - Addictive behaviors AU - Miller, P J AU - Ross, S M AU - Emmerson, R Y AU - Todt, E H AD - Psychology Service, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1989 PY - 1989 DA - 1989 SP - 217 EP - 224 VL - 14 IS - 2 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Humans KW - Interpersonal Relations KW - Psychometrics KW - Alcoholism -- rehabilitation KW - Self Concept KW - Personality Tests KW - Alcoholism -- psychology KW - Social Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79025766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Self-efficacy+in+alcoholics%3A+clinical+validation+of+the+Situational+Confidence+Questionnaire.&rft.au=Miller%2C+P+J%3BRoss%2C+S+M%3BEmmerson%2C+R+Y%3BTodt%2C+E+H&rft.aulast=Miller&rft.aufirst=P&rft.date=1989-01-01&rft.volume=14&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intergradation of two different venom populations of the Mojave rattlesnake (Crotalus scutulatus scutulatus) in Arizona. AN - 79004186; 2499081 AB - Two distinct venom populations of Crotalus scutulatus scutulatus exist in Arizona. The venom of one population (venom A) contains the toxin 'Mojave toxin' and is lacking in hemorrhagic and specific proteolytic activities. The other population (venom B) does not contain Mojave toxin but does produce hemorrhagic and proteolytic activities. The venoms of 15 Crotalus scutulatus scutulatus from regions between the venom A and venom B populations in Arizona were examined for the presence of Mojave toxin by immunochemical assay, lethality by mouse i.p. LD50, proteolytic activity and hemorrhagic activity in mice. Venom protein constituents were analyzed using reverse-phase HPLC. Seven venoms contained both the Mojave toxin of venom A and the proteolytic and hemorrhagic activities of venom B. The i.p. LD50 values of the A + B venoms were 0.4-2.6 mg/kg, compared to 0.2-0.5 mg/kg for venom A individuals and 2.1-5.3 mg/kg for the venom B individuals. HPLC illustrated that the A + B venoms exhibited a combined protein profile of venom A and venom B. These data indicate that an intergrade zone exists between the two venom types which arcs around the western and southern regions of the venom B population. Within these regions, three major venom types can occur in Crotalus s. scutulatus. JF - Toxicon : official journal of the International Society on Toxinology AU - Glenn, J L AU - Straight, R C AD - Venom Research Laboratory, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1989 PY - 1989 DA - 1989 SP - 411 EP - 418 VL - 27 IS - 4 SN - 0041-0101, 0041-0101 KW - Crotalid Venoms KW - 0 KW - Peptide Hydrolases KW - EC 3.4.- KW - Index Medicus KW - Animals KW - Peptide Hydrolases -- analysis KW - Immunodiffusion KW - Hemorrhage -- chemically induced KW - Electrophoresis, Polyacrylamide Gel KW - Arizona KW - Mice KW - Molecular Weight KW - Chromatography, High Pressure Liquid KW - Crotalid Venoms -- toxicity KW - Crotalid Venoms -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79004186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Intergradation+of+two+different+venom+populations+of+the+Mojave+rattlesnake+%28Crotalus+scutulatus+scutulatus%29+in+Arizona.&rft.au=Glenn%2C+J+L%3BStraight%2C+R+C&rft.aulast=Glenn&rft.aufirst=J&rft.date=1989-01-01&rft.volume=27&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-29 N1 - Date created - 1989-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical utility of a Bayesian dosing program for phenytoin. AN - 78993849; 2728087 AB - We performed two studies to assess the clinical utility of a Bayesian regression analysis computer program for phenytoin (PHT). In a randomized prospective study of 40 epileptic patients, the dosing program was significantly more accurate (p = 0.002) and less biased (p = 0.02) than a group of physicians at hitting a target PHT serum-concentration. Initial serum PHT concentrations that were not steady state were associated with the largest dosing errors by physicians but did not affect the accuracy of the dosing program. In a second study, we used the dosing program to predict 91 serum concentrations in 31 patients with PHT toxicity after the drug was stopped (initial concentration 26-69 micrograms/ml). The program predicted serum concentrations with a mean error of 3.49 +/- 0.29 micrograms/ml without significant tendency to over- or underpredict. We conclude that this dosing program may aid clinicians by improving dosing accuracy and predicting serum concentrations in patients with PHT toxicity. JF - Therapeutic drug monitoring AU - Privitera, M D AU - Homan, R W AU - Ludden, T M AU - Peck, C C AU - Vasko, M R AD - Department of Neurology, Veterans Administration Medical Center, Dallas, Texas. Y1 - 1989 PY - 1989 DA - 1989 SP - 285 EP - 294 VL - 11 IS - 3 SN - 0163-4356, 0163-4356 KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Software KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Probability KW - Phenytoin -- pharmacokinetics KW - Bayes Theorem KW - Phenytoin -- adverse effects KW - Phenytoin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78993849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Clinical+utility+of+a+Bayesian+dosing+program+for+phenytoin.&rft.au=Privitera%2C+M+D%3BHoman%2C+R+W%3BLudden%2C+T+M%3BPeck%2C+C+C%3BVasko%2C+M+R&rft.aulast=Privitera&rft.aufirst=M&rft.date=1989-01-01&rft.volume=11&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=01634356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-29 N1 - Date created - 1989-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cognitive and behavioral features of adolescent coping in high-risk drinking situations. AN - 78987666; 2718823 AB - The present study examined the coping responses used by adolescents in high-risk situations. Sixty-six adolescents described situations in which it was difficult to resist drinking alcohol. Cognitive and behavioral responses in the perceived high-risk alcohol situations were examined. Abusing and nonabusing adolescents reported similar high-risk situations, but differed significantly in the cognitive and behavioral strategies used to cope with drinking pressures. Cognitive strategies associated with abstaining from alcohol use included defining oneself as a nondrinker and viewing other drinkers negatively. Behavioral responses associated with not drinking included engaging in an alternative activity and avoiding or limiting direct exposure to the high-risk situations. Theoretical and clinical implications for effective coping in alcohol situations are discussed. JF - Addictive behaviors AU - Brown, S A AU - Stetson, B A AU - Beatty, P A AD - Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1989 PY - 1989 DA - 1989 SP - 43 EP - 52 VL - 14 IS - 1 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Demography KW - Risk KW - Humans KW - Adult KW - Child KW - Parents KW - Adolescent KW - Alcoholism -- psychology KW - Male KW - Female KW - Social Environment KW - Adolescent Behavior KW - Adaptation, Psychological KW - Alcohol Drinking -- psychology KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78987666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Cognitive+and+behavioral+features+of+adolescent+coping+in+high-risk+drinking+situations.&rft.au=Brown%2C+S+A%3BStetson%2C+B+A%3BBeatty%2C+P+A&rft.aulast=Brown&rft.aufirst=S&rft.date=1989-01-01&rft.volume=14&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-20 N1 - Date created - 1989-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phase II trial of fenretinide [N-(4-hydroxyphenyl) retinamide] in myelodysplasia: possible retinoid-induced disease acceleration. AN - 78980708; 2523991 AB - To determine the activity of fenretinide in patients with myelodysplastic syndromes, 15 patients were treated (300 mg/d starting dose, escalated to 400 mg/d) for a 12-week course. No responses were observed in 14 evaluable patients. Exacerbation of thrombocytopenia occurred in one patient with chronic myelomonocytic leukemia, who succumbed to an intracerebral hemorrhage after 3 weeks of treatment. Two patients with long-standing stable sideroblastic anemia experienced interval leukemic progression. In one patient, clinical features of chronic myelomonocytic leukemia appeared, characterized by a striking rise in peripheral monocyte count (0.49 x 10(9)/l to 10.8 x 10(9)/l) and hepatosplenomegaly, which resolved promptly after cessation of treatment. The second patient experienced evolution into acute myelomonocytic leukemia with cytogenetic progression. The drug was well tolerated with no patient having to discontinue treatment because of toxicity. We conclude that fenretinide lacks clinical efficacy in the treatment of myelodysplasia and in some patients may enhance leukemic progression. JF - Leukemia research AU - Garewal, H S AU - List, A AU - Meyskens, F AU - Buzaid, A AU - Greenberg, B AU - Katakkar, S AD - Section of Hematology/Oncology, Veterans Administration Medical Centers, Tucson, AZ 85723. Y1 - 1989 PY - 1989 DA - 1989 SP - 339 EP - 343 VL - 13 IS - 4 SN - 0145-2126, 0145-2126 KW - Fenretinide KW - 187EJ7QEXL KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Acute Disease KW - Drug Evaluation KW - Cerebral Hemorrhage -- chemically induced KW - Leukemia -- chemically induced KW - Leukocytosis -- chemically induced KW - Humans KW - Thrombocytopenia -- chemically induced KW - Aged KW - Middle Aged KW - Monocytes KW - Male KW - Tretinoin -- analogs & derivatives KW - Myelodysplastic Syndromes -- drug therapy KW - Myelodysplastic Syndromes -- pathology KW - Myelodysplastic Syndromes -- blood KW - Tretinoin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78980708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+research&rft.atitle=Phase+II+trial+of+fenretinide+%5BN-%284-hydroxyphenyl%29+retinamide%5D+in+myelodysplasia%3A+possible+retinoid-induced+disease+acceleration.&rft.au=Garewal%2C+H+S%3BList%2C+A%3BMeyskens%2C+F%3BBuzaid%2C+A%3BGreenberg%2C+B%3BKatakkar%2C+S&rft.aulast=Garewal&rft.aufirst=H&rft.date=1989-01-01&rft.volume=13&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Leukemia+research&rft.issn=01452126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amoxapine-induced neuroleptic malignant syndrome. AN - 78980139; 2718483 AB - Amoxapine is a second-generation antidepressant possessing significant dopamine-blocking activity and extra-pyramidal side effects. The occurrence of neuroleptic malignant syndrome is described in a patient treated with amoxapine. The syndrome resolved rapidly following discontinuation of the drug. Older patients may be particularly at risk for this adverse reaction with amoxapine. JF - DICP : the annals of pharmacotherapy AU - Madakasira, S AD - Psychiatry Service, Veterans Administration Medical Center, Dayton, OH 45428. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 50 EP - 1, 55 VL - 23 IS - 1 SN - 1042-9611, 1042-9611 KW - Dibenzoxazepines KW - 0 KW - Amoxapine KW - R63VQ857OT KW - Index Medicus KW - Humans KW - Bipolar Disorder -- drug therapy KW - Middle Aged KW - Female KW - Dibenzoxazepines -- adverse effects KW - Neuroleptic Malignant Syndrome -- etiology KW - Amoxapine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78980139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DICP+%3A+the+annals+of+pharmacotherapy&rft.atitle=Amoxapine-induced+neuroleptic+malignant+syndrome.&rft.au=Madakasira%2C+S&rft.aulast=Madakasira&rft.aufirst=S&rft.date=1989-01-01&rft.volume=23&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=DICP+%3A+the+annals+of+pharmacotherapy&rft.issn=10429611&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-16 N1 - Date created - 1989-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of the brain to blood transport system for enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking ethanol. AN - 78974157; 2566312 AB - Enkephalin concentrations in the brain correlate inversely with ethanol intake and the predisposition of different strains of mice to drink. This and other evidence link ethanol ingestion, addiction, and withdrawal to opiate peptides. We studied the effect of these conditions on the saturable, stereospecific system that transports the enkephalins and Tyr-MIF-1 (a peptide with antiopiate action) out of the brain. The transport rate in mice physically dependent on ethanol was only 56% of the rate in control mice, but during withdrawal from ethanol transport rates increased to levels seen in controls. Transport rates were also lower in strains of mice previously determined to have lower enkephalin concentrations in the brain and to be predisposed to drinking ethanol. Acute intraperitoneal or intracerebroventricular injection of ethanol had minimal direct effects on the transport rate, suggesting that it is not ethanol itself, but those factors associated with addiction and the predisposition to drink ethanol, that altered transport. These studies raise the possibility that the inhibition of this system that transports enkephalins/Tyr-MIF-1 out of the brain might offer a new approach to the control of drinking and withdrawal from ethanol. JF - Alcohol (Fayetteville, N.Y.) AU - Banks, W A AU - Kastin, A J AD - Veterans Administration Medical Center, New Orleans, LA. PY - 1989 SP - 53 EP - 57 VL - 6 IS - 1 SN - 0741-8329, 0741-8329 KW - Enkephalins KW - 0 KW - Ethanol KW - 3K9958V90M KW - tyrosyl-prolyl-leucyl-glycinamide KW - 77133-61-0 KW - MSH Release-Inhibiting Hormone KW - 9083-38-9 KW - Index Medicus KW - Mice, Inbred Strains KW - Biological Transport, Active -- drug effects KW - Animals KW - Body Weight -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Species Specificity KW - Male KW - Organ Size -- drug effects KW - Mice, Inbred DBA KW - MSH Release-Inhibiting Hormone -- metabolism KW - MSH Release-Inhibiting Hormone -- analogs & derivatives KW - Ethanol -- pharmacology KW - Enkephalins -- blood KW - Brain -- drug effects KW - MSH Release-Inhibiting Hormone -- blood KW - Enkephalins -- metabolism KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78974157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Inhibition+of+the+brain+to+blood+transport+system+for+enkephalins+and+Tyr-MIF-1+in+mice+addicted+or+genetically+predisposed+to+drinking+ethanol.&rft.au=Banks%2C+W+A%3BKastin%2C+A+J&rft.aulast=Banks&rft.aufirst=W&rft.date=1989-01-01&rft.volume=6&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-27 N1 - Date created - 1989-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Loss of muscarinic and benzodiazepine neuroreceptors from hippocampus of alcohol abusers. AN - 78970464; 2541736 AB - Thiamine deficiency (Wernicke-Korsakoff's disease) may not be the only mechanism whereby chronic alcohol abuse affects the brain and not all alcohol-related changes may be evident morphologically. The purpose of this study was to determine if alcohol abuse affects muscarinic cholinergic and benzodiazepine receptors in the hippocampus of histologically normal brains obtained at autopsy in a general hospital population. Because patients were excluded who had significant brain atrophy and/or dementia severe enough to require institutionalization, the reported findings are presumed to be early changes in the development of an alcohol encephalopathy. In addition, patients were excluded from this study if they had clinical brain diseases (including Wernicke's disease), died in coma, had liver disease, or received medications that could potentially alter receptor binding. The reported changes in receptor binding were therefore presumed to be related to alcohol abuse per se and not an alcohol-associated condition. We found that muscarinic cholinergic synaptic receptor density determined with 3[H] quinuclidinyl benzilate was decreased by 30% in homogenates of the hippocampus of 25 alcohol abusers compared with 25 matched nonalcoholic controls. Similarly, densities of benzodiazepine receptors determined with 3[H] flunitrazepam were also decreased by approximately 30% in alcohol abusers. The affinities of both receptor types were not affected by alcohol abuse. Age and death-autopsy time interval had no significant effects on either wet tissue protein concentrations, yields of protein after centrifugation, or receptor binding. The contributions of age and time interval were each less than 2% of the total variance of protein concentrations and receptor binding.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcohol (Fayetteville, N.Y.) AU - Freund, G AU - Ballinger, W E AD - Medical Service Veterans Administration Medical Center, Gainesville, FL 32602. PY - 1989 SP - 23 EP - 31 VL - 6 IS - 1 SN - 0741-8329, 0741-8329 KW - Nerve Tissue Proteins KW - 0 KW - Receptors, GABA-A KW - Receptors, Muscarinic KW - Flunitrazepam KW - 620X0222FQ KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Index Medicus KW - Aging -- metabolism KW - Humans KW - In Vitro Techniques KW - Binding, Competitive KW - Nerve Tissue Proteins -- metabolism KW - Flunitrazepam -- metabolism KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Hippocampus -- metabolism KW - Hippocampus -- cytology KW - Receptors, Muscarinic -- drug effects KW - Alcoholism -- metabolism KW - Receptors, GABA-A -- drug effects KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78970464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Loss+of+muscarinic+and+benzodiazepine+neuroreceptors+from+hippocampus+of+alcohol+abusers.&rft.au=Freund%2C+G%3BBallinger%2C+W+E&rft.aulast=Freund&rft.aufirst=G&rft.date=1989-01-01&rft.volume=6&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-27 N1 - Date created - 1989-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Self-help approaches to smoking cessation: a report from the normative aging study. AN - 78955887; 2718821 AB - Self-quitters make up by far the largest proportion of ex-cigarette smokers, yet this population has not been extensively characterized to date. We compared male self-quitters (N = 191) and age-matched recidivists (N = 110) on smoking histories, psychosocial attributes and quitting methods. A number of significant relationships were found, some of which may have clinical implications. those who substituted cigars or pipes for cigarettes were nearly four times more likely to be successful, and those who reported consuming more food/snacks after quitting were 80% more likely to be successful quitters. Subjects who reported using no coping strategies in former smoking settings after cessation because they had no urges to smoke in these settings were also much more likely to be successful quitters. Recidivists were more likely to report using physical activity as a means of coping with temptations to smoke, and were somewhat older at the time of the quit attempt. Withdrawal symptoms and psychosocial stress were reported as reasons for relapse by early relapsers, while late relapsers reported being around other smokers on social occasions, and psychosocial stress. JF - Addictive behaviors AU - Garvey, A J AU - Heinold, J W AU - Rosner, B AD - Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108. Y1 - 1989 PY - 1989 DA - 1989 SP - 23 EP - 33 VL - 14 IS - 1 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Demography KW - Substance Withdrawal Syndrome KW - Humans KW - Prognosis KW - Middle Aged KW - Statistics as Topic KW - Male KW - Smoking -- therapy KW - Smoking -- psychology KW - Self Care -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78955887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Self-help+approaches+to+smoking+cessation%3A+a+report+from+the+normative+aging+study.&rft.au=Garvey%2C+A+J%3BHeinold%2C+J+W%3BRosner%2C+B&rft.aulast=Garvey&rft.aufirst=A&rft.date=1989-01-01&rft.volume=14&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-20 N1 - Date created - 1989-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic interaction of cefotaxime and its metabolite desacetylcefotaxime demonstrated by drug-impregnated disks. AN - 78933338; 2653715 AB - Because no simple in vitro test for cefotaxime (CTX) and desacetylcefotaxime (dCTX) synergy exists, and, because no disk susceptibility data is available for dCTX, we investigated the potential of antibiotic impregnated disks as a test for positive in vitro interaction. Results of this study indicate that all strains of Staphylococcus aureus tested demonstrated additive interactions using disks that contained 30 micrograms of dCTX. In contrast, it was necessary to use much smaller concentrations of each cephalosporin to demonstrate additive effects against Gram-negative bacteria. Zones of inhibition were greater for disks containing the combination compared to either CTX or dCTX alone, among all the Gram-negative genera tested; however, these differences were statistically significant only for Klebsiella pneumoniae and Escherichia coli (P less than 0.05). These results demonstrate that disk susceptibility testing is reliable for the CTX metabolite, dCTX, and suggests that this technique using disks impregnated with CTX and dCTX singly and in combination is a simple method with which to evaluate positive antimicrobial interactions in the clinical laboratory. JF - Diagnostic microbiology and infectious disease AU - Stevens, D L AU - Bergstrom, R AU - Gibbons, A AD - Infectious Disease Section, Veterans Administration Medical Center, Boise, Idaho 82702. PY - 1989 SP - 73 EP - 80 VL - 12 IS - 1 SN - 0732-8893, 0732-8893 KW - desacetylcefotaxime KW - 6E65O1Y1P8 KW - Cefotaxime KW - N2GI8B1GK7 KW - Index Medicus KW - Enterobacter -- drug effects KW - Penicillin Resistance KW - Klebsiella pneumoniae -- drug effects KW - Humans KW - Serratia marcescens -- drug effects KW - Escherichia coli -- drug effects KW - Drug Therapy, Combination -- pharmacology KW - Drug Synergism KW - Cefotaxime -- analogs & derivatives KW - Microbial Sensitivity Tests -- methods KW - Staphylococcus aureus -- drug effects KW - Cefotaxime -- pharmacology KW - Gram-Negative Bacteria -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78933338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+microbiology+and+infectious+disease&rft.atitle=Synergistic+interaction+of+cefotaxime+and+its+metabolite+desacetylcefotaxime+demonstrated+by+drug-impregnated+disks.&rft.au=Stevens%2C+D+L%3BBergstrom%2C+R%3BGibbons%2C+A&rft.aulast=Stevens&rft.aufirst=D&rft.date=1989-01-01&rft.volume=12&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-12 N1 - Date created - 1989-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Marital and family therapy in alcoholism treatment. AN - 78922366; 2651683 AB - This synopsis of the outcome literature on marital and family treatment (MFT) drew three conclusions. First, intervening at the marital/family level with nonalcoholic family members can motivate an initial commitment to change in the alcoholic who is unwilling to seek help. Second, MFT alone, or with individual alcoholism treatment, produces better marital and/or drinking outcomes during the 6 months following treatment entry than methods that don't involve the spouse or other family members. The most promising MFT approach is behavioral marital therapy (BMT) that combines a focus on the drinking with work on other marital relationship issues via direct instigation of positive couple/family activities and teaching of communication and conflict resolution skills. Two BMT alcohol-focused methods have been used: a behavioral contract between alcoholic and spouse to maintain disulfiram ingestion; and "Alcohol-Focused Spouse Involvement," which rearranges reinforcement contingencies to decrease family behaviors that trigger or enable drinking and to increase positive reinforcement for sobriety. Third, studies of long-term maintenance suggest that BMT with an alcohol and relationship focus may reduce marital and/or drinking deterioration better than individual methods during long-term recovery. The following recommendations were made when to intervene at the level of the individual alcoholic only, at the marital/family level, or at both the individual and marital/family levels: (a) Intervene only at the individual level when the alcoholic refuses consent to contact family members or the family refuses involvement. (b) Include adult family members who live with the alcoholic in the assessment process for all who consent.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of substance abuse treatment AU - O'Farrell, T J AD - Alcohol and Family Studies Laboratory, Veterans Administration Medical Center, Brockton, MA 02401. Y1 - 1989 PY - 1989 DA - 1989 SP - 23 EP - 29 VL - 6 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Humans KW - Family KW - Marital Therapy -- methods KW - Alcoholism -- rehabilitation KW - Family Therapy -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78922366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Marital+and+family+therapy+in+alcoholism+treatment.&rft.au=O%27Farrell%2C+T+J&rft.aulast=O%27Farrell&rft.aufirst=T&rft.date=1989-01-01&rft.volume=24&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-06 N1 - Date created - 1989-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Identification of the alcoholic schizophrenic: use of clinical laboratory tests and the MAST. AN - 78916959; 2927122 AB - A screening procedure to identify alcohol abuse among schizophrenics is sorely needed. We evaluated the utility of a particular screening battery that consisted of three standard clinical laboratory tests (GGTP, MCV, SGOT) and the Michigan Alcoholism Screening Test (MAST). Consecutive admissions to an acute psychiatric unit and to an alcohol rehabilitation program were initially evaluated for inclusion in three diagnostic groupings: alcoholic schizophrenics, nonalcoholic schizophrenics and nonschizophrenic alcoholics. Twenty inpatient veterans were selected for each diagnostic group. These groups were then compared in terms of scores on the GGTP, MCV, SGOT and MAST. The MAST had the greatest sensitivity, but suffered low specificity. The GGTP demonstrated excellent specificity, but very poor sensitivity. When multiple tests were considered, the combination of the MAST and GGTP proved the best at identifying alcohol abuse in schizophrenics. The false positive rate was unacceptably high, however. The test battery was not useful in discriminating between nonalcoholic schizophrenics and alcoholic schizophrenics, yet could distinguish the nonschizophrenic alcoholics from the two schizophrenic groups. JF - Journal of studies on alcohol AU - Toland, A M AU - Moss, H B AD - Department of Psychology, Veterans Administration Medical Center, Pittsburgh, Pennsylvania 15206. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 49 EP - 53 VL - 50 IS - 1 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Adult KW - Schizophrenic Psychology KW - Middle Aged KW - Liver Function Tests KW - Male KW - Psychological Tests KW - Manuals as Topic KW - Alcoholism -- diagnosis KW - Schizophrenia -- diagnosis KW - Schizophrenia -- complications KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78916959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Identification+of+the+alcoholic+schizophrenic%3A+use+of+clinical+laboratory+tests+and+the+MAST.&rft.au=Toland%2C+A+M%3BMoss%2C+H+B&rft.aulast=Toland&rft.aufirst=A&rft.date=1989-01-01&rft.volume=50&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-11 N1 - Date created - 1989-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholics Anonymous: membership characteristics and effectiveness as treatment. AN - 78900760; 2648497 AB - Reports published since 1976 were reviewed with respect to the characteristics of alcohol-dependent individuals who affiliate with Alcoholics Anonymous (AA). No "AA personality" was identified inasmuch as systematic differences have not been observed between affiliates and nonaffiliates. Evaluation studies were reviewed with regard to data on AA's effectiveness as treatment, leading to several observations. When "alcoholics" participate in AA in addition to professional treatment, their outcome on drinking and other indices is no worse, and may be better, than that of patients who do not involve themselves in AA. AA involvement tends to be associated with relatively high abstinence rates but with only fairly typical total improvement rates. The effectiveness of AA as compared to other treatments for "alcoholism" has yet to be demonstrated. Reliable guidelines have not been established for predicting who among AA members will be successful. An alcohol-involved person's chances of participating in AA are related to the type of drinking outcome achieved. Caution was raised against rigidly referring every alcohol-troubled person to AA. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Emrick, C D AD - Psychology Service, Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1989 PY - 1989 DA - 1989 SP - 37 EP - 53 VL - 7 SN - 0738-422X, 0738-422X KW - Index Medicus KW - Humans KW - Prognosis KW - Alcoholism -- rehabilitation KW - Alcoholics Anonymous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78900760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Alcoholics+Anonymous%3A+membership+characteristics+and+effectiveness+as+treatment.&rft.au=Emrick%2C+C+D&rft.aulast=Emrick&rft.aufirst=C&rft.date=1989-01-01&rft.volume=7&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-11 N1 - Date created - 1989-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of alprazolam on respiratory drive, anxiety, and dyspnea in chronic airflow obstruction: a case study. AN - 78886489; 2922358 AB - Alprazolam, an anxiolytic benzodiazepine, has a pharmacologic profile similar to that of diazepam. An intermediate half-life of 10-12 hours and a comparatively brief duration of activity relative to other anxiolytic benzodiazepines justified evaluation of a 0.5-mg test dose in an anxious patient with chronic obstructive lung disease. Subjective indexes, breath-by-breath respiratory drive response to hypercapnia, and blood alprazolam concentrations were determined before and after dosing. Subjective testing included a visual analog dyspnea scale, the state anxiety inventory, and subjective feelings visual analog scales (represented by alertness, calmness, and level of contentment). After dosing, the patient was better able to tolerate the rebreathing study technique. Statistically significant improvements in dyspnea (t - 10.20; p 0.0005), anxiety (t - 45.85; p less than 0.0001), alertness (t - 13.04; p less than 0.0001), cententedness (t - 12.27; p less than 0.0001), and calmness (t - 8.05; p less than 0.0001) occurred after alprazolam administration. Drive to breathe, as determined by mouth occlusion pressure and minute ventilation, was not statistically different before and after dosing. No adverse effects were reported or observed. Further study is warranted. JF - Pharmacotherapy AU - Greene, J G AU - Pucino, F AU - Carlson, J D AU - Storsved, M AU - Strommen, G L AD - Veterans Administration Medical Center, Fargo, North Dakota 58102. Y1 - 1989 PY - 1989 DA - 1989 SP - 34 EP - 38 VL - 9 IS - 1 SN - 0277-0008, 0277-0008 KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Half-Life KW - Humans KW - Middle Aged KW - Male KW - Lung Diseases, Obstructive -- physiopathology KW - Anxiety KW - Alprazolam -- pharmacokinetics KW - Alprazolam -- pharmacology KW - Respiration -- drug effects KW - Lung Diseases, Obstructive -- metabolism KW - Dyspnea -- chemically induced KW - Lung Diseases, Obstructive -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78886489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Effects+of+alprazolam+on+respiratory+drive%2C+anxiety%2C+and+dyspnea+in+chronic+airflow+obstruction%3A+a+case+study.&rft.au=Greene%2C+J+G%3BPucino%2C+F%3BCarlson%2C+J+D%3BStorsved%2C+M%3BStrommen%2C+G+L&rft.aulast=Greene&rft.aufirst=J&rft.date=1989-01-01&rft.volume=9&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-20 N1 - Date created - 1989-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Excluding a psychoactive substance use disorder in forensic psychiatric evaluations. AN - 78880172; 2918289 AB - The forensic psychiatrist is sometimes asked to exclude that a person has a psychoactive substance use disorder, for example, in a security worker who has access to weapons, in a health care professional who may be alcohol/drug impaired, or in a parent, in a deprived child or custody hearing matter. After examining the data that are leading to the evaluation, these evaluations require corroborated background information to look for developmental and genetic antecedents that might be consistent with substance abuse and dependence; inquiry into the history of substance use; and an examination of areas, in which problems from substance use can occur, namely in family and other social relationships, at work, in legal settings, in physical health, and in personal and psychiatric reactions, for example, in suicidal behavior. Then a physical exam and laboratory evaluation are conducted to look for medical evidence of substance use and complications therefrom, and a mental status exam is performed and psychological testing is obtained as required, for example, a Minnesota Multiphasic Personality Inventory (MMPI) or neuropsychological testing. When such an evaluation is essentially negative, the examiner can say, within the limits of the evaluation, that a psychoactive substance use disorder does not exist. JF - Journal of forensic sciences AU - Lacoursiere, R B AD - Alcohol and Drug Treatment Program, Colmery-O/Neil Veterans Administration Medical Center, Topeka, KS. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 64 EP - 73 VL - 34 IS - 1 SN - 0022-1198, 0022-1198 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Opioid-Related Disorders -- diagnosis KW - Substance Withdrawal Syndrome -- diagnosis KW - Alcoholism -- diagnosis KW - Humans KW - MMPI KW - Adult KW - Neuropsychological Tests KW - Male KW - Female KW - Manuals as Topic KW - Substance-Related Disorders -- diagnosis KW - Forensic Psychiatry KW - Psychotropic Drugs -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78880172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+forensic+sciences&rft.atitle=Excluding+a+psychoactive+substance+use+disorder+in+forensic+psychiatric+evaluations.&rft.au=Lacoursiere%2C+R+B&rft.aulast=Lacoursiere&rft.aufirst=R&rft.date=1989-01-01&rft.volume=34&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Journal+of+forensic+sciences&rft.issn=00221198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-24 N1 - Date created - 1989-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cigarette smoke extract increases albumin flux across pulmonary endothelium in vitro. AN - 78878958; 2917949 AB - Cigarette smoking causes lung inflammation, and a characteristic of inflammation is an increase in vascular permeability. To determine if cigarette smoke could alter endothelial permeability, we studied flux of radiolabeled albumin across monolayers of porcine pulmonary artery endothelium grown in culture on microporous membranes. Extracts (in either dimethylsulfoxide or phosphate-buffered saline) of cigarette smoke in a range estimate of concentrations simulating cigarette smoke exposure to the lungs in vivo caused a dose-dependent increase in albumin flux that was dependent on extracellular divalent cations and associated with polymerization of cellular actin. The effect was reversible, independent of the surface of endothelial cells exposed (either luminal or abluminal), and due primarily to components of the vapor phase of smoke. The effects occurred without evidence of cell damage, but subtle morphological changes were produced by exposure to the smoke extracts. These findings suggest that cigarette smoke can alter permeability of the lung endothelium through effects on cytoskeletal elements. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Holden, W E AU - Maier, J M AU - Malinow, M R AD - Department of Medicine, Portland Veterans Administration Medical Center 97207. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 443 EP - 449 VL - 66 IS - 1 SN - 8750-7587, 8750-7587 KW - Actins KW - 0 KW - Serum Albumin KW - Smoke KW - Magnesium KW - I38ZP9992A KW - Calcium KW - SY7Q814VUP KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Swine KW - Animals KW - Dose-Response Relationship, Drug KW - Magnesium -- pharmacology KW - Actins -- metabolism KW - Capillary Permeability -- drug effects KW - Calcium -- pharmacology KW - Plants, Toxic KW - Serum Albumin -- metabolism KW - Endothelium, Vascular -- metabolism KW - Tobacco KW - Pulmonary Circulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78878958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Cigarette+smoke+extract+increases+albumin+flux+across+pulmonary+endothelium+in+vitro.&rft.au=Holden%2C+W+E%3BMaier%2C+J+M%3BMalinow%2C+M+R&rft.aulast=Holden&rft.aufirst=W&rft.date=1989-01-01&rft.volume=66&rft.issue=1&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-06 N1 - Date created - 1989-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation-induced soft tissue osteogenic sarcoma of the scalp. AN - 78878734; 2917809 JF - International journal of dermatology AU - Reyes, C V AD - Department of Dermatology, Veterans Administration Hospital, Hines, Illinois. PY - 1989 SP - 38 EP - 39 VL - 28 IS - 1 SN - 0011-9059, 0011-9059 KW - Index Medicus KW - Humans KW - Middle Aged KW - Radiography KW - Male KW - Radiotherapy -- adverse effects KW - Osteosarcoma -- etiology KW - Scalp KW - Neoplasms, Radiation-Induced -- pathology KW - Skin Neoplasms -- etiology KW - Osteosarcoma -- pathology KW - Osteosarcoma -- diagnostic imaging KW - Skin Neoplasms -- radiotherapy KW - Skin Neoplasms -- pathology KW - Skin Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78878734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+dermatology&rft.atitle=Radiation-induced+soft+tissue+osteogenic+sarcoma+of+the+scalp.&rft.au=Reyes%2C+C+V&rft.aulast=Reyes&rft.aufirst=C&rft.date=1989-01-01&rft.volume=28&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Ciba+Foundation+symposium&rft.issn=03005208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-29 N1 - Date created - 1989-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chlorine dioxide sterilization of implanted right atrial catheters in rabbits. AN - 78872393; 2918685 AB - The disinfection of right atrial catheters in situ using chlorine dioxide was investigated. Catheters were implanted into rabbits (Oryctolagus cuniculi) and colonized by inoculation of Staphylococcus aureus, Sa-80, into the lumen. All of the catheters were colonized and the difference in numbers of bacteria recovered from animals destined for the control and disinfection groups was not significant. Animals were assigned randomly to the control or disinfection group. Treatment consisted of filling the catheter lumen of the disinfection group with chlorine dioxide and of the control group with sterile physiological saline daily for 15 minutes. In addition, both groups received systemic antimicrobial therapy. Cultures of blood withdrawn from the catheters and by venipuncture were negative for five of the nine control group animals after treatment for 5 days. Four control group catheters failed, after from 3 to 21 treatments, without ever achieving negative cultures. All nine animals in the disinfection group had negative cultures after treatment for 5 days. Subsequently, one animal from each group reverted to positive cultures. All nine control group catheters failed during the study, compared to only three disinfection group catheters (p less than 0.01). At necropsy, culture of cardiac blood, thrombi and catheter tubing sections demonstrated colonization of six in the control group and only one in the disinfection group (p less than 0.05). Rabbits tolerated the chlorine dioxide disinfection well and no adverse signs were noted. JF - Laboratory animal science AU - Dennis, M B AU - Jones, D R AU - Tenover, F C AD - Seattle Veterans Administration Medical Center, WA 98108. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 51 EP - 55 VL - 39 IS - 1 SN - 0023-6764, 0023-6764 KW - Chlorine Compounds KW - 0 KW - Disinfectants KW - Oxides KW - Chlorine KW - 4R7X1O2820 KW - chlorine dioxide KW - 8061YMS4RM KW - Index Medicus KW - Animals KW - Random Allocation KW - Catheters, Indwelling -- veterinary KW - Rabbits KW - Female KW - Staphylococcal Infections -- therapy KW - Cardiac Catheterization -- veterinary KW - Sterilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78872393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+animal+science&rft.atitle=Chlorine+dioxide+sterilization+of+implanted+right+atrial+catheters+in+rabbits.&rft.au=Dennis%2C+M+B%3BJones%2C+D+R%3BTenover%2C+F+C&rft.aulast=Dennis&rft.aufirst=M&rft.date=1989-01-01&rft.volume=39&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Laboratory+animal+science&rft.issn=00236764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-04 N1 - Date created - 1989-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of alveolar epithelial injury by phospholipase A2. AN - 78869985; 2917929 AB - Severe damage to the alveolar type I epithelial cell is a characteristic morphological feature of lung injury due to numerous cases. It is postulated that excess phospholipase A2 (PLA2) activity might be responsible for these changes, as one of the naturally occurring products of this enzyme, lysophosphatidylcholine (lysoPC) has been shown to cause selective injury to the type I pneumonocyte when it is instilled into the lower air spaces of the lung. To further investigate this potential mechanism of type I epithelial cell toxicity, we have measured the epithelial permeability-surface area product (PS) for [14C]sucrose as well as whole-lung lysoPC content at several times after instilling PLA2 (Naja naja venom) into either the air spaces or the perfusate of an isolated hamster lung preparation. As a molar percentage of total phospholipids, the normal hamster lung contains approximately 1.5% lysoPC, and this value is not affected by fluid filling of the air spaces or perfusion of the excised lung for periods up to 90 min. When 0.15 U/ml PLA2 is instilled into the air spaces, lung lysoPC content increases to approximately 2.5% and there are barely detectable increases in [14C]sucrose PS. With air space PLA2 concentrations of 0.30 U/ml, lysoPC content increases to between 4 and 5%, [14C]sucrose PS increases by greater than a factor of 10, and flooding of the alveolar spaces occur. Ultrastructural studies of similarly treated lungs show widespread but selective damage to the type I epithelial cells. These same biochemical and functional changes are not seen when the same concentrations of PLA2 are added to the lung perfusate.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Niewoehner, D E AU - Rice, K AU - Duane, P AU - Sinha, A A AU - Gebhard, R AU - Wangensteen, D AD - Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 261 EP - 267 VL - 66 IS - 1 SN - 8750-7587, 8750-7587 KW - Lysophosphatidylcholines KW - 0 KW - Phosphatidylcholines KW - Phospholipids KW - Phospholipases KW - EC 3.1.- KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Animals KW - Perfusion KW - Phospholipids -- metabolism KW - Phosphatidylcholines -- metabolism KW - Lung -- metabolism KW - Hydrolysis KW - Lung -- physiology KW - Permeability KW - Bronchoalveolar Lavage Fluid -- metabolism KW - In Vitro Techniques KW - Lung -- drug effects KW - Mesocricetus KW - Microscopy, Electron KW - Epithelium -- metabolism KW - Lysophosphatidylcholines -- metabolism KW - Female KW - Cricetinae KW - Pulmonary Alveoli -- pathology KW - Phospholipases A -- pharmacology KW - Phospholipases -- pharmacology KW - Pulmonary Alveoli -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78869985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Induction+of+alveolar+epithelial+injury+by+phospholipase+A2.&rft.au=Niewoehner%2C+D+E%3BRice%2C+K%3BDuane%2C+P%3BSinha%2C+A+A%3BGebhard%2C+R%3BWangensteen%2C+D&rft.aulast=Niewoehner&rft.aufirst=D&rft.date=1989-01-01&rft.volume=66&rft.issue=1&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-06 N1 - Date created - 1989-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Longevity among ethnic groups in alcoholic liver disease. AN - 78861333; 2645888 AB - As part of a multicenter V.A. Cooperative Study, 437 male veterans with varying stages of alcoholic liver injury were followed over a 4.5 year period. Their ethnic distribution consisted of 256 Caucasians, 109 black Afro-Americans, 63 Puerto Rican Hispanics, and 9 Native American Indians. Survival analyses revealed significant differences between groups (P = 0.0002): 66% of Afro-Americans were still living at 42 months; Caucasians were intermediate with 40% survival; and only 28% of Hispanics were alive. The number of Native American Indians enrolled was too small to draw conclusions but none of those enrolled survived beyond 24 months. Survival regression analysis of 30 clinical, laboratory, histologic and nutritional parameters, revealed the following significant risk factors: clinical severity (P less than 0.0001), histologic severity (P less than 0.0001), race (P = 0.001), age (P = 0.002), BUN (P = 0.01) and ALT (P = 0.02). These analyses indicated that ethnicity, independent of other variables, is significantly associated with outcome from the disease. JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Mendenhall, C L AU - Gartside, P S AU - Roselle, G A AU - Grossman, C J AU - Weesner, R E AU - Chedid, A AD - Veterans Administration Medical Center, Cincinnati, OH. Y1 - 1989 PY - 1989 DA - 1989 SP - 11 EP - 19 VL - 24 IS - 1 SN - 0735-0414, 0735-0414 KW - Index Medicus KW - United States KW - Regression Analysis KW - Multicenter Studies as Topic KW - Puerto Rico -- ethnology KW - Humans KW - Aged KW - Indians, North American KW - Hispanic Americans KW - Patient Compliance KW - United States Department of Veterans Affairs KW - Risk Factors KW - European Continental Ancestry Group KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - African Continental Ancestry Group KW - Male KW - Liver Diseases, Alcoholic -- ethnology KW - Liver Diseases, Alcoholic -- pathology KW - Ethnic Groups KW - Liver Diseases, Alcoholic -- mortality KW - Alcoholism -- complications KW - Longevity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78861333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Longevity+among+ethnic+groups+in+alcoholic+liver+disease.&rft.au=Mendenhall%2C+C+L%3BGartside%2C+P+S%3BRoselle%2C+G+A%3BGrossman%2C+C+J%3BWeesner%2C+R+E%3BChedid%2C+A&rft.aulast=Mendenhall&rft.aufirst=C&rft.date=1989-01-01&rft.volume=24&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-11 N1 - Date created - 1989-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pleural mesothelial cells stimulated by asbestos release chemotactic activity for neutrophils in vitro. AN - 78849977; 2643374 AB - The development of the pleural inflammatory response to asbestos remains poorly defined. Importantly, the role of the pleural mesothelial cell in recruitment of neutrophils to the pleural space is not known. We hypothesized that rabbit pleural mesothelial cells stimulated by asbestos fibers release chemotactic factor(s) for neutrophils. Primary cultures of rabbit pleural mesothelial cells were established, and their purity verified by the presence of keratin and hyaluronic acid mucin. Mesothelial cells in serum-free media, in the presence of 30 micrograms/ml of crocidolite asbestos, released chemotaxins for neutrophils. This activity was not dependent on the type of asbestos fiber or fiber length. It was dose-dependent until 30 micrograms/ml of asbestos. The chemotactic fractions had the ability to increase both directed and random migration of neutrophils. The chemotactic activity was not present in sonicated fractions of unstimulated mesothelial cells, nor in supernates of asbestos fibers alone. Characterization of the chemotactic activity showed that it was heat stable (56 degrees C per 30 min) and sensitive to digestion with trypsin and papain. On Sephadex G-50 chromatography, it had a molecular weight between 6,000 and 9,000. Production of the chemotactic activity was inhibitable by cycloheximide. These results demonstrate that pleural mesothelial cells can actively synthesize a protein fraction with chemotactic activity for neutrophils. Production of this mesothelial cell-derived chemotactic activity for neutrophils may play an important role in the initiation of the inflammatory response of the pleura to asbestos. JF - The American review of respiratory disease AU - Antony, V B AU - Owen, C L AU - Hadley, K J AD - Department of Medicine, Veterans Administration Medical Center, Indianapolis, IN 46202. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 199 EP - 206 VL - 139 IS - 1 SN - 0003-0805, 0003-0805 KW - Chemotactic Factors KW - 0 KW - Interleukin-8 KW - Asbestos KW - 1332-21-4 KW - Cycloheximide KW - 98600C0908 KW - Trypsin KW - EC 3.4.21.4 KW - Abridged Index Medicus KW - Index Medicus KW - Hot Temperature KW - Animals KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Rabbits KW - Neutrophils -- physiology KW - Chemotaxis, Leukocyte KW - Trypsin -- pharmacology KW - Pleura -- drug effects KW - Pleura -- metabolism KW - Pleura -- cytology KW - Chemotactic Factors -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78849977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Pleural+mesothelial+cells+stimulated+by+asbestos+release+chemotactic+activity+for+neutrophils+in+vitro.&rft.au=Antony%2C+V+B%3BOwen%2C+C+L%3BHadley%2C+K+J&rft.aulast=Antony&rft.aufirst=V&rft.date=1989-01-01&rft.volume=139&rft.issue=1&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-15 N1 - Date created - 1989-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid synthesis and lipogenic enzymes in the rat. AN - 78845751; 2913289 AB - A single i.p. administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused within 1 wk of exposure a dose-dependent progressive inhibition of liver fatty acid synthetic rate with concomitant decreases in hepatic fatty acid synthetase and acetylcoenzyme A carboxylase activities. Similarly, hepatic cholesterol synthetic rate was markedly inhibited with increasing dosage of TCDD, although the corresponding decrease in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity was of lesser magnitude. Linear regression analyses of the reciprocals of the responses versus the dose revealed that the TCDD concentration which caused 50% inhibition of the activities of various lipogenic enzymes and of lipid synthetic rates ranged from 11 to 20 micrograms/kg (34-67 nM) with an average of 15 micrograms/kg (47 nM). Hepatic cholesterol synthesis seemed to be more sensitive to inhibition than fatty acid synthesis whether it was based on TCDD dosage or duration of exposure. The degree of inhibition of all the above parameters except fatty acid synthesis in liver and adipose tissues increased from 1 to 2 wk of exposure but was less pronounced after 4 wk exposure. Significantly, the adipose tissue was found to be more sensitive than the liver with respect to inhibition of fatty acid synthesis by increasing dosage of TCDD. Thus, the biochemical mechanism of loss of adipose mass caused by TCDD exposure may well be mediated by strong inhibition of lipid synthesis in the adipose tissue coupled with increased mobilization of depot fat. JF - The Journal of pharmacology and experimental therapeutics AU - Lakshman, M R AU - Chirtel, S J AU - Chambers, L L AU - Coutlakis, P J AD - Lipid Research Laboratory, Veterans Administration Medical Center, Washington, DC 20422. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 62 EP - 66 VL - 248 IS - 1 SN - 0022-3565, 0022-3565 KW - Dioxins KW - 0 KW - Lipids KW - Polychlorinated Dibenzodioxins KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Adipose Tissue -- metabolism KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Adipose Tissue -- drug effects KW - Liver -- metabolism KW - Male KW - Organ Size -- drug effects KW - Lipids -- biosynthesis KW - Polychlorinated Dibenzodioxins -- toxicity KW - Dioxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78845751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effects+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+on+lipid+synthesis+and+lipogenic+enzymes+in+the+rat.&rft.au=Lakshman%2C+M+R%3BChirtel%2C+S+J%3BChambers%2C+L+L%3BCoutlakis%2C+P+J&rft.aulast=Lakshman&rft.aufirst=M&rft.date=1989-01-01&rft.volume=12&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-03 N1 - Date created - 1989-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational exposure to organic solvents causing chronic tubulointerstitial nephritis. AN - 78840952; 2638566 AB - We describe a patient with a history of ulcerative colitis and long-standing occupational exposure to organic solvents. Over a follow-up period of almost four years he had progression of tubulointerstitial damage documented by two kidney biopsies. We propose that long-term exposure to organic solvents can lead to the development of chronic tubulointerstitial nephritis. We describe experimental evidence that supports our conclusion. JF - Archives of internal medicine AU - Narvarte, J AU - Saba, S R AU - Ramirez, G AD - Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, FL 33612. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 154 EP - 158 VL - 149 IS - 1 SN - 0003-9926, 0003-9926 KW - Hydrocarbons KW - 0 KW - Solvents KW - Abridged Index Medicus KW - Index Medicus KW - Aircraft KW - Humans KW - Adult KW - Chronic Disease KW - Hydrocarbons -- adverse effects KW - Male KW - Nephritis, Interstitial -- chemically induced KW - Solvents -- adverse effects KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78840952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Occupational+exposure+to+organic+solvents+causing+chronic+tubulointerstitial+nephritis.&rft.au=Narvarte%2C+J%3BSaba%2C+S+R%3BRamirez%2C+G&rft.aulast=Narvarte&rft.aufirst=J&rft.date=1989-01-01&rft.volume=149&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1990 Apr;150(4):919 [2327858] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. AN - 78840146; 2492170 AB - Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation. JF - The American review of respiratory disease AU - Light, R W AU - Muro, J R AU - Sato, R I AU - Stansbury, D W AU - Fischer, C E AU - Brown, S E AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 126 EP - 133 VL - 139 IS - 1 SN - 0003-0805, 0003-0805 KW - Carbon Dioxide KW - 142M471B3J KW - Morphine KW - 76I7G6D29C KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Exercise Test KW - Vital Capacity KW - Oxygen -- blood KW - Humans KW - Aged KW - Middle Aged KW - Forced Expiratory Volume KW - Carbon Dioxide -- blood KW - Male KW - Lung Diseases, Obstructive -- physiopathology KW - Morphine -- adverse effects KW - Respiration -- drug effects KW - Morphine -- administration & dosage KW - Lung Diseases, Obstructive -- blood KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78840146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Effects+of+oral+morphine+on+breathlessness+and+exercise+tolerance+in+patients+with+chronic+obstructive+pulmonary+disease.&rft.au=Light%2C+R+W%3BMuro%2C+J+R%3BSato%2C+R+I%3BStansbury%2C+D+W%3BFischer%2C+C+E%3BBrown%2C+S+E&rft.aulast=Light&rft.aufirst=R&rft.date=1989-01-01&rft.volume=139&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-15 N1 - Date created - 1989-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyanide-induced parkinsonism: clinical, MRI, and 6-fluorodopa PET studies. AN - 78836245; 2491915 AB - A 46-year-old man ingested 1,500 mg of potassium cyanide in a suicide attempt. He survived, but later developed a severe parkinsonian syndrome. MRI revealed multiple areas of low-signal intensity in the globus pallidus and posterior putamen. A 6-fluorodopa PET study revealed bilateral decreased uptake in the basal ganglia. This evidence of functional impairment of dopaminergic nigrostriatal neurons is related either to direct toxicity of cyanide or to the effects of cerebral hypoxia secondary to cyanide intoxication. JF - Neurology AU - Rosenberg, N L AU - Myers, J A AU - Martin, W R AD - Research Service, Veterans Administration Medical Center, Denver, CO 80220. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 142 EP - 144 VL - 39 IS - 1 SN - 0028-3878, 0028-3878 KW - Cyanides KW - 0 KW - fluorodopa F 18 KW - 2C598205QX KW - Dihydroxyphenylalanine KW - 63-84-3 KW - Potassium Cyanide KW - MQD255M2ZO KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Suicide, Attempted KW - Humans KW - Tomography, Emission-Computed KW - Middle Aged KW - Male KW - Dihydroxyphenylalanine -- analogs & derivatives KW - Parkinson Disease, Secondary -- chemically induced KW - Cyanides -- poisoning KW - Potassium Cyanide -- poisoning KW - Parkinson Disease, Secondary -- diagnostic imaging KW - Parkinson Disease, Secondary -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78836245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Cyanide-induced+parkinsonism%3A+clinical%2C+MRI%2C+and+6-fluorodopa+PET+studies.&rft.au=Rosenberg%2C+N+L%3BMyers%2C+J+A%3BMartin%2C+W+R&rft.aulast=Rosenberg&rft.aufirst=N&rft.date=1989-01-01&rft.volume=39&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-09 N1 - Date created - 1989-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of menses, estrogens and hemolysis on a serum-lectin-like factor in cystic fibrosis. AN - 78835746; 2909327 AB - Twelve CF heterozygous and two CF homozygous women who were tested serially for the CF-lectin activities during one to two months of their menstrual cycles, were found consistently to have negative tests during menses. The specific hormonal alteration during menses that affects the assay is unknown. However, estrogenic medication administered without progesterone to postmenopausal heterozygous women also caused false-negative tests, suggesting that a balance between progesterone and estrogen is critical for the CF-lectin activity; mere depletion of these hormones alone does not interfere. The addition of estrogen in vitro also inhibited the CF-lectin activity at a physiologic concentration of 10(-6) M, and addition of an equivalent concentration of progesterone blocked this inhibitory effect. Future studies of the CF-lectin or its assay as a potential CF-carrier test must be limited to those women not menstruating at the time of blood drawing and not receiving estrogens. Hemolysis or contamination of the serum with RBC should invalidate that sample for testing, although the effect of RBC contamination can be circumvented with the addition of mannose. A more objective, simplified means of performing the CF-lectin assay is reported. A preliminary blind study taking these issues into consideration was 100 percent correct in detecting 16 CF patients and 17 obligate heterozygotes, and revealed 4 percent of 64 control subjects to have positive tests. The presence of this lectin-like factor may reflect the underlying biochemical defect responsible for this disease. JF - Chest AU - Lieberman, J AU - Tachiki, K H AD - Department of Medicine, Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 111 EP - 116 VL - 95 IS - 1 SN - 0012-3692, 0012-3692 KW - Estrogens KW - 0 KW - Lectins KW - Progesterone KW - 4G7DS2Q64Y KW - Diethylstilbestrol KW - 731DCA35BT KW - Mannose KW - PHA4727WTP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Progesterone -- pharmacology KW - Menopause -- drug effects KW - Humans KW - Heterozygote KW - Diethylstilbestrol -- pharmacology KW - Mice KW - Pregnancy Complications -- blood KW - Female KW - Agglutination Tests KW - Pregnancy KW - Mannose -- pharmacology KW - Cystic Fibrosis -- blood KW - Estrogens -- pharmacology KW - Cystic Fibrosis -- genetics KW - Hemolysis KW - Menstruation KW - Lectins -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78835746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Effect+of+menses%2C+estrogens+and+hemolysis+on+a+serum-lectin-like+factor+in+cystic+fibrosis.&rft.au=Lieberman%2C+J%3BTachiki%2C+K+H&rft.aulast=Lieberman&rft.aufirst=J&rft.date=1989-01-01&rft.volume=95&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-01 N1 - Date created - 1989-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nail discoloration due to mahogany. AN - 78833758; 2521598 AB - A patient is described in whom orange-brown discoloration occurred following occupational exposure to mahogany wood. Mahogany-induced dermatitis is reviewed. JF - Cutis AU - Harris, A O AU - Rosen, T AD - Veterans Administration Medical Center, Dermatology Service, Houston, Texas 77030. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 55 EP - 56 VL - 43 IS - 1 SN - 0011-4162, 0011-4162 KW - Index Medicus KW - Dermatitis, Occupational -- etiology KW - Humans KW - Adult KW - Dermatitis, Contact -- etiology KW - Male KW - Occupational Diseases -- etiology KW - Wood KW - Nails KW - Pigmentation Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78833758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Nail+discoloration+due+to+mahogany.&rft.au=Harris%2C+A+O%3BRosen%2C+T&rft.aulast=Harris&rft.aufirst=A&rft.date=1989-01-01&rft.volume=43&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of steroids on serotonin-N-acetyltransferase activity of pineals in organ culture. AN - 78833156; 2535714 AB - Treatment of neonatal, but not adult, rats with glucocorticoids decreases the rise in pineal serotonin N-acetyltransferase activity upon stimulation with beta agonists. Pineals in organ culture and exposed to steroids also show a dose-dependent decrement in response to beta agonists which increases with steroid exposure time. Pineals from neonatal and adult animals are equally sensitive. The effects of steroids on pineals in organ culture appear to be reversible, and the order of potency of different steroids differs from that observed when steroids are administered in vivo. Both in vitro and in vivo steroids appear to act at a site after cyclic AMP generation. Hydroxyindole-O-methyltransferase activity in the adult pineal does not appear affected by steroid exposure. JF - Journal of neurochemistry AU - Yuwiler, A AD - Neurobiochemistry Research Laboratory, Veterans Administration Medical Center, Brentwood, California. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 46 EP - 53 VL - 52 IS - 1 SN - 0022-3042, 0022-3042 KW - Indoles KW - 0 KW - Steroids KW - Colforsin KW - 1F7A44V6OU KW - Bucladesine KW - 63X7MBT2LQ KW - Tryptophan KW - 8DUH1N11BX KW - Cholera Toxin KW - 9012-63-9 KW - Acetyltransferases KW - EC 2.3.1.- KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - Melatonin KW - JL5DK93RCL KW - Isoproterenol KW - L628TT009W KW - Corticosterone KW - W980KJ009P KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cholera Toxin -- pharmacology KW - Tryptophan -- metabolism KW - Bucladesine -- pharmacology KW - Isoproterenol -- pharmacology KW - Rats KW - Hydrocortisone -- pharmacology KW - Rats, Inbred F344 KW - Colforsin -- pharmacology KW - Indoles -- metabolism KW - Corticosterone -- pharmacology KW - Organ Culture Techniques KW - Male KW - Melatonin -- metabolism KW - Acetyltransferases -- metabolism KW - Steroids -- pharmacology KW - Pineal Gland -- enzymology KW - Pineal Gland -- drug effects KW - Arylamine N-Acetyltransferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78833156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Effects+of+steroids+on+serotonin-N-acetyltransferase+activity+of+pineals+in+organ+culture.&rft.au=Yuwiler%2C+A&rft.aulast=Yuwiler&rft.aufirst=A&rft.date=1989-01-01&rft.volume=52&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-25 N1 - Date created - 1989-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence for inhibition of opossum LES through intrinsic gastric nerves. AN - 78831793; 2563200 AB - We have studied the mechanical responses of the isolated opossum gastroesophageal junction to a variety of stimuli. Lower esophageal sphincter (LES) relaxations were readily produced by gastric stretch and by electrical stimulation of the intramural gastric nerves. Gastric stimulation also led in 60% of stimuli to a contraction of circular muscle (the off response) in the distal esophagus, but in less than 15% of stimuli to a contraction of longitudinal esophageal muscle (the duration response). Mechanical or electrical stimulation of the esophagus led to a mechanical response of the stomach (relaxation, contraction, or both) in 76% of stimuli. The LES relaxation produced by esophageal stimulation was not as long as that produced by gastric stimulation. Direct electrical stimulation of the esophageal or gastric muscle produced a ring contraction that spread readily across the gastroesophageal junction but did not produce a relaxation of the LES or a contraction of the longitudinal esophageal muscle. Thus intramural nervous pathways can coordinate the mechanical activity of the esophagus, LES, and stomach. LES relaxations may occur as part of intrinsic reflexes that mediate gastric accommodation to volume. JF - The American journal of physiology AU - Schulze-Delrieu, K AU - Percy, W H AU - Ren, J AU - Shirazi, S S AU - Von Derau, K AD - Gastroenterological Research Laboratories, Veterans Administration Medical Center, Iowa City, Iowa 52240. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - G198 EP - G205 VL - 256 IS - 1 Pt 1 SN - 0002-9513, 0002-9513 KW - Hexamethonium Compounds KW - 0 KW - Hexamethonium KW - 3C9PSP36Z2 KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Animals KW - Muscle Contraction -- drug effects KW - Muscle Relaxation -- drug effects KW - Physical Stimulation KW - Tetrodotoxin -- pharmacology KW - Electric Stimulation KW - Hexamethonium Compounds -- pharmacology KW - Esophagus -- physiology KW - Esophagogastric Junction -- physiology KW - Stomach -- innervation KW - Stomach -- physiology KW - Esophagogastric Junction -- innervation KW - Opossums -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78831793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Evidence+for+inhibition+of+opossum+LES+through+intrinsic+gastric+nerves.&rft.au=Schulze-Delrieu%2C+K%3BPercy%2C+W+H%3BRen%2C+J%3BShirazi%2C+S+S%3BVon+Derau%2C+K&rft.aulast=Schulze-Delrieu&rft.aufirst=K&rft.date=1989-01-01&rft.volume=256&rft.issue=1+Pt+1&rft.spage=G198&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-21 N1 - Date created - 1989-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro evidence for dose-dependent cytotoxicity as the predominant effect of low dose Ara-C on human leukemic and normal marrow cells. AN - 78828771; 2910516 AB - To determine whether cytosine arabinoside (Ara-C) has a differentiating effect in vitro, marrow cells from nine patients with acute non-lymphocytic leukemia or myelodysplastic syndrome and eight non-leukemic controls were exposed to drug concentrations comparable to those achieved in vivo with low-dose Ara-C therapy. In soft agar cultures, the predominant effect of Ara-C at concentrations between 10(-8) M and 10(-6) M was cytotoxicity with a dose-dependent decrement in Colony Forming Unit of the granulocyte and monocyte lineage (CFUg/m) at 14 days. Growth in liquid cultures containing Giant Cell Tumor(GCT)-conditioned media without Ara-C resulted in a significant increment in the recovery of mature cells at day 10 from the non-leukemic cultures (P = 0.03), while only a minor increase was found in the leukemic cultures (P = 0.09). All liquid cultures exposed to greater than or equal to 10(-9) M Ara-C showed a marked reduction in the immature proliferating cell pool, with a concomitant increase in the percentage of mature non-dividing cells at 10 days. However, the absolute number of differentiated cells recovered remained constant or decreased in all non-leukemic and eight of nine leukemic cultures, compared with cultures without Ara-C. Enhanced recovery of differentiated cells was also never observed in any culture exposed to the relatively non-toxic 10(-9) M Ara-C. These in vitro findings support clinical observations suggesting that cytotoxicity rather than differentiation is the major mechanism involved in the therapeutic effect of low-dose Ara-C in acute leukemia and myelodysplasia. JF - Cancer chemotherapy and pharmacology AU - Chan, C S AU - Schechter, G P AD - Hematology Section, Veterans Administration Medical Center, Washington, DC, 20422. Y1 - 1989 PY - 1989 DA - 1989 SP - 87 EP - 94 VL - 23 IS - 2 SN - 0344-5704, 0344-5704 KW - Cytarabine KW - 04079A1RDZ KW - Index Medicus KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Cell Differentiation -- drug effects KW - Hematopoietic Stem Cells -- drug effects KW - Leukemia -- pathology KW - Cytarabine -- pharmacology KW - Cytarabine -- administration & dosage KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78828771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=In+vitro+evidence+for+dose-dependent+cytotoxicity+as+the+predominant+effect+of+low+dose+Ara-C+on+human+leukemic+and+normal+marrow+cells.&rft.au=Chan%2C+C+S%3BSchechter%2C+G+P&rft.aulast=Chan&rft.aufirst=C&rft.date=1989-01-01&rft.volume=23&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-13 N1 - Date created - 1989-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lithium carbonate intoxication. A case report and review of the literature. AN - 78828544; 2492186 AB - Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, this medication has a low therapeutic index and, therefore, many attendant side effects. Acute lithium carbonate intoxication affects predominantly the central nervous system and the renal system and is potentially lethal. We studied a case of acute lithium carbonate intoxication characterized by a prolonged comatose state, severe nephrogenic diabetes insipidus, and glucose intolerance. Of interest, the patient's symptoms and signs of toxic reaction developed after normalization of the plasma lithium ion levels. We reviewed the multisystemic toxic effects of lithium carbonate as well as its teratogenic potential and guidelines for its use during pregnancy. The management of acute lithium carbonate intoxication should include hydration with normal saline, intensive care monitoring, and dialysis if indicated. JF - Archives of internal medicine AU - Simard, M AU - Gumbiner, B AU - Lee, A AU - Lewis, H AU - Norman, D AD - Department of Medicine, Veterans Administration Medical Center West Los Angeles Wadsworth Division, CA 90073. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 36 EP - 46 VL - 149 IS - 1 SN - 0003-9926, 0003-9926 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Lithium KW - 9FN79X2M3F KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Lithium -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78828544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Lithium+carbonate+intoxication.+A+case+report+and+review+of+the+literature.&rft.au=Simard%2C+M%3BGumbiner%2C+B%3BLee%2C+A%3BLewis%2C+H%3BNorman%2C+D&rft.aulast=Simard&rft.aufirst=M&rft.date=1989-01-01&rft.volume=149&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of verapamil on tardive dyskinesia and psychosis in schizophrenic patients. AN - 78825579; 2562952 AB - Nine hospitalized schizophrenic patients with tardive dyskinesia were treated with the calcium-channel antagonist verapamil under single-blind conditions. The tardive dyskinesia and activation scores decreased, and the anxiety/depression scores increased. The changes were small but statistically significant. JF - The Journal of clinical psychiatry AU - Reiter, S AU - Adler, L AU - Angrist, B AU - Peselow, E AU - Rotrosen, J AD - Psychiatry Service, New York Veterans Administration Medical Center, NY 10010. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 26 EP - 27 VL - 50 IS - 1 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Verapamil KW - CJ0O37KU29 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Depressive Disorder -- psychology KW - Anxiety Disorders -- psychology KW - Humans KW - Adult KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Male KW - Dyskinesia, Drug-Induced -- drug therapy KW - Dyskinesia, Drug-Induced -- psychology KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Verapamil -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78825579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Effects+of+verapamil+on+tardive+dyskinesia+and+psychosis+in+schizophrenic+patients.&rft.au=Reiter%2C+S%3BAdler%2C+L%3BAngrist%2C+B%3BPeselow%2C+E%3BRotrosen%2C+J&rft.aulast=Reiter&rft.aufirst=S&rft.date=1989-01-01&rft.volume=50&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-14 N1 - Date created - 1989-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antidepressants and the cardiac patient. Selecting an appropriate medication. AN - 78824681; 2911542 JF - Postgraduate medicine AU - Pary, R AU - Tobias, C R AU - Lippmann, S AD - Department of Psychiatry and Behavioral Sciences, Veterans Administration Medical Center, Louisville, KY 40202. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 267 EP - 72, 274-6 VL - 85 IS - 1 SN - 0032-5481, 0032-5481 KW - Antidepressive Agents KW - 0 KW - Antidepressive Agents, Tricyclic KW - Monoamine Oxidase Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Monoamine Oxidase Inhibitors -- adverse effects KW - Heart Rate -- drug effects KW - Drug Interactions KW - Humans KW - Electrocardiography KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Depressive Disorder -- drug therapy KW - Heart Conduction System -- physiopathology KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Blood Pressure -- drug effects KW - Monoamine Oxidase Inhibitors -- therapeutic use KW - Depressive Disorder -- complications KW - Antidepressive Agents -- therapeutic use KW - Heart Diseases -- complications KW - Heart Diseases -- physiopathology KW - Antidepressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78824681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Antidepressants+and+the+cardiac+patient.+Selecting+an+appropriate+medication.&rft.au=Pary%2C+R%3BTobias%2C+C+R%3BLippmann%2C+S&rft.aulast=Pary&rft.aufirst=R&rft.date=1989-01-01&rft.volume=85&rft.issue=1&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-22 N1 - Date created - 1989-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recombinant human tumor necrosis factor alone and with chemotherapeutic agents. Effect on nude mouse-supported human bladder cancer heterografts. AN - 78822998; 2910237 AB - Although studies done in tissue culture (in vitro) have shown synergism between recombinant human tumor necrosis factor (rhTNF) and chemotherapeutic agents, whether such synergism exists in a complex in vivo environment with acceptable toxic side effects has not been determined, to our knowledge. The effect of rhTNF alone and in combination with cisplatin, etoposide, doxorubicin, or dactinomycin on the growth of heterotransplants of human bladder transitional cell carcinoma was studied using a modified subrenal capsule assay in athymic nude mice. Only etoposide potentiated rhTNF cytotoxicity; no increase in host toxicity was noted. Variably enhanced toxic side effects were seen with other combinations. It is concluded that rhTNF combined with etoposide may have potential clinically exploitable therapeutic "synergism" in the treatment of advanced bladder cancer. JF - Archives of surgery (Chicago, Ill. : 1960) AU - Das, A K AU - Walther, P J AU - Buckley, N J AU - Poulton, S H AD - Department of Surgery, Durham Veterans Administration Medical Center, NC. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 107 EP - 110 VL - 124 IS - 1 SN - 0004-0010, 0004-0010 KW - Antineoplastic Agents KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Dactinomycin KW - 1CC1JFE158 KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Carcinoma, Transitional Cell -- pathology KW - Dactinomycin -- therapeutic use KW - Etoposide -- therapeutic use KW - Mice, Nude KW - Mice KW - Doxorubicin -- administration & dosage KW - Cisplatin -- administration & dosage KW - Neoplasm Transplantation KW - Drug Therapy, Combination KW - Cisplatin -- therapeutic use KW - Etoposide -- administration & dosage KW - Subrenal Capsule Assay KW - Carcinoma, Transitional Cell -- mortality KW - Doxorubicin -- therapeutic use KW - Drug Synergism KW - Carcinoma, Transitional Cell -- drug therapy KW - Cell Line KW - Dactinomycin -- administration & dosage KW - Urinary Bladder Neoplasms -- pathology KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Urinary Bladder Neoplasms -- drug therapy KW - Urinary Bladder Neoplasms -- mortality KW - Tumor Necrosis Factor-alpha -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78822998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Recombinant+human+tumor+necrosis+factor+alone+and+with+chemotherapeutic+agents.+Effect+on+nude+mouse-supported+human+bladder+cancer+heterografts.&rft.au=Das%2C+A+K%3BWalther%2C+P+J%3BBuckley%2C+N+J%3BPoulton%2C+S+H&rft.aulast=Das&rft.aufirst=A&rft.date=1989-01-01&rft.volume=124&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00040010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-01 N1 - Date created - 1989-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cocaine-associated rhabdomyolysis and acute renal failure. AN - 78820832; 2911765 AB - We have described four male patients, aged 21 to 39 years, who had rhabdomyolysis and acute renal failure during parenteral cocaine use. This complication has only recently been attributed to cocaine. Their illnesses behaved clinically like nonoliguric acute tubular necrosis, though renal biopsies were not done. No permanent nerve, muscle, or kidney damage resulted. JF - Southern medical journal AU - Anand, V AU - Siami, G AU - Stone, W J AD - Medical Service, Veterans Administration Medical Center, Nashville, TN 37212. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 67 EP - 69 VL - 82 IS - 1 SN - 0038-4348, 0038-4348 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Injections, Intravenous KW - Humans KW - Adult KW - Male KW - Acute Kidney Injury -- chemically induced KW - Rhabdomyolysis -- chemically induced KW - Substance-Related Disorders -- complications KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78820832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Cocaine-associated+rhabdomyolysis+and+acute+renal+failure.&rft.au=Anand%2C+V%3BSiami%2C+G%3BStone%2C+W+J&rft.aulast=Anand&rft.aufirst=V&rft.date=1989-01-01&rft.volume=82&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: South Med J. 1989 Sep;82(9):1196-7 [2772692] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol and Masculinity AN - 61436699; 199001377 AB - Alcohol use & abuse have always been more prevalent among males than among females, due to the sex role prescription for men to affirm their masculinity by drinking. An overview of previous research is provided to explore the intricate interrelationship between masculinity & both social & alcoholic drinking, & it is found that social drinking is a primary cultural symbol of manliness that is strengthened by media portrayals. Less evidence exists to connect masculinity issues with alcoholic dependence, but three psychodynamic theories of alcoholism -- repressed homosexuality, dependency, & power theories -- hypothesize that men who drink addictively have the most fragile masculine identities. The 1980s have witnessed a widespread recognition of the dangers of equating drinking & manliness, & societal changes suggest that drinking may be gradually losing its masculine aura. 111 References. Modified HA JF - Journal of Substance Abuse Treatment AU - Lemle, Russell AU - Mishkind, Marc E AD - Alcohol Clinic Veterans Administration Medical Center, 4150 Clement San Francisco CA 94121 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 213 EP - 222 VL - 6 IS - 4 SN - 0740-5472, 0740-5472 KW - alcohol use-masculinity relationship, sociocultural/media/personal psychological influences KW - secondary research KW - Masculinity KW - Alcohol Abuse KW - Sociocultural Factors KW - Sex Differences KW - Alcohol Use KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61436699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Alcohol+and+Masculinity&rft.au=Lemle%2C+Russell%3BMishkind%2C+Marc+E&rft.aulast=Lemle&rft.aufirst=Russell&rft.date=1989-01-01&rft.volume=6&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Alcohol Abuse; Alcohol Use; Masculinity; Sociocultural Factors; Sex Differences ER - TY - JOUR T1 - Distance from Mother and Father among Alcoholics AN - 61017639; 89U8705 AB - The relationship of parental closeness to current drinking patterns, behavior, & psychopathology in alcoholics is examined using data from interviews, scales, & psychological tests completed by a sample of 70 male inpatients on an alcohol treatment unit & 30 inpatients on a general surgical ward of the same Veteran's Administration Medical Center. Results indicate that alcoholics perceive a greater distance between themselves & their parents than do medical patients. Though comparison analyses of mother & father distance scores yield only a few differences, correlational analyses indicate that distance from parents is related to parental alcohol abuse & absence, though not to current behavior (except anger). 4 Tables, 31 References. Modified HA JF - Advances in Alcohol and Substance Abuse AU - Brown, Reba Hutto AU - Hyer, Lee AU - Harrison, William AD - Veterans Administration Medical Center, Augusta GA 30901 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 75 EP - 91 VL - 8 IS - 1 KW - current drinking patterns/behavior/psychopathology, alcoholics KW - parental closeness KW - interview/scale/test data KW - male inpatients KW - Social Distance KW - Perceptions KW - Alcoholism KW - Family Roles KW - Parent Child Relations KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61017639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Alcohol+and+Substance+Abuse&rft.atitle=Distance+from+Mother+and+Father+among+Alcoholics&rft.au=Brown%2C+Reba+Hutto%3BHyer%2C+Lee%3BHarrison%2C+William&rft.aulast=Brown&rft.aufirst=Reba&rft.date=1989-01-01&rft.volume=8&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Advances+in+Alcohol+and+Substance+Abuse&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AASADR N1 - SubjectsTermNotLitGenreText - Alcoholism; Parent Child Relations; Social Distance; Perceptions; Family Roles ER - TY - JOUR T1 - Language in Normal Aging: Linguistic and Neuropsychological Factors AN - 58223973; 9007482 AB - Addressed is the question of what neuropsychological factors are associated with the language changes that occur in normal aging. A battery of neuropsychological & naming tests was administered to a group of males & females (N = 152, aged 30-79). The neuropsychological battery included tests of attention, visuo-perceptual skills, short- & long-term memory, semantic memory, & metalinguistic skills. The naming tests included the Boston Naming Test, the Action Naming Test, & the Category Naming Test. Multiple regression analyses revealed that neuropsychological factors did contribute to naming abilities; however, the specific factors differed for each age group. Results suggested that as people age, the involvement of neuropsychological functions in naming decreases. These findings suggest that the naming deficits of normal aging result from linguistic changes & are not significantly affected by other neuropsychological factors. 7 Tables, 22 References. AA JF - Journal of Neurolinguistics AU - Au, Rhoda AU - Albert, Martin L AU - Obler, Loraine K AD - Dept Neurology Boston Veterans Administration Medical Center, MA 02130 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 347 EP - 364 VL - 4 IS - 3-4 SN - 0911-6044, 0911-6044 KW - language changes, normal aging processes, neuropsychological factors KW - test battery KW - males/females aged 30-79 KW - Neurolinguistics (ne3a) KW - Cognitive Processes (co1b) KW - Long-Term Memory (lo3) KW - Short-Term Memory (sh2) KW - Age Differences in Language (ag1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58223973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=Language+in+Normal+Aging%3A+Linguistic+and+Neuropsychological+Factors&rft.au=Au%2C+Rhoda%3BAlbert%2C+Martin+L%3BObler%2C+Loraine+K&rft.aulast=Au&rft.aufirst=Rhoda&rft.date=1989-01-01&rft.volume=4&rft.issue=3-4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Age Differences in Language (ag1); Short-Term Memory (sh2); Long-Term Memory (lo3); Cognitive Processes (co1b) ER - TY - JOUR T1 - Family Therapy with Spinal Cord Injured Substance Abusers AN - 1761726054; 199001816 AB - Overdependency & overachievement issues & the contributions of family therapy are examined based on work with 25 patients over the past 5 years in the special treatment unit for spinal-cord-injured substance abusers at the Long Beach (Calif) Veterans Administration Medical Center Spinal Cord Injury Service. Incorporation of family therapy into the special treatment ward is now considered an important part of an integrated program, despite initial resistance by the staff. Potential use of family therapy in other chronic illnesses or disabilities is proposed. 4 References. M. Malas JF - Social Work in Health Care AU - Perez, Marta AU - Pilsecker, Carleton AD - Veterans Administration Medical Center, 5901 East 7th St Long Beach CA 90822 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 15 EP - 25 VL - 14 IS - 2 SN - 0098-1389, 0098-1389 KW - spinal-cord-injured substance abusers, overdependency/overachievement issues, family therapy program, Long Beach (California) Veterans' Administration Center KW - California KW - Veterans KW - Drug Addiction KW - Substance Abuse KW - Injuries KW - Family Therapy KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761726054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Family+Therapy+with+Spinal+Cord+Injured+Substance+Abusers&rft.au=Perez%2C+Marta%3BPilsecker%2C+Carleton&rft.aulast=Perez&rft.aufirst=Marta&rft.date=1989-01-01&rft.volume=14&rft.issue=2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Substance Abuse; Family Therapy; Injuries; Veterans; California; Drug Addiction ER - TY - JOUR T1 - Theory and Method in Treatment Evaluation AN - 1761725762; 199000760 AB - Outlined is a conceptual model of evaluation research that has both guided & flowed from research on the process & outcome of treatment for alcohol abuse & for depression. The model encompasses three basic processes: treatment selection, treatment, & the onset & course of the disorder or problem being treated. Discussed are how theories can guide both experimental & naturalistic evaluations, as well as aid in the estimation of treatment effects with either type of design. The role of theory & method in exploring patient-treatment matching is also considered, along with implications of theory-guidance for the utility of evaluations -- particularly for evaluation researchers. 1 Table, 47 References. HA JF - Evaluation and Program Planning AU - Finney, John W AU - Moos, Rudolf H AD - Social Ecology Laboratory Veterans' Administration Medical Center 116A4 , 3801 Miranda Ave Palo Alto CA 94304 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 307 EP - 316 VL - 12 IS - 4 SN - 0149-7189, 0149-7189 KW - treatment program evaluation, conceptual model KW - Substance Abuse KW - Treatment Programs KW - Evaluation Research KW - Theory Practice Relationship KW - Program Evaluation KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761725762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+and+Program+Planning&rft.atitle=Theory+and+Method+in+Treatment+Evaluation&rft.au=Finney%2C+John+W%3BMoos%2C+Rudolf+H&rft.aulast=Finney&rft.aufirst=John&rft.date=1989-01-01&rft.volume=12&rft.issue=4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Evaluation+and+Program+Planning&rft.issn=01497189&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Programs; Program Evaluation; Theory Practice Relationship; Evaluation Research; Substance Abuse ER - TY - JOUR T1 - Universal Health Insurance in Massachusetts: Negotiating Policy Compromise AN - 1463025387; 198901526 AB - The Massachusetts Health Security Act is the first universal-access financing legislation in the country, & sets a precedent for providing health coverage for the 600,000 uninsured in the state. The bill is the product of prolonged negotiation among hospitals, business interests, insurers, & advocates of universal access, who debated the extent of benefits, the cost of care, & the system that will monitor & regulate its provision. While the bill represents an important step in addressing the service requirements of the uninsured, it falls short of meeting the needs of the underinsured, eg, elderly persons unable to afford Medex insurance to supplement Medicare coverage. 3 Figures, 37 References. Modified HA JF - Journal of Aging & Social Policy AU - Marcus, Leonard J AD - Veterans Administration, West Roxbury MA 02132 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 33 EP - 59 VL - 1 IS - 1-2 SN - 0895-9420, 0895-9420 KW - universal health care access, financing legislation, Massachusetts KW - Financial Support KW - Health Care KW - Nationalization KW - Health Insurance KW - Massachusetts KW - Health Policy KW - article KW - 6125: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463025387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+%26+Social+Policy&rft.atitle=Universal+Health+Insurance+in+Massachusetts%3A+Negotiating+Policy+Compromise&rft.au=Marcus%2C+Leonard+J&rft.aulast=Marcus&rft.aufirst=Leonard&rft.date=1989-01-01&rft.volume=1&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+%26+Social+Policy&rft.issn=08959420&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Massachusetts; Health Policy; Health Insurance; Nationalization; Health Care; Financial Support ER - TY - JOUR T1 - Is Burnout an Institutional Syndrome? AN - 1463016554; 90V2111 AB - Some of the shortcomings of the appraisal & reward system for employees of federal institutions are identified, along with some potential explanations for their existence. A process-focused model is offered that views initial disillusionment leading to eventual burnout along a continuum that includes apathy, frustration, & alienation. This is paralleled by an individual's inner experience of his/herself as related to work & to personal life, which in turn influences how one is able to cope with a seemingly uncaring & unresponsive environment in a way that avoids burnout. 4 References. K. Hyatt JF - Loss, Grief & Care AU - Weiner, William AD - Dept Social Services Bronx Veterans Administration Hospital, 130 West Kingsbridge Rd 1 NY 10468 Y1 - 1989///0, PY - 1989 DA - 0, 1989 SP - 95 EP - 100 VL - 3 IS - 1-2 SN - 8756-4610, 8756-4610 KW - employee burnout, federal institutions, process-focused model KW - Workers KW - Public Officials KW - Occupational Stress KW - Rewards KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463016554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Loss%2C+Grief+%26+Care&rft.atitle=Is+Burnout+an+Institutional+Syndrome%3F&rft.au=Weiner%2C+William&rft.aulast=Weiner&rft.aufirst=William&rft.date=1989-01-01&rft.volume=3&rft.issue=1-2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Loss%2C+Grief+%26+Care&rft.issn=87564610&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - LGCAE9 N1 - SubjectsTermNotLitGenreText - Occupational Stress; Rewards; Public Officials; Workers ER - TY - JOUR T1 - Do transcriptional enhancers also augment DNA replication? AN - 78595065; 2849759 AB - Enhancers are DNA elements that augment transcription in cis, independent of distance and orientation. Evidence such as hormone dependent neoplastic cell growth and the stimulation of viral replication by sequences present in enhancers suggests that enhancers may also directly affect DNA replication. We tested this hypothesis in recombinant plasmids by asking whether sequences that stimulated DNA replication shared the properties of transcriptional enhancers. The homologous simian virus 40 (SV40) core enhancer was ligated either adjacent to or 2.6 kb distant from the SV40 minimal origin of replication (ori) in both orientations. Plasmids were transfected into T antigen producing COS cells, and episomal DNA was harvested for quantitation of replication. Replication could be assessed either as accumulation of fmol of MboI sensitive progeny DNA, or as a transition in % DNA in replicated (MboI sensitive) versus unreplicated (DpnI sensitive) form. The two measures were related exponentially (r = 0.86). The SV40 enhancer augmented replication 1.5-10 fold. The effect was time dependent, distance dependent (only the adjacent enhancer locus stimulated replication), partially orientation dependent, and enhancer copy number independent. Phorbol ester did not affect replication. The heterologous glucocorticoid enhancer had no effect on replication. We conclude that the SV40 enhancer's cis-effect on replication seems to be dependent on the close proximity to the replication origin of specific homologous sequences within the enhancer, rather than a typical enhancer-like effect. JF - Nucleic acids research AU - O'Connor, D T AU - Subramani, S AD - Veterans Administration Medical Center, San Diego, CA. Y1 - 1988/12/09/ PY - 1988 DA - 1988 Dec 09 SP - 11207 EP - 11222 VL - 16 IS - 23 SN - 0305-1048, 0305-1048 KW - Glucocorticoids KW - 0 KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Transfection -- drug effects KW - Glucocorticoids -- genetics KW - Simian virus 40 -- genetics KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Chloramphenicol O-Acetyltransferase -- metabolism KW - Haplorhini KW - Cell Line KW - Transcription, Genetic -- drug effects KW - DNA Replication -- drug effects KW - Enhancer Elements, Genetic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78595065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Do+transcriptional+enhancers+also+augment+DNA+replication%3F&rft.au=O%27Connor%2C+D+T%3BSubramani%2C+S&rft.aulast=O%27Connor&rft.aufirst=D&rft.date=1988-12-09&rft.volume=16&rft.issue=23&rft.spage=11207&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-06 N1 - Date created - 1989-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1967 Jun 14;26(2):365-9 [4291934] Cell. 1988 Mar 11;52(5):635-8 [3278812] J Virol. 1979 Aug;31(2):360-9 [225559] Cell. 1981 Jan;23(1):175-82 [6260373] Nature. 1981 Sep 3;293(5827):79-81 [6267479] Nucleic Acids Res. 1981 Nov 25;9(22):6047-68 [6273820] Nucleic Acids Res. 1981 Dec 11;9(23):6231-50 [6275353] Cell. 1982 Apr;28(4):767-79 [6178514] Mol Cell Biol. 1982 Sep;2(9):1044-51 [6960240] J Mol Appl Genet. 1982;1(5):457-81 [6296253] Cell. 1983 Jun;33(2):489-99 [6190571] Nature. 1984 Feb 23-29;307(5953):708-14 [6321997] Anal Biochem. 1983 Nov;135(1):1-15 [6322609] Nature. 1984 Nov 15-21;312(5991):242-6 [6095089] Nature. 1984 Nov 29-Dec 5;312(5993):409-13 [6095100] EMBO J. 1984 Dec 20;3(13):3129-33 [6098465] J Virol. 1986 Jan;57(1):138-44 [3001340] Proc Natl Acad Sci U S A. 1986 Mar;83(6):1646-50 [3006062] Mol Cell Biol. 1986 Apr;6(4):1117-28 [3023870] Mol Cell Biol. 1986 May;6(5):1663-70 [3023900] Mol Cell Biol. 1986 Sep;6(9):3086-93 [3023962] Mol Cell Biol. 1986 Oct;6(10):3513-22 [3025597] Mol Cell Biol. 1987 Feb;7(2):725-37 [3821727] EMBO J. 1987 Jan;6(1):161-8 [3034574] EMBO J. 1987 Dec 1;6(12):3771-8 [3428274] Anal Biochem. 1976 May 7;72:248-54 [942051] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A novel mechanism of soluble guanylate cyclase stimulation: time-dependent activation by bacterial lipopolysaccharide in rat fetal spleen cells. AN - 78558255; 2461743 AB - Small amounts of bacterial lipopolysaccharide (LPS) greatly increase cGMP levels in short term cultures of rat fetal liver and spleen cells in a dose and time dependent manner. To determine the role of guanylate cyclase in this response, a series of experiments was undertaken using either intact or broken fetal spleen cells, the most sensitive tissue evaluated to date. The phosphodiesterase inhibitor, 1-methyl-3-isobutyl-xanthine, potentiated the LPS-cGMP effect in cultures of these cells even at maximal doses of LPS. Moreover, after incubation of intact cells with LPS for 4 h, soluble guanylate cyclase (EC 4.6.1.2) activity was increased 2-fold, whereas particulate activity was unchanged. This increase in soluble activity was proportional to the dose of LPS, was synchronous with the elevation of cGMP levels, and was not associated with any change in cGMP-phosphodiesterase (EC 3.1.4.17) activity. In contrast to intact cells, neither total nor soluble guanylate cyclase activity was increased by the addition of LPS to spleen cell whole sonicate or cytosol for various times from 10 min to 3.5 h. These results suggest that the LPS-cGMP response is due to a persistent indirect stimulation of soluble guanylate cyclase activity that is both dose and time dependent. JF - Biochimica et biophysica acta AU - Graber, S E AU - Clancey, M A AU - Wells, J N AU - Gerzer, R AD - Department of Medicine, Veterans Administration Medical Center, Nashville, TN 37212. Y1 - 1988/12/09/ PY - 1988 DA - 1988 Dec 09 SP - 331 EP - 338 VL - 972 IS - 3 SN - 0006-3002, 0006-3002 KW - Lipopolysaccharides KW - 0 KW - Manganese KW - 42Z2K6ZL8P KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Cyclic GMP KW - H2D2X058MU KW - Magnesium KW - I38ZP9992A KW - Dithiothreitol KW - T8ID5YZU6Y KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Index Medicus KW - Animals KW - Manganese -- pharmacology KW - Liver -- enzymology KW - Cytosol -- enzymology KW - Gestational Age KW - Liver -- embryology KW - Rats KW - Cells, Cultured KW - Kinetics KW - Dithiothreitol -- pharmacology KW - Magnesium -- pharmacology KW - Enzyme Activation -- drug effects KW - Cyclic GMP -- biosynthesis KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Drug Synergism KW - Salmonella KW - Guanylate Cyclase -- metabolism KW - Lipopolysaccharides -- pharmacology KW - Spleen -- embryology KW - Spleen -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78558255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=A+novel+mechanism+of+soluble+guanylate+cyclase+stimulation%3A+time-dependent+activation+by+bacterial+lipopolysaccharide+in+rat+fetal+spleen+cells.&rft.au=Graber%2C+S+E%3BClancey%2C+M+A%3BWells%2C+J+N%3BGerzer%2C+R&rft.aulast=Graber&rft.aufirst=S&rft.date=1988-12-09&rft.volume=972&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. AN - 78550295; 2904006 AB - A double-blind, placebo-controlled study was carried out to see whether the synthetic E prostaglandin, misoprostol, would prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). 420 patients with osteoarthritis and NSAID-associated abdominal pain were studied; they were receiving ibuprofen, piroxicam, or naproxen. Endoscopy was done at entry and after 1, 2, and 3 months of continuous treatment with 100 micrograms or 200 micrograms misoprostol or placebo, given four times daily with meals and at bedtime, concurrently with the NSAID. Abdominal pain was rated independently by patients and physicians. A treatment failure was defined as development of a gastric ulcer. Gastric ulcers (0.3 cm in diameter or greater) occurred less frequently (p less than 0.001) in both misoprostol treatment groups (5.6% 100 micrograms and 1.4% 200 micrograms) than in the placebo group (21.7%). The significant difference in ulcer formation between the placebo and the misoprostol treatment groups remained when comparisons were restricted to ulcers greater than 0.5 cm in diameter (12.3% placebo, 4.2% 100 micrograms misoprostol, and 0.7% 200 micrograms misoprostol). Mild to moderate, self-limiting diarrhoea was the most frequently reported adverse effect attributed to misoprostol. These results provide the first clear indication that NSAID-induced ulcers are preventable. JF - Lancet (London, England) AU - Graham, D Y AU - Agrawal, N M AU - Roth, S H AD - Veterans Administration Medical Center, Houston, Texas. Y1 - 1988/12/03/ PY - 1988 DA - 1988 Dec 03 SP - 1277 EP - 1280 VL - 2 IS - 8623 SN - 0140-6736, 0140-6736 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Misoprostol KW - 0E43V0BB57 KW - Alprostadil KW - F5TD010360 KW - Abridged Index Medicus KW - Index Medicus KW - Probability KW - Multicenter Studies as Topic KW - Double-Blind Method KW - Random Allocation KW - Abdomen KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Pain -- prevention & control KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Female KW - Male KW - Alprostadil -- therapeutic use KW - Alprostadil -- analogs & derivatives KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Osteoarthritis -- drug therapy KW - Stomach Ulcer -- prevention & control KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78550295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Prevention+of+NSAID-induced+gastric+ulcer+with+misoprostol%3A+multicentre%2C+double-blind%2C+placebo-controlled+trial.&rft.au=Graham%2C+D+Y%3BAgrawal%2C+N+M%3BRoth%2C+S+H&rft.aulast=Graham&rft.aufirst=D&rft.date=1988-12-03&rft.volume=2&rft.issue=8623&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=01406736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-30 N1 - Date created - 1988-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Expedient surgical treatment of chronic ulcer stenosis. A case for proximal gastric vagotomy. AN - 85200711; pmid-3230277 AB - Forty-nine patients with chronic pyloroduodenal ulcer stenosis were treated surgically in our hospitals between 1977 and 1985. Three operations were used: 16 patients had a proximal gastric vagotomy-pyloroplasty (PGV-P); 26 had a vagotomy-antrectomy (V-A); and seven had a truncal vagotomy-pyloroplasty (TV-P). Historical data and preparations for operation were similar in each group. We compared the early clinical outcome in these patients. Two patients died after V-A and one died after TV-P. Five patients were reoperated: V-A (three patients), PGV-P and TV-P (one patient each). Delayed gastric emptying with nonoperative resolution (DGE) occurred in nine patients after V-A and in two patients after TV-P. Preoperative gastric suction and parenteral nutrition did not avoid DGE or affect timing of return to a general diet. A solid diet was resumed earlier (p less than 0.01) after PGV-P (5 +/- 1 days) than after V-A (13 +/- 8 days) or TV-P (9 +/- 2 days). Ninety-four percent of patients after PGV-P had an uneventful recovery, compared with 46 and 43% after V-A and TV-P, respectively. Among the variables measured, operative choice of PGV-P expedited early surgical recovery of patients with chronic ulcer stenosis. JF - Journal of Clinical Gastroenterology AU - Gleysteen, J J AU - Droege, E A AD - Surgical Service, Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin. PY - 1988 SP - 619 EP - 622 VL - 10 IS - 6 SN - 0192-0790, 0192-0790 KW - Pyloric Stenosis KW - Pylorus KW - Comparative Study KW - Postoperative Complications KW - Human KW - Retrospective Studies KW - Middle Age KW - Chronic Disease KW - Pyloric Antrum KW - Peptic Ulcer KW - Male KW - Female KW - Vagotomy, Proximal Gastric UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85200711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Expedient+surgical+treatment+of+chronic+ulcer+stenosis.+A+case+for+proximal+gastric+vagotomy.&rft.au=Gleysteen%2C+J+J%3BDroege%2C+E+A&rft.aulast=Gleysteen&rft.aufirst=J&rft.date=1988-12-01&rft.volume=10&rft.issue=6&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Reliability of spontaneous otoacoustic emission suppression tuning curve measures. AN - 85141838; pmid-3230891 AB - The purpose of this investigation was to study the reliability of spontaneous otoacoustic emission (SOAE) suppression tuning curve (STC) measurements. Two repetitions of an SOAE STC, using a 4-dB suppression criterion, were obtained from 5 subjects who exhibited stable SOAE level (SD less than or equal to 1.5 dB) and SOAE frequency (+/- 5 Hz). Analyses of variance revealed no significant difference between the SOAE STC trials (p greater than .05). The SOAE frequency was below the SOAE STC tip, which is similar to the relationship between the probe frequency and a simultaneously masked psychophysical tuning curve. The mean slope of the SOAE STC low-frequency segment was 53.7 dB/octave, whereas the mean slope of the SOAE STC high-frequency segment was 124.8 dB/octave. The mean low- to high-frequency slope ratio was 2.4. The mean Q10 value for the 5 subjects was 5.3. The SOAE STC low- and high-frequency slopes and Q10 were similar to psychophysical tuning curve data obtained in simultaneous masking and physiological tuning curve data. JF - Journal of Speech and Hearing Research AU - Zizz, C A AU - Glattke, Theodore J AD - Veterans Administration Medical Center, Long Beach, CA.; Department of Speech, Language, and Hearing Sciences, College of Science, University of Arizona PY - 1988 SP - 616 EP - 619 VL - 31 IS - 4 SN - 0022-4685, 0022-4685 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85141838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Research&rft.atitle=Reliability+of+spontaneous+otoacoustic+emission+suppression+tuning+curve+measures.&rft.au=Zizz%2C+C+A%3BGlattke%2C+Theodore+J&rft.aulast=Zizz&rft.aufirst=C&rft.date=1988-12-01&rft.volume=31&rft.issue=4&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Research&rft.issn=00224685&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation. AN - 78758382; 2907916 AB - Both alpha 1-adrenergic agonists (e.g. norepinephrine, NE*) and tumor-promoting phorbol esters (e.g. phorbol myristate acetate, PMA) are known to activate protein kinase C (PKC) (Abdel-Latif, 1986, Niedel and Blackshear, 1986). However, alpha 1 agonists and PMA produce very different effects on cardiac function (see Simpson, 1985; Benfey, 1987; Meidell et al., 1986; Leatherman et al., 1987; Yuan et al., 1987; for examples). PKC activation in heart cells has been studied only for PMA treated perfused heart (Yuan et al., 1987). Therefore, acute activation and chronic regulation of PKC by NE and PMA were compared in cultured neonatal rat heart myocytes. NE acutely and transiently activated PKC, as measured by translocation of PKC activity to the cell particulate fraction (Niedel and Blackshear, 1986). Particulate PKC activity peaked at 23% of total after NE for 30 s, as compared with 8% for control (P less than 0.001). By contrast, acute PKC activation by PMA was more pronounced and persistent, with particulate PKC activity 62% of total at 5 min (P less than 0.001). Calcium/lipid-independent kinase activity increased acutely with PMA, but not with NE. Chronic treatment with NE (24 to 48 h) increased total per cell PKC activity and 3H-phorbol dibutyrate (PDB) binding sites, an index of the number of PKC molecules (Niedel and Blackshear, 1986), by 30 to 60% over control (all P less than 0.05 to 0.01). In contrast with NE, chronic treatment with PMA down-regulated PKC, reducing total per cell PKC activity and 3H-PDB binding sites to 3% and 12% of control, respectively (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of molecular and cellular cardiology AU - Henrich, C J AU - Simpson, P C AD - Division of Cardiology, Veterans Administration Medical Center, San Francisco. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1081 EP - 1085 VL - 20 IS - 12 SN - 0022-2828, 0022-2828 KW - Adrenergic alpha-Antagonists KW - 0 KW - Receptors, Adrenergic, alpha KW - Terazosin KW - 8L5014XET7 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Norepinephrine KW - X4W3ENH1CV KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Prazosin -- analogs & derivatives KW - Cells, Cultured KW - Prazosin -- pharmacology KW - Enzyme Activation -- drug effects KW - Adrenergic alpha-Antagonists -- pharmacology KW - Protein Kinase C -- metabolism KW - Myocardium -- cytology KW - Norepinephrine -- pharmacology KW - Myocardium -- enzymology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Receptors, Adrenergic, alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78758382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+and+cellular+cardiology&rft.atitle=Differential+acute+and+chronic+response+of+protein+kinase+C+in+cultured+neonatal+rat+heart+myocytes+to+alpha+1-adrenergic+and+phorbol+ester+stimulation.&rft.au=Henrich%2C+C+J%3BSimpson%2C+P+C&rft.aulast=Henrich&rft.aufirst=C&rft.date=1988-12-01&rft.volume=20&rft.issue=12&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+and+cellular+cardiology&rft.issn=00222828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-10 N1 - Date created - 1989-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1. AN - 78749050; 2469387 AB - Since clinical trials are being planned with the immunomodulating drug isoprinosine combined with the antiviral drug 3'-azido-3'-deoxythymidine (AZT) in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex, it is important to determine the type of antiviral interaction produced by these drugs in vitro. Such a combined modality may not only produce enhanced antiviral effects but also may have a valuable immunorestorative action. The interaction of several ratios of AZT and isoprinosine on the replication of human immunodeficiency virus type 1 in human peripheral blood mononuclear cells was determined by reverse transcriptase assay of disrupted virus obtained from supernatants of cells that were exposed to virus and the drugs separately and in combination and by a human immunodeficiency virus type 1 p24 enzyme immunoassay of the same supernatants. The correlation between the reverse transcriptase and enzyme immunoassay data was high. The antiviral activity of AZT alone was neither diminished nor augmented when AZT was used in combination with isoprinosine. Isoprinosine did not enhance virus yield when used alone or in combination with AZT in peripheral blood mononuclear cells, nor did it affect the growth of uninfected cells. The in vitro results indicate that this combination did not decrease the efficacy of AZT or exacerbate virus replication. JF - Antimicrobial agents and chemotherapy AU - Schinazi, R F AU - Cannon, D L AU - Arnold, B H AU - Martino-Saltzman, D AD - Veterans Administration Medical Center, Decatur, Georgia 30033. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1784 EP - 1787 VL - 32 IS - 12 SN - 0066-4804, 0066-4804 KW - Zidovudine KW - 4B9XT59T7S KW - Inosine KW - 5A614L51CT KW - RNA-Directed DNA Polymerase KW - EC 2.7.7.49 KW - Inosine Pranobex KW - W1SO0V223F KW - Index Medicus KW - AIDS/HIV KW - Drug Interactions KW - Humans KW - RNA-Directed DNA Polymerase -- metabolism KW - Lymphocytes KW - Immunoenzyme Techniques KW - Inosine -- analogs & derivatives KW - Inosine Pranobex -- pharmacology KW - Zidovudine -- pharmacology KW - Zidovudine -- administration & dosage KW - HIV-1 -- enzymology KW - HIV-1 -- drug effects KW - Inosine Pranobex -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78749050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Combinations+of+isoprinosine+and+3%27-azido-3%27-deoxythymidine+in+lymphocytes+infected+with+human+immunodeficiency+virus+type+1.&rft.au=Schinazi%2C+R+F%3BCannon%2C+D+L%3BArnold%2C+B+H%3BMartino-Saltzman%2C+D&rft.aulast=Schinazi&rft.aufirst=R&rft.date=1988-12-01&rft.volume=32&rft.issue=12&rft.spage=1784&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1978 Jan;21(1):109-12 [563460] Drugs. 1981 Aug;22(2):111-28 [6167418] Infect Immun. 1982 Oct;38(1):243-50 [6183209] Int J Immunopharmacol. 1983;5(3):181-96 [6194125] J Immunol Methods. 1985 Jan 21;76(1):171-83 [2981931] Cancer Res. 1985 Sep;45(9 Suppl):4671s-4673s [2410111] Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100 [2413459] Lancet. 1985 Dec 21-28;2(8469-70):1423 [2417079] Drugs. 1986 Nov;32(5):383-424 [2431857] J Clin Microbiol. 1987 Jan;25(1):97-9 [2432084] Science. 1987 Mar 13;235(4794):1376-9 [2435003] Antimicrob Agents Chemother. 1987 Feb;31(2):168-72 [3471180] N Engl J Med. 1987 Jul 23;317(4):185-91 [3299089] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] Antimicrob Agents Chemother. 1987 Jun;31(6):839-43 [3304154] AIDS Res Hum Retroviruses. 1987 Spring;3(1):71-85 [2441727] Antimicrob Agents Chemother. 1987 Jul;31(7):1046-50 [2444155] Cancer Detect Prev Suppl. 1987;1:597-609 [2446760] J Med Chem. 1988 Feb;31(2):336-40 [3339606] Antimicrob Agents Chemother. 1987 Oct;31(10):1613-7 [3435108] J Infect Dis. 1988 Mar;157(3):427-31 [3278063] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In-vitro and in-vivo studies of trimethoprim-sulphamethoxazole against multiple resistant Staphylococcus aureus. AN - 78746302; 3266621 AB - Methicillin and gentamicin resistant strains of Staphylococcus aureus (MRSA) remains a cause of significant morbidity and mortality. Vancomycin is usually effective against these strains, but toxicity and expense are significant drawbacks. Resistance to the new quinolones has been demonstrated in vitro and during clinical therapeutic trials. Trimethoprim-sulphamethoxazole has proved to be effective in vitro against staphylococcal strains that are resistant to gentamicin, methicillin, and quinolones. As determined by time-kill kinetic studies, trimethoprim-sulphamethoxazole was rapidly bactericidal. Clinical evaluation of trimethoprim-sulphamethoxazole against MRSA in patients with osteomyelitis is under study. We believe that our data support the use of trimethoprim-sulphamethoxazole as a potentially economical and effective alternative for the treatment of infections caused by MRSA. JF - The Journal of antimicrobial chemotherapy AU - Yeldandi, V AU - Strodtman, R AU - Lentino, J R AD - Medical Service Section of Infectious Diseases, Edward Hines Jr Veterans Administration Hospital, Illinois 60141. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 873 EP - 880 VL - 22 IS - 6 SN - 0305-7453, 0305-7453 KW - Drug Combinations KW - 0 KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Trimethoprim KW - AN164J8Y0X KW - Sulfamethoxazole KW - JE42381TNV KW - Index Medicus KW - Humans KW - Osteomyelitis -- drug therapy KW - Drug Resistance, Microbial KW - Drug Combinations -- therapeutic use KW - Drug Combinations -- pharmacology KW - Osteomyelitis -- microbiology KW - Time Factors KW - Microbial Sensitivity Tests KW - Sulfamethoxazole -- pharmacology KW - Trimethoprim -- pharmacology KW - Trimethoprim -- therapeutic use KW - Staphylococcus aureus -- drug effects KW - Sulfamethoxazole -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78746302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=In-vitro+and+in-vivo+studies+of+trimethoprim-sulphamethoxazole+against+multiple+resistant+Staphylococcus+aureus.&rft.au=Yeldandi%2C+V%3BStrodtman%2C+R%3BLentino%2C+J+R&rft.aulast=Yeldandi&rft.aufirst=V&rft.date=1988-12-01&rft.volume=22&rft.issue=6&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - New antagonists of LHRH. II. Inhibition and potentiation of LHRH by closely related analogues. AN - 78745935; 2469662 AB - Modifications of the previously described LHRH antagonists, [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Trp3, D-Cit6, D-Ala10]LHRH and the corresponding D-Hci6 analogue, have been made to alter the hydrophobicity of the N-terminal acetyl-tripeptide portion. Substitution of D-Trp3 with the less hydrophobic D-Pal(3) had only marginal effects on the antagonistic activities and receptor binding potencies of the D-Cit/D-Hci6 analogues, but it appeared to further improve the toxicity lowering effect of D-Cit/D-Hci6 substitution. Antagonists containing D-Pal(3)3 and D-Cit/D-Hci6 residues, i.e. [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Cit6, D-Ala10]LHRH (SB-75) and [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Hci6, D-Ala10]LHRH (SB-88), were completely free of the toxic effects, such as cyanosis and respiratory depression leading to death, which have been observed in rats with the D-Trp3, D-Arg6 antagonist and related antagonists. Replacement of the N-acetyl group with the hydrophilic carbamoyl group caused a slight decrease in antagonistic activities, particularly in vitro. Introduction of urethane type acyl group such as methoxycarbonyl (Moc) or t-butoxycarbonyl (Boc) led to analogues that showed LHRH-potentiating effect. The increase in potency induced by these analogues, e.g. [Moc-D-Nal(2)1, D-Phe(4Cl)2, D-Trp3, D-Cit6, D-Ala10]LHRH and [Boc-D-Phe1, D-Phe(4Cl)2, D-Pal(3)3, D-Cit6, D-Ala10]LHRH, was 170-260% and persisted for more than 2 h when studied in a superfused rat pituitary system. JF - International journal of peptide and protein research AU - Bajusz, S AU - Csernus, V J AU - Janaky, T AU - Bokser, L AU - Fekete, M AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 425 EP - 435 VL - 32 IS - 6 SN - 0367-8377, 0367-8377 KW - Indicators and Reagents KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - Rats KW - Ovulation -- drug effects KW - Luteinizing Hormone -- secretion KW - Animals KW - Mast Cells -- physiology KW - Pituitary Gland -- secretion KW - Mast Cells -- drug effects KW - Female KW - Structure-Activity Relationship KW - Pituitary Gland -- drug effects KW - Histamine Release -- drug effects KW - Gonadotropin-Releasing Hormone -- chemical synthesis KW - Gonadotropin-Releasing Hormone -- antagonists & inhibitors KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78745935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+peptide+and+protein+research&rft.atitle=New+antagonists+of+LHRH.+II.+Inhibition+and+potentiation+of+LHRH+by+closely+related+analogues.&rft.au=Bajusz%2C+S%3BCsernus%2C+V+J%3BJanaky%2C+T%3BBokser%2C+L%3BFekete%2C+M%3BSchally%2C+A+V&rft.aulast=Bajusz&rft.aufirst=S&rft.date=1988-12-01&rft.volume=32&rft.issue=6&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=International+journal+of+peptide+and+protein+research&rft.issn=03678377&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-15 N1 - Date created - 1989-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analogs of 5-methylthioribose, a novel class of antiprotozoal agents. AN - 78743161; 2854458 AB - Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells. To exploit this metabolic difference, two analogs of methylthioribose (MTR), an MTA catabolite, were synthesized and found to be cytocidal to Plasmodium falciparum, Giardia lamblia, and Ochromonas malhamensis in vitro. In contrast, these analogs had no effect on cultured mammalian cells. Analogs of MTR represent a potential new class of antiprotozoal drugs. JF - Antimicrobial agents and chemotherapy AU - Riscoe, M K AU - Ferro, A J AU - Fitchen, J H AD - Medical Research Service, Portland Veterans Administration Medical Center, Oregon 97207. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1904 EP - 1906 VL - 32 IS - 12 SN - 0066-4804, 0066-4804 KW - Antiprotozoal Agents KW - 0 KW - Thioglycosides KW - 5-methylthioribose KW - 23656-67-9 KW - Phosphotransferases KW - EC 2.7.- KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - 5-methylthioribose kinase KW - EC 2.7.1.100 KW - Index Medicus KW - Animals KW - Phosphotransferases -- antagonists & inhibitors KW - Eukaryota -- enzymology KW - Antiprotozoal Agents -- pharmacology KW - Thioglycosides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78743161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Analogs+of+5-methylthioribose%2C+a+novel+class+of+antiprotozoal+agents.&rft.au=Riscoe%2C+M+K%3BFerro%2C+A+J%3BFitchen%2C+J+H&rft.aulast=Riscoe&rft.aufirst=M&rft.date=1988-12-01&rft.volume=32&rft.issue=12&rft.spage=1904&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1981 Sep 16;102(1):302-7 [6796086] Trans R Soc Trop Med Hyg. 1981;75(2):263-7 [7029800] Biochem Biophys Res Commun. 1982 Sep 16;108(1):167-73 [6293478] N Engl J Med. 1983 Apr 14;308(15):875-8 [6339920] Methods Enzymol. 1983;94:361-4 [6312270] J Biol Chem. 1984 May 10;259(9):5465-71 [6425290] Parasitology. 1985 Apr;90 ( Pt 4):705-15 [3892439] J Parasitol. 1986 Feb;72(1):45-61 [3519918] Biochem J. 1969 Nov;115(2):241-7 [5378381] Can J Biochem. 1971 Feb;49(2):262-70 [5545262] J Cell Physiol. 1971 Oct;78(2):301-17 [4333458] Biochim Biophys Acta. 1973 Sep 14;320(2):357-62 [4796087] J Org Chem. 1976 Feb 6;41(3):565-7 [1245911] Arch Microbiol. 1976 Jun;108(2):175-82 [945048] Science. 1976 Aug 20;193(4254):673-5 [781840] Biochim Biophys Acta. 1976 Jul 8;438(2):487-94 [782530] Blood. 1977 Apr;49(4):573-83 [300256] J Med Chem. 1977 Apr;20(4):500-5 [850235] J Biol Chem. 1978 Sep 10;253(17):6021-5 [210167] Antimicrob Agents Chemother. 1979 Dec;16(6):710-8 [394674] J Biol Chem. 1981 Feb 25;256(4):1533-5 [7007366] Biochem Pharmacol. 1982 Feb 1;31(3):277-88 [6803807] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Self-ratings of memory dysfunction: different findings in depression and amnesia. AN - 78708814; 3235647 AB - An 18-item self-rating test of memory functions was administered to two patient groups: seven patients with amnesia resulting from Korsakoff's syndrome and six other amnesic patients. These results were compared to results obtained previously for depressed psychiatric inpatients (n = 19) and depressed inpatients prescribed electroconvulsive therapy (ECT) (n = 35). The latter group was tested both before and 1 week after completion of the course of ECT. One pattern of memory self-ratings was reported by the two groups of depressed patients. These two groups reported an approximately equivalent level of impairment across all test items. A different pattern of memory self-ratings was reported by the two groups of amnesic patients and by the group tested after ECT. These patients reported considerably more impairment on some items than others, such that performance was not equivalent across test items. Finally, the patients with Korsakoff's syndrome underestimated their memory problems, reporting a less severe impairment than the other amnesic patients. The results show that the memory problems experienced in depression and in amnesia are distinguishable with self-assessment techniques. In addition, the similarity between memory self-ratings reported by patients after ECT and by amnesic patients supports the idea that memory complaints after ECT reflect primarily the experience of amnesia. Self-rating forms like the one described here may have useful application to many diagnostic groups where questions arise about the nature of reported memory problems. JF - Journal of clinical and experimental neuropsychology AU - Squire, L R AU - Zouzounis, J A AD - Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 727 EP - 738 VL - 10 IS - 6 SN - 1380-3395, 1380-3395 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Electroconvulsive Therapy KW - Neuropsychological Tests KW - Male KW - Female KW - Memory KW - Depressive Disorder -- psychology KW - Alcohol Amnestic Disorder -- psychology KW - Mental Recall KW - Amnesia -- psychology KW - Depressive Disorder -- therapy KW - Brain Damage, Chronic -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78708814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+and+experimental+neuropsychology&rft.atitle=Self-ratings+of+memory+dysfunction%3A+different+findings+in+depression+and+amnesia.&rft.au=Squire%2C+L+R%3BZouzounis%2C+J+A&rft.aulast=Squire&rft.aufirst=L&rft.date=1988-12-01&rft.volume=10&rft.issue=6&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+and+experimental+neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-28 N1 - Date created - 1989-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AAEE case report #16: Botulism. AN - 78708233; 3070381 AB - Botulinal toxin causes a marked reduction in the number of quanta released by autonomic and motor nerve terminals. As a result it causes blurred vision, inability to move the eyes, weakness of other cranial nerve-innervated muscles, dyspnea progressing to apnea, and generalized weakness. Electrodiagnostic findings in severe botulism can be relatively nonspecific, with low amplitude and short duration motor unit action potentials and small M wave amplitudes. A modest increment in M wave amplitude with rapid repetitive nerve stimulation may help to localize the disorder to the neuromuscular junction. Identification of the toxin in the patient's serum is diagnostic. The treatment of botulism is mainly supportive. JF - Muscle & nerve AU - Pickett, J B AD - Department of Neurology, Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1201 EP - 1205 VL - 11 IS - 12 SN - 0148-639X, 0148-639X KW - Index Medicus KW - Humans KW - Electrodiagnosis KW - Adolescent KW - Male KW - Botulism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78708233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+nerve&rft.atitle=AAEE+case+report+%2316%3A+Botulism.&rft.au=Pickett%2C+J+B&rft.aulast=Pickett&rft.aufirst=J&rft.date=1988-12-01&rft.volume=11&rft.issue=12&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+nerve&rft.issn=0148639X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Is malnutrition necessary for the development of alcoholic fatty liver in the rat? AN - 78674067; 3226358 AB - Ingestion of various liquid diets containing 36% calories as ethanol and 35% calories as fat does not provide adequate nutrition to young growing rats. Studies conducted with the aforementioned diets have the effects of malnutrition confounded with those of alcohol administration. Feeding a 26% alcohol liquid diet, which results in adequate nutrient intake with the same level of alcohol ingestion as the 36% alcohol diet, does not result in fatty liver development in the rat. The concept that prevailed for 25 years that fatty liver is caused despite adequate nutrition and hence is due to alcohol alone is therefore erroneous. JF - Medical hypotheses AU - Derr, R F AU - Larkin, E C AU - Rao, G A AD - Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 277 EP - 280 VL - 27 IS - 4 SN - 0306-9877, 0306-9877 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Ethanol -- administration & dosage KW - Disease Models, Animal KW - Diet -- adverse effects KW - Fatty Liver, Alcoholic -- etiology KW - Nutrition Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78674067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=Is+malnutrition+necessary+for+the+development+of+alcoholic+fatty+liver+in+the+rat%3F&rft.au=Derr%2C+R+F%3BLarkin%2C+E+C%3BRao%2C+G+A&rft.aulast=Derr&rft.aufirst=R&rft.date=1988-12-01&rft.volume=27&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=03069877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-05 N1 - Date created - 1989-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Insulin and C-peptide in ascitic fluid and plasma and their relative responses to glucagon in patients with cirrhosis. AN - 78669808; 3066813 AB - Insulin (IRI) and C-peptide dynamics were studied after iv glucagon in 5 nondiabetic patients with ascites due to cirrhosis of the liver. Plasma and ascitic fluid samples for glucose, IRI and C-peptide determinations were obtained before and 6, 10, 15, 20 and 30 min after glucagon injection. Ascitic fluid volumes, estimated by dilution of ip injected PAH, were 6.2 to 20.5 L. The mean fasting plasma glucose [88 +/- 6.7 mg/dl (SE)] and C-peptide (1.40 +/- 0.42 ng/ml) levels were normal; mean plasma insulin was increased (17.4 +/- 3.0 microU/ml). After glucagon injection, there was a subnormal rise in plasma glucose (PG) compared to 5 mild diabetic patients without liver disease (8.4 +/- 3.5 vs 76 +/- 7.4 mg/dl). The plasma C-peptide rise was less than that of plasma IRI (54% vs 192%). The mean basal ascitic fluid concentration of glucose was 86 +/- 9.4 mg/dl, IRI 13.2 +/- 2.9 microU/ml and C-peptide 3.09 +/- 0.49 ng/ml. Total calculated basal ascitic fluid contents of glucose was 5.2-23.3 g, IRI 47, 120-290,000 microU and C-peptide 15,750-66,420 ng. These were 3-10 times the quantity of these substances circulating in the plasma volume. After glucagon injection, there was no significant increase in ascitic fluid glucose or IRI, but there was a 43% increase in C-peptide concentration at 10 min. In ascitic fluid, the molar concentration of IRI was lower and C-peptide higher than plasma, resulting in a C-peptide: IRI molar ratio of 11.31, markedly higher than the published normal plasma ratio of 4.63.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of endocrinological investigation AU - Akgün, S AU - Samanta, A AU - Ertel, N H AD - Medical Service, Veterans Administration Medical Center, East Orange, New Jersey 07019. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 789 EP - 793 VL - 11 IS - 11 SN - 0391-4097, 0391-4097 KW - Blood Glucose KW - 0 KW - C-Peptide KW - Insulin KW - Glucagon KW - 9007-92-5 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Blood Glucose -- metabolism KW - Kinetics KW - Humans KW - Glucose -- metabolism KW - Adult KW - Middle Aged KW - Male KW - C-Peptide -- metabolism KW - Liver Cirrhosis, Alcoholic -- metabolism KW - C-Peptide -- blood KW - Insulin -- blood KW - Insulin -- metabolism KW - Ascitic Fluid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78669808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+endocrinological+investigation&rft.atitle=Insulin+and+C-peptide+in+ascitic+fluid+and+plasma+and+their+relative+responses+to+glucagon+in+patients+with+cirrhosis.&rft.au=Akg%C3%BCn%2C+S%3BSamanta%2C+A%3BErtel%2C+N+H&rft.aulast=Akg%C3%BCn&rft.aufirst=S&rft.date=1988-12-01&rft.volume=11&rft.issue=11&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Journal+of+endocrinological+investigation&rft.issn=03914097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-29 N1 - Date created - 1989-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis. AN - 78627211; 3214536 AB - The effect of bilateral nucleus basalis magnocellularis (nBM) lesions on performance in the Morris water task was examined in the rat, and the ability of anticholinesterase inhibitors to reverse the behavioral deficit was evaluated. Lesions of nBM resulted in a prolongation of escape latency. A spatial probe trial revealed that animals with sham lesions swam a greater percentage of the distance in the platform quadrant; this finding was abolished by nBM lesions. Lesions of nBM produced a nonsignificant increase in both open-field activity and activity-box scores. In Experiment 1, administration of 0.32 mg/kg physostigmine on Day 3 only resulted in a decrease in escape latency. In Experiment 2, in which cholinesterase inhibitors were administered daily for 5 days, 0.32 mg/kg but not low-dose physostigmine or two substituted N,N-alkyl phenyl carbamate cholinesterase inhibitors (RA-6 and RA-7) again improved escape latency on Day 3. Thus it was concluded that nBM lesions impair behavior on the Morris water task and physostigmine shortens escape latency. JF - Behavioral neuroscience AU - Dokla, C P AU - Thal, L J AD - Neurology Service, San Diego Veterans Administration Medical Center, California 92161. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 861 EP - 871 VL - 102 IS - 6 SN - 0735-7044, 0735-7044 KW - Carbamates KW - 0 KW - Cholinesterase Inhibitors KW - Phenylcarbamates KW - N,N-methylethylphenylcarbamate KW - 135467-93-5 KW - Ibotenic Acid KW - 2552-55-8 KW - Urethane KW - 3IN71E75Z5 KW - Physostigmine KW - 9U1VM840SP KW - Index Medicus KW - Rats KW - Carbamates -- pharmacology KW - Reaction Time -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Physostigmine -- pharmacology KW - Urethane -- analogs & derivatives KW - Motor Activity -- drug effects KW - Urethane -- pharmacology KW - Male KW - Ibotenic Acid -- pharmacology KW - Discrimination Learning -- drug effects KW - Cholinesterase Inhibitors -- pharmacology KW - Orientation -- drug effects KW - Substantia Innominata -- drug effects KW - Escape Reaction -- drug effects KW - Basal Ganglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78627211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Effect+of+cholinesterase+inhibitors+on+Morris+water+task+behavior+following+lesions+of+the+nucleus+basalis+magnocellularis.&rft.au=Dokla%2C+C+P%3BThal%2C+L+J&rft.aulast=Dokla&rft.aufirst=C&rft.date=1988-12-01&rft.volume=102&rft.issue=6&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-06 N1 - Date created - 1989-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nucleus basalis magnocellularis lesions: lack of biochemical and immunocytochemical recovery and effect of cholinesterase inhibitors on passive avoidance. AN - 78623566; 3214535 AB - Lesions of the rat nucleus basalis magnocellularis (nBM) result in a marked decrease in cortical choline acetyltransferase (CAT) and in behavioral deficits. After unilateral ibotenic acid (IBO) lesions of the nBM in rats, there was a significant ipsilateral loss of frontal and parietal CAT, which did not recover for 3 months following surgery and was accompanied by a loss of CAT immunoreactivity in the peripallidal region. Bilateral ibotenate nBM lesions resulted in a marked deficit of one-trial step-through passive avoidance (PA) at 24 hours. Cholinesterase inhibitors including physostigmine, N-ethylaklylphenyl carbamate (RA-6), and N,N-methylethylphenyl carbamate (RA-7) were administered in separate experiments, for 2 days before retrieval testing or for 3 consecutive days during consolidation immediately following training. Nonsignificant improvements in PA latency were produced using 0.32 mg/kg physostigmine and 2.5 mg/kg RA-6 administered before retrieval testing. The results suggest that destruction of cholinergic neurons in the nBM are involved in the PA deficit, but does not exclude the possibility that damage to other neuronal systems may contribute to the observed behavioral deficit. JF - Behavioral neuroscience AU - Thal, L J AU - Dokla, C P AU - Armstrong, D M AD - Neurology Service, San Diego Veterans Administration Medical Center, California 92161. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 852 EP - 860 VL - 102 IS - 6 SN - 0735-7044, 0735-7044 KW - Carbamates KW - 0 KW - Cholinesterase Inhibitors KW - Phenylcarbamates KW - N,N-methylethylphenylcarbamate KW - 135467-93-5 KW - Ibotenic Acid KW - 2552-55-8 KW - Urethane KW - 3IN71E75Z5 KW - Physostigmine KW - 9U1VM840SP KW - Choline O-Acetyltransferase KW - EC 2.3.1.6 KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Index Medicus KW - Rats KW - Carbamates -- pharmacology KW - Animals KW - Rats, Inbred F344 KW - Brain Mapping KW - Physostigmine -- pharmacology KW - Acetylcholinesterase -- metabolism KW - Urethane -- analogs & derivatives KW - Urethane -- pharmacology KW - Immunohistochemistry KW - Male KW - Ibotenic Acid -- pharmacology KW - Cholinesterase Inhibitors -- pharmacology KW - Substantia Innominata -- drug effects KW - Avoidance Learning -- drug effects KW - Choline O-Acetyltransferase -- antagonists & inhibitors KW - Choline O-Acetyltransferase -- metabolism KW - Basal Ganglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78623566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Nucleus+basalis+magnocellularis+lesions%3A+lack+of+biochemical+and+immunocytochemical+recovery+and+effect+of+cholinesterase+inhibitors+on+passive+avoidance.&rft.au=Thal%2C+L+J%3BDokla%2C+C+P%3BArmstrong%2C+D+M&rft.aulast=Thal&rft.aufirst=L&rft.date=1988-12-01&rft.volume=102&rft.issue=6&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-06 N1 - Date created - 1989-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Uroporphyrin accumulation in cultured chick embryo hepatocytes: comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,4,3',4'-tetrachlorobiphenyl. AN - 78598454; 3144777 AB - Uroporphyrin (URO) accumulation caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3,4,3',4'-tetrachlorobiphenyl (TCB) in cultured chick embryo hepatocytes was found to depend on the concentration of the added polyhalogenated aromatic compound, and on either the addition of 5-aminolevulinic acid or the induction of 5-aminolevulinic acid synthase. TCDD alone did not cause more than a slight increase in uroporphyrin, whereas TCB alone caused considerable uroporphyrin accumulation associated with increased 5-aminolevulinic acid synthase activity. However, in the presence of exogenous 5-aminolevulinic acid, TCDD was more potent than TCB in causing uroporphyrin accumulation. The concentrations of TCDD or TCB which maximally induced ethoxyresorufin deethylase activity, an indicator of induced cytochrome P450 activity, were lower than those required for maximal uroporphyrin accumulation. Furthermore, ethoxyresorufin deethylase activity was found to decline at concentrations of TCDD or TCB which caused maximum uroporphyrin accumulation. Pretreatment with 3-methylcholanthrene enhanced uroporphyrin accumulation, whereas addition of inhibitors of cytochrome P450 decreased uroporphyrin accumulation. Uroporphyrin accumulation occurred without a decrease in uroporphyrinogen decarboxylase activity, and was unrelated to the degree of conversion of the polyhalogenated aromatic compounds to water-soluble metabolites. Our results indicate that URO accumulation caused by TCDD and TCB requires two separate actions; (1) induction of cytochrome P450 which occurs at low concentrations of the halogenated chemicals, and (2) increased uroporphyrinogen oxidation which is catalyzed by the induced cytochrome P450 and which occurs at higher concentrations of the halogenated chemicals. JF - Toxicology and applied pharmacology AU - Lambrecht, R W AU - Sinclair, P R AU - Bement, W J AU - Sinclair, J F AD - Veterans Administration, White River Junction, Vermont 05001. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 507 EP - 516 VL - 96 IS - 3 SN - 0041-008X, 0041-008X KW - Dioxins KW - 0 KW - Polychlorinated Dibenzodioxins KW - Porphyrins KW - Uroporphyrins KW - Heme KW - 42VZT0U6YR KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Uroporphyrinogen Decarboxylase KW - EC 4.1.1.37 KW - 3,4,3',4'-tetrachlorobiphenyl KW - Y2I6546TMI KW - Index Medicus KW - Heme -- biosynthesis KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Chick Embryo KW - Cytochrome P-450 Enzyme System -- physiology KW - Uroporphyrinogen Decarboxylase -- analysis KW - Porphyrins -- metabolism KW - Uroporphyrins -- metabolism KW - Liver -- drug effects KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Dibenzodioxins -- toxicity KW - Liver -- metabolism KW - Dioxins -- toxicity KW - Polychlorinated Dibenzodioxins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78598454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Uroporphyrin+accumulation+in+cultured+chick+embryo+hepatocytes%3A+comparison+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+and+3%2C4%2C3%27%2C4%27-tetrachlorobiphenyl.&rft.au=Lambrecht%2C+R+W%3BSinclair%2C+P+R%3BBement%2C+W+J%3BSinclair%2C+J+F&rft.aulast=Lambrecht&rft.aufirst=R&rft.date=1988-12-01&rft.volume=96&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-03 N1 - Date created - 1989-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational sensitivity to Alphitobius diaperinus (Panzer) (lesser mealworm). AN - 78589435; 2462582 AB - Alphitobius diaperinus is an important beetle in the grain and poultry industries. We evaluated three individuals with work-related symptoms of asthma, rhinitis, conjunctivitis, urticaria, and angioedema on exposure to the insect. Prick skin tests with extracts prepared from the larval, pupal, and adult life stages were positive in all three patients. Specific IgE antibodies to these extracts were demonstrated by RAST or radioimmunoassay. RAST and radioimmunoassay inhibition confirmed the specificity of IgE binding and further demonstrated immunologic cross-reactivity between the three life stages. Peripheral blood leukocytes from two of the individuals demonstrated significant histamine release when they were compared with cells from nonexposed atopic and normal control subjects. The proteins in the extracts of each life stage were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. More than 30 protein bands were detected in each of the extracts; however, the patterns of separation were different for each life stage. After immunoblotting and autoradiography, IgE-binding proteins were recognized by sera from all three individuals in the larval extract at 90 kilodaltons (kd), in the pupal extract at 90, 64, and 38 kd, and in the adult extract at 84 kd. Additionally, several other proteins were identified as being allergenic in some of the patients. We conclude that these three patients developed IgE-mediated sensitivity to A. diaperinus antigens as the result of occupational exposure. To our knowledge, this is the first description of sensitivity to this grain beetle. JF - The Journal of allergy and clinical immunology AU - Schroeckenstein, D C AU - Meier-Davis, S AU - Graziano, F M AU - Falomo, A AU - Bush, R K AD - Allergy Section, William S. Middleton Veterans Administration Hospital, Madison, WI 53705. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1081 EP - 1088 VL - 82 IS - 6 SN - 0091-6749, 0091-6749 KW - Allergens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Immunoblotting KW - Electrophoresis, Polyacrylamide Gel KW - Skin Tests KW - Humans KW - Radioimmunoassay KW - Radioallergosorbent Test KW - Adult KW - Binding, Competitive KW - Histamine Release KW - Allergens -- analysis KW - Female KW - Male KW - Occupational Diseases -- diagnosis KW - Hypersensitivity, Immediate -- etiology KW - Occupational Diseases -- etiology KW - Hypersensitivity, Immediate -- diagnosis KW - Beetles -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78589435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Occupational+sensitivity+to+Alphitobius+diaperinus+%28Panzer%29+%28lesser+mealworm%29.&rft.au=Schroeckenstein%2C+D+C%3BMeier-Davis%2C+S%3BGraziano%2C+F+M%3BFalomo%2C+A%3BBush%2C+R+K&rft.aulast=Schroeckenstein&rft.aufirst=D&rft.date=1988-12-01&rft.volume=82&rft.issue=6&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-06 N1 - Date created - 1989-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Linear dimensional changes in dental impressions after immersion in disinfectant solutions. AN - 78589048; 3060605 JF - The Journal of prosthetic dentistry AU - Tullner, J B AU - Commette, J A AU - Moon, P C AD - Veterans Administration Medical Center, Hampton, Va. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 725 EP - 728 VL - 60 IS - 6 SN - 0022-3913, 0022-3913 KW - Dental Impression Materials KW - 0 KW - Dentistry KW - Index Medicus KW - AIDS/HIV KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Hepatitis B -- prevention & control KW - Chemistry, Physical KW - Humans KW - Occupational Diseases -- prevention & control KW - Chemical Phenomena KW - Disinfection KW - Dental Impression Technique KW - Sterilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78589048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+prosthetic+dentistry&rft.atitle=Linear+dimensional+changes+in+dental+impressions+after+immersion+in+disinfectant+solutions.&rft.au=Tullner%2C+J+B%3BCommette%2C+J+A%3BMoon%2C+P+C&rft.aulast=Tullner&rft.aufirst=J&rft.date=1988-12-01&rft.volume=60&rft.issue=6&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+prosthetic+dentistry&rft.issn=00223913&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-30 N1 - Date created - 1989-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Leukotriene D4 potentiates the contractile effects of epinephrine and norepinephrine on rat aortic rings. AN - 78588998; 2849678 AB - Previous studies have demonstrated a cooperative interaction between peptido-leukotrienes (LTs) and epinephrine (EPI) relative to induction of platelet aggregation and thromboxane formation. To examine if a similar interaction occurs in arteries, we studied the effects of LTD4 and EPI as well as norepinephrine (NOREPI) on isolated rat aortic rings. LTD4 alone (mean concentration 2 x 10(-7) M) induced contraction in 10 of 15 rings examined (mean peak tension 0.31 +/- 0.27 g/mg of tissue). However, pretreatment of aortic rings with LTD4 (10(-7) M) consistently and significantly enhanced the contractile effects of EPI and NOREPI and lowered the threshold concentration of these agonists required to evoke contraction from 4 x 10(-9) to 3 x 10(-10) M (P less than .05). This enhancement of the sensitivity of aortic rings by LTD4 was not observed when KCl or 5-hydroxytryptamine was used as agonists. Furthermore, the LTD4-induced potentiation of effects of EPI or NOREPI on aortic contraction was blocked by the LT-receptor antagonist FPL-55712, but not by indomethacin. These data suggest a specific cooperative contractile effect of LTD4 and alpha adrenergic agonists on rat aortic rings. This LTD4 potentiation of vascular contraction is mediated through LT-receptor stimulation and not through release of cyclooxygenase metabolites. JF - The Journal of pharmacology and experimental therapeutics AU - Lawson, D L AU - Smith, C AU - Mehta, J L AU - Mehta, P AU - Nichols, W W AD - Veterans Administration Medical Center, Gainesville, Florida. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 953 EP - 957 VL - 247 IS - 3 SN - 0022-3565, 0022-3565 KW - SRS-A KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Potassium Chloride KW - 660YQ98I10 KW - Leukotriene E4 KW - 75715-89-8 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Serotonin -- pharmacology KW - Animals KW - Aorta -- drug effects KW - Potassium Chloride -- pharmacology KW - In Vitro Techniques KW - Dogs KW - Drug Synergism KW - SRS-A -- pharmacology KW - Norepinephrine -- pharmacology KW - Epinephrine -- pharmacology KW - SRS-A -- analogs & derivatives KW - Vasoconstriction -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78588998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Leukotriene+D4+potentiates+the+contractile+effects+of+epinephrine+and+norepinephrine+on+rat+aortic+rings.&rft.au=Lawson%2C+D+L%3BSmith%2C+C%3BMehta%2C+J+L%3BMehta%2C+P%3BNichols%2C+W+W&rft.aulast=Lawson&rft.aufirst=D&rft.date=1988-12-01&rft.volume=247&rft.issue=3&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-31 N1 - Date created - 1989-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Venous complications of sclerotherapy for esophageal varices. AN - 78587950; 3264465 AB - Although endoscopic sclerotherapy is effective in controlling bleeding from esophageal varices, the effects of sclerosing agents on the extrahepatic portal and splenic veins have not previously been investigated. This study of 21 men with portal hypertension and variceal bleeding compares the morphology of the portal and splenic veins in 11 who had received endoscopic sclerotherapy versus 10 patients who did not. The mean number of injections per patient was 11 +/- 5, the mean volume of 1.5 percent sodium tetradecyl injected was 23 +/- 15 ml, and the interval between the last injection and surgery was 15 +/- 6.5 days. Among the 11 patients who had endoscopic sclerotherapy, portal vein thrombosis occurred in 4 (36 percent). Two of these patients died from acute liver failure; the other two had shunt procedures. Histologic changes included intimal thickening and medial fibrosis in seven patients, thrombus in four patients, and destruction of the venous architecture in two patients. Of the 10 patients with portal hypertension who did not have endoscopic sclerotherapy, all had medial fibrosis of the portal vein, with thrombus and intimal thickening present in only 1. These findings suggest that endoscopic sclerotherapy for esophageal varices should be used cautiously in patients who may later require a shunt. Moreover, further studies are necessary to evaluate the long-term effects of injecting sclerosing agents into the portal circulation before widespread use of prophylactic sclerotherapy can be recommended. JF - American journal of surgery AU - Hunter, G C AU - Steinkirchner, T AU - Burbige, E J AU - Guernsey, J M AU - Putnam, C W AD - Department of Surgery, Veterans Administration Medical Center, Martinez, California. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 497 EP - 501 VL - 156 IS - 6 SN - 0002-9610, 0002-9610 KW - Myristic Acids KW - 0 KW - Sclerosing Solutions KW - Myristic Acid KW - 0I3V7S25AW KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Hypertension, Portal -- complications KW - Male KW - Esophageal and Gastric Varices -- therapy KW - Portal Vein -- pathology KW - Sclerosing Solutions -- adverse effects KW - Gastrointestinal Hemorrhage -- therapy KW - Glucose -- therapeutic use KW - Portal Vein -- drug effects KW - Myristic Acids -- therapeutic use KW - Gastrointestinal Hemorrhage -- etiology KW - Splenic Vein -- drug effects KW - Esophageal and Gastric Varices -- complications KW - Glucose -- adverse effects KW - Splenic Vein -- pathology KW - Myristic Acids -- adverse effects KW - Sclerosing Solutions -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78587950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+surgery&rft.atitle=Venous+complications+of+sclerotherapy+for+esophageal+varices.&rft.au=Hunter%2C+G+C%3BSteinkirchner%2C+T%3BBurbige%2C+E+J%3BGuernsey%2C+J+M%3BPutnam%2C+C+W&rft.aulast=Hunter&rft.aufirst=J&rft.date=1989-01-01&rft.volume=9&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin A treatment of sexual dysfunction in male alcoholics. AN - 78582334; 3202091 AB - Thirty abstinent male alcoholics with sexual dysfunction were randomized to treatment with 3 mg RE (10,000 IU) vitamin A or placebo daily for 4 mo. Age, drinking history, period of abstinence before enrollment, and base-line laboratory indices were comparable in both groups at entry. Of the 15 subjects given placebo, 13 had a partial or full recovery of sexual functioning. By contrast, of those given vitamin A, 10 had a partial response. There were no complete responders. Six subjects (1 placebo, 5 vitamin A) who developed liver abnormalities during treatment underwent liver biopsies; five had fibrosis or cirrhosis. A significant decrease in luteinizing hormone was noted in the group given vitamin A compared with the placebo-treated group. Thus vitamin A therapy did not improve sexual functioning in male alcoholics and may have been associated with toxicity. JF - The American journal of clinical nutrition AU - Worner, T M AU - Gordon, G G AU - Leo, M A AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1431 EP - 1435 VL - 48 IS - 6 SN - 0002-9165, 0002-9165 KW - Prealbumin KW - 0 KW - Retinol-Binding Proteins KW - Vitamin A KW - 11103-57-4 KW - Abridged Index Medicus KW - Index Medicus KW - Liver -- pathology KW - Prospective Studies KW - Humans KW - Retinol-Binding Proteins -- analysis KW - Middle Aged KW - Prealbumin -- blood KW - Male KW - Vitamin A -- therapeutic use KW - Sexual Dysfunction, Physiological -- etiology KW - Alcoholism -- complications KW - Sexual Dysfunction, Physiological -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78582334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Vitamin+A+treatment+of+sexual+dysfunction+in+male+alcoholics.&rft.au=Worner%2C+T+M%3BGordon%2C+G+G%3BLeo%2C+M+A%3BLieber%2C+C+S&rft.aulast=Worner&rft.aufirst=T&rft.date=1988-12-01&rft.volume=48&rft.issue=6&rft.spage=1431&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-17 N1 - Date created - 1989-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - GHRF causes biphasic stimulation of SRIF secretion from rat hypothalamic cells. AN - 78576357; 2904766 AB - The complex interactions of the hypothalamic releasing peptides somatostatin (SRIF) and growth hormone (GH)-releasing hormone (GHRF), which regulate GH secretion, are still incompletely understood. To further scrutinize these interactions, we have studied the effects of GHRF on SRIF secretion from dispersed adult rat hypothalamic cells. Rat GHRF caused calcium- and dose-dependent stimulation of SRIF release in static 1-h incubations. SRIF release was stimulated by GHRF in a concentration range of 1-100 nM. However, the extended dose-response curve was biphasic in nature, with a significantly lower SRIF response in the presence of 1 microM GHRF vs. 100 nM GHRF. SRIF release, stimulated by another secretagogue (10 microM veratridine), was not affected by the presence or absence of 1 microM GHRF, suggesting the lack of toxic impairment of hypothalamic cell function by GHRF at this concentration. In conclusion, a biphasic stimulatory pattern of SRIF secretion in response to GHRF was observed in experiments employing dispersed rat hypothalamic cells. The biphasic SRIF response pattern to GHRF may be relevant in the physiological regulation of GH secretion. JF - The American journal of physiology AU - Richardson, S AU - Twente, S AU - Audhya, T AD - Department of Medicine, Veterans Administration Medical Center, New York, New York. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - E829 EP - E832 VL - 255 IS - 6 Pt 1 SN - 0002-9513, 0002-9513 KW - Somatostatin KW - 51110-01-1 KW - Growth Hormone-Releasing Hormone KW - 9034-39-3 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Reference Values KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Homeostasis KW - Male KW - Somatostatin -- secretion KW - Hypothalamus -- secretion KW - Growth Hormone-Releasing Hormone -- pharmacology KW - Hypothalamus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78576357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=GHRF+causes+biphasic+stimulation+of+SRIF+secretion+from+rat+hypothalamic+cells.&rft.au=Richardson%2C+S%3BTwente%2C+S%3BAudhya%2C+T&rft.aulast=Richardson&rft.aufirst=S&rft.date=1988-12-01&rft.volume=255&rft.issue=6+Pt+1&rft.spage=E829&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-26 N1 - Date created - 1989-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis. AN - 78553778; 3196365 AB - Twenty-six patients receiving long-term oral methotrexate (MTX) therapy for rheumatoid arthritis (24 patients) or psoriasis (2 patients) were prospectively evaluated for alterations in liver morphology by light microscopy, electron microscopy, and immunofluorescence microscopy. Although only 4 MTX-treated patients had light microscopic evidence of mild fibrosis, all had evidence of collagen deposition in the space of Disse near Ito cells and changes in hepatocyte lysosomes on electron microscopy. These findings were absent from control livers. Fibrinogen, fibronectin, and type IV collagen were identified by immunofluorescence in both MTX-treated patients and controls. We conclude that long-term MTX therapy for rheumatoid arthritis is associated with alterations in hepatic ultrastructure, including collagen deposition in the space of Disse and changes in hepatocyte lysosomes. JF - Arthritis and rheumatism AU - Bjorkman, D J AU - Hammond, E H AU - Lee, R G AU - Clegg, D O AU - Tolman, K G AD - Department of Internal Medicine, Veterans Administration Hospital, Salt Lake City, Utah. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1465 EP - 1472 VL - 31 IS - 12 SN - 0004-3591, 0004-3591 KW - Collagen KW - 9007-34-5 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Abridged Index Medicus KW - Index Medicus KW - Collagen -- metabolism KW - Humans KW - Aged KW - Liver Diseases -- metabolism KW - Microscopy, Fluorescence KW - Prospective Studies KW - Adult KW - Liver Diseases -- pathology KW - Microscopy KW - Middle Aged KW - Microscopy, Electron KW - Lysosomes -- drug effects KW - Female KW - Male KW - Liver -- ultrastructure KW - Arthritis, Rheumatoid -- drug therapy KW - Liver -- cytology KW - Methotrexate -- adverse effects KW - Chemical and Drug Induced Liver Injury KW - Methotrexate -- therapeutic use KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78553778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Hepatic+ultrastructure+after+methotrexate+therapy+for+rheumatoid+arthritis.&rft.au=Bjorkman%2C+D+J%3BHammond%2C+E+H%3BLee%2C+R+G%3BClegg%2C+D+O%3BTolman%2C+K+G&rft.aulast=Bjorkman&rft.aufirst=D&rft.date=1988-12-01&rft.volume=31&rft.issue=12&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-10 N1 - Date created - 1989-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anaphylaxis from rectal lubricant jelly. AN - 78549702; 3195616 JF - The American journal of medicine AU - Jones, S A AD - Veterans Administration Medical Center, Des Moines, Iowa 50310. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 890 VL - 85 IS - 6 SN - 0002-9343, 0002-9343 KW - Gels KW - 0 KW - Parabens KW - Barium Sulfate KW - 25BB7EKE2E KW - methylparaben KW - A2I8C7HI9T KW - Abridged Index Medicus KW - Index Medicus KW - Rectum KW - Humans KW - Adult KW - Male KW - Anaphylaxis -- chemically induced KW - Parabens -- adverse effects KW - Enema -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78549702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Anaphylaxis+from+rectal+lubricant+jelly.&rft.au=Jones%2C+S+A&rft.aulast=Jones&rft.aufirst=S&rft.date=1988-12-01&rft.volume=85&rft.issue=6&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-12 N1 - Date created - 1989-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Follicle-stimulating hormone is required for quantitatively normal inhibin secretion in men. AN - 78544684; 3142919 AB - Inhibin is a glycoprotein hormone produced by the testis and ovary which is postulated to be an important regulator of pituitary FSH secretion. Animal data indicate that inhibin is produced by the Sertoli cells of the testis under the influence of FSH. To determine the role of FSH withdrawal and replacement in the control of inhibin secretion in man, we measured serum inhibin concentrations in men in whom isolated FSH deficiency had been produced by chronic hCG administration; this was followed by FSH replacement. After a 3-month control period, four normal men received hCG for 7 months, resulting in suppression of serum FSH to undetectable levels and urinary FSH excretion to prepubertal levels. Their mean serum inhibin levels fell to 70% of control values during hCG administration [362 +/- 60 (+/- SE) vs. 518 +/- 56 U/L; P less than 0.01]. While continuing hCG, testosterone enanthate was administered for a further 6 months. Serum FSH and inhibin levels remained suppressed to a similar degree. Testosterone administration then was ceased, and hCG continued for a further 2-4 months. Then, while continuing hCG administration, FSH was replaced as either highly purified human FSH (n = 2) or human menopausal gonadotropin (n = 2) for a period of 4-10 months. Serum FSH levels increased to the mid- and upper normal male ranges, respectively. FSH replacement restored serum inhibin levels to 522 +/- 56 U/L (P = NS vs. control). In summary, prolonged selective FSH deficiency induced by chronic hCG administration suppressed inhibin secretion. Replacement of FSH activity restored inhibin secretion to control values. We conclude that 1) FSH is not absolutely required for inhibin secretion in men; and 2) the maintenance of quantitatively normal inhibin secretion requires the combined action of both gonadotropins. JF - The Journal of clinical endocrinology and metabolism AU - McLachlan, R I AU - Matsumoto, A M AU - Burger, H G AU - de Kretser, D M AU - Bremner, W J AD - Gerontology Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 1305 EP - 1308 VL - 67 IS - 6 SN - 0021-972X, 0021-972X KW - Chorionic Gonadotropin KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Inhibins KW - 57285-09-3 KW - testosterone enanthate KW - 7Z6522T8N9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Abridged Index Medicus KW - Index Medicus KW - Testosterone -- analogs & derivatives KW - Sperm Count -- drug effects KW - Drug Interactions KW - Testosterone -- pharmacology KW - Chorionic Gonadotropin -- pharmacology KW - Humans KW - Adult KW - Male KW - Follicle Stimulating Hormone -- deficiency KW - Follicle Stimulating Hormone -- physiology KW - Inhibins -- blood KW - Follicle Stimulating Hormone -- pharmacology KW - Inhibins -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78544684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Follicle-stimulating+hormone+is+required+for+quantitatively+normal+inhibin+secretion+in+men.&rft.au=McLachlan%2C+R+I%3BMatsumoto%2C+A+M%3BBurger%2C+H+G%3Bde+Kretser%2C+D+M%3BBremner%2C+W+J&rft.aulast=McLachlan&rft.aufirst=R&rft.date=1988-12-01&rft.volume=67&rft.issue=6&rft.spage=1305&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-03 N1 - Date created - 1989-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Common mistakes in managing metabolic disorders. AN - 78513566; 3186562 AB - Three mistakes are commonly made in managing metabolic disorders. 1. Oral fluids may be pushed to treat simple volume depletion. However, almost all fluids used for this purpose are sodium-poor and do not restore salt and water balance. 2. The physician may not be aware of common causes of hypophosphatemia, such as hyperventilation, sepsis, stress, use of antacids or diuretics, and alcoholism. If the patient is not monitored adequately, severe hypophosphatemia may develop with serious consequences. 3. Low serum bicarbonate levels may be attributed to metabolic acidosis only, when in actuality metabolic acidosis may coexist with respiratory alkalosis. Arterial blood gas studies differentiate the conditions and direct attention to the cause of respiratory alkalosis when present. JF - Postgraduate medicine AU - Elms, J J AD - Nephrology Section, Veterans Administration Medical Center, Augusta. Y1 - 1988/11/15/ PY - 1988 DA - 1988 Nov 15 SP - 115 EP - 6, 121-2 VL - 84 IS - 7 SN - 0032-5481, 0032-5481 KW - Bicarbonates KW - 0 KW - Phosphates KW - Sodium Chloride KW - 451W47IQ8X KW - Abridged Index Medicus KW - Index Medicus KW - Water-Electrolyte Imbalance -- diagnosis KW - Phosphates -- blood KW - Alcoholism -- therapy KW - Humans KW - Sodium Chloride -- administration & dosage KW - Aged KW - Kidney Failure, Chronic -- therapy KW - Monitoring, Physiologic KW - Bicarbonates -- blood KW - Alkalosis, Respiratory -- diagnosis KW - Fluid Therapy KW - Nutrition Disorders -- therapy KW - Female KW - Male KW - Metabolic Diseases -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78513566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Common+mistakes+in+managing+metabolic+disorders.&rft.au=Elms%2C+J+J&rft.aulast=Elms&rft.aufirst=J&rft.date=1988-11-15&rft.volume=84&rft.issue=7&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-19 N1 - Date created - 1988-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation inactivation analysis of oligomeric structure of the H,K-ATPase. AN - 78496926; 2846537 AB - The oligomeric size of the H,K-ATPase was determined in frozen gastric microsomal vesicles irradiated with high energy electrons. Target sizes of various catalytic activities associated with H,K-ATPase function fell into two distinct groups. The lower group of target sizes described the radiation-induced loss of steady-state phosphoenzyme and structural monomer: the MgATP-dependent formation of a beta-aspartyl phosphate exhibited a size range of 133-147 kDa; the size range for the structural measurement (i.e. loss of H,K-ATPase monomer on sodium dodecyl sulfate-polyacrylamide gels) was 92-143 kDa. In contrast, a larger group of target sizes described the loss of full cycle catalytic activities (i.e. K+-dependent stimulation of p-nitrophenyl phosphate and ATP hydrolysis). The K+-phosphatase and K+-stimulated ATPase exhibited target sizes fo 200 +/- 13 and 232 +/- 23 kDa, respectively. The lower target size group represents the first evidence that a monomer of the catalytic subunit maintains partial enzyme function. The larger group of target sizes describing K+-phosphatase and ATPase activities suggest that subunit interactions contribute to full cycle catalytic activity. Subunit interactions appear to be involved in all ion transport activities. Passive Rb+ exchange and active H+ transport in reconstituted proteoliposomes exhibited target sizes of 233n = 2 and 388 +/- 48 kDa, respectively. H+ transport appears to require a subunit arrangement more complex than that associated with catalytic activity or passive ion transport. JF - The Journal of biological chemistry AU - Rabon, E C AU - Gunther, R D AU - Bassilian, S AU - Kempner, E S AD - Center for Ulcer Research and Education, Veterans Administration Center, Wadsworth Division, Los Angeles, California 90073. Y1 - 1988/11/05/ PY - 1988 DA - 1988 Nov 05 SP - 16189 EP - 16194 VL - 263 IS - 31 SN - 0021-9258, 0021-9258 KW - Macromolecular Substances KW - 0 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Index Medicus KW - Swine KW - Animals KW - Kinetics KW - Microsomes -- enzymology KW - Dose-Response Relationship, Radiation KW - Stomach -- enzymology KW - Molecular Weight KW - Adenosine Triphosphatases -- radiation effects KW - Adenosine Triphosphatases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78496926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Radiation+inactivation+analysis+of+oligomeric+structure+of+the+H%2CK-ATPase.&rft.au=Rabon%2C+E+C%3BGunther%2C+R+D%3BBassilian%2C+S%3BKempner%2C+E+S&rft.aulast=Rabon&rft.aufirst=E&rft.date=1988-11-05&rft.volume=263&rft.issue=31&rft.spage=16189&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-02 N1 - Date created - 1988-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective Impairment of Phonation: A Case Study AN - 85502977; 8901935 AB - A case history of a 47-year-old M with left hemisphere damage who exhibited symptoms of Broca's aphasia with accompanying apraxia of speech. However, medical & other data indicated that Broca's aphasia was not a correct diagnosis. It was found that by providing the patient with an electrolarynx, the patient was enabled to communicate normally, suggesting a diagnosis of laryngeal apraxia. It is suggested that there may be distinct types of apraxia of speech associated with lesions in specific areas of the frontal motor association area of the brain. 4 Tables, 12 Figures, 37 References. B. Annesser Murray JF - Brain and Language AU - Marshall, Robert C AU - Gandour, Jack AU - Windsor, Jennifer AD - Audiology & Speech Pathology Service Veterans Administration Medical Center, Portland OR 97207 Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 313 EP - 339 VL - 35 IS - 2 SN - 0093-934X, 0093-934X KW - speech apraxia, electrolarynx use KW - Broca's aphasia misdiagnosis KW - case study KW - 47-year-old left hemisphere damaged male KW - Speech Therapy (sp13) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85502977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Selective+Impairment+of+Phonation%3A+A+Case+Study&rft.au=Marshall%2C+Robert+C%3BGandour%2C+Jack%3BWindsor%2C+Jennifer&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1988-11-01&rft.volume=35&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Speech Therapy (sp13) ER - TY - JOUR T1 - Validity of the Luria-Nebraska language scales in aphasia. AN - 85244504; pmid-3215735 AB - The language scales of the Luria-Nebraska Neuropsychological Battery (LNNB) were administered to patients classified as either Broca's (n = 7) or Wernicke's (n = 7) aphasics. Group comparisons were made on the standard scales (e.g., Receptive Speech, Expressive Speech, Reading & Writing) and on 13 factor-analytically derived subscales (McKay & Golden, 1981). Results indicated that the standard T-score profile failed to discriminate the distinctively different language syndromes. Only two of the 13 factor scales differentiated the groups. Although Wernicke's patients were more impaired than Broca's patients on factor-analytically derived measures of basic language comprehension, it was concluded that the subscales added little to the standard profile in terms of aphasia syndrome identification. Distinctively different profiles of impaired and retained language abilities did not emerge on the LNNB factor scales. The battery cannot be recommended for use with aphasic patients. JF - The International Journal of Neuroscience AU - Ryan, J J AU - Farage, C M AU - Mittenberg, W AU - Kasprisin, A AD - Leavenworth Veterans Administration Medical Center, Kansas 66048. PY - 1988 SP - 75 EP - 80 VL - 43 IS - 1-2 SN - 0020-7454, 0020-7454 KW - Aphasia, Wernicke KW - Aphasia KW - Aphasia, Broca KW - Human KW - Aged KW - Male KW - Language Tests KW - Luria-Nebraska Neuropsychological Battery KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+Neuroscience&rft.atitle=Validity+of+the+Luria-Nebraska+language+scales+in+aphasia.&rft.au=Ryan%2C+J+J%3BFarage%2C+C+M%3BMittenberg%2C+W%3BKasprisin%2C+A&rft.aulast=Ryan&rft.aufirst=J&rft.date=1988-11-01&rft.volume=43&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+Neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review. AN - 85223947; pmid-3055946 AB - Neoplasms arising in Meckel's diverticulum or involving hernia sacs are rare. The authors present a unique case of two asymptomatic carcinoid tumors arising in a Meckel's diverticulum, which were discovered because of microscopic metastasis in a grossly unremarkable inguinal hernia sac. This article describes the clinical and morphologic features of this unusual case, reviews the topic of neoplasms involving hernia sacs and Meckel's diverticula, and includes a brief review of immunocytochemical findings in carcinoid tumors. JF - The American Journal of Gastroenterology AU - Dixon, A Y AU - McAnaw, M AU - McGregor, D H AU - Keushkerian, S AU - Miller, L K AU - Pierce, P D AD - Laboratory Service, Veterans Administration Medical Center, Kansas City, Missouri. PY - 1988 SP - 1283 EP - 1288 VL - 83 IS - 11 SN - 0002-9270, 0002-9270 KW - Ileal Neoplasms KW - Human KW - Aged KW - Carcinoid Tumor KW - Case Report KW - Microscopy, Electron KW - Male KW - Neoplasms, Multiple Primary KW - Meckel's Diverticulum KW - Hernia, Inguinal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Dual+carcinoid+tumors+of+Meckel%27s+diverticulum+presenting+as+metastasis+in+an+inguinal+hernia+sac%3A+case+report+with+literature+review.&rft.au=Dixon%2C+A+Y%3BMcAnaw%2C+M%3BMcGregor%2C+D+H%3BKeushkerian%2C+S%3BMiller%2C+L+K%3BPierce%2C+P+D&rft.aulast=Dixon&rft.aufirst=A&rft.date=1988-11-01&rft.volume=83&rft.issue=11&rft.spage=1283&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prostaglandins in type II collagen-induced ear diseases. AN - 85208323; pmid-3232717 AB - This study examines the role of prostaglandins in type II collagen-induced inner ear disease. Hartley guinea pigs were immunized with type II collagen in complete Freund's adjuvant. Auditory brain stem response was measured initially and at 2, 3, 4, and 6 months after immunization. The presence of PGE2 and 6-keto-PGF1 alpha in the perilymph was determined by radioimmunoassay. Perilymph from immunized animals contained about five times more PGE2 and about three times more 6-keto-PGF1 alpha than the perilymph from control animals. However, the two groups showed no difference in the level of either PGE2 or 6-keto-PGF1 alpha in cerebrospinal fluid and serum. Immunized guinea pigs also showed evidence of hearing loss. The temporal bones showed the following changes: spiral ganglion degeneration; mild to moderate degeneration in the organ of Corti; and infrequent and very mild endolymphatic hydrops. Thus, prostaglandins might play an important role in the pathogenesis of type II collagen-induced inner ear disease. JF - The American Journal of Otology AU - Kitano, H AU - Takeda, T AU - Chiang, T M AU - Yoo, T J AD - Veterans Administration Medical Center, Department of Medicine, Memphis, TN. PY - 1988 SP - 465 EP - 469 VL - 9 IS - 6 SN - 0192-9763, 0192-9763 KW - Auditory Threshold KW - Guinea Pigs KW - Ear, Middle KW - Prostaglandins KW - Animal KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Perilymph KW - Ear Diseases KW - Female KW - Collagen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Otology&rft.atitle=Prostaglandins+in+type+II+collagen-induced+ear+diseases.&rft.au=Kitano%2C+H%3BTakeda%2C+T%3BChiang%2C+T+M%3BYoo%2C+T+J&rft.aulast=Kitano&rft.aufirst=H&rft.date=1988-11-01&rft.volume=9&rft.issue=6&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Otology&rft.issn=01929763&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mobilization of cadmium in mice by combined treatment with N-benzyl-N-dithiocarboxy-D-glucamine and diesters of meso-2, 3-dimercaptosuccinic acid. AN - 78757852; 2855182 AB - Mice which had received a non-lethal injection of cadmium (Cd) as CdCl2 nine days prior to therapy were treated with N-benzyl-N-dithiocarboxy-D-glucamine (BDCG) alone or in combination with either di(iso-butyl)dimercaptosuccinate (DiBDMS) or di(iso-amyl)-dimercaptosuccinate (DiADMS). Seven injections of BDCG (1.0 mmole/kg), DiBDMS (0.4 mmole/kg), and DiADMS (0.4 mmol/kg) reduced whole body Cd burdens 50%, 54% and 37%, respectively; coadministration of BDCG + DiBDMS and BDCG + DiADMS produced respective reductions of 65% and 61%. Seven injections of BDCG lowered renal Cd concentrations an average of 82%, but reduced hepatic Cd concentrations only 53%. The DMSA diesters were more effective in lowering hepatic Cd than in reducing the levels of Cd in the kidneys. The respective hepatic and renal Cd reductions were 50% and 20% after treatment with DiADMS, and were 73% and 30% after treatment with DiBDMS. Coadministration of BDCG with DiADMS reduced hepatic and renal Cd concentrations 74% and 82%, respectively, while BDCG co-administered with DiBDMS yielded respective reductions of 80% and 82%. It is suggested that combined use of these newer Cd complexing agents in studies of experimental Cd poisoning may now permit resolution of the issue of reversibility of Cd-induced nephrotoxicity. JF - Research communications in chemical pathology and pharmacology AU - Gale, G R AU - Atkins, L M AU - Smith, A B AU - Singh, P K AU - Jones, M M AD - Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 327 EP - 337 VL - 62 IS - 2 SN - 0034-5164, 0034-5164 KW - Chelating Agents KW - 0 KW - Sulfhydryl Compounds KW - Thiocarbamates KW - Cadmium KW - 00BH33GNGH KW - di-(isobutyl)dimercaptosuccinate KW - 118908-62-6 KW - di-(isoamyl)dimercaptosuccinate KW - 118908-63-7 KW - Sorbitol KW - 506T60A25R KW - Succimer KW - DX1U2629QE KW - N-benzylglucamine dithiocarbamate KW - M0OU990U9P KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Liver -- drug effects KW - Mice, Inbred C57BL KW - Kidney -- drug effects KW - Liver -- metabolism KW - Mice KW - Male KW - Mice, Inbred DBA KW - Chelating Agents -- pharmacology KW - Cadmium -- metabolism KW - Sulfhydryl Compounds -- pharmacology KW - Succimer -- analogs & derivatives KW - Sorbitol -- analogs & derivatives KW - Thiocarbamates -- pharmacology KW - Succimer -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78757852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Mobilization+of+cadmium+in+mice+by+combined+treatment+with+N-benzyl-N-dithiocarboxy-D-glucamine+and+diesters+of+meso-2%2C+3-dimercaptosuccinic+acid.&rft.au=Gale%2C+G+R%3BAtkins%2C+L+M%3BSmith%2C+A+B%3BSingh%2C+P+K%3BJones%2C+M+M&rft.aulast=Gale&rft.aufirst=G&rft.date=1988-11-01&rft.volume=62&rft.issue=2&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Septic arthritis and osteomyelitis from a cat bite. AN - 78734374; 3242317 AB - A 39-year-old man with no prior history of underlying arthritis developed osteomyelitis and septic arthritis in his hand following a cat bite. This case illustrates the virulence of Pasteurella multocida infections associated with animal bites, particularly those of cats, whose teeth can inoculate bone directly. The onset of cellulitis caused by P. multocida infections is often rapid, and the drug of choice for such infections remains penicillin. Appropriate antibiotic therapy, however, does not always prevent complications such as those seen in this patient. JF - The Yale journal of biology and medicine AU - Chodakewitz, J AU - Bia, F J AD - Department of Medicine, West Haven Veterans Administration Medical Center, Connecticut. PY - 1988 SP - 513 EP - 518 VL - 61 IS - 6 SN - 0044-0086, 0044-0086 KW - Penicillins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Pasteurella -- pathogenicity KW - Penicillins -- therapeutic use KW - Male KW - Arthritis, Infectious -- microbiology KW - Arthritis, Infectious -- drug therapy KW - Pasteurella Infections -- microbiology KW - Cats KW - Osteomyelitis -- drug therapy KW - Bites and Stings -- complications KW - Osteomyelitis -- microbiology KW - Hand Injuries -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78734374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Yale+journal+of+biology+and+medicine&rft.atitle=Septic+arthritis+and+osteomyelitis+from+a+cat+bite.&rft.au=Chodakewitz%2C+J%3BBia%2C+F+J&rft.aulast=Chodakewitz&rft.aufirst=J&rft.date=1988-11-01&rft.volume=61&rft.issue=6&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=The+Yale+journal+of+biology+and+medicine&rft.issn=00440086&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-15 N1 - Date created - 1989-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Conn Med. 1984 Apr;48(4):221-3 [6713856] J Clin Microbiol. 1978 Feb;7(2):223-31 [632349] Am J Public Health Nations Health. 1970 Jun;60(6):1109-17 [4915720] Am J Clin Pathol. 1969 Jun;51(6):705-8 [4976987] Ann Emerg Med. 1980 Feb;9(2):79-83 [7356213] J Trauma. 1980 May;20(5):383-9 [7365851] JAMA. 1983 Jan 28;249(4):508-9 [6848852] J Hand Surg Am. 1982 Jan;7(1):47-52 [7061808] South Med J. 1980 Oct;73(10):1349-52 [7434048] Pediatr Infect Dis J. 1987 Jan;6(1):8-10 [3547293] Medicine (Baltimore). 1984 May;63(3):133-54 [6371440] Pediatr Infect Dis J. 1987 Jan;6(1):29-32 [3822614] Rocky Mt Med J. 1968 Nov;65(11):45-6 [5749275] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal handling of 5-nitrofuran nephrotoxins in the rat. AN - 78717936; 2907461 AB - Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl)-hydrazide (FNT) and 3-hydroxymethyl-1-([3-(5-nitro-2-furyl)-allydidene]amino)hydantoin (HMN) were investigated to determine whether differences in the renal handling of these two chemicals might provide evidence to explain their different patterns of toxicity and carcinogenicity. The isolated perfused rat kidney and whole animal were used. In the isolated perfused rat kidney, both FNT and HMN had similar half-lives (t1/2) but the urinary excretion and renal clearance of HMN (2.1 +/- 0.4 greater than those of FNT (0.2 +/- 0.1 nmol/min and 0.06 +/- 0.01 ml/min, respectively). Probenecid increased the t1/2 and decreased the metabolic clearance of HMN but did not have any effect on FNT t1/2 or clearance. These differences in excretion of FNT and HMN could not be explained on the basis of protein binding. The total clearances of FNT and HMN were similar and significantly higher than that of the 5-nitrofuran bladder carcinogen ANFT. In the whole animal, the urinary excretion of HMN was about 10-fold greater than that of FNT. The t1/2 of both FNT and HMN was less than 5 min in the whole animal. Probenecid decreased the urinary excretion of HMN from 9.7 +/- 1.4% to 4.4 +/- 1.0% (p less than 0.05). Compared with HMN, FNT has less urinary excretion but a similar elimination t1/2, suggesting a greater nonrenal clearance. HMN but not FNT has tubular excretion. Thus, alterations in substituents of 5-nitrofurans markedly alter their renal handling and may partially explain their diverse toxic effects. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Ballal, S AU - Spry, L A AU - Zenser, T V AU - Davis, B B AD - Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Medical Center, St. Louis, MO 63125. PY - 1988 SP - 829 EP - 833 VL - 16 IS - 6 SN - 0090-9556, 0090-9556 KW - Hydantoins KW - 0 KW - Nitrofurans KW - nefurthiazole KW - 3570-75-0 KW - Inulin KW - 9005-80-5 KW - nifurmazole KW - LOF2A7032C KW - Probenecid KW - PO572Z7917 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - In Vitro Techniques KW - Probenecid -- pharmacology KW - Protein Binding KW - Male KW - Kidney Diseases -- metabolism KW - Kidney -- metabolism KW - Hydantoins -- metabolism KW - Nitrofurans -- toxicity KW - Nitrofurans -- metabolism KW - Hydantoins -- toxicity KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78717936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Renal+handling+of+5-nitrofuran+nephrotoxins+in+the+rat.&rft.au=Ballal%2C+S%3BSpry%2C+L+A%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Ballal&rft.aufirst=S&rft.date=1988-11-01&rft.volume=16&rft.issue=6&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute renal failure owing to inadvertent vancomycin overdose. Vancomycin removal by continuous arteriovenous hemofiltration. AN - 78715722; 3239947 AB - Acute renal failure developed in a patient who received 56 grams of vancomycin intravenously over a 10 day period. The resulting serum vancomycin level was 284 micrograms per ml and declined to 140 micrograms per ml in a linear fashion with the institution of continuous arteriovenous hemofiltration (CAVH). Our conclusion is that high blood vancomycin levels may be nephrotoxic and CAVH may be an effective means of vancomycin removal in patients with acute renal failure. JF - Annals of clinical and laboratory science AU - Walczyk, M H AU - Hill, D AU - Arai, A AU - Wolfson, M AD - Veterans Administration Medical Center, Portland, OR. PY - 1988 SP - 440 EP - 443 VL - 18 IS - 6 SN - 0091-7370, 0091-7370 KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Humans KW - Hemofiltration KW - Middle Aged KW - Male KW - Vancomycin -- poisoning KW - Acute Kidney Injury -- chemically induced KW - Acute Kidney Injury -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78715722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Acute+renal+failure+owing+to+inadvertent+vancomycin+overdose.+Vancomycin+removal+by+continuous+arteriovenous+hemofiltration.&rft.au=Walczyk%2C+M+H%3BHill%2C+D%3BArai%2C+A%3BWolfson%2C+M&rft.aulast=Walczyk&rft.aufirst=M&rft.date=1988-11-01&rft.volume=18&rft.issue=6&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beta-adrenoceptor antagonist-induced psoriasiform eruption. Clinical and pathogenetic aspects. AN - 78696427; 2906634 AB - A number of beta-adrenoceptor blocking drugs have been reported to induce a papulosquamous eruption which resembles psoriasis. We report distinctive clinical, histopathologic, immunocytochemical, and electron microscopic features in beta-blocker-induced psoriasiform eruptions that differentiate this syndrome from psoriasis. Preliminary data suggest that biopsy specimens from eruptions caused by beta 1-selective adrenoceptor blocking agents (metoprolol and atenolol) were characterized by excessive degranulation of the neutrophils in the dermis, while the nonselective beta blockers (propranolol, nadolol, and sotalol) were marked by excessive release of proteolytic enzymes from macrophages, which are thought to possess beta 2-adrenergic receptors. Surprisingly, excessive release of enzymes by lymphocytes were noted in both the beta 1-selective and in the nonselective induced syndromes. It is believed that excessive lysosomal enzyme release by neutrophils, lymphocytes, and macrophages is responsible for the presence of basal keratinocyte herniations, which have previously been shown to correlate with hyperproliferation and psoriasiform changes, as well as with the presence of excessive proteolytic enzymes in the skin. It is postulated that the beta-blocker-induced syndrome may result from enhanced proliferation, motility, and activity of lymphocytes, neutrophils, and cells of the macrophage-Langerhans cell series, stemming from depressed intracellular cyclic adenosine monophosphate levels caused by the beta blockade. JF - International journal of dermatology AU - Heng, M C AU - Heng, M K AD - Department of Medicine, Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 619 EP - 627 VL - 27 IS - 9 SN - 0011-9059, 0011-9059 KW - Adrenergic beta-Antagonists KW - 0 KW - Index Medicus KW - Psoriasis -- pathology KW - Humans KW - Psoriasis -- diagnosis KW - Aged KW - Middle Aged KW - Biopsy KW - Fluorescent Antibody Technique KW - Male KW - Female KW - Adrenergic beta-Antagonists -- adverse effects KW - Drug Eruptions -- pathology KW - Drug Eruptions -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78696427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+dermatology&rft.atitle=Beta-adrenoceptor+antagonist-induced+psoriasiform+eruption.+Clinical+and+pathogenetic+aspects.&rft.au=Heng%2C+M+C%3BHeng%2C+M+K&rft.aulast=Heng&rft.aufirst=M&rft.date=1988-11-01&rft.volume=27&rft.issue=9&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=International+journal+of+dermatology&rft.issn=00119059&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-12 N1 - Date created - 1989-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Propranolol in the treatment of neuroleptic-induced akathisia (NIA) in schizophrenics: a double-blind, placebo-controlled study. AN - 78675702; 2906547 JF - Biological psychiatry AU - Kramer, M S AU - Gorkin, R A AU - DiJohnson, C AU - Sheves, P AD - Coatesville Veterans Administration Medical Center, PA 19320. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 823 EP - 827 VL - 24 IS - 7 SN - 0006-3223, 0006-3223 KW - Antipsychotic Agents KW - 0 KW - Propranolol KW - 9Y8NXQ24VQ KW - Index Medicus KW - Psychomotor Agitation -- drug therapy KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Arousal -- drug effects KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Propranolol -- therapeutic use KW - Akathisia, Drug-Induced KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78675702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Propranolol+in+the+treatment+of+neuroleptic-induced+akathisia+%28NIA%29+in+schizophrenics%3A+a+double-blind%2C+placebo-controlled+study.&rft.au=Kramer%2C+M+S%3BGorkin%2C+R+A%3BDiJohnson%2C+C%3BSheves%2C+P&rft.aulast=Kramer&rft.aufirst=M&rft.date=1988-11-01&rft.volume=24&rft.issue=7&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mental illness complicated by the santeria belief in spirit possession. AN - 78664283; 3224955 AB - Santeria, a religious system that blends African and Catholic beliefs, is practiced by many Cuban Americans. One aspect of this system is the belief in spirit possession. Basic santeria beliefs and rituals, including the fiesta santera (a gathering at which some participants may become possessed), are briefly described, and four cases in which the patients' belief in possession played a role in their mental illness are presented. The belief in possession can complicate the diagnosis and treatment of mental illness, but it should not be considered a culture-bound syndrome. Rather, it may be a nonspecific symptom of a variety of mental illnesses and should be evaluated in the context of the patient's overall belief system and ability to carry out usual activities. JF - Hospital & community psychiatry AU - Alonso, L AU - Jeffrey, W D AD - Geriatric Neuropsychiatry Unit, St. Albans Veterans Administration Extended Care Center-Veterans Administration Medical Center, Brooklyn, New York. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1188 EP - 1191 VL - 39 IS - 11 SN - 0022-1597, 0022-1597 KW - Index Medicus KW - United States KW - Hallucinations -- psychology KW - Cuba -- ethnology KW - Humans KW - Adult KW - Bipolar Disorder -- psychology KW - Aged KW - Middle Aged KW - Shared Paranoid Disorder -- psychology KW - Alcoholism -- psychology KW - Female KW - Religion and Psychology KW - Magic KW - Mental Disorders -- psychology KW - Hispanic Americans -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78664283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hospital+%26+community+psychiatry&rft.atitle=Mental+illness+complicated+by+the+santeria+belief+in+spirit+possession.&rft.au=Alonso%2C+L%3BJeffrey%2C+W+D&rft.aulast=Alonso&rft.aufirst=L&rft.date=1988-11-01&rft.volume=39&rft.issue=11&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Hospital+%26+community+psychiatry&rft.issn=00221597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-06 N1 - Date created - 1989-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth. AN - 78663560; 2851972 AB - We studied the effect of growth on beta-adrenergic receptor properties of neonatal rat heart myocytes cultured in serum-free medium with transferrin and insulin. Growth was induced by addition of 1 microM (-)-norepinephrine for two days, 200 nM of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) for two days, or 30 nM T3 for six days. The Kd values for beta-receptor binding (125I-ICYP) were unaffected by growth. The maximum number of beta-receptor binding sites calculated as sites/cell was increased 1.47-fold by T3 (p less than .005), but was decreased to 54% of control values by (-)-norepinephrine (p less than .005): TPA had no effect on either Kd or Bmax values. (-)-Isoproterenol-stimulated adenylate cyclase activity was augmented only in membranes from T3-treated cells and was reduced by 69% in membranes from (-)-norepinephrine treated cells. TPA had no effect on (-)-isoproterenol-stimulated adenylate cyclase activity. We conclude that the mechanisms controlling beta-adrenergic receptor number may be distinct from those controlling growth, since receptor number does not correlate with cell enlargement. Furthermore, in (-)-norepinephrine-stimulated growth, which we have shown previously is an alpha 1-adrenoceptor mediated response, beta-adrenergic signal transduction is modulated in a directionally opposite fashion. JF - Basic research in cardiology AU - Karliner, J S AU - Simpson, P C AD - Cardiology Service, Veterans Administration Medical Center, San Francisco. PY - 1988 SP - 655 EP - 663 VL - 83 IS - 6 SN - 0300-8428, 0300-8428 KW - Receptors, Adrenergic, beta KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Triiodothyronine -- pharmacology KW - Norepinephrine -- pharmacology KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Radioligand Assay KW - Myocardium -- cytology KW - Receptors, Adrenergic, beta -- physiology KW - Cell Differentiation -- drug effects KW - Adenylyl Cyclases -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78663560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+research+in+cardiology&rft.atitle=Beta-adrenoceptor+and+adenylate+cyclase+regulation+in+cardiac+myocyte+growth.&rft.au=Karliner%2C+J+S%3BSimpson%2C+P+C&rft.aulast=Karliner&rft.aufirst=J&rft.date=1988-11-01&rft.volume=83&rft.issue=6&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=Basic+research+in+cardiology&rft.issn=03008428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - What happens to patients after upper and lower gastrointestinal tract barium studies? AN - 78608562; 3061971 AB - We investigated the occurrence of new constipation, diarrhea, nausea, vomiting, visible blood in stool, abdominal pain, black stools, belching, and flatus in 324 outpatients following upper or lower gastrointestinal tract barium procedures. We also evaluated the roles of age, sex, patient mobility, and types of barium enema (single- or double-contrast). At least one new symptom was reported after 51% of all examinations. Constipation was the most frequently reported single symptom after barium meal or small bowel examinations. Fifty percent of all constipation occurred following upper gastrointestinal examinations. Abdominal pain was common in patients of the seventh decade, especially following barium enema. Nausea typically followed barium swallow or upper gastrointestinal series. Belching and passage of flatus were the most frequently reported symptoms after barium enema, both single- and double-contrast. No significant relationship between the frequency of symptoms and patient age, sex, or the type of barium enema was established. JF - Investigative radiology AU - Smith, H J AU - Jones, K AU - Hunter, T B AD - Radiology Service, Dallas Veterans Administration Medical Center, TX 75216. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 822 EP - 826 VL - 23 IS - 11 SN - 0020-9996, 0020-9996 KW - Barium Sulfate KW - 25BB7EKE2E KW - Index Medicus KW - Multicenter Studies as Topic KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Radiography KW - Male KW - Female KW - Gastrointestinal Diseases -- etiology KW - Gastrointestinal Diseases -- diagnostic imaging KW - Barium Sulfate -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78608562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=What+happens+to+patients+after+upper+and+lower+gastrointestinal+tract+barium+studies%3F&rft.au=Smith%2C+H+J%3BJones%2C+K%3BHunter%2C+T+B&rft.aulast=Smith&rft.aufirst=H&rft.date=1988-11-01&rft.volume=23&rft.issue=11&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-15 N1 - Date created - 1989-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - PMA-induced pulmonary edema: mechanisms of the vasoactive response. AN - 78593909; 3145281 AB - We investigated the effect of phorbol myristate acetate (PMA) in isolated guinea pig lungs perfused with phosphate-buffered Ringer solution. Pulmonary arterial pressure (Ppa), pulmonary capillary pressure (Ppc), and change in lung weight were recorded at 0, 10, 25, 40, and 70 min. The capillary filtration coefficient (Kf), an index of vascular permeability, was measured at 10 and 70 min. The perfusion of PMA (0.5 x 10(-7) M) increased Ppa, Ppc, and lung weight at 70 min. The ratio of arterial-to-venous vascular resistance (Ra/Rv) decreased and the Kf did not change with PMA. The perfusion of the lung with 4 alpha-phorbol didecanoate (inactive toward the protein kinase C analogue of PMA) did not affect the lung. The inhibition of TxA2 synthase with dazoxiben inhibited the response to PMA. The inhibition of the 5-lipoxygenase with U-60257 and the SRS-A receptor antagonist FPL 55712 also prevented the response to PMA. The addition of superoxide dismutase (SOD), catalase, or SOD plus catalase (the enzymes that remove O.2 H2O2, and OH., respectively) did not prevent the PMA effect or the release of TxA2; however, dimethylthiourea (DMTU), a scavenger of OH., did prevent the response to PMA. The data indicate that PMA causes a neutrophil-independent increase in lung weight due to increases in Ppc mediated by TxA2 and SRS-A. The protective effect of DMTU may be due to the inhibition of TxA2 generation. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Johnson, A AD - Research Service, Veterans Administration Medical Center, Albany, New York. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 2302 EP - 2312 VL - 65 IS - 5 SN - 8750-7587, 8750-7587 KW - SRS-A KW - 0 KW - Thromboxane A2 KW - 57576-52-0 KW - 1,3-dimethylthiourea KW - 8P30PMD17W KW - Papaverine KW - DAA13NKG2Q KW - Thiourea KW - GYV9AM2QAG KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Perfusion KW - Guinea Pigs KW - Thiourea -- pharmacology KW - Vascular Resistance -- drug effects KW - Capillary Permeability -- drug effects KW - Blood Pressure -- drug effects KW - Thiourea -- analogs & derivatives KW - Male KW - Female KW - Papaverine -- pharmacology KW - Tetradecanoylphorbol Acetate -- toxicity KW - Thromboxane A2 -- biosynthesis KW - Pulmonary Edema -- chemically induced KW - Pulmonary Edema -- physiopathology KW - SRS-A -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78593909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=PMA-induced+pulmonary+edema%3A+mechanisms+of+the+vasoactive+response.&rft.au=Johnson%2C+A&rft.aulast=Johnson&rft.aufirst=A&rft.date=1988-11-01&rft.volume=65&rft.issue=5&rft.spage=2302&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of phospholipase A2 and its hydrolytic products on alveolar epithelial permeability and elastase-induced emphysema. AN - 78585289; 3264481 AB - To cause emphysema, proteases that are instilled into the air spaces must first be transported across the alveolar epithelium, a barrier that is normally quite impermeable to macromolecules. It was postulated that phospholipase A2 (PLA2) exposure would potentiate porcine pancreatic elastase (PPE)-induced epithelial solute permeability in a manner similar to that which was previously shown with lysophosphatidylcholine (lysoPC), a naturally occurring, membrane-perturbing agent that is formed principally through the hydrolysis of phosphatidylcholine by PLA2. Groups of hamsters were given intratracheal injections of PLA2 (0.3 units) or one of the expected hydrolytic products of PLA2 in equimolar concentrations, lysoPC (135 micrograms), arachidonic acid (AA) (100 micrograms), or palmitic acid (PA) (70 micrograms) with or without PPE (4 units). Epithelial permeability surface area products (PS) of the alveolar epithelium to [14C]sucrose and 125I-labeled neutral dextran (MW, 70,000) were measured in isolated perfused lungs 30 min after instillation, and emphysema severity was assessed at 3 wk by pressure-volume relationships and by mean linear intercepts. Additionally, the effects of lysoPC, PA, and AA on the functions of PPE and alpha 1-antiprotease (alpha 1 PI) in vitro were evaluated. Sucrose and dextran 70 PS differed significantly from controls only in those groups of hamsters that received PLA2 of lysoPC (p less than 0.05). LysoPC and PLA2 also potentiated the severity of PPE-induced emphysema to a similar degree (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Rice, K L AU - Duane, P G AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1196 EP - 1200 VL - 138 IS - 5 SN - 0003-0805, 0003-0805 KW - Blood Proteins KW - 0 KW - Lysophosphatidylcholines KW - alpha 1-Antitrypsin KW - Elastin KW - 9007-58-3 KW - Phospholipases KW - EC 3.1.- KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Elastin -- pharmacology KW - Pancreatic Elastase -- pharmacology KW - Drug Interactions KW - Blood Proteins -- pharmacology KW - Hydrolysis KW - Epithelium -- drug effects KW - Permeability KW - Lysophosphatidylcholines -- pharmacology KW - Mesocricetus KW - Epithelium -- metabolism KW - Female KW - Cricetinae KW - Phospholipases A -- pharmacology KW - Phospholipases -- pharmacology KW - Pulmonary Alveoli -- metabolism KW - Pulmonary Alveoli -- drug effects KW - Emphysema -- physiopathology KW - Emphysema -- chemically induced KW - Phospholipases A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78585289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Effects+of+phospholipase+A2+and+its+hydrolytic+products+on+alveolar+epithelial+permeability+and+elastase-induced+emphysema.&rft.au=Rice%2C+K+L%3BDuane%2C+P+G%3BNiewoehner%2C+D+E&rft.aulast=Rice&rft.aufirst=K&rft.date=1988-11-01&rft.volume=138&rft.issue=5&rft.spage=1196&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-24 N1 - Date created - 1989-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Legionnaires' disease in the work environment: implications for environmental health. AN - 78553488; 3195473 AB - Legionnaires' disease is a severe pneumonia caused by the bacterium Legionella pneumophila. Outbreaks of Legionnaire's disease have occurred in hotels, hospitals, and homes but had not been reported yet in the work environment. The authors report the occurrence of Legionnaires' disease in three employees of two industrial plants. The potable water in the two plants contained high numbers of Legionella pneumophila. Monoclonal antibody subtyping of environmental and patient isolates of L. pneumophila implicated one of the plants as the source for the disease. L. pneumophila was eradicated from this plant using acidic and caustic scale removers, calcium hypochlorite, and a biocide. A systematic approach to Legionnaires' disease in the work environment, a problem which can be expected to be recognized with increasing frequency, is presented. JF - American Industrial Hygiene Association journal AU - Muraca, P W AU - Stout, J E AU - Yu, V L AU - Yee, Y C AD - Special Pathogens Section, Veterans Administration Medical Center, Pittsburgh, PA. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 584 EP - 590 VL - 49 IS - 11 SN - 0002-8894, 0002-8894 KW - Antibodies, Monoclonal KW - 0 KW - Index Medicus KW - Legionella -- isolation & purification KW - Disinfection -- methods KW - Serologic Tests KW - Humans KW - Middle Aged KW - Water Microbiology KW - Male KW - Female KW - Legionnaires' Disease -- prevention & control KW - Legionnaires' Disease -- epidemiology KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78553488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Legionnaires%27+disease+in+the+work+environment%3A+implications+for+environmental+health.&rft.au=Muraca%2C+P+W%3BStout%2C+J+E%3BYu%2C+V+L%3BYee%2C+Y+C&rft.aulast=Muraca&rft.aufirst=P&rft.date=1988-11-01&rft.volume=49&rft.issue=11&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-12 N1 - Date created - 1989-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A clinical survey of aortobifemoral bypass using two inherently different graft types. AN - 78525133; 2973287 AB - The performance of knitted Dacron and polytetrafluoroethylene (PTFE) bifurcated grafts are compared in this study of 312 patients at a single institution. Patients of the two graft groups were statistically well-matched in risk factors and degree of distal obstructive disease. Operating time needed to implant either graft was approximately equal. For patients with abdominal aortic aneurysms, mean volume of blood transfused was 2.2 units for Dacron grafts and 0.2 units for PTFE grafts; for patients with aortoiliac occlusive disease, the comparable figures were 1.1 units and 0.1 units, respectively. Four-year cumulative patency for Dacron (90%) and PTFE (97%) grafts were not significantly different (p greater than 0.01). Complications affected 13% of the patients of the Dacron group and 4% of the PTFE group. All six graft infections and all seven graft double-limb thromboses occurred in Dacron grafts. Anastomotic aneurysms, amputations, and late graft revisions occurred with greater frequency in patients with Dacron grafts. JF - Annals of surgery AU - Cintora, I AU - Pearce, D E AU - Cannon, J A AD - Surgical Service, Carl Hayden Veterans Administration Medical Center, Phoenix, Arizona. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 625 EP - 630 VL - 208 IS - 5 SN - 0003-4932, 0003-4932 KW - Polyethylene Terephthalates KW - 0 KW - Polytetrafluoroethylene KW - 9002-84-0 KW - Abridged Index Medicus KW - Index Medicus KW - Thrombophlebitis -- surgery KW - Anastomosis, Surgical KW - Thrombophlebitis -- chemically induced KW - Amputation KW - Humans KW - Retrospective Studies KW - Aged KW - Evaluation Studies as Topic KW - Vascular Patency KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Femoral Artery -- surgery KW - Aorta -- surgery KW - Blood Vessel Prosthesis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78525133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgery&rft.atitle=A+clinical+survey+of+aortobifemoral+bypass+using+two+inherently+different+graft+types.&rft.au=Cintora%2C+I%3BPearce%2C+D+E%3BCannon%2C+J+A&rft.aulast=Cintora&rft.aufirst=I&rft.date=1988-11-01&rft.volume=208&rft.issue=5&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgery&rft.issn=00034932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-07 N1 - Date created - 1988-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 1977 Jan;35(1):1-39 [831755] Ann Surg. 1964 Oct;160:622-39 [14210364] Surgery. 1980 Nov;88(5):642-53 [7434204] Br J Surg. 1982 Jul;69(7):380-2 [6213283] Haemostasis. 1983;13(2):113-8 [6223864] J Cardiovasc Surg (Torino). 1984 Jan-Feb;25(1):36-42 [6231298] Arch Surg. 1985 Mar;120(3):289-95 [3882078] J Surg Res. 1985 Jun;38(6):648-55 [3159936] Am J Surg. 1985 Aug;150(2):185-90 [3161349] J Vasc Surg. 1986 Mar;3(3):421-36 [3951027] J Vasc Surg. 1986 May;3(5):732-40 [2939263] Biomaterials. 1986 Nov;7(6):441-8 [2947640] J Vasc Surg. 1987 Feb;5(2):311-8 [2950244] J Cardiovasc Surg (Torino). 1987 Jul-Aug;28(4):420-6 [2954987] Presse Med. 1951 Feb 21;59(12):234-6 [14816331] Surgery. 1978 Dec;84(6):739-48 [152480] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arginine vasopressin promotes growth of rat glomerular mesangial cells in culture. AN - 78525015; 2973244 AB - Arginine vasopressin (AVP) binds specifically to vascular smooth muscle-like mesangial cells (MCs) and affects contraction. We tested whether this peptide also modulates growth behavior of rat MCs in early subculture (passage 2-5). Subconfluent, serum-starved MCs were exposed to AVP (10(-10)-10(-6) M) in the presence or absence of insulin (5 micrograms/ml). To assess DNA replication, MC uptake of [3H]thymidine (24-h pulse) was determined on days 1, 2, and 3. AVP alone averaged a 1.97-fold increase in DNA synthesis at 24 h, whereas the mean stimulatory effects of AVP at 48 and 72 h were 7.21- and 5.42-fold, respectively. MCs exposed simultaneously to AVP and insulin showed potentiation of the mitogenic response to AVP alone. The V1-receptor antagonist [1-(beta-mercapto-beta,beta-cyclopentamethylene proprionic acid), 2-(O-methyl-Tyr)-Arg]vasopressin (PMP) inhibited only AVP-induced promotion of MC growth (maximal inhibition of -78.3%). The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) acutely stimulated MC proliferation but did not add to the AVP effect. Preincubation of MCs with 600 nM of TPA for 48 h significantly inhibited AVP-induced mitogenesis (-87.2%). By use of fura-2, intracellular calcium (Cai) was assessed by spectrofluorometry. The addition of AVP (10(-12)-10(-6) M) led to a rapid, transient, dose-dependent increase in Cai of 154-383%, respectively. The AVP-induced increase in Cai was greatly inhibited by 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester hydrochloride (TMB-8) (10(-8)-10(-6) M), an inhibitor of Cai release (-23.9 to -72.1%), and it was blunted by the atrial natriuretic peptide AP-28 (-38.3%).(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of physiology AU - Ganz, M B AU - Pekar, S K AU - Perfetto, M C AU - Sterzel, R B AD - Department of Medicine, West Haven Veterans Administration Medical Center, Yale University School of Medicine, New Haven, Connecticut 06516. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - F898 EP - F906 VL - 255 IS - 5 Pt 2 SN - 0002-9513, 0002-9513 KW - Benzofurans KW - 0 KW - Calcium Channel Blockers KW - Fluorescent Dyes KW - Insulin KW - Arginine Vasopressin KW - 113-79-1 KW - 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate KW - 57818-92-5 KW - Gallic Acid KW - 632XD903SP KW - vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- KW - 73168-24-8 KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - DNA KW - 9007-49-2 KW - Verapamil KW - CJ0O37KU29 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Fura-2 KW - TSN3DL106G KW - Index Medicus KW - Gallic Acid -- pharmacology KW - Animals KW - Spectrometry, Fluorescence KW - Atrial Natriuretic Factor -- pharmacology KW - Cell Division -- drug effects KW - Gallic Acid -- analogs & derivatives KW - Insulin -- pharmacology KW - Verapamil -- pharmacology KW - DNA -- biosynthesis KW - Rats KW - Calcium -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Drug Synergism KW - Male KW - Arginine Vasopressin -- pharmacology KW - Arginine Vasopressin -- analogs & derivatives KW - Glomerular Mesangium -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78525015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Arginine+vasopressin+promotes+growth+of+rat+glomerular+mesangial+cells+in+culture.&rft.au=Ganz%2C+M+B%3BPekar%2C+S+K%3BPerfetto%2C+M+C%3BSterzel%2C+R+B&rft.aulast=Ganz&rft.aufirst=M&rft.date=1988-11-01&rft.volume=255&rft.issue=5+Pt+2&rft.spage=F898&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-14 N1 - Date created - 1988-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dithiocarbamate treatment of chronic cadmium intoxication in mice. AN - 78520330; 3188085 AB - The dithiocarbamate analogs, N-benzyl-N-dithiocarboxy-D-glucamine (BDCG) and N-cyclohexyl-N-(2-hydroxy-3-sulfonatopropyl)dithiocarbamate (CAPSO-DTC), were evaluated as cadmium (Cd) antagonists in mice which had received repetitive injections of Cd to effect accumulation of substantial levels of metallothionein-bound Cd in kidneys and livers. BDCG was highly effective in lowering whole body Cd stores and renal Cd concentrations. While the percent of renal Cd mobilized decreased with increasing Cd concentrations, the total amount of Cd mobilized increased. CAPSO-DTC was also effective in reducing whole body Cd levels, but appeared to have less affinity for renal Cd than did BDCG. Treatment of Cd-laden mice with BDCG provoked only a modest elevation of serum creatinine levels, suggesting that the complex of Cd with BDCG may be less nephrotoxic than the complex of Cd with EDTA or dimercaprol. The log of the percent reduction of renal Cd by BDCG was found to be a linear function of the pretreatment renal Cd concentration, and reductions of whole body Cd burdens correlated closely with reductions of liver and kidney Cd concentrations. It was suggested that a Cd complexing agent of the dithiocarbamate class may have ultimate application in a provocative methodology to estimate body or organ Cd stores based upon the amount of Cd excreted following a standard dose of the chelator. JF - Toxicology letters AU - Gale, G R AU - Atkins, L M AU - Smith, A B AU - Jones, S G AU - Jones, M M AD - Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 77 EP - 84 VL - 44 IS - 1-2 SN - 0378-4274, 0378-4274 KW - Thiocarbamates KW - 0 KW - Cadmium KW - 00BH33GNGH KW - N-cyclohexyl-N-(2-hydroxy-3-sulfonatopropyl)dithiocarbamate KW - 112805-09-1 KW - Sorbitol KW - 506T60A25R KW - Creatinine KW - AYI8EX34EU KW - N-benzylglucamine dithiocarbamate KW - M0OU990U9P KW - Index Medicus KW - Cadmium -- metabolism KW - Animals KW - Kidney -- metabolism KW - Body Burden KW - Liver -- metabolism KW - Mice KW - Creatinine -- blood KW - Male KW - Cadmium Poisoning -- metabolism KW - Sorbitol -- analogs & derivatives KW - Cadmium Poisoning -- drug therapy KW - Thiocarbamates -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78520330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Dithiocarbamate+treatment+of+chronic+cadmium+intoxication+in+mice.&rft.au=Gale%2C+G+R%3BAtkins%2C+L+M%3BSmith%2C+A+B%3BJones%2C+S+G%3BJones%2C+M+M&rft.aulast=Gale&rft.aufirst=G&rft.date=1988-11-01&rft.volume=44&rft.issue=1-2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-16 N1 - Date created - 1988-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Food impaction and strictures after sclerotherapy of esophageal varices. AN - 78518843; 3263793 AB - Esophageal stricture is a common complication of endoscopic variceal sclerotherapy (EVS). The belief was that it could be managed safely and easily by esophageal dilation. Of 103 patients treated at our institution with EVS, 31 developed strictures, and of these, five have presented with food impaction (16.1%), a previously unreported complication. Three of the five had undergone prior esophageal dilation. Our patients received an average of 89 ml of 1.5% sodium tetradecyl in 7.6 sessions, compared with 51 ml in three sessions in an earlier group of EVS-induced strictures without food impaction. Esophageal manometric abnormalities were seen in three of four patients studied, two with markedly impaired peristaltic activity. All patients had successful treatment of both esophageal stricture and bleeding varices. Further sclerotherapy continued in four of five patients without additional problems. Food impaction in EVS-induced esophageal stricture can occur, despite dilation therapy. JF - The American journal of gastroenterology AU - Waring, J P AU - Sanowski, R A AD - Division of Gastroenterology, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1245 EP - 1247 VL - 83 IS - 11 SN - 0002-9270, 0002-9270 KW - Sclerosing Solutions KW - 0 KW - Index Medicus KW - Humans KW - Esophagogastric Junction -- physiopathology KW - Manometry KW - Esophageal and Gastric Varices -- therapy KW - Deglutition Disorders -- therapy KW - Catheterization KW - Sclerosing Solutions -- adverse effects KW - Esophageal Stenosis -- therapy KW - Esophageal Stenosis -- etiology KW - Gastrointestinal Hemorrhage -- therapy KW - Esophageal Stenosis -- physiopathology KW - Deglutition Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78518843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Food+impaction+and+strictures+after+sclerotherapy+of+esophageal+varices.&rft.au=Waring%2C+J+P%3BSanowski%2C+R+A&rft.aulast=Waring&rft.aufirst=J&rft.date=1988-11-01&rft.volume=83&rft.issue=11&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-05 N1 - Date created - 1988-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the hypothalamic-hypophysial, thyroid, and gonadal axes before and after disulfiram administration in patients with chronic alcoholism. AN - 78513798; 3055325 AB - We studied 14 alcoholic men without evidence of liver damage. After two weeks of alcohol abstinence, the patients were divided into two groups of seven patients each. Hypothalamic-hypophysial, thyroid, and gonadal axis tests were done on group 1 patients before disulfiram administration, and the tests were later repeated while the patients were taking disulfiram. Group 2 patients had initial testing done while taking disulfiram and repeat testing after the drug was stopped. The following abnormalities were found and were not affected by disulfiram: lack of suppression of both growth hormone and glucagon with oral glucose intake, and lack of response of follicle-stimulating hormone after administration of synthetic gonadotropin-releasing hormone. After disulfiram administration, we noticed a blunted response of thyrotropin to thyrotropin-releasing hormone. JF - Southern medical journal AU - Ramirez, G AU - Ables, M F AU - Butcher, D E AU - Morris, A D AD - Department of Internal Medicine, Tampa Veterans Administration Medical Center, FL. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1407 EP - 1411 VL - 81 IS - 11 SN - 0038-4348, 0038-4348 KW - Insulin KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Levodopa KW - 46627O600J KW - Glucagon KW - 9007-92-5 KW - Disulfiram KW - TR3MLJ1UAI KW - Abridged Index Medicus KW - Index Medicus KW - Glucose Tolerance Test KW - Random Allocation KW - Insulin -- blood KW - Humans KW - Testosterone -- blood KW - Adult KW - Thyroid Function Tests KW - Middle Aged KW - Glucagon -- blood KW - Radioimmunoassay KW - Male KW - Hypothalamo-Hypophyseal System -- drug effects KW - Disulfiram -- therapeutic use KW - Thyroid Gland -- drug effects KW - Testis -- drug effects KW - Disulfiram -- pharmacology KW - Alcoholism -- drug therapy KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78513798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Evaluation+of+the+hypothalamic-hypophysial%2C+thyroid%2C+and+gonadal+axes+before+and+after+disulfiram+administration+in+patients+with+chronic+alcoholism.&rft.au=Ramirez%2C+G%3BAbles%2C+M+F%3BButcher%2C+D+E%3BMorris%2C+A+D&rft.aulast=Ramirez&rft.aufirst=G&rft.date=1988-11-01&rft.volume=81&rft.issue=11&rft.spage=1407&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-09 N1 - Date created - 1988-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hepatic regenerative enzyme activity after diffuse injury with galactosamine: relationship to histologic alterations. AN - 78510658; 3183490 AB - Massive liver injury with 1000 mg/kg D-galactosamine was followed by a broad peak of thymidine kinase (TK) activity over 62 to 120 hours. The highest mean value was a 29-fold increase in activity. Three peaks of ornithine decarboxylase (ODC) activity were observed over the same time span. The first peak occurred at 45 hours, showing a sevenfold to eightfold increase in activity. Histologic evidence of necrosis peaked at 12 to 24 hours and was prominent over 54 hours. Periportal inflammation in response to the cellular injury was prominent from 12 to 96 hours and peaked at 45 to 62 hours. The curve of mitoses peaked at the same time as that of TK activity but was only 68% as extensive. The first peak of ODC activity occurred before there was any significant presence of mitoses or of TK activity. A smaller dose of 400 mg/kg resulted in a narrow peak of TK activity at 62 hours that was a 37-fold increase in activity. The total TK response was 43% of that seen after the larger dose, about in proportion to the dose given. The first ODC peak, representing the earliest evidence of regeneration, was earlier and more prominent after the 400 mg/kg dose. On the basis of areas under the curves, the amounts of necrosis and of periportal inflammation after 400 mg/kg were 36% of those seen after 1000 mg/kg. Corresponding figures for other response curves were 29% for mitoses, 33% for serum SGPT, and 71% for total ODC activity.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of laboratory and clinical medicine AU - Zieve, L AU - Anderson, W R AU - Dozeman, R AD - Veterans Administration, Medical Center, Minneapolis, MN. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 575 EP - 582 VL - 112 IS - 5 SN - 0022-2143, 0022-2143 KW - Galactosamine KW - 7535-00-4 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Alanine Transaminase -- blood KW - Male KW - Liver -- pathology KW - Liver -- enzymology KW - Galactosamine -- toxicity KW - Liver -- drug effects KW - Thymidine Kinase -- analysis KW - Ornithine Decarboxylase -- analysis KW - Liver Regeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78510658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Hepatic+regenerative+enzyme+activity+after+diffuse+injury+with+galactosamine%3A+relationship+to+histologic+alterations.&rft.au=Zieve%2C+L%3BAnderson%2C+W+R%3BDozeman%2C+R&rft.aulast=Zieve&rft.aufirst=L&rft.date=1988-11-01&rft.volume=112&rft.issue=5&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-12 N1 - Date created - 1988-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Korsakoff's syndrome: radiological (CT) findings and neuropsychological correlates. AN - 78505754; 3183726 AB - Quantitative analyses were performed on computer tomography (CT) scans from 7 patients with Korsakoff's syndrome, 7 age-matched alcoholic subjects, and 7 age-matched healthy control subjects. CT values were used to estimate tissue density and fluid volume in specified brain areas. Tissue density was assessed by averaging CT values in small (5 x 5 mm) areas sampled bilaterally in 6 specified areas--thalamus, head of the caudate nucleus, putamen, anterior white matter, posterior white matter, and centrum semiovale. We assessed fluid volume using a semiautomated computer algorithm that estimated the proportion of fluid in 7 brain regions--total ventricular space, third ventricle, interventricular region, frontal sulci, peri-Sylvian region, medial cerebellum, and vertex. For the patients with Korsakoff's syndrome, we also assessed the correlation between CT measures and performance on 6 cognitive and 12 memory tests. Compared with alcoholic subjects and healthy control subjects, patients with Korsakoff's syndrome had lower CT density values bilaterally in the region of the thalamus and had greater estimated fluid bilaterally in the region of the third ventricle. Alcoholic and healthy control subjects did not differ on these measures. Significant cortical atrophy in frontal sulcal and peri-Sylvian areas was detected both in patients with Korsakoff's syndrome and in alcoholic subjects. For patients with Korsakoff's syndrome, impairment on behavioral tests, and on memory tests in particular, was correlated with low-density values in the thalamus and with high fluid values in the region of the frontal sulci. Damage to diencephalic and frontal areas may especially contribute to the memory and cognitive impairment exhibited by patients with Korsakoff's syndrome. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Shimamura, A P AU - Jernigan, T L AU - Squire, L R AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 4400 EP - 4410 VL - 8 IS - 11 SN - 0270-6474, 0270-6474 KW - Index Medicus KW - Behavior KW - Humans KW - Middle Aged KW - Brain -- metabolism KW - Body Fluids -- metabolism KW - Neuropsychological Tests KW - Brain -- diagnostic imaging KW - Male KW - Female KW - Tomography, X-Ray Computed KW - Alcohol Amnestic Disorder -- psychology KW - Alcohol Amnestic Disorder -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78505754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Korsakoff%27s+syndrome%3A+radiological+%28CT%29+findings+and+neuropsychological+correlates.&rft.au=Shimamura%2C+A+P%3BJernigan%2C+T+L%3BSquire%2C+L+R&rft.aulast=Shimamura&rft.aufirst=A&rft.date=1988-11-01&rft.volume=8&rft.issue=11&rft.spage=4400&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-22 N1 - Date created - 1988-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oxidation of N-butyl-N-(3-formylpropyl)nitrosamine to N-butyl-N-(3-carboxypropyl)nitrosamine in rat liver and inhibition by disulfiram. AN - 78487082; 3180345 AB - The metabolism of N-butyl-N-(3-formylpropyl)nitrosamine, a presumptive intermediate metabolite of the urinary bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine, by rat liver has been examined. N-Butyl-N-(3-formylpropyl)nitrosamine was metabolized by an NADH-dependent reduction to N-butyl-N-(4-hydroxybutyl)nitrosamine and by an NAD+-dependent oxidation to N-butyl-N-(3-carboxypropyl)nitrosamine. The reduction of N-butyl-N-(3-formylpropyl)nitrosamine was inhibited by pyrazole. The oxidation of N-butyl-N-(3-formylpropyl)nitrosamine was studied further. The rate of oxidation in total rat liver was 3 mumol/min/g liver or 21 nmol/min/mg protein and was similar to that found for the oxidation of propionaldehyde, a model substrate for isozymes of rat liver aldehyde dehydrogenase. The rate of oxidation of N-butyl-N-(3-formylpropyl)nitrosamine by isozymes in rat liver cytosol was 2-2.5 times that found for propionaldehyde. The apparent Km for the NAD+-dependent oxidation of N-butyl-N-(3-formylpropyl)nitrosamine was 20-30 microM, which is considerably lower than values reported for known substrates of aldehyde dehydrogenase. The NAD+-dependent oxidation of N-butyl-N-(3-formylpropyl)nitrosamine was inhibited 40-50% by 50 microM disulfiram, 60-70% by 100 microM disulfiram, and 50% by 0.4 mM sodium arsenite. These studies show that N-butyl-N-(3-formylpropyl)nitrosamine is very rapidly oxidized to N-butyl-N-(3-carboxypropyl)nitrosamine in rat liver by aldehyde dehydrogenase and the results may help to explain why the 3-formylpropyl intermediate has not been directly identified as a metabolite of N-butyl-N-(4-hydroxybutyl)nitrosamine in urine or in isolated hepatocytes. JF - Carcinogenesis AU - Irving, C C AD - Research Service, Veterans Administration Medical Center, Memphis, TN. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 2109 EP - 2112 VL - 9 IS - 11 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Nitrosamines KW - NAD KW - 0U46U6E8UK KW - butyl(3-carboxypropyl)nitrosamine KW - 38252-74-3 KW - N-butyl-N-(3-formylpropyl)nitrosamine KW - 70625-89-7 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - NAD -- metabolism KW - Cytosol -- metabolism KW - Animals KW - Carcinogens -- metabolism KW - Male KW - Nitrosamines -- metabolism KW - Liver -- metabolism KW - Disulfiram -- pharmacology KW - Aldehyde Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78487082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Oxidation+of+N-butyl-N-%283-formylpropyl%29nitrosamine+to+N-butyl-N-%283-carboxypropyl%29nitrosamine+in+rat+liver+and+inhibition+by+disulfiram.&rft.au=Irving%2C+C+C&rft.aulast=Irving&rft.aufirst=C&rft.date=1988-11-01&rft.volume=9&rft.issue=11&rft.spage=2109&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-09 N1 - Date created - 1988-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal metabolism of formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide. AN - 78482724; 3180335 AB - Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide (FNT) is a potent renal carcinogen in the rat. This study assessed the metabolism of FNT by the isolated perfused rat kidney and whole rat. The glomerular filtration rate and the fractional excretion of sodium for the isolated perfused kidney indicated that under the conditions of these experiments FNT did not alter these renal parameters. The half-life (t1/2) for FNT in the isolated perfused kidney was 67 +/- 8 min. Using HPLC, a metabolite of FNT was observed in urine from the isolated perfused kidney. This metabolite had absorbance at 385 nm but not 254 nm and could not be detected electrochemically at +500 mV. While the excretion of FNT decreased with time of perfusion, the metabolite excretion increased. Whole animal studies demonstrated that FNT is rapidly cleared from blood within the first 5 min of administration. The FNT metabolite was excreted at approximately the same rate from 0-30 and 30-60 min after FNT administration. The metabolite was not observed in media from FNT perfused kidneys or plasma from animals administered FNT. Analysis of purified metabolite by liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS) determined the structure to be 5-nitro-2-furonitrile. This structure assignment was verified by chemical synthesis. Results demonstrate target organ metabolism of carcinogen. JF - Carcinogenesis AU - Ballal, S AU - Mattammal, M B AU - Lakshmi, V M AU - Spry, L A AU - Zenser, T V AU - Davis, B B AD - Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Medical Center, St Louis, MO 63125. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1975 EP - 1979 VL - 9 IS - 11 SN - 0143-3334, 0143-3334 KW - Nitrofurans KW - 0 KW - Xenobiotics KW - nefurthiazole KW - 3570-75-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Perfusion KW - Spectrum Analysis KW - Xenobiotics -- metabolism KW - Gas Chromatography-Mass Spectrometry KW - Chromatography, High Pressure Liquid KW - Kidney -- metabolism KW - Nitrofurans -- urine KW - Nitrofurans -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78482724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+metabolism+of+formic+acid+2-%5B4-%285-nitro-2-furyl%29-2-thiazolyl%5D-hydrazide.&rft.au=Ballal%2C+S%3BMattammal%2C+M+B%3BLakshmi%2C+V+M%3BSpry%2C+L+A%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Ballal&rft.aufirst=S&rft.date=1988-11-01&rft.volume=9&rft.issue=11&rft.spage=1975&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-09 N1 - Date created - 1988-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Topical antibiotics in dermatology. AN - 78480644; 2972259 AB - Topical antibiotics are safe and effective in certain conditions, primarily acne, rosacea, and nasal carriage of Staphylococcus aureus. They are useful in impetigo only when it is of limited extent. Their efficacy in other pyodermas is unclear, although mupirocin is probably effective in many cases. In "infected eczema" that does not require systemic therapy they seem to add little to what topical corticosteroids alone achieve. They are ineffective in reducing the incidence of significant infection with indwelling intravenous catheters. They are safe preparations, but extensive use, especially in closed populations, may encourage the emergence of resistant bacteria. JF - Archives of dermatology AU - Hirschmann, J V AD - Seattle Veterans Administration Center, Medical Service, WA 98108. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1691 EP - 1700 VL - 124 IS - 11 SN - 0003-987X, 0003-987X KW - Anti-Bacterial Agents KW - 0 KW - Soaps KW - Abridged Index Medicus KW - Index Medicus KW - Rosacea -- drug therapy KW - Eczema -- drug therapy KW - Pyoderma -- drug therapy KW - Administration, Cutaneous KW - Impetigo -- drug therapy KW - Acne Vulgaris -- drug therapy KW - Humans KW - Catheters, Indwelling -- adverse effects KW - Surgical Wound Infection -- prevention & control KW - Drug Resistance, Microbial KW - Skin Diseases -- drug therapy KW - Anti-Bacterial Agents -- therapeutic use KW - Anti-Bacterial Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78480644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Topical+antibiotics+in+dermatology.&rft.au=Hirschmann%2C+J+V&rft.aulast=Hirschmann&rft.aufirst=J&rft.date=1988-11-01&rft.volume=124&rft.issue=11&rft.spage=1691&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Blood alcohol measurements in the emergency department: who needs them? AN - 78477358; 3177726 AB - We surveyed North Carolina emergency physicians to determine current medical practices regarding the use of blood alcohol concentrations using a hypothetical scenario. Most physicians (88 per cent) would not have obtained blood alcohol concentrations in a patient who had alcohol on his breath but was coherent and cooperative. For marginally impaired patients, more liberal use of blood alcohol concentrations and explicit instructions to avoid driving while impaired might improve patient care and promote highway safety. JF - American journal of public health AU - Simel, D L AU - Feussner, J R AD - Ambulatory Care Service, Durham Veterans Administration Medical Center, NC 27705. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1478 EP - 1479 VL - 78 IS - 11 SN - 0090-0036, 0090-0036 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Motivation KW - Humans KW - Adult KW - Jurisprudence KW - Medical Staff, Hospital -- psychology KW - Defensive Medicine KW - Male KW - Ethanol -- blood KW - Wrist Injuries -- diagnosis KW - Emergencies KW - Alcoholic Intoxication -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78477358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Blood+alcohol+measurements+in+the+emergency+department%3A+who+needs+them%3F&rft.au=Simel%2C+D+L%3BFeussner%2C+J+R&rft.aulast=Simel&rft.aufirst=D&rft.date=1988-11-01&rft.volume=78&rft.issue=11&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-17 N1 - Date created - 1988-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1986 Jan 24-31;255(4):529-30 [3941537] Ann Emerg Med. 1986 Mar;15(3):349-53 [3511798] JAMA. 1986 Sep 19;256(11):1461-6 [3747064] J R Soc Med. 1987 Aug;80(8):486-9 [3656332] Arch Surg. 1987 Sep;122(9):1067-71 [3619621] Med J Aust. 1987 Jul 6;147(1):6-11 [3626939] J S C Med Assoc. 1986 Aug;82(8):536-7 [3463832] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Managing ICU-induced stress. AN - 78474109; 3177509 JF - The American journal of nursing AU - Doran, M O AD - Veterans Administration Medical Center, Denver, CO. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1559 EP - 60, 1562 VL - 88 IS - 11 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Hospital Bed Capacity, 300 to 499 KW - Humans KW - Burnout, Professional -- prevention & control KW - Colorado KW - Interprofessional Relations KW - Female KW - Nursing Staff, Hospital -- psychology KW - Intensive Care Units KW - Occupational Diseases -- psychology KW - Stress, Psychological -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78474109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Managing+ICU-induced+stress.&rft.au=Doran%2C+M+O&rft.aulast=Doran&rft.aufirst=M&rft.date=1988-11-01&rft.volume=88&rft.issue=11&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recovering from alcoholism--one shift at a time. AN - 78472821; 3177511 JF - The American journal of nursing AU - Saxe, D M AD - Alcohol Treatment Unit, Veterans Administration Medical Center, Wilmington, DE. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1618 VL - 88 IS - 11 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Humans KW - Nursing Staff, Hospital -- psychology KW - Alcoholism -- rehabilitation KW - Interprofessional Relations KW - Alcoholism -- psychology KW - Professional Impairment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78472821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Recovering+from+alcoholism--one+shift+at+a+time.&rft.au=Saxe%2C+D+M&rft.aulast=Saxe&rft.aufirst=D&rft.date=1988-11-01&rft.volume=88&rft.issue=11&rft.spage=1618&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aztreonam: critical evaluation of the first monobactam antibiotic in treatment of urinary tract infections. AN - 78466734; 3050153 JF - The Journal of urology AU - Madsen, P O AU - Nielsen, K T AU - Graversen, P H AD - Urology Section, Veterans Administration Hospital, Madison, Wisconsin. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 925 EP - 932 VL - 140 IS - 5 SN - 0022-5347, 0022-5347 KW - Aztreonam KW - G2B4VE5GH8 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Clinical Trials as Topic KW - Urinary Tract Infections -- drug therapy KW - Aztreonam -- pharmacokinetics KW - Aztreonam -- adverse effects KW - Aztreonam -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78466734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Aztreonam%3A+critical+evaluation+of+the+first+monobactam+antibiotic+in+treatment+of+urinary+tract+infections.&rft.au=Madsen%2C+P+O%3BNielsen%2C+K+T%3BGraversen%2C+P+H&rft.aulast=Madsen&rft.aufirst=P&rft.date=1988-11-01&rft.volume=140&rft.issue=5&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-17 N1 - Date created - 1988-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypocalcemia associated with estrogen therapy for metastatic adenocarcinoma of the prostate. AN - 78453794; 3172354 AB - We report 2 cases of true hypocalcemia (not caused by decreased binding proteins) associated with metastatic prostate cancer and review previously reported cases. Hypocalcemia is a common but frequently unrecognized complication of prostatic cancer. Estrogen therapy often is associated with the hypocalcemia, which may be asymptomatic. The hypocalcemia is always associated with osteoblastic metastases and usually it is associated with increased serum alkaline phosphatase activity, acid phosphatase activity and serum parathyroid hormone concentration. Serum concentrations of magnesium, phosphorus and vitamin D frequently are decreased. Patients are in a positive calcium balance. The osteoblastic metastases seem to act as a calcium sink, creating a "hungry tumor phenomenon". The role of estrogens may be to stop the resorption of normal bone resulting in lower serum calcium concentrations. JF - The Journal of urology AU - Vogelgesang, S A AU - McMillin, J M AD - Research Service, Sioux Falls Veterans Administration Hospital, South Dakota. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 1025 EP - 1027 VL - 140 IS - 5 SN - 0022-5347, 0022-5347 KW - Antineoplastic Agents KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Calcium -- metabolism KW - Bone Resorption -- drug effects KW - Humans KW - Aged KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Adenocarcinoma -- metabolism KW - Diethylstilbestrol -- therapeutic use KW - Diethylstilbestrol -- adverse effects KW - Bone Neoplasms -- metabolism KW - Bone Neoplasms -- drug therapy KW - Adenocarcinoma -- secondary KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Hypocalcemia -- chemically induced KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78453794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Hypocalcemia+associated+with+estrogen+therapy+for+metastatic+adenocarcinoma+of+the+prostate.&rft.au=Vogelgesang%2C+S+A%3BMcMillin%2C+J+M&rft.aulast=Vogelgesang&rft.aufirst=S&rft.date=1988-11-01&rft.volume=140&rft.issue=5&rft.spage=1025&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-17 N1 - Date created - 1988-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective immunity evoked by locally administered group A streptococcal vaccines in mice. AN - 78443078; 3049817 AB - The present studies were undertaken to determine the pathogenicity of group A streptococci introduced intranasally (i.n.) into mice in an attempt to mimic mucosal infections in humans and to determine the efficacy of streptococcal vaccines administered via the mucosal route. The LD50 of type 24 streptococci (M24 strep) administered i.n. was 3 x 10(4) CFU. Throat cultures were performed in M24 strep-inoculated mice. Of 11 mice that died, 9 had positive throat cultures 3 or 4 days after i.n. challenge, and of 9 mice that survived, only 1 had a positive throat culture, indicating an association between mucosal infection and death. Postmortem examination performed on 35 mice that died after i.n. challenge showed that all had evidence of disseminated infections, and group A streptococci were recovered from the cervical lymph nodes, blood, spleen, liver, and brain. To determine vaccine efficacy, heat-killed M24 strep or pep M24 were administered i.n. to groups of mice. Whole, heat-killed streptococci and pep M24 administered locally protected mice against death from i.n. challenge infections with homologous M24 strep. The whole cell vaccine also protected against i.n. challenge infections with heterologous type 6 streptococci. Our data suggest that streptococcal vaccines administered locally evoke protective immunity against streptococcal infections. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Bronze, M S AU - McKinsey, D S AU - Beachey, E H AU - Dale, J B AD - Veterans Administration Medical Center, Memphis, TN 38104. Y1 - 1988/10/15/ PY - 1988 DA - 1988 Oct 15 SP - 2767 EP - 2770 VL - 141 IS - 8 SN - 0022-1767, 0022-1767 KW - Antibodies, Bacterial KW - 0 KW - Antigens, Bacterial KW - Bacterial Vaccines KW - Polysaccharides, Bacterial KW - streptococcal polysaccharide group A KW - Abridged Index Medicus KW - Index Medicus KW - Saliva -- immunology KW - Animals KW - Streptococcal Infections -- prevention & control KW - Antigens, Bacterial -- immunology KW - Mice KW - Cross Reactions KW - Nasal Mucosa -- microbiology KW - Streptococcal Infections -- etiology KW - Myocardium -- immunology KW - Administration, Intranasal KW - Streptococcal Infections -- immunology KW - Lethal Dose 50 KW - Antigens, Bacterial -- administration & dosage KW - Antibodies, Bacterial -- biosynthesis KW - Female KW - Polysaccharides, Bacterial -- therapeutic use KW - Streptococcus pyogenes -- growth & development KW - Bacterial Vaccines -- therapeutic use KW - Streptococcus pyogenes -- immunology KW - Bacterial Vaccines -- administration & dosage KW - Polysaccharides, Bacterial -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78443078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Protective+immunity+evoked+by+locally+administered+group+A+streptococcal+vaccines+in+mice.&rft.au=Bronze%2C+M+S%3BMcKinsey%2C+D+S%3BBeachey%2C+E+H%3BDale%2C+J+B&rft.aulast=Bronze&rft.aufirst=M&rft.date=1988-10-15&rft.volume=141&rft.issue=8&rft.spage=2767&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-09 N1 - Date created - 1988-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Singlet oxygen production from the peroxidase-catalyzed oxidation of indole-3-acetic acid. AN - 78449209; 3170541 AB - The aerobic oxidation of indole-3-acetic acid catalyzed by horseradish peroxidase produces 1268 nm emission characteristic of singlet oxygen. Lactoperoxidase also oxidizes indole-3-acetic acid to produce singlet oxygen, but in contrast to horseradish peroxidase, this enzyme system requires hydrogen peroxide. In both of these systems, the intensity of the 1268 nm emission is small due to quenching of the singlet oxygen by indole-3-acetic acid and by reaction products derived from indole-3-acetic acid. The biomolecular reaction of peroxyl radicals via a Russell mechanism is a plausible mechanism for the singlet oxygen generation in these systems. Under typical conditions of p2H 4.0, 1 microM horseradish peroxidase, 1 mM indole-3-acetic acid, and 240 microM oxygen, the singlet oxygen yield was 15 +/- 1 microM or 13% of the amount predicted by the Russell mechanism. JF - The Journal of biological chemistry AU - Kanofsky, J R AD - Medical Service, Edward Hines, Jr., Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1988/10/05/ PY - 1988 DA - 1988 Oct 05 SP - 14171 EP - 14175 VL - 263 IS - 28 SN - 0021-9258, 0021-9258 KW - Indoleacetic Acids KW - 0 KW - Singlet Oxygen KW - 17778-80-2 KW - indoleacetic acid KW - 6U1S09C61L KW - Horseradish Peroxidase KW - EC 1.11.1.- KW - Lactoperoxidase KW - Peroxidases KW - Potassium Cyanide KW - MQD255M2ZO KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Photochemistry KW - Oxidation-Reduction KW - Luminescent Measurements KW - Kinetics KW - Hydrogen-Ion Concentration KW - Potassium Cyanide -- pharmacology KW - Indoleacetic Acids -- metabolism KW - Lactoperoxidase -- metabolism KW - Peroxidases -- metabolism KW - Horseradish Peroxidase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78449209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Singlet+oxygen+production+from+the+peroxidase-catalyzed+oxidation+of+indole-3-acetic+acid.&rft.au=Kanofsky%2C+J+R&rft.aulast=Kanofsky&rft.aufirst=J&rft.date=1988-10-05&rft.volume=263&rft.issue=28&rft.spage=14171&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-07 N1 - Date created - 1988-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Impaired Grammar with Normal Fluency and Phonology: Implications for Broca's Aphasia AN - 85488019; 8900131 AB - Extensive testing of grammatical function, including assessment of spontaneous lang, inflectional morphology, ability to produce grammatical structures, syntactic comprehension, & grammatical judgment, was carried out in two patients with large dominant frontal lobe lesions, including but not confined to, the third frontal convolution. Both Ss were fluent & had normal articulation & phonological production & neither was agrammatic, suggesting that even very large frontal lesions do not produce Broca's aphasia & that lang cortex proper is confined to the postcentral perisylvian region. Both Ss were impaired in the use of more complex syntactic structures & one, who in addition had severe generalized impairment in frontal lobe function, also had impaired judgment regarding the use & placement of functors. These data provide further support for the dissociability of syntactic & morphological aspects of grammar in aphasic patients &, together with other studies, link these functions with the frontal lobe & the postcentral perisylvian cortex, respectively. The sparing of grammatical judgment in one S, despite a very extensive lesion, suggests that very large portions of the frontal lobe are involved in grammatical function. The nature of frontal lobe function in syntax appears to be congruent with the role of the frontal lobes in other aspects of behavior. 9 Figures, 40 References. HA JF - Brain AU - Nadeau, Stephen E AD - Veterans Administration Medical Center, Gainesville FL 32602 Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 1111 EP - 1137 VL - 111 IS - 5 SN - 0006-8950, 0006-8950 KW - grammatical function testing, fluent/nonagrammatic frontal lobe lesion patients KW - Broca's aphasia implications KW - Neurolinguistics (ne3a) KW - Brain Anatomy (br1) KW - Phonology (ph13) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85488019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain&rft.atitle=Impaired+Grammar+with+Normal+Fluency+and+Phonology%3A+Implications+for+Broca%27s+Aphasia&rft.au=Nadeau%2C+Stephen+E&rft.aulast=Nadeau&rft.aufirst=Stephen&rft.date=1988-10-01&rft.volume=111&rft.issue=5&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Brain&rft.issn=00068950&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRAIAK N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Brain Anatomy (br1); Aphasia (ap1); Phonology (ph13) ER - TY - JOUR T1 - Gastroduodenal complications of chronic NSAID therapy. AN - 85226058; pmid-3048080 AB - The fact that nonsteroidal anti-inflammatory drugs (NSAIDs) damage the gastroduodenal mucosa is no longer contested. Endoscopic studies in normal volunteers after NSAID administration have failed to predict which NSAIDs would be safest when administered chronically. NSAID use has been associated with a disproportionately high frequency of upper gastrointestinal bleeding and perforation of ulcers. All of the newer NSAIDs appear to be similar in their propensity to cause mucosal damage, including peptic ulceration. On any given day, more than 10% of patients receiving NSAIDs chronically will have a gastric ulcer, a point prevalence of ulcer disease at least 5 to 10 times higher than in patients who are not taking NSAIDs. The dose-response relationship between anti-inflammatory activity and untoward events, coupled with increased use of newer more potent NSAIDs, explains, in part, the increased incidence of NSAID-associated ulcer complication of bleeding and perforation. The possible association of the increase in prevalence of Campylobacter pylori gastritis with aging and the apparent increase in NSAID-associated complications in the elderly is discussed. The current status of nonsteroidal drug therapy can be summarized as follows: 1) new NSAIDs are not safer than the old NSAIDs, as far as major gastrointestinal side effects are concerned, 2) NSAIDs should be avoided when analgesia is the main goal, 3) if NSAIDs are required, the lowest possible dose that achieves pain relief should be used, 4) newer NSAIDs available only in relatively high anti-inflammatory activity dosages should be restricted to those patients in whom high levels of anti-inflammatory activity are desired. JF - The American Journal of Gastroenterology AU - Graham, D Y AU - Smith, J L AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. PY - 1988 SP - 1081 EP - 1084 VL - 83 IS - 10 SN - 0002-9270, 0002-9270 KW - Dose-Response Relationship, Drug KW - Gastrointestinal Diseases KW - Human KW - Gastric Mucosa KW - Anti-Inflammatory Agents, Non-Steroidal KW - Duodenal Diseases KW - Peptic Ulcer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Gastroduodenal+complications+of+chronic+NSAID+therapy.&rft.au=Graham%2C+D+Y%3BSmith%2C+J+L&rft.aulast=Graham&rft.aufirst=D&rft.date=1988-10-01&rft.volume=83&rft.issue=10&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Carbohydrate malabsorption in alcoholic pancreatic insufficiency. The effect of pancreatic enzyme therapy on intestinal transit time. AN - 85211039; pmid-2460519 AB - The absorption of rice flour and the mouth-to-cecum transit time of a nonabsorbable carbohydrate were measured by breath hydrogen excretion technique in 10 patients with alcoholic pancreatic insufficiency, to evaluate the underlying mechanisms of carbohydrate malabsorption. Breath hydrogen excretion after ingestion of rice pancakes was significantly higher in patients than in 10 controls, suggesting malabsorption of carbohydrates. Mouth-to-cecum transit time was not significantly different between the two groups. Pancreatic enzyme therapy significantly reduced both fecal fat excretion and the degree of carbohydrate malabsorption, but, in contrast, did not significantly change mouth-to-cecum transit. There was no correlation between the degree of carbohydrate or fat malabsorption and mouth-to-cecum transit time. Carbohydrate malabsorption is common in pancreatic insufficiency and is markedly improved by enzyme supplementation. Mouth-to-cecum transit, however, does not play a major role in carbohydrate or fat malabsorption in these patients. JF - Journal of Clinical Gastroenterology AU - Keshavarzian, A AU - Dutta, S K AD - Gastroenterology Section, Veterans Administration Medical Center, Baltimore, Maryland. PY - 1988 SP - 528 EP - 532 VL - 10 IS - 5 SN - 0192-0790, 0192-0790 KW - Comparative Study KW - Human KW - Alcoholism KW - Amylases KW - Pancreatic Insufficiency KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Malabsorption Syndromes KW - Intestinal Absorption KW - Dietary Carbohydrates KW - Male KW - Breath Tests KW - Gastrointestinal Transit UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Carbohydrate+malabsorption+in+alcoholic+pancreatic+insufficiency.+The+effect+of+pancreatic+enzyme+therapy+on+intestinal+transit+time.&rft.au=Keshavarzian%2C+A%3BDutta%2C+S+K&rft.aulast=Keshavarzian&rft.aufirst=A&rft.date=1988-10-01&rft.volume=10&rft.issue=5&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Analysis of immunocompetent cells following inner ear immunostimulation. AN - 85190940; pmid-2971844 AB - Immunohistochemical methods were used to investigate the development of inner ear immunocompetent cells in healthy, BALB/c mice over a 3-week period as a result of a secondary inner ear response against keyhole limpet hemocyanin. Antibodies against murine macrophages and granulocytes (anti-Mac-1), T-cells (anti-Lyt-1, anti-Lyt-2), and immunoglobulins (anti-IgM, anti-IgG, anti-IgA) were used. Mac-1 positive (Mac-1+) cells were observed at 6 hours post-challenge in the endolymphatic sac and cochlea and rapidly increased in both sites. Lyt-1+ cells gradually increased in the endolymphatic sac after challenge, peaking at 2 and 3 weeks post-challenge. In the cochlea, Lyt-1+ cells were detected at 1 day post-challenge and then increased. Lyt-2+ cells were detectable in the endolymphatic sac and the cochlea by 3 weeks post-challenge. The predominant immunoglobulin-bearing cell in the endolymphatic sac was IgG, followed by IgM, with IgA seen late in the response. We conclude that the inner ear has the capacity to mount an immune response through the accumulation of the needed immunocompetent cells for antigen processing, antibody production, and modulation of the response through T-helper and suppressor cell activity. JF - The Laryngoscope AU - Takahashi, M AU - Harris, J P AD - Research Service, Veterans Administration Medical Center, San Diego, CA. PY - 1988 SP - 1133 EP - 1138 VL - 98 IS - 10 SN - 0023-852X, 0023-852X KW - Granulocytes KW - Macrophages KW - Labyrinth KW - Antigens KW - Support, U.S. Gov't, P.H.S. KW - Hemocyanin KW - T-Lymphocytes, Suppressor-Effector KW - Animal KW - Support, U.S. Gov't, Non-P.H.S. KW - T-Lymphocytes, Helper-Inducer KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85190940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Analysis+of+immunocompetent+cells+following+inner+ear+immunostimulation.&rft.au=Takahashi%2C+M%3BHarris%2C+J+P&rft.aulast=Takahashi&rft.aufirst=M&rft.date=1988-10-01&rft.volume=98&rft.issue=10&rft.spage=1133&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The general anesthesia induced by various drugs differentially affects analgesia and its variability. AN - 78742856; 3244717 AB - Responses to noxious stimuli in awake animals are not totally consensual but are influenced by environmental factors. We considered the possibility that the influence of the environment could be reduced by induction of general anesthesia. We, therefore, compared responses to nociceptive thermal stimuli by measuring tail flick latency, a spinal reflex, in anesthetized and awake mice. All anesthetics tested decreased the intraindividual variability in the measurement of response, suggesting that environmental factors may account for much of this variability in the awake mouse. Mice treated with pentobarbital showed a graded response to increasing levels of heat but were unresponsive to either morphine or naloxone. In mice anesthetized with pentobarbital, increases in latencies occurred only at very deep levels of anesthesia, while urethane nociceptive effect of ketamine was reversed by morphine. Thus, the various anesthetics could show differential effects towards opiate action. The decrease in statistical variability, the differential effects of general anesthetics on tail flick latency, and the distinctive effects of the different anesthetics on opiate action suggest that the anesthetized animal may be a useful tool in the study of nociception. JF - Pharmacology, biochemistry, and behavior AU - Banks, W A AU - Trentman, T L AU - Kastin, A J AU - Galina, Z H AD - Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 397 EP - 403 VL - 31 IS - 2 SN - 0091-3057, 0091-3057 KW - Naloxone KW - 36B82AMQ7N KW - Urethane KW - 3IN71E75Z5 KW - Ketamine KW - 690G0D6V8H KW - Morphine KW - 76I7G6D29C KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Reaction Time -- drug effects KW - Naloxone -- pharmacology KW - Animals KW - Dose-Response Relationship, Drug KW - Pain Measurement KW - Mice KW - Urethane -- pharmacology KW - Male KW - Pentobarbital -- pharmacology KW - Morphine -- pharmacology KW - Ketamine -- pharmacology KW - Analgesia KW - Anesthesia, General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78742856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=The+general+anesthesia+induced+by+various+drugs+differentially+affects+analgesia+and+its+variability.&rft.au=Banks%2C+W+A%3BTrentman%2C+T+L%3BKastin%2C+A+J%3BGalina%2C+Z+H&rft.aulast=Banks&rft.aufirst=W&rft.date=1988-10-01&rft.volume=31&rft.issue=2&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-06 N1 - Date created - 1989-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuropsychological performance of young nondrinkers, social drinkers, and long- and short-term sober alcoholics. AN - 78673321; 3067605 AB - Neuropsychological performance of 23-42-year-old males with diverse drinking histories was assessed. Comparisons were made among nondrinkers, social drinkers, short-term sober (less than 30 days) alcoholics and long-term sober (greater than 30 days) alcoholics. Results of these comparisons provided little support for the notion that neurotoxic effects of chronic alcohol consumption are directly related to cognitive impairment. Instead, these results suggested that performance differences among the groups were more closely related to subclinical withdrawal symptoms or native ability than to long-term alcohol consumption. Because none of the dependent measures was related to length of abstinence, and because Wechsler's Adult Intelligence Scale-R Vocabulary differences among groups paralleled neuropsychological test performance differences, it is suggested that differences among groups may reflect differences in native ability. In addition, there were no differences between social drinkers and nondrinkers, nor were there any significant correlations among drinking variables and performance of social drinkers, providing further evidence against a direct relationship between alcohol consumption and cognitive performance. JF - Alcoholism, clinical and experimental research AU - Emmerson, R Y AU - Dustman, R E AU - Heil, J AU - Shearer, D E AD - Neuropsychology Research Laboratory, Veterans Administration Medical Center, Salt Lake City, UT 84148. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 625 EP - 629 VL - 12 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Substance-Related Disorders -- psychology KW - Male KW - Alcoholism -- rehabilitation KW - Alcohol Drinking -- psychology KW - Neuropsychological Tests KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78673321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Neuropsychological+performance+of+young+nondrinkers%2C+social+drinkers%2C+and+long-+and+short-term+sober+alcoholics.&rft.au=Emmerson%2C+R+Y%3BDustman%2C+R+E%3BHeil%2C+J%3BShearer%2C+D+E&rft.aulast=Emmerson&rft.aufirst=R&rft.date=1988-10-01&rft.volume=12&rft.issue=5&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Loss of cholinergic muscarinic receptors in the frontal cortex of alcohol abusers. AN - 78671696; 3067606 AB - Alcohol abuse causes impairment of cognitive function ranging from mild forms to end-stage dementia. Alcohol-related dementia accounts for nearly 20% of all admissions to state mental hospitals and may result from head trauma, thiamine deficiency, Alzheimer's, and other brain diseases that can be diagnosed conclusively only at autopsy. However, we postulate that after all these conditions have been excluded, an "alcohol encephalopathy" remains. This is characterized by impaired synaptic function, which underlies the continuum of impaired intellectual function. We found in 79 histologically normal brains of a nondemented general hospital population a 40% decrease in the density of cholinergic muscarinic receptors in the frontal cortex of alcoholics when compared with matched controls of the same age. Only alcohol abuse and not aging, postmortem changes, medications, clinical (including liver) diseases, or differences in causes of death could account for this loss. JF - Alcoholism, clinical and experimental research AU - Freund, G AU - Ballinger, W E AD - Veterans Administration Medical Center, Medical Service, Gainesville, FL 32602. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 630 EP - 638 VL - 12 IS - 5 SN - 0145-6008, 0145-6008 KW - Receptors, Muscarinic KW - 0 KW - Quinuclidinyl Benzilate KW - 6581-06-2 KW - Index Medicus KW - Lung Diseases, Obstructive -- pathology KW - Age Factors KW - Postmortem Changes KW - Quinuclidinyl Benzilate -- pharmacokinetics KW - Humans KW - Middle Aged KW - Radioligand Assay KW - Cause of Death KW - Frontal Lobe -- pathology KW - Alcoholism -- pathology KW - Frontal Lobe -- drug effects KW - Receptors, Muscarinic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78671696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Loss+of+cholinergic+muscarinic+receptors+in+the+frontal+cortex+of+alcohol+abusers.&rft.au=Freund%2C+G%3BBallinger%2C+W+E&rft.aulast=Freund&rft.aufirst=G&rft.date=1988-10-01&rft.volume=12&rft.issue=5&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Plasma carnitine in alcoholism. AN - 78671482; 3067607 AB - Carnitine is essential for the beta-oxidation of long-chain fatty acids in the mitochondria and probably has a major role in modulating the acyl-coenzyme A/reduced coenzyme A ratio in the matrix of mitochondria. Plasma carnitine concentrations are elevated in several conditions and reflect changes at the cellular level. We previously had reported elevated plasma carnitine in patients with alcoholic liver disease compared to healthy control subjects. In this study we measured plasma carnitine in a third group, alcoholic patients without overt liver disease. The alcoholic patients (n = 20) had significantly elevated plasma long-chain acylcarnitine (P less than 0.01) compared to 32 healthy men of identical age and significantly lower short-chain (P less than 0.01) and long-chain acylcarnitine (P less than 0.01) than 28 men with alcoholic liver disease. We conclude that alcoholism is another condition in which carnitine homeostasis is altered. JF - Alcoholism, clinical and experimental research AU - Fuller, R K AU - Hoppel, C L AD - Veterans Administration Medical Center, Cleveland, OH 44106. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 639 EP - 642 VL - 12 IS - 5 SN - 0145-6008, 0145-6008 KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Liver Cirrhosis, Alcoholic -- blood KW - Humans KW - Adult KW - Middle Aged KW - Liver Function Tests KW - Male KW - Alcoholism -- rehabilitation KW - Carnitine -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78671482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Plasma+carnitine+in+alcoholism.&rft.au=Fuller%2C+R+K%3BHoppel%2C+C+L&rft.aulast=Fuller&rft.aufirst=R&rft.date=1988-10-01&rft.volume=12&rft.issue=5&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of ultraviolet radiation and PUVA on mediator release from purified mast cells. AN - 78662452; 3222170 AB - Exposure of highly purified rat serosal mast cells to UVA (34-340 kJ/m2), in the presence or absence of 8-methoxypsoralen (100 ng/ml), or to UVB (160-640 J/m2), resulted in dose-dependent releases of mast cell preformed mediators, as measured by the release of radioactivity from 3H-serotonin-labeled cells. The net release ranged from 2.3% to 14.2%. The above treatments had no effect on mediator release induced by subsequent incubation with calcium ionophore A23187 (0.4 and 4.0 mumol/l) or with compound 48/80 (1.0 microgram/ml), with the exception that exposure to UVB did suppress the release induced by the latter. These results indicate that under clinically relevant conditions, the direct effect of in vitro ultraviolet radiation on mast cells did not alter the ability of these cells to respond to subsequent stimulation with secretagogues. JF - Photo-dermatology AU - Mandel, M J AU - Lim, H W AD - Dermatology Service, New York Veterans Administration Medical Center, New York. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 211 EP - 217 VL - 5 IS - 5 SN - 0108-9684, 0108-9684 KW - Tritium KW - 10028-17-8 KW - Serotonin KW - 333DO1RDJY KW - Methoxsalen KW - U4VJ29L7BQ KW - Index Medicus KW - Rats KW - Radiation Dosage KW - Animals KW - Cell Survival -- drug effects KW - Cell Survival -- radiation effects KW - Serotonin -- metabolism KW - Methoxsalen -- adverse effects KW - Ultraviolet Rays KW - Mast Cells -- metabolism KW - Mast Cells -- radiation effects KW - PUVA Therapy KW - Mast Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78662452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photo-dermatology&rft.atitle=Effect+of+ultraviolet+radiation+and+PUVA+on+mediator+release+from+purified+mast+cells.&rft.au=Mandel%2C+M+J%3BLim%2C+H+W&rft.aulast=Mandel&rft.aufirst=M&rft.date=1988-10-01&rft.volume=5&rft.issue=5&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Photo-dermatology&rft.issn=01089684&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-20 N1 - Date created - 1989-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term memory in amnesia: cued recall, recognition memory, and confidence ratings. AN - 78507075; 2972808 AB - We explored what kind of information is acquired when amnesic patients are able to exhibit significant retention on tests of cued recall and recognition memory. Amnesic patients and control subjects attempted to learn sets of sentences. Memory for the last word in each sentence was tested after 1 hr in the case of the amnesic patients, or after 1 to 2 weeks in the case of (delayed) control subjects. Amnesic patients and (delayed) control subjects performed at similar levels on tests of cued recall and recognition memory. Amnesic patients were just as confident of their correct answers as were control subjects. However, amnesic patients were no more disadvantaged than control subjects when they were cued indirectly by presenting paraphrases of the original sentences. These findings demonstrate that the residual knowledge retained by amnesic patients can be as flexible, as accessible to indirect cues, and as available to awareness as the knowledge retained by (delayed) control subjects. JF - Journal of experimental psychology. Learning, memory, and cognition AU - Shimamura, A P AU - Squire, L R AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 763 EP - 770 VL - 14 IS - 4 SN - 0278-7393, 0278-7393 KW - Index Medicus KW - Verbal Learning KW - Brain Ischemia -- psychology KW - Neurocognitive Disorders -- psychology KW - Humans KW - Alcohol Amnestic Disorder -- psychology KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Female KW - Brain Damage, Chronic -- psychology KW - Memory KW - Cues KW - Awareness KW - Mental Recall KW - Amnesia -- psychology KW - Retention (Psychology) KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78507075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+psychology.+Learning%2C+memory%2C+and+cognition&rft.atitle=Long-term+memory+in+amnesia%3A+cued+recall%2C+recognition+memory%2C+and+confidence+ratings.&rft.au=Shimamura%2C+A+P%3BSquire%2C+L+R&rft.aulast=Shimamura&rft.aufirst=A&rft.date=1988-10-01&rft.volume=14&rft.issue=4&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+psychology.+Learning%2C+memory%2C+and+cognition&rft.issn=02787393&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-06 N1 - Date created - 1988-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pertussis toxin-sensitive cholinergic inhibition of somatostatin release from canine D-cells. AN - 78492274; 2902802 AB - Development of an enriched cultured cell system allowed us to investigate the mechanism of cholinergic inhibition of somatostatin release stimulated by adenosine 3',5'-cyclic monophosphate (cAMP) and Ca2+-protein kinase C-dependent pathways of cell activation. After a 24-h culture on rat tail collagen, D-cells, quantified by immunohistochemistry, were 18-fold enriched compared with unelutriated dispersed cells. Somatostatin release from cultured cells was expressed as a percent of the somatostatin released by a specific stimulus in control cells. Under basal conditions release of somatostatin was 2.3 +/- 0.6% of the total cell content. Epinephrine (1 microM) and cholecystokinin octapeptide (10 nM) increased somatostatin release to 6.98 +/- 1.25 and 10.72 +/- 1.64%, respectively. Carbachol (1 microM) completely inhibited somatostatin release stimulated by epinephrine and reduced cholecystokinin octapeptide-stimulated release to 75% of control levels. Carbachol inhibition of the response to both epinephrine and cholecystokinin octapeptide was totally prevented by 5 h of treatment of the cells with pertussis toxin (300 ng/ml). Somatostatin release in response to the diterpene forskolin (10 microM), dibutyryl cAMP (300 microM), the phorbol ester beta-phorbol 12-myristate 13-acetate (0.1 microM), and the calcium ionophore A23187 (1 microM) was also inhibited by carbachol and prevented by pertussis toxin pretreatment. The ADP-ribosylase inhibitor isonicotinamide (1 mM) selectively blocked the effect of pertussis toxin without altering other stimulatory or inhibitory responses. These data are consistent with the view that carbachol inhibits somatostatin release at guanyl nucleotide-binding protein and/or another pertussis toxin-sensitive site. JF - The American journal of physiology AU - Chan, C B AU - Soll, A H AD - Center for Ulcer Research and Education, Veterans Administration Wadsworth Medical and Research Services, Los Angeles, California. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - G424 EP - G428 VL - 255 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Virulence Factors, Bordetella KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - Calcimycin KW - 37H9VM9WZL KW - Somatostatin KW - 51110-01-1 KW - Bucladesine KW - 63X7MBT2LQ KW - Carbachol KW - 8Y164V895Y KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Sincalide KW - M03GIQ7Z6P KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Gastric Fundus KW - Animals KW - Reference Values KW - Colforsin -- pharmacology KW - Cells, Cultured KW - Kinetics KW - Epinephrine -- pharmacology KW - Dogs KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Calcimycin -- pharmacology KW - Bucladesine -- pharmacology KW - Sincalide -- pharmacology KW - Virulence Factors, Bordetella -- pharmacology KW - Somatostatin -- secretion KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- cytology KW - Gastric Mucosa -- secretion KW - Carbachol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78492274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Pertussis+toxin-sensitive+cholinergic+inhibition+of+somatostatin+release+from+canine+D-cells.&rft.au=Chan%2C+C+B%3BSoll%2C+A+H&rft.aulast=Chan&rft.aufirst=C&rft.date=1988-10-01&rft.volume=255&rft.issue=4+Pt+1&rft.spage=G424&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-10 N1 - Date created - 1988-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biodistribution and radiation dosimetry of radioiodinated-SCH 23982, a potential dopamine D-1 receptor imaging agent. AN - 78458529; 3262726 AB - Radioiodinated-SCH 23982 is a potential agent for the imaging of dopamine D-1 receptors in the human brain. In vivo binding of [125I]SCH 23982 to D-1 receptors in rat brain was determined over 4 hr. The ratio of activity in striatum and frontal cortex to that in cerebellum increased over the first 2 hr to maximum values of 4.4:1 and 2.1:1, respectively. The percent injected dose in whole brain at 0.5 and 2 hr were 0.62 and 0.15, respectively. Administration of the antagonists propranolol (beta-1), prazosin (alpha-1), haloperidol (D-2) and ketanserin (5HT-2) did not significantly alter the striatum/cerebellum ratio; however, SCH 23390, a D-1 antagonist, totally blocked ligand uptake by striatum and frontal cortex. Biologic distribution data in the rat were determined after injection of 3 microCi of [125I]SCH 23982. 76% of the injected dose was excreted in 48 hr via the liver and kidneys. Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads and red bone marrow were calculated for humans using the physical decay data for 123I. The critical organ was found to be the lower large intestine which received 1.1 rad/mCi of the administered dose. The total-body dose was 63 mrad/mCi. The data indicate that [123I]SCH 23982 should be a suitable agent for imaging the D-1 dopamine receptor in the human brain by single photon emission computed tomography. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Thonoor, C M AU - Couch, M W AU - Greer, D M AU - Thomas, K D AU - Williams, C M AD - Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 1668 EP - 1674 VL - 29 IS - 10 SN - 0161-5505, 0161-5505 KW - 8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol KW - 0 KW - Benzazepines KW - Dopamine Antagonists KW - Iodine Radioisotopes KW - Receptors, Dopamine KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Radiation Dosage KW - Animals KW - Receptors, Dopamine -- analysis KW - Tissue Distribution KW - Male KW - Tomography, Emission-Computed KW - Brain -- diagnostic imaging KW - Benzazepines -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78458529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Biodistribution+and+radiation+dosimetry+of+radioiodinated-SCH+23982%2C+a+potential+dopamine+D-1+receptor+imaging+agent.&rft.au=Thonoor%2C+C+M%3BCouch%2C+M+W%3BGreer%2C+D+M%3BThomas%2C+K+D%3BWilliams%2C+C+M&rft.aulast=Thonoor&rft.aufirst=C&rft.date=1988-10-01&rft.volume=29&rft.issue=10&rft.spage=1668&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-10 N1 - Date created - 1988-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of a nosocomial Clostridium difficile outbreak by using plasmid profile typing and clindamycin susceptibility testing. AN - 78457469; 2844914 AB - The mean number of cases of Clostridium difficile diarrhea at the Minneapolis Veterans Administration Medical Center increased to 17.3 per month in June-August 1985, compared with 7.1 per month in the previous 17 mo. Plasmid profiles and clindamycin susceptibility were used as markers to evaluate the increase in cases. Ninety clindamycin-resistant and 22 clindamycin-susceptible isolates of C. difficile from 1985 were examined for plasmids. A clindamycin-resistant organism contained a cryptic plasmid of 3.1 kilobases (kb). None of the clindamycin-susceptible isolates contained the 3.1-kb plasmid, as compared with 40 of 90 clindamycin-resistant isolates (P less than .005). Restriction endonuclease digestion and Southern blot hybridization were used to confirm the identity of the 3.1-kb plasmid between strains. Isolates retained clindamycin resistance after plasmid curing. It could not be determined if the organism responsible was an indigenous C. difficile strain that acquired a plasmid or was a new strain introduced from outside the hospital. JF - The Journal of infectious diseases AU - Clabots, C R AU - Peterson, L R AU - Gerding, D N AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 731 EP - 736 VL - 158 IS - 4 SN - 0022-1899, 0022-1899 KW - Bacterial Toxins KW - 0 KW - Cytotoxins KW - DNA, Bacterial KW - Clindamycin KW - 3U02EL437C KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Abridged Index Medicus KW - Index Medicus KW - Blotting, Southern KW - Humans KW - Clindamycin -- pharmacology KW - Plasmids KW - DNA, Bacterial -- analysis KW - Bacterial Toxins -- biosynthesis KW - Cytotoxins -- biosynthesis KW - Clostridium -- drug effects KW - Enterocolitis, Pseudomembranous -- epidemiology KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Clostridium -- classification KW - Disease Outbreaks KW - Clostridium -- genetics KW - Enterocolitis, Pseudomembranous -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78457469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Characterization+of+a+nosocomial+Clostridium+difficile+outbreak+by+using+plasmid+profile+typing+and+clindamycin+susceptibility+testing.&rft.au=Clabots%2C+C+R%3BPeterson%2C+L+R%3BGerding%2C+D+N&rft.aulast=Clabots&rft.aufirst=C&rft.date=1988-10-01&rft.volume=158&rft.issue=4&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-09 N1 - Date created - 1988-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of pyrazinamide in tuberculosis chemotherapy. AN - 78438229; 3048929 AB - Pyrazinamide is an antituberculosis drug synthesized in the 1950s and formerly used only as salvage therapy. Recent developments have elevated it to a central role in tuberculosis chemotherapy as the essential addition to isoniazid and rifampin which makes it possible to successfully complete treatment in six months. This is accomplished with no increase in hepatotoxicity. The only substantial side effect of this drug given at the dosage and for the duration used in these six-month regimens is a polyarthralgia which is only bothersome and not sufficient to warrant interruption of therapy. More rarely, acute gout is produced. The early history and pharmacology of this now first line antituberculosis drug are reviewed herein. JF - Chest AU - Steele, M A AU - Des Prez, R M AD - Veterans Administration Medical Center, Nashville 37203. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 845 EP - 850 VL - 94 IS - 4 SN - 0012-3692, 0012-3692 KW - Pyrazinamide KW - 2KNI5N06TI KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Pyrazinamide -- adverse effects KW - Pyrazinamide -- therapeutic use KW - Pyrazinamide -- pharmacokinetics KW - Tuberculosis, Pulmonary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78438229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=The+role+of+pyrazinamide+in+tuberculosis+chemotherapy.&rft.au=Steele%2C+M+A%3BDes+Prez%2C+R+M&rft.aulast=Steele&rft.aufirst=M&rft.date=1988-10-01&rft.volume=94&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-03 N1 - Date created - 1988-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Endogenous opioids in cerebrospinal fluid of opioid-dependent humans. AN - 78433968; 2844315 AB - Endogenous opioid systems may be altered as a consequence of addiction, but evidence to support this idea is meager so far. We obtained 136 cerebrospinal fluid (CSF) samples from 72 opioid addicts during four distinct states: methadone maintenance, detoxification from methadone, opioid antagonist treatment, and drug-free status. CSF endorphins were measured in 86 patients samples using a radioreceptor assay (RRA), and beta-endorphin levels were measured in 85 patient samples using a radioimmuno assay (RIA). During detoxification, both RRA fraction I and beta-endorphin showed a generally similar pattern of changes. Both were lowest when measured 40-50 hr after the last opioid dose, and both showed an apparent rebound to higher than methadone maintenance values at 60-70 hr following the last dose. During methadone maintenance and drug-free states, the addicts' levels of fraction I RRA endorphins in the CSF were higher than levels found in a normal control group. Fraction II endorphins were also elevated in the addicts who were drug free. In contrast, CSF beta-endorphin during both methadone maintenance and drug-free states was lower in the addicts as compared to the normal, drug-naive group. Except for the pattern found during detoxification, there were no consistent changes in endorphin levels across different states of addiction. JF - Biological psychiatry AU - O'Brien, C P AU - Terenius, L Y AU - Nyberg, F AU - McLellan, A T AU - Eriksson, I AD - Veterans Administration Medical Center, University of Pennsylvania, Philadelphia 19104. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 649 EP - 662 VL - 24 IS - 6 SN - 0006-3223, 0006-3223 KW - Receptors, Opioid KW - 0 KW - Naltrexone KW - 5S6W795CQM KW - beta-Endorphin KW - 60617-12-1 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Humans KW - Adult KW - Radioligand Assay KW - Substance Withdrawal Syndrome -- cerebrospinal fluid KW - Radioimmunoassay KW - Male KW - Naltrexone -- therapeutic use KW - Receptors, Opioid -- metabolism KW - beta-Endorphin -- cerebrospinal fluid KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78433968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Endogenous+opioids+in+cerebrospinal+fluid+of+opioid-dependent+humans.&rft.au=O%27Brien%2C+C+P%3BTerenius%2C+L+Y%3BNyberg%2C+F%3BMcLellan%2C+A+T%3BEriksson%2C+I&rft.aulast=O%27Brien&rft.aufirst=C&rft.date=1988-10-01&rft.volume=24&rft.issue=6&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combined use of calcium-channel and beta-adrenergic blockers for the treatment of chronic stable angina. Rationale, efficacy, and adverse effects. AN - 78427898; 2901816 AB - During the past decade, the therapy for stable angina pectoris has greatly expanded with the introduction of the calcium-channel blockers. Initially studied as monotherapy, these agents have been regularly used in combination with other antianginal medications, most notably the beta-adrenergic blockers. Although there are pharmacologic rationales for combining these agents, in daily practice, the major impetus for combination therapy is continuing angina during monotherapy. At least one well-conducted double-blind study was done to confirm that diltiazem, verapamil, and nifedipine each can markedly improve both subjective and objective measures of efficacy when used in combination with a beta-blocker. However, individual patient responses are of chief importance. Many persons do better with monotherapy than with combination treatment. The offsetting hemodynamic effects of nifedipine and a beta-blocker generally work well together; however, minor side effects are not infrequent. In the patient with underlying conduction system disease, this combination is clearly preferable. Diltiazem with a beta-blocker is usually well-tolerated, with a low incidence of adverse effects, similar to the experience with diltiazem monotherapy. Verapamil in conjunction with a beta-blocker warrants the greatest concern; approximately 10% to 15% of patients will have significant bradycardia, heart block, hypotension, or congestive failure. When these agents are used concurrently, reduced dosages, especially of the beta-blocker, will likely result in a lower incidence of adverse effects with maintained efficacy. JF - Annals of internal medicine AU - Strauss, W E AU - Parisi, A F AD - Veterans Administration Medical Center, West Roxbury, Massachusetts. Y1 - 1988/10/01/ PY - 1988 DA - 1988 Oct 01 SP - 570 EP - 581 VL - 109 IS - 7 SN - 0003-4819, 0003-4819 KW - Adrenergic beta-Antagonists KW - 0 KW - Calcium Channel Blockers KW - Verapamil KW - CJ0O37KU29 KW - Diltiazem KW - EE92BBP03H KW - Nifedipine KW - I9ZF7L6G2L KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Nifedipine -- therapeutic use KW - Humans KW - Cardiovascular Diseases -- chemically induced KW - Verapamil -- therapeutic use KW - Diltiazem -- therapeutic use KW - Adrenergic beta-Antagonists -- administration & dosage KW - Angina Pectoris -- drug therapy KW - Calcium Channel Blockers -- adverse effects KW - Calcium Channel Blockers -- administration & dosage KW - Adrenergic beta-Antagonists -- adverse effects KW - Adrenergic beta-Antagonists -- therapeutic use KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78427898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Combined+use+of+calcium-channel+and+beta-adrenergic+blockers+for+the+treatment+of+chronic+stable+angina.+Rationale%2C+efficacy%2C+and+adverse+effects.&rft.au=Strauss%2C+W+E%3BParisi%2C+A+F&rft.aulast=Strauss&rft.aufirst=W&rft.date=1988-10-01&rft.volume=109&rft.issue=7&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-25 N1 - Date created - 1988-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Slowed growth of cultured fibroblasts from human radiation wounds. AN - 78427107; 3420190 AB - To study radiation effect separate from the microcirculation, fibroblasts were cultured from four patients with radiation wounds. Cells could be grown from irradiated tissue near the ulcer and from control normal tissue, but no cells could be cultured from the ulcers. The ability of radiation-treated fibroblasts to attach to the substrate and form colonies was less than that of unirradiated cells. Irradiated skin fibroblasts from the four patients had significantly longer mean generation times than did control cells. During log-phase growth (1 to 9 days), the population doublings of damaged cells were significantly reduced compared to colonies from normal cells. These data suggest a permanent intrinsic radiation effect on fibroblasts or a selective ablation of faster-growing fibroblast subpopulations that is not dependent on decreased blood supply. JF - Plastic and reconstructive surgery AU - Rudolph, R AU - Vande Berg, J AU - Schneider, J A AU - Fisher, J C AU - Poolman, W L AD - San Diego Veterans Administration Medical Center, La Jolla, Calif. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 669 EP - 677 VL - 82 IS - 4 SN - 0032-1052, 0032-1052 KW - Abridged Index Medicus KW - Index Medicus KW - Karyotyping KW - Skin Ulcer -- etiology KW - Cells, Cultured KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Skin Ulcer -- pathology KW - Radiotherapy -- adverse effects KW - Cell Division KW - Radiation Injuries -- genetics KW - Skin -- radiation effects KW - Fibroblasts -- pathology KW - Skin -- pathology KW - Radiation Injuries -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78427107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+and+reconstructive+surgery&rft.atitle=Slowed+growth+of+cultured+fibroblasts+from+human+radiation+wounds.&rft.au=Rudolph%2C+R%3BVande+Berg%2C+J%3BSchneider%2C+J+A%3BFisher%2C+J+C%3BPoolman%2C+W+L&rft.aulast=Rudolph&rft.aufirst=R&rft.date=1988-10-01&rft.volume=82&rft.issue=4&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Plastic+and+reconstructive+surgery&rft.issn=00321052&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-18 N1 - Date created - 1988-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function. AN - 78401395; 3046744 AB - The purpose of this investigation was to understand the biological effects of recombinant human tumor necrosis factor used as therapy for cancer. We studied changes in mononuclear phagocyte function following exposure to this cytokine in vitro or in vivo. Tumor necrosis factor increased phorbol myristate acetate-induced hydrogen peroxide production 8- to 20-fold in peripheral blood monocytes and peritoneal macrophages in vitro in a dose-dependent manner. Similarly, tumor necrosis factor increased phorbol myristate acetate-induced peroxide production 2.3-fold in monocytes isolated from nine patients following an i.v. infusion of this cytokine (40 to 200 micrograms/m2). In addition, tumor necrosis factor induced a 2.3-fold increase in tissue factor-like activity in mononuclear phagocytes in vitro. In vivo, tumor necrosis factor induced a trend toward higher procoagulant activity in monocytes, although this change was not statistically significant. We also noted a trend toward increased activated partial thromboplastin times and the presence of fibrin D-dimer in patients treated with tumor necrosis factor, demonstrating activation of the coagulation and fibrinolytic systems. Thus, in vivo treatment of humans with i.v. recombinant human tumor necrosis factor induced functional changes in mononuclear phagocytes similar to those noted with in vitro treatment. JF - Cancer research AU - Conkling, P R AU - Chua, C C AU - Nadler, P AU - Greenberg, C S AU - Doty, E AU - Misukonis, M A AU - Haney, A F AU - Bast, R C AU - Weinberg, J B AD - Department of Medicine, Veterans Administration Medical Center, Durham, North Carolina. Y1 - 1988/10/01/ PY - 1988 DA - 1988 Oct 01 SP - 5604 EP - 5609 VL - 48 IS - 19 SN - 0008-5472, 0008-5472 KW - Blood Coagulation Factors KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - macrophage procoagulant activity KW - Hydrogen Peroxide KW - BBX060AN9V KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Neoplasms -- drug therapy KW - Humans KW - Clinical Trials as Topic KW - Hydrogen Peroxide -- blood KW - Macrophages -- drug effects KW - Drug Evaluation KW - Monocytes -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects KW - Blood Coagulation Factors -- analysis KW - Female KW - Recombinant Proteins -- therapeutic use KW - Macrophages -- metabolism KW - Tumor Necrosis Factor-alpha -- therapeutic use KW - Phagocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78401395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Clinical+trials+with+human+tumor+necrosis+factor%3A+in+vivo+and+in+vitro+effects+on+human+mononuclear+phagocyte+function.&rft.au=Conkling%2C+P+R%3BChua%2C+C+C%3BNadler%2C+P%3BGreenberg%2C+C+S%3BDoty%2C+E%3BMisukonis%2C+M+A%3BHaney%2C+A+F%3BBast%2C+R+C%3BWeinberg%2C+J+B&rft.aulast=Conkling&rft.aufirst=P&rft.date=1988-10-01&rft.volume=48&rft.issue=19&rft.spage=5604&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-25 N1 - Date created - 1988-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury. AN - 78388576; 3410220 AB - Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy specimens of 68 alcoholic and 39 nonalcoholic patients with alcohollike injury on liver biopsy were compared. The clinical and biochemical features of the two groups differed significantly. Alcoholism was associated with more severe clinical and biochemical manifestations of liver disease. However, there was considerable overlap among histologic features of the two clinically defined groups. Based on histology alone, alcoholic and nonalcoholic patients were often indistinguishable. The observations suggest that the clinical differences between the alcoholic and non-alcoholic patients cannot be attributed to qualitative or quantitative differences in liver histology. On the other hand, histologic similarities between the two groups raise the possibility that a shared condition, perhaps nutritional or hormonal, is responsible for the histologic expression of alcohollike injury in both groups. JF - Gastroenterology AU - Diehl, A M AU - Goodman, Z AU - Ishak, K G AD - Department of Medicine, Veterans Administration Medical Center, Washington, D.C. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 1056 EP - 1062 VL - 95 IS - 4 SN - 0016-5085, 0016-5085 KW - Abridged Index Medicus KW - Index Medicus KW - Fatty Liver, Alcoholic -- blood KW - Liver Cirrhosis, Alcoholic -- blood KW - Liver Cirrhosis, Alcoholic -- pathology KW - Humans KW - Fatty Liver, Alcoholic -- pathology KW - Biopsy KW - Alcohol Drinking KW - Male KW - Female KW - Liver Cirrhosis -- pathology KW - Liver -- pathology KW - Fatty Liver -- blood KW - Fatty Liver -- pathology KW - Liver Cirrhosis -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78388576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Alcohollike+liver+disease+in+nonalcoholics.+A+clinical+and+histologic+comparison+with+alcohol-induced+liver+injury.&rft.au=Diehl%2C+A+M%3BGoodman%2C+Z%3BIshak%2C+K+G&rft.aulast=Diehl&rft.aufirst=A&rft.date=1988-10-01&rft.volume=95&rft.issue=4&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-07 N1 - Date created - 1988-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Maleic vinyl ether anhydride nephropathy: altered glomerular permeability due to an immunomodulating agent. AN - 78377720; 2842098 AB - The polyanionic immunomodulatory polymer, maleic vinyl ether anhydride (MVE-2), enhances antitumor macrophage activity and causes heavy proteinuria. The effects of this compound on renal function and renal morphology were investigated in a rat model. Rats were given daily intravenous infusions of MVE-2, 100 mg/kg, over 2-4 hr on each of three consecutive days. Renal function and morphology in MVE-2-infused rats were examined by standard techniques and compared to control rats given saline. On the average, MVE-2 rats had a significant reduction in inulin clearance to 62% of control values. MVE-2 rats developed heavy proteinuria 1-3 days after the first infusion (mean +/- 1 SEM, 387 +/- 91 mg/24 hr). By light microscopy, the only finding was intratubular protein casts; glomeruli were normal. Immunofluorescence showed no deposition of antibody, complement, or fibrin. Electron microscopy revealed foot process effacement, epithelial cell vacuolization, and subepithelial ring-shaped structures; no immune-complex deposits were present. MVE-2 rats had no increase in the number of glomerular Ia(+) cells. To examine further the mechanism of MVE-2 nephropathy, the ability of MVE-2 to induce proteinuria in animals pretreated with radiation (750 rad), methylprednisolone (MP) or cyclosporine (CyA) was determined. Animals pretreated with radiation or MP had significantly less proteinuria after MVE-2 treatment compared to animals receiving no immunosuppressive therapy, while CyA pretreated rats developed heavy proteinuria. These results are compatible with the hypothesis that MVE-2 induces proteinuria via an effect on steroid- and radiation-sensitive cells, perhaps related to production of circulating factors which alter glomerular permeability. JF - Clinical immunology and immunopathology AU - Bertolatus, J A AD - Department of Internal Medicine, University of Iowa College of Medicine, Veterans Administration Medical Center, Iowa City 52240. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 6 EP - 18 VL - 49 IS - 1 SN - 0090-1229, 0090-1229 KW - Histocompatibility Antigens Class II KW - 0 KW - Polymers KW - Pyran Copolymer KW - 27100-68-1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Kidney Glomerulus -- drug effects KW - Disease Models, Animal KW - Histocompatibility Antigens Class II -- analysis KW - Kidney Glomerulus -- pathology KW - Male KW - Pyran Copolymer -- toxicity KW - Polymers -- adverse effects KW - Kidney Diseases -- immunology KW - Pyran Copolymer -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78377720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+immunology+and+immunopathology&rft.atitle=Maleic+vinyl+ether+anhydride+nephropathy%3A+altered+glomerular+permeability+due+to+an+immunomodulating+agent.&rft.au=Bertolatus%2C+J+A&rft.aulast=Bertolatus&rft.aufirst=J&rft.date=1988-10-01&rft.volume=49&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Clinical+immunology+and+immunopathology&rft.issn=00901229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-13 N1 - Date created - 1988-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Social Supports in Relation to Physical Health and Symptoms of Depression in the Elderly AN - 61471273; 198900889 AB - In an interview/questionnaire study of the relationship of social supports to physical & psychological well-being in a sample of 118 Ms & Fs aged 65+ who were living independently in the San Diego, Calif, community, Ss with more symptoms of depression reported having less emotionally satisfying consistent support from relatives, but those with physical illnesses reported more support. It is concluded that although having fewer key supports may contribute to dysphoria, having a physical illness may mobilize meaningful support. Social support & health outcomes should be carefully defined so that possible differential relationships between them can be understood more specifically. 3 Tables, 33 References. Modified HA JF - The American Journal of Psychiatry AU - Grant, Igor AU - Patterson, Thomas L AU - Yager, Joel AD - Psychiatry Service Veterans Administration Medical Center, San Diego CA 92161 Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 1254 EP - 1258 VL - 145 IS - 10 SN - 0002-953X, 0002-953X KW - physical/psychological well being, elderly KW - social supports KW - interview/questionnaire data KW - San Diego, California KW - Depression (Psychology) KW - Well Being KW - Elderly KW - Social Support KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61471273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Social+Supports+in+Relation+to+Physical+Health+and+Symptoms+of+Depression+in+the+Elderly&rft.au=Grant%2C+Igor%3BPatterson%2C+Thomas+L%3BYager%2C+Joel&rft.aulast=Grant&rft.aufirst=Igor&rft.date=1988-10-01&rft.volume=145&rft.issue=10&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Well Being; Social Support; Depression (Psychology); San Diego, California ER - TY - JOUR T1 - Transcriptional regulation of the leukocyte adherence protein beta subunit during human myeloid cell differentiation. AN - 78425269; 2901419 AB - Adherence reactions involving human leukocytes are mediated by a family of glycoprotein surface antigens composed of three different alpha subunits designated alpha L, alpha M, and alpha X, each of which is associated with a single beta subunit in an alpha 1 beta 1 heterodimer structure. We cloned the cDNA for the common beta subunit and investigated beta subunit mRNA expression in HL-60 promyelocytic leukemia cells and human granulocytic cells. Leukocyte adherence receptor beta subunit mRNA transcripts were present in low levels in HL-60 myeloblasts and promyelocytes and increased 10-fold or greater with chemically induced differentiation to more mature granulocytes (using retinoic acid and dimethylformamide) or monocyte/macrophages (using phorbol myristate acetate). Levels of beta subunit mRNA expression were also increased both in normal human peripheral blood granulocytes and in granulocytes from patients with chronic myelogenous leukemia. Nuclear run-off assays indicated that the increased steady state level of the beta subunit mRNA in retinoic acid-differentiated HL-60 cells was secondary to enhanced beta subunit gene transcription. We conclude that mRNA levels for the beta subunit of the receptor on human leukocytes that mediates cellular adherence are increased in more mature granulocytic cells compared to immature myeloid precursors and that this enhanced mRNA expression is transcriptionally regulated. JF - The Journal of biological chemistry AU - Hickstein, D D AU - Hickey, M J AU - Collins, S J AD - Medical Research Division, Seattle Veterans Administration Medical Center, Washington 98108. Y1 - 1988/09/25/ PY - 1988 DA - 1988 Sep 25 SP - 13863 EP - 13867 VL - 263 IS - 27 SN - 0021-9258, 0021-9258 KW - Antigens, CD18 KW - 0 KW - Macromolecular Substances KW - Membrane Glycoproteins KW - RNA, Messenger KW - Tretinoin KW - 5688UTC01R KW - Dimethylformamide KW - 8696NH0Y2X KW - DNA KW - 9007-49-2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tretinoin -- pharmacology KW - Dimethylformamide -- pharmacology KW - Humans KW - Nucleic Acid Hybridization KW - RNA, Messenger -- genetics KW - Cloning, Molecular KW - Tumor Cells, Cultured KW - DNA -- genetics KW - Leukemia, Myeloid -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Differentiation -- drug effects KW - Cell Adhesion KW - Granulocytes -- metabolism KW - Transcription, Genetic KW - Gene Expression Regulation KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78425269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Transcriptional+regulation+of+the+leukocyte+adherence+protein+beta+subunit+during+human+myeloid+cell+differentiation.&rft.au=Hickstein%2C+D+D%3BHickey%2C+M+J%3BCollins%2C+S+J&rft.aulast=Hickstein&rft.aufirst=D&rft.date=1988-09-25&rft.volume=263&rft.issue=27&rft.spage=13863&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-19 N1 - Date created - 1988-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations and recovery of dendritic spine density in rat hippocampus following long-term ethanol ingestion. AN - 78487707; 3179712 AB - Neuronal loss and dendritic pathology are often observed in humans and animals after long-term ethanol ingestion. It is not known, however, if surviving but damaged neurons can recover normal structure during ethanol abstinence. We quantified dendritic spine density in two neuronal populations in rat hippocampus to investigate whether reversibility from the cellular neurotoxic sequelae of chronic ethanol exposure was possible. Male Long-Evans rats were maintained for 20 weeks on an ethanol-containing liquid diet. Controls were pair-fed a liquid diet with sucrose substituted isocalorically for ethanol. One-half of each group was sacrificed at the end of the 20-week treatment and one-half was given a 20-week ethanol-free recovery period period to sacrifice. Analysis of rapid Golgi material revealed a decreased spine density in CA1 pyramidal cells that increased to control level during abstinence, and an increased spine density in dentate gyrus granule cells that was reduced toward control level during abstinence. Thus, despite the fact that chronic ethanol exposure produced differential initial effects, the return toward normal spine density in each region is consistent with the concept of neuronal recovery and reorganization during abstinence from ethanol. JF - Brain research AU - King, M A AU - Hunter, B E AU - Walker, D W AD - Gainesville Veterans Administration Medical Center, FL. Y1 - 1988/09/06/ PY - 1988 DA - 1988 Sep 06 SP - 381 EP - 385 VL - 459 IS - 2 SN - 0006-8993, 0006-8993 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Time Factors KW - Male KW - Alcoholism -- pathology KW - Ethanol -- administration & dosage KW - Neuronal Plasticity -- drug effects KW - Hippocampus -- physiopathology KW - Dendrites -- physiology KW - Hippocampus -- pathology KW - Alcoholism -- physiopathology KW - Dendrites -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78487707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Alterations+and+recovery+of+dendritic+spine+density+in+rat+hippocampus+following+long-term+ethanol+ingestion.&rft.au=King%2C+M+A%3BHunter%2C+B+E%3BWalker%2C+D+W&rft.aulast=King&rft.aufirst=M&rft.date=1988-09-06&rft.volume=459&rft.issue=2&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-28 N1 - Date created - 1988-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Asymptomatic peptic disease in patients undergoing major elective operations: a prospective endoscopic study. AN - 85224936; pmid-3261936 AB - Postoperative bleeding is usually attributed to stress ulcers; however, occult preoperative lesions could also be responsible. To determine their frequency and nature, we prospectively examined 72 patients endoscopically prior to major elective operations. Entry criteria included a planned stay in the Surgical Intensive Care Unit, greater than 2 days, and a negative history, physical examination, and stool guaiac. Gastric and duodenal mucosae were scored separately, using a 0- to 7-point scale. Scores were graded negative (0), hyperemia (1), gastroduodenitis (2-5), mucosal erosions (6), and ulcers (7). Erosions or ulcers were found in 14% of patients and gastroduodenitis is an additional 10%. We found that none of the 27 risk factors or any combination of factors tested correlated with ulcers, erosions, or gastroduodenitis. Thus, patients with asymptomatic gastroduodenal erosions or ulcerations could not be identified preoperatively, except by endoscopy. Until the significance of these lesions as cause of postoperative bleeding is determined, we recommend routine postoperative gastric pH titration with antacids for patients undergoing major elective operations. JF - The American Journal of Gastroenterology AU - Rypins, E B AU - Sarfeh, I J AU - Collins-Irby, D AU - Stemmer, E A AU - Juler, G L AU - Thrower, S AD - Surgical Service, Long Beach Veterans Administration Medical Center, California. PY - 1988 SP - 927 EP - 929 VL - 83 IS - 9 SN - 0002-9270, 0002-9270 KW - Preoperative Care KW - Gastroscopy KW - Prospective Studies KW - Postoperative Complications KW - Human KW - Risk Factors KW - Stress, Psychological KW - Gastrointestinal Hemorrhage KW - Middle Age KW - Peptic Ulcer KW - Surgical Procedures, Operative UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85224936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Asymptomatic+peptic+disease+in+patients+undergoing+major+elective+operations%3A+a+prospective+endoscopic+study.&rft.au=Rypins%2C+E+B%3BSarfeh%2C+I+J%3BCollins-Irby%2C+D%3BStemmer%2C+E+A%3BJuler%2C+G+L%3BThrower%2C+S&rft.aulast=Rypins&rft.aufirst=E&rft.date=1988-09-01&rft.volume=83&rft.issue=9&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Possible linkage between alcoholism and esterase-D. AN - 78633806; 3216652 AB - Association and linkage relationships between alcoholism and 30 polymorphic marker loci were studied in a total of 42 families: 27 families originally collected as part of a study on depression spectrum disease, 14 previously reported families with depression spectrum disease, and 1 family with familial alcoholism. Since heterogeneity within a sample can confound genetic linkage analysis, obscuring linkage relationships, alcoholism was studied in these families as a disorder unrelated to depression or antisocial personality. No allelic associations were found to be significant after allowing for the multiple tests. In a sib-pair linkage analysis, significant differences between the mean proportion of genes identical by descent in concordant and discordant sib pairs were found for the esterase-D (ESD) marker locus (p less than or equal to .01). This suggested that a linkage may exist between a gene for alcoholism and the ESD locus on chromosome 13q. Lod score linkage analysis yielded odds in favor of linkage to ESD of 44 to 1, most of the information relevant to linkage residing in a single family in which three offspring were classified as alcoholic and five were not. JF - Journal of studies on alcohol AU - Tanna, V L AU - Wilson, A F AU - Winokur, G AU - Elston, R C AD - Veterans Administration Medical Center, Northport, New York 11768. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 472 EP - 476 VL - 49 IS - 5 SN - 0096-882X, 0096-882X KW - Genetic Markers KW - 0 KW - Carboxylic Ester Hydrolases KW - EC 3.1.1.- KW - Carboxylesterase KW - EC 3.1.1.1 KW - ESD protein, human KW - Index Medicus KW - Humans KW - Adult KW - Depressive Disorder -- genetics KW - Chromosomes, Human, Pair 13 KW - Male KW - Female KW - Genetic Linkage KW - Carboxylic Ester Hydrolases -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78633806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Possible+linkage+between+alcoholism+and+esterase-D.&rft.au=Tanna%2C+V+L%3BWilson%2C+A+F%3BWinokur%2C+G%3BElston%2C+R+C&rft.aulast=Tanna&rft.aufirst=V&rft.date=1988-09-01&rft.volume=49&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The stability of coexisting psychiatric syndromes in alcoholic men after one year. AN - 78633694; 3270510 AB - Alcoholic men (N = 241) were administered a criterion-referenced, structured, DSM-III compatible, diagnostic interview while hospitalized and again 1 year later as outpatients. This interview independently evaluates the lifetime prevalence of 15 major psychiatric disorders. In addition to alcoholism, the most frequently occurring coexisting disorders were depression, antisocial personality and drug abuse. After 1 year, the number of positive syndromes declined slightly (chi = 2.0 to 1.8). However, the absolute and relative number of additional psychiatric syndromes remained stable over 1 year for the entire sample. Across individuals, the overall rates of agreement for the 15 syndromes ranged from a high of 100% to a low of 85%. Similarly, the agreement for the current and lifetime diagnoses ranged from 86 to 99%. These data indicate that a substantial portion of male alcoholics experience symptoms that are common to other psychiatric disorders. They also suggest that the endorsement of multiple psychiatric symptoms is not due simply to the acute emotional and physical distress that often accompanies a recent hospitalization for alcoholism treatment. Instead, for many male alcoholics, the symptom patterns appear to reflect additional psychiatric disorders that are stable over time and a potential target of treatment. JF - Journal of studies on alcohol AU - Penick, E C AU - Powell, B J AU - Liskow, B I AU - Jackson, J O AU - Nickel, E J AD - Veterans Administration Medical Center, Kansas City, Missouri 64128. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 395 EP - 405 VL - 49 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Syndrome KW - Humans KW - Adult KW - Aged KW - Psychiatric Department, Hospital KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Manuals as Topic KW - Alcoholism -- rehabilitation KW - Mental Disorders -- diagnosis KW - Mental Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78633694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=The+stability+of+coexisting+psychiatric+syndromes+in+alcoholic+men+after+one+year.&rft.au=Penick%2C+E+C%3BPowell%2C+B+J%3BLiskow%2C+B+I%3BJackson%2C+J+O%3BNickel%2C+E+J&rft.aulast=Penick&rft.aufirst=E&rft.date=1988-09-01&rft.volume=49&rft.issue=5&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Stud Alcohol. 1989 Sep;50(5):491-2 [2779254] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes in depression among abstinent alcoholics. AN - 78632473; 3216643 AB - The rate and pattern of change in depressive symptoms among male primary alcoholics (no preexisting major psychiatric disorder) were studied throughout inpatient treatment for alcoholism. A sample of 191 alcoholics was interviewed with the Hamilton Depression Rating Scale within 48 hours of admission and again at each of the 4 weeks of treatment. Results indicate that 42% of alcoholics have clinically significant levels of depression (Hamilton greater than or equal to 20) at intake but only 6% remain clinically depressed at Week 4. Depressive symptoms of alcoholics abate quickly with the largest reduction in scores at Week 2. Mood related symptoms constitute the largest portion of presenting depression and abate most rapidly. Vegetative symptoms remain the most prevalent type of depressive symptom at discharge. Results suggest that antidepressant medication should not be considered prior to 4 weeks of abstinence. JF - Journal of studies on alcohol AU - Brown, S A AU - Schuckit, M A AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 412 EP - 417 VL - 49 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Psychological Tests KW - Alcoholism -- rehabilitation KW - Depressive Disorder -- psychology KW - Temperance KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78632473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Changes+in+depression+among+abstinent+alcoholics.&rft.au=Brown%2C+S+A%3BSchuckit%2C+M+A&rft.aulast=Brown&rft.aufirst=S&rft.date=1988-09-01&rft.volume=49&rft.issue=5&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Memory impairment in amnesia and dementia: implications for the use of animal models. AN - 78598789; 3062457 AB - Cases of amnesia, in which there is a stable memory impairment with sparing of other cognitive functions, have taught us a great deal about the neuroanatomic basis of memory storage and retrieval; animal models of amnesia have provided even more precise information about the brain mechanisms responsible for specific aspects of memory functioning. Amnestic syndromes are rare, however, and constitute only a tiny fraction of the clinical cases in which memory is impaired. Dementia, particularly that due to Alzheimer's disease, is much more common but differs from the amnestic syndromes in three important ways: (1) a variety of of cognitive functions including language and praxis are affected, (2) the condition is usually progressive with gradual loss of several neuronal populations, and (3) the etiology of dementia is not well understood at present but clinical data suggest some role for genetic, viral, vascular and toxic environmental factors. It is argued that animal models should give greater attention to these important features of the common clinical dementias. JF - Neurobiology of aging AU - Mohs, R C AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, NY 10468. PY - 1988 SP - 465 EP - 468 VL - 9 IS - 5-6 SN - 0197-4580, 0197-4580 KW - Index Medicus KW - Animals KW - Humans KW - Memory Disorders -- physiopathology KW - Amnesia -- physiopathology KW - Memory Disorders -- etiology KW - Dementia -- complications KW - Disease Models, Animal KW - Dementia -- physiopathology KW - Amnesia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78598789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=Memory+impairment+in+amnesia+and+dementia%3A+implications+for+the+use+of+animal+models.&rft.au=Mohs%2C+R+C&rft.aulast=Mohs&rft.aufirst=R&rft.date=1988-09-01&rft.volume=9&rft.issue=5-6&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=01974580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cellular influx and activation increase macrophage cytotoxicity and interleukin-1 elaboration during pulmonary inflammation in rats. AN - 78578930; 2974260 AB - This study was undertaken to investigate the effects of pulmonary inflammation induced by bacillus Calmette-Guérin (BCG) on the density distribution of lavaged alveolar macrophages. We sought to determine macrophage cytotoxicity and interleukin-1 elaboration in density-defined subpopulations of macrophages during tissue inflammation. At all time points after intravenously administered BCG, lavaged alveolar macrophages contained increased percentages of higher density cells. Alveolar macrophage cytotoxicity against the rat sarcoma cell line XC increased maximally 2 to 6 days after intravenous administration of BCG before declining on Day 13. Macrophage interleukin-1 elaboration increased maximally 14 days after administration of BCG before declining on Day 23. Additionally, macrophage cytotoxicity and interleukin-1 elaboration were increased above normal in cells from each of five density fractions. We conclude that a subpopulation of higher density macrophages, probably recently derived from blood monocytes, accumulates in inflammatory sites. Cellular activation increases the cytotoxicity and interleukin-1 elaboration by macrophages in all density-defined subpopulations and obscures the relationship between cellular density and function that is present in normal animals. JF - The American review of respiratory disease AU - Fuchs, H J AU - Sniezek, M AU - Shellito, J E AD - Respiratory Care Section, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 572 EP - 577 VL - 138 IS - 3 SN - 0003-0805, 0003-0805 KW - Interleukin-1 KW - 0 KW - Interleukin-2 KW - Abridged Index Medicus KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Rats KW - Bronchoalveolar Lavage Fluid -- immunology KW - Animals KW - Rats, Inbred F344 KW - Interleukin-2 -- analysis KW - Mycobacterium bovis -- pathogenicity KW - Pulmonary Alveoli -- immunology KW - Cytotoxicity Tests, Immunologic KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Cytotoxicity, Immunologic KW - Pneumonia -- immunology KW - Macrophages -- immunology KW - Interleukin-1 -- immunology KW - Macrophage Activation KW - Interleukin-1 -- analysis KW - Pneumonia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78578930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Cellular+influx+and+activation+increase+macrophage+cytotoxicity+and+interleukin-1+elaboration+during+pulmonary+inflammation+in+rats.&rft.au=Fuchs%2C+H+J%3BSniezek%2C+M%3BShellito%2C+J+E&rft.aulast=Fuchs&rft.aufirst=H&rft.date=1988-09-01&rft.volume=138&rft.issue=3&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-24 N1 - Date created - 1989-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interpersonal style differences among drug abusers. AN - 78538162; 3192724 AB - Interpersonal style differences among drug abusers were explored using Ryan's (1977) typological system of FIRO-B interpretation. One hundred eleven male veteran drug abusers were administered the FIRO-B, along with a battery of psychological tests and a structured interview. The drug abusers were more likely to be categorized as "loners," "rebels," and "pessimists" than was the general population sample. The categories within each FIRO-B dimension (inclusion, control, and affection) were collapsed into three larger subtypes based on general patterns of "expressed" and "wanted" scores within each dimension. The construct validity of the Ryan schema was tested by comparing the three larger groups for each dimension on a series of preselected variables for which differences would be hypothesized from FIRO theory. The results of these analyses were consistent with Ryan's (1977) and Schutz's (1978) theories about interpersonal orientation. The findings of the study provide information about the commonality and heterogeneity of interpersonal style among drug abusers. The findings also support the construct validity of Ryan's typological schema for the FIRO-B. JF - Journal of clinical psychology AU - Calsyn, D A AU - Roszell, D K AU - Anderson, L S AD - Seattle Veterans Administration Medical Center, Washington. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 821 EP - 830 VL - 44 IS - 5 SN - 0021-9762, 0021-9762 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Social Adjustment KW - Humans KW - MMPI KW - Adult KW - Social Isolation KW - Psychometrics KW - Male KW - Personality Tests KW - Interpersonal Relations KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78538162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Interpersonal+style+differences+among+drug+abusers.&rft.au=Calsyn%2C+D+A%3BRoszell%2C+D+K%3BAnderson%2C+L+S&rft.aulast=Calsyn&rft.aufirst=D&rft.date=1988-09-01&rft.volume=44&rft.issue=5&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-12 N1 - Date created - 1989-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic primidone treatment in the rat: an animal model of primidone therapy. AN - 78532906; 3187199 AB - A continuously protective, nontoxic, oral model of chronic treatment with primidone was developed in the rat. Rats were treated with primidone (100 mg/kg) by gastric gavage twice daily for up to 8 weeks. This treatment was continuously protective as measured by seizures induced by hexafluorodiethyl ether and minimally toxic as measured by weight gain. Plasma primidone concentration reached a peak (13 micrograms/ml) 2 hours after gavage and was almost undetectable by 12 hours. Plasma phenobarbital concentration peaked (52 micrograms/ml) at 6 hours postgavage after reaching a minimum (19 micrograms/ml) at one hour postgavage. Phenobarbital concentrations measured in plasma, brain and liver after 8 weeks of chronic treatment correlated significantly between each tissue and plasma. JF - Research communications in chemical pathology and pharmacology AU - Carl, G F AU - Smith, M L AD - Medical Research Service, Veterans Administration Medical Center, Augusta, Georgia 30910. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 365 EP - 376 VL - 61 IS - 3 SN - 0034-5164, 0034-5164 KW - Primidone KW - 13AFD7670Q KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Administration, Oral KW - Animals KW - Phenobarbital -- pharmacokinetics KW - Tissue Distribution KW - Seizures -- prevention & control KW - Time Factors KW - Models, Biological KW - Male KW - Primidone -- pharmacokinetics KW - Primidone -- therapeutic use KW - Primidone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78532906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Chronic+primidone+treatment+in+the+rat%3A+an+animal+model+of+primidone+therapy.&rft.au=Carl%2C+G+F%3BSmith%2C+M+L&rft.aulast=Carl&rft.aufirst=G&rft.date=1988-09-01&rft.volume=61&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-22 N1 - Date created - 1988-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary infiltrates associated with noncytotoxic drugs. AN - 78530652; 3055114 AB - A wide variety of noncytotoxic drugs, including antibiotics, analgesics, narcotics, and psychotrophic and cardiovascular agents, may cause lung injury accompanied by roentgenographic infiltrates. The clinical manifestations of drug-induced lung disease are protean. Patients may present with acute injury resembling the adult respiratory distress syndrome, which must initially be distinguished from bacterial sepsis. Other drug-associated lung injury is characterized by a more subacute pneumonitis similar to an atypical infectious pneumonia. Finally, some drugs may cause insidiously progressive pulmonary infiltrates that share features with granulomatous infections. The more common drug reactions are discussed in this review, and, although the features of drug-induced lung disease are often relatively nonspecific, those features that either mimic infectious causes or may be helpful in differentiating these processes from infections are given particular emphasis. JF - Seminars in respiratory infections AU - Rice, K L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 229 EP - 239 VL - 3 IS - 3 SN - 0882-0546, 0882-0546 KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Respiratory Tract Diseases -- diagnosis KW - Pulmonary Edema -- chemically induced KW - Respiratory Distress Syndrome, Adult -- chemically induced KW - Lung Diseases -- diagnosis KW - Lung Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78530652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+infections&rft.atitle=Pulmonary+infiltrates+associated+with+noncytotoxic+drugs.&rft.au=Rice%2C+K+L&rft.aulast=Rice&rft.aufirst=K&rft.date=1988-09-01&rft.volume=3&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+infections&rft.issn=08820546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-22 N1 - Date created - 1988-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary insults due to transfusions, radiation, and hyperoxia. AN - 78524061; 3055115 AB - Pulmonary insults caused by transfusion, radiation, and hyperoxia share many clinical features with insults caused by serious pulmonary infections. The major objective in evaluating these patients is to establish the diagnosis with as much certainty as possible. Unfortunately, there are no clinical aspects or laboratory tests that are pathognomonic for these diseases; therefore, it is often necessary to rely on a knowledge of those features which help to distinguish these disorders from infectious etiologies. For example, patients suffering from transfusion-related acute lung injury (TRALI) experience onset of insult within 6 hours of a transfusion and have the presence of leukoagglutinins in their serum. Patients with radiation injuries frequently have roentgenographic infiltrates that conform to the ports of radiation. Despite extensive animal and human studies, factors distinguishing hyperoxic injury from infectious disorders remain poorly defined. These clinical features and others are reviewed to identify the essential components in the diagnosis of TRALI, acute radiation pneumonitis, and hyperoxic pneumonitis. JF - Seminars in respiratory infections AU - Duane, P AD - Pulmonary Department, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 240 EP - 246 VL - 3 IS - 3 SN - 0882-0546, 0882-0546 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Diagnosis, Differential KW - Humans KW - Respiratory Tract Infections -- diagnosis KW - Lung Diseases -- etiology KW - Lung Diseases -- diagnosis KW - Blood Transfusion -- adverse effects KW - Oxygen -- adverse effects KW - Radiation Injuries -- etiology KW - Lung -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78524061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+infections&rft.atitle=Pulmonary+insults+due+to+transfusions%2C+radiation%2C+and+hyperoxia.&rft.au=Duane%2C+P&rft.aulast=Duane&rft.aufirst=P&rft.date=1988-09-01&rft.volume=3&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+infections&rft.issn=08820546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-22 N1 - Date created - 1988-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Digitalis. An update of clinical pharmacokinetics, therapeutic monitoring techniques and treatment recommendations. AN - 78491894; 3052985 AB - The intestinal absorption of digoxin is essentially a passive non-saturable diffusion process, although a saturable carrier-mediated component also plays an important role. The bioavailability varies between 40 and 100%: the presence of food may reduce the peak serum concentration, but does not reduce the amount of digoxin absorbed. Recent development of a capsule containing a hydroalcoholic vehicle may reduce interindividual variations in absorption. Pharmacokinetic analysis of the distribution of digoxin suggests 3 compartments, the slow distribution phase accounting for the lag time between the inotropic effects and the plasma concentration profile. Digoxin is extensively bound to tissues such as myocardium, renal, skeletal muscle as well as red blood cells, but not to adipose tissue. Plasma protein binding varies between 20 and 30%: displacement of digoxin from protein binding sites does not cause significant clinical effects. As expected, haemodialysis or exchange transfusions do not significantly alter the body load of digoxin. The apparent volume of distribution of digoxin varies between 5 and 7.3 L/kg; this may be reduced by, for example, electrolyte abnormalities which reduce digoxin binding to the myocardium. The elimination half-life of digoxin is 36 hours, with 60 to 80% being excreted unchanged, by passive glomerular filtration and active tubular secretion. The remainder is excreted non-renally. Clearance is therefore dependent on renal function and declines in renal disease and in elderly patients. Digoxin interacts with other drugs at any stage of absorption (e.g. cholestyramine), distribution (e.g. quinidine), metabolism (e.g. phenytoin) or elimination (e.g. diltiazem). Patients should, therefore, be carefully monitored when changing a therapeutic regimen which includes any drugs known to interact with digoxin. Clinical monitoring is more important than therapeutic drug monitoring which should be reserved for suspected toxicity, doubts about efficacy, or in cases of poor compliance. With the advent of newer treatment modalities, digoxin is no longer the treatment of first choice in supraventricular arrhythmias and congestive heart failure. However, with careful monitoring, digoxin remains an important therapeutic option. JF - Clinical pharmacokinetics AU - Mooradian, A D AD - Geriatric Research, Education and Clinical Center, Sepulveda Veterans Administration Medical Center, Los Angeles, California. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 165 EP - 179 VL - 15 IS - 3 SN - 0312-5963, 0312-5963 KW - Digitalis Glycosides KW - 0 KW - Index Medicus KW - Humans KW - Monitoring, Physiologic KW - Digitalis Glycosides -- therapeutic use KW - Digitalis Glycosides -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78491894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Digitalis.+An+update+of+clinical+pharmacokinetics%2C+therapeutic+monitoring+techniques+and+treatment+recommendations.&rft.au=Mooradian%2C+A+D&rft.aulast=Mooradian&rft.aufirst=A&rft.date=1988-09-01&rft.volume=15&rft.issue=3&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=03125963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-06 N1 - Date created - 1988-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of the anemia of predialysis patients with recombinant human erythropoietin: a randomized, placebo-controlled trial. AN - 78467831; 3177433 AB - Recombinant human erythropoietin (r-HuEPO) was administered in two phases to 12 patients with chronic renal insufficiency (creatinine clearances of 0.17-0.51 ml/second [10-30 ml/minute]) and uremic anemia. In addition to the routine tests done as part of a multicenter clinical trial, our patients had serial red cell mass measurements, quantitation of bone marrow stem cells, and marrow cytogenetic analysis. During the first eight weeks (acute phase), an equal number of patients was randomized to placebo or one of three doses of r-HuEPO (50, 100 or 150 unit/kg intravenously three times weekly). All three patients receiving 150 unit/kg responded by increasing their packed cell volume (PCV) to the normal range within eight weeks. There were lesser responses in PCV at the two lower doses of r-HuEPO and no response in the placebo group. The 51Cr red cell mass also increased significantly in a dose-related manner in patients receiving r-HuEPO but did not change in the placebo group. Marrow studies revealed increases in erythroid, megakaryocyte, and granulocyte-monocyte progenitor cells in those patients on r-HuEPO, but no mutagenic effects were seen. Subsequently, ten patients received open label r-HuEPO. During this maintenance phase, all ten achieved or maintained a normal PCV. Several adverse events occurred, but none were definitely linked to r-HuEPO. Recombinant human erythropoietin is an effective and potent treatment of anemia caused by renal failure. JF - The American journal of the medical sciences AU - Stone, W J AU - Graber, S E AU - Krantz, S B AU - Dessypris, E N AU - O'Neil, V L AU - Olsen, N J AU - Pincus, T P AD - Medical Service, Veterans Administration Medical Center, Nashville, TN 37212. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 171 EP - 179 VL - 296 IS - 3 SN - 0002-9629, 0002-9629 KW - Recombinant Proteins KW - 0 KW - Erythropoietin KW - 11096-26-7 KW - Abridged Index Medicus KW - Index Medicus KW - Bone Marrow -- pathology KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Random Allocation KW - Humans KW - Aged KW - Hematopoietic Stem Cells -- drug effects KW - Hematocrit KW - Middle Aged KW - Recombinant Proteins -- therapeutic use KW - Female KW - Kidney Failure, Chronic -- complications KW - Male KW - Erythropoietin -- therapeutic use KW - Anemia -- drug therapy KW - Anemia -- pathology KW - Anemia -- etiology KW - Erythropoietin -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78467831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Treatment+of+the+anemia+of+predialysis+patients+with+recombinant+human+erythropoietin%3A+a+randomized%2C+placebo-controlled+trial.&rft.au=Stone%2C+W+J%3BGraber%2C+S+E%3BKrantz%2C+S+B%3BDessypris%2C+E+N%3BO%27Neil%2C+V+L%3BOlsen%2C+N+J%3BPincus%2C+T+P&rft.aulast=Stone&rft.aufirst=W&rft.date=1988-09-01&rft.volume=296&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-18 N1 - Date created - 1988-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of urinary sediment by transmission electron microscopy. An innovative approach to diagnosis and prognosis in renal disease. AN - 78430840; 3168418 AB - Urinary sediment TEM is capable of unequivocally demonstrating renal tubule cells and distinguishing them from urinary tract epithelial cells. The renal tubule cells and the accompaniments including myeloid bodies, inflammatory cells, or fibrin permit, in a particular clinical setting, synthesis of a meaningful renal diagnosis. Sequential TEM sediment studies can clarify ambiguities in diagnosis. Precisely, when much difficulty is experienced in distinguishing ATN from aminoglycoside nephrotoxicity in a patient with sepsis who has received aminoglycoside, urinary sediment TEM can facilitate the differential diagnosis with confidence. In another clinical setting, such as hypersensitivity acute interstitial nephritis, TEM urinary sediment has an irrevocable place by exhibiting the characteristic eosinophil granules that will confirm the above diagnosis, or deny it when they are absent. The morphologic features in the renal tubule cells in the sediment reflect similar changes in the tubular cells in renal tissue. Therefore, the severity of tubular changes are commensurate with the clinical outcome in terms of renal function recovery, need of dialysis, and mortality. The degree of correlation is significant. Thus, slight or no TEM sediment tubular changes signifies a good prospect for renal function recovery and low or no mortality. Conversely, severe tubular changes in the TEM sediment denote persistent renal failure accompanied by high mortality. Furthermore, the most severe tubular changes, found in hepatorenal syndrome, are consistent with its dismal prognosis. JF - Clinics in laboratory medicine AU - Mandal, A K AD - Department of Medicine, Veterans Administration Medical Center, Dayton, Ohio. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 463 EP - 481 VL - 8 IS - 3 SN - 0272-2712, 0272-2712 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Index Medicus KW - Rats KW - Animals KW - Urine -- cytology KW - Kidney Tubular Necrosis, Acute -- urine KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Adult KW - Aged KW - Middle Aged KW - Microscopy, Electron KW - Male KW - Kidney Diseases -- urine KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78430840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+laboratory+medicine&rft.atitle=Analysis+of+urinary+sediment+by+transmission+electron+microscopy.+An+innovative+approach+to+diagnosis+and+prognosis+in+renal+disease.&rft.au=Mandal%2C+A+K&rft.aulast=Mandal&rft.aufirst=A&rft.date=1988-09-01&rft.volume=8&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Clinics+in+laboratory+medicine&rft.issn=02722712&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-07 N1 - Date created - 1988-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contribution of toxic oxygen intermediates to complement-induced reductions in effective hepatic blood flow. AN - 78428805; 2843655 AB - This study examines the effects of complement activation and of complement-induced oxygen radical production on the principal determinant of hepatic function, i.e., effective hepatic blood flow (EHBF). Female Sprague-Dawley rats received cobra venom factor, 40 units/kg, in two divided doses at 30-minute intervals. At t = 2 hours, thermodilution cardiac output, mean arterial pressure, heart rate, hematocrit, and EHBF by galactose clearance were determined. Complement activation produced a significant depression in EHBF independent of changes in systemic perfusion. To determine whether oxygen radicals participated in the insult, additional animals were pretreated with superoxide dismutase, 6 mg/kg, plus catalase, 15 mg/kg, immediately before complement activation. Concomitant treatment with the oxygen radical scavengers attenuated the degree of complement-induced hepatic ischemia, again independent of effects on systemic perfusion. This study suggests that the reduction in hepatic blood flow that accompanies animal models of trauma and sepsis may result, in part, from the sequelae of complement activation with oxygen radicals as secondary mediators. JF - The Journal of trauma AU - Schirmer, W J AU - Schirmer, J M AU - Naff, G B AU - Fry, D E AD - Department of Surgery, Veterans Administration Medical Center, Cleveland, OH 44106. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 1295 EP - 1300 VL - 28 IS - 9 SN - 0022-5282, 0022-5282 KW - Cobra Venoms KW - 0 KW - Free Radicals KW - Hydroxides KW - Superoxides KW - 11062-77-4 KW - Hydroxyl Radical KW - 3352-57-6 KW - Complement System Proteins KW - 9007-36-7 KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Superoxides -- metabolism KW - Superoxide Dismutase -- pharmacology KW - Cobra Venoms -- pharmacology KW - Complement Activation -- drug effects KW - Hydroxides -- metabolism KW - Catalase -- pharmacology KW - Female KW - Oxygen -- metabolism KW - Complement System Proteins -- physiology KW - Liver Circulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78428805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+trauma&rft.atitle=Contribution+of+toxic+oxygen+intermediates+to+complement-induced+reductions+in+effective+hepatic+blood+flow.&rft.au=Schirmer%2C+W+J%3BSchirmer%2C+J+M%3BNaff%2C+G+B%3BFry%2C+D+E&rft.aulast=Schirmer&rft.aufirst=W&rft.date=1988-09-01&rft.volume=28&rft.issue=9&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+trauma&rft.issn=00225282&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-17 N1 - Date created - 1988-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential effects of retinoids and chronic ethanol consumption on membranes in rats. AN - 78420707; 3418417 AB - Liver plasma membranes (LPM) were prepared from vitamin A-deficient and -sufficient rats as well as from animals treated with retinoic acid, with or without ethanol. Although the fluorescence polarization value of LPM prepared from retinoic acid-fed animals was significantly lower than that of controls (0.201 +/- 0.008 vs. 0.254 +/- 0.005, P less than 0.001), no effect was seen with a vitamin A-deficient diet (0.259 +/- 0.005). No change in the fluorescence polarization was observed in erythrocyte ghost membranes with either vitamin A deficiency or chronic ethanol consumption. The sialic acid concentration of the membranes was significantly higher in LPM and erythrocyte ghosts obtained from vitamin A-deficient animals (37.6 +/- 1.1 vs. 29.6 +/- 0.7 nmol/mg protein for LPM, P less than 0.01, and 77.7 +/- 0.6 vs. 62.0 +/- 1.7 for erythrocyte ghosts, P less than 0.001); the LPM of retinoic acid-treated animals had the lowest values (26.9 +/- 1.6 nmol/mg protein). This sialic acid concentration of LPM was positively correlated with the fluorescence polarization (r = 0.775, P less than 0.001). Chronic ethanol feeding resulted in lower hepatic and LPM vitamin A and greater LPM fluidity with higher cholesterol esters in all diet groups (P less than 0.001). Because increased sialic acid concentration has been incriminated in the pathogenesis of tumor development, it may provide a mechanism whereby lowered hepatic vitamin A promotes carcinogenesis and retinoic acid feeding opposes this process. JF - The Journal of nutrition AU - Kim, C I AU - Leo, M A AU - Lowe, N AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 1097 EP - 1103 VL - 118 IS - 9 SN - 0022-3166, 0022-3166 KW - Retinoids KW - 0 KW - Mannose KW - PHA4727WTP KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Fluorescence Polarization KW - Membrane Fluidity -- drug effects KW - Galactose -- metabolism KW - Erythrocyte Membrane -- drug effects KW - Mannose -- metabolism KW - Male KW - Erythrocyte Membrane -- metabolism KW - Vitamin A Deficiency -- metabolism KW - Liver -- drug effects KW - Cell Membrane -- drug effects KW - Liver -- metabolism KW - Alcoholism -- metabolism KW - Retinoids -- pharmacology KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78420707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Differential+effects+of+retinoids+and+chronic+ethanol+consumption+on+membranes+in+rats.&rft.au=Kim%2C+C+I%3BLeo%2C+M+A%3BLowe%2C+N%3BLieber%2C+C+S&rft.aulast=Kim&rft.aufirst=C&rft.date=1988-09-01&rft.volume=118&rft.issue=9&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-24 N1 - Date created - 1988-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hemodynamic and renal effects of atrial natriuretic factor in portal hypertensive rats. Potentiation by Phe-Ile-Orn-vasopressin. AN - 78420144; 2971104 AB - The effects of atrial natriuretic factor (ANF) on splanchnic hemodynamics and renal function in portal hypertensive models are described incompletely. Furthermore, ANF-induced vasodilatation and hypotension may limit the assessment of its own renal physiological effects. We infused ANF (human ANF 102-126) to anesthetized portal vein-ligated rats, a model with prehepatic portal hypertension. Arterial pressure was reduced by 17%, but portal pressure was unaffected. Diuresis and natriuresis were explained in part by an increase in glomerular filtration rate; in addition, renal vascular resistance was significantly decreased. The natriuretic response to ANF was slightly, but significantly, decreased in portal hypertensive rats as compared to controls (fractional excretion of sodium, 1.8 +/- 0.4 vs. 2.9 +/- 0.3; P less than .05). The addition of Phe-Ile-Orn-vasopressin, a V1 receptor agonist, normalized arterial pressure but induced a significant decrease in portal pressure (15 +/- 0.9 mm Hg base line vs. 12.8 +/- 0.7 combination group; P less than .01). Furthermore, the combination of both drugs markedly potentiated the natriuretic effects (0.4 +/- 0.1 microEq/min of control vs. 10.0 +/- 2.3 ANF vs. 32.2 +/- 3.3 combination group; P less than .001). The natriuretic potentiation resulted from increments in glomerular filtration rate and renal blood flow. Normalization of arterial pressure may enhance the renal physiological effects of ANF, in this portal hypertensive model. JF - The Journal of pharmacology and experimental therapeutics AU - Ganger, D R AU - Gottstein, J AU - Blei, A T AD - Department of Medicine, Veterans Administration Lakeside Medical Center, Chicago, Illinois. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 941 EP - 945 VL - 246 IS - 3 SN - 0022-3565, 0022-3565 KW - Vasopressins KW - 11000-17-2 KW - Ornipressin KW - 1KTH6N080W KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Hemodynamics -- drug effects KW - Natriuresis -- drug effects KW - Animals KW - Glomerular Filtration Rate -- drug effects KW - Drug Synergism KW - Male KW - Splanchnic Circulation -- drug effects KW - Ornipressin -- pharmacology KW - Kidney -- drug effects KW - Atrial Natriuretic Factor -- pharmacology KW - Ornipressin -- analogs & derivatives KW - Hypertension, Portal -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78420144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Hemodynamic+and+renal+effects+of+atrial+natriuretic+factor+in+portal+hypertensive+rats.+Potentiation+by+Phe-Ile-Orn-vasopressin.&rft.au=Ganger%2C+D+R%3BGottstein%2C+J%3BBlei%2C+A+T&rft.aulast=Ganger&rft.aufirst=D&rft.date=1988-09-01&rft.volume=246&rft.issue=3&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-21 N1 - Date created - 1988-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lipocytes and transitional cells in alcoholic liver disease: a morphometric study. AN - 78419415; 3417223 AB - Lipocytes and transitional cells in alcoholic liver disease were analyzed by quantitative morphometry in liver biopsy specimens of 17 alcoholic patients. In fatty livers, 93% of the perisinusoidal cells were lipocytes with a volume of lipid droplets occupying more than 20% of the individual cell volume. In fatty livers with perivenular fibrosis, 83% of the cells were lipocytes and 17% were transitional cells with lipid droplets of less than 20% of the cell volume. In cirrhosis, 45% of the cells were lipocytes and 55% of the cells were transitional cells. Thus, the process of hepatic fibrosis was associated with a shift from lipocytes to transitional cells. The percentage of transitional cells (expressed as total perisinusoidal cells) was 5.1% in fatty livers, 16.5% in fatty livers with perivenular fibrosis (not significantly different when compared to fatty livers) and 59.7% in cirrhotic livers (p less than 0.025) when compared to fatty livers or fatty livers with perivenular fibrosis). The number of transitional cells per 100 hepatocytes was estimated to be 0.5 in fatty livers, 1.3 in fatty livers with perivenular fibrosis and 2.1 in cirrhotic livers. The appearance of transitional cells was associated with a corresponding decrease in the number of lipocytes, supporting the hypothesis that transitional cells were derived from lipocytes. In comparison to lipocytes, the surface area of transitional cells (as measured by digitized morphometry) was 30 to 46% smaller (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Mak, K M AU - Lieber, C S AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York 10468. PY - 1988 SP - 1027 EP - 1033 VL - 8 IS - 5 SN - 0270-9139, 0270-9139 KW - Index Medicus KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Cell Count KW - Fatty Liver, Alcoholic -- metabolism KW - Fibrosis KW - Humans KW - Liver Cirrhosis, Alcoholic -- pathology KW - Biopsy KW - Hepatitis, Alcoholic -- pathology KW - Histocytochemistry KW - Fatty Liver, Alcoholic -- pathology KW - Microscopy, Electron KW - Hepatitis, Alcoholic -- metabolism KW - Male KW - Liver Diseases, Alcoholic -- metabolism KW - Liver -- pathology KW - Adipose Tissue -- metabolism KW - Liver Diseases, Alcoholic -- pathology KW - Liver -- metabolism KW - Adipose Tissue -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78419415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Lipocytes+and+transitional+cells+in+alcoholic+liver+disease%3A+a+morphometric+study.&rft.au=Mak%2C+K+M%3BLieber%2C+C+S&rft.aulast=Mak&rft.aufirst=K&rft.date=1988-09-01&rft.volume=8&rft.issue=5&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Penicillin anaphylaxis: fatality in elderly patients without a history of penicillin allergy. AN - 78418309; 3415739 AB - Two anaphylactic fatalities following penicillin administration are reported. Neither of the two patients had a history of previous penicillin allergy. Both were elderly and suffered from active cardiovascular disease. Penicillin skin testing may be indicated in some high-risk patients requiring parenteral penicillin, despite a negative history for penicillin allergy. JF - The American journal of emergency medicine AU - Sue, M A AU - Noritake, D T AU - Klaustermeyer, W B AD - Department of Medicine, Wadsworth Veterans Administration Medical Center, Los Angeles, CA 90073. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 456 EP - 458 VL - 6 IS - 5 SN - 0735-6757, 0735-6757 KW - Penicillin G KW - Q42T66VG0C KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Drug Hypersensitivity -- complications KW - Anaphylaxis -- chemically induced KW - Penicillin G -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78418309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+emergency+medicine&rft.atitle=Penicillin+anaphylaxis%3A+fatality+in+elderly+patients+without+a+history+of+penicillin+allergy.&rft.au=Sue%2C+M+A%3BNoritake%2C+D+T%3BKlaustermeyer%2C+W+B&rft.aulast=Sue&rft.aufirst=M&rft.date=1988-09-01&rft.volume=6&rft.issue=5&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+emergency+medicine&rft.issn=07356757&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-20 N1 - Date created - 1988-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Who should receive clozapine? AN - 78412462; 2901253 JF - Archives of general psychiatry AU - Marder, S R AU - Van Putten, T AD - West Los Angeles Veterans Administration Medical Center, Brentwood Division, CA 90073. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 865 EP - 867 VL - 45 IS - 9 SN - 0003-990X, 0003-990X KW - Antipsychotic Agents KW - 0 KW - Dibenzazepines KW - Clozapine KW - J60AR2IKIC KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Clinical Trials as Topic KW - Agranulocytosis -- chemically induced KW - Clozapine -- therapeutic use KW - Schizophrenia -- drug therapy KW - Clozapine -- adverse effects KW - Dibenzazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78412462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Who+should+receive+clozapine%3F&rft.au=Marder%2C+S+R%3BVan+Putten%2C+T&rft.aulast=Marder&rft.aufirst=S&rft.date=1988-09-01&rft.volume=45&rft.issue=9&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-06 N1 - Date created - 1988-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Gen Psychiatry. 1990 Feb;47(2):189-90 [1967927] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome. AN - 78400510; 3137819 JF - The American journal of medicine AU - Roberts, D E AU - Berman, S M AU - Nakasato, S AU - Wyle, F A AU - Wishnow, R M AU - Segal, G P AD - Medical Service, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 428 EP - 431 VL - 85 IS - 3 SN - 0002-9343, 0002-9343 KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Zidovudine KW - 4B9XT59T7S KW - Lithium KW - 9FN79X2M3F KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Neutrophils -- drug effects KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Leukocyte Count KW - Acquired Immunodeficiency Syndrome -- blood KW - Neutropenia -- chemically induced KW - Lithium -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Thymidine -- analogs & derivatives KW - Agranulocytosis -- chemically induced KW - Thymidine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78400510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Effect+of+lithium+carbonate+on+zidovudine-associated+neutropenia+in+the+acquired+immunodeficiency+syndrome.&rft.au=Roberts%2C+D+E%3BBerman%2C+S+M%3BNakasato%2C+S%3BWyle%2C+F+A%3BWishnow%2C+R+M%3BSegal%2C+G+P&rft.aulast=Roberts&rft.aufirst=D&rft.date=1988-09-01&rft.volume=85&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-03 N1 - Date created - 1988-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Med. 1989 Sep;87(3):362-3 [2505617] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal transplant obstruction by B cell lymphoproliferative disorder: case report and review of the literature. AN - 78394372; 2842516 AB - We report a case of renal transplant ureteral obstruction caused by a cyclosporine-associated B cell lymphoproliferative disorder. The interaction of cyclosporine with Epstein-Barr virus infections and the predisposition towards B cell lymphoproliferative disorders are reviewed. The characterization of these tumors by deoxyribonucleic acid hybridization studies and a review of the clinical experience treating these disorders also are presented. JF - The Journal of urology AU - Gibel, L J AU - Harford, A AU - Yogel, L R AU - Spiegel, J AU - Sterling, W AU - Tung, K AD - Department of Urology, Albuquerque Veterans Administration Hospital, New Mexico. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 593 EP - 595 VL - 140 IS - 3 SN - 0022-5347, 0022-5347 KW - Cyclosporins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Cyclosporins -- adverse effects KW - Humans KW - Middle Aged KW - Radiography KW - B-Lymphocytes KW - Herpesvirus 4, Human KW - Male KW - Tumor Virus Infections -- complications KW - Ureteral Neoplasms -- complications KW - Lymphoma -- etiology KW - Kidney Transplantation KW - Ureteral Neoplasms -- etiology KW - Ureteral Neoplasms -- pathology KW - Lymphoma -- complications KW - Ureteral Obstruction -- etiology KW - Lymphoma -- pathology KW - Ureteral Obstruction -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78394372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Renal+transplant+obstruction+by+B+cell+lymphoproliferative+disorder%3A+case+report+and+review+of+the+literature.&rft.au=Gibel%2C+L+J%3BHarford%2C+A%3BYogel%2C+L+R%3BSpiegel%2C+J%3BSterling%2C+W%3BTung%2C+K&rft.aulast=Gibel&rft.aufirst=L&rft.date=1988-09-01&rft.volume=140&rft.issue=3&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-28 N1 - Date created - 1988-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest. AN - 78394236; 2458026 AB - The efficacy and safety of sotalol were assessed by electrophysiologic testing and ambulatory recordings in 16 patients with recurrent sustained ventricular tachycardia (VT) or nonfatal cardiac arrest who were refractory to an average of 4.8 conventional antiarrhythmic agents. Twenty-four-hour ambulatory recordings were performed before and after sotalol therapy. Fourteen patients underwent baseline electrophysiologic study and sustained VT was inducible in 12. Oral sotalol (320 to 960 mg/day) completely suppressed inducible sustained VT in 7 patients (58%), with modification in 3 (25%). Ventricular premature complexes were suppressed from baseline (mean +/- standard deviation) 431 +/- 616 to 60 +/- 110/hr (p less than 0.03). After a mean follow-up of 19 +/- 7 months, 12 of 14 patients receiving sotalol treatment had successful suppression of ventricular premature complexes (60 +/- 85/hr) and remained clinically free of sustained VT, except 2 who needed additional antiarrhythmic drugs to suppress the recurrent sustained VT. One patient died suddenly after 25 months of sotalol treatment. No severe side effects were noted during sotalol therapy. This study demonstrates that sotalol is a well-tolerated, effective antiarrhythmic agent in patients at high-risk for sudden death. It appears to be beneficial in patients who did not benefit from multiple drug treatment. JF - The American journal of cardiology AU - Singh, S N AU - Cohen, A AU - Chen, Y W AU - Wish, M AU - Thoben-O'Grady, L AU - Peralba, J AU - Gottdiener, J AU - Fletcher, R D AD - Veterans Administration Medical Center, Cardiology Section, Washington, DC 20422. Y1 - 1988/09/01/ PY - 1988 DA - 1988 Sep 01 SP - 399 EP - 402 VL - 62 IS - 7 SN - 0002-9149, 0002-9149 KW - Sotalol KW - A6D97U294I KW - Abridged Index Medicus KW - Index Medicus KW - Cardiac Complexes, Premature -- etiology KW - Heart Rate KW - Cardiac Complexes, Premature -- physiopathology KW - Cardiac Complexes, Premature -- drug therapy KW - Humans KW - Electrocardiography KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Stroke Volume KW - Tachycardia -- complications KW - Heart Arrest -- drug therapy KW - Sotalol -- therapeutic use KW - Tachycardia -- drug therapy KW - Heart Arrest -- physiopathology KW - Tachycardia -- physiopathology KW - Heart Arrest -- complications KW - Sotalol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78394236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Sotalol+for+refractory+sustained+ventricular+tachycardia+and+nonfatal+cardiac+arrest.&rft.au=Singh%2C+S+N%3BCohen%2C+A%3BChen%2C+Y+W%3BWish%2C+M%3BThoben-O%27Grady%2C+L%3BPeralba%2C+J%3BGottdiener%2C+J%3BFletcher%2C+R+D&rft.aulast=Singh&rft.aufirst=S&rft.date=1988-09-01&rft.volume=62&rft.issue=7&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-30 N1 - Date created - 1988-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. AN - 78342823; 3135225 AB - Some, but not all, studies have suggested that high-fat diets promote colon carcinogenesis, possibly by stimulating the proliferative activity of colonic epithelium. Both the increase in colonic excretion of bile salts and of fatty acids that occur with an increase in fat ingestion have been implicated as stimuli of epithelial proliferative activity. In this study, we examined the role of activation of protein kinase C in fatty acid-induced stimulation of colonic epithelial proliferation in the rat. Intracolonic instillation of arachidonate, linoleate, or oleate at concentrations that did not induce surface cell injury or loss increased colonic mucosal ornithine decarboxylase activity and stimulated incorporation of [3H]thymidine into mucosal deoxyribonucleic acid. The saturated fatty acid palmitate was without effect. Arachidonate, linoleate, and oleate each induced the translocation of protein kinase C activity from the soluble fraction to the membrane fraction of colonic mucosa, an index of enzyme activation. The translocation of protein kinase C induced by unsaturated fatty acids occurred both in vivo after intracolonic instillation of these agents and in vitro upon incubation of isolated colonic crypt epithelium with fatty acids. The effects of the unsaturated fatty acids on both enzyme translocation and colonic epithelial proliferative activity were suppressed by 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C activity. Unsaturated fatty acids directly stimulated soluble colonic mucosal protein kinase C activity when added to the enzyme assay mixture. This action was blocked by 1-(5-isoquinolinyl)-2-methylpiperazine. However, unsaturated fatty acids also increased the breakdown of polyphosphoinositides when added to isolated colonic epithelium. The increase in polyphosphoinositide breakdown resulted in release of diacylglycerol, an endogenous activator of protein kinase C. Thus, unsaturated fatty acids may activate protein kinase C of colonic epithelium through either a direct intracellular effect or through an action on the cell membrane. The results support a role for protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. JF - Gastroenterology AU - Craven, P A AU - DeRubertis, F R AD - Department of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 676 EP - 685 VL - 95 IS - 3 SN - 0016-5085, 0016-5085 KW - Arachidonic Acids KW - 0 KW - Diglycerides KW - Fatty Acids, Unsaturated KW - Inositol Phosphates KW - Isoquinolines KW - Linoleic Acids KW - Oleic Acids KW - Palmitic Acids KW - Piperazines KW - Protein Kinase Inhibitors KW - Arachidonic Acid KW - 27YG812J1I KW - Oleic Acid KW - 2UMI9U37CP KW - Palmitic Acid KW - 2V16EO95H1 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - DNA KW - 9007-49-2 KW - Linoleic Acid KW - 9KJL21T0QJ KW - Protein Kinase C KW - EC 2.7.11.13 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - Oleic Acids -- pharmacology KW - Animals KW - Enzyme Activation KW - Inositol Phosphates -- metabolism KW - DNA -- metabolism KW - Piperazines -- pharmacology KW - Arachidonic Acids -- pharmacology KW - Thymidine -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Ornithine Decarboxylase -- metabolism KW - Isoquinolines -- pharmacology KW - Palmitic Acids -- pharmacology KW - Epithelial Cells KW - Linoleic Acids -- pharmacology KW - Female KW - Cell Division KW - Diglycerides -- metabolism KW - Protein Kinase C -- metabolism KW - Colon -- enzymology KW - Colon -- cytology KW - Fatty Acids, Unsaturated -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78342823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Role+of+activation+of+protein+kinase+C+in+the+stimulation+of+colonic+epithelial+proliferation+by+unsaturated+fatty+acids.&rft.au=Craven%2C+P+A%3BDeRubertis%2C+F+R&rft.aulast=Craven&rft.aufirst=P&rft.date=1988-09-01&rft.volume=95&rft.issue=3&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Laparotomy stimulates an endogenous gastric mucosal protective mechanism in the rat. A microcirculatory and morphologic study of ethanol injury. AN - 78342273; 3135224 AB - In vivo microscopy in the anesthetized rat unexpectedly revealed that the topical application of 75% ethanol to the gastric mucosa had no effect on the mucosal microcirculation. If, however, the synthesis of endogenous prostaglandin was inhibited by indomethacin, the topical application of 75% ethanol resulted in complete superficial mucosal microcirculatory stasis in the majority of rats. In indomethacin-pretreated rats, Rioprostil, a synthetic prostaglandin E1 analogue, reversed this effect of topical ethanol. The degree of ethanol-induced histologic gastric mucosal damage was inversely correlated with time to complete stasis. Ethanol injury studies under various conditions revealed that laparotomy stimulated a gastric protective mechanism that persisted for between 1 and 2 h and that was blocked by indomethacin. In conclusion, (a) laparotomy stimulates a gastric mucosal protective mechanism that probably is mediated by prostaglandin synthesis, and (b) cessation of mucosal blood flow appears to be an important early step in ethanol-induced gastric mucosal injury, and maintenance of mucosal blood flow by endogenous or exogenous prostaglandin may play a major role in prostaglandin protection. JF - Gastroenterology AU - Yonei, Y AU - Guth, P H AD - Medical and Research Service, Veterans Administration Medical Center, West Los Angeles, California. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 600 EP - 611 VL - 95 IS - 3 SN - 0016-5085, 0016-5085 KW - Prostaglandin Antagonists KW - 0 KW - Prostaglandins KW - Prostaglandins E KW - Ethanol KW - 3K9958V90M KW - Rioprostil KW - 7JL402PVQR KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Prostaglandins -- physiology KW - Animals KW - Microcirculation -- pathology KW - Prostaglandins E -- pharmacology KW - Microcirculation -- drug effects KW - Blood Flow Velocity -- drug effects KW - Prostaglandin Antagonists -- pharmacology KW - Male KW - Indomethacin -- pharmacology KW - Laparotomy KW - Gastric Mucosa -- blood supply KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78342273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Laparotomy+stimulates+an+endogenous+gastric+mucosal+protective+mechanism+in+the+rat.+A+microcirculatory+and+morphologic+study+of+ethanol+injury.&rft.au=Yonei%2C+Y%3BGuth%2C+P+H&rft.aulast=Yonei&rft.aufirst=Y&rft.date=1988-09-01&rft.volume=95&rft.issue=3&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 1990 Jan;98(1):249-50 [2293589] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytomatrix reorganization in dimethyl sulfoxide-induced "Qi" substate murine hepatic tumor cells. AN - 78359754; 3403070 AB - Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA content), enhanced production of liver-specific proteins, and decreased expression of growth traits characteristic of the transformed phenotype. Entrance of HT cells into Qi was associated with increased monolayer compaction and a shift from an elaborate surface fibronectin (FN) network to a sparse and restricted distribution of FN fibers. This marked decrease in the extent and complexity of the cellular FN network, as a consequence of DMSO exposure, was reflected in a 90% decline in the amount of FN secreted into the culture medium. These data complement previous studies indicating that the accumulation and composition of liver cell matrix substances reflect altered patterns of hepatocyte-specific gene expression. In the HT cell system, DMSO appears to act in a bifunctional manner, increasing the production of certain tissue-specific proteins (e.g., albumin and alpha-fetoprotein) while decreasing the secretion and deposition of other cellular components (FN). DMSO may directly regulate expression of these proteins in HT cells or alter the pattern of cellular response to specific autocrine growth factors. JF - International journal of cancer AU - Ryan, M P AU - Higgins, P J AD - Laboratory of Cell and Molecular Biology, Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1988/08/15/ PY - 1988 DA - 1988 Aug 15 SP - 273 EP - 278 VL - 42 IS - 2 SN - 0020-7136, 0020-7136 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Dose-Response Relationship, Drug KW - Mice KW - Flow Cytometry KW - Liver Neoplasms -- ultrastructure KW - Liver Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78359754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Cytomatrix+reorganization+in+dimethyl+sulfoxide-induced+%22Qi%22+substate+murine+hepatic+tumor+cells.&rft.au=Ryan%2C+M+P%3BHiggins%2C+P+J&rft.aulast=Ryan&rft.aufirst=M&rft.date=1988-08-15&rft.volume=42&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-14 N1 - Date created - 1988-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection of two different kanamycin resistance genes in naturally occurring isolates of Campylobacter jejuni and Campylobacter coli. AN - 85266877; pmid-3190204 AB - A total of 225 isolates of Campylobacter jejuni and 54 isolates of Campylobacter coli were screened for resistance to kanamycin. Among these, five resistant isolates of C. jejuni and six resistant isolates of C. coli, all with different plasmid patterns, were identified. Each contained at least one plasmid greater than or equal to 41 kilobases in size. The MIC of kanamycin for all 11 strains was determined to be greater than or equal to 256 micrograms/ml by an agar dilution method. In addition, all of the strains exhibited resistance to tetracycline (greater than or equal to 16 micrograms/ml). Eight of the 11 strains transferred the kanamycin resistance phenotype to other Campylobacter strains by conjugation. DNA from 9 of the 11 strains hybridized to a DNA probe specific for the 3'-O-aminoglycoside phosphotransferase type III gene. The remaining two strains also failed to show homology with DNA probes specific for the genes encoding 3'-O-aminoglycoside phosphotransferase types I, II, and III. The novel kanamycin resistance gene was cloned into the vector pBR322 and was expressed in Escherichia coli. Phosphocellulose paper binding assays on sonicates of the E. coli strain carrying the cloned kanamycin determinant demonstrated significant activity against kanamycin, neomycin, and amikacin but not against butirosin, gentamicin, tobramycin, or lividomycin, suggesting that the enzyme is the product of a 3'-O-aminoglycoside phosphotransferase type of aminoglycoside resistance gene. JF - Antimicrobial Agents and Chemotherapy AU - Tenover, F C AU - Elvrum, P M AD - Seattle Veterans Administration Medical Center, Washington 98108. PY - 1988 SP - 1170 EP - 1173 VL - 32 IS - 8 SN - 0066-4804, 0066-4804 KW - Genes, Bacterial KW - Blotting, Southern KW - Human KW - Conjugation, Genetic KW - Animal KW - Support, U.S. Gov't, Non-P.H.S. KW - Campylobacter KW - Kanamycin Resistance KW - Kanamycin KW - Nucleic Acid Hybridization KW - Cloning, Molecular KW - Campylobacter fetus KW - R Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85266877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Detection+of+two+different+kanamycin+resistance+genes+in+naturally+occurring+isolates+of+Campylobacter+jejuni+and+Campylobacter+coli.&rft.au=Tenover%2C+F+C%3BElvrum%2C+P+M&rft.aulast=Tenover&rft.aufirst=F&rft.date=1988-08-01&rft.volume=32&rft.issue=8&rft.spage=1170&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+and+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Righting the medical record. Transforming chronicle into story. AN - 85225277; pmid-3392815 AB - Narratives of illness in medical records and case presentations in teaching hospitals say surprisingly little about an important matter: what patients understand and feel. Nowadays, medical narratives tend to neglect or objectify subjective experience, including symptoms. Such narratives concentrate, in the manner of chronicles, on events in the exterior, objective world rather than the interior world of the sick. Medical students and physicians will construct more balanced accounts of human illness once they envision these accounts as "story", a form of narrative that traditionally accesses subjective experience as well as objective events. One can effectively begin the process of transforming medical chronicles into stories simply by asking patients what they know and how they feel about their situation and by documenting the response, using some of the patient's words, in the history of present illness. These actions will identify and preserve important information, facilitate empathy in all care givers who hear or read the history, and signal to everyone the physician's serious interest in patients as persons. Getting the voice of the patient into the history of present illness will not only help to right the medical record, but also help to right the relationship of physician and patient. JF - JAMA AU - Donnelly, W J AD - Medical Service, Veterans Administration Hospital, Hines, IL 60141. PY - 1988 SP - 823 EP - 825 VL - 260 IS - 6 SN - 0098-7484, 0098-7484 KW - Emotions KW - Human KW - Internship and Residency KW - Social Values KW - Comprehension KW - Physicians KW - Interviews KW - Hospitals, Teaching KW - Physician-Patient Relations KW - Medical History Taking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Righting+the+medical+record.+Transforming+chronicle+into+story.&rft.au=Donnelly%2C+W+J&rft.aulast=Donnelly&rft.aufirst=W&rft.date=1988-08-01&rft.volume=260&rft.issue=6&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Spontaneous group B Salmonella enteritidis peritonitis in cirrhotic ascites and acquired immune deficiency syndrome. AN - 85218972; pmid-3293435 AB - Salmonella represents an infrequent cause of spontaneous bacterial peritonitis in cirrhotic ascites. A cirrhotic patient, an alcoholic and former intravenous drug abuser, developed spontaneous group B Salmonella enteritidis (undetermined serotype) bacterial peritonitis. The isolation of this pathogen, a common cause of bacteremia in acquired immune deficiency syndrome, led to the serological determination of infection with human immune deficiency virus (HIV). JF - The American Journal of Gastroenterology AU - Reddy, K R AU - Chan, J C AU - Smiley, D AU - Jeffers, L J AU - Schiff, E R AD - Department of Medicine, Veterans Administration Medical Center, University of Miami School of Medicine, Florida. PY - 1988 SP - 882 EP - 884 VL - 83 IS - 8 SN - 0002-9270, 0002-9270 KW - HIV Seropositivity KW - Ascites KW - Human KW - Peritonitis KW - Middle Age KW - Case Report KW - Liver Cirrhosis, Alcoholic KW - Male KW - Salmonella enteritidis KW - Salmonella Infections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85218972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Spontaneous+group+B+Salmonella+enteritidis+peritonitis+in+cirrhotic+ascites+and+acquired+immune+deficiency+syndrome.&rft.au=Reddy%2C+K+R%3BChan%2C+J+C%3BSmiley%2C+D%3BJeffers%2C+L+J%3BSchiff%2C+E+R&rft.aulast=Reddy&rft.aufirst=K&rft.date=1988-08-01&rft.volume=83&rft.issue=8&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Angiodysplasia of the upper gastrointestinal tract. AN - 85214101; pmid-3047221 AB - I have reviewed the English language literature on angiodysplasia of the upper gastrointestinal tract. Angiodysplasia is a distinct mucosal vascular lesion associated with acute or chronic gastrointestinal bleeding. Its etiology is unknown, but theories of its pathogenesis have evolved from its similarity to colonic angiodysplasia and an association with renal failure. Despite recurrent gastrointestinal bleeding, the endoscopic diagnosis is difficult because the lesions are so small and so similar to fresh blood. Endoscopic ablation by electrocautery or laser photocoagulation can reduce bleeding or make it stop, but repeated treatments are often necessary. JF - Journal of Clinical Gastroenterology AU - Gilmore, P R AD - Department of Medicine, Boston Veterans Administration Medical Center, Massachusetts 02130. PY - 1988 SP - 386 EP - 394 VL - 10 IS - 4 SN - 0192-0790, 0192-0790 KW - Esophagus KW - Gastrointestinal System KW - Stomach Diseases KW - Human KW - Gastric Mucosa KW - Mucous Membrane KW - Gastrointestinal Hemorrhage KW - Kidney Failure, Chronic KW - Esophageal Diseases KW - Intestinal Mucosa KW - Aortic Valve Stenosis KW - Duodenal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85214101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Angiodysplasia+of+the+upper+gastrointestinal+tract.&rft.au=Gilmore%2C+P+R&rft.aulast=Gilmore&rft.aufirst=P&rft.date=1988-08-01&rft.volume=10&rft.issue=4&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Lymphocyte subset alterations in patients with alcoholic hepatitis. AN - 78569870; 3199427 AB - Twenty-three patients with alcoholic hepatitis (AH) were entered into a study to evaluate the relationship between alcoholic hepatitis, malnutrition, and immune status. In order to quantify these variables, objective parameters of nutritional status and lymphocyte phenotype and function were used. On admission to hospital, the mean number of CD4 helper/inducer cells, CD8 suppressor/cytotoxic cells, and CD3 lymphocytes were significantly reduced compared to age matched, non-hospitalized laboratory controls. In order to ascertain whether this abnormality was reversible, 12 patients, who were willing to remain in the hospital for 30 days, were treated for this entire period with oral nutritional supplementation using a commercially available preparation high in calories, protein, and branch chain amino acids. After 30 days of this therapy and abstinence, the number of CD4 cells increased from a mean (+/- SD) of 658 +/- 428 to 815 +/- 599/mm3. There was no difference in results of the lymphocyte transformation test comparing pre- and post-therapy values using either fetal calf or autologous serum. For all groups tested, cells cultured in autologous serum exhibited a significantly decreased response to mitogen compared to cells cultured in fetal calf serum. Both the total nutritional and the protein depletion (kwashiorkor) scores improved significantly during the 30 days of nutritional supplementation (p less than 0.0009 and p less than 0.0004, respectively). Therefore, we have observed an alteration in the numbers of helper lymphocytes in patients admitted with AH. This abnormality was modifiable by abstinence and nutritional supplementation over a brief period of hospitalization. JF - Journal of clinical & laboratory immunology AU - Roselle, G A AU - Mendenhall, C L AU - Grossman, C J AU - Weesner, R E AD - Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 169 EP - 173 VL - 26 IS - 4 SN - 0141-2760, 0141-2760 KW - Index Medicus KW - Lymphocyte Activation KW - Protein Deficiency -- immunology KW - Patient Admission KW - Protein Deficiency -- diet therapy KW - Humans KW - Temperance KW - Statistics as Topic KW - Hepatitis, Alcoholic -- diet therapy KW - Lymphocytes -- immunology KW - Hepatitis, Alcoholic -- immunology KW - Lymphocytes -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78569870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+%26+laboratory+immunology&rft.atitle=Lymphocyte+subset+alterations+in+patients+with+alcoholic+hepatitis.&rft.au=Roselle%2C+G+A%3BMendenhall%2C+C+L%3BGrossman%2C+C+J%3BWeesner%2C+R+E&rft.aulast=Roselle&rft.aufirst=G&rft.date=1988-08-01&rft.volume=26&rft.issue=4&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+%26+laboratory+immunology&rft.issn=01412760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-24 N1 - Date created - 1989-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A nonhypoglycemic chlorpropamide analog that inhibits aldehyde dehydrogenase. AN - 78530562; 3056078 AB - Chlorpropamide (CP), a sulfonylurea-type oral hypoglycemic agent, is known to provoke a flushing reaction reminiscent of the disulfiram-ethanol reaction in certain individuals. This is manifested in rodents by an increase in blood acetaldehyde levels after ethanol administration. When the sulfonamide N1-nitrogen of CP was substituted with an ethyl group, the product, N1-ethylchlorpropamide, was found to be three times as active as CP in raising ethanol-derived blood acetaldehyde. However, whereas CP lowered fasting blood glucose in rats measured over 6 h, N1-ethylchlorpropamide was devoid of hypoglycemic activity, suggesting that the latter might be potentially useful as an alcohol deterrent agent. JF - Alcoholism, clinical and experimental research AU - Nagasawa, H T AU - Elberling, J A AU - Shirota, F N AU - DeMaster, E G AD - Medical Research Laboratories, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 563 EP - 565 VL - 12 IS - 4 SN - 0145-6008, 0145-6008 KW - Alcohol Deterrents KW - 0 KW - Blood Glucose KW - N(1)-ethylchlorpropamide KW - 117048-15-4 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Chlorpropamide KW - WTM2C3IL2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Acetaldehyde -- blood KW - Animals KW - Blood Glucose -- metabolism KW - Hypoglycemia -- chemically induced KW - Male KW - Alcoholism -- drug therapy KW - Chlorpropamide -- pharmacology KW - Chlorpropamide -- analogs & derivatives KW - Aldehyde Dehydrogenase -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78530562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+nonhypoglycemic+chlorpropamide+analog+that+inhibits+aldehyde+dehydrogenase.&rft.au=Nagasawa%2C+H+T%3BElberling%2C+J+A%3BShirota%2C+F+N%3BDeMaster%2C+E+G&rft.aulast=Nagasawa&rft.aufirst=H&rft.date=1988-08-01&rft.volume=12&rft.issue=4&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-30 N1 - Date created - 1988-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes in carbohydrate-deficient transferrin levels after alcohol withdrawal. AN - 78520813; 2903691 AB - Sequential serum levels of carbohydrate-deficient transferrin (CDT) were determined in 72 alcoholics at various intervals during detoxification. Before treatment, 57 patients (79%) had increased CDT values (Group A), whereas in 15 individuals (21%) (Group B), CDT levels were within the normal range. In 51 Group A patients, CDT decreased progressively after cessation of alcohol intake (half-life, 16 +/- 5 days), but fluctuated and remained abnormal in the remaining six. Nine Group B patients maintained normal CDT values throughout the follow-up period, but slightly or moderately increased levels were recorded on one occasion in the other six Group B subjects. Patients whose CDT levels had reached normal values after treatment, showed a recurrent increase in CDT after a relapse. gamma-Glutamyl transferase activities, which were elevated in 56% of Group A and in 80% of Group B alcoholics, showed a decrease after cessation of alcohol consumption in most patients with initially elevated values (Group A, 30 of 32; Group B, 10 of 12). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, as well as mean corpuscular volumes (MCV) were normal in the majority of patients. CDT/total transferrin ratios correlated positively with CDT levels. CDT proved to be the most sensitive marker for chronic alcoholism (79%), whereas GGT activity levels were more useful only in patients with normal CDT levels before alcohol withdrawal. In the assessment of treatment outcome, the combination of CDT and GGT as markers yielded a sensitivity of 95%. JF - Alcoholism, clinical and experimental research AU - Behrens, U J AU - Worner, T M AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 539 EP - 544 VL - 12 IS - 4 SN - 0145-6008, 0145-6008 KW - Transferrin KW - 0 KW - carbohydrate-deficient transferrin KW - Ethanol KW - 3K9958V90M KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Humans KW - Alcoholism -- therapy KW - Adult KW - Aged KW - gamma-Glutamyltransferase -- blood KW - Middle Aged KW - Male KW - Erythrocyte Indices KW - Alcoholism -- blood KW - Transferrin -- metabolism KW - Transferrin -- analogs & derivatives KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78520813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Changes+in+carbohydrate-deficient+transferrin+levels+after+alcohol+withdrawal.&rft.au=Behrens%2C+U+J%3BWorner%2C+T+M%3BLieber%2C+C+S&rft.aulast=Behrens&rft.aufirst=U&rft.date=1988-08-01&rft.volume=12&rft.issue=4&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-30 N1 - Date created - 1988-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polymorphonuclear leukocyte cytoplasts mediate acute lung injury. AN - 78455021; 2844716 AB - Injection of phorbol 12-myristate 13-acetate (PMA) into polymorphonuclear leukocyte (PMN)-depleted, PMN cytoplast-repleted New Zealand White rabbits caused the development of acute lung injury in vivo. PMN cytoplasts are nucleus- and granule-free vesicles of cytoplasm capable of releasing toxic O2 radicals but incapable of releasing granule enzymes. PMN cytoplasts when activated by PMA reduced 66 +/- 12.7 nmol of cytochrome c compared with 2.6 +/- 0.7 nmol in their resting state and did not release a significant quantity of granule enzymes (P greater than 0.05). Injection of PMA into New Zealand White rabbits caused a significant decrease (P less than 0.05) in the number of circulating cytoplasts. Increases in lung weight-to-body weight ratios in PMA-treated rabbits (9.8 +/- 0.5 X 10(-3] compared with saline-treated rabbits (5.3 +/- 0.2 X 10(-3] were also noted. Levels of angiotensin-converting enzyme in lung lavage as well as the change in alveolar-arterial O2 ratio correlated with the numbers of cytoplasts in lung lavage (P = 0.001, r = 0.84 and P = 0.0166, r = 0.73, respectively). Albumin in lung lavage increased to 1,700 +/- 186 mg/ml in PMA-treated rabbits from 60 +/- 30 mg/ml in saline-treated rabbits. These changes were attenuated by pretreatment of rabbits with dimethylthiourea (DMTU). In vitro, cytoplasts were able to mediate increases in endothelial monolayer permeability. This was evidenced by increases in fractional transit of albumin across endothelial monolayers when treated with PMA-activated cytoplasts (0.08 +/- 0.01 to 0.28 +/- 0.02).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Antony, V B AU - Owen, C L AU - English, D AD - Department of Medicine, Veterans Administration Medical Center, Indianapolis, Indiana. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 706 EP - 713 VL - 65 IS - 2 SN - 8750-7587, 8750-7587 KW - Superoxides KW - 11062-77-4 KW - 1,3-dimethylthiourea KW - 8P30PMD17W KW - Peptidyl-Dipeptidase A KW - EC 3.4.15.1 KW - Thiourea KW - GYV9AM2QAG KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Endothelium -- metabolism KW - Humans KW - Rabbits KW - Chemotaxis, Leukocyte KW - Thiourea -- analogs & derivatives KW - Superoxides -- metabolism KW - Bronchoalveolar Lavage Fluid -- analysis KW - Thiourea -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Peptidyl-Dipeptidase A -- metabolism KW - Cell Membrane Permeability KW - Pulmonary Edema -- etiology KW - Bronchoalveolar Lavage Fluid -- enzymology KW - Pulmonary Edema -- physiopathology KW - Bronchoalveolar Lavage Fluid -- cytology KW - Neutrophils -- metabolism KW - Lung Diseases -- etiology KW - Lung Diseases -- physiopathology KW - Neutrophils -- physiology KW - Lung -- metabolism KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78455021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Polymorphonuclear+leukocyte+cytoplasts+mediate+acute+lung+injury.&rft.au=Antony%2C+V+B%3BOwen%2C+C+L%3BEnglish%2C+D&rft.aulast=Antony&rft.aufirst=V&rft.date=1988-08-01&rft.volume=65&rft.issue=2&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-22 N1 - Date created - 1988-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Orthostatic hypotension occurring after discontinuation of long-term minoxidil therapy. AN - 78454563; 3173816 AB - Minoxidil (Loniten), a potent predominant arteriolar vasodilator, provides prompt and effective reduction of blood pressure in many patients with severe hypertension. Minoxidil results, however, in profound reflex tachycardia and increased plasma volume almost always necessitating concomitant use of beta-adrenergic blocking agents and diuretics. Hypertrichosis and massive fluid retention are troublesome adverse reactions that may require discontinuation of minoxidil and initiation of an alternative antihypertensive agent. When minoxidil is discontinued, diuretic dosage requires re-evaluation and possible tapering to prevent volume depletion. Volume depletion is a risk factor in patients with persistent peripheral edema, sodium deprivation or dehydration; these states may interfere with physiologic mechanisms that maintain adequate cerebral perfusion upon standing, triggering orthostatic hypotension and potential syncope. Hypertension clinic visits should routinely include supine followed by sitting and standing blood pressure determinations to ensure detection of orthostatic hypotension. Described in the article is a case study in which a patient developed severe orthostatic hypotension one month after minoxidil was discontinued. Pathophysiologic mechanisms are discussed. JF - The Nurse practitioner AU - Noel, H C AD - Hypertension/Cardiology clinics, U.S. Veterans Administration Medical Center, West Haven, Conn. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 25 EP - 2 VL - 13 IS - 8 SN - 0361-1817, 0361-1817 KW - Diuretics KW - 0 KW - Minoxidil KW - 5965120SH1 KW - Index Medicus KW - Nursing KW - Water-Electrolyte Imbalance -- chemically induced KW - Diuretics -- therapeutic use KW - Risk Factors KW - Humans KW - Middle Aged KW - Water-Electrolyte Balance KW - Time Factors KW - Male KW - Hypertension -- drug therapy KW - Minoxidil -- adverse effects KW - Hypotension, Orthostatic -- chemically induced KW - Minoxidil -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78454563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Orthostatic+hypotension+occurring+after+discontinuation+of+long-term+minoxidil+therapy.&rft.au=Noel%2C+H+C&rft.aulast=Noel&rft.aufirst=H&rft.date=1988-08-01&rft.volume=13&rft.issue=8&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-07 N1 - Date created - 1988-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mucosal immune response to cholera toxin in ageing rats. I. Antibody and antibody-containing cell response. AN - 78448535; 3169843 AB - Although ageing is accompanied by systemic immunodeficiencies, the status of the mucosal immune system in the elderly remains unresolved. The gastrointestinal mucosal immune response was evaluated in young, mature and old male rats subjected to intra-intestinal immunization with cholera toxin (CTx). Five days following secondary immunization, the alpha-CTx-IgA titre in the bile of immunized rats was markedly reduced, i.e. the values measured in young rats were approximately five-fold higher than those of old animals. alpha-CTx-IgA levels in non-immunized rats were negligible and age-related shifts in other antibody titres (alpha-CTx IgG and IgM) were not significant. The antibody response to CTx was not reflected in the total IgA content of the samples. The number of alpha-CTx antibody-containing cells (ACCs) in the small intestinal lamina propria was significantly reduced in old immunized rats in comparison with the young or mature animals. These data suggest that ageing compromises both non-immune cell (antibody transport by hepatocytes) and immune cell (number of ACCs in the gut wall) functions in response to cholera toxin immunization in this animal model. JF - Immunology AU - Schmucker, D L AU - Daniels, C K AU - Wang, R K AU - Smith, K AD - Cell Biology and Aging Section, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 691 EP - 695 VL - 64 IS - 4 SN - 0019-2805, 0019-2805 KW - Antibodies, Bacterial KW - 0 KW - Immunoglobulin A KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Immunoglobulin A -- analysis KW - Intestine, Small -- immunology KW - Male KW - Cholera Toxin -- immunology KW - Intestinal Mucosa -- immunology KW - Antibodies, Bacterial -- biosynthesis KW - Antibody-Producing Cells -- immunology KW - Aging -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78448535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Mucosal+immune+response+to+cholera+toxin+in+ageing+rats.+I.+Antibody+and+antibody-containing+cell+response.&rft.au=Schmucker%2C+D+L%3BDaniels%2C+C+K%3BWang%2C+R+K%3BSmith%2C+K&rft.aulast=Schmucker&rft.aufirst=D&rft.date=1988-08-01&rft.volume=64&rft.issue=4&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-21 N1 - Date created - 1988-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunology. 1981 Jul;43(3):401-7 [6972910] J Immunol. 1981 Jun;126(6):2200-4 [6164724] Scand J Immunol. 1983 Feb;17(2):115-21 [6188201] Immunology. 1983 Nov;50(3):407-13 [6226592] Eur J Immunol. 1984 May;14(5):420-5 [6723772] J Clin Immunol. 1984 Mar;4(2):85-91 [6427274] Gastroenterology. 1985 Feb;88(2):436-43 [3965333] Arch Gerontol Geriatr. 1984 Jul;3(2):175-88 [6476977] J Immunol. 1984 Jun;132(6):2730-5 [6609959] J Immunol. 1985 Jun;134(6):3855-8 [3989300] J Infect Dis. 1985 May;151(5):845-9 [3989318] Immunology. 1985 Oct;56(2):345-50 [4054945] Gastroenterology. 1987 Sep;93(3):539-49 [3497070] J Am Geriatr Soc. 1986 May;34(5):377-84 [3514735] Mech Ageing Dev. 1977 Jan-Feb;6(1):15-24 [13249] Proc Soc Exp Biol Med. 1980 Jul;164(3):312-6 [7403099] J Immunol. 1981 Feb;126(2):472-7 [7005339] Jpn J Med Sci Biol. 1982 Feb;35(1):17-23 [7098131] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Perfusion distribution and lung thermal volume in canine hydrochloric acid aspiration. AN - 78442741; 3139618 AB - We investigated the effects of a brief period of positive end-expiratory pressure (PEEP) ventilation or nitroglycerin (NTG) infusion on the distribution of pulmonary blood flow and extravascular thermal volume (ETV) in anesthetized dogs with unilateral HCl lung injury. ETV was determined by the thermal dye technique by use of a monoexponential extrapolation to exclude recirculating indicator, and regional blood flow was determined by a particle distribution technique (radiolabeled plastic microspheres). The lungs were weighted after the animals were killed, and extravascular lung mass (ELM) was determined with the use of hemoglobin to correct for trapped lung blood. Measurements were obtained before instillation of HCl into the right lung and repeated 3 h later before, during, and after PEEP ventilation or NTG infusion. Fractional perfusion of the severely injured portion of the right lung (Qinj/QT) fell from 44.3 +/- 11.1% at base line to 27.8 +/- 15.4% after the onset of lung injury. PEEP produced an acute reversible increase in ETV (63 +/- 37% over average of pre- and post-PEEP values), and the changes in ETV were closely correlated with changes in Qinj/QT (r = 0.91). NTG infusion produced insignificant increases in ETV (14 +/- 10% over average of pre- and postinfusion values) and Qinj/QT (59 +/- 35%), but the changes in ETV and Qinj/QT were strongly correlated (r = 0.92). The fraction of extravascular lung mass detected by the thermodilution measurement averaged 0.44 (range 0.24-0.77).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Carlile, P V AU - Hagan, S F AU - Gray, B A AD - Pulmonary Disease and Critical Care Medicine Section, Veterans Administration Medical Center, Oklahoma City, Oklahoma. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 750 EP - 759 VL - 65 IS - 2 SN - 8750-7587, 8750-7587 KW - Nitroglycerin KW - G59M7S0WS3 KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Pulmonary Gas Exchange KW - Animals KW - Nitroglycerin -- pharmacology KW - Perfusion KW - Blood Flow Velocity KW - Dogs KW - Vascular Resistance -- drug effects KW - Positive-Pressure Respiration KW - Blood Pressure -- drug effects KW - Cardiac Output -- drug effects KW - Lung -- blood supply KW - Extracellular Space -- metabolism KW - Pulmonary Edema -- chemically induced KW - Pulmonary Circulation -- drug effects KW - Pulmonary Edema -- physiopathology KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78442741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Perfusion+distribution+and+lung+thermal+volume+in+canine+hydrochloric+acid+aspiration.&rft.au=Carlile%2C+P+V%3BHagan%2C+S+F%3BGray%2C+B+A&rft.aulast=Carlile&rft.aufirst=P&rft.date=1988-08-01&rft.volume=65&rft.issue=2&rft.spage=750&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-22 N1 - Date created - 1988-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. AN - 78379989; 3136661 AB - The pathway by which cholecystokinin octapeptide (CCK-8) inhibits motility of the proximal stomach and the role of this pathway in the CCK-induced delay in gastric emptying of a liquid meal has been studied in rats by selective destruction of vagal afferent C-fibers using bilateral perineural application of the sensory neurotoxin, capsaicin, 3 or 4 days prior to the experiment. The capsaicin treatment significantly attenuated the decrease in intragastric pressure in urethan-anesthetized rats in response to CCK-8 (0.1-100 pmol iv) compared with vehicle-treated controls. Removal of the celiac-superior mesenteric ganglion completely abolished the inhibitory action of CCK-8 on gastric motility in these rats. In contrast, only celiac ganglionectomy in combination with vagotomy abolished the CCK-8 effect in vehicle-treated controls. Intravenous injection of CCK-8 (300 pmol) 5 min before intragastric administration of a methylcellulose solution decreased gastric emptying by 55% in conscious control or vehicle-treated rats. Perivagal capsaicin treatment abolished the delay in gastric emptying induced by CCK-8. In addition, capsaicin treatment alone significantly increased gastric emptying. These results demonstrate that CCK-8 decreases gastric motility in the gastric corpus and delays gastric emptying by a capsaicin-sensitive vagal afferent pathway. These same afferent fibers may also play a physiological role in the gastric emptying of liquids. JF - The American journal of physiology AU - Raybould, H E AU - Taché, Y AD - Center for Ulcer Research and Education, Veterans Administration Wadsworth Medical Center, Los Angeles, California. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - G242 EP - G246 VL - 255 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Atropine KW - 7C0697DR9I KW - Sincalide KW - M03GIQ7Z6P KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Rats KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Animals KW - Reference Values KW - Vagotomy KW - Pressure KW - Atropine -- pharmacology KW - Vagus Nerve -- physiology KW - Stomach -- innervation KW - Stomach -- physiology KW - Vagus Nerve -- drug effects KW - Gastrointestinal Motility -- drug effects KW - Sincalide -- pharmacology KW - Gastric Emptying -- drug effects KW - Capsaicin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78379989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Cholecystokinin+inhibits+gastric+motility+and+emptying+via+a+capsaicin-sensitive+vagal+pathway+in+rats.&rft.au=Raybould%2C+H+E%3BTach%C3%A9%2C+Y&rft.aulast=Raybould&rft.aufirst=H&rft.date=1988-08-01&rft.volume=255&rft.issue=2+Pt+1&rft.spage=G242&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-14 N1 - Date created - 1988-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Na+ and H+ transport in human jejunal brush-border membrane vesicles. AN - 78370211; 2841867 AB - We have examined pH gradient-driven Na+ uptake and Na+-driven H+ transport in brush-border membrane vesicles prepared from jejunal tissue obtained from organ donors by measuring the influx of 22Na and the fluorescence quenching of acridine orange (AO). Vesicle preparation by either Ca2+ or Mg2+ precipitation showed no difference in 22Na uptake or AO fluorescence quenching and dissipation. An outward H+ gradient [intravesicular pH (pHi) 5.5; extravesicular pH (pHo) 7.5] induced a Na+ uptake "overshoot" of threefold over equilibrium, whereas the absence of an H+ gradient (at either pH 5.5 or 7.5) did not produce an overshoot. Voltage clamping by Ki+ = Ko+ plus valinomycin reduced the overshoot by 50%. The initial rate of pH-driven Na+ uptake in voltage-clamped vesicles was related to [Nao+] (Km = 29 mM and Vmax = 9.5 nmol.mg protein-1.3 s-1). Amiloride inhibited this uptake in voltage-clamped vesicles (Ki = 99 microM). Dissipation of AO fluorescence quench in vesicles with a preformed internal acid gradient was hastened by Nao+ as well as voltage clamping in the absence of Na+. In vesicles without a pH gradient, internal Na+, as well as a diffusion potential (Ki+ 100; Ko+ 0 plus valinomycin) in the absence of Na+, induced AO quenching. External Na+ and Li+, but not choline, acted to dissipate AO quenching induced by a diffusion potential, and the rate of dissipation was unaffected by the presence of Cl-.Li+ and NH4+, but not Cs+, K+, Rb+, or choline+, inhibited pH gradient-driven 22Na uptake. We conclude that human jejunal brush-border membrane vesicles contain conductive pathways for both Na+ and H+ and an Na+-H+ exchanger. JF - The American journal of physiology AU - Kleinman, J G AU - Harig, J M AU - Barry, J A AU - Ramaswamy, K AD - Nephrology Section, Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - G206 EP - G211 VL - 255 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Carrier Proteins KW - 0 KW - Sodium-Hydrogen Antiporter KW - Valinomycin KW - 2001-95-8 KW - Amiloride KW - 7DZO8EB0Z3 KW - Sodium KW - 9NEZ333N27 KW - Acridine Orange KW - F30N4O6XVV KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Spectrometry, Fluorescence KW - Valinomycin -- pharmacology KW - Kinetics KW - Hydrogen-Ion Concentration KW - Humans KW - Potassium -- pharmacology KW - Amiloride -- pharmacology KW - Microvilli -- drug effects KW - Carrier Proteins -- metabolism KW - Microvilli -- metabolism KW - Sodium -- metabolism KW - Jejunum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78370211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Na%2B+and+H%2B+transport+in+human+jejunal+brush-border+membrane+vesicles.&rft.au=Kleinman%2C+J+G%3BHarig%2C+J+M%3BBarry%2C+J+A%3BRamaswamy%2C+K&rft.aulast=Kleinman&rft.aufirst=J&rft.date=1988-08-01&rft.volume=255&rft.issue=2+Pt+1&rft.spage=G206&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-14 N1 - Date created - 1988-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics. AN - 78361393; 3404978 AB - When peripheral nerves of experimental rats are exposed to local anesthetics, distinctive and reproducible pathologic changes occur involving the perineurial sheath and endoneurial contents. Application of intermediate strength concentrations of the local anesthetics, 2-chloroprocaine, lidocaine, etidocaine, and intermediate or high concentrations of procaine to the surface of rat sciatic nerves resulted in the following changes. By 48 hours, the perineurial sheath exposed to the drug was disrupted and became permeable to granulocytes which infiltrated the subjacent endoneurium in conjunction with edema formation in the endoneurial interstitium. Application of 10% procaine to exposed nerve resulted in extensive demyelination. The most striking pathologic change occurring with either intermediate or high doses was accumulation of lipid droplets in Schwann cells, a phenomenon that occurred often in myelin-producing Schwann cells but much less frequently in unmyelinated fiber Schwann Cells. Lipid accumulation appears to be one of several reactive changes that affect Schwann cells of myelinated fibers and is dose-dependent. On the other hand, while reactive changes were infrequently seen in unmyelinated fiber Schwann cells, these cells appeared more susceptible to injury as shown by electron microscopy. Injury to Schwann cells by local anesthetics is temporary because these cells can replicate quickly. Autoradiographic studies of thymidine incorporation 1 week after procaine administration to the sciatic nerve showed intense proliferation of Schwann cells, but no such activity in controls. These findings support the view that their neurotoxic properties may account in some part for the function of local anesthetics, that Schwann cells of small unmyelinated fibers are more vulnerable to these agents than those of myelinated fibers, and that destruction of their supporting cells is followed by vigorous mitotic activity in the endoneurium. JF - Laboratory investigation; a journal of technical methods and pathology AU - Powell, H C AU - Kalichman, M W AU - Garrett, R S AU - Myers, R R AD - Veterans Administration Research Service, San Diego, La Jolla, California. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 271 EP - 280 VL - 59 IS - 2 SN - 0023-6837, 0023-6837 KW - Anesthetics, Local KW - 0 KW - Procaine KW - 4Z8Y51M438 KW - chloroprocaine KW - 5YVB0POT2H KW - Lidocaine KW - 98PI200987 KW - Etidocaine KW - I6CQM0F31V KW - Index Medicus KW - Myelin Sheath -- ultrastructure KW - Lidocaine -- administration & dosage KW - Animals KW - Procaine -- analogs & derivatives KW - Axons -- drug effects KW - Dose-Response Relationship, Drug KW - Etidocaine -- administration & dosage KW - Procaine -- toxicity KW - Etidocaine -- toxicity KW - Autoradiography KW - Lidocaine -- toxicity KW - Rats, Inbred Strains KW - Rats KW - Myelin Sheath -- pathology KW - Myelin Sheath -- drug effects KW - Procaine -- administration & dosage KW - Microscopy, Electron KW - Injections KW - Female KW - Lipid Metabolism KW - Anesthetics, Local -- administration & dosage KW - Schwann Cells -- ultrastructure KW - Schwann Cells -- drug effects KW - Anesthetics, Local -- toxicity KW - Schwann Cells -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78361393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Selective+vulnerability+of+unmyelinated+fiber+Schwann+cells+in+nerves+exposed+to+local+anesthetics.&rft.au=Powell%2C+H+C%3BKalichman%2C+M+W%3BGarrett%2C+R+S%3BMyers%2C+R+R&rft.aulast=Powell&rft.aufirst=H&rft.date=1988-08-01&rft.volume=59&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-13 N1 - Date created - 1988-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunologic response to Faenia rectivirgula (Micropolyspora faeni) in a dairy farm family. AN - 78359737; 3042838 AB - In the present study, cellular and humoral responses to Faenia rectivirgula antigens were evaluated in seven subjects, members of a family who lived and worked on a dairy farm. Four subjects had clinical features of hypersensitivity pneumonitis after exposure to moldy hay. The other three subjects had no clinical disease in spite of similar exposure. Although serum precipitins were found in most subjects, a biotin-avidin-linked immunosorbent assay revealed high levels of F. rectivirgula-specific antibodies only in the symptomatic subjects. In addition, numerous precipitin arcs were present in the sera of the symptomatic but not the asymptomatic subjects by antigen-antibody crossed immunoelectrophoresis. No clear distinction between symptomatic and asymptomatic subjects could be made on the basis of lymphocyte phenotype studies, and antigen-induced lymphocyte transformation was not detected in any subjects. The results indicate that F. rectivirgula-specific antibody levels as detected by biotin-avidin-linked immunosorbent assay and by the presence of precipitin arcs in crossed immunoelectrophoresis may differentiate symptomatic and asymptomatic farmers. JF - The Journal of allergy and clinical immunology AU - Brummund, W AU - Kurup, V P AU - Resnick, A AU - Milson, T J AU - Fink, J N AD - Research Service, Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295-1000. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 190 EP - 195 VL - 82 IS - 2 SN - 0091-6749, 0091-6749 KW - Antigens, Differentiation, B-Lymphocyte KW - 0 KW - Antigens, Differentiation, T-Lymphocyte KW - Abridged Index Medicus KW - Index Medicus KW - Phenotype KW - Antigens, Differentiation, T-Lymphocyte -- analysis KW - Actinomycetales Infections -- complications KW - Farmer's Lung -- genetics KW - Farmer's Lung -- etiology KW - Humans KW - Antibody Formation KW - Immunosorbent Techniques KW - Precipitin Tests KW - Immunoelectrophoresis, Two-Dimensional KW - Farmer's Lung -- immunology KW - Antigens, Differentiation, B-Lymphocyte -- analysis KW - Micromonosporaceae -- immunology KW - Dairying UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78359737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Immunologic+response+to+Faenia+rectivirgula+%28Micropolyspora+faeni%29+in+a+dairy+farm+family.&rft.au=Brummund%2C+W%3BKurup%2C+V+P%3BResnick%2C+A%3BMilson%2C+T+J%3BFink%2C+J+N&rft.aulast=Brummund&rft.aufirst=W&rft.date=1988-08-01&rft.volume=82&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-21 N1 - Date created - 1988-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A randomized trial of acetohydroxamic acid for the treatment and prevention of infection-induced urinary stones in spinal cord injury patients. AN - 78353835; 3294442 AB - Acetohydroxamic acid is known to inhibit bacterial urease activity, thus, reducing urinary ammonia levels. A double-blind placebo-controlled clinical trial of acetohydroxamic acid was conducted at 12 Veterans Administration spinal cord injury units. A total of 210 male spinal cord injury patients with chronic urea-splitting urinary infection was enrolled for a scheduled followup of 2 years. The study data support the usefulness of acetohydroxamic acid in reducing urinary ammonia. At every followup visit the acetohydroxamic acid patients with stones had decreases in ammonia of 30 to 48 mg. per dh., while the placebo patients had increases in ammonia. Acetohydroxamic acid also retarded stone growth. Patients with stones treated with acetohydroxamic acid exhibited significantly longer intervals from randomization to first stone growth than patients treated with placebo (p less than 0.005, medians 15 versus 9 months). Acetohydroxamic acid reduced significantly the proportion of patients with stone growth at 12 months (33 versus 60 per cent, p equals 0.017). This decrease was diminished at 24 months (42 versus 60 per cent, p equals 0.260). Patient attrition was 31 per cent in the placebo group and 62 per cent in the acetohydroxamic acid group, the latter attrition being primarily owing to patient request because of mild symptoms. Of the acetohydroxamic acid and placebo patients 62 and 29 per cent, respectively, reported drug side effects but all were reversible and no unanticipated or life-threatening reactions occurred. JF - The Journal of urology AU - Griffith, D P AU - Khonsari, F AU - Skurnick, J H AU - James, K E AD - Veterans Administration Medical Center, Houston, Texas. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 318 EP - 324 VL - 140 IS - 2 SN - 0022-5347, 0022-5347 KW - Hydroxamic Acids KW - 0 KW - acetohydroxamic acid KW - 4RZ82L2GY5 KW - Ammonia KW - 7664-41-7 KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Middle Aged KW - Ammonia -- urine KW - Male KW - Urinary Calculi -- prevention & control KW - Spinal Cord Injuries -- complications KW - Urinary Calculi -- urine KW - Hydroxamic Acids -- therapeutic use KW - Hydroxamic Acids -- adverse effects KW - Urinary Calculi -- etiology KW - Urinary Tract Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=A+randomized+trial+of+acetohydroxamic+acid+for+the+treatment+and+prevention+of+infection-induced+urinary+stones+in+spinal+cord+injury+patients.&rft.au=Griffith%2C+D+P%3BKhonsari%2C+F%3BSkurnick%2C+J+H%3BJames%2C+K+E&rft.aulast=Griffith&rft.aufirst=D&rft.date=1988-08-01&rft.volume=140&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms. AN - 78348826; 3403719 AB - Using isolated, in situ, single-pass perfused rat livers, incubations of freshly isolated hepatocytes, and sinusoidal membrane-enriched vesicles, we and others have shown the saturability of transport (efflux) of hepatic glutathione (GSH). These observations have implicated a carrier mechanism. Our present studies were designed to provide further evidence in support of a carrier mechanism for hepatic GSH efflux by demonstrating competition by liver-specific ligands which are taken up by hepatocytes. Perfusing livers with different substances, we found that: (a) sulfobromophthalein-GSH (BSP-GSH) had a dose-dependent and fully reversible inhibitory effect on GSH efflux, while GSH alone did not have any effect; (b) taurocholate had no inhibitory effect; (c) all of the organic anions studied, i.e., BSP, rose bengal, indocyanine green, and unconjugated bilirubin (UCB), manifested potent, dose-dependent inhibitory effects, with absence of toxic effects and complete reversibility of inhibition in the case of UCB. The inhibitory effects of UCB could be overcome partially by raising (CoCl2-induced) hepatic GSH concentration. Because of the physiological importance of UCB, we conducted a detailed study of its inhibitory kinetics in the isolated hepatocyte model in the range of circulating concentrations of UCB. Studies with Cl- -free media, to inhibit the uptake of UCB by hepatocytes, showed that the inhibition of GSH efflux by UCB is apparently from inside the cell. This point was confirmed by showing that the inhibition is overcome only when bilirubin-loaded cells are cleared of bilirubin (incubation with 5% bovine serum albumin). Using Gunn rat hepatocytes and purified bilirubin mono- and diglucuronides, we found that both UCB and glucuronide forms of bilirubin inhibit GSH efflux in a dose-dependent manner. We conclude that the organic anions, although taken up by a mechanism independent of GSH, may competitively inhibit the carrier for GSH efflux from inside the hepatocyte. JF - The Journal of clinical investigation AU - Ookhtens, M AU - Lyon, I AU - Fernandez-Checa, J AU - Kaplowitz, N AD - Liver Research Laboratory, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 608 EP - 616 VL - 82 IS - 2 SN - 0021-9738, 0021-9738 KW - Bile Acids and Salts KW - 0 KW - Fluorescent Dyes KW - Sulfobromophthalein KW - 0C2P5QKL36 KW - bilirubin glucuronate KW - 27071-67-6 KW - (sulfobromophthalein)glutathione conjugate KW - 52682-84-5 KW - Glutathione KW - GAN16C9B8O KW - Bilirubin KW - RFM9X3LJ49 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Bile Acids and Salts -- pharmacology KW - Animals KW - Sulfobromophthalein -- pharmacology KW - Kinetics KW - Rats, Gunn KW - Cell Separation KW - Male KW - Biological Transport -- drug effects KW - Liver -- cytology KW - Perfusion KW - Glutathione -- antagonists & inhibitors KW - Liver -- drug effects KW - Glutathione -- metabolism KW - Bilirubin -- analogs & derivatives KW - Bilirubin -- pharmacology KW - Liver -- metabolism KW - Glutathione -- pharmacology KW - Fluorescent Dyes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78348826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Inhibition+of+glutathione+efflux+in+the+perfused+rat+liver+and+isolated+hepatocytes+by+organic+anions+and+bilirubin.+Kinetics%2C+sidedness%2C+and+molecular+forms.&rft.au=Ookhtens%2C+M%3BLyon%2C+I%3BFernandez-Checa%2C+J%3BKaplowitz%2C+N&rft.aulast=Ookhtens&rft.aufirst=M&rft.date=1988-08-01&rft.volume=82&rft.issue=2&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-20 N1 - Date created - 1988-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Biochem. 1969 Mar;27(3):502-22 [4388022] Biochem J. 1965 Mar;94:705-11 [14340062] J Clin Invest. 1975 Nov;56(5):1280-92 [1184749] Clin Sci Mol Med. 1976 Aug;51(2):169-76 [954363] Methods Enzymol. 1978;52:60-71 [672656] J Clin Invest. 1981 Apr;67(4):1003-15 [7204563] J Pharmacol Exp Ther. 1983 Jan;224(1):141-7 [6848740] Eur J Biochem. 1984 Feb 1;138(3):491-5 [6692832] J Biol Chem. 1984 Apr 25;259(8):4998-5002 [6715333] Hepatology. 1984 Jul-Aug;4(4):586-90 [6745847] J Clin Invest. 1985 Jan;75(1):258-65 [3965506] Biochem J. 1985 Feb 1;225(3):787-805 [3919713] Annu Rev Pharmacol Toxicol. 1985;25:715-44 [3890714] Am J Physiol. 1986 Feb;250(2 Pt 1):G236-43 [3953803] Biochem J. 1986 Feb 15;234(1):101-9 [3707537] J Biol Chem. 1986 Jun 15;261(17):7860-5 [2872220] Am J Physiol. 1986 Sep;251(3 Pt 1):G354-61 [3752249] Biochem Biophys Res Commun. 1987 Feb 27;143(1):377-82 [3827928] J Clin Invest. 1987 Apr;79(4):1259-68 [3031134] J Lab Clin Med. 1970 Apr;75(4):542-57 [5444343] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monocyte-associated tissue factor is suppressed by phorbol myristate acetate. AN - 78346899; 2840984 AB - The monocyte is the only normal circulating cell type capable of initiating blood coagulation through the expression of tissue factor. Recently isolated peripheral blood monocytes that contain no demonstrable tissue factor activity can be induced to express tissue factor activity by a number of stimulatory agents. Monocyte-associated tissue factor activity transiently increases in response to adherence to tissue culture plates and, consistent with other reports, markedly increases after the isolated monocytes are treated with endotoxin. Phorbol myristate acetate (PMA) induced an increase in tissue factor activity at low doses (10(-11) to 10(-12) mol/L). Conversely, concentrations of PMA that stimulate release of oxygen metabolites or that cause the cytosol-to-membrane translocation of protein kinase C (PKC) (10(-9) to 10(-7) mol/L) resulted in a rapid decrease in both adherence-induced and endotoxin-induced monocyte tissue factor activity. The effects of PMA on monocytes were time- and dose-dependent with respect to PKC translocation, release of oxygen metabolites, and changes in tissue factor activity. Immunofluorescent staining of monocytes with monoclonal antibody (MoAb) HTF1-7B8, directed against human tissue factor, revealed that tissue factor antigen was induced concurrently with tissue factor activity by adherence and endotoxin and that tissue factor antigen decreased after PMA stimulation. JF - Blood AU - Brozna, J P AU - Carson, S D AD - Department of Pathology, Veterans Administration Medical Center, Denver, CO 80220. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 456 EP - 462 VL - 72 IS - 2 SN - 0006-4971, 0006-4971 KW - Superoxides KW - 11062-77-4 KW - Thromboplastin KW - 9035-58-9 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Protein Kinase C -- metabolism KW - Superoxides -- metabolism KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Time Factors KW - Fluorescent Antibody Technique KW - Monocytes -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects KW - Thromboplastin -- biosynthesis KW - Thromboplastin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78346899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Monocyte-associated+tissue+factor+is+suppressed+by+phorbol+myristate+acetate.&rft.au=Brozna%2C+J+P%3BCarson%2C+S+D&rft.aulast=Brozna&rft.aufirst=J&rft.date=1988-08-01&rft.volume=72&rft.issue=2&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-21 N1 - Date created - 1988-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Endotoxin and pulmonary cell injury. AN - 78344953; 3041636 AB - The physiopathologic similarity between adult respiratory distress syndrome (ARDS) secondary to sepsis and endotoxin-induced pulmonary abnormalities has provided extensive descriptive information confirming bacterial endotoxin as a factor initiating the heterogeneous pulmonary changes in ARDS. The present studies have used an established in vitro model for pulmonary cell injury to examine bacterial endotoxin 1, as a direct cytotoxic agent on the two major alveolar cell types, pulmonary endothelium and epithelium; 2, as a stimulant of neutrophil-mediated pulmonary cell injury, and 3, to examine effector mechanisms of cell-mediated damage by studying the potential effectiveness of antioxidants and antiproteolytic agents in the inhibition of this process. Endotoxin direct toxicity and stimulation of neutrophil-mediated pulmonary cell injury was observed in both pulmonary cell populations in systems free of activated serum complement. Endothelial cells were observed to be more susceptible to both the direct effect of endotoxin and to neutrophil-mediated injury when compared with epithelial cell derived monolayers. The addition of an antiprotease (soybean trypsin inhibitor [STI]) was superior to antioxidants (catalase, superoxide dismutase) in reducing the neutrophil-mediated endothelial toxicity (stimulated 51CR per cent release) observed. A 92 per cent degree of protection was observed with the highest dose of STI (5 milligrams per milliliter) used. Proteases released by activated neutrophils on endotoxin stimulation appear to be the predominant toxic species responsible for endothelial injury in this system. JF - Surgery, gynecology & obstetrics AU - Bloom, R J AU - Simon, L M AU - Benitz, W E AD - Department of Surgery, Veterans Administration Medical Center, Palo Alto, California 94304. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 92 EP - 98 VL - 167 IS - 2 SN - 0039-6087, 0039-6087 KW - Antioxidants KW - 0 KW - Endotoxins KW - Trypsin Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Endothelium, Vascular -- drug effects KW - Cell Survival -- drug effects KW - Antioxidants -- pharmacology KW - Cells, Cultured KW - Humans KW - Epithelium -- physiology KW - Escherichia coli KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Neutrophils -- physiology KW - Epithelium -- drug effects KW - Trypsin Inhibitors -- pharmacology KW - Endothelium, Vascular -- physiology KW - Lung -- drug effects KW - Lung -- physiology KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78344953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery%2C+gynecology+%26+obstetrics&rft.atitle=Endotoxin+and+pulmonary+cell+injury.&rft.au=Bloom%2C+R+J%3BSimon%2C+L+M%3BBenitz%2C+W+E&rft.aulast=Bloom&rft.aufirst=R&rft.date=1988-08-01&rft.volume=167&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Surgery%2C+gynecology+%26+obstetrics&rft.issn=00396087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. AN - 78336674; 3396644 AB - Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine. Treatment with 20 mg/kg diazepam was initiated at the time each of four EEG patterns was seen: (i) discrete electrographic seizures; (ii) waxing and waning epileptiform activity; (iii) continuous, high-amplitude, rapid spiking; and (iv) periodic epileptiform discharges (PEDs) on a relatively flat background. Success of diazepam in stopping all seizure activity was predicted by the EEG pattern seen at the time of treatment. All rats treated while displaying discrete electrographic seizures had status stopped with diazepam, but only three of six with waxing and waning epileptiform activity and one of six each with continuous spiking and PEDs. Rats which continued to seize had a decrease in spike amplitude of 74.8 +/- 18.25% following diazepam injection. These data confirm the clinical impression that the longer the duration of status epilepticus, the more difficult it is to control and suggest that the EEG pattern at the time of treatment predicts the probability of success. JF - Experimental neurology AU - Walton, N Y AU - Treiman, D M AD - Neurology Services, Veterans Administration West Los Angeles Medical Center, California 90073. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 267 EP - 275 VL - 101 IS - 2 SN - 0014-4886, 0014-4886 KW - Pilocarpine KW - 01MI4Q9DI3 KW - Lithium KW - 9FN79X2M3F KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Electroencephalography KW - Reaction Time KW - Diazepam -- blood KW - Status Epilepticus -- chemically induced KW - Diazepam -- therapeutic use KW - Status Epilepticus -- physiopathology KW - Status Epilepticus -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78336674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Response+of+status+epilepticus+induced+by+lithium+and+pilocarpine+to+treatment+with+diazepam.&rft.au=Walton%2C+N+Y%3BTreiman%2C+D+M&rft.aulast=Walton&rft.aufirst=N&rft.date=1988-08-01&rft.volume=101&rft.issue=2&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-07 N1 - Date created - 1988-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhaled tobacco sterols: uptake by the lungs and disposition to selected organs of rats. AN - 78333956; 3397625 AB - Tobacco sterols (cholesterol, beta-sitosterol, campesterol, and stigmasterol) are present in tobacco smoke and appear in plasma of mammals exposed to cigarette smoke. Because tobacco sterols may be important in the pathogenesis of smoking-induced lung and vascular diseases, we studied the pattern of deposition of cigarette sterols in the lungs and appearance of cigarette sterols in plasma and body organs of rats. After exposure to twenty 5 ml "puffs" of smoke from tobacco labeled with [4-14C]cholesterol or beta-[4-14C]sitosterol, rats were killed just after exposure (day 0) and on days 2, 5, 8, 11, 15, and 30, and the lungs and selected body organs analyzed for activity. We found that cigarette sterols are associated with particulates in cigarette smoke, deposited mostly in distal airspaces and parenchyma of the lungs, and appear in plasma and several body organs for more than 30 days after this single exposure to cigarette smoke. Bronchoalveolar lavage fluid contained relatively small amounts of radiolabel for only the first few days, suggesting that most of the sterols were rapidly incorporated in lung parenchyma. Because disorders of sterol metabolism have been implicated in a variety of diseases including atherosclerosis and cancer, the significance of tobacco sterols to human smoking-induced diseases deserves further study. JF - The Journal of laboratory and clinical medicine AU - Holden, W E AU - Maier, J M AU - Liebler, J M AU - Malinow, M R AD - Department of Medicine, Portland Veterans Administration Medical Center, OR 97207. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 216 EP - 222 VL - 112 IS - 2 SN - 0022-2143, 0022-2143 KW - Phytosterols KW - 0 KW - Sitosterols KW - Smoke KW - Sterols KW - campesterol KW - 5L5O665639 KW - gamma-sitosterol KW - 5LI01C78DD KW - Cholesterol KW - 97C5T2UQ7J KW - Stigmasterol KW - 99WUK5D0Y8 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Esophagus -- metabolism KW - Spleen -- metabolism KW - Liver -- metabolism KW - Tissue Distribution KW - Stigmasterol -- pharmacokinetics KW - Rats KW - Rats, Inbred Strains KW - Stomach -- metabolism KW - Sitosterols -- pharmacokinetics KW - Bronchoalveolar Lavage Fluid -- analysis KW - Cholesterol -- analogs & derivatives KW - Cholesterol -- pharmacokinetics KW - Male KW - Plants, Toxic KW - Sterols -- pharmacokinetics KW - Tobacco KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78333956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Inhaled+tobacco+sterols%3A+uptake+by+the+lungs+and+disposition+to+selected+organs+of+rats.&rft.au=Holden%2C+W+E%3BMaier%2C+J+M%3BLiebler%2C+J+M%3BMalinow%2C+M+R&rft.aulast=Holden&rft.aufirst=W&rft.date=1988-08-01&rft.volume=112&rft.issue=2&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hemodynamic, renal, and neurohumoral effects of a selective oral DA1 receptor agonist (fenoldopam) in patients with congestive heart failure. AN - 78328432; 2899970 AB - Fenoldopam mesylate (SK&F 82526-J) is a novel benzazepine derivative. It has selective agonist activity at post-junctional (DA1) vascular dopaminergic receptors, which normally subserve renal artery vasodilation. Previous studies in normal subjects and in patients with hypertension indicate that fenoldopam increases renal blood flow and promotes a sodium diuresis. Drug efficacy was clinically evaluated in eight patients with chronic congestive heart failure (CHF) after a single oral dose of 100 mg of fenoldopam and following 3 days of therapy (100 mg four times daily). Stroke volume index acutely increased from 26 +/- 7 (mean +/- SD) to 30 +/- 4 ml/beat/m2 (p less than 0.05) and left ventricular filling pressure decreased from 26 +/- 13 to 23 +/- 11 mm Hg (p less than 0.05). Systemic vascular resistance decreased from 1513 +/- 159 to 1128 +/- 319 (p less than 0.05). Hemodynamic changes were seen as early as 30 minutes following fenoldopam and returned to control levels by 4 hours. Forearm blood flow, hepatic blood flow, and venous capacitance did not significantly change acutely, but renal blood flow index was significantly reduced (34 +/- 4 to 30 +/- 3 min-1 X 1000, p less than 0.01). Plasma norepinephrine, plasma renin activity, plasma arginine vasopressin, and plasma aldosterone did not significantly change acutely. After 3 days of treatment, 100 mg of fenoldopam again reduced the renal blood flow index (35 +/- 7 to 26 +/- 7 min-1 X 1000, p less than 0.01) and tended to increase plasma renin activity (11.7 +/- 8 to 21.2 +/- 19.4 ng/ml/hr, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS) JF - American heart journal AU - Francis, G S AU - Wilson, B C AU - Rector, T S AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 473 EP - 479 VL - 116 IS - 2 Pt 1 SN - 0002-8703, 0002-8703 KW - Benzazepines KW - 0 KW - Receptors, Dopamine KW - Vasodilator Agents KW - Arginine Vasopressin KW - 113-79-1 KW - Aldosterone KW - 4964P6T9RB KW - Renin KW - EC 3.4.23.15 KW - Fenoldopam KW - INU8H2KAWG KW - Norepinephrine KW - X4W3ENH1CV KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Administration, Oral KW - Renin -- metabolism KW - Arginine Vasopressin -- metabolism KW - Norepinephrine -- metabolism KW - Humans KW - Middle Aged KW - Regional Blood Flow KW - Kidney -- physiopathology KW - Aldosterone -- metabolism KW - Receptors, Dopamine -- drug effects KW - Receptors, Dopamine -- physiology KW - Heart Failure -- drug therapy KW - Benzazepines -- administration & dosage KW - Vasodilator Agents -- adverse effects KW - Vasodilator Agents -- administration & dosage KW - Benzazepines -- adverse effects KW - Vasodilator Agents -- therapeutic use KW - Heart Failure -- metabolism KW - Benzazepines -- therapeutic use KW - Heart Failure -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78328432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Hemodynamic%2C+renal%2C+and+neurohumoral+effects+of+a+selective+oral+DA1+receptor+agonist+%28fenoldopam%29+in+patients+with+congestive+heart+failure.&rft.au=Francis%2C+G+S%3BWilson%2C+B+C%3BRector%2C+T+S&rft.aulast=Francis&rft.aufirst=G&rft.date=1988-08-01&rft.volume=116&rft.issue=2+Pt+1&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Precipitation of dialysis dementia by deferoxamine treatment of aluminum-related bone disease. AN - 78328159; 3400633 AB - Five patients with chronic renal failure, complicated by bone aluminum toxicity, were treated with deferoxamine (DFO). This treatment appeared to precipitate dialysis dementia, which was fatal in three patients. In two patients, continuous treatment with lower doses of DFO was possible. The development of dialysis dementia in chronic renal failure patients with very high serum aluminum levels may be a complication of DFO treatment. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Sherrard, D J AU - Walker, J V AU - Boykin, J L AD - Department of Medicine, Seattle Veterans Administration Medical Center, WA 98108. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 126 EP - 130 VL - 12 IS - 2 SN - 0272-6386, 0272-6386 KW - Aluminum KW - CPD4NFA903 KW - Deferoxamine KW - J06Y7MXW4D KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Bone Diseases -- therapy KW - Aluminum -- adverse effects KW - Deferoxamine -- adverse effects KW - Bone Diseases -- complications KW - Kidney Failure, Chronic -- therapy KW - Deferoxamine -- therapeutic use KW - Dementia -- chemically induced KW - Kidney Failure, Chronic -- complications KW - Renal Dialysis -- adverse effects KW - Bone Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78328159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Precipitation+of+dialysis+dementia+by+deferoxamine+treatment+of+aluminum-related+bone+disease.&rft.au=Sherrard%2C+D+J%3BWalker%2C+J+V%3BBoykin%2C+J+L&rft.aulast=Sherrard&rft.aufirst=D&rft.date=1988-08-01&rft.volume=12&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-07 N1 - Date created - 1988-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitation and fractionation of nutrient hepatic blood flow in normal persons, in persons with portal hypertensive cirrhosis, and after small-diameter portacaval H grafts. AN - 78326045; 3400065 AB - Patients maintaining portal perfusion following small-diameter portacaval H grafts have better survival and lower portasystemic encephalopathy rates than those with reversed flow. To determine why this is so, we measured nutrient hepatic blood flow with the use of 99m-Tc-diisopropyl-IDA (DISIDA) clearance pharmacokinetics fractionated into its hepatic arterial and portal venous components. Patients with cirrhosis and portal hypertension had significantly lower nutrient hepatic blood flow than normal persons; this was due almost entirely to reduced portal flow. In patients with prograde portal flow after small-diameter H grafts nutrient hepatic blood flows were nominally reduced from levels seen in patients with portal hypertensive cirrhosis. Postoperative patients with reversed portal flow had significantly less nutrient hepatic blood than those with prograde flow. There was no evidence of significant hepatic arterial compensation for lost portal flow. Of four hemodynamic variables--portal flow direction, portal flow, arterial flow, and nutrient hepatic blood flow--only nutrient hepatic blood flow showed an independent correlation with clinical outcome. Portal perfusion is a critical factor in maintenance of adequate nutrient hepatic blood flow, primarily because hepatic arterial flow does not compensate chronically for lost portal perfusion. JF - Surgery AU - Rypins, E B AU - Milne, N AU - Sarfeh, I J AU - Lyons, K P AD - Surgical Service, Long Beach Veterans Administration Medical Center, Calif. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 335 EP - 342 VL - 104 IS - 2 SN - 0039-6060, 0039-6060 KW - Imino Acids KW - 0 KW - Organometallic Compounds KW - Technetium Tc 99m Disofenin KW - QTJ2VIW97T KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Hepatic Encephalopathy -- physiopathology KW - Hemodynamics KW - Liver -- diagnostic imaging KW - Hypertension, Portal -- physiopathology KW - Radionuclide Imaging KW - Liver Circulation KW - Liver Cirrhosis, Alcoholic -- physiopathology KW - Portasystemic Shunt, Surgical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78326045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery&rft.atitle=Quantitation+and+fractionation+of+nutrient+hepatic+blood+flow+in+normal+persons%2C+in+persons+with+portal+hypertensive+cirrhosis%2C+and+after+small-diameter+portacaval+H+grafts.&rft.au=Rypins%2C+E+B%3BMilne%2C+N%3BSarfeh%2C+I+J%3BLyons%2C+K+P&rft.aulast=Rypins&rft.aufirst=E&rft.date=1988-08-01&rft.volume=104&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Surgery&rft.issn=00396060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Partial prevention of procarbazine induced germinal cell aplasia in rats by sequential GnRH antagonist and testosterone administration. AN - 78307757; 3134124 AB - The present study examined the feasibility of using a combination of gonadotropin releasing hormone antagonist (GnRH-A) and testosterone in the prevention of procarbazine induced germinal aplasia. Daily injections of GnRH-A or vehicle were given to adult male rats for 21 days prior to procarbazine (PCB) administration and continued until 2 days after the second of two doses of procarbazine (200 mg/kg i.p.) given 1 week apart. One group of rats receiving GnRH-A and PCB was given s.c. two 5-cm testosterone capsule (TC) implants (inside diameter, 3.5 mm) immediately following the second dose of PCB. Eight weeks after the last PCB treatment, more than 99% of the seminiferous tubular cross-sections of rats receiving PCB alone were devoid of spermatogenic activity. Spermatogenesis in PCB injected animals receiving GnRH-A pretreatment alone was abortive but was partially preserved when exogenous testosterone was given following PCB administration. At 16 weeks, spermatogenesis was absent in all PCB treated animals and was only observed in less than 1% of the tubular cross-sections of the PCB treated rats receiving GnRH-A pretreatment alone. On the other hand, active spermatogenesis was noted in 68% of the tubular cross-sections, and complete spermatogenesis was noted in four of the five PCB treated rats receiving both GnRH-A pretreatment and subsequent TC implantation. At the time of sacrifice, testicular testosterone concentrations in animals receiving TC implants were below 10% of normal levels, while both serum and testicular testosterone content were increased in PCB treated animals with or without GnRH-A pretreatment. Concomitantly, testicular androgen binding protein content remained suppressed and serum androgen binding protein was elevated, indicating a prolonged defect in Sertoli cell function. These lesions were prevented by GnRH-A pretreatment. The present study demonstrates that GnRH-A pretreatment and subsequent TC implantation resulted in restoration of complete spermatogenesis in adult male rats given a 400-mg/kg cumulative dose of PCB. It is postulated that GnRH-A may ameliorate PCB induced Sertoli cell dysfunction and/or stimulate the number of spermatogonia to provide more proliferating cells ready for repopulation of the germinal epithelium following PCB injury. The differentiation of these spermatogonia was further supported by exogenous testosterone through certain unknown local mechanisms, resulting in the completion of spermatogenesis. JF - Cancer research AU - Pogach, L M AU - Lee, Y AU - Gould, S AU - Giglio, W AU - Huang, H F AD - Department of Medicine, East Orange Veterans Administration Medical Center, New Jersey 07019. Y1 - 1988/08/01/ PY - 1988 DA - 1988 Aug 01 SP - 4354 EP - 4360 VL - 48 IS - 15 SN - 0008-5472, 0008-5472 KW - Androgen-Binding Protein KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Procarbazine KW - 35S93Y190K KW - Testosterone KW - 3XMK78S47O KW - LHRH, Ac-dehydro-Pro(1)-4-F-Phe(2)-Trp(3,6)- KW - 78708-43-7 KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Androgen-Binding Protein -- analysis KW - Animals KW - Drug Interactions KW - Luteinizing Hormone -- blood KW - Male KW - Follicle Stimulating Hormone -- blood KW - Organ Size -- drug effects KW - Testis -- physiopathology KW - Testosterone -- pharmacology KW - Testis -- drug effects KW - Procarbazine -- toxicity KW - Testis -- pathology KW - Gonadotropin-Releasing Hormone -- antagonists & inhibitors KW - Spermatogenesis -- drug effects KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78307757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Partial+prevention+of+procarbazine+induced+germinal+cell+aplasia+in+rats+by+sequential+GnRH+antagonist+and+testosterone+administration.&rft.au=Pogach%2C+L+M%3BLee%2C+Y%3BGould%2C+S%3BGiglio%2C+W%3BHuang%2C+H+F&rft.aulast=Pogach&rft.aufirst=L&rft.date=1988-08-01&rft.volume=48&rft.issue=15&rft.spage=4354&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-24 N1 - Date created - 1988-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gastric adaptation. Studies in humans during continuous aspirin administration. AN - 78303819; 3260568 AB - To study the process of gastric mucosal adaptation to aspirin administration, 14 normal men underwent a study with continued administration of aspirin. Endoscopic assessment, biopsies, and gastric wash collections for acid, mucus, and deoxyribonucleic acid recovery were performed weekly; aspirin was continued until the endoscopy showed minimal damage. Six subjects took 650 mg of aspirin b.i.d., and 8 took 650 mg q.i.d.; adaptation and resolution took longer with the higher dose (median 4.5 wk vs. 1 wk, p less than 0.01). Despite improvement in mucosal appearance, gastric microbleeding remained elevated throughout aspirin administration. In contrast, deoxyribonucleic acid recovery (a marker for cellular exfoliation and regeneration) increased significantly just before the time of resolution, when, on average, it more than doubled. As no other biochemical or histologic changes could be associated with the resolution of damages, we conclude that gastric adaptation to chronic injury may involve increased cellular regeneration. JF - Gastroenterology AU - Graham, D Y AU - Smith, J L AU - Spjut, H J AU - Torres, E AD - Department of Medicine, Veterans Administration Medical Center, Houston, Texas. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 327 EP - 333 VL - 95 IS - 2 SN - 0016-5085, 0016-5085 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Gastroscopy KW - Humans KW - Adult KW - Adaptation, Physiological KW - Gastrointestinal Contents -- analysis KW - Time Factors KW - Gastrointestinal Hemorrhage -- chemically induced KW - Male KW - Cell Division KW - Aspirin -- toxicity KW - Gastric Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78303819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Gastric+adaptation.+Studies+in+humans+during+continuous+aspirin+administration.&rft.au=Graham%2C+D+Y%3BSmith%2C+J+L%3BSpjut%2C+H+J%3BTorres%2C+E&rft.aulast=Graham&rft.aufirst=D&rft.date=1988-08-01&rft.volume=95&rft.issue=2&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-12 N1 - Date created - 1988-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of acetaldehyde on human red cell metabolism: evidence for the formation of enzyme inhibitors. AN - 78422433; 3416486 AB - Since red cells transport and metabolize acetaldehyde in vivo, the effects of acetaldehyde on human red cell enzyme activities were studied. Incubation of intact red cells or undiluted red cell lysates at 37 degrees C for 4 h with 1-10 mmol/l acetaldehyde decreased only GOT, GPT and aldolase activities among the 26 enzymes tested. No inhibition occurred at 4 degrees C or when acetaldehyde was incubated with dilute hemolysates. Incubation of lysates with other reducing substrates or with acetate inhibited aldolase but not GOT or GPT. Preincubation of lysates with cyanate or fluoride markedly decreased acetaldehyde-mediated transaminase inhibition but not aldolase inhibition. Addition of pyridoxal phosphate, the vitamin B6 transaminase coenzyme, to GOT and GPT assay mixes did not reverse acetaldehyde-mediated transaminase inhibition. These findings suggest that acetaldehyde-mediated aldolase inhibition results from oxidation of acetaldehyde while transaminase inhibition results from nonoxidative acetaldehyde metabolism. When 100-200 mumol/l acetaldehyde is added to lysates at 2-h intervals and when lysates are incubated with ethanol, alcohol dehydrogenase and an NAD-regenerating system, enzyme inhibition occurs at acetaldehyde levels approaching those seen in vivo. Thus, the role of acetaldehyde-mediated enzyme inhibition in the toxicity of alcohol abuse warrants further study. JF - Clinica chimica acta; international journal of clinical chemistry AU - Solomon, L R AD - Department of Medicine, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1988/07/29/ PY - 1988 DA - 1988 Jul 29 SP - 249 EP - 265 VL - 175 IS - 3 SN - 0009-8981, 0009-8981 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Fructose-Bisphosphate Aldolase KW - EC 4.1.2.13 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- antagonists & inhibitors KW - Aspartate Aminotransferases -- antagonists & inhibitors KW - Alanine Transaminase -- blood KW - Fructose-Bisphosphate Aldolase -- antagonists & inhibitors KW - Humans KW - In Vitro Techniques KW - Fructose-Bisphosphate Aldolase -- blood KW - Acetaldehyde -- blood KW - Erythrocytes -- drug effects KW - Erythrocytes -- enzymology KW - Acetaldehyde -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78422433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.atitle=Effects+of+acetaldehyde+on+human+red+cell+metabolism%3A+evidence+for+the+formation+of+enzyme+inhibitors.&rft.au=Solomon%2C+L+R&rft.aulast=Solomon&rft.aufirst=L&rft.date=1988-07-29&rft.volume=175&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.issn=00098981&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Singlet oxygen production by human eosinophils. AN - 78282309; 2838476 AB - Human eosinophils, stimulated with phorbol myristate acetate, were found to produce 1268 nm chemiluminescence characteristic of singlet oxygen. Singlet oxygen generation required the presence of bromide ion. A bromide ion concentration of 100 microM, comparable to the total bromine content of whole blood, was sufficient for the eosinophils to generate measurable amounts of singlet oxygen. For the conditions used (10(7) cells/ml and 10 micrograms/ml phorbol myristate acetate), the duration of the singlet oxygen generation was brief, about 5 min, and the total yield of singlet oxygen was modest, 1.0 +/- 0.1 microM. The cells remained viable after the singlet oxygen production ceased. This is the first demonstration of singlet oxygen production from living cells. The singlet oxygen generated by eosinophils likely results from a peroxidase-catalyzed mechanism, since a purified eosinophil peroxidase-hydrogen peroxide-bromide system was also shown to produce singlet oxygen. The unique properties of eosinophil peroxidase are illustrated by the fact that at p2H 7.0 and with 100 microM bromide, eosinophil peroxidase generated 20 +/- 2% of the theoretical yield of singlet oxygen, whereas under identical conditions, myeloperoxidase and lactoperoxidase produced only 1.0 +/- 0.1% and -0.1 +/- 0.1%, respectively. JF - The Journal of biological chemistry AU - Kanofsky, J R AU - Hoogland, H AU - Wever, R AU - Weiss, S J AD - Medical Service, Edward Hines, Jr. Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1988/07/15/ PY - 1988 DA - 1988 Jul 15 SP - 9692 EP - 9696 VL - 263 IS - 20 SN - 0021-9258, 0021-9258 KW - Bromides KW - 0 KW - Singlet Oxygen KW - 17778-80-2 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidase KW - EC 1.11.1.7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Photochemistry KW - Bromides -- blood KW - Luminescent Measurements KW - Kinetics KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Spectrophotometry KW - Hydrogen Peroxide -- blood KW - Peroxidase -- blood KW - Oxygen -- blood KW - Eosinophils -- drug effects KW - Eosinophils -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78282309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Singlet+oxygen+production+by+human+eosinophils.&rft.au=Kanofsky%2C+J+R%3BHoogland%2C+H%3BWever%2C+R%3BWeiss%2C+S+J&rft.aulast=Kanofsky&rft.aufirst=J&rft.date=1988-07-15&rft.volume=263&rft.issue=20&rft.spage=9692&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-08 N1 - Date created - 1988-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Familial pulmonary capillary hemangiomatosis resulting in primary pulmonary hypertension. AN - 78266324; 3382104 AB - We describe the first cases of familial pulmonary capillary hemangiomatosis, a disorder in which capillaries in the lungs proliferate. Three siblings died from primary pulmonary hypertension. One developed pulmonary congestion preterminally after vasodilator treatment. The inheritance pattern seems autosomal recessive. Lung specimens obtained in two siblings showed extensive pulmonary capillary hemangiomatosis, with normal capillaries proliferating into veins and alveoli. Including our patients, four of the nine patients with pulmonary capillary hemangiomatosis have presented with the clinical picture of primary pulmonary hypertension. Thus, pulmonary capillary hemangiomatosis should be considered as a histologic pattern of primary pulmonary hypertension. Most other cases of pulmonary capillary hemangiomatosis have been similar to pulmonary veno-occlusive disease. Recently, disorders involving the proliferation of cytologically normal capillaries have been termed angiogenic diseases. Pulmonary capillary hemangiomatosis may be an angiogenic disease. JF - Annals of internal medicine AU - Langleben, D AU - Heneghan, J M AU - Batten, A P AU - Wang, N S AU - Fitch, N AU - Schlesinger, R D AU - Guerraty, A AU - Rouleau, J L AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1988/07/15/ PY - 1988 DA - 1988 Jul 15 SP - 106 EP - 109 VL - 109 IS - 2 SN - 0003-4819, 0003-4819 KW - Vasodilator Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Lung -- blood supply KW - Capillaries -- pathology KW - Humans KW - Adult KW - Vasodilator Agents -- adverse effects KW - Pulmonary Edema -- chemically induced KW - Lung -- pathology KW - Male KW - Female KW - Hypertension, Pulmonary -- drug therapy KW - Hemangioma -- genetics KW - Lung Neoplasms -- complications KW - Hemangioma -- complications KW - Hypertension, Pulmonary -- etiology KW - Hemangioma -- pathology KW - Lung Neoplasms -- genetics KW - Hypertension, Pulmonary -- genetics KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78266324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Familial+pulmonary+capillary+hemangiomatosis+resulting+in+primary+pulmonary+hypertension.&rft.au=Langleben%2C+D%3BHeneghan%2C+J+M%3BBatten%2C+A+P%3BWang%2C+N+S%3BFitch%2C+N%3BSchlesinger%2C+R+D%3BGuerraty%2C+A%3BRouleau%2C+J+L&rft.aulast=Langleben&rft.aufirst=D&rft.date=1988-07-15&rft.volume=109&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-28 N1 - Date created - 1988-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Ann Intern Med 1988 Sep 1;109(5):439 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nervous system complications in uremia. AN - 78265506; 2837930 AB - In patients with end-stage renal disease, nervous system dysfunction remains a major cause of disability. Patients with chronic renal failure who have not yet received dialysis may have symptoms ranging from mild sensorial clouding to delirium and coma. Dialysis itself is associated with at least three distinct disorders of the central nervous system, including the dialysis disequilibrium syndrome, dialysis dementia, and progressive intellectual dysfunction. Peripheral neuropathy is also a major cause of disability in uremic patients. Aluminum probably contributes to the pathogenesis of dialysis dementia. Parathyroid hormone, the levels of which are elevated in patients with renal failure, also may be a uremic neurotoxin. Biochemically, brain calcium levels are elevated in renal failure, possibly because of the action of parathyroid hormone. Studies on synaptosomes have also shown that parathyroid hormone can affect calcium transport in the brain. Intellectual dysfunction, dialysis dementia, uremic neuropathy, and the dialysis disequilibrium syndrome can be diagnosed when the characteristic clinical findings are present and other causes of nervous system dysfunction have been excluded. JF - Annals of internal medicine AU - Fraser, C L AU - Arieff, A I AD - Veterans Administration Medical Center, San Francisco, California. Y1 - 1988/07/15/ PY - 1988 DA - 1988 Jul 15 SP - 143 EP - 153 VL - 109 IS - 2 SN - 0003-4819, 0003-4819 KW - Parathyroid Hormone KW - 0 KW - Toxins, Biological KW - uremia middle molecule toxins KW - Aluminum KW - CPD4NFA903 KW - Abridged Index Medicus KW - Index Medicus KW - Toxins, Biological -- metabolism KW - Aluminum -- adverse effects KW - Peripheral Nervous System Diseases -- metabolism KW - Peripheral Nervous System Diseases -- etiology KW - Parathyroid Hormone -- physiology KW - Humans KW - Brain Diseases -- etiology KW - Brain Diseases -- metabolism KW - Renal Dialysis -- adverse effects KW - Nervous System Diseases -- etiology KW - Uremia -- metabolism KW - Uremia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78265506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Nervous+system+complications+in+uremia.&rft.au=Fraser%2C+C+L%3BArieff%2C+A+I&rft.aulast=Fraser&rft.aufirst=C&rft.date=1988-07-15&rft.volume=109&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-28 N1 - Date created - 1988-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prednisone withdrawal followed by recombinant alpha interferon in the treatment of chronic type B hepatitis. A randomized, controlled trial. AN - 78263086; 3289433 AB - To determine the efficacy of a short course of prednisone followed by recombinant interferon treatment in patients with chronic type B hepatitis. Randomized, controlled trial with a 5-month treatment phase and a 9-month observation period after treatment. Two referral-based university-affiliated medical centers. Thirty-nine clinically stable patients with chronic type B hepatitis, all of whom were positive for hepatitis B antigen, hepatitis B virus-associated-DNA (HBV-DNA), and DNA polymerase for at least 6 months before entry. Patients included 20 heterosexuals and 19 male homosexuals. Eighteen patients were treated with a 6-week tapered regimen of prednisone, followed by 90 days treatment with recombinant interferon alpha-2b; 21 patients were untreated controls. Paired liver biopsy specimens of 27 patients (pretreatment and 9 months after treatment) were blindly evaluated. Nine treated patients had a sustained loss of HBV-DNA. In addition, eight treated patients lost hepatitis B e antigen and four became negative for hepatitis B surface antigen (HBsAg). When compared with controls the differences were statistically significant for clearance of HBV-DNA and HBsAg (P = 0.035 and 0.037, respectively). Treated patients who had a sustained loss of HBV-DNA had higher initial alanine aminotransferase lower initial DNA and DNA polymerase levels, and were more frequently heterosexual. Patients who responded to treatment with the disappearance of hepatitis B e antigen and HBV-DNA had normal liver function tests and markedly improved liver histology during follow-up. The immunologic priming provided by a short course of prednisone used with alpha interferon may be an effective treatment for selected patients with chronic type B hepatitis. JF - Annals of internal medicine AU - Perrillo, R P AU - Regenstein, F G AU - Peters, M G AU - DeSchryver-Kecskemeti, K AU - Bodicky, C J AU - Campbell, C R AU - Kuhns, M C AD - Veterans Administration Medical Center, St. Louis, Missouri. Y1 - 1988/07/15/ PY - 1988 DA - 1988 Jul 15 SP - 95 EP - 100 VL - 109 IS - 2 SN - 0003-4819, 0003-4819 KW - Interferon Type I KW - 0 KW - Recombinant Proteins KW - Alanine Transaminase KW - EC 2.6.1.2 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Liver -- pathology KW - Random Allocation KW - Combined Modality Therapy KW - Humans KW - Clinical Trials as Topic KW - Alanine Transaminase -- blood KW - DNA-Directed DNA Polymerase -- blood KW - Adult KW - Recombinant Proteins -- adverse effects KW - Hepatitis B virus -- isolation & purification KW - Middle Aged KW - Chronic Disease KW - Recombinant Proteins -- therapeutic use KW - Female KW - Male KW - Interferon Type I -- adverse effects KW - Hepatitis B -- microbiology KW - Prednisone -- adverse effects KW - Hepatitis B -- pathology KW - Interferon Type I -- therapeutic use KW - Hepatitis B -- therapy KW - Prednisone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78263086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Prednisone+withdrawal+followed+by+recombinant+alpha+interferon+in+the+treatment+of+chronic+type+B+hepatitis.+A+randomized%2C+controlled+trial.&rft.au=Perrillo%2C+R+P%3BRegenstein%2C+F+G%3BPeters%2C+M+G%3BDeSchryver-Kecskemeti%2C+K%3BBodicky%2C+C+J%3BCampbell%2C+C+R%3BKuhns%2C+M+C&rft.aulast=Perrillo&rft.aufirst=R&rft.date=1988-07-15&rft.volume=109&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-28 N1 - Date created - 1988-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides. AN - 78253008; 3132464 AB - The expression of cytochromes P450b and P450e genes was studied in the small intestinal mucosa of rats using a cDNA which recognizes the mRNAs of both cytochromes as well as oligonucleotide probes which are able to differentiate between the two gene products. Animals were treated with oral and intraperitoneal doses of phenobarbital, gamma-chlordane, trans-non-achlor, and polychlorinated and polybrominated biphenyls. RNA was extracted from small intestinal mucosa and liver. After treatment with each of the compounds, P450b mRNA was markedly induced in small intestinal mucosa and in liver. The greatest degree of induction was found in mucosa of the proximal small intestine where P450b mRNA levels were 4-6-fold higher than levels found in the distal small intestine. This distribution of P450b mRNA was not dependent on the route of administration of inducers. In contrast, although P450e mRNA was induced in the liver after treatment, P450e mRNA in the small intestine did not increase in response to any of the administered inducers. The location of the P450b mRNA within the intestinal mucosa following treatment with inducers was studied by in situ hybridization; the message was induced predominantly in enterocytes located in intestinal villi. These data indicate that the P450b gene is induced in the small intestine following treatment with various xenobiotics and that this induction may be secondary to either transcriptional activation of the gene or to mRNA stabilization in enterocytes located in the villi of the intestinal mucosa. The differential induction of P450b versus P450e genes in the small intestine and liver indicates that the regulation of these closely linked genes is tissue-specific. Furthermore, the marked induction of P450b mRNA in response to the administered xenobiotics indicates that this isoenzyme may have an important biological role in the small intestinal metabolism of environmental toxicants and drugs. JF - The Journal of biological chemistry AU - Traber, P G AU - Chianale, J AU - Florence, R AU - Kim, K AU - Wojcik, E AU - Gumucio, J J AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1988/07/05/ PY - 1988 DA - 1988 Jul 05 SP - 9449 EP - 9455 VL - 263 IS - 19 SN - 0021-9258, 0021-9258 KW - Aroclors KW - 0 KW - RNA, Messenger KW - Chlorodiphenyl (54% Chlorine) KW - 11097-69-1 KW - Chlordan KW - 12789-03-6 KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Microsomes -- metabolism KW - DNA -- genetics KW - Nucleic Acid Hybridization KW - RNA, Messenger -- genetics KW - Male KW - Microsomes -- drug effects KW - Chlordan -- pharmacology KW - Phenobarbital -- pharmacology KW - Aroclors -- pharmacology KW - Transcription, Genetic -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Polychlorinated Biphenyls -- pharmacology KW - Intestine, Small -- metabolism KW - Genes -- drug effects KW - Intestine, Small -- drug effects KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78253008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Expression+of+cytochrome+P450b+and+P450e+genes+in+small+intestinal+mucosa+of+rats+following+treatment+with+phenobarbital%2C+polyhalogenated+biphenyls%2C+and+organochlorine+pesticides.&rft.au=Traber%2C+P+G%3BChianale%2C+J%3BFlorence%2C+R%3BKim%2C+K%3BWojcik%2C+E%3BGumucio%2C+J+J&rft.aulast=Traber&rft.aufirst=P&rft.date=1988-07-05&rft.volume=263&rft.issue=19&rft.spage=9449&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-27 N1 - Date created - 1988-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Semantic Organization and Classification of Fourteen Words by Aphasic Patients AN - 85497869; 8809424 AB - A study of conceptual organization & classification skills in aphasics examined 14 items that could be classified into the class-related categories "sewing tools" & "carpentry tools" as well as into the functionally related categories "things that attach" & "things that cut." Ss were 5 fluent aphasics, 5 nonfluent aphasics, & 10 normal controls. The stimulus words were used in six tasks: comprehension, word-picture matching, naming, triadic comparison, & two classification tasks. In the first task, Ss were presented with two sets of word triads, each representing a particular class. They were then given individual target words & asked to which triad group they belonged. In the second task, Ss were asked to match the words to descriptions of either the function of class relations. Both groups of aphasics were found to appreciate class & function relations, although the ability to use this information may be impaired on some tasks. It is suggested that knowledge about function makes an inadequate contribution to the organization of conceptual knowledge in fluent aphasics. 4 Tables, 17 References. B. Annesser Murray JF - Brain and Language AU - McCleary, Carol AD - Psychology Research Service 116B Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 183 EP - 202 VL - 34 IS - 2 SN - 0093-934X, 0093-934X KW - semantic organization, classification skills KW - fluent/nonfluent aphasics KW - Word Recognition and Discrimination (wo5) KW - Semantics (se9) KW - Cognitive Processes (co1b) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85497869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Semantic+Organization+and+Classification+of+Fourteen+Words+by+Aphasic+Patients&rft.au=McCleary%2C+Carol&rft.aulast=McCleary&rft.aufirst=Carol&rft.date=1988-07-01&rft.volume=34&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Cognitive Processes (co1b); Word Recognition and Discrimination (wo5); Semantics (se9) ER - TY - JOUR T1 - Collagenous sprue as a cause for malabsorption in a patient with myotonic dystrophy: a new association. AN - 85215828; pmid-3381810 JF - The American Journal of Gastroenterology AU - Woods, C A AU - Foutch, P G AU - Kerr, D M AU - Haynes, W C AU - Sanowski, R A AD - Department of Gastroenterology, Veterans Administration Medical Center, Phoenix, Arizona. PY - 1988 SP - 765 EP - 766 VL - 83 IS - 7 SN - 0002-9270, 0002-9270 KW - Diarrhea KW - Human KW - Jejunum KW - Myotonic Dystrophy KW - Middle Age KW - Case Report KW - Celiac Disease KW - Male KW - Collagen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85215828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Collagenous+sprue+as+a+cause+for+malabsorption+in+a+patient+with+myotonic+dystrophy%3A+a+new+association.&rft.au=Woods%2C+C+A%3BFoutch%2C+P+G%3BKerr%2C+D+M%3BHaynes%2C+W+C%3BSanowski%2C+R+A&rft.aulast=Woods&rft.aufirst=C&rft.date=1988-07-01&rft.volume=83&rft.issue=7&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Failure of a cytoprotective dose of Arbacet to heal acute gastric ulcers. AN - 85213728; pmid-3289379 AB - Twenty outpatients with an endoscopic diagnosis of gastric ulcer were evaluated for 6 wk in a randomized, double-blind trial comparing 15(R)-15-methyl prostaglandin E2 (Arbacet) (10 micrograms, 0.5 h before each meal and at bedtime) with placebo. Endoscopy was performed at 3 wk and 6 wk during the study period. Five of nine patients (56%) taking Arbacet and seven of 11 patients (64%) in the placebo group had complete healing of their gastric ulcer. Healing occurred in four patients from the Arbacet group and three patients in the placebo group at 3 wk. A cytoprotective dose of Arbacet (40 micrograms daily) is not significantly better than placebo in healing gastric ulcers. JF - The American Journal of Gastroenterology AU - Jaszewski, R AU - Crane, S A AD - Department of Gastroenterology, Veterans Administration Medical Center/Wayne State University Affiliated Hospitals, Allen Park, Michigan. PY - 1988 SP - 734 EP - 736 VL - 83 IS - 7 SN - 0002-9270, 0002-9270 KW - Stomach Ulcer KW - Acute Disease KW - Gastroscopy KW - Double-Blind Method KW - Random Allocation KW - Human KW - Clinical Trials KW - Prostaglandins E, Synthetic KW - Comparative Study KW - Support, Non-U.S. Gov't KW - Middle Age KW - Placebos KW - Arbaprostil KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Failure+of+a+cytoprotective+dose+of+Arbacet+to+heal+acute+gastric+ulcers.&rft.au=Jaszewski%2C+R%3BCrane%2C+S+A&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1988-07-01&rft.volume=83&rft.issue=7&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Audiometric configuration as a reflection of diabetes. AN - 85210937; pmid-3177618 AB - The purpose of this study was to investigate whether or not a rising, progressively improving (RPI) sensorineural hearing loss from lower toward higher frequencies might be related to or serve as an indicator or predictor of diabetes. Forty-five subjects between the ages of 21 and 79, demonstrating a RPI audiometric pattern, were considered for a 5-hour oral glucose tolerance test. Based on the National Diabetes Data Group standard, results showed that diabetes mellitus appeared in seven subjects; five subjects had impaired glucose tolerance; and nine subjects had mild but nondiagnostic glucose intolerance. Relatively normal glucose values were demonstrated by 53% of subjects. There may be some value in an RPI audiometric pattern as an indicator or early detection sign for diabetes, but further research is necessary before such conclusions can be drawn. JF - The American Journal of Otology AU - Carmen, R E AU - Svihovec, D AU - Gocka, E F AU - Ermshar, C B AU - Gay, G C AU - Vanore, J F AU - House, L R AD - Audiology and Speech Pathology Service, Veterans Administration Medical Center, Sepulveda, California. PY - 1988 SP - 327 EP - 333 VL - 9 IS - 4 SN - 0192-9763, 0192-9763 KW - Glucose Tolerance Test KW - Meniere's Disease KW - Audiometry, Pure-Tone KW - Human KW - Diabetes Mellitus KW - Aged KW - Hearing Loss, Sensorineural KW - Blood Glucose KW - Speech Discrimination Tests KW - Adult KW - Middle Age KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85210937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Otology&rft.atitle=Audiometric+configuration+as+a+reflection+of+diabetes.&rft.au=Carmen%2C+R+E%3BSvihovec%2C+D%3BGocka%2C+E+F%3BErmshar%2C+C+B%3BGay%2C+G+C%3BVanore%2C+J+F%3BHouse%2C+L+R&rft.aulast=Carmen&rft.aufirst=R&rft.date=1988-07-01&rft.volume=9&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Otology&rft.issn=01929763&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Use of the CUSA in removal of a recurrent intraorbital mucocele. AN - 85201587; pmid-3140186 JF - Otolaryngology--Head and Neck Surgery AU - Gillespie, R P AU - Marshall, A AU - Ludlow, P AD - Division of Neurosurgery and Otolaryngology, Veterans Administration Medical Center, Reno, NV. PY - 1988 SP - 71 EP - 72 VL - 99 IS - 1 SN - 0194-5998, 0194-5998 KW - Mucocele KW - Human KW - Middle Age KW - Case Report KW - Orbital Diseases KW - Suction KW - Male KW - Ultrasonics KW - Surgical Instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Use+of+the+CUSA+in+removal+of+a+recurrent+intraorbital+mucocele.&rft.au=Gillespie%2C+R+P%3BMarshall%2C+A%3BLudlow%2C+P&rft.aulast=Gillespie&rft.aufirst=R&rft.date=1988-07-01&rft.volume=99&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Reference threshold sound-pressure levels for the TDH-50 and ER-3A earphones. AN - 85181719; pmid-3411054 AB - Reference threshold sound-pressure levels were established for a new insert earphone, the ER-3A tubephone, and for the TDH-50 earphone. In test-retest comparisons, the tubephone produced estimates of auditory threshold as reliable as the thresholds produced by the supraaural earphone. Reference thresholds were developed for the two earphones from data contributed by three laboratories. While the TDH-50 data are in good agreement with the provisional ANSI 6-cc coupler reference levels (ASHA, 1982), the ER-3A data are at variance with the manufacturer's provisional recommendation for 2-cc coupler reference thresholds for frequencies below 1 kHz. The differences are attributed to physiologic noise that masked the lower frequency thresholds. JF - The Journal of the Acoustical Society of America AU - Larson, V D AU - Cooper, W A AU - Talbott, Richard Edward AU - Schwartz, D M AU - Ahlstrom, C AU - De Chicchis Albert Richard AD - Audiology Research Program, Veterans Administration Medical Center, Augusta, Georgia 30910.; Department of Communication Sciences and Disorders, College of Allied Health, University of Oklahoma Health Sciences Center, University of Oklahoma; Department of Communication Sciences & Special Education, College of Education, University of Georgia PY - 1988 SP - 46 EP - 51 VL - 84 IS - 1 SN - 0001-4966, 0001-4966 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85181719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Reference+threshold+sound-pressure+levels+for+the+TDH-50+and+ER-3A+earphones.&rft.au=Larson%2C+V+D%3BCooper%2C+W+A%3BTalbott%2C+Richard+Edward%3BSchwartz%2C+D+M%3BAhlstrom%2C+C%3BDe+Chicchis+Albert+Richard&rft.aulast=Larson&rft.aufirst=V&rft.date=1988-07-01&rft.volume=84&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of aging on normal hearing loss and noise-induced threshold shift in albino and pigmented guinea pigs. AN - 85164399; pmid-3421100 AB - In a previous investigation into noise-induced hearing loss by comparing 2-month-old albino with pigmented guinea pigs, albinos displayed significantly greater shifts in cochlear microphonic (CM) threshold and less recovery than the pigmented animals 7 days after noise exposure. The present study compared the responses of 14-month-old albino and pigmented guinea pigs to the same noise parameters used previously. Thresholds for the first detectable elicitation of CM for three pure tones were recorded prior to, at 90 min and at 7 days after a 45-min exposure to 126 dB broadband noise. Before exposure to noise, thresholds for pigmented guinea pigs were 24 dB higher than those in the albinos. Following noise exposure, the pigmented animals showed less than half the amount of threshold shift displayed by the albinos. This change ws attributed to the higher pre-exposure thresholds in the pigmented guinea pigs. Converging lines of evidence suggest that cochlear pigmentation may have both protective and toxic influences on the inner ear. JF - Acta Oto-Laryngologica AU - Conlee, J W AU - Abdul-Baqi, K J AU - McCandless, G A AU - Creel, D J AD - Veterans Administration Medical Center, Salt Lake City, Utah 84148. PY - 1988 SP - 64 EP - 70 VL - 106 IS - 1-2 SN - 0001-6489, 0001-6489 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85164399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Oto-Laryngologica&rft.atitle=Effects+of+aging+on+normal+hearing+loss+and+noise-induced+threshold+shift+in+albino+and+pigmented+guinea+pigs.&rft.au=Conlee%2C+J+W%3BAbdul-Baqi%2C+K+J%3BMcCandless%2C+G+A%3BCreel%2C+D+J&rft.aulast=Conlee&rft.aufirst=J&rft.date=1988-07-01&rft.volume=106&rft.issue=1-2&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Acta+Oto-Laryngologica&rft.issn=00016489&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Nicotine polacrilex: clinic-based strategies with chronically ill smokers. AN - 78712034; 3236143 JF - Journal of psychoactive drugs AU - Carmody, T P AU - Loew, D E AU - Hall, R G AU - Breckenridge, J S AU - Breckenridge, J N AU - Hall, S M AD - Psychology Service, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1988 SP - 269 EP - 274 VL - 20 IS - 3 SN - 0279-1072, 0279-1072 KW - Polymethacrylic Acids KW - 0 KW - Polyvinyls KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Aged KW - Tobacco Use Cessation Products KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Smoking -- physiopathology KW - Nicotine -- therapeutic use KW - Polymethacrylic Acids -- therapeutic use KW - Polyvinyls -- therapeutic use KW - Polyvinyls -- adverse effects KW - Nicotine -- adverse effects KW - Nicotine -- analogs & derivatives KW - Smoking -- psychology KW - Smoking -- drug therapy KW - Polymethacrylic Acids -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78712034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Nicotine+polacrilex%3A+clinic-based+strategies+with+chronically+ill+smokers.&rft.au=Carmody%2C+T+P%3BLoew%2C+D+E%3BHall%2C+R+G%3BBreckenridge%2C+J+S%3BBreckenridge%2C+J+N%3BHall%2C+S+M&rft.aulast=Carmody&rft.aufirst=T&rft.date=1988-07-01&rft.volume=20&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-03 N1 - Date created - 1989-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of clonidine in nicotine withdrawal. AN - 78700315; 3069985 JF - Journal of psychoactive drugs AU - Sees, K L AU - Clark, H W AD - Veterans Administration Medical Center, San Francisco, California 94121. PY - 1988 SP - 263 EP - 268 VL - 20 IS - 3 SN - 0279-1072, 0279-1072 KW - Nicotine KW - 6M3C89ZY6R KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Humans KW - Smoking KW - Substance Withdrawal Syndrome -- prevention & control KW - Clonidine -- administration & dosage KW - Nicotine -- adverse effects KW - Clonidine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78700315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Use+of+clonidine+in+nicotine+withdrawal.&rft.au=Sees%2C+K+L%3BClark%2C+H+W&rft.aulast=Sees&rft.aufirst=K&rft.date=1988-07-01&rft.volume=20&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-03 N1 - Date created - 1989-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A primer on neurotransmitters and cocaine. AN - 78698898; 2906999 JF - Journal of psychoactive drugs AU - Daigle, R D AU - Clark, H W AU - Landry, M J AD - Veterans Administration Medical Center, San Francisco, California. PY - 1988 SP - 283 EP - 295 VL - 20 IS - 3 SN - 0279-1072, 0279-1072 KW - Neurotransmitter Agents KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Humans KW - Substance-Related Disorders -- metabolism KW - Neurotransmitter Agents -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78698898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=A+primer+on+neurotransmitters+and+cocaine.&rft.au=Daigle%2C+R+D%3BClark%2C+H+W%3BLandry%2C+M+J&rft.aulast=Daigle&rft.aufirst=R&rft.date=1988-07-01&rft.volume=20&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-03 N1 - Date created - 1989-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Decrease of benzodiazepine receptors in frontal cortex of alcoholics. AN - 78675035; 2852495 AB - We hypothesize that chronic alcohol abuse results in a loss of neurons and their associated synaptic receptors. This encephalopathy may be a precursor of brain atrophy and end-stage dementia. Autopsies were performed on normal brains of 27 alcoholics (mean age 62.5) and 30 nonalcoholic matched controls (mean age 64.4) free of other brain and liver diseases. None had recently received benzodiazepine medications. Gross brain atrophy was slight and equal in both groups. Benzodiazepine receptor densities and affinities in homogenates of frontal cortex were determined using [3H]flunitrazepam. Bmax specific binding was reduced by 20% in alcoholics compared with nonalcoholic controls of comparable age and with similar death-autopsy time intervals. The affinity was slightly less in the alcoholics. Wet tissue brain protein concentrations and their yields of 50,000-g pellet proteins were similar. Aging, death-autopsy time intervals, pneumonia and chronic obstructive pulmonary disease (diseases usually associated with hypoxia) had no significant effect on brain proteins, receptor densities, or affinities. We conclude that chronic alcoholism is associated with a loss of benzodiazepine receptor densities. Alcohol abuse may affect the results of post-mortem neurochemical investigations of other diseases. JF - Alcohol (Fayetteville, N.Y.) AU - Freund, G AU - Ballinger, W E AD - Veterans Administration Medical Center, Gainesville, FL 32602. PY - 1988 SP - 275 EP - 282 VL - 5 IS - 4 SN - 0741-8329, 0741-8329 KW - Receptors, GABA-A KW - 0 KW - Receptors, Neurotransmitter KW - Ethanol KW - 3K9958V90M KW - Flunitrazepam KW - 620X0222FQ KW - Index Medicus KW - Ethanol -- adverse effects KW - Autopsy KW - Receptors, Neurotransmitter -- metabolism KW - Kinetics KW - Humans KW - Data Interpretation, Statistical KW - Middle Aged KW - Flunitrazepam -- pharmacology KW - Alcoholism -- etiology KW - Frontal Lobe -- metabolism KW - Receptors, GABA-A -- metabolism KW - Alcoholism -- metabolism KW - Receptors, GABA-A -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78675035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Decrease+of+benzodiazepine+receptors+in+frontal+cortex+of+alcoholics.&rft.au=Freund%2C+G%3BBallinger%2C+W+E&rft.aulast=Freund&rft.aufirst=G&rft.date=1988-07-01&rft.volume=5&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-12 N1 - Date created - 1989-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lichen planus following procainamide-induced lupus erythematosus. AN - 78595061; 3203534 AB - A case of procainamide-induced lupus erythematosus with prominent cutaneous features is presented. The patient subsequently showed typical lesions of lichen planus, which has been associated with spontaneously occurring lupus erythematosus, but not previously reported with drug-induced lupus or as a result of procainamide therapy. A review of the immunologic alterations induced by procainamide raises questions about possible mechanisms causing the lupus and lichen planus. JF - Cutis AU - Sherertz, E F AD - Veterans Administration Medical Center, Gainesville, Florida. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 51 EP - 53 VL - 42 IS - 1 SN - 0011-4162, 0011-4162 KW - Procainamide KW - L39WTC366D KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Procainamide -- adverse effects KW - Lichen Planus -- chemically induced KW - Lupus Erythematosus, Discoid -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78595061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Lichen+planus+following+procainamide-induced+lupus+erythematosus.&rft.au=Sherertz%2C+E+F&rft.aulast=Sherertz&rft.aufirst=E&rft.date=1988-07-01&rft.volume=42&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-03 N1 - Date created - 1989-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The comparative recidivism rates of voluntary- and coerced-admission male alcoholics. AN - 78461408; 3170762 AB - The outcomes of inpatient alcoholics who reported that they had been coerced into treatment by commitment or pressure from others were compared in a follow-up study to those of alcoholics who described themselves as voluntary admissions. Ten assessments of control over drinking, number of drinking days in the past week, and intoxication since previous appraisal were made by collaterals between 2 weeks and 18 months after treatment. Even though the data were analyzed in several ways, the number of significant differences did not exceed chance expectations. This suggests that the prognoses of alcoholics who present for treatment under court order or interpersonal pressure were not substantially different from those of men who claim to have entered without coercion. However, the differences between the groups' Control over Drinking ratings, even though not statistically significant, consistently favored the coerced admissions, which raises the possibility that their outcomes may have been slightly better than those of the voluntary admissions. JF - Journal of clinical psychology AU - Watson, C G AU - Brown, K AU - Tilleskjor, C AU - Jacobs, L AU - Pucel, J AD - Research Service, Veterans Administration Medical Center, St. Cloud, Minnesota 56301. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 573 EP - 581 VL - 44 IS - 4 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Humans KW - Adult KW - Prognosis KW - Persuasive Communication KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Patient Compliance KW - Alcoholism -- therapy KW - Commitment of Mentally Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78461408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=The+comparative+recidivism+rates+of+voluntary-+and+coerced-admission+male+alcoholics.&rft.au=Watson%2C+C+G%3BBrown%2C+K%3BTilleskjor%2C+C%3BJacobs%2C+L%3BPucel%2C+J&rft.aulast=Watson&rft.aufirst=C&rft.date=1988-07-01&rft.volume=44&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-07 N1 - Date created - 1988-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Predictors of reduction and cessation of drinking in community-dwelling men: results from the normative aging study. AN - 78453079; 3172785 AB - As part of a longitudinal study of health and aging, the conditions and motivational factors that prospectively predicted either cessation or reduction in alcohol consumption were compared. Data were from 1,517 community-dwelling men who in 1973 (Time 1) and 1982 (Time 2) completed mailed questionnaires about their drinking behaviors. Time 2 quitters (n = 62) had consumed no alcohol for at least the 6 months before that survey; reducers (n = 255) had decreased their yearly alcohol consumption by at least one-half. Compared to 971 controls, quitters reported more drinking problems at Time 1; reducers reported higher consumption at Time 1, which was the only factor predictive of subsequent reduction (p less than .001). Regression analyses considering contextual-motivational factors for drinking showed that at Time 1 quitters were less likely than controls to have consumed alcohol during evenings out (p = .008), in family-home settings (p = .013), or for salutary reasons (p = .084); conversely, they were more likely to have consumed alcohol to reduce negative affect (p = .011). Reducers cited more social-situational reasons for curtailing drinking; quitters cited more personal reasons related to health and alcohol effects. These findings indicate that in a community sample of men, problematic drinking behaviors tend to predict subsequent abstention rather than reduced drinking. JF - Journal of studies on alcohol AU - Hermos, J A AU - Locastro, J S AU - Glynn, R J AU - Bouchard, G R AU - De Labry, L O AD - Medical Service, Boston Veterans Administration Medical Center, Massachusetts 02130. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 363 EP - 368 VL - 49 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Self Disclosure KW - Motivation KW - Aged, 80 and over KW - Social Adjustment KW - Humans KW - Adult KW - Prognosis KW - Aged KW - Middle Aged KW - Boston KW - Longitudinal Studies KW - Male KW - Aging KW - Alcohol Drinking -- psychology KW - Temperance KW - Substance-Related Disorders -- rehabilitation KW - Urban Population UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78453079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Predictors+of+reduction+and+cessation+of+drinking+in+community-dwelling+men%3A+results+from+the+normative+aging+study.&rft.au=Hermos%2C+J+A%3BLocastro%2C+J+S%3BGlynn%2C+R+J%3BBouchard%2C+G+R%3BDe+Labry%2C+L+O&rft.aulast=Hermos&rft.aufirst=J&rft.date=1988-07-01&rft.volume=49&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-21 N1 - Date created - 1988-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers. AN - 78449260; 3172641 AB - Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. QB and QD were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 +/- 2.8 to 80.5 +/- 7.6 ml/min (P less than 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 +/- 113 to 112 +/- 12 min (P less than 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 +/- 191 to 1812 +/- 720 micrograms/hr (P less than 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 +/- 36 vs. 93 +/- 23, P less than 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients. JF - Kidney international AU - Molitoris, B A AU - Alfrey, A C AU - Alfrey, P S AU - Miller, N L AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 98 EP - 101 VL - 34 IS - 1 SN - 0085-2538, 0085-2538 KW - Membranes, Artificial KW - 0 KW - Polymers KW - Sulfones KW - polysulfone P 1700 KW - 25135-51-7 KW - Aluminum KW - CPD4NFA903 KW - Deferoxamine KW - J06Y7MXW4D KW - Index Medicus KW - Humans KW - Aluminum -- adverse effects KW - Aluminum -- blood KW - Deferoxamine -- therapeutic use KW - Renal Dialysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78449260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Rapid+removal+of+DFO-chelated+aluminum+during+hemodialysis+using+polysulfone+dialyzers.&rft.au=Molitoris%2C+B+A%3BAlfrey%2C+A+C%3BAlfrey%2C+P+S%3BMiller%2C+N+L&rft.aulast=Molitoris&rft.aufirst=B&rft.date=1988-07-01&rft.volume=34&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-17 N1 - Date created - 1988-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rebound hypertension during initiation of transdermal clonidine. AN - 78408439; 3416742 AB - Rebound hypertension with a neurological complication occurred during an attempt to substitute transdermal for oral clonidine in a patient with severe hypertension. Published studies have not established an unequivocal correlation between previous oral clonidine dose and the dose of transdermal clonidine required for equally effective antihypertensive therapy. Close observation of blood pressure may be advisable for at least one week following substitution of transdermal for oral clonidine, especially in patients with severe hypertension. JF - Drug intelligence & clinical pharmacy AU - Stewart, M AU - Burris, J F AD - Nursing Home Care Unit, Veterans Administration Medical Center, Washington, DC. PY - 1988 SP - 573 EP - 574 VL - 22 IS - 7-8 SN - 0012-6578, 0012-6578 KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Administration, Oral KW - Administration, Cutaneous KW - Blood Pressure KW - Humans KW - Middle Aged KW - Male KW - Hypertension -- physiopathology KW - Clonidine -- administration & dosage KW - Clonidine -- adverse effects KW - Hypertension -- etiology KW - Clonidine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78408439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+intelligence+%26+clinical+pharmacy&rft.atitle=Rebound+hypertension+during+initiation+of+transdermal+clonidine.&rft.au=Stewart%2C+M%3BBurris%2C+J+F&rft.aulast=Stewart&rft.aufirst=M&rft.date=1988-07-01&rft.volume=22&rft.issue=7-8&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Drug+intelligence+%26+clinical+pharmacy&rft.issn=00126578&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-24 N1 - Date created - 1988-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of retinoids in bone. AN - 78393641; 2970477 AB - Skeletal effects of retinoids on the spine were studied in two clinical trials. In the first study, spinal radiographs of 96 patients who had been treated with isotretinoin for 4 to 9 months were reviewed. The average age of these patients was 25 years, and during treatment or within 2 1/2 years after the end of treatment, 26% of the patients showed progressive formation of small bony spurs consisting of tiny horizontal excrescences that arose at the anterior margin of one or more vertebral bodies adjacent to the intervertebral disk. In a second study, the radiographs of 241 patients with psoriasis who were treated continually for 1 to 2 years with acitretin were examined. Many of these patients had abnormal radiographs at the start of therapy. These preexisting conditions included psoriatic arthritis, degenerative arthritis, and diffuse idiopathic skeletal hyperostosis. Five percent of the patients showed progression of their abnormalities during the study. The difference in the rate of spur formation in the two groups may be due to multiple factors and not simply to retinoid therapy. Because of the extensive amount of preexisting disease in the psoriasis group compared with the relatively normal appearance of the spine in the isotretinoin group, the underlying disease process may be more important than the retinoid therapy. The development of the spinal spurs was not associated with specific clinical symptoms. Since there was no control group, it is unknown whether the spurs would have developed or progressed in the absence of retinoid therapy. JF - Journal of the American Academy of Dermatology AU - Kilcoyne, R F AD - Department of Radiology, Veterans Administration Hospital, San Antonio, TX 78284. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 212 EP - 216 VL - 19 IS - 1 Pt 2 SN - 0190-9622, 0190-9622 KW - Tretinoin KW - 5688UTC01R KW - Isotretinoin KW - EH28UP18IF KW - Acitretin KW - LCH760E9T7 KW - Index Medicus KW - Psoriasis -- physiopathology KW - Humans KW - Adult KW - Time Factors KW - Spinal Diseases -- physiopathology KW - Tretinoin -- analogs & derivatives KW - Spinal Diseases -- chemically induced KW - Tretinoin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78393641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Effects+of+retinoids+in+bone.&rft.au=Kilcoyne%2C+R+F&rft.aulast=Kilcoyne&rft.aufirst=R&rft.date=1988-07-01&rft.volume=19&rft.issue=1+Pt+2&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-11 N1 - Date created - 1988-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methadone maintenance to abstinence. How many make it? AN - 78388201; 3045260 AB - This study imposed a set of decision rules to review and compare methadone maintenance detoxification research results in three 5-year eras since 1970. Variables of interest were detoxification completion rates, relative completion rates with and without program review and approval, psychotherapy, new pharmacological agents to accelerate the detoxification process, and abstinence rates at follow-up as a function of such treatment variables. The review found progressive improvement in overall detoxification completion rates over the three 5-year eras: 39.7%, 54.9%, and 76.3%. Program-recommended detoxification showed much higher completion rates than did unrecommended detoxification in 1970-1975 and psychotherapy-assisted detoxification showed modest but consistently greater completion rates in the two eras during which it was studied, 1970-1975 and 1976-1980. The consistent gains in detoxification completion rates over the three eras are attributed primarily to the use of new drugs which greatly shorten the detoxification interval and ameliorate withdrawal symptoms. The drugs do not appear to have had an effect on follow-up abstinence rates. Limitations upon the conclusions and generalizability of findings are discussed. Suggestions are made for future methadone maintenance detoxification treatment and research. JF - The Journal of nervous and mental disease AU - Milby, J B AD - Psychology Service, Veterans Administration Medical Center, Birmingham, Alabama 35233. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 409 EP - 422 VL - 176 IS - 7 SN - 0022-3018, 0022-3018 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Psychotherapy KW - Humans KW - Prognosis KW - Research Design KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78388201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Methadone+maintenance+to+abstinence.+How+many+make+it%3F&rft.au=Milby%2C+J+B&rft.aulast=Milby&rft.aufirst=J&rft.date=1988-07-01&rft.volume=176&rft.issue=7&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-04 N1 - Date created - 1988-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Native valve endocarditis caused by dysgonic fermenter type 2 bacilli. AN - 78361781; 3407681 AB - A chronic alcoholic who had casual contact with dogs developed subacute tricuspid endocarditis caused by the unusual gram-negative bacillus dysgonic fermenter type 2 (DF-2). Despite recurrent pulmonary emboli, the patient had an apparent successful response to 6 weeks of penicillin therapy. Two weeks after discharge, he experienced congestive heart failure necessitating tricuspid valvulectomy. No evidence of active infection was found in tissue removed at surgery. Despite the achievement of a bacteriologic cure, surgery for residual valve damage is not uncommon in endocarditis, regardless of the microbial etiology. In this case, alcoholism was the only risk factor predisposing to infection presumably contracted from exposure to dogs. JF - The American journal of the medical sciences AU - Niefield, S AU - Young, E J AD - Section of General Medicine, Veterans Administration Medical Center, Houston, TX 77030. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 69 EP - 70 VL - 296 IS - 1 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Tricuspid Valve -- surgery KW - Gram-Negative Aerobic Bacteria -- isolation & purification KW - Risk Factors KW - Humans KW - Dogs KW - Middle Aged KW - Alcoholism -- complications KW - Male KW - Endocarditis, Bacterial -- microbiology KW - Endocarditis, Bacterial -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78361781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Native+valve+endocarditis+caused+by+dysgonic+fermenter+type+2+bacilli.&rft.au=Niefield%2C+S%3BYoung%2C+E+J&rft.aulast=Niefield&rft.aufirst=S&rft.date=1988-07-01&rft.volume=296&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-09 N1 - Date created - 1988-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - P300 latency after ethanol ingestion in sons of alcoholics and in controls. AN - 78346919; 3401524 AB - The magnitude and persistence of ethanol-induced increases in the latency of the P3 event-related potential from auditory stimuli were evaluated in 21 sons of alcoholic fathers (FHP) and 21 control sons of nonalcoholics (FHN) matched on demography and drinking history. The men were assessed at baseline, 70 min after imbibing a beverage, and 240 min after drinking, with observations carried out for each individual in 3 dosage conditions (placebo, 0.75 ml/kg of ethanol, and 1.1 ml/kg of ethanol). There were no family group differences for baseline (prechallenge) P3 latencies, nor any significant group differences after placebo or low-dose ethanol challenges. However, in the high alcohol dose challenge condition, P3 latencies for FHP subjects returned toward baseline measures more quickly than for FHN men. These results are consistent with previous reports of behavioral and biochemical measures in which FHP subjects demonstrated less intense reactions or returned toward baseline conditions more rapidly after ethanol ingestion relative to the FHN controls. JF - Biological psychiatry AU - Schuckit, M A AU - Gold, E O AU - Croot, K AU - Finn, P AU - Polich, J AD - Alcohol Research Center, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 310 EP - 315 VL - 24 IS - 3 SN - 0006-3223, 0006-3223 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Reaction Time -- drug effects KW - Ethanol -- pharmacokinetics KW - Pitch Discrimination -- drug effects KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Evoked Potentials, Auditory -- drug effects KW - Adult KW - Attention -- drug effects KW - Male KW - Arousal -- drug effects KW - Electroencephalography KW - Alcoholism -- genetics KW - Alcohol Drinking -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78346919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=P300+latency+after+ethanol+ingestion+in+sons+of+alcoholics+and+in+controls.&rft.au=Schuckit%2C+M+A%3BGold%2C+E+O%3BCroot%2C+K%3BFinn%2C+P%3BPolich%2C+J&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1988-07-01&rft.volume=24&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-21 N1 - Date created - 1988-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction of ethanol, prostacyclin, and aspirin in determining human platelet reactivity in vitro. AN - 78331722; 2840054 AB - Ethanol partitions into cellular membranes and alters membrane-associated phenomena in numerous cell types. Since platelet aggregation and its inhibition by prostacyclin are mediated by membrane-associated receptors and enzymes, we examined the interaction of ethanol, prostacyclin, and aspirin on human platelet reactivity. Using platelet-rich plasma, we examined the effect of increasing concentrations of ethanol (0.05% to 1.0%) on the platelet-inhibitory effects of a submaximal dose (5 x 10(-10) M) of prostacyclin, the concomitant production of cyclic 3',5'-adenosine monophosphate (AMP), and the release of thromboxane A2. Ethanol alone had little effect on platelet aggregation induced by 5 micrograms/ml collagen; however, it potentiated the inhibitory effect of prostacyclin on platelet aggregation in a dose-dependent manner in the range of 0.05% to 1.0% ethanol. Whereas prostacyclin increased platelet cyclic AMP levels, ethanol had no further effect on cyclic AMP levels. Ethanol alone reduced thromboxane A2 generation, but this effect could not totally account for the observed interaction of ethanol and prostacyclin on aggregation, since aspirin did not totally abolish the interaction. The dose range in which the ethanol/prostacyclin/aspirin interactions occur encompasses the plasma levels of ethanol that may be achieved by the consumption of alcoholic beverages. The results may, in part, explain the dose-related physiological and pathological consequences of chronic alcohol consumption on the cardiovascular system. JF - Arteriosclerosis (Dallas, Tex.) AU - Jakubowski, J A AU - Vaillancourt, R AU - Deykin, D AD - Department of Hemostasis Research, Boston Veterans Administration Medical Center, Massachusetts 02130. PY - 1988 SP - 436 EP - 441 VL - 8 IS - 4 SN - 0276-5047, 0276-5047 KW - Ethanol KW - 3K9958V90M KW - Thromboxane A2 KW - 57576-52-0 KW - Collagen KW - 9007-34-5 KW - Epoprostenol KW - DCR9Z582X0 KW - Cyclic AMP KW - E0399OZS9N KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Cyclic AMP -- biosynthesis KW - Drug Interactions KW - Thromboxane A2 -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Blood Platelets -- drug effects KW - In Vitro Techniques KW - Collagen -- pharmacology KW - Blood Platelets -- metabolism KW - Epoprostenol -- pharmacology KW - Ethanol -- pharmacology KW - Platelet Aggregation -- drug effects KW - Aspirin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78331722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis+%28Dallas%2C+Tex.%29&rft.atitle=Interaction+of+ethanol%2C+prostacyclin%2C+and+aspirin+in+determining+human+platelet+reactivity+in+vitro.&rft.au=Jakubowski%2C+J+A%3BVaillancourt%2C+R%3BDeykin%2C+D&rft.aulast=Jakubowski&rft.aufirst=J&rft.date=1988-07-01&rft.volume=8&rft.issue=4&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis+%28Dallas%2C+Tex.%29&rft.issn=02765047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-18 N1 - Date created - 1988-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mild hypertension, diuretics, and cardiac arrhythmias: consensus amid controversy? AN - 78323028; 3293390 JF - American heart journal AU - Khair, G Z AU - Kochar, M S AD - Medical Service, Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 216 EP - 221 VL - 116 IS - 1 Pt 1 SN - 0002-8703, 0002-8703 KW - Benzothiadiazines KW - 0 KW - Diuretics KW - Sodium Chloride Symporter Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Hypokalemia -- chemically induced KW - Risk Factors KW - Humans KW - Blood Pressure -- drug effects KW - Sodium Chloride Symporter Inhibitors -- therapeutic use KW - Hypertension -- complications KW - Arrhythmias, Cardiac -- chemically induced KW - Sodium Chloride Symporter Inhibitors -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78323028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Mild+hypertension%2C+diuretics%2C+and+cardiac+arrhythmias%3A+consensus+amid+controversy%3F&rft.au=Khair%2C+G+Z%3BKochar%2C+M+S&rft.aulast=Khair&rft.aufirst=G&rft.date=1988-07-01&rft.volume=116&rft.issue=1+Pt+1&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-12 N1 - Date created - 1988-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Allopurinol and lodoxamide in complement-induced hepatic ischemia. AN - 78320275; 3260642 AB - Intravascular complement activation with either zymosan or cobra venom factor (CVF) impairs hepatic blood flow. Oxygen radical scavengers given at the time of complement activation attenuate the resulting hepatic ischemia. It is not clear whether complement-stimulated phagocytes or transiently ischemic then reperfused endothelial and parenchymal cells generated the toxic oxygen radicals. In this study, a group of rats were given allopurinol (50 mg/kg/day postoperatively X 3 days plus 100 mg/kg iv at t = 0), a specific inhibitor of xanthine oxidase, prior to complement activation with CVF (20 units/kg iv at t = 30 and 60 min) to determine whether xanthine oxidase-derived oxygen radicals contributed significantly to the hepatic perfusion abnormalities. Additional rats received lodoxamide tromethamine (10 mg/kg iv bolus at t = 0 followed by 20 mg/kg/hr iv infusion), a novel and potent inhibitor of mast cell release and inhibitor of xanthine oxidase, prior to the same CVF challenge to determine whether mast cell mediators were involved in the flow disturbance. Thermodilution cardiac output, mean arterial pressure, heart rate, hematocrit, and effective hepatic blood flow (EHBF) by galactose clearance were determined at t = 2 hr. The percentage change in total hemolytic complement activity (% delta CH50) was determined between serum obtained prior to sacrifice and at t = 0. Systemic hemodynamics and HCT were for the most part unaffected regardless of pretreatment group or challenge with CVF or saline. CVF challenge produced a 25% reduction (P less than 0.05) in EHBF in vehicle-pretreated rats compared to saline challenge. Neither allopurinol nor lodoxamide tromethamine significantly improved EHBF when given prior to CVF challenge.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of surgical research AU - Schirmer, W J AU - Schirmer, J M AU - Naff, G B AU - Fry, D E AD - Department of Surgery, Veterans Administration Medical Center, Case Western Reserve University Hospitals, Cleveland, Ohio 44106. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 28 EP - 36 VL - 45 IS - 1 SN - 0022-4804, 0022-4804 KW - Amino Acids KW - 0 KW - Cobra Venoms KW - Nitriles KW - Tromethamine KW - 023C2WHX2V KW - lodoxamide tromethamine KW - 50LV9A548L KW - Allopurinol KW - 63CZ7GJN5I KW - Complement System Proteins KW - 9007-36-7 KW - Oxamic Acid KW - QU60N5OPLG KW - Index Medicus KW - Animals KW - Cobra Venoms -- pharmacology KW - Hemodynamics KW - Complement Activation KW - Allopurinol -- pharmacology KW - Ischemia -- etiology KW - Complement System Proteins -- physiology KW - Oxamic Acid -- pharmacology KW - Oxamic Acid -- analogs & derivatives KW - Ischemia -- physiopathology KW - Complement System Proteins -- analysis KW - Ischemia -- chemically induced KW - Amino Acids -- pharmacology KW - Liver Circulation -- drug effects KW - Tromethamine -- analogs & derivatives KW - Tromethamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78320275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Allopurinol+and+lodoxamide+in+complement-induced+hepatic+ischemia.&rft.au=Schirmer%2C+W+J%3BSchirmer%2C+J+M%3BNaff%2C+G+B%3BFry%2C+D+E&rft.aulast=Schirmer&rft.aufirst=W&rft.date=1988-07-01&rft.volume=45&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-22 N1 - Date created - 1988-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - What price success? The continuing saga of the toxic:therapeutic ratio in the use of aminoglycoside antibiotics. AN - 78312259; 3292658 JF - The Journal of infectious diseases AU - John, J F AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 1 EP - 6 VL - 158 IS - 1 SN - 0022-1899, 0022-1899 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Abridged Index Medicus KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Anti-Bacterial Agents -- adverse effects KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78312259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=What+price+success%3F+The+continuing+saga+of+the+toxic%3Atherapeutic+ratio+in+the+use+of+aminoglycoside+antibiotics.&rft.au=John%2C+J+F&rft.aulast=John&rft.aufirst=J&rft.date=1988-07-01&rft.volume=158&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-17 N1 - Date created - 1988-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis. AN - 78309892; 3391508 AB - We have shown, using the proline:ornithine dual label method, that in normal rats, hepatocytes contribute in vivo about 80 to 90% of the newly synthesized hepatic collagen. In order to quantify the contribution of hepatocytes and nonparenchymal cells to collagen synthesis in vivo in hepatic fibrogenesis, rats with CCl4-induced liver fibrosis were given [5(3H)]proline and [14C]ornithine intraperitoneally. About 80% of the 14C in albumin and transferrin was present as arginine, following conversion of [14C]ornithine via the urea cycle. In contrast to hepatocyte proteins, in nonparenchymal cells and serum a negligible percentage of the radioactivity was present as [14C]arginine. These combined findings indicate that, in spite of the hepatocellular damage, the labeling of hepatocyte proteins was efficient and specific, validating the use of the proline:ornithine method in this experimental model of hepatic fibrosis. We calculated the [3H]proline/[14C]arginine ratio in hepatic collagen (after correcting for the relative frequencies of amino acids) as a percentage of the same ratio in either albumin or transferrin, the index hepatocyte proteins. In this experimental model, during active fibrogenesis, both hepatocytes and nonparenchymal cells increase their production of collagen 2-fold when compared to normal animals, and hepatocytes produce the majority of the newly synthesized hepatic collagen. JF - Hepatology (Baltimore, Md.) AU - Chojkier, M AU - Lyche, K D AU - Filip, M AD - Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161. PY - 1988 SP - 808 EP - 814 VL - 8 IS - 4 SN - 0270-9139, 0270-9139 KW - Collagen KW - 9007-34-5 KW - Arginine KW - 94ZLA3W45F KW - Proline KW - 9DLQ4CIU6V KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Proline -- metabolism KW - Arginine -- metabolism KW - Carbon Tetrachloride -- toxicity KW - Male KW - Liver Cirrhosis, Experimental -- chemically induced KW - Liver -- pathology KW - Liver -- metabolism KW - Liver Cirrhosis, Experimental -- metabolism KW - Collagen -- biosynthesis KW - Liver Cirrhosis, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78309892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Increased+production+of+collagen+in+vivo+by+hepatocytes+and+nonparenchymal+cells+in+rats+with+carbon+tetrachloride-induced+hepatic+fibrosis.&rft.au=Chojkier%2C+M%3BLyche%2C+K+D%3BFilip%2C+M&rft.aulast=Chojkier&rft.aufirst=M&rft.date=1988-07-01&rft.volume=8&rft.issue=4&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-25 N1 - Date created - 1988-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Improved acanthosis nigricans with lipodystrophic diabetes during dietary fish oil supplementation. AN - 78303267; 3389852 AB - Acanthosis nigricans is well recognized in its clinical association with several types of insulin-resistant syndromes, and skin involvement is usually unresponsive to local treatment or management of diabetes. A young woman with a lipodystrophic form of diabetes, hypertriglyceridemia, and severe generalized acanthosis nigricans was placed on a diet with fat supplementation in the form of omega-3-fatty-acid-rich fish oil. She was observed to have striking improvement in the appearance and extent of acanthosis nigricans while receiving this regimen. This occurred despite continued therapy with niacin (nicotinic acid), an agent associated with acanthosis nigricanslike skin changes. JF - Archives of dermatology AU - Sherertz, E F AD - Veterans Administration Medical Center, Gainesville. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 1094 EP - 1096 VL - 124 IS - 7 SN - 0003-987X, 0003-987X KW - Fish Oils KW - 0 KW - Triglycerides KW - Niacin KW - 2679MF687A KW - Abridged Index Medicus KW - Index Medicus KW - Triglycerides -- blood KW - Niacin -- adverse effects KW - Humans KW - Adolescent KW - Female KW - Niacin -- therapeutic use KW - Acanthosis Nigricans -- drug therapy KW - Acanthosis Nigricans -- complications KW - Diabetes Mellitus, Lipoatrophic -- complications KW - Acanthosis Nigricans -- chemically induced KW - Diabetes Mellitus, Lipoatrophic -- drug therapy KW - Fish Oils -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78303267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Improved+acanthosis+nigricans+with+lipodystrophic+diabetes+during+dietary+fish+oil+supplementation.&rft.au=Sherertz%2C+E+F&rft.aulast=Sherertz&rft.aufirst=E&rft.date=1988-07-01&rft.volume=124&rft.issue=7&rft.spage=1094&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-02 N1 - Date created - 1988-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicology screening. How to assure accurate results. AN - 78297266; 3387349 JF - Postgraduate medicine AU - Mullen, J AU - Bracha, H S AD - Psychiatry Service, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 141 EP - 148 VL - 84 IS - 1 SN - 0032-5481, 0032-5481 KW - Street Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - False Negative Reactions KW - Humans KW - False Positive Reactions KW - Street Drugs -- pharmacokinetics KW - Substance-Related Disorders -- diagnosis KW - Street Drugs -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78297266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Toxicology+screening.+How+to+assure+accurate+results.&rft.au=Mullen%2C+J%3BBracha%2C+H+S&rft.aulast=Mullen&rft.aufirst=J&rft.date=1988-07-01&rft.volume=84&rft.issue=1&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-05 N1 - Date created - 1988-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The portal hypertensive gastric mucosa: histologic, ultrastructural, and functional analysis after aspirin-induced damage. AN - 78294111; 3388181 AB - We assessed macroscopic, histologic, ultrastructural, and functional features of aspirin-induced gastric mucosal injury in portal hypertensive and sham-operated rats. Portal hypertension was produced by staged portal vein ligation. Four hours after intragastric acidified aspirin administration, intraluminal pH in portal hypertensive rats was 6.6 +/- 0.2 and 4.3 +/- 0.5 in sham-operated controls (p less than 0.01). Gross mucosal damage was significantly greater in portal hypertensive rats compared with controls (18 +/- 2 versus 7 +/- 1% of total mucosal area). Histologic deep necrosis involved 22 +/- 2% of mucosal section lengths in portal hypertensive rats compared with 7 +/- 1% in sham-operated rats (p less than 0.01). In portal hypertensive rats, histologic and ultrastructural evaluation demonstrated capillary endothelial abnormalities, arterialization of submucosal veins, and markedly greater severity of microvascular damage than in sham-operated controls. Neutralized aspirin (pH, 7.0) did not produce any significant damage detectable grossly, histologically, or by transmission electron microscopy in portal hypertensive rats. We conclude that acid-dependent aspirin-induced gastric mucosal damage is significantly increased in portal hypertension. JF - Surgery AU - Sarfeh, I J AU - Tarnawski, A AU - Hajduczek, A AU - Stachura, J AU - Bui, H X AU - Krause, W J AD - Department of Surgery, Long Beach Veterans Administration Medical Center, Irvine, Calif. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 79 EP - 85 VL - 104 IS - 1 SN - 0039-6060, 0039-6060 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Hydrogen-Ion Concentration KW - Microscopy, Electron KW - Male KW - Microscopy, Electron, Scanning KW - Gastric Acid -- secretion KW - Gastritis -- pathology KW - Hypertension, Portal -- pathology KW - Gastric Mucosa -- ultrastructure KW - Gastric Mucosa -- secretion KW - Gastritis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78294111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery&rft.atitle=The+portal+hypertensive+gastric+mucosa%3A+histologic%2C+ultrastructural%2C+and+functional+analysis+after+aspirin-induced+damage.&rft.au=Sarfeh%2C+I+J%3BTarnawski%2C+A%3BHajduczek%2C+A%3BStachura%2C+J%3BBui%2C+H+X%3BKrause%2C+W+J&rft.aulast=Sarfeh&rft.aufirst=I&rft.date=1988-07-01&rft.volume=104&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Surgery&rft.issn=00396060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reduction in the toxicity of a component of an artificial blood substitute by supercritical fluid fractionation. AN - 78293434; 3388483 AB - Artificial blood substitutes (ABS) containing the surfactant Pluronic F68 (F68) are reported to be cytotoxic to cell lines. Because of F68's reported impairment of granulocyte function, it was hypothesized that F68 was also responsible for the cytotoxicity of ABS, possibly as a result of a separable fraction of the F68, separation of which could be achieved using supercritical fluid fractionation (SFF). SFF employs gases, such as carbon dioxide, under high pressure to dissolve the parent compound, a process that is followed by step-by-step precipitation and recovery of the dissolved material. The toxicity of F68 to human and animal cells was investigated by culturing Hela and B16 cells in the presence or absence of F68. Cells were grown for 4 days, harvested, and counted. Hela and B16 growth were markedly inhibited by F68. Four lots of F68 at 20 mg per ml inhibited Hela growth by 54 +/- 10 percent (p less than 0.05). In four dose-response experiments, three lots of F68 caused 50 percent inhibition of cell growth at 25 +/- 17 mg per ml. Four lots of F68 were also processed by SFF. Hela cells were grown in the presence of control media, parent (unextracted) F68, the early fractions of SFF extraction (XT), and the residual (partially purified) (RES F68). All parent F68, XT, and RES F68 were at 20 mg per ml. In 11 studies, the XT were 77 +/- 25 percent more toxic than the parent F68 (p less than 0.02), and the RES F68 were 30 +/- 11 percent less toxic than parent F68 (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Transfusion AU - Lane, T A AU - Krukonis, V AD - Department of Pathology, Veterans Administration Medical Center, San Diego, California. PY - 1988 SP - 375 EP - 378 VL - 28 IS - 4 SN - 0041-1132, 0041-1132 KW - Blood Substitutes KW - 0 KW - Drug Combinations KW - Fluorocarbons KW - Hydroxyethyl Starch Derivatives KW - glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination KW - 75216-20-5 KW - Index Medicus KW - Animals KW - HeLa Cells -- drug effects KW - Humans KW - Drug Combinations -- toxicity KW - Chemical Fractionation -- methods KW - Fluorocarbons -- toxicity KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78293434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Reduction+in+the+toxicity+of+a+component+of+an+artificial+blood+substitute+by+supercritical+fluid+fractionation.&rft.au=Lane%2C+T+A%3BKrukonis%2C+V&rft.aulast=Lane&rft.aufirst=T&rft.date=1988-07-01&rft.volume=28&rft.issue=4&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-11 N1 - Date created - 1988-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics of bradykinin and TPA increases in the PGE2 levels of human urothelial cells. AN - 78266905; 3133127 AB - Prostaglandins play a potential key role in the pathogenesis of urinary bladder cancer. Bradykinin and TPA increases in prostaglandin (PG)E2 levels were compared in primary cultures of human urothelial cells. Increased PGE2 levels were dependent upon the dose of TPA and were not apparent until 30-60 min after addition of TPA, with larger increases occurring between 60 and 120 min. Stimulation was inhibited by cycloheximide. Addition of arachidonic acid to TPA-stimulated cells increased PGE2 to a level similar to that seen in arachidonic acid-stimulated controls, and this level was not altered by cycloheximide. In contrast to TPA, the bradykinin-increased PGE2 levels were maximal at 5 min (the earliest time-point assessed) and were not inhibited by cycloheximide. Increases in PGE2 levels by both TPA and bradykinin required calcium. Excessive stimulation by TPA resulted in a desensitization to subsequent stimulation by TPA, but not bradykinin. Combination of TPA with bradykinin produced at least an additive effect on PGE2 levels. Both agonists increased the release of [3H]arachidonic acid over a time-course similar to their PGE2 response. Bradykinin and TPA appear to increase PGE2 levels by enhancing arachidonic acid availability through separate phospholipase pathways. Thus, human urothelial cells exhibit similar, but yet distinct profiles for prostaglandin stimulation by TPA and bradykinin. JF - Carcinogenesis AU - Zenser, T V AU - Thomasson, D L AU - Davis, B B AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St Louis, MO 63125. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 1173 EP - 1177 VL - 9 IS - 7 SN - 0143-3334, 0143-3334 KW - Arachidonic Acids KW - 0 KW - Prostaglandins E KW - Arachidonic Acid KW - 27YG812J1I KW - Cycloheximide KW - 98600C0908 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Bradykinin KW - S8TIM42R2W KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Cycloheximide -- pharmacology KW - In Vitro Techniques KW - Calcium -- physiology KW - Epithelium -- metabolism KW - Arachidonic Acids -- metabolism KW - Ureter -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Bradykinin -- pharmacology KW - Ureter -- cytology KW - Prostaglandins E -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78266905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Characteristics+of+bradykinin+and+TPA+increases+in+the+PGE2+levels+of+human+urothelial+cells.&rft.au=Zenser%2C+T+V%3BThomasson%2C+D+L%3BDavis%2C+B+B&rft.aulast=Zenser&rft.aufirst=T&rft.date=1988-07-01&rft.volume=9&rft.issue=7&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-03 N1 - Date created - 1988-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diagnosis and course of nephrogenic ascites. AN - 78264942; 2968075 AB - Nephrogenic ascites is a complex diagnostic problem with poorly understood pathophysiology. Morbidity and eventual mortality from this ongoing problem are significant. The diagnosis of nephrogenic ascites must be established by exclusion. We report the cases of nine patients investigated between 1978 and 1985. Laparoscopy, which was utilized in all nine patients, led to a specific diagnosis in two. We believe that a vigorous diagnostic evaluation, including laparoscopy, is essential in patients with chronic renal failure who develop persistent ascites. JF - Archives of internal medicine AU - Mauk, P M AU - Schwartz, J T AU - Lowe, J E AU - Smith, J L AU - Graham, D Y AD - Department of Medicine, Veterans Administration Medical Center, Houston, TX 77030. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 1577 EP - 1579 VL - 148 IS - 7 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Peritonitis, Tuberculous -- diagnosis KW - Laparoscopy KW - Combined Modality Therapy KW - Humans KW - Peritoneal Dialysis KW - Adult KW - Middle Aged KW - Renal Dialysis KW - Liver Cirrhosis, Alcoholic -- diagnosis KW - Male KW - Ascites -- etiology KW - Ascites -- therapy KW - Kidney Failure, Chronic -- complications KW - Ascites -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78264942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Diagnosis+and+course+of+nephrogenic+ascites.&rft.au=Mauk%2C+P+M%3BSchwartz%2C+J+T%3BLowe%2C+J+E%3BSmith%2C+J+L%3BGraham%2C+D+Y&rft.aulast=Mauk&rft.aufirst=P&rft.date=1988-07-01&rft.volume=148&rft.issue=7&rft.spage=1577&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-26 N1 - Date created - 1988-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intragastric accumulation of Evan's blue as a method for assessing aspirin-induced acute gastric mucosal injury in humans. AN - 78259478; 3259918 AB - Aspirin administration results in gastric mucosal damage. Although the pathogenesis of these lesions remains unclear, in animals it appears that increased vascular permeability precedes development of grossly visible lesions. We examined the effect of aspirin administration on gastric vascular permeability in eight healthy subjects. We used gastric accumulation of Evan's blue dye (which is bound to albumin) as a marker of vascular integrity and assessed gastric accumulation of Evan's blue, blood, and DNA during serial 10-min washes. Both bleeding and Evan's blue in the gastric washings increased with time after administration of aspirin in an acid solution (P less than 0.01). Evan's blue increased from a median value of 8 micrograms/10 min to 24.5 micrograms/10 min period after 60 min of aspirin administration. By 20 min after aspirin administration, the accumulation of Evan's blue in the gastric wash was significantly greater than the initial aspirin period (P less than 0.05). Blood loss increased from 147 to 650 micrograms Hgb/10-min period. The increase in bleeding rate did not become significant until 40 min after the first aspirin dose. Our study showed that aspirin-induced gastric mucosal damage can be detected by assessing accumulation of Evan's blue in the gastric contents after aspirin administration. Studies in which various doses of aspirin or other agents are administered will be required to confirm whether the increased vascular permeability actually precedes bleeding in man. Measurement of Evan's blue dye in the gastric contents appears to provide a qualitative (and possibly quantitative) and sensitive early index of gastric mucosal injury. JF - Digestive diseases and sciences AU - Woods, K L AU - Smith, J L AU - Graham, D Y AD - Digestive Disease Section, Veterans Administration Medical Center, Houston, Texas 77211. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 769 EP - 773 VL - 33 IS - 7 SN - 0163-2116, 0163-2116 KW - Azo Compounds KW - 0 KW - Evans Blue KW - 45PG892GO1 KW - DNA KW - 9007-49-2 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Gastric Juice -- analysis KW - DNA -- analysis KW - Capillary Permeability -- drug effects KW - Gastrointestinal Contents -- analysis KW - Male KW - Female KW - Aspirin -- toxicity KW - Aspirin -- pharmacokinetics KW - Gastric Mucosa -- drug effects KW - Gastrointestinal Hemorrhage -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78259478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+accumulation+of+Evan%27s+blue+as+a+method+for+assessing+aspirin-induced+acute+gastric+mucosal+injury+in+humans.&rft.au=Woods%2C+K+L%3BSmith%2C+J+L%3BGraham%2C+D+Y&rft.aulast=Woods&rft.aufirst=K&rft.date=1988-07-01&rft.volume=33&rft.issue=7&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-28 N1 - Date created - 1988-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-C. AN - 78257541; 3289895 AB - Both insulin and phorbol esters rapidly stimulated the cytoplasmic accumulation of a specific mRNA (designated p33) in a time- and dose-dependent manner in serum-deprived rat H4 hepatoma cells. When cells were pretreated with phorbol esters to produce a deficiency in protein kinase-C, the ability of further phorbol ester addition to stimulate p33 mRNA accumulation was abolished. However, after pretreatment of H4 cells with phorbol esters, insulin still induced cellular p33 mRNA concentrations, but to a lesser degree. The primary effect of phorbol esters was to increase transcription of the p33 gene, and this was abolished after pretreatment with phorbol esters. In previous work, insulin was shown to stimulate p33 gene transcription, but this effect was insufficient to account for the level of insulin-induced p33 mRNA production. The transcriptional effect of insulin was further reduced by phorbol ester pretreatment. Insulin must, therefore, regulate p33 gene expression by at least two pathways, at least one of which may be modulated by protein kinase-C. JF - Endocrinology AU - Weinstock, R S AU - Messina, J L AD - Veterans Administration Medical Center, Syracuse, New York 13210. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 366 EP - 372 VL - 123 IS - 1 SN - 0013-7227, 0013-7227 KW - Insulin KW - 0 KW - RNA, Messenger KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Cell Nucleus -- metabolism KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Nucleus -- drug effects KW - Transcription, Genetic -- drug effects KW - Liver Neoplasms, Experimental -- metabolism KW - RNA, Messenger -- drug effects KW - Insulin -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Protein Kinase C -- physiology KW - RNA, Messenger -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78257541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Transcriptional+regulation+of+a+rat+hepatoma+gene+by+insulin+and+protein+kinase-C.&rft.au=Weinstock%2C+R+S%3BMessina%2C+J+L&rft.aulast=Weinstock&rft.aufirst=R&rft.date=1988-07-01&rft.volume=123&rft.issue=1&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-29 N1 - Date created - 1988-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Should asymptomatic ventricular arrhythmias in patients with congestive heart failure be treated with antiarrhythmic drugs? AN - 78252888; 3288678 JF - Journal of the American College of Cardiology AU - Francis, G S AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 274 EP - 283 VL - 12 IS - 1 SN - 0735-1097, 0735-1097 KW - Anti-Arrhythmia Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Arrhythmias, Cardiac -- complications KW - Heart Failure -- complications KW - Arrhythmias, Cardiac -- drug therapy KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78252888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Should+asymptomatic+ventricular+arrhythmias+in+patients+with+congestive+heart+failure+be+treated+with+antiarrhythmic+drugs%3F&rft.au=Francis%2C+G+S&rft.aulast=Francis&rft.aufirst=G&rft.date=1988-07-01&rft.volume=12&rft.issue=1&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-22 N1 - Date created - 1988-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Performance Standards for Social Workers AN - 61557451; 198801044 AB - Since 1981, Veterans Administration medical centers (VAMCs) have been required to implement performance standards against which employees' direct patient care, documentation, & professional relationships/responsibilities can be evaluated. Using Likert-type questionnaires, social work staff & their supervisors/administrators (N = 78) at 6 VAMCs in the northeastern US reported their perceptions of the purpose, use, & relevance of the performance standard appraisal process, & suggested modifications. Significant differences were revealed between the two groups; several explanations for this are offered. Recommendations are made concerning how supervisors can use performance standards as a management tool. 5 Tables, 1 Figure. Modified HA JF - Social Work AU - Harkness, Laurie AU - Mulinski, Paul AD - Community Psychiatry Program Veterans Administration Medical Center, West Haven CT 06510 Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 339 EP - 344 VL - 33 IS - 4 SN - 0037-8046, 0037-8046 KW - performance standard appraisal process, social work staff, Veterans Administration medical centers KW - questionnaires KW - US KW - Evaluation KW - Social Workers KW - United States of America KW - Performance KW - Hospitals KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61557451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work&rft.atitle=Performance+Standards+for+Social+Workers&rft.au=Harkness%2C+Laurie%3BMulinski%2C+Paul&rft.aulast=Harkness&rft.aufirst=Laurie&rft.date=1988-07-01&rft.volume=33&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Social+Work&rft.issn=00378046&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States of America; Hospitals; Social Workers; Performance; Evaluation ER - TY - JOUR T1 - Phonological Factors in Lexical Access: Evidence from an Auditory Lexical Decision Task AN - 58185866; 8807163 AB - A group of Ss (N = 12) performed a lexical decision task in which target words were preceded by a number of different prime types: semantically related words, nonwords in which the initial phoneme of the semantically related word was distorted by one phonetic feature, & unrelated words. The results showed a monotonic relationship between phonetic distortion & lexical decision facilitation. Lexical access appears to take into account possible noise or distortion of the speech signal, so that a nonword stimulus that is phonetically related to an actual lexical entry is, in some sense, "normalized" & processed as an actual lexical entry. 2 Figures, 15 References. HA JF - The Bulletin of the Psychonomic Society AU - Milberg, William AU - Blumstein, Sheila AU - Dworetzky, Barbara AD - Geriatric Research/Education/Clinical Center Veterans Administration Medical Center, 1400 VFW Parkway West Roxbury MA 02132 Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 305 EP - 308 VL - 26 IS - 4 SN - 0090-5054, 0090-5054 KW - lexical access, phonological factors KW - auditory lexical decision task data KW - Auditory Stimulation (au7) KW - Verbal Task (ve3) KW - Memory (me3) KW - Cognitive Processes (co1b) KW - Verbal Learning (ve2) KW - Phonology (ph13) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58185866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Bulletin+of+the+Psychonomic+Society&rft.atitle=Phonological+Factors+in+Lexical+Access%3A+Evidence+from+an+Auditory+Lexical+Decision+Task&rft.au=Milberg%2C+William%3BBlumstein%2C+Sheila%3BDworetzky%2C+Barbara&rft.aulast=Milberg&rft.aufirst=William&rft.date=1988-07-01&rft.volume=26&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=The+Bulletin+of+the+Psychonomic+Society&rft.issn=00905054&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BPNSBY N1 - SubjectsTermNotLitGenreText - Cognitive Processes (co1b); Verbal Learning (ve2); Verbal Task (ve3); Phonology (ph13); Auditory Stimulation (au7); Memory (me3) ER - TY - JOUR T1 - Generalized seizures deplete brain energy reserves in normoxemic newborn monkeys. AN - 78393035; 3136858 AB - The cerebral metabolic response to bicuculline (BC)-induced status epilepticus (SE) was studied in two-week-old ketamine-anesthetized marmoset monkeys. During 30-min clonic seizures, mean blood pressure, plasma glucose and paO2 did not decrease and plasma lactate doubled. Brains were funnel-frozen and punch biopsies of frontoparietal cortex, temporal cortex and thalamus were analyzed for ATP, phosphocreatine (PCr), glucose and lactate. There were marked reductions of ATP (to 56-77% of controls), PCr (to 23-28% of controls) and glucose (to 1-4% of controls), and lactate increased 3- to 6-fold in seizure animals. NADH fluorescence increased during seizures in cerebral cortex, thalamus, amygdaloid nuclei, hippocampus, posterior striatum and hemispheric white matter. This suggests a reduced tissue redox state in these regions and is correlated with the high energy phosphate depletion and elevated lactate in cortex and thalamus. Our results demonstrate a significant depletion of energy reserves and glucose in cerebral cortex and thalamus during neonatal seizures in the absence of adverse systemic factors. These seizure-induced metabolic changes in brain could have adverse long-term effects on brain development and function. JF - Brain research AU - Fujikawa, D G AU - Vannucci, R C AU - Dwyer, B E AU - Wasterlain, C G AD - Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1988/06/28/ PY - 1988 DA - 1988 Jun 28 SP - 51 EP - 59 VL - 454 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Lactates KW - 0 KW - Phosphocreatine KW - 020IUV4N33 KW - NAD KW - 0U46U6E8UK KW - Lactic Acid KW - 33X04XA5AT KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Glucose KW - IY9XDZ35W2 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - NAD -- metabolism KW - Animals KW - Lactates -- metabolism KW - Glucose -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Phosphocreatine -- metabolism KW - Seizures -- chemically induced KW - Brain -- physiopathology KW - Callitrichinae -- physiology KW - Seizures -- metabolism KW - Brain -- metabolism KW - Energy Metabolism KW - Animals, Newborn -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78393035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Generalized+seizures+deplete+brain+energy+reserves+in+normoxemic+newborn+monkeys.&rft.au=Fujikawa%2C+D+G%3BVannucci%2C+R+C%3BDwyer%2C+B+E%3BWasterlain%2C+C+G&rft.aulast=Fujikawa&rft.aufirst=D&rft.date=1988-06-28&rft.volume=454&rft.issue=1-2&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-11 N1 - Date created - 1988-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine. AN - 78391233; 2970277 AB - The binding of [3H]cyanoimipramine to serotonin uptake sites in rat brain slices was studied using quantitative autoradiography. Binding was of high affinity and was to a single class of binding site. This is in contrast to results previously obtained by others with [3H]imipramine where two binding sites were observed. The sites labeled by [3H]cyanoimipramine had properties consistent with this ligand labeling serotonin uptake sites, as: (1) binding is displaced by drugs which are potent inhibitors of serotonin uptake but not by drugs which are weak inhibitors of uptake; (2) binding is dependent on the presence of sodium ions as is the uptake of serotonin; (3) binding is almost completely eliminated in the brains of rats lesioned by the serotonin neurotoxin 5,7-dihydroxytryptamine; (4) the distribution of binding sites throughout the rat brain is highly correlated with that found previously for [3H]indalpine, a potent serotonin uptake inhibitor, and for [3H]imipramine. The properties of binding of [3H]cyanoimipramine make it an ideal ligand for the quantitative autoradiography of serotonin uptake sites. JF - Brain research AU - Kovachich, G B AU - Aronson, C E AU - Brunswick, D J AU - Frazer, A AD - Neuropsychopharmacology Unit, Veterans Administration Medical Center, Philadelphia, PA 19104. Y1 - 1988/06/28/ PY - 1988 DA - 1988 Jun 28 SP - 78 EP - 88 VL - 454 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Receptors, Serotonin KW - 0 KW - Fluoxetine KW - 01K63SUP8D KW - cianopramine KW - 02MNR4P2PM KW - Zimeldine KW - 3J928617DW KW - norzimelidine KW - 56775-85-0 KW - 1-Naphthylamine KW - 9753I242R5 KW - Imipramine KW - OGG85SX4E4 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Animals KW - 1-Naphthylamine -- metabolism KW - Fluoxetine -- metabolism KW - Autoradiography KW - Rats KW - Rats, Inbred Strains KW - Zimeldine -- metabolism KW - 1-Naphthylamine -- analogs & derivatives KW - Zimeldine -- analogs & derivatives KW - Kinetics KW - Binding, Competitive KW - Male KW - Imipramine -- analogs & derivatives KW - Imipramine -- metabolism KW - Brain -- metabolism KW - Receptors, Serotonin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78391233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Quantitative+autoradiography+of+serotonin+uptake+sites+in+rat+brain+using+%5B3H%5Dcyanoimipramine.&rft.au=Kovachich%2C+G+B%3BAronson%2C+C+E%3BBrunswick%2C+D+J%3BFrazer%2C+A&rft.aulast=Kovachich&rft.aufirst=G&rft.date=1988-06-28&rft.volume=454&rft.issue=1-2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-11 N1 - Date created - 1988-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hair cell regeneration after acoustic trauma in adult Coturnix quail. AN - 78265997; 3381101 AB - Recovery of hair cells was studied at various times after acoustic trauma in adult quail. An initial loss of hair cells recovered to within 5 percent of the original number of cells. Tritium-labeled thymidine was injected after this acoustic trauma to determine if mitosis played a role in recovery of hair cells. Within 10 days of acoustic trauma, incorporation of [3H]thymidine was seen over the nuclei of hair cells and supporting cells in the region of initial hair cell loss. Thus, hair cell regeneration can occur after embryonic terminal mitosis. JF - Science (New York, N.Y.) AU - Ryals, B M AU - Rubel, E W AD - Audiology and Speech Pathology, Veterans Administration Medical Center, Richmond, VA 23249. Y1 - 1988/06/24/ PY - 1988 DA - 1988 Jun 24 SP - 1774 EP - 1776 VL - 240 IS - 4860 SN - 0036-8075, 0036-8075 KW - Index Medicus KW - Animals KW - Age Factors KW - Coturnix KW - Time Factors KW - DNA Replication KW - Cell Division KW - Hearing Loss, Noise-Induced -- physiopathology KW - Hair Cells, Auditory -- physiology KW - Hair Cells, Auditory -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78265997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Hair+cell+regeneration+after+acoustic+trauma+in+adult+Coturnix+quail.&rft.au=Ryals%2C+B+M%3BRubel%2C+E+W&rft.aulast=Ryals&rft.aufirst=B&rft.date=1988-06-24&rft.volume=240&rft.issue=4860&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-20 N1 - Date created - 1988-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of calcium antagonists as initial pharmacologic monotherapy for systemic hypertension in patients over 60 years of age. AN - 78258129; 3289345 AB - Hypertension is most prevalent in older patients and is associated with increasing morbidity and mortality with age. The ability of antihypertensive treatment to reduce these complications in the elderly is now well established. However, several aspects of the treatment of hypertension are being evaluated. In particular, there is a growing trend to avoid individualizing the choice of medication. This is of particular concern in older patients who may differ in the pathophysiology of their hypertension, in their accompanying medical conditions, and in how they may respond to antihypertensive drugs. In addition, elderly hypertensives are often taking a number of medications in addition to antihypertensive drugs. This, along with the fact that the elderly often metabolize drugs more slowly, makes this group particularly susceptible to drug-drug interactions and pharmacologically induced toxic side effects. Considering these points, it appears that the calcium channel blockers are attractive antihypertensive agents for the elderly population. JF - The American journal of cardiology AU - Giles, T D AU - Massie, B M AD - Department of Medical Service, Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1988/06/15/ PY - 1988 DA - 1988 Jun 15 SP - 13H EP - 17H VL - 61 IS - 16 SN - 0002-9149, 0002-9149 KW - Calcium Channel Blockers KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Drug Interactions KW - Humans KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Hypertension -- physiopathology KW - Calcium Channel Blockers -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78258129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Role+of+calcium+antagonists+as+initial+pharmacologic+monotherapy+for+systemic+hypertension+in+patients+over+60+years+of+age.&rft.au=Giles%2C+T+D%3BMassie%2C+B+M&rft.aulast=Giles&rft.aufirst=T&rft.date=1988-06-15&rft.volume=61&rft.issue=16&rft.spage=13H&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-15 N1 - Date created - 1988-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of irradiation on alaryngeal voice of totally laryngectomized patients. AN - 85282009; pmid-3384726 AB - The effects of radiation therapy on the ability of totally laryngectomized patients to produce voice and speech were examined using objective non-invasive methods. Moderate to severe losses were noted in patients producing voice with all types of alaryngeal modalities: tracheoesophageal, esophageal, and electrolaryngeal. Voice and speech losses were related to the impaired motility and vibratory capability of the esophageal wall and mucosa, to fibrosis of the submandibular region and to trismus. Tracheoesophageal and esophageal voice was recovered some weeks after completion of irradiation. No voice losses were observed in alaryngeal speakers who did not undergo voice restoration until after irradiation. All irradiated patients also showed various degrees of dysphagia during the treatment. JF - International Journal of Radiation Oncology, Biology, Physics AU - Izdebski, K AU - Fontanesi, J AU - Ross, J C AU - Hetzler, D AD - Veterans Administration Medical Center, Martinez, CA 94553. PY - 1988 SP - 1281 EP - 1286 VL - 14 IS - 6 SN - 0360-3016, 0360-3016 KW - Postoperative Care KW - Voice KW - Human KW - Radiotherapy KW - Laryngeal Neoplasms KW - Speech, Alaryngeal KW - Comparative Study KW - Laryngectomy KW - Radiotherapy Dosage KW - Particle Accelerators KW - Larynx, Artificial KW - Time Factors KW - Speech, Esophageal KW - Tracheoesophageal Fistula KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85282009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.atitle=The+effects+of+irradiation+on+alaryngeal+voice+of+totally+laryngectomized+patients.&rft.au=Izdebski%2C+K%3BFontanesi%2C+J%3BRoss%2C+J+C%3BHetzler%2C+D&rft.aulast=Izdebski&rft.aufirst=K&rft.date=1988-06-01&rft.volume=14&rft.issue=6&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.issn=03603016&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Radiology reports: assessment of a 5,000-word speech recognizer. AN - 85262081; pmid-3363152 AB - A prototype 5,000-word recognizer for the generation of radiologic reports by voice entry was evaluated. The system had a capacity sufficient enough to include all radiologic examinations and all desired words in one lexicon. The lack of such a capacity had been identified as a major limitation of a 1,000-word system previously evaluated. Overall reliability in word recognition was 98%. The device may be widely applicable for use in any radiology practice. JF - Radiology AU - Robbins, A H AU - Vincent, M E AU - Shaffer, K AU - Maietta, R AU - Srinivasan, M K AD - Department of Radiology, Boston Veterans Administration Medical Center, MA 02130. PY - 1988 SP - 853 EP - 855 VL - 167 IS - 3 SN - 0033-8419, 0033-8419 KW - Microcomputers KW - Speech KW - Software KW - Medical Records KW - Radiology Information Systems KW - Hospital Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85262081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Radiology+reports%3A+assessment+of+a+5%2C000-word+speech+recognizer.&rft.au=Robbins%2C+A+H%3BVincent%2C+M+E%3BShaffer%2C+K%3BMaietta%2C+R%3BSrinivasan%2C+M+K&rft.aulast=Robbins&rft.aufirst=A&rft.date=1988-06-01&rft.volume=167&rft.issue=3&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Carcinoma in a true diverticulum of the gallbladder. AN - 85213914; pmid-3132036 AB - Extensive search of the literature reveals the extreme rarity of true diverticulum of the gallbladder. Its frequency varies from 0.0008% of all resected gallbladders at the Mayo Clinic to 0.06% of a series of congenital anomalies of the gallbladder collected from the world literature. We are presenting a case of a true diverticulum of the gallbladder with sonographic demonstration and focal malignant alterations, neither one of which has been reported previously. The difference between true and false diverticula of the gallbladder is discussed. JF - The American Journal of Gastroenterology AU - Chin, N W AU - Chapman, I AD - Laboratory Service, Veterans Administration Medical Center, Brooklyn, New York. PY - 1988 SP - 667 EP - 669 VL - 83 IS - 6 SN - 0002-9270, 0002-9270 KW - Gallbladder Diseases KW - Human KW - Middle Age KW - Case Report KW - Gallbladder Neoplasms KW - Diverticulum KW - Ultrasonography KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Carcinoma+in+a+true+diverticulum+of+the+gallbladder.&rft.au=Chin%2C+N+W%3BChapman%2C+I&rft.aulast=Chin&rft.aufirst=N&rft.date=1988-06-01&rft.volume=83&rft.issue=6&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Associative encoding and retrieval in Alzheimer's and Huntington's disease. AN - 85212410; pmid-2969744 AB - The associative encoding and retrieval abilities of patients with dementia of the Alzheimer type (DAT) and patients with Huntington's disease (HD) were investigated using an encoding specificity paradigm. When compared to age- and education-matched intact control subjects, both patient groups were severely (and equally) impaired on overall memory for word lists. However, the HD and DAT patients showed differential improvement in recall performance with the introduction of associated cues during stimulus presentation and recall. Although the HD patients, like intact subjects, were able to benefit from semantic retrieval cues (strong and weak) which were present during input, the performance of the patients with DAT improved only with the introduction of strong cues at output, regardless of whether the cues were present or absent during initial presentation. These findings suggest that patients with DAT failed to encode the semantic relationship between the to-be-recalled and cue words and simply generated free associations to the cue words during retrieval. Similarities between the performances of the patients with DAT and alcoholic Korsakoff patients are noted and discussed with regard to the neuropathological basis of the disorders. JF - Brain and Cognition AU - Granholm, E AU - Butters, N AD - Psychology Service, San Diego Veterans Administration Medical Center, CA 92161. PY - 1988 SP - 335 EP - 347 VL - 7 IS - 3 SN - 0278-2626, 0278-2626 KW - Alcohol Amnestic Disorder KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Aging KW - Alzheimer Disease KW - Aged KW - Mental Recall KW - Receptors, Cholinergic KW - Semantics KW - Cues KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Huntington Disease KW - Learning KW - Association Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85212410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Associative+encoding+and+retrieval+in+Alzheimer%27s+and+Huntington%27s+disease.&rft.au=Granholm%2C+E%3BButters%2C+N&rft.aulast=Granholm&rft.aufirst=E&rft.date=1988-06-01&rft.volume=7&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Deficits in the implicit retention of new associations by alcoholic Korsakoff patients. AN - 85211401; pmid-3401385 AB - Word-stem completion in the presence or absence of a paired associate was assessed for a group of amnesic Korsakoff patients and a group of alcoholic controls. Since neither group demonstrated facilitation in the presence of cues (Experiment 1), an analysis of the influence of instructions to remember the paired associates on cued word-stem completion was performed with college students (Experiment 2). Finding a positive effect of instructions led to a replication of the task with amnesic patients and alcoholic controls. Unfortunately, instructions to remember the pairs did not produce the facilitatory effect for either group nor for an age matched nonalcoholic control group. (Experiment 3). It was concluded that neither amnesics, chronic alcoholics, nor elderly controls had the ability to modify their analysis of verbal material as a function of retrieval expectations. As a consequence, neither group demonstrated the effect of contextual priming of word completions reported by P. Graf and D. L. Schacter (1985, Journal of Experimental Psychology: Learning, Memory and Cognition, 11, 501-518). JF - Brain and Cognition AU - Cermak, L S AU - Bleich, R P AU - Blackford, S P AD - Memory Disorders Research Center, Boston Veterans Administration Medical Center, MA 02130. PY - 1988 SP - 312 EP - 323 VL - 7 IS - 3 SN - 0278-2626, 0278-2626 KW - Alcohol Amnestic Disorder KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Alcoholism KW - Adult KW - Aging KW - Cues KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Aged KW - Retention (Psychology) KW - Learning KW - Association Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Deficits+in+the+implicit+retention+of+new+associations+by+alcoholic+Korsakoff+patients.&rft.au=Cermak%2C+L+S%3BBleich%2C+R+P%3BBlackford%2C+S+P&rft.aulast=Cermak&rft.aufirst=L&rft.date=1988-06-01&rft.volume=7&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Metamemory in temporal lobe epilepsy: self-monitoring of memory functions. AN - 85211206; pmid-3401384 AB - Temporal lobe seizure patients and control subjects participated in an investigation of metamemory. The two-part study explored the individual's perception of memory abilities for both encoding and retrieval. Experiment I addressed self-monitoring of encoding through a study of prediction of memory span. Experiment II explored self-monitoring of retrieval through a study of "Feeling of Knowing." The results indicate that left and right temporal lobe seizure patients tend to overestimate their memory capacities, in comparison with normal controls, and that self-monitoring tends to be less accurate for material (verbal or nonverbal) mediated by side of lesion. The potential impact of inaccurate memory monitoring on the memory dysfunction observed in seizure patients is discussed. JF - Brain and Cognition AU - Prevey, M L AU - Delaney, R C AU - Mattson, R H AD - West Haven Veterans Administration Medical Center, CT 06516. PY - 1988 SP - 298 EP - 311 VL - 7 IS - 3 SN - 0278-2626, 0278-2626 KW - Human KW - Temporal Lobe KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Support, Non-U.S. Gov't KW - Middle Age KW - Laterality KW - Male KW - Female KW - Epilepsy, Temporal Lobe KW - Memory KW - Awareness KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Metamemory+in+temporal+lobe+epilepsy%3A+self-monitoring+of+memory+functions.&rft.au=Prevey%2C+M+L%3BDelaney%2C+R+C%3BMattson%2C+R+H&rft.aulast=Prevey&rft.aufirst=M&rft.date=1988-06-01&rft.volume=7&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Metabolic effects of acetaldehyde. AN - 78499900; 3181606 AB - Acetaldehyde, the toxic product of ethanol metabolism in the liver, covalently binds to a variety of proteins, thereby altering liver function and structure. Through its binding to tubulin, acetaldehyde decreases the polymerization of microtubules thereby impairing protein secretion and favouring their retention, with associated swelling of hepatocytes. Acetaldehyde adduct formation also impairs some enzyme activities. Either directly or through binding with GSH, acetaldehyde favours lipid peroxidation. Various mitochondrial functions are altered, particularly after chronic ethanol consumption which sensitizes the mitochondria to the toxic effects of acetaldehyde. In cultured myofibroblasts, acetaldehyde stimulates collagen production. The acetaldehyde-protein adducts stimulate the production of antibodies directed against the acetaldehyde epitope. This immune response may contribute to the aggravation or perpetuation of alcohol-induced liver damage. Some acetaldehyde effects, however, could conceivably be considered as beneficial, such as the stimulation of vascular prostacyclin release which may take part in the 'protective' effect of moderate ethanol consumption against some cardiovascular complications. JF - Biochemical Society transactions AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, New York. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 241 EP - 247 VL - 16 IS - 3 SN - 0300-5127, 0300-5127 KW - Iron KW - E1UOL152H7 KW - Glutathione KW - GAN16C9B8O KW - Acetaldehyde KW - GO1N1ZPR3B KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Cysteine -- metabolism KW - Cell Membrane -- drug effects KW - Glutathione -- metabolism KW - Humans KW - Intracellular Membranes -- drug effects KW - Mitochondria, Liver -- metabolism KW - Alcoholism -- metabolism KW - Mitochondria, Liver -- drug effects KW - Protein Binding KW - Lipid Peroxidation KW - Iron -- metabolism KW - Cell Membrane -- metabolism KW - Intracellular Membranes -- metabolism KW - Acetaldehyde -- blood KW - Acetaldehyde -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78499900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Society+transactions&rft.atitle=Metabolic+effects+of+acetaldehyde.&rft.au=Lieber%2C+C+S&rft.aulast=Lieber&rft.aufirst=C&rft.date=1988-06-01&rft.volume=16&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Biochemical+Society+transactions&rft.issn=03005127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-01 N1 - Date created - 1988-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The microsomal ethanol oxidizing system: its role in ethanol and xenobiotic metabolism. AN - 78496135; 3181604 AB - After chronic ethanol consumption, the activity of the microsomal ethanol-oxidizing system (MEOS) increases and contributes to ethanol tolerance, as most conclusively shown in alcohol-dehydrogenase-negative deermice. In man and animals, there is an associated rise in microsomal cytochrome P-450, including a specific form (P-450IIEI) with high affinity for ethanol and for the activation of some drugs (i.e. acetaminophen), carcinogens (i.e. N-nitrosodimethylamine) and hepatotoxic agents (i.e. CCl4), thereby contributing to the susceptibility of alcoholics to xenobiotics, including industrial solvents. In addition, a benzoflavone-inducible liver cytochrome P-450 isoenzyme distinct but catalytically similar to cytochrome P-450IIE1 was purified which may play a significant role in drinkers who also are heavy smokers. Cross-induction of other microsomal enzymes is associated with enhanced metabolism of various drugs, resulting in drug tolerance. Catabolism of retinol was also found to be accelerated, in part through activation of newly discovered vitamin A depletion and possibly toxicity. Thus, elucidation of the microsomal metabolism of ethanol explains a number of complications that develop in alcoholics. JF - Biochemical Society transactions AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, New York. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 232 EP - 239 VL - 16 IS - 3 SN - 0300-5127, 0300-5127 KW - Steroids KW - 0 KW - Vitamins KW - Xenobiotics KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Drug Interactions KW - Vitamins -- metabolism KW - Liver -- drug effects KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Steroids -- metabolism KW - Xenobiotics -- metabolism KW - Microsomes, Liver -- enzymology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78496135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Society+transactions&rft.atitle=The+microsomal+ethanol+oxidizing+system%3A+its+role+in+ethanol+and+xenobiotic+metabolism.&rft.au=Lieber%2C+C+S&rft.aulast=Lieber&rft.aufirst=C&rft.date=1988-06-01&rft.volume=16&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Biochemical+Society+transactions&rft.issn=03005127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-01 N1 - Date created - 1988-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of bromide, iodide, and fluoride with the pathways of chloride transport and diffusion in human neutrophils. AN - 78430303; 3047312 AB - Isolated human neutrophils possess three distinct pathways by which Cl- crosses the plasma membrane of steady state cells: anion exchange, active transport, and electrodiffusion. The purpose of the present work was to investigate the selectivity of each of these separate processes with respect to other external halide ions. (a) The bulk of total anion movements represents transport through an electrically silent anion-exchange mechanism that is insensitive to disulfonic stilbenes, but which can be competitively inhibited by alpha-cyano-4-hydroxycinnamate (CHC; Ki approximately 0.3 mM). The affinity of the external translocation site of the carrier for each of the different anions was determined (i) from substrate competition between Cl- and either Br-, F-, or I-, (ii) from trans stimulation of 36Cl- efflux as a function of the external concentrations of these anions, (iii) from changes in the apparent Ki for CHC depending on the nature of the replacement anion in the bathing medium, and (iv) from activation of 82Br- and 125I- influxes by their respective ions. Each was bound and transported at roughly similar rates (Vmax values all 1.0-1.4 meq/liter cell water.min); the order of decreasing affinities is Cl- greater than Br- greater than F- greater than I- (true Km values of 5, 9, 23, and 44 mM, respectively). These anions undergo 1:1 countertransport for internal Cl-. (b) There is a minor component of total Cl- influx that constitutes an active inward transport system for the intracellular accumulation of Cl- [( Cl-]i approximately 80 meq/liter cell water), fourfold higher than expected for passive distribution. This uptake is sensitive to intracellular ATP depletion by 2-deoxy-D-glucose and can be inhibited by furosemide, ethacrynic acid, and CHC, which also blocks anion exchange. This active Cl- uptake process binds and transports other members of the halide series in the sequence Cl- greater than Br- greater than I- greater than F- (Km values of 5, 8, 15, and 41 mM, respectively). (c) Electrodiffusive fluxes are small. CHC-resistant 82Br- and 125I- influxes behave as passive leak fluxes through low-conductance ion channels: they are nonsaturable and strongly voltage dependent. These anions permeate the putative Cl- channel in the sequence I- greater than Br- greater than Cl- with relative permeability ratios of 2.2:1.4:1, respectively, where PCl approximately 5 X 10(-9) cm/s. JF - The Journal of general physiology AU - Simchowitz, L AD - Department of Medicine, John Cochran Veterans Administration Medical Center, St. Louis, MO 63125. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 835 EP - 860 VL - 91 IS - 6 SN - 0022-1295, 0022-1295 KW - Anions KW - 0 KW - Bromides KW - Chlorides KW - Iodides KW - Fluorides KW - Q80VPU408O KW - Index Medicus KW - Drug Interactions KW - Humans KW - Ion Exchange KW - Biological Transport KW - Diffusion KW - Cell Membrane Permeability KW - Anions -- metabolism KW - Biological Transport, Active KW - Neutrophils -- metabolism KW - Fluorides -- metabolism KW - Iodides -- metabolism KW - Bromides -- metabolism KW - Chlorides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78430303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=Interactions+of+bromide%2C+iodide%2C+and+fluoride+with+the+pathways+of+chloride+transport+and+diffusion+in+human+neutrophils.&rft.au=Simchowitz%2C+L&rft.aulast=Simchowitz&rft.aufirst=L&rft.date=1988-06-01&rft.volume=91&rft.issue=6&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=00221295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-17 N1 - Date created - 1988-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Membr Biol. 1980;52(2):173-9 [6767850] Annu Rev Physiol. 1969;31:581-646 [4885777] J Physiol. 1949 Mar 1;108(1):37-77 [18128147] Ann N Y Acad Sci. 1969 Oct 31;147(19):829-41 [5261237] J Physiol. 1970 May;207(3):581-609 [5499737] J Physiol. 1972 Aug;224(3):583-610 [5071931] Blood. 1975 Jun;45(6):851-61 [164965] Biochem J. 1975 Apr;148(1):97-106 [1171687] J Gen Physiol. 1976 Feb;67(2):223-34 [1255128] Biochem J. 1976 May 15;156(2):193-207 [942406] Physiol Rev. 1977 Jan;57(1):109-56 [834775] J Membr Biol. 1977 Jan 28;30(4):319-50 [14260] J Gen Physiol. 1977 Mar;69(3):363-86 [15047] J Cell Biol. 1977 May;73(2):428-44 [558197] J Physiol. 1977 Jun;268(1):35-49 [874904] J Physiol. 1978 Feb;275:51-63 [633149] J Gen Physiol. 1979 Sep;74(3):351-74 [479826] J Physiol. 1979 Sep;294:521-39 [512956] Membr Biochem. 1979;2(2):255-81 [229385] J Gen Physiol. 1982 Jan;79(1):87-113 [7061989] J Gen Physiol. 1982 Mar;79(3):453-79 [6281359] Biochim Biophys Acta. 1982 Dec;694(4):353-74 [6760896] J Membr Biol. 1982;70(2):89-103 [6764785] Am J Physiol. 1984 Sep;247(3 Pt 1):C247-59 [6089577] J Gen Physiol. 1985 Mar;85(3):443-70 [2985737] J Clin Invest. 1985 Sep;76(3):1079-89 [2995444] J Physiol. 1985 Sep;366:267-80 [2997439] Biochim Biophys Acta. 1986 Sep 22;864(2):169-94 [3527268] J Gen Physiol. 1986 Aug;88(2):167-94 [3746250] J Gen Physiol. 1986 Aug;88(2):195-217 [3746251] J Clin Invest. 1980 Sep;66(3):493-503 [6249851] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carbohydrate-deficient transferrin, a marker for chronic alcohol consumption in different ethnic populations. AN - 78391694; 3044175 AB - Serum levels of carbohydrate-deficient transferrin (CDT) were determined in a racially mixed population of 107 alcoholics, 18 healthy, nonalcoholic control subjects, 62 abstinent alcoholics, and in 64 Caucasian patients with various nonalcoholic liver diseases. The upper limit of normal CDT levels was 80 mg/liter (2 SD above the mean). CDT values exceeding this level were found in more than 80% of Black, Puerto Rican, and Caucasian alcoholics who had consumed greater than or equal to 50 g of alcohol/day for 1 month or longer prior to testing. Puerto Rican alcoholics had higher CDT values than the Black and Caucasian ethnic groups; however, these differences were significant only when compared to the Black population. Of 64 patients with nonalcoholic liver diseases, one individual with chronic active hepatitis (CAH) with an alcohol consumption of 20 g/day, and 10 of 26 subjects with primary biliary cirrhoses (PBC), who claimed to consume either no or only occasional moderate amounts of alcohol, had CDT levels ranging from 81 to 144 mg/liter. Seven of these individuals were in advanced stages of PBC. Total transferrin levels were variable and not significantly different in all subject groups studied. CDT/total transferrin ratios were increased in most patients with abnormal amounts of CDT, and there was a significant correlation between these ratios and CDT levels in all study groups. Serum enzyme parameters as well as red blood cell mean corpuscular volumes did not correlate with CDT values.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Behrens, U J AU - Worner, T M AU - Braly, L F AU - Schaffner, F AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 427 EP - 432 VL - 12 IS - 3 SN - 0145-6008, 0145-6008 KW - Transferrin KW - 0 KW - carbohydrate-deficient transferrin KW - Transaminases KW - EC 2.6.1.- KW - Index Medicus KW - Transaminases -- blood KW - Liver Diseases -- blood KW - Puerto Rico -- ethnology KW - Humans KW - European Continental Ancestry Group KW - African Americans KW - Erythrocyte Indices KW - Liver Diseases, Alcoholic -- blood KW - Transferrin -- analogs & derivatives KW - Ethnic Groups KW - Alcoholism -- ethnology KW - Transferrin -- analysis KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78391694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Carbohydrate-deficient+transferrin%2C+a+marker+for+chronic+alcohol+consumption+in+different+ethnic+populations.&rft.au=Behrens%2C+U+J%3BWorner%2C+T+M%3BBraly%2C+L+F%3BSchaffner%2C+F%3BLieber%2C+C+S&rft.aulast=Behrens&rft.aufirst=U&rft.date=1988-06-01&rft.volume=12&rft.issue=3&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-12 N1 - Date created - 1988-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dose-response studies of intracerebroventricular infusion of aldosterone in sensitized and non-sensitized rats. AN - 78390904; 3411122 AB - We have shown previously that the intracerebroventricular (icvt) infusion of 5 ng/h aldosterone (ALD) in the sensitized rat (one kidney removed, 1% NaCl plus 0.15% KCl solution to drink) produced hypertension similar in amplitude and time of onset to a 100-fold dose administered subcutaneously (s.c.), while a 5-ng/h subcutaneous infusion had no effect on blood pressure (BP). Dose-response studies on the icvt infusion of ALD were carried out in sensitized and non-sensitized (intact, with tap water to drink) male Sprague-Dawley rats (SDR). In both studies, a control group received the diluent, artificial cerebrospinal fluid (CSF), icvt. In sensitized rats, the pressures became significantly (P less than 0.05) elevated at day 7 in those receiving 15 ng/h icvt, day 11 in those receiving 5 ng/h icvt and 500 ng/h s.c. and day 18 in those receiving 1.5 ng/h icvt. The indirect systolic BPs at day 20 of infusion were 119 +/- 0.8 (s.e.) mmHg for controls, 182 +/- 5 for 15 ng/h icvt, 140 +/- 2 mmHg for 5 ng/h icvt, 131 +/- 1 mmHg for 1.5 ng/h icvt, 125 +/- 1 mmHg for 0.5 ng/h, and 159 +/- 5 mmHg for 500 ng/h s.c. Recovery (removal of pumps and return to water to drink) for 18 days resulted in the return of normal pressures in all groups except the 15 ng/h, icvt group in which pressures remained slightly, but significantly elevated at 127 +/- 3 mmHg. In non-sensitized rats, the pressures became significantly elevated in animals receiving 45 ng/h icvt and 1 microgram/h s.c. by day 14.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of hypertension AU - Gomez Sanchez, E P AD - Research Service, J.A. Haley Veterans Administration Hospital, Tampa, Florida 33612. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 437 EP - 442 VL - 6 IS - 6 SN - 0263-6352, 0263-6352 KW - Sodium, Dietary KW - 0 KW - Aldosterone KW - 4964P6T9RB KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Sodium, Dietary -- administration & dosage KW - Cerebral Ventricles KW - Infusions, Parenteral KW - Male KW - Hypertension -- chemically induced KW - Aldosterone -- administration & dosage KW - Aldosterone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78390904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hypertension&rft.atitle=Dose-response+studies+of+intracerebroventricular+infusion+of+aldosterone+in+sensitized+and+non-sensitized+rats.&rft.au=Gomez+Sanchez%2C+E+P&rft.aulast=Gomez+Sanchez&rft.aufirst=E&rft.date=1988-06-01&rft.volume=6&rft.issue=6&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Journal+of+hypertension&rft.issn=02636352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-06 N1 - Date created - 1988-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contrast media-induced ventricular fibrillation. A comparison of Hypaque-76, Hexabrix, and Omnipaque. AN - 78355112; 3403207 AB - Contrast media occasionally produce ventricular fibrillation during coronary angiography. We compared the fibrillatory propensity of the conventional ionic contrast medium, Hypaque-76 (H76) to the low osmolar ionic dimer Hexabrix (HB) and to the nonionic agent Omnipaque (OM) in 20 open chest anesthetized dogs. Intracoronary injection of 6 mL of contrast medium produced spontaneous ventricular fibrillation in four of ten dogs with H76, compared with two of ten with HB, and zero of ten with OM (P = .07). The induction of two premature beats by programmed stimulation of the myocardium during injection of 4 mL of contrast medium produced ventricular fibrillation in ten of ten dogs with H76, compared with three of ten with HB, and zero of ten with OM (P less than .001). Both H76 and HB produced ventricular fibrillation in ten of ten dogs when three premature beats were induced, compared with two of ten dogs with OM (P less than .001). Four mL H76 produced a 109 +/- 18 msec increase in the QT interval, compared with an 82 +/- 17 msec increase with HB, and a 45 +/- 12 msec increase with OM. We conclude that both low osmolar HB and OM are less fibrillatory than the conventional ionic medium H76, and that the nonionic medium OM is less fibrillatory than the ionic dimer contrast medium HB. JF - Investigative radiology AU - Piao, Z E AU - Murdock, D K AU - Hwang, M H AU - Raymond, R M AU - Scanlon, P J AD - Department of Medicine, Hines Veterans Administration Hospital, IL 60141. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 466 EP - 470 VL - 23 IS - 6 SN - 0020-9996, 0020-9996 KW - Contrast Media KW - 0 KW - Drug Combinations KW - Diatrizoate KW - 117-96-4 KW - Diatrizoate Meglumine KW - 3X9MR4N98U KW - Iohexol KW - 4419T9MX03 KW - urovision KW - 8064-12-8 KW - Ioxaglic Acid KW - Z40X7EI2AF KW - Index Medicus KW - Animals KW - Angiography KW - Coronary Angiography KW - Drug Combinations -- toxicity KW - Dogs KW - Male KW - Female KW - Ioxaglic Acid -- toxicity KW - Ventricular Fibrillation -- chemically induced KW - Contrast Media -- toxicity KW - Iohexol -- toxicity KW - Diatrizoate -- toxicity KW - Diatrizoate Meglumine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78355112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+radiology&rft.atitle=Contrast+media-induced+ventricular+fibrillation.+A+comparison+of+Hypaque-76%2C+Hexabrix%2C+and+Omnipaque.&rft.au=Piao%2C+Z+E%3BMurdock%2C+D+K%3BHwang%2C+M+H%3BRaymond%2C+R+M%3BScanlon%2C+P+J&rft.aulast=Piao&rft.aufirst=Z&rft.date=1988-06-01&rft.volume=23&rft.issue=6&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Investigative+radiology&rft.issn=00209996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-22 N1 - Date created - 1988-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glycine microinjected in the rat dorsal vagal nucleus increases arterial pressure. AN - 78311027; 3391677 AB - Microinjections (25 nl) of glycine into the dorsal motor nucleus of the vagus in 21 rats elicited dose-dependent increases of arterial pressure and heart rate that were not seen with injections adjacent to the dorsal motor nucleus of the vagus. The responses to glycine were neurally mediated and could be blocked either by local pretreatment with strychnine or by combined vagotomy and ganglionic blockade. The data suggest that glycine receptors on, or in the region of, neurons of the dorsal motor nucleus of the vagus may have a role in the regulation of arterial pressure and heart rate. JF - Hypertension (Dallas, Tex. : 1979) AU - Talman, W T AD - Department of Neurology, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 664 EP - 667 VL - 11 IS - 6 Pt 2 SN - 0194-911X, 0194-911X KW - Propranolol KW - 9Y8NXQ24VQ KW - Strychnine KW - H9Y79VD43J KW - Chlorisondamine KW - JD3M24F66I KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Stimulation, Chemical KW - Rats, Inbred Strains KW - Rats KW - Chlorisondamine -- pharmacology KW - Animals KW - Vagotomy KW - Propranolol -- pharmacology KW - Strychnine -- pharmacology KW - Microinjections KW - Male KW - Glycine -- pharmacology KW - Vagus Nerve -- drug effects KW - Blood Pressure -- drug effects KW - Glycine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78311027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Glycine+microinjected+in+the+rat+dorsal+vagal+nucleus+increases+arterial+pressure.&rft.au=Talman%2C+W+T&rft.aulast=Talman&rft.aufirst=W&rft.date=1988-06-01&rft.volume=11&rft.issue=6+Pt+2&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-24 N1 - Date created - 1988-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Influence of infusion duration on the efficacy and toxicity of intravenous cyclosporine in bone marrow transplant patients. AN - 78292392; 3291288 JF - Transplantation proceedings AU - McGuire, T R AU - Tallman, M S AU - Yee, G C AU - Nemunaitis, J J AU - Higano, C S AU - McGuffin, R W AU - Singer, J W AD - Fred Hutchinson Cancer Research Center, Veterans Administration Medical Center, Seattle. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 501 EP - 504 VL - 20 IS - 3 Suppl 3 SN - 0041-1345, 0041-1345 KW - Cyclosporins KW - 0 KW - Index Medicus KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Humans KW - Retrospective Studies KW - Hypertension -- etiology KW - Graft vs Host Disease -- etiology KW - Kidney Diseases -- chemically induced KW - Cyclosporins -- toxicity KW - Cyclosporins -- administration & dosage KW - Bone Marrow Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78292392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Influence+of+infusion+duration+on+the+efficacy+and+toxicity+of+intravenous+cyclosporine+in+bone+marrow+transplant+patients.&rft.au=McGuire%2C+T+R%3BTallman%2C+M+S%3BYee%2C+G+C%3BNemunaitis%2C+J+J%3BHigano%2C+C+S%3BMcGuffin%2C+R+W%3BSinger%2C+J+W&rft.aulast=McGuire&rft.aufirst=T&rft.date=1988-06-01&rft.volume=20&rft.issue=3+Suppl+3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-01 N1 - Date created - 1988-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclosporine effects on isolated membranes, proximal tubule cells, and interstitium of the kidney. AN - 78291524; 3388513 AB - The pathogenesis of renal cell injury is a complex interplay among derangements in subcellular membrane function and mediators of injurious processes. Plasma and subcellular membrane injury and the resulting membrane dysfunction appear especially important. As detailed previously in this report, Cs, an extremely lipophilic compound, has the ability to bind to renal brush border membranes, interact with mitochondrial membranes resulting in multiple sites of dysfunction, and accumulate in high concentrations in renal proximal tubule cells. In spite of these interactions, Cs could not be shown to be directly toxic in vitro to proximal tubule cells. Thus, from these experiments, it is difficult to conclude that Cs-induced acute renal failure observed in vivo is due to a direct tubular toxic effect, even though Cs has the capability to interact with critical renal membranes at low concentrations. The majority of present evidence, therefore, does not suggest a toxic effect of Cs on renal epithelial cells. Instead, the acute effect of Cs to produce a decline in renal excretory function appears to be due to a fall in renal blood flow. On the other hand, the chronic effect of Cs to produce a decline in renal excretory function appears to be due to an effect of this agent to induce interstitial fibrosis. In this regard, recent findings summarized in this report demonstrate that Cs produces (over ten days) a higher than normal collagen content, as measured by hydroxyproline levels, in the kidney. In addition, this increase in collagen content with Cs treatment was associated with a significant increase in proliferation of cells in the renal interstitium, as determined by 3H-thymidine incorporation into DNA. This increase in DNA incorporation after Cs was not observed in other organs, including liver, spleen, or heart. Histologic assessment of these proliferating cells revealed them to be mononuclear. Cell surface markers also demonstrated an increase in LCA positive cells in the renal interstitium. These results, therefore, suggest a readily demonstrable effect of Cs on the renal interstitium. The relationship between Cs dosage and interstitial cell proliferation as well as the relationship between Cs-induced renal perfusion alterations and this interstitial proliferative process mandates further investigation. JF - Transplantation proceedings AU - Humes, H D AU - Jackson, N M AD - Veterans Administration Medical Center, Ann Arbor, MI 48105. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 748 EP - 758 VL - 20 IS - 3 Suppl 3 SN - 0041-1345, 0041-1345 KW - Cyclosporins KW - 0 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Rats KW - Animals KW - Oxygen Consumption -- drug effects KW - Kidney Cortex -- drug effects KW - Cell Survival -- drug effects KW - Collagen -- metabolism KW - Cell Division -- drug effects KW - Kidney Tubules, Proximal -- drug effects KW - Binding Sites KW - Microvilli -- drug effects KW - Mitochondria -- drug effects KW - Kidney -- drug effects KW - Cyclosporins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78291524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Cyclosporine+effects+on+isolated+membranes%2C+proximal+tubule+cells%2C+and+interstitium+of+the+kidney.&rft.au=Humes%2C+H+D%3BJackson%2C+N+M&rft.aulast=Humes&rft.aufirst=H&rft.date=1988-06-01&rft.volume=20&rft.issue=3+Suppl+3&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-01 N1 - Date created - 1988-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclosporine nephrotoxicity: a workshop to discuss mechanisms, diagnosis, and treatment. AN - 78290986; 3291323 JF - Transplantation proceedings AU - Humes, H D AU - Coffman, T AU - Halderman, H AU - Mihatsch, M AU - Henry, M AU - Porter, G A AD - Medical Service, Veterans Administration Medical Center, Ann Arbor, MI 48105. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 833 EP - 840 VL - 20 IS - 3 Suppl 3 SN - 0041-1345, 0041-1345 KW - Cyclosporins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Cyclosporins -- toxicity KW - Kidney Diseases -- therapy KW - Kidney Diseases -- diagnosis KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78290986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Cyclosporine+nephrotoxicity%3A+a+workshop+to+discuss+mechanisms%2C+diagnosis%2C+and+treatment.&rft.au=Humes%2C+H+D%3BCoffman%2C+T%3BHalderman%2C+H%3BMihatsch%2C+M%3BHenry%2C+M%3BPorter%2C+G+A&rft.aulast=Humes&rft.aufirst=H&rft.date=1988-06-01&rft.volume=20&rft.issue=3+Suppl+3&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-01 N1 - Date created - 1988-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased leukotriene B4 synthesis in immune injured rat glomeruli. AN - 78280548; 2838526 AB - We examined glomerular synthesis of the 5-lipoxygenase metabolite, LTB4, in normal and immune-injured rat glomeruli. Glomeruli isolated from normal rats and from rats with nephrotoxic serum nephritis (NSN), passive Heymann nephritis (PHN) and cationic bovine gamma globulin (CBGG)-induced glomerulonephritis were incubated with the calcium ionophore A23187 (3 microM). Lipids in the glomeruli and media were extracted with ethyl acetate, and were purified and fractionated by HPLC. Immunoreactive-LTB4 (i-LTB4) was determined by radioimmunoassay on HPLC fractions with a detection limit of 50 pg of i-LTB4. A large peak of i-LTB4 that comigrated with authentic LTB4 was found exclusively in glomeruli isolated from the CBGG-injected rats. Addition of the lipoxygenase inhibitor BW755C (50 micrograms/ml) to glomerular incubation resulted in greater than 90% inhibition of i-LTB4. Synthesis of i-LTB4 by glomeruli from normal, NSN and PHN rats was undetectable. Glomerular LTB4 synthesis by CBGG-injected rats was confirmed by radiometric HPLC and by gas chromatography mass-spectroscopy (GC-MS) analysis. In order to rule out synthesis of LTB4 by neutrophils entrapped in the glomeruli, a group of rats received 1,000 rad total body x irradiation, with shielding of the kidneys before induction of CBGG glomerulonephritis. Despite greater than 95% reduction in total leukocyte count, glomerular synthesis of LTB4 remained enhanced. Augmented glomerular synthesis of the proinflammatory lipid, LTB4, in the CBGG model of glomerular disease could have an important role in the development of glomerular injury and proteinuria. JF - The Journal of clinical investigation AU - Rahman, M A AU - Nakazawa, M AU - Emancipator, S N AU - Dunn, M J AD - Department of Medicine, Hines Veterans Administration Hospital, Illinois 60141. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 1945 EP - 1952 VL - 81 IS - 6 SN - 0021-9738, 0021-9738 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Pyrazoles KW - Leukotriene B4 KW - 1HGW4DR56D KW - 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine KW - 66000-40-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Rabbits KW - Radioimmunoassay KW - Chromatography, High Pressure Liquid KW - Rats, Inbred Strains KW - Rats KW - Neutrophils -- metabolism KW - Pyrazoles -- pharmacology KW - Gas Chromatography-Mass Spectrometry KW - Microscopy, Electron KW - Fluorescent Antibody Technique KW - Female KW - Male KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Nephritis -- metabolism KW - Kidney Glomerulus -- immunology KW - Nephritis -- immunology KW - Leukotriene B4 -- biosynthesis KW - Glomerulonephritis -- metabolism KW - Glomerulonephritis -- pathology KW - Kidney Glomerulus -- ultrastructure KW - Kidney Glomerulus -- metabolism KW - Nephritis -- pathology KW - Glomerulonephritis -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78280548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Increased+leukotriene+B4+synthesis+in+immune+injured+rat+glomeruli.&rft.au=Rahman%2C+M+A%3BNakazawa%2C+M%3BEmancipator%2C+S+N%3BDunn%2C+M+J&rft.aulast=Rahman&rft.aufirst=M&rft.date=1988-06-01&rft.volume=81&rft.issue=6&rft.spage=1945&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-03 N1 - Date created - 1988-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1967 Apr 25;242(8):1915-22 [6024780] Am J Physiol. 1986 May;250(5 Pt 2):F838-44 [3706536] J Ultrastruct Res. 1972 Mar;38(5):500-10 [4111070] Proc Natl Acad Sci U S A. 1979 May;76(5):2148-52 [377292] Biochem Pharmacol. 1979 Jun 15;28(12):1959-61 [110332] Proc Natl Acad Sci U S A. 1979 Sep;76(9):4275-9 [41240] Nature. 1980 May 8;285(5760):104-6 [7374755] J Pharm Pharmacol. 1980 Jul;32(7):517-8 [6105196] Nature. 1980 Jul 17;286(5770):264-5 [6250050] J Immunol. 1980 Oct;125(4):1789-91 [7410854] Nature. 1981 Feb 19;289(5799):646-50 [7464931] Br J Pharmacol. 1981 Mar;72(3):483-6 [6266567] J Pharm Pharmacol. 1981 Jul;33(7):466-8 [6115037] Proc Natl Acad Sci U S A. 1981 Jun;78(6):3887-91 [6267608] J Pharm Pharmacol. 1981 Sep;33(9):616-7 [6117650] Br J Pharmacol. 1981 Oct;74(2):429-33 [6274465] Proc Natl Acad Sci U S A. 1981 Dec;78(12):7692-6 [6950409] Clin Exp Immunol. 1982 Mar;47(3):541-7 [6282507] J Biol Chem. 1982 Sep 10;257(17):10294-9 [6809747] Biochem Biophys Res Commun. 1982 Aug;107(3):1006-12 [6291511] Biochem Biophys Res Commun. 1982 Oct 29;108(4):1531-7 [6295385] J Biol Chem. 1983 Apr 10;258(7):4325-30 [6403527] Can J Physiol Pharmacol. 1983 Apr;61(4):325-8 [6860996] J Clin Invest. 1983 Oct;72(4):1439-48 [6685136] Prostaglandins Leukot Med. 1984 Jan;13(1):21-5 [6324239] Prostaglandins. 1984 Feb;27(2):163-79 [6326199] Circ Res. 1984 May;54(5):492-9 [6722998] Lab Invest. 1984 Nov;51(5):515-23 [6238206] Lab Invest. 1984 Nov;51(5):524-33 [6238207] J Clin Invest. 1985 Jan;75(1):94-101 [4038407] J Immunol. 1985 May;134(5):3356-63 [2984287] J Appl Physiol (1985). 1986 Aug;61(2):584-91 [3017913] Kidney Int. 1986 Aug;30(2):246-54 [3531678] Prostaglandins. 1986 Jul;32(1):5-17 [3020620] J Exp Med. 1986 Dec 1;164(6):1973-87 [3537193] Kidney Int. 1986 Oct;30(4):524-31 [3465969] Kidney Int. 1987 Jun;31(6):1317-26 [2441106] Nephrol Dial Transplant. 1987;2(3):154-7 [2819788] AMA Arch Pathol. 1951 Jun;51(6):629-39 [14829136] J Pharmacol Exp Ther. 1985 Jun;233(3):672-8 [3859644] Lab Invest. 1985 Aug;53(2):122-31 [3894792] J Clin Invest. 1985 Oct;76(4):1355-9 [3932465] Adv Prostaglandin Thromboxane Leukot Res. 1985;15:61-5 [3004150] J Exp Med. 1968 Mar 1;127(3):555-72 [4866016] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - I-653 resists degradation in rats. AN - 78250968; 3377207 AB - The ability of rats pretreated with phenobarbital to metabolize a new volatile anesthetic, I-653, was compared with the metabolism of halothane, isoflurane, and methoxyflurane. Each anesthetic was administered for 2 hours at 1.6 MAC (inspired). Control rats were given phenobarbital but not exposed to an anesthetic. In rats pretreated with phenobarbital and exposed to I-653, fluoride ion concentrations in serum and excretion of fluoride ion and organic fluoride in the urine were almost indistinguishable from values measured in control rats. In contrast, rats pretreated with phenobarbital metabolized small but significant amounts of isoflurane. In rats pretreated with ethanol and exposed to I-653, the 24-hour excretion of urinary organic fluoride was nearly ten times greater than that observed in control rats. Marked increases in organic fluoride (as high as 1000 times control values) and/or fluoride ion were found in serum and/or urine after anesthesia of phenobarbital-pretreated rats with halothane or methoxyflurane. The relative stability of I-653 indicates that it may possess minimal toxic properties. JF - Anesthesia and analgesia AU - Koblin, D D AU - Eger, E I AU - Johnson, B H AU - Konopka, K AU - Waskell, L AD - Department of Anesthesia, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 534 EP - 538 VL - 67 IS - 6 SN - 0003-2999, 0003-2999 KW - Anesthetics KW - 0 KW - Methoxyflurane KW - 30905R8O7B KW - Ethanol KW - 3K9958V90M KW - desflurane KW - CRS35BZ94Q KW - Isoflurane KW - CYS9AKD70P KW - Fluorides KW - Q80VPU408O KW - Halothane KW - UQT9G45D1P KW - Phenobarbital KW - YQE403BP4D KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Phenobarbital -- pharmacology KW - Halothane -- metabolism KW - Drug Interactions KW - Ethanol -- pharmacology KW - Biotransformation KW - Fluorides -- blood KW - Methoxyflurane -- metabolism KW - Fluorides -- urine KW - Isoflurane -- metabolism KW - Anesthetics -- metabolism KW - Isoflurane -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78250968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=I-653+resists+degradation+in+rats.&rft.au=Koblin%2C+D+D%3BEger%2C+E+I%3BJohnson%2C+B+H%3BKonopka%2C+K%3BWaskell%2C+L&rft.aulast=Koblin&rft.aufirst=D&rft.date=1988-06-01&rft.volume=67&rft.issue=6&rft.spage=534&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-30 N1 - Date created - 1988-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - "Bicycle kickstand" phenomenon: prolonged erections associated with antipsychotic agents. AN - 78247211; 2897718 AB - The purpose of this paper is to draw attention to the ability of some antipsychotic agents to produce sustained erection short of priapism. They appear to have this effect consistently over time in some individuals. The effect is rapidly reversible on discontinuation of the drug, and appears to be dose-dependent. In one of our patients, the "active metabolite" of that same drug could not duplicate the effect. Prevalence and mechanism require clarification. If even a small proportion of patients with the sustained erection phenomenon are found to progress to priapism, this would have profound ramifications. If this phenomenon could be confidently predicted or safely and readily implemented, the benefits for some patients with impotence or premature ejaculation might be considerable. Given all the potential adverse side effects of antipsychotics, it should be appreciated that the potential direct effects on male sexual function are not always adverse. JF - Southern medical journal AU - Gold, D D AU - Justino, J D AD - Veterans Administration Medical Center, Bay Pines, Fla. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 792 EP - 794 VL - 81 IS - 6 SN - 0038-4348, 0038-4348 KW - Antipsychotic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Penile Erection -- drug effects KW - Male KW - Priapism -- chemically induced KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78247211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=%22Bicycle+kickstand%22+phenomenon%3A+prolonged+erections+associated+with+antipsychotic+agents.&rft.au=Gold%2C+D+D%3BJustino%2C+J+D&rft.aulast=Gold&rft.aufirst=D&rft.date=1988-06-01&rft.volume=81&rft.issue=6&rft.spage=792&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-08 N1 - Date created - 1988-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Do protein and phosphorus cause calcium loss? AN - 78237505; 3286844 AB - The widespread opinion that both protein and phosphorus cause calcium loss is examined. Controlled human studies show that commonly used complex dietary proteins, which have a high phosphorus content, do not cause calcium loss in adult humans. Similarly, a phosphorus intake of up to 2000 mg/d does not have adverse effects on calcium metabolism; however, the type of phosphate contained in carbonated beverages may not behave in the same manner. In contrast, a diet low in protein and phosphorus may have adverse effects on calcium balance in the elderly. Studies with adults suggest that high protein foods do not cause calcium loss. JF - The Journal of nutrition AU - Spencer, H AU - Kramer, L AU - Osis, D AD - Metabolic Research, Veterans Administration Hospital, Hines, IL 60141. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 657 EP - 660 VL - 118 IS - 6 SN - 0022-3166, 0022-3166 KW - Dietary Proteins KW - 0 KW - Phosphorus KW - 27YLU75U4W KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Meat -- adverse effects KW - Humans KW - Bone and Bones -- metabolism KW - Carbonated Beverages -- adverse effects KW - Calcium -- metabolism KW - Dietary Proteins -- metabolism KW - Phosphorus -- metabolism KW - Dietary Proteins -- adverse effects KW - Phosphorus -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78237505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Do+protein+and+phosphorus+cause+calcium+loss%3F&rft.au=Spencer%2C+H%3BKramer%2C+L%3BOsis%2C+D&rft.aulast=Spencer&rft.aufirst=H&rft.date=1988-06-01&rft.volume=118&rft.issue=6&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-11 N1 - Date created - 1988-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Response to exercise after withdrawal from chronic alcoholism. AN - 78230730; 2836135 AB - To test for early evidence of alcoholic cardiomyopathy and to assess changes in exercise response after abstinence, 12 asymptomatic alcoholic men (group 1) underwent maximal upright bicycle exercise radionuclide ventriculography two to six days after alcohol withdrawal. Six of these patients (group 1A) had similar testing two to four weeks later. Six control subjects (group 2) had repeated exercise tests without isotope study. Group 1 left ventricular ejection fraction response (LVEF) was normal. LVEF at similar workloads did not differ in group 1A (p = NS). However, unlike group 2 results, the linear regression line relating double product to exercise stage in group 1A was higher at first exercise (p less than 0.05), probably due to the effects of alcohol withdrawal. We conclude that radionuclide left ventriculographic findings in these patients do not support the concept of a preclinical alcoholic cardiomyopathy made apparent by exercise, and exercise very early after alcohol withdrawal is associated with an increased myocardial oxygen demand at any given workload. JF - Chest AU - Moskowitz, R M AU - Parent, M G AU - Marshall, R C AU - Barnett, C A AU - Errichetti, A J AD - Cardiology Section, Martinez Veterans Administration Medical Center, CA 94553. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 1190 EP - 1195 VL - 93 IS - 6 SN - 0012-3692, 0012-3692 KW - Sodium Pertechnetate Tc 99m KW - A0730CX801 KW - Abridged Index Medicus KW - Index Medicus KW - Blood Pressure KW - Heart Ventricles -- diagnostic imaging KW - Humans KW - Echocardiography KW - Radionuclide Imaging KW - Exercise Test KW - Heart Rate KW - Electrocardiography KW - Adult KW - Middle Aged KW - Temperance KW - Male KW - Stroke Volume KW - Cardiomyopathy, Alcoholic -- diagnosis KW - Cardiomyopathy, Alcoholic -- physiopathology KW - Physical Exertion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78230730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Response+to+exercise+after+withdrawal+from+chronic+alcoholism.&rft.au=Moskowitz%2C+R+M%3BParent%2C+M+G%3BMarshall%2C+R+C%3BBarnett%2C+C+A%3BErrichetti%2C+A+J&rft.aulast=Moskowitz&rft.aufirst=R&rft.date=1988-06-01&rft.volume=93&rft.issue=6&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-07 N1 - Date created - 1988-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pharmacotherapy for Aphasia AN - 58191484; 8809369 AB - Selected features of aphasia may reflect disruption of specific neurotransmitter systems. Pharmacotherapy focused on these aphasic symptoms may improve lang performance following stroke. An attempt was made to restore speech fluency in a patient with long-standing transcortical motor aphasia by treating his symptoms of hesitancy & impaired initiation of speech with bromocriptine. During therapy his lang performance improved substantially, due to reduced latency of response, decreased paraphasias, & increased naming ability. After cessation of drug therapy his lang returned to baseline. 2 Tables, 15 References. HA JF - Neurology AU - Albert, Martin L AU - Bachman, David L AU - Morgan, Alisa AU - Helm-Estabrooks, Nancy AD - Boston Veterans Administration Medical Center, 150 S Huntington Ave MA 02130 Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 877 EP - 879 VL - 38 IS - 6 SN - 0028-3878, 0028-3878 KW - aphasic, pharmacotherapeutic treatment KW - transcortical motor aphasia, bromocriptine treatment KW - case study KW - Drug Effects (dr2) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58191484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Pharmacotherapy+for+Aphasia&rft.au=Albert%2C+Martin+L%3BBachman%2C+David+L%3BMorgan%2C+Alisa%3BHelm-Estabrooks%2C+Nancy&rft.aulast=Albert&rft.aufirst=Martin&rft.date=1988-06-01&rft.volume=38&rft.issue=6&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Drug Effects (dr2) ER - TY - JOUR T1 - Error Patterns during Repetition of Consonant-Vowel-Consonant Syllables by Apraxic Speakers AN - 58186292; 8809451 AB - Nine speakers with verbal apraxia repeated 12 cons-vowel-cons target syllables four times each. The apraxic speakers produced 71 of the 108 pairs of productions (66%) in the same manner for first & last trials. Significantly more errors were produced in voiced than in voiceless contexts. Differences in the number of misarticulations of target words containing the vowels /i, (script a), u/ were not significant. Clinical implications are discussed & additional investigation is suggested. 3 Tables, 13 References. HA JF - Journal of Communication Disorders AU - Skenes, Linda Lilley AU - Trullinger, Richard W AD - Audiology & Speech Pathology Veterans Administration Medical Center, Augusta GA 30910 Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 263 EP - 269 VL - 21 IS - 3 SN - 0021-9924, 0021-9924 KW - apraxic pronunciation repetition, error patterns KW - syllable misarticulation KW - Syllable (sy1) KW - Error Analysis (er1) KW - Pronunciation Accuracy (pr9) KW - Language Pathology (la4) KW - Articulation Disorders (ar4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58186292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Error+Patterns+during+Repetition+of+Consonant-Vowel-Consonant+Syllables+by+Apraxic+Speakers&rft.au=Skenes%2C+Linda+Lilley%3BTrullinger%2C+Richard+W&rft.aulast=Skenes&rft.aufirst=Linda&rft.date=1988-06-01&rft.volume=21&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Error Analysis (er1); Syllable (sy1); Pronunciation Accuracy (pr9); Articulation Disorders (ar4) ER - TY - JOUR T1 - Changing the Vocal Characteristics of a Postoperative Transsexual Patient: A Longitudinal Study AN - 58183123; 8809429 AB - The vocal characteristics of a 63-year-old individual who underwent M-to-F sex reassignment surgery were evaluated. Treatment was designed to alter inappropriate M voice characteristics. Speech goals were to (1) encourage use of successively higher pitch levels, & (2) modify tongue carriage to change resonance. After 11 months of therapy, average fundamental f for /i, a, u/ vowels changed from 110 to 250 hertz (Hz). Also, second formant f values changed remarkably for each of these vowels, with the greatest f change being 291 Hz for /i/. These acoustic differences could account for the perception of femininity in her posttreatment voice. Maintenance of these acoustic features was found five years posttreatment. 1 Table, 2 Figures, 18 References. HA JF - Journal of Communication Disorders AU - Mount, Kay H AU - Salmon, Shirley J AD - Audiology & Speech Pathology Service Veterans Administration Medical Center, 4801 Linwood Blvd Kansas City MO 64128 Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 229 EP - 238 VL - 21 IS - 3 SN - 0021-9924, 0021-9924 KW - vocal characteristics adjustment, postoperative transsexual patient KW - longitudinal study KW - fundamental/formant frequency changes KW - Sexual Differences (se15) KW - Speech Therapy (sp13) KW - Formant Frequency (fo4) KW - Language Pathology (la4) KW - Fundamental Frequency (fu2) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58183123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Changing+the+Vocal+Characteristics+of+a+Postoperative+Transsexual+Patient%3A+A+Longitudinal+Study&rft.au=Mount%2C+Kay+H%3BSalmon%2C+Shirley+J&rft.aulast=Mount&rft.aufirst=Kay&rft.date=1988-06-01&rft.volume=21&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Fundamental Frequency (fu2); Sexual Differences (se15); Formant Frequency (fo4); Speech Therapy (sp13) ER - TY - JOUR T1 - An electron microscopic study of MPTP-induced inclusion bodies in an old monkey. AN - 78308668; 3260534 AB - Eosinophilic inclusion bodies have recently been found in the nerve cells of the substantia nigra in aged primates with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. This report describes the ultrastructure of the inclusion-bearing nerve cells in the substantia nigra from one of these animals. By electron microscopy the inclusions were less well demarcated and less conspicuous than those seen in hematoxylin-eosin stained paraffin sections. The bodies corresponded to portions of the nerve cell that were devoid of Nissl substance, but contained an increased number of randomly oriented, thick filamentous or tubular structures with some resemblance to neurotubules. The inclusion bodies were compared to Pick bodies: argentophilic inclusions in Pick's disease, a rare form of dementia, and to Lewy bodies: the inclusions characteristically present in Parkinson's disease. The MPTP-induced inclusions differed from both Pick bodies and Lewy bodies, but could represent immature Lewy bodies, similar to Lewy bodies in the cerebral cortex. The mechanism of formation of these structures, their relationship to Parkinson's disease and the reason why they appear to require the substrate of an aged nervous system, remain to be determined. JF - Brain research AU - Forno, L S AU - Langston, J W AU - DeLanney, L E AU - Irwin, I AD - Veterans Administration Medical Center, Palo Alto, CA 94304. Y1 - 1988/05/10/ PY - 1988 DA - 1988 May 10 SP - 150 EP - 157 VL - 448 IS - 1 SN - 0006-8993, 0006-8993 KW - Pyridines KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Index Medicus KW - Saimiri KW - Animals KW - Microscopy, Electron KW - Substantia Nigra -- pathology KW - Substantia Nigra -- ultrastructure KW - Pyridines -- toxicity KW - Substantia Nigra -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78308668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=An+electron+microscopic+study+of+MPTP-induced+inclusion+bodies+in+an+old+monkey.&rft.au=Forno%2C+L+S%3BLangston%2C+J+W%3BDeLanney%2C+L+E%3BIrwin%2C+I&rft.aulast=Forno&rft.aufirst=L&rft.date=1988-05-10&rft.volume=448&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-25 N1 - Date created - 1988-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Semantic Knowledge in Aphasia AN - 85330317; llba-8809423 AB - During the 1970s, interest arose as to whether an aphasic's inability to name an object might be due to an inadequate conceptual knowledge about that object. Some of the most compelling evidence for a disrupted semantic knowledge in aphasia is found in the aphasics' treatment of function relations. When considering a pair or a group of words or pictures, the aphasic often fails to notice a shared function or action such as cutting or hopping. Discussion here includes whether the results from these studies can be interpreted as evidence that fluent aphasics have a semantic organization that differs from nonfluent aphasics & normals, or whether other factors could be contributing to the aphasics' poor performance on function items. 7 References. Modified AA JF - Aphasiology AU - McCleary, Carol AD - Psychology Research Service 116B Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 343 EP - 345 VL - 2 IS - 3-4 SN - 0268-7038, 0268-7038 KW - aphasia, semantic knowledge KW - object naming, shared function KW - *Semantics (se9) KW - *Aphasia (ap1) KW - *Cognitive Processes (co1b) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85330317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Semantic+Knowledge+in+Aphasia&rft.au=McCleary%2C+Carol&rft.aulast=McCleary&rft.aufirst=Carol&rft.date=1988-05-01&rft.volume=2&rft.issue=3-4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (ap1); *Cognitive Processes (co1b); *Semantics (se9) ER - TY - JOUR T1 - Prediction of variceal hemorrhage: a prospective study. AN - 85215592; pmid-3259071 AB - Prophylactic therapy to prevent the first variceal hemorrhage ceased being recommended for any cirrhotic because risks outweighed benefits. In this study, we identified cirrhotics that have never bled who are most prone to hemorrhage from varices. We developed a numerical grading system which combined size with other endoscopic characteristics, so varices would get an aggregate grade of 1 to 10. Varices were classified as either high grade (scored greater than or equal to 8) or low grade (scored less than or equal to 7). The grading system had a predictive value for bleeding when studied prospectively for a mean duration of 26 months in 52 patients subjected to placebo (15 patients) or various treatments (37 patients) in a randomized trial. High grade varices had a significantly higher association with bleeding than did low grade varices; 73% versus 7% (p less than 0.001) analyzing all 52 patients (of which 21% bled), and 83% versus 11% (p less than 0.05) analyzing the 15 placebo-treated patients (of which 40% bled). An esophagram positive for varices proved to be a sensitive screen for high grade varices, picking up 91% of them. However, it was a poor predictor of bleeding (one-third bled), since only 45% of radiologically evident varices were high grade. Since almost all cirrhotics with high grade varices can be expected to bleed within 2 yr, this group should be the focus of controlled trials to determine whether low risk prophylactic therapies reduce the incidence of first variceal hemorrhage. JF - The American Journal of Gastroenterology AU - Snady, H AU - Feinman, L AD - Section of Gastroenterology, Liver Disease, and Nutrition, Veterans Administration Medical Center, Bronx, New York. PY - 1988 SP - 519 EP - 525 VL - 83 IS - 5 SN - 0002-9270, 0002-9270 KW - Prospective Studies KW - Support, U.S. Gov't, P.H.S. KW - Propranolol KW - Combined Modality Therapy KW - Human KW - Esophageal and Gastric Varices KW - Gastrointestinal Hemorrhage KW - Prognosis KW - Support, U.S. Gov't, Non-P.H.S. KW - Sclerosing Solutions KW - Esophagoscopy KW - Liver Cirrhosis, Alcoholic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85215592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Prediction+of+variceal+hemorrhage%3A+a+prospective+study.&rft.au=Snady%2C+H%3BFeinman%2C+L&rft.aulast=Snady&rft.aufirst=H&rft.date=1988-05-01&rft.volume=83&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Oral chenodeoxycholic acid increases small intestinal permeability to lactulose in humans. AN - 85213821; pmid-3129932 AB - In animals, chenodeoxyholic acid (chenodiol) causes significant small intestinal mucosal injury which is paralleled by increased intestinal permeability. The objective of this study was to determine whether chenodiol increases small intestinal mucosal permeability in humans. This was assessed in a before-after trial by collecting urine from nine fasted healthy male volunteers for 3 h after oral intake of an isotonic solution containing 1 g mannitol, 5 g L-rhamnose and 10 g lactulose, all nondigestible sugars. After at least 72 h, this was repeated 1 h after taking 750 mg of chenodiol orally. The amount of each sugar excreted in the urine was quantified by high performance liquid chromatography. Chenodiol doubled the percent urinary excretion of lactulose from 0.21 +/- 0.12 (SD) to 0.42% +/- 0.25 (p less than 0.02) and the ratio of lactulose to mannitol or to rhamnose [0.012 +/- 0.005 to 0.027 +/- 0.013 (p less than 0.01) and 0.045 +/- 0.022 to 0.087 +/- 0.039 (p less than 0.05), respectively]. Oral administration of 750 mg chenodiol is associated with increased small intestinal permeability to lactulose in humans, supporting the possibility that this drug may also cause acute small intestinal mucosal injury. JF - The American Journal of Gastroenterology AU - Erickson, R A AU - Epsten, R M AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, California. PY - 1988 SP - 541 EP - 544 VL - 83 IS - 5 SN - 0002-9270, 0002-9270 KW - Administration, Oral KW - Permeability KW - Mannitol KW - Chenodeoxycholic Acid KW - Human KW - Adult KW - Intestine, Small KW - Chromatography, High Pressure Liquid KW - Male KW - Rhamnose KW - Disaccharides KW - Lactulose UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Oral+chenodeoxycholic+acid+increases+small+intestinal+permeability+to+lactulose+in+humans.&rft.au=Erickson%2C+R+A%3BEpsten%2C+R+M&rft.aulast=Erickson&rft.aufirst=R&rft.date=1988-05-01&rft.volume=83&rft.issue=5&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Squamous mucosa overlying columnar epithelium in Barrett's esophagus in the absence of anti-reflux surgery. AN - 85213620; pmid-3364411 AB - Seven of 45 patients with Barrett's esophagus prospectively followed with yearly endoscopy had histological evidence of squamous mucosa overlying Barrett's epithelium. This histological finding has previously been identified as a rare sequela of anti-reflux surgery. All seven patients had specialized columnar epithelium. No evidence of the overlying mucosa was recognized at endoscopy. Only one patient had previous anti-reflux surgery. During the observation interval, three patients had a decrease, and four had no change in the length of Barrett's epithelium. Squamous mucosa overlying columnar epithelium in Barrett's esophagus is not infrequent, and prior anti-reflux surgery is not a necessary precondition. JF - The American Journal of Gastroenterology AU - Sampliner, R E AU - Steinbronn, K AU - Garewal, H S AU - Riddell, R H AD - Department of Medicine, Veterans Administration Medical Center, Tucson, Arizona. PY - 1988 SP - 510 EP - 512 VL - 83 IS - 5 SN - 0002-9270, 0002-9270 KW - Esophagus KW - Human KW - Mucous Membrane KW - Aged KW - Middle Age KW - Barrett Esophagus KW - Epithelium KW - Esophageal Diseases KW - Gastroesophageal Reflux UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Squamous+mucosa+overlying+columnar+epithelium+in+Barrett%27s+esophagus+in+the+absence+of+anti-reflux+surgery.&rft.au=Sampliner%2C+R+E%3BSteinbronn%2C+K%3BGarewal%2C+H+S%3BRiddell%2C+R+H&rft.aulast=Sampliner&rft.aufirst=R&rft.date=1988-05-01&rft.volume=83&rft.issue=5&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Pharmacological treatment of tobacco dependence. AN - 78467623; 3051049 AB - Pharmacologically based approaches for the treatment of tobacco dependence are reviewed. The rational basis for pharmacologic treatment approaches is that tobacco dependence is partially, and critically, mediated by the actions of tobacco-delivered nicotine to the central nervous system. These actions include direct reinforcing properties of nicotine itself, tolerance and physiologic dependence, possible beneficial effects of nicotine in the alleviation of anxiety and control of weight, and neurohormonal regulation which can become important to the maintenance of emotional well-being and performance at work. Insofar as tobacco abstinence leads to negative consequences, via these biobehavioral mechanisms, pharmacologic intervention should be able to assist in initial tobacco detoxification and help tobacco abstinent persons to avoid subsequent relapse. The purpose of this review is to survey some of the efforts to develop such interventions, as well as to elucidate some of the issues relevant to such development. Four distinct approaches are discussed: (1) Nicotine replacement, in which physiologic dependence is transferred to a safer and more therapeutically manageable nicotine delivering formulation; this category includes nicotine polacrilex gum; (2) Blockade therapy, in which a drug is taken that blocks the reinforcing properties of nicotine should relapse occur; (3) Nonspecific pharmacotherapy, in which the biobehaviorally mediated correlates of tobacco abstinence are treated on a symptomatic basis; (4) Deterrent therapy, in which a drug is taken prior to smoking such that any tobacco use would produce reliable aversive effects. JF - Pharmacology, biochemistry, and behavior AU - Jarvik, M E AU - Henningfield, J E AD - Psychopharmacology Unit, Veterans Administration Medical Center, Brentwood, Los Angeles, CA 90073. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 279 EP - 294 VL - 30 IS - 1 SN - 0091-3057, 0091-3057 KW - Chewing Gum KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Nicotine -- therapeutic use KW - Nicotine -- antagonists & inhibitors KW - Affect -- drug effects KW - Psychomotor Performance -- drug effects KW - Humans KW - Body Weight -- drug effects KW - Substance Withdrawal Syndrome -- drug therapy KW - Smoking -- drug therapy KW - Tobacco Use Disorder -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78467623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Pharmacological+treatment+of+tobacco+dependence.&rft.au=Jarvik%2C+M+E%3BHenningfield%2C+J+E&rft.aulast=Jarvik&rft.aufirst=M&rft.date=1988-05-01&rft.volume=30&rft.issue=1&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-31 N1 - Date created - 1988-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of ethanol and calcium on lipid order of membranes from mice selected for genetic differences in ethanol intoxication. AN - 78420757; 3415769 AB - Fluorescent probes were used to compare the physical properties of membranes from mice selected for sensitivity (LS) and insensitivity (SS) to the hypnotic action of ethanol. Brain synaptic plasma membranes (SPM) from LS mice were more sensitive to the disordering action of ethanol than those from LS mice when probes were located near the membrane surface. However, the membrane core of membranes from the two lines was equally sensitive to ethanol. The genetic differences in ethanol sensitivity of the membrane surface were eliminated when fluorescence measurements were carried out in the presence of 2-3 mM CaCl2. Consistent with behavioral data, differential genetic sensitivity to the disordering action was not obtained with longer chain alcohols. The genetic difference in ethanol sensitivity was not detected with erythrocyte membranes or lipids extracted from SPM. These results indicate that there is a structural difference in the surface of brain membranes of LS and SS mice than may influence their sensitivity to ethanol. JF - Alcohol (Fayetteville, N.Y.) AU - Harris, R A AU - Zaccaro, L M AU - McQuilkin, S AU - McClard, A AD - Denver Veterans Administration Medical Center, Alcohol Research Center, CO. PY - 1988 SP - 251 EP - 257 VL - 5 IS - 3 SN - 0741-8329, 0741-8329 KW - Alcohols KW - 0 KW - Membrane Lipids KW - Ethanol KW - 3K9958V90M KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Spectrometry, Fluorescence KW - Dose-Response Relationship, Drug KW - Mice KW - Alcohols -- pharmacology KW - Membrane Lipids -- genetics KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Membrane Lipids -- metabolism KW - Calcium -- pharmacology KW - Brain -- metabolism KW - Sleep Stages -- drug effects KW - Alcoholic Intoxication -- genetics KW - Synaptic Membranes -- metabolism KW - Synaptic Membranes -- drug effects KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78420757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Effects+of+ethanol+and+calcium+on+lipid+order+of+membranes+from+mice+selected+for+genetic+differences+in+ethanol+intoxication.&rft.au=Harris%2C+R+A%3BZaccaro%2C+L+M%3BMcQuilkin%2C+S%3BMcClard%2C+A&rft.aulast=Harris&rft.aufirst=R&rft.date=1988-05-01&rft.volume=5&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-20 N1 - Date created - 1988-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment. AN - 78311877; 3390980 AB - A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517-744 ng/ml). In the course of recovery from o,p' DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its biosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment. JF - Clinical nuclear medicine AU - Sparagana, M AU - Ackerman, L AD - Medical Service, Veterans Administration Hospital, Hines, Illinois. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 348 EP - 351 VL - 13 IS - 5 SN - 0363-9762, 0363-9762 KW - Iodine Radioisotopes KW - 0 KW - 19-Iodocholesterol KW - 30461-91-7 KW - 6-iodomethylcholesterol KW - 68232-36-0 KW - Mitotane KW - 78E4J5IB5J KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Humans KW - Adult KW - Recurrence KW - Male KW - Radionuclide Imaging KW - Mitotane -- therapeutic use KW - 19-Iodocholesterol -- analogs & derivatives KW - Cholesterol -- analogs & derivatives KW - Adrenal Glands -- physiopathology KW - Adrenal Glands -- drug effects KW - ACTH Syndrome, Ectopic -- drug therapy KW - Paraneoplastic Endocrine Syndromes -- drug therapy KW - Mitotane -- adverse effects KW - Adrenal Glands -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78311877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=Positive+iodine-131+6+beta-iodomethyl-19-norcholesterol+%28NP-59%29+adrenal+images+can+precede+return+of+adrenocortical+function+after+o%2Cp%27+DDD+treatment.&rft.au=Sparagana%2C+M%3BAckerman%2C+L&rft.aulast=Sparagana&rft.aufirst=M&rft.date=1988-05-01&rft.volume=13&rft.issue=5&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-17 N1 - Date created - 1988-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 'Revised' mass spectral identification of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites. AN - 78262705; 3382804 AB - The electron ionization mass spectra of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites obtained from microsomal incubations and chemical syntheses were studied. The identities of the metabolites were established by chemical ionization, high resolution, and metastable measurements. The compounds studied showed multiple modes of cleavage, skeletal rearrangements and hydrogen back-transfer. JF - Biomedical & environmental mass spectrometry AU - Mattammal, M B AU - Lakshmi, V M AU - Zenser, T V AU - Davis, B B AU - White, E AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St Louis, Missouri. Y1 - 1988/05/01/ PY - 1988 DA - 1988 May 01 SP - 495 EP - 499 VL - 15 IS - 9 SN - 0887-6134, 0887-6134 KW - Carcinogens KW - 0 KW - Thiazoles KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - Index Medicus KW - Oxidation-Reduction KW - Mass Spectrometry KW - Animals KW - Sheep KW - Microsomes -- metabolism KW - In Vitro Techniques KW - Gas Chromatography-Mass Spectrometry KW - Male KW - Chromatography, High Pressure Liquid KW - Carcinogens -- metabolism KW - FANFT -- analogs & derivatives KW - FANFT -- metabolism KW - Carcinogens -- analysis KW - Thiazoles -- analysis KW - FANFT -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78262705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+%26+environmental+mass+spectrometry&rft.atitle=%27Revised%27+mass+spectral+identification+of+2-amino-4-%285-nitro-2-furyl%29thiazole+metabolites.&rft.au=Mattammal%2C+M+B%3BLakshmi%2C+V+M%3BZenser%2C+T+V%3BDavis%2C+B+B%3BWhite%2C+E&rft.aulast=Mattammal&rft.aufirst=M&rft.date=1988-05-01&rft.volume=15&rft.issue=9&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Biomedical+%26+environmental+mass+spectrometry&rft.issn=08876134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-09 N1 - Date created - 1988-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neoplastic associations of rheumatic diseases and rheumatic manifestations of cancer. AN - 78259363; 3288324 AB - Associations between rheumatic diseases and malignant neoplasms are still inferential and based largely on epidemiologic data. Rheumatoid arthritis predisposes weakly to the occurrence of lymphoreticular neoplasms. This is more clearly true of Sjögren's disease, whether or not it is associated with RA. A subset of DM/PM which becomes manifest in close temporal proximity to a neoplasm may be a paraneoplastic reaction, but DM/PM, in general, does not predispose to neoplasia. Scleroderma in its early phase is associated with the development of breast cancer in women, and after a decade or longer, if pulmonary fibrosis has developed, with lung cancer. Of the drugs that have been used to treat these diseases, cyclophosphamide is most strongly implicated as a carcinogenic agent, particularly inducing lymphoreticular neoplasms and carcinoma of the bladder. Musculoskeletal symptoms that may be clues to the existence of cancer may either be caused by invasion of the neoplasm or be mediated by unidentified neurohumoral mechanisms. Except for multiple myeloma, primary neoplasms of skeletal tissues tend to occur under the age of 50 years. Metastatic disease occurs congruently with the age incidence of the primary neoplasm. Metastases may mimic mono- or oligoarticular arthritis if they happen to be periarticular or synovial. These metastases result most often from carcinoma of the lung or, in women, carcinoma of the breast. Hypertrophic pulmonary osteoarthropathy usually is due to carcinomas of the lung other than the small cell variety, and infrequently from other intrathoracic primary or secondary neoplasms. RA may be mimicked. Both skeletal metastases and HPOA are detected with greater sensitivity, but not specificity, by isotopic scanning techniques than by radiography. Of the other paraneoplastic musculoskeletal syndromes, neuromyopathy is the most frequent. It must be distinguished from cachexia, polymyositis, polymyalgia rheumatica, and the myasthenic syndrome. Both neuromyopathy and Eaton-Lambert (myasthenic) syndrome are predominantly associated with small cell carcinoma of the lung and both are best diagnosed by electromyography. Carcinomatous polyarthritis and the palmar fasciitis-arthritis syndrome occur with various neoplasms, although the latter appears to be particularly associated with ovarian carcinomas. The paraneoplastic arthritides test negatively for the rheumatoid factor, but no reliable positive immunochemical clues have as yet been identified. JF - Clinics in geriatric medicine AU - Benedek, T G AD - Department of Medicine, Veterans Administration Hospital, University of Pittsburgh School of Medicine, Pennsylvania. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 333 EP - 355 VL - 4 IS - 2 SN - 0749-0690, 0749-0690 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Neoplasms -- complications KW - Rheumatic Diseases -- complications KW - Neoplasms -- epidemiology KW - Rheumatic Diseases -- etiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78259363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+geriatric+medicine&rft.atitle=Neoplastic+associations+of+rheumatic+diseases+and+rheumatic+manifestations+of+cancer.&rft.au=Benedek%2C+T+G&rft.aulast=Benedek&rft.aufirst=T&rft.date=1988-05-01&rft.volume=4&rft.issue=2&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Clinics+in+geriatric+medicine&rft.issn=07490690&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-28 N1 - Date created - 1988-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Myelopathy after the intrathecal administration of hypertonic saline. AN - 78256994; 3380287 AB - The neuropathological effects of intrathecally administered hypertonic saline have not been described previously. We report a patient who, within a day of receiving 20 ml of hypertonic (7.5%) saline intrathecally, developed flaccid paraplegia and complete sensory loss below the umbilicus. Subsequently, there was some transitory return of motor and coarse sensory function. The patient died 16 months after the injection. At autopsy, there was peripherally accentuated loss of myelinated fibers within the spinal cord from T12 downward, as well as dense collagenous thickening of the dorsal leptomeninges from T9 to T11. The findings in this case, coupled with observations made by others, serve to emphasize the need for extreme caution whenever planning any form of intrathecal therapy. JF - Neurosurgery AU - Kim, R C AU - Porter, R W AU - Choi, B H AU - Kim, S W AD - Laboratory Service, Veterans Administration Medical Center, Long Beach, California. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 942 EP - 945 VL - 22 IS - 5 SN - 0148-396X, 0148-396X KW - Saline Solution, Hypertonic KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Pain -- drug therapy KW - Sodium Chloride -- adverse effects KW - Paraplegia -- pathology KW - Saline Solution, Hypertonic -- administration & dosage KW - Spinal Cord -- pathology KW - Paraplegia -- chemically induced KW - Saline Solution, Hypertonic -- adverse effects KW - Injections, Spinal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78256994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgery&rft.atitle=Myelopathy+after+the+intrathecal+administration+of+hypertonic+saline.&rft.au=Kim%2C+R+C%3BPorter%2C+R+W%3BChoi%2C+B+H%3BKim%2C+S+W&rft.aulast=Kim&rft.aufirst=R&rft.date=1988-05-01&rft.volume=22&rft.issue=5&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Neurosurgery&rft.issn=0148396X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-21 N1 - Date created - 1988-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of methotrexate in steroid-resistant systemic lupus erythematosus. AN - 78254329; 3288223 AB - Although the use of methotrexate (MTX) is gaining acceptance in the treatment of several connective tissue diseases, there is little evidence of its therapeutic value in systemic lupus erythematosus (SLE). We examined the response to MTX in patients with steroid-resistant SLE in an open, unblinded study. Of 10 SLE patients treated with MTX (7.5 mg/weekly), 7 showed improvement. The other 3 stopped therapy because of lack of response or because of side effects. Improvements were noted within 3 months in responding patients. These promising observations suggest that controlled studies of MTX for the treatment of SLE are justified. JF - Arthritis and rheumatism AU - Rothenberg, R J AU - Graziano, F M AU - Grandone, J T AU - Goldberg, J W AU - Bjarnason, D F AU - Finesilver, A G AD - Rheumatology Service, William S. Middleton Memorial Veterans Administration Hospital, Madison, WI 53705. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 612 EP - 615 VL - 31 IS - 5 SN - 0004-3591, 0004-3591 KW - Steroids KW - 0 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Abridged Index Medicus KW - Index Medicus KW - Ulcer -- chemically induced KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Mouth Diseases -- chemically induced KW - Gastrointestinal Diseases -- chemically induced KW - Drug Resistance KW - Middle Aged KW - Adolescent KW - Steroids -- therapeutic use KW - Methotrexate -- adverse effects KW - Lupus Erythematosus, Systemic -- drug therapy KW - Methotrexate -- therapeutic use KW - Lupus Erythematosus, Systemic -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78254329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=The+use+of+methotrexate+in+steroid-resistant+systemic+lupus+erythematosus.&rft.au=Rothenberg%2C+R+J%3BGraziano%2C+F+M%3BGrandone%2C+J+T%3BGoldberg%2C+J+W%3BBjarnason%2C+D+F%3BFinesilver%2C+A+G&rft.aulast=Rothenberg&rft.aufirst=R&rft.date=1988-05-01&rft.volume=31&rft.issue=5&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-24 N1 - Date created - 1988-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of alcoholism and liver disease in the appearance of serum antibodies against acetaldehyde adducts. AN - 78229202; 3371872 AB - We recently presented preliminary data indicating the presence of antibodies against acetaldehyde adducts in sera of over 70% of alcoholic patients. To assess the respective roles of liver disease and alcohol consumption as well as the specificity of this immune response, 141 patients in various stages of alcoholic and nonalcoholic liver diseases were tested by a hemagglutination assay. Sixty-three (73%) of 86 alcoholics had antibody titers above control levels (p less than 0.0001). Alcohol consumption of these individuals was significantly higher (p less than 0.001) than that of those alcoholics with normal titers. Twenty-two patients (39%) with nonalcoholic liver diseases also had elevated levels of antibodies against acetaldehyde adducts (p less than 0.0005); of these, 8 had primary biliary cirrhosis (7 in Stages III and IV), 9 had chronic active hepatitis (6 with cirrhosis) and 5 had acute (virus- or drug-induced) hepatitis. Antibody titers did not correlate with levels of transaminase or alkaline phosphatase activity, nor with bilirubin, and albumin. However, in 52 alcoholics and in nonalcoholic patients with biopsy-confirmed liver disease, the highest titers were seen in the more advanced stages of liver damage. Thus, in addition to alcohol consumption, severity of liver disease may play a role in the appearance of circulating antibodies against acetaldehyde adducts. JF - Hepatology (Baltimore, Md.) AU - Hoerner, M AU - Behrens, U J AU - Worner, T M AU - Blacksberg, I AU - Braly, L F AU - Schaffner, F AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, New York 10468. PY - 1988 SP - 569 EP - 574 VL - 8 IS - 3 SN - 0270-9139, 0270-9139 KW - Antibodies KW - 0 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Antibody Specificity KW - Liver -- pathology KW - Humans KW - Biopsy KW - Hemagglutination Tests KW - Hemagglutination Inhibition Tests KW - Liver Diseases -- immunology KW - Acetaldehyde -- immunology KW - Alcoholism -- immunology KW - Antibodies -- analysis KW - Liver Diseases, Alcoholic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78229202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=The+role+of+alcoholism+and+liver+disease+in+the+appearance+of+serum+antibodies+against+acetaldehyde+adducts.&rft.au=Hoerner%2C+M%3BBehrens%2C+U+J%3BWorner%2C+T+M%3BBlacksberg%2C+I%3BBraly%2C+L+F%3BSchaffner%2C+F%3BLieber%2C+C+S&rft.aulast=Hoerner&rft.aufirst=M&rft.date=1988-05-01&rft.volume=8&rft.issue=3&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-30 N1 - Date created - 1988-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute hemodynamic effects of intravenous isradipine. AN - 78202876; 2966552 AB - The acute hemodynamic effects of isradipine, a new dihydropyridine calcium antagonist, were evaluated in 16 men referred for elective cardiac catheterization. Low-dose (0.007 mg/kg, n = 8) and high-dose (0.015 mg/kg, n = 8) isradipine was administered intravenously over 10 minutes and the hemodynamic alterations assessed 10 minutes after completion of infusion. Low-dose isradipine caused increases in heart rate (68 +/- 9 to 79 +/- 12 beats/min, p less than 0.001) (mean +/- standard deviation), cardiac index (3.0 +/- 0.7 to 4.1 +/- 0.9 liter/min/m2, p less than 0.001) and coronary sinus blood flow (114 +/- 27 to 162 +/- 74 ml/min, p less than 0.01), and significant decreases in mean aortic pressure (104 +/- 17 to 92 +/- 10 mm Hg, p less than 0.01), systemic and coronary vascular resistance. High-dose isradipine caused similar effects: the heart rate increased (72 +/- 6 to 84 +/- 14 beats/min, p less than 0.005), as did the cardiac index (3.0 +/- 0.6 to 4.6 +/- 0.9 liter/min/m2, p less than 0.001) and coronary sinus blood flow (122 +/- 48 to 166 +/- 47 ml/min, p less than 0.025). In addition, there were increases in the stroke volume index (43 +/- 10 to 55 +/- 8 ml/m2, p less than 0.001) and left ventricular stroke work index (69 +/- 12 to 79 +/- 12 g-m/m2, p = 0.05) after the high-dose infusion. Vascular resistance declined significantly in the systemic, pulmonary and coronary beds.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of cardiology AU - van den Berg, E K AU - Dehmer, G J AD - Cardiac Catheterization Laboratory, Dallas Veterans Administration Medical Center, Texas 75216. Y1 - 1988/05/01/ PY - 1988 DA - 1988 May 01 SP - 1102 EP - 1105 VL - 61 IS - 13 SN - 0002-9149, 0002-9149 KW - Antihypertensive Agents KW - 0 KW - Calcium Channel Blockers KW - Pyridines KW - Isradipine KW - YO1UK1S598 KW - Abridged Index Medicus KW - Index Medicus KW - Infusions, Intravenous KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Heart -- drug effects KW - Aged KW - Myocardial Contraction -- drug effects KW - Middle Aged KW - Male KW - Hemodynamics -- drug effects KW - Pyridines -- administration & dosage KW - Calcium Channel Blockers -- pharmacology KW - Calcium Channel Blockers -- adverse effects KW - Antihypertensive Agents -- adverse effects KW - Calcium Channel Blockers -- administration & dosage KW - Antihypertensive Agents -- administration & dosage KW - Antihypertensive Agents -- pharmacology KW - Pyridines -- pharmacology KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78202876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Acute+hemodynamic+effects+of+intravenous+isradipine.&rft.au=van+den+Berg%2C+E+K%3BDehmer%2C+G+J&rft.aulast=van+den+Berg&rft.aufirst=E&rft.date=1988-05-01&rft.volume=61&rft.issue=13&rft.spage=1102&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-27 N1 - Date created - 1988-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nosocomial transmission of tuberculosis from unsuspected disease. AN - 78200381; 3364442 AB - Tuberculosis remains an occupational hazard for hospital employees. A case of acute generalized tuberculosis occurring in a patient with a malignancy who had received corticosteroids was undetected during life and during a gross autopsy examination. Histologic examination of tissue performed one month later was necessary to establish the diagnosis. Of susceptible hospital staff members who were exposed to the index case, infection developed in nine of 56 (16 percent) compared with three of 333 (0.9 percent) unexposed personnel with similar risk but no known exposure (p less than 0.001). This was a 17.8-fold increase in the infection rate for the exposed group. Three employees infected had evidence of active disease: two had pleural effusions and one had cavitary pulmonary infiltrates; six were asymptomatic. The high rate of infection was associated with inadequate air ventilation and exposure to uncontained infectious aerosol. Preventive therapy with isoniazid, high-change-ventilating systems, ultraviolet radiation, and primary barrier systems are recommended methods to reduce the infection risk. JF - The American journal of medicine AU - Kantor, H S AU - Poblete, R AU - Pusateri, S L AD - Laboratory Service, Veterans Administration Medical Center, North Chicago, Illinois 60064. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 833 EP - 838 VL - 84 IS - 5 SN - 0002-9343, 0002-9343 KW - Abridged Index Medicus KW - Index Medicus KW - Autopsy KW - Ventilation KW - Risk Factors KW - Humans KW - Middle Aged KW - Air Microbiology KW - Tuberculin Test KW - Male KW - Personnel, Hospital KW - Cross Infection -- transmission KW - Occupational Diseases -- transmission KW - Tuberculosis, Pulmonary -- transmission KW - Tuberculosis, Pulmonary -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78200381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Nosocomial+transmission+of+tuberculosis+from+unsuspected+disease.&rft.au=Kantor%2C+H+S%3BPoblete%2C+R%3BPusateri%2C+S+L&rft.aulast=Kantor&rft.aufirst=H&rft.date=1988-05-01&rft.volume=84&rft.issue=5&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Triiodothyronine inhibits phorbol ester-induced thyrotropin release from elutriated bovine thyrotrophs. AN - 78198105; 3129280 AB - The inhibitory effect of T3 on TSH release was studied on a population of thyrotroph-enriched cells prepared from bovine pituitary glands by centrifugal elutriation. The cells (2.0 X 10(5)/ml) were cultured for 2 days and then exposed to TRH, phorbol-12 myristate-13 acetate (PMA), or calcium ionophore (A23187) with or without 100 nM T3 for two different preincubation periods, 3 h and 24 h. Cytosolic TSH and release of TSH into the medium were measured by a specific RIA for bovine TSH. TRH (10 nM, 100 nM), PMA (100 nM, 1 microM, 10 microM), and A23187 (100 nM, 1 microM, 10 microM) increased TSH release in a dose-dependent manner. One-hundred nanomolar TRH, 10 microM PMA, and 10 microM A23187 increased TSH release maximally from 176 +/- 6 microU/ml (mean +/- SD, n = 4) to 240 +/- 40, 308 +/- 39, and 228 +/- 16, respectively. PMA and A23187 interacted synergistically in the release of TSH. Cytosolic TSH was not affected by TRH or A23187. PMA (100 nM) together with A23187 resulted in a decrease in cytosolic TSH. PMA alone (1 and 10 microM) decreased cytosolic TSH content to 84% and 77%, respectively, of the control level, suggesting that PMA enhances release of TSH. One-hundred nanomolar T3 had no effect on the basal release of TSH when given for 3 h, but resulted in a 47% decrease when administered for 24 h. The inhibitory effect of T3 on TRH-induced TSH release was found when the cells were preincubated with T3 for 24 h, but not for 3 h. In contrast, PMA-induced TSH release was significantly inhibited to 74% of induced levels by preincubation with T3 even for 3 h, and further inhibition occurred with an increase in preincubation time. These data suggest that the effectiveness of T3 depends on the mode of stimulation, and that the more immediate reaction observed with PMA induction may result from the interaction of T3 with the protein kinase C pathway. JF - Endocrinology AU - Yanagisawa, M AU - Mirell, C J AU - Hershman, J M AD - Endocrinology Research Laboratory, Wadsworth Veterans Administration Medical Center, Los Angeles, California 90073. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 2121 EP - 2126 VL - 122 IS - 5 SN - 0013-7227, 0013-7227 KW - Triiodothyronine KW - 06LU7C9H1V KW - Calcimycin KW - 37H9VM9WZL KW - Thyrotropin KW - 9002-71-5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cattle KW - Cells, Cultured KW - Kinetics KW - Calcimycin -- pharmacology KW - Pituitary Gland, Anterior -- drug effects KW - Triiodothyronine -- pharmacology KW - Thyrotropin -- secretion KW - Pituitary Gland, Anterior -- secretion KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pituitary Gland, Anterior -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78198105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Triiodothyronine+inhibits+phorbol+ester-induced+thyrotropin+release+from+elutriated+bovine+thyrotrophs.&rft.au=Yanagisawa%2C+M%3BMirell%2C+C+J%3BHershman%2C+J+M&rft.aulast=Yanagisawa&rft.aufirst=M&rft.date=1988-05-01&rft.volume=122&rft.issue=5&rft.spage=2121&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-01 N1 - Date created - 1988-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations in rabbit renal microvascular prostanoid synthesis in acute renal failure. AN - 78193385; 3364578 AB - Vasodepressor prostanoids have been suggested to regulate renal hemodynamics after nephrotoxic injury and thus protect the kidney against the effects of prolonged ischemia. This study assessed whether changes in two microvascular vasodilator prostanoids would correlate with changes seen in renal hemodynamics in rabbits with nephrotoxic renal injury produced by either uranyl nitrate or mercuric chloride. Rabbits were killed at 3, 24, and 72 h after the nephrotoxin injections and 6-ketoprostaglandin (PG) F1 alpha and PGE2 synthesis was measured in vitro in isolated renal microvessels. At the end of 24 h, synthesis of both prostanoids was significantly increased in all nephrotoxin-treated animals, an observation not noted at the end of 3 h. At 72 h, 6-keto-PGF1 alpha production remained elevated. Pretreatment with mepacrine blocked the increased prostanoid production seen in uranyl nitrate-treated animals. Thus, renal microvascular vasodilator prostanoid biosynthesis is increased 24-72 h after nephrotoxin administration. These data suggest that the biosynthesis of prostacyclin and PGE2 may contribute to the maintenance of renal blood flow in the first few days after acute renal injury and further suggest that a mechanism for this increase may be stimulation of phospholipase A2. JF - The American journal of physiology AU - Chaudhari, A AU - Kirschenbaum, M A AD - Nephrology Section, Long Beach Veterans Administration Medical Center, California. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - F684 EP - F688 VL - 254 IS - 5 Pt 2 SN - 0002-9513, 0002-9513 KW - Fatty Acids KW - 0 KW - Prostanoic Acids KW - Uranyl Nitrate KW - 0C0WI17JYF KW - Mercuric Chloride KW - 53GH7MZT1R KW - 6-Ketoprostaglandin F1 alpha KW - 58962-34-8 KW - Index Medicus KW - Animals KW - Uranyl Nitrate -- pharmacology KW - Rabbits KW - 6-Ketoprostaglandin F1 alpha -- biosynthesis KW - Microcirculation KW - Mercuric Chloride -- pharmacology KW - Male KW - Arterioles -- metabolism KW - Fatty Acids -- biosynthesis KW - Kidney -- blood supply KW - Arteries -- drug effects KW - Prostanoic Acids -- biosynthesis KW - Acute Kidney Injury -- metabolism KW - Arterioles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78193385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Alterations+in+rabbit+renal+microvascular+prostanoid+synthesis+in+acute+renal+failure.&rft.au=Chaudhari%2C+A%3BKirschenbaum%2C+M+A&rft.aulast=Chaudhari&rft.aufirst=A&rft.date=1988-05-01&rft.volume=254&rft.issue=5+Pt+2&rft.spage=F684&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Histoplasmosis in patients at risk for the acquired immunodeficiency syndrome in a nonendemic setting. AN - 78183008; 3359846 AB - We reviewed 18 cases of histoplasmosis in patients at risk for the acquired immunodeficiency syndrome seen at two New York City hospitals in the past 3 1/2 years. Seventeen patients were Hispanic, including 13 born in Puerto Rico and three in South America. Clinical presentation was subacute, with high fever, weight loss, and mild respiratory symptoms with well-maintained gas exchange. Five patients had normal chest roentgenograms. The most common chest roentgenographic abnormality was diffuse small nodules. A rapid diagnosis was established histologically in 72 percent of patients, most commonly by transbronchial lung biopsy; cultures were positive in 94 percent of patients while serology was positive in five of six patients. Mycobacterium tuberculosis was a concurrent, often unrecognized, pathogen in six cases. Most patients responded to amphotericin therapy. Histoplasmosis may represent an early sign of altered host immunity in the acquired immunodeficiency syndrome. JF - Chest AU - Salzman, S H AU - Smith, R L AU - Aranda, C P AD - Bellevue Chest Service, New York Veterans Administration Medical Center, New York. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 916 EP - 921 VL - 93 IS - 5 SN - 0012-3692, 0012-3692 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Puerto Rico -- ethnology KW - Homosexuality KW - New York City KW - HIV Seropositivity KW - Hispanic Americans KW - Risk Factors KW - Adult KW - Substance-Related Disorders KW - South America -- ethnology KW - Middle Aged KW - Tuberculosis, Pulmonary -- epidemiology KW - Male KW - Histoplasmosis -- epidemiology KW - Acquired Immunodeficiency Syndrome -- complications KW - Histoplasmosis -- etiology KW - Lung Diseases, Fungal -- etiology KW - Lung Diseases, Fungal -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78183008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Histoplasmosis+in+patients+at+risk+for+the+acquired+immunodeficiency+syndrome+in+a+nonendemic+setting.&rft.au=Salzman%2C+S+H%3BSmith%2C+R+L%3BAranda%2C+C+P&rft.aulast=Salzman&rft.aufirst=S&rft.date=1988-05-01&rft.volume=93&rft.issue=5&rft.spage=916&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The cardiac glycoside digoxin does not alter the activity of human polymorphonuclear leukocytes in vitro. AN - 78172966; 2834461 JF - The Journal of infectious diseases AU - Esposito, A L AU - Clark, C A AU - Poirier, W J AD - Department of Medicine, Boston Veterans Administration Medical Center 02130. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 1084 EP - 1089 VL - 157 IS - 5 SN - 0022-1899, 0022-1899 KW - Opsonin Proteins KW - 0 KW - Superoxides KW - 11062-77-4 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Digoxin KW - 73K4184T59 KW - Zymosan KW - 9010-72-4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Chemotaxis, Leukocyte -- drug effects KW - Zymosan -- pharmacology KW - Kinetics KW - Humans KW - Adult KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Blood Bactericidal Activity -- drug effects KW - Superoxides -- blood KW - Neutrophils -- drug effects KW - Neutrophils -- physiology KW - Digoxin -- blood KW - Digoxin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78172966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=The+cardiac+glycoside+digoxin+does+not+alter+the+activity+of+human+polymorphonuclear+leukocytes+in+vitro.&rft.au=Esposito%2C+A+L%3BClark%2C+C+A%3BPoirier%2C+W+J&rft.aulast=Esposito&rft.aufirst=A&rft.date=1988-05-01&rft.volume=157&rft.issue=5&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-01 N1 - Date created - 1988-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Systemic talc granulomatosis associated with disseminated histoplasmosis in a drug abuser. AN - 78163564; 3358658 AB - A 32-year-old intravenous drug abuser was found to have systemic talc granulomatosis and disseminated histoplasmosis. The clinicopathologic findings of this case support the hypothesis that the patient was predisposed to disseminated histoplasmosis by repeated intravenous talc administration. The effects of silica, a close relative of talc, on macrophages and the role of macrophages in recovery from Histoplasma capsulatum infection are described. JF - Archives of pathology & laboratory medicine AU - Racela, L S AU - Papasian, C J AU - Watanabe, I AU - McGregor, D H AU - Lee, S H AU - Talley, R AD - Laboratory Service, Veterans Administration Medical Center, Kansas City, MO 64128. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 557 EP - 560 VL - 112 IS - 5 SN - 0003-9985, 0003-9985 KW - Talc KW - 14807-96-6 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Substance-Related Disorders KW - Immunity -- drug effects KW - Male KW - Histoplasmosis -- immunology KW - Granuloma -- complications KW - Bone Marrow Diseases -- pathology KW - Granuloma -- pathology KW - Bone Marrow Diseases -- etiology KW - Histoplasmosis -- pathology KW - Granuloma -- etiology KW - Histoplasmosis -- etiology KW - Granuloma -- immunology KW - Talc -- adverse effects KW - Bone Marrow Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78163564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=Systemic+talc+granulomatosis+associated+with+disseminated+histoplasmosis+in+a+drug+abuser.&rft.au=Racela%2C+L+S%3BPapasian%2C+C+J%3BWatanabe%2C+I%3BMcGregor%2C+D+H%3BLee%2C+S+H%3BTalley%2C+R&rft.aulast=Racela&rft.aufirst=L&rft.date=1988-05-01&rft.volume=112&rft.issue=5&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=00039985&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-24 N1 - Date created - 1988-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Direct staining and visualization of endothelial monolayers cultured on synthetic polycarbonate filters. AN - 78163356; 3356897 AB - Endothelial and epithelial cells cultured on synthetic filter supports have been used to study permeability and transport under various experimental conditions. However, because of the non-transparent nature of these filters, morphological studies using light microscopy are not possible. Presently, investigators circumvent this problem by using cells cultured on glass coverslips, extrapolating morphological data from a system clearly different from that used for functional studies. We describe here a useful technique for direct staining and visualization of cells grown on polycarbonate filter supports, using fluorochrome probes and fluorescence microscopy. We have utilized acridine orange, rhodamine phalloidin, and an anti-vimentin monoclonal antibody to provide information about cell shape, monolayer configuration, and cytoskeletal protein distribution in cultured calf pulmonary artery endothelial cell monolayers. Comparison staining of coverslip and filter preparations revealed a number of clear differences in these parameters. This technique should enable investigators to perform the necessary studies to obtain direct correlations between functional and morphological data. JF - The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society AU - Phillips, P G AU - Tsan, M F AD - Research Service, Albany Veterans Administration Medical Center, New York 12208. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 551 EP - 554 VL - 36 IS - 5 SN - 0022-1554, 0022-1554 KW - Actins KW - 0 KW - Dental Cements KW - Polycarboxylate Cement KW - Vimentin KW - polycarbonate KW - 25766-59-0 KW - Acridine Orange KW - F30N4O6XVV KW - Index Medicus KW - Vimentin -- analysis KW - Animals KW - Filtration KW - Cattle KW - Cells, Cultured KW - Actins -- analysis KW - Endothelium, Vascular -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78163356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+histochemistry+and+cytochemistry+%3A+official+journal+of+the+Histochemistry+Society&rft.atitle=Direct+staining+and+visualization+of+endothelial+monolayers+cultured+on+synthetic+polycarbonate+filters.&rft.au=Phillips%2C+P+G%3BTsan%2C+M+F&rft.aulast=Phillips&rft.aufirst=P&rft.date=1988-05-01&rft.volume=36&rft.issue=5&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=The+journal+of+histochemistry+and+cytochemistry+%3A+official+journal+of+the+Histochemistry+Society&rft.issn=00221554&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-25 N1 - Date created - 1988-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Incidence and nature of tumors induced in Sprague-Dawley rats by gamma-irradiation. AN - 78162309; 3281750 AB - In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiments here reported suggest that 2 consecutive total-body gamma-irradiations of 150 rads each are sufficient to induce in rats the development of tumors, some malignant; 18 of 19 females (94.7%) developed tumors at an average age of 11.4 mo, and seven of the 14 males in this group (50%) developed tumors at an average age of 10.4 mo. In the second group, which received 3 consecutive gamma-irradiations, 20 of 23 females (86.9%) and 5 of 13 males (38.4%) developed tumors at average ages of 9.1 and 7.5 mo, respectively. In the third group, among rats which received 4 consecutive gamma-irradiations, 17 of 19 females (89.4%) and 4 of 12 males (33.3%) developed tumors at average ages of 9.4 and 10.5 mo, respectively. The etiology of tumors either developing spontaneously or induced by irradiation in rats remains to be clarified. Our attempts to detect virus particles by electron microscopy in such tumors or lymphomas have not been successful. As a working hypothesis, we are tempted to theorize that tumors or lymphomas developing spontaneously or induced by gamma irradiation in rats are caused by latent viral agents which are integrated into the cell genome and are cell associated, i.e., not separable from the rat tumor cells by conventional methods thus far used. JF - Cancer research AU - Gross, L AU - Dreyfuss, Y AU - Faraggiana, T AD - Cancer Research Unit, Veterans Administration Medical Center, Bronx, New York 10468. Y1 - 1988/05/01/ PY - 1988 DA - 1988 May 01 SP - 2451 EP - 2453 VL - 48 IS - 9 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Whole-Body Irradiation KW - Lymphoma -- etiology KW - Sex Factors KW - Gamma Rays KW - Leukemia, Radiation-Induced -- etiology KW - Male KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78162309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Incidence+and+nature+of+tumors+induced+in+Sprague-Dawley+rats+by+gamma-irradiation.&rft.au=Gross%2C+L%3BDreyfuss%2C+Y%3BFaraggiana%2C+T&rft.aulast=Gross&rft.aufirst=L&rft.date=1988-05-01&rft.volume=48&rft.issue=9&rft.spage=2451&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-18 N1 - Date created - 1988-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Analysis of the Education Program Approval Process: A Program Evaluation. AN - 63023176; ED319964 AB - A study of the education program approval process involving the Veterans Administration (VA) and the State Approving Agencies (SAAs) had the following objectives: to describe the present education program approval process; to determine time and costs associated with the education program approval process; to describe the approval process at another federal agency; and to develop models of exemplary activities for the process of education program approval. Data were gathered from Department of Veterans Benefits (DVB) management and statistical recurring reports; personal interviews with VA central office and regional office personnel, staff members of SAAs, the U.S. Department of Labor, and the U.S. Department of Education; and survey questionnaires. Among the findings of the study were the following: veteran students primarily attend institutes of higher learning; placement of SAAs in state organizations varies; funding of the SAA function is not timely; there is regional variation in education program approval workload and productivity; capability to share data electronically is not used; the optimal staff size of a SAA office is four professionals; the Department of Labor approves and registers apprenticeship programs nationwide; and the Department of Education recognizes accrediting agencies that judge the quality of an educational institution or program. (The document includes 32 data tables, 7 exhibits, 5 appendices, and an 18-item bibliography.) (CML) AU - Fountaine, Charles A. Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 135 KW - ERIC, Resources in Education (RIE) KW - Access to Education KW - Educational Administration KW - Educational Finance KW - Higher Education KW - Adults KW - Veterans KW - Student Financial Aid KW - Accreditation (Institutions) KW - Federal Programs KW - Program Evaluation KW - Fringe Benefits KW - Veterans Education KW - Education Work Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63023176?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Effects of Psychophysical Stress on Surgical Outcome AN - 61534814; 198801439 AB - To determine the effects of stress on immune status & surgical outcome in 24 healthy Ms undergoing hernia repair, stressful life events over the previous 6 months & levels of social support were assessed at time of admission. Surgical outcomes were assessed by length of stay, narcotics used, & covariance where one factor was life stress & the other was response to a cold pressor test. Age & social support were covaried in comparing immune responses before surgery. The findings suggest that high psychological & physiological stress responses before surgery lead to poorer outcomes even in otherwise healthy Ms undergoing relatively simple elective surgical procedures. 6 Tables, 6 Figures, 26 References. Modified HA JF - Psychosomatic Medicine AU - Linn, Bernard S AU - Linn, Margaret W AU - Klimas, Nancy G AD - Veterans Administration Medical Center, 1201 NW 16th St Miami FL 33215 Y1 - 1988/05// PY - 1988 DA - May 1988 SP - 230 EP - 244 VL - 50 IS - 3 SN - 0033-3174, 0033-3174 KW - immune status/surgical outcome, male hernia repair patients KW - stress KW - hospital records/tests KW - Psychological Stress KW - Males KW - Surgery KW - Health KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61534814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Effects+of+Psychophysical+Stress+on+Surgical+Outcome&rft.au=Linn%2C+Bernard+S%3BLinn%2C+Margaret+W%3BKlimas%2C+Nancy+G&rft.aulast=Linn&rft.aufirst=Bernard&rft.date=1988-05-01&rft.volume=50&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Surgery; Health; Males ER - TY - JOUR T1 - Pseudomonas aeruginosa cytotoxin stimulates secretion of amylase and protease zymogens with a concomitant decrease of mRNA levels in isolated rat pancreatic acini. AN - 78201028; 2452633 AB - The action of Pseudomonas aeruginosa cytotoxin on isolated pancreatic acini was investigated. The release of amylase and serine protease zymogens from the isolated rat pancreatic acini was induced with increasing amounts of cytotoxin in vitro. The stimulated release of amylase reached 30% of total cellular content with 100 micrograms/mL of the purified cytotoxin. The induced release of amylase, trypsinogen, proelastase, and chymotrypsinogen reached the maximum after 75 minutes of incubation while lactate dehydrogenase began to appear after 15 minutes of incubation with a secondary biphasic increase at 75 min of incubation. The concentrations of acinar mRNAs of amylase, trypsinogen, proelastase, and chymotrypsinogen, as measured by dot-blot hybridization with the cloned cDNAs of amylase, trypsinogen I, proelastase II, and chymotrypsinogen B of the rat, decreased with time and were significantly lower than in the untreated acini. It is concluded that cytotoxin stimulates the release of amylase and protease zymogens with a concomitant increase in membrane permeability and a decrease of cellular mRNA levels. The inhibition of gene expression is attributable merely to a generalized toxic effect upon cellular metabolism. JF - Biochemical and biophysical research communications AU - Lau, P P AU - Palmer, R L AU - Lambert, H C AU - Song, C S AU - Lutz, F AU - Geokas, M C AD - Department of Medicine, Veterans Administration Medical Center, Martinez, CA. Y1 - 1988/04/29/ PY - 1988 DA - 1988 Apr 29 SP - 688 EP - 694 VL - 152 IS - 2 SN - 0006-291X, 0006-291X KW - Bacterial Toxins KW - 0 KW - Cytotoxins KW - Enzyme Precursors KW - RNA, Messenger KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Amylases KW - EC 3.2.1.- KW - Peptide Hydrolases KW - EC 3.4.- KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Enzyme Precursors -- secretion KW - Cell Membrane Permeability -- drug effects KW - Kinetics KW - Bacterial Toxins -- pharmacology KW - L-Lactate Dehydrogenase -- secretion KW - Male KW - RNA, Messenger -- metabolism KW - Pancreas -- metabolism KW - Cytotoxins -- physiology KW - Pseudomonas aeruginosa -- physiology KW - Peptide Hydrolases -- secretion KW - Pancreas -- enzymology KW - Amylases -- secretion KW - RNA, Messenger -- biosynthesis KW - Pancreas -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78201028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Pseudomonas+aeruginosa+cytotoxin+stimulates+secretion+of+amylase+and+protease+zymogens+with+a+concomitant+decrease+of+mRNA+levels+in+isolated+rat+pancreatic+acini.&rft.au=Lau%2C+P+P%3BPalmer%2C+R+L%3BLambert%2C+H+C%3BSong%2C+C+S%3BLutz%2C+F%3BGeokas%2C+M+C&rft.aulast=Lau&rft.aufirst=P&rft.date=1988-04-29&rft.volume=152&rft.issue=2&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. AN - 78157647; 3258601 AB - The effects of recombinant human tumor necrosis factor alpha (TNF alpha) on collagen production and gene expression in cultured fibroblasts were studied. Cells were labeled with [3H]proline, and the radioactivity of collagenase-sensitive and -resistant proteins were used to calculate the rates of protein production. The net production of collagen relative to total proteins was inhibited by TNF alpha (0-1.2 nM) in a dose- and time-related manner. The specific activities of the free [3H]proline pool, which were similar in control and TNF alpha-treated cells, were used to calculate the absolute rates of protein production. The absolute rate of collagen production was decreased by 50% in the presence of 1.2 nM TNF alpha during 24-h incubations (851 +/- 104 versus 426 +/- 39 pmol/micrograms of DNA/h; p less than 0.01), whereas noncollagen protein production and the rate of procollagen secretion were unchanged. We found no evidence of cellular toxicity in cultured cells treated with TNF alpha. In addition, TNF alpha did not affect cell proliferation as determined by [6-3H]thymidine incorporation into DNA. Most of the collagen produced by the cultured fibroblasts was type I. Using hybridization with specific DNA probes there was an approximately 50% decrease in the quantity of procollagen alpha 1(I) mRNA, without changes in the quantity of alpha tubulin mRNA or the size of the transcripts, in cells incubated with TNF alpha. Interleukin-1 (2.5 ng/ml) also decreased the levels of procollagen alpha 1(I) mRNA by approximately 50%. Cycloheximide (0.1 mM), an inhibitor of protein synthesis, blocked the inhibitory effect of both TNF alpha and interleukin-1 on procollagen alpha 1(I) mRNA. Nuclear run-off assays demonstrated that TNF alpha decreased procollagen alpha 1(I) transcriptional activity by 50% and had no effects on alpha tubulin gene transcription. Thus, TNF alpha decreases collagen gene transcription, collagen mRNA levels, and collagen production in cultured fibroblasts. JF - The Journal of biological chemistry AU - Solis-Herruzo, J A AU - Brenner, D A AU - Chojkier, M AD - Department of Medicine, Veterans Administration Medical Center, San Diego, California. Y1 - 1988/04/25/ PY - 1988 DA - 1988 Apr 25 SP - 5841 EP - 5845 VL - 263 IS - 12 SN - 0021-9258, 0021-9258 KW - Interleukin-1 KW - 0 KW - Procollagen KW - RNA, Messenger KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Collagen KW - 9007-34-5 KW - Cycloheximide KW - 98600C0908 KW - Proline KW - 9DLQ4CIU6V KW - Index Medicus KW - Proline -- metabolism KW - Interleukin-1 -- pharmacology KW - Recombinant Proteins -- pharmacology KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Humans KW - Cycloheximide -- pharmacology KW - Cell Division -- drug effects KW - Nucleic Acid Hybridization KW - Procollagen -- genetics KW - Collagen -- genetics KW - Transcription, Genetic -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Collagen -- biosynthesis KW - Fibroblasts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78157647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Tumor+necrosis+factor+alpha+inhibits+collagen+gene+transcription+and+collagen+synthesis+in+cultured+human+fibroblasts.&rft.au=Solis-Herruzo%2C+J+A%3BBrenner%2C+D+A%3BChojkier%2C+M&rft.aulast=Solis-Herruzo&rft.aufirst=J&rft.date=1988-04-25&rft.volume=263&rft.issue=12&rft.spage=5841&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-18 N1 - Date created - 1988-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - VETERANS ADMINISTRATION NATIONAL CEMETERY, ALAMEDA AND MERCED COUNTIES, NORTHERN CALIFORNIA. AN - 36405762; 1811 AB - PURPOSE: Development of a national cemetery in Alameda and Merced counties in northern California is proposed to service the more than 1.0 million veterans that reside in this part of the state. The nearest open national cemeteries are at Riverside in southern California and Eagle Point in Oregon, more than 300 to 400 miles from the San Francisco and Sacramento populations. These distances are well in excess of the 50- and 100-mile radii that constitute the primary and secondary service areas for national cemeteries. Under the preferred plan, the Veterans Administration (VA) would develop a new national cemetery on a 322-acre parcel of private land located northwest of the town of Santa Nella. The site is part of a 25,000-acre ranch and presently provides nonirrigated pastureland for cattle. The land would be donated to the VA for use as a cemetery site. An estimated 530,000 veterans reside within the primary service area (50-mile radius) of the Santa Nella Site. Based on an interment rate of 3,181 per year by the year 2000, required facilities would consist of the following: an administration building containing 2,894 gross square feet (GSF), a maintenance building containing 9,526 GSF, three committal service shelters containing 600 to 700 GSF each, a public restroom containing 480 GSF, a flagpole and assembly area, a main entrance area, a roadway and parking system, a walkway, a utility distribution system, and an irrigation system. Grading, drainage, and landscaping would be required as well. The development would be phased, with the first phase involving between 50 and 60 acres. At full buildout, approximately 42 persons would be employed at the proposed cemetery. An interment rate of 12 per day is anticipated. The VA would plan the cemetery using elements such as permanent water sites, marsh habitat, and shrub and tree cover to enhance the value of the property as a wildlife habitat, while at the same time providing a scenic setting. POSITIVE IMPACTS: The cemetery would provide for up to 83,000 gravesites for veterans living in the service area. Socioeconomic benefits for the local community would include increased employment (year-round versus seasonal); increased retail sales, especially for restaurants and motels; and revenues from sales taxes. The rolling hills and almond orchards on the site would enhance the visual landscape, as would the construction of an administration building and its access roads. NEGATIVE IMPACTS: Use of the cemetery would result in a slight increase in automobile-related pollution and in the amount of fertilizers, pesticides, and herbicides in surface waters in the area. A reduction of approximately 10 percent would occur in northern Merced County's grazing land. Some degree of traffic congestion could occur during peak periods for memorial services on Memorial Day, the Fourth of July, and Veterans' Day weekends. Since McCabe Road is the only access to the site, it would require realignment to remove sharp bends and widening to two 12-foot lanes in order to accommodate increased cemetery traffic. Because statistics show that there is a more than adequate supply of interment space in the area, a new cemetery could adversely impact the private sector of the interment industry. There would be a slight decrease in property tax revenues. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), and Safe Drinking Water Act of 1974, as amended (42 U.S.C. 300(f) et seq.). PRIOR REFERENCES: For the abstract of the draft environmental impact statement, see 86-0506D, Volume 10, Number 12. JF - EPA number: 880132, 420 pages, April 25, 1988 PY - 1988 KW - Land Use KW - Agency number: SCH# 86080507 KW - Buildings KW - Cemeteries KW - Cultural Resources KW - Drainage KW - Employment KW - Grazing KW - Irrigation KW - Land Acquisitions KW - Open Space KW - Parking KW - Roads KW - Vegetation KW - Vegetation Surveys KW - Visual Resources KW - Water Quality KW - Water Resources Management KW - Wildlife Habitat KW - Wildlife Surveys KW - California KW - Federal Water Pollution Control Act of 1972, Compliance KW - National Historic Preservation Act of 1966, Compliance KW - Safe Drinking Water Act of 1974, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36405762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1988-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+ADMINISTRATION+NATIONAL+CEMETERY%2C+ALAMEDA+AND+MERCED+COUNTIES%2C+NORTHERN+CALIFORNIA.&rft.title=VETERANS+ADMINISTRATION+NATIONAL+CEMETERY%2C+ALAMEDA+AND+MERCED+COUNTIES%2C+NORTHERN+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Veterans Administration, Office of Facilities, Washington, D.C.; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Final. Preparation date: April 25, 1988 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Safety issues during antihypertensive treatment with angiotensin converting enzyme inhibitors. AN - 78640744; 3064605 AB - When captopril was first introduced, it was used in high doses for severe hypertension, often in the presence of renal insufficiency, and side effects such as proteinuria, rash, neutropenia, and altered taste sensation were noted. Upon analysis, these effects were most commonly seen in patients with renal disease, autoimmune disease, or collagen vascular disease. These complications usually reversed rapidly upon discontinuation of treatment. In contrast, the growing use of the angiotensin converting enzyme inhibitors, captopril and enalapril, for treating mild to moderate hypertension and the trend toward the use of lower doses has shown these agents to be well tolerated with a low frequency of troublesome adverse effects. In fact, the original spectrum of adverse effects has virtually disappeared with the use of lower doses in patients with uncomplicated hypertension. In low doses, the converting enzyme inhibitors produce remarkably few incidences of symptomatic discomfort; the most common is skin rash, which often responds to dosage reduction. Cough and rare occurrences of angioedema have also been reported. Moreover, evidence is evolving that indicates that the converting enzyme inhibitors may sometimes decrease proteinuria and improve renal function; these effects may be especially important in diabetic hypertensive patients. Of note, these drugs can also attenuate the unwanted metabolic side effects of concurrent diuretic treatment. JF - The American journal of medicine AU - Weber, M A AD - Hypertension Center, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1988/04/15/ PY - 1988 DA - 1988 Apr 15 SP - 16 EP - 23 VL - 84 IS - 4A SN - 0002-9343, 0002-9343 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Kidney -- drug effects KW - Neutropenia -- chemically induced KW - Taste -- drug effects KW - Angioedema -- chemically induced KW - Proteinuria -- chemically induced KW - Cough -- chemically induced KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78640744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Safety+issues+during+antihypertensive+treatment+with+angiotensin+converting+enzyme+inhibitors.&rft.au=Weber%2C+M+A&rft.aulast=Weber&rft.aufirst=M&rft.date=1988-04-15&rft.volume=84&rft.issue=4A&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The generation of oxygen radicals: a positive signal for lymphocyte activation. AN - 78197865; 3365770 AB - The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is linked to the generation of free radicals induced by PMA. Modulation of intracellular glutathione is associated lymphocyte activation and in protection of cells from damage due to oxygen radicals. We examined the interaction between ODC activity and intracellular glutathione concentrations in EL4 murine lymphoblastoid cells. The intracellular glutathione concentration could be augmented in EL4 cells when cultured with the cysteine delivery agents 2-oxothiazolidine 4-carboxylate (OTC) and 2-mercaptoethanol (2-ME) and suppressed with the gamma-glutamylcysteine synthetase inhibitor buthionine sulfoximine (BSO). OTC and 2-ME suppressed ODC activity in fresh serum and PMA-activated EL4 cells. BSO had no effect on ODC activity of EL4 cells cultured in the presence of PMA. While both OTC and 2-ME augmented the total intracellular glutathione concentration, PMA enhanced only the level of oxidized glutathione. To determine if the mechanism by which PMA or fresh serum altered intracellular glutathione and ODC activity was through the generation of oxygen radicals, EL4 cells were cultured with free radical scavengers. The nonpermeant electron acceptor potassium ferricyanide, and the H2O2 scavenger catalase, lowered ODC activity in both serum-stimulated and PMA-activated EL4 cells. Similarly, incubation of EL4 cells with either potassium ferricyanide or catalase elevated intracellular glutathione concentrations. These data suggest that (a) modulation of intracellular glutathione in the EL4 lymphoblastoid cell line alters ODC activity induced by fresh serum and by the mitogen PMA; (b) activation of EL4 cells by PMA alone alters intracellular glutathione metabolism, which may be associated with its role as a mitogen in lymphocyte activation; and (c) the generation of free radicals in EL4 cells may play a positive role in cellular activation. JF - Cellular immunology AU - Fidelus, R K AD - Veterans Administration Medical Center, Research Service, Philadelphia, Pennsylvania. Y1 - 1988/04/15/ PY - 1988 DA - 1988 Apr 15 SP - 175 EP - 182 VL - 113 IS - 1 SN - 0008-8749, 0008-8749 KW - Free Radicals KW - 0 KW - Thiazoles KW - Thiazolidines KW - Mercaptoethanol KW - 60-24-2 KW - Glutathione KW - GAN16C9B8O KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Oxygen KW - S88TT14065 KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - 2-oxothiazolidine-4-carboxylic acid KW - X7063P804E KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured KW - Glutathione -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Thymoma -- immunology KW - Mercaptoethanol -- pharmacology KW - Cell Line KW - Thymoma -- metabolism KW - Thymoma -- enzymology KW - Thiazoles -- pharmacology KW - Lymphocyte Activation -- drug effects KW - Oxygen -- physiology KW - Thiazoles -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78197865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=The+generation+of+oxygen+radicals%3A+a+positive+signal+for+lymphocyte+activation.&rft.au=Fidelus%2C+R+K&rft.aulast=Fidelus&rft.aufirst=R&rft.date=1988-04-15&rft.volume=113&rft.issue=1&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-14 N1 - Date created - 1988-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of the oxidation of the urinary bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine by pyrazole and 4-substituted pyrazoles. AN - 78169986; 3358795 JF - Biochemical pharmacology AU - Irving, C C AU - Daniel, D S AD - Veterans Administration Medical Center, Memphis, TN. Y1 - 1988/04/15/ PY - 1988 DA - 1988 Apr 15 SP - 1642 EP - 1644 VL - 37 IS - 8 SN - 0006-2952, 0006-2952 KW - Nitrosamines KW - 0 KW - Pyrazoles KW - NAD KW - 0U46U6E8UK KW - 4-bromopyrazole KW - 2075-45-8 KW - Butylhydroxybutylnitrosamine KW - 3817-11-6 KW - pyrazole KW - 3QD5KJZ7ZJ KW - fomepizole KW - 83LCM6L2BY KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - NAD -- metabolism KW - Animals KW - Oxidation-Reduction -- drug effects KW - In Vitro Techniques KW - Liver -- metabolism KW - Male KW - Urinary Bladder -- metabolism KW - Pyrazoles -- pharmacology KW - Nitrosamines -- metabolism KW - Butylhydroxybutylnitrosamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78169986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Inhibition+of+the+oxidation+of+the+urinary+bladder+carcinogen+N-butyl-N-%284-hydroxybutyl%29nitrosamine+by+pyrazole+and+4-substituted+pyrazoles.&rft.au=Irving%2C+C+C%3BDaniel%2C+D+S&rft.aulast=Irving&rft.aufirst=C&rft.date=1988-04-15&rft.volume=37&rft.issue=8&rft.spage=1642&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-17 N1 - Date created - 1988-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preattentive deficit in temporal processing by chronic schizophrenics. AN - 85249009; pmid-3370263 AB - Preattentive visual filtering by two types of neural cells (transient and sustained) constitutes the basic neural correlates underlying visual perception. Transient cells respond abruptly to temporal modulation and to the low spatial frequency components of visual stimuli. Their function is localization of objects and global perception (i.e., detection). Sustained cells respond slowly and selectively to high spatial frequencies and are believed to be responsible for the "oblique effect" (i.e., reduced responsiveness to obliquely oriented high spatial frequencies), which likely occurs at the striate cortex. Their function is to discern the details of an object (i.e., identification). The present study evaluated early visual processing in normal controls and schizophrenics by presenting vertical and oblique (45 degrees) spatial frequency gratings of 0.9 and 12 c/deg that were presented for 50, 100, 175, and 250-msec pulses. Threshold, in milliseconds, to detect an interstimulus interval (ISI) between two grating pulses was the dependent measure. Schizophrenics required longer ISIs for each grating duration, except for 250 msec, and longer ISIs for the 15 c/deg oblique grating. The results indicate that schizophrenics have a preattentive processing deficit that is further elaborated at the cortical level. JF - Biological Psychiatry AU - Schwartz, B D AU - Mallott, D B AU - Winstead, D K AD - Veterans Administration Medical Center, New Orleans, LA. PY - 1988 SP - 664 EP - 669 VL - 23 IS - 7 SN - 0006-3223, 0006-3223 KW - Human KW - Adult KW - Chronic Disease KW - Reaction Time KW - Orientation KW - Form Perception KW - Pattern Recognition, Visual KW - Schizophrenic Psychology KW - Attention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85249009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Preattentive+deficit+in+temporal+processing+by+chronic+schizophrenics.&rft.au=Schwartz%2C+B+D%3BMallott%2C+D+B%3BWinstead%2C+D+K&rft.aulast=Schwartz&rft.aufirst=B&rft.date=1988-04-01&rft.volume=23&rft.issue=7&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Squamous cell cancer of the liver arising from a solitary benign nonparasitic hepatic cyst. AN - 85213702; pmid-3279761 AB - A case of squamous cell carcinoma arising from a solitary benign nonparasitic hepatic cyst (SBNHC) causing bile duct obstruction is presented. A review of the literature regarding SBNHC suggests that, although these lesions may appear benign, they may also undergo metaplastic and subsequent malignant transformation. This appears to be particularly true when the SBNHC is lined with squamous epithelium. Once squamous cell carcinoma arises from one of these lesions, the prognosis is extremely grave, despite all forms of surgical and medical management. JF - The American Journal of Gastroenterology AU - Lynch, M J AU - McLeod, M K AU - Weatherbee, L AU - Gilsdorf, J R AU - Guice, K S AU - Eckhauser, F E AD - Department of Surgery, Veterans Administration Medical Center, Ann Arbor, Michigan. PY - 1988 SP - 426 EP - 431 VL - 83 IS - 4 SN - 0002-9270, 0002-9270 KW - Liver Neoplasms KW - Liver Diseases KW - Human KW - Middle Age KW - Case Report KW - Carcinoma, Squamous Cell KW - Cysts KW - Bile Duct Obstruction, Extrahepatic KW - Cell Transformation, Neoplastic KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Squamous+cell+cancer+of+the+liver+arising+from+a+solitary+benign+nonparasitic+hepatic+cyst.&rft.au=Lynch%2C+M+J%3BMcLeod%2C+M+K%3BWeatherbee%2C+L%3BGilsdorf%2C+J+R%3BGuice%2C+K+S%3BEckhauser%2C+F+E&rft.aulast=Lynch&rft.aufirst=M&rft.date=1988-04-01&rft.volume=83&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The development of endolymphatic hydrops following CMV inoculation of the endolymphatic sac. AN - 85188098; pmid-2832669 AB - The effect of inoculation of cytomegalovirus (CMV) into the endolymphatic sac was examined in CMV-seronegative and seropositive animals. Seronegative animals developed hearing loss, infection in the epithelial cells of the endolymphatic sac and perisaccular connective tissue, and endolymphatic hydrops. Control animals inoculated with inactivated CMV showed no hearing loss, viral infection, or endolymphatic hydrops. Seropositive animals showed complete protection from hearing loss and viral infection, yet a monocytic infiltrate was seen surrounding the endolymphatic sac. Associated with this localized immune response was mild evidence of endolymphatic hydrops in 40% (2/5) of the animals. Control seropositive animals inoculated with inactivated CMV showed no hearing loss or morphological changes. CMV then, can infect cells of the endolymphatic sac resulting in hearing loss and endolymphatic hydrops. The immune response to CMV in seropositive animals is protective, but is associated with endolymphatic sac inflammation. JF - The Laryngoscope AU - Fukuda, S AU - Keithley, E M AU - Harris, J P AD - Research Service, Veterans Administration Medical Center, San Diego, CA. PY - 1988 SP - 439 EP - 443 VL - 98 IS - 4 SN - 0023-852X, 0023-852X KW - Cochlea KW - Meniere's Disease KW - Support, U.S. Gov't, P.H.S. KW - Guinea Pigs KW - Endolymphatic Sac KW - Animal KW - Antigens, Viral KW - Cytomegalovirus Infections KW - Support, U.S. Gov't, Non-P.H.S. KW - Cytomegalovirus KW - Temporal Bone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85188098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=The+development+of+endolymphatic+hydrops+following+CMV+inoculation+of+the+endolymphatic+sac.&rft.au=Fukuda%2C+S%3BKeithley%2C+E+M%3BHarris%2C+J+P&rft.aulast=Fukuda&rft.aufirst=S&rft.date=1988-04-01&rft.volume=98&rft.issue=4&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A method of rapid-sequence induction using high-dose narcotics with vecuronium or vecuronium and pancuronium in patients with coronary artery disease. AN - 78813872; 17171909 AB - A method of rapid-sequence induction was studied in 18 patients undergoing coronary artery bypass grafting (CABG) to assess the adequacy of relaxation for endotracheal intubation without resulting in major changes in heart rate (HR). Ten patients received vercuronium, 0.2 mg/kg (V); and eight patients received vecuronium, 0.1 mg/kg, and pancuronium, 0.1 mg/kg (V + P). All patients then received fentanyl, 50 to 70 microg/kg, or sufentanil, 5 to 7 microg/kg, followed 60 seconds later by intubation. Patients were assessed for ulnar and mandibular nerve response to train-of-four (TOF) and tetanic (T) stimulation at 60 seconds; presence or absence of coughing or bucking; degree of vocal cord relaxation (1=none, 2=some, 3=complete relaxation); ability to intubate at 60 seconds; and changes in HR. At the time of intubation, 17 patients had four twitches to TOF and a positive response to T stimulation of the ulnar nerve, while all 18 patients had zero or one twitch to TOF and only four had a positive response to T stimulation of the mandibular nerve (P < .0001 for T and TOF, ulnar v mandibular). Coughing and bucking were not observed in any patient. Vocal cord position was "3" in 14 patients and "2" in four patients. All patients were intubated without difficulty. The mean change in HR was -4.1 beats/min for patients receiving V and +16.4 beats/min for those receiving V + P (P < .002 for change in HR), with two V + P patients developing tachycardia. It is concluded that the onset of neuromuscular blockade is more rapid in the distribution of the mandibular nerve than at the ulnar nerve; mandibular nerve stimulation is a better predictor of adequate intubating conditions; good intubating conditions can be attained with either V or V + P; and, rapid-sequence induction with V is safe from a cardiac standpoint as measured by changes in HR, but the addition of pancuronium is unnecessary. JF - Journal of cardiothoracic anesthesia AU - Nakatsuka, M AU - Franks, P AU - Keenan, R L AD - Department of Anesthesiology, Medical College of Virginia, and McGuire Veterans Administration Medical Center, Richmond, USA. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 177 EP - 181 VL - 2 IS - 2 SN - 0888-6296, 0888-6296 KW - Anesthetics, Combined KW - 0 KW - Narcotics KW - Neuromuscular Nondepolarizing Agents KW - Vecuronium Bromide KW - 7E4PHP5N1D KW - Sufentanil KW - AFE2YW0IIZ KW - Pancuronium KW - J76UF062FS KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Intubation, Intratracheal -- methods KW - Muscle Relaxation -- drug effects KW - Mandibular Nerve -- drug effects KW - Fentanyl -- administration & dosage KW - Heart Rate -- drug effects KW - Middle Aged KW - Sufentanil -- administration & dosage KW - Vocal Cords -- drug effects KW - Ulnar Nerve -- drug effects KW - Time Factors KW - Coronary Artery Bypass -- methods KW - Female KW - Male KW - Pancuronium -- adverse effects KW - Anesthetics, Combined -- administration & dosage KW - Vecuronium Bromide -- administration & dosage KW - Coronary Artery Disease -- surgery KW - Narcotics -- administration & dosage KW - Anesthetics, Combined -- adverse effects KW - Neuromuscular Nondepolarizing Agents -- administration & dosage KW - Vecuronium Bromide -- adverse effects KW - Pancuronium -- administration & dosage KW - Neuromuscular Nondepolarizing Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78813872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiothoracic+anesthesia&rft.atitle=A+method+of+rapid-sequence+induction+using+high-dose+narcotics+with+vecuronium+or+vecuronium+and+pancuronium+in+patients+with+coronary+artery+disease.&rft.au=Nakatsuka%2C+M%3BFranks%2C+P%3BKeenan%2C+R+L&rft.aulast=Nakatsuka&rft.aufirst=M&rft.date=1988-04-01&rft.volume=2&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiothoracic+anesthesia&rft.issn=08886296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Testing for human immunodeficiency virus in substance abuse treatment. AN - 78415097; 3166488 JF - Journal of psychoactive drugs AU - Clark, H W AU - Washburn, P AD - Alcohol Inpatient Unit, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1988 SP - 203 EP - 211 VL - 20 IS - 2 SN - 0279-1072, 0279-1072 KW - Antibodies, Viral KW - 0 KW - HIV Antibodies KW - Index Medicus KW - AIDS/HIV KW - United States KW - California KW - San Francisco KW - Patient Education as Topic KW - Humans KW - HIV Seropositivity -- diagnosis KW - Adult KW - Ethics, Medical KW - Male KW - Legislation, Medical KW - Antibodies, Viral -- analysis KW - Acquired Immunodeficiency Syndrome -- transmission KW - Acquired Immunodeficiency Syndrome -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Acquired Immunodeficiency Syndrome -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78415097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Testing+for+human+immunodeficiency+virus+in+substance+abuse+treatment.&rft.au=Clark%2C+H+W%3BWashburn%2C+P&rft.aulast=Clark&rft.aufirst=H&rft.date=1988-04-01&rft.volume=20&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-24 N1 - Date created - 1988-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - L-2-oxothiazolidine-4-carboxylate protects cultured endothelial cells against hyperoxia-induced injury. AN - 78310328; 3270344 AB - When bovine pulmonary artery endothelial monolayers were exposed to hyperoxia (95% O2 and 5% Co2), they responded by selectively elevating the intracellular concentration of glutathione without affecting the activities of glutathione peroxidase or glutathione reductase, L-2-Oxothiazolidine-4-carboxylate, an intracellular cysteine-delivering agent, further enhanced the intracellular concentration of glutathione in oxygen-exposed endothelial cells and protected them from the lethal effect of hyperoxia. In contrast, buthionine sulfoximine, a potent inhibitor of gamma-glutamylcysteine synthetase, reduced the glutathione concentration and rendered the cells more sensitive to the toxic effect of oxygen. Both L-2-oxothiazolidine-4-carboxylate and buthionine sulfoximine had no effect on the activities of glutathione peroxidase or glutathione reductase. Our results suggest that L-2-oxothiazolidine-4-carboxylate may have the potential of preventing oxygen toxicity. JF - Inflammation AU - Tsan, M F AU - Phillips, P G AD - Veterans Administration Medical Center, Albany, New York. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 113 EP - 121 VL - 12 IS - 2 SN - 0360-3997, 0360-3997 KW - Thiazoles KW - 0 KW - Thiazolidines KW - Glutathione KW - GAN16C9B8O KW - Oxygen KW - S88TT14065 KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - 2-oxothiazolidine-4-carboxylic acid KW - X7063P804E KW - Index Medicus KW - Space life sciences KW - Cells, Cultured KW - Thiazoles -- pharmacology KW - Endothelium, Vascular -- drug effects KW - Oxygen -- toxicity KW - Glutathione -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78310328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inflammation&rft.atitle=L-2-oxothiazolidine-4-carboxylate+protects+cultured+endothelial+cells+against+hyperoxia-induced+injury.&rft.au=Tsan%2C+M+F%3BPhillips%2C+P+G&rft.aulast=Tsan&rft.aufirst=M&rft.date=1988-04-01&rft.volume=12&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Inflammation&rft.issn=03603997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-19 N1 - Date created - 1988-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aminoglycoside nephrotoxicity. AN - 78295572; 3290565 JF - Kidney international AU - Humes, H D AD - Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 900 EP - 911 VL - 33 IS - 4 SN - 0085-2538, 0085-2538 KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Index Medicus KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Aged KW - Male KW - Anti-Bacterial Agents -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78295572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Aminoglycoside+nephrotoxicity.&rft.au=Humes%2C+H+D&rft.aulast=Humes&rft.aufirst=H&rft.date=1988-04-01&rft.volume=33&rft.issue=4&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-29 N1 - Date created - 1988-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validity of self-report in alcoholism research: results of a Veterans Administration Cooperative Study. AN - 78244690; 3287982 AB - The validity of self-report in alcoholism treatment research is controversial. Our recently completed Veterans Administration Cooperative Study evaluating the efficacy of disulfiram treatment for alcoholism provided an opportunity to assess the validity of self-report. To assess treatment response, patients and household contacts were interviewed at seven scheduled points during the 1 year of follow-up. Blood specimens also were obtained from the patients at these times and were analyzed for ethanol. Eighty-eight percent of the patient and/or collateral interviews were obtained at 6 months and 90% at 1 year. The mean number of blood and urine specimens collected per patient was 4.3 and 14.4, respectively. Outcome criteria included continuous abstinence during the year and total number of drinking days. Continuous abstinence: If we had had only the patients' self reports, we would have significantly underestimated the percentage of men who drank. By self-report 58.7% (355/605) relapsed whereas the combination of self report, collaterals' reports, and laboratory tests indicated that 72.4% (438/605) drank (p less than 0.001). Using Bayes' theorem, the conditional probability that a patient is continuously abstinent for 1 year when he so claims is 65%. Total drinking days: Of the 213 patient-collateral pairs each of whom provided all seven scheduled interviews, 46.9% (100/213) agreed on the total number of drinking days during the year.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Fuller, R K AU - Lee, K K AU - Gordis, E AD - Veterans Administration Medical Center, Cleveland, OH 44106. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 201 EP - 205 VL - 12 IS - 2 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Ethanol -- blood KW - Ethanol -- urine KW - Humans KW - Surveys and Questionnaires KW - Sexual Abstinence KW - Alcohol Drinking KW - Research Design KW - Male KW - Alcoholism -- diagnosis KW - Alcoholism -- urine KW - Self-Assessment KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78244690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Validity+of+self-report+in+alcoholism+research%3A+results+of+a+Veterans+Administration+Cooperative+Study.&rft.au=Fuller%2C+R+K%3BLee%2C+K+K%3BGordis%2C+E&rft.aulast=Fuller&rft.aufirst=R&rft.date=1988-04-01&rft.volume=12&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-11 N1 - Date created - 1988-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurobehavioral toxicity and tolerance to the herbicide 2,4-dichlorophenoxyacetic acid-n-butyl ester (2,4-D ester). AN - 78228542; 3371581 AB - 2,4-Dichlorophenoxyacetic acid (2,4-D) is a commonly used herbicide and one component of Agent Orange. The subchronic neurobehavioral toxicity of 2,4-D-n-butyl ester (2,4-D ester) was assessed in rats by monitoring performance in a battery of behavioral tests. 2,4-D ester was injected daily (150-250 mg/kg sc) in four successive 14-day periods. Five- to eight-day exposure-free periods separated dosing escalations. All doses produced a significant decrease in schedule-controlled lever pressing and photocell locomotor activity while increasing landing foot splay. Peak effects occurred by the 3rd injection, while tolerance developed by the 10th injection. Neurobehavioral effects associated with 2,4-D ester exposure were rapidly reversible and disappeared within 24-48 hr. Brain and blood 2,4-D kinetics revealed that the compound accumulated in brain with repeated dosing. This observation indicates a cellular mechanism for tolerance development. Other neurobehavioral measures, rota rod and grip strength, were not consistently affected by 2,4-D ester. These studies confirm that 2,4-D ester produces behavioral toxicity, that tolerance develops to the 2,4-D ester-induced behavioral deficits with repeated exposures, and that a cellular mechanism appears to be responsible for the developed tolerance to 2,4-D ester. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Schulze, G E AU - Dougherty, J A AD - Veterans Administration Medical Center, Lexington, Kentucky 40511. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 413 EP - 424 VL - 10 IS - 3 SN - 0272-0590, 0272-0590 KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Conditioning, Operant -- drug effects KW - Drug Tolerance KW - Animals KW - Psychomotor Performance -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Nervous System Diseases -- physiopathology KW - Nervous System Diseases -- chemically induced KW - 2,4-Dichlorophenoxyacetic Acid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78228542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Neurobehavioral+toxicity+and+tolerance+to+the+herbicide+2%2C4-dichlorophenoxyacetic+acid-n-butyl+ester+%282%2C4-D+ester%29.&rft.au=Schulze%2C+G+E%3BDougherty%2C+J+A&rft.aulast=Schulze&rft.aufirst=G&rft.date=1988-04-01&rft.volume=10&rft.issue=3&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-14 N1 - Date created - 1988-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antipsychotics: how strict the formulary? AN - 78225071; 2897277 AB - Seventeen antipsychotic medications are available in the U.S. Antipsychotic formulary considerations include relative efficacy, individual patient response, relative differences in adverse effects, dosage form availability, blood level monitoring, and generic availability. Chlorpromazine, thioridazine, haloperidol, and fluphenazine are recommended for formulary inclusion based on research and clinical considerations. A recommendation for managing a patient receiving a nonformulary antipsychotic is presented. JF - Drug intelligence & clinical pharmacy AU - Alexander, B AD - Department of Pharmacy, Veterans Administration Medical Center, Iowa City, IA. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 324 EP - 326 VL - 22 IS - 4 SN - 0012-6578, 0012-6578 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Antipsychotic Agents -- administration & dosage KW - Formularies as Topic KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78225071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+intelligence+%26+clinical+pharmacy&rft.atitle=Antipsychotics%3A+how+strict+the+formulary%3F&rft.au=Alexander%2C+B&rft.aulast=Alexander&rft.aufirst=B&rft.date=1988-04-01&rft.volume=22&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Drug+intelligence+%26+clinical+pharmacy&rft.issn=00126578&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-30 N1 - Date created - 1988-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human amnesia and animal models of amnesia: performance of amnesic patients on tests designed for the monkey. AN - 78200727; 3130073 AB - The performance of amnesic patients was assessed on five tasks, which have figured prominently in the development of animal models of human amnesia in the monkey. The amnesic patients were impaired on four of these tasks (delayed nonmatching to sample, object-reward association, 8-pair concurrent discrimination learning, and an object discrimination task), in correspondence with previous findings for monkeys with bilateral medial temporal or diencephalic lesions. Moreover, performance of the amnesic patients correlated with the ability to verbalize the principle underlying the tasks and with the ability to describe and recognize the stimulus materials. These tasks therefore seem to be sensitive to the memory functions that are affected in human amnesia, and they can provide valid measures of memory impairment in studies with monkeys. For the fifth task (24-hour concurrent discrimination learning), the findings for the amnesic patients did not correspond to previous findings for operated monkeys. Whereas monkeys with medial temporal lesions reportedly learn this task at a normal rate, the amnesic patients were markedly impaired. Monkeys may learn this task differently than humans. JF - Behavioral neuroscience AU - Squire, L R AU - Zola-Morgan, S AU - Chen, K S AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 210 EP - 221 VL - 102 IS - 2 SN - 0735-7044, 0735-7044 KW - Index Medicus KW - Verbal Learning KW - Animals KW - Discrimination Learning KW - Reward KW - Humans KW - Middle Aged KW - Attention KW - Male KW - Haplorhini KW - Female KW - Learning Disorders -- physiopathology KW - Memory Disorders -- physiopathology KW - Amnesia -- physiopathology KW - Alcohol Amnestic Disorder -- physiopathology KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78200727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Human+amnesia+and+animal+models+of+amnesia%3A+performance+of+amnesic+patients+on+tests+designed+for+the+monkey.&rft.au=Squire%2C+L+R%3BZola-Morgan%2C+S%3BChen%2C+K+S&rft.aulast=Squire&rft.aufirst=L&rft.date=1988-04-01&rft.volume=102&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-16 N1 - Date created - 1988-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Simultaneous chemotherapy and radiotherapy for squamous cell lung cancer. AN - 78174846; 3282422 AB - Simultaneous chemotherapy and radiotherapy was evaluated in 13 patients with inoperable, limited stage squamous cell lung cancer. The chemotherapeutic agents bleomycin, methotrexate, 5-fluorouracil, vinblastine, and cisplatin were administered on days 1 and 5 of two treatment cycles given 5 weeks apart. Radiation therapy was given in three 2-week cycles, the first two starting on the second day of each chemotherapy cycle and the third starting 3 weeks after the second course of radiation. The total dose was 5000-5500 rad (50-55 Gy) in 180 rad fractions. The objective response rate (complete response + partial response) was 85%, with 38% complete responders. Median survival was 7 months with two patients surviving 34 months, one with disease and one disease-free. Treatment toxicity was predominantly hematopoietic and renal. Two patients died with massive pulmonary hemorrhage while receiving treatment and a third patient died of acute respiratory failure 1 month after completing therapy. The severe toxicity and the failure to obtain long duration tumor control makes this regimen unsuitable for future use. JF - American journal of clinical oncology AU - Wadleigh, R G AU - Lunzer, S AU - Krasnow, S H AU - Hussain, M A AU - Johnston-Anderson, A AU - White, K S AU - Cohen, M H AD - Medical Oncology Section, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 122 EP - 125 VL - 11 IS - 2 SN - 0277-3732, 0277-3732 KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Prognosis KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Male KW - Lung Neoplasms -- radiotherapy KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78174846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=Simultaneous+chemotherapy+and+radiotherapy+for+squamous+cell+lung+cancer.&rft.au=Wadleigh%2C+R+G%3BLunzer%2C+S%3BKrasnow%2C+S+H%3BHussain%2C+M+A%3BJohnston-Anderson%2C+A%3BWhite%2C+K+S%3BCohen%2C+M+H&rft.aulast=Wadleigh&rft.aufirst=R&rft.date=1988-04-01&rft.volume=11&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-20 N1 - Date created - 1988-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of two intravenous cyclosporine infusion schedules in marrow transplant recipients. AN - 78172848; 3282363 JF - Transplantation AU - Tallman, M S AU - Nemunaitis, J J AU - McGuire, T R AU - Yee, G C AU - Hughes, T E AU - Almgren, J D AU - Appelbaum, F R AU - Higano, C S AU - McGuffin, R W AU - Singer, J W AD - Veterans Administration Medical Center, Seattle, WA 98108. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 810 EP - 813 VL - 45 IS - 4 SN - 0041-1337, 0041-1337 KW - Cyclosporins KW - 0 KW - Index Medicus KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Humans KW - Adult KW - Leukemia, Myeloid -- therapy KW - Middle Aged KW - Leukemia, Myeloid -- physiopathology KW - Cyclosporins -- adverse effects KW - Cyclosporins -- therapeutic use KW - Kidney -- drug effects KW - Graft vs Host Disease -- prevention & control KW - Cyclosporins -- administration & dosage KW - Kidney -- physiopathology KW - Bone Marrow Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78172848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Comparison+of+two+intravenous+cyclosporine+infusion+schedules+in+marrow+transplant+recipients.&rft.au=Tallman%2C+M+S%3BNemunaitis%2C+J+J%3BMcGuire%2C+T+R%3BYee%2C+G+C%3BHughes%2C+T+E%3BAlmgren%2C+J+D%3BAppelbaum%2C+F+R%3BHigano%2C+C+S%3BMcGuffin%2C+R+W%3BSinger%2C+J+W&rft.aulast=Tallman&rft.aufirst=M&rft.date=1988-04-01&rft.volume=45&rft.issue=4&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-26 N1 - Date created - 1988-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alprazolam as an antidepressant. AN - 78168144; 3281931 AB - Alprazolam appears to be an effective antidepressant in the treatment of outpatients who have a diagnosis of major depressive disorder. The authors have reviewed six controlled double-blind studies of alprazolam in the treatment of depression. Four of the six studies included only outpatients and clearly demonstrated a clinical effectiveness comparable to that of the tricyclics but with fewer, less severe side effects and better tolerance. The other two studies involved both inpatients and outpatients, so no conclusions can be drawn regarding the effectiveness of alprazolam in an inpatient population; further controlled studies are needed to answer this question. No satisfactory explanation exists for the mechanism of alprazolam's proposed antidepressant action. JF - The Journal of clinical psychiatry AU - Warner, M D AU - Peabody, C A AU - Whiteford, H A AU - Hollister, L E AD - Veterans Administration Medical Center, Palo Alto, Calif. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 148 EP - 150 VL - 49 IS - 4 SN - 0160-6689, 0160-6689 KW - Antidepressive Agents, Tricyclic KW - 0 KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Hospitalization KW - Double-Blind Method KW - Humans KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Clinical Trials as Topic KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Ambulatory Care KW - Alprazolam -- therapeutic use KW - Depressive Disorder -- psychology KW - Depressive Disorder -- drug therapy KW - Alprazolam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78168144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Alprazolam+as+an+antidepressant.&rft.au=Warner%2C+M+D%3BPeabody%2C+C+A%3BWhiteford%2C+H+A%3BHollister%2C+L+E&rft.aulast=Warner&rft.aufirst=M&rft.date=1988-04-01&rft.volume=49&rft.issue=4&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-13 N1 - Date created - 1988-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells. AN - 78166325; 3128345 AB - We studied the effect of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma), alone and in combination, on the expression of chemotactic peptide receptors, stimulus-induced actin polymerization, hydrogen peroxide production (H2O2), and expression of nonspecific esterase (NSE) positivity in human promyelocytic leukemic cell line HL-60. These parameters were analyzed following a five-day culture with the cytokines. Chemotactic peptide receptor expression was studied using the fluoresceinated hexapeptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine and flow cytometry. Actin polymerization, an important event required for chemotaxis and phagocytosis, was studied using NBD-phallacidin labeling, following stimulation with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA). TNF increased the expression of chemotactic peptide receptors in a dose-dependent fashion, and there was good correlation between the receptor expression, stimulus-induced actin polymerization, H2O2 production, and NSE positivity. IFN-gamma was less potent in inducing all the parameters studied but exerted a positive cooperative effect when combined with TNF. IFN-gamma at high concentrations induced chemotactic peptide receptors comparable in magnitude to that seen with TNF but failed to prime these cells to undergo actin polymerization in response to FMLP or PMA. Undifferentiated HL-60 cells showed a decrease in F-actin content on stimulation with PMA. This suggests that protein kinase C might have a negative regulatory role in stimulus-induced actin polymerization. The observations reported here indicate that appropriate combinations of different inducing agents with different modes of action might be necessary to duplicate the functional abilities of mature phagocytic cells. JF - Blood AU - Rao, K M AU - Misukonis, M A AU - Cohen, H J AU - Weinberg, J B AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Durham, NC 27705. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 1062 EP - 1067 VL - 71 IS - 4 SN - 0006-4971, 0006-4971 KW - Actins KW - 0 KW - Amanitins KW - Fluorescent Dyes KW - Free Radicals KW - Oligopeptides KW - Receptors, Formyl Peptide KW - Receptors, Immunologic KW - Tumor Necrosis Factor-alpha KW - 7-nitrobenz-2-oxa-1,3-diazole-phallacidin KW - 73413-78-2 KW - Interferon-gamma KW - 82115-62-6 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Monocytes -- cytology KW - Hydrogen Peroxide -- metabolism KW - Humans KW - Monocytes -- analysis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Drug Synergism KW - Cell Differentiation -- drug effects KW - Cell Line KW - Receptors, Immunologic -- drug effects KW - Receptors, Immunologic -- metabolism KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Oligopeptides -- metabolism KW - Interferon-gamma -- pharmacology KW - Actins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78166325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Cooperative+effect+of+tumor+necrosis+factor+and+gamma-interferon+on+chemotactic+peptide+receptor+expression+and+stimulus-induced+actin+polymerization+in+HL-60+cells.&rft.au=Rao%2C+K+M%3BMisukonis%2C+M+A%3BCohen%2C+H+J%3BWeinberg%2C+J+B&rft.aulast=Rao&rft.aufirst=K&rft.date=1988-04-01&rft.volume=71&rft.issue=4&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-17 N1 - Date created - 1988-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk factors for drug-induced parkinsonism in tardive dyskinesia patients. AN - 78163981; 2895762 AB - Using multivariate statistical analyses, the authors identified risk factors for development of drug-induced parkinsonism (DIP) in 66 tardive dyskinesia (TD) patients. Older age, recent use of neuroleptics, shorter duration of past neuroleptic exposure, and severity of TD were associated with increased risk of DIP. The clinician should devise treatment strategies in anticipation of the occurrence of DIP regardless of the presence or absence of TD, especially in older patients. New models for the pathophysiology of the two disorders are needed. JF - The Journal of clinical psychiatry AU - Hansen, T E AU - Brown, W L AU - Weigel, R M AU - Casey, D E AD - Portland Veterans Administration Medical Center, OR 97207. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 139 EP - 141 VL - 49 IS - 4 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Age Factors KW - Humans KW - Neurologic Examination KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Cross-Sectional Studies KW - Hospitalization KW - Risk Factors KW - Adult KW - Basal Ganglia -- physiopathology KW - Middle Aged KW - Female KW - Male KW - Basal Ganglia -- metabolism KW - Parkinson Disease, Secondary -- physiopathology KW - Parkinson Disease, Secondary -- chemically induced KW - Dyskinesia, Drug-Induced -- complications KW - Dyskinesia, Drug-Induced -- etiology KW - Parkinson Disease, Secondary -- complications KW - Dyskinesia, Drug-Induced -- physiopathology KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78163981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Risk+factors+for+drug-induced+parkinsonism+in+tardive+dyskinesia+patients.&rft.au=Hansen%2C+T+E%3BBrown%2C+W+L%3BWeigel%2C+R+M%3BCasey%2C+D+E&rft.aulast=Hansen&rft.aufirst=T&rft.date=1988-04-01&rft.volume=49&rft.issue=4&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-13 N1 - Date created - 1988-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective effects of analogs of luteinizing hormone-releasing hormone against chemotherapy-induced testicular damage in rats. AN - 78160160; 2965391 AB - Possible protective effects of analogs of luteinizing hormone-releasing hormone (LH-RH) against testicular damage caused by various cytotoxic agents were investigated in rats. The agonist [D-Trp6]LH-RH (in which Gly-6 is replaced by D-tryptophan) and the antagonist N-Ac-[D-Phe(pCl)1,2,D-Trp3,D-Arg6,D-Ala10]LH-RH were administered for 12 weeks: [D-Trp6]LH-RH was given once a month in the form of long-acting microcapsules liberating 25 micrograms of agonist per day, and the antagonist was injected s.c. at a dose of 1000 micrograms per kg of body weight per day for the first 3 weeks and, thereafter, at a dose of 500 micrograms per kg of body weight per day. After a recovery period of 3 months, most seminiferous tubules in the antagonist-treated group showed a normal morphology, while patches of tubules in the agonist-treated group continued to show some suppression of spermatogenesis. Administration of busulfan, cisplatin, or cyclophosphamide produced only a reversible testicular injury, and pretreatment with LH-RH analogs seemed to temporarily enhance the tubular damage. Administration of procarbazine (200 mg per kg of body weight per week for 6 weeks) resulted in decreased testicular weights and increased serum LH levels 1 and 3 months after the discontinuation of treatment. The histology showed severe diffuse damage to seminiferous tubules. The germinal cells completely disappeared and the Sertoli cells were markedly degenerated. This damage was not restored even after a recovery period of 5 months. Some animals were pretreated for 6 weeks with the agonist or antagonist and then received procarbazine for 6 weeks while administration of analogs was continued. In these animals, the decrease in testicular weights and increase in serum LH levels after procarbazine were less marked than in the group not pretreated with the analogs. Three and 5 months after cessation of treatment, a large number of tubules showed a complete restoration of structural morphology in 30-45% of the animals that received procarbazine and the LH-RH agonist or antagonist. These results indicate that pretreatment with LH-RH analogs may protect testes against damage caused by some cytotoxic agents. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Karashima, T AU - Zalatnai, A AU - Schally, A V AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 2329 EP - 2333 VL - 85 IS - 7 SN - 0027-8424, 0027-8424 KW - Antineoplastic Agents KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Procarbazine KW - 35S93Y190K KW - Triptorelin Pamoate KW - 57773-63-4 KW - LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)- KW - 83539-08-6 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Procarbazine -- toxicity KW - Procarbazine -- antagonists & inhibitors KW - Spermatogenesis -- drug effects KW - Organ Size KW - Male KW - Testis -- drug effects KW - Testis -- pathology KW - Gonadotropin-Releasing Hormone -- antagonists & inhibitors KW - Antineoplastic Agents -- toxicity KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Antineoplastic Agents -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78160160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Protective+effects+of+analogs+of+luteinizing+hormone-releasing+hormone+against+chemotherapy-induced+testicular+damage+in+rats.&rft.au=Karashima%2C+T%3BZalatnai%2C+A%3BSchally%2C+A+V&rft.aulast=Karashima&rft.aufirst=T&rft.date=1988-04-01&rft.volume=85&rft.issue=7&rft.spage=2329&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-12 N1 - Date created - 1988-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Endocrinol (Copenh). 1979 Aug;91(4):601-8 [386680] Cancer Chemother Pharmacol. 1987;19(2):159-62 [3105906] Endocrinology. 1981 May;108(5):1998-2001 [7215310] Endocrinology. 1981 May;108(5):2019-21 [6783399] Lancet. 1981 May 23;1(8230):1132-4 [6112490] N Engl J Med. 1981 Sep 17;305(12):663-7 [6267464] Annu Rev Med. 1983;34:491-500 [6344774] J Androl. 1983 Jul-Aug;4(4):283-91 [6225758] Arch Androl. 1983 Oct;11(2):141-50 [6639202] Proc Soc Exp Biol Med. 1984 Mar;175(3):259-81 [6141569] Proc Natl Acad Sci U S A. 1984 Sep;81(18):5845-8 [6237365] Endocrinology. 1979 Nov;105(5):1191-201 [385303] Fertil Steril. 1984 Dec;42(6):906-14 [6389185] Br Med J (Clin Res Ed). 1985 Apr 13;290(6475):1096-7 [3921121] Proc Natl Acad Sci U S A. 1985 May;82(9):2975-9 [3157995] J Urol. 1985 Jul;134(1):187-90 [3925164] Cancer Res. 1985 Aug;45(8):3651-6 [3926307] Cancer Res. 1986 Apr;46(4 Pt 2):1909-14 [3081260] Endocr Rev. 1986 Feb;7(1):106-14 [3007079] Endocr Rev. 1986 Feb;7(1):115-24 [2420579] Endocr Rev. 1986 Feb;7(1):44-66 [2420580] Fertil Steril. 1986 Apr;45(4):443-59 [3082680] Int J Fertil. 1986 Sep-Oct;31(4):284-92 [2878898] Cancer Res. 1987 Feb 15;47(4):1093-7 [3542201] Proc Natl Acad Sci U S A. 1987 Feb;84(3):851-5 [2949328] Ann Intern Med. 1980 Jul;93(1):109-14 [6994532] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Familial double testicular tumors: identical chromosome changes in seminoma and embryonal carcinoma of the same testis. AN - 78156065; 3352038 AB - An identical abnormal chromosome, i(12p), and a marker chromosome of unknown origin were seen in 2 tumors of different histology (seminoma and embryonal carcinoma) in the same testis. A younger brother of the patient also had undergone orchiectomy for 2 seminomas in the left testis 2 years previously. These findings are discussed in relation to the possible cellular background of testicular tumors and their genetic parameters. JF - The Journal of urology AU - Haddad, F S AU - Sorini, P M AU - Somsin, A A AU - Nathan, M H AU - Dobbs, R M AU - Berger, C S AU - Sandberg, A A AD - Veterans Administration Hospital, Phoenix, Arizona. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 748 EP - 750 VL - 139 IS - 4 SN - 0022-5347, 0022-5347 KW - Abridged Index Medicus KW - Index Medicus KW - Karyotyping KW - Chromosome Banding KW - Humans KW - Testis -- pathology KW - Adult KW - Male KW - Dysgerminoma -- pathology KW - Teratoma -- genetics KW - Neoplasms, Multiple Primary -- pathology KW - Teratoma -- pathology KW - Testicular Neoplasms -- pathology KW - Dysgerminoma -- genetics KW - Chromosome Aberrations KW - Neoplasms, Multiple Primary -- genetics KW - Testicular Neoplasms -- genetics KW - Chromosomes, Human, Pair 12 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78156065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Familial+double+testicular+tumors%3A+identical+chromosome+changes+in+seminoma+and+embryonal+carcinoma+of+the+same+testis.&rft.au=Haddad%2C+F+S%3BSorini%2C+P+M%3BSomsin%2C+A+A%3BNathan%2C+M+H%3BDobbs%2C+R+M%3BBerger%2C+C+S%3BSandberg%2C+A+A&rft.aulast=Haddad&rft.aufirst=F&rft.date=1988-04-01&rft.volume=139&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-29 N1 - Date created - 1988-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - High cathepsin B activity in alveolar macrophages occurs with elastase-induced emphysema but not with bleomycin-induced pulmonary fibrosis in hamsters. AN - 78155071; 2451429 AB - Cathepsin B activity was quantitated in alveolar macrophages obtained from hamsters 10, 21, and 105 days after the intratracheal instillation of porcine pancreatic elastase, bleomycin, or normal saline. Alveolar macrophages lavaged from animals receiving elastase contained significantly higher enzyme levels at 21 and 105 days (16,200 and 17,000 U/mg protein/hr, respectively) as compared with saline-treated animals (12,300 units). In contrast, cells from animals receiving bleomycin showed a decrease in activity at 21 and 105 days (9700 and 9900 units, respectively). At 10 days enzyme levels did not differ significantly. The results suggest that cathepsin B levels in alveolar macrophages reflect differences in lung destruction and connective tissue repair in vivo. In addition, the finding of high cathepsin B activity in animals with emphysema suggests the possibility that cysteine proteases contribute to progressive lung destruction initiated by the intratracheal instillation of elastase. JF - The American journal of pathology AU - Padilla, M L AU - Galicki, N I AU - Kleinerman, J AU - Orlowski, M AU - Lesser, M AD - Pulmonary Division, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 92 EP - 101 VL - 131 IS - 1 SN - 0002-9440, 0002-9440 KW - Bleomycin KW - 11056-06-7 KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Cathepsin B KW - EC 3.4.22.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Reference Values KW - Mesocricetus KW - Lung -- pathology KW - Male KW - Cricetinae KW - Macrophages -- enzymology KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- enzymology KW - Cathepsin B -- metabolism KW - Emphysema -- enzymology KW - Emphysema -- pathology KW - Emphysema -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78155071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=High+cathepsin+B+activity+in+alveolar+macrophages+occurs+with+elastase-induced+emphysema+but+not+with+bleomycin-induced+pulmonary+fibrosis+in+hamsters.&rft.au=Padilla%2C+M+L%3BGalicki%2C+N+I%3BKleinerman%2C+J%3BOrlowski%2C+M%3BLesser%2C+M&rft.aulast=Padilla&rft.aufirst=M&rft.date=1988-04-01&rft.volume=131&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-12 N1 - Date created - 1988-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1969 Apr;41(1):345-54 [5775793] Cancer. 1958 Mar-Apr;11(2):283-91 [13511347] J Cell Biol. 1974 Nov;63(2 Pt 1):430-40 [4607946] Lab Invest. 1976 Apr;34(4):372-80 [177809] Biochem J. 1976 Feb 1;153(2):199-209 [6003] Am Rev Respir Dis. 1977 Jul;116(1):49-56 [879599] J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):721-9 [908690] Am Rev Respir Dis. 1978 Feb;117(2):299-305 [76454] Am Rev Respir Dis. 1978 Jun;117(6):1099-108 [78675] J Clin Invest. 1979 Sep;64(3):824-33 [89120] Am Rev Respir Dis. 1979 Sep;120(3):577-87 [90469] Lab Invest. 1979 Nov;41(5):379-84 [388072] Histochemistry. 1979;64(3):319-22 [521318] Life Sci. 1979 Nov 26;25(22):1885-91 [529991] J Lab Clin Med. 1980 Dec;96(6):943-53 [6159434] J Exp Med. 1980 Nov 1;152(5):1340-57 [7000966] Ciba Found Symp. 1979;(75):87-103 [233355] J Lab Clin Med. 1981 Apr;97(4):467-76 [7009773] Anat Rec. 1981 Nov;201(3):523-35 [6914132] Am Rev Respir Dis. 1982 Jan;125(1):85-8 [6175261] J Clin Invest. 1982 Apr;69(4):920-31 [6176595] Methods Enzymol. 1981;80 Pt C:535-61 [7043200] Acta Biol Med Ger. 1981;40(10-11):1625-36 [7342607] Am Rev Respir Dis. 1982 Jul;126(1):174-5 [6920251] Am Rev Respir Dis. 1982 Nov;126(5):914-20 [6756234] J Lab Clin Med. 1983 Feb;101(2):327-34 [6337226] J Lab Clin Med. 1983 Aug;102(2):151-62 [6553073] Am Rev Respir Dis. 1983 Jul;128(1):132-7 [6191602] Anat Rec. 1983 May;206(1):31-42 [6554048] Biochem J. 1983 Sep 15;214(3):871-7 [6354179] J Lab Clin Med. 1984 Mar;103(3):384-92 [6199445] Am Rev Respir Dis. 1984 Mar;129(3):485-90 [6200017] Environ Res. 1984 Apr;33(2):497-513 [6562016] Am Rev Respir Dis. 1984 Nov;130(5):734-9 [6568097] J Clin Invest. 1984 Nov;74(5):1693-700 [6568228] J Pathol. 1985 Apr;145(4):307-14 [3889245] Biochem J. 1986 Feb 1;233(3):925-7 [3518704] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] Biochem J. 1974 Feb;137(2):387-98 [4207388] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ranitidine-induced granulocytopenia: recurrence with cimetidine administration. AN - 78129437; 3348565 JF - Annals of internal medicine AU - List, A F AU - Beaird, D H AU - Kummet, T AD - Phoenix Veterans Administration Medical Center, Arizona. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 566 EP - 567 VL - 108 IS - 4 SN - 0003-4819, 0003-4819 KW - Cimetidine KW - 80061L1WGD KW - Ranitidine KW - 884KT10YB7 KW - Abridged Index Medicus KW - Index Medicus KW - Bone Marrow -- pathology KW - Humans KW - Middle Aged KW - Recurrence KW - Male KW - Cimetidine -- adverse effects KW - Agranulocytosis -- pathology KW - Ranitidine -- adverse effects KW - Agranulocytosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78129437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Ranitidine-induced+granulocytopenia%3A+recurrence+with+cimetidine+administration.&rft.au=List%2C+A+F%3BBeaird%2C+D+H%3BKummet%2C+T&rft.aulast=List&rft.aufirst=A&rft.date=1988-04-01&rft.volume=108&rft.issue=4&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein kinase C in primary astrocyte cultures: cytoplasmic localization and translocation by a phorbol ester. AN - 78123353; 3346673 AB - The distribution of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in supernatant and particulate fractions of primary cultures of rat astrocytes and its translocation by a phorbol ester were studied. We observed that 91% of protein kinase C activity in astrocytes was in the supernatant fraction, as measured by lysine-rich histone phosphorylation assay. Attempts to uncover latent activity in the particulate fraction were unsuccessful. Approximately 75% of the supernatant protein kinase C activity could be translocated to the particulate fraction by prior treatment (30-60 min) of the cultures with 100 nM 12-O-tetradecanoyl-phorbol 13-acetate (TPA), but not with 4 alpha-phorbol, an inactive phorbol ester. Investigation of endogenous substrates for protein kinase C showed that TPA treatment brought about an increase in phosphorylation in membrane proteins and a decrease in phosphorylation of supernatant proteins. These findings indicate that the distribution of protein kinase C in astrocytes differs substantially from that in whole brain tissue, where approximately two-thirds of the protein kinase C activity is associated with the particulate fraction. Because protein kinase C is concentrated in the cytosol of astrocytes and most of this activity can be translocated to membranes, astrocytes may be particularly well-suited to respond to signals that activate phosphoinositide-linked receptors in brain. JF - Journal of neurochemistry AU - Neary, J T AU - Norenberg, L O AU - Norenberg, M D AD - Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 1179 EP - 1184 VL - 50 IS - 4 SN - 0022-3042, 0022-3042 KW - Detergents KW - 0 KW - Phosphoproteins KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Animals KW - Phosphorylation KW - Cell Membrane -- enzymology KW - Cells, Cultured KW - Kinetics KW - Chromatography, Ion Exchange KW - Detergents -- pharmacology KW - Cytoplasm -- enzymology KW - Animals, Newborn -- metabolism KW - Phosphoproteins -- metabolism KW - Biological Transport -- drug effects KW - Protein Kinase C -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Astrocytes -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78123353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Protein+kinase+C+in+primary+astrocyte+cultures%3A+cytoplasmic+localization+and+translocation+by+a+phorbol+ester.&rft.au=Neary%2C+J+T%3BNorenberg%2C+L+O%3BNorenberg%2C+M+D&rft.aulast=Neary&rft.aufirst=J&rft.date=1988-04-01&rft.volume=50&rft.issue=4&rft.spage=1179&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Religious Activities and Attitudes of Older Adults in a Geriatric Assessment Clinic AN - 61539822; 198801306 AB - An examination of the nature & frequency of organized & private religious activities & the level of commitment or intrinsic religiosity among a consecutive sample of patients (mean age 74.4 years) attending a nonreligious-affiliated geriatric assessment clinic in Ill; questionnaires were completed by 106 Rs, representing 78% of the original sample. Findings reveal high prevalence for orthodox Christian beliefs, religious community activity, prayer, Bible reading, & religious TV viewing. Intrinsic religious commitment was surprisingly strong. Levels of religious activity & intrinsic commitment were lower among patients with cancer, chronic anxiety, depression, & those who smoked cigarettes or drank alcohol; intrinsic commitment was also lower among men with hypertension. Over 50% of Rs noted that all or nearly all of their 5 closest friends were members of their church congregation, testifying to the importance of religious bodies as sources of social support for older persons. These results suggest that religion based in the Judeo-Christian tradition is a powerful cultural, social, & psychological force that is integrally related to both mental & physical health in later life. 6 Tables, 63 References. Modified AA JF - Journal of the American Geriatrics Society AU - Koenig, Harold G AU - Moberg, David O AU - Kvale, James N AD - GRECC #182 Veterans Administration Medical Center, 508 Fulton St Durham NC 27705 Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 362 EP - 374 VL - 36 IS - 4 SN - 0002-8614, 0002-8614 KW - religious activities/commitment, geriatric clinic patients, Illinois KW - questionnaire KW - Illinois KW - Well Being KW - Elderly KW - Religious Behavior KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61539822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Religious+Activities+and+Attitudes+of+Older+Adults+in+a+Geriatric+Assessment+Clinic&rft.au=Koenig%2C+Harold+G%3BMoberg%2C+David+O%3BKvale%2C+James+N&rft.aulast=Koenig&rft.aufirst=Harold&rft.date=1988-04-01&rft.volume=36&rft.issue=4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Illinois; Elderly; Religious Behavior; Well Being ER - TY - JOUR T1 - Social Drinking in Supportive Contexts among College Males AN - 61026383; 89U2953 AB - M Coll students (N = 205) were administered self-report questionnaires to assess the role of social drinking in their social support processes. The quantity & f of social drinking were positively related to 7 of 10 social support variables associated with M network members, but only 1 of 10 F support variables. Rs reported receiving 50% of their companionship support & 25% of their emotional support while drinking. Rs also received a higher proportion of all types of support while drinking when support sources were M than when they were F. These results are consistent with previous studies' findings that social drinking & social support are positively related. 3 Tables, 13 References. Modified AA JF - Journal of Youth and Adolescence AU - Burda, Philip C AU - Vaux, Alan C AD - Psychology Service 116B Veterans Administration Medical Center, Miami FL 33125 Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 165 EP - 171 VL - 17 IS - 2 SN - 0047-2891, 0047-2891 KW - social drinking-support relationship, college males vs females KW - questionnaire KW - Males KW - Drinking Behavior KW - College Students KW - Social Support KW - article KW - 1939: the family and socialization; adolescence & youth KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61026383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Youth+and+Adolescence&rft.atitle=Social+Drinking+in+Supportive+Contexts+among+College+Males&rft.au=Burda%2C+Philip+C%3BVaux%2C+Alan+C&rft.aulast=Burda&rft.aufirst=Philip&rft.date=1988-04-01&rft.volume=17&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Youth+and+Adolescence&rft.issn=00472891&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JYADA6 N1 - SubjectsTermNotLitGenreText - Males; Drinking Behavior; Social Support; College Students ER - TY - JOUR T1 - Ensuring Validity Using Coworker Samples: A Situationally Driven Approach AN - 60992963; 89U1162 AB - In program evaluation, when rigorous methodologies are not applicable, theoretical or situationally driven evaluations have been developed in which the situation itself can serve as a useful research guide. An example is given of a managerial training program in which 2 subsamples of coworkers -- the supervisors & subordinates -- were interviewed (N = 10 & 15, respectively) & their assessments of program impact compared. The subsamples revealed a similar ability to judge both specific & overall impact. The methodology strengthened the validity of the findings. 3 Tables, 23 References. Modified HA JF - Evaluation Review AU - Calloway, Michael AU - Belyea, Michael J AD - c/o Belyea -- Veterans Administration Medical Center, 508 Fulton St Durham NC 27705 Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 186 EP - 195 VL - 12 IS - 2 SN - 0193-841X, 0193-841X KW - situationally driven program evaluation KW - survey data KW - managerial training program participants KW - Methodology (Data Collection) KW - Validity KW - Program Evaluation KW - article KW - 0104: methodology and research technology; research methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60992963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+Review&rft.atitle=Ensuring+Validity+Using+Coworker+Samples%3A+A+Situationally+Driven+Approach&rft.au=Calloway%2C+Michael%3BBelyea%2C+Michael+J&rft.aulast=Calloway&rft.aufirst=Michael&rft.date=1988-04-01&rft.volume=12&rft.issue=2&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Evaluation+Review&rft.issn=0193841X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - EVREDL N1 - SubjectsTermNotLitGenreText - Program Evaluation; Validity; Methodology (Data Collection) ER - TY - JOUR T1 - IGF-I increases c-fos expression in FRTL5 rat thyroid cells by activating the c-fos promoter. AN - 78167449; 3355549 AB - We studied the effect of IGF-1 on c-fos mRNA expression in FRTL5 rat thyroid cells. IFG-1, or calf serum, transiently increased c-fos mRNA levels in quiescent FRTL5 cells, with the latter being more potent. This increase was prevented by actinomycin D. FRTL5 cells were stably transfected with the c-fos promoter linked upstream to the reporter gene chloramphenicol acetyl transferase (CAT). Calf serum and IGF-1 increased c-fos promoter activity in a prolonged manner, and to an equal degree. Our data indicate that IGF-1, as well as additional factor(s) in serum, increase c-fos mRNA levels, at least in part, by activation of the c-fos promoter. JF - Biochemical and biophysical research communications AU - Damante, G AU - Cox, F AU - Rapoport, B AD - Department of Medicine, Veterans' Administration Medical Center, San Francisco, California 94121. Y1 - 1988/03/30/ PY - 1988 DA - 1988 Mar 30 SP - 1194 EP - 1199 VL - 151 IS - 3 SN - 0006-291X, 0006-291X KW - RNA, Messenger KW - 0 KW - Somatomedins KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Thyrotropin KW - 9002-71-5 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Rats KW - Blood KW - Animals KW - Thyrotropin -- pharmacology KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Drug Synergism KW - Promoter Regions, Genetic KW - Somatomedins -- pharmacology KW - Oncogenes KW - Thyroid Gland -- drug effects KW - Gene Expression Regulation -- drug effects KW - Insulin-Like Growth Factor I -- pharmacology KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78167449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=IGF-I+increases+c-fos+expression+in+FRTL5+rat+thyroid+cells+by+activating+the+c-fos+promoter.&rft.au=Damante%2C+G%3BCox%2C+F%3BRapoport%2C+B&rft.aulast=Damante&rft.aufirst=G&rft.date=1988-03-30&rft.volume=151&rft.issue=3&rft.spage=1194&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-11 N1 - Date created - 1988-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of mopidamol on survival in carcinoma of the lung and colon: final report of Veterans Administration Cooperative Study No. 188. AN - 78126587; 2830407 AB - Mopidamol (RA-233), a derivative of dipyridamole, is a phosphodiesterase inhibitor that has been shown previously to limit progression of malignancy in certain experimental animal models and in a pilot study in humans. RA-233 plus chemotherapy was compared with chemotherapy alone in a 5-year double-blind trial involving 719 patients with advanced carcinomas of the lung and of the colon. RA-233 treatment was associated with a statistically significant prolongation of survival in patients with non-small cell lung cancer (N-SCLC) limited to one hemithorax and with reduction in mean plasma fibrogen concentration. RA-233 was not toxic. The favorable effects on survival could not be explained by any factor other than the RA-233 treatment. In other tumor categories tested, no differences in survival were observed. These results suggest that RA-233 is useful in the treatment of N-SCLC of limited extent. They also suggest that therapeutic intervention aimed at modified intracellular pathways might constitute a novel investigative approach to the treatment of cancer. JF - Journal of the National Cancer Institute AU - Zacharski, L R AU - Moritz, T E AU - Baczek, L A AU - Rickles, F R AU - Edwards, R L AU - Forman, W B AU - Forcier, R J AU - Cornell, C J AU - Haakenson, C M AU - Ballard, H S AD - Veterans Administration (VA) Medical Center, White River Junction, VT 05001. Y1 - 1988/03/16/ PY - 1988 DA - 1988 Mar 16 SP - 90 EP - 97 VL - 80 IS - 2 SN - 0027-8874, 0027-8874 KW - Pyrimidines KW - 0 KW - Mopidamol KW - 4Q0IWP8B8O KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Prospective Studies KW - Oncogenes KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Cyclic AMP -- analysis KW - Pyrimidines -- therapeutic use KW - Colonic Neoplasms -- mortality KW - Carcinoma -- drug therapy KW - Lung Neoplasms -- drug therapy KW - Colonic Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Mopidamol -- therapeutic use KW - Mopidamol -- pharmacology KW - Mopidamol -- adverse effects KW - Carcinoma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78126587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Effect+of+mopidamol+on+survival+in+carcinoma+of+the+lung+and+colon%3A+final+report+of+Veterans+Administration+Cooperative+Study+No.+188.&rft.au=Zacharski%2C+L+R%3BMoritz%2C+T+E%3BBaczek%2C+L+A%3BRickles%2C+F+R%3BEdwards%2C+R+L%3BForman%2C+W+B%3BForcier%2C+R+J%3BCornell%2C+C+J%3BHaakenson%2C+C+M%3BBallard%2C+H+S&rft.aulast=Zacharski&rft.aufirst=L&rft.date=1988-03-16&rft.volume=80&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specificity, schedule, and proliferation dependence of infused L-histidinol after 5-fluorouracil in mice. AN - 78116492; 3345520 AB - L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into the cell cycle through protein deficiency, while allowing malignant cells, permissive for protein starvation, to continue to cycle, thus maintaining sensitivity for cycle specific anticancer agents. Reported in this paper is the confirmation of these L-histidinol-FUra effects. However, a modification was made by which more L-histidinol could be given and more consistent protection of whole animals demonstrated. Further, an optimal schedule of L-histidinol was defined in which FUra preceded L-histidinol infusion. Finally, the specificity and proliferation dependence of this schedule was evaluated on colony forming units-spleen in resting and proliferating state, colony forming units-granulocyte-macrophage, and L1210 leukemia. This demonstrates that the FUra/L-histidinol combination indeed protects only normal cells but that the postulated proliferation dependence is absent, indicating an alternate biological mechanism. JF - Cancer research AU - Edelstein, M B AU - Heilbrun, L K AD - Veterans Administration Medical Center, Allen Park, Michigan 48101. Y1 - 1988/03/15/ PY - 1988 DA - 1988 Mar 15 SP - 1470 EP - 1475 VL - 48 IS - 6 SN - 0008-5472, 0008-5472 KW - Imidazoles KW - 0 KW - Histidinol KW - 501-28-0 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Mice, Inbred DBA KW - Hematopoietic Stem Cells -- drug effects KW - Histidinol -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Histidinol -- toxicity KW - Imidazoles -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78116492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Specificity%2C+schedule%2C+and+proliferation+dependence+of+infused+L-histidinol+after+5-fluorouracil+in+mice.&rft.au=Edelstein%2C+M+B%3BHeilbrun%2C+L+K&rft.aulast=Edelstein&rft.aufirst=M&rft.date=1988-03-15&rft.volume=48&rft.issue=6&rft.spage=1470&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effector mechanism of tumor immunity in murine plasmacytoma. AN - 78114349; 3257896 AB - The development of concomitant tumor immunity to plasmacytoma (PC) was previously demonstrated by the detection of splenic immune T-lymphocytes that inhibited the growth of PC in local adoptive transfer (Winn) assay. This immunity was down-regulated by cyclophosphamide-sensitive suppressor T-cells. The effector mechanism was further studied. It was found that immune spleen cells contained no cytotoxic T-lymphocytes as determined by 51Cr release assay. Immune spleen cells, however, exerted a cytostatic effect on PC cells in vitro; coculture of immune spleen cells with PC cells inhibited the [3H]thymidine uptake by tumor cells. No in vitro generation of cytolytic activity was observed. The cytostatic effector cells were found to be radiosensitive, nonadherent, Thy-1+, Lyt-1-2+ lymphocytes that required direct cell-cell contact for cytostasis. Plasmacytoma arising from transplants of mixtures of PC cells and immune spleen cells had a slower growth rate in vivo and incorporated less [3H]thymidine in vitro, findings consistent with the cytostatic effect of immune spleen cells. Studies comparing cytostatic cells assayed in vitro and immune splenic effector cells assayed in vivo (Winn assay) revealed that the former were short-lived (less than 26 days), high dose cyclophosphamide (200 mg/kg) resistant, and cross-reacting to other PC, whereas the latter were long-lived (greater than or equal to 102 days), high dose cyclophosphamide sensitive, and individual tumor specific. Immune spleen cells, however, could inhibit heterologous PC growth in vivo, if the homologous PC were also present. These findings are consistent with the hypothesis that the concomitant tumor immunity in PC involves terminal cytostatic effector T-cells with a broader target spectrum and tumor-specific helper T-cells that are required for clonal expansion and maturation of cytostatic cells in vivo. JF - Cancer research AU - Chen, Y H AU - Anderson, A B AD - Veterans Administration West Side Medical Center, Chicago, Illinois. Y1 - 1988/03/15/ PY - 1988 DA - 1988 Mar 15 SP - 1398 EP - 1403 VL - 48 IS - 6 SN - 0008-5472, 0008-5472 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Phenotype KW - Cytotoxicity, Immunologic KW - Animals KW - Spleen -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Cyclophosphamide -- pharmacology KW - Cell Division KW - Plasmacytoma -- pathology KW - Plasmacytoma -- immunology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78114349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Effector+mechanism+of+tumor+immunity+in+murine+plasmacytoma.&rft.au=Chen%2C+Y+H%3BAnderson%2C+A+B&rft.aulast=Chen&rft.aufirst=Y&rft.date=1988-03-15&rft.volume=48&rft.issue=6&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Venous, arterial, and arterialized-venous blood ammonia levels and their relationship to hepatic encephalopathy after propranolol. AN - 85213794; pmid-3344727 AB - To assess side effects of propranolol in the treatment of portal hypertension, we measured blood ammonia in 14 cirrhotics before and after administration of propranolol, and in six cirrhotics before and after placebo. We evaluated ammonia blood levels obtained from three sites: venous, arterial, and arterialized-venous, obtained by warming the forearm. Ammonia concentration of arterial and arterialized-venous blood were abnormal for all cirrhotics studied and significantly greater than the ammonia concentration of venous blood (p less than 0.01). When propranolol was administered to patients with alcoholic cirrhosis and marginal liver function, as reflected by ammonia levels above 60 microM, it caused a significant increase in ammonia levels in arterialized-venous and arterial, but not in venous, blood (p less than 0.05). Propranolol caused a significant increase in the time required to perform sensitive psychometric tests (p less than 0.05). Encephalopathy usually became clinically apparent when the mean of the arterial and arterialized-venous blood ammonia levels rose above 122 microM. JF - The American Journal of Gastroenterology AU - Snady, H AU - Lieber, C S AD - Section of Liver Disease and Nutrition, Veterans Administration Medical Center, Bronx, New York. PY - 1988 SP - 249 EP - 255 VL - 83 IS - 3 SN - 0002-9270, 0002-9270 KW - Hepatic Encephalopathy KW - Veins KW - Support, U.S. Gov't, P.H.S. KW - Propranolol KW - Human KW - Arteries KW - Ammonia KW - Support, U.S. Gov't, Non-P.H.S. KW - Psychomotor Performance KW - Liver Cirrhosis KW - Hypertension, Portal KW - Psychometrics KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Venous%2C+arterial%2C+and+arterialized-venous+blood+ammonia+levels+and+their+relationship+to+hepatic+encephalopathy+after+propranolol.&rft.au=Snady%2C+H%3BLieber%2C+C+S&rft.aulast=Snady&rft.aufirst=H&rft.date=1988-03-01&rft.volume=83&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mandibular reconstruction in an irradiated field using median sternotomy and anterior rib axial graft. AN - 85189114; pmid-3343886 AB - Mandibular reconstruction in an irradiated field continues to be a challenge to the reconstructing surgeon. Several methods use rib grafts to bring vascularized tissue to the mandibular region. A median sternotomy provides excellent exposure to harvest the internal mammary artery and anterior axial rib graft for subsequent mandibular reconstruction. The modified technique described provides an alternative method of bringing a vascularized rib graft to an irradiated field for mandibular reconstruction avoiding multiple rib resections and microvascular anastomosis. This technique has been used in two patients who had anterior mandibular resection and irradiation therapy for advanced squamous cell carcinoma. The results from this technique were excellent and without major complications. JF - The Laryngoscope AU - Cook, D W AU - Winek, T AU - Yeager, R AU - Olivier, T AU - McConnell, D AU - Sasaki, T AD - Department of Surgery, Portland Veterans Administration Medical Center, OR 97207. PY - 1988 SP - 349 EP - 352 VL - 98 IS - 3 SN - 0023-852X, 0023-852X KW - Mandible KW - Ribs KW - Graft Survival KW - Human KW - Sternum KW - Surgical Flaps KW - Mandibular Neoplasms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85189114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Mandibular+reconstruction+in+an+irradiated+field+using+median+sternotomy+and+anterior+rib+axial+graft.&rft.au=Cook%2C+D+W%3BWinek%2C+T%3BYeager%2C+R%3BOlivier%2C+T%3BMcConnell%2C+D%3BSasaki%2C+T&rft.aulast=Cook&rft.aufirst=D&rft.date=1988-03-01&rft.volume=98&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cholesterol-induced atherosclerosis in the rabbit: effect of dimethyl sulfoxide on existing lesions. AN - 78777959; 3252028 AB - Earlier studies have established that the analgesic and anti-inflammatory compound, dimethyl sulfoxide (DMSO), was effective in preventing atherosclerosis in cholesterol-fed rabbits. In the present studies, the effect of DMSO on existing atherosclerotic lesions in cholesterol-fed rabbits was investigated. Rabbits were placed on an atherogenic diet containing 1% cholesterol for a period of 10 weeks. At the end of the 10-week period, the rabbits were randomly divided into two groups: one group was placed on a control diet consisting of regular rabbit chow for an additional 12-week period, whereas the remaining group was continued on the atherogenic diet. During this period half of the rabbits in each of these groups were treated with DMSO (approximately 5 g/kg) which was included in their drinking water. Food consumption and fluid intakes were monitored daily and body weights at weekly intervals. Total serum cholesterol levels were measured at periodic intervals. Lipid deposits in the eye which accompany atherosclerosis were examined before and at 12 weeks after institution of the new dietary regimens. At the end of 12 weeks, all rabbits were killed and the thoracic aortas were examined for changes in the extent of atherosclerosis. Food consumption and body weight increased in rabbits on the control diet and in those treated with DMSO. Those maintained on the atherogenic diet showed little change in food intake or body weight. Fluid intake was significantly elevated in all rabbits placed on DMSO. Serum cholesterol levels returned to normal in all rabbits on the control diet. Serum cholesterol levels remained unchanged in rabbits kept on the atherogenic diet alone.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Fani, K AU - Debons, A F AU - Jimenez, F A AU - Hoover, E L AD - Department of Pathology, Veterans Administration Medical Center, Brooklyn, New York. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 1145 EP - 1149 VL - 244 IS - 3 SN - 0022-3565, 0022-3565 KW - Cholesterol KW - 97C5T2UQ7J KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Drinking -- drug effects KW - Body Weight -- drug effects KW - Aorta -- pathology KW - Rabbits KW - Eye -- pathology KW - Cholesterol -- toxicity KW - Male KW - Dimethyl Sulfoxide -- pharmacology KW - Arteriosclerosis -- drug therapy KW - Arteriosclerosis -- chemically induced KW - Arteriosclerosis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78777959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Cholesterol-induced+atherosclerosis+in+the+rabbit%3A+effect+of+dimethyl+sulfoxide+on+existing+lesions.&rft.au=Fani%2C+K%3BDebons%2C+A+F%3BJimenez%2C+F+A%3BHoover%2C+E+L&rft.aulast=Fani&rft.aufirst=K&rft.date=1988-03-01&rft.volume=244&rft.issue=3&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-10 N1 - Date created - 1989-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the toxicity of the radiocontrast agents, iopamidol and diatrizoate, to rabbit renal proximal tubule cells in vitro. AN - 78775096; 3252027 AB - Radiographic contrast agent-induced acute renal failure is an increasingly recognized clinical event. Multiple factors have been implicated in its development. Recent experiments have demonstrated that sodium diatrizoate, a common ionic radiocontrast agent, is moderately toxic to proximal tubule cells in vitro, and that this toxicity is enhanced by hypoxia. In this study, we compare toxicities of the nonionic radiocontrast agent, iopamidol, and the commonly used ionic contrast agent, diatrizoate. Suspensions enriched in proximal tubule segments were exposed for 82.5 min to 10 or 25 mM diatrizoate or 10 or 25 mM iopamidol with or without 22.5 min or 30 min of hypoxia. Cell viability parameters, including basal and uncoupled respiratory rates, tubule cell potassium and calcium levels and cell ATP content were measured. No consistent differences in tubule viability parameters were observed between tubule suspensions exposed to 10 mM concentrations of the radiocontrast agents during either oxygenated or hypoxic conditions. Under oxygenated conditions, both 25 mM iopamidol and diatrizoate exposure produced greater metabolic alterations in renal tubules than control conditions, but the effects were not statistically significant. With concomitant hypoxia, the alterations after 25 mM diatrizoate exposure were significantly greater than those seen after exposure to 25 mM iopamidol. Iopamidol had less of a detrimental effect on renal tubule potassium content and both basal and uncoupled respiratory rates than that of diatrizoate under these conditions. Thus, diatrizoate is more toxic to rabbit renal proximal tubule cells than iopamidol in vitro, and this difference in toxicity is enhanced by hypoxia.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Messana, J M AU - Cieslinski, D A AU - Nguyen, V D AU - Humes, H D AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 1139 EP - 1144 VL - 244 IS - 3 SN - 0022-3565, 0022-3565 KW - Diatrizoate KW - 117-96-4 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Iopamidol KW - JR13W81H44 KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Space life sciences KW - Animals KW - Analysis of Variance KW - Oxygen Consumption KW - Calcium -- analysis KW - In Vitro Techniques KW - Hypoxia -- metabolism KW - Adenosine Triphosphate -- analysis KW - Rabbits KW - Potassium -- analysis KW - Kidney Tubules, Proximal -- analysis KW - Iopamidol -- toxicity KW - Kidney Tubules, Proximal -- drug effects KW - Diatrizoate -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78775096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Comparison+of+the+toxicity+of+the+radiocontrast+agents%2C+iopamidol+and+diatrizoate%2C+to+rabbit+renal+proximal+tubule+cells+in+vitro.&rft.au=Messana%2C+J+M%3BCieslinski%2C+D+A%3BNguyen%2C+V+D%3BHumes%2C+H+D&rft.aulast=Messana&rft.aufirst=J&rft.date=1988-03-01&rft.volume=244&rft.issue=3&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-10 N1 - Date created - 1989-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Experimental secondarily generalized convulsive status epilepticus induced by D,L-homocysteine thiolactone. AN - 78559746; 3197690 AB - Secondarily generalized convulsive status epilepticus was induced by intraperitoneal (i.p.) injection of D,L-homocysteine thiolactone to rats with actively epileptogenic cobalt lesions in motor cortex. This induced focal motor seizures which secondarily generalized. Control animals not treated with antiepileptic drugs had a mean of 18.3 generalized convulsions over a mean period of 103.8 min. Electrographic patterns seen during status epilepticus are described and are very similar to those seen during human status epilepticus. Phenytoin, phenobarbital, diazepam and lorazepam were all effective in arresting the generalized seizures when given i.p. after the second such seizure. Efficacy was serum drug concentration dependent. Concentrations effective in arrest of generalized seizures in this model are similar to those reported to be effective in the treatment of human status epilepticus. Diazepam ED50s for control of generalized tonic-clonic seizures and for arrest of all seizure activity were determined. JF - Epilepsy research AU - Walton, N Y AU - Treiman, D M AD - Neurology Service, Veterans Administration Medical Center, Los Angeles, CA 90073. PY - 1988 SP - 79 EP - 86 VL - 2 IS - 2 SN - 0920-1211, 0920-1211 KW - Anticonvulsants KW - 0 KW - Convulsants KW - Homocysteine KW - 0LVT1QZ0BA KW - homocysteine thiolactone KW - D5H88XF24X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Electroencephalography KW - Anticonvulsants -- therapeutic use KW - Male KW - Status Epilepticus -- chemically induced KW - Status Epilepticus -- physiopathology KW - Status Epilepticus -- drug therapy KW - Convulsants -- administration & dosage KW - Homocysteine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78559746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=Experimental+secondarily+generalized+convulsive+status+epilepticus+induced+by+D%2CL-homocysteine+thiolactone.&rft.au=Walton%2C+N+Y%3BTreiman%2C+D+M&rft.aulast=Walton&rft.aufirst=N&rft.date=1988-03-01&rft.volume=2&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-17 N1 - Date created - 1989-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychotropic drug interactions in the patient with late-onset depression or psychosis. Part 2. AN - 78268961; 2898136 AB - We now conclude our discussion of psychotropic drug interactions in the late-life depression or psychosis patient. We have attempted to point out the more common drug interactions, while also mentioning less well-reported, yet potentially important interactions. The outcome of such adverse reactions as we have described herein is usually of greater concern in older patients. Accordingly, this population would benefit considerably from accurate reporting of any suspected drug interactions. Although most drug interactions are usually somewhat predictable, it is very important that those interactions that are not expected otherwise be well documented. As stated elsewhere in this review, a good basic knowledge of the pharmacology of the agents in question will serve the clinician and his or her patient well. JF - The Psychiatric clinics of North America AU - Rizos, A L AU - Sargenti, C J AU - Jeste, D V AD - Department of Pharmacy, Veterans Administration Medical Center, San Diego, California. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 253 EP - 277 VL - 11 IS - 1 SN - 0193-953X, 0193-953X KW - Antidepressive Agents, Tricyclic KW - 0 KW - Antipsychotic Agents KW - Sympathomimetics KW - Cimetidine KW - 80061L1WGD KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Sympathomimetics -- adverse effects KW - Drug Interactions KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Cimetidine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Male KW - Female KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Lithium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78268961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Psychotropic+drug+interactions+in+the+patient+with+late-onset+depression+or+psychosis.+Part+2.&rft.au=Rizos%2C+A+L%3BSargenti%2C+C+J%3BJeste%2C+D+V&rft.aulast=Rizos&rft.aufirst=A&rft.date=1988-03-01&rft.volume=11&rft.issue=1&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-26 N1 - Date created - 1988-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuroleptics and alternative treatments. Management of behavioral symptoms and psychosis in Alzheimer's disease and related conditions. AN - 78267739; 2898133 AB - Behavioral problems, and even psychotic symptoms, are universally acknowledged as among the most distressing consequences of dementia. A majority of patients experience either or both at some time during the course of dementia. Agitation is so common that accurate prevalence rates are difficult to ascertain; the available data suggest approximately 70 to 80 per cent of patients manifest this behavior in some form. Psychotic symptoms in some form occur less frequently, but perhaps affect up to half of demented patients at some time. Neuroleptic medications are among the psychoactive drugs most frequently prescribed for the demented elderly, yet they carry the risk of considerable morbidity from side effects, both acute (extrapyramidal syndromes, cardiovascular toxicity, anticholinergic effects) and chronic (tardive dyskinesia). They are most widely used for behavioral and psychotic symptoms; however, their efficacy for these problems is far from unequivocally established. The multiple medical problems of the elderly add to the complexity of diagnosing and managing these symptoms. Systematic delineation of the etiology, course, and prognosis of behavioral and psychotic symptoms may clarify the indications for such treatment. Further research on effective adjuncts and alternatives to neuroleptic treatment in the demented elderly may facilitate patient management, maximizing efficacy and reducing potential adverse consequences. JF - The Psychiatric clinics of North America AU - Wragg, R E AU - Jeste, D V AD - Department of Psychiatry, San Diego Veterans Administration Medical Center, La Jolla, California. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 195 EP - 213 VL - 11 IS - 1 SN - 0193-953X, 0193-953X KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - Psychomotor Agitation -- drug therapy KW - Alzheimer Disease -- complications KW - Antipsychotic Agents -- therapeutic use KW - Psychomotor Agitation -- etiology KW - Psychotic Disorders -- etiology KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78267739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Neuroleptics+and+alternative+treatments.+Management+of+behavioral+symptoms+and+psychosis+in+Alzheimer%27s+disease+and+related+conditions.&rft.au=Wragg%2C+R+E%3BJeste%2C+D+V&rft.aulast=Wragg&rft.aufirst=R&rft.date=1988-03-01&rft.volume=11&rft.issue=1&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-26 N1 - Date created - 1988-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug-induced psychosis and depression in the elderly. AN - 78265474; 2898132 AB - This article discusses drug-induced psychosis and depression in the elderly population. Selected reports with particular emphasis on the geriatric population are evaluated with histamine blockers, antiparkinson, anti-inflammatory, antituberculosis, antineoplastic, antidepressant, anticonvulsant, cardiac, antihypertensive, and steroid drugs. Particular emphasis is placed on possible mechanisms of these side effects and factors contributing to increased incidence in the elderly population. In review, the clinician is advised to use special caution when prescribing these agents in the elderly considering increasing patterns of drug-induced psychosis and depression. JF - The Psychiatric clinics of North America AU - Wood, K A AU - Harris, M J AU - Morreale, A AU - Rizos, A L AD - Department of Pharmacy, Veterans Administration Hospital, San Diego, California. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 167 EP - 193 VL - 11 IS - 1 SN - 0193-953X, 0193-953X KW - Analgesics KW - 0 KW - Antiparkinson Agents KW - Histamine H1 Antagonists KW - Psychotropic Drugs KW - Index Medicus KW - Antiparkinson Agents -- adverse effects KW - Humans KW - Histamine H1 Antagonists -- adverse effects KW - Psychotropic Drugs -- adverse effects KW - Analgesics -- adverse effects KW - Depressive Disorder -- chemically induced KW - Aged KW - Psychoses, Substance-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78265474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Drug-induced+psychosis+and+depression+in+the+elderly.&rft.au=Wood%2C+K+A%3BHarris%2C+M+J%3BMorreale%2C+A%3BRizos%2C+A+L&rft.aulast=Wood&rft.aufirst=K&rft.date=1988-03-01&rft.volume=11&rft.issue=1&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-26 N1 - Date created - 1988-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction of caffeine with acetaminophen in mice: schedule dependency of the antagonism by caffeine of acetaminophen hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl ether. AN - 78195781; 3363219 AB - Administration of caffeine (CAF) to mice as early as 6 hr prior to injection of a hepatotoxic but nonlethal dose of acetaminophen (ACM) significantly antagonized the hepatotoxic action of ACM as judged by serum levels of alanine aminotransferase (ALT) activity. Administration of CAF after ACM produced complete antagonism only when CAF was given no later than 1 hr after ACM. Administration of CAF daily for 3 days prior to injection of ACM enhanced ACM toxicity markedly, but little or no toxicity ensued when CAF-pretreated mice received ACM followed immediately by CAF. The four primary metabolites of CAF, 1,3-dimethylxanthine (theophylline), 3,7-dimethylxanthine (theobromine), 1,7-dimethylxanthine (paraxanthine), and 1,3,7-trimethyluric acid were effective and virtually complete antagonists of ACM-induced hepatotoxicity when given immediately after ACM, as were the secondary metabolites, 1-methylxanthine and 1,3-dimethyluric acid. Allopurinol, which reduces theophylline clearance, increases the rate of oxidative N-demethylation of theophylline to 1-methylxanthine, and inhibits conversion of 1-methylxanthine to 1-methyluric acid, was also a dose-dependent antagonist of ACM-induced hepatotoxicity. The hepatotoxic response of mice to ACM is exaggerated by a brief period of diethyl ether anesthesia; CAF given immediately after ACM to previously anesthetized mice suppressed this response and maintained serum ALT levels at control values. It is suggested that CAF and its primary metabolites compete with ACM for biotransformation by the cytochrome P-450 mixed function oxidase system, thereby reducing the rate of formation of the hepatotoxic ACM metabolite. JF - Research communications in chemical pathology and pharmacology AU - Gale, G R AU - Smith, A B AD - Veterans Administration Medical Center, Charleston, SC 29403. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 305 EP - 320 VL - 59 IS - 3 SN - 0034-5164, 0034-5164 KW - Ethyl Ethers KW - 0 KW - Ether KW - 0F5N573A2Y KW - Acetaminophen KW - 362O9ITL9D KW - Caffeine KW - 3G6A5W338E KW - Ethanol KW - 3K9958V90M KW - Allopurinol KW - 63CZ7GJN5I KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Alanine Transaminase -- blood KW - Ethanol -- pharmacology KW - Biotransformation KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Mice, Inbred DBA KW - Caffeine -- metabolism KW - Allopurinol -- pharmacology KW - Liver -- drug effects KW - Ether -- pharmacology KW - Caffeine -- pharmacology KW - Acetaminophen -- antagonists & inhibitors KW - Ethyl Ethers -- pharmacology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78195781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Interaction+of+caffeine+with+acetaminophen+in+mice%3A+schedule+dependency+of+the+antagonism+by+caffeine+of+acetaminophen+hepatotoxicity+and+the+effects+of+caffeine+metabolites%2C+allopurinol%2C+and+diethyl+ether.&rft.au=Gale%2C+G+R%3BSmith%2C+A+B&rft.aulast=Gale&rft.aufirst=G&rft.date=1988-03-01&rft.volume=59&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Localization of brainstem sites which mediate alfentanil-induced muscle rigidity in the rat. AN - 78193281; 3129743 AB - Previous work has demonstrated that direct injections of methylnaloxonium (MN), a relatively lipophobic quaternary opiate antagonist, in the area of the nucleus raphe pontis (RPn) significantly attenuated alfentanil-induced rigidity. It was hypothesized that other hindbrain sites, particularly the other raphe nuclei, might play a role in this rigidity. Therefore, a study was performed in which 57 rats, divided into four groups, were implanted with chronic guide cannulae directed at brain sites anterior, lateral, or posterior to the RPn. After each animal was pretreated with intracerebral injections of MN, alfentanil (0.5 mg/kg) was administered subcutaneously. Electromyographic activity was recorded from the gastrocnemius muscle as a measure of hindlimb rigidity. Each animal was subsequently injected at 4 to 5 day intervals with MN two additional times at sites 1 and 2 mm deeper, respectively, than the initial injection. Data were thus obtained on animals treated with either MN or saline at 3 successive histologically identified sites which were either anterior, lateral or posterior to the RPn. The administration of MN into two specific sites in the region just lateral to the nucleus raphe pontis significantly [F(1,38) = 18.68 and 5.02 respectively, p less than 0.05] reversed the rigidity produced by systemic alfentanil administration. There was a weak effect of MN injections anterior to the RPn but this could not be localized to any one site. These results suggest that discrete brainstem regions involved in opiate action can be sensitively and selectively identified by direct intracranial injections of a lipophobic opiate antagonist.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Pharmacology, biochemistry, and behavior AU - Weinger, M B AU - Cline, E J AU - Smith, N T AU - Blasco, T A AU - Koob, G F AD - Department of Anesthesiology, Veterans Administration Medical Center, San Diego, CA 92161. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 573 EP - 580 VL - 29 IS - 3 SN - 0091-3057, 0091-3057 KW - Quaternary Ammonium Compounds KW - 0 KW - Alfentanil KW - 1N74HM2BS7 KW - Naloxone KW - 36B82AMQ7N KW - N-methylnaloxone KW - 73232-50-5 KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Raphe Nuclei -- physiology KW - Naloxone -- toxicity KW - Naloxone -- analogs & derivatives KW - Raphe Nuclei -- drug effects KW - Brain Stem -- drug effects KW - Fentanyl -- toxicity KW - Brain Stem -- anatomy & histology KW - Brain Stem -- physiology KW - Fentanyl -- analogs & derivatives KW - Muscle Rigidity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78193281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Localization+of+brainstem+sites+which+mediate+alfentanil-induced+muscle+rigidity+in+the+rat.&rft.au=Weinger%2C+M+B%3BCline%2C+E+J%3BSmith%2C+N+T%3BBlasco%2C+T+A%3BKoob%2C+G+F&rft.aulast=Weinger&rft.aufirst=M&rft.date=1988-03-01&rft.volume=29&rft.issue=3&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fluorine-19 NMR imaging of glucose metabolism. AN - 78185896; 3362066 AB - Metabolic imaging reflecting glucose metabolism in the glycolytic and aldose reductase sorbitol (ARS) pathways was performed noninvasively in rat using fluorinated glucose analogs, 2-fluoro-2-deoxy-D-glucose (2-FDG) or 3-fluoro-3-deoxy-D-glucose (3-FDG), and fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging. 19F images of 2-FDG-6-phosphate, a main metabolite of 2-FDG in the glycolytic pathway, showed high glucose utilization in the brain, spinal cord, and heart. Images of 3-fluoro-3-deoxy-D-sorbitol (3-FDSL), a main metabolite of 3-FDG in the ARS pathway, demonstrated the heterogeneous nature of the spatial distribution of aldose reductase activities, being highest in the brain and lens. The extremely low toxicity of 3-FDG indicates promise for clinical application of 3-FDG NMR imaging. JF - Magnetic resonance in medicine AU - Nakada, T AU - Kwee, I L AU - Card, P J AU - Matwiyoff, N A AU - Griffey, B V AU - Griffey, R H AD - Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 307 EP - 313 VL - 6 IS - 3 SN - 0740-3194, 0740-3194 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - 3-deoxy-3-fluoro-D-glucose KW - 14049-03-7 KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Rats KW - Animals KW - Spinal Cord -- metabolism KW - Deoxyglucose -- analogs & derivatives KW - Brain -- metabolism KW - Myocardium -- metabolism KW - Male KW - Magnetic Resonance Imaging KW - Glucose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78185896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+resonance+in+medicine&rft.atitle=Fluorine-19+NMR+imaging+of+glucose+metabolism.&rft.au=Nakada%2C+T%3BKwee%2C+I+L%3BCard%2C+P+J%3BMatwiyoff%2C+N+A%3BGriffey%2C+B+V%3BGriffey%2C+R+H&rft.aulast=Nakada&rft.aufirst=T&rft.date=1988-03-01&rft.volume=6&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Magnetic+resonance+in+medicine&rft.issn=07403194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-31 N1 - Date created - 1988-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Efficacy and safety of low-dose intravenous versus intramuscular vitamin K in parenteral nutrition patients. AN - 78182877; 3129593 AB - Efficacy and safety of intravenous and intramuscular vitamin K were compared prospectively in patients receiving total parenteral nutrition. Sixty patients randomly received either a 1-mg daily iv injection (iv group) or a 10-mg weekly injection group (im group). Efficacy was determined by the prolongation of twice-weekly prothrombin (PT) and activated partial thromboplastin (APTT) times. The prolongation of both was not significantly different between the im and iv groups. The percent of PTs outside the normal range was not different for the two groups, although the iv group had more APTT values outside the range than did the im group (p = 0.002). The number of adverse reactions reported in the iv (5) and im (4) groups was also similar. Reactions were minor, not reproducible, and all patients recovered without sequelae. PT results from the iv and im groups were combined and compared to values from 28 patients in an earlier study who did not receive vitamin K. PTs in the no-vitamin K group were significantly prolonged over the vitamin K group (p = 0.0004). The results confirm that regular addition of vitamin K to TPN regimens decreases the incidence of elevated PTs. When administered appropriately, iv and im administration of vitamin K appear to be equally safe and effective in maintaining normal PTs and APTTs. JF - JPEN. Journal of parenteral and enteral nutrition AU - Schepers, G P AU - Dimitry, A R AU - Eckhauser, F E AU - Kirking, D M AD - Department of Pharmacy, Veterans Administration Medical Center, Ann Arbor, MI 48105. PY - 1988 SP - 174 EP - 177 VL - 12 IS - 2 SN - 0148-6071, 0148-6071 KW - Vitamin K KW - 12001-79-5 KW - Index Medicus KW - Prospective Studies KW - Injections, Intravenous KW - Humans KW - Injections, Intramuscular KW - Middle Aged KW - Prothrombin Time KW - Gastrointestinal Hemorrhage -- chemically induced KW - Male KW - Female KW - Partial Thromboplastin Time KW - Parenteral Nutrition, Total KW - Vitamin K -- adverse effects KW - Vitamin K -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78182877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JPEN.+Journal+of+parenteral+and+enteral+nutrition&rft.atitle=Efficacy+and+safety+of+low-dose+intravenous+versus+intramuscular+vitamin+K+in+parenteral+nutrition+patients.&rft.au=Schepers%2C+G+P%3BDimitry%2C+A+R%3BEckhauser%2C+F+E%3BKirking%2C+D+M&rft.aulast=Schepers&rft.aufirst=G&rft.date=1988-03-01&rft.volume=12&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=JPEN.+Journal+of+parenteral+and+enteral+nutrition&rft.issn=01486071&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment response and safety of ambulatory medical detoxication. AN - 78182091; 3361908 AB - An ambulatory medical detoxication program for alcoholics with limited social and environmental supports is described. The treatment response of all 49 patients who underwent treatment and the short-term outcome and safety of 15 patients (31%) who failed to complete treatment are reviewed. Treatment completers were found to attend over 90% of their scheduled daily appointments and drinking during the treatment term was infrequent. The average duration for completed treatments was approximately 5 appointment days. Treatment noncompleters also attended their scheduled appointments regularly prior to discontinuation and, except for several patients who were transferred to inpatient treatment because of continued drinking, drinking during detoxication was relatively infrequent. The short-term outcome and safety of treatment noncompleters was reviewed. No instance of serious medical or psychiatric consequences following discontinuation from treatment was revealed. It was concluded that discontinuation of treatment by a patient is not in all cases indicative of a poor outcome. It was further concluded that ambulatory medical detoxication is a relatively successful treatment for mild to moderate alcohol withdrawal symptomatology and for patients not requiring immediate medical or psychiatric attention. JF - Journal of studies on alcohol AU - Alterman, A I AU - Hayashida, M AU - O'Brien, C P AD - Department of Psychiatry, Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 160 EP - 166 VL - 49 IS - 2 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Patient Compliance KW - Humans KW - Adult KW - Social Support KW - Follow-Up Studies KW - Male KW - Social Environment KW - Alcoholism -- rehabilitation KW - Safety KW - Ambulatory Care -- standards KW - Accident Prevention KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78182091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Treatment+response+and+safety+of+ambulatory+medical+detoxication.&rft.au=Alterman%2C+A+I%3BHayashida%2C+M%3BO%27Brien%2C+C+P&rft.aulast=Alterman&rft.aufirst=A&rft.date=1988-03-01&rft.volume=49&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of type of aftercare follow-up on treatment outcome among alcoholics. AN - 78182038; 2834605 AB - Past research on methods for actively engaging alcoholics in aftercare has been mixed with respect to the effects of such efforts on treatment outcome. The present study examined whether active follow-up methods do aid in engaging the alcoholic in treatment, whether such procedures improve treatment outcome and how much responsibility the therapist must be willing to assume in order to maintain the patient in treatment. Appointment keeping was significantly improved by a home-visit follow-up method in the first 6 months postdischarge (p less than .01). However, there was no one-to-one correspondence between improved therapy attendance and improved treatment outcome. When subjects were classified into treatment dropout and treatment completion groups, however, a treatment effect was achieved. The most intensive follow-up condition increased the probability of treatment completion, supporting to some degree the utility of aggressive follow-up. However, it was concluded that the cost of such procedures probably will limit their use since a significant economic variable (number of days hospitalized during the follow-up year) was not affected by type of aftercare. JF - Journal of studies on alcohol AU - Gilbert, F S AD - Sepulveda Veterans Administration Medical Center, California 91343. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 149 EP - 159 VL - 49 IS - 2 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Patient Compliance KW - Social Adjustment KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Alcoholism -- rehabilitation KW - Aftercare -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78182038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=The+effect+of+type+of+aftercare+follow-up+on+treatment+outcome+among+alcoholics.&rft.au=Gilbert%2C+F+S&rft.aulast=Gilbert&rft.aufirst=F&rft.date=1988-03-01&rft.volume=49&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral impairments, brain lesions and monoaminergic activity in the rat following recovery from a bout of thiamine deficiency. AN - 78181507; 2896002 AB - Learning impairments were measured in rats following recovery from a subacute bout of thiamine deficiency. Behavioral training was carried out in an automated T-maze, beginning with paired run spatial delayed non-matching to sample (PR-1), then light-dark discrimination (LD), light-dark discrimination reversal (LD-R), spatial discrimination (SD), spatial discrimination-reversal (SD-R), and finally retraining on the original paired run task (PR-2). Comparable deficits were observed for PR-1 and PR-2, thus demonstrating long-lasting impairment on delayed non-matching to sample. Experimentals performed as well as controls on LD and LD-R. Two experimental animals were unable to perform above chance on the simple SD task. The remaining 15 experimental animals were equivalent to controls on several measures of SD and SD-R performance (errors to criterion, number of animals reaching criterion, correct responses in last 60 trials) although they were significantly worse than controls on both PR-1 and PR-2. Taken together, these results indicate an impairment of representational memory (PR-1, PR-2) with a spared capacity for dispositional memory (LD, LD-R, SD, SD-R) as defined by Thomas and Spafford (Behav. Neurosci., 1984, 98: 394-404). Histological analyses of left hemispheres revealed a high incidence (94%) of thalamic lesions, specifically within the intralaminar nuclei and ventral parts of the mediodorsal nucleus; and an absence of detectable changes in other structures, including the mammillary bodies, hippocampus, cortex, and locus coeruleus. In the right hemispheres, assays of monoamines and metabolites in 17 brain regions showed significant reduction only for norepinephrine in entorhinal cortex. All animals that were selectively impaired on the paired-run task had both the medial thalamic lesions and reduction in entorhinal norepinephrine. JF - Behavioural brain research AU - Mair, R G AU - Anderson, C D AU - Langlais, P J AU - McEntee, W J AD - Research Service, Veterans Administration Medical Center, Brockton, MA 02401. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 223 EP - 239 VL - 27 IS - 3 SN - 0166-4328, 0166-4328 KW - Neurotransmitter Agents KW - 0 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Discrimination Learning -- physiology KW - Space Perception -- physiology KW - Thalamus -- pathology KW - Alcohol Amnestic Disorder -- psychology KW - Norepinephrine -- analysis KW - Male KW - Neurotransmitter Agents -- analysis KW - Brain Chemistry KW - Brain -- pathology KW - Memory -- physiology KW - Thiamine Deficiency -- psychology KW - Thiamine Deficiency -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78181507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Behavioral+impairments%2C+brain+lesions+and+monoaminergic+activity+in+the+rat+following+recovery+from+a+bout+of+thiamine+deficiency.&rft.au=Mair%2C+R+G%3BAnderson%2C+C+D%3BLanglais%2C+P+J%3BMcEntee%2C+W+J&rft.aulast=Mair&rft.aufirst=R&rft.date=1988-03-01&rft.volume=27&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Activation peaking in intoxicated and detoxified alcoholics during visuospatial learning. AN - 78177147; 3361904 AB - Physiologic activation response patterning, termed activation peaking, and visuospatial learning performance were examined to understand the effects of chronic alcohol use on complex information processing. A total of 18 alcoholic male inpatients in an alcoholism treatment unit served as participants. Nine persons were seen while intoxicated (mean blood alcohol level [BAL] = 18.0mg/dl) at time of admission to the unit. The second group of nine persons were seen detoxified after 4 weeks in the treatment unit (BAL = 0 mg/dl). Skin conductance and heart rate were measured before and during learning. Learning consisted of a paired-associate paradigm requiring participants to learn the distinct spatial positions of six randomly presented "nonsense" shapes. The visuospatial learning of the intoxicated alcoholics was superior to that of the detoxified alcoholics. The physiological patterning of intoxicated alcoholics clearly and correctly tracked their learning performance, while the detoxified alcoholics displayed no clear pattern. The results indicated that the detoxified alcoholic may suffer a disruption in attentional mechanisms related to visuospatial information processing, providing support for theory that alcohol ingestion may serve to balance information processing in the alcoholic. JF - Journal of studies on alcohol AU - Schandler, S L AU - Cohen, M J AU - McArthur, D L AU - Naliboff, B D AU - Hassell, A AD - Addiction Research Laboratory, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 126 EP - 130 VL - 49 IS - 2 SN - 0096-882X, 0096-882X KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Pattern Recognition, Visual -- drug effects KW - Ethanol -- blood KW - Paired-Associate Learning -- drug effects KW - Humans KW - Adult KW - Orientation -- drug effects KW - Middle Aged KW - Attention -- drug effects KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholic Intoxication -- psychology KW - Psychomotor Performance -- drug effects KW - Arousal -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78177147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Activation+peaking+in+intoxicated+and+detoxified+alcoholics+during+visuospatial+learning.&rft.au=Schandler%2C+S+L%3BCohen%2C+M+J%3BMcArthur%2C+D+L%3BNaliboff%2C+B+D%3BHassell%2C+A&rft.aulast=Schandler&rft.aufirst=S&rft.date=1988-03-01&rft.volume=49&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Serum albumin. AN - 78166938; 3281888 AB - The liver manufactures albumin at a massive rate and decreases production in times of environmental, nutritional, toxic and trauma stress. Osmotic pressure is a basic evolutionary regulatory factor, and hormonal control over albumin production has been demonstrated. Where and why new or old albumin is degraded are questions which have not been clarified, although the vascular endothelium may well be the degradative site. Albumin is important as a transport protein, as a measure of evolution and as a model to study secretion following synthesis without the intervening steps of glycosylation. Investigations as to how this protein enters the endoplasmic membrane may well answer some of the questions concerning signal peptide insertion (288). The role of the urea cycle intermediate ornithine and its participation in polyamine synthesis, which has a positive effect on albumin synthesis, is under study. Likewise, the inverse relation between acute-phase protein synthesis and albumin synthesis regulated by interleukin 1 and other cytokines will merit further study. These are a few of the concepts which will be tested in the future. JF - Hepatology (Baltimore, Md.) AU - Rothschild, M A AU - Oratz, M AU - Schreiber, S S AD - Nuclear Medicine Service, Veterans Administration Medical Center, New York, New York 10010. PY - 1988 SP - 385 EP - 401 VL - 8 IS - 2 SN - 0270-9139, 0270-9139 KW - Hormones KW - 0 KW - Serum Albumin KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Genetic Variation KW - Disease -- blood KW - Animals KW - Animal Nutritional Physiological Phenomena KW - Chemistry KW - Hormones -- physiology KW - Ethanol -- pharmacology KW - Humans KW - Chemical Phenomena KW - Temperature KW - Liver Cirrhosis, Experimental -- metabolism KW - Intracellular Membranes -- metabolism KW - Stress, Physiological -- blood KW - Aging -- blood KW - Serum Albumin -- therapeutic use KW - Serum Albumin -- physiology KW - Serum Albumin -- metabolism KW - Serum Albumin -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78166938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Serum+albumin.&rft.au=Rothschild%2C+M+A%3BOratz%2C+M%3BSchreiber%2C+S+S&rft.aulast=Rothschild&rft.aufirst=M&rft.date=1988-03-01&rft.volume=8&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-23 N1 - Date created - 1988-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A phorbol ester tolerant (PET) variant of HL-60 promyelocytes. AN - 78163570; 3162684 AB - The promyelocytic leukaemia cell line HL-60 differentiates to a macrophage-like cell when exposed to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and other agents which activate protein kinase C. To investigate this phenomenon we developed an HL-60 variant which does not differentiate when exposed to TPA. HL-60 cells were exposed to the mutagen ethyl methanesulphonate and were cloned in soft agar in the presence of a normally lethal concentration of TPA. One colony of cells that proliferated in TPA was obtained. The cells of this phorbol ester tolerant (PET) line have retained their resistance to TPA for several years without selective pressure. They are somewhat larger than their phorbol ester sensitive (S) parent, but they are otherwise morphologically similar. When PET-cells are exposed to TPA their growth is arrested for approximately 48 h. Thereafter, they resume their original rate of replication at all concentrations of TPA tested. S-cells undergo changes typical of HL-60 when exposed to TPA; they aggregate, stop growing, adhere to the flask and die. The PET-cells appeared to be as sensitive as S-cells to other agents which differentiate HL-60 such as retinoic acid, dimethysulphoxide, and 1,25-dihydroxyvitamin D3, as determined by rate of proliferation in culture, Wright's stain, nitroblue tetrazolium reduction, and induction of the ectoenzyme NAD-glycohydrolase. TPA-induced protein phosphorylation was studied using one- and two-dimensional polyacrylamide gel electrophoresis. Several proteins increased their incorporation of 32P when S- and PET-cells were exposed to TPA, the most prominent of which were the two previously described nuclear matrix proteins of 80 kd and 33 kd. There was no difference in the protein phosphorylation pattern in S- and PET-cells, nor in how this pattern changed on TPA exposure. Fluorescent activated cell sorting and karyotypic analysis revealed PET-cells to be a hypotetraploid variant of S-cells, with approximately 80 chromosomes, including a marker chromosome iso(1p) not found in the S-cells. Identification of the biochemical lesion responsible for this TPA resistance in PET cells will provide clues concerning the mechanism of this important pathway for the induction of cell differentiation. JF - British journal of haematology AU - Macfarlane, D E AU - Gailani, D AU - Vann, K AD - Department of Medicine, Veterans Administration Hospital, Iowa City, Iowa. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 291 EP - 302 VL - 68 IS - 3 SN - 0007-1048, 0007-1048 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Karyotyping KW - Genetic Variation KW - Drug Tolerance KW - Microscopy, Electron KW - Cell Differentiation -- drug effects KW - Time Factors KW - Cell Line KW - Tumor Cells, Cultured -- drug effects KW - Leukemia, Myeloid, Acute -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Leukemia, Myeloid, Acute -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78163570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=A+phorbol+ester+tolerant+%28PET%29+variant+of+HL-60+promyelocytes.&rft.au=Macfarlane%2C+D+E%3BGailani%2C+D%3BVann%2C+K&rft.aulast=Macfarlane&rft.aufirst=D&rft.date=1988-03-01&rft.volume=68&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=00071048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-18 N1 - Date created - 1988-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Early diagnosis of overwhelming Vibrio vulnificus infections. AN - 78135224; 3347871 JF - Southern medical journal AU - Eng, R H AU - Chmel, H AU - Smith, S M AU - Haacker, D AU - Grigoriu, A AD - Medical Service, Veterans Administration Medical Center, East Orange, NJ 07019. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 410 EP - 411 VL - 81 IS - 3 SN - 0038-4348, 0038-4348 KW - Tetracycline KW - F8VB5M810T KW - Abridged Index Medicus KW - Index Medicus KW - Tetracycline -- therapeutic use KW - Punctures -- adverse effects KW - Animals KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Vibrio -- isolation & purification KW - Plants -- microbiology KW - Vibrio Infections -- pathology KW - Fishes KW - Leg Injuries -- etiology KW - Food Contamination KW - Vibrio Infections -- drug therapy KW - Vibrio Infections -- diagnosis KW - Leg Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78135224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Early+diagnosis+of+overwhelming+Vibrio+vulnificus+infections.&rft.au=Eng%2C+R+H%3BChmel%2C+H%3BSmith%2C+S+M%3BHaacker%2C+D%3BGrigoriu%2C+A&rft.aulast=Eng&rft.aufirst=R&rft.date=1988-03-01&rft.volume=81&rft.issue=3&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence that diminished pituitary responsivity to GHRF is secondary to intracellular GH pool depletion. AN - 78131885; 3126669 AB - In a perifused dispersed rat anterior pituitary cell system, growth hormone (GH) secretion became attenuated in response to repeated pulsatile or prolonged exposure to submaximal stimulatory concentrations of rat growth hormone-releasing factor (GHRF). However, persistent intracellular GH stores could be released upon subsequent challenge with the membrane depolarizing agent KCl, forskolin, or the phorbol ester, tetradecanoylphorbol acetate (TPA). The GH secretory response to repeated pulsatile administration of either KCl or forskolin also became attenuated. In these experiments, persistent intracellular GH stores could be released upon subsequent GHRF stimulation. Repeated challenge with pulses of TPA failed to elicit any GH release after the initial stimulatory response, although a subsequent GHRF pulse was stimulatory, indicating persistence of intracellular GH stores. These data are compatible with the hypothesis that the decreased GH secretory responsivity to GHRF, which was observed in the course of these experiments, is caused by the functional depletion of specific secretagogue-sensitive pools of intracellular GH, rather than by receptor-mediated desensitization. JF - The American journal of physiology AU - Richardson, S B AU - Twente, S AD - Department of Medicine, Veterans Administration Medical Center, New York, New York. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - E358 EP - E364 VL - 254 IS - 3 Pt 1 SN - 0002-9513, 0002-9513 KW - Colforsin KW - 1F7A44V6OU KW - Potassium Chloride KW - 660YQ98I10 KW - Growth Hormone KW - 9002-72-6 KW - Growth Hormone-Releasing Hormone KW - 9034-39-3 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Osmolar Concentration KW - Calcium -- metabolism KW - Animals KW - Colforsin -- pharmacology KW - Extracellular Space -- metabolism KW - Potassium Chloride -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Intracellular Membranes -- metabolism KW - Male KW - Growth Hormone-Releasing Hormone -- pharmacology KW - Pituitary Gland -- cytology KW - Pituitary Gland -- metabolism KW - Growth Hormone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78131885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Evidence+that+diminished+pituitary+responsivity+to+GHRF+is+secondary+to+intracellular+GH+pool+depletion.&rft.au=Richardson%2C+S+B%3BTwente%2C+S&rft.aulast=Richardson&rft.aufirst=S&rft.date=1988-03-01&rft.volume=254&rft.issue=3+Pt+1&rft.spage=E358&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of DNA methylase activity by acrolein. AN - 78125897; 3345585 AB - Acrolein, a reactive metabolite of cyclophosphamide, may be responsible for bladder cancer induced by cyclophosphamide. DNA methylase was isolated from the liver and urothelium of rats by high salt extraction of purified nuclei. Acrolein at 10 microM inhibited liver and bladder DNA methylase activity by 30-50%. Kinetic studies with the liver enzyme showed a competitive type of inhibition with a Ki of 6.7 microM. Both dithiothreitol and glutathione afforded protection to the enzyme when added to the assay. At near equimolar concentrations of glutathione to acrolein, the methylase retained 80-90% activity. An increase in DNA had no effect on the inhibition by acrolein, whereas increased amounts of protein protected against acrolein inhibition, suggesting that acrolein reacted with the DNA methylase protein. On the other hand, DNA that had been reacted with acrolein was unable to serve as a substrate for DNA methylase. As the DNA adducts increased the methylation of the DNA decreased. Thus, acrolein has the ability to react with DNA and the DNA methylase protein, either of which results in inhibition of DNA methylation. JF - Carcinogenesis AU - Cox, R AU - Goorha, S AU - Irving, C C AD - Cancer Research Laboratory, Veterans Administration Medical Center, Memphis, TN. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 463 EP - 465 VL - 9 IS - 3 SN - 0143-3334, 0143-3334 KW - Aldehydes KW - 0 KW - Acrolein KW - 7864XYD3JJ KW - DNA KW - 9007-49-2 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - Dithiothreitol KW - T8ID5YZU6Y KW - Index Medicus KW - DNA -- metabolism KW - Dithiothreitol -- pharmacology KW - Methylation KW - Acrolein -- pharmacology KW - DNA (Cytosine-5-)-Methyltransferase -- antagonists & inhibitors KW - Aldehydes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78125897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+DNA+methylase+activity+by+acrolein.&rft.au=Cox%2C+R%3BGoorha%2C+S%3BIrving%2C+C+C&rft.aulast=Cox&rft.aufirst=R&rft.date=1988-03-01&rft.volume=9&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of pindolol administration on serum levels of thioridazine, haloperidol, phenytoin, and phenobarbital. AN - 78125042; 3346197 AB - Twenty-six male patients with intermittent explosive disorder secondary to organic brain disease were studied. Each had been treated with long-term administration of thioridazine, haloperidol, phenytoin, and/or phenobarbital, either singly or in combination. The effect of adding increasing doses of pindolol--a beta-adrenergic blocking agent previously demonstrated to be effective in the treatment of intermittent explosive disorder--on serum levels of each long-term medication was determined. Moderate, dose-related increases in serum levels of thioridazine and two of its metabolites were found when pindolol was added. Conversely, higher-than-expected serum pindolol levels occurred in patients receiving thioridazine. No serum level increases were found for haloperidol, phenytoin, or phenobarbital when pindolol was added to each of these drugs individually, but serum phenytoin levels did rise in two patients receiving all three drugs simultaneously when pindolol was added. Three treatment failures with pindolol occurred in association with low serum pindolol levels. JF - The Journal of clinical psychiatry AU - Greendyke, R M AU - Gulya, A AD - Neurobehavioral Intensive Care Unit, Veterans Administration Medical Center, Canandaigua, NY 14424. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 105 EP - 107 VL - 49 IS - 3 SN - 0160-6689, 0160-6689 KW - Phenytoin KW - 6158TKW0C5 KW - Pindolol KW - BJ4HF6IU1D KW - Haloperidol KW - J6292F8L3D KW - Thioridazine KW - N3D6TG58NI KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Drug Therapy, Combination KW - Rage -- drug effects KW - Drug Interactions KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Phenobarbital -- blood KW - Pindolol -- therapeutic use KW - Neurocognitive Disorders -- blood KW - Pindolol -- blood KW - Haloperidol -- blood KW - Pindolol -- pharmacology KW - Phenytoin -- blood KW - Thioridazine -- blood KW - Neurocognitive Disorders -- drug therapy KW - Violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78125042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Effect+of+pindolol+administration+on+serum+levels+of+thioridazine%2C+haloperidol%2C+phenytoin%2C+and+phenobarbital.&rft.au=Greendyke%2C+R+M%3BGulya%2C+A&rft.aulast=Greendyke&rft.aufirst=R&rft.date=1988-03-01&rft.volume=49&rft.issue=3&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Concomitant administration of terazosin and atenolol for the treatment of essential hypertension. AN - 78114200; 3277569 AB - The safety and efficacy of once-daily terazosin hydrochloride administered concomitantly with once-daily atenolol for the treatment of essential hypertension were evaluated in this double-blind, multiclinic, placebo-controlled study. After each patient received 50 mg of atenolol daily for eight weeks, patients with a supine diastolic blood pressure (DBP) of 95 to 110 mm Hg and whose supine DBP had decreased at least 5 mm Hg were randomized to receive either terazosin (plus atenolol) or placebo (plus atenolol) for ten weeks. Patients assigned to the terazosin hydrochloride treatment group received increasing dosages (1,2,5, and 10 mg daily) [corrected] of terazosin at two-week intervals until the maximum dose was reached or until the supine DBP was decreased to less than 90 mm Hg. Terazosin-treated patients (n = 43) had significant mean decreases from the baseline in supine BP (systolic/diastolic = -8.8/-8.5 mm Hg) and standing BP (-10.9/-9.5 mm Hg), whereas the decreases in BP in the placebo-treated patients (n = 49; supine, -2.3/-2.6 mm Hg; standing, -1.4/-1.3 mm Hg) were not significant. When terazosin and placebo were compared, the differences in BP were significant. Terazosin-treated patients had significantly greater decreases in mean percent change of total cholesterol (-4.8%) and low-density lipoprotein plus very-low-density lipoprotein cholesterol (-6.3%) levels, compared with the placebo-treated patients (+0.6% and +1.1%, respectively). Concomitant administration of terazosin and atenolol to patients with essential hypertension was found to be safe and efficacious. JF - Archives of internal medicine AU - Holtzman, J L AU - Kaihlanen, P M AU - Rider, J A AU - Lewin, A J AU - Spindler, J S AU - Oberlin, J A AD - Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 539 EP - 543 VL - 148 IS - 3 SN - 0003-9926, 0003-9926 KW - Atenolol KW - 50VV3VW0TI KW - Terazosin KW - 8L5014XET7 KW - Prazosin KW - XM03YJ541D KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Evaluation KW - Drug Administration Schedule KW - Double-Blind Method KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Male KW - Female KW - Prazosin -- adverse effects KW - Prazosin -- analogs & derivatives KW - Atenolol -- therapeutic use KW - Atenolol -- adverse effects KW - Prazosin -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78114200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Concomitant+administration+of+terazosin+and+atenolol+for+the+treatment+of+essential+hypertension.&rft.au=Holtzman%2C+J+L%3BKaihlanen%2C+P+M%3BRider%2C+J+A%3BLewin%2C+A+J%3BSpindler%2C+J+S%3BOberlin%2C+J+A&rft.aulast=Holtzman&rft.aufirst=J&rft.date=1988-03-01&rft.volume=148&rft.issue=3&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Arch Intern Med 1988 Sep;148(9):1960 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Patterns of familial alcoholism, alcoholism severity, and psychopathology. AN - 78107527; 3343590 AB - The interrelationships among the severity of alcoholism, psychopathology/personality, and the degree of familial alcoholism were examined using the following four familial alcoholism classification schemes, which each differentiated three degrees of familial alcoholism: 1) conventional, compared alcoholics with no, nonparental, and parental alcoholic relatives; 2) lineality, distinguished between subgroups with alcoholism in neither, one, or both sides of their family; 3) generational, compared alcoholics having no, one, or two generations of familial alcoholism; 4) quantitative, credited one point for each first-degree and 1/2 point for each second-degree alcoholic relative. The subjects were 83 male alcoholic Veterans Administration inpatients 50 years of age or under. The Alcohol Use Inventory, various alcohol-related symptoms and behaviors, and laboratory values were used to evaluate the severity/pattern of alcoholism. Psychopathology/personality were measured by the MMPI, the Psychopathic State Inventory, the MacAndrew Alcoholism Scale, the Childhood Problem Behaviors Questionnaire, and the percentage of patients with an antisocial personality disorder (ASP) diagnosis. Surprisingly few subgroup differences were revealed in the severity/pattern of alcoholism. Only age at time of treatment and use of nonalcoholic drugs were associated with increasing familial alcoholism. On the other hand, childhood behavior problems, particularly antisocial behavior, and an ASP diagnosis were found to be associated with an increasing degree of familial alcoholism. The diagnosis of ASP was most apparent in the two-generational and bilineal alcoholics, while an increased degree of familial alcoholism was not associated with ASP for the conventional classification. Bilineal familial alcoholics also exhibited an MMPI profile reflective of a characterological disorder.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of nervous and mental disease AU - Alterman, A I AD - Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 167 EP - 175 VL - 176 IS - 3 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Psychiatric Status Rating Scales KW - Humans KW - MMPI KW - Adult KW - Personality Inventory KW - Middle Aged KW - Male KW - Manuals as Topic KW - Alcoholism -- diagnosis KW - Alcoholism -- classification KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78107527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Patterns+of+familial+alcoholism%2C+alcoholism+severity%2C+and+psychopathology.&rft.au=Alterman%2C+A+I&rft.aulast=Alterman&rft.aufirst=A&rft.date=1988-03-01&rft.volume=176&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-06 N1 - Date created - 1988-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pericardial effusion and left ventricular dysfunction associated with ascites secondary to hepatic cirrhosis. AN - 78105062; 3341860 AB - Fluid retention in decompensated hepatic cirrhosis is frequently accompanied by edema, ascites, and hydrothorax. Whether pericardial effusion occurs in such patients has not been studied. Twenty-seven consecutively hospitalized patients with ascites secondary to alcoholic cirrhosis of the liver were studied, and 28 control subjects were studied with the use of an echocardiographic method to detect pericardial effusion and to evaluate their left ventricular (LV) function. Seventeen patients (63%) and three control subjects (11%) showed pericardial effusion. The prevalence of pericardial effusion in the patients was significantly greater than in the control subjects (chi 2 = 10.6). Although the mean values of the echocardiographic measurements of LV function of the patients and the control subjects did not differ significantly, the individual values of the patients varied considerably. Among the patients, six patients (27%) had LV dysfunction, 14 patients (64%) had normal values, and two patients (9%) had values suggestive of hypercontractility of the left ventricle. Furthermore, abnormal systolic motions of the mitral valve and/or septum were noted in eight patients (30%) but in none of the control subjects. Six patients with pericardial effusion on initial examination were evaluated after the resolution of their ascites; pericardial effusion disappeared in two patients, diminished in two others, and remained unchanged in two patients. Resolution of ascites was also associated with normalization of the systolic motion of the mitral valve and septum. It was concluded that pericardial effusion is common in patients with ascites secondary to alcoholic hepatic cirrhosis and that its presence is probably related to fluid retention. JF - Archives of internal medicine AU - Shah, A AU - Variyam, E AD - Department of Medicine, Veterans Administration Medical Center, Cleveland, OH 44106. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 585 EP - 588 VL - 148 IS - 3 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Heart Ventricles -- physiopathology KW - Male KW - Female KW - Liver Cirrhosis, Alcoholic -- complications KW - Pericardial Effusion -- etiology KW - Ascites -- etiology KW - Ascites -- complications KW - Myocardial Contraction KW - Liver Cirrhosis, Alcoholic -- physiopathology KW - Echocardiography KW - Pericardial Effusion -- physiopathology KW - Ascites -- physiopathology KW - Pericardial Effusion -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78105062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Pericardial+effusion+and+left+ventricular+dysfunction+associated+with+ascites+secondary+to+hepatic+cirrhosis.&rft.au=Shah%2C+A%3BVariyam%2C+E&rft.aulast=Shah&rft.aufirst=A&rft.date=1988-03-01&rft.volume=148&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 1991 Apr;151(4):816 [1772478] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 19-Nordeoxycorticosterone excretion in male and female inbred salt-sensitive (S/JR) and salt-resistant (R/JR) Dahl rats. AN - 78102950; 3342746 AB - Rats were selectively bred for susceptibility (S) and resistance (R) to the hypertensinogenic effects of excess salt intake by Dahl and further inbred to virtual homozygosity by Rapp (S/JR and R/JR). The S strain has been shown to have a mutation of the cytochrome P-450-dependent 11 beta,18-hydroxylase resulting in the enhanced production of 18-hydroxydeoxycorticosterone (18-OH-DOC) compared to that of the R strain. It is known that this enzyme is also responsible for the hydroxylation of deoxycorticosterone at the 19 position to produce 19-hydroxydeoxycorticosterone. Recently, the excretion of 19-nordeoxycorticosterone (19-nor-DOC), a potent mineralocorticoid, has been shown to be markedly increased in S/JR females compared to that in R/JR females consuming a high sodium diet. While the S/JR rat is spontaneously hypertensive, the course of the disease is greatly accelerated and exacerbated by a high sodium diet. If, indeed, 19-nor-DOC is responsible for the spontaneous hypertension in the S/JR rat, then its production should also be higher in the S/JR rat consuming a normal salt diet. Furthermore, since its production is suppressed by NaCl intake, the excretion should be even higher when not suppressed by a high sodium diet. We measured the urinary excretion of 19-nor-DOC, 18-OH-DOC, and corticosterone in male and female S/JR and R/JR rats consuming a normal sodium diet. The excretions of corticosterone and 18-OH-DOC were significantly higher by S/JR of both sexes than by R/JR, with the excretion by female rats being higher than that by male rats within the same strain. The hierarchy of excretion rates of 19-nor-DOC was: S/JR females greater than R/JR females greater than S/JR males greater than R/JR male rats. These studies indicate that while S/JR rats of both sexes develop higher blood pressures than the R/JR even on a standard salt intake, the excretion of 19-nor-DOC does not correlate well with their blood pressure elevation, since the normotensive female R/JR rat excretes significantly higher quantities of 19-nor-DOC than the hypertensive male S/JR rat. Thus, it is unclear whether 19-nor-DOC is playing a significant role in the pathogenesis of the hypertension in the S/JR rat. It also remains unknown whether the renal site of formation of 19-nor-DOC allows access to the mineralocorticoid target sites in the kidney. JF - Endocrinology AU - Gomez-Sanchez, E P AU - Gomez-Sanchez, C E AD - Research Service, James A. Haley Veterans Administration Medical Center, Tampa, Florida 33612. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 1110 EP - 1113 VL - 122 IS - 3 SN - 0013-7227, 0013-7227 KW - Sodium, Dietary KW - 0 KW - 18-hydroxydeoxycorticosterone KW - 379-68-0 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - 19-nordeoxycorticosterone KW - 4682-70-6 KW - Corticosterone KW - W980KJ009P KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred SHR KW - Blood Pressure KW - Sex Characteristics KW - Corticosterone -- urine KW - Male KW - Female KW - Hypertension -- urine KW - Hypertension -- chemically induced KW - Sodium, Dietary -- adverse effects KW - Sodium, Dietary -- administration & dosage KW - Hypertension -- genetics KW - Desoxycorticosterone -- urine KW - Desoxycorticosterone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78102950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=19-Nordeoxycorticosterone+excretion+in+male+and+female+inbred+salt-sensitive+%28S%2FJR%29+and+salt-resistant+%28R%2FJR%29+Dahl+rats.&rft.au=Gomez-Sanchez%2C+E+P%3BGomez-Sanchez%2C+C+E&rft.aulast=Gomez-Sanchez&rft.aufirst=E&rft.date=1988-03-01&rft.volume=122&rft.issue=3&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-06 N1 - Date created - 1988-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neutrophil adherence to human endothelial cells. AN - 78099416; 3343543 AB - These studies evaluated whether the increased adherence of neutrophils to endothelium after exposure to lipopolysaccharide (LPS) endotoxin is primarily an effect on neutrophils or on endothelial cells. The studies demonstrate that preincubation of monolayers of human umbilical vein endothelial cells with LPS has a significantly greater effect on neutrophil adherence to endothelium than does preincubation of neutrophils with LPS (P less than 0.001 for each amount of LPS). Although the effect was small compared with incubation of endothelial cells with LPS, incubation of neutrophils with LPS did significantly increase their subsequent adherence to endothelial cells compared with controls (P less than 0.05). LPS was not toxic to either endothelial cells or neutrophils, as measured by the release of lactate dehydrogenase. Preincubation of endothelial cells with LPS at a concentration of 1.0 to 10 micrograms/ml maximally increased their ability to bind to neutrophils, and this effect was maximally expressed after 4 hours of exposure to LPS. In the assay, neutrophil binding to LPS-stimulated endothelial cells was rapid and did not increase after 30 minutes of coculture of neutrophils and endothelium. Morphologic studies demonstrated that LPS opened cell-to-cell junctions between endothelial cells. Neutrophils that attached to these monolayers of LPS-stimulated endothelial cells bound, primarily, to the margins of the endothelial cells and not to the underlying tissue culture dishes, which were exposed after incubation with LPS. These observations suggest that LPS increases neutrophil adherence primarily, but not solely, via an effect on endothelial cells. JF - The Journal of laboratory and clinical medicine AU - Thomas, P D AU - Hampson, F W AU - Casale, J M AU - Hunninghake, G W AD - Department of Medicine, Veterans Administration, Iowa City, IA. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 286 EP - 292 VL - 111 IS - 3 SN - 0022-2143, 0022-2143 KW - Lipopolysaccharides KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Cells, Cultured KW - Lipopolysaccharides -- pharmacology KW - Kinetics KW - Humans KW - Cell Adhesion -- drug effects KW - Microscopy, Electron, Scanning KW - Neutrophils -- ultrastructure KW - Neutrophils -- physiology KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78099416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Neutrophil+adherence+to+human+endothelial+cells.&rft.au=Thomas%2C+P+D%3BHampson%2C+F+W%3BCasale%2C+J+M%3BHunninghake%2C+G+W&rft.aulast=Thomas&rft.aufirst=P&rft.date=1988-03-01&rft.volume=111&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sustained increase in the proliferation of rat colonic mucosa during chronic treatment with aspirin. AN - 78096800; 3123301 AB - The effects of indomethacin and aspirin on colonic epithelial proliferative activity, colonic prostaglandin synthesis, and colonic mucosal cyclic adenosine 3',5'-monophosphate content were examined. Administration of indomethacin (3 mg/kg.day, s.c.) for 2 wk suppressed ex vivo colonic prostaglandin E2 production by 50% and increased [3H]thymidine incorporation into mucosal DNA in vivo, but induced colonic inflammation. Higher doses of indomethacin were toxic and associated with high mortality. By contrast, administration of aspirin (50 mg/kg.day, s.c.) for 2-20 wk suppressed colonic prostaglandin E2 production by 97% and was unassociated with colonic inflammation or systemic toxicity. Suppression of colonic prostaglandin E2 production was associated with a sustained stimulation of [3H]thymidine incorporation into colonic mucosal deoxyribonucleic acid (2-20 wk) and an increase in the [3H]thymidine labeling index when examined at 20 wk. Basal cyclic adenosine 3',5'-monophosphate content of colonic mucosa was markedly reduced in aspirin-treated rats. Moreover, addition of dimethyl prostaglandin E2 or 8-Br-cyclic adenosine 3',5'-monophosphate suppressed the elevated levels of [3H]thymidine incorporation into mucosal deoxyribonucleic acid in incubated colonic segments from aspirin-treated rats. The results demonstrate that sustained suppression of colonic prostaglandin synthesis by aspirin is associated with a persistent increase in colonic epithelial proliferative activity. They support a role for local colonic prostaglandin synthesis as a negative modulator of epithelial growth, possibly mediated through increases in colonic mucosal cyclic adenosine 3',5'-monophosphate. JF - Gastroenterology AU - Craven, P A AU - Thornburg, K AU - DeRubertis, F R AD - Department of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 567 EP - 575 VL - 94 IS - 3 SN - 0016-5085, 0016-5085 KW - Prostaglandins E KW - 0 KW - DNA KW - 9007-49-2 KW - Lipoxygenase KW - EC 1.13.11.12 KW - Dinoprostone KW - K7Q1JQR04M KW - Aspirin KW - R16CO5Y76E KW - Thymidine KW - VC2W18DGKR KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Thymidine -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Lipoxygenase -- metabolism KW - Prostaglandins E -- biosynthesis KW - DNA -- biosynthesis KW - Female KW - Epithelium -- drug effects KW - Intestinal Mucosa -- physiology KW - Colon -- metabolism KW - Colon -- drug effects KW - Cell Division -- drug effects KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects KW - Colon -- physiology KW - Aspirin -- pharmacology KW - Indomethacin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Sustained+increase+in+the+proliferation+of+rat+colonic+mucosa+during+chronic+treatment+with+aspirin.&rft.au=Craven%2C+P+A%3BThornburg%2C+K%3BDeRubertis%2C+F+R&rft.aulast=Craven&rft.aufirst=P&rft.date=1988-03-01&rft.volume=94&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-11 N1 - Date created - 1988-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - "Combat Addiction" Post-Traumatic Stress Disorder Re-Explored AN - 61569876; 198802282 AB - An examination of 1986 interview data collected from Vietnam War combat veterans (N = 22) diagnosed as posttraumatic stress disorder sufferers at the Augusta, Ga, Veterans Administration Medical Center, focusing on combat recall in nightmares & "flashbacks" as being exciting & powerful. Other indicators of a mutually reinforcing series of subjectively & physiologically excitatory processes that might contribute to symptom maintenance are also examined. Findings indicate the clear history of combat, killing, & flashback or nightmare recall as excitatory, similar to an adrenergic rush, in 86.4% of the Rs. Implications of this & other behavioral indicators of "combat addiction" are explored with respect to meaning & treatment difficulties. 3 Tables, 20 References. Modified HA JF - Psychiatric Journal of the University of Ottawa/Revue de Psychiatrie de l'Universite d'Ottawa AU - Solursh, Lionel AD - Veterans Administration Medical Center, Augusta GA 30910 Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 17 EP - 20 VL - 13 IS - 1 KW - combat addiction/recall, Vietnam War veterans, Georgia KW - interviews KW - 1985 KW - Psychological Stress KW - Veterans KW - Vietnam War KW - Combat KW - Psychopathology KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61569876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Journal+of+the+University+of+Ottawa%2FRevue+de+Psychiatrie+de+l%27Universite+d%27Ottawa&rft.atitle=%22Combat+Addiction%22+Post-Traumatic+Stress+Disorder+Re-Explored&rft.au=Solursh%2C+Lionel&rft.aulast=Solursh&rft.aufirst=Lionel&rft.date=1988-03-01&rft.volume=13&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Journal+of+the+University+of+Ottawa%2FRevue+de+Psychiatrie+de+l%27Universite+d%27Ottawa&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Combat; Psychopathology; Psychological Stress ER - TY - JOUR T1 - Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Actions of therapeutic agents. AN - 78142497; 2894763 AB - All nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of rheumatic diseases may cause gastric mucosal damage. Although the best-studied agent is aspirin, the mechanisms by which it damages the gastric mucosa are not fully understood. However, it is thought that the drug impairs mucosal defenses by penetrating the protective mucous and bicarbonate layers and damaging the epithelial lining cells. In turn, gastric acid is permitted to pour through the breached defenses. This "back-diffusion" of acid further injures cells and destroys capillaries and venules. This local damaging effect is pH dependent and is contributed to by the acid secretion of the stomach. Other mechanisms by which aspirin may induce or contribute to mucosal injury include inhibition of mucosal prostaglandin synthesis, reduction and alteration of mucus secretion, reduction of bicarbonate secretion, interference with cell turnover, as well as systemic effects such as platelet dysfunction. The mechanism by which nonaspirin NSAIDs cause gastrointestinal damage is uncertain. All are known to inhibit prostaglandin synthesis, which could contribute to their toxicity since prostaglandins found in the stomach both inhibit acid secretion and have mucosal defensive effects. Partial protections against aspirin-induced or other NSAID-induced gastric mucosal damage has been demonstrated, at least in some studies, by sucralfate, prostaglandins, omeprazole and histamine (H2)-receptor antagonists. Sucralfate appears to act primarily on local defensive mechanisms; its antisecretory effects are minimal. Prostaglandins exert a protective effect at both antisecretory and nonantisecretory (cytoprotective) doses, indicating that either or both mechanisms may be involved. The most recently studied agent, omeprazole, is the most potent of all acid inhibitors; it may also be cytoprotective, possibly as a result of its effects on sulfhydryl groups. Prostaglandins and omeprazole are not available in the United States and their potential side effects may limit their use in patients with chronic rheumatic diseases. Protection by H2-receptor antagonists is mostly related to reduction of acid secretion, though a cytoprotective effect may occur. JF - The American journal of medicine AU - Ivey, K J AD - Department of Medicine, Long Beach Veterans Administration Medical Center, California 90822. Y1 - 1988/02/22/ PY - 1988 DA - 1988 Feb 22 SP - 41 EP - 48 VL - 84 IS - 2A SN - 0002-9343, 0002-9343 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Histamine H2 Antagonists KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Aspirin -- adverse effects KW - Humans KW - Gastrointestinal Hemorrhage -- chemically induced KW - Histamine H2 Antagonists -- therapeutic use KW - Gastrointestinal Diseases -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- antagonists & inhibitors KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Gastrointestinal Diseases -- chemically induced KW - Gastrointestinal Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78142497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Mechanisms+of+nonsteroidal+anti-inflammatory+drug-induced+gastric+damage.+Actions+of+therapeutic+agents.&rft.au=Ivey%2C+K+J&rft.aulast=Ivey&rft.aufirst=K&rft.date=1988-02-22&rft.volume=84&rft.issue=2A&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-20 N1 - Date created - 1988-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mobilization of cellular Ca2+ by lysophospholipids in rat islets of Langerhans. AN - 78107596; 3277674 AB - To determine whether lysophospholipids mobilize cellular Ca2+, intact rat islets were prelabelled with 45Ca2+ and subjected to three maneuvers designed to simulate the physiologic accumulation of lysophospholipids: (1) exogenous provision; (2) addition of porcine pancreatic phospholipase A2; and (3) provision of p-hydroxymercuribenzoic acid, which impedes both the reacylation and hydrolysis of endogenous lysophospholipids, leading to their accumulation in islets. Each maneuver provoked 45Ca2+ efflux at concentrations nearly identical to those previously reported to induce insulin release in the absence of toxic effects on the islets. Lysophosphatidylcholine (lysoPC) and lysophosphatidylinositol were active, whereas the ethanolamine and serine derivatives, and lysophosphatidic acid, were much less effective. The effects of lysoPC were reversible; they also were reduced by lanthanum or gentamicin (which are probes of superficial, plasma membrane-bound stores of Ca2+) or by prior depletion of membrane-bound cellular Ca2+ stores using ionomycin, but not by removal of extracellular Ca2+ or Na+. The effects of lysoPC, phospholipase A2 and p-hydroxymercuribenzoic acid were largely independent of any hydrolysis to, or accumulation of, free fatty acids as assessed by resistance to dantrolene or trifluoperazine (which selectively reduce arachidonic acid-induced 45Ca2+ efflux and insulin release). Thus, lysophospholipids are a newly recognized class of lipid mediators which may promote insulin release at least in part via mobilization of a pool(s) of Ca2+ ('trigger Ca2+') bound in the plasma membrane and possibly in other cellular membranes. JF - Biochimica et biophysica acta AU - Metz, S A AD - Research Service, Denver Veterans Administration Medical Center, CO. Y1 - 1988/02/22/ PY - 1988 DA - 1988 Feb 22 SP - 239 EP - 252 VL - 968 IS - 2 SN - 0006-3002, 0006-3002 KW - Ethers KW - 0 KW - Fatty Acids, Nonesterified KW - Gentamicins KW - Hydroxymercuribenzoates KW - Insulin KW - Lysophospholipids KW - 4-hydroxymercuribenzoate KW - 138-85-2 KW - Ionomycin KW - 56092-81-0 KW - Lanthanum KW - 6I3K30563S KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Glucose KW - IY9XDZ35W2 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Ethers -- pharmacology KW - Insulin -- secretion KW - Biological Transport -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Phospholipases A -- pharmacology KW - Glucose -- pharmacology KW - Lanthanum -- pharmacology KW - Fatty Acids, Nonesterified -- biosynthesis KW - Male KW - Gentamicins -- pharmacology KW - Hydroxymercuribenzoates -- pharmacology KW - Calcium -- metabolism KW - Islets of Langerhans -- drug effects KW - Lysophospholipids -- pharmacology KW - Islets of Langerhans -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78107596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Mobilization+of+cellular+Ca2%2B+by+lysophospholipids+in+rat+islets+of+Langerhans.&rft.au=Metz%2C+S+A&rft.aulast=Metz&rft.aufirst=S&rft.date=1988-02-22&rft.volume=968&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-29 N1 - Date created - 1988-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Gastritis. Bringing this enigma into sharper focus. AN - 78118425; 3344261 AB - Type A and type B (probably Campylobacter pylori) gastritis are distinct clinical (but largely asymptomatic) and histologic entities that can be separated from other disease processes. While the association of C pylori gastritis with peptic ulcer disease is well documented, no causal relationship has been established. Acute inflammatory conditions of the stomach secondary to other disease processes, macroscopic abnormalities of the gastric mucosa, and sometimes poorly characterized epigastric pain all carry the name "gastritis." The fact that, as a disease, gastritis remains an enigma largely stems from the multiple implications of the term. An accurate classification system of the gastritides would be helpful but is not yet available. Until it is, the term "gastritis" will have more meaning if accompanied by a description of the type of gastritis or of the responsible etiologic factor, secondary disease, or toxic insult (eg, gastric mucosal injury associated with use of nonsteroidal antiinflammatory drugs). Deletion of the term "gastritis" from the clinical vocabulary and substitution of better terms (eg, "nonulcer dyspepsia," "irritable bowel syndrome") will also serve to clarify the issue. JF - Postgraduate medicine AU - Michaletz, P A AU - Graham, D Y AD - Veterans Administration Medical Center, Houston, TX 77030. Y1 - 1988/02/15/ PY - 1988 DA - 1988 Feb 15 SP - 98 EP - 100, 103-6 VL - 83 IS - 3 SN - 0032-5481, 0032-5481 KW - Abridged Index Medicus KW - Index Medicus KW - Dyspepsia -- complications KW - Humans KW - Duodenal Ulcer -- complications KW - Stomach Ulcer -- complications KW - Campylobacter Infections -- complications KW - Campylobacter Infections -- diagnosis KW - Gastritis -- etiology KW - Gastritis -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78118425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Gastritis.+Bringing+this+enigma+into+sharper+focus.&rft.au=Michaletz%2C+P+A%3BGraham%2C+D+Y&rft.aulast=Michaletz&rft.aufirst=P&rft.date=1988-02-15&rft.volume=83&rft.issue=3&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Superoxide mediates the toxicity of paraquat for cultured mammalian cells. AN - 78088143; 2828357 AB - To establish some of the necessary steps in the toxic action of paraquat for cultured mammalian cells, we isolated paraquat-resistant HeLa cells after lethal increments in concentration of paraquat in the medium. The paraquat-resistant cells had increased the cellular content of both the Mn-containing and the CuZn-containing superoxide dismutases. The effect of paraquat on the consumption of oxygen by the wild-type and the resistance cells was similar; in both cases exposure to paraquat for 24 or more hours produced similar proportions of cyanide-resistant consumption of oxygen, suggesting that paraquat entered both cells, underwent reduction, and donated electrons to molecular oxygen. When cultivated for 5 months in the absence of paraquat the paraquat-resistant cells maintained the increased cellular content of superoxide dismutases and remained resistant to paraquat. This observation suggested that resistance to paraquat might be caused by enrichment for the two superoxide dismutases and, further, that the increased cellular content of the two enzymes was not a response to growth under stressful conditions. NIH/3T3 cells whose content of superoxide dismutase was increased by transcription of the transfected cDNA for the human CuZn superoxide dismutase were also resistant to paraquat, suggesting strongly that paraquat promotes the formation of O2- as a necessary part of its cytotoxic effects in two types of cultured mammalian cells. JF - The Journal of biological chemistry AU - Krall, J AU - Bagley, A C AU - Mullenbach, G T AU - Hallewell, R A AU - Lynch, R E AD - Research Service, Salt Lake Veterans Administration Medical Center, Salt Lake City, Utah 84148. Y1 - 1988/02/05/ PY - 1988 DA - 1988 Feb 05 SP - 1910 EP - 1914 VL - 263 IS - 4 SN - 0021-9258, 0021-9258 KW - Superoxides KW - 11062-77-4 KW - Manganese KW - 42Z2K6ZL8P KW - DNA KW - 9007-49-2 KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Zinc KW - J41CSQ7QDS KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - Catalase -- metabolism KW - Manganese -- metabolism KW - Base Sequence KW - Tumor Cells, Cultured -- drug effects KW - Transfection KW - Humans KW - DNA -- metabolism KW - Zinc -- metabolism KW - Superoxide Dismutase -- metabolism KW - Transcription, Genetic KW - Superoxides -- metabolism KW - HeLa Cells -- drug effects KW - Paraquat -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78088143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Superoxide+mediates+the+toxicity+of+paraquat+for+cultured+mammalian+cells.&rft.au=Krall%2C+J%3BBagley%2C+A+C%3BMullenbach%2C+G+T%3BHallewell%2C+R+A%3BLynch%2C+R+E&rft.aulast=Krall&rft.aufirst=J&rft.date=1988-02-05&rft.volume=263&rft.issue=4&rft.spage=1910&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-07 N1 - Date created - 1988-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A new technique for interpreting the BAER in cochlear disease. AN - 85277022; pmid-3377442 AB - We found, by studying 20 normal ears and 34 ears with cochlear disease, that the brainstem auditory evoked response (BAER) wave I latency was a good predictor of the I-V interval (r = -0.67, p less than 0.001), whereas hearing loss had little predictive value. The normal and hearing-loss groups generated regression lines (wave I latency vs I-V latency) that did not differ significantly from each other. A normal range of I-V intervals can be established for any wave I latency, increasing the sensitivity of the BAER. JF - Annals of Neurology AU - Tomasulo, R A AU - Peele, P B AD - Salem, VA, Veterans Administration Medical Center. PY - 1988 SP - 204 EP - 206 VL - 23 IS - 2 SN - 0364-5134, 0364-5134 KW - Cochlea KW - Human KW - Brain Stem KW - Labyrinth Diseases KW - Male KW - Evoked Potentials, Auditory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85277022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Neurology&rft.atitle=A+new+technique+for+interpreting+the+BAER+in+cochlear+disease.&rft.au=Tomasulo%2C+R+A%3BPeele%2C+P+B&rft.aulast=Tomasulo&rft.aufirst=R&rft.date=1988-02-01&rft.volume=23&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Annals+of+Neurology&rft.issn=03645134&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cutaneous pseudo abscesses: an unusual presentation of severe pancreatitis. AN - 85218041; pmid-3341343 AB - In this report, we present a 53-yr-old man with extensive subcutaneous fat necrosis due to acute pancreatitis presenting as fluctuant collections resembling large multiple abscesses. The diagnosis was suggested by examination of the wound aspirate. Findings included absence of organisms on the gram stain, presence of fat globules on wet mount, and an elevated amylase in the wound aspirate. This dramatic presentation preceded any symptoms or signs of overt pancreatitis. JF - The American Journal of Gastroenterology AU - Manji, N AU - Hulyalkar, A R AU - Keroack, M A AU - Vekshtein, V I AU - Kirshenbaum, J M AU - Sugarman, D I AU - Chopra, S AD - Department of Medicine, Brockton-West Roxbury Veterans Administration Medical Center, Boston, Massachusetts. PY - 1988 SP - 177 EP - 179 VL - 83 IS - 2 SN - 0002-9270, 0002-9270 KW - Acute Disease KW - Necrosis KW - Diagnosis, Differential KW - Skin Diseases KW - Abscess KW - Human KW - Middle Age KW - Case Report KW - Fat Necrosis KW - Male KW - Pancreatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85218041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Cutaneous+pseudo+abscesses%3A+an+unusual+presentation+of+severe+pancreatitis.&rft.au=Manji%2C+N%3BHulyalkar%2C+A+R%3BKeroack%2C+M+A%3BVekshtein%2C+V+I%3BKirshenbaum%2C+J+M%3BSugarman%2C+D+I%3BChopra%2C+S&rft.aulast=Manji&rft.aufirst=N&rft.date=1988-02-01&rft.volume=83&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Listeria monocytogenes peritonitis. AN - 85213759; pmid-3341344 AB - Listeria monocytogenes peritonitis in a patient with cirrhosis and simultaneous soft tissue infection is reported. Six previously documented cases are reviewed. All seven patients were bacteremic, suggesting hematogenous seeding to the peritoneum as the pathogenic mechanism. Clinical and laboratory characteristics of L. monocytogenes peritonitis are compared with peritonitis of other bacterial etiologies. JF - The American Journal of Gastroenterology AU - Soto-Hernandez, J L AU - Nunley, D AU - Gutierrez, C C AU - Berk, S L AD - Department of Medicine, Veterans Administration Medical Center, Johnson City, Tennessee. PY - 1988 SP - 180 EP - 182 VL - 83 IS - 2 SN - 0002-9270, 0002-9270 KW - Human KW - Peritonitis KW - Middle Age KW - Case Report KW - Female KW - Male KW - Listeria Infections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Listeria+monocytogenes+peritonitis.&rft.au=Soto-Hernandez%2C+J+L%3BNunley%2C+D%3BGutierrez%2C+C+C%3BBerk%2C+S+L&rft.aulast=Soto-Hernandez&rft.aufirst=J&rft.date=1988-02-01&rft.volume=83&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Upper gastrointestinal bleeding in acute mesenteric thrombosis. AN - 85208574; pmid-3258607 AB - We report an unusual case of upper gastrointestinal bleeding secondary to superior mesenteric vein thrombosis and review the literature to assess the frequency of upper GI bleeding in patients with superior mesenteric vascular disease. Clinical features and laboratory and radiological findings are nonspecific; endoscopy and abdominal angiograms are helpful to rule out the common causes of GI bleeding and to suspect the diagnoses of superior mesenteric vein thrombosis. Without early surgical intervention, mortality is close to 100%. JF - Journal of Clinical Gastroenterology AU - Miyaki, C T AU - Park, Y S AU - Gopalswamy, N AD - Gastroenterology Division, Veterans Administration Medical Center, Dayton, OH 45428. PY - 1988 SP - 84 EP - 87 VL - 10 IS - 1 SN - 0192-0790, 0192-0790 KW - Human KW - Gastrointestinal Hemorrhage KW - Aged KW - Case Report KW - Mesenteric Veins KW - Male KW - Thrombosis KW - Mesenteric Vascular Occlusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Upper+gastrointestinal+bleeding+in+acute+mesenteric+thrombosis.&rft.au=Miyaki%2C+C+T%3BPark%2C+Y+S%3BGopalswamy%2C+N&rft.aulast=Miyaki&rft.aufirst=C&rft.date=1988-02-01&rft.volume=10&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Silent aspiration following stroke. AN - 85163994; pmid-3340301 AB - Neurogenic dysphagia following stroke is not limited to brainstem involvement. Among 21 patients with stroke, one-third demonstrated only unilateral signs. In eight patients with silent aspiration, less subjective complaints, weaker cough, and dysphonia occurred more often. Videofluoroscopy must be used liberally in unilateral and bilateral strokes. JF - Neurology AU - Horner, J AU - Massey, E W AD - Audiology/Speech Pathology Service, Veterans Administration Medical Center, Durham, NC 27705. PY - 1988 SP - 317 EP - 319 VL - 38 IS - 2 SN - 0028-3878, 0028-3878 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85163994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Silent+aspiration+following+stroke.&rft.au=Horner%2C+J%3BMassey%2C+E+W&rft.aulast=Horner&rft.aufirst=J&rft.date=1988-02-01&rft.volume=38&rft.issue=2&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis. AN - 78625750; 3145672 AB - The phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-didecanoate, which activate the enzyme protein kinase C, stimulated resorption in fetal rat long-bone cultures at concentrations of 1 and 10 microM. This effect appeared specific for active phorbol esters, since the inactive analogue 4-alpha-phorbol-12,13-didecanoate was without effect. The resorptive responses of fetal rat long-bone cultures to active phorbol esters differed from those previously described in newborn mouse calvaria cultures, since resorption stimulated by TPA in the rat long bones was not inhibited by either indomethacin (10 microM) or flufenamic acid (10 microM). However, calcitonin, an inhibitor of osteoclastic resorption, did decrease the response to TPA. There were some similarities between the response of fetal rat long-bone cultures to TPA and their response to epidermal growth factor (EGF). Like EGF, TPA stimulated DNA synthesis in the bones (measured as the incorporation of [3H]-thymidine) at concentrations below those necessary to stimulate resorption. TPA also did not stimulate resorption in the presence of aphidicolin (10 microM), an inhibitor of DNA synthesis that has been previously shown to block the resorptive response of these cultures to EGF. However, the responses of the cultures to TPA and EGF were not identical, since, unlike the effects of EGF, the stimulatory effects of TPA on DNA synthesis were biphasic. These results demonstrate that active phorbol esters stimulate bone resorption in fetal rat long-bone cultures through mechanisms that do not require prostaglandin synthesis but do appear to be mediated by osteoclasts.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Lorenzo, J A AU - Sousa, S AD - Department of Medicine, Veterans Administration Medical Center, Newington, CT. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 63 EP - 67 VL - 3 IS - 1 SN - 0884-0431, 0884-0431 KW - Diterpenes KW - 0 KW - Parathyroid Hormone KW - Phorbol Esters KW - Prostaglandins KW - phorbol-12,13-didecanoate KW - 24928-17-4 KW - Aphidicolin KW - 38966-21-1 KW - Flufenamic Acid KW - 60GCX7Y6BH KW - Epidermal Growth Factor KW - 62229-50-9 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Thymidine KW - VC2W18DGKR KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Diterpenes -- pharmacology KW - Animals KW - Prostaglandins -- biosynthesis KW - Epidermal Growth Factor -- pharmacology KW - DNA Replication -- drug effects KW - Indomethacin -- pharmacology KW - Thymidine -- metabolism KW - Rats KW - Calcium -- metabolism KW - Parathyroid Hormone -- pharmacology KW - Flufenamic Acid -- pharmacology KW - Organ Culture Techniques KW - Bone and Bones -- embryology KW - Phorbol Esters -- pharmacology KW - Bone Resorption -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78625750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Phorbol+esters+stimulate+bone+resorption+in+fetal+rat+long-bone+cultures+by+mechanisms+independent+of+prostaglandin+synthesis.&rft.au=Lorenzo%2C+J+A%3BSousa%2C+S&rft.aulast=Lorenzo&rft.aufirst=J&rft.date=1988-02-01&rft.volume=3&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-21 N1 - Date created - 1989-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Halogenated vapor anesthetics adversely influence edrophonium reversal. AN - 78376597; 3410589 AB - Reversal of the pancuronium induced neuromuscular block by edrophonium was studied in different groups of male surgical patients. All groups received similar premedication and identical induction of anesthesia. Neuromuscular function was monitored by the transduced response of the thumb adductor muscle to different [e.g. 0.2, 2 and 50 counts per second (cps)] supramaximal electrical stimuli applied to the ulnar nerve. When the regimen of anesthesia maintenance included halogenated vapor anesthetics the reversal of neuromuscular block was of lesser degree than in the case of N2O/O2 + fentanyl anesthesia. The reversal of the "fade-type" (e.g. tetanic and "train of four") responses was particularly incomplete with halothane and isoflurane. Compared with edrophonium, pyridostigmine was found to be more effective under halothane anesthesia. Based on these results, edrophonium may not be the first choice in the clinical reversal of deep levels of nondepolarizing neuromuscular block in the presence of vapor anesthetics. JF - International journal of clinical pharmacology, therapy, and toxicology AU - Gyermek, L AD - Department of Anesthesia, Veterans Administration Medical Center, Albuquerque, NM 87108. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 75 EP - 78 VL - 26 IS - 2 SN - 0174-4879, 0174-4879 KW - Anesthetics KW - 0 KW - Edrophonium KW - 70FP3JLY7N KW - Pancuronium KW - J76UF062FS KW - Pyridostigmine Bromide KW - KVI301NA53 KW - Index Medicus KW - Pancuronium -- antagonists & inhibitors KW - Drug Interactions KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Pyridostigmine Bromide -- therapeutic use KW - Male KW - Anesthetics -- adverse effects KW - Anesthesia, Inhalation KW - Resuscitation KW - Edrophonium -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78376597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+clinical+pharmacology%2C+therapy%2C+and+toxicology&rft.atitle=Halogenated+vapor+anesthetics+adversely+influence+edrophonium+reversal.&rft.au=Gyermek%2C+L&rft.aulast=Gyermek&rft.aufirst=L&rft.date=1988-02-01&rft.volume=26&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=International+journal+of+clinical+pharmacology%2C+therapy%2C+and+toxicology&rft.issn=01744879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-29 N1 - Date created - 1988-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pentazocine-naloxone experimenters among abusers of pentazocine and tripelennamine from a VA treatment population. AN - 78209851; 3366497 AB - Psychiatric diagnostic profiles, drug and personal histories, and social support measures were obtained for a clinic sample of abusers of pentazocine when the drug was withdrawn and re-released by the manufacturer compounded with the opiate antagonist naloxone. Nearly 50% of the sample (N = 99) reported using the new drug during the following 6 to 9 months, despite its reduced abuse potential. Reinterviews revealed that claimed use of pentazocine dropped to half. JF - The International journal of the addictions AU - True, W R AU - Poklis, A AU - Jamieson, R W AU - Seyfried, W AD - Veterans Administration Medical Center, St. Louis, Missouri 63125. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 217 EP - 226 VL - 23 IS - 2 SN - 0020-773X, 0020-773X KW - Naloxone KW - 36B82AMQ7N KW - Tripelennamine KW - 3C5ORO99TY KW - Pentazocine KW - RP4A60D26L KW - Index Medicus KW - Humans KW - Adult KW - Prognosis KW - Social Support KW - Male KW - Opioid-Related Disorders -- psychology KW - Naloxone -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78209851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Pentazocine-naloxone+experimenters+among+abusers+of+pentazocine+and+tripelennamine+from+a+VA+treatment+population.&rft.au=True%2C+W+R%3BPoklis%2C+A%3BJamieson%2C+R+W%3BSeyfried%2C+W&rft.aulast=True&rft.aufirst=W&rft.date=1988-02-01&rft.volume=23&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-13 N1 - Date created - 1988-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic effects of ethanol and its interaction with other drugs, hepatotoxic agents, vitamins, and carcinogens: a 1988 update. AN - 78196006; 3283942 JF - Seminars in liver disease AU - Lieber, C S AD - Section of Liver Disease and Nutrition and Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 47 EP - 68 VL - 8 IS - 1 SN - 0272-8087, 0272-8087 KW - Carcinogens KW - 0 KW - Pharmaceutical Preparations KW - Vitamins KW - Ethanol KW - 3K9958V90M KW - Alcohol Oxidoreductases KW - EC 1.1.- KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Oxidation-Reduction KW - Drug Interactions KW - Cell Membrane -- drug effects KW - Microsomes, Liver -- metabolism KW - Humans KW - Alcohol Oxidoreductases -- physiology KW - Microsomes, Liver -- physiology KW - Mitochondria, Liver -- drug effects KW - Lipid Metabolism KW - Biological Availability KW - Acetaldehyde -- adverse effects KW - Ethanol -- adverse effects KW - Pharmaceutical Preparations -- metabolism KW - Liver -- pathology KW - Ethanol -- pharmacokinetics KW - Carcinogens -- metabolism KW - Vitamins -- metabolism KW - Liver -- drug effects KW - Liver -- metabolism KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78196006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=Metabolic+effects+of+ethanol+and+its+interaction+with+other+drugs%2C+hepatotoxic+agents%2C+vitamins%2C+and+carcinogens%3A+a+1988+update.&rft.au=Lieber%2C+C+S&rft.aulast=Lieber&rft.aufirst=C&rft.date=1988-02-01&rft.volume=8&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=02728087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of ethanol on protein trafficking in the liver. AN - 78188119; 3283943 JF - Seminars in liver disease AU - Tuma, D J AU - Sorrell, M F AD - Liver Study Unit, Veterans Administration Medical Center, Omaha, NE 68105. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 69 EP - 80 VL - 8 IS - 1 SN - 0272-8087, 0272-8087 KW - Proteins KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Liver Diseases, Alcoholic -- metabolism KW - Cell Membrane -- drug effects KW - Humans KW - Endocytosis -- drug effects KW - Liver Diseases, Alcoholic -- physiopathology KW - Liver Diseases, Alcoholic -- etiology KW - Biological Transport -- drug effects KW - Proteins -- secretion KW - Ethanol -- adverse effects KW - Liver -- physiopathology KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Ethanol -- administration & dosage KW - Liver -- metabolism KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78188119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=Effects+of+ethanol+on+protein+trafficking+in+the+liver.&rft.au=Tuma%2C+D+J%3BSorrell%2C+M+F&rft.aulast=Tuma&rft.aufirst=D&rft.date=1988-02-01&rft.volume=8&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=02728087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Osteoporotic correlates of alcoholism in young males. AN - 78158807; 3357845 AB - A group of 22 white males (ages, 28 to 40 years) with histories of chronic alcohol abuse ranging from 1 to 21 years were evaluated for trabecular bone mineral density in the left femoral neck area. A group of age and weight-matched white males with no history of alcoholism served as controls. All participants completed medical history questionnaires regarding fracture history, dietary habits, medications, and physical activity. Singh femoral trabecular indices also were measured for the alcoholic participants. Analysis of bone mineral data as measured by dual photon absorptiometry revealed no statistically significant reduction in the bone mineral densities of the alcoholic group when compared to the controls. No differences were seen in the areas of the femoral neck, Ward's triangle, and greater trochanter. Duration of alcoholism also was not correlated with the degree of osteopenia. Singh index measurements of right and left femoral heads were compared and revealed no significant differences within individual patients. Left femoral Singh index values averaged 5.5 (range, 4 to 6) for the alcoholic group and were not indicative of decreased bone mineral density. It is concluded from this study that chronic alcoholism associated with heavy smoking most likely has a debilitating effect on the trabecular bone density of white males, yet clinical and radiographic evidence is not widely manifested in men under the age of 40 years. JF - Orthopedics AU - Harding, A AU - Dunlap, J AU - Cook, S AU - Mattalino, A AU - Azar, F AU - O'Brien, M AU - Kester, M AD - Rehabilitation Research and Development, Veterans Administration Medical Center, New Orleans, LA. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 279 EP - 282 VL - 11 IS - 2 SN - 0147-7447, 0147-7447 KW - Minerals KW - 0 KW - Index Medicus KW - Bone and Bones -- analysis KW - Humans KW - Adult KW - Male KW - Minerals -- analysis KW - Bone Diseases, Metabolic -- etiology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78158807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orthopedics&rft.atitle=Osteoporotic+correlates+of+alcoholism+in+young+males.&rft.au=Harding%2C+A%3BDunlap%2C+J%3BCook%2C+S%3BMattalino%2C+A%3BAzar%2C+F%3BO%27Brien%2C+M%3BKester%2C+M&rft.aulast=Harding&rft.aufirst=A&rft.date=1988-02-01&rft.volume=11&rft.issue=2&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Orthopedics&rft.issn=01477447&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-13 N1 - Date created - 1988-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Brain CT changes in alcoholics: effects of age and alcohol consumption. AN - 78145110; 3279864 AB - A computerized tomographic (CT) brain scan and assessments of lifetime alcohol consumption, body size, and cognitive performance were performed in 37 male alcoholics, aged 26-62 years. Hematocrit and mean corpuscular volume (MCV) were also measured. CT data were analyzed using a semiautomated scoring system yielding measures of percentage of fluid at the ventricles and cortical sulci. Normative brain CT data from 57 community controls spanning the adult age range allowed Z-score assessment of deviation from age norms for each alcoholic. Across the entire group, alcoholics had significantly enlarged ventricles and sulci for their age. Enlargement at both sites correlated significantly with lifetime alcohol consumption. Sulcal enlargement in alcoholics was found across all ages. In contrast, ventricular enlargement was apparent only in older alcoholics and became increasingly exaggerated with age. Measures of body size, hematocrit, and MCV correlated with ventricular but not sulcal enlargement, suggesting that nutritional factors play a role in ventricular enlargement. Associations between neuropsychological performance and CT changes or alcohol consumption were less pronounced and at times counterintuitive. The findings support a modest dose-effect relationship between ethanol exposure and changes in brain morphology, and suggest that ventricles and sulci show a different time course of response. The role of nutritional status needs to be more closely investigated. JF - Alcoholism, clinical and experimental research AU - Pfefferbaum, A AU - Rosenbloom, M AU - Crusan, K AU - Jernigan, T L AD - Veterans Administration Medical Center, Palo Alto, California 94304. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 81 EP - 87 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Serum Albumin KW - 0 KW - Index Medicus KW - Serum Albumin -- metabolism KW - Age Factors KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Cerebral Ventricles -- pathology KW - Hematocrit KW - Aged KW - Middle Aged KW - Neuropsychological Tests KW - Liver Function Tests KW - Erythrocyte Indices KW - Alcoholism -- pathology KW - Substance-Related Disorders -- pathology KW - Tomography, X-Ray Computed KW - Alcohol Drinking -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78145110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Brain+CT+changes+in+alcoholics%3A+effects+of+age+and+alcohol+consumption.&rft.au=Pfefferbaum%2C+A%3BRosenbloom%2C+M%3BCrusan%2C+K%3BJernigan%2C+T+L&rft.aulast=Pfefferbaum&rft.aufirst=A&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increase in tryptophan oxygenase activity in alcoholic patients. AN - 78135671; 3279850 AB - This study was conducted in order to assess whether chronic excessive alcohol consumption affects the activity of the liver enzyme tryptophan oxygenase which is rate limiting along the most important pathway of tryptophan catabolism. Five alcoholics were studied twice, once shortly after admission to an inpatient unit and the second time 1 month later. On each study day patients were given a tryptophan load of 50 mg/kg. Kynurenine in the urines (which reflects tryptophan oxygenase activity) was measured for a period of 6 hr following the load and showed a significantly enhanced activity of the enzyme shortly after cessation of drinking. This increased activity could explain the lowered tryptophan levels we have previously reported in alcoholics. The increase in enzyme activity may have been mediated by a rise in glucocorticoid hormones. In all instances, plasma cortisol measured hourly for 6 hr after the start of the experiment, was higher shortly after cessation of drinking than 1 month later. JF - Alcoholism, clinical and experimental research AU - Buydens-Branchey, L AU - Branchey, M AU - Worner, T M AU - Zucker, D AU - Aramsombatdee, E AU - Lieber, C S AD - Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 163 EP - 167 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Kynurenine KW - 343-65-7 KW - Tryptophan KW - 8DUH1N11BX KW - Tryptophan Oxygenase KW - EC 1.13.11.11 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Kynurenine -- urine KW - Kinetics KW - Humans KW - Adult KW - Middle Aged KW - Tryptophan -- blood KW - Liver Function Tests KW - Protein Binding KW - Male KW - Hydrocortisone -- blood KW - Alcoholism -- enzymology KW - Tryptophan Oxygenase -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78135671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Increase+in+tryptophan+oxygenase+activity+in+alcoholic+patients.&rft.au=Buydens-Branchey%2C+L%3BBranchey%2C+M%3BWorner%2C+T+M%3BZucker%2C+D%3BAramsombatdee%2C+E%3BLieber%2C+C+S&rft.aulast=Buydens-Branchey&rft.aufirst=L&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin. AN - 78134415; 2894456 AB - Aluminum is a neurotoxin capable of altering membrane structure and function. We investigated whether aluminum also can affect saturable transport across membranes using the blood-brain barrier as our model. Mice were given i.p. or i.v. aluminum (up to 100 mg/kg) as the chloride salt and the disappearance from the brain of several centrally administered substances was measured. We found that aluminum rapidly and profoundly inhibited the saturable system that transports the small, N-tyrosinated peptides Tyr-MIF-1 and the enkephalins from the brain to the blood by acting as a noncompetitive inhibitor. In contrast, the disappearance from the brain of technetium pertechnetate (a substance also transported out of the brain by a different saturable system), albumin or D-Tyr-MIF-1 (a stereoisomer of Tyr-MIF-1 that was confirmed not to be transported by the carrier system) was not affected by aluminum. Aluminum also did not alter either the saturable or nonsaturable component of the uptake of Tyr-MIF-1 by erythrocytes. These findings suggest that one mechanism by which aluminum may induce neurotoxicity is by selective alteration of the transport systems of the blood-brain barrier. JF - The Journal of pharmacology and experimental therapeutics AU - Banks, W A AU - Kastin, A J AU - Fasold, M B AD - Veterans Administration Medical Center, New Orleans, Louisiana. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 579 EP - 585 VL - 244 IS - 2 SN - 0022-3565, 0022-3565 KW - Albumins KW - 0 KW - Enkephalins KW - Technetium KW - 7440-26-8 KW - tyrosyl-prolyl-leucyl-glycinamide KW - 77133-61-0 KW - MSH Release-Inhibiting Hormone KW - 9083-38-9 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Kinetics KW - Mice KW - Enkephalins -- pharmacokinetics KW - Erythrocytes -- metabolism KW - Male KW - Biological Transport -- drug effects KW - MSH Release-Inhibiting Hormone -- pharmacokinetics KW - Blood-Brain Barrier -- drug effects KW - Technetium -- pharmacokinetics KW - MSH Release-Inhibiting Hormone -- analogs & derivatives KW - Aluminum -- pharmacology KW - Albumins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78134415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Differential+effect+of+aluminum+on+the+blood-brain+barrier+transport+of+peptides%2C+technetium+and+albumin.&rft.au=Banks%2C+W+A%3BKastin%2C+A+J%3BFasold%2C+M+B&rft.aulast=Banks&rft.aufirst=W&rft.date=1988-02-01&rft.volume=244&rft.issue=2&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-12 N1 - Date created - 1988-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity of ethanol and other components of alcoholic beverages. AN - 78133777; 3279855 JF - Alcoholism, clinical and experimental research AU - Feinman, L AU - Lieber, C S AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York 10468. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 2 EP - 6 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Alcoholic Beverages -- adverse effects KW - Alcohol Drinking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78133777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Toxicity+of+ethanol+and+other+components+of+alcoholic+beverages.&rft.au=Feinman%2C+L%3BLieber%2C+C+S&rft.aulast=Feinman&rft.aufirst=L&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prostaglandin E2 is an inhibitor of adenylate cyclase in rabbit proximal tubule. AN - 78131659; 3162352 AB - Prostaglandin E1 and E2 (PGE) antagonize the phosphaturic effect of parathyroid hormone (PTH), but do not alter the phosphaturia evoked by adenosine 3',5'-cyclic monophosphate (cAMP) analogues. These findings support the idea that PGE interfere with activation of adenylate cyclase in the renal proximal tubule. We tested this hypothesis in the rabbit renal proximal straight tubule (PST). In the PST, adenylate cyclase was activated by PTH (Km = 10(-9) M PTH), but not by PGE2, which attenuated the activation of adenylate cyclase by PTH. The inhibition by PGE2 of PTH action was prevented by pertussis toxin, which deactivates the regulatory aggregate, Ni. In the PST, PGE2 also attenuated the activation of adenylate cyclase by cholera toxin. The inhibitory effect of PGE2 was selective; PGE2 did not inhibit activation of adenylate cyclase in glomeruli, but it inhibited the enzyme in proximal convoluted tubules (PCT) and PST. We conclude that PGE2 inhibits adenylate cyclase in rabbit proximal tubule. We propose that this action may, in part, regulate transport function in vivo. JF - The American journal of physiology AU - Dominguez, J H AU - Shuler, F AU - Olszowy, M W AU - Brown, T AU - Puschett, J B AD - Nephrology Division, Veterans Administration Medical Center, Indianapolis, Indiana. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - C304 EP - C309 VL - 254 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Adenylate Cyclase Toxin KW - 0 KW - Enzyme Inhibitors KW - Parathyroid Hormone KW - Prostaglandins E KW - Virulence Factors, Bordetella KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cholera Toxin -- pharmacology KW - Kidney Glomerulus -- enzymology KW - Rabbits KW - Virulence Factors, Bordetella -- pharmacology KW - Parathyroid Hormone -- pharmacology KW - In Vitro Techniques KW - Enzyme Inhibitors -- pharmacology KW - Female KW - Prostaglandins E -- pharmacology KW - Adenylyl Cyclases -- metabolism KW - Kidney Tubules, Proximal -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78131659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Prostaglandin+E2+is+an+inhibitor+of+adenylate+cyclase+in+rabbit+proximal+tubule.&rft.au=Dominguez%2C+J+H%3BShuler%2C+F%3BOlszowy%2C+M+W%3BBrown%2C+T%3BPuschett%2C+J+B&rft.aulast=Dominguez&rft.aufirst=J&rft.date=1988-02-01&rft.volume=254&rft.issue=2+Pt+1&rft.spage=C304&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-11 N1 - Date created - 1988-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Initial sensitivity and tolerance to ethanol in mice genetically selected for diazepam sensitivity. AN - 78128666; 2831751 AB - The benzodiazepine (BZ) receptor is coupled with a GABA-receptor chloride-ionophore complex. The BZs augment the GABA-induced increase in chloride conductance, which leads to postsynaptic inhibition. This effect is believed to be responsible for antianxiety, sedative, muscle relaxant, and anticonvulsant effects, but the mechanisms underlying these behavioral effects are poorly understood. Various other sedative-hypnotics, including ethanol and barbiturates, interact with this system, probably contributing to their behavioral effects. We have recently conducted a selective breeding program to develop lines of mice which are diazepam-resistant (DR) and sensitive (DS) (Gallaher EJ, Hollister LE, Gionet SE, Crabbe JC. Psychopharmacology, 93:25-30, 1987); when tested for the duration of rotarod impairment after 20 mg/kg diazepam the DR line was impaired for 71 +/- 13 min compared with 200 +/- 18 min in the DS line. In the current study we tested mice from the DR and DS lines to determine if BZ sensitivity generalized to ethanol. DS mice became ataxic with lower brain ethanol concentrations, and recovered at later times and with lower blood ethanol concentrations, than did DR mice, indicating that sensitivity differences did extend to ethanol. Following a series of sequential doses over 5 to 6 hr DS mice developed minimal rapid tolerance, whereas DR mice developed considerable tolerance. By the end of the day DS mice were therefore much more sensitive to ethanol than were DR mice; this difference was greater in males than in females. High dose ethanol toxicity was studied by assaying brain ethanol concentrations at the cessation of respiration; no differences were found between lines or sexes. JF - Alcoholism, clinical and experimental research AU - Gallaher, E J AU - Gionet, S E AD - Veterans Administration Medical Center, Palo Alto, California. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 77 EP - 80 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Receptors, GABA-A KW - 0 KW - Ethanol KW - 3K9958V90M KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Mice, Inbred Strains KW - Drug Tolerance KW - Animals KW - Brain -- drug effects KW - Receptors, GABA-A -- drug effects KW - Mice KW - Brain -- metabolism KW - Genotype KW - Ethanol -- pharmacokinetics KW - Ethanol -- pharmacology KW - Arousal -- drug effects KW - Motor Skills -- drug effects KW - Diazepam -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78128666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Initial+sensitivity+and+tolerance+to+ethanol+in+mice+genetically+selected+for+diazepam+sensitivity.&rft.au=Gallaher%2C+E+J%3BGionet%2C+S+E&rft.aulast=Gallaher&rft.aufirst=E&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Red blood cell deformability in human and experimental sepsis. AN - 78111434; 3277585 AB - Red blood cell (RBC) "deformability" is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 +/- 0.12) compared with patients without sepsis (1.62 +/- 0.13) and normal control volunteers (1.51 +/- 0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37 +/- 0.06) compared with that of sham-operated rats (0.76 +/- 0.12), as well as in endotoxemic rats (0.38 +/- 0.4) compared with control rats (0.82 +/- 0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function. JF - Archives of surgery (Chicago, Ill. : 1960) AU - Hurd, T C AU - Dasmahapatra, K S AU - Rush, B F AU - Machiedo, G W AD - Surgical Service, Veterans Administration Medical Center, East Orange, NJ. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 217 EP - 220 VL - 123 IS - 2 SN - 0004-0010, 0004-0010 KW - Endotoxins KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Oxygen Consumption KW - Humans KW - Escherichia coli KW - Endotoxins -- toxicity KW - Male KW - Bacterial Infections -- blood KW - Surgical Wound Infection -- blood KW - Erythrocyte Deformability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78111434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Red+blood+cell+deformability+in+human+and+experimental+sepsis.&rft.au=Hurd%2C+T+C%3BDasmahapatra%2C+K+S%3BRush%2C+B+F%3BMachiedo%2C+G+W&rft.aulast=Hurd&rft.aufirst=T&rft.date=1988-02-01&rft.volume=123&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00040010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-08 N1 - Date created - 1988-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of the anion gap in clinical medicine. AN - 78098265; 3277288 AB - The anion gap (AG) in the serum equals the concentrations of Na-(Cl + HCO3). It is becoming increasingly useful in the interpretation of acid-base disorders and in the diagnosis of other conditions. In an acidemic patient, an elevated AG usually indicates the presence of an organic acidosis, rhabdomyolysis, nonketotic hyperglycemic coma, uremia, or certain intoxications. An increased AG with alkalemia suggests severe alkalosis with hemoconcentration or use of anionic antibiotics (eg, carbenicillin) or salts of organic acids (eg, citrate). An elevated AG with a normal serum pH could be an artifact caused by prolonged exposure of the serum sample to air before processing. A decreased AG with a normal serum pH may indicate hypoalbuminemia, cationic paraproteinemia, halide poisoning, or lithium intoxication. The delta AG/delta HCO3 ratio and the urinary AG may also be quite useful in analyzing complex acid-base disorders. JF - Southern medical journal AU - Oster, J R AU - Perez, G O AU - Materson, B J AD - Medical Service, Veterans Administration Medical Center, Miami, FL 33125. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 229 EP - 237 VL - 81 IS - 2 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Diagnosis, Differential KW - Acid-Base Imbalance -- metabolism KW - Humans KW - Acidosis -- etiology KW - Multiple Myeloma -- metabolism KW - Gastric Juice -- analysis KW - Diarrhea -- metabolism KW - Diarrhea -- complications KW - Acid-Base Imbalance -- diagnosis KW - Acidosis -- diagnosis KW - Acid-Base Equilibrium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78098265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Use+of+the+anion+gap+in+clinical+medicine.&rft.au=Oster%2C+J+R%3BPerez%2C+G+O%3BMaterson%2C+B+J&rft.aulast=Oster&rft.aufirst=J&rft.date=1988-02-01&rft.volume=81&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. AN - 78090686; 3339131 AB - Parathyroid hormone-like adenylate cyclase-stimulating proteins (hACSPs) have been implicated as one of the calcemic, bone-resorbing agents in patients with humoral hypercalcemia of malignancy. We report the synthesis of an amino-terminal hACSP fragment, Tyr36 hACSP (1-36) amide. The synthetic hACSP is a potent agonist of renal membrane adenylate cyclase (Km, 1.7 X 10(-10)) and of bone cell adenylate cyclase (Km 1 X 10(-9)M). It is a potent bone-resorbing agent in vitro, stimulating 45Ca release from fetal rat long bones at a concentration of 10(-9) M. When infused via osmotic minipumps into rats, it is also a potent calcemic factor in vivo, inducing a rise in serum calcium from (mean +/- SD) 10.6 +/- 0.6 to 19.7 +/- 3.2 mg/dl when infused at 1.4 micrograms/h and from 9.9 +/- 0.7 to 11.4 +/- 1.2 mg/dl when infused at 0.14 micrograms/h. These findings indicate that biologically active hACSP fragments can be synthesized. One such synthetic peptide possesses the in vitro and in vivo bioactivities demonstrated in native, tumor-derived hACSPs. It is also a potent calcemic, bone-resorbing agent. JF - The Journal of clinical investigation AU - Stewart, A F AU - Mangin, M AU - Wu, T AU - Goumas, D AU - Insogna, K L AU - Burtis, W J AU - Broadus, A E AD - Department of Endocrinology, West Haven Veterans Administration Medical Center, Connecticut 06516. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 596 EP - 600 VL - 81 IS - 2 SN - 0021-9738, 0021-9738 KW - Neoplasm Proteins KW - 0 KW - Parathyroid Hormone KW - Recombinant Proteins KW - parathyroid hormone-like adenylate cyclase-stimulating protein, human KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Abridged Index Medicus KW - Index Medicus KW - Parathyroid Hormone -- pharmacology KW - Base Sequence KW - Recombinant Proteins -- pharmacology KW - Humans KW - Molecular Sequence Data KW - Enzyme Activation -- drug effects KW - Adenylyl Cyclases -- metabolism KW - Amino Acid Sequence KW - Cloning, Molecular KW - Bone Resorption -- drug effects KW - Neoplasm Proteins -- genetics KW - Hypercalcemia -- chemically induced KW - Neoplasm Proteins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78090686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Synthetic+human+parathyroid+hormone-like+protein+stimulates+bone+resorption+and+causes+hypercalcemia+in+rats.&rft.au=Stewart%2C+A+F%3BMangin%2C+M%3BWu%2C+T%3BGoumas%2C+D%3BInsogna%2C+K+L%3BBurtis%2C+W+J%3BBroadus%2C+A+E&rft.aulast=Stewart&rft.aufirst=A&rft.date=1988-02-01&rft.volume=81&rft.issue=2&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1977 Aug 25;252(16):5847-51 [885886] J Clin Invest. 1965 Jan;44:103-16 [14254246] Cancer. 1982 Apr 1;49(7):1449-55 [6277464] J Clin Endocrinol Metab. 1982 Aug;55(2):219-27 [7085851] Calcif Tissue Int. 1982;34(6):553-7 [6819076] J Clin Invest. 1983 Mar;71(3):769-74 [6298282] Proc Natl Acad Sci U S A. 1983 Mar;80(5):1454-8 [6298791] J Clin Invest. 1983 Oct;72(4):1511-5 [6685137] Clin Sci (Lond). 1984 Feb;66(2):187-91 [6692653] Physiol Rev. 1984 Jul;64(3):985-1053 [6330779] Endocrinology. 1985 Jan;116(1):469-71 [2981075] J Clin Endocrinol Metab. 1985 Jun;60(6):1144-7 [2987287] J Immunol. 1985 Oct;135(4):2562-8 [3875658] Cancer Res. 1985 Nov;45(11 Pt 1):5358-63 [2996759] J Clin Invest. 1985 Nov;76(5):2016-9 [3877079] Science. 1986 Jan 24;231(4736):388-90 [2417317] Nature. 1986 Feb 6-12;319(6053):516-8 [3511389] Endocrinology. 1986 Mar;118(3):1200-10 [3948772] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7557-60 [3463984] Endocrinology. 1987 Feb;120(2):504-11 [3026777] Endocrinology. 1987 May;120(5):2029-36 [3106013] Endocrinology. 1987 May;120(5):2183-5 [3494596] J Biol Chem. 1987 May 25;262(15):7151-6 [3584110] J Clin Endocrinol Metab. 1987 Jul;65(1):105-9 [3034948] Proc Natl Acad Sci U S A. 1987 Jul;84(14):5048-52 [2885845] Biochem Biophys Res Commun. 1987 Jul 31;146(2):672-8 [3619898] J Bone Miner Res. 1987 Feb;2(1):37-43 [3455155] J Bone Miner Res. 1987 Dec;2(6):587-93 [3455636] N Engl J Med. 1980 Dec 11;303(24):1377-83 [6253785] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Brown recluse spider bites of the upper extremity. AN - 78090295; 3340871 AB - Brown recluse spider bites may cause painful, necrotic, slow-healing wounds. When these bites involve the hand and upper extremity, they can also create severe functional deficits and long-term disability. We reviewed an 11-year experience with brown recluse bites to the hand and upper extremity. Data from patients (n = 31) indicated a 20% incidence of functional complications (n = 6) unless conservative wound management, dapsone, and antibiotics were used. Delayed surgical excision was preferable until wounds were free from active inflammation. Painful, recurrent wound breakdown and hand dysfunction were more common with early surgical excision. These complications were successfully treated with steroids, sympathetic blockade, and early aggressive physical therapy. JF - Southern medical journal AU - DeLozier, J B AU - Reaves, L AU - King, L E AU - Rees, R S AD - Department of Plastic Surgery, Veterans Administration Medical Center, Nashville, Tenn. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 181 EP - 184 VL - 81 IS - 2 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Wound Healing KW - Humans KW - Hand -- pathology KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Spider Bites -- pathology KW - Spider Bites -- complications KW - Arm -- pathology KW - Spider Bites -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78090295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Brown+recluse+spider+bites+of+the+upper+extremity.&rft.au=DeLozier%2C+J+B%3BReaves%2C+L%3BKing%2C+L+E%3BRees%2C+R+S&rft.aulast=DeLozier&rft.aufirst=J&rft.date=1988-02-01&rft.volume=81&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Expression of cell-surface antigens on rat colonic cancer cells. AN - 78026703; 3335310 AB - Previously, we reported that two glycoproteins, carcinoembryonic antigen and secretory component, are preferentially expressed on the apical or laterobasal surfaces, respectively, of normal human colonic epithelial cells, whereas these antigens may be expressed over the entire cell surface of colonic cancer cells. These observations have prompted us to develop an animal model of aberrantly distributed normal surface antigens in colonic carcinoma. We prepared four monoclonal antibodies, three of which react specifically with antigens located on the microvillus surface and one that reacts specifically with the laterobasal surface of normal rat colonocytes. Three of the four cell-surface antigens were expressed by cells at all levels of the colonic crypt, but one of the microvillar antigens (p66) was expressed only on the mature colonocytes at the luminal surface. We then documented that a microvillus antigen (p66) detected by one of the antibodies and a laterobasal membrane antigen detected by another antibody were expressed over the entire surface of poorly differentiated colonic carcinoma cells induced by dimethylhydrazine. p66 was more often expressed on poorly differentiated colonic cancers than were the other three antigens. These observations indicate that (a) polarity of surface membrane antigens is a characteristic of normal rat colonic epithelial cells, (b) this polarity is not present in some experimental colonic carcinomas, and (c) the malignant phenotype of colonic carcinoma cells does not result merely from a block in normal differentiation of colonocytes. JF - Gastroenterology AU - Sugiyama, T AU - Brown, W R AU - Ahnen, D J AD - Department of Medicine, Denver Veterans Administration Medical Center, Colorado. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 331 EP - 342 VL - 94 IS - 2 SN - 0016-5085, 0016-5085 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, Neoplasm KW - Antigens, Surface KW - Dimethylhydrazines KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Microvilli -- immunology KW - Adenocarcinoma -- chemically induced KW - Adenocarcinoma -- immunology KW - Molecular Weight KW - Rats KW - Rats, Inbred F344 KW - Adenoma -- chemically induced KW - Adenoma -- immunology KW - Enzyme-Linked Immunosorbent Assay KW - Immunohistochemistry KW - Male KW - Immunoassay KW - Antigens, Neoplasm -- analysis KW - Colonic Neoplasms -- immunology KW - Colonic Neoplasms -- chemically induced KW - Antigens, Surface -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78026703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Expression+of+cell-surface+antigens+on+rat+colonic+cancer+cells.&rft.au=Sugiyama%2C+T%3BBrown%2C+W+R%3BAhnen%2C+D+J&rft.aulast=Sugiyama&rft.aufirst=T&rft.date=1988-02-01&rft.volume=94&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Life events stress and psychosocial factors in men with peptic ulcer disease. II. Relationships with serum pepsinogen concentrations and behavioral risk factors. AN - 78026637; 3335309 AB - We examined in a controlled study whether psychologic disturbances in men with peptic ulcer disease were related to other potential ulcer "risk factors" (serum pepsinogen concentrations, cigarette smoking, and intake of alcohol, aspirin, or coffee). Psychopathology in general, personality features of hostility, irritability, and hypersensitivity, and impaired coping ability (low ego strength) each correlated significantly with serum pepsinogen concentration in ulcer patients (p less than or equal to 0.005). Cigarette smoking and intake of alcohol and aspirin were increased in ulcer patients but unrelated to psychopathology. Depression was the variable that best discriminated ulcer patients from nonulcer controls; a negative perception of life events, number of relatives with ulcer, and serum pepsinogen I concentration also had a major, unique discriminating value, whereas smoking played a relatively minor role independent of the other variables examined. Our study supports the concept that several interacting factors (psychologic, behavioral, and genetic/physiologic) are likely involved in peptic ulcer disease. Emotional stress may predispose to ulcers by producing gastric hypersecretion, as manifested by hyperpepsinogenemia. JF - Gastroenterology AU - Walker, P AU - Luther, J AU - Samloff, I M AU - Feldman, M AD - Veterans Administration Medical Center, Dallas, Texas. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 323 EP - 330 VL - 94 IS - 2 SN - 0016-5085, 0016-5085 KW - Coffee KW - 0 KW - Pepsinogens KW - Acetaminophen KW - 362O9ITL9D KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Smoking KW - Life Change Events KW - Aspirin -- adverse effects KW - Risk Factors KW - Humans KW - Acetaminophen -- adverse effects KW - Personality KW - Coffee -- adverse effects KW - Alcohol Drinking KW - Male KW - Pepsinogens -- blood KW - Behavior KW - Peptic Ulcer -- blood KW - Peptic Ulcer -- psychology KW - Peptic Ulcer -- etiology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78026637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Life+events+stress+and+psychosocial+factors+in+men+with+peptic+ulcer+disease.+II.+Relationships+with+serum+pepsinogen+concentrations+and+behavioral+risk+factors.&rft.au=Walker%2C+P%3BLuther%2C+J%3BSamloff%2C+I+M%3BFeldman%2C+M&rft.aulast=Walker&rft.aufirst=P&rft.date=1988-02-01&rft.volume=94&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preliminary observations on the effect of mantle field radiotherapy on salivary flow rates in patients with Hodgkin's disease. AN - 78025602; 11039070 AB - Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reductions of 54% for non-stimulated saliva and 55.7% for paraffin-stimulated saliva were observed post-radiotherapy. Flow rates had not returned to pre-irradiation levels in any of the patients who were observed for two to three months after completion of therapy. Results obtained from this preliminary study indicate that most patients who receive therapeutic doses of radiation to a mantle field experience a significant reduction in salivary output which is manifest during the period of treatment and persists for a period of at least two to three months post-radiotherapy. JF - Journal of dental research AU - Bucher, J A AU - Fleming, T J AU - Fuller, L M AU - Keene, H J AD - Veterans Administration Medical Center, Dental Service, Dayton, Ohio 45428, USA. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 518 EP - 521 VL - 67 IS - 2 SN - 0022-0345, 0022-0345 KW - Dentistry KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Saliva -- secretion KW - Physical Stimulation KW - Secretory Rate -- radiation effects KW - Male KW - Female KW - Salivary Glands -- radiation effects KW - Lymphatic Irradiation -- methods KW - Lymphatic Irradiation -- adverse effects KW - Hodgkin Disease -- radiotherapy KW - Salivation -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78025602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dental+research&rft.atitle=Preliminary+observations+on+the+effect+of+mantle+field+radiotherapy+on+salivary+flow+rates+in+patients+with+Hodgkin%27s+disease.&rft.au=Bucher%2C+J+A%3BFleming%2C+T+J%3BFuller%2C+L+M%3BKeene%2C+H+J&rft.aulast=Bucher&rft.aufirst=J&rft.date=1988-02-01&rft.volume=67&rft.issue=2&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Journal+of+dental+research&rft.issn=00220345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uptake and intracellular distribution of doxorubicin metabolites in B-lymphocytes of chronic lymphocytic leukemia. AN - 78024857; 3257165 AB - The toxicity of doxorubicin metabolites was evaluated on lymphocytes of B-cell chronic lymphocytic leukemia. Only doxorubicinol was found to be cytotoxic for these lymphocytes, whereas exposure to aglycones at concentrations as high as 5 microM for 1 h had no effect on the proliferative capacity of these cells. After exposure of cells to isomolar concentrations of doxorubicin or its metabolites, uptake/retention of doxorubicinol was 23% of doxorubicin, and uptake/retention of aglycones was 5 to 13% of doxorubicin. Seventy to 90% of doxorubicin and 60 to 90% of doxorubicinol taken up/retained by the cells were detected in the cell nuclear fraction, whereas only 20 to 40% of the aglycones were localized in the cell nucleus. Cytotoxicity of metabolites was generally related to the proportion of drug taken up/retained by the cells and localized to the nuclei. The low uptake and nuclear localization may be at least partially responsible for the lack of cytotoxicity of aglycones on B-lymphocytes from chronic lymphocytic leukemia. JF - Cancer research AU - Dessypris, E N AU - Brenner, D E AU - Baer, M R AU - Hande, K R AD - Division of Hematology, Veterans Administration Medical Center, Nashville, Tennessee 37203. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 503 EP - 506 VL - 48 IS - 3 SN - 0008-5472, 0008-5472 KW - Doxorubicin KW - 80168379AG KW - adriamycinol KW - HUH05KI4CF KW - Index Medicus KW - Tumor Cells, Cultured KW - Cell Nucleus -- metabolism KW - Cell Compartmentation KW - In Vitro Techniques KW - Biological Transport KW - Doxorubicin -- pharmacokinetics KW - Doxorubicin -- analogs & derivatives KW - Leukemia, Lymphoid -- metabolism KW - B-Lymphocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78024857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Uptake+and+intracellular+distribution+of+doxorubicin+metabolites+in+B-lymphocytes+of+chronic+lymphocytic+leukemia.&rft.au=Dessypris%2C+E+N%3BBrenner%2C+D+E%3BBaer%2C+M+R%3BHande%2C+K+R&rft.aulast=Dessypris&rft.aufirst=E&rft.date=1988-02-01&rft.volume=48&rft.issue=3&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lethal effects and cardiovascular effects of purified alpha- and theta-toxins from Clostridium perfringens. AN - 78023316; 2891775 AB - Shock, a common and frequently fatal manifestation of gas gangrene caused by Clostridium perfringens, is probably mediated by extracellular toxins. Previous studies implicating alpha-toxin as the major lethal factor were frequently done with preparations contaminated with a second lethal factor, theta-toxin. We purified alpha- and theta-toxins from C. perfringens and demonstrated that both were lethal to mice. We investigated the effects of these purified toxins on cardiovascular function in intact rabbits; both toxins caused profound hypotension and bradycardia within 40 min. Reduced cardiac output preceded the development of hypotension and bradycardia. Purified alpha-toxin produced a dose-dependent reduction in myocardial function in isolated rabbit atrial preparations. Purified theta-toxin did not directly inhibit myocardial function. Shock induced by alpha-toxin may be partly mediated by direct depression of myocardial function. theta-Toxin reduced cardiac output in intact animals but had no direct effects on isolated heart preparations at concentrations that induced shock in intact animals. These data suggest that theta-toxin-induced shock could be mediated by an endogenous myocardial depressant factor. JF - The Journal of infectious diseases AU - Stevens, D L AU - Troyer, B E AU - Merrick, D T AU - Mitten, J E AU - Olson, R D AD - Infectious Disease Service, Veterans Administration Medical Center, Boise, Idaho 83702. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 272 EP - 279 VL - 157 IS - 2 SN - 0022-1899, 0022-1899 KW - Bacterial Toxins KW - 0 KW - Calcium-Binding Proteins KW - Hemolysin Proteins KW - Clostridium perfringens theta-toxin KW - 71329-60-7 KW - Type C Phospholipases KW - EC 3.1.4.- KW - alpha toxin, Clostridium perfringens KW - EC 3.1.4.3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Heart Rate -- drug effects KW - Heart -- drug effects KW - Rabbits KW - Mice KW - Hemolysin Proteins -- toxicity KW - Blood Pressure -- drug effects KW - Cardiac Output -- drug effects KW - Male KW - Female KW - Hemodynamics -- drug effects KW - Clostridium perfringens KW - Shock, Septic -- etiology KW - Gas Gangrene -- complications KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78023316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Lethal+effects+and+cardiovascular+effects+of+purified+alpha-+and+theta-toxins+from+Clostridium+perfringens.&rft.au=Stevens%2C+D+L%3BTroyer%2C+B+E%3BMerrick%2C+D+T%3BMitten%2C+J+E%3BOlson%2C+R+D&rft.aulast=Stevens&rft.aufirst=D&rft.date=1988-02-01&rft.volume=157&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Patients' Suicides: Frequency and Impact on Psychiatrists AN - 61031901; 89U2135 AB - Results of a national questionnaire survey of randomly selected US psychiatrists (N = 259) reveal that 51% had had a patient who committed suicide, impacting both their personal & professional lives. Sixty-five Rs reported stress levels in the weeks following the suicide that were comparable to levels reported in studies of people seeking treatment after the death of a parent. Younger, less experienced clinicians were affected more. Implications of these results for the training & practice of psychiatrists are discussed. 1 Table, 15 References. HA JF - The American Journal of Psychiatry AU - Chemtob, Claude M AU - Hamada, Roger S AU - Bauer, Gordon AU - Kinney, Barry AU - Torigoe, Rodney Y AD - Veterans Administration Regional Office, PO Box 50188 Honolulu HI 96850 Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 224 EP - 228 VL - 145 IS - 2 SN - 0002-953X, 0002-953X KW - US psychiatrists, patient suicide effects KW - questionnaire survey KW - Occupational Stress KW - United States of America KW - Psychiatrists KW - Practitioner Patient Relationship KW - article KW - 1020: social differentiation; sociology of occupations & professions KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61031901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Patients%27+Suicides%3A+Frequency+and+Impact+on+Psychiatrists&rft.au=Chemtob%2C+Claude+M%3BHamada%2C+Roger+S%3BBauer%2C+Gordon%3BKinney%2C+Barry%3BTorigoe%2C+Rodney+Y&rft.aulast=Chemtob&rft.aufirst=Claude&rft.date=1988-02-01&rft.volume=145&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Psychiatrists; United States of America; Occupational Stress; Practitioner Patient Relationship ER - TY - JOUR T1 - Environmental Aspects of Legionnaires ' Disease AN - 19021189; 8807040 AB - The clinical symptoms of legionnaires ' disease are reviewed, the natural and man-made habitats of Legionella pneumophila are described, and various disinfection methods are evaluated. Although heat rejection devices (cooling towers and evaporative condensers) have been linked to outbreaks of legionnaires ' disease, recent evidence suggests that potable water distribution systems are the primary reservoirs of L. pneumophila. Inhalation of aerosols containing the organism, instillation of the organism into the lung via medical maneuvers of the respiratory tract, and aspiration of contaminated water into the lung are the most likely modes of transmission of L. pneumophila. Treatment methodologies include hyperchlorination, thermal eradication, ozonation, and ultraviolet light irradiation. (Author 's abstract) JF - Journal of the American Water Works Association JAWWA5 Vol. 80, No. 2, p 78-86, February 1988. 9 fig, 79 ref. AU - Muraca, P W AU - Yu, V L AU - Stout, JE AD - Veterans Administration Medical Center Pittsburgh, PA. Special Pathogens Section Y1 - 1988/02// PY - 1988 DA - Feb 1988 KW - Water Resources Abstracts KW - Water treatment KW - Legionella KW - Public health KW - Chlorination KW - Ozonation KW - Cooling towers KW - Water conveyance KW - Human diseases KW - Population exposure KW - Epidemiology KW - Disinfection KW - SW 3060:Water treatment and distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19021189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Environmental+Aspects+of+Legionnaires+%27+Disease&rft.au=Muraca%2C+P+W%3BYu%2C+V+L%3BStout%2C+JE&rft.aulast=Muraca&rft.aufirst=P&rft.date=1988-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Crossover from polytherapy to monotherapy in primary generalized epilepsy. AN - 78642056; 3146221 AB - Patients with primary generalized tonic-clonic seizures can obtain equal or superior seizure control and fewer side effects when managed with valproate than when taking multiple antiepileptic drugs. The conversion from polytherapy to valproate monotherapy must be done carefully if side effects and seizure exacerbation are to be avoided. A gradual crossover, often requiring several months, is usually necessary. A well-developed plan and understanding by the patient, coupled with close follow-up, are essential. The major improvement in quality of life that results for the majority of patients after completing such a conversion fully warrants the extra time and effort required. JF - The American journal of medicine AU - Mattson, R H AU - Cramer, J A AD - Epilepsy Center, Veterans Administration Medical Center, West Haven, Connecticut 06516. Y1 - 1988/01/25/ PY - 1988 DA - 1988 Jan 25 SP - 23 EP - 28 VL - 84 IS - 1A SN - 0002-9343, 0002-9343 KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Female KW - Anticonvulsants -- adverse effects KW - Valproic Acid -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Epilepsy -- drug therapy KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78642056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Crossover+from+polytherapy+to+monotherapy+in+primary+generalized+epilepsy.&rft.au=Mattson%2C+R+H%3BCramer%2C+J+A&rft.aulast=Mattson&rft.aufirst=R&rft.date=1988-01-25&rft.volume=84&rft.issue=1A&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures. AN - 78637470; 3146225 AB - Well-controlled prospective studies have shown the benefits of converting treatment for patients with epilepsy from polytherapy to monotherapy. Results of trials with valproate have demonstrated its efficacy as monotherapy in patients with generalized tonic-clonic seizures. Several studies have found no significant differences between valproate and phenytoin and carbamazepine in the treatment of partial seizures. In studies in which patients were diagnosed as having one of the primary generalized epilepsies, the response rate of tonic-clonic seizures to valproate establishes valproate as the drug of choice in the epilepsy syndromes with primary generalized tonic-clonic seizures. JF - The American journal of medicine AU - Wilder, B J AU - Rangel, R J AD - Veterans Administration Medical Center, Neurology Service, Gainesville, Florida 32602. Y1 - 1988/01/25/ PY - 1988 DA - 1988 Jan 25 SP - 7 EP - 13 VL - 84 IS - 1A SN - 0002-9343, 0002-9343 KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Anticonvulsants -- therapeutic use KW - Valproic Acid -- adverse effects KW - Epilepsy -- drug therapy KW - Epilepsy -- classification KW - Valproic Acid -- therapeutic use KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78637470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Review+of+valproate+monotherapy+in+the+treatment+of+generalized+tonic-clonic+seizures.&rft.au=Wilder%2C+B+J%3BRangel%2C+R+J&rft.aulast=Wilder&rft.aufirst=B&rft.date=1988-01-25&rft.volume=84&rft.issue=1A&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Memory impairment in schizophrenic patients with tardive dyskinesia. AN - 78028429; 3334882 AB - Memory functioning was contrasted in 40 schizophrenic patients with and without tardive dyskinesia (TD). Visual and verbal memory tests were used to investigate specific types of impairments. The presence of TD was ascertained using the Abnormal Involuntary Movement Scale (AIMS). TD patients scored significantly lower than non-TD patients on two measures of visual learning, though no differences were found for verbal learning or immediate recall. These results are consistent with previous reports that schizophrenic patients with TD demonstrate impaired cognitive functioning. They also raise the possibility that the neurochemical and structural changes underlying TD may produce specific deficits in memory for visual materials. In addition, a significant relationship was found between total score on the Brief Psychiatric Rating Scale (BPRS) and performance on all of the test measures included in the cognitive test battery. This demonstrates the importance of attending to the overall level of schizophrenic symptomatology when evaluating results from experimental learning tasks. JF - Biological psychiatry AU - Sorokin, J E AU - Giordani, B AU - Mohs, R C AU - Losonczy, M F AU - Davidson, M AU - Siever, L J AU - Ryan, T A AU - Davis, K L AD - Psychiatry Service, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988/01/15/ PY - 1988 DA - 1988 Jan 15 SP - 129 EP - 135 VL - 23 IS - 2 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Humans KW - Male KW - Dyskinesia, Drug-Induced -- psychology KW - Schizophrenic Psychology KW - Memory Disorders -- complications KW - Schizophrenia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78028429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Memory+impairment+in+schizophrenic+patients+with+tardive+dyskinesia.&rft.au=Sorokin%2C+J+E%3BGiordani%2C+B%3BMohs%2C+R+C%3BLosonczy%2C+M+F%3BDavidson%2C+M%3BSiever%2C+L+J%3BRyan%2C+T+A%3BDavis%2C+K+L&rft.aulast=Sorokin&rft.aufirst=J&rft.date=1988-01-15&rft.volume=23&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of peroxidase inhibitors on an in vivo metabolite of the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats. AN - 78016755; 3121171 AB - Peroxidase metabolism of 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) was evaluated in vitro and in vivo. In vitro metabolism of ANFT was characteristic of the hydroperoxidase activity of prostaglandin H synthase. The peroxidase inhibitors, 6-n-propyl-2-thiouracil and methimazole, significantly reduced ANFT binding to trichloroacetic acid precipitable material and glutathione conjugate formation. Isolated perfused kidneys rapidly converted the glutathione conjugate to its corresponding mercapturic acid (ANFT-MA). With both radiochemical and electrochemical techniques, ANFT-MA was identified in the urine of rats given N-[14C]-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide, the carcinogenic N-formyl analogue of ANFT. ANFT was the major urinary metabolite with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide not detected. A 30-min pretreatment with 6-n-propyl-2-thiouracil and methimazole significantly reduced urinary excretion of ANFT-MA in rats given N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (150 mg/kg) from 14.8 +/- 2.1 (SE) to 7.9 +/- 0.8 and 6.2 +/- 1.1 nmol/18 h, respectively. Peroxidase inhibitor pretreatment did not alter the excretion of ANFT or prostaglandin E2. These results provide further in vitro and in vivo support for the involvement of peroxidases, i.e., the hydroperoxidase activity of prostaglandin H synthase, in ANFT metabolism. JF - Cancer research AU - Rice, J R AU - Spry, L A AU - Zenser, T V AU - Davis, B B AD - Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St. Louis, Missouri 63125. Y1 - 1988/01/15/ PY - 1988 DA - 1988 Jan 15 SP - 304 EP - 309 VL - 48 IS - 2 SN - 0008-5472, 0008-5472 KW - Carcinogens KW - 0 KW - Thiazoles KW - ANFT KW - 38514-71-5 KW - Methimazole KW - 554Z48XN5E KW - Propylthiouracil KW - 721M9407IY KW - FANFT KW - 7N99PZG62O KW - Peroxidases KW - EC 1.11.1.- KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Glutathione KW - GAN16C9B8O KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Glutathione -- metabolism KW - Acetylcysteine -- metabolism KW - Male KW - Urinary Bladder Neoplasms -- chemically induced KW - Peroxidases -- antagonists & inhibitors KW - Carcinogens -- metabolism KW - Thiazoles -- metabolism KW - FANFT -- analogs & derivatives KW - FANFT -- metabolism KW - Propylthiouracil -- pharmacology KW - Methimazole -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78016755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Effect+of+peroxidase+inhibitors+on+an+in+vivo+metabolite+of+the+urinary+bladder+carcinogen+N-%5B4-%285-nitro-2-furyl%29-2-thiazolyl%5Dformamide+in+rats.&rft.au=Rice%2C+J+R%3BSpry%2C+L+A%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Rice&rft.aufirst=J&rft.date=1988-01-15&rft.volume=48&rft.issue=2&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Imaging local cerebral blood flow by Xenon-enhanced computed tomography--technical optimization procedures. AN - 85260284; pmid-3173669 AB - Methods are described for non-invasive, computer-assisted serial scanning throughout the human brain during eight minutes of inhalation of 27%-30% Xenon gas in order to measure local cerebral blood flow (LCBF). Optimized Xenon-enhanced computed tomography (XeCT) was achieved by 5-second scanning at one-minute intervals utilizing a state-of-the-art CT scanner and rapid delivery of Xenon gas via a face mask. Values for local brain-blood partition coefficients (L lambda) measured in vivo were utilized to calculate LCBF values. Previous methods assumed L lambda values to be normal, introducing the risk of systematic errors, because L lambda values differ throughout normal brain and may be altered by disease. Color-coded maps of L lambda and LCBF values were formatted directly onto CT images for exact correlation of function with anatomic and pathologic observations (spatial resolution: 26.5 cubic mm). Results were compared among eight normal volunteers, aged between 50 and 88 years. Mean cortical gray matter blood flow was 46.3 +/- 7.7, for subcortical gray matter was 50.3 +/- 13.2 and for white matter was 18.8 +/- 3.2. Modern CT scanners provide stability, improved signal to noise ratio and minimal radiation scatter. Combining these advantages with rapid Xenon saturation of the blood provides correlations of L lambda and LCBF with images of normal and abnormal brain in a safe, useful and non-invasive manner. JF - Neuroradiology AU - Meyer, J S AU - Shinohara, T AU - Imai, A AU - Kobari, M AU - Sakai, F AU - Hata, T AU - Oravez, W T AU - Timpe, G M AU - Deville, T AU - Solomon, E AD - Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, Houston, Texas. PY - 1988 SP - 283 EP - 292 VL - 30 IS - 4 SN - 0028-3940, 0028-3940 KW - Xenon KW - Gases KW - Aged, 80 and over KW - Human KW - Tomography, X-Ray Computed KW - Brain KW - Support, U.S. Gov't, Non-P.H.S. KW - Support, Non-U.S. Gov't KW - Middle Age KW - Aged KW - Male KW - Female KW - Cerebrovascular Circulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85260284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroradiology&rft.atitle=Imaging+local+cerebral+blood+flow+by+Xenon-enhanced+computed+tomography--technical+optimization+procedures.&rft.au=Meyer%2C+J+S%3BShinohara%2C+T%3BImai%2C+A%3BKobari%2C+M%3BSakai%2C+F%3BHata%2C+T%3BOravez%2C+W+T%3BTimpe%2C+G+M%3BDeville%2C+T%3BSolomon%2C+E&rft.aulast=Meyer&rft.aufirst=J&rft.date=1988-01-01&rft.volume=30&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Neuroradiology&rft.issn=00283940&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visible persistence in paranoid schizophrenics. AN - 85248957; pmid-3337852 AB - A visual temporal integration (i.e., visible persistence) task was performed by normal controls and paranoid schizophrenics. The task evaluated the critical duration (CD), which approximates the duration of peripheral persistence duration and post-CD persistence, which is possibly more associated with central processes. Subjects were required to report when temporally modulated spatial frequency patterns, which are known to have characteristic temporal processing rates, were pulsing "on-off" with a distinct "off" period. The dependent measure was the duration of visible persistence. An analysis of groups X spatial frequency duration (50, 75, 150, 300 msec) X spatial frequency (high, medium, low), with repeated measures on the last two variables, revealed that the second-order interaction was significant (p less than 0.05). Schizophrenics had shorter visible persistence only for the 300-msec presentation for the high spatial frequency pattern. Also, the CD of schizophrenics did not conform to the duration of normals on the high spatial frequency. The results are discussed in terms of the role high spatial frequencies plays in visual information processing and how shorter visible persistence by paranoid schizophrenics may reflect a premature termination of information necessary for synthesis into accurate percepts. JF - Biological Psychiatry AU - Schwartz, B D AU - Winstead, D K AD - Veterans Administration Medical Center, New Orleans, LA 70146. PY - 1988 SP - 3 EP - 12 VL - 23 IS - 1 SN - 0006-3223, 0006-3223 KW - Schizophrenia, Paranoid KW - Human KW - Adult KW - Middle Age KW - Adolescent KW - Attention KW - Sensory Thresholds KW - Memory KW - Form Perception KW - Pattern Recognition, Visual KW - Flicker Fusion KW - Mental Recall UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85248957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Visible+persistence+in+paranoid+schizophrenics.&rft.au=Schwartz%2C+B+D%3BWinstead%2C+D+K&rft.aulast=Schwartz&rft.aufirst=B&rft.date=1988-01-01&rft.volume=23&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Construct validity of the Denman Memory for Human Faces test. AN - 85248597; pmid-3356507 AB - Assessed the validity of the Denman Memory for Human Faces (MHF) subtest employing a clinical sample. Factor analysis with marker variables was employed to establish the nature of the extracted factors. The MHF subtest, WAIS-R Verbal (i.e., Information, Vocabulary, and Digit Span) and Performance (i.e., Block Design and Object Assembly) subtests, the Wechsler Memory Scale Mental Control, Paired Associate Learning, 30-min Logical Memory, and 30-min Visual Reproduction, and Benton's Facial Recognition Test were subjected to a maximum likelihood factoring procedure with Varimax rotation. Four factors were extracted which accounted for 72.7% of the variance. Factor I was perceptual-organization, Factor II was verbal comprehension, Factor III was general memory, and Factor IV was attention-concentration. The MHF subtest achieved a substantial loading (i.e., 0.56) on the general memory factor along with Logical Memory (0.54), Visual Reproduction (0.51), and Paired Associate Learning (0.71). Clinical applications of the MHF were discussed. JF - The International Journal of Neuroscience AU - Ryan, J J AU - Geisser, M E AU - Dalton, J E AD - Veterans Administration Medical Center, Leavenworth, Kansas 66048. PY - 1988 SP - 89 EP - 95 VL - 38 IS - 1-2 SN - 0020-7454, 0020-7454 KW - Verbal Learning KW - Human KW - Adult KW - Middle Age KW - Female KW - Male KW - Memory KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85248597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+Neuroscience&rft.atitle=Construct+validity+of+the+Denman+Memory+for+Human+Faces+test.&rft.au=Ryan%2C+J+J%3BGeisser%2C+M+E%3BDalton%2C+J+E&rft.aulast=Ryan&rft.aufirst=J&rft.date=1988-01-01&rft.volume=38&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+Neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Ultrasonographic findings with bleeding and nonbleeding esophageal varices. AN - 85213672; pmid-3276151 AB - Real time ultrasonography was carried out in 49 cirrhotic patients within 10 days of esophagoscopy, and in 20 normal subjects. Among the cirrhotic patients, 42 had varices and 18 of these had hematemesis within 3 months of study. The varices were graded 0 to 4+ endoscopically; the diameter of the portal vein, the splenic vein, the hepatic artery, and the maximal length of the spleen were determined on ultrasound. In addition, portal collateral veins and the sudden amputation of portal vein branches in the liver were identified when present. There was a significant correlation of the diameter of the portal vein and the maximal spleen length with the magnitude of varices on endoscopy; there was no significant relationship between the splenic vein or the hepatic artery diameter. Less than half the patients with varices had sonographically demonstrated collaterals or portal vein branch amputation. A sonoscore was derived allotting one point each for enlarged portal vein (greater than 1.3 cm), enlarged spleen, collaterals or two or more amputated veins. The sonoscore correlated better with the endoscopic grade of varices than any other marker. The sonoscore among the patients with varices who bled was significantly higher (p less than 0.01) than any of the other measures. It is concluded that real time ultrasound can be used to screen for varices and to identify the need for endoscopy. JF - The American Journal of Gastroenterology AU - Medhat, A AU - Iber, F L AU - Dunne, M AU - Baum, R AD - Department of Gastroenterology, Veterans Administration Medical Center, Baltimore, Maryland. PY - 1988 SP - 58 EP - 63 VL - 83 IS - 1 SN - 0002-9270, 0002-9270 KW - Hepatic Artery KW - Splenic Vein KW - Human KW - Esophageal and Gastric Varices KW - Gastrointestinal Hemorrhage KW - Middle Age KW - Spleen KW - Portal Vein KW - Collateral Circulation KW - Liver Cirrhosis, Alcoholic KW - Esophagoscopy KW - Male KW - Ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Ultrasonographic+findings+with+bleeding+and+nonbleeding+esophageal+varices.&rft.au=Medhat%2C+A%3BIber%2C+F+L%3BDunne%2C+M%3BBaum%2C+R&rft.aulast=Medhat&rft.aufirst=A&rft.date=1988-01-01&rft.volume=83&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin. AN - 85213220; pmid-2892392 AB - The effect of nizatidine, a new histamine H2 receptor antagonist, on gastric secretory function of eight normal subjects stimulated with betazole, was compared with that of cimetidine. Single oral doses of 75 mg, 150 mg, and 300 mg nizatidine, 300 mg cimetidine, and a placebo were administered on separate occasions 1 h before betazole stimulation. Gastric secretions were recovered in 15-min fractions for the ensuing 2 h, and the pH, H+ concentration and output, volume, and pepsin concentration and output were determined. Doses of 150 mg and 300 mg nizatidine depressed the secretory response significantly more than did cimetidine. The antisecretory effects of 75 mg nizatidine was no different than that of 300 mg cimetidine. Nizatidine 300 mg inhibited pepsin output significantly more than volume. Although pepsin concentration was reduced more than volume, the difference was not significant. These observations, in contrast to results of previous studies, suggest a direct inhibition of pepsin secretion, although to a lesser extent than that of acid. JF - The American Journal of Gastroenterology AU - Hammond, J B AU - Offen, W W AD - Gastroenterology Section, Veterans Administration Medical Center North Chicago, Illinois. PY - 1988 SP - 32 EP - 36 VL - 83 IS - 1 SN - 0002-9270, 0002-9270 KW - Betazole KW - Pyrazoles KW - Double-Blind Method KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Thiazoles KW - Gastric Juice KW - Human KW - Hydrogen-Ion Concentration KW - Pepsin A KW - Nizatidine KW - Aged KW - Histamine H2 Antagonists KW - Comparative Study KW - Gastric Acid KW - Adult KW - Middle Age KW - Support, Non-U.S. Gov't KW - Body Water KW - Cimetidine KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Effect+of+nizatidine+and+cimetidine+on+betazole-stimulated+gastric+secretion+of+normal+subjects%3A+comparison+of+effects+on+acid%2C+water%2C+and+pepsin.&rft.au=Hammond%2C+J+B%3BOffen%2C+W+W&rft.aulast=Hammond&rft.aufirst=J&rft.date=1988-01-01&rft.volume=83&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - ERPs to stimuli requiring response production and inhibition: effects of age, probability and visual noise. AN - 85163594; pmid-2446846 AB - Sixty-six normal adults ranging in age from 20 to 85 years were presented with stimuli containing explicit instructions to initiate or to inhibit a motor response (the words 'push' or 'wait'). In one task, the effect of stimulus probability was investigated by varying probability between 0.25 and 0.75 for both Go and No-go stimuli. In another task, the effect of visual noise was investigated by degrading the stimuli with ampersands on half of the trials. Regression analysis was used to examine the effects of age on P3 amplitude and latency for each stimulus type. The effects of stimulus variables on P3, independent of age, were examined by standardizing each subject's data to those expected for a 20 year old. P3 latency to all stimuli and RT to Go stimuli increased with age. The latency of P3s to No-go stimuli was less sensitive to age than Go stimuli. P3 amplitude at Cz and Pz (but not Fz) diminished with age. P3s to Go stimuli were maximal at Pz and earlier than P3s to No-go stimuli. P3s to No-go stimuli were maximal at Cz. These differences between Go and No-go stimuli remained true under visual noise and probability manipulations. Visual noise prolonged the latency of Go and No-go P3. Less probable Go and No-go stimuli elicited larger and later P3s than more probable stimuli. Decreasing the probability of the No-go stimulus enhanced its central distribution. JF - Electroencephalography and Clinical Neurophysiology AU - Pfefferbaum, A AU - Ford, J M AD - Veterans Administration Medical Center, Palo Alto, CA 94304.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA. PY - 1988 SP - 55 EP - 63 VL - 71 IS - 1 SN - 0013-4694, 0013-4694 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85163594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electroencephalography+and+Clinical+Neurophysiology&rft.atitle=ERPs+to+stimuli+requiring+response+production+and+inhibition%3A+effects+of+age%2C+probability+and+visual+noise.&rft.au=Pfefferbaum%2C+A%3BFord%2C+J+M&rft.aulast=Pfefferbaum&rft.aufirst=A&rft.date=1988-01-01&rft.volume=71&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Electroencephalography+and+Clinical+Neurophysiology&rft.issn=00134694&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - N-alkyl-N-dithiocarboxy-D-glucamine analogs as cadmium antagonists: synthesis and evaluation of the n-propyl, n-butyl, and n-amyl derivatives. AN - 78771687; 3250373 AB - N-(n-Propyl)-, N-(n-butyl)-, and N-(n-amyl)-N-dithiocarboxy-D-glucamine were newly synthesized by (a) addition of each n-alkylamine to glucose, (b) high-pressure catalytic reduction of each glucosamine thus formed to the corresponding glucamine, and (c) reaction of the resultant secondary amines with CS2 to form the dithiocarboxy derivatives. Each compound was evaluated as an antagonist of acute cadmium (Cd) toxicity and as a complexing agent for intracellular metallothionein-bound Cd (Cd-MT) in mice. N-Benzyl-N-dithiocarboxy-D-glucamine (BDCG) was used as a positive control compound. Each congener afforded partial or complete protection against the lethal effects of 10.0 mg/kg CdCl2.2.5 H2O, and retarded accumulation of Cd in livers and kidneys when given 2 h after the acutely toxic dose of Cd. Each derivative was also effective in mobilizing Cd from MT-bound sites in livers and kidneys of mice which had received a sub-lethal dose of CdCl2 along with 109CdCl2 2 weeks earlier. Excretion of mobilized Cd was almost exclusively by the fecal route. Potency of the analogs, as well as the octanol/aqueous partition coefficients, increased with the overall length of the N-(n-alkyl) carbon chain. Each compound readily complexed Cd from partially purified Cd-MT in vitro. Serum Cd from mice treated with BDCG was associated principally with proteins of high molecular weight. JF - Archives of toxicology AU - Gale, G R AU - Atkins, L M AU - Smith, A B AU - Jones, S G AU - Basinger, M A AU - Jones, M M AD - Veterans Administration Medical Center, Charleston, South Carolina 29403. Y1 - 1988 PY - 1988 DA - 1988 SP - 428 EP - 434 VL - 62 IS - 6 SN - 0340-5761, 0340-5761 KW - Thiocarbamates KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Sorbitol KW - 506T60A25R KW - Meglumine KW - 6HG8UB2MUY KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Solubility KW - Chemistry KW - Metallothionein -- blood KW - Chemistry, Physical KW - Dose-Response Relationship, Drug KW - Mice KW - Tissue Distribution KW - Body Weight -- drug effects KW - Chemical Phenomena KW - Male KW - Metallothionein -- metabolism KW - Organ Size -- drug effects KW - Meglumine -- chemical synthesis KW - Thiocarbamates -- chemical synthesis KW - Sorbitol -- analogs & derivatives KW - Meglumine -- analogs & derivatives KW - Cadmium -- toxicity KW - Thiocarbamates -- pharmacology KW - Cadmium -- blood KW - Meglumine -- pharmacology KW - Cadmium -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78771687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=N-alkyl-N-dithiocarboxy-D-glucamine+analogs+as+cadmium+antagonists%3A+synthesis+and+evaluation+of+the+n-propyl%2C+n-butyl%2C+and+n-amyl+derivatives.&rft.au=Gale%2C+G+R%3BAtkins%2C+L+M%3BSmith%2C+A+B%3BJones%2C+S+G%3BBasinger%2C+M+A%3BJones%2C+M+M&rft.aulast=Gale&rft.aufirst=G&rft.date=1988-01-01&rft.volume=62&rft.issue=6&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-10 N1 - Date created - 1989-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aspects of compliance: taking drugs and keeping clinic appointments. AN - 78742341; 3149579 AB - Treatment of epilepsy depends on adherence to a drug regimen as prescribed and periodic assessment of progress. Typical problems of compliance to medication and adherence to follow-up in long-term epilepsy treatment in a clinical trial were analyzed. Zero drug levels, subtherapeutic levels, variable levels and delayed dose were measures of non-compliance to the drug regimen. Missed visits and non-drug-related dropouts from the study marked non-adherence. Data from 622 patients participating in a multicenter evaluation of the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin and primidone, showed generally good compliance. Only 5% of patients had zero drug levels or greater than or equal to 24 h since prior dose at 2 or more visits. Good adherence to the protocol was demonstrated by 93% attendance as scheduled. The support structure of the study and the availability of a study assistant helped many patients to prevent potential problems and convert patients into excellent adherers. JF - Epilepsy research. Supplement AU - Mattson, R H AU - Cramer, J A AU - Collins, J F AD - Epilepsy Center, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1988 PY - 1988 DA - 1988 SP - 111 EP - 117 VL - 1 SN - 0922-9833, 0922-9833 KW - Anticonvulsants KW - 0 KW - Primidone KW - 13AFD7670Q KW - Carbamazepine KW - 33CM23913M KW - Phenytoin KW - 6158TKW0C5 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Multicenter Studies as Topic KW - Double-Blind Method KW - Humans KW - Epilepsies, Partial -- drug therapy KW - Clinical Trials as Topic KW - Carbamazepine -- therapeutic use KW - Phenobarbital -- blood KW - Primidone -- blood KW - Prospective Studies KW - Phenytoin -- therapeutic use KW - Carbamazepine -- blood KW - Adult KW - Phenytoin -- blood KW - Epilepsies, Partial -- psychology KW - Middle Aged KW - Adolescent KW - Primidone -- therapeutic use KW - Phenobarbital -- therapeutic use KW - Female KW - Male KW - Patient Compliance KW - Epilepsy -- psychology KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Appointments and Schedules KW - Anticonvulsants -- blood KW - Outpatient Clinics, Hospital UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78742341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research.+Supplement&rft.atitle=Aspects+of+compliance%3A+taking+drugs+and+keeping+clinic+appointments.&rft.au=Mattson%2C+R+H%3BCramer%2C+J+A%3BCollins%2C+J+F&rft.aulast=Mattson&rft.aufirst=R&rft.date=1988-01-01&rft.volume=1&rft.issue=&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research.+Supplement&rft.issn=09229833&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-01 N1 - Date created - 1989-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prolonged calcium channel blocker therapy of hypertension. AN - 78739036; 2468864 AB - The dihydropyridine calcium channel blocker nitrendipine was studied in 329 hypertensive patients at 12 separate centers for periods of 1 year or more. Patients with untreated supine diastolic blood pressures greater than 90 mm Hg were given nitrendipine 5 mg twice daily for 1 week; if the goal blood pressure was not achieved (supine diastolic blood pressure less than 90 mm Hg with a fall of at least 10 mm Hg), the dose was doubled, and if necessary it was doubled again after an additional week. By the end of titration, the goal blood pressure had been achieved in 138 patients (44%). During the subsequent 11 months of study, 155 patients continued to take nitrendipine alone; their posttitration supine diastolic blood pressure was 85 +/- 7 mm Hg, and at the end of the 1 year study it was 84 +/- 6 mm Hg. There were no significant changes in body weight or in heart rate. At their discretion, investigators could add other antihypertensive agents in patients not responding adequately to nitrendipine alone. In 41 patients with a supine diastolic blood pressure of 95 +/- 9 mm Hg after initial titration, propranolol was added to the nitrendipine and decreased the supine diastolic blood pressure to 88 +/- 8 mm Hg by the end of the study; and in another 76 patients with a posttitration supine diastolic blood pressure of 92 +/- 7 mm Hg, the addition of hydrochlorothiazide decreased the supine diastolic blood pressure to 86 +/- 7 mm Hg by the end of the study.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of cardiovascular pharmacology AU - Weber, M A AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1988 PY - 1988 DA - 1988 SP - S16 EP - S21 VL - 12 Suppl 4 SN - 0160-2446, 0160-2446 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Nitrendipine KW - 9B627AW319 KW - Propranolol KW - 9Y8NXQ24VQ KW - Index Medicus KW - Propranolol -- therapeutic use KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Hydrochlorothiazide -- therapeutic use KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Nitrendipine -- therapeutic use KW - Nitrendipine -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78739036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Prolonged+calcium+channel+blocker+therapy+of+hypertension.&rft.au=Weber%2C+M+A&rft.aulast=Weber&rft.aufirst=M&rft.date=1988-01-01&rft.volume=12+Suppl+4&rft.issue=&rft.spage=S16&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-05 N1 - Date created - 1989-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased vitamin A in esophagus and lungs after moderate ethanol consumption. AN - 78729993; 3240708 AB - Moderate ethanol consumption, at the level of 18% of total energy as part of a liquid diet, was found to result in a significant increase of total vitamin A content in the esophageal mucosa in rats fed normal-zinc-containing or zinc-supplemented diets. There was also an increase in total vitamin A content in the lungs after ethanol consumption, but the change was significant only in the zinc-supplemented group. In the liver, retinyl palmitate plus oleate decreased after ethanol, whereas free retinol, retinyl stearate, and linoleate increased. Ethanol consumption resulted in a modest decrease in hepatic zinc content when expressed per gram of liver, but not per total liver (per 100 gram of body weight). Although chronic ethanol consumption at the level of 18% of total energy did not affect total hepatic vitamin A, there was still a significant increase of vitamin A content in esophagus and lungs. JF - Drug-nutrient interactions AU - Leo, M A AU - Kim, C I AU - Lieber, C S AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, Mount Sinai School of Medicine (CUNY), Bronx 10468. Y1 - 1988 PY - 1988 DA - 1988 SP - 227 EP - 236 VL - 5 IS - 4 SN - 0272-3530, 0272-3530 KW - Vitamin A KW - 11103-57-4 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Rats KW - Animals KW - Zinc -- administration & dosage KW - Zinc -- metabolism KW - Liver -- metabolism KW - Tissue Distribution KW - Male KW - Esophagus -- metabolism KW - Alcoholism -- metabolism KW - Vitamin A -- metabolism KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78729993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug-nutrient+interactions&rft.atitle=Increased+vitamin+A+in+esophagus+and+lungs+after+moderate+ethanol+consumption.&rft.au=Leo%2C+M+A%3BKim%2C+C+I%3BLieber%2C+C+S&rft.aulast=Leo&rft.aufirst=M&rft.date=1988-01-01&rft.volume=5&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Drug-nutrient+interactions&rft.issn=02723530&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-18 N1 - Date created - 1989-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium metabolism and bombesin-stimulated pancreatic enzyme secretion. AN - 78726776; 2467597 AB - In dispersed guinea pig pancreatic acini, bombesin stimulates a rapid increase in the concentration of free cytosolic Ca2+ ([Ca2+]i) by releasing Ca2+ from an intracellular agonist-sensitive pool. This increase is transient, and it mediates the initial secretion of digestive enzymes from the acinar cell. During sustained bombesin stimulation, [Ca2+]i returns to the resting or near-resting level, but bombesin-stimulated enzyme secretion continues. Although [Ca2+]i is at the resting level during continued stimulation, 45Ca2+ flux measurements indicate that bombesin continues to release Ca2+ from an intracellular store that is probably the agonist-sensitive pool. Low concentrations (0.3 microM) of the non-fluorescent Ca2+ ionophore, 4-bromo-A23187 (Br-A23187), release Ca2+ from the agonist-sensitive pool without measurably increasing [Ca2+]i. This ionophore-induced Ca2+ release without production of an increase in [Ca2+]i does not by itself stimulate enzyme secretion, but it does augment the secretion caused by the phorbol ester, 4 beta-phorbol, 12-myristate, 13-acetate (PMA). These results suggest a role for intracellular Ca2+ release in bombesin-stimulated sustained secretion. JF - Annals of the New York Academy of Sciences AU - Pandol, S J AU - Mendius, K E AD - Department of Medicine, Veterans Administration Medical Center, San Diego, California. Y1 - 1988 PY - 1988 DA - 1988 SP - 268 EP - 276 VL - 547 SN - 0077-8923, 0077-8923 KW - Benzofurans KW - 0 KW - Calcimycin KW - 37H9VM9WZL KW - Amylases KW - EC 3.2.1.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Bombesin KW - PX9AZU7QPK KW - Calcium KW - SY7Q814VUP KW - Fura-2 KW - TSN3DL106G KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Kinetics KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Calcimycin -- pharmacology KW - Calcium -- metabolism KW - Pancreas -- metabolism KW - Bombesin -- pharmacology KW - Amylases -- secretion KW - Pancreas -- drug effects KW - Pancreas -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78726776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Calcium+metabolism+and+bombesin-stimulated+pancreatic+enzyme+secretion.&rft.au=Pandol%2C+S+J%3BMendius%2C+K+E&rft.aulast=Pandol&rft.aufirst=S&rft.date=1988-01-01&rft.volume=547&rft.issue=&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-03 N1 - Date created - 1989-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholic and spouse concordance on attributions about relapse to drinking. AN - 78716170; 3236390 AB - The purpose of this paper is to report a descriptive study of the degree of concordance between male alcoholics' and their wives' perceptions of the alcoholics' relapse to drinking within two years of their participation in an outcome study of behavioral marital therapy for alcoholism. At the end of a two-year follow-up period, the 23 alcoholics who had relapsed and their wives were independently interviewed. The results showed that both the alcoholics and their spouses reported both intrapsychic and situational determinants of the relapses. Among types of determinants, the situational spouse was reported disproportunately more often by patients and disproportunately less often by spouses. Furthermore, the concordance between patient and spouse reports was low. Use of these findings for marital therapy in the treatment of alcohol abuse is discussed. JF - Journal of substance abuse treatment AU - Maisto, S A AU - O'Farrell, T J AU - McKay, J R AU - Connors, G J AU - Pelcovits, M AD - Veterans Administration Medical Center, Brockton, Massachusetts. Y1 - 1988 PY - 1988 DA - 1988 SP - 179 EP - 181 VL - 5 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Behavior Therapy KW - Humans KW - Recurrence KW - Male KW - Female KW - Alcoholism -- therapy KW - Marriage KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78716170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Alcoholic+and+spouse+concordance+on+attributions+about+relapse+to+drinking.&rft.au=Maisto%2C+S+A%3BO%27Farrell%2C+T+J%3BMcKay%2C+J+R%3BConnors%2C+G+J%3BPelcovits%2C+M&rft.aulast=Maisto&rft.aufirst=S&rft.date=1988-01-01&rft.volume=5&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-08 N1 - Date created - 1989-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension. AN - 78711891; 2467140 AB - Amlodipine, a new long-acting dihydropyridine calcium antagonist, was compared with hydrochlorothiazie (HCTZ) in 145 patients with mild to moderate hypertension. After 4 weeks of single-blind placebo runin, patients were randomly allocated to receive amlodipine (2.5-10 mg once daily, n = 97) or HCTZ (25-100 mg once daily, n = 48). At study week 12 response rates for amlodipine and HCTZ were 61.5 and 60.5%, respectively. There were clinically significant reductions in 24-h postdose blood pressures with both amlodipine (-18/-11 mm Hg supine: -14/-10 mm Hg standing) and HCTZ (-18/-10 mm Hg supine, -18/-9 mm Hg standing). After study week 12, atenolol (50-100 mg once daily) was added to the regimen of those patients whose hypertension was not controlled with monotherapy. Neither amlodipine nor HCTZ produced clinically significant changes in pulse rate, electrocardiogram, or chest x-ray film. Although amlodipine increased and HCTZ decreased the high-density lipoprotein (HDL)/total cholesterol ratio and the HDL/(low-density lipoprotein + very-low-density lipoprotein) ratio, the difference between the two treatments was not statistically significant. The incidence of side effects and the rate of patient withdrawal was comparable in the two groups. The incidence of laboratory abnormalities was 56% with HCTZ (mainly hypokalemia and hyperuricemia) and 16% with amlodipine. Amlodipine was an effective, well-tolerated agent for treatment of mild-to-moderate hypertension in this study, as single-daily-dose monotherapy and in combination with atenolol. JF - Journal of cardiovascular pharmacology AU - Burris, J F AU - Ames, R P AU - Applegate, W B AU - Ram, C V AU - Davidov, M E AU - Mroczek, W J AD - Hypertension Research Unit, Veterans Administration Medical Center, Washington, D.C. 20422. Y1 - 1988 PY - 1988 DA - 1988 SP - S98 EP - 102 VL - 12 Suppl 7 SN - 0160-2446, 0160-2446 KW - Calcium Channel Blockers KW - 0 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Amlodipine KW - 1J444QC288 KW - Nifedipine KW - I9ZF7L6G2L KW - Index Medicus KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Nifedipine -- analogs & derivatives KW - Nifedipine -- therapeutic use KW - Calcium Channel Blockers -- adverse effects KW - Nifedipine -- adverse effects KW - Hydrochlorothiazide -- therapeutic use KW - Calcium Channel Blockers -- therapeutic use KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78711891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Double-blind+comparison+of+amlodipine+and+hydrochlorothiazide+in+patients+with+mild+to+moderate+hypertension.&rft.au=Burris%2C+J+F%3BAmes%2C+R+P%3BApplegate%2C+W+B%3BRam%2C+C+V%3BDavidov%2C+M+E%3BMroczek%2C+W+J&rft.aulast=Burris&rft.aufirst=J&rft.date=1988-01-01&rft.volume=12+Suppl+7&rft.issue=&rft.spage=S98&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-11 N1 - Date created - 1989-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retrovirus induced motor neuron degeneration. AN - 78697583; 2852840 AB - Neurotropic retroviruses are capable of infecting and altering the function of dividing populations of neuron-like cells such as the PC-12 cell line. However, histological, immunohistochemical, and ultrastructural studies have failed to implicate direct infection of neurons by MuLV as the etiologic mechanism responsible for MuLV induced neurodegenerative disease. Indirect mechanisms such as the physical or biochemical disruption of endothelial cell basement membranes or the production of toxic cytokines by virus infected cells may play a role in the development of retrovirus induced neurodegeneration. JF - Revue neurologique AU - Hoffman, P M AU - Pitts, O M AU - Bilello, J A AU - Cimino, E F AD - Research Service, Veterans Administration Medical Center, Baltimore, MD 21218. Y1 - 1988 PY - 1988 DA - 1988 SP - 676 EP - 679 VL - 144 IS - 11 SN - 0035-3787, 0035-3787 KW - Index Medicus KW - Animals KW - Mice KW - Motor Neurons -- pathology KW - Nerve Degeneration KW - Motor Neurons -- microbiology KW - Retroviridae Infections -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78697583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revue+neurologique&rft.atitle=Retrovirus+induced+motor+neuron+degeneration.&rft.au=Hoffman%2C+P+M%3BPitts%2C+O+M%3BBilello%2C+J+A%3BCimino%2C+E+F&rft.aulast=Hoffman&rft.aufirst=P&rft.date=1988-01-01&rft.volume=144&rft.issue=11&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Revue+neurologique&rft.issn=00353787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-13 N1 - Date created - 1989-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acetaminophen directly protects human gastric epithelial cell monolayers against damage induced by sodium taurocholate. AN - 78697110; 3234624 AB - The present study evaluated whether acetaminophen can reduce sodium-taurocholate-induced damage to human gastric epithelial cells grown in monolayer culture (a preparation which excludes systemic factors). Further, the role of endogenous prostaglandin production by gastric cells in any such protection has been assessed. Results showed that (1) acetaminophen significantly protects human gastric epithelial cells against taurocholate-induced damage in vitro, in conditions independent of systemic factors, (2) protection of gastric cells by acetaminophen in vitro appears unrelated to stimulation of prostaglandin synthesis, and (3) a direct protective effect on gastric epithelial cells may play a role in protection of gastric mucosa by acetaminophen in vivo. JF - Digestion AU - Romano, M AU - Razandi, M AU - Ivey, K J AD - Department of Medicine, Long Beach Veterans Administration Medical Center, Calif. Y1 - 1988 PY - 1988 DA - 1988 SP - 181 EP - 190 VL - 40 IS - 3 SN - 0012-2823, 0012-2823 KW - Prostaglandins E KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Taurocholic Acid KW - 5E090O0G3Z KW - Dinoprostone KW - K7Q1JQR04M KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Dinoprostone -- pharmacology KW - Epithelial Cells KW - Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Histocytochemistry KW - Prostaglandins E -- physiology KW - Epithelium -- drug effects KW - Indomethacin -- pharmacology KW - Stomach Diseases -- chemically induced KW - Gastric Mucosa -- drug effects KW - Stomach Diseases -- prevention & control KW - Acetaminophen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78697110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestion&rft.atitle=Acetaminophen+directly+protects+human+gastric+epithelial+cell+monolayers+against+damage+induced+by+sodium+taurocholate.&rft.au=Romano%2C+M%3BRazandi%2C+M%3BIvey%2C+K+J&rft.aulast=Romano&rft.aufirst=M&rft.date=1988-01-01&rft.volume=40&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Digestion&rft.issn=00122823&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-26 N1 - Date created - 1989-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Social learning approaches to alcohol relapse: selected illustrations and implications. AN - 78680345; 3147380 JF - NIDA research monograph AU - Monti, P M AU - Rohsenow, D J AU - Abrams, D B AU - Binkoff, J A AD - Inpatient Psychiatry Unit, Brown University/Providence Veterans Administration Medical Center, RI 02908. Y1 - 1988 PY - 1988 DA - 1988 SP - 141 EP - 160 VL - 84 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Social Adjustment KW - Humans KW - Recurrence KW - Adaptation, Psychological KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78680345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Social+learning+approaches+to+alcohol+relapse%3A+selected+illustrations+and+implications.&rft.au=Monti%2C+P+M%3BRohsenow%2C+D+J%3BAbrams%2C+D+B%3BBinkoff%2C+J+A&rft.aulast=Monti&rft.aufirst=P&rft.date=1988-01-01&rft.volume=84&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Closed chamber system for delivery of ethanol to cell cultures. AN - 78673386; 3228458 AB - The accuracy and consistency of the delivery of ethanol to cultured cells is important to determine effects on morphologic, biochemical and physiologic alterations. Open and closed chamber systems were evaluated to determine cytotoxic vs sublethal, potentially teratogenic effects on neonatal rat cardiac myocytes. The open system employed a variety of cell culture vessels. Cardiac cells were exposed directly to ethanol in the growth media at concentrations of 5-50 mM in Petri dishes, multiwell slides and multiwell chambers. Ethanol concentrations in the media in these open vessels decreased over 60% in a 24 hr incubation period. A closed system consisted of tightly sealed plastic containers in which the same vessels were used. The vessels were placed on a platform over a bath of ethanol-water. Cells were acclimated for 24 hr with ethanol in the bath at 200% of the final desired media concentration. Ethanol gradually diffused into the media to reach peak levels of 5, 10, 25 or 50 mM at 24 hr. After the 24 hr period, ethanol was added to both the media and bath at the desired concentration. Cells exposed gradually to ethanol in the closed chambers remained viable, but showed slower division and growth. A period of gradual acclimation is required to induce sublethal cellular effects rather than lethal effects. The diversity of cell systems and manipulations of cultures to study the potential teratogenic effects of ethanol are improved using such a closed chamber system. JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Adickes, E D AU - Mollner, T J AU - Lockwood, S K AD - Research Service (151), Omaha Veterans Administration Hospital, NE 68105. Y1 - 1988 PY - 1988 DA - 1988 SP - 377 EP - 381 VL - 23 IS - 5 SN - 0735-0414, 0735-0414 KW - Culture Media KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cell Count -- drug effects KW - Cells, Cultured KW - In Vitro Techniques KW - Cell Division -- drug effects KW - Cell Differentiation -- drug effects KW - Diffusion Chambers, Culture KW - Ethanol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78673386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Closed+chamber+system+for+delivery+of+ethanol+to+cell+cultures.&rft.au=Adickes%2C+E+D%3BMollner%2C+T+J%3BLockwood%2C+S+K&rft.aulast=Adickes&rft.aufirst=E&rft.date=1988-01-01&rft.volume=23&rft.issue=5&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-14 N1 - Date created - 1989-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathophysiology of alcoholic liver disease. AN - 78670101; 3067024 JF - Molecular aspects of medicine AU - Lieber, C S AD - Section of Liver Disease and Nutrition, Bronx Veterans Administration Medical Center, N.Y. Y1 - 1988 PY - 1988 DA - 1988 SP - 107 EP - 146 VL - 10 IS - 2 SN - 0098-2997, 0098-2997 KW - Xenobiotics KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Xenobiotics -- pharmacokinetics KW - Liver -- pathology KW - Drug Interactions KW - Humans KW - Liver -- metabolism KW - Subcellular Fractions -- metabolism KW - Ethanol -- metabolism KW - Subcellular Fractions -- pathology KW - Liver Diseases, Alcoholic -- metabolism KW - Liver Diseases, Alcoholic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78670101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+aspects+of+medicine&rft.atitle=Pathophysiology+of+alcoholic+liver+disease.&rft.au=Lieber%2C+C+S&rft.aulast=Lieber&rft.aufirst=C&rft.date=1988-01-01&rft.volume=10&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Molecular+aspects+of+medicine&rft.issn=00982997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-05 N1 - Date created - 1989-04-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Mol Aspects Med 1988;10(4):i N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of assessment techniques measuring the effects of methylphenidate, secobarbital, diazepam and diphenhydramine in abstinent alcoholics. AN - 78667890; 3226529 AB - In two studies, we studied the comparative sensitivity of different subjective and objective measures to methylphenidate (10 and 20 mg) and secobarbital (100 mg) versus placebo, and diphenhydramine (50 mg) and diazepam (10 and 20 mg) versus placebo in abstinent alcoholics. Subjective measures used were the Visual Analog Mood Scale and the Profile of Mood States. Objective measures were the Stroop and two microcomputer-controlled tasks developed in our lab - a dual pursuit tracking/reaction time task (P-Trak) and a reaction time task with regular and irregular preparatory intervals (PI) of varying length (Reactest). In addition, several baseline measures (Eysenck Personality Inventory, Spielberger State-Trait Anxiety Inventory and NIMH Mood Scale Elderly) were evaluated for their correlation to drug response. All three central nervous system depressants impaired performance on Reactest at the longer PIs and showed a main effect with irregular PIs, but only the 20-mg dose of diazepam impaired reaction time at the shortest PI and showed a main effect with regular PIs. On P-Trak, secobarbital and diazepam 20 mg impaired both tracking and reaction time, while methylphenidate 20 mg improved only the reaction time component. Only diazepam 20 mg affected mood. No effects were noted on the Stroop. The implications of these findings are discussed. Both P-Trak and Reactest with long PIs were more sensitive than VAMS, POMS or Stroop to drug effects. As lower doses of central nervous system depressants impaired reaction time only with longer PIs and showed a main effect only with irregular PIs, cognitive effects of these drugs may be missed if only subjective or short, regular PI tasks are examined.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Neuropsychobiology AU - Miller, T P AU - Taylor, J L AU - Tinklenberg, J R AD - Laboratory of Clinical Psychopharmacology and Psychophysiology, Veterans Administration Medical Center, Palo Alto, Calif. Y1 - 1988 PY - 1988 DA - 1988 SP - 90 EP - 96 VL - 19 IS - 2 SN - 0302-282X, 0302-282X KW - Secobarbital KW - 1P7H87IN75 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Diphenhydramine KW - 8GTS82S83M KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Discrimination Learning -- drug effects KW - Reaction Time -- drug effects KW - Psychomotor Performance -- drug effects KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Psychological Tests KW - Alcoholism -- rehabilitation KW - Secobarbital -- pharmacology KW - Methylphenidate -- pharmacology KW - Arousal -- drug effects KW - Diphenhydramine -- pharmacology KW - Diazepam -- pharmacology KW - Attention -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78667890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychobiology&rft.atitle=A+comparison+of+assessment+techniques+measuring+the+effects+of+methylphenidate%2C+secobarbital%2C+diazepam+and+diphenhydramine+in+abstinent+alcoholics.&rft.au=Miller%2C+T+P%3BTaylor%2C+J+L%3BTinklenberg%2C+J+R&rft.aulast=Miller&rft.aufirst=T&rft.date=1988-01-01&rft.volume=19&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Neuropsychobiology&rft.issn=0302282X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-05 N1 - Date created - 1989-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase. AN - 78662776; 3224598 AB - A study was made of the evolution of emphysema and airway injury induced in the lungs of male golden Syrian hamsters by a single intratracheal injection of 350 micrograms human neutrophil elastase (HNE). Saline control and HNE-treated groups of 8 animals were studied 1, 3, 6, 12, and 18 months posttreatment. HNE treatment caused a significant increase in all lung volumes and a significant decrease in maximum expiratory flows at all study times. The mean linear intercept (MLI) values of the left lung were significantly increased over control values. There was no progression with time in MLI values, lung volumes, or lung compliance. Secretory-cell metaplasia was present at 1 month and persisted throughout the study. The HNE-treated lungs showed clusters of ferric iron-containing macrophages in the terminal airspaces. The amount of iron in the lungs, determined morphometrically, was greatest at 1 month, was decreased by 6 months, and then did not change further to 18 months. At 18 months the amount of iron was still significantly above control amounts. We conclude that the airway and parenchymal lesions induced by HNE persist without progression for 18 months. Clearance of ferric iron, which was probably a result of the hemorrhage induced by HNE treatment, continued for 6 months with no evident subsequent clearance. JF - Experimental lung research AU - Lucey, E C AU - Stone, P J AU - Christensen, T G AU - Breuer, R AU - Snider, G L AD - Pulmonary Section, Boston Veterans Administration Medical Center, MA 02130. Y1 - 1988 PY - 1988 DA - 1988 SP - 671 EP - 686 VL - 14 IS - 5 SN - 0190-2148, 0190-2148 KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Index Medicus KW - Animals KW - Reference Values KW - Maximal Expiratory Flow Rate KW - Humans KW - Body Weight -- drug effects KW - Mesocricetus KW - Emphysema -- physiopathology KW - Lung Compliance -- drug effects KW - Emphysema -- chemically induced KW - Time Factors KW - Cricetinae KW - Pancreatic Elastase -- toxicity KW - Pancreatic Elastase -- blood KW - Lung -- drug effects KW - Neutrophils -- enzymology KW - Lung -- pathology KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78662776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=An+18-month+study+of+the+effects+on+hamster+lungs+of+intratracheally+administered+human+neutrophil+elastase.&rft.au=Lucey%2C+E+C%3BStone%2C+P+J%3BChristensen%2C+T+G%3BBreuer%2C+R%3BSnider%2C+G+L&rft.aulast=Lucey&rft.aufirst=E&rft.date=1988-01-01&rft.volume=14&rft.issue=5&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-06 N1 - Date created - 1989-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence for tumor reduction in refractory or relapsed B-CLL patients with infusional interleukin-2. AN - 78660413; 3265509 AB - Recombinant interleukin-2 (rIL-2) is a biologic response modifier that is capable of enhancing or restoring the cytolytic capacity of large granular lymphocytes (LGL). We utilized this biologic response modifier in the treatment of B-chronic lymphocytic leukemia (B-CLL), a disease frequently characterized by deficient or absent natural killer activity. B-CLL (n = 12) patients previously refractory to chemotherapy or with progressive disease post cessation of chemotherapy were eligible. rIL-2 was given as i.v. infusion (2 x 10(6) units/m2) over 2 h 5 times per week for 3 weeks as induction. Responding patients were placed on maintenance therapy. Although there were no complete or partial responses (by ECOG criteria) there was clear evidence of tumor reduction. Seven of 10 evaluable patients had a reduction of the peripheral blood B cell clone, 3 had node reduction and 2 had reduction in their splenomegaly. All patients experienced mild to moderate toxicity and 1 patient died while on induction therapy. Three B-CLL patients following induction rIL-2 treatment were placed back on chemotherapy because of progressive disease. Interestingly, these 2 B-CLL patients achieved extremely rapid and complete responses to chemotherapy which had previously been ineffective. These data suggest a possible role for rIL-2 in treatment of B-CLL. JF - Nouvelle revue francaise d'hematologie AU - Kay, N E AU - Oken, M M AU - Mazza, J J AU - Bradley, E C AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN. Y1 - 1988 PY - 1988 DA - 1988 SP - 475 EP - 478 VL - 30 IS - 5-6 KW - Antineoplastic Agents KW - 0 KW - Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Infusions, Intravenous KW - Humans KW - Aged KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Recombinant Proteins -- administration & dosage KW - Male KW - Female KW - Remission Induction KW - Interleukin-2 -- administration & dosage KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Leukemia, Lymphocytic, Chronic, B-Cell -- pathology KW - Spleen -- drug effects KW - Lymph Nodes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78660413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nouvelle+revue+francaise+d%27hematologie&rft.atitle=Evidence+for+tumor+reduction+in+refractory+or+relapsed+B-CLL+patients+with+infusional+interleukin-2.&rft.au=Kay%2C+N+E%3BOken%2C+M+M%3BMazza%2C+J+J%3BBradley%2C+E+C&rft.aulast=Kay&rft.aufirst=N&rft.date=1988-01-01&rft.volume=30&rft.issue=5-6&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Nouvelle+revue+francaise+d%27hematologie&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-16 N1 - Date created - 1989-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effects of dilevalol, metoprolol, and placebo on ventilatory function in asthmatics. AN - 78628032; 2464094 AB - Dilevalol combines a nonselective blocking action on beta-receptors with selective beta 2-agonist activity. In this double-blind, three-way, crossover study, the effects of relatively high single doses of dilevalol (400 mg), metoprolol (200 mg), a placebo on pulmonary function and their interaction with isoproterenol (160 and 480 micrograms) were evaluated in 16 patients with reversible bronchial asthma [isoproterenol-induced increase in forced expiratory volume in 1 s (FEV1) of greater than or equal to 15%]. When the lowest or minimum values observed during the 2 h postdrug evaluation period were considered, there was no significant difference from baseline in the percentage change in FEV1 after placebo (-4.4%) and dilevalol (-10%), with the difference between these treatments not being statistically significant. However, following metoprolol, FEV1 decreased by 18.3%, a decrease significantly different (p less than 0.01), from baseline and from the effects of placebo (p less than 0.01), although not from dilevalol. Furthermore, following metoprolol, 7 of 16 patients (44%) showed a greater than or equal to 20% decrease in FEV1 as compared to only 3 patients (19%) following dilevalol and 1 patient (6%) following placebo. The effects of the three treatments on forced vital capacity (FVC) and maximal midexpiratory flow (MMEF) were qualitatively similar to those observed in FEV1. Both dilevalol and metoprolol similarly and significantly (p less than or equal to 0.01) inhibited the isoproterenol (160 and 480 micrograms) response in FEV1 as compared to placebo.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of cardiovascular pharmacology AU - Chodosh, S AU - Tuck, J AU - Blasucci, D J AD - Veterans Administration Medical Center, Boston, Massachusetts 02108. Y1 - 1988 PY - 1988 DA - 1988 SP - S18 EP - S24 VL - 11 Suppl 2 SN - 0160-2446, 0160-2446 KW - Adrenergic beta-Antagonists KW - 0 KW - Metoprolol KW - GEB06NHM23 KW - Isoproterenol KW - L628TT009W KW - Labetalol KW - R5H8897N95 KW - Index Medicus KW - Respiratory Function Tests KW - Hemodynamics -- drug effects KW - Isoproterenol -- therapeutic use KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Forced Expiratory Volume KW - Adolescent KW - Male KW - Female KW - Metoprolol -- therapeutic use KW - Asthma -- drug therapy KW - Adrenergic beta-Antagonists -- adverse effects KW - Labetalol -- therapeutic use KW - Adrenergic beta-Antagonists -- therapeutic use KW - Labetalol -- adverse effects KW - Asthma -- physiopathology KW - Metoprolol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78628032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=The+effects+of+dilevalol%2C+metoprolol%2C+and+placebo+on+ventilatory+function+in+asthmatics.&rft.au=Chodosh%2C+S%3BTuck%2C+J%3BBlasucci%2C+D+J&rft.aulast=Chodosh&rft.aufirst=S&rft.date=1988-01-01&rft.volume=11+Suppl+2&rft.issue=&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-02 N1 - Date created - 1989-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction between oxygen and cell membranes: modification of membrane lipids to enhance pulmonary artery endothelial cell tolerance to hypoxia. AN - 78610166; 3208730 AB - Because high partial pressures of oxygen (O2) can cause peroxidative cleavage of membrane lipids, it is plausible to hypothesize that hyperoxia alters the physical state and composition of lipids in the membranes of pulmonary endothelial cells and that manipulation of the lipid profile may modify endothelial cell tolerance to hyperoxic injury. To test this, porcine pulmonary artery endothelial cells were exposed to 95% O2 at 1 atmosphere absolute (ATA) in the presence or absence of cis vaccenic acid (CVA), a monounsaturated fatty acid (C18:1#11). Plasma membrane fluidity was assessed by fluorescence spectroscopy, plasma membrane lipid composition was quantitated using thin layer and gas chromatography, and cytotoxicity was monitored by measuring release of lactate dehydrogenase (LDH). Hyperoxia caused peroxidation of membrane lipids and decreased fluidity in three distinct lipid domains within the plasma membrane. Incubation with CVA was associated with a reduction in the degree of unsaturation of the constituent fatty acids within all plasma membrane lipid subclasses except monoglycerides. CVA-treated cells were also more resistant to hyperoxic injury as judged by LDH release. These results support the hypothesis that cells with membranes in which the fatty acyl chains are more resistant to the disordering effects of high O2 tensions may be more resistant to O2 toxicity. JF - Experimental lung research AU - Block, E R AD - Research Service, Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1988 PY - 1988 DA - 1988 SP - 937 EP - 958 VL - 14 Suppl SN - 0190-2148, 0190-2148 KW - Fatty Acids KW - 0 KW - Lipid Peroxides KW - Membrane Lipids KW - Phospholipids KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Swine KW - Animals KW - Lipid Peroxides -- biosynthesis KW - Cells, Cultured KW - Cell Membrane -- drug effects KW - Phospholipids -- metabolism KW - Membrane Fluidity -- drug effects KW - Cell Membrane -- metabolism KW - Models, Biological KW - Fatty Acids -- metabolism KW - Hypoxia -- pathology KW - Pulmonary Artery -- pathology KW - Oxygen -- pharmacology KW - Pulmonary Artery -- physiopathology KW - Membrane Lipids -- metabolism KW - Hypoxia -- metabolism KW - Endothelium, Vascular -- pathology KW - Endothelium, Vascular -- physiopathology KW - Hypoxia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78610166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Interaction+between+oxygen+and+cell+membranes%3A+modification+of+membrane+lipids+to+enhance+pulmonary+artery+endothelial+cell+tolerance+to+hypoxia.&rft.au=Block%2C+E+R&rft.aulast=Block&rft.aufirst=E&rft.date=1988-01-01&rft.volume=14+Suppl&rft.issue=&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung MK 351A uptake after hypoxia adaptation and subsequent hyperoxia exposure. AN - 78593504; 2849698 AB - This study investigated the effects of hypoxia adaptation (10% O2 for 4 days) on rat lung angiotensin-converting enzyme (ACE) content before and after hyperoxia exposure (greater than 95% O2 for 2 days). The rationale for this investigation was that hyperoxia exposure decreases lung ACE, while hypoxia adaptation produces tolerance (improved survival) to oxygen toxicity in rats. Rats were exposed to air, hypoxia, hyperoxia alone, or hypoxia followed immediately by hyperoxia. The lungs were then excised and perfused in vitro at 12 ml/min with buffer. Lung ACE content was quantitated by measuring the single-pass binding of an iodinated ACE inhibitor, 125I-MK 351A, a derivative of lisinopril. We showed previously that 125I-MK 351A binding correlates quantitatively with ACE activity in lung homogenates and isolated, perfused lungs. Lung internal surface area was estimated by measuring the mean alveolar diameter of 5 micron hematoxylin and eosin sections from lungs fixed in inflation (25 cmH2O transpulmonary pressure). Hypoxia adaptation per se had no effect on 125I-MK 351A binding or estimated alveolar surface area, while hyperoxia exposure caused a significant decrease in both 125I-MK 351A binding and alveolar surface area. These hyperoxia-induced decreases were prevented partially by hypoxia adaptation, indicating a protective effect on both ACE content and surface area. 125I-MK 351A binding in isolated perfused lungs changed in parallel with histologically estimated surface area. These results indicate that hypoxia preadaptation minimizes the oxygen-induced decrease in lung microvascular ACE content. JF - Lung AU - Jackson, R M AU - Ann, H S AU - Oparil, S AD - Birmingham Veterans Administration Medical Center, Division of Pulmonary and Critical Care Medicine, AL 35294. Y1 - 1988 PY - 1988 DA - 1988 SP - 209 EP - 219 VL - 166 IS - 4 SN - 0341-2040, 0341-2040 KW - Dipeptides KW - 0 KW - Iodine Radioisotopes KW - L-proline, N2-((1S)-1-carboxy-3-phenylpropyl)-N6-((4-hydroxyphenyl)iminomethyl)-L-lysyl- KW - 0CNN4A598M KW - Peptidyl-Dipeptidase A KW - EC 3.4.15.1 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Peptidyl-Dipeptidase A -- analysis KW - Male KW - Oxygen -- pharmacology KW - Hypoxia -- metabolism KW - Lung -- drug effects KW - Dipeptides -- metabolism KW - Lung -- enzymology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78593504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung&rft.atitle=Lung+MK+351A+uptake+after+hypoxia+adaptation+and+subsequent+hyperoxia+exposure.&rft.au=Jackson%2C+R+M%3BAnn%2C+H+S%3BOparil%2C+S&rft.aulast=Jackson&rft.aufirst=R&rft.date=1988-01-01&rft.volume=166&rft.issue=4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Lung&rft.issn=03412040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-01 N1 - Date created - 1989-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drinking practices among black and white alcoholics and alcoholics of different personality types. AN - 78590418; 3210121 AB - In order to examine the effects that race and personality type have on self-reported drinking practices, samples of 49 White and 49 Black male alcoholics were matched on age and education, and classified into two personality types according to MMPI scores. The results of multivariate and univariate analyses of variance yielded significant main effects. White alcoholics reported a greater: (a) use of alcohol for symptomatic relief of psychological distress, (b) loss of motor control and tendency to engage in destructive acts, and (c) daily consumption of beverage alcohol than Black alcoholics. Alcoholics with psychiatric-appearing MMPI profiles reported greater: (a) social benefits of alcohol use, (b) alcohol use for symptomatic relief of psychological distress, and (c) perceptual distortions associated with alcohol withdrawal than alcoholics with characterlogical-appearing MMPIs. Results were discussed in terms of need to control confounding effects of biosocial variables in cross-cultural research and implications that these effects may have on the generalizability of alcoholic personality typologies. JF - Journal of personality assessment AU - Robyak, J E AU - Prange, M AU - Sands, M AD - Veterans Administration Medical Center, Bay Pines, FL 33504. Y1 - 1988 PY - 1988 DA - 1988 SP - 487 EP - 498 VL - 52 IS - 3 SN - 0022-3891, 0022-3891 KW - Index Medicus KW - Humans KW - Adult KW - Psychometrics KW - Male KW - African Americans -- psychology KW - MMPI KW - European Continental Ancestry Group -- psychology KW - Alcohol Drinking -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78590418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+assessment&rft.atitle=Drinking+practices+among+black+and+white+alcoholics+and+alcoholics+of+different+personality+types.&rft.au=Robyak%2C+J+E%3BPrange%2C+M%3BSands%2C+M&rft.aulast=Robyak&rft.aufirst=J&rft.date=1988-01-01&rft.volume=52&rft.issue=3&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-13 N1 - Date created - 1989-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction between clozapine and a lipophilic alpha 1-adrenergic agonist. AN - 78581067; 2904633 AB - Acute intraperitoneal injection of clozapine produced marked hypothermia and ataxia in Swiss-Webster mice. These two effects were almost completely blocked by the lipophilic alpha 1-adrenergic agonist, St 587, but not by the peripherally-acting alpha 1 agonist methoxamine. It was inferred that these effects of clozapine are central in origin and probably resulted from alpha 1 adrenergic blockade. However, since prazosin, a selective alpha 1-adrenergic antagonist did not elicit either hypothermia or ataxia in mice it became clear that the alpha 1 adrenergic blocking effect of clozapine is not entirely responsible for these effects, but has a major contributory role in their production. Both clozapine and prazosin inhibited the d-amphetamine-induced locomotor stimulation in mice. St 587 did not significantly reduce this amphetamine-blocking effect of clozapine. It was inferred that this response to d-amphetamine involving the release of mesolimbic dopamine is distinct from the other two St 587-sensitive responses. The hypothermic and ataxic effects of clozapine developed complete tolerance after just four days of treatment, but ten days of such treatment was required for the development of tolerance to the amphetamine-blocking effect of clozapine. The possible relationships between St 587-sensitive and insensitive effects of clozapine and its antipsychotic property are discussed. JF - Life sciences AU - Menon, M K AU - Gordon, L I AU - Fitten, J AD - Psychopharmacology Research Laboratory, Veterans Administration Medical Center, Sepulveda, California 91343. Y1 - 1988 PY - 1988 DA - 1988 SP - 1791 EP - 1804 VL - 43 IS - 22 SN - 0024-3205, 0024-3205 KW - Adrenergic alpha-Agonists KW - 0 KW - Dibenzazepines KW - St 587 KW - 15327-38-5 KW - Methoxamine KW - HUQ1KC1YLI KW - Clozapine KW - J60AR2IKIC KW - Clonidine KW - MN3L5RMN02 KW - Dextroamphetamine KW - TZ47U051FI KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Methoxamine -- pharmacology KW - Drug Tolerance KW - Animals KW - Drug Interactions KW - Body Temperature -- drug effects KW - Prazosin -- pharmacology KW - Motor Activity -- drug effects KW - Mice KW - Male KW - Dextroamphetamine -- pharmacology KW - Clozapine -- administration & dosage KW - Adrenergic alpha-Agonists -- pharmacology KW - Clonidine -- analogs & derivatives KW - Clozapine -- pharmacology KW - Clonidine -- pharmacology KW - Dibenzazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78581067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Interaction+between+clozapine+and+a+lipophilic+alpha+1-adrenergic+agonist.&rft.au=Menon%2C+M+K%3BGordon%2C+L+I%3BFitten%2C+J&rft.aulast=Menon&rft.aufirst=M&rft.date=1988-01-01&rft.volume=43&rft.issue=22&rft.spage=1791&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-19 N1 - Date created - 1989-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms. AN - 78571899; 2904696 AB - One of the major problems associated with long-term neuroleptic treatment is persistent tardive dyskinesia (TD), for which there is no satisfactory treatment. We have recently proposed that some cases of TD are associated with neuronal dysfunction resulting from excess free radical production occurring during catecholamine metabolism. We therefore decided to assess the efficacy of a powerful free radical scavenging agent, alpha-tocopherol (vitamin E), on the clinical signs of TD. We treated 15 patients with persistent TD with alpha-tocopherol and matched placebo in a randomized crossover design. Patients demonstrated a significant overall reduction in scores on the Abnormal Involuntary Movements Scale (AIMS) after treatment with alpha-tocopherol, but not after placebo. The mean reduction in the AIMS score with alpha-tocopherol was 43 percent, with seven patients showing a greater than 50 percent reduction in their dyskinesia. There was also a trend for a decrease in scores on the Brief Psychiatric Rating Scale, but no change was observed in scores on the Simpson-Angus Scale for Extrapyramidal Side Effects. Our findings are consistent with the possibility that alpha-tocopherol is beneficial in the treatment of some patients with TD, but further research is necessary to establish the efficacy of this agent. JF - Schizophrenia bulletin AU - Lohr, J B AU - Cadet, J L AU - Lohr, M A AU - Larson, L AU - Wasli, E AU - Wade, L AU - Hylton, R AU - Vidoni, C AU - Jeste, D V AU - Wyatt, R J AD - Department of Psychiatry, San Diego Veterans Administration Medical Center, La Jolla, CA 92161. Y1 - 1988 PY - 1988 DA - 1988 SP - 291 EP - 296 VL - 14 IS - 2 SN - 0586-7614, 0586-7614 KW - Antipsychotic Agents KW - 0 KW - Free Radicals KW - Peroxides KW - Vitamin E KW - 1406-18-4 KW - perhydroxyl radical KW - 3170-83-0 KW - Index Medicus KW - Drug Administration Schedule KW - Psychiatric Status Rating Scales KW - Dyskinesia, Drug-Induced KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Schizophrenic Psychology KW - Peroxides -- metabolism KW - Brain -- drug effects KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Vitamin E -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78571899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+bulletin&rft.atitle=Vitamin+E+in+the+treatment+of+tardive+dyskinesia%3A+the+possible+involvement+of+free+radical+mechanisms.&rft.au=Lohr%2C+J+B%3BCadet%2C+J+L%3BLohr%2C+M+A%3BLarson%2C+L%3BWasli%2C+E%3BWade%2C+L%3BHylton%2C+R%3BVidoni%2C+C%3BJeste%2C+D+V%3BWyatt%2C+R+J&rft.aulast=Lohr&rft.aufirst=J&rft.date=1988-01-01&rft.volume=14&rft.issue=2&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+bulletin&rft.issn=05867614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-19 N1 - Date created - 1989-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship between in vitro and in vivo radiosensitivity of lymphocytes in chronic lymphocytic leukemia. AN - 78543801; 3143211 AB - A significant positive correlation was obtained between the in vitro radiosensitivity of the blood lymphocytes of patients with chronic lymphocytic leukemia (CLL) and the in vivo response of the total leukocyte count subsequent to radiation therapy. Four types of equations were used to represent and measure the effect of in vitro X-irradiation on lymphocytes from CLL patients and measure the response of patients to a course of radiotherapy. For the in vivo analysis we used data from 10 patients who were routinely treated with a total of 16 courses of radiation therapy. The total leukocyte count showed a uniform exponential decline during a course of therapy. According to the literature, about 25% of all CLL patients and about 50% of CLL patients with advanced disease are resistant to chemotherapy. The equations and indices of the present study may be useful to diagnose CLL patients who are prone to be resistant to chemotherapy. JF - Acta haematologica AU - Schrek, R AU - Best, W R AU - Stefani, S AD - Research Service, Veterans Administration Hospital, Hines, Ill. Y1 - 1988 PY - 1988 DA - 1988 SP - 129 EP - 133 VL - 80 IS - 3 SN - 0001-5792, 0001-5792 KW - Index Medicus KW - Leukocyte Count -- radiation effects KW - Humans KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Lymphocytes -- radiation effects KW - Leukemia, Lymphocytic, Chronic, B-Cell -- radiotherapy KW - Leukemia, Lymphocytic, Chronic, B-Cell -- pathology KW - Cell Survival -- radiation effects KW - Tumor Cells, Cultured -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78543801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+haematologica&rft.atitle=Relationship+between+in+vitro+and+in+vivo+radiosensitivity+of+lymphocytes+in+chronic+lymphocytic+leukemia.&rft.au=Schrek%2C+R%3BBest%2C+W+R%3BStefani%2C+S&rft.aulast=Schrek&rft.aufirst=R&rft.date=1988-01-01&rft.volume=80&rft.issue=3&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Acta+haematologica&rft.issn=00015792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-12 N1 - Date created - 1989-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of sexual maturity on testicular injury subsequent to procarbazine administration in rats. AN - 78533200; 3190359 AB - The present study examined the effect of age on various aspects of Leydig cell and Sertoli cell function in Sprague-Dawley rats administered procarbazine. Procarbazine was administered intraperitoneally to Sprague-Dawley rats aged 14, 24, and 60 days in 3 weekly injections of 200 mg/kg. Animals were sacrificed 1 week after the last injection. Severe impairment of spermatogenesis was evident in all animals. Sertoli cell function, as assessed by total testicular ABP content, was not significantly different between procarbazine-treated animals and controls in any age group. On the other hand, procarbazine administration resulted in a 60% reduction in total intratesticular testosterone content in the 14-day-old rats but not in the 24- or 60-day-old animals. Serum testosterone was significantly reduced by 50% in the group of 14-day-old animals but not in the other age groups. Serum LH values were not significantly changed from control levels in any age group. Testicular content of Fe, Zn, Mn, and Cn were unaltered by procarbazine administration in any age group. Since serum LH and testicular cation content were not affected by procarbazine treatment, the significant decreases in serum and testicular testosterone in 14-day-old animals after procarbazine administration may indicate a direct age-dependent effect of procarbazine on Leydig cell function. JF - Archives of andrology AU - Pogach, L M AU - Lee, Y AU - Giglio, W AU - Huang, H F AD - Department of Medicine, East Orange Veterans Administration Medical Center, New Jersey 07019. Y1 - 1988 PY - 1988 DA - 1988 SP - 37 EP - 43 VL - 21 IS - 1 SN - 0148-5016, 0148-5016 KW - Hormones KW - 0 KW - Metals KW - Procarbazine KW - 35S93Y190K KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Body Weight -- drug effects KW - Hormones -- metabolism KW - Spermatogenesis -- drug effects KW - Metals -- metabolism KW - Radioimmunoassay KW - Leydig Cells -- drug effects KW - Male KW - Organ Size -- drug effects KW - Testis -- metabolism KW - Testis -- drug effects KW - Procarbazine -- toxicity KW - Sexual Maturation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78533200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+andrology&rft.atitle=Effect+of+sexual+maturity+on+testicular+injury+subsequent+to+procarbazine+administration+in+rats.&rft.au=Pogach%2C+L+M%3BLee%2C+Y%3BGiglio%2C+W%3BHuang%2C+H+F&rft.aulast=Pogach&rft.aufirst=L&rft.date=1988-01-01&rft.volume=21&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Archives+of+andrology&rft.issn=01485016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-21 N1 - Date created - 1988-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bone lead and the diagnosis of lead nephropathy. AN - 78484584; 3141113 JF - Contributions to nephrology AU - Wedeen, R P AU - Van de Vyver, F L AU - D'Haese, P C AU - Visser, W J AU - Elseviers, M M AU - Knippenberg, L J AU - Lamberts, L V AU - De Broe, M E AU - Batuman, V AU - Schidlovsky, G AD - Veterans Administration Medical Center, East Orange, N.J. Y1 - 1988 PY - 1988 DA - 1988 SP - 102 EP - 108 VL - 64 SN - 0302-5144, 0302-5144 KW - Lead KW - 2P299V784P KW - Edetic Acid KW - 9G34HU7RV0 KW - Index Medicus KW - X-Rays KW - Fluorescence KW - Humans KW - Bone and Bones -- analysis KW - Lead Poisoning -- diagnosis KW - Lead -- analysis KW - Kidney Diseases -- diagnosis KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78484584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=Bone+lead+and+the+diagnosis+of+lead+nephropathy.&rft.au=Wedeen%2C+R+P%3BVan+de+Vyver%2C+F+L%3BD%27Haese%2C+P+C%3BVisser%2C+W+J%3BElseviers%2C+M+M%3BKnippenberg%2C+L+J%3BLamberts%2C+L+V%3BDe+Broe%2C+M+E%3BBatuman%2C+V%3BSchidlovsky%2C+G&rft.aulast=Wedeen&rft.aufirst=R&rft.date=1988-01-01&rft.volume=64&rft.issue=&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-12 N1 - Date created - 1988-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anterior pituitary involvement in Wegener's granulomatosis. AN - 78467524; 3172100 AB - Wegener's granulomatosis rarely involves the pituitary, and is limited to the posterior gland. A young woman developed sinusitis, otitis media, asymptomatic pulmonary density, blindness, and anterior pituitary hormone deficiency over 7 years. Mucosal biopsies showed only chronic necrotizing inflammation without vasculitis. Since her clinical course suggested an atypical presentation of Wegener's granulomatosis, cyclophosphamide was finally added to corticosteroid therapy. All symptoms but monocular blindness and hypopituitarism remitted. JF - The Journal of rheumatology AU - Lohr, K M AU - Ryan, L M AU - Toohill, R J AU - Anderson, T AD - Department of Medicine, Veterans Administration Medical Center, Milwaukee, WI. Y1 - 1988 PY - 1988 DA - 1988 SP - 855 EP - 857 VL - 15 IS - 5 SN - 0315-162X, 0315-162X KW - Adrenal Cortex Hormones KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Adrenal Cortex Hormones -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Humans KW - Hypopituitarism -- etiology KW - Adult KW - Biopsy KW - Respiratory System -- pathology KW - Female KW - Blindness -- etiology KW - Pituitary Gland -- pathology KW - Granulomatosis with Polyangiitis -- pathology KW - Granulomatosis with Polyangiitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78467524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Anterior+pituitary+involvement+in+Wegener%27s+granulomatosis.&rft.au=Lohr%2C+K+M%3BRyan%2C+L+M%3BToohill%2C+R+J%3BAnderson%2C+T&rft.aulast=Lohr&rft.aufirst=K&rft.date=1988-01-01&rft.volume=15&rft.issue=5&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arachidonic acid metabolism by human urothelial cells: implication in aromatic amine-induced bladder cancer. AN - 78431147; 3138699 JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Zenser, T V AU - Davis, B B AD - Geriatric Research Education and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125. Y1 - 1988 PY - 1988 DA - 1988 SP - 199 EP - 207 VL - 31 IS - 3 SN - 0952-3278, 0952-3278 KW - Amines KW - 0 KW - Arachidonic Acids KW - Carcinogens KW - Arachidonic Acid KW - 27YG812J1I KW - Index Medicus KW - Animals KW - Humans KW - Epithelium -- metabolism KW - Urinary Bladder -- metabolism KW - Arachidonic Acids -- metabolism KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78431147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Arachidonic+acid+metabolism+by+human+urothelial+cells%3A+implication+in+aromatic+amine-induced+bladder+cancer.&rft.au=Zenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Zenser&rft.aufirst=T&rft.date=1988-01-01&rft.volume=31&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-25 N1 - Date created - 1988-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Memory effect of DL-threo-3,4-dihydroxyphenylserine (DOPS) in human Korsakoff's disease. AN - 78395234; 3137605 AB - A group of amnesic patients with Korsakoff's disease were treated with a single 1 g dose of DL-threo-3,4-dihydroxyphenylserine (DOPS) and placebo (lactose) in a double-blind crossover study. Three hours following administration, patients were given a battery of psychometric tests to determine the effects of the treatment on memory functions. Administration of DOPS had a significant effect on performance on the Memory Passages test but not on any of the other measures of memory. The effect of DOPS on Memory Passages is similar to the response observed following administration of clonidine in Korsakoff patients. Blood pressure and pulse, measured before and every 2 h after treatment, were unaffected by DOPS. JF - Psychopharmacology AU - Langlais, P J AU - Mair, R G AU - Whalen, P J AU - McCourt, W AU - McEntee, W J AD - Research Service, Veterans Administration Medical Center, Brockton, MA 02401. Y1 - 1988 PY - 1988 DA - 1988 SP - 250 EP - 254 VL - 95 IS - 2 SN - 0033-3158, 0033-3158 KW - Serine KW - 452VLY9402 KW - Droxidopa KW - J7A92W69L7 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Humans KW - Middle Aged KW - Psychometrics KW - Male KW - Serine -- analogs & derivatives KW - Alcohol Amnestic Disorder -- complications KW - Alcohol Amnestic Disorder -- physiopathology KW - Memory Disorders -- etiology KW - Memory Disorders -- drug therapy KW - Droxidopa -- therapeutic use KW - Droxidopa -- adverse effects KW - Alcohol Amnestic Disorder -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78395234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Memory+effect+of+DL-threo-3%2C4-dihydroxyphenylserine+%28DOPS%29+in+human+Korsakoff%27s+disease.&rft.au=Langlais%2C+P+J%3BMair%2C+R+G%3BWhalen%2C+P+J%3BMcCourt%2C+W%3BMcEntee%2C+W+J&rft.aulast=Langlais&rft.aufirst=P&rft.date=1988-01-01&rft.volume=95&rft.issue=2&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-04 N1 - Date created - 1988-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biphasic control of polymorphonuclear cell migration by Kupffer cells. Effect of exposure to metabolic products of ethanol. AN - 78353327; 2840542 AB - In order to investigate the role of the Kupffer cells in the regulation of the inflammatory reaction seen in alcoholic hepatitis, rat liver Kupffer cells were cultured and exposed to products of ethanol metabolism. The resultant supernatants were tested to study their ability to stimulate or inhibit polymorphonuclear cell chemotaxis. Kupffer cells produced increased chemokinetic activity for human polymorphonuclear leukocytes (84 +/- 6 vs. 61 +/- 4 randomly migrating cells per 5 high power fields; p less than 0.01); when incubated with soluble products of microsomal peroxidation, the Kupffer cells engendered more chemokinetic activity than that produced by untreated Kupffer cells (106 +/- 6 vs. 84 +/- 6 cells per 5 high power fields; p less than 0.05). When Kupffer cells were incubated with acetaldehyde, the chemokinetic activity that appeared in the supernatant did not differ from control (51 +/- 3 vs. 61 +/- 4 randomly migrating cells per 5 high power fields; p = NS). Chemotaxis of polymorphonuclear cells was not observed when the Kupffer cell supernatants were tested by checkerboard analysis. Kupffer cells released a factor which, at different concentrations, inhibited the response of polymorphonuclear cells to the synthetic polypeptide chemotactic factor f-met-leu-phe by 47% (p less than 0.001). This effect was unchanged when the cells were exposed to acetaldehyde or to soluble products of microsomal peroxidation. Our results demonstrate that Kupffer cells are capable of stimulating or inhibiting polymorphonuclear cell chemotaxis and that some of these effects may be influenced by the products of ethanol metabolism, suggesting that Kupffer cells may play an important role in the regulation of the inflammatory reaction seen in alcoholic hepatitis. JF - Life sciences AU - Fainsilber, Z AU - Feinman, L AU - Shaw, S AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bx, NY 10468. Y1 - 1988 PY - 1988 DA - 1988 SP - 603 EP - 608 VL - 43 IS - 7 SN - 0024-3205, 0024-3205 KW - Ethanol KW - 3K9958V90M KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Peroxidase KW - EC 1.11.1.7 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Animals KW - Acetaldehyde -- pharmacology KW - Microsomes, Liver -- metabolism KW - Peroxidase -- metabolism KW - Hepatitis, Alcoholic -- metabolism KW - Chemotaxis, Leukocyte -- drug effects KW - Ethanol -- pharmacology KW - Kupffer Cells -- physiology KW - Neutrophils -- physiology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Biphasic+control+of+polymorphonuclear+cell+migration+by+Kupffer+cells.+Effect+of+exposure+to+metabolic+products+of+ethanol.&rft.au=Fainsilber%2C+Z%3BFeinman%2C+L%3BShaw%2C+S%3BLieber%2C+C+S&rft.aulast=Fainsilber&rft.aufirst=Z&rft.date=1988-01-01&rft.volume=43&rft.issue=7&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevalence of childhood physical abuse in adult male veteran alcoholics. AN - 78326332; 3260808 AB - Although past research has identified psychological and behavioral consequences for adults who were abused as children, few studies have examined the incidence and consequences of childhood physical abuse among adult alcoholics. The purpose of this study was to assess the prevalence of a childhood history of physical abuse in adult male alcoholics and to determine what differences may exist in the psychological profile and patterns of alcohol abuse in abused and nonabused alcoholics. The study sample was comprised of 100 male alcoholic inpatients from the alcoholism treatment unit at a metropolitan Veterans Administration hospital. Subjects were administered a self-report devised by the authors to assess a history of childhood physical abuse, the Michigan Alcoholism Screening Test (MAST), the Severity of Alcohol Dependence Questionnaire (SADQ), and the Symptom Checklist-90-Revised (SCL-90-R). Findings indicated that approximately one-third of the alcoholics were physically abused as children. Abused alcoholics reported having more severe psychological symptoms and distress than their nonabused counterparts, although they did not differ on the onset, severity, or treatment history for alcohol dependency. JF - Child abuse & neglect AU - Schaefer, M R AU - Sobieraj, K AU - Hollyfield, R L AD - Veterans Administration Edward Hines Jr. Hospital, Hines, IL 60141. Y1 - 1988 PY - 1988 DA - 1988 SP - 141 EP - 149 VL - 12 IS - 2 SN - 0145-2134, 0145-2134 KW - Index Medicus KW - Cross-Sectional Studies KW - Risk Factors KW - Humans KW - Battered Child Syndrome KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Psychometrics KW - Male KW - Psychological Tests KW - Child Abuse -- psychology KW - Veterans -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78326332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+abuse+%26+neglect&rft.atitle=Prevalence+of+childhood+physical+abuse+in+adult+male+veteran+alcoholics.&rft.au=Schaefer%2C+M+R%3BSobieraj%2C+K%3BHollyfield%2C+R+L&rft.aulast=Schaefer&rft.aufirst=M&rft.date=1988-01-01&rft.volume=12&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Child+abuse+%26+neglect&rft.issn=01452134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-01 N1 - Date created - 1988-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bronchial pathology in chronic marijuana smokers: a light and electron microscopic study. AN - 78320131; 3392631 JF - Journal of psychoactive drugs AU - Fligiel, S E AU - Venkat, H AU - Gong, H AU - Tashkin, D P AD - Department of Pathology, Veterans Administration Medical Center-Wayne State University, Detroit, Michigan. PY - 1988 SP - 33 EP - 42 VL - 20 IS - 1 SN - 0279-1072, 0279-1072 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Bronchoscopy KW - Precancerous Conditions -- chemically induced KW - Humans KW - Adult KW - Middle Aged KW - Microscopy, Electron KW - Smoking -- pathology KW - Cocaine -- adverse effects KW - Bronchial Neoplasms -- chemically induced KW - Microscopy, Electron, Scanning KW - Marijuana Smoking -- pathology KW - Bronchi -- ultrastructure KW - Bronchi -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78320131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Bronchial+pathology+in+chronic+marijuana+smokers%3A+a+light+and+electron+microscopic+study.&rft.au=Fligiel%2C+S+E%3BVenkat%2C+H%3BGong%2C+H%3BTashkin%2C+D+P&rft.aulast=Fligiel&rft.aufirst=S&rft.date=1988-01-01&rft.volume=20&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-17 N1 - Date created - 1988-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations in synaptic membrane molecular order associated with alcoholization and protein deficiency in rats. AN - 78293866; 3133699 AB - The effects of chronic alcoholization and protein deficiency on synaptic membrane characteristics were studied in rats fed the following four liquid diets for 4 weeks: a protein-deficient diet containing alcohol, a protein-deficient diet containing no alcohol, a non-protein-deficient diet containing alcohol and a non-protein-deficient diet containing no alcohol. A fluorescent probe, diphenylhexatriene (DPH), was used to estimate the fluidity of synaptic membranes and their sensitivity to the fluidizing effect of ethanol added in vitro, in concentrations ranging from 50 mM to 800 mM. Prior to in vitro addition of ethanol, the difference between the fluidity of synaptic membranes of alcoholized and non-alcoholized animals was significant for the two groups of protein-deficient animals but not for the two groups of non-protein-deficient animals. After in vitro addition of ethanol, the differences between the fluidity of synaptic membranes of the alcoholized and non-alcoholized animals were larger and more frequently significant for the protein-deficient animals than for the non-protein-deficient animals. In view of previous observations that rats fed a protein-deficient diet experience more severe withdrawal symptoms following alcoholization than rats fed a nutritionally adequate diet, the results of the present experiment lend additional support to the hypothesis that tolerance and dependence may be mediated by alterations in biomembrane characteristics. JF - Psychopharmacology AU - Branchey, M H AU - Buydens-Branchey, L AU - Korsten, M A AU - Richman, E I AU - Wilson, J S AU - Lieber, C S AD - Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1988 PY - 1988 DA - 1988 SP - 43 EP - 48 VL - 95 IS - 1 SN - 0033-3158, 0033-3158 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Molecular Conformation KW - Male KW - Protein Deficiency -- metabolism KW - Alcoholism -- metabolism KW - Synaptic Membranes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78293866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Alterations+in+synaptic+membrane+molecular+order+associated+with+alcoholization+and+protein+deficiency+in+rats.&rft.au=Branchey%2C+M+H%3BBuydens-Branchey%2C+L%3BKorsten%2C+M+A%3BRichman%2C+E+I%3BWilson%2C+J+S%3BLieber%2C+C+S&rft.aulast=Branchey&rft.aufirst=M&rft.date=1988-01-01&rft.volume=95&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-10 N1 - Date created - 1988-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Two-drug combinations of memory enhancers: effect of dose ratio upon potency and therapeutic window, in mice. AN - 78291957; 3386399 AB - Two-drug combinations have been reported to enhance retention more effectively than when either drug was administered alone at the same dose. Some combinations of cholinergic drugs enhance retention even though the total drug dosage is reduced by as much as 97% compared to the dose needed to improve retention when the same drugs are administered singly. The choice of dose ratio is usually arbitrary or based on empirical results. The present study systematically varied the ratio of two drugs in a combination and at the same time varied the dosage of each drug. The drug combinations were administered to mice immediately after training on T-maze footshock avoidance task. Retention was tested one week later. Three two-drug combinations were selected for presentation because they differed considerably as to (a) the lowest effective total dose that improved memory-retention, (b) the optimal ratio that improved retention and (c) the width of the therapeutic window. The effect of a drug combination on retention was found to be dependent on the particular drugs in the combination, the ratio and the dose administered. JF - Life sciences AU - Flood, J F AU - Smith, G E AU - Cherkin, A AD - Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Medical Center, Sepulveda, CA 91343. Y1 - 1988 PY - 1988 DA - 1988 SP - 2145 EP - 2154 VL - 42 IS - 21 SN - 0024-3205, 0024-3205 KW - Drug Combinations KW - 0 KW - Parasympathomimetics KW - Arecoline KW - 4ALN5933BH KW - Tacrine KW - 4VX7YNB537 KW - Oxotremorine KW - 5RY0UWH1JL KW - Edrophonium KW - 70FP3JLY7N KW - Index Medicus KW - Animals KW - Drug Interactions KW - Oxotremorine -- administration & dosage KW - Edrophonium -- administration & dosage KW - Mice KW - Arecoline -- administration & dosage KW - Tacrine -- administration & dosage KW - Male KW - Memory -- drug effects KW - Parasympathomimetics -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78291957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Two-drug+combinations+of+memory+enhancers%3A+effect+of+dose+ratio+upon+potency+and+therapeutic+window%2C+in+mice.&rft.au=Flood%2C+J+F%3BSmith%2C+G+E%3BCherkin%2C+A&rft.aulast=Flood&rft.aufirst=J&rft.date=1988-01-01&rft.volume=42&rft.issue=21&rft.spage=2145&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-29 N1 - Date created - 1988-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of accelerated wound repair using epidermal growth factor and basic fibroblast growth factor. AN - 78263503; 3289048 JF - Progress in clinical and biological research AU - Davidson, J AU - Buckley, A AU - Woodward, S AU - Nichols, W AU - McGee, G AU - Demetriou, A AD - Veterans Administration Medical Center, Nashville, Tennessee. Y1 - 1988 PY - 1988 DA - 1988 SP - 63 EP - 75 VL - 266 SN - 0361-7742, 0361-7742 KW - Phorbol Esters KW - 0 KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Stimulation, Chemical KW - Rats KW - Granulation Tissue -- pathology KW - Granulation Tissue -- metabolism KW - Phorbol Esters -- pharmacology KW - Animals KW - Cattle KW - Foreign-Body Reaction KW - Cells, Cultured KW - Collagen -- biosynthesis KW - Models, Biological KW - Wound Healing -- drug effects KW - Epidermal Growth Factor -- pharmacology KW - Fibroblast Growth Factors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78263503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Mechanisms+of+accelerated+wound+repair+using+epidermal+growth+factor+and+basic+fibroblast+growth+factor.&rft.au=Davidson%2C+J%3BBuckley%2C+A%3BWoodward%2C+S%3BNichols%2C+W%3BMcGee%2C+G%3BDemetriou%2C+A&rft.aulast=Davidson&rft.aufirst=J&rft.date=1988-01-01&rft.volume=266&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-18 N1 - Date created - 1988-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transmission electron microscopy of urinary sediment in the assessment of aminoglycoside nephrotoxicity in the rat. AN - 78263165; 3380221 AB - Transmission electron microscopy was used to study urine sediment and renal tissue from Fischer rats treated with gentamicin or tobramycin 40 mg/kg/day or sterile water (control) subcutaneously for 5 or 10 days. Renal function was assessed by serum urea nitrogen and 24-hour creatinine clearance. Urine sediment was examined for myeloid bodies and renal tubule cells. After 5 days, the renal function was not different, but myeloid bodies, renal tubule cells, and abnormal renal morphology were found only in tobramycin-treated animals. After 10 days, serum urea nitrogen was higher (p less than 0.05) and creatinine clearance lower (p less than 0.01) in treated than control animals. Myeloid bodies and renal tubule cells were found uniformly in treated animals. Transmission electron microscopy kidneys revealed abnormalities in treated animals, but focal tubular necrosis was found only in gentamicin-treated animals. This study using urinary sediment transmission electron microscopy as a sensitive technique reveals that tobramycin produces earlier but less severe aminoglycoside nephrotoxicity than gentamicin. Renal pathological changes may occur despite the absence of major decreases in renal function. JF - Nephron AU - Mandal, A K AU - Bennett, W M AD - Department of Medicine, Veterans Administration Medical Center, Dayton, Ohio. Y1 - 1988 PY - 1988 DA - 1988 SP - 67 EP - 73 VL - 49 IS - 1 SN - 1660-8151, 1660-8151 KW - Aminoglycosides KW - 0 KW - Gentamicins KW - Creatinine KW - AYI8EX34EU KW - Tobramycin KW - VZ8RRZ51VK KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Kidney Cortex -- analysis KW - Injections, Subcutaneous KW - Microscopy, Electron KW - Blood Urea Nitrogen KW - Aminoglycosides -- toxicity KW - Creatinine -- blood KW - Male KW - Aminoglycosides -- analysis KW - Tobramycin -- analysis KW - Gentamicins -- analysis KW - Gentamicins -- toxicity KW - Urine -- cytology KW - Kidney -- pathology KW - Kidney -- drug effects KW - Tobramycin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78263165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Transmission+electron+microscopy+of+urinary+sediment+in+the+assessment+of+aminoglycoside+nephrotoxicity+in+the+rat.&rft.au=Mandal%2C+A+K%3BBennett%2C+W+M&rft.aulast=Mandal&rft.aufirst=A&rft.date=1988-01-01&rft.volume=49&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-15 N1 - Date created - 1988-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin in rabbits. AN - 78225160; 3370741 AB - The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin was studied in six female New Zealand white rabbits. Plasma pharmacokinetic data were first obtained from rabbits given 3 mg/kg doxorubicin. After 1 month, the same rabbits were treated with ranitidine, 2.5 mg/kg or 25 mg/kg, before and during doxorubicin administration. The plasma doxorubicin assays to determine pharmacokinetic parameters were repeated. Drug toxicity was evaluated using complete blood counts, and hepatic function was measured using a 14C-aminopyrine breath test. High-dose ranitidine increased the total exposure to doxorubicin (area under the curve of doxorubicin alone = 1.44 +/- 0.88 microM.h/ml vs 4.49 +/- 2.35 microM.hr/ml for doxorubicin given with high-dose ranitidine; P = 0.06). Low-dose ranitidine did not alter doxorubicin pharmacokinetics. Exposure to doxorubicinol was altered by either high-dose or low-dose ranitidine. 14C-Aminopyrine half-life was altered by a ranitidine dose of 25 mg/kg (aminopyrine half-life after placebo control = 97 +/- 6 min as against aminopyrine half-life after ranitidine = 121 +/- 7 min; mean +/- SEM; P less than 0.02). Low-dose ranitidine did not exacerbate doxorubicin-induced myelosuppression. High-dose ranitidine enhanced doxorubicin-induced erythroid suppression while sparing the myeloid series. At cytochrome P-450-inhibitory doses, ranitidine's effects upon doxorubicin plasma pharmacokinetics are similar to those previously seen with cimetidine. These changes did not appear to alter drug detoxification and are not related to microsomal inhibition of doxorubicin detoxification. Low doses of ranitidine do not alter doxorubicin plasma pharmacokinetics or toxicity in rabbits. JF - Cancer chemotherapy and pharmacology AU - Harris, N L AU - Brenner, D E AU - Anthony, L B AU - Collins, J C AU - Halter, S AU - Hande, K R AD - Department of Medicine, Nashville Veterans Administration Medical Center, TN 37203. Y1 - 1988 PY - 1988 DA - 1988 SP - 323 EP - 328 VL - 21 IS - 4 SN - 0344-5704, 0344-5704 KW - Aminopyrine KW - 01704YP3MO KW - Cimetidine KW - 80061L1WGD KW - Doxorubicin KW - 80168379AG KW - Ranitidine KW - 884KT10YB7 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Aminopyrine -- analysis KW - Dose-Response Relationship, Drug KW - Metabolic Clearance Rate KW - Rabbits KW - Cimetidine -- pharmacology KW - Female KW - Breath Tests KW - Ranitidine -- pharmacology KW - Doxorubicin -- pharmacokinetics KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Doxorubicin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78225160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=The+influence+of+ranitidine+on+the+pharmacokinetics+and+toxicity+of+doxorubicin+in+rabbits.&rft.au=Harris%2C+N+L%3BBrenner%2C+D+E%3BAnthony%2C+L+B%3BCollins%2C+J+C%3BHalter%2C+S%3BHande%2C+K+R&rft.aulast=Harris&rft.aufirst=N&rft.date=1988-01-01&rft.volume=21&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-05 N1 - Date created - 1988-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of drug-induced pulmonary disease. AN - 78224866; 2453156 AB - Administration of a number of therapeutic agents is associated with respiratory alterations. Mechanisms of these alterations are unclear but may include both direct toxic effects of the drugs and indirect effects through actions of the drugs on inflammatory cells. This review discusses mechanisms of the varied patterns of drug-induced pulmonary disease. JF - Annual review of medicine AU - Cooper, J A AU - Zitnik, R J AU - Matthay, R A AD - Pulmonary Division, West Haven Veterans Administration Medical Center 06516. Y1 - 1988 PY - 1988 DA - 1988 SP - 395 EP - 404 VL - 39 SN - 0066-4219, 0066-4219 KW - Bleomycin KW - 11056-06-7 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Alveolitis, Extrinsic Allergic -- chemically induced KW - Pulmonary Fibrosis -- chemically induced KW - Humans KW - Pulmonary Edema -- chemically induced KW - Bronchial Spasm -- chemically induced KW - Lung Diseases -- chemically induced KW - Amiodarone -- adverse effects KW - Bleomycin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78224866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+medicine&rft.atitle=Mechanisms+of+drug-induced+pulmonary+disease.&rft.au=Cooper%2C+J+A%3BZitnik%2C+R+J%3BMatthay%2C+R+A&rft.aulast=Cooper&rft.aufirst=J&rft.date=1988-01-01&rft.volume=39&rft.issue=&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+medicine&rft.issn=00664219&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-13 N1 - Date created - 1988-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tobacco smoking: a comparison between alcohol and drug abuse inpatients. AN - 78222396; 3369328 AB - This study compared the tobacco smoking of alcohol and drug abuse patients. The subjects were male inpatients (67 alcohol, 60 drug, and 13 mixed alcohol and drug abusers) of a Veterans Administration substance abuse program who had completed the Tolerance Questionnaire (Fagerstrom, 1978) and the Michigan Alcohol Screening Test (Skinner, 1979) as part of routine intake assessment procedures. As expected, an extremely high percentage (89.6%) of the alcohol abusers reported smoking cigarettes. Interestingly, an equally high prevalence of smoking was noted among the drug (90.0%) and mixed substance abuse (100%) groups. Comparisons conducted between abuse groups indicated that the alcohol abusers smoked significantly more cigarettes per day and had significantly higher Tolerance Questionnaire scores than the drug abusers, but did not differ from the mixed abuse group on any smoking variable. Additional comparisons of the total substance abuse population with a national sample of similarly aged males indicated that only the alcohol group smoked more cigarettes per day, but that all substance abuse groups smoked higher nicotine delivery cigarettes than the national sample. JF - Addictive behaviors AU - Burling, T A AU - Ziff, D C AD - Palo Alto Veterans Administration Medical Center, San Jose State University. Y1 - 1988 PY - 1988 DA - 1988 SP - 185 EP - 190 VL - 13 IS - 2 SN - 0306-4603, 0306-4603 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Smoking KW - Drug Tolerance KW - Humans KW - Adult KW - Nicotine -- administration & dosage KW - Male KW - Substance-Related Disorders -- complications KW - Tobacco Use Disorder -- complications KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78222396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Tobacco+smoking%3A+a+comparison+between+alcohol+and+drug+abuse+inpatients.&rft.au=Burling%2C+T+A%3BZiff%2C+D+C&rft.aulast=Burling&rft.aufirst=T&rft.date=1988-01-01&rft.volume=13&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-16 N1 - Date created - 1988-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholics' attributions of factors affecting their relapse to drinking and reasons for terminating relapse episodes. AN - 78201631; 3364227 AB - This study was designed to examine alcoholics' attributions about their relapses. The subjects were 36 male alcoholic participants in a study of the effectiveness of group behavioral marital therapy (BMT) for alcoholism. Subjects' treatment condition had been determined by random assignment to either the BMT, interactional marital therapy, or control group. At a two year posttreatment follow-up interview, subjects were asked what they thought the main reasons were for starting and stopping drinking in their two most recent relapses. Subjects' responses showed that both interpersonal and psychological factors were perceived to affect relapses, with some treatment group differences in how relapses were viewed. Subjects reported a variety of factors in their stopping drinking, with anticipation of negative consequences the most frequently reported reason. The treatment groups did not differ on their attributions for relapse termination. The results were interpreted as replicating and extending previous studies of relapse among alcoholics by showing the importance of spouse and other family members in subjects' attributions of relapse and their termination. JF - Addictive behaviors AU - Maisto, S A AU - O'Farrell, T J AU - Connors, G J AU - McKay, J R AU - Pelcovits, M AD - Veterans Administration Medical Center Brockton, Massachusetts. Y1 - 1988 PY - 1988 DA - 1988 SP - 79 EP - 82 VL - 13 IS - 1 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Marital Therapy KW - Behavior Therapy KW - Risk Factors KW - Humans KW - Adult KW - Communication KW - Follow-Up Studies KW - Social Environment KW - Alcoholism -- rehabilitation KW - Set (Psychology) KW - Alcohol Drinking -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78201631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Alcoholics%27+attributions+of+factors+affecting+their+relapse+to+drinking+and+reasons+for+terminating+relapse+episodes.&rft.au=Maisto%2C+S+A%3BO%27Farrell%2C+T+J%3BConnors%2C+G+J%3BMcKay%2C+J+R%3BPelcovits%2C+M&rft.aulast=Maisto&rft.aufirst=S&rft.date=1988-01-01&rft.volume=13&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-31 N1 - Date created - 1988-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Memory in chronic alcoholics: effects of inconsistent versus consistent information. AN - 78197746; 3364219 AB - Alcoholics and controls were compared on their resistance to misleading information given after a witnessed event. The eyewitness testimony paradigm of Loftus, Miller, and Burns ("Semantic Integration of Verbal Information in a Visual Memory" Journal of Experimental Psychology: Human Learning and Memory, Vol. 4, pp. 19-31, 1978) was used, which is a naturalistic variation of a retroactive interference paradigm. Alcoholics did not show greater suggestibility than the controls, being no more "fooled" by the misleading, after-the-fact information. In contrast, alcoholics did show significant impairment in discriminating correct from among incorrect verbal statements about the accident. Thus, certain aspects of memory functioning may be preserved even while others are compromised as a result of chronic alcohol abuse. JF - Addictive behaviors AU - Ober, B A AU - Stillman, R C AD - Veterans Administration Medical Center, Livermore, CA 94550. Y1 - 1988 PY - 1988 DA - 1988 SP - 11 EP - 15 VL - 13 IS - 1 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Pattern Recognition, Visual -- drug effects KW - Discrimination Learning -- drug effects KW - Humans KW - Middle Aged KW - Male KW - Alcoholism -- rehabilitation KW - Alcohol Amnestic Disorder -- rehabilitation KW - Memory -- drug effects KW - Alcohol Amnestic Disorder -- psychology KW - Mental Recall -- drug effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78197746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Memory+in+chronic+alcoholics%3A+effects+of+inconsistent+versus+consistent+information.&rft.au=Ober%2C+B+A%3BStillman%2C+R+C&rft.aulast=Ober&rft.aufirst=B&rft.date=1988-01-01&rft.volume=13&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-31 N1 - Date created - 1988-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Coping and defending styles among Vietnam combat veterans seeking treatment for posttraumatic stress disorder and substance use disorder. AN - 78195365; 3363185 AB - A review of the literature on coping processes in addiction disorders yields at least two notions: one, that substance abuse is associated with less efficient, avoidant ways of coping with problems in living; and two, that substance abusers with a background of traumatic and stressful experiences are readily distinguishable by even more avoidant coping styles. These notions were tested in the form of three hypotheses: (1) substance abusers in general employ more avoidant coping styles than do nonaddicted groups; (2) Vietnam combat veterans meeting DSM-III criteria for both substance use disorder and posttraumatic stress disorder (PTSD) evidence significantly more avoidant coping styles than do Vietnam combat veterans meeting criteria only for substance use disorder but not PTSD--particularly when dealing with internal states of anxiety; and (3) for those meeting both substance use disorder and PTSD criteria, black Vietnam combat veterans (who presumably have encountered more stress, as minority group members) evidence more avoidant coping styles than do white Vietnam combat veterans. These three hypotheses were tested with Peck's (1981) newly developed Individual Styles of Coping, measuring four stages in the coping process for five behavioral contexts. All three hypotheses were confirmed. Results were discussed as confirming recent changes in DSM-III-Revised (1987) criteria, emphasizing generalized avoidance manuevers as criterial, in part, for diagnosing PTSD (in addition to behaviors of specific avoidance of traumatic memories). Theoretical implications about a traumatogenic dimension for substance abuse among some Vietnam combat veterans were discussed, as well as ramifications for treatment programming. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Penk, W E AU - Peck, R F AU - Robinowitz, R AU - Bell, W AU - Little, D AD - Psychology Service, Veterans Administration Medical Center, Boston, Massachusetts. Y1 - 1988 PY - 1988 DA - 1988 SP - 69 EP - 88 VL - 6 SN - 0738-422X, 0738-422X KW - Index Medicus KW - Humans KW - Adult KW - Heroin Dependence -- psychology KW - Male KW - Vietnam KW - Psychological Tests KW - Combat Disorders -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology KW - Combat Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Defense Mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78195365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Coping+and+defending+styles+among+Vietnam+combat+veterans+seeking+treatment+for+posttraumatic+stress+disorder+and+substance+use+disorder.&rft.au=Penk%2C+W+E%3BPeck%2C+R+F%3BRobinowitz%2C+R%3BBell%2C+W%3BLittle%2C+D&rft.aulast=Penk&rft.aufirst=W&rft.date=1988-01-01&rft.volume=6&rft.issue=&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Physiological and psychological factors as predictors of alcoholism risk. AN - 78194651; 3283860 AB - This chapter synthesizes data accruing since January 1984 from studies of populations at elevated risk for the future development of alcoholism. These recent data demonstrate the continued potential importance of the decreased intensity of reaction to ethanol in sons of alcoholics, a conclusion bolstered by replications of the less intense postethanol subjective ratings by the higher-risk group, as well as their demonstration of less intense changes in several hormones following drinking. Additional studies also indicate a possible importance of neuropsychological test deficits in higher-risk boys studied in their preteen or early-teen years; information continues to support the importance of the aldehyde dehydrogenase isoenzyme pattern for the alcoholism risk among Orientals, but little consistent information has yet identified other enzyme activity levels or personality profiles as factors significantly different for higher-risk and lower-risk populations. Although studies of populations at high risk for the future development of alcoholism are relatively new, the findings to date have been interesting and could lead to important future developments in prevention and treatment of this prevalent disorder. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Schuckit, M A AD - Alcohol Research Center, San Diego Veterans Administration Medical Center, California. Y1 - 1988 PY - 1988 DA - 1988 SP - 311 EP - 322 VL - 6 SN - 0738-422X, 0738-422X KW - Index Medicus KW - Psychomotor Performance -- drug effects KW - Risk Factors KW - Humans KW - Neuropsychological Tests KW - Alcohol Drinking -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78194651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Physiological+and+psychological+factors+as+predictors+of+alcoholism+risk.&rft.au=Schuckit%2C+M+A&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1988-01-01&rft.volume=6&rft.issue=&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The interrelationship of substance abuse and posttraumatic stress disorder. Epidemiological and clinical considerations. AN - 78194600; 3283857 AB - This chapter reviews the data available on the relationship of substance abuse and posttraumatic stress disorder (PTSD). Delimiting the review to those studies of Vietnam veterans, we found that levels of combat exposure seemed to be positively related to subsequent alcohol use, although not all studies confirmed this relationship. When studies of patients seeking treatment for PTSD were examined, we learned that 60-80% of these patients had concurrent diagnoses of substance abuse, alcohol abuse, or dependence. Methodological limitations of all the studies are discussed and conclusions regarding the status of the PTSD-substance abuse relationship are drawn cautiously. Alternative suggestions for treatment are presented and discussed. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Keane, T M AU - Gerardi, R J AU - Lyons, J A AU - Wolfe, J AD - Psychology Service, Boston Veterans Administration Medical Center, Massachusetts 02130. Y1 - 1988 PY - 1988 DA - 1988 SP - 27 EP - 48 VL - 6 SN - 0738-422X, 0738-422X KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Male KW - Vietnam KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Combat Disorders -- psychology KW - Alcoholism -- epidemiology KW - Veterans -- psychology KW - Combat Disorders -- epidemiology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78194600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=The+interrelationship+of+substance+abuse+and+posttraumatic+stress+disorder.+Epidemiological+and+clinical+considerations.&rft.au=Keane%2C+T+M%3BGerardi%2C+R+J%3BLyons%2C+J+A%3BWolfe%2C+J&rft.aulast=Keane&rft.aufirst=T&rft.date=1988-01-01&rft.volume=6&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Considerations for survival in program evaluation projects. AN - 78181327; 3360532 AB - Program evaluation research is presented as an increasingly necessary and valuable activity. Some "rules" are presented as a vehicle for the delineation of areas of concern that speak to the practical side of conducting this type of research. JF - The International journal of the addictions AU - Alfano, A M AU - Nerviano, V J AD - Veterans Administration Medical Center, St. Cloud, Minnesota 56301. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 109 EP - 113 VL - 23 IS - 1 SN - 0020-773X, 0020-773X KW - Index Medicus KW - United States KW - Patient Care Team -- standards KW - Humans KW - Substance-Related Disorders -- rehabilitation KW - Community Mental Health Services -- standards KW - Outcome and Process Assessment (Health Care) -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78181327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Considerations+for+survival+in+program+evaluation+projects.&rft.au=Alfano%2C+A+M%3BNerviano%2C+V+J&rft.aulast=Alfano&rft.aufirst=A&rft.date=1988-01-01&rft.volume=23&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The dipsas revisited: comments on addiction and personality. AN - 78180692; 2452257 JF - Journal of substance abuse treatment AU - Rinsley, D B AD - Colmery-O'Neil Veterans Administration Medical Center, Topeka, Kansas 66622. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 7 VL - 5 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Mother-Child Relations KW - Humans KW - Developmental Disabilities -- psychology KW - Personality Development KW - Developmental Disabilities -- complications KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- etiology KW - Borderline Personality Disorder -- psychology KW - Psychoanalytic Therapy KW - Personality Disorders -- psychology KW - Borderline Personality Disorder -- etiology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78180692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=The+dipsas+revisited%3A+comments+on+addiction+and+personality.&rft.au=Rinsley%2C+D+B&rft.aulast=Rinsley&rft.aufirst=D&rft.date=1988-01-01&rft.volume=5&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-31 N1 - Date created - 1988-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test. AN - 78174847; 3128805 AB - The central nervous system stimulants corticotropin releasing factor (CRF) and amphetamine were administered in combination with the benzodiazepine ligands Ro 15-1788 and FG 7142 in order to assess their benzodiazepine agonist and antagonist receptor properties in an operant conflict test in rats. Ro 15-1788, which was without behavioral activity in this test when given alone, reversed the suppression of punished responding produced by CRF and amphetamine in a dose-dependent manner. Chlordiazepoxide, which produced a release of punished responding by itself, also reversed the suppression of punished responding produced by CRF but not that of amphetamine. The benzodiazepine inverse agonist FG 7142, in contrast, enhanced the rate suppressing actions of both CRF and amphetamine. In a locomotor activity test, Ro 15-1788 failed to block the locomotor activation observed with CRF and amphetamine. The results suggest that "anxiety" or stress-enhancing compounds may enhance the partial agonist properties of Ro 15-1788 in certain test situations. JF - Psychopharmacology AU - Britton, K T AU - Lee, G AU - Koob, G F AD - Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92161. Y1 - 1988 PY - 1988 DA - 1988 SP - 306 EP - 311 VL - 94 IS - 3 SN - 0033-3158, 0033-3158 KW - Carbolines KW - 0 KW - Flumazenil KW - 40P7XK9392 KW - FG 7142 KW - 60PO70N1BP KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Drug Interactions KW - Chlordiazepoxide -- pharmacology KW - Motor Activity -- drug effects KW - Carbolines -- pharmacology KW - Male KW - Behavior, Animal -- drug effects KW - Conflict (Psychology) KW - Corticotropin-Releasing Hormone -- pharmacology KW - Amphetamine -- pharmacology KW - Flumazenil -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78174847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Corticotropin+releasing+factor+and+amphetamine+exaggerate+partial+agonist+properties+of+benzodiazepine+antagonist+Ro+15-1788+in+the+conflict+test.&rft.au=Britton%2C+K+T%3BLee%2C+G%3BKoob%2C+G+F&rft.aulast=Britton&rft.aufirst=K&rft.date=1988-01-01&rft.volume=94&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-13 N1 - Date created - 1988-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enterococcal superinfection in patients treated with ciprofloxacin. AN - 78167886; 3128516 AB - Two patients developed serious enterococcal superinfection following therapy with intravenous ciprofloxacin. The strains causing bacteraemia were susceptible to low concentrations of ciprofloxacin when tested at a standard inoculum. However, at an inoculum of 1 X 10(7) cfu/ml they were resistant to high concentrations of ciprofloxacin. Our data suggest that ciprofloxacin should not be used to treat patients with serious enterococcal infection and that patients treated with ciprofloxacin should be monitored carefully for the development of enterococcal superinfection. JF - The Journal of antimicrobial chemotherapy AU - Zervos, M J AU - Bacon, A E AU - Patterson, J E AU - Schaberg, D R AU - Kauffman, C A AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, MI. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 113 EP - 115 VL - 21 IS - 1 SN - 0305-7453, 0305-7453 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Index Medicus KW - Pseudomonas Infections -- drug therapy KW - Humans KW - Pseudomonas Infections -- complications KW - Adult KW - Enterococcus faecalis KW - Sepsis -- drug therapy KW - Aged KW - Sepsis -- microbiology KW - Male KW - Kidney Failure, Chronic -- complications KW - Streptococcal Infections -- etiology KW - Streptococcal Infections -- microbiology KW - Ciprofloxacin -- therapeutic use KW - Ciprofloxacin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78167886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Enterococcal+superinfection+in+patients+treated+with+ciprofloxacin.&rft.au=Zervos%2C+M+J%3BBacon%2C+A+E%3BPatterson%2C+J+E%3BSchaberg%2C+D+R%3BKauffman%2C+C+A&rft.aulast=Zervos&rft.aufirst=M&rft.date=1988-01-01&rft.volume=21&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-16 N1 - Date created - 1988-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A review of human salmonellosis: III. Magnitude of Salmonella infection in the United States. AN - 78157439; 2832925 AB - National surveillance for salmonella infections was established in 1962, following recognition of the importance of Salmonella organisms as the cause of potentially preventable infectious disease in the United States. Reports of infections due to Salmonella have risen progressively to approximately 40,000 per year. In contrast, the parallel reporting system for infections due to Shigella shows no such increase. Because a passive surveillance system is used, it has been assumed salmonella infections have been substantially underreported. Three independent methods-determination of carriage rates, calculation of sequential surveillance artifacts, and calculation of overall surveillance artifact-were used to estimate the annual number of salmonella infections in the United States; the results were compared with those of a previous study. These methods produced estimates ranging from 800,000 to 3,700,000 (mean = 1,900,000; median = 1,400,000) infections annually. Accurate assessment of the number of infections is important for determining complication rates and for evaluating the efficacy of control programs. JF - Reviews of infectious diseases AU - Chalker, R B AU - Blaser, M J AD - Infectious Disease Section, Veterans Administration Medical Center, Denver, Colorado 80220. PY - 1988 SP - 111 EP - 124 VL - 10 IS - 1 SN - 0162-0886, 0162-0886 KW - Index Medicus KW - United States KW - MEDLARS KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Salmonella Food Poisoning -- epidemiology KW - Salmonella Infections -- epidemiology KW - Disease Outbreaks KW - Carrier State -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78157439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=A+review+of+human+salmonellosis%3A+III.+Magnitude+of+Salmonella+infection+in+the+United+States.&rft.au=Chalker%2C+R+B%3BBlaser%2C+M+J&rft.aulast=Chalker&rft.aufirst=R&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-06 N1 - Date created - 1988-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Event-related brain potentials in intoxicated and detoxified alcoholics during visuospatial learning. AN - 78149175; 3127856 AB - Event-related potentials and visuospatial learning performance were examined to understand the effects of chronic alcohol use on complex information processing. A total of 18 alcoholic male in-patients in an alcohol treatment program served as participants. Nine persons were seen at time of admission to the program while intoxicated (mean BAC = 18.0 mg/dl). The second group of nine persons was seen detoxified after 4 weeks in the treatment program. Learning consisted of a paired-associate paradigm requiring participants to learn the distinct spatial positions of six, randomly presented "nonsense" shapes. The visuospatial learning performance of the intoxicated alcoholics was superior to that of the detoxified alcoholics. Evaluation of event-related potentials during the visuospatial learning task indicated that while both groups displayed greater right hemisphere amplitudes of P3, P2, N1, and N2-P3 components, the amplitudes of the latter three components were significantly greater in the intoxicated alcoholics. The overall results suggest that compared to the intoxicated alcoholic, the detoxified alcoholic may suffer a disruption in attentional mechanisms related to visuospatial information processing, providing support for a theory that alcohol ingestion serves to balance information processing in the chronic alcoholic. JF - Psychopharmacology AU - Schandler, S L AU - Cohen, M J AU - McArthur, D L AD - Veterans Administration Medical Center, Long Beach, California. Y1 - 1988 PY - 1988 DA - 1988 SP - 275 EP - 283 VL - 94 IS - 2 SN - 0033-3158, 0033-3158 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Ethanol -- blood KW - Electrooculography KW - Humans KW - Electroencephalography KW - Adult KW - Middle Aged KW - Male KW - Learning KW - Alcoholism -- physiopathology KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78149175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Event-related+brain+potentials+in+intoxicated+and+detoxified+alcoholics+during+visuospatial+learning.&rft.au=Schandler%2C+S+L%3BCohen%2C+M+J%3BMcArthur%2C+D+L&rft.aulast=Schandler&rft.aufirst=S&rft.date=1988-01-01&rft.volume=94&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-03 N1 - Date created - 1988-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 2,4-D-n-butyl ester (2,4-D ester) induced ataxia in rats: role for n-butanol formation. AN - 78148109; 3352573 AB - Three formulations of 2,4-D were tested in rats for their ability to increase landing foot splay, a measure of ataxia. When administered for three to four consecutive days, 2,4-D-n-butyl ester (150 mg/kg/day SC) produced significant increases in landing foot splay while 2,4-D acid (120 mg/kg/day SC) and 2,4-D mixed butyl esters (150 mg/kg/day SC) did not. The ability of acute n-butanol, 2-butanol, and a 50:50 mixture of both (2.13 mM/kg SC) to increase landing foot splay was then assessed. Only n-butanol significantly increased landing foot splay. Similarly, when n-butanol was administered daily, at doses corresponding to 150 mg/kg/day of the 2,4-D-n-butyl ester, significant increases in landing foot splay were evident. The pattern of splay increases was remarkably similar to that observed for 2,4-D-n-butyl ester. When locomotor activity was the dependent variable, daily n-butanol had no effect. These results suggest that in vivo formation of n-butanol after administration of 2,4-D-n-butyl ester is responsible for the motor incoordination but not the depression of locomotor activity observed following 2,4-D-n-butyl ester administration. These data demonstrate that different formulations of the same herbicide can produce differential behavioral effects. JF - Neurotoxicology and teratology AU - Schulze, G E AD - Research Service, Veterans Administration Medical Center, Lexington, KY 40511. PY - 1988 SP - 81 EP - 84 VL - 10 IS - 1 SN - 0892-0362, 0892-0362 KW - Butanols KW - 0 KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - 1-Butanol KW - 8PJ61P6TS3 KW - 2,4-D n-butyl ester KW - 94-80-4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Motor Activity -- drug effects KW - Male KW - Butanols -- toxicity KW - Ataxia -- chemically induced KW - Butanols -- metabolism KW - 2,4-Dichlorophenoxyacetic Acid -- metabolism KW - 2,4-Dichlorophenoxyacetic Acid -- toxicity KW - 2,4-Dichlorophenoxyacetic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78148109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=2%2C4-D-n-butyl+ester+%282%2C4-D+ester%29+induced+ataxia+in+rats%3A+role+for+n-butanol+formation.&rft.au=Schulze%2C+G+E&rft.aulast=Schulze&rft.aufirst=G&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-04 N1 - Date created - 1988-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurobehavioral toxicity of 2,4-D-n-butyl ester (2,4-D ester): tolerance and lack of cross-tolerance. AN - 78147884; 3352572 AB - Daily administration of 2,4-dichlorophenoxyacetic acid-n-butyl ester to rats (2,4-D ester, 150 mg/kg/day SC) initially produced depressions in photocell locomotor activity and increases in landing foot splay. Maximal tolerance developed to these effects following ten days of repeated exposure. By themselves, physostigmine sulfate (0.01-0.10 mg/kg) and (0.3-10.0 mg/kg) n-butanol produced locomotor activity depression in a dose-related manner. n-Butanol produced increases in landing foot splay while physostigmine had no effect at the doses employed. No cross-tolerance was observed between 2,4-D ester and physostigmine sulfate or n-butanol when locomotor activity was the dependent variable. Similarly, a lack of cross-tolerance was observed between 2,4-D ester and n-butanol when landing foot splay was measured. Unlike physostigmine, prior exposure to n-butanol tended to enhance its toxicity upon subsequent exposures, an effect which was blocked when 2,4-D ester was administered between n-butanol exposures. JF - Neurotoxicology and teratology AU - Schulze, G E AU - Dougherty, J A AD - Research Service, Veterans Administration Medical Center, Lexington, KY 40511. PY - 1988 SP - 75 EP - 79 VL - 10 IS - 1 SN - 0892-0362, 0892-0362 KW - Butanols KW - 0 KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - 1-Butanol KW - 8PJ61P6TS3 KW - 2,4-D n-butyl ester KW - 94-80-4 KW - Physostigmine KW - 9U1VM840SP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Drug Tolerance KW - Animals KW - Butanols -- toxicity KW - Dose-Response Relationship, Drug KW - Physostigmine -- pharmacology KW - Male KW - Motor Activity -- drug effects KW - 2,4-Dichlorophenoxyacetic Acid -- toxicity KW - 2,4-Dichlorophenoxyacetic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78147884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Neurobehavioral+toxicity+of+2%2C4-D-n-butyl+ester+%282%2C4-D+ester%29%3A+tolerance+and+lack+of+cross-tolerance.&rft.au=Schulze%2C+G+E%3BDougherty%2C+J+A&rft.aulast=Schulze&rft.aufirst=G&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-04 N1 - Date created - 1988-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amdinocillin: interaction with other beta-lactam antibiotics for gram-negative bacteria. AN - 78142895; 3258230 AB - Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose. JF - Chemotherapy AU - Eng, R H AU - Liu, R AU - Smith, S M AU - Johnson, E S AU - Cherubin, C E AD - Veterans Administration Medical Center, East Orange, N.J. Y1 - 1988 PY - 1988 DA - 1988 SP - 18 EP - 26 VL - 34 IS - 1 SN - 0009-3157, 0009-3157 KW - Anti-Bacterial Agents KW - 0 KW - beta-Lactamases KW - EC 3.5.2.6 KW - Amdinocillin KW - V10579P3QZ KW - Index Medicus KW - beta-Lactamases -- biosynthesis KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Anti-Bacterial Agents -- pharmacology KW - Amdinocillin -- pharmacology KW - Gram-Negative Bacteria -- drug effects KW - Gram-Negative Bacteria -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78142895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Amdinocillin%3A+interaction+with+other+beta-lactam+antibiotics+for+gram-negative+bacteria.&rft.au=Eng%2C+R+H%3BLiu%2C+R%3BSmith%2C+S+M%3BJohnson%2C+E+S%3BCherubin%2C+C+E&rft.aulast=Eng&rft.aufirst=R&rft.date=1988-01-01&rft.volume=34&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Chemotherapy&rft.issn=00093157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-28 N1 - Date created - 1988-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differences in psychological need hierarchies between black and white drug addicts. AN - 78129245; 3343370 AB - A total of 109 Black and White heroin and cocaine addicts in treatment for drug abuse were compared on the Adjective Checklist (ACL). We found that the White addict had a significantly different pattern of needs than did the Black addict, characterized by more psychological dependence, distress, and maladjustment. Consistent with the MMPI literature in this area, the ACL provides an accurate evaluation of personality dimensions among drug addicts, and White addicts are more psychologically maladjusted than Black addicts. JF - Journal of clinical psychology AU - Craig, R J AU - Olson, R E AD - West Side Veterans Administration Medical Center, Chicago. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 82 EP - 86 VL - 44 IS - 1 SN - 0021-9762, 0021-9762 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Psychometrics KW - Male KW - Personality Tests KW - African Americans -- psychology KW - Substance-Related Disorders -- psychology KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78129245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Differences+in+psychological+need+hierarchies+between+black+and+white+drug+addicts.&rft.au=Craig%2C+R+J%3BOlson%2C+R+E&rft.aulast=Craig&rft.aufirst=R&rft.date=1988-01-01&rft.volume=44&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A structured diagnostic interview for identification of primary alcoholism: a preliminary evaluation. AN - 78125323; 3347082 AB - Forty alcoholic inpatient men were used to evaluate the test-retest reliability and the validity of a new structured diagnostic interview. The Alcohol Research Center (ARC) Intake Interview was constructed from the Schedule of Affective Disorders and Schizophrenia (SADS) parts I and II and from the Diagnostic Interview Schedule family history section by extracting information on diagnoses most likely to be seen in alcoholic patients and by expanding the data set with questions relevant to alcohol and drug use. The test-retest reliability for patients' primary and secondary diagnoses included a kappa of 1.00 for the comparison of interviewers A and B (100% agreement) and of .76 for interviewers A and C. The validity of ARC Intake Interview patient diagnoses as compared to the SADS demonstrated an overall agreement between 91 and 100%. Reliabilities for labeling of families as positive or negative for specific illness in any first-degree relatives revealed a kappa of 1.00; validities on family diagnoses ranged from 77 to 100%, with the ARC Intake Interview identifying more illness in families than the SADS. Although further evaluation of the ARC Intake Interview is needed, this instrument is recommended to investigators attempting to evaluate the clinical course and treatment needs among alcoholics, especially those patients presenting with multiple diagnoses. JF - Journal of studies on alcohol AU - Schuckit, M A AU - Irwin, M AU - Howard, T AU - Smith, T AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 93 EP - 99 VL - 49 IS - 1 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Interview, Psychological KW - Humans KW - Adult KW - Middle Aged KW - Psychometrics KW - Male KW - Psychiatric Status Rating Scales KW - Alcoholism -- diagnosis KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78125323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=A+structured+diagnostic+interview+for+identification+of+primary+alcoholism%3A+a+preliminary+evaluation.&rft.au=Schuckit%2C+M+A%3BIrwin%2C+M%3BHoward%2C+T%3BSmith%2C+T&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1988-01-01&rft.volume=49&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Welders' pneumoconiosis: tissue elemental microanalysis by energy dispersive x ray analysis. AN - 78114305; 3342182 AB - Histological examination on lung tissue obtained from 10 symptomatic welders was performed by two certified pathologists without the knowledge of the patients' clinical condition. In all cases, there was some degree of interstitial fibrosis; in five the degree of fibrosis was considered to be moderate to pronounced. The tissue was also analysed by energy dispersive x ray analysis and elemental contents were compared with age matched controls. There was a large amount of iron in the lungs of welders but the silicon content did not differ from the control subjects. No specific foreign element was detected. It is concluded that (1) interstitial pulmonary fibrosis is seen in some welders and (2) the cause of fibrosis does not appear to be coexisting silicosis. JF - British journal of industrial medicine AU - Funahashi, A AU - Schlueter, D P AU - Pintar, K AU - Bemis, E L AU - Siegesmund, K A AD - Department of Medicine, Clement J Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 14 EP - 18 VL - 45 IS - 1 SN - 0007-1072, 0007-1072 KW - Iron KW - E1UOL152H7 KW - Silicon KW - Z4152N8IUI KW - Index Medicus KW - Electron Probe Microanalysis KW - Iron -- analysis KW - Pulmonary Fibrosis -- pathology KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Silicon -- analysis KW - Lung -- analysis KW - Welding KW - Pneumoconiosis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78114305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+industrial+medicine&rft.atitle=Welders%27+pneumoconiosis%3A+tissue+elemental+microanalysis+by+energy+dispersive+x+ray+analysis.&rft.au=Funahashi%2C+A%3BSchlueter%2C+D+P%3BPintar%2C+K%3BBemis%2C+E+L%3BSiegesmund%2C+K+A&rft.aulast=Funahashi&rft.aufirst=A&rft.date=1988-01-01&rft.volume=45&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=British+journal+of+industrial+medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-31 N1 - Date created - 1988-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1956 Apr;44(4):806-12 [13303049] Arch Environ Health. 1967 Oct;15(4):462-9 [6054570] Am Rev Respir Dis. 1971 Jan;103(1):57-67 [5540840] Arch Environ Health. 1974 Jun;28(6):345-9 [4597741] Arch Environ Health. 1975 Jun;30(6):285-9 [1094963] Am Ind Hyg Assoc J. 1977 Feb;38(2):76-82 [848429] Am Rev Respir Dis. 1961 Dec;84:789-806 [13875021] Arch Environ Health. 1978 May-Jun;33(3):117-24 [686834] Chest. 1984 Apr;85(4):506-9 [6705580] J Am Med Assoc. 1953 Aug 15;152(16):1520-2 [13061312] Am Rev Tuberc. 1955 Jun;71(6):877-84 [14376804] Ann Intern Med. 1961 Jan;54:121-7 [13701945] J Postgrad Med. 1977 Jan;23(1):35-8 [615258] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Back pain in health care workers. AN - 78098474; 2963392 AB - The health care industry includes several occupations for which the incidence of back pain is unusually high. The authors review the epidemiology, potential causes and possible interventions in this setting. JF - Occupational medicine (Philadelphia, Pa.) AU - Kaplan, R M AU - Deyo, R A AD - Health Services Research and Development, Seattle Veterans Administration Medical Center, WA 98108. PY - 1988 SP - 61 EP - 73 VL - 3 IS - 1 SN - 0885-114X, 0885-114X KW - Index Medicus KW - United States KW - Humans KW - Back Pain -- epidemiology KW - Nurses KW - Occupational Diseases -- epidemiology KW - Health Manpower UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78098474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Back+pain+in+health+care+workers.&rft.au=Kaplan%2C+R+M%3BDeyo%2C+R+A&rft.aulast=Kaplan&rft.aufirst=R&rft.date=1988-01-01&rft.volume=3&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of renal injury initiated by immunization of rats with heparan sulfate. AN - 78096590; 2962503 AB - To investigate the role of antibody to heparan sulfate (HS) in the development of glomerular injury, male Lewis rats were immunized with HS and compared with unimmunized controls. In HS-immunized rats circulating antibodies that bound to renal basement membranes, an increase in serum creatinine (0.8 mg/dl versus 0.6 in controls P less than 0.01), and a 40% decline in creatinine clearance developed. In no animal did abnormal proteinuria develop. By histologic examination there was glomerular and interstitial capillary engorgement with erythrocytes, modest infiltration by polymorphonuclear leukocytes, and no proliferation of intrinsic glomerular cells. Immunofluorescence microscopy demonstrated deposits of rat IgG along the glomerular basement membrane. Bowman's capsule, and peritubular capillaries. Electron-microscopic examination revealed capillary engorgement with erythrocytes that appeared adherent to each other and contained entrapped areas of rarefied material. These observations demonstrate that binding of antibody to HS in the glomerulus induces a mild inflammatory reaction and a reduction in glomerular filtration rate, but no abnormal proteinuria. JF - The American journal of pathology AU - Abrass, C K AU - Cohen, A H AD - Division of Nephrology, Veterans Administration Medical Center, Seattle, WA 98108. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 103 EP - 111 VL - 130 IS - 1 SN - 0002-9440, 0002-9440 KW - Glycosaminoglycans KW - 0 KW - Immunoglobulin G KW - Heparitin Sulfate KW - 9050-30-0 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Basement Membrane -- ultrastructure KW - Animals KW - Rats, Inbred Lew KW - Immunoglobulin G -- analysis KW - Erythrocytes -- cytology KW - Antibody Formation KW - Microscopy, Electron KW - Kidney Glomerulus -- ultrastructure KW - Kidney Glomerulus -- pathology KW - Fluorescent Antibody Technique KW - Male KW - Erythrocytes -- immunology KW - Glycosaminoglycans -- toxicity KW - Kidney -- pathology KW - Heparitin Sulfate -- immunology KW - Kidney -- drug effects KW - Kidney -- immunology KW - Heparitin Sulfate -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Characterization+of+renal+injury+initiated+by+immunization+of+rats+with+heparan+sulfate.&rft.au=Abrass%2C+C+K%3BCohen%2C+A+H&rft.aulast=Abrass&rft.aufirst=C&rft.date=1988-01-01&rft.volume=130&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-25 N1 - Date created - 1988-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1985 Jun;134(6):3831-7 [2985699] Kidney Int. 1983 Jun;23(6):855-61 [6136625] J Clin Invest. 1986 Jan;77(1):142-56 [2935558] Kidney Int. 1985 Dec;28(6):879-90 [2935674] J Exp Med. 1986 May 1;163(5):1064-84 [2939168] J Immunol. 1986 Jul 15;137(2):530-5 [3487574] AMA Arch Pathol. 1951 Jun;51(6):629-39 [14829136] J Biol Chem. 1961 Apr;236:983-7 [13747650] J Exp Med. 1965 May 1;121:697-714 [14278226] J Exp Med. 1967 Dec 1;126(6):989-1004 [4964566] Nature. 1970 Aug 15;227(5259):680-5 [5432063] J Cell Biol. 1975 Dec;67(3):638-46 [1202017] J Immunol. 1977 May;118(5):1788-94 [16060] Proc Soc Exp Biol Med. 1977 Oct;156(1):162-7 [909885] J Am Vet Med Assoc. 1977 Nov 1;171(9):842-4 [924855] Biochem Biophys Res Commun. 1978 Feb 28;80(4):805-12 [147687] Biochem J. 1978 Jun 15;172(3):443-56 [687354] Proc Natl Acad Sci U S A. 1979 Mar;76(3):1303-7 [155819] Lab Invest. 1980 Feb;42(2):190-6 [7354613] J Reticuloendothel Soc. 1980 Apr;27(4):383-91 [6768884] Lab Invest. 1980 Jul;43(1):18-27 [6446622] J Cell Biol. 1980 Aug;86(2):688-93 [6447156] Proc Natl Acad Sci U S A. 1980 Aug;77(8):4494-8 [6449008] J Exp Med. 1982 Jul 1;156(1):128-45 [7086353] Kidney Int. 1982 Apr;21(4):565-74 [7098274] Virchows Arch B Cell Pathol Incl Mol Pathol. 1982;39(3):305-21 [6126036] Biochim Biophys Acta. 1983 Jul 5;758(1):70-83 [6222769] Lab Invest. 1983 Jul;49(1):38-47 [6865329] J Biol Chem. 1985 Jul 15;260(14):8564-70 [2409091] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Influence of portal hemodynamics on long-term survival of alcoholic cirrhotic patients after small-diameter portacaval H grafts. AN - 78096140; 3341529 AB - Estimating postoperative survival rates after portasystemic shunt procedures has concerned surgeons during the last 40 years. The relationship between survival and Child's classification has clearly demonstrated the importance of preoperative hepatic functional reserve. Maintaining hepatic portal perfusion has been proposed as an additional protective factor but has never been proved clinically. Our analysis of survival after partial shunting with small-diameter portacaval H grafts has shown that both hepatic functional reserve and postoperative portal perfusion correlate with postoperative survival in alcoholic patients, but the latter was a stronger correlate of long-term survival. A predictive model based on both factors has been described for estimating the overall survival rate of alcoholics after partial shunting with small-diameter portacaval H grafts. JF - American journal of surgery AU - Rypins, E B AU - Sarfeh, I J AD - Surgical Service, Long Beach Veterans Administration Medical Center. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 152 EP - 158 VL - 155 IS - 1 SN - 0002-9610, 0002-9610 KW - Abridged Index Medicus KW - Index Medicus KW - Blood Pressure KW - Humans KW - Portal System -- physiopathology KW - Actuarial Analysis KW - Portacaval Shunt, Surgical KW - Liver Circulation KW - Liver Cirrhosis, Alcoholic -- physiopathology KW - Liver Cirrhosis, Alcoholic -- mortality KW - Liver Cirrhosis, Alcoholic -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+surgery&rft.atitle=Influence+of+portal+hemodynamics+on+long-term+survival+of+alcoholic+cirrhotic+patients+after+small-diameter+portacaval+H+grafts.&rft.au=Rypins%2C+E+B%3BSarfeh%2C+I+J&rft.aulast=Rypins&rft.aufirst=E&rft.date=1988-01-01&rft.volume=155&rft.issue=1&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=American+journal+of+surgery&rft.issn=00029610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Influence of diabetes on susceptibility to experimental pancreatic cancer. AN - 78096060; 2963553 AB - Clinical studies suggest that diabetes mellitus may predispose to the development of pancreatic cancer. The current study investigated the effect of experimental diabetes on the susceptibility of the Syrian hamster to the induction of exocrine pancreatic carcinoma by the carcinogen BOP. Diabetes was induced with the B-cell toxin streptozotocin. Three groups of animals were studied: nondiabetic control animals and animals with streptozotocin-induced diabetes, and a third group of animals in which the diabetogenic effect of streptozotocin was blocked with nicotinamide. Streptozotocin-induced diabetes significantly inhibited the induction of pancreatic carcinoma by BOP, decreasing the incidence of carcinoma to 24 percent compared with an incidence of 75 percent in nondiabetic control animals (p less than 0.002). In diabetic animals, the degree of inhibition of carcinogenesis paralleled the severity of the diabetes. Blocking the diabetogenic effect of streptozotocin with nicotinamide restored the incidence of induced invasive pancreatic carcinoma to that occurring in nondiabetic control animals. In the hamster model, diabetes appears to have a strong influence on susceptibility to the development of pancreatic carcinoma. JF - American journal of surgery AU - Bell, R H AU - McCullough, P J AU - Pour, P M AD - Department of Surgery, Veterans Administration Medical Center, Cincinnati, Ohio 45220. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 159 EP - 164 VL - 155 IS - 1 SN - 0002-9610, 0002-9610 KW - Blood Glucose KW - 0 KW - Nitrosamines KW - Niacinamide KW - 25X51I8RD4 KW - Streptozocin KW - 5W494URQ81 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Niacinamide -- pharmacology KW - Disease Susceptibility KW - Mesocricetus KW - Blood Glucose -- analysis KW - Male KW - Cricetinae KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- blood KW - Pancreatic Neoplasms -- chemically induced KW - Diabetes Mellitus, Experimental -- blood KW - Diabetes Mellitus, Experimental -- complications KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+surgery&rft.atitle=Influence+of+diabetes+on+susceptibility+to+experimental+pancreatic+cancer.&rft.au=Bell%2C+R+H%3BMcCullough%2C+P+J%3BPour%2C+P+M&rft.aulast=Bell&rft.aufirst=R&rft.date=1988-01-01&rft.volume=155&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=American+journal+of+surgery&rft.issn=00029610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Altered conversion of tryptophan to kynurenine in newly abstinent alcoholics. AN - 78094430; 3337856 JF - Biological psychiatry AU - Friedman, M J AU - Krstulovic, A M AU - Severinghaus, J M AU - Brown, S J AD - Veterans Administration Hospital, White River Junction, VT 05001. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 89 EP - 93 VL - 23 IS - 1 SN - 0006-3223, 0006-3223 KW - Serotonin KW - 333DO1RDJY KW - Kynurenine KW - 343-65-7 KW - Tryptophan KW - 8DUH1N11BX KW - Tryptophan Oxygenase KW - EC 1.13.11.11 KW - Index Medicus KW - Liver -- enzymology KW - Humans KW - Adult KW - Tryptophan Oxygenase -- antagonists & inhibitors KW - Male KW - Alcoholism -- rehabilitation KW - Kynurenine -- blood KW - Alcoholism -- enzymology KW - Tryptophan -- administration & dosage KW - Serotonin -- blood KW - Tryptophan -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78094430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Altered+conversion+of+tryptophan+to+kynurenine+in+newly+abstinent+alcoholics.&rft.au=Friedman%2C+M+J%3BKrstulovic%2C+A+M%3BSeveringhaus%2C+J+M%3BBrown%2C+S+J&rft.aulast=Friedman&rft.aufirst=M&rft.date=1988-01-01&rft.volume=23&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of histamine release from canine fundic mucosal mast cells. AN - 78093827; 2962515 AB - To study the control of histamine release, we developed techniques for culturing fundic mucosal mast cells. After enzyme dispersion, enrichment by elutriation, and overnight suspension culture, mast cells accounted for 30% of the cells present. Histamine release into the medium, measured by radioenzymatic assay, was stimulated by the lectin concanavalin A (Con A). Ragweed antigen released histamine in antisera-sensitized cultures. Con A-induced histamine release was enhanced by adenosine, but adenosine alone was inactive. The relative potency of adenosine analogues was consistent with interaction at an adenosine A1-receptor site. The calcium ionophore A23187 (0.1-1 microM) also induced histamine release. Phorbol esters that activate protein kinase C, such as phorbol 12-myristate 13-acetate, did not release histamine but enhanced release when added to low concentrations of A23187. In contrast, inactive phorbols, such as 4 alpha-phorbol 12,13-didecanoate, failed to enhance A23187-induced release. Parallel studies with canine hepatic mast cells yielded comparable results. We conclude that canine fundic mast cells possess receptors for immunoglobulin E and adenosine. Our data are consistent with increases in cytosolic calcium and protein kinase C activation working synergistically to stimulate fundic mast cells. JF - The American journal of physiology AU - Soll, A H AU - Toomey, M AU - Culp, D AU - Shanahan, F AU - Beaven, M A AD - Center for Ulcer Research and Education, Veterans Administration Wadsworth Hospital Center, Los Angeles, California. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - G40 EP - G48 VL - 254 IS - 1 Pt 1 SN - 0002-9513, 0002-9513 KW - Gastrins KW - 0 KW - Parasympathomimetics KW - Receptors, Fc KW - Receptors, IgE KW - Concanavalin A KW - 11028-71-0 KW - Calcimycin KW - 37H9VM9WZL KW - Histamine KW - 820484N8I3 KW - Adenosine KW - K72T3FS567 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Liver -- cytology KW - Liver -- metabolism KW - Calcimycin -- pharmacology KW - Receptors, Fc -- metabolism KW - Calcium -- metabolism KW - Adenosine -- pharmacology KW - Parasympathomimetics -- pharmacology KW - Cells, Cultured KW - Extracellular Space -- metabolism KW - Dogs KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gastrins -- pharmacology KW - Concanavalin A -- pharmacology KW - Gastric Fundus -- cytology KW - Mast Cells -- metabolism KW - Histamine -- metabolism KW - Gastric Fundus -- metabolism KW - Gastric Mucosa -- cytology KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78093827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Modulation+of+histamine+release+from+canine+fundic+mucosal+mast+cells.&rft.au=Soll%2C+A+H%3BToomey%2C+M%3BCulp%2C+D%3BShanahan%2C+F%3BBeaven%2C+M+A&rft.aulast=Soll&rft.aufirst=A&rft.date=1988-01-01&rft.volume=254&rft.issue=1+Pt+1&rft.spage=G40&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol esters inhibit adenylate cyclase activity in cultured collecting tubular cells. AN - 78091578; 3337216 AB - Activators of protein kinase C, a calcium- and phospholipid-dependent protein kinase, inhibit vasopressin-stimulated water flow in toad bladder. To determine the biochemical mechanisms of this inhibition, we examined the effects of activators of protein kinase C on arginine vasopressin (AVP)-stimulated adenylate cyclase activity in cultured rabbit cortical collecting tubular cells. The phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA), the diacylglycerol, 1-oleyl-2-acetyl glycerol (OAG), and the diacylglycerol kinase inhibitor, R59022, all rapidly activate protein kinase C in collecting tubular cells. Pretreatment with PMA produces a delayed inhibition (greater than or equal to 4 h) of AVP-stimulated adenylate cyclase activity. The 4-h time lag suggests that the effects of protein kinase C are mediated indirectly, possibly as a consequence of stimulating cell proliferation. PMA does not inhibit cholera toxin- or forskolin-stimulated adenylate cyclase activity, suggesting an effect on the vasopressin receptor or coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. Neither prostaglandins nor the inhibitory guanine nucleotide regulatory protein appear to mediate this effect. In contrast, treatment with either OAG or R59022 produces a rapid inhibition of both AVP- and forskolin-stimulated adenylate cyclase activity suggesting a prominent distal site of action, presumably at the catalytic subunit of adenylate cyclase. The results demonstrate that different activators of protein kinase C inhibit AVP-stimulated adenylate cyclase activity by distinctly different mechanisms possibly by altering the substrate specificity or activating multiple forms of the kinase. These results have important implications when using different activators to study the biological effects of protein kinase C. JF - The American journal of physiology AU - Dixon, B S AU - Breckon, R AU - Burke, C AU - Anderson, R J AD - Department of Medicine, Veterans Administration Hospital, Denver, Colorado. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - C183 EP - C191 VL - 254 IS - 1 Pt 1 SN - 0002-9513, 0002-9513 KW - Adenylyl Cyclase Inhibitors KW - 0 KW - Diglycerides KW - Phorbol Esters KW - Pyrimidinones KW - Thiazoles KW - Vasopressins KW - 11000-17-2 KW - 1-oleoyl-2-acetylglycerol KW - 86390-77-4 KW - R 59022 KW - 93076-89-2 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Thiazoles -- pharmacology KW - Stimulation, Chemical KW - Protein Kinase C -- metabolism KW - Animals KW - Diglycerides -- pharmacology KW - Cells, Cultured KW - Pyrimidinones -- pharmacology KW - Adenylyl Cyclases -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Vasopressins -- pharmacology KW - Rabbits KW - Phorbol Esters -- pharmacology KW - Kidney Tubules -- enzymology KW - Kidney Tubules, Collecting -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78091578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Phorbol+esters+inhibit+adenylate+cyclase+activity+in+cultured+collecting+tubular+cells.&rft.au=Dixon%2C+B+S%3BBreckon%2C+R%3BBurke%2C+C%3BAnderson%2C+R+J&rft.aulast=Dixon&rft.aufirst=B&rft.date=1988-01-01&rft.volume=254&rft.issue=1+Pt+1&rft.spage=C183&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quality assurance. AN - 78088520; 3339564 AB - The QA process is recommended to anyone seeking to upgrade patient care delivery. It clarifies theories and gives substance to progressive ideas being considered for adoption. Certainly it tends to prevent premature and ill-conceived presentations. When an action is instituted, QA provides the framework that can be used to facilitate the change. As an afterthought, but as a welcome benefit, QA can foster teamwork and camaraderie among staff who assist in problem solving or bringing an idea to fruition. JF - Journal of psychosocial nursing and mental health services AU - Latreille, D D AU - Roth, M J AU - Burgoyne, J A AD - Ann Arbor Veterans Administration Medical Center, Alcohol Rehabilitation Unit, Michigan 48105. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 28 EP - 31 VL - 26 IS - 1 SN - 0279-3695, 0279-3695 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Nursing KW - Alcoholism -- rehabilitation KW - Nursing Staff, Hospital KW - Self Administration KW - Disulfiram -- administration & dosage KW - Humans KW - Patient Education as Topic KW - Quality Assurance, Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78088520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=Quality+assurance.&rft.au=Latreille%2C+D+D%3BRoth%2C+M+J%3BBurgoyne%2C+J+A&rft.aulast=Latreille&rft.aufirst=D&rft.date=1988-01-01&rft.volume=26&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-15 N1 - Date created - 1988-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dental management of the cocaine addict. AN - 78086151; 2963248 AB - Addiction to cocaine is a growing problem in the United States. The detrimental physiologic aspects of addiction require that certain precautions be observed during dental care to avoid a morbid reaction or a possible fatality. The adverse psychological and social aspects of addiction must also be understood by the dentist in order to properly manage this troubled group of patients. JF - Oral surgery, oral medicine, and oral pathology AU - Friedlander, A H AU - Gorelick, D A AD - Dental Service, Brentwood Division, West Los Angeles Veterans Administration Medical Center, Calif. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 45 EP - 48 VL - 65 IS - 1 SN - 0030-4220, 0030-4220 KW - Cocaine KW - I5Y540LHVR KW - Dentistry KW - Index Medicus KW - Humans KW - Substance-Related Disorders KW - Dental Care for Disabled UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78086151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+surgery%2C+oral+medicine%2C+and+oral+pathology&rft.atitle=Dental+management+of+the+cocaine+addict.&rft.au=Friedlander%2C+A+H%3BGorelick%2C+D+A&rft.aulast=Friedlander&rft.aufirst=A&rft.date=1988-01-01&rft.volume=65&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Oral+surgery%2C+oral+medicine%2C+and+oral+pathology&rft.issn=00304220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-10 N1 - Date created - 1988-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychiatric disorders in the elderly. Psychopharmacologic management. AN - 78083693; 3336612 AB - Psychiatric management of elderly patients is a challenging task because of the many age-related physiologic changes and medical problems in this population. Thorough patient evaluation is essential to rule out somatic disorders and determine underlying causes. Somatic complaints must be taken seriously, even if a patient is receiving treatment for a psychiatric disorder. Psychotropic therapy is used mainly for controlling depression, agitation, and psychotic symptoms. If psychiatric symptoms persist or become worse, psychotropics should be discontinued to prevent possible drug toxicity (eg, anticholinergic delirium) and psychiatric consultation should be requested. JF - Postgraduate medicine AU - Tobias, C R AU - Turns, D M AU - Lippmann, S AU - Pary, R AU - Embry, C K AD - Veterans Administration Medical Center, Louisville, KY 40202. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 313 EP - 319 VL - 83 IS - 1 SN - 0032-5481, 0032-5481 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Alcoholism -- drug therapy KW - Anxiety Disorders -- drug therapy KW - Aged -- psychology KW - Depression -- drug therapy KW - Dementia -- drug therapy KW - Psychotic Disorders -- drug therapy KW - Delirium -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78083693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Psychiatric+disorders+in+the+elderly.+Psychopharmacologic+management.&rft.au=Tobias%2C+C+R%3BTurns%2C+D+M%3BLippmann%2C+S%3BPary%2C+R%3BEmbry%2C+C+K&rft.aulast=Tobias&rft.aufirst=C&rft.date=1988-01-01&rft.volume=83&rft.issue=1&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-18 N1 - Date created - 1988-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal salt wasting in patients treated with cisplatin. AN - 78082067; 3337511 AB - Although cisplatin nephrotoxicity is well documented, renal sodium wasting has rarely been reported. Seven of seventy patients treated with cisplatin over 18 months developed salt-wasting nephropathy and orthostatic hypotension. All patients presented 2 to 4 months after starting cisplatin with severe orthostatic hypotension (mean orthostatic change in blood pressure, -37 +/- 8 mm Hg) without preceding extrarenal volume loss or diuretic use. Urinary sodium concentration was 85 to 145 mmol/L, fractional excretion of sodium was 1.0% to 8.0%, and urinary osmolar concentration was 340 to 619 mmol/kg, while orthostatic hypotension was present. Six patients were hyponatremic (116 to 137 mmol/L). Serum creatinine and urea levels were elevated in five patients but fell after rehydration. Vasopressin averaged 5.4 pg/mL (2.1 to 12.7 pg/mL) (n = 5) and was suppressed with hydration (mean, 2.5 pg/mL, 1.5 to 4.3 pg/mL). Plasma renin activity was undetectable in two patients and low in three patients, and aldosterone was low in six patients despite clinical volume depletion. Cisplatin may produce renal salt wasting causing symptomatic orthostatic hypotension and hyponatremia associated with abnormalities of the renin-aldosterone system. JF - Annals of internal medicine AU - Hutchison, F N AU - Perez, E A AU - Gandara, D R AU - Lawrence, H J AU - Kaysen, G A AD - Department of Medicine, Martinez Veterans Administration Medical Center, California. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 21 EP - 25 VL - 108 IS - 1 SN - 0003-4819, 0003-4819 KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Humans KW - Hypotension, Orthostatic -- chemically induced KW - Aged KW - Middle Aged KW - Renin-Angiotensin System -- drug effects KW - Male KW - Natriuresis -- drug effects KW - Kidney Diseases -- metabolism KW - Water-Electrolyte Imbalance -- chemically induced KW - Cisplatin -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78082067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Renal+salt+wasting+in+patients+treated+with+cisplatin.&rft.au=Hutchison%2C+F+N%3BPerez%2C+E+A%3BGandara%2C+D+R%3BLawrence%2C+H+J%3BKaysen%2C+G+A&rft.aulast=Hutchison&rft.aufirst=F&rft.date=1988-01-01&rft.volume=108&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-18 N1 - Date created - 1988-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Albuterol has no effect on diaphragmatic fatigue in humans. AN - 78080973; 3337463 AB - Diaphragmatic fatigue may play an important role in precipitating acute respiratory failure. Pharmacologically, theophylline and beta-2 agonists have been used to improve diaphragmatic contractility. We designed experiments to study the effects of albuterol, a beta-2 agonist, on diaphragmatic fatigue in humans. In 5 normal subjects, fatigue was induced by breathing through an inspiratory resistance. Studies were done at 2 levels of diaphragmatic tension-time index (TTdi) of 0.25 and 0.30. At each TTdi, either placebo or albuterol (4 mg three times daily) was taken for 3 days. All subjects experienced side effects of sympathetic stimulation. Albuterol did not significantly increase the strength of the fresh diaphragm. With a TTdi of 0.25, values for mean endurance time were 649 +/- 250 (mean +/- SE) and 552 +/- 161 s, respectively, in placebo and albuterol runs. Respective values for TTdi of 0.30 were 109 +/- 14 and 143 +/- 27 s. During recovery, the mean values for the time needed for maximal transdiaphragmatic pressure (Pdimax) to reach 90% of the prefatigue Pdimax were 891 +/- 370 and 1043 +/- 394 s, respectively, for placebo and albuterol runs (TTdi = 0.25). Respective values for TTdi of 0.30 were 219 +/- 57 and 231 +/- 108 s. We conclude that, in humans, albuterol has no significant effect on the strength of the fresh or fatigued diaphragm, diaphragm endurance time, or the recovery of Pdimax from fatigue. JF - The American review of respiratory disease AU - Javaheri, S AU - Smith, J T AU - Thomas, J P AU - Guilfoile, T D AU - Donovan, E F AD - Pulmonary Section, Veterans Administration Medical Center, Cincinnati, OH 45220. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 197 EP - 201 VL - 137 IS - 1 SN - 0003-0805, 0003-0805 KW - Albuterol KW - QF8SVZ843E KW - Abridged Index Medicus KW - Index Medicus KW - Respiration KW - Humans KW - Adult KW - Electromyography KW - Male KW - Diaphragm -- drug effects KW - Diaphragm -- physiology KW - Albuterol -- pharmacology KW - Muscle Contraction -- drug effects KW - Albuterol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78080973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Albuterol+has+no+effect+on+diaphragmatic+fatigue+in+humans.&rft.au=Javaheri%2C+S%3BSmith%2C+J+T%3BThomas%2C+J+P%3BGuilfoile%2C+T+D%3BDonovan%2C+E+F&rft.aulast=Javaheri&rft.aufirst=S&rft.date=1988-01-01&rft.volume=137&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glutathione modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture. AN - 78078710; 3276218 AB - Cultured canine gastric chief cells exposed to a toxic oxygen metabolite-generating system (xanthine plus xanthine oxidase) demonstrated minimal cytolysis, suggesting that these cells have important endogenous antioxidant mechanisms. We have quantified the role of glutathione for protection against toxic oxygen metabolites by measuring cell lysis by lactate dehydrogenase release after variable depletion and repletion of cellular glutathione content. In the absence of exogenous oxidant stress, the glutathione content of chief cells can be depleted to less than 0.2 nmol total glutathione/micrograms DNA or 22% of control without cell lysis over 5 h. However, when challenged with the oxygen metabolite-generating system, cytolysis was greatly enhanced by glutathione depletion. Oxygen metabolite-mediated cytolysis after glutathione depletion was inhibited by exogenous catalase, thiourea, and deferoximine, but not superoxide dismutase or mannitol. These data suggested that hydrogen peroxide and hydroxyl radical mediated cytolysis in glutathione-depleted chief cells. If a substrate for glutathione synthesis, N-acetyl-L-cysteine, was provided to the depleted cells for 1 h before challenge with the oxygen radical-generating system, cell lysis was markedly decreased. However, if glutathione synthesis was blocked during the repletion period by buthionine sulfoximine, protection was not restored. The data supported an important role for glutathione as an endogenous antioxidant, which modulated the sensitivity of cultured chief cells to toxic oxygen metabolite injury. JF - The American journal of physiology AU - Olson, C E AD - Center for Ulcer Research and Education, Wadsworth Veterans Administration Medical Center, Los Angeles, California. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - G49 EP - G56 VL - 254 IS - 1 Pt 1 SN - 0002-9513, 0002-9513 KW - Antioxidants KW - 0 KW - Cytotoxins KW - Free Radicals KW - Maleates KW - Xanthines KW - Xanthine KW - 1AVZ07U9S7 KW - diethyl maleate KW - AK5N1DQX7U KW - Hydrogen Peroxide KW - BBX060AN9V KW - Xanthine Oxidase KW - EC 1.17.3.2 KW - Glutathione KW - GAN16C9B8O KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Xanthine Oxidase -- metabolism KW - Animals KW - Cytological Techniques KW - Enzyme Activation KW - Hydrogen Peroxide -- pharmacology KW - Cytotoxins -- pharmacology KW - Xanthines -- pharmacology KW - Maleates -- pharmacology KW - Antioxidants -- pharmacology KW - Cells, Cultured KW - Dogs KW - Xanthine Oxidase -- pharmacology KW - Time Factors KW - Stomach -- cytology KW - Stomach -- metabolism KW - Oxygen -- metabolism KW - Glutathione -- metabolism KW - Glutathione -- pharmacology KW - Stomach -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78078710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Glutathione+modulates+toxic+oxygen+metabolite+injury+of+canine+chief+cell+monolayers+in+primary+culture.&rft.au=Olson%2C+C+E&rft.aulast=Olson&rft.aufirst=C&rft.date=1988-01-01&rft.volume=254&rft.issue=1+Pt+1&rft.spage=G49&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Renal metabolic/excretory coupling. AN - 78078057; 3337242 AB - Renal metabolic/excretory coupling is the enhancement of urinary excretion dependent upon renal metabolism. The nitrofurothiazoles, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT), are model compounds used to study metabolic/excretory coupling. FANFT is deformylated to ANFT by renal deformylase enhancing ANFT excretion. In the rat, ANFT excretion after oral FANFT administration was 100-fold greater than ANFT excretion when ANFT was administered. FANFT and ANFT uptake into purified proximal tubules achieved equilibrium within 60 s and was demonstrated in nonviable tubules. FANFT partitioned into oil better than ANFT. Albumin inhibited FANFT and ANFT uptake into oil and decreased tubular uptake by 65%. Tubular FANFT uptake was threefold or greater than that of ANFT uptake with or without albumin. Renal deformylase was predominantly cytosolic and yielded apparent Km and Vmax of 6.7 microM and 6.1 nmol ANFT.min-1.mg protein-1, respectively. Deformylase activity was abolished by boiling, was specific for N-formylated compound, and was not altered by dinitrophenol treatment. Renal metabolic/excretory coupling for FANFT/ANFT combines energy-independent uptake with metabolism (deformylation), resulting in enhanced urinary ANFT excretion. JF - The American journal of physiology AU - Spry, L A AU - Rubinstein, J AU - Rettke, C AU - Zenser, T V AU - Davis, B B AD - Veterans Administration Medical Center, GRECC, St. Louis, MO 63125. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - F145 EP - F152 VL - 254 IS - 1 Pt 2 SN - 0002-9513, 0002-9513 KW - ANFT KW - 38514-71-5 KW - FANFT KW - 7N99PZG62O KW - p-Aminohippuric Acid KW - Y79XT83BJ9 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - FANFT -- pharmacokinetics KW - Kidney Tubules, Proximal -- metabolism KW - FANFT -- analogs & derivatives KW - Metabolic Clearance Rate KW - Rabbits KW - p-Aminohippuric Acid -- metabolism KW - Chromatography, High Pressure Liquid KW - Biological Availability KW - Kidney -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78078057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Renal+metabolic%2Fexcretory+coupling.&rft.au=Spry%2C+L+A%3BRubinstein%2C+J%3BRettke%2C+C%3BZenser%2C+T+V%3BDavis%2C+B+B&rft.aulast=Spry&rft.aufirst=L&rft.date=1988-01-01&rft.volume=254&rft.issue=1+Pt+2&rft.spage=F145&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-25 N1 - Date created - 1988-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence of immunologic control of lung injury induced by trimellitic anhydride. AN - 78077422; 3337461 AB - Trimellitic anhydride (TMA) is a chemical intermediate that has been shown to cause immunologically mediated respiratory syndromes in humans. We developed a rat model in which lung lesions accompanied by TMA-specific antibody resembled effects seen in humans. Two sets of experiments were undertaken to determine if TMA lung injury was primarily controlled by the immune system. Experiment 1: Rats were exposed to 95 micrograms/m3 of TMA 6 h/day, 5 days/wk for 2 wk during which time they received daily injections of either the immunosuppressant cyclophosphamide or saline. The TMA-exposed/saline control rats exhibited the usual TMA-induced lung lesions accompanied by TMA-specific antibody. However, the TMA-exposed/cyclophosphamide rats showed no lesions and no antibody. The spleen cells from all rats were subjected to lymphocyte blastogenesis assays using T- and B-cell mitogens. Results confirmed that cyclophosphamide-treated rats showed very little if any blastogenic response, whereas saline-treated rats gave the normal immune response. Thus, cyclophosphamide eliminated T- and B-cell function, which in turn prevented the occurrence of TMA lesions. Experiment 2: An initial passive transfer experiment showed that serum from TMA-sensitized rats could be adoptively transferred into naive recipient rats, which when given a single TMA inhalation challenge exhibited TMA-induced lesions. Similar attempts to transfer spleen cells or spleen cells plus serum did not predispose recipients for lesions. A second modified passive transfer of sensitized serum using a larger number of recipient rats, followed by a TMA challenge, resulted in lesions in 14 of the 16 rats.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Leach, C L AU - Hatoum, N S AU - Ratajczak, H V AU - Zeiss, C R AU - Garvin, P J AD - IIT Research Institute, Veterans Administration Lakeside Medical Center, Chicago, IL 60616. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 186 EP - 190 VL - 137 IS - 1 SN - 0003-0805, 0003-0805 KW - Antibodies KW - 0 KW - Phthalic Acids KW - Phthalic Anhydrides KW - trimellitic anhydride KW - 80T61EUU7H KW - Cyclophosphamide KW - 8N3DW7272P KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Lymphocyte Activation -- drug effects KW - Animals KW - Immunization, Passive KW - Lung -- drug effects KW - Lung -- pathology KW - Antibodies -- analysis KW - Male KW - Immunosuppression KW - Cyclophosphamide -- pharmacology KW - Phthalic Anhydrides -- toxicity KW - Lung Diseases -- chemically induced KW - Phthalic Anhydrides -- immunology KW - Lung Diseases -- pathology KW - Lung Diseases -- immunology KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78077422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Evidence+of+immunologic+control+of+lung+injury+induced+by+trimellitic+anhydride.&rft.au=Leach%2C+C+L%3BHatoum%2C+N+S%3BRatajczak%2C+H+V%3BZeiss%2C+C+R%3BGarvin%2C+P+J&rft.aulast=Leach&rft.aufirst=C&rft.date=1988-01-01&rft.volume=137&rft.issue=1&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Basal lamina of rat myocardium. Its fate after death of cardiac myocytes. AN - 78069872; 3336205 AB - As part of a study of the interactions between myocardial cells and extracellular matrix during healing of necrotic lesions, we have examined the fate of myocyte basal lamina (BL) after injury with ischemia, freeze-thawing, or isoproterenol. Using light and electron microscopy, and antibodies to three BL-associated antigens, we found that the BL of necrotic myocytes remained largely intact and continued to delineate the myocyte compartment from connective tissue space. Inflammatory cells entered the myocyte compartment through holes in the acellular BL and removed cell debris. The holes may have been produced by inflammatory cells and/or by the stretching force of the beating heart. After removal of debris, some BL sheaths of necrotic myocytes collapsed, resulting in spatial approximation of vessels. Interstitial cells deposited collagen and elastic fibers in the connective tissue space and within portions of the myocyte compartment. The acellular myocyte BL, collapsed or not, retained normal antigen staining for type IV collagen, laminin, and heparan sulfate for about 10 days, then showed diminished staining in patchy areas. These areas may correspond to BL disruption and degradation in conjunction with fibrosis, although a substantial amount of acellular BL remained in situ and became embedded in scar tissue. At least two types of granulo-vesicular bodies, measuring 25 to 60 and 60 to 160 nm respectively, were associated with the acellular BL; these were of unknown origin and function. The study shows that the fate of acellular BL in injured myocardium is similar to the fate of BL in other injured tissues; however, the appearance of holes in acellular BL, within hours after injury, is unusual and may enhance scar tissue formation. Whether the acellular BL contributes to regeneration of myocardium, as do acellular BLs in other injured tissues, remains to be determined. JF - Laboratory investigation; a journal of technical methods and pathology AU - Vracko, R AU - Cunningham, D AU - Frederickson, R G AU - Thorning, D AD - Laboratory Service, Veterans Administration Medical Center, Seattle, Washington. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 77 EP - 87 VL - 58 IS - 1 SN - 0023-6837, 0023-6837 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Cicatrix -- pathology KW - Animals KW - Necrosis KW - Coronary Disease -- pathology KW - Wound Healing KW - Coronary Disease -- chemically induced KW - Freezing KW - Isoproterenol -- toxicity KW - Basement Membrane -- ultrastructure KW - Basement Membrane -- pathology KW - Myocardium -- pathology KW - Myocardium -- ultrastructure KW - Cell Survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78069872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Basal+lamina+of+rat+myocardium.+Its+fate+after+death+of+cardiac+myocytes.&rft.au=Vracko%2C+R%3BCunningham%2C+D%3BFrederickson%2C+R+G%3BThorning%2C+D&rft.aulast=Vracko&rft.aufirst=R&rft.date=1988-01-01&rft.volume=58&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of cytochalasin B on the synthesis and secretion of plasma proteins by developing rat liver. AN - 78024473; 3335970 AB - Antimicrotubular drugs such as colchicine impair plasma protein secretion markedly less from developing liver than from mature tissue, suggesting the reduced participation of microtubules in hepatic protein secretion during liver development. In order to evaluate the possible contribution of microfilaments to protein export by immature liver, we incubated slices prepared from adult and gestation day 19 fetal rat liver for up to 4 h with the antimicrofilamentous agent cytochalasin B and with colchicine in various concentrations. In adult tissue, cytochalasin B did not reduce either the synthesis or secretion of [14C]leucine-labeled proteins and albumin. Cytochalasin B decreased apparent albumin synthesis by fetal liver, but otherwise, its effects on [14C]leucine incorporation did not differ from those observed in the adult. In contrast with leucine, the uptake of [3H]glucosamine into both adult and fetal liver was reduced by cytochalasin B. When this reduced uptake was normalized to that in corresponding control incubations, [3H]glucosamine incorporation into glycoproteins was markedly diminished in fetal slices, but was unaffected in the adult. Despite this age-dependent difference, cytochalasin B only minimally affected glycoprotein secretion in each group. Cytochalasin B never modified the antisecretory effects of colchicine. These results suggest that during early development, liver protein synthesis is more sensitive to toxic effects of cytochalasin B than during adulthood. However, microfilaments are not required for plasma protein export at either time. JF - Journal of pediatric gastroenterology and nutrition AU - Kaufman, S S AU - Tuma, D J AU - Park, J H AU - Grandjean, C J AD - Swanson Center for Nutrition, Inc., Veterans Administration Medical Center, Omaha, Nebraska. PY - 1988 SP - 107 EP - 114 VL - 7 IS - 1 SN - 0277-2116, 0277-2116 KW - Blood Proteins KW - 0 KW - Glycoproteins KW - Serum Albumin KW - Cytochalasin B KW - 3CHI920QS7 KW - Leucine KW - GMW67QNF9C KW - Glucosamine KW - N08U5BOQ1K KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Rats KW - Osmolar Concentration KW - Animals KW - Colchicine -- pharmacology KW - Glycoproteins -- biosynthesis KW - Leucine -- metabolism KW - In Vitro Techniques KW - Serum Albumin -- secretion KW - Glucosamine -- metabolism KW - Fetus -- metabolism KW - Male KW - Female KW - Blood Proteins -- biosynthesis KW - Cytochalasin B -- pharmacology KW - Liver -- secretion KW - Liver -- metabolism KW - Blood Proteins -- secretion KW - Liver -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78024473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+gastroenterology+and+nutrition&rft.atitle=Effects+of+cytochalasin+B+on+the+synthesis+and+secretion+of+plasma+proteins+by+developing+rat+liver.&rft.au=Kaufman%2C+S+S%3BTuma%2C+D+J%3BPark%2C+J+H%3BGrandjean%2C+C+J&rft.aulast=Kaufman&rft.aufirst=S&rft.date=1988-01-01&rft.volume=7&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+gastroenterology+and+nutrition&rft.issn=02772116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-16 N1 - Date created - 1988-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: synergy of antitumor activity with cis-diamminedichloroplatinum(II). AN - 78022214; 3334986 AB - 1-beta-D-Arabinofuranosylcytosine (ara-C) was tested at a concentration of 10 micrograms/ml in the human tumor colony-forming assay against 55 human tumors of various histological types. Using the criterion for sensitivity of at least 70% inhibition of colony formation, 12 tumors (22%) were sensitive to ara-C. ara-C was most active against lung tumors (3 of 8 tumors were sensitive), and melanomas (6 of 8 sensitive). However, ara-C was not active against breast cancer (0 of 7) or colon cancer (0 of 3), and only 1 of 13 ovarian cancers was sensitive to ara-C. The activity of ara-C against melanoma and other solid tumors was confirmed using a thymidine incorporation assay. The time (t) and concentration (C) dependency of the cytotoxicity of ara-C and other chemotherapeutic agents was determined. Most agents such as Adriamycin, cis-diamminedichloroplatinum(II) (cis-platinum), and bleomycin were found to follow the C x t rule. That is, as the drug concentration was doubled, an equivalent amount of cell kill was achieved in half the time. However, the activity of ara-C was more concentration dependent than time dependent. ara-C was more effective when cells were exposed to high concentrations for short time periods. Synergy of activity between ara-C and cis-platinum was demonstrated in the breast 231 and melanoma M19 cell lines. No synergy of interaction between these two drugs was observed in the colon HT29 and lung P3 cell lines. When fresh biopsy specimens were tested with the combination, there was evidence of a synergistic interaction in 9 of 36 (25%). Maximum cytotoxicity was obtained when cells were exposed to ara-C 2 h before the addition of cis-platinum. The addition of cis-platinum before ara-C decreased the synergism. JF - Cancer research AU - Kern, D H AU - Morgan, C R AU - Hildebrand-Zanki, S U AD - Research Service, Veterans Administration Medical Center, Sepulveda, California 91343. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 117 EP - 121 VL - 48 IS - 1 SN - 0008-5472, 0008-5472 KW - Cytarabine KW - 04079A1RDZ KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Cell Survival -- drug effects KW - Tumor Cells, Cultured -- drug effects KW - Dose-Response Relationship, Drug KW - Drug Synergism KW - Cytarabine -- pharmacology KW - Cisplatin -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Cytarabine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78022214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=In+vitro+pharmacodynamics+of+1-beta-D-arabinofuranosylcytosine%3A+synergy+of+antitumor+activity+with+cis-diamminedichloroplatinum%28II%29.&rft.au=Kern%2C+D+H%3BMorgan%2C+C+R%3BHildebrand-Zanki%2C+S+U&rft.aulast=Kern&rft.aufirst=D&rft.date=1988-01-01&rft.volume=48&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A new quantitative ultrasonic method for diagnosis of chronic parenchymal liver disease. AN - 78019695; 3275564 AB - The degree of echogenicity of the hepatic parenchyma was measured by an objective method comparing patient's sonograms with a tissue-mimicking phantom obtained with available real-time ultrasound machines. A single sonographic image of the liver and the phantom was taken using identical setting in each case. The ratio of the mean density of the phantom to that of the liver was obtained. The mean of the ratio in 30 normal subjects was 1.04 +/- 0.01, in 26 patients with early alcoholic liver disease 1.23 +/- 0.04, and in 74 cirrhotic subjects 1.54 +/- 0.03, with a significant difference among the three groups (p less than 0.05). A significant correlation was also obtained between the ratio and a modified Child's classification (r = 0.553, p less than 0.05) in cirrhotic subjects. Follow-up studies were available in a limited number of patients with early alcoholic liver disease showing progression or improvement paralleling alcohol use. Using this method, ultrasound may have considerable potential in the diagnosis and follow-up of alcoholic liver disease. JF - Gastroenterology AU - Medhat, A AU - Iber, F L AU - Dunne, M AD - Department of Medicine, Baltimore Veterans Administration Medical Center, Maryland. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 157 EP - 162 VL - 94 IS - 1 SN - 0016-5085, 0016-5085 KW - Abridged Index Medicus KW - Index Medicus KW - Models, Structural KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Female KW - Ultrasonography -- methods KW - Liver Diseases, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78019695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=A+new+quantitative+ultrasonic+method+for+diagnosis+of+chronic+parenchymal+liver+disease.&rft.au=Medhat%2C+A%3BIber%2C+F+L%3BDunne%2C+M&rft.aulast=Medhat&rft.aufirst=A&rft.date=1988-01-01&rft.volume=94&rft.issue=1&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-25 N1 - Date created - 1988-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characteristics of Female Adolescent Sexual Offenders AN - 61602114; 198800757 AB - A discussion of data describing F adolescent sexual offenders (N = 28) referred to the Juvenile Sexual Offender Program at the U of Washington, Seattle, for outpatient evaluation & treatment between 1978 & 1985. Unlike F adult sexual offenders of previous studies, these adolescents committed offenses without coercion from M co-offenders starting at an early age. Results are discussed with reference to gender differences among adolescent sexual offenders. 7 References. Modified HA JF - American Journal of Orthopsychiatry AU - Fehrenbach, Peter A AU - Monastersky, Caren AD - Family Therapy Program Veterans Administration Medical Center, 1660 South Columbian Way Seattle WA 98108 Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 148 EP - 151 VL - 58 IS - 1 SN - 0002-9432, 0002-9432 KW - female adolescent sexual offenders, sociodemographic characteristics KW - case records KW - Juvenile Sexual Offender Program, University of Washington, Seattle KW - 1978-1985 KW - Sex Differences KW - Seattle, Washington KW - Female Offenders KW - Sexual Abuse KW - Juvenile Offenders KW - Adolescents KW - Sociodemographic Factors KW - article KW - 6148: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61602114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Characteristics+of+Female+Adolescent+Sexual+Offenders&rft.au=Fehrenbach%2C+Peter+A%3BMonastersky%2C+Caren&rft.aulast=Fehrenbach&rft.aufirst=Peter&rft.date=1988-01-01&rft.volume=58&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Female Offenders; Sexual Abuse; Sociodemographic Factors; Seattle, Washington; Sex Differences; Adolescents; Juvenile Offenders ER - TY - JOUR T1 - A Comparative Study of the Attitudes of Alcoholic Veterans and Nonalcoholic Veterans toward Child Rearing Practices and Family Life AN - 61599776; 198801870 AB - A parental attitude questionnaire was administered to a stratified sample of 30 alcoholic veterans in a Veterans Administration alcohol treatment program & to 30 nonalcoholic M veterans employed at the same medical center in Biloxi, Miss. Analyses of variance reveal significant differences between the groups on 6 out of 20 scales; no significant differences regarding fatherhood, race, age, or SC are found. Results point to the need for intervention through teaching parental communication, interaction, & stress reduction skills to alcoholics to decrease the risk of their children becoming alcoholics. 3 Tables, 35 References. Modified HA JF - Journal of Drug Education AU - Pease, Barbara B AU - Hurlbert, David F AD - Veterans Administration Medical Center, Biloxi MS 39531 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 125 EP - 134 VL - 18 IS - 2 SN - 0047-2379, 0047-2379 KW - parenting attitudes/practices, alcoholic vs nonalcoholic males, intervention strategies KW - questionnaire KW - Veterans Administration alcohol treatment program participants/employees KW - Veterans KW - Males KW - Alcoholism KW - Mississippi KW - Childrearing Practices KW - article KW - 6144: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61599776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Drug+Education&rft.atitle=A+Comparative+Study+of+the+Attitudes+of+Alcoholic+Veterans+and+Nonalcoholic+Veterans+toward+Child+Rearing+Practices+and+Family+Life&rft.au=Pease%2C+Barbara+B%3BHurlbert%2C+David+F&rft.aulast=Pease&rft.aufirst=Barbara&rft.date=1988-01-01&rft.volume=18&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+Drug+Education&rft.issn=00472379&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Males; Alcoholism; Childrearing Practices; Veterans; Mississippi ER - TY - JOUR T1 - Ethical Considerations of Clinical Use of Miranda-Like Warnings AN - 61554637; 198901400 AB - Although psychotherapists are not generally required to provide Miranda-like warnings to their patients, many psychotherapists issue such warnings before encountering common clinical situations that have potential involvement with the legal system. These situations include involuntary hospitalization, the duty to warn & protect, & suspected child abuse reporting. One unethical motivation for use of such a warning would be to deliberately cause the patient to withhold information & therefore to avoid a confrontation. 32 References. Modified HA JF - Psychiatric Quarterly AU - Leong, Gregory B AU - Silva, J Arturo AU - Weinstock, Robert AD - Mental Health Clinic (B116A12) Veterans Administration Medical Center, 11301 Wilshire Blvd Los Angeles CA 90073 Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 293 EP - 305 VL - 59 IS - 4 SN - 0033-2720, 0033-2720 KW - psychotherapists, Miranda-like warning use, ethical considerations KW - Professional Ethics KW - Therapists KW - Psychotherapy KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61554637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=Ethical+Considerations+of+Clinical+Use+of+Miranda-Like+Warnings&rft.au=Leong%2C+Gregory+B%3BSilva%2C+J+Arturo%3BWeinstock%2C+Robert&rft.aulast=Leong&rft.aufirst=Gregory&rft.date=1988-01-01&rft.volume=59&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychotherapy; Therapists; Professional Ethics ER - TY - JOUR T1 - Processes of New Organizations: A Case Study AN - 61040162; 89U9649 AB - After briefly surveying the literature on new organizations, including external, internal, & longitudinal analyses of organizational emergence, an illustrative case study is presented of the creation & evolution of a state social service department. Using a political economy framework, analysis focuses on the multiple actors associated with the organization's founding, with emphasis on their diverse goals, the positioning process by which they assert their dominance, & how this activity is reflected in the organizational structure that emerges. Data from interviews (N not provided), a review of relevant documents, & observations of organizational functioning at area, regional, & central levels reveal consistent patterns of authority & interaction between the various actors involved. Ways that the historical study of organizations can contribute to a better understanding of organizations at later stages of their development are discussed. 25 References. K. Hyatt JF - Administration in Social Work AU - Marcus, Leonard J AD - Northeast Field Program Brockton/Roxbury Veterans Administration Medical Center, 1400 VFW Parkway MA 02401 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 91 EP - 106 VL - 12 IS - 3 SN - 0364-3107, 0364-3107 KW - state social service department, creation/evolution, authority/interaction patterns KW - interview/documentary/observational data KW - Government Agencies KW - Organizational Structure KW - Human Service Organizations KW - article KW - 0624: complex organization; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61040162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Social+Work&rft.atitle=Processes+of+New+Organizations%3A+A+Case+Study&rft.au=Marcus%2C+Leonard+J&rft.aulast=Marcus&rft.aufirst=Leonard&rft.date=1988-01-01&rft.volume=12&rft.issue=3&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Administration+in+Social+Work&rft.issn=03643107&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASWODB N1 - SubjectsTermNotLitGenreText - Human Service Organizations; Government Agencies; Organizational Structure ER - TY - JOUR T1 - Gender and the Expression of Schizophrenia AN - 61033070; 89U8685 AB - The expression of schizophrenia was examined in 169 diagnosed schizophrenics, about to be released from a private teaching psychiatric hospital in NY, using data from medical records & interviews conducted with patients & a member of their families. Findings indicated that schizophrenic women not only expressed more impulsivity & affective symptomatology than did men, but their psychotic symptoms covaried consistently with the expression of impulsivity, anger, & other affective symptomatology. Men's expression of schizophrenia covaried positively with withdrawal/isolation & an inability to function, suggesting a possible negative pattern. Gender differences were not attributable to misclassification, differences in diagnostic subtypes, nor selection. Results are discussed in light of their implications for understanding the heterogeneity of schizophrenia. 2 Tables, 1 Figure, 47 References. Modified HA JF - Journal of Psychiatric Research AU - Goldstein, Jill M AU - Link, Bruce G AD - Psychiatry Service Veterans Administration Medical Center, 940 Belmont St Brockton MA 02401 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 141 EP - 155 VL - 22 IS - 2 SN - 0022-3956, 0022-3956 KW - schizophrenia expression, gender differences KW - medical records, interviews KW - hospital patients, New York KW - Schizophrenia KW - New York KW - Verbal Communication KW - Sex Differences KW - Self Expression KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61033070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Gender+and+the+Expression+of+Schizophrenia&rft.au=Goldstein%2C+Jill+M%3BLink%2C+Bruce+G&rft.aulast=Goldstein&rft.aufirst=Jill&rft.date=1988-01-01&rft.volume=22&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Sex Differences; Self Expression; Verbal Communication; New York ER - TY - JOUR T1 - Pathological Gambling: A Parsimonious Need State Model AN - 61016236; 88U0831 AB - A parsimonious model of pathological gamblers is proposed that, while it recognizes the parallel importance of physiological phenomena, is based on two recurring psychological observations: gambling satisfies recurring & often intensified needs for the gambler; & pathological gamblers vary tremendously on several dimensions. The model suggests that attempts to understand pathological gambling must focus on subtypes of gamblers, two of which are discussed. 9 References. Modified HA JF - Journal of Gambling Behavior AU - McCormick, Richard A AD - Veterans Administration Medical Center, 10,000 Brecksville Rd Cleveland OH 44141 Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 257 EP - 263 VL - 3 IS - 4 SN - 0742-0714, 0742-0714 KW - pathological gambling, model proposed KW - Gambling KW - Diseases KW - Illness KW - Models KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61016236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gambling+Behavior&rft.atitle=Pathological+Gambling%3A+A+Parsimonious+Need+State+Model&rft.au=McCormick%2C+Richard+A&rft.aulast=McCormick&rft.aufirst=Richard&rft.date=1988-01-01&rft.volume=3&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gambling+Behavior&rft.issn=07420714&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGBEES N1 - SubjectsTermNotLitGenreText - Gambling; Models; Diseases; Illness ER - TY - JOUR T1 - Differences in Psychological Need Hierarchies between Black and White Drug Addicts AN - 60998936; 88T8698 AB - In a study of opiate & cocaine addicts in a Veterans Administration short-term, hospital-based treatment program for drug abuse, black addicts (N = 91) were compared to whites (N = 18) using the Adjective Checklist to assess psychological need hierarchies. Results indicate that white addicts had a significantly different pattern of needs, & evidenced more psychological dependence, distress, & maladjustment. These results are consistent with the MMPI literature showing white addicts to be more maladjusted than black addicts. 1 Table, 21 References. Modified HA JF - Journal of Clinical Psychology AU - Craig, Robert J AU - Olson, Ronald E AD - West Side Veterans Administration Medical Center, Chicago IL 60607 Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 82 EP - 86 VL - 44 IS - 1 SN - 0021-9762, 0021-9762 KW - psychological need hierarchies, black vs white opiate/cocaine addicts KW - checklists KW - Personality Traits KW - Black White Differences KW - Drug Addiction KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60998936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Differences+in+Psychological+Need+Hierarchies+between+Black+and+White+Drug+Addicts&rft.au=Craig%2C+Robert+J%3BOlson%2C+Ronald+E&rft.aulast=Craig&rft.aufirst=Robert&rft.date=1988-01-01&rft.volume=44&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Drug Addiction; Black White Differences; Personality Traits ER - TY - JOUR T1 - Distribution of Major Mental Disorders in a US Metropolis AN - 60988252; 89U8683 AB - A review of the evolution of psychiatric nosologies in North America & the major epidemiological surveys of mental disorders, culminating with the recently completed US National Instit of Mental Health Epidemiologic Catchment Area Project. The project aimed at estimating the prevalence & incidence of operationally defined disorders -- including alcohol, drug, phobic, dysthymic, & cognitive -- using DSM-III criteria, in large samples of community & institutional populations in five urban US communities: New Haven, Conn; Baltimore, Md; St. Louis, Mo; Durham, NC; & Los Angeles, Calif. Here, the data from Los Angeles are used to compare Hispanics & non-Hispanic whites. The Hispanic group shows greater overall prevalence of DSM-III disorders than whites. Mexico-born Mexican Americans reveal a lower prevalence for most disorders than US-born Mexican Americans. A subgroup of Mexican-American women aged 40+ demonstrates higher rates of phobic & dysthymic disorders & functional somatic symptoms than other groups. 4 Tables, 25 References. Modified HA JF - Acta Psychiatrica Scandinavica AU - Escobar, Javier I AU - Karno, Marvin AU - Burnam, Audrey AU - Hough, Richard L AU - Golding, Jacqueline AD - Veterans Administration Medical Center, 555 Willard Ave Newington CT 06111 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 45 EP - 53 VL - 78 KW - psychiatric disorders, prevalence/incidence, Hispanics vs non-Hispanic whites, Los Angeles, California KW - epidemiological study KW - Whites KW - Los Angeles, California KW - Cities KW - Hispanic Americans KW - Epidemiology KW - United States of America KW - Mental Illness KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60988252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Psychiatrica+Scandinavica&rft.atitle=Distribution+of+Major+Mental+Disorders+in+a+US+Metropolis&rft.au=Escobar%2C+Javier+I%3BKarno%2C+Marvin%3BBurnam%2C+Audrey%3BHough%2C+Richard+L%3BGolding%2C+Jacqueline&rft.aulast=Escobar&rft.aufirst=Javier&rft.date=1988-01-01&rft.volume=78&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Acta+Psychiatrica+Scandinavica&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - APYSA9 N1 - SubjectsTermNotLitGenreText - Cities; United States of America; Mental Illness; Epidemiology; Los Angeles, California; Whites; Hispanic Americans ER - TY - JOUR T1 - Factors Predisposing to Legionella Pneumophila Colonization in Residential Water Systems AN - 19021873; 8807941 AB - Fifty-five homes in the Pittsburgh area were surveyed for the presence of Legionella pneumophila colonization. Hot water tanks , faucets, and showerheads were sampled. Six homes yielded L. pneumophila within the water distribution system. Lower water temperatures (< 48.8 C) within the hot water system were significantly associated with the presence of L. pneumophila colonization. A similar association was found for electric heaters; however, this association may be an indirect one. Water temperatures in electrically heated tanks were significantly lower than in gas-heated tanks. City residents were also more likely to be colonized than suburban residences. Because acquisition of Legionnaire 's disease in the community has been linked to colonization of the water supplies in the homes of affected patients, these findings may have clinical implications for susceptible individuals residing in homes with water supplies colonized by L. pneumophila. (Author 's abstract) JF - Archives of Environmental Health AEHLAV Vol. 43, No. 1, p 59-62, January/February 1988. 1 tab, 10 ref. AU - Lee, T C AU - Stout, JE AU - Yu, V L AD - Veterans Administration Medical Center Pittsburgh, PA. Special Pathogens Section Y1 - 1988/01// PY - 1988 DA - Jan 1988 KW - Water Resources Abstracts KW - Microorganisms KW - Microbiological studies KW - Public health KW - Bacterial analysis KW - Impaired water quality KW - Domestic water KW - Potable water KW - Water management KW - Metropolitan water management KW - Temperature effects KW - Legionella pneumophila colonization KW - Residential water systems KW - Pennsylvania KW - Urban areas KW - Suburban areas KW - Legionnaire 's disease KW - SW 3060:Water treatment and distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19021873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Factors+Predisposing+to+Legionella+Pneumophila+Colonization+in+Residential+Water+Systems&rft.au=Lee%2C+T+C%3BStout%2C+JE%3BYu%2C+V+L&rft.aulast=Lee&rft.aufirst=T&rft.date=1988-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Characteristics of Female Adolescent Sexual Offenders AN - 1761724157; 198800757 AB - A discussion of data describing F adolescent sexual offenders (N = 28) referred to the Juvenile Sexual Offender Program at the U of Washington, Seattle, for outpatient evaluation & treatment between 1978 & 1985. Unlike F adult sexual offenders of previous studies, these adolescents committed offenses without coercion from M co-offenders starting at an early age. Results are discussed with reference to gender differences among adolescent sexual offenders. 7 References. Modified HA JF - American Journal of Orthopsychiatry AU - Fehrenbach, Peter A AU - Monastersky, Caren AD - Family Therapy Program Veterans Administration Medical Center, 1660 South Columbian Way Seattle WA 98108 Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 148 EP - 151 VL - 58 IS - 1 SN - 0002-9432, 0002-9432 KW - female adolescent sexual offenders, sociodemographic characteristics KW - case records KW - Juvenile Sexual Offender Program, University of Washington, Seattle KW - 1978-1985 KW - Sex Differences KW - Seattle, Washington KW - Female Offenders KW - Sexual Abuse KW - Juvenile Offenders KW - Adolescents KW - Sociodemographic Factors KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761724157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Characteristics+of+Female+Adolescent+Sexual+Offenders&rft.au=Fehrenbach%2C+Peter+A%3BMonastersky%2C+Caren&rft.aulast=Fehrenbach&rft.aufirst=Peter&rft.date=1988-01-01&rft.volume=58&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Female Offenders; Sexual Abuse; Sociodemographic Factors; Seattle, Washington; Sex Differences; Adolescents; Juvenile Offenders ER - TY - JOUR T1 - Environmental aspects of Legionnaire's disease AN - 13795135; 198803031 AB - Clinical symptoms of Legionnaire's disease are reviewed including the microbiology and diagnosis of the disease. Natural and man-made habitats included cooling towers, evaporative condensers and potable water systems. The mode of transmission of L. pneumophila by aerosol formation, aspiration and ingestion are described and methods of disinfection identified including hyperchlorination, thermal eradication, ozonation and UV irradiation. Evidence suggesting that potable water distribution systems were the primary source of Legionella organisms is presented. There are 72 references. JF - Journal of the American Water Resources Association AU - Muraca, P W AU - Yu, V L AU - Stout, JE AD - Veterans Administration Medical Center, Pittsburgh, Pa. Y1 - 1988 PY - 1988 DA - 1988 SP - 78 EP - 86 VL - 80 IS - 2 SN - 1093-474X, 1093-474X KW - Diseases (see also individual groups below) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13795135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Environmental+aspects+of+Legionnaire%27s+disease&rft.au=Muraca%2C+P+W%3BYu%2C+V+L%3BStout%2C+JE&rft.aulast=Muraca&rft.aufirst=P&rft.date=1988-01-01&rft.volume=80&rft.issue=2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Chronic ethanol consumption reduces [3H]inositol (1,4,5) trisphosphate specific binding in mouse cerebellar membrane fragments. AN - 77868667; 3501055 AB - [3H]In(1,4,5)P3 specific binding was determined in membrane fragments from various brain regions of adult male C57/BL mice. [3H]In(1,4,5)P3 specific binding was at least 10 times higher in cerebellum than in either striatum, cerebral cortex, hippocampus, or midbrain. Ethanol added in vitro up to 500 mM to cerebellar membrane fragments of control mice had no significant effect on [3H]In(1,4,5)P3 specific binding. In contrast, the maximal number of binding sites (Bmax) for [3H]In(1,4,5)P3 was significantly decreased in cerebella from mice which had been rendered tolerant-dependent to ethanol. KD values for these mice were unchanged when compared to control values. JF - Life sciences AU - Smith, T L AD - Research Service, Veterans Administration Medical Center, Tucson, AZ 85723. Y1 - 1987/12/28/ PY - 1987 DA - 1987 Dec 28 SP - 2863 EP - 2868 VL - 41 IS - 26 SN - 0024-3205, 0024-3205 KW - Inositol Phosphates KW - 0 KW - Sugar Phosphates KW - Ethanol KW - 3K9958V90M KW - Inositol 1,4,5-Trisphosphate KW - 85166-31-0 KW - Index Medicus KW - Animals KW - Ethanol -- pharmacology KW - Mice, Inbred C57BL KW - Membranes -- metabolism KW - Mice KW - Male KW - Binding Sites KW - Sugar Phosphates -- metabolism KW - Inositol Phosphates -- metabolism KW - Alcoholism -- metabolism KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77868667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Chronic+ethanol+consumption+reduces+%5B3H%5Dinositol+%281%2C4%2C5%29+trisphosphate+specific+binding+in+mouse+cerebellar+membrane+fragments.&rft.au=Smith%2C+T+L&rft.aulast=Smith&rft.aufirst=T&rft.date=1987-12-28&rft.volume=41&rft.issue=26&rft.spage=2863&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo. AN - 77868234; 2826946 AB - Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system. JF - Life sciences AU - Farese, R V AU - Fanjul, L F AU - de Ruiz Galarreta, C M AU - Davis, J S AU - Cooper, D R AD - Veterans Administration Hospital, Tampa, Florida. Y1 - 1987/12/14/ PY - 1987 DA - 1987 Dec 14 SP - 2631 EP - 2637 VL - 41 IS - 24 SN - 0024-3205, 0024-3205 KW - Diglycerides KW - 0 KW - Glycerides KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Animals KW - Cytosol -- enzymology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Protein Kinase C -- metabolism KW - Glycerides -- biosynthesis KW - Diglycerides -- biosynthesis KW - Adrenocorticotropic Hormone -- pharmacology KW - Adrenal Glands -- enzymology KW - Subcellular Fractions -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77868234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=ACTH+increases+diacylglycerol+content+and+subcellular+redistribution+of+protein+kinase+C+in+the+rat+adrenal+in+vivo.&rft.au=Farese%2C+R+V%3BFanjul%2C+L+F%3Bde+Ruiz+Galarreta%2C+C+M%3BDavis%2C+J+S%3BCooper%2C+D+R&rft.aulast=Farese&rft.aufirst=R&rft.date=1987-12-14&rft.volume=41&rft.issue=24&rft.spage=2631&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-25 N1 - Date created - 1988-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - [What relation exists between ethanol, atherosclerosis and high density lipoproteins]. TT - Quelle relation existe-t-il entre éthanol, athérosclérose et lipoprotéines de haute densité? AN - 77929881; 2963281 JF - Presse medicale (Paris, France : 1983) AU - Pignon, J P AU - Lieber, C S AD - Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1987/12/12/ PY - 1987 DA - 1987 Dec 12 SP - 2099 EP - 2100 VL - 16 IS - 42 SN - 0755-4982, 0755-4982 KW - Lipoproteins, HDL KW - 0 KW - Index Medicus KW - Humans KW - Lipoproteins, HDL -- blood KW - Arteriosclerosis -- blood KW - Arteriosclerosis -- etiology KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77929881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Presse+medicale+%28Paris%2C+France+%3A+1983%29&rft.atitle=%5BWhat+relation+exists+between+ethanol%2C+atherosclerosis+and+high+density+lipoproteins%5D.&rft.au=Pignon%2C+J+P%3BLieber%2C+C+S&rft.aulast=Pignon&rft.aufirst=J&rft.date=1987-12-12&rft.volume=16&rft.issue=42&rft.spage=2099&rft.isbn=&rft.btitle=&rft.title=Presse+medicale+%28Paris%2C+France+%3A+1983%29&rft.issn=07554982&rft_id=info:doi/ LA - fre DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-10 N1 - Date created - 1988-03-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Dependent and Independent Use of Microcomputers in Aphasia Rehabilitation AN - 85496376; 8804638 AB - Microcomputers can provide clinicians with improved methods for stimulus control, cue presentation, & data collection. Described are the modes of microcomputer treatment, the characteristics of the three modes of treatment (dependent, clinic-based independent, & home-based), & planning the treatment program (including hardware & software selection, patient selection, clinician responsibilities, & family support). A case study is presented. It is concluded that the microcomputer can be a valuable supplementary tool in lang therapy, & can be used both in the clinic & in the patient's home. 2 Tables, 36 References. J. Stidger JF - Topics in Language Disorders AU - Mills, Russell H AD - Audiology & Speech Pathology Service Veterans Administration Medical Center, 2215 Fuller Rd Ann Arbor MI 48105 Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 72 EP - 85 VL - 8 IS - 1 SN - 0271-8294, 0271-8294 KW - aphasia treatment KW - microcomputers role KW - Language Therapy (la7a) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85496376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Topics+in+Language+Disorders&rft.atitle=Dependent+and+Independent+Use+of+Microcomputers+in+Aphasia+Rehabilitation&rft.au=Mills%2C+Russell+H&rft.aulast=Mills&rft.aufirst=Russell&rft.date=1987-12-01&rft.volume=8&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Topics+in+Language+Disorders&rft.issn=02718294&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - TLDIDO N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Pathology (la4); Language Therapy (la7a) ER - TY - JOUR T1 - Language Treatment for Aphasia Is Efficacious, but for Whom? AN - 85331685; llba-8804642 AB - Group treatment trials, with a few exceptions, indicate lang treatment for aphasia is efficacious. However, these reports tell more about the disorder, aphasia, than they do about any individual who suffers it. The data to date indicate the best treatment candidates are those who have suffered a single, left hemisphere thromboembolic infarct; whose aphasia is moderately severe; who are three months or less postonet; & who receive at least three hours of treatment each week for at least five months. The efficacy of treatment for patients who do not meet these criteria remains to be determined. 16 References. AA JF - Topics in Language Disorders AU - Wertz, Robert T AD - Audiology & Speech Pathology Veterans Administration Center, 150 Muir Rd Martinez CA 94553 Y1 - 1987/12// PY - 1987 DA - Dec 1987 SP - 1 EP - 10 VL - 8 IS - 1 SN - 0271-8294, 0271-8294 KW - aphasia KW - language treatment effectiveness KW - *Language Therapy (la7a) KW - *Nervous System Pathology (ne3) KW - *Language Pathology (la4) KW - *Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85331685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Topics+in+Language+Disorders&rft.atitle=Language+Treatment+for+Aphasia+Is+Efficacious%2C+but+for+Whom%3F&rft.au=Wertz%2C+Robert+T&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=1987-12-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Topics+in+Language+Disorders&rft.issn=02718294&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - TLDIDO N1 - SubjectsTermNotLitGenreText - *Aphasia (ap1); *Language Pathology (la4); *Nervous System Pathology (ne3); *Language Therapy (la7a) ER - TY - JOUR T1 - Surgery to quieten the yelling of a demented old man. AN - 85265217; pmid-3694639 AB - The 84-year-old man's incessant yelling caused him to be unmanageable in all settings--at home with his aged wife, in nursing homes, and on the medical and psychiatric floors of a Veterans Administration Medical Center. A host of behavioural and pharmaceutical interventions were attempted unsuccessfully. Finally, it was proposed that a single, recurrent laryngeal nerve be crushed in order to 'render his voice to be a very acceptable soft tone'. JF - Journal of Medical Ethics AU - Gafner, G AD - Veterans Administration Medical Center, Tucson, Arizona. PY - 1987 SP - 195 EP - 197 VL - 13 IS - 4 SN - 0306-6800, 0306-6800 KW - Laryngeal Nerves KW - Nonverbal Communication KW - Beneficence KW - Human KW - Aged KW - Case Report KW - Dementia KW - Male KW - Risk Assessment KW - Behavior Control KW - Ethics, Medical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85265217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Ethics&rft.atitle=Surgery+to+quieten+the+yelling+of+a+demented+old+man.&rft.au=Gafner%2C+G&rft.aulast=Gafner&rft.aufirst=G&rft.date=1987-12-01&rft.volume=13&rft.issue=4&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Ethics&rft.issn=03066800&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The effect of 15(R)-15-methyl prostaglandin E2 (Arbacet) on the healing of aspirin or nonsteroidal antiinflammatory drug-induced gastric mucosal lesions: an endoscopic study. AN - 85219934; pmid-3318402 AB - Twenty-nine outpatients chronically ingesting daily aspirin or nonsteroidal antiinflammatory drugs for rheumatological disease, who had endoscopically proven gastric mucosal lesions worse than erythema, were evaluated for 4 wk in a randomized, double-blind trial comparing 15(R)-15-methyl prostaglandin E2 (Arbacet) (10 micrograms, 0.5 h before each meal and at bedtime) with placebo. Patients continued their usual daily dose of antiarthritic medication throughout the study period, and an endoscopy was performed on the final day to assess healing. Five of 14 patients (36%) taking Arbacet and two of 15 patients (13%) in the placebo group had complete healing of their gastric lesions after 4 wk. Arbacet at a daily dose of 40 micrograms is not significantly better than placebo in healing gastric lesions caused by aspirin or nonsteroidal antiinflammatory drugs, if antiinflammatory therapy is continued. JF - The American Journal of Gastroenterology AU - Jaszewski, R AU - Crane, S A AD - Department of Gastroenterology, Veterans Administration Medical Center/Wayne State University Affiliated Hospitals, Allen Park, Michigan. PY - 1987 SP - 1271 EP - 1274 VL - 82 IS - 12 SN - 0002-9270, 0002-9270 KW - Gastroscopy KW - Double-Blind Method KW - Random Allocation KW - Wound Healing KW - Human KW - Clinical Trials KW - Prostaglandins E, Synthetic KW - Prospective Studies KW - Comparative Study KW - Aspirin KW - Gastric Mucosa KW - Middle Age KW - Support, Non-U.S. Gov't KW - Arbaprostil KW - Anti-Inflammatory Agents, Non-Steroidal KW - Gastritis KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85219934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=The+effect+of+15%28R%29-15-methyl+prostaglandin+E2+%28Arbacet%29+on+the+healing+of+aspirin+or+nonsteroidal+antiinflammatory+drug-induced+gastric+mucosal+lesions%3A+an+endoscopic+study.&rft.au=Jaszewski%2C+R%3BCrane%2C+S+A&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1987-12-01&rft.volume=82&rft.issue=12&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Gastrointestinal involvement in insulin-requiring diabetes mellitus. AN - 85213597; pmid-3443733 AB - Gastrointestinal (GI) dysfunction in diabetes mellitus has never been evaluated systematically in all parts of the digestive system in a group of diabetics. Therefore, we have evaluated the frequency, extent, and clinical significance of GI complications in 75 consecutive, male, insulin-requiring diabetics (46 with neuropathy). Nineteen percent of the 75 patients and 30% of those with neuropathy had one or more GI symptoms. Esophageal, gastric, gallbladder, and small intestinal functions were studied in 30 patients using radionuclide esophageal and gastric emptying, postprandial gallbladder emptying, and intestinal transit of lactulose. We divided them into three groups: (1) 10 without neuropathy, (2) 10 with peripheral neuropathy, and (3) 10 with autonomic and peripheral neuropathy. Twenty-five patients (83%) had abnormalities of at least one GI organ, and 57% had abnormalities of two. Nineteen of the 25 patients (76%) with GI involvement and 8 of 9 (89%) symptomatic diabetics had delayed esophageal emptying. Symptomatic diabetics had more diabetic retinopathy, neuropathy, and autonomic dysfunction than asymptomatic diabetics and also had more widespread and more severe gastrointestinal involvement than asymptomatic diabetics. Therefore, our results indicate that in diabetics, (1) gastrointestinal motor abnormalities are common even though they are usually asymptomatic and (2) gastrointestinal dysfunction, especially in symptomatic diabetics, is often widespread and usually includes the esophagus. JF - Journal of Clinical Gastroenterology AU - Keshavarzian, A AU - Iber, F L AD - Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland. PY - 1987 SP - 685 EP - 692 VL - 9 IS - 6 SN - 0192-0790, 0192-0790 KW - Esophagus KW - Gallbladder KW - Gastric Emptying KW - Diabetic Neuropathies KW - Human KW - Diabetes Mellitus, Insulin-Dependent KW - Intestine, Small KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Gastrointestinal Transit KW - Male KW - Stomach UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Gastrointestinal+involvement+in+insulin-requiring+diabetes+mellitus.&rft.au=Keshavarzian%2C+A%3BIber%2C+F+L&rft.aulast=Keshavarzian&rft.aufirst=A&rft.date=1987-12-01&rft.volume=9&rft.issue=6&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Hodgkin's disease presenting as diffuse nonspecific inflammation of small bowel. AN - 85208512; pmid-3443735 AB - I report an unusual case of primary retroperitoneal Hodgkin's disease. The initial presentation radiographically involved diffuse thickening of small bowel folds from the duodenum through the terminal ileum. The histologic picture consisted of diffuse, nonspecific inflammation with an infiltrate resembling that seen in tropical sprue. The clinical picture consisted of progressive diffuse abdominal pain, fever, diarrhea, and weight loss. The histologic and radiographic abnormalities returned to normal with chemotherapy. Computerized search of the English language literature uncovered no similar case presentation. JF - Journal of Clinical Gastroenterology AU - Manning, R J AD - Veterans Administration Medical Center, Fayetteville, AR 72701. PY - 1987 SP - 701 EP - 704 VL - 9 IS - 6 SN - 0192-0790, 0192-0790 KW - Enteritis KW - Human KW - Adult KW - Biopsy KW - Case Report KW - Hodgkin Disease KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Hodgkin%27s+disease+presenting+as+diffuse+nonspecific+inflammation+of+small+bowel.&rft.au=Manning%2C+R+J&rft.aulast=Manning&rft.aufirst=R&rft.date=1987-12-01&rft.volume=9&rft.issue=6&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A computerized data management system for head and neck oncology. AN - 85186015; pmid-3683055 AB - Medical information, diagnostic technology, and modes of therapeutic intervention available for treatment of head and neck cancer have increased exponentially. The concurrent explosion of microcomputer technology has created an ideal instrument for organizing, storing, and reporting the expanded data the head and neck oncologist must now consider. This paper presents the principles, design, and operation of a recently developed head and neck oncological database program (HNODB). Details of implementation on a microcomputer are also described. A historical review of currently used prominent cancer registration programs is presented. It defines the fundamental elements of cancer registration. A review of cancer registration in the United States shows that current systems have various deficiencies and have not kept pace with the evolution of diagnostics, treatments, and computer technologies. The HNODB database program, however, is a valuable model for cancer data management, for it can be applied to small or extensive data collection needs, and it provides an accurate system to identify risk factors, numbers of patients treated and types of treatment given. The program allows for rapid analysis of treatment, results, follow-up, and survival rates of patients with carcinoma of the head and neck. JF - The Laryngoscope AU - Fletcher, M M AU - McManus, C D AD - Veterans Administration Medical Center, Washington, DC. PY - 1987 SP - 1422 EP - 1429 VL - 97 IS - 12 SN - 0023-852X, 0023-852X KW - Demography KW - Medical Records KW - Comparative Study KW - Neoplasm Staging KW - Head and Neck Neoplasms KW - Human KW - Risk Factors KW - Follow-Up Studies KW - Medical Oncology KW - Software KW - Database Management Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85186015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=A+computerized+data+management+system+for+head+and+neck+oncology.&rft.au=Fletcher%2C+M+M%3BMcManus%2C+C+D&rft.aulast=Fletcher&rft.aufirst=M&rft.date=1987-12-01&rft.volume=97&rft.issue=12&rft.spage=1422&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of ibuprofen on the hypoxemia of established ethchlorvynol-induced unilateral acute lung injury in anesthetized dogs. AN - 81113944; 3677816 AB - Nonsteroidal anti-inflammatory agents, given prior to induction of unilateral acute lung injury with ethchlorvynol (ECV) in anesthetized dogs, prevent the decreases in systemic oxygen tension (PaO2) which are observed when ECV is given alone. We investigated whether ibuprofen, administered after acute lung injury, would result in improvement in arterial oxygenation. In animals not receiving ibuprofen after unilateral acute lung injury with ECV, PaO2 decreased and venous admixture increased significantly from control values at all experimental time-periods. In those animals receiving ibuprofen, significant decreases in venous admixture were noted. The decrease in PaO2 after ECV administration was significantly less than that observed in animals that did not receive ibuprofen after acute lung injury (p less than 0.05). Ibuprofen had no effect on extravascular lung water. These results demonstrate that in an ECV model of acute lung injury the administration of ibuprofen, after the acute lung injury, results in significant decreases in venous admixture. JF - Chest AU - Sprague, R S AU - Stephenson, A H AU - Dahms, T E AU - Asner, N G AU - Lonigro, A J AD - Medical Service, Veterans Administration Medical Center, St. Louis. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1088 EP - 1093 VL - 92 IS - 6 SN - 0012-3692, 0012-3692 KW - Ethchlorvynol KW - 6EIM3851UZ KW - Ibuprofen KW - WK2XYI10QM KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Dogs KW - Male KW - Lung Diseases -- drug therapy KW - Ethchlorvynol -- toxicity KW - Lung Diseases -- chemically induced KW - Ibuprofen -- therapeutic use KW - Hypoxia -- drug therapy KW - Hypoxia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81113944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Effects+of+ibuprofen+on+the+hypoxemia+of+established+ethchlorvynol-induced+unilateral+acute+lung+injury+in+anesthetized+dogs.&rft.au=Sprague%2C+R+S%3BStephenson%2C+A+H%3BDahms%2C+T+E%3BAsner%2C+N+G%3BLonigro%2C+A+J&rft.aulast=Sprague&rft.aufirst=R&rft.date=1987-12-01&rft.volume=92&rft.issue=6&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-13 N1 - Date created - 1988-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency. AN - 81104978; 2445461 AB - A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency. JF - Cancer AU - McLeod, B F AU - Lawrence, H J AU - Smith, D W AU - Vogt, P J AU - Gandara, D R AD - Department of Medicine, Veterans Administration Medical Center, Martinez, California 94553. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 2617 EP - 2620 VL - 60 IS - 11 SN - 0008-543X, 0008-543X KW - Bleomycin KW - 11056-06-7 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Humans KW - Middle Aged KW - Male KW - Kidney Failure, Chronic -- metabolism KW - Bleomycin -- administration & dosage KW - Bleomycin -- metabolism KW - Lung -- drug effects KW - Lung -- pathology KW - Kidney Failure, Chronic -- complications KW - Bleomycin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81104978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Fatal+bleomycin+toxicity+from+a+low+cumulative+dose+in+a+patient+with+renal+insufficiency.&rft.au=McLeod%2C+B+F%3BLawrence%2C+H+J%3BSmith%2C+D+W%3BVogt%2C+P+J%3BGandara%2C+D+R&rft.aulast=McLeod&rft.aufirst=B&rft.date=1987-12-01&rft.volume=60&rft.issue=11&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-21 N1 - Date created - 1987-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sleep disturbances in various nonaffective psychiatric disorders. AN - 78043321; 2902603 AB - This article reviews electroencephalographic sleep studies in schizophrenia, obsessive-compulsive disorder, eating disorders, panic disorder, borderline personality disorder, Alzheimer's disease, and certain instances of substance abuse. JF - The Psychiatric clinics of North America AU - Gierz, M AU - Campbell, S S AU - Gillin, J C AD - Department of Psychiatry, Veterans Administration Medical Center, San Diego, California. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 565 EP - 581 VL - 10 IS - 4 SN - 0193-953X, 0193-953X KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Substance Withdrawal Syndrome -- physiopathology KW - Humans KW - Alzheimer Disease -- physiopathology KW - Central Nervous System Stimulants -- adverse effects KW - Schizophrenia -- physiopathology KW - Anxiety Disorders -- physiopathology KW - Sleep -- physiology KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78043321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Sleep+disturbances+in+various+nonaffective+psychiatric+disorders.&rft.au=Gierz%2C+M%3BCampbell%2C+S+S%3BGillin%2C+J+C&rft.aulast=Gierz&rft.aufirst=M&rft.date=1987-12-01&rft.volume=10&rft.issue=4&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-22 N1 - Date created - 1988-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model. AN - 77986406; 2832432 AB - Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives. We studied a murine hepatitis model of HSV infection to determine whether this in vitro observation would also be demonstrable in vivo. Following i.v. injection of 100 or 160 mg/kg TFT, TFT was found in significantly higher concentrations in the livers of HSV-2 infected mice than in the livers of uninfected mice, mice infected with murine hepatitis virus (MHV-A59) or mice with hepatitis from carbon tetrachloride treatment. Neither altered renal function, nor altered pharmacokinetics could account for this difference. 19F Nuclear Magnetic Resonance spectroscopy readily detected the 19F from TFT in both liver extracts and whole livers, particularly at higher tissue levels, i.e. greater than 50 micrograms/g tissue. If further studies with living animals support these preliminary observations, clinical application could be pursued. JF - Journal of virological methods AU - Rand, K H AU - Raad, I AU - el Koussi, A AU - Houck, H J AU - Brey, W AU - Rocca, J AU - Loftsson, T AU - Bodor, N AD - Department of Pathology, Gainesville Veterans Administration Medical Center, Florida. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 257 EP - 269 VL - 18 IS - 4 SN - 0166-0934, 0166-0934 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Trifluridine KW - RMW9V5RW38 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Animals KW - Simplexvirus -- analysis KW - Mice, Inbred CBA KW - Murine hepatitis virus -- metabolism KW - Mice KW - Carbon Tetrachloride -- toxicity KW - Liver -- analysis KW - Magnetic Resonance Spectroscopy KW - Chemical and Drug Induced Liver Injury -- microbiology KW - Herpes Simplex -- diagnosis KW - Trifluridine -- analysis KW - Hepatitis, Viral, Animal -- metabolism KW - Thymidine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77986406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virological+methods&rft.atitle=Trifluorothymidine%3A+potential+non-invasive+diagnosis+of+herpes+simplex+infection+using+19F+nuclear+magnetic+resonance+in+a+murine+hepatitis+model.&rft.au=Rand%2C+K+H%3BRaad%2C+I%3Bel+Koussi%2C+A%3BHouck%2C+H+J%3BBrey%2C+W%3BRocca%2C+J%3BLoftsson%2C+T%3BBodor%2C+N&rft.aulast=Rand&rft.aufirst=K&rft.date=1987-12-01&rft.volume=18&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+virological+methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-22 N1 - Date created - 1988-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Depression among alcoholics. AN - 77935116; 3436691 AB - The relationships of cognition, health status, and age to depression among alcoholics were studied. Eighty male alcoholics in an alcohol treatment unit were rated on health status and given a battery of psychological tests and scales. These included the Hooper VOT (cognition) and several self-rated depression indices: MMPI-Depression, MCMI-Dysthymic, BDI-Total (BDI-Somatic and BDI-Psychological), and the Geriatric Depression Scale (GDS). Results showed that depression was present in this sample at mild clinical levels. Regression analyses showed that age was the most influential factor on the MMPI-D and BDI-Somatic. Age also was most influential on the GDS, with health status contributing. However, except for somatic depression, the amount of explained variance was small. Despite this, it is argued that age is a contributing factor to depression among alcoholics, especially the somatic elements of depression. JF - The International journal of the addictions AU - Hyer, L AU - Carson, M AU - Nixon, D AU - Tamkin, A AU - Saucer, R T AD - Psychology Service, Veterans Administration Medical Center, Augusta, Georgia 30910. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1235 EP - 1241 VL - 22 IS - 12 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Age Factors KW - Humans KW - Health Status KW - Adult KW - Middle Aged KW - Male KW - Cognition KW - Depression -- psychology KW - Depression -- complications KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77935116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Depression+among+alcoholics.&rft.au=Hyer%2C+L%3BCarson%2C+M%3BNixon%2C+D%3BTamkin%2C+A%3BSaucer%2C+R+T&rft.aulast=Hyer&rft.aufirst=L&rft.date=1987-12-01&rft.volume=22&rft.issue=12&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metacarpophalangeal arthropathy associated with manual labor (Missouri metacarpal syndrome). Clinical radiographic, and pathologic characteristics of an unusual degeneration process. AN - 77933856; 3435567 AB - We describe 7 manual laborers with painful, palpably enlarged metacarpophalangeal joints. Characteristic radiographic changes were joint space loss, prominent osteophytes, and cystic metacarpal heads most prominent in the second and third metacarpophalangeal joints. In 3 of 4 patients, joint biopsy specimens showed subsynovial fibrosis and villous hyperplasia. All 7 patients had similar backgrounds of heavy work demanding sustained gripping motions of both hands, for periods that exceeded 30 years. We designated their condition metacarpophalangeal arthropathy associated with manual labor. JF - Arthritis and rheumatism AU - Williams, W V AU - Cope, R AU - Gaunt, W D AU - Adelstein, E H AU - Hoyt, T S AU - Singh, A AU - Pressly, T A AU - English, R AU - Schumacher, H R AU - Walker, S E AD - Veterans Administration Medical Center, Columbia, Missouri. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1362 EP - 1371 VL - 30 IS - 12 SN - 0004-3591, 0004-3591 KW - Abridged Index Medicus KW - Index Medicus KW - Joint Diseases -- pathology KW - Joint Diseases -- diagnosis KW - Joint Diseases -- diagnostic imaging KW - Syndrome KW - Humans KW - Aged KW - Middle Aged KW - Biopsy KW - Radiography KW - Occupations KW - Male KW - Synovial Membrane -- pathology KW - Occupational Diseases -- diagnosis KW - Occupational Diseases -- diagnostic imaging KW - Cumulative Trauma Disorders -- diagnosis KW - Finger Joint -- diagnostic imaging KW - Cumulative Trauma Disorders -- diagnostic imaging KW - Metacarpophalangeal Joint -- diagnostic imaging KW - Finger Joint -- pathology KW - Metacarpophalangeal Joint -- pathology KW - Occupational Diseases -- pathology KW - Cumulative Trauma Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77933856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Metacarpophalangeal+arthropathy+associated+with+manual+labor+%28Missouri+metacarpal+syndrome%29.+Clinical+radiographic%2C+and+pathologic+characteristics+of+an+unusual+degeneration+process.&rft.au=Williams%2C+W+V%3BCope%2C+R%3BGaunt%2C+W+D%3BAdelstein%2C+E+H%3BHoyt%2C+T+S%3BSingh%2C+A%3BPressly%2C+T+A%3BEnglish%2C+R%3BSchumacher%2C+H+R%3BWalker%2C+S+E&rft.aulast=Williams&rft.aufirst=W&rft.date=1987-12-01&rft.volume=30&rft.issue=12&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-16 N1 - Date created - 1988-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute alcohol intoxication: sex comparisons on pharmacokinetic and mood measures. AN - 77930856; 3324798 AB - This study explored sex differences in pharmacokinetic and mood state responses to acute alcohol intoxication among socially drinking women demonstrated to be normally cycling across two consecutive menstrual cycles and men with similar drinking habits. Subjects were administered moderate or high alcohol doses in six experimental sessions over a 60-day period. Women were tested during the early follicular, ovulatory, and midluteal phases of the cycle, and men were administered alcohol at comparable time intervals. Results showed that men did not differ in alcohol pharmacokinetics across sessions, but women showed significantly shorter elimination times and faster disappearance rates during the midluteal phase of the menstrual cycle compared to the early follicular and ovulatory phases and to their male counterparts. There were no sex or within-group differences in self-reported negative mood states prior to alcohol administration, but women described increased anxiety and depression while intoxicated during the early follicular compared to ovulatory and midluteal phases. Affective responses to intoxication were a complex function of sex, limb of the blood alcohol concentration-time curve, and dose. JF - Alcoholism, clinical and experimental research AU - Sutker, P B AU - Goist, K C AU - Allain, A N AU - Bugg, F AD - Psychology Service, Veterans Administration Medical Center, New Orleans, Louisiana 70146. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 507 EP - 512 VL - 11 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Ethanol -- blood KW - Ethanol -- pharmacokinetics KW - Affect -- drug effects KW - Sex Characteristics KW - Menstrual Cycle KW - Alcoholic Intoxication -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77930856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Acute+alcohol+intoxication%3A+sex+comparisons+on+pharmacokinetic+and+mood+measures.&rft.au=Sutker%2C+P+B%3BGoist%2C+K+C%3BAllain%2C+A+N%3BBugg%2C+F&rft.aulast=Sutker&rft.aufirst=P&rft.date=1987-12-01&rft.volume=11&rft.issue=6&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-09 N1 - Date created - 1988-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics. AN - 77929647; 3324809 AB - Following an acute dose of alcohol (0.15 g/kg intravenously), blood levels of acetaldehyde were significantly higher in nonabstinent alcoholics than in controls. After 2 weeks of abstinence, this blood acetaldehyde response significantly decreased in alcoholics and the acetaldehyde returned towards levels comparable to those observed in nonalcoholics. These results suggest that elevated blood acetaldehyde levels in the alcoholics are secondary to the chronic alcohol consumption rather than reflecting a primary preexisting defect. JF - Alcoholism, clinical and experimental research AU - Di Padova, C AU - Worner, T M AU - Lieber, C S AD - Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, New York 10468. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 559 EP - 561 VL - 11 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Humans KW - Adult KW - Temperance KW - Male KW - Acetaldehyde -- blood KW - Ethanol -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77929647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effect+of+abstinence+on+the+blood+acetaldehyde+response+to+a+test+dose+of+alcohol+in+alcoholics.&rft.au=Di+Padova%2C+C%3BWorner%2C+T+M%3BLieber%2C+C+S&rft.aulast=Di+Padova&rft.aufirst=C&rft.date=1987-12-01&rft.volume=11&rft.issue=6&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-09 N1 - Date created - 1988-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acquisition of peroxidase activity by rat alveolar macrophages during pulmonary inflammation. AN - 77921720; 2827491 AB - The authors investigated the ability of rat alveolar macrophages to acquire peroxidase activity in the course of pulmonary inflammation. Granulomatous pulmonary inflammation was induced in bacille Calmette-Guérin (BCG)-immunized rats by intravenous injection of BCG in mineral oil. In contrast to normal alveolar macrophages, which are peroxidase-negative, alveolar macrophages lavaged from the BCG-treated rats showed significant peroxidase activity in large cytoplasmic inclusions compatible with internalized exogenous material. Alveolar macrophage uptake of intact peroxidase-positive neutrophils was also observed. Maximal numbers of peroxidase-positive alveolar macrophages were observed after the initial influx of neutrophils into the lungs, and peroxidase activity could be demonstrated in cell-free lavage fluid during the acute phase of lung injury. Normal alveolar macrophages acquired peroxidase activity after incubation with peritoneal exudate neutrophils, with purified soluble human myeloperoxidase, and with opsonized erythrocytes. It is concluded that alveolar macrophages acquire peroxidase activity from multiple sources during pulmonary inflammation. Internalization of peroxidase by the alveolar macrophage may serve to clear a potentially toxic enzyme(s) from the alveolar space and contribute to the resolution of pulmonary inflammation. JF - The American journal of pathology AU - Shellito, J AU - Sniezek, M AU - Warnock, M AD - Respiratory Care Section, Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 567 EP - 577 VL - 129 IS - 3 SN - 0002-9440, 0002-9440 KW - Hemoglobins KW - 0 KW - Peroxidase KW - EC 1.11.1.7 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Hemoglobins -- metabolism KW - Cells, Cultured KW - Humans KW - Mycobacterium bovis -- immunology KW - Male KW - Immunization KW - Macrophages -- enzymology KW - Pneumonia -- immunology KW - Pulmonary Alveoli -- metabolism KW - Peroxidase -- pharmacology KW - Pneumonia -- enzymology KW - Pulmonary Alveoli -- enzymology KW - Peroxidase -- metabolism KW - Pulmonary Alveoli -- cytology KW - Macrophages -- ultrastructure KW - Pneumonia -- pathology KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77921720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Acquisition+of+peroxidase+activity+by+rat+alveolar+macrophages+during+pulmonary+inflammation.&rft.au=Shellito%2C+J%3BSniezek%2C+M%3BWarnock%2C+M&rft.aulast=Shellito&rft.aufirst=J&rft.date=1987-12-01&rft.volume=129&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-25 N1 - Date created - 1988-01-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Histochem Cytochem. 1966 Apr;14(4):291-302 [5962951] J Biol Chem. 1958 Jul;233(1):209-11 [13563471] J Exp Med. 1971 Oct 1;134(4):907-34 [4106490] J Cell Biol. 1971 Aug;50(2):498-515 [4107019] J Reticuloendothel Soc. 1971 Aug;10(2):163-72 [4107662] J Exp Med. 1973 Jul 1;138(1):318-23 [4717124] Blood. 1975 May;45(5):699-707 [1173052] Histochemistry. 1975;41(4):281-312 [237853] Lab Invest. 1976 Jan;34(1):31-42 [1246123] N Engl J Med. 1978 Mar 23;298(12):659-68 [24176] J Reticuloendothel Soc. 1978 May;23(5):343-59 [671421] J Clin Invest. 1979 Sep;64(3):824-33 [89120] J Clin Invest. 1979 Oct;64(4):913-20 [225353] J Immunol. 1980 Mar;124(3):1378-82 [6987309] J Immunol. 1980 Apr;124(4):1949-53 [7365245] J Clin Invest. 1980 Aug;66(2):167-75 [6249846] J Reticuloendothel Soc. 1980 Oct;28(4):391-404 [7431371] J Biol Chem. 1981 Apr 10;256(7):3348-53 [6162845] J Immunol. 1982 Jan;128(1):415-20 [7054281] J Clin Invest. 1982 Feb;69(2):255-62 [6276438] J Biol Chem. 1982 Mar 25;257(6):2738-40 [6277912] J Exp Med. 1982 Aug 1;156(2):430-42 [7097159] Blood. 1982 Sep;60(3):618-22 [6286012] Am Rev Respir Dis. 1983 May;127(5):631-5 [6342481] Eur J Cell Biol. 1983 Mar;30(1):112-25 [6682762] Cell Immunol. 1983 Dec;82(2):246-57 [6360381] J Biol Chem. 1983 Dec 25;258(24):15004-10 [6317683] J Cell Biol. 1984 Feb;98(2):748-60 [6229546] Am Rev Respir Dis. 1984 May;129(5):747-53 [6609653] Blood. 1985 Feb;65(2):484-91 [2981591] J Submicrosc Cytol. 1985 Apr;17(2):141-51 [3999179] Am Rev Respir Dis. 1986 Feb;133(2):218-25 [3004270] J Exp Med. 1970 Oct 1;132(4):794-812 [5508378] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human platelet factor 4 and protamine sulphate interaction with glycosaminoglycans in the rabbit. AN - 77917289; 3123254 AB - We studied the action of protamine sulphate on human platelet factor 4 (PF4) kinetics in rabbits in the presence of various glycosaminoglycans (CAGs). The animals pretreated with heparin showed high initial PF4 levels with a subsequent slow monoexponential clearance. The PF4 kinetics, in the presence of heparan and dermatan sulphate, reflected the different affinities that PF4 has for these GAGs. Protamine, at dosages that totally neutralized 1000 USP units of heparin pretreatment, caused an immediate disappearance in the circulating PF4. However, a second heparin injection 10 min after protamine, induced a PF4 peak release. It is possible that protamine displaced the PF4 from the binding sites of heparin, releasing it for storage in the body 'pool', from where it can be harvested again. The action of protamine on PF4 kinetics in the rabbits pretreated with 30 mg heparan sulphate was similar to that obtained with heparin pretreatment; however, a higher dose of protamine was required to obtain the optimal effect. After a 20 mg dose of protamine, unexpectedly, a bolus of heparin did not produce any peak release of PF4 in the rabbits pretreated with 30 mg of dermatan sulphate. Although part of the protamine will displace PF4 from the binding sites of the dermatan sulphate molecule, the remaining part of protamine could probably be bound to this GAG without losing its activity so that, upon subsequent heparin injection, it is immediately neutralized, rendering it unavailable for further PF4 harvesting. JF - European journal of clinical investigation AU - Cella, G AU - Myers, C J AU - Prosdocimi, M AU - Sasahara, A A AD - Brockton-West Roxbury Veterans Administration Medical Center, Massachusetts. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 548 EP - 554 VL - 17 IS - 6 SN - 0014-2972, 0014-2972 KW - Glycosaminoglycans KW - 0 KW - Protamines KW - Dermatan Sulfate KW - 24967-94-0 KW - Platelet Factor 4 KW - 37270-94-3 KW - Heparin KW - 9005-49-6 KW - Heparitin Sulfate KW - 9050-30-0 KW - Index Medicus KW - Dermatan Sulfate -- pharmacology KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Heparin -- pharmacology KW - Heparitin Sulfate -- pharmacology KW - Rabbits KW - Male KW - Glycosaminoglycans -- pharmacology KW - Protamines -- pharmacology KW - Platelet Factor 4 -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77917289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+investigation&rft.atitle=Human+platelet+factor+4+and+protamine+sulphate+interaction+with+glycosaminoglycans+in+the+rabbit.&rft.au=Cella%2C+G%3BMyers%2C+C+J%3BProsdocimi%2C+M%3BSasahara%2C+A+A&rft.aulast=Cella&rft.aufirst=G&rft.date=1987-12-01&rft.volume=17&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+investigation&rft.issn=00142972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. AN - 77901851; 2448139 AB - The transcriptional promoter of the candidate E6-E7 transforming gene region of human papillomavirus (HPV)-16 (P97) was active in transiently transfected cervical carcinoma cells when linked to the HSV-1 tk or bacterial cat genes. Sequences 5' to P97 contain a short enhancer element responding to cellular factor(s) in uninfected human foreskin keratinocytes and in cervical carcinoma cells, but not in human or animal fibroblasts. The E2 trans-activator products of HPV-16 or of the related bovine papillomavirus (BPV)-1 further elevated HPV-16-driven transcripts in co-transfections, and required the presence of E2-binding ACC(N)6GGT cores in cis. A 'short E2' C-terminal repressor gene product (sE2) of HPV-16 or the BPV-1 sE2 repressor not only inhibited viral E2 trans-activation, but also suppressed enhancer response to keratinocytic factors. Suppression by the sE2 products was abolished by deletion of the E2-binding cores in cis or by a mutation in the sE2 DNA binding domain. The keratinocyte-dependent enhancer is likely to contribute to the epithelial cell tropism of HPV-16, and may direct persistent E6-E7 gene transcription in response to cellular factors in cervical carcinoma cells in which the viral E2 genes are inactive. JF - The EMBO journal AU - Cripe, T P AU - Haugen, T H AU - Turk, J P AU - Tabatabai, F AU - Schmid, P G AU - Dürst, M AU - Gissmann, L AU - Roman, A AU - Turek, L P AD - Department of Pathology, Veterans Administration Medical Center, Iowa City, IA 52242. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 3745 EP - 3753 VL - 6 IS - 12 SN - 0261-4189, 0261-4189 KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Animals KW - Genes KW - Transfection KW - Humans KW - Female KW - Cell Line KW - Promoter Regions, Genetic KW - Keratins -- physiology KW - Epidermis -- cytology KW - Enhancer Elements, Genetic KW - Uterine Cervical Neoplasms -- genetics KW - Transcription, Genetic KW - Papillomaviridae -- genetics KW - Genes, Viral KW - Gene Expression Regulation KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77901851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Transcriptional+regulation+of+the+human+papillomavirus-16+E6-E7+promoter+by+a+keratinocyte-dependent+enhancer%2C+and+by+viral+E2+trans-activator+and+repressor+gene+products%3A+implications+for+cervical+carcinogenesis.&rft.au=Cripe%2C+T+P%3BHaugen%2C+T+H%3BTurk%2C+J+P%3BTabatabai%2C+F%3BSchmid%2C+P+G%3BD%C3%BCrst%2C+M%3BGissmann%2C+L%3BRoman%2C+A%3BTurek%2C+L+P&rft.aulast=Cripe&rft.aufirst=T&rft.date=1987-12-01&rft.volume=6&rft.issue=12&rft.spage=3745&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 1981 Jan 30;108(2):251-5 [6258289] EMBO J. 1987 Jun;6(6):1741-6 [3038534] Proc Natl Acad Sci U S A. 1983 Jun;80(12):3812-5 [6304740] EMBO J. 1983;2(12):2341-8 [6321162] N Engl J Med. 1984 Apr 5;310(14):880-3 [6321986] EMBO J. 1984 May;3(5):1151-7 [6329740] Proc Natl Acad Sci U S A. 1984 Dec;81(24):7880-4 [6096867] J Virol. 1985 Mar;53(3):955-65 [2983102] Nature. 1985 Mar 7-13;314(6006):111-4 [2983228] Virology. 1985 Aug;145(1):181-5 [2990099] Am J Pathol. 1985 Jun;119(3):361-6 [2990217] Cell. 1985 Aug;42(1):183-91 [2990724] J Gen Virol. 1985 Jul;66 ( Pt 7):1515-22 [2991428] Proc Natl Acad Sci U S A. 1985 Aug;82(16):5540-4 [2991933] Virology. 1985 Sep;145(2):313-8 [2992153] Science. 1985 Oct 25;230(4724):442-5 [2996134] J Virol. 1986 Feb;57(2):572-7 [3003388] Proc Natl Acad Sci U S A. 1986 Apr;83(7):2200-3 [3008153] Virology. 1986 May;151(1):124-30 [3008427] CRC Crit Rev Biochem. 1986;19(4):307-22 [3009089] J Infect Dis. 1986 May;153(5):855-61 [3009636] J Virol. 1986 Jun;58(3):991-5 [3009902] Proc Natl Acad Sci U S A. 1986 Jul;83(13):4680-4 [3014503] Cell. 1986 Aug 29;46(5):753-62 [3017567] EMBO J. 1986 Aug;5(8):1945-50 [3019673] EMBO J. 1986 Sep;5(9):2285-92 [3023067] J Virol. 1987 Jan;61(1):134-42 [3023691] Virology. 1986 Dec;155(2):545-56 [3024399] Nature. 1987 Jan 1-7;325(6099):70-3 [3025749] J Virol. 1987 Apr;61(4):1061-6 [2434663] J Virol. 1987 Apr;61(4):962-71 [3029430] Proc Natl Acad Sci U S A. 1987 Feb;84(4):1070-4 [3029760] Proc Natl Acad Sci U S A. 1987 Mar;84(5):1215-8 [3029771] J Virol. 1987 May;61(5):1630-8 [3033289] J Virol. 1987 May;61(5):1686-9 [3033296] EMBO J. 1987 Jan;6(1):145-52 [3034572] EMBO J. 1987 Mar;6(3):567-75 [2438131] J Virol. 1987 Jul;61(7):2128-37 [3035214] J Virol. 1987 Jul;61(7):2240-4 [2884331] Cell. 1987 Jul 3;50(1):69-78 [3036366] EMBO J. 1987 Apr;6(4):1027-35 [3036488] EMBO J. 1987 Apr;6(4):989-92 [3036495] J Virol. 1987 Aug;61(8):2599-606 [3037119] EMBO J. 1987 May;6(5):1339-44 [3038518] Proc Natl Acad Sci U S A. 1982 Nov;79(22):6777-81 [6294651] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C. AN - 77874704; 3480042 AB - Fresh specimens of human lymphatic neoplasms were tested with the differential staining cytotoxicity assay. Cells from relapsed patients with acute lymphoblastic leukemia (ALL) were significantly more resistant to vincristine, dexamethasone, and doxorubicin in the assay than were cells from previously untreated patients. The putative C kinase inhibitors verapamil (V), imipramine (I), lidocaine (L), tamoxifen (T), chlorpromazine (C), and haloperidol (H) were then tested singly, in combination with each other (VILTCH, ITCH, and VL), and in combination with vincristine. At concentrations judged to be clinically achievable, VILTCH itself was occasionally toxic to ALL and chronic lymphocytic leukemia. The VILTCH combination clearly potentiated the cytotoxic activity of vincristine in five of eight ALL specimens from relapsed patients and potentiated vincristine in 18 of 30 chronic lymphocytic leukemia specimens. It also potentiated vincristine in two of six specimens of multiple myeloma and five of six specimens of non-Hodgkin's lymphoma. The VILTCH combination had no significant effects in fresh cultures of normal human lymphocytes. The most active drugs in the VILTCH combination appeared to be verapamil and lidocaine. We conclude that the differential staining cytotoxicity assay is a useful tool to study the circumvention of clinically acquired drug resistance. While the mechanism of the observed enhancement of the cytotoxic effects of vincristine is not known, it is possible that combinations of putative C kinase inhibitors may reduce drug resistance in human lymphatic neoplasms. JF - Cancer treatment reports AU - Weisenthal, L M AU - Su, Y Z AU - Duarte, T E AU - Dill, P L AU - Nagourney, R A AD - Veterans Administration Medical Center, Long Beach, CA. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1239 EP - 1243 VL - 71 IS - 12 SN - 0361-5960, 0361-5960 KW - Tamoxifen KW - 094ZI81Y45 KW - Lidocaine KW - 98PI200987 KW - Verapamil KW - CJ0O37KU29 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Haloperidol KW - J6292F8L3D KW - Imipramine KW - OGG85SX4E4 KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Tamoxifen -- pharmacology KW - Leukemia, Lymphoid -- drug therapy KW - Drug Resistance -- drug effects KW - Cell Survival -- drug effects KW - Humans KW - In Vitro Techniques KW - Haloperidol -- pharmacology KW - Imipramine -- pharmacology KW - Lidocaine -- pharmacology KW - Verapamil -- pharmacology KW - Drug Synergism KW - Chlorpromazine -- pharmacology KW - Leukemia -- pathology KW - Leukemia -- drug therapy KW - Protein Kinase C -- antagonists & inhibitors KW - Tumor Cells, Cultured -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77874704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reports&rft.atitle=Perturbation+of+in+vitro+drug+resistance+in+human+lymphatic+neoplasms+by+combinations+of+putative+inhibitors+of+protein+kinase+C.&rft.au=Weisenthal%2C+L+M%3BSu%2C+Y+Z%3BDuarte%2C+T+E%3BDill%2C+P+L%3BNagourney%2C+R+A&rft.aulast=Weisenthal&rft.aufirst=L&rft.date=1987-12-01&rft.volume=71&rft.issue=12&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reports&rft.issn=03615960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-03 N1 - Date created - 1988-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of irradiation on morphology and motility of canine small intestine. AN - 77852804; 3691278 AB - In addition to severe damage to the intestinal mucosa, there is evidence based on altered transit that irradiation affects intestinal motor function. A single dose of 938 cGy to the intestine of dogs consistently produced an acute intestinal radiation syndrome consisting of vomiting and diarrhea but was not lethal. In the fasting state, the migrating myoelectric complex was uniformly interrupted. After a meal, jejunal myoelectric activity analyzed by a computer program showed a progressive decline in the number, duration, and length of migration of spike bursts. There were occasionally bizarre motility patterns consisting of clusters of migrating spike bursts. Slow waves demonstrated irregular rhythm and nonuniform morphology. They occasionally migrated in an orad direction and at times were totally uncoupled. At 24 hr and four days after irradiation, the muscle and the neural plexus were nearly normal by light microscopy, but the mucosa exhibited severe necrosis. Therefore, irradiation produces profound functional abnormalities in intestinal muscle even though the morphology is minimally altered. JF - Digestive diseases and sciences AU - Summers, R W AU - Flatt, A J AU - Prihoda, M J AU - Mitros, F A AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1402 EP - 1410 VL - 32 IS - 12 SN - 0163-2116, 0163-2116 KW - Abridged Index Medicus KW - Index Medicus KW - Radiation Dosage KW - Animals KW - Dogs KW - Female KW - Gastrointestinal Motility -- radiation effects KW - Radiation Injuries, Experimental -- physiopathology KW - Intestine, Small -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77852804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Effect+of+irradiation+on+morphology+and+motility+of+canine+small+intestine.&rft.au=Summers%2C+R+W%3BFlatt%2C+A+J%3BPrihoda%2C+M+J%3BMitros%2C+F+A&rft.aulast=Summers&rft.aufirst=R&rft.date=1987-12-01&rft.volume=32&rft.issue=12&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardiac tamponade and constrictive pericarditis complicating endoscopic sclerotherapy. AN - 77839367; 3689068 AB - We report a case of suspected esophageal perforation with injection of a sclerosing agent into the pericardium during endoscopic sclerotherapy of esophageal varices. Immediately after the procedure, the patient developed fever and a pericardial friction rub. Eight months later, he presented with cardiac tamponade and constrictive pericarditis. This complication should be considered whenever a patient presents with inadequate cardiac output, venous congestion, and a pulsus paradoxus following sclerotherapy. JF - Archives of internal medicine AU - Brown, D L AU - Luchi, R J AD - Medical Service, Veterans Administration Medical Center, Houston. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 2169 EP - 2170 VL - 147 IS - 12 SN - 0003-9926, 0003-9926 KW - Sclerosing Solutions KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Wounds, Penetrating KW - Humans KW - Esophagus -- injuries KW - Adult KW - Male KW - Pericarditis, Constrictive -- chemically induced KW - Sclerosing Solutions -- adverse effects KW - Endoscopy -- adverse effects KW - Cardiac Tamponade -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77839367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Cardiac+tamponade+and+constrictive+pericarditis+complicating+endoscopic+sclerotherapy.&rft.au=Brown%2C+D+L%3BLuchi%2C+R+J&rft.aulast=Brown&rft.aufirst=D&rft.date=1987-12-01&rft.volume=147&rft.issue=12&rft.spage=2169&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Occupational Hydrocarbon Exposure and Renal Histopathology AN - 760152999; 13641421 AB - A blinded, retrospective study of histological sections from ten hydrocarbon-exposed and twenty unexposed nephrectomized renal cell carcinoma cases was conducted to evaluate the histopathologic features present in the apparently normal kidney parenchyma removed with the tumor. Tissue sections from each of the thirty cases were independently reviewed by three consulting pathologists and scored using well defined criteria. Occupational hydrocarbon exposure indices were developed by a team of industrial hygienists and applied to the detailed occupational history of each exposed case. A positive correlation was observed between age and the total renal pathology score (r sub(s) = .40, p < .03). No correlation was found between indices of occupational hydrocarbon exposure and renal pathology scores among exposed cases. No significant differences in renal pathology scores were noted when exposed cases were matched to unexposed cases by age, sex, and race. These results are limited by the inclusion of only cases with historical hydrocarbon exposures. It is recommended that a follow-up study be conducted, utilizing sensitive quantitative methods, to define what, if any, cytopathologic renal effects occur in conjunction with current occupational exposures to hydrocarbons. JF - Toxicology and Industrial Health AU - Pitha, Jan V AU - Hemstreet, George P AU - Asal, Nabih R AU - Petrone, Robert L AU - Trump, Benjamin F AU - Silva, Fred G AD - Department of Pathology Veterans Administration Medical Center Oklahoma City, Oklahoma Y1 - 1987/12// PY - 1987 DA - Dec 1987 SP - 491 EP - 506 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 3 IS - 4 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - histopathology KW - hydrocarbons KW - occupational exposure KW - renal. KW - Parenchyma KW - Age KW - renal cell carcinoma KW - Hydrocarbons KW - Reviews KW - Kidney KW - Tumors KW - Occupational exposure KW - Races KW - Sex KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760152999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Occupational+Hydrocarbon+Exposure+and+Renal+Histopathology&rft.au=Pitha%2C+Jan+V%3BHemstreet%2C+George+P%3BAsal%2C+Nabih+R%3BPetrone%2C+Robert+L%3BTrump%2C+Benjamin+F%3BSilva%2C+Fred+G&rft.aulast=Pitha&rft.aufirst=Jan&rft.date=1987-12-01&rft.volume=3&rft.issue=4&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378700300404 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 39 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Parenchyma; Age; renal cell carcinoma; Hydrocarbons; Reviews; Kidney; Tumors; Races; Occupational exposure; Sex DO - http://dx.doi.org/10.1177/074823378700300404 ER - TY - JOUR T1 - Cultural Differences in the Predictors of Depression AN - 61550517; 198800036 AB - Whether Asian Americans experience more psychological distress than native-born Caucasians was studied by examining group differences in vulnerability to stress, coping strategies, social supports, & values. Of 218 ethnic Korean & Caucasian junior & senior Coll students contacted by letter & phone, 60% responded (N = 61 Korean, 69 Caucasian) & were interviewed & given written materials to complete. It was found that: (1) values, particularly parental traditionalism, were powerful predictors of depression in Koreans; (2) these ethnic students were more likely to use coping strategies, such as controlling their feelings, that are associated with depression; & (3) parental modernism lowered depression in both groups. Contrary to Asian-American stereotypes, results show that: (A) parental achievement expectations were less important than parental traditionalism in predicting depression; (B) the Korean students were not impassive but commonly expressed anxiety & frustration as a response to academic problems; (C) neither a close-knit family nor other Asian peers were available to support the students. 5 Tables, 53 References. K. Eddy JF - American Journal of Community Psychology AU - Aldwin, Carolyn AU - Greenberger, Ellen AD - Normative Aging Study Veterans Administration Outpatient Clinic, 17 Court St Boston MA 02108 Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 789 EP - 813 VL - 15 IS - 6 SN - 0091-0562, 0091-0562 KW - depression, Korean vs Caucasian college students KW - parental modernism/traditionalism KW - interviews KW - Asian Cultural Groups KW - Depression (Psychology) KW - Sociocultural Factors KW - Cultural Values KW - College Students KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61550517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Community+Psychology&rft.atitle=Cultural+Differences+in+the+Predictors+of+Depression&rft.au=Aldwin%2C+Carolyn%3BGreenberger%2C+Ellen&rft.aulast=Aldwin&rft.aufirst=Carolyn&rft.date=1987-12-01&rft.volume=15&rft.issue=6&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Community+Psychology&rft.issn=00910562&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Sociocultural Factors; Asian Cultural Groups; College Students; Cultural Values ER - TY - JOUR T1 - Renal Innervation and Denervation: Lessons from Renal Transplantation Reconsidered AN - 1372060885; 18142268 AB - Abstract: Renal transplantation assures complete denervation of the kidney. Human renal transplantation provided an opportunity to examine the consequences of renal denervation on renal functional capacity in human subjects. These initial studies led to an anatomical and physiological assessment of the time course of renal neural degeneration and reinnervation following renal transplantation or surgical division of the renal nerves. Together with a growing body of information concerning the extensive intrinsic innervation of the kidney's structural components, there has developed a comprehensive understanding of the overall neural control of kidney function. JF - Artificial Organs AU - DiBona, Gerald F AD - Department of Internal Medicine, University of Iowa College of Medicine, and Veterans Administration Medical Center, Iowa City, Iowa, U.S.A Y1 - 1987/12// PY - 1987 DA - Dec 1987 SP - 457 EP - 462 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 6 SN - 0160-564X, 0160-564X KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Denervation KW - Kidney transplantation KW - W 30920:Tissue Engineering KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1372060885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Organs&rft.atitle=Renal+Innervation+and+Denervation%3A+Lessons+from+Renal+Transplantation+Reconsidered&rft.au=DiBona%2C+Gerald+F&rft.aulast=DiBona&rft.aufirst=Gerald&rft.date=1987-12-01&rft.volume=11&rft.issue=6&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Artificial+Organs&rft.issn=0160564X&rft_id=info:doi/10.1111%2Fj.1525-1594.1987.tb02710.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Kidney transplantation DO - http://dx.doi.org/10.1111/j.1525-1594.1987.tb02710.x ER - TY - JOUR T1 - Charged Compounds of the Glomerular Filter and Their Role in Normal and Disordered Permselectivity AN - 1372060598; 18142267 AB - Abstract: Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization or shielding of their charges. To determine the mechanism of this proteinuria, we measured the glomerular sieving coefficients of anionic and neutral forms of albumin and IgG in control and proteinuric rats. Surprisingly, these studies revealed a marked defect in size dependence, but not in charge dependence, of glomerular permselectivity in hexadimethrine-treated animals, indicating that binding of HDM induces a structural change in the glomerular filter. In vitro studies of binding of tritiated HDM and cationized ferritin to glomerular basement membrane (GBM) indicate that the binding is not dependent on proteoglycans such as heparan sulfate, nor on sialoproteins such as podocalyxin, but is dependent on charged carboxyl groups of GBM. JF - Artificial Organs AU - Hunsicker, L G AU - Bertolatus, JA AD - Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa, U.S.A Y1 - 1987/12// PY - 1987 DA - Dec 1987 SP - 468 EP - 477 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 6 SN - 0160-564X, 0160-564X KW - Biotechnology and Bioengineering Abstracts KW - Albumin KW - Proteinuria KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1372060598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Organs&rft.atitle=Charged+Compounds+of+the+Glomerular+Filter+and+Their+Role+in+Normal+and+Disordered+Permselectivity&rft.au=Hunsicker%2C+L+G%3BBertolatus%2C+JA&rft.aulast=Hunsicker&rft.aufirst=L&rft.date=1987-12-01&rft.volume=11&rft.issue=6&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Artificial+Organs&rft.issn=0160564X&rft_id=info:doi/10.1111%2Fj.1525-1594.1987.tb02712.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Proteinuria DO - http://dx.doi.org/10.1111/j.1525-1594.1987.tb02712.x ER - TY - JOUR T1 - Metoclopramide-induced normalization of impaired gastric emptying in spinal cord injury. AN - 85219489; pmid-3673993 AB - In a partial, two-way crossover study of gastric emptying (GE) in spinal cord injury (SCI), fasted, healthy, unmedicated male volunteers were given a 99mTc-labeled liquid meal on two occasions. Metoclopramide (10 mg) was administered intravenously to each subject before the second evaluation of GE. We used single and multiexponential models with linear and nonlinear least-squares regression techniques to study the time-course of the disappearance of 99mTc from the stomach. The GE pattern in all subjects was most accurately characterized by nonlinear analysis (NONLIN) and consisted of two components, an initial adynamic phase and a phase of rapid emptying. The GE t1/2 of a liquid meal decreased from 106.6 +/- 58.3 min (mean +/- SD) in all SCI subjects (quadriplegic plus paraplegic) prior to treatment to 21.6 +/- 8.2 min after the intravenous administration of metoclopramide (p less than 0.006). Significant correlations between GE t1/2 and injury duration (yr) or level of spinal injury were observed. Impaired gastric emptying in SCI can be pharmacologically modified by metoclopramide to resemble a normal gastric emptying profile. Metoclopramide-altered gastric emptying in SCI may be expected to result in changes in the therapeutic efficacy of orally administered drugs when drug absorption is dependent on gastric motility or emptying efficiency. JF - The American Journal of Gastroenterology AU - Segal, J L AU - Milne, N AU - Brunnemann, S R AU - Lyons, K P AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, California. PY - 1987 SP - 1143 EP - 1148 VL - 82 IS - 11 SN - 0002-9270, 0002-9270 KW - Regression Analysis KW - Analysis of Variance KW - Gastric Emptying KW - Injections, Intravenous KW - Human KW - Paraplegia KW - Quadriplegia KW - Metoclopramide KW - Spinal Cord Injuries KW - Comparative Study KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Time Factors KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85219489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Metoclopramide-induced+normalization+of+impaired+gastric+emptying+in+spinal+cord+injury.&rft.au=Segal%2C+J+L%3BMilne%2C+N%3BBrunnemann%2C+S+R%3BLyons%2C+K+P&rft.aulast=Segal&rft.aufirst=J&rft.date=1987-11-01&rft.volume=82&rft.issue=11&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Improved palliation of a respiratory-esophageal fistula with a cuffed esophageal prosthesis. AN - 85217484; pmid-3673997 AB - We report a case in which a traditional prosthesis failed to seal a malignant respiratory-esophageal fistula. Removal of the prosthesis and replacement with a new type with an inflatable cuff provided palliation, and allowed the patient to leave the hospital. The cuffed prosthesis provides a custom fit which should seal fistulous tracts of any shape or size, without causing tissue necrosis. JF - The American Journal of Gastroenterology AU - Smith, J L AU - Michaletz, P A AU - Tabibian, N AU - Schwartz, J T AU - Graham, D Y AD - Digestive Disease Section, Veterans Administration Medical Center, Houston, Texas. PY - 1987 SP - 1175 EP - 1176 VL - 82 IS - 11 SN - 0002-9270, 0002-9270 KW - Esophageal Neoplasms KW - Human KW - Esophagoplasty KW - Middle Age KW - Case Report KW - Carcinoma, Squamous Cell KW - Tracheoesophageal Fistula KW - Male KW - Prostheses and Implants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85217484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Improved+palliation+of+a+respiratory-esophageal+fistula+with+a+cuffed+esophageal+prosthesis.&rft.au=Smith%2C+J+L%3BMichaletz%2C+P+A%3BTabibian%2C+N%3BSchwartz%2C+J+T%3BGraham%2C+D+Y&rft.aulast=Smith&rft.aufirst=J&rft.date=1987-11-01&rft.volume=82&rft.issue=11&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A review of the published data on steroids and idiopathic facial paralysis. AN - 85209195; pmid-3120125 AB - Ever since idiopathic facial paralysis (IFP) was first described, several treatments have been tried in an effort to influence early and full recovery. Unfortunately, none of these treatments was effective. After Rothendler's case description in 1951, a multitude of papers have appeared that evaluate the effectiveness of steroids in idiopathic facial paralysis. My presentation reflects a close evaluation of 94 of these papers. Only a few properly controlled, randomized, prospective studies were available. Their main conclusion was that steroid treatment was not more beneficial than conventional treatment. To the contrary, several other less valid prospective and retrospective studies suggest that steroid treatment is beneficial. The definitive, statistically valid study concerning the benefits of steroids in treatment of idiopathic facial paralysis has yet to be performed. Until then, treatment of idiopathic facial paralysis continues to be controversial. JF - Otolaryngology--Head and Neck Surgery AU - Stankiewicz, J A AD - Department of Otolaryngology-Head and Neck Surgery, University Medical Center/Hines Veterans Administration, Maywood, IL 60153. PY - 1987 SP - 481 EP - 486 VL - 97 IS - 5 SN - 0194-5998, 0194-5998 KW - Human KW - Clinical Trials KW - Facial Paralysis KW - Adrenal Cortex Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=A+review+of+the+published+data+on+steroids+and+idiopathic+facial+paralysis.&rft.au=Stankiewicz%2C+J+A&rft.aulast=Stankiewicz&rft.aufirst=J&rft.date=1987-11-01&rft.volume=97&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Metastatic sigmoid colon adenocarcinoma to the temporal bone. AN - 85206493; pmid-3120129 JF - Otolaryngology--Head and Neck Surgery AU - Ruah, C B AU - Bohigian, R K AU - Vincent, M E AU - Vaughan, C W AD - Department of Otolaryngology, Boston Veterans Administration Medical Center, MA 02130. PY - 1987 SP - 500 EP - 503 VL - 97 IS - 5 SN - 0194-5998, 0194-5998 KW - Skull Neoplasms KW - Ear Neoplasms KW - Human KW - Ear, Middle KW - Sigmoid Neoplasms KW - Tomography, X-Ray Computed KW - Middle Age KW - Biopsy KW - Case Report KW - Adenocarcinoma KW - Temporal Bone KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85206493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Metastatic+sigmoid+colon+adenocarcinoma+to+the+temporal+bone.&rft.au=Ruah%2C+C+B%3BBohigian%2C+R+K%3BVincent%2C+M+E%3BVaughan%2C+C+W&rft.aulast=Ruah&rft.aufirst=C&rft.date=1987-11-01&rft.volume=97&rft.issue=5&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Error analysis and passage dependency of test items from a standardized test of multiple-sentence reading comprehension for aphasic and non-brain-damaged adults. AN - 85167358; pmid-2444768 AB - Aphasic and non-brain-damaged adults were tested with two forms of the Nelson Reading Skills Test (NRST; Hanna. Schell, & Schreiner, 1977). The NRST is a standardized measure of silent reading for students in Grades 3 through 9 and assesses comprehension of information at three levels of inference (literal, translational, and higher level). Subjects' responses to NRST test items were evaluated to determine if their performance differed on literal, translational, and higher level items. Subjects' performance was also evaluated to determine the passage dependency of NRST test items--the extent to which readers had to rely on information in the NRST reading passages to answer test items. Higher level NRST test items (requiring complex inferences) were significantly more difficult for both non-brain-damaged and aphasic adults than literal items (not requiring inferences) or translational items (requiring simple inferences). The passage dependency of NRST test items for aphasic readers was higher than those reported by Nicholas, MacLennan, and Brookshire (1986) for multiple-sentence reading tests designed for aphasic adults. This suggests that the NRST is a more valid measure of the multiple-sentence reading comprehension of aphasic adults than the other tests evaluated by Nicholas et al. (1986). JF - The Journal of Speech and Hearing Disorders AU - Nicholas, L E AU - Brookshire, Robert H AD - Veterans Administration Medical Center, Minneapolis, MN. PY - 1987 SP - 358 EP - 366 VL - 52 IS - 4 SN - 0022-4677, 0022-4677 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85167358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Error+analysis+and+passage+dependency+of+test+items+from+a+standardized+test+of+multiple-sentence+reading+comprehension+for+aphasic+and+non-brain-damaged+adults.&rft.au=Nicholas%2C+L+E%3BBrookshire%2C+Robert+H&rft.aulast=Nicholas&rft.aufirst=L&rft.date=1987-11-01&rft.volume=52&rft.issue=4&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Speech+and+Hearing+Disorders&rft.issn=00224677&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier. AN - 81119413; 3679092 AB - Brain edema is a major complication of fulminant hepatic failure and is responsible for death in a large percentage of patients. We previously demonstrated the progressive accumulation of water in grey matter areas of the brain in the rabbit with galactosamine-induced fulminant hepatic failure. We now report the electron microscopic morphology of the brain in the same model of acute hepatic failure following the intravenous injection of horseradish peroxidase, an intravascular tracer which forms an electron-dense reaction product. Rabbits with both mild and severe encephalopathy had normal blood pressures and blood gases at the time of study. Fixation of brain tissue was obtained by whole-body perfusion. Marked swelling of the cytoplasm, perineuronal and perivascular processes of astrocytes were noted in cortical gray, but not white, matter areas; the other cellular components of the brain had normal morphology. Capillary endothelial cells were normal, and there was no evidence of horseradish peroxidase in endothelial cell vesicles, basement membranes or the brain parenchyma, suggesting that the blood-brain barrier was impermeable to large molecules. Histologic evidence of brain edema is seen in this model, with swelling of astrocytes as the primary manifestation of the accumulation of water. Damage to astrocytes or inhibition of their function may contribute to the pathogenesis of hepatic encephalopathy in this model. JF - Hepatology (Baltimore, Md.) AU - Traber, P G AU - Dal Canto, M AU - Ganger, D R AU - Blei, A T AD - Department of Medicine, Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611. PY - 1987 SP - 1272 EP - 1277 VL - 7 IS - 6 SN - 0270-9139, 0270-9139 KW - Galactosamine KW - 7535-00-4 KW - Index Medicus KW - Animals KW - Chemical and Drug Induced Liver Injury KW - Rabbits KW - Microscopy, Electron KW - Male KW - Brain -- pathology KW - Liver Diseases -- pathology KW - Brain -- ultrastructure KW - Brain Edema -- pathology KW - Blood-Brain Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81119413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Electron+microscopic+evaluation+of+brain+edema+in+rabbits+with+galactosamine-induced+fulminant+hepatic+failure%3A+ultrastructure+and+integrity+of+the+blood-brain+barrier.&rft.au=Traber%2C+P+G%3BDal+Canto%2C+M%3BGanger%2C+D+R%3BBlei%2C+A+T&rft.aulast=Traber&rft.aufirst=P&rft.date=1987-11-01&rft.volume=7&rft.issue=6&rft.spage=1272&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-21 N1 - Date created - 1988-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent. AN - 81074032; 2822868 AB - Biologic distribution data in the rat were obtained for the alpha-1 adrenoceptor imaging agent (+/-) 2-[beta-(iodo-4-hydroxyphenyl)ethylaminomethyl]tetralone (HEAT) labeled with [125I]. The major excretory routes were through the liver (67%) and the kidney (33%). Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads, and red bone marrow were calculated for the human using the physical decay data for [123I]. The critical organ was found to be the lower large intestine, receiving 1.1 rad per mCi of [123I]HEAT administered. The total-body dose was found to be 58 mrad per mCi. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Thomas, K D AU - Greer, D M AU - Couch, M W AU - Williams, C M AD - Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1745 EP - 1750 VL - 28 IS - 11 SN - 0161-5505, 0161-5505 KW - Iodine Radioisotopes KW - 0 KW - Phenethylamines KW - Receptors, Adrenergic, alpha KW - Tetralones KW - 2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone KW - 95034-25-6 KW - Index Medicus KW - Rats KW - Radiation Dosage KW - Animals KW - Humans KW - Adult KW - Tissue Distribution KW - Male KW - Radionuclide Imaging KW - Phenethylamines -- metabolism KW - Receptors, Adrenergic, alpha -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81074032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Radiation+dosimetry+of+iodine-123+HEAT%2C+an+alpha-1+receptor+imaging+agent.&rft.au=Thomas%2C+K+D%3BGreer%2C+D+M%3BCouch%2C+M+W%3BWilliams%2C+C+M&rft.aulast=Thomas&rft.aufirst=K&rft.date=1987-11-01&rft.volume=28&rft.issue=11&rft.spage=1745&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypersomnolence with beta-adrenergic blockers. AN - 81072511; 3665616 AB - An elderly, mildly demented, hypertensive male patient developed hypersomnolence on administration of propranolol for treatment of hypertension; no other cause for hypersomnolence was detected. Upon replacement of propranolol with atenolol, he felt better but continued to be quite somnolent. When atenolol was discontinued, he reported to have lack of sleep. On readministration of subtherapeutic doses of the same beta-adrenergic blocking agents, he once again experienced excessive sleepiness. By discontinuing beta-blocking agents and introducing captopril, he felt much better, became pleasant and talkative, and blood pressure was well controlled. Beta antagonists are important drugs in the management of many cardiovascular problems. Propranolol, a lipophilic beta-blocking agent, and atenolol, a hydrophilic beta-blocking agent, are two of the major agents currently used clinically in the United States. Numerous neuropsychiatric side-effects of the beta-adrenergic blocking drugs have been reported, but hypersomnolence is not readily recognized as one of them. JF - Chest AU - Thachil, J AU - Zeller, J R AU - Kochar, M S AD - Hypertension Section, Zablocki Veterans Administration Medical Center, Milwaukee 53295. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 943 EP - 944 VL - 92 IS - 5 SN - 0012-3692, 0012-3692 KW - Atenolol KW - 50VV3VW0TI KW - Propranolol KW - 9Y8NXQ24VQ KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Hypertension -- drug therapy KW - Sleep Wake Disorders -- chemically induced KW - Disorders of Excessive Somnolence -- chemically induced KW - Atenolol -- adverse effects KW - Propranolol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81072511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Hypersomnolence+with+beta-adrenergic+blockers.&rft.au=Thachil%2C+J%3BZeller%2C+J+R%3BKochar%2C+M+S&rft.aulast=Thachil&rft.aufirst=J&rft.date=1987-11-01&rft.volume=92&rft.issue=5&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-09 N1 - Date created - 1987-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific induction of local antitumor effector cells mediated in vivo by the circulating lymphocyte pool. AN - 81060062; 3311355 AB - Wistar rats are specifically resistant to the growth of the chemical carcinogen induced syngeneic tumors, Mc7 and Mc107 sarcoma, after being immunized with s.c. implants of irradiated tumor tissue. The central lymph of such immunized rats contains cells able to systemically transfer resistance against tumor growth to normal or irradiated recipient rats. The thoracic duct lymphocytes (TDL) from tumor immune donors are not directly cytotoxic against tumor targets. However recipients of i.v. infused immune TDL develop cytotoxic activity in the peritoneal cavity when challenged with the immunizing tumor at that site. Although the induction of maximum cytotoxicity is tumor specific, peritoneal lavage cells are cytotoxic against both Mc7 and Mc107 tumor targets in the 51Cr release assay. Inhibition of cytotoxicity in the assay by addition of unlabeled Mc7 or Mc107 sarcoma cells to labeled tumor targets suggests that there is both specific and nonspecific activity in these peritoneal lavage cells. Resistance to in vivo tumor growth in adoptively immunized recipients of TDL challenged with both Mc7 and Mc107 is specific for the immunizing tumor. However growth of a mixture of Mc7 and Mc107 sarcoma cells is inhibited in recipients of immune TDL. The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally. These effectors are at least in part nonspecific in their cytotoxic activity. JF - Cancer research AU - Crum, E D AD - Hematology/Oncology Section, Cleveland Veterans Administration Medical Center, Ohio. Y1 - 1987/11/01/ PY - 1987 DA - 1987 Nov 01 SP - 5584 EP - 5589 VL - 47 IS - 21 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Cytotoxicity, Immunologic KW - Animals KW - Whole-Body Irradiation KW - Immunization, Passive KW - Sarcoma, Experimental -- pathology KW - Sarcoma, Experimental -- immunology KW - Female KW - Lymphocytes -- immunology KW - Neoplasms, Experimental -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81060062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Specific+induction+of+local+antitumor+effector+cells+mediated+in+vivo+by+the+circulating+lymphocyte+pool.&rft.au=Crum%2C+E+D&rft.aulast=Crum&rft.aufirst=E&rft.date=1987-11-01&rft.volume=47&rft.issue=21&rft.spage=5584&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-03 N1 - Date created - 1987-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro production of cholera toxin-like activity by Plesiomonas shigelloides. AN - 81036468; 3655401 AB - Although Plesiomonas shigelloides is considered to cause diarrhea in humans, the mechanisms by which it might do so are not known. Enteric pathogens such as Vibrio cholerae and some strains of Escherichia coli produce enterotoxins that activate adenylate cyclase, increase production of cyclic AMP, and thereby cause elongation of Chinese hamster ovary (CHO) cells in tissue culture. We grew 28 strains of P. shigelloides and the type strain in an iron-depleted medium, and sterile filtrates were examined in CHO cell culture. Filtrates from 24 of the 29 strains produced elongation of CHO cells. These changes could be prevented by heating or by preincubation of the filtrate with cholera antitoxin. These data indicate that P. shigelloides elaborates a cholera-like toxin; such a substance might be important in the pathogenesis of P. shigelloides-associated diarrhea. JF - The Journal of infectious diseases AU - Gardner, S E AU - Fowlston, S E AU - George, W L AD - West Los Angeles Veterans Administration Medical Center, California 90073. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 720 EP - 722 VL - 156 IS - 5 SN - 0022-1899, 0022-1899 KW - Antibodies, Bacterial KW - 0 KW - Culture Media KW - Enterotoxins KW - Cholera Toxin KW - 9012-63-9 KW - Abridged Index Medicus KW - Index Medicus KW - Hot Temperature KW - Animals KW - Cells, Cultured KW - Humans KW - Diarrhea -- microbiology KW - Antibodies, Bacterial -- administration & dosage KW - Cholera Toxin -- biosynthesis KW - Enterotoxins -- biosynthesis KW - Cholera Toxin -- pharmacology KW - Enterotoxins -- pharmacology KW - Vibrionaceae -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81036468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=In+vitro+production+of+cholera+toxin-like+activity+by+Plesiomonas+shigelloides.&rft.au=Gardner%2C+S+E%3BFowlston%2C+S+E%3BGeorge%2C+W+L&rft.aulast=Gardner&rft.aufirst=S&rft.date=1987-11-01&rft.volume=156&rft.issue=5&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-18 N1 - Date created - 1987-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rheumatic manifestations of diseases associated with substance abuse. AN - 78057255; 3334286 AB - Rheumatic manifestations of substance abuse are uncommon but recognized complications. Repeated injections of drugs and adulterants represent repeated antigenic challenge. The population at greatest risk is that of young males, although females with eating disorders are more apt to develop myopathy, clubbing, or periostitis. Alcohol, the most common substance abused, is associated more often with myopathy. In IV drug abusers, hepatitis B viral infection, bacterial endocarditis, primary skeletal infections, and venous complications are most common in that order. However, the spectrum may evolve as the pattern of substance abuse changes. First, the frequency of cocaine dependence is rapidly approaching that of alcohol. Two regular cocaine users are reported as having Raynaud's phenomenon and abnormal serologies. Second, synthesis of lookalike drugs may produce new associations, such as parkinsonism after IV N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Third, the increased use of ipecac and purgatives in eating disorders is an important consideration in young women with otherwise unexplained myopathy or arthritis. Finally, patients with AIDS are presenting with autoimmune phenomena or a spectrum of unusual infections that change as the epidemic evolves. Increased recognition of these symptom complexes may lead to earlier, more accurate diagnoses and avoidance of unnecessary diagnostic evaluations and delays in treatment. JF - Seminars in arthritis and rheumatism AU - Lohr, K M AD - Department of Medicine, Veterans Administration Medical Center, Milwaukee, WI. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 90 EP - 111 VL - 17 IS - 2 SN - 0049-0172, 0049-0172 KW - Index Medicus KW - Vascular Diseases -- chemically induced KW - Muscular Diseases -- chemically induced KW - Humans KW - Amyloidosis -- chemically induced KW - Arthritis, Infectious -- chemically induced KW - Periostitis -- chemically induced KW - Alcoholism -- complications KW - Rheumatic Diseases -- chemically induced KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78057255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+arthritis+and+rheumatism&rft.atitle=Rheumatic+manifestations+of+diseases+associated+with+substance+abuse.&rft.au=Lohr%2C+K+M&rft.aulast=Lohr&rft.aufirst=K&rft.date=1987-11-01&rft.volume=17&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Seminars+in+arthritis+and+rheumatism&rft.issn=00490172&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-30 N1 - Date created - 1989-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heparin-associated thrombocytopenia in maintenance hemodialysis patients. AN - 77971999; 3443522 AB - Thrombocytopenia associated with the presence of a heparin-dependent platelet aggregating factor developed in two patients after hemodialysis with heparin. It resolved in one patient after heparin was stopped; but persisted in the other during a two-week heparin-free period and intermittently thereafter. We suggest that when heparin causes thrombocytopenia in dialysis patients the heparin should be stopped whenever possible, but this may not be necessary in all patients. JF - The International journal of artificial organs AU - Leehey, D J AU - Kanak, R J AU - Messmore, H L AU - Nawab, Z M AU - Popli, S AU - Ing, T S AD - Veterans Administration Hospital, Hines, Illinois. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 390 EP - 392 VL - 10 IS - 6 SN - 0391-3988, 0391-3988 KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - Humans KW - Middle Aged KW - Platelet Aggregation -- drug effects KW - Male KW - Renal Dialysis -- methods KW - Thrombocytopenia -- chemically induced KW - Heparin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77971999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+artificial+organs&rft.atitle=Heparin-associated+thrombocytopenia+in+maintenance+hemodialysis+patients.&rft.au=Leehey%2C+D+J%3BKanak%2C+R+J%3BMessmore%2C+H+L%3BNawab%2C+Z+M%3BPopli%2C+S%3BIng%2C+T+S&rft.aulast=Leehey&rft.aufirst=D&rft.date=1987-11-01&rft.volume=10&rft.issue=6&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+artificial+organs&rft.issn=03913988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-10 N1 - Date created - 1988-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. AN - 77950216; 3437247 AB - Alphaxalone is considered the anaesthetic of choice in neuroendocrine reproductive studies in female rats, since it appears to have little, if any, effect on release of gonadotrophin-releasing hormone. There has been less study of the effects of this anaesthetic on the male reproductive neuroendocrine axis, however. Accordingly, the time-dependent effects of alphaxalone, as well as of urethane and ketamine, on the increased levels of LH in castrated rats were determined. Each anaesthetic was administered i.p. and each depressed LH levels significantly compared with those in castrated unanaesthetized rats killed by decapitation (controls). The effect of the anaesthetics was noted 15 min after administration and persisted at 30 and 60 min in animals anaesthetized with alphaxalone and urethane. Only in ketamine-anaesthetized animals did serum concentrations of LH finally rise to concentrations not significantly different from those in control rats. Thus alphaxalone, though useful in female neuroendocrine studies, is as profoundly disruptive as other anaesthetics on the male rat hypothalamic-pituitary reproductive unit. JF - The Journal of endocrinology AU - Emanuele, M A AU - Tentler, J AU - Kirsteins, L AU - Reda, D AU - Emanuele, N V AU - Lawrence, A M AD - Research and Medical Services, Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 221 EP - 223 VL - 115 IS - 2 SN - 0022-0795, 0022-0795 KW - Anesthetics KW - 0 KW - Pregnanediones KW - Urethane KW - 3IN71E75Z5 KW - Ketamine KW - 690G0D6V8H KW - Luteinizing Hormone KW - 9002-67-9 KW - alphaxalone KW - BD07M97B2A KW - alphadolone KW - OE1C96974E KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Male KW - Depression, Chemical KW - Luteinizing Hormone -- blood KW - Orchiectomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77950216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Anaesthesia+with+alphaxalone+plus+alphadolone+acetate+decreases+serum+concentrations+of+LH+in+castrated+rats.&rft.au=Emanuele%2C+M+A%3BTentler%2C+J%3BKirsteins%2C+L%3BReda%2C+D%3BEmanuele%2C+N+V%3BLawrence%2C+A+M&rft.aulast=Emanuele&rft.aufirst=M&rft.date=1987-11-01&rft.volume=115&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=00220795&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-28 N1 - Date created - 1988-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolite profile in milk of lactating rats after treatment with a carcinogen, N-2-fluorenylacetamide. AN - 77947663; 2893699 AB - Metabolites were determined in milk and urine of lactating rats 4 to 5 hr after each of 3 to 6 ip injections of N-2-fluorenylacetamide (2-FAA) at 0.2 mmol/kg of body weight. Milk contained 2-FAA as the major free compound, variable amounts of N-2-fluorenamine (2-FA) and phenols (7- greater than 5- greater than 3-hydroxy-2-FAA) chiefly as glucuronides, and very small amounts of the glucuronide of N-hydroxy-2-FAA. Urine contained large amounts of the phenols and N-hydroxy-2-FAA as free and conjugated compounds, but in contrast to milk, only small amounts of 2-FAA and no 2-FA. Pretreatment of rats with beta-napthoflavone, an inducer of microsomal C- and N-hydroxylations of 2-FAA, increased the amounts of 3- and 5-hydroxy-2-FAA in milk and of 3-hydroxy-2-FAA in urine. However, the total amounts of the compounds excreted in 1 ml of milk or urine, i.e. 0.05 to 0.13% or 0.6% of the dose of 2-FAA, respectively, were similar in the uninduced and induced groups. Protein hydrolysates of milk of 2-FAA-treated rats and of milk interacted with 2-nitrosofluorene (2-NOF) in vitro both contained 2-FA and 9-oxo-2-FA. This suggested formation of 2-NOF in vivo possibly by peroxidative metabolism of N-OH-2-FAA. Since 2-NOF has been reported to form adducts with unsaturated lipids, the effect of treatment of lactating rats with 2-FAA on the fatty acid composition of milk lipids was examined.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Drug metabolism and disposition: the biological fate of chemicals AU - Malejka-Giganti, D AU - Magat, W J AU - Adelmann, A M AU - Decker, R W AD - Laboratory for Cancer Research, Veterans Administration Medical Center, Minneapolis, MN 55417. PY - 1987 SP - 760 EP - 766 VL - 15 IS - 6 SN - 0090-9556, 0090-9556 KW - Carcinogens KW - 0 KW - Fatty Acids KW - Triglycerides KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Niridazole KW - N116U8Y5QQ KW - Index Medicus KW - Animals KW - Humans KW - Infant, Newborn KW - Niridazole -- pharmacology KW - Chromatography, High Pressure Liquid KW - Fatty Acids -- metabolism KW - Lactation KW - Pregnancy KW - Rats, Inbred Strains KW - Rats KW - Biotransformation KW - Triglycerides -- metabolism KW - Female KW - Lipid Metabolism KW - Male KW - Milk -- metabolism KW - Carcinogens -- pharmacokinetics KW - 2-Acetylaminofluorene -- pharmacokinetics KW - 2-Acetylaminofluorene -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77947663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Metabolite+profile+in+milk+of+lactating+rats+after+treatment+with+a+carcinogen%2C+N-2-fluorenylacetamide.&rft.au=Malejka-Giganti%2C+D%3BMagat%2C+W+J%3BAdelmann%2C+A+M%3BDecker%2C+R+W&rft.aulast=Malejka-Giganti&rft.aufirst=D&rft.date=1987-11-01&rft.volume=15&rft.issue=6&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stereotypic wall climbing in mice during ethanol withdrawal: a new measure of physical dependence. AN - 77935952; 3435633 AB - A new potentially useful measure for assessing physical dependence in mice chronically exposed to ethanol is described. C3H/He mice continuously exposed to ethanol vapor for four (Experiment 1) or three (Experiment 2) days spent more time engaged in stereotypic climbing behavior than controls. This stereotypic climbing behavior correlated well, both temporally as well as in intensity, with other previously described signs of ethanol withdrawal. All measures of withdrawal behavior (including climbing) peaked at eight hours after withdrawal and returned to control levels by 30-33 hours. The utility of this behavioral assay for assessing physical dependence on ethanol is further discussed with reference to possible underlying neurochemical events. JF - Alcohol (Fayetteville, N.Y.) AU - Becker, H C AU - Anton, R F AU - Randall, C L AD - Research Service, Veterans Administration Medical Center, Charleston, SC 29403. PY - 1987 SP - 443 EP - 447 VL - 4 IS - 6 SN - 0741-8329, 0741-8329 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Ethanol -- adverse effects KW - Animals KW - Mice, Inbred C3H KW - Mice KW - Male KW - Substance Withdrawal Syndrome KW - Stereotyped Behavior -- physiology KW - Behavior, Animal -- physiology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77935952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Stereotypic+wall+climbing+in+mice+during+ethanol+withdrawal%3A+a+new+measure+of+physical+dependence.&rft.au=Becker%2C+H+C%3BAnton%2C+R+F%3BRandall%2C+C+L&rft.aulast=Becker&rft.aufirst=H&rft.date=1987-11-01&rft.volume=4&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethchlorvynol-induced pulmonary edema: a chronically instrumented, awake sheep model mimicking human disease. AN - 77921246; 3425581 AB - Ethchlorvynol injection in humans leads to a clinical picture consistent with increased permeability pulmonary edema, ie, the adult respiratory distress syndrome. There has been only one such case reported in which the pulmonary wedge pressure was measured. In an attempt to mimic the human disease, the authors established the awake, unanesthetized chronic sheep lung lymph fistula model and injected 15 mg/kg of ethchlorvynol intravenously after a baseline period. There were transient increases in pulmonary artery and systemic blood pressure with decreases in cardiac output. Lymph flow increased five-fold and remained elevated for 24 hr, returning to normal by 48 hr. All animals survived. Pulmonary morphologic changes consisted of alveolar and interstitial edema and some disruption of endothelial and epithelial cells. These findings resolved by 48 hr postinjection. The authors conclude that this model mimics the findings in humans who have injected ethchlorvynol intravenously. JF - The American journal of the medical sciences AU - Garnett, R AU - Fairman, R P AU - Glauser, F L AD - Department of Internal Medicine, Medical College of Virginia/McGuire Veterans Administration Hospitals, Richmond 23298-0001. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 317 EP - 323 VL - 294 IS - 5 SN - 0002-9629, 0002-9629 KW - Ethchlorvynol KW - 6EIM3851UZ KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cardiac Output KW - Lymph -- physiology KW - Blood Pressure KW - Sheep KW - Lung -- ultrastructure KW - Pulmonary Wedge Pressure KW - Fistula KW - Pulmonary Edema -- chemically induced KW - Disease Models, Animal KW - Pulmonary Edema -- physiopathology KW - Pulmonary Edema -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77921246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Ethchlorvynol-induced+pulmonary+edema%3A+a+chronically+instrumented%2C+awake+sheep+model+mimicking+human+disease.&rft.au=Garnett%2C+R%3BFairman%2C+R+P%3BGlauser%2C+F+L&rft.aulast=Garnett&rft.aufirst=R&rft.date=1987-11-01&rft.volume=294&rft.issue=5&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. AN - 77918829; 3322269 AB - The mechanisms by which platelet-activating factor (PAF) and thrombin increase intracellular calcium were examined. Platelets were loaded with the calcium-sensitive fluorescent probe Quin 2 and then were suspended in buffer containing 0.5 mM-Mn2+ in order to quantify simultaneously calcium release from intracellular stores and divalent cation influx. Pretreating platelets with agents which activate protein kinase C [the phorbol ester phorbol myristate acetate (PMA) or the diacylglycerol 1-oleoyl-2-acetylglycerol (OAG)] inhibited increased intracellular calcium by PAF and thrombin in a dose-related manner. That protein kinase C regulates intracellular calcium by phosphorylating proteins in two distinct pathways was suggested by two observations. PAF-induced calcium release was more sensitive to inhibition by PMA and OAG than was manganese influx and the kinetics of recovery from inhibition were different for the two pathways. Both PMA and OAG aggregated Quin 2-loaded platelets without eliciting measurable increases in intracellular calcium. In contrast, prostacyclin, which increases intracellular cyclic AMP, inhibited calcium release and influx in parallel, suggesting that this agent acts at a step common to both pathways. JF - The Biochemical journal AU - Valone, F H AU - Johnson, B AD - Veterans Administration Medical Center, Cancer Research Institute, San Francisco, CA 94121. Y1 - 1987/11/01/ PY - 1987 DA - 1987 Nov 01 SP - 669 EP - 674 VL - 247 IS - 3 SN - 0264-6021, 0264-6021 KW - Cations, Divalent KW - 0 KW - Diglycerides KW - Platelet Activating Factor KW - 1-oleoyl-2-acetylglycerol KW - 86390-77-4 KW - Epoprostenol KW - DCR9Z582X0 KW - Thrombin KW - EC 3.4.21.5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Diglycerides -- pharmacology KW - Spectrometry, Fluorescence KW - Epoprostenol -- pharmacology KW - Thrombin -- pharmacology KW - Humans KW - Intracellular Fluid -- metabolism KW - Intracellular Fluid -- drug effects KW - Cations, Divalent -- blood KW - Calcium -- blood KW - Platelet Activating Factor -- metabolism KW - Blood Platelets -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Blood Platelets -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77918829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Modulation+of+platelet-activating-factor-induced+calcium+influx+and+intracellular+calcium+release+in+platelets+by+phorbol+esters.&rft.au=Valone%2C+F+H%3BJohnson%2C+B&rft.aulast=Valone&rft.aufirst=F&rft.date=1987-11-01&rft.volume=247&rft.issue=3&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-04 N1 - Date created - 1988-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1979 Apr;63(4):580-7 [220279] Thromb Res. 1987 Mar 1;45(5):427-35 [3590086] J Immunol. 1982 Oct;129(4):1637-41 [6286773] Eur J Biochem. 1984 Apr 2;140(1):129-36 [6705791] Nature. 1984 May 3-9;309(5963):66-8 [6201746] Biochem J. 1984 Mar 15;218(3):819-27 [6426464] FEBS Lett. 1984 Aug 6;173(2):389-93 [6235130] Nature. 1984 Nov 22-28;312(5992):315-21 [6095092] J Immunol. 1985 Feb;134(2):1120-4 [2578151] J Biol Chem. 1985 Feb 25;260(4):2069-76 [3918996] Biochem Biophys Res Commun. 1985 Feb 28;127(1):161-7 [2579649] J Biol Chem. 1985 May 10;260(9):5236-9 [2985584] FEBS Lett. 1985 Jul 8;186(2):175-9 [2408921] Eur J Biochem. 1985 Sep 2;151(2):425-30 [4040856] Biochem Biophys Res Commun. 1985 Nov 27;133(1):98-104 [3935114] Thromb Res. 1985 Nov 1;40(3):385-92 [4082115] Biochim Biophys Acta. 1986 Feb 12;875(2):157-64 [3080024] Blood. 1986 Feb;67(2):354-61 [3510678] Thromb Res. 1986 Jan 15;41(2):251-62 [3961730] Biochem J. 1986 Feb 1;233(3):707-18 [2939827] Arch Biochem Biophys. 1987 Jan;252(1):259-68 [3101596] Biochem Biophys Res Commun. 1979 Sep 12;90(1):92-8 [227395] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Early pulmonary endothelial enzyme dysfunction after phorbol ester in conscious rabbits. AN - 77884217; 3693230 AB - We investigated changes in angiotensin converting-enzyme (ACE) activity before and at 5, 15, 60, and 240 min after 20 micrograms phorbol myristate acetate/kg body wt iv in conscious rabbits. ACE activity was estimated in vivo from the single-pass transpulmonary metabolism of the synthetic substrate [3H]benzoyl-Phe-Ala-Pro [( 3H]BPAP) under first-order reaction conditions. Within 5 min after PMA administration, all animals developed profound granulocytopenia (15% of control) and moderate thrombocytopenia (57% of control), both lasting for the duration of the experiment. Concomitantly, there was a significant decrease in the transpulmonary metabolism of [3H]BPAP and the calculated apparent first-order reaction constant Amax/Km of ACE for [3H]BPAP. No histological evidence of lung injury was observed at these times. Since a concomitant fall in the permeability surface area product for urea was also observed, we considered that the apparent decline in ACE activity might have resulted from a reduction in perfused endothelial surface area. To resolve this, we studied the effect of PMA on the Km (a measure of enzyme affinity for its substrate) and Amax (a derivative of Vmax that is dependent upon total enzyme present and thus capillary surface area) of ACE and 5'-nucleotidase for [3H]BPAP and [14C]AMP, respectively. A significant increase in Km for both enzymes was observed at 1 h after PMA, whereas Amax was unaffected, suggesting that low-dose PMA may indeed produce endothelial cell enzyme dysfunction independent of its effect on capillary surface area. These results provide evidence of pulmonary capillary functional injury before or in the absence of structural endothelial damage. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - McCormick, J R AU - Chrzanowski, R AU - Andreani, J AU - Catravas, J D AD - Veterans Administration Medical Center, Augusta, Georgia. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1972 EP - 1978 VL - 63 IS - 5 SN - 8750-7587, 8750-7587 KW - Oligopeptides KW - 0 KW - Adenosine Monophosphate KW - 415SHH325A KW - benzoylphenylalanyl-alanyl-proline KW - 69677-91-4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Adenosine Monophosphate -- metabolism KW - Kinetics KW - Oligopeptides -- metabolism KW - Rabbits KW - Female KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Pulmonary Artery -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pulmonary Artery -- enzymology KW - Pulmonary Artery -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77884217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Early+pulmonary+endothelial+enzyme+dysfunction+after+phorbol+ester+in+conscious+rabbits.&rft.au=McCormick%2C+J+R%3BChrzanowski%2C+R%3BAndreani%2C+J%3BCatravas%2C+J+D&rft.aulast=McCormick&rft.aufirst=J&rft.date=1987-11-01&rft.volume=63&rft.issue=5&rft.spage=1972&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The nurse in a methadone maintenance clinic. Revisited. AN - 77866583; 3694559 JF - Journal of psychosocial nursing and mental health services AU - Chenitz, W C AU - Krumenaker, C AD - Nursing Service for Research, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 13 EP - 17 VL - 25 IS - 11 SN - 0279-3695, 0279-3695 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Nursing KW - Patient Care Team KW - Humans KW - Nurse-Patient Relations KW - Male KW - Methadone -- therapeutic use KW - Nurses KW - Role KW - Opioid-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77866583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=The+nurse+in+a+methadone+maintenance+clinic.+Revisited.&rft.au=Chenitz%2C+W+C%3BKrumenaker%2C+C&rft.aulast=Chenitz&rft.aufirst=W&rft.date=1987-11-01&rft.volume=25&rft.issue=11&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-04 N1 - Date created - 1988-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monokine-induced acute lung injury in rabbits. AN - 77863461; 3500942 AB - Interleukin-1 (IL-1) mediates components of the acute phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied in unanesthetized rabbits the effects of intravenous divided dose infusions of a murine monokine preparation containing IL-1 activity, on circulating granulocytes, their sequestration within the pulmonary microvasculature, pulmonary edema formation, and changes in pulmonary vascular permeability. Monokine administration induced significant (P less than 0.01) granulocytopenia as well as a significant (P less than 0.001) increase in mean alveolar septal wall granulocytes per high power field (HPF) compared with saline-injected controls. Infusions of the monokine preparation significantly (P less than 0.005) increased lung wet-to-dry weight ratios as well as significantly (P less than 0.025) increased pulmonary extravasation of radiolabeled albumin. Electron microscopic analysis of lung sections obtained from monokine-infused animals demonstrated endothelial injury, perivascular edema, and extravasation of an ultrastructural tracer. We conclude that a monokine preparation containing IL-1 activity can induce profound granulocytopenia, pulmonary leukostasis, and acute pulmonary vascular endothelial injury. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Goldblum, S E AU - Jay, M AU - Yoneda, K AU - Cohen, D A AU - McClain, C J AU - Gillespie, M N AD - Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 2093 EP - 2100 VL - 63 IS - 5 SN - 8750-7587, 8750-7587 KW - Interleukin-1 KW - 0 KW - Index Medicus KW - Granulocytes KW - Leukocyte Count -- drug effects KW - Animals KW - Pulmonary Alveoli -- immunology KW - Pulmonary Alveoli -- drug effects KW - Lung -- ultrastructure KW - Lung -- drug effects KW - Rabbits KW - Microscopy, Electron KW - Lung -- pathology KW - Pulmonary Edema -- chemically induced KW - Capillary Permeability -- drug effects KW - Interleukin-1 -- toxicity KW - Agranulocytosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77863461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Monokine-induced+acute+lung+injury+in+rabbits.&rft.au=Goldblum%2C+S+E%3BJay%2C+M%3BYoneda%2C+K%3BCohen%2C+D+A%3BMcClain%2C+C+J%3BGillespie%2C+M+N&rft.aulast=Goldblum&rft.aufirst=S&rft.date=1987-11-01&rft.volume=63&rft.issue=5&rft.spage=2093&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Substance use and mental health problems among sons of alcoholics and controls. AN - 77839783; 3682826 AB - Data from a questionnaire sent to 864 university male students and nonacademic staff were used to compare self-reports of substance intake patterns and problems as well as family histories of depression and substance abuse across four groups: Group 1, 682 men (79%) who had no alcoholic first or second-degree relative; Group 2, 101 men (12%) who reported an alcoholic second-degree relative only; Group 3, 59 men (7%) who reported an alcoholic first-degree relative only and Group 4, 22 men (3%) with alcoholism in both first- and second-degree relatives. Although few men were already alcoholics or drug abusers and the groups did not differ significantly on the quantity and frequency of alcohol intake, there was an increase in the personal history of alcohol-related problems from Group 1 to Group 4. There were no significant differences across the groups on the proportion of nonalcoholic relatives demonstrating drug abuse or depressive disorders. JF - Journal of studies on alcohol AU - Schuckit, M A AU - Sweeney, S AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 528 EP - 534 VL - 48 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Anxiety Disorders -- genetics KW - Risk Factors KW - Humans KW - Adult KW - Depressive Disorder -- genetics KW - Schizophrenia -- genetics KW - Male KW - Psychological Tests KW - Mental Disorders -- genetics KW - Alcoholism -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77839783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Substance+use+and+mental+health+problems+among+sons+of+alcoholics+and+controls.&rft.au=Schuckit%2C+M+A%3BSweeney%2C+S&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1987-11-01&rft.volume=48&rft.issue=6&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-14 N1 - Date created - 1988-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of cholesterol-induced atherosclerosis in rabbits by dimethyl sulfoxide. AN - 77832963; 3681702 AB - The effect of dimethyl sulfoxide (DMSO) on cholesterol-induced atherosclerosis in the rabbit was investigated. Two groups of rabbits were studied: a Control group which received regular chow and an Experimental group which received an atherogenic diet containing 1% cholesterol. DMSO was either omitted or added to the drinking water of both groups in amounts of 2, 4, 5 and 6%. After 3 months all animals were autopsied; the thoracic aorta was examined for atheromatous lesions and the abdominal aorta assayed for total cholesterol content. As expected the thoracic aortas of all rabbits in the Control group were free of atheromatous lesions. With the exception of one rabbit in the Experimental group, all rabbits on the atherogenic diet which did not receive DMSO had extensive aortic lesions covering 82 +/- 5% of the surface area of the thoracic aorta. Aortic lesions were inhibited by about 50% in rabbits on 2% (dose, 1.5 g/kg) DMSO and virtually absent in the majority of rabbits on 4 (dose, 3.5 g/kg), 5 (dose, 5.5 g/kg) and 6% (dose, 9.1 g/kg) DMSO. The food intake of rabbits on the atherogenic diet was not suppressed by DMSO. Changes in the cholesterol content of the abdominal aortas paralleled the presence or absence of lesions in the thoracic aorta. Blood cholesterol levels were greatly elevated in all rabbits on the atherogenic diet and not lowered by DMSO. In conclusion, cholesterol induced atherosclerosis in the rabbit was inhibited by DMSO. This action of DMSO was independent of the hypercholesterolemia and not due to a suppression of food intake. DMSO may provide a useful probe for investigating the underlying mechanism(s) in the development of cholesterol induced atherosclerosis. JF - The Journal of pharmacology and experimental therapeutics AU - Debons, A F AU - Fani, K AU - Jimenez, F A AU - Maayan, M L AD - Nuclear Medicine Service, Veterans Administration, Medical Center, Brooklyn, New York. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 745 EP - 757 VL - 243 IS - 2 SN - 0022-3565, 0022-3565 KW - Triglycerides KW - 0 KW - Cholesterol KW - 97C5T2UQ7J KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Eating -- drug effects KW - Triglycerides -- blood KW - Animals KW - Liver -- pathology KW - Drinking -- drug effects KW - Body Weight -- drug effects KW - Aorta -- analysis KW - Aorta -- pathology KW - Rabbits KW - Male KW - Aorta -- ultrastructure KW - Dimethyl Sulfoxide -- pharmacology KW - Dimethyl Sulfoxide -- toxicity KW - Cholesterol -- analysis KW - Cholesterol -- toxicity KW - Arteriosclerosis -- prevention & control KW - Arteriosclerosis -- pathology KW - Arteriosclerosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77832963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+cholesterol-induced+atherosclerosis+in+rabbits+by+dimethyl+sulfoxide.&rft.au=Debons%2C+A+F%3BFani%2C+K%3BJimenez%2C+F+A%3BMaayan%2C+M+L&rft.aulast=Debons&rft.aufirst=A&rft.date=1987-11-01&rft.volume=243&rft.issue=2&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vibrio vulnificus bacteremia with endocarditis. AN - 77830197; 3686154 JF - Southern medical journal AU - Truwit, J D AU - Badesch, D B AU - Savage, A M AU - Shelton, M AD - Medical Service, Veterans Administration Medical Center, Nashville, Tenn. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1457 EP - 1459 VL - 80 IS - 11 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Hepatitis, Alcoholic -- complications KW - Humans KW - Adult KW - Male KW - Vibrio -- isolation & purification KW - Endocarditis, Bacterial -- etiology KW - Endocarditis, Bacterial -- microbiology KW - Vibrio Infections -- microbiology KW - Sepsis -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77830197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Vibrio+vulnificus+bacteremia+with+endocarditis.&rft.au=Truwit%2C+J+D%3BBadesch%2C+D+B%3BSavage%2C+A+M%3BShelton%2C+M&rft.aulast=Truwit&rft.aufirst=J&rft.date=1987-11-01&rft.volume=80&rft.issue=11&rft.spage=1457&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-21 N1 - Date created - 1987-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term oral administration of memory-enhancing doses of tacrine in mice: a study of potential toxicity and side effects. AN - 77827345; 3680887 AB - Recently, tacrine (1, 2, 3, 4-tetrahydro-9-aminoacridine; THA; TAC) has received international attention as an oral agent capable of relieving some of the cognitive symptoms accompanying Alzheimer's disease (AD). When given acutely and parenterally (by injection), tacrine has also enhanced memory retention in animals and man. This study evaluates the clinical potential of this agent by assessing toxicity and major side effects of a memory-enhancing dose of tacrine in mice. Groups of mice received either tacrine or vehicle (placebo) orally for 4 to 6 months. A lack of toxicity after this prolonged treatment with TAC was indicated by: (a) no significant impairment on a battery of behavioral toxicity tests; (b) improved memory retention; (c) a significant but only slight elevation of ornithine transcarbamylase activity in blood serum; (d) no abnormality as revealed with light microscopy of liver tissue; and (e) no gross organ pathology in visceral organs. JF - Journal of gerontology AU - Fitten, L J AU - Flood, J F AU - Baxter, C F AU - Tachiki, K H AU - Perryman, K AD - Veterans Administration Medical Center, Sepulveda, CA. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 681 EP - 685 VL - 42 IS - 6 SN - 0022-1422, 0022-1422 KW - Aminoacridines KW - 0 KW - Tacrine KW - 4VX7YNB537 KW - Ornithine Carbamoyltransferase KW - EC 2.1.3.3 KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Behavior, Animal -- drug effects KW - Animals KW - Liver -- pathology KW - Liver -- drug effects KW - Drinking -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Time Factors KW - Ornithine Carbamoyltransferase -- blood KW - Male KW - Tacrine -- toxicity KW - Memory -- drug effects KW - Tacrine -- administration & dosage KW - Aminoacridines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77827345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gerontology&rft.atitle=Long-term+oral+administration+of+memory-enhancing+doses+of+tacrine+in+mice%3A+a+study+of+potential+toxicity+and+side+effects.&rft.au=Fitten%2C+L+J%3BFlood%2C+J+F%3BBaxter%2C+C+F%3BTachiki%2C+K+H%3BPerryman%2C+K&rft.aulast=Fitten&rft.aufirst=L&rft.date=1987-11-01&rft.volume=42&rft.issue=6&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Journal+of+gerontology&rft.issn=00221422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-30 N1 - Date created - 1987-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Predicting attendance at follow-up evaluations in alcoholism treatment outcome research. AN - 77816907; 2824932 AB - The potential utility of an early-warning system involving the use of attendance at scheduled clinical appointments to predict attrition of research subjects from follow-up evaluations was investigated. Subjects (N = 92) discharged from an inpatient alcoholism treatment program into a treatment outcome study were monitored on their aftercare attendance for 1 year postdischarge. Attendance at clinical aftercare sessions during the follow-up year was correlated significantly with attendance at the research project's quarterly follow-up evaluations (p less than .001) and with total number of research evaluations completed (p less than .001). Number of weeks spent in aftercare before dropping out also improved prediction of attendance or nonattendance at quarterly follow-up evaluations during the first 6 months postdischarge (p less than .01). The findings suggest that monitoring attendance at clinical services may be a useful step in minimizing attrition of research subjects from follow-up evaluations. JF - Journal of studies on alcohol AU - Gilbert, F S AU - Maxwell, P J AD - Sepulveda Veterans Administration Medical Center, Psychology Service, California 91343. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 569 EP - 573 VL - 48 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - MMPI KW - Patient Dropouts -- psychology KW - Follow-Up Studies KW - Aftercare -- psychology KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77816907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Predicting+attendance+at+follow-up+evaluations+in+alcoholism+treatment+outcome+research.&rft.au=Gilbert%2C+F+S%3BMaxwell%2C+P+J&rft.aulast=Gilbert&rft.aufirst=F&rft.date=1987-11-01&rft.volume=48&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-14 N1 - Date created - 1988-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Polyamines mediate uncontrolled calcium entry and cell damage in rat heart in the calcium paradox. AN - 77812997; 3119663 AB - Brief perfusion of heart with calcium-free medium renders myocardial cells calcium-sensitive so that readmission of calcium results in uncontrolled Ca2+ entry and acute massive cell injury (calcium paradox). We investigated the hypothesis that polyamines may be involved in the mediation of abnormal Ca2+ influx and cell damage in the calcium paradox. The isolated perfused rat heart was used for these studies. Calcium-free perfusion promptly (less than 5 min) decreased the levels of polyamines and the activity of their rate-regulating synthetic enzyme, ornithine decarboxylase (ODC), and calcium reperfusion abruptly (less than 15-180 s) increased these components. alpha-Difluoromethylornithine (DFMO), a specific suicide inhibitor of ODC, suppressed the calcium reperfusion-induced increase in polyamines and the concomitant increase in myocardial cellular 45Ca influx, loss of contractility, release of cytosolic enzymes, myoglobin, and protein, and structural lesions. Putrescine, the product of ODC activity, nullified DFMO inhibition and restored the calcium reperfusion-induced increment in polyamines and the full expression of the calcium paradox. Putrescine itself enhanced the reperfusion-evoked release of myoglobin and protein in the absence of DFMO. Hypothermia blocked the changes in heart ODC and polyamines induced by calcium-free perfusion and calcium reperfusion and prevented the calcium paradox. These results indicate that rapid Ca2+-directed changes in ODC activity and polyamine levels are essential for triggering excessive transsarcolemmal transport of Ca2+ and explosive myocardial cell injury in the calcium paradox. JF - The Journal of clinical investigation AU - Koenig, H AU - Goldstone, A D AU - Trout, J J AU - Lu, C Y AD - Neurology Service, Veterans Administration Lakeside Medical Center, Chicago, Illinois 60611. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1322 EP - 1331 VL - 80 IS - 5 SN - 0021-9738, 0021-9738 KW - Myoglobin KW - 0 KW - Polyamines KW - Spermine KW - 2FZ7Y3VOQX KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Calcium KW - SY7Q814VUP KW - Spermidine KW - U87FK77H25 KW - Putrescine KW - V10TVZ52E4 KW - Eflornithine KW - ZQN1G5V6SR KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Spermidine -- physiology KW - Perfusion KW - Putrescine -- physiology KW - Myocardium -- pathology KW - Eflornithine -- pharmacology KW - Spermine -- physiology KW - Rats, Inbred Strains KW - Rats KW - Ornithine Decarboxylase -- metabolism KW - Myocardial Contraction KW - Myoglobin -- metabolism KW - Microscopy, Electron KW - Hypothermia, Induced KW - Female KW - Calcium -- metabolism KW - Calcium -- toxicity KW - Heart Diseases -- chemically induced KW - Calcium -- administration & dosage KW - Polyamines -- physiology KW - Heart Diseases -- physiopathology KW - Heart Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77812997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Polyamines+mediate+uncontrolled+calcium+entry+and+cell+damage+in+rat+heart+in+the+calcium+paradox.&rft.au=Koenig%2C+H%3BGoldstone%2C+A+D%3BTrout%2C+J+J%3BLu%2C+C+Y&rft.aulast=Koenig&rft.aufirst=H&rft.date=1987-11-01&rft.volume=80&rft.issue=5&rft.spage=1322&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-23 N1 - Date created - 1987-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1966 Aug 6;211(5049):646-7 [5968741] Biochem J. 1986 Mar 1;234(2):249-62 [3087344] Life Sci. 1978 Feb;22(7):571-6 [625198] J Mol Cell Cardiol. 1978 Nov;10(11):991-1002 [722803] Biochem Biophys Res Commun. 1978 Dec 14;85(3):1156-64 [83867] Annu Rev Physiol. 1979;41:473-84 [373601] Am J Physiol. 1979 Dec;237(6):H713-9 [517670] Proc Natl Acad Sci U S A. 1980 Feb;77(2):995-9 [6102386] Life Sci. 1980 Mar 3;26(9):689-98 [7366339] Circ Res. 1981 Jan;48(1):17-24 [7438344] Anal Biochem. 1981 May 15;113(2):352-5 [7283139] Proc Natl Acad Sci U S A. 1981 Sep;78(9):5665-8 [6946505] J Mol Cell Cardiol. 1981 Oct;13(10):867-80 [6273592] Differentiation. 1981;19(1):1-20 [6173280] Circ Res. 1982 Aug;51(2):117-30 [7094224] Circ Res. 1982 Sep;51(3):363-70 [6811156] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] Lab Invest. 1983 Feb;48(2):156-61 [6296540] J Mol Cell Cardiol. 1983 Jun;15(6):393-411 [6876188] Nature. 1983 Oct 6-12;305(5934):530-4 [6413866] Am J Physiol. 1983 Oct;245(4):H535-52 [6353942] Proc Natl Acad Sci U S A. 1983 Dec;80(23):7210-4 [6580640] J Cell Physiol. 1984 Jan;118(1):39-44 [6690450] Eur Heart J. 1983 Dec;4 Suppl H:29-41 [6662131] Eur Heart J. 1983 Dec;4 Suppl H:51-6 [6662134] Eur Heart J. 1983 Dec;4 Suppl H:73-9 [6319144] Circ Res. 1984 Mar;54(3):217-26 [6321053] Circ Res. 1984 Aug;55(2):227-37 [6744532] Annu Rev Biochem. 1984;53:749-90 [6206782] J Mol Cell Cardiol. 1984 Sep;16(9):783-93 [6092650] Am J Physiol. 1984 Nov;247(5 Pt 2):H874-9 [6093599] Diabetes. 1985 Mar;34(3):287-90 [3882496] Biochem Biophys Res Commun. 1985 Jan 31;126(2):901-4 [3977893] J Mol Cell Cardiol. 1985 Aug;17(8):733-45 [3900425] Drug Metab Rev. 1985;16(1-2):1-88 [3905315] Biochem Biophys Res Commun. 1985 Dec 17;133(2):563-73 [2867766] J Mol Cell Cardiol. 1986 Jan;18(1):3-11 [3005596] J Mol Cell Cardiol. 1986 Mar;18(3):241-54 [2420998] J Mol Cell Cardiol. 1975 Dec;7(12):917-28 [1206720] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stimulation of suppressor cells in the bone marrow and spleens of high dose cyclophosphamide-treated C57Bl/6 mice. AN - 81065280; 2959374 AB - Systemic administration of a single dose (300 mg/kg) of cyclophosphamide (Cy) induced the appearance of a population of suppressor cells in the bone marrow and spleens of mice. Suppressor cells were assayed by their capacity to inhibit the concanavalin A (Con A) blastogenesis or the mixed-lymphocyte response of normal C57Bl/6 spleen cells. Cy-induced bone marrow (Cy-BM) suppressor cells were present as early as 4 days following Cy therapy and their activity gradually decreased over the next 2 weeks. Cy-induced splenic (Cy-Sp) suppressor cells were maximally present on Days 6 through 10 following Cy therapy. Studies were performed to characterize the suppressor cells of bone marrow obtained 4 days after Cy treatment and of normal bone marrow (N-BM). Some suppressor activity was present in normal bone marrow. N-BM suppressor cells resembled cells of the monocyte/macrophage lineage in that they were slightly adherent to Sephadex G-10, sensitive to L-leucine methyl ester (LME), and insensitive to treatment either with anti-T-cell antibody and complement or with anti-immunoglobulin antibody and complement. Their suppressive activity was abrogated by incubation with either indomethacin or catalase. Cy-BM suppressor cells were also resistant to treatment with anti-T-cell and anti-immunoglobulin antibody and complement but were not adherent to Sephadex G-10 and not sensitive to LME. Their suppressive activity was partially eliminated by indomethacin alone or in combination with catalase. We conclude that Cy chemotherapy induces the appearance of a population of immune suppressive cells and that these cells appear first in the bone marrow and subsequently in the spleen. JF - Cellular immunology AU - Nikcevich, D A AU - Duffie, G P AU - Young, M R AU - Ellis, N K AU - Kaufman, G E AU - Wepsic, H T AD - Department of Research Services, Edward J. Hines, Jr., Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 349 EP - 359 VL - 109 IS - 2 SN - 0008-8749, 0008-8749 KW - Cyclophosphamide KW - 8N3DW7272P KW - Complement System Proteins KW - 9007-36-7 KW - Catalase KW - EC 1.11.1.6 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Lymphocyte Activation -- drug effects KW - Animals KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - T-Lymphocytes -- drug effects KW - Complement System Proteins -- immunology KW - Mice, Inbred BALB C KW - Catalase -- pharmacology KW - T-Lymphocytes -- immunology KW - Male KW - Indomethacin -- pharmacology KW - Spleen -- immunology KW - Spleen -- drug effects KW - Bone Marrow -- drug effects KW - Bone Marrow -- immunology KW - T-Lymphocytes, Regulatory -- immunology KW - Cyclophosphamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81065280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Stimulation+of+suppressor+cells+in+the+bone+marrow+and+spleens+of+high+dose+cyclophosphamide-treated+C57Bl%2F6+mice.&rft.au=Nikcevich%2C+D+A%3BDuffie%2C+G+P%3BYoung%2C+M+R%3BEllis%2C+N+K%3BKaufman%2C+G+E%3BWepsic%2C+H+T&rft.aulast=Nikcevich&rft.aufirst=D&rft.date=1987-10-15&rft.volume=109&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-16 N1 - Date created - 1987-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of Delayed Auditory Feedback on Acquired Stuttering Following Head Injury AN - 85329101; llba-8802140 AB - The effects of delayed auditory feedback (DAF) was examined in three cases of acquired stuttering following head injury. To determine the effects of DAF on stuttering behavior a multiple baseline design across three speaking tasks was employed. All Ss reduced stuttering with application of DAF. Stuttering behavior on untreated tasks continuing in baseline was not affected by DAF. When treatment was applied to the untreated tasks, stuttering events decreased for all three Ss. Results indicate DAF has potential as a treatment procedure with cases of acquired stuttering in a way similar to cases of developmental stuttering. 3 Figures, 22 References. HA JF - Journal of Fluency Disorders AU - Marshall, Robert C AU - Neuburger, Sandra I AD - Veterans Administration Medical Center, 3710 SW Veterans Hospital Rd Portland OR 97207 Y1 - 1987/10// PY - 1987 DA - Oct 1987 SP - 355 EP - 365 VL - 12 IS - 5 SN - 0094-730X, 0094-730X KW - acquired stuttering KW - delayed auditory feedback treatment KW - adult head-injury stutterers KW - *Stuttering (st9) KW - *Delayed Auditory Feedback (de5) KW - *Speech Therapy (sp13) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85329101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fluency+Disorders&rft.atitle=Effects+of+Delayed+Auditory+Feedback+on+Acquired+Stuttering+Following+Head+Injury&rft.au=Marshall%2C+Robert+C%3BNeuburger%2C+Sandra+I&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1987-10-01&rft.volume=12&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fluency+Disorders&rft.issn=0094730X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JFDID8 N1 - SubjectsTermNotLitGenreText - *Stuttering (st9); *Speech Therapy (sp13); *Delayed Auditory Feedback (de5) ER - TY - JOUR T1 - The effect of temporal dispersion on compound action potential area in human peripheral nerve. AN - 85267338; pmid-3683446 AB - In 32 ulnar nerves of healthy volunteers, the mean area of the compound muscle action potential recorded over abductor digiti minimi was reduced by 7.4% when comparing above-elbow with wrist stimulation and by 1.9% when comparing above-elbow with below-elbow stimulation. In 20 of these nerves, the mean area of the compound nerve action potential (CNAP) recorded over the fifth digit was reduced by 36% when comparing above-elbow with wrist stimulation. Area reduction of the compound action potential, especially of the CNAP, appears to be a characteristic effect of temporal dispersion in peripheral nerve when utilizing the bipolar recording technique routinely employed in clinical neurophysiology. A thorough understanding of the effects caused by temporal dispersion and of their quantitative limits in normal peripheral nerve is important for the proper interpretation of nerve conduction studies. JF - Muscle & Nerve AU - Olney, R K AU - Budingen, H J AU - Miller, R G AD - Department of Neurology, Veterans Administration Medical Center, Portland, Oregon. PY - 1987 SP - 728 EP - 733 VL - 10 IS - 8 SN - 0148-639X, 0148-639X KW - Peripheral Nerves KW - Nerve Compression Syndromes KW - Evoked Potentials KW - Human KW - Adult KW - Muscles KW - Middle Age KW - Aged KW - Electric Stimulation KW - Sensation KW - Motor Neurons KW - Ulnar Nerve KW - Neural Conduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85267338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+Nerve&rft.atitle=The+effect+of+temporal+dispersion+on+compound+action+potential+area+in+human+peripheral+nerve.&rft.au=Olney%2C+R+K%3BBudingen%2C+H+J%3BMiller%2C+R+G&rft.aulast=Olney&rft.aufirst=R&rft.date=1987-10-01&rft.volume=10&rft.issue=8&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+Nerve&rft.issn=0148639X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Apraxia in a patient with atypical cerebral dominance. AN - 85209867; pmid-3663384 AB - Liepmann postulated that the left hemisphere of right-handed persons contains the "movement formulas" that control purposeful skilled movements of the limbs on both sides of the body. Accordingly, in right-handers apraxia should follow damage to the left hemisphere, whereas right hemisphere damage should not lead to apraxia. Although this is generally true, we recently examined a right-handed man who after a right hemispheric stroke became aphasic and apraxic with his nonparalyzed right hand. Our observations suggest that the right hemisphere of this right-handed man made a critical contribution to the planning and execution of skilled movements. This case provides evidence that right-handers should not be considered a homogeneous group in terms of cerebral motor dominance and that contrary to Liepmann's postulate, hemispheric dominance for the control of skilled movements does not entirely determine handedness. JF - Brain and Cognition AU - Rapcsak, S Z AU - Gonzalez Rothi L J AU - Heilman, K M AD - Veterans Administration Medical Center, Gainesville, FL. PY - 1987 SP - 450 EP - 463 VL - 6 IS - 4 SN - 0278-2626, 0278-2626 KW - Hemiplegia KW - Support, U.S. Gov't, P.H.S. KW - Cerebral Infarction KW - Human KW - Tomography, X-Ray Computed KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Psychomotor Performance KW - Case Report KW - Apraxias KW - Neuropsychological Tests KW - Gestures KW - Male KW - Dominance, Cerebral UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85209867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Cognition&rft.atitle=Apraxia+in+a+patient+with+atypical+cerebral+dominance.&rft.au=Rapcsak%2C+S+Z%3BGonzalez+Rothi+L+J%3BHeilman%2C+K+M&rft.aulast=Rapcsak&rft.aufirst=S&rft.date=1987-10-01&rft.volume=6&rft.issue=4&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Brain+and+Cognition&rft.issn=02782626&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Fracture, separation, and aspiration of tracheostomy tubes: management with a new technique. AN - 85204128; pmid-3120117 JF - Otolaryngology--Head and Neck Surgery AU - Slotnick, D B AU - Urken, M L AU - Sacks, S H AU - Lawson, W AD - Division of Otolaryngology-Head and Neck Surgery, Bronx Veterans Administration Medical Center, NY. PY - 1987 SP - 423 EP - 427 VL - 97 IS - 4 SN - 0194-5998, 0194-5998 KW - Foreign-Body Migration KW - Human KW - Tracheostomy KW - Aged KW - Middle Age KW - Case Report KW - Equipment Failure KW - Foreign Bodies KW - Male KW - Bronchoscopes KW - Bronchi KW - Trachea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85204128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Fracture%2C+separation%2C+and+aspiration+of+tracheostomy+tubes%3A+management+with+a+new+technique.&rft.au=Slotnick%2C+D+B%3BUrken%2C+M+L%3BSacks%2C+S+H%3BLawson%2C+W&rft.aulast=Slotnick&rft.aufirst=D&rft.date=1987-10-01&rft.volume=97&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Endoscopic techniques and complications in variceal sclerotherapy. AN - 85202938; pmid-3316372 AB - Increasing interest in esophageal variceal sclerotherapy (EVS) for bleeding varices is attested to by hundreds of recent articles on the subject. Hardly a medical journal is published that does not contain a report or editorial opinion about the procedure. Indeed, enthusiastic battle lines have been drawn by those who employ the procedure and skeptics who are awaiting proof of its efficacy. On the sidelines is a fairly large group of medical "fence-sitters," whose agnostic critiques keep the entire question lively and worth dissecting. EVS is not without complications, but it is not very difficult to perform. It can control active variceal hemorrhage and prevent rebleeding in stabilized patients. Its effect on survival seems to be related to the underlying liver disease, the endoscopist's ability to obliterate the varices, and treatment-related morbidity and mortality. Prophylactic EVS may be helpful in carefully selected patients. We review current controversies about EVS and offer technical suggestions to improve efficacy and lower EVS-related morbidity and mortality. JF - Journal of Clinical Gastroenterology AU - Sanowski, R A AU - Waring, J P AD - Gastroenterology Section, Veterans Administration Medical Center, Phoenix, Arizona 85012. PY - 1987 SP - 504 EP - 513 VL - 9 IS - 5 SN - 0192-0790, 0192-0790 KW - Human KW - Risk Factors KW - Esophageal and Gastric Varices KW - Sclerosing Solutions KW - Esophagoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85202938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Endoscopic+techniques+and+complications+in+variceal+sclerotherapy.&rft.au=Sanowski%2C+R+A%3BWaring%2C+J+P&rft.aulast=Sanowski&rft.aufirst=R&rft.date=1987-10-01&rft.volume=9&rft.issue=5&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Ascitic fluid bilirubin concentration as a key to choleperitoneum. AN - 85201897; pmid-3680904 AB - Total bilirubin concentration was measured in the ascitic fluid and serum of 65 patients with various types of ascites to determine the normal range of these parameters. The mean (+/- SD) ascitic fluid bilirubin was 0.7 +/- 0.8 mg/dl, and the mean ascitic fluid/serum bilirubin ratio was 0.38 +/- 0.44. Subsequently, I recognized choleperitoneum in a patient with bile-stained ascites preoperatively, because the ascitic fluid bilirubin was 18.5 mg/dl and the ratio was 7.1. Laparotomy documented a ruptured gallbladder. An ascitic fluid bilirubin concentration greater than 6 mg/dl with an ascitic fluid/serum bilirubin ratio greater than 1.0 appears to be characteristic of choleperitoneum. JF - Journal of Clinical Gastroenterology AU - Runyon, B A AD - Department of Medicine, Long Beach Veterans Administration Medical Center, California. PY - 1987 SP - 543 EP - 545 VL - 9 IS - 5 SN - 0192-0790, 0192-0790 KW - Bacterial Infections KW - Gallbladder Diseases KW - Diagnosis, Differential KW - Ascitic Fluid KW - Human KW - Peritonitis KW - Aged KW - Bilirubin KW - Case Report KW - Rupture, Spontaneous KW - Intestinal Perforation KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Ascitic+fluid+bilirubin+concentration+as+a+key+to+choleperitoneum.&rft.au=Runyon%2C+B+A&rft.aulast=Runyon&rft.aufirst=B&rft.date=1987-10-01&rft.volume=9&rft.issue=5&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Three-phase radionuclide bone scanning in evaluation of local radiation injury. A case report. AN - 81112196; 3677524 AB - The management of local radiation injuries is influenced by the degree of vascular compromise within the skin and underlying tissues. Other authors have used thermography and angiography in assessing the blood flow to radiation damaged tissues. This report describes the use of radionuclide imaging in the evaluation of a patient who developed necrosis of his distal digits following a radiation accident. In addition to determining the vascular status of the hands, imaging helped indicate an appropriate level for amputation. JF - Clinical nuclear medicine AU - Mettler, F A AU - Monsein, L AU - Davis, M AU - Rosenberg, R AU - Kelsey, C AU - Listrom, M AD - Department of Radiology, Albuquerque Veterans Administration Medical Center, New Mexico 87108. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 805 EP - 808 VL - 12 IS - 10 SN - 0363-9762, 0363-9762 KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Osteomyelitis -- diagnostic imaging KW - Adult KW - Radiodermatitis -- diagnostic imaging KW - Male KW - Radionuclide Imaging KW - Occupational Diseases -- diagnostic imaging KW - Radiation Injuries -- diagnostic imaging KW - Osteoradionecrosis -- diagnostic imaging KW - Radiography KW - Bone and Bones -- radiation effects KW - Accidents, Occupational KW - Fingers -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81112196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=Three-phase+radionuclide+bone+scanning+in+evaluation+of+local+radiation+injury.+A+case+report.&rft.au=Mettler%2C+F+A%3BMonsein%2C+L%3BDavis%2C+M%3BRosenberg%2C+R%3BKelsey%2C+C%3BListrom%2C+M&rft.aulast=Mettler&rft.aufirst=F&rft.date=1987-10-01&rft.volume=12&rft.issue=10&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-07 N1 - Date created - 1988-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemical monitoring of disulfiram compliance: a study of alcoholic outpatients. AN - 81100904; 3314565 AB - Poor compliance with disulfiram (Antabuse) therapy may reduce its efficacy in the treatment of alcoholism. This study was designed to examine two questions: (a) Could use of a chemical test for disulfiram ingestion be used clinically to improve disulfiram compliance and if so, (b) could improved disulfiram compliance contribute to improved compliance with other aspects of treatment? The results suggest that disulfiram compliance rates can be increased by clinical use of chemical monitoring data; however in this sample increased compliance with disulfiram did not correlate with improvements in other aspects of treatment compliance. JF - Alcoholism, clinical and experimental research AU - Kofoed, L L AD - Psychiatry Service, Portland Veterans Administration Medical Center, Oregon. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 481 EP - 485 VL - 11 IS - 5 SN - 0145-6008, 0145-6008 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Random Allocation KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Breath Tests KW - Ambulatory Care KW - Disulfiram -- therapeutic use KW - Patient Compliance KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81100904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Chemical+monitoring+of+disulfiram+compliance%3A+a+study+of+alcoholic+outpatients.&rft.au=Kofoed%2C+L+L&rft.aulast=Kofoed&rft.aufirst=L&rft.date=1987-10-01&rft.volume=11&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholics Anonymous: affiliation processes and effectiveness as treatment. AN - 81100862; 3314553 AB - Recent findings from the empirical literature on Alcoholics Anonymous (AA) suggest that no clear exclusionary criteria for this organization exist, except that alcohol-dependent individuals who become nonproblem drinkers appear to be less likely to affiliate with or maintain involvement in AA. Of those alcoholics who become long term, active AA members, about 40 to 50% enjoy several years of total abstinence, with about 60 to 68% improving to some extent, drinking less or not at all during their participation. Those who combine AA with other forms of treatment seem to do as well as or better than those who go to AA alone. More active AA participants do as well as or better than those who participate less actively. Compared to professionally treated alcoholics, AA members seem to achieve abstinence at a higher rate. Consideration is given to the apparent unsuitability of AA for problem drinkers who choose the goal of nonproblem drinking. JF - Alcoholism, clinical and experimental research AU - Emrick, C D AD - Veterans Administration Medical Center, Denver, CO 80220. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 416 EP - 423 VL - 11 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Prognosis KW - Alcoholism -- therapy KW - Alcoholics Anonymous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81100862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcoholics+Anonymous%3A+affiliation+processes+and+effectiveness+as+treatment.&rft.au=Emrick%2C+C+D&rft.aulast=Emrick&rft.aufirst=C&rft.date=1987-10-01&rft.volume=11&rft.issue=5&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Alcohol Clin Exp Res 1988 Feb;12(1):29 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Varicella in hospital personnel: a challenge for the infection control practitioner. AN - 81091221; 3674538 AB - Five unrelated cases of chickenpox (varicella) occurred in a 1-month period involving one physician, two house staff members, one medical student, and a nursing assistant at a large Veterans Administration medical center. This required immediate identification of susceptible employees and patients to prevent transmission to other personnel and patients. Negative history is not a reliable predictor of susceptibility. Of the fifty contacts reporting negative histories, only five persons (10%) were actually negative by antibody testing. No secondary cases of varicella occurred. These incidents suggested that more rapid prescreening of key hospital personnel with negative histories who have direct patient contact might be helpful in identifying susceptible employees in the future. JF - American journal of infection control AU - Haiduven-Griffiths, D AU - Fecko, H AD - Infectious Diseases Section (III), Miami Veterans Administration Medical Center, FL. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 207 EP - 211 VL - 15 IS - 5 SN - 0196-6553, 0196-6553 KW - Index Medicus KW - Hospital Bed Capacity, 500 and over KW - Humans KW - Adult KW - Florida KW - Male KW - Female KW - Personnel, Hospital KW - Cross Infection -- transmission KW - Chickenpox -- transmission KW - Occupational Diseases -- prevention & control KW - Chickenpox -- prevention & control KW - Cross Infection -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81091221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Varicella+in+hospital+personnel%3A+a+challenge+for+the+infection+control+practitioner.&rft.au=Haiduven-Griffiths%2C+D%3BFecko%2C+H&rft.aulast=Haiduven-Griffiths&rft.aufirst=D&rft.date=1987-10-01&rft.volume=15&rft.issue=5&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=01966553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Somatostatin analogs as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer. AN - 81088307; 2890164 AB - The combination of a long-acting delivery system for the agonist [D-Trp6]luteinizing hormone-releasing hormone ([D-Trp6]LH-RH) with modern somatostatin analogs was studied in the Dunning R-3327H rat prostate cancer model. Microcapsules of [D-Trp6]LH-RH releasing 25 micrograms/day were injected once a month. In the first experiment the adjunct was the somatostatin analog D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 (RC-121), administered at a dose of 2.5 micrograms twice a day, and the therapy was continued for 70 days. Tumor volume was significantly decreased by [D-Trp6]LH-RH microcapsules or RC-121 given alone. The combination of microcapsules and analog RC-121 caused a greater inhibition of tumor growth than the single agents. Similar effects were seen when the percent increase in the tumor volume was examined. The inhibition of tumor growth caused by the [D-Trp6]LH-RH microcapsules was greater than that caused by RC-121. The combination of the two agents was again the most effective, resulting in the smallest increase in tumor volume. Tumor weights were much lower in the groups treated with microcapsules or RC-121 alone than in controls. The lowest tumor weights were obtained in the group that received the combination of [D-Trp6]LH-RH microcapsules and RC-121. Similar results were obtained in the second experiment, in which the animals were treated for a period of 83 days with microcapsules containing the somatostatin analog D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160) that released 5 micrograms/day and were injected twice a month alone or in combination with microcapsules of [D-Trp6]LH-RH. Microcapsules of analog RC-160 given alone significantly decreased tumor growth as measured by the final tumor volume, the percentage change from the initial tumor volume, and the reduction in tumor weight. The inhibition of tumor growth induced by [D-Trp6]LH-RH microcapsules was greater than that caused by RC-160. The most striking decrease in tumor weight and volume was obtained in animals treated with microcapsules of [D-Trp6]LH-RH combined with the delayed delivery system for RC-160. The overall response to the combination therapy could reflect the inhibition by somatostatin analogs of the proliferation of prostate cancer cells through a decrease in growth hormone and prolactin release and interference with endogenous growth factors, in addition to the main effect, which is the suppression by [D-Trp6]LH-RH of the growth of androgen-dependent tumor cells. Our results indicate that somatostatin analogs enhance the inhibitory effects of [D-Trp6]LH-RH on the growth of prostate tumors. The administration of somatostatin analogs in combination with microcapsules of [D-Trp6]LH-RH might improve clinical response in patients with advanced prostate carcinoma. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Schally, A V AU - Redding, T W AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70146. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 7275 EP - 7279 VL - 84 IS - 20 SN - 0027-8424, 0027-8424 KW - Antineoplastic Agents KW - 0 KW - Capsules KW - vapreotide KW - 2PK59M9GFF KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Somatostatin KW - 51110-01-1 KW - Triptorelin Pamoate KW - 57773-63-4 KW - RC 121 KW - 99660-13-6 KW - Octreotide KW - RWM8CCW8GP KW - Index Medicus KW - Rats KW - Prostate -- drug effects KW - Animals KW - Drug Compounding KW - Prostate -- pathology KW - Drug Synergism KW - Male KW - Organ Size -- drug effects KW - Octreotide -- analogs & derivatives KW - Antineoplastic Agents -- administration & dosage KW - Somatostatin -- therapeutic use KW - Somatostatin -- analogs & derivatives KW - Gonadotropin-Releasing Hormone -- administration & dosage KW - Prostatic Neoplasms -- drug therapy KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Adenocarcinoma -- pathology KW - Somatostatin -- pharmacology KW - Prostatic Neoplasms -- pathology KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - Somatostatin -- administration & dosage KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Gonadotropin-Releasing Hormone -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81088307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Somatostatin+analogs+as+adjuncts+to+agonists+of+luteinizing+hormone-releasing+hormone+in+the+treatment+of+experimental+prostate+cancer.&rft.au=Schally%2C+A+V%3BRedding%2C+T+W&rft.aulast=Schally&rft.aufirst=A&rft.date=1987-10-01&rft.volume=84&rft.issue=20&rft.spage=7275&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Invest Urol. 1977 May;14(6):492-5 [15955] Urology. 1980 Sep;16(3):257-60 [7423702] Proc Natl Acad Sci U S A. 1980 Oct;77(10):5989-92 [6969400] Cancer Res. 1981 Dec;41(12 Pt 1):5070-5 [7307008] Endocrinology. 1982 Oct;111(4):1394-6 [6126353] Proc Natl Acad Sci U S A. 1982 Nov;79(22):7014-8 [6757925] Life Sci. 1983 Jan 31;32(5):487-93 [6296591] Science. 1983 Jul 15;221(4607):275-7 [6304883] Nature. 1983 Jul 7-13;304(5921):35-9 [6306471] Nature. 1984 Feb 9-15;307(5951):521-7 [6320011] Proc Natl Acad Sci U S A. 1984 Feb;81(3):935-9 [6583688] Cell. 1984 May;37(1):9-20 [6373015] J Endocrinol. 1984 Oct;103(1):1-7 [6384415] Proc Natl Acad Sci U S A. 1984 Sep;81(18):5845-8 [6237365] Prostate. 1984;5(6):589-95 [6494057] J Clin Invest. 1985 Jan;75(1):306-9 [2981251] FEBS Lett. 1985 Jan 7;179(2):252-6 [2857131] Cancer Res. 1985 Jun;45(6):2689-94 [3857121] Prostate. 1985;6(3):269-76 [3857564] Proc Natl Acad Sci U S A. 1985 Apr;82(8):2498-502 [3157990] J Urol. 1985 Jun;133(6):1112-20 [4039764] Nature. 1985 Aug 29-Sep 4;316(6031):823-6 [2993906] Pathol Res Pract. 1985 Jul;180(1):77-80 [3162163] Lancet. 1985 Nov 30;2(8466):1201-5 [2866289] Cancer Res. 1986 Mar;46(3):1015-29 [3002607] Cancer Res. 1986 Mar;46(3):1030-7 [3002608] Endocrinology. 1986 Feb;118(2):888-90 [3943494] Proc Natl Acad Sci U S A. 1986 Mar;83(6):1896-900 [2869490] J Steroid Biochem. 1986 Jan;24(1):147-54 [3486321] Science. 1986 Aug 1;233(4763):551-3 [3726546] Science. 1986 Aug 1;233(4763):571-4 [3523759] Proc Natl Acad Sci U S A. 1986 Nov;83(22):8764-8 [2946045] Prostate. 1986;9(4):327-42 [2947053] Proc Natl Acad Sci U S A. 1987 Feb;84(4):1112-6 [2881296] Proc Soc Exp Biol Med. 1987 May;185(1):69-75 [2883661] Natl Cancer Inst Monogr. 1963 Oct;12:189-99 [14072990] Cancer Res. 1975 Dec;35(12):3698-704 [1192428] Annu Rev Biochem. 1978;47:89-128 [28075] Biol Reprod. 1980 Mar;22(2):351-5 [7378539] Proc Natl Acad Sci U S A. 1980 Sep;77(9):5258-62 [6254071] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Survey on testing criteria and reporting methods for human immunodeficiency virus serologic tests in Veterans Administration Medical Centers. AN - 81070528; 3499416 AB - Guidelines for the indications for use, requirements for consent, and mechanisms for reporting of serologic tests for human immunodeficiency virus (HIV) infection are not standardized. In trying to establish such guidelines for our hospital, we surveyed all Veterans Administration Medical Centers regarding their current approach to testing both patients and employees. Infection control practitioners from 67 hospitals representing 37 states responded. Patients are likely to be tested for diverse reasons, unlikely to be counseled about the test or be required to consent to it, and test results are given no special precautions. Although 66% of the respondents do not use any extra precautions concerning patient confidentiality, 80% utilize more stringent criteria for testing and result-reporting with employees than patients. Thus, while the majority of hospitals maintain that current modes of confidentiality are acceptable for patients, practice suggests that these modes are considered inadequate for employees. JF - Infection control : IC AU - Mottice, S AU - Matsumiya, S AU - Reimer, L AD - Department of Pathology, Salt Lake City Veterans Administration Medical Center, UT 84148. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 407 EP - 411 VL - 8 IS - 10 SN - 0195-9417, 0195-9417 KW - Antibodies, Viral KW - 0 KW - HIV Antibodies KW - Bioethics KW - Index Medicus KW - Nursing KW - AIDS/HIV KW - Health Care and Public Health KW - Veterans Administration Medical Centers KW - Empirical Approach KW - Personnel, Hospital KW - Consent Forms KW - Risk Factors KW - Humans KW - Occupational Diseases -- prevention & control KW - Confidentiality -- legislation & jurisprudence KW - Medical Records, Problem-Oriented KW - Disclosure KW - Hospitals, Veterans KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - HIV -- immunology KW - Mass Screening -- legislation & jurisprudence KW - Acquired Immunodeficiency Syndrome -- immunology KW - Antibodies, Viral -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81070528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+%3A+IC&rft.atitle=Survey+on+testing+criteria+and+reporting+methods+for+human+immunodeficiency+virus+serologic+tests+in+Veterans+Administration+Medical+Centers.&rft.au=Mottice%2C+S%3BMatsumiya%2C+S%3BReimer%2C+L&rft.aulast=Mottice&rft.aufirst=S&rft.date=1987-10-01&rft.volume=8&rft.issue=10&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Infection+control+%3A+IC&rft.issn=01959417&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Myoclonus following sufentanil without EEG seizure activity. AN - 81058750; 2959172 JF - Anesthesiology AU - Bowdle, T A AD - Department of Anesthesiology, Veterans Administration Medical Center, Seattle, Washington 98108. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 593 EP - 595 VL - 67 IS - 4 SN - 0003-3022, 0003-3022 KW - Sufentanil KW - AFE2YW0IIZ KW - Fentanyl KW - UF599785JZ KW - Abridged Index Medicus KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Aged KW - Male KW - Myoclonus -- chemically induced KW - Myoclonus -- diagnosis KW - Fentanyl -- adverse effects KW - Electroencephalography KW - Epilepsies, Myoclonic -- diagnosis KW - Fentanyl -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81058750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Myoclonus+following+sufentanil+without+EEG+seizure+activity.&rft.au=Bowdle%2C+T+A&rft.aulast=Bowdle&rft.aufirst=T&rft.date=1987-10-01&rft.volume=67&rft.issue=4&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-10 N1 - Date created - 1987-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lysophosphatidylcholine augments elastase-induced alveolar epithelial permeability and emphysema in the hamster. AN - 81056498; 3662244 AB - We administered low dose porcine pancreatic elastase (PPE) with and without lysophosphatidylcholine (lysoPC), a naturally occurring constituent of lung lipids with known membrane-perturbing properties, to test the hypothesis that alveolar epithelial solute permeability is a determinant of the severity of elastase-induced emphysema in experimental animals. Four age- and weight-matched groups of hamsters received intratracheal injections of one of the following in a total volume of 0.5 ml TRIS buffered saline: (1) no additions, (2) 4 units PPE, (3) 135 micrograms lysoPC, or (4) 4 units PPE plus 135 micrograms lysoPC. Thirty minutes later the permeability surface area products (PS) of the alveolar epithelium to 14C-sucrose and 125I-dextran 70 were measured in excised, perfused lungs from some animals from each group. The remaining animals were killed at 6 wk, at which time pressure-volume relationships were measured in excised lungs, and the mean linear intercept was determined from sections of fixed lung tissue. Neither PPE nor lysoPC alone caused statistically significant increases in PS for either tracer. The PPE plus lysoPC caused statistically insignificant increases in sucrose PS but approximate tenfold increases in dextran 70 PS, which were highly significant (p less than 0.001). Although focal air-space enlargement was observed in some lungs 6 wk after exposure to PPE, pressure-volume relationships and mean linear intercepts were not significantly different from control values. Lungs previously exposed to lysoPC were indistinguishable from control lungs for all measurements. Severe emphysema was uniformly observed in animals that received PPE in combination with lysoPC; lysoPC had no demonstrable effect upon PPE-induced hydrolysis of native elastin in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Rice, K L AU - Duane, P G AU - Niewoehner, D E AD - Pulmonary Section, Veterans Administration Medical Center, Minneapolis, MN 55417. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 941 EP - 946 VL - 136 IS - 4 SN - 0003-0805, 0003-0805 KW - Lysophosphatidylcholines KW - 0 KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Mesocricetus KW - Pancreas -- enzymology KW - Lung -- pathology KW - Drug Synergism KW - Time Factors KW - Female KW - Epithelium -- drug effects KW - Cricetinae KW - Pancreatic Elastase -- pharmacology KW - Cell Membrane Permeability -- drug effects KW - Pulmonary Emphysema -- pathology KW - Lysophosphatidylcholines -- pharmacology KW - Pulmonary Alveoli -- drug effects KW - Pulmonary Emphysema -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81056498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Lysophosphatidylcholine+augments+elastase-induced+alveolar+epithelial+permeability+and+emphysema+in+the+hamster.&rft.au=Rice%2C+K+L%3BDuane%2C+P+G%3BNiewoehner%2C+D+E&rft.aulast=Rice&rft.aufirst=K&rft.date=1987-10-01&rft.volume=136&rft.issue=4&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Captopril-related (and -induced?) asthma. AN - 81054721; 3310776 AB - A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure. A double-blind challenge with nadolol and captopril decreased FEV1 by 3 and 12%, respectively. This confirmed the history of captopril-related asthma. As angiotensin-converting enzyme seems to play a role in the genesis and metabolism of bronchomotor mediators, this rare form of drug-induced asthma is important for both clinicians and airways pharmacologists. JF - The American review of respiratory disease AU - Popa, V AD - Veterans Administration Outpatient Clinic, University of California at Davis, Sacramento 95823. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 999 EP - 1000 VL - 136 IS - 4 SN - 0003-0805, 0003-0805 KW - Drug Combinations KW - 0 KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - hydrochlorothiazide-triamterene KW - 14124-50-6 KW - Nadolol KW - 42200-33-9 KW - Captopril KW - 9G64RSX1XD KW - Triamterene KW - WS821Z52LQ KW - Abridged Index Medicus KW - Index Medicus KW - Triamterene -- therapeutic use KW - Nadolol -- therapeutic use KW - Hypertension -- complications KW - Drug Therapy, Combination KW - Humans KW - Drug Combinations -- therapeutic use KW - Middle Aged KW - Hydrochlorothiazide -- therapeutic use KW - Forced Expiratory Volume KW - Male KW - Hypertension -- drug therapy KW - Captopril -- adverse effects KW - Asthma -- diagnosis KW - Asthma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Captopril-related+%28and+-induced%3F%29+asthma.&rft.au=Popa%2C+V&rft.aulast=Popa&rft.aufirst=V&rft.date=1987-10-01&rft.volume=136&rft.issue=4&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seasonality of birth and CT findings in schizophrenia. AN - 81054190; 3499180 JF - Biological psychiatry AU - Zipursky, R B AU - Schulz, S C AD - Department of Psychiatry, Veterans Administration Medical Center, Palo Alto, CA 94304. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1288 EP - 1292 VL - 22 IS - 10 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Labor, Obstetric KW - Humans KW - Retrospective Studies KW - Environmental Exposure KW - Cerebral Ventriculography KW - Female KW - Pregnancy KW - Schizophrenia -- etiology KW - Seasons KW - Tomography, X-Ray Computed KW - Schizophrenia -- genetics KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Seasonality+of+birth+and+CT+findings+in+schizophrenia.&rft.au=Zipursky%2C+R+B%3BSchulz%2C+S+C&rft.aulast=Zipursky&rft.aufirst=R&rft.date=1987-10-01&rft.volume=22&rft.issue=10&rft.spage=1288&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-03 N1 - Date created - 1987-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug fever: mechanisms, maxims and misconceptions. AN - 81051880; 3310641 AB - Although drug fever is a clinical entity that has received considerable attention in textbooks and review articles, only recently have such writings been subjected to critical analysis. In the present review, mechanisms responsible for drug fever are examined. In addition, published characterizations of the syndrome are compared with the results of a recently published systematic analysis of 148 cases of drug fever. This comparison identified a number of important areas in which descriptions of the clinical entity in textbooks and review articles are at odds with the clinical profile exhibited by actual cases of drug fever. JF - The American journal of the medical sciences AU - Mackowiak, P A AD - Medical Service, Veterans Administration Medical Center, Dallas, TX 75216. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 275 EP - 286 VL - 294 IS - 4 SN - 0002-9629, 0002-9629 KW - Pyrogens KW - 0 KW - Potassium Iodide KW - 1C4QK22F9J KW - Abridged Index Medicus KW - Index Medicus KW - Body Temperature Regulation KW - Pyrogens -- adverse effects KW - Humans KW - Middle Aged KW - Potassium Iodide -- adverse effects KW - Male KW - Fever -- chemically induced KW - Drug-Related Side Effects and Adverse Reactions KW - Fever -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81051880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Drug+fever%3A+mechanisms%2C+maxims+and+misconceptions.&rft.au=Mackowiak%2C+P+A&rft.aulast=Mackowiak&rft.aufirst=P&rft.date=1987-10-01&rft.volume=294&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-18 N1 - Date created - 1987-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse behavioral effects of amantadine therapy in Huntington's disease. AN - 81045650; 2958943 AB - Two patients with advanced Huntington's disease manifested a marked increase in irritability and aggressiveness when treated with amantadine during an epidemic of influenza. Amantadine should be used with caution in patients with Huntington's disease. JF - Southern medical journal AU - Stewart, J T AD - Inpatient Psychiatry Service, Gainesville Veterans Administration Medical Center, FL 32602. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1324 EP - 1325 VL - 80 IS - 10 SN - 0038-4348, 0038-4348 KW - Amantadine KW - BF4C9Z1J53 KW - Abridged Index Medicus KW - Index Medicus KW - Influenza, Human -- prevention & control KW - Humans KW - Adult KW - Male KW - Aggression -- drug effects KW - Amantadine -- therapeutic use KW - Amantadine -- adverse effects KW - Huntington Disease -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81045650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Adverse+behavioral+effects+of+amantadine+therapy+in+Huntington%27s+disease.&rft.au=Stewart%2C+J+T&rft.aulast=Stewart&rft.aufirst=J&rft.date=1987-10-01&rft.volume=80&rft.issue=10&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-19 N1 - Date created - 1987-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Causes of treatment failure with antiepileptic drugs vary over time. AN - 81039458; 3658167 AB - The V.A. Epilepsy Cooperative Study Group evaluated monotherapy with carbamazepine, phenobarbital, phenytoin, and primidone in a total of 622 patients with previously untreated partial seizures. In the 24 months following onset of treatment, 223 patients failed treatment. Analysis of these failures reveals that the majority occurred during the first 6 months with equal contributions to failure from systemic toxicity, neurotoxicity, and seizures. The contribution of systemic toxicity to failure was significantly less in the next 18 months. An increase in the contribution of seizures to failure was seen in this latter period. JF - Neurology AU - Homan, R W AU - Miller, B AD - Neurology Service, Dallas Veterans Administration Medical Center, TX 75216. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1620 EP - 1623 VL - 37 IS - 10 SN - 0028-3878, 0028-3878 KW - Anticonvulsants KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Humans KW - Nervous System -- drug effects KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Time Factors KW - Epilepsy -- physiopathology KW - Anticonvulsants -- adverse effects KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Anticonvulsants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81039458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Causes+of+treatment+failure+with+antiepileptic+drugs+vary+over+time.&rft.au=Homan%2C+R+W%3BMiller%2C+B&rft.aulast=Homan&rft.aufirst=R&rft.date=1987-10-01&rft.volume=37&rft.issue=10&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-03 N1 - Date created - 1987-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Soft tissue sarcoma and military service in Vietnam: a case-control study. AN - 81028399; 3116310 AB - A case-control study was conducted in men who were of draftable age during the Vietnam conflict to examine the association of soft tissue sarcomas (STSs) with military service in Vietnam as well as other host and environmental risk factors. A total of 217 STS cases selected from the Armed Forces Institute of Pathology were compared to 599 controls for Vietnam service, occupational and nonoccupational exposure to various chemicals, occupational history, medical history, and life-style (smoking, alcohol, coffee, etc.). Military service information was verified by a review of the patient's military personnel records. Other information was ascertained from a telephone interview with either subjects or their next of kin. Cases and controls were stratified on the basis of the hospital type (civilian, Veterans Administration, and military); the Mantel-Haenszel estimate of the odds ratio (OR), adjusted for the effects of the stratification variable, was calculated. Vietnam veterans in general did not have an increased risk of STS when compared to those men who had never been in Vietnam (OR, 0.85; 95% confidence interval, 0.54-1.36). Subgroups of Vietnam veterans who had higher estimated opportunities for Agent Orange exposure seemed to be at greater risk of STSs when their counterparts in Vietnam were taken as a reference group. However, this risk was not statistically significant. JF - Journal of the National Cancer Institute AU - Kang, H AU - Enzinger, F M AU - Breslin, P AU - Feil, M AU - Lee, Y AU - Shepard, B AU - Enziger, F AD - Department of Medicine and Surgery, Veterans Administration, Washington, DC 20006-3868. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 693 EP - 699 VL - 79 IS - 4 SN - 0027-8874, 0027-8874 KW - Polychlorinated Dibenzodioxins KW - 0 KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - Agent Orange KW - 39277-47-9 KW - 2,4,5-Trichlorophenoxyacetic Acid KW - 9Q963S4YMX KW - Index Medicus KW - Life Style KW - 2,4-Dichlorophenoxyacetic Acid -- adverse effects KW - Diagnosis-Related Groups KW - 2,4,5-Trichlorophenoxyacetic Acid -- adverse effects KW - Risk Factors KW - Polychlorinated Dibenzodioxins -- adverse effects KW - Humans KW - Male KW - Vietnam KW - Warfare KW - Soft Tissue Neoplasms -- chemically induced KW - Environmental Exposure KW - Sarcoma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81028399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Soft+tissue+sarcoma+and+military+service+in+Vietnam%3A+a+case-control+study.&rft.au=Kang%2C+H%3BEnzinger%2C+F+M%3BBreslin%2C+P%3BFeil%2C+M%3BLee%2C+Y%3BShepard%2C+B%3BEnziger%2C+F&rft.aulast=Kang&rft.aufirst=H&rft.date=1987-10-01&rft.volume=79&rft.issue=4&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Natl Cancer Inst 1987 Nov;79(5):1173 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 16,16-Dimethyl prostaglandin E2 reduced chenodeoxycholate-induced small intestinal mucosal injury in the rat. AN - 81023595; 3116133 AB - To determine whether prostaglandin may protect the small intestinal mucosa against bile acid-induced injury, we perfused in vivo rat jejunal segments with 5 mmol/L chenodeoxycholate with and without topical pretreatment with 2.6 mumol/L (1 microgram/ml) 16,16-dimethyl prostaglandin E2. Mucosal injury by chenodeoxycholate and its time sequence was assessed by using mannitol absorption and quantitative histology after 5, 15, 30, and 45 minutes of chenodeoxycholate perfusion. Forty-five-minute perfusion with chenodeoxycholate increased mannitol absorption from 0 to 0.9 nmol/min/cm, whereas prostaglandin pretreatment reduced this increase threefold (P less than 0.001). The increase in mannitol absorption coincided with progressive denudation of epithelial cells from intestinal villi. After 45 minutes exposure to chenodeoxycholate, an average of 50 micron of the cross-sectional surface of the villi tips was denuded of epithelial cells compared with only 25 micron denuded with prostaglandin pretreatment (P less than 0.01). These data indicate that topical administration of 16,16-dimethyl prostaglandin E2 reduces both the functional and morphologic small intestinal mucosal injury caused by chenodeoxycholate. JF - The Journal of laboratory and clinical medicine AU - Erickson, R A AU - Tarnawski, A AU - Krause, W J AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 387 EP - 395 VL - 110 IS - 4 SN - 0022-2143, 0022-2143 KW - Prostaglandins E, Synthetic KW - 0 KW - Chenodeoxycholic Acid KW - 0GEI24LG0J KW - Mannitol KW - 3OWL53L36A KW - 16,16-Dimethylprostaglandin E2 KW - M790V82VAC KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Permeability KW - Animals KW - Drug Interactions KW - Body Water -- metabolism KW - Mannitol -- metabolism KW - Intestinal Absorption KW - Time Factors KW - Male KW - Microscopy, Electron, Scanning KW - Prostaglandins E, Synthetic -- pharmacology KW - Intestine, Small -- drug effects KW - Intestinal Mucosa -- drug effects KW - 16,16-Dimethylprostaglandin E2 -- pharmacology KW - Chenodeoxycholic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81023595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=16%2C16-Dimethyl+prostaglandin+E2+reduced+chenodeoxycholate-induced+small+intestinal+mucosal+injury+in+the+rat.&rft.au=Erickson%2C+R+A%3BTarnawski%2C+A%3BKrause%2C+W+J&rft.aulast=Erickson&rft.aufirst=R&rft.date=1987-10-01&rft.volume=110&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemopreventive and antineoplastic activity of N-homocysteine thiolactonyl retinamide. AN - 81011402; 3652391 AB - N-homocysteine thiolactonyl retinamide was synthesized from trans retinoic acid and the free base of homocysteine thiolactone. In doses of 90-1800 mg/kg given i.p. in mixed lipid vehicle over nine weeks, the compound decreased to 60% of controls the number of lung tumors which was induced in A/J mice by 20 mg of ethyl carbamate. The highest dose also decreased the mean volume of lung tumors to 50% of controls, resulting in a total tumor volume of 30% of controls. Retinoic acid itself at 450 mg/kg was toxic, and no chemopreventive activity was observed. The free base and the lipophilic perchlorate salt of homocysteine thiolactone both increased the number of lung tumors to 114-117% of controls, indicating a co-carcinogenic effect. In C57BL/6N mice with transplanted MUO4 rhabdomyosarcoma, N-homocysteine thiolactonyl retinamide in a dose of 1000 mg/kg given over 11-21 days decreased the weight of the tumors to 30-70% of controls. These results show that N-homocysteine thiolactonyl retinamide has chemopreventive activity against chemical carcinogenesis and antineoplastic activity against a transplanted neoplasm. JF - Carcinogenesis AU - McCully, K S AU - Vezeridis, M P AD - Veterans Administration Medical Center, Providence, RI 02908. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1559 EP - 1562 VL - 8 IS - 10 SN - 0143-3334, 0143-3334 KW - Antineoplastic Agents KW - 0 KW - Homocysteine KW - 0LVT1QZ0BA KW - N-homocysteine thiolactonyl retinamide KW - 105918-76-1 KW - Urethane KW - 3IN71E75Z5 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Neoplasm Transplantation KW - Mice, Inbred A KW - Animals KW - Solubility KW - Lung Neoplasms -- drug therapy KW - Rhabdomyosarcoma -- chemically induced KW - Mice, Inbred C57BL KW - Mice KW - Lung Neoplasms -- chemically induced KW - Rhabdomyosarcoma -- drug therapy KW - Tretinoin -- pharmacology KW - Tretinoin -- analogs & derivatives KW - Homocysteine -- pharmacology KW - Homocysteine -- analogs & derivatives KW - Antineoplastic Agents -- therapeutic use KW - Tretinoin -- therapeutic use KW - Homocysteine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81011402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Chemopreventive+and+antineoplastic+activity+of+N-homocysteine+thiolactonyl+retinamide.&rft.au=McCully%2C+K+S%3BVezeridis%2C+M+P&rft.aulast=McCully&rft.aufirst=K&rft.date=1987-10-01&rft.volume=8&rft.issue=10&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytokeratin antigen in BOP-induced pancreatic tumors--implications for histogenesis. AN - 81010275; 2443264 AB - Pancreatic carcinoma induced in the Syrian hamster by the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) is of interest because of the ductal/ductular morphology of the tumors, which resembles human pancreatic cancer. However, whether hamster tumors arise from pre-existing ductal epithelium or from acinar cells has not yet been determined. The present study shows that a monoclonal antiserum to cytokeratin (an epithelial marker), when applied to normal hamster pancreas sections, stained centroacinar, ductular and ductal epithelium but did not stain acinar cells. We therefore examined pancreatic tissue from hamsters with benign and malignant neoplasms induced by BOP. The antiserum strongly stained the cells of all BOP-induced lesions (cysts, pseudoductules, hyperplasia, dysplasia and carcinomas). No acinar cell staining was observed in BOP-treated pancreas. These findings support the hypothesis that BOP-induced neoplasms arise from ductal epithelium and not from acinar cells. JF - Carcinogenesis AU - Bell, R H AU - Ray, M B AD - Department of Surgery, Veterans Administration Medical Center, Cincinnati, OH. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1563 EP - 1566 VL - 8 IS - 10 SN - 0143-3334, 0143-3334 KW - Antibodies, Monoclonal KW - 0 KW - Nitrosamines KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Animals KW - Adenocarcinoma -- chemically induced KW - Adenocarcinoma -- analysis KW - Mesocricetus KW - Immunohistochemistry KW - Male KW - Cricetinae KW - Pancreatic Neoplasms -- analysis KW - Pancreatic Neoplasms -- chemically induced KW - Keratins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81010275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Cytokeratin+antigen+in+BOP-induced+pancreatic+tumors--implications+for+histogenesis.&rft.au=Bell%2C+R+H%3BRay%2C+M+B&rft.aulast=Bell&rft.aufirst=R&rft.date=1987-10-01&rft.volume=8&rft.issue=10&rft.spage=1563&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Receptor-mediated monocytoid differentiation of human promyelocytic cells by tumor necrosis factor: synergistic actions with interferon-gamma and 1,25-dihydroxyvitamin D3. AN - 81009469; 2820533 AB - Human myeloid leukemia cells respond to various signals by differentiating to more mature cells. This study was designed to evaluate the effects of a mononuclear phagocyte-derived factor, tumor necrosis factor/cachectin (TNF), on the proliferation and differentiation of the human cell lines HL-60 (promyelocytic) and U937 (monoblastic), and to characterize TNF receptors on these cells. TNF had no effect on HL-60 cell growth or thymidine incorporation, but it markedly inhibited that of U937 cells. HL-60 cells treated with TNF formed osteoclast-like polykaryons and developed nonspecific esterase positivity. In a dose-dependent fashion, TNF enhanced HL-60 cell nonspecific esterase activity, H2O2 production, NBT reduction, and acid phosphatase content. Together, TNF and interferon-gamma (IFN-gamma) additively and synergistically caused increases in these activities as well as the expression of HLA-DR and the monocyte antigens LeuM3 (CDw14) and OKM1 (CD11). TNF also synergistically enhanced the differentiating effects of 1,25-dihydroxyvitamin D3. The potentiating actions of D3 of IFN-gamma on the TNF effect were maximal when the two agents were present together throughout the incubation, and pretreatment with TNF augmented the subsequent response to D3, but not IFN-gamma. HL-60 and U937 cells bound 125I-labeled TNF specifically, rapidly, and reversibly with binding constants of 227 and 333 pmol/L and receptors per cell of 4,435 and 6,806 for HL-60 and U937, respectively. Scatchard plots were linear, which suggested single classes of receptors. HL-60 TNF receptors were not changed by a three-day treatment with IFN-gamma or D3. U937 and HL-60 cells internalized and degraded 125I-labeled TNF to comparable degrees. TNF has differing effects on HL-60 and U937 cells that are apparently mediated through comparable high-affinity TNF receptors. The unique responses of different cell types to TNF may be due to postreceptor factors. JF - Blood AU - Weinberg, J B AU - Larrick, J W AD - Division of Hematology/Oncology, Veterans Administration Center, Durham, NC 27705. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 994 EP - 1002 VL - 70 IS - 4 SN - 0006-4971, 0006-4971 KW - Antigens, Surface KW - 0 KW - Receptors, Cell Surface KW - Receptors, Tumor Necrosis Factor KW - Interferon-gamma KW - 82115-62-6 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Calcitriol KW - FXC9231JVH KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Cell Division -- drug effects KW - Hydrogen Peroxide -- biosynthesis KW - Histocytochemistry KW - Drug Synergism KW - Cell Differentiation -- drug effects KW - Cell Line KW - Antigens, Surface -- analysis KW - Leukemia, Myeloid, Acute -- metabolism KW - Monocytes -- metabolism KW - Monocytes -- pathology KW - Interferon-gamma -- pharmacology KW - Leukemia, Myeloid, Acute -- pathology KW - Leukemia, Myeloid, Acute -- immunology KW - Receptors, Cell Surface -- physiology KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81009469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Receptor-mediated+monocytoid+differentiation+of+human+promyelocytic+cells+by+tumor+necrosis+factor%3A+synergistic+actions+with+interferon-gamma+and+1%2C25-dihydroxyvitamin+D3.&rft.au=Weinberg%2C+J+B%3BLarrick%2C+J+W&rft.aulast=Weinberg&rft.aufirst=J&rft.date=1987-10-01&rft.volume=70&rft.issue=4&rft.spage=994&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-10 N1 - Date created - 1987-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Blood 1988 Jan;71(1):272 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pindolol-induced tremor. AN - 78044871; 3332615 JF - Clinical neuropharmacology AU - Koller, W AU - Orebaugh, C AU - Lawson, L AU - Potempa, K AD - Edward Hines, Jr. Veterans Administration Hospital, Hines, IL. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 449 EP - 452 VL - 10 IS - 5 SN - 0362-5664, 0362-5664 KW - Propranolol KW - 9Y8NXQ24VQ KW - Pindolol KW - BJ4HF6IU1D KW - Index Medicus KW - Propranolol -- therapeutic use KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Male KW - Pindolol -- adverse effects KW - Pindolol -- therapeutic use KW - Tremor -- chemically induced KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78044871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neuropharmacology&rft.atitle=Pindolol-induced+tremor.&rft.au=Koller%2C+W%3BOrebaugh%2C+C%3BLawson%2C+L%3BPotempa%2C+K&rft.aulast=Koller&rft.aufirst=W&rft.date=1987-10-01&rft.volume=10&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Clinical+neuropharmacology&rft.issn=03625664&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-01 N1 - Date created - 1988-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of ammonia toxicity in the post transurethral prostatectomy syndrome. AN - 77879752; 3690208 AB - To investigate the aetiology of altered mental status following transurethral prostatectomy (TURP), serum electrolyte and blood ammonia levels were measured in 33 patients before and immediately after TURP. The irrigating fluid was 3% sorbitol in 12 patients and 1.5% glycine in 21. Serum electrolyte changes were similar in both groups. Elevated blood ammonia levels were observed in eight of the 21 patients receiving glycine irrigation. Three of these eight patients demonstrated clinical signs of encephalopathy. Absorption of glycine during transurethral prostatectomy appears to produce hyerammonaemia in some patients and may contribute to the encephalopathy. JF - British journal of urology AU - Shepard, R L AU - Kraus, S E AU - Babayan, R K AU - Siroky, M B AD - Veterans Administration Medical Center, Boston. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 349 EP - 351 VL - 60 IS - 4 SN - 0007-1331, 0007-1331 KW - Ammonia KW - 7664-41-7 KW - Sodium KW - 9NEZ333N27 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Therapeutic Irrigation KW - Syndrome KW - Humans KW - Aged KW - Sodium -- blood KW - Postoperative Period KW - Male KW - Prostatectomy -- adverse effects KW - Ammonia -- blood KW - Glycine -- pharmacokinetics KW - Glycine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77879752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+urology&rft.atitle=The+role+of+ammonia+toxicity+in+the+post+transurethral+prostatectomy+syndrome.&rft.au=Shepard%2C+R+L%3BKraus%2C+S+E%3BBabayan%2C+R+K%3BSiroky%2C+M+B&rft.aulast=Shepard&rft.aufirst=R&rft.date=1987-10-01&rft.volume=60&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=British+journal+of+urology&rft.issn=00071331&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Autonomic and endocrine participation in opioid peptide-induced hyperglycemia. AN - 77878918; 2826568 AB - Intracisternal administration of synthetic human beta-endorphin to conscious, ambulatory adult male rats caused dose-related increases in plasma glucose concentration. The largest dose of beta-endorphin examined, 7.25 nmol, increased plasma glucose concentration within 7 min and this effect lasted 2.5 h. On the other hand, only 58 pmol was required to induce transient hyperglycemia, when compared to the response observed in saline-injected control rats. This hyperglycemic effect of beta-endorphin was prevented by prior systemic administration of naloxone, thus supporting the hypothesis that this beta-endorphin-induced effect is mediated at opioid receptors. beta-Endorphin also markedly increased plasma concentrations of epinephrine, norepinephrine and, to a lesser extent, dopamine. A significant positive correlation was demonstrated between plasma glucose and plasma epinephrine responses to increasing doses of intracisternally administered beta-endorphin. In addition, intracisternal beta-endorphin also increased plasma glucagon concentration without significantly increasing plasma insulin concentration. Thus, it is probable that epinephrine and glucagon are the major factors mediating this hyperglycemic effect. beta-Endorphin-induced hyperglycemia was prevented by ganglionic blockade with chlorisondamine. This further supports the thesis that intracerebral beta-endorphin increases plasma glucose concentration by activation of the central autonomic outflow. In addition to these effects on short-term regulators of glycemia, intracisternal beta-endorphin increased plasma concentrations of corticosterone and growth hormone. Both of these glucose counterregulatory hormones may play minor roles in modulating beta-endorphin-induced hyperglycemia. JF - Journal of the autonomic nervous system AU - Appel, N M AU - Track, N S AU - Van Loon, G R AD - Veterans Administration Medical Center, Lexington, KY 40511. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 221 EP - 231 VL - 20 IS - 3 SN - 0165-1838, 0165-1838 KW - Insulin KW - 0 KW - Receptors, Opioid KW - beta-Endorphin KW - 60617-12-1 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Growth Hormone KW - 9002-72-6 KW - Glucagon KW - 9007-92-5 KW - Dopamine KW - VTD58H1Z2X KW - Corticosterone KW - W980KJ009P KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Animals KW - Injections, Intra-Arterial KW - Norepinephrine -- blood KW - Growth Hormone -- blood KW - Insulin -- blood KW - Epinephrine -- blood KW - Injections, Intraventricular KW - Rats, Inbred Strains KW - Rats KW - Corticosterone -- blood KW - Dopamine -- blood KW - Glucagon -- blood KW - Cisterna Magna KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Hyperglycemia -- chemically induced KW - beta-Endorphin -- pharmacology KW - beta-Endorphin -- administration & dosage KW - Receptors, Opioid -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77878918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+autonomic+nervous+system&rft.atitle=Autonomic+and+endocrine+participation+in+opioid+peptide-induced+hyperglycemia.&rft.au=Appel%2C+N+M%3BTrack%2C+N+S%3BVan+Loon%2C+G+R&rft.aulast=Appel&rft.aufirst=N&rft.date=1987-10-01&rft.volume=20&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+autonomic+nervous+system&rft.issn=01651838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Factor structure of the Addiction Severity Index in an inpatient detoxification sample. AN - 77877298; 3692636 AB - This study examines the factor structure of the Addiction Severity Index for a clinical sample of 190 males in an inpatient detoxification unit at a Veterans Administration hospital. Factor analysis revealed a four-factor solution rather than the six-factor solution originally suggested. These four factors (accounting for 22% of the common variance) were labeled chemical addiction, criminality, psychological distress, and health-related problems. Overall results suggest that considerably more work must be expended in developing standards for an interview schedule applicable to the chemically dependent. JF - The International journal of the addictions AU - Rogalski, C J AD - West Side Veterans Administration Hospital, Chicago, Illinois 60612. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 981 EP - 992 VL - 22 IS - 10 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Factor Analysis, Statistical KW - Crime KW - Humans KW - Adult KW - Middle Aged KW - Affective Symptoms -- complications KW - Male KW - Substance-Related Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77877298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Factor+structure+of+the+Addiction+Severity+Index+in+an+inpatient+detoxification+sample.&rft.au=Rogalski%2C+C+J&rft.aulast=Rogalski&rft.aufirst=C&rft.date=1987-10-01&rft.volume=22&rft.issue=10&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholic pancreatitis in rats fed ethanol in a nutritionally adequate liquid diet. AN - 77863509; 2447206 AB - In an effort to develop a model of chronic alcoholic pancreatitis in Sprague-Dawley rats fed a nutritionally adequate diet, 3 groups of 15 animals each were fed Wayne Rodent-Blox ad libitum, Lieber-DeCarli diet with 40% of carbohydrate calories replaced by ethanol ad libitum and isocaloric amounts of Lieber-DeCarli diet respectively for a period of 18 months. Rats were anesthetized and basal and secretin-stimulated pancreatic juice was obtained. Pancreatic glands were isolated and divided into portions for histology, biochemical analyses, and cell fractionation. The homogenate, zymogen granule fraction, mitochondrial-lysosomal fraction, microsomal fraction and postmicrosomal supernatant as well as aliquots of pancreatic juice were analyzed for cathepsin B, acid phosphatase, beta-D-glucoronidase, arylsulphatase and leucine naphthylamidase. All of the ethanol-fed animals developed morphological changes akin to human chronic pancreatitis. There were focal areas of parenchymal degeneration with fibrosis, protein plug formation and tubular complexes. In the pancreatic tissue of animals fed ethanol, total protein, trypsinogen (and free trypsin) were increased and amylase was decreased. While acid phosphatase was increased in all of the particulate fractions, cathepsin B was increased in the zymogen granule and mitochondrial-lysosomal fractions. Basal and post-secretin pancreatic juice did not show a significant increase in digestive or lysosomal enzymes. It is suggested that focal degenerative changes may be due to trypsin generated by intracellular activation of digestive enzymes by lysosomal enzyme cathepsin B. JF - International journal of pancreatology : official journal of the International Association of Pancreatology AU - Singh, M AD - Pancreatic Research Laboratory, Veterans Administration Medical Center, Augusta, GA 30910. PY - 1987 SP - 311 EP - 324 VL - 2 IS - 5-6 SN - 0169-4197, 0169-4197 KW - Ethanol KW - 3K9958V90M KW - Trypsinogen KW - 9002-08-8 KW - Acid Phosphatase KW - EC 3.1.3.2 KW - Amylases KW - EC 3.2.1.- KW - Trypsin KW - EC 3.4.21.4 KW - Cathepsin B KW - EC 3.4.22.1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Pancreas -- pathology KW - Animals KW - Acid Phosphatase -- metabolism KW - Amylases -- metabolism KW - Cathepsin B -- metabolism KW - Trypsin -- metabolism KW - Disease Models, Animal KW - Trypsinogen -- metabolism KW - Chronic Disease KW - Pancreas -- enzymology KW - Animal Nutritional Physiological Phenomena KW - Pancreatitis -- pathology KW - Pancreatitis -- enzymology KW - Food, Formulated KW - Ethanol -- administration & dosage KW - Ethanol -- toxicity KW - Pancreatitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77863509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.atitle=Alcoholic+pancreatitis+in+rats+fed+ethanol+in+a+nutritionally+adequate+liquid+diet.&rft.au=Singh%2C+M&rft.aulast=Singh&rft.aufirst=M&rft.date=1987-10-01&rft.volume=2&rft.issue=5-6&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.issn=01694197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An experience with epidural morphine in lumbar surgery patients. AN - 77856888; 2960754 AB - A chart review of the patients who received epidural morphine for lumbar surgery during the first year of implementation of the procedure was conducted. This article reviews the pharmacology and side effects of epidural morphine, describes the procedure of administering epidural morphine, discusses side effects and technical problems encountered, and presents implications for nursing practice. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Ozuna, J AU - Snyder, G AD - Department of Neurology, Veterans Administration Medical Center, Seattle, WA 98108. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 235 EP - 239 VL - 19 IS - 5 SN - 0888-0395, 0888-0395 KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Nursing KW - Injections, Epidural -- nursing KW - Humans KW - Catheters, Indwelling -- nursing KW - Morphine -- adverse effects KW - Pain, Postoperative -- drug therapy KW - Spinal Diseases -- surgery KW - Morphine -- administration & dosage KW - Lumbar Vertebrae -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77856888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=An+experience+with+epidural+morphine+in+lumbar+surgery+patients.&rft.au=Ozuna%2C+J%3BSnyder%2C+G&rft.aulast=Ozuna&rft.aufirst=J&rft.date=1987-10-01&rft.volume=19&rft.issue=5&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-22 N1 - Date created - 1987-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tissue levels of ibuprofen after fatal overdosage of ibuprofen and acetaminophen. AN - 77834188; 3686818 AB - Ibuprofen is a non-steroidal anti-inflammatory agent which is relatively safe and effective for the treatment of inflammatory disorders, but there are several reports of acute poisoning due to ibuprofen overdosage. Although the majority of ibuprofen overdosages are not very serious, acute renal failure, hepatic failure, and hypotension and coma have been described. We report here the case of a 48-year-old male who committed suicide by ingesting overdosages of both ibuprofen and acetaminophen. The case is unique because of the role ibuprofen played in his death, and because we were able to measure levels of ibuprofen in tissues obtained from post mortem examination. Tissue levels of ibuprofen have not previously been reported in humans. JF - Veterinary and human toxicology AU - Steinmetz, J C AU - Lee, C Y AU - Wu, A Y AD - Laboratory Service, Albany Veterans Administration Medical Center, New York 12208. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 381 EP - 383 VL - 29 IS - 5 SN - 0145-6296, 0145-6296 KW - Acetaminophen KW - 362O9ITL9D KW - Ibuprofen KW - WK2XYI10QM KW - Index Medicus KW - Humans KW - Middle Aged KW - Tissue Distribution KW - Male KW - Acetaminophen -- pharmacokinetics KW - Ibuprofen -- pharmacokinetics KW - Acetaminophen -- poisoning KW - Ibuprofen -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77834188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+and+human+toxicology&rft.atitle=Tissue+levels+of+ibuprofen+after+fatal+overdosage+of+ibuprofen+and+acetaminophen.&rft.au=Steinmetz%2C+J+C%3BLee%2C+C+Y%3BWu%2C+A+Y&rft.aulast=Steinmetz&rft.aufirst=J&rft.date=1987-10-01&rft.volume=29&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Veterinary+and+human+toxicology&rft.issn=01456296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-18 N1 - Date created - 1987-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS: A Medical Disaster AN - 61013316; 88U0669 AB - Most people still underestimate the scope of the medical disaster of AIDS (acquired immune deficiency syndrome). Medical, neurological, & psychiatric complications are catastrophic, but AIDS is preventable & can be controlled by changes in personal behavior. Voluntary testing adjunct to counseling should be encouraged. The role of family therapy in terminal illness has long been recognized & stressed; family support can be essential in AIDS management. Individual family members may also have specific concerns that merit recognition, including abandonment, anger, unrealistic guilt, & loss of control. 4 Tables. Modified HA JF - The European Journal of Psychiatry AU - Destounis, Nicholas P AD - Veterans Administration Medical Center, Lebanon PA 17042 Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 44 EP - 49 VL - 1 IS - 4 SN - 0213-6163, 0213-6163 KW - acquired immune deficiency syndrome epidemic, medical/psychiatric complications, treatment issues KW - Treatment Programs KW - Acquired Immune Deficiency Syndrome KW - Mental Health KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61013316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+Journal+of+Psychiatry&rft.atitle=AIDS%3A+A+Medical+Disaster&rft.au=Destounis%2C+Nicholas+P&rft.aulast=Destounis&rft.aufirst=Nicholas&rft.date=1987-10-01&rft.volume=1&rft.issue=4&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=The+European+Journal+of+Psychiatry&rft.issn=02136163&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - EJOPEO N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Treatment Programs; Mental Health ER - TY - JOUR T1 - Adult Foster Care: Past, Present, and Future AN - 1761723944; 198801581 AB - The evolution of adult foster care (AFC) in the US is traced, & some predictions are made about its possible future direction. AFC is recommended as a generic term for many community-based residential facilities caring for the mentally ill, mentally retarded, & frail elderly, as now used in Mich, where AFC homes are under the supervision & control of a single state agency, the Dept of Social Services. Some problems in AFC include public beliefs about social Darwinism & political conservatism, the potpourri of policy making & payment sources, means tested incomes of residents, lack of professional leadership, & bureaucrats with hidden agenda. Modified HA JF - Adult Foster Care Journal AU - McCoin, John M AD - Social Work Service Veterans Administration Medical Center, Leavenworth KS 66048 Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 170 EP - 180 VL - 1 IS - 3 KW - adult foster care, community-based residential institutions, Michigan model KW - Residential Institutions KW - United States of America KW - Adults KW - Foster Care KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761723944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adult+Foster+Care+Journal&rft.atitle=Adult+Foster+Care%3A+Past%2C+Present%2C+and+Future&rft.au=McCoin%2C+John+M&rft.aulast=McCoin&rft.aufirst=John&rft.date=1987-10-01&rft.volume=1&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Adult+Foster+Care+Journal&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States of America; Foster Care; Adults; Residential Institutions ER - TY - JOUR T1 - Efficacy of sucralfate and cimetidine in protection of the human gastric mucosa against alcohol injury. AN - 81050774; 3661609 AB - In order to study whether sucralfate or cimetidine may protect human gastric mucosa against alcohol injury, 28 healthy volunteers were pretreated with either: (1) placebo 1 g; (2) cimetidine (Tagamet) 300 mg; or (3) sucralfate (Carafate) 1 g. One hour later, 100 ml of 40 percent ethanol was sprayed directly on the gastric mucosa of the greater curvature during an endoscopic examination. Gastric mucosal changes were assessed by endoscopic appearance (according to grading scale) and by histology. In placebo-pretreated subjects, alcohol produced prominent mucosal damage (endoscopic score, 3.9 +/- 0.3, histologic score, 4.0 +/- 1.1 at 30 minutes). Cimetidine alkalinized gastric pH but did not prevent alcohol-induced damage (endoscopic score, 4.0 +/- 0.6; histologic score, 3.8 +/- 1.1, at 30 minutes). Sucralfate reduced endoscopic and histologic features of alcohol injury (endoscopic score, 1.8 +/- 0.6; histologic score, 1.8 +/- 1.1, at 30 minutes) without affecting gastric luminal pH. Reduction of alcohol-induced injury of the human gastric mucosa by sucralfate but not cimetidine demonstrates that effective protection of the gastric mucosa can be achieved without neutralization or inhibition of gastric acid secretion and points out another clinical application for sucralfate. JF - The American journal of medicine AU - Tarnawski, A AU - Glick, M E AU - Stachura, J AU - Hollander, D AU - Gergely, H AD - Gastroenterology Section, Veterans Administration Medical Center, Long Beach, California 90822. Y1 - 1987/09/28/ PY - 1987 DA - 1987 Sep 28 SP - 31 EP - 37 VL - 83 IS - 3B SN - 0002-9343, 0002-9343 KW - Placebos KW - 0 KW - Ethanol KW - 3K9958V90M KW - Sucralfate KW - 54182-58-0 KW - Cimetidine KW - 80061L1WGD KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Gastroscopy KW - Gastritis -- prevention & control KW - Humans KW - Adult KW - Adolescent KW - Male KW - Gastric Acid -- secretion KW - Sucralfate -- therapeutic use KW - Sucralfate -- administration & dosage KW - Cimetidine -- therapeutic use KW - Cimetidine -- administration & dosage KW - Ethanol -- toxicity KW - Gastric Mucosa -- drug effects KW - Gastric Mucosa -- secretion KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81050774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Efficacy+of+sucralfate+and+cimetidine+in+protection+of+the+human+gastric+mucosa+against+alcohol+injury.&rft.au=Tarnawski%2C+A%3BGlick%2C+M+E%3BStachura%2C+J%3BHollander%2C+D%3BGergely%2C+H&rft.aulast=Tarnawski&rft.aufirst=A&rft.date=1987-09-28&rft.volume=83&rft.issue=3B&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of memory processing by neuropeptide Y. AN - 77887611; 3690274 AB - Neuropeptide Y (NPY) is a 36 amino acid peptide which occurs in high concentrations in the amygdala and the hippocampus. The studies reported here demonstrate that administration of porcine NPY into the third ventricle of the brain enhanced memory retention for T-maze footshock avoidance and step-down passive avoidance training in mice. Human NPY at 5 micrograms enhanced retention but the inactive free acid form for NPY did not. NPY at 5 micrograms administered subcutaneously did not enhance retention. Post-training administration of NPY produced a dose-dependent, inverted U-shaped dose-response curve for retention of both passive and active avoidance conditioning. NPY enhanced retention in a time-dependent manner. NPY was also found to alleviate the amnesia caused by anisomycin, a protein synthesis inhibitor, and scopolamine, an anticholinergic. Pre-test administration of NPY improved recall but did not affect acquisition. These data support the concept that NPY is a modulator of memory processes. JF - Brain research AU - Flood, J F AU - Hernandez, E N AU - Morley, J E AD - Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Hospital, Sepulveda, CA 91343. Y1 - 1987/09/22/ PY - 1987 DA - 1987 Sep 22 SP - 280 EP - 290 VL - 421 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Neuropeptide Y KW - 0 KW - Index Medicus KW - Animals KW - Avoidance Learning -- physiology KW - Feeding Behavior -- physiology KW - Dose-Response Relationship, Drug KW - Mice KW - Avoidance Learning -- drug effects KW - Amnesia -- drug therapy KW - Amnesia -- chemically induced KW - Time Factors KW - Male KW - Injections, Intraventricular KW - Retention (Psychology) -- physiology KW - Memory -- drug effects KW - Neuropeptide Y -- pharmacology KW - Retention (Psychology) -- drug effects KW - Memory -- physiology KW - Neuropeptide Y -- physiology KW - Neuropeptide Y -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77887611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Modulation+of+memory+processing+by+neuropeptide+Y.&rft.au=Flood%2C+J+F%3BHernandez%2C+E+N%3BMorley%2C+J+E&rft.aulast=Flood&rft.aufirst=J&rft.date=1987-09-22&rft.volume=421&rft.issue=1-2&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combined hemodynamic and scintigraphic assessment of piroximone (MDL 19,205) and comparison with dobutamine and nitroprusside. AN - 81046432; 3661429 AB - The acute hemodynamic responses to intravenous infusion of piroximone (MDL 19,205), a nonglycoside, noncatecholamine agent with positive inotropic activity in vitro, were compared with those of intravenous dobutamine and sodium nitroprusside, respectively, in 2 groups of patients with New York Heart Association class III or IV symptoms. Each drug was titrated to optimal dosage (dobutamine, 12.5 +/- 3.9 micrograms/kg/min; nitroprusside, 2.5 +/- 0.6 micrograms/kg/min; piroximone 1.4 +/- 0.6 mg/kg) and simultaneous hemodynamic and scintigraphic values were measured. In group 1, the increase in cardiac index was slightly greater with piroximone than with dobutamine (from 1.6 +/- 0.5 to 2.7 +/- 0.6 vs 2.4 +/- 0.6 liters/min/m2, p less than 0.025) and only piroximone significantly decreased left ventricular (LV) filling pressure (from 29 +/- 7 to 22 +/- 8 mm Hg, p less than 0.05). Both agents increased heart rate and systolic blood pressure. In group 2, cardiac index increased similarly with nitroprusside and piroximone (1.5 +/- 0.6 to 2.6 +/- 0.8 and 1.6 +/- 0.5 to 2.6 +/- 0.5 liters/min/m2, difference not significant), whereas LV filling pressure decreased slightly less with piroximone (29 +/- 7 to 24 +/- 10 vs 30 +/- 7 to 20 +/- 11 mm Hg, difference not significant). Only nitroprusside reduced mean arterial pressure (88 +/- 13 to 72 +/- 12 mm Hg, p less than 0.001 between drugs). In group 1, systolic blood pressure to end-systolic volume ratio increased in 9 of 10 patients taking both piroximone and dobutamine, whereas in group 2, this ratio increased in 7 of 8 patients taking piroximone and declined in 7 of 8 taking nitroprusside.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American journal of cardiology AU - Massie, B M AU - Cornyn, J AU - Topic, N AU - Loge, D AU - Podolin, R A AD - Cardiology Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1987/09/15/ PY - 1987 DA - 1987 Sep 15 SP - 647 EP - 653 VL - 60 IS - 8 SN - 0002-9149, 0002-9149 KW - Ferricyanides KW - 0 KW - Imidazoles KW - Nitroprusside KW - 169D1260KM KW - piroximone KW - 2VSD0380YB KW - Dobutamine KW - 3S12J47372 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Radionuclide Imaging KW - Hemodynamics -- drug effects KW - Dobutamine -- administration & dosage KW - Heart Failure -- drug therapy KW - Ferricyanides -- therapeutic use KW - Imidazoles -- administration & dosage KW - Nitroprusside -- therapeutic use KW - Imidazoles -- therapeutic use KW - Nitroprusside -- adverse effects KW - Heart Failure -- diagnostic imaging KW - Dobutamine -- adverse effects KW - Imidazoles -- adverse effects KW - Heart Failure -- physiopathology KW - Dobutamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81046432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Combined+hemodynamic+and+scintigraphic+assessment+of+piroximone+%28MDL+19%2C205%29+and+comparison+with+dobutamine+and+nitroprusside.&rft.au=Massie%2C+B+M%3BCornyn%2C+J%3BTopic%2C+N%3BLoge%2C+D%3BPodolin%2C+R+A&rft.aulast=Massie&rft.aufirst=B&rft.date=1987-09-15&rft.volume=60&rft.issue=8&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-27 N1 - Date created - 1987-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Speaking rate of adventitiously deaf male cochlear implant candidates. AN - 85168121; pmid-3655119 AB - No objective group data on speaking rate or speaking duration have been reported on the speech of adventitiously profoundly hearing-impaired adults. Results of the present study showed that speaking rate, i.e., number of syllables per second, was significantly slower and speaking duration was significantly longer for 25 adventitiously profoundly hearing-impaired adult male cochlear implant candidates than for 10 normal-hearing control subjects. The factors of length of time since onset of profound hearing loss and hearing aid use did not significantly affect speaking rate. Based on these objective data, a rationale and method are presented for aural rehabilitation of the profoundly hearing-impaired who exhibit speaking rate abnormalities. JF - The Journal of the Acoustical Society of America AU - Leder, S B AU - Spitzer, J B AU - Kirchner, J C AU - Flevaris-Phillips, C AU - Milner, P AU - Richardson, F AD - Cochlear Implant Team/117A, Veterans Administration Medical Center, West Haven, Connecticut 06516. PY - 1987 SP - 843 EP - 846 VL - 82 IS - 3 SN - 0001-4966, 0001-4966 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85168121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Speaking+rate+of+adventitiously+deaf+male+cochlear+implant+candidates.&rft.au=Leder%2C+S+B%3BSpitzer%2C+J+B%3BKirchner%2C+J+C%3BFlevaris-Phillips%2C+C%3BMilner%2C+P%3BRichardson%2C+F&rft.aulast=Leder&rft.aufirst=S&rft.date=1987-09-01&rft.volume=82&rft.issue=3&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Decreased axonal transport in rat nerve following acute and chronic ethanol exposure. AN - 81100721; 2445363 AB - The axonal transport system, which supplies essential proteins and other cellular components to the distal portions of peripheral nerve axons, has been postulated to be the primary site of vulnerability inducing the peripheral neuropathies associated with neurotoxin exposure. Axonal transport was examined in normal rat dorsal root ganglia-sciatic nerve preparations incubated 28 hours in vitro in the presence of 79, 198 or 395 mg% ethanol. Exposure of the nerves to 395 mg% ethanol significantly reduced the accumulation of radiolabeled protein by 70%. Also, groups of rats were pair-fed an ethanol or isocaloric control diet for 9, 16 or 28 weeks. In vitro axonal transport was found to be unchanged in nerves of rats fed the ethanol diet for 9 weeks, but was significantly reduced 44% after 16 weeks and 47% after 28 weeks of ethanol feeding. These results suggest that interference with the axonal transport machinery by ethanol or perhaps acetaldehyde, its primary metabolite, may lead to the development of alcoholic peripheral neuropathy. JF - Alcohol (Fayetteville, N.Y.) AU - McLane, J A AD - Veterans Administration Hospital, Hines, IL 60141. PY - 1987 SP - 385 EP - 389 VL - 4 IS - 5 SN - 0741-8329, 0741-8329 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Alcoholism -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - Microtubules -- drug effects KW - Sciatic Nerve -- drug effects KW - Male KW - Ethanol -- pharmacology KW - Axonal Transport -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81100721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Decreased+axonal+transport+in+rat+nerve+following+acute+and+chronic+ethanol+exposure.&rft.au=McLane%2C+J+A&rft.aulast=McLane&rft.aufirst=J&rft.date=1987-09-01&rft.volume=4&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-24 N1 - Date created - 1987-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparisons of the cognitive functioning of familial and nonfamilial alcoholics. AN - 81078869; 3669668 AB - Alcoholic men (N = 81) participating in a Veterans Administration inpatient program were classified using four different strategies to describe the extent of familial alcoholism. These classification schemes included: (1) a comparison of alcoholics with no familial alcoholism, parental alcoholism or alcoholism in other relatives, (2) a unilineal-bilineal approach, (3) a multigenerational approach and (4) an approach that quantified the degree of familial alcoholism. Comparisons were made of the performance of the different familial history groups on a series of neuropsychological tests. No differences in cognitive functioning were found using any of the four classification schemes. JF - Journal of studies on alcohol AU - Alterman, A I AU - Gerstley, L J AU - Goldstein, G AU - Tarter, R E AD - Veterans Administration Medical Center, Philadelphia, Pennsylvania. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 425 EP - 429 VL - 48 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Cognition -- physiology KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81078869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Comparisons+of+the+cognitive+functioning+of+familial+and+nonfamilial+alcoholics.&rft.au=Alterman%2C+A+I%3BGerstley%2C+L+J%3BGoldstein%2C+G%3BTarter%2C+R+E&rft.aulast=Alterman&rft.aufirst=A&rft.date=1987-09-01&rft.volume=48&rft.issue=5&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-27 N1 - Date created - 1987-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Personality profiles of hospitalized pathological gamblers: the California Personality Inventory. AN - 81072126; 3667946 AB - Studies of the personality of the pathological gambler have consisted primarily of case reports and findings on the MMPI. This article presents data on a sample of 70 pathological gamblers, 70 alcoholics in treatment, and 70 medical/surgical controls on the California Personality Inventory (CPI). Gamblers and alcoholics differed significantly from hospitalized controls on a number of scales, particularly on measures of socialization, ego control, and flexibility. Differences between the gamblers and alcoholics were few, with a trend for the alcoholics to be similar to the gamblers and intermediate between the other two groups. Implications for the treatment of the pathological gambler are discussed. JF - Journal of clinical psychology AU - McCormick, R A AU - Taber, J AU - Kruedelbach, N AU - Russo, A AD - Cleveland Veterans Administration Medical Center. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 521 EP - 527 VL - 43 IS - 5 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Risk-Taking KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Alcoholism -- psychology KW - Male KW - Gambling -- psychology KW - Hospitalization KW - Personality Inventory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81072126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Personality+profiles+of+hospitalized+pathological+gamblers%3A+the+California+Personality+Inventory.&rft.au=McCormick%2C+R+A%3BTaber%2C+J%3BKruedelbach%2C+N%3BRusso%2C+A&rft.aulast=McCormick&rft.aufirst=R&rft.date=1987-09-01&rft.volume=43&rft.issue=5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-04 N1 - Date created - 1987-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Assessing pathological detoxification fear among methadone maintenance patients: the DFSS. AN - 81067275; 3667947 AB - This study assessed the reliability, validity, discriminative accuracy, and factor structure of the Detoxification Fear Survey Schedule (DFSS). Prevalence of detoxification fear and its correlates also were assessed. Random samples from three geographically, culturally, and racially disparate populations (N = 271) of treated opioid addicts were used. The DFSS had a test-retest r = .935 and demonstrated several indicants of validity. A briefer version (DFSS-14) showed superior psychometric properties and could identify correctly 81% of the detox fear subjects while it excluded 55% of nonfear subjects. The DFSS-14 had a replicated three-factor structure that accounted for 62.1% of total item variance in the validation sample. Factor two, probably best named dose reduction fear, was replicated in all populations. A cut-off score set at the nonfear mean is recommended for clinical use. A brief clinical interview of positive scorers quickly should eliminate false positives and, thus, efficiently identify most of those with detoxification fear. JF - Journal of clinical psychology AU - Milby, J B AU - Gurwitch, R H AU - Hohmann, A A AU - Wiebe, D J AU - Ling, W AU - McLellan, A T AU - Woody, G E AD - Psychology Service, Veterans Administration Medical Center, Birmingham, Alabama 35233. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 528 EP - 538 VL - 43 IS - 5 SN - 0021-9762, 0021-9762 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Inactivation, Metabolic KW - Humans KW - Adult KW - Psychometrics KW - Male KW - Female KW - Methadone -- adverse effects KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Fear KW - Opioid-Related Disorders -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Methadone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81067275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Assessing+pathological+detoxification+fear+among+methadone+maintenance+patients%3A+the+DFSS.&rft.au=Milby%2C+J+B%3BGurwitch%2C+R+H%3BHohmann%2C+A+A%3BWiebe%2C+D+J%3BLing%2C+W%3BMcLellan%2C+A+T%3BWoody%2C+G+E&rft.aulast=Milby&rft.aufirst=J&rft.date=1987-09-01&rft.volume=43&rft.issue=5&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-04 N1 - Date created - 1987-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of common pharmacologic agents on pulmonary antibacterial defenses: implications for the geriatric patient. AN - 81059562; 3311581 AB - Clinical and laboratory observations have raised the possibility that common pharmacologic agents disrupt lung host defense and predispose to bacterial infection of the lower respiratory tract. Epidemiologic data suggest that the potential for an impairment in pulmonary antibacterial mechanisms is greatest among individuals of advanced age. However, lung antimicrobial systems are extremely complex, and patients with pulmonary infections characteristically have a variety of predisposing conditions. Thus, it remains very difficult to assess the relative impact of drug-related derangements on lung antimicrobial systems. Indeed, it is likely that multiple intrinsic and extrinsic factors contribute to the evolution of most bacterial pneumonias. Thus, while medications may not represent major risk factors, they may act in an additive or synergistic manner with other predisposing conditions, such as age-associated changes in immunologic activity and underlying disease, to enhance susceptibility to infectious illnesses of the lung. Clearly, substantial clinical and laboratory study will be required in order to define the role that common pharmacologic agents play in predisposing to bacterial infection of the lower respiratory tract. JF - Clinics in chest medicine AU - Esposito, A L AD - Department of Medicine, Boston Veterans Administration Medical Center, Massachusetts. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 373 EP - 380 VL - 8 IS - 3 SN - 0272-5231, 0272-5231 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Immunity, Cellular -- drug effects KW - Aged KW - Antibody Formation -- drug effects KW - Lung -- immunology KW - Lung Diseases -- etiology KW - Bacterial Infections -- etiology KW - Immunocompetence -- drug effects KW - Drug-Related Side Effects and Adverse Reactions KW - Lung Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81059562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+chest+medicine&rft.atitle=The+effect+of+common+pharmacologic+agents+on+pulmonary+antibacterial+defenses%3A+implications+for+the+geriatric+patient.&rft.au=Esposito%2C+A+L&rft.aulast=Esposito&rft.aufirst=A&rft.date=1987-09-01&rft.volume=8&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Clinics+in+chest+medicine&rft.issn=02725231&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome. AN - 81049600; 3116849 AB - A 66-year-old man with the lupus anticoagulant-hypoprothrombinemia syndrome was treated with cyclophosphamide and prednisone to correct a factor II deficiency prior to elective major surgery. Whereas the lupus anticoagulant activity persisted, functional factor II levels normalized and he underwent surgery without a bleeding diathesis. Immunosuppressive therapy may temporarily normalize factor II levels in patients with the lupus anticoagulant-hypoprothrombinemia syndrome and reduce the risk of excessive hemorrhage. The disparate response of the lupus anticoagulant and hypoprothrombinemia to immunosuppression suggests that the lupus anticoagulant did not directly cause the hypoprothrombinemia. JF - The American journal of medicine AU - Simel, D L AU - St Clair, E W AU - Adams, J AU - Greenberg, C S AD - Division of Hematology-Oncology, Durham Veterans Administration Medical Center, North Carolina 27705. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 563 EP - 566 VL - 83 IS - 3 SN - 0002-9343, 0002-9343 KW - Autoantibodies KW - 0 KW - Blood Coagulation Factors KW - Immunosuppressive Agents KW - Lupus Coagulation Inhibitor KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Preoperative Care KW - Syndrome KW - Risk Factors KW - Humans KW - Postoperative Complications -- prevention & control KW - Hemorrhagic Disorders -- prevention & control KW - Aged KW - Male KW - Hypoprothrombinemias -- immunology KW - Cyclophosphamide -- therapeutic use KW - Prednisone -- therapeutic use KW - Autoantibodies -- immunology KW - Immunosuppressive Agents -- therapeutic use KW - Hypoprothrombinemias -- drug therapy KW - Blood Coagulation Factors -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81049600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Correction+of+hypoprothrombinemia+by+immunosuppressive+treatment+of+the+lupus+anticoagulant-hypoprothrombinemia+syndrome.&rft.au=Simel%2C+D+L%3BSt+Clair%2C+E+W%3BAdams%2C+J%3BGreenberg%2C+C+S&rft.aulast=Simel&rft.aufirst=D&rft.date=1987-09-01&rft.volume=83&rft.issue=3&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Predicting successful completion of an aftercare program following treatment for alcoholism: the role of dispositional optimism. AN - 81031187; 2821218 AB - In this study we investigated several variables as potential predictors of success in completing a transition program after treatment for alcoholism. Subjects were 54 men who had completed a 30-day treatment program and who were subsequently admitted to a 90-day inpatient aftercare program. The outcome measure was successful completion of this latter program. Predictor variables were dispositional optimism, hassles, uplifts, and several demographic variables. Optimism was positively associated with successful outcome. The simple association between uplifts and outcome also approached significance, but in the opposite to expected direction. Discriminant analyses used both of these variables, as well as age and education level, as predictors of successful outcome. There was no evidence of a role for hassles. Discussion centers on the importance of dispositional optimism as a predictor of successful adaptation in a variety of behavioral domains. JF - Journal of personality and social psychology AU - Strack, S AU - Carver, C S AU - Blaney, P H AD - Alcoholism Rehabilitation Laboratory, Veterans Administration Medical Center, Sepulveda, California. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 579 EP - 584 VL - 53 IS - 3 SN - 0022-3514, 0022-3514 KW - Index Medicus KW - Adaptation, Psychological KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Male KW - Alcoholism -- rehabilitation KW - Set (Psychology) KW - Motivation KW - Patient Compliance KW - Aftercare -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81031187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Predicting+successful+completion+of+an+aftercare+program+following+treatment+for+alcoholism%3A+the+role+of+dispositional+optimism.&rft.au=Strack%2C+S%3BCarver%2C+C+S%3BBlaney%2C+P+H&rft.aulast=Strack&rft.aufirst=S&rft.date=1987-09-01&rft.volume=53&rft.issue=3&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-18 N1 - Date created - 1987-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Elevation of chemotactic factor inactivator in alcoholic liver disease. AN - 81021432; 3653852 AB - Defective regulation of neutrophil chemotaxis occurs in patients with alcoholic liver disease. One potent mediator of neutrophil chemotaxis is the complement-derived neutrophil chemoattractant, C5a, which can be inhibited by a serum protein, chemotactic factor inactivator. We hypothesized that chemotactic factor inactivator elevation might, in part, explain the defective neutrophil chemotaxis seen in patients with alcoholic hepatitis. To test this hypothesis, sera were collected from 22 patients with alcoholic hepatitis and 9 normal controls, and evaluated for the antigenic presence of chemotactic factor inactivator using an ELISA test. Chemotactic factor inactivator levels were found to be markedly elevated in patients with alcoholic hepatitis (162 +/- 24 micrograms per ml) compared to normals (60 +/- 3 micrograms per ml, p less than 0.01). Subdividing the hepatitis patients revealed that the elevation of chemotactic factor inactivator was found to be greatest in those patients with mild alcoholic hepatitis (prothrombin time within normal limits and bilirubin less than or equal to 5 mg per dl, 256 +/- 44 micrograms per ml, p less than 0.001), while the group with the severest hepatic dysfunction (prolonged prothrombin time and bilirubin greater than 5 mg per dl) did not differ significantly from controls (71 +/- 11 micrograms/ml, p less than 0.2). Importantly, the inhibition of C5a-induced chemotactic activity by partially purified chemotactic factor inactivator correlated with antigenic amounts of chemotactic factor inactivator in serum (r = 0.63, p less than 0.05). The C5a inhibitory activity in sera obtained from patients with alcoholic hepatitis coprecipitated with chemotactic factor inactivator when serum was precipitated by ammonium sulfate precipitation (45 to 64% saturation).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Hepatology (Baltimore, Md.) AU - Robbins, R A AU - Zetterman, R K AU - Kendall, T J AU - Gossman, G L AU - Monsour, H P AU - Rennard, S I AD - Research Service, Omaha Veterans Administration Medical Center, Nebraska. PY - 1987 SP - 872 EP - 877 VL - 7 IS - 5 SN - 0270-9139, 0270-9139 KW - Antigens KW - 0 KW - Chemotactic Factors KW - Complement C5 KW - Immunoglobulin A KW - Immunoglobulin G KW - chemotactic factor inactivator KW - Complement C5a KW - 80295-54-1 KW - Aminopeptidases KW - EC 3.4.11.- KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Complement C5 -- analysis KW - Hepatitis, Alcoholic -- immunology KW - Immunoglobulin G -- analysis KW - Humans KW - Prothrombin Time KW - Chemotaxis, Leukocyte KW - Antigens -- analysis KW - Chromatography, Affinity KW - Hepatitis, Alcoholic -- blood KW - Neutrophils KW - Enzyme-Linked Immunosorbent Assay KW - Hepatitis, Alcoholic -- classification KW - Immunoglobulin A -- analysis KW - Bilirubin -- blood KW - Chemotactic Factors -- immunology KW - Chemotactic Factors -- antagonists & inhibitors KW - Chemotactic Factors -- blood KW - Aminopeptidases -- blood KW - Liver Diseases, Alcoholic -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81021432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Elevation+of+chemotactic+factor+inactivator+in+alcoholic+liver+disease.&rft.au=Robbins%2C+R+A%3BZetterman%2C+R+K%3BKendall%2C+T+J%3BGossman%2C+G+L%3BMonsour%2C+H+P%3BRennard%2C+S+I&rft.aulast=Robbins&rft.aufirst=R&rft.date=1987-09-01&rft.volume=7&rft.issue=5&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Crusted scabies in a diabetic alcoholic. AN - 81018104; 3654043 JF - International journal of dermatology AU - Klein, L J AU - Cole, G AD - Dermatology Service, Veterans Administration Medical Center, Long Beach, CA 90822. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 467 EP - 468 VL - 26 IS - 7 SN - 0011-9059, 0011-9059 KW - Index Medicus KW - Humans KW - Skin -- pathology KW - Adult KW - Male KW - Foot Dermatoses -- pathology KW - Alcoholism -- pathology KW - Scabies -- pathology KW - Diabetes Mellitus, Type 1 -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81018104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+dermatology&rft.atitle=Crusted+scabies+in+a+diabetic+alcoholic.&rft.au=Klein%2C+L+J%3BCole%2C+G&rft.aulast=Klein&rft.aufirst=L&rft.date=1987-09-01&rft.volume=26&rft.issue=7&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=International+journal+of+dermatology&rft.issn=00119059&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Portal hemodynamics during nitroglycerin administration in cirrhotic patients. AN - 81016778; 3115881 AB - Nitroglycerin is a potent venous dilator and a mild arterial vasodilator that has been shown to improve the hemodynamic response to vasopressin in portal hypertensive patients and to decrease portal pressure in experimental animals. In order to determine the effect of nitroglycerin on portal venous hemodynamics, we studied 11 patients with alcoholic cirrhosis before and during the administration of sublingual nitroglycerin (0.4 and 0.6 mg). The hepatic venous pressure gradient (which was obtained by subtracting the free hepatic venous pressure from the wedged hepatic venous pressure) decreased from 17.9 +/- 6.5 mm Hg (mean +/- S.D.) to 15.1 +/- 5.1 mm Hg (p less than 0.02) at the peak of the effect, which occurred from 2 to 12 min after nitroglycerin administration. The mean arterial pressure was reduced from 96 +/- 10 mm Hg to a peak decrease of 76 +/- 18 mmHg (p less than 0.001). The peak change in the hepatic venous pressure gradient induced by nitroglycerin correlated directly with the peak change in mean arterial pressure (r = 0.79, p less than 0.01). There was a moderate increase in heart rate in response to the decrease in blood pressure (73 +/- 15 to 83 +/- 15 beats per min, p less than 0.001). Two of the 11 patients did not reduce their hepatic venous pressure gradient after 0.6 mg nitroglycerin. Reductions in portal pressure were observed with both increases and moderate decreases in azygos blood flow, suggesting that, as observed in experimental animals, the portal-pressure-reducing effect of nitroglycerin could be due to two different and independent mechanisms, a reduction in portal blood flow or portal-collateral vasodilatation. JF - Hepatology (Baltimore, Md.) AU - Garcia-Tsao, G AU - Groszmann, R J AD - Hepatic Hemodynamic Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516. PY - 1987 SP - 805 EP - 809 VL - 7 IS - 5 SN - 0270-9139, 0270-9139 KW - Nitroglycerin KW - G59M7S0WS3 KW - Index Medicus KW - Heart Rate -- drug effects KW - Random Allocation KW - Hepatic Veins -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Liver Cirrhosis, Alcoholic -- complications KW - Hemodynamics -- drug effects KW - Nitroglycerin -- pharmacology KW - Portal System -- drug effects KW - Liver Cirrhosis, Alcoholic -- physiopathology KW - Hypertension, Portal -- etiology KW - Hypertension, Portal -- drug therapy KW - Nitroglycerin -- therapeutic use KW - Nitroglycerin -- administration & dosage KW - Hypertension, Portal -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81016778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Portal+hemodynamics+during+nitroglycerin+administration+in+cirrhotic+patients.&rft.au=Garcia-Tsao%2C+G%3BGroszmann%2C+R+J&rft.aulast=Garcia-Tsao&rft.aufirst=G&rft.date=1987-09-01&rft.volume=7&rft.issue=5&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A collagen coated vascular prosthesis. AN - 81014352; 2958479 AB - A woven, double velour Dacron vascular graft was made nonporous by coating it with a layer of collagen prepared from fresh, young calf skin. Grafts were implanted in the thoracic aorta of 24 mongrel dogs and were examined at intervals up to 180 days. The grafts did not require preclotting or special preparation before being implanted. They sutured easily and did not bleed. When explanted all grafts were patent and covered with neointima. The bovine collagen was almost completely resorbed by 90 days and was replaced with native tissue. The collagen was neither thrombogenic, antigenic, cytotoxic, or pyrogenic. JF - The Journal of cardiovascular surgery AU - Scott, S M AU - Gaddy, L R AU - Sahmel, R AU - Hoffman, H AD - Division of Cardiovascular and Thoracic Surgery, Veterans Administration Medical Center, Asheville, North Carolina. PY - 1987 SP - 498 EP - 504 VL - 28 IS - 5 SN - 0021-9509, 0021-9509 KW - Polyethylene Terephthalates KW - 0 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Aorta, Thoracic -- surgery KW - Animals KW - Cattle KW - Wound Healing KW - Dogs KW - Prosthesis Design KW - Microscopy, Electron KW - Materials Testing KW - Time Factors KW - Aorta, Thoracic -- pathology KW - Collagen -- toxicity KW - Blood Vessel Prosthesis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81014352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cardiovascular+surgery&rft.atitle=A+collagen+coated+vascular+prosthesis.&rft.au=Scott%2C+S+M%3BGaddy%2C+L+R%3BSahmel%2C+R%3BHoffman%2C+H&rft.aulast=Scott&rft.aufirst=S&rft.date=1987-09-01&rft.volume=28&rft.issue=5&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cardiovascular+surgery&rft.issn=00219509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-29 N1 - Date created - 1987-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of human cationic glutathione S-transferase by nonsubstrate ligands. AN - 81012078; 3653850 AB - Inhibition of a major hepatic form of human cationic glutathione S-transferase by bilirubin, biliverdin, indocyanine green and chenodeoxycholic acid was investigated as a function of pH (range = 6.5 to 9.1). Changes in pH had little effect on the extent of inhibition by indocyanine green. However, inhibition by bilirubin, biliverdin and chenodeoxycholic acid was found to be pH-dependent, with markedly less inhibition at the high values of pH. The reduced inhibition at the high values of pH could not be ascribed to a failure of the enzyme to bind the nonsubstrate ligand. Instead, the complete inhibition observed at pH 6.5 became partial (hyperbolic) inhibition at pH 9.1. This behavior can be ascribed to the binding of the nonsubstrate ligands at a site other than the active site, i.e., at high values of pH there is formation of an enzyme-substrate-inhibitor complex which still retains considerable catalytic activity. At physiologic values of pH (7.0), the human transferase was completely inhibited by saturating concentrations of the tested nonsubstrate ligands. This is in contrast to our previous studies performed with the rat transferases where, although inhibition also was affected by buffer pH, some forms of the enzyme retained significant catalytic activity at pH 7.0 despite high concentrations of nonsubstrate ligands. We conclude that the ability of the human cationic glutathione S-transferases to serve as enzymes of detoxification in the presence of high intracellular concentrations of nonsubstrate ligands may be significantly reduced, and this may render the cholestatic liver unusually susceptible to injury by toxic electrophiles. JF - Hepatology (Baltimore, Md.) AU - Boyer, T D AU - Vessey, D A AD - Liver Studies Unit, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1987 SP - 843 EP - 848 VL - 7 IS - 5 SN - 0270-9139, 0270-9139 KW - Cations KW - 0 KW - Ligands KW - Chenodeoxycholic Acid KW - 0GEI24LG0J KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Indocyanine Green KW - IX6J1063HV KW - Biliverdine KW - O9MIA842K9 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Rats KW - Animals KW - Indocyanine Green -- pharmacology KW - Cholestasis -- metabolism KW - Hydrogen-Ion Concentration KW - Humans KW - In Vitro Techniques KW - Bilirubin -- pharmacology KW - Biliverdine -- pharmacology KW - Substrate Specificity KW - Chenodeoxycholic Acid -- pharmacology KW - Catalysis KW - Liver -- enzymology KW - Glutathione Transferase -- antagonists & inhibitors KW - Glutathione Transferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81012078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Inhibition+of+human+cationic+glutathione+S-transferase+by+nonsubstrate+ligands.&rft.au=Boyer%2C+T+D%3BVessey%2C+D+A&rft.aulast=Boyer&rft.aufirst=T&rft.date=1987-09-01&rft.volume=7&rft.issue=5&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Formulation and food deprivation affects 2,4-D neurobehavioral toxicity in rats. AN - 77876034; 3696108 AB - The herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) is a commonly used herbicide and one component of Agent Orange. The herbicide is commonly formulated as the butyl ester. The effects of a 50:50 mixture of n-butyl and iso-butyl esters of 2,4-D (2,4-D mixed butyl esters, 150-175 mg/kg/day SC) on photocell locomotor activity and landing foot splay were assessed in rats. Similarly the effects of 2,4-D mixed butyl esters and pure 2,4-D-n-butyl ester (150 mg/kg/day SC) on photocell locomotor activity were assessed in both food deprived and free feeding rats. In general, food deprivation tended to decrease the sensitivity of rats to the effects of either formulation. The spectrum of neurobehavioral effects varied with the ester isomers. Both 2,4-D-n-butyl ester and 2,4-D mixed butyl esters depressed photocell locomotor activity. 2,4-D mixed butyl esters failed to increase landing foot splay as reported for 2,4-D-n-butyl ester. The extent of ester hydrolysis was similar when comparable concentrations of 2,4-D acid were measured in blood and brain four hours following either formulation. 2,4-D-n-butyl ester caused significantly more activity depression than 2,4-D mixed butyl esters. Additionally, tolerance developed more rapidly for animals receiving 2,4-D mixed butyl esters than for animals receiving 2,4-D-n-butyl ester. These studies exemplify the importance of herbicide formulation and subject nutritional status in the expression of neurobehavioral toxicity. JF - Neurotoxicology and teratology AU - Schulze, G E AD - Research Service, Veterans Administration Medical Center, Lexington, KY 40511. PY - 1987 SP - 363 EP - 367 VL - 9 IS - 5 SN - 0892-0362, 0892-0362 KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - 2,4-D n-butyl ester KW - 94-80-4 KW - Index Medicus KW - Rats KW - Drug Tolerance KW - Animals KW - Food Deprivation KW - Motor Activity -- drug effects KW - Male KW - Structure-Activity Relationship KW - Behavior, Animal -- drug effects KW - 2,4-Dichlorophenoxyacetic Acid -- administration & dosage KW - 2,4-Dichlorophenoxyacetic Acid -- metabolism KW - 2,4-Dichlorophenoxyacetic Acid -- toxicity KW - 2,4-Dichlorophenoxyacetic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77876034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Formulation+and+food+deprivation+affects+2%2C4-D+neurobehavioral+toxicity+in+rats.&rft.au=Schulze%2C+G+E&rft.aulast=Schulze&rft.aufirst=G&rft.date=1987-09-01&rft.volume=9&rft.issue=5&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-04 N1 - Date created - 1988-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dysgonic fermenter 2 septicemia. AN - 77845075; 3317733 AB - Dysgonic fermenter 2 (DF-2) is a slow-growing gram-negative bacillus causing a zoonotic infection that is acquired through dog bites or other contact with dogs. Splenectomized patients and those with alcoholic liver disease are most susceptible to DF-2 infection. The clinical picture can be one of fulminant septicemia and disseminated intravascular coagulation in the splenectomized patient; the presentation is milder in the alcoholic patient. The overall mortality from DF-2 septicemia among the 41 cases reported in the literature is 27%. The organism is sensitive to penicillin, resistant to aminoglycosides, and not easily grown on common media. It appears to be serum-sensitive in tests with normal human serum. Penicillin prophylaxis of dog bite wounds is especially important in high-risk patients. DF-2 infection should be considered when any splenectomized patient develops fulminant septicemia, disseminated intravascular coagulation, and peripheral gangrene. Examination of a gram stain of the peripheral blood or buffy coat is of value in such cases. JF - Reviews of infectious diseases AU - Hicklin, H AU - Verghese, A AU - Alvarez, S AD - Department of Medicine, Veterans Administration Medical Center, Johnson City, Tennessee 37684. PY - 1987 SP - 884 EP - 890 VL - 9 IS - 5 SN - 0162-0886, 0162-0886 KW - Index Medicus KW - Animals KW - Splenectomy KW - Risk Factors KW - Humans KW - Aged KW - Male KW - Sepsis -- etiology KW - Sepsis -- epidemiology KW - Dogs KW - Bites and Stings -- complications KW - Sepsis -- microbiology KW - Gram-Negative Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77845075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+infectious+diseases&rft.atitle=Dysgonic+fermenter+2+septicemia.&rft.au=Hicklin%2C+H%3BVerghese%2C+A%3BAlvarez%2C+S&rft.aulast=Hicklin&rft.aufirst=H&rft.date=1987-09-01&rft.volume=9&rft.issue=5&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Reviews+of+infectious+diseases&rft.issn=01620886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-15 N1 - Date created - 1988-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tardive dyskinesia. AN - 77834226; 2890765 JF - Journal of psychosocial nursing and mental health services AU - Scrak, B M AU - Greenstein, R A AD - Mental Hygiene Clinic, Veterans Administration Medical Center, Philadelphia, Pennsylvania 19102. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 24 EP - 27 VL - 25 IS - 9 SN - 0279-3695, 0279-3695 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Patient Education as Topic KW - Humans KW - Pennsylvania KW - Antipsychotic Agents -- adverse effects KW - Interprofessional Relations KW - Hospitals, Veterans KW - Dyskinesia, Drug-Induced -- nursing KW - Dyskinesia, Drug-Induced -- etiology KW - Outpatient Clinics, Hospital -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77834226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=Tardive+dyskinesia.&rft.au=Scrak%2C+B+M%3BGreenstein%2C+R+A&rft.aulast=Scrak&rft.aufirst=B&rft.date=1987-09-01&rft.volume=25&rft.issue=9&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-23 N1 - Date created - 1987-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Historic changes of occupational work load and mortality from peptic ulcer in Germany. AN - 77814541; 3316544 AB - The occurrence of peptic ulcer disease appears to be associated with the amount of occupational work load. Worldwide the number of hospital admissions, surgical operations, and death rates from gastric and duodenal ulcer have declined during recent decades. This communication examines the probability of a correlation between the time trends of gastric and duodenal ulcer mortality in Germany and changes in the occupational work load between 1870 and 1984. Lifetime cumulative hours of work declined for all consecutive cohorts of the population born between 1840 and 1955. The fall occurred similarly in all age groups. However, lifetime cumulative energy expenditure originating from industrial blue collar work showed a peak for the cohorts born during the last quarter of the 19th century. A marked decline occurred in all cohorts born after 1905. A similar birth-cohort pattern was found for mortality from peptic ulcer disease, with those born at the turn of the century showing a higher risk of dying from peptic ulcer disease than any previous or subsequent generation. The coincidence of the birth-cohort patterns of both mortality from peptic ulcer and occupational energy expenditure suggests that birth-cohort pattern of peptic ulcer may be related to the trends of occupational work load that occurred during the industrial revolution. The amount of work hours appears to be a less sensitive measure for the occupational work load. The superimposition of two counteracting historic changes, namely the increased industrial work force and the decreased occupational work load due to legislative regulations, industrial automation, and mechanization may have shaped the rise and fall in the occurrence of peptic ulcer disease. JF - Journal of occupational medicine. : official publication of the Industrial Medical Association AU - Sonnenberg, A AU - Sonnenberg, G S AU - Wirths, W AD - Department of Medicine, Veterans Administration Medical Center, Milwaukee, WI 53295. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 756 EP - 761 VL - 29 IS - 9 SN - 0096-1736, 0096-1736 KW - Index Medicus KW - History of medicine KW - Work Schedule Tolerance KW - History, 20th Century KW - Humans KW - Adult KW - History, 19th Century KW - Aged KW - Middle Aged KW - Germany KW - Energy Metabolism KW - Germany, West KW - Occupational Diseases -- history KW - Peptic Ulcer -- history KW - Peptic Ulcer -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77814541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.atitle=Historic+changes+of+occupational+work+load+and+mortality+from+peptic+ulcer+in+Germany.&rft.au=Sonnenberg%2C+A%3BSonnenberg%2C+G+S%3BWirths%2C+W&rft.aulast=Sonnenberg&rft.aufirst=A&rft.date=1987-09-01&rft.volume=29&rft.issue=9&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+medicine.+%3A+official+publication+of+the+Industrial+Medical+Association&rft.issn=00961736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-21 N1 - Date created - 1987-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Atrial Pacing During Percutaneous Transluminal Coronary Angioplasty: Results and Comparison with Exercise Treadmill Testing AN - 20075028; 10100293 AB - Right atrial pacing (RAP) was used to immediately assess improvement in threshold for myocardial ischemia in 23 patients undergoing angiographically successful percutaneous transluminal coronary angioplasty (PTCA). Multiple coronary lesions were present in 19 patients, and 15 had incomplete revascular ization. All patients had RAP done immediately before and after completion of all dilatations, and in 13 patients pre- and post-PTCA exercise treadmill tests (ETT) were also performed. Angina occurred in 16 (70%) patients during pre- PTCA RAP, but in only 4 (17%) after PTCA (p < .05). The electrocardiogram was positive for ischemia (horizontal or downsloping ST depression greater than or equal to 1 mm) in 18 patients (78%) during pre-PTCA RAP. However, 13 patients (57%) continued to have an ischemic response during post-PTCA RAP (not significant-NS). In 4 patients with multiple coronary lesions who had sequential pacing studies after PTCA of each lesion, the maximum degree of ST depression decreased by 1 mm or more after each dilatation in 3 patients but remained greater than or equal to 1 mm in all. In the 13 patients undergoing both RAP and ETT, angina developed in 7 during pre- PTCA RAP and in 2 after PTCA (p < .05), compared with 8 and 3 (p < .05) during pre- and post-PTCA ETT, respectively. Ischemic ST depression occurred in 9 patients during pre-PTCA RAP and in 6 after PTCA (NS), and in 8 and 6 (NS) during pre- and post-PTCA ETT, respectively. Concordance between the two tests was good. The authors conclude that RAP can be used to document improvements in the threshold for ischemia as assessed by angina and, less consistently, by ST depression. However, use of RAP to guide PTCA of individ ual lesions is limited in patients with multiple coronary lesions (especially those undergoing incomplete revascularization), owing to difficulty in determining which lesion(s) are responsible for persistent ischemic ST depression (present in most patients with positive pre-PTCA tests) after PTCA. RAP does compare favorably with ETT for assessing post-PTCA ischemia and can be used as a substitute for exercise testing in patients unable to perform an adequate ETT. JF - Angiology AU - Stratmann, Henry AU - Aker, Umit T AU - Vandormael, Michael G AU - Ischinger, Thomas AU - Wiens, Robert AU - Kennedy, Harold L AD - Department of Cardiology, St. Louis Veterans Administration Medical Center and St. Louis University, St. Louis, Missouri Y1 - 1987/09// PY - 1987 DA - Sep 1987 SP - 663 EP - 671 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 9 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Blood flow KW - Motor performance tests KW - Patients KW - Treadmill ergometry KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20075028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Atrial+Pacing+During+Percutaneous+Transluminal+Coronary+Angioplasty%3A+Results+and+Comparison+with+Exercise+Treadmill+Testing&rft.au=Stratmann%2C+Henry%3BAker%2C+Umit+T%3BVandormael%2C+Michael+G%3BIschinger%2C+Thomas%3BWiens%2C+Robert%3BKennedy%2C+Harold+L&rft.aulast=Stratmann&rft.aufirst=Henry&rft.date=1987-09-01&rft.volume=38&rft.issue=9&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331978703800903 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood flow; Motor performance tests; Patients; Treadmill ergometry; Heart diseases DO - http://dx.doi.org/10.1177/000331978703800903 ER - TY - JOUR T1 - Trabecular bone density and menstrual function in women runners AN - 20050317; 10093038 AB - Osteoporosis results in decreased bone mineral mass and reduced trabecular bone density. Although its etiol ogy remains unknown, studies have revealed differen tial changes in the bone mineral densities of postmeno pausal women, anorexic women, and amenorrheic fe male athletes. Correlations have also been made be tween estrogen deficiency and osteoporosis in both premenopausal and postmenopausal women. In order to examine the possibility of osteopenia, a group of 36 female runners between the ages of 15 and 44 years were evaluated for bone mineral density, menstrual function, and dietary habits. Serum calcium, phospho rus, and parathyroid hormone (PTH) levels were also determined for each participant, as were complete blood counts. Using dual photon absorptiometry, all participants underwent a 20 minute scan of the lumbar spine with specificity to the L1-14 vertebrae. The 36 subjects included 19 oligomenorrheic and 17 eumenor rheic women. Results of bone density analyses re vealed that the oligomenorrheic runners had signifi cantly lower calibrated bone mineral density (CBMD) than their eumenorrheic counterparts (P << 0.01 ). Like wise, the PTH levels of the oligomenorrheic runners were also significantly lower (P << 0.01). Analysis of dietary logs revealed no significant differences between the dietary habits, the calcium intake, or the caloric intake of the two groups. The data from this study indicate that there is a relationship between reduced serum PTH levels and the oligomenorrheic state. The loss of the protective effect of estrogen in the oligo menorrheic runners possibly contributed to their re duced bone mineral densities and could be a contrib uting factor in osteopenia. JF - American Journal of Sports Medicine AU - Cook, Stephen D AU - Harding, Amanda F AU - Thomas, Kevin A AU - Morgan, Edward L AU - Schnurpfeil, Kimberly M AU - Haddad, Ray J AD - Department of Orthopaedic Surgery, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, Louisiana Y1 - 1987/09// PY - 1987 DA - Sep 1987 SP - 503 EP - 507 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 15 IS - 5 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - Age KW - Dual photon absorptiometry KW - Bones KW - Women KW - Vertebrae KW - Osteopenia KW - Calcium (dietary) KW - Bone mineral density KW - Post-menopause KW - Parathyroid hormone KW - Bone mass KW - Estrogens KW - Data processing KW - Estrogen KW - Running KW - Osteoporosis KW - Calcium (blood) KW - Spine (lumbar) KW - Blood KW - Spine KW - Analysis KW - Menstruation KW - Minerals KW - PE 090:Sports Medicine & Exercise Sport Science KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20050317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Trabecular+bone+density+and+menstrual+function+in+women+runners&rft.au=Cook%2C+Stephen+D%3BHarding%2C+Amanda+F%3BThomas%2C+Kevin+A%3BMorgan%2C+Edward+L%3BSchnurpfeil%2C+Kimberly+M%3BHaddad%2C+Ray+J&rft.aulast=Cook&rft.aufirst=Stephen&rft.date=1987-09-01&rft.volume=15&rft.issue=5&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658701500514 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Blood; Spine; Bones; Bone mineral density; Estrogen; Analysis; Running; Women; Minerals; Age; Estrogens; Data processing; Dual photon absorptiometry; Osteoporosis; Calcium (blood); Vertebrae; Osteopenia; Spine (lumbar); Calcium (dietary); Post-menopause; Parathyroid hormone; Menstruation; Bone mass DO - http://dx.doi.org/10.1177/036354658701500514 ER - TY - JOUR T1 - Labial kinematics during speech in patients with parkinsonian rigidity. AN - 85226542; pmid-3651793 AB - Studies of orofacial motor control in Parkinson's disease (PD) have demonstrated that these subjects may exhibit hypokinesia and bradykinesia, as well as increased muscle tone. Yet the relationship between aberrations of orofacial movement and muscle rigidity remains unclear. Measures of labial muscle rigidity and movement were made for 12 parkinsonian and 9 age-matched control subjects. Displacement amplitude, peak instantaneous velocity, and movement time were evaluated during repetitive syllable productions. The results showed that while mean parkinsonian displacement amplitudes and velocities were lower than the normal control subjects, there was no statistical relationship between labial rigidity and the degree of movement abnormality. It is concluded that while rigidity may play a part in the overall disability, it does not sufficiently explain the labial articulatory difficulties associated with parkinsonism. This is in agreement with the literature on limb rigidity and movement aberrations in PD, suggesting that rigidity and bradykinesia may represent independent pathophysiological phenomena. JF - Brain AU - Caligiuri, M P AD - Research Section, Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 1033 EP - 1044 VL - 110 ( Pt 4) SN - 0006-8950, 0006-8950 KW - Lip KW - Support, U.S. Gov't, P.H.S. KW - Parkinson Disease KW - Human KW - Aged KW - Middle Age KW - Muscle Rigidity KW - Support, U.S. Gov't, Non-P.H.S. KW - Speech KW - Male KW - Movement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain&rft.atitle=Labial+kinematics+during+speech+in+patients+with+parkinsonian+rigidity.&rft.au=Caligiuri%2C+M+P&rft.aulast=Caligiuri&rft.aufirst=M&rft.date=1987-08-01&rft.volume=110+%28+Pt+4%29&rft.issue=&rft.spage=1033&rft.isbn=&rft.btitle=&rft.title=Brain&rft.issn=00068950&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Observations about amyotrophic lateral sclerosis and the parkinsonism-dementia complex of Guam with regard to epidemiology and etiology. AN - 81106786; 3315143 AB - For more than 150 years, Chamorro natives of the Mariana Islands in the Western Pacific Ocean, have developed fatal paralysis in middle and later life, which we term amyotrophic lateral sclerosis/parkinsonism-dementia (ALS/PD). The cause of the disease might be exposure to seeds of the indigenous cycad. Motor system disease is induced in cynomolgus monkeys by feeding them beta-N-methylamino-L-alanine (BMAA), an amino acid present in cycad seeds. We believe that the cycad seeds which usually cause no immediate adverse symptoms when prepared and eaten as flour, or applied topically as medicine, can give rise to widespread and severe nerve cell degeneration after a latency of many decades. Furthermore, it may be that only a single exposure to this potent but silent toxin(s) can result in fatal neurological disease years later. JF - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques AU - Steele, J C AU - Guzman, T AD - Veterans Administration Office, U.S. Naval Hospital, Guam. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 358 EP - 362 VL - 14 IS - 3 Suppl SN - 0317-1671, 0317-1671 KW - Index Medicus KW - History of medicine KW - History, 20th Century KW - Humans KW - Guam KW - History, 19th Century KW - Plants, Toxic KW - Alzheimer Disease -- epidemiology KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Parkinson Disease, Secondary -- epidemiology KW - Amyotrophic Lateral Sclerosis -- etiology KW - Alzheimer Disease -- etiology KW - Diet KW - Parkinson Disease, Secondary -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81106786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Canadian+journal+of+neurological+sciences.+Le+journal+canadien+des+sciences+neurologiques&rft.atitle=Observations+about+amyotrophic+lateral+sclerosis+and+the+parkinsonism-dementia+complex+of+Guam+with+regard+to+epidemiology+and+etiology.&rft.au=Steele%2C+J+C%3BGuzman%2C+T&rft.aulast=Steele&rft.aufirst=J&rft.date=1987-08-01&rft.volume=14&rft.issue=3+Suppl&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=The+Canadian+journal+of+neurological+sciences.+Le+journal+canadien+des+sciences+neurologiques&rft.issn=03171671&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-13 N1 - Date created - 1988-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evidence for the generation of transaminase inhibitor(s) during ethanol metabolism by rat liver homogenates: a potential mechanism for alcohol toxicity. AN - 81060513; 3663401 AB - Since ethanol consumption decreases hepatic aminotransferase activities in vivo, mechanisms of ethanol-mediated transaminase inhibition were explored in vitro using mitochondria-depleted rat liver homogenates. When homogenates were incubated at 37 degrees with 50 mM ethanol for 1 hr, alanine aminotransferase decreased by 20%, while aspartate aminotransferase was unchanged. After 2 hr, aspartate aminotransferase decreased by 20% and by 3 hr, alanine and aspartate aminotransferases were decreased by 31 and 23%, respectively. Levels of acetaldehyde generated during ethanol oxidation were 525 +/- 47 microM at 1 hr, 855 +/- 14 microM at 2 hr, and 1293 +/- 140 microM at 3 hr. Although inhibition of alcohol oxidation with methylpyrazole or cyanide markedly decreased ethanol-mediated transaminase inhibition, neither incubation with acetate nor generation of reducing equivalents by oxidation of lactate, malate, xylitol, or sorbitol altered the activity of either enzyme. However, semicarbazide, an aldehyde scavenger, prevented inhibition of both aminotransferases by ethanol. Moreover, incubation with 5 mM acetaldehyde for 1 hr inhibited alanine and aspartate aminotransferases by 36 and 26%, respectively. Cyanamide, an aldehyde dehydrogenase inhibitor, had little effect on ethanol-mediated transaminase inhibition. Thus, metabolism of ethanol by rat liver homogenates produces transaminase inhibition similar to that described in vivo and this effect requires acetaldehyde generation but not acetaldehyde oxidation. Since addition of pyridoxal 5'-phosphate to assay mixes did not reverse ethanol effects, aminotransferase inhibition does not result from displacement of vitamin B6 coenzymes. JF - Biochemical medicine and metabolic biology AU - Solomon, L R AD - Department of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 9 EP - 18 VL - 38 IS - 1 SN - 0885-4505, 0885-4505 KW - Semicarbazides KW - 0 KW - Ethanol KW - 3K9958V90M KW - Cyanamide KW - 420-04-2 KW - Sorbitol KW - 506T60A25R KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Sodium Cyanide KW - O5DDB9Z95G KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Sodium Cyanide -- pharmacology KW - Animals KW - Acetaldehyde -- pharmacology KW - Cyanamide -- pharmacology KW - Kinetics KW - Cytosol -- enzymology KW - Sorbitol -- pharmacology KW - Semicarbazides -- pharmacology KW - Alanine Transaminase -- antagonists & inhibitors KW - Liver -- pathology KW - Aspartate Aminotransferases -- antagonists & inhibitors KW - Liver -- drug effects KW - Liver -- metabolism KW - Ethanol -- toxicity KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81060513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+medicine+and+metabolic+biology&rft.atitle=Evidence+for+the+generation+of+transaminase+inhibitor%28s%29+during+ethanol+metabolism+by+rat+liver+homogenates%3A+a+potential+mechanism+for+alcohol+toxicity.&rft.au=Solomon%2C+L+R&rft.aulast=Solomon&rft.aufirst=L&rft.date=1987-08-01&rft.volume=38&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Biochemical+medicine+and+metabolic+biology&rft.issn=08854505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-27 N1 - Date created - 1987-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seasonal changes in lead absorption in laboratory rats. AN - 81054233; 3665864 AB - A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male Wistar rats weighing 200 to 250 g were given 1 microgram of radiolabeled lead in an aqueous solution, pH 4.0, in isolated small intestine, and absorption of the radiolead was quantified after a 4-hour interval using whole-body counting. Similar values of absorption occurred in the summer (June-August) and fall (September-November), 20.51 +/- 1.11% (1 SEM) and 23.0 +/- 1.23% of the test dose, respectively, but significantly lower values occurred in the winter (December-February) and spring (March-May): 16.51 +/- 0.77%, p less than 0.01, and 11.87 +/- 0.99%, p less than 0.01, respectively. Harmonic analysis yielded an excellent approximation of the mean quarterly absorption data. The resulting cosine function had a period of 4.08 +/- 0.05 quarter-years with an amplitude of 7.32 +/- 1.06%; predicted peak absorption values fell precisely between summer and fall. The relationships of these observations to possible mechanisms of lead absorption and to summertime epidemics of lead poisoning in children are discussed. JF - Environmental health perspectives AU - Barton, J C AU - Huster, W J AD - Veterans Administration Medical Center, Birmingham, AL 35233. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 209 EP - 214 VL - 73 SN - 0091-6765, 0091-6765 KW - Lead Radioisotopes KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Rats KW - Animals KW - Seasons KW - Animals, Laboratory KW - Male KW - Intestinal Absorption KW - Lead -- metabolism KW - Rats, Inbred Strains -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Seasonal+changes+in+lead+absorption+in+laboratory+rats.&rft.au=Barton%2C+J+C%3BHuster%2C+W+J&rft.aulast=Barton&rft.aufirst=J&rft.date=1987-08-01&rft.volume=73&rft.issue=&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1968 Jul 25;243(14):3987-93 [4298517] Am J Physiol. 1960 Mar;198:609-13 [13817887] Pediatrics. 1969 Nov;44(5):661-7 [5374977] J Lab Clin Med. 1972 Jan;79(1):128-36 [5007557] N Engl J Med. 1973 Dec 13;289(24):1289-93 [4584189] N Engl J Med. 1974 Feb 28;290(9):520 [4810822] Science. 1974 May 31;184(4140):952-6 [4596821] Experientia. 1975 Nov 15;31(11):1320-1 [1204790] Arch Environ Health. 1977 Jul-Aug;32(4):160-4 [889354] J Lab Clin Med. 1977 Oct;90(4):700-6 [903699] Soc Sci Med. 1977 Nov;11(14-16):691-703 [563625] J Lab Clin Med. 1978 Mar;91(3):366-76 [24077] Gastroenterology. 1978 Apr;74(4):731-40 [631510] J Nutr. 1978 May;108(5):843-7 [205639] Proc Natl Acad Sci U S A. 1978 Jul;75(7):3517-21 [277955] Br J Nutr. 1978 Sep;40(2):253-60 [698163] J Lab Clin Med. 1978 Oct;92(4):536-47 [712193] Proc Soc Exp Biol Med. 1978 Nov;159(2):213-8 [568797] Br Med J. 1979 Jan 27;1(6158):221-3 [311234] Am J Public Health. 1979 Apr;69(4):348-52 [426160] J Clin Endocrinol Metab. 1979 May;48(5):771-5 [429522] Gastroenterology. 1979 Nov;77(5):1074-81 [488634] Experientia. 1979 Dec 15;35(12):1581-2 [574832] Am J Physiol. 1980 Feb;238(2):G124-30 [7361899] N Engl J Med. 1980 May 15;302(20):1128-31 [7366636] Lancet. 1980 Aug 2;2(8188):236-7 [6105398] Proc Soc Exp Biol Med. 1981 Jan;166(1):64-9 [7465576] Br Med J (Clin Res Ed). 1981 Apr 25;282(6273):1349-52 [6786491] J Clin Endocrinol Metab. 1981 Jul;53(1):139-42 [6972382] J Nutr. 1981 Aug;111(8):1321-9 [6267235] Am J Clin Nutr. 1981 Oct;34(10):2192-8 [7293946] Res Commun Chem Pathol Pharmacol. 1981 Dec;34(3):515-30 [7323447] Am J Clin Nutr. 1982 Jun;35(6):1327-31 [6896257] Clin Biochem. 1982 Aug;15(4):206-11 [7127727] Neuroendocrinology. 1982 Nov;35(5):342-8 [7145026] Blood. 1983 Feb;61(2):283-90 [6821698] Comp Biochem Physiol A Comp Physiol. 1983;74(2):363-7 [6131779] J Endocrinol. 1983 May;97(2):179-85 [6406632] J Nutr. 1984 Apr;114(4):692-700 [6325646] Am J Physiol. 1984 Aug;247(2 Pt 1):G193-8 [6465315] South Med J. 1955 Mar;48(3):298-301 [14358906] J Am Med Assoc. 1955 May 7;158(1):15-20 [14367028] N Y State J Med. 1956 Dec 1;56(23):3711-4 [13378660] Pediatrics. 1958 Jan;21(1):40-6 [13494075] Scand J Clin Lab Invest. 1958;10 Supp 36:1-290 [13634930] Guys Hosp Rep. 1962;111:306-12 [13967523] Comp Biochem Physiol. 1969 Jul 1;30(1):177-83 [5804479] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo functional antagonism between isoproterenol and bronchoconstrictants in the dog. AN - 81026740; 3308812 AB - The functional antagonism between isoproterenol and methacholine, histamine and serotonin, as described in vitro in respiratory smooth muscle was explored in vivo in a canine model. Infusions of isoproterenol were administered during brief peaks of bronchospasm produced by aerosolized methacholine and histamine, or during sustained bronchospasm produced by infused serotonin. In eight mongrel dogs anesthetized with pentobarbital sodium, the mean protection by infused isoproterenol against methacholine challenge decreased from 60.6 to 29.1% as the mean lung resistance (RL) was increased from 78 to 232% over base line by a fourfold increase in methacholine (P less than 0.002). In six dogs, the mean protection by isoproterenol against histamine decreased from 55.5 to 26.9% as the opposing RL increased from 80 to 182% over base line with a fourfold increase in histamine (P less than 0.02). However, with serotonin infusions there was only a small 18% mean decrease in protection (P = 0.05), associated with a correspondingly small 37% mean increase in dose of serotonin despite a 269% mean increase in resistance (P = 0.02). In all cases, the loss of protection correlated more closely with the dose of constrictant than the resistance increase over base line. These findings demonstrate in vivo functional antagonism between isoproterenol and the dose of bronchoconstrictant but not necessarily resistance increase per se. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Jenne, J W AU - Shaughnessy, T K AU - Druz, W S AU - Manfredi, C J AU - Vestal, R E AD - Medical Service, Edward Hines Jr., Veterans Administration Hospital, Hines, Illinois. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 812 EP - 819 VL - 63 IS - 2 SN - 8750-7587, 8750-7587 KW - Bronchodilator Agents KW - 0 KW - Methacholine Compounds KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Serotonin KW - 333DO1RDJY KW - Histamine KW - 820484N8I3 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Animals KW - Airway Resistance -- drug effects KW - Bronchodilator Agents -- pharmacology KW - Dose-Response Relationship, Drug KW - Dogs KW - Bronchial Spasm -- chemically induced KW - Serotonin -- pharmacology KW - Isoproterenol -- antagonists & inhibitors KW - Histamine -- pharmacology KW - Methacholine Compounds -- pharmacology KW - Isoproterenol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81026740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=In+vivo+functional+antagonism+between+isoproterenol+and+bronchoconstrictants+in+the+dog.&rft.au=Jenne%2C+J+W%3BShaughnessy%2C+T+K%3BDruz%2C+W+S%3BManfredi%2C+C+J%3BVestal%2C+R+E&rft.aulast=Jenne&rft.aufirst=J&rft.date=1987-08-01&rft.volume=63&rft.issue=2&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-09 N1 - Date created - 1987-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific antibodies to cholera toxin in rabbit milk are protective against Vibrio cholerae-induced intestinal secretion. AN - 77983232; 3443455 AB - Breast feeding helps to protect the nursing infant against infectious diarrhoeas, but the relative importance of antibodies compared with other components present in milk is unsettled. In order to aid in resolving this issue we evaluated the ability of milk, collected from rabbits not immunized or immunized enterally during pregnancy with toxinogenic, live Vibrio cholerae, to inhibit water secretion induced by V. cholerae in rat ileal loops. Non-immune milk was not inhibitory, whereas immune milk was. The inhibitory component of the immune milk was immunoglobulin by virtue of its molecular weight and absorption by an anti-rat immunoglobulin immunosorbent. In addition, the inhibitory antibodies were principally antibodies to cholera toxin because they could be removed from the milk by a cholera toxin immunosorbent but were only partially removed by incubation with whole V. cholerae. Thus, in rabbit milk, we could implicate specific antibodies in protection against intestinal water secretion induced by V. cholerae. JF - Immunology AU - Yoshiyama, Y AU - Brown, W R AD - Department of Medicine, Veterans Administration Medical Center, Denver, Colorado 80220. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 543 EP - 547 VL - 61 IS - 4 SN - 0019-2805, 0019-2805 KW - Antibodies, Bacterial KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Vibrio cholerae -- growth & development KW - Cholera -- immunology KW - Vibrio cholerae -- immunology KW - Immunity, Maternally-Acquired KW - Male KW - Immunization KW - Cholera Toxin -- immunology KW - Ileum -- secretion KW - Antibodies, Bacterial -- immunology KW - Body Water -- secretion KW - Milk -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77983232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Specific+antibodies+to+cholera+toxin+in+rabbit+milk+are+protective+against+Vibrio+cholerae-induced+intestinal+secretion.&rft.au=Yoshiyama%2C+Y%3BBrown%2C+W+R&rft.aulast=Yoshiyama&rft.aufirst=Y&rft.date=1987-08-01&rft.volume=61&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-28 N1 - Date created - 1988-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Allergy. 1983;33:106-19 [6338509] Infect Immun. 1983 Jan;39(1):147-54 [6295953] N Engl J Med. 1983 Jun 9;308(23):1389-92 [6843632] Int Arch Allergy Appl Immunol. 1984;75(2):143-8 [6469386] Pediatrics. 1985 Jan;75(1 Pt 2):172-6 [3880886] Immunology. 1985 Aug;55(4):579-83 [4018842] Int Arch Allergy Appl Immunol. 1986;79(3):270-5 [3949409] Pediatr Res. 1986 May;20(5):416-21 [3714350] J Infect Dis. 1974 Feb;129(2):117-23 [4129825] Infect Immun. 1976 Mar;13(3):735-40 [1270131] J Immunol. 1979 Oct;123(4):1705-8 [479596] Infect Immun. 1981 Jul;33(1):136-41 [7021421] Pediatr Res. 1982 Apr;16(4 Pt 1):266-71 [7043382] Infect Immun. 1982 Jun;36(3):900-6 [7047401] Infect Immun. 1983 May;40(2):563-9 [6341242] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glutathione and lymphocyte activation: a function of ageing and auto-immune disease. AN - 77974722; 3443453 AB - A decline in tissue and serum of glutathione (GSH) content and GSH-metabolizing enzymes with age has been implicated in the increasing susceptibility to carcinogens, disease and drugs which occurs with advanced age. Immunological senescence has been directly associated with increased incidence of cancer and infection with age. The auto-immune diseases of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) demonstrate depressed T-cell function together with B-cell hyperactivity. In addition, RA and SLE are chronic inflammatory conditions which have been associated with low serum and erythrocyte GSH concentrations when compared to normal. We hypothesized that augmentation of intracellular GSH concentrations in lymphocytes may enhance immune function in depressed immune states. Our data, using murine animal models for ageing (C57BL/6J) and the RA/SLE-like auto-immune diseases of the MRL/lpr mouse, indicate that intracellular glutathione of splenic lymphocytes does not decline with age or with a chronic inflammatory auto-immune disease. In contrast, immune responsiveness in splenic lymphocytes does decline. We can, however, augment both intracellular GSH concentrations and the immune response of splenic lymphocytes from animals of all ages as well as in those animals with the SLE-like auto-immune disease. JF - Immunology AU - Fidelus, R K AU - Tsan, M F AD - Research Service, Albany Veterans Administration Medical Centre, New York 12208. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 503 EP - 508 VL - 61 IS - 4 SN - 0019-2805, 0019-2805 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Mice, Inbred Strains KW - Lupus Erythematosus, Systemic -- immunology KW - Animals KW - Lymphocytes -- immunology KW - Mice KW - Lymphocytes -- analysis KW - Arthritis, Rheumatoid -- immunology KW - Lymphocyte Activation KW - Aging -- metabolism KW - Glutathione -- analysis KW - Autoimmune Diseases -- metabolism KW - Aging -- immunology KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77974722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Glutathione+and+lymphocyte+activation%3A+a+function+of+ageing+and+auto-immune+disease.&rft.au=Fidelus%2C+R+K%3BTsan%2C+M+F&rft.aulast=Fidelus&rft.aufirst=R&rft.date=1987-08-01&rft.volume=61&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-28 N1 - Date created - 1988-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1978 Feb;76(2):439-47 [10605449] Ann Intern Med. 1964 Sep;61:423-34 [14218927] Biochem Biophys Res Commun. 1975 Feb 3;62(3):651-7 [1120072] J Biochem. 1977 Jul;82(1):117-24 [893379] Cell Immunol. 1978 Mar 15;36(2):303-11 [630610] J Exp Med. 1978 Nov 1;148(5):1198-215 [309911] Lancet. 1979 Nov 24;2(8152):1126-7 [91852] J Rheumatol Suppl. 1981 Jan-Feb;7:14-9 [6785436] Ann Rheum Dis. 1981 Jun;40(3):293-8 [7247473] J Immunol. 1981 Dec;127(6):2257-62 [6975313] Cell Immunol. 1982 Jan 15;66(2):372-82 [6461422] Science. 1983 Apr 29;220(4596):472-7 [6836290] Biochem Pharmacol. 1983 Apr 15;32(8):1383-8 [6860357] J Immunol. 1984 Mar;132(3):1462-5 [6229581] Clin Immunol Immunopathol. 1984 Apr;31(1):109-17 [6421522] Immunology. 1984 Apr;51(4):801-8 [6231244] Gen Pharmacol. 1984;15(3):267-70 [6735142] Clin Exp Immunol. 1984 Jul;57(1):123-9 [6611230] Proc Natl Acad Sci U S A. 1984 Aug;81(15):4732-5 [6146978] Biochem Biophys Res Commun. 1984 Sep 17;123(2):626-32 [6487304] Gerontology. 1984;30(5):279-89 [6386608] Biochem Biophys Res Commun. 1985 Feb 28;127(1):270-6 [3977922] J Immunol. 1985 Oct;135(4):2740-7 [4031498] Cell Immunol. 1986 Jan;97(1):155-63 [3742607] Anal Biochem. 1969 Mar;27(3):502-22 [4388022] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Systemic photoprotective agents. AN - 77935371; 3324073 AB - The concept of an effective, safe systemic photoprotectant circumvents many of the shortcomings associated with the use of topical agents as a modality preventive of actinic damage. On the other hand, difficulties resulting from systemic metabolism and toxicity complicate this approach. The problems are exemplified by the fact that some agents such as the antimalarials, psoralens, and carotenoids have been successfully employed in the treatment of specific photosensitive diseases but, aside from any potential toxicities, their ameliorative effects appear to be related to the particular pathomechanisms of the responding disease rather than general photoprotection. The complexity of systemic approaches is further demonstrated by the fact that agents possessing protective properties, e.g. butylated hydroxytoluene and carotenoids, inhibit UV carcinogenesis, while others, e.g., 8-methoxypsoralen, potentiate this process. Nevertheless, from this ostensible disorder of responses, it seems apparent that those agents holding the greatest promise for future investigation are those capable of enhancing natural defense mechanisms, i.e., melanization and antiradical activity. Thus, while none of the agents reviewed here are deemed suitable as general photoprotectants, the fact that only a modest, measured protective effect can elicit a dramatic decrease in actinic damage (particularly with respect to cancer) upholds this concept as an important goal. JF - Photo-dermatology AU - Black, H S AD - Photobiology Laboratory, Veterans Administration Medical Center, Houston, Texas. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 187 EP - 195 VL - 4 IS - 4 SN - 0108-9684, 0108-9684 KW - Radiation-Protective Agents KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- drug effects KW - Radiation-Protective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77935371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photo-dermatology&rft.atitle=Systemic+photoprotective+agents.&rft.au=Black%2C+H+S&rft.aulast=Black&rft.aufirst=H&rft.date=1987-08-01&rft.volume=4&rft.issue=4&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Photo-dermatology&rft.issn=01089684&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of prophylactic rabbit antithymocyte globulin in cardiac allograft recipients treated with cyclosporine. AN - 81064603; 3312532 AB - The prophylactic use of rabbit antithymocyte globulin (RATG) was evaluated in 13 cardiac allograft recipients who received a low-dose of RATG (175 +/- 32 mg) after transplantation (group 1). The patients were retrospectively compared with 13 parallel cases receiving the same treatment except for the initial RATG (group 2). There were no differences in the patient composition and the level of the basic immunosuppression therapy with cyclosporine. The patients treated with RATG (group 1) showed substantially greater suppression of T helper and total T cells up to 10 and 20 days after surgery, respectively. The incidence of rejection episodes during the initial admission seemed lower in patients receiving RATG, with a borderline significance (1.4 versus 2.4, p = 0.06). This accounts for the reduced requirement of methylprednisolone in treating rejection in patients in group 1 (1.3 gm versus 4.0 gm, p less than 0.02). Moreover, the patients without initial doses of RATG (group 2) more frequently experienced recurrent rejection (five of 12 versus nine of 10, p less than 0.05), which necessitated rescue RATG; the initial difference in the RATG usage disappeared by the time of discharge. Serious infection occurring after antirejection therapy was common in the group 2 patients without initial doses of RATG, although the overall incidence of infection was not statistically different. Prophylactic use of RATG at the dosage used appeared to reduce the incidence of rejection and the requirement for intravenous steroids and other immunosuppressants. It seems warranted to test this approach in a prospective randomized manner. JF - The Journal of heart transplantation AU - Kawaguchi, A AU - Szentpetery, S AU - Mohanakumar, T AU - Barnhart, G R AU - Lower, R R AD - McGuire Veterans Administration Medical Center, Richmond, Virginia. PY - 1987 SP - 214 EP - 217 VL - 6 IS - 4 SN - 0887-2570, 0887-2570 KW - Antibodies, Monoclonal KW - 0 KW - Antilymphocyte Serum KW - Cyclosporins KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Retrospective Studies KW - Rabbits KW - Middle Aged KW - Male KW - Immunosuppression KW - Antibodies, Monoclonal -- immunology KW - T-Lymphocytes -- classification KW - Cyclosporins -- adverse effects KW - Heart Transplantation KW - Antilymphocyte Serum -- pharmacology KW - Graft Rejection -- drug effects KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81064603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+heart+transplantation&rft.atitle=Effects+of+prophylactic+rabbit+antithymocyte+globulin+in+cardiac+allograft+recipients+treated+with+cyclosporine.&rft.au=Kawaguchi%2C+A%3BSzentpetery%2C+S%3BMohanakumar%2C+T%3BBarnhart%2C+G+R%3BLower%2C+R+R&rft.aulast=Kawaguchi&rft.aufirst=A&rft.date=1987-07-01&rft.volume=6&rft.issue=4&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+heart+transplantation&rft.issn=08872570&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-27 N1 - Date created - 1987-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - On professional therapists and Alcoholics Anonymous. AN - 77893442; 3121828 JF - Journal of psychoactive drugs AU - Clark, H W AD - Alcohol Inpatient Unit, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1987 SP - 233 EP - 242 VL - 19 IS - 3 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - Models, Psychological KW - Mental Disorders -- therapy KW - Interinstitutional Relations KW - Humans KW - Cost-Benefit Analysis KW - Philosophy KW - Counseling KW - Professional-Patient Relations KW - Female KW - Psychotherapy KW - Alcoholism -- therapy KW - Alcoholics Anonymous KW - Alcoholism -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77893442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=On+professional+therapists+and+Alcoholics+Anonymous.&rft.au=Clark%2C+H+W&rft.aulast=Clark&rft.aufirst=H&rft.date=1987-07-01&rft.volume=19&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 12-step study groups in drug abuse treatment programs. AN - 77888379; 3694333 JF - Journal of psychoactive drugs AU - Muhleman, D AD - Alcohol Outpatient Clinic, Veterans Administration Medical Center, San Francisco, California 94121. PY - 1987 SP - 291 EP - 298 VL - 19 IS - 3 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - California KW - Identification (Psychology) KW - Cognition Disorders -- etiology KW - Humans KW - Affect KW - Self-Help Groups KW - Alcoholism -- complications KW - Hospitals, Veterans KW - Substance-Related Disorders -- therapy KW - Psychotherapy, Group -- methods KW - Counseling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77888379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=12-step+study+groups+in+drug+abuse+treatment+programs.&rft.au=Muhleman%2C+D&rft.aulast=Muhleman&rft.aufirst=D&rft.date=1987-07-01&rft.volume=19&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hyperactivity and the Risk for Alcoholism AN - 61547286; 198802149 AB - Questionnaire data from 32 adult sons of alcholics & 32 controls (students/staff at the U of California, San Diego) regarding childhood & adult symptoms of hyperactivity revealed no significant family group differences on any of the 48 childhood items examined or on 3 scales constructed from those questions. The 2 groups differed significantly on only 3 of the 56 items regarding adult or residual hyperactivity & on only 1 of 7 possible adult scales, with alcoholics' sons tending to report more evidence of a hot temper & a short attention span. Using DSM-III criteria, it is found that 2 (6%) of the alcoholics' sons & 4 (12%) of the controls fulfilled criteria for attention deficit disorder (ADD) with hyperactivity in childhood, but none met the criteria for ADD, residual type, in adulthood. Thus, the findings do not indicate an elevated risk for ADD in the sons of alcoholics. 1 Table, 20 References. HA JF - The Journal of Clinical Psychiatry AU - Schuckit, Marc Alan AU - Sweeney, Susan AU - Huey, Leighton AD - San Diego Veterans Administration Medical Center, 3350 La Jolla Village Dr CA 92161 Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 275 EP - 277 VL - 48 IS - 7 SN - 0160-6689, 0160-6689 KW - hyperactivity, adult sons of alcoholic/nonalcoholic fathers KW - questionnaires KW - Family Relations KW - Generational Differences KW - Alcoholism KW - Parent Child Relations KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61547286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Clinical+Psychiatry&rft.atitle=Hyperactivity+and+the+Risk+for+Alcoholism&rft.au=Schuckit%2C+Marc+Alan%3BSweeney%2C+Susan%3BHuey%2C+Leighton&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1987-07-01&rft.volume=48&rft.issue=7&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Clinical+Psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Alcoholism; Parent Child Relations; Family Relations; Generational Differences ER - TY - JOUR T1 - Health and Hassles in Older and Younger Men AN - 61474644; 198800740 AB - A comparison of hassles & uplifts in older (aged 65+) & younger (aged 45-64) chronically ill Ms in regard to whether they perceived their health as good or poor, based on scale data collected in Miami, Fla, in 1984/85 (N = 50). Hassles are irritating & frustrating demands (minor stresses) that characterize everyday transactions with the environment, eg, losing things or being in traffic jams; uplifts are positive events that could help counteract the effects of stress. Multivariate analysis of variance reveals that uplifts did not discriminate significantly between ages or health perceptions. Hassles were also similar between old & young, but those who viewed their health as poor reported more hassles, mostly from events that were related to their physical health care. Because of the confounding effects with health in individuals who are already ill, hassles may not be good predictors of future health status, but they can help health professionals understand the kinds of demands that produce stress in management of diseases. 2 Tables, 21 References. Modified HA JF - Journal of Clinical Psychology AU - Ewedemi, Funke AU - Linn, Margaret W AD - c/o Linn -- Veterans Administration Medical Center, 1201 NW 16 St Miami FL 33125 Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 347 EP - 353 VL - 43 IS - 4 SN - 0021-9762, 0021-9762 KW - personal health perceptions, younger vs older chronically ill men, Miami, Florida KW - hassles, uplifts KW - scales KW - 1984/85 KW - Perceptions KW - Chronic Illness KW - Males KW - Florida KW - Age Differences KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61474644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Health+and+Hassles+in+Older+and+Younger+Men&rft.au=Ewedemi%2C+Funke%3BLinn%2C+Margaret+W&rft.aulast=Ewedemi&rft.aufirst=Funke&rft.date=1987-07-01&rft.volume=43&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Chronic Illness; Age Differences; Males; Perceptions; Florida ER - TY - JOUR T1 - Accurate Reading by Nonlexical Means: A Case Study AN - 58183405; 8706440 AB - It has generally been assumed that accurate reading of irregular words depends on intact lexical reading mechanisms. This type of processing has been considered impossible using a nonlexical mechanism. However, no adequate evaluation has been made of the level of accuracy attainable using nonlexical access. The reading of regular & irregular words by an adult M with impaired lexical reading mechanisms resulting from a stroke was examined. Overall reading ability was assessed using the Wide Range Achievement Test (WRAT). Six additional word lists were used to examine specific aspects of reading: (1) a list varying word length & frequency, (2) a list with high & low imageability words, (3) a list of content & function words, (4)-(6) lists of matched pairs of regularly & irregularly spelled words. Also examined were reading of nonwords, single word comprehension, & lexical decision ability. To evaluate the possibility that the patient was using a nonlexical reading strategy, two tests designed to subvert this strategy were used. In the first, words having a single correct pronunciation as well as a plausible mispronunciation which also formed a real word were presented for reading. In the second, a list of pronounceable nonwords in which real words were embedded was presented. This S showed a high level of reading accuracy in comparison with previously reported cases of surface dyslexia, & appears to have a relatively intact nonlexical reading mechanism, accompanied by an excellent & effectively referenced speaking vocabulary. 3 Tables, 27 References. B. Annesser Murray JF - Brain and Language AU - Katz, Robert B AU - Sevush, Steven AD - Psychology Service Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 252 EP - 266 VL - 31 IS - 2 SN - 0093-934X, 0093-934X KW - regular/irregular word reading accuracy KW - nonlexical reading strategy KW - adult stroke patient KW - Reading Processes (re6) KW - Cognitive Processes (co1b) KW - Reading Deficiency (re3) KW - Reading Comprehension (re2b) KW - Nervous System Pathology (ne3) KW - article KW - 4119: applied linguistics; reading processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58183405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Accurate+Reading+by+Nonlexical+Means%3A+A+Case+Study&rft.au=Katz%2C+Robert+B%3BSevush%2C+Steven&rft.aulast=Katz&rft.aufirst=Robert&rft.date=1987-07-01&rft.volume=31&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Reading Processes (re6); Cognitive Processes (co1b); Nervous System Pathology (ne3); Reading Comprehension (re2b); Reading Deficiency (re3) ER - TY - JOUR T1 - In vivo and in vitro activity of ciprofloxacin plus azlocillin against 12 streptococcal isolates in a neutropenic site model. AN - 81013582; 3115671 AB - Closed-space neutropenic infection sites were simulated in rabbits by subcutaneous semipermeable chambers that were inoculated with 5 X 10(4) CFU/ml of various strains of Streptococcus pneumoniae, Streptococcus faecalis, and Streptococcus avium. Four hours after inoculation, treatment was begun with ciprofloxacin, 10 or 30 mg/kg, azlocillin, 100 mg/kg, amikacin, 15 mg/kg, procaine penicillin G, 300 U/dose, or gentamicin, 2 mg/kg, alone and in two-drug combinations. Antimicrobials were given intramuscularly every 6 hr for 16 doses. Extravascular chambers were sampled throughout the treatment course for bacterial counts and antimicrobial concentration. In vivo results were compared to in vitro tests of inhibition, killing, and synergism. Ciprofloxacin alone had little effect on the animal infection sites. Azlocillin alone reduced, in vivo, eight of 12 isolates greater than or equal to 5 log10 CFU/ml by 92 hr as compared to control. Azlocillin plus ciprofloxacin reduced all 12 isolates greater than or equal to 5 log10 CFU/ml by 92 hr, whereas amikacin plus azlocillin reduced only three and penicillin plus gentamicin only one of the six group D streptococcal isolates greater than or equal to 5 log10 CFU/ml. JF - Diagnostic microbiology and infectious disease AU - Peterson, L R AU - Moody, J A AU - Fasching, C E AU - Gerding, D N AD - Medical Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 127 EP - 136 VL - 7 IS - 2 SN - 0732-8893, 0732-8893 KW - Gentamicins KW - 0 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Amikacin KW - 84319SGC3C KW - Azlocillin KW - HUM6H389W0 KW - Penicillin G KW - Q42T66VG0C KW - Index Medicus KW - Animals KW - Neutropenia -- complications KW - Penicillin G -- pharmacology KW - Disease Models, Animal KW - Rabbits KW - Enterococcus faecalis -- drug effects KW - Streptococcus pneumoniae -- drug effects KW - Amikacin -- pharmacology KW - Drug Therapy, Combination KW - Kinetics KW - Gentamicins -- therapeutic use KW - Penicillin G -- therapeutic use KW - Amikacin -- therapeutic use KW - Drug Synergism KW - Female KW - Gentamicins -- pharmacology KW - Ciprofloxacin -- pharmacology KW - Azlocillin -- pharmacology KW - Ciprofloxacin -- therapeutic use KW - Streptococcus -- drug effects KW - Streptococcal Infections -- drug therapy KW - Azlocillin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81013582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+microbiology+and+infectious+disease&rft.atitle=In+vivo+and+in+vitro+activity+of+ciprofloxacin+plus+azlocillin+against+12+streptococcal+isolates+in+a+neutropenic+site+model.&rft.au=Peterson%2C+L+R%3BMoody%2C+J+A%3BFasching%2C+C+E%3BGerding%2C+D+N&rft.aulast=Peterson&rft.aufirst=L&rft.date=1987-06-01&rft.volume=7&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Diagnostic+microbiology+and+infectious+disease&rft.issn=07328893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-16 N1 - Date created - 1987-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Follow-Up of Pathological Gamblers after Treatment AN - 61590975; 198702146 AB - Pathological gamblers entering a comprehensive treatment program were thoroughly assessed before treatment & 6 months after completion of treatment. The reports of gamblers & collateral informants were highly consistent. Follow-up interviews were conducted with 57 of the 66 patients entering treatment. Total abstinence was reported by 56% (N = 32) of the patients located for follow-up, & significant improvement on a wide range of measures was documented. It is felt that the results demonstrate that pathological gambling is a treatable mental disorder. 2 Tables, 23 References. HA JF - The American Journal of Psychiatry AU - Taber, Julian I AU - McCormick, Richard A AU - Russo, Angel M AU - Adkins, Bonnie J AU - Ramirez, Luis F AD - c/o McCormick -- Cleveland Veterans Administration Center, 10000 Brecksville Rd Brecksville OH 44141 Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 757 EP - 761 VL - 144 IS - 6 SN - 0002-953X, 0002-953X KW - pathological gambling, treatment outcomes KW - interviews KW - Gambling KW - Treatment Programs KW - Program Evaluation KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Follow-Up+of+Pathological+Gamblers+after+Treatment&rft.au=Taber%2C+Julian+I%3BMcCormick%2C+Richard+A%3BRusso%2C+Angel+M%3BAdkins%2C+Bonnie+J%3BRamirez%2C+Luis+F&rft.aulast=Taber&rft.aufirst=Julian&rft.date=1987-06-01&rft.volume=144&rft.issue=6&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Gambling; Treatment Programs; Program Evaluation ER - TY - JOUR T1 - Dementia in an American-Chinese Nursing Home Population AN - 61590853; 198701968 AB - Of 58 demented residents in an American-Chinese nursing home, 44 (75.9%) had multi-infarct dementia, 7 (12.1%) had possible Alzheimer's disease, 4 (6.9%) had other dementias, & 3 (5.2%) had unknown disorders. Alzheimer's disease was relatively less prevalent than in US nursing homes overall. 10 References. HA JF - The American Journal of Psychiatry AU - Serby, Michael AU - Chou, James C.-Y. AU - Franssen, Emile H AD - Veterans Administration Medical Center, 408 First Ave New York NY 10010 Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 811 EP - 812 VL - 144 IS - 6 SN - 0002-953X, 0002-953X KW - dementia, American-Chinese nursing home residents KW - case records KW - Asian Cultural Groups KW - Psychosis KW - Senility KW - Elderly KW - United States of America KW - Mental Illness KW - Nursing Homes KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Dementia+in+an+American-Chinese+Nursing+Home+Population&rft.au=Serby%2C+Michael%3BChou%2C+James+C.-Y.%3BFranssen%2C+Emile+H&rft.aulast=Serby&rft.aufirst=Michael&rft.date=1987-06-01&rft.volume=144&rft.issue=6&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States of America; Nursing Homes; Psychosis; Mental Illness; Elderly; Senility; Asian Cultural Groups ER - TY - JOUR T1 - Psychological and Interpersonal Issues in Space AN - 60998583; 88T5206 AB - As future manned space missions become longer, & as crews become more heterogeneous, psychological & interpersonal factors will take on increasing importance in assuring mission success. On the basis of a review of 60+ US & Soviet space simulation studies on Earth, along with reports from US & Soviet space missions, 9 psychological & 7 interpersonal issues are discussed along with pertinent research findings & examples from manned spaceflights. Suggestions are offered for further psychological & interpersonal research should be done under actual spaceflight conditions. 55 References. HA JF - The American Journal of Psychiatry AU - Kanas, Nick AD - Psychiatry Service Veterans Administration, 4150 Clement St San Francisco CA 94121 Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 703 EP - 709 VL - 144 IS - 6 SN - 0002-953X, 0002-953X KW - manned space missions, psychological/interpersonal issues KW - literature review KW - US/USSR space simulation studies KW - Interpersonal Relations KW - Space Technology KW - article KW - 2656: environmental interactions; environmental interactions KW - 2454: policy, planning, forecasting; planning & forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60998583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Psychological+and+Interpersonal+Issues+in+Space&rft.au=Kanas%2C+Nick&rft.aulast=Kanas&rft.aufirst=Nick&rft.date=1987-06-01&rft.volume=144&rft.issue=6&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Space Technology; Interpersonal Relations ER - TY - JOUR T1 - Brain Mechanisms and Social/Affective Behavior AN - 60931954; 87T0362 AB - An analysis of experimental evidence from laboratory & field studies on monkeys demonstrate that the amygdaloid nuclei & its afferent cortical areas of the temporal pole & posterior orbital cortex are essential for the maintenance of social bondings & affiliative behavior in nonhuman primates. The degree of deficit in affiliative behavior, following ablation of these structures, is dependent on social & environmental factors such that the more complex the social group &/or environment, the greater the deficit in affiliative behavior extending to social isolation in natural settings. Electrical recordings from the amygdaloid nuclei demonstrate a hierarchy of activity that is correlated with the emotional significance of external stimuli. Ablation of those cortical areas having an influence on social behavior also profoundly affect the electrical activity of the amygdala. However, those structures that project to the amygdala that do not grossly affect affiliative behavior may influence interpretation of external stimuli. A case of a human patient who sustained a partial amygdalectomy is reported, that supports the importance of the amygdaloid nuclei in the regulation of social/affective behavior in man. 8 References. AA JF - Social Science Information/Information sur les Sciences Sociales AU - Kling, Arthur Shaw AD - Psychiatry Service Veterans Administration Medical Center 116A, 16111 Plummer St Sepulveda CA 91343 Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 375 EP - 384 VL - 26 IS - 2 SN - 0539-0184, 0539-0184 KW - social bondings/affiliative behavior, brain mechanisms' role KW - experiments KW - monkeys KW - Affiliation Need KW - Social Behavior KW - article KW - 1844: demography and human biology; human biology/sociobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60931954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+Information%2FInformation+sur+les+Sciences+Sociales&rft.atitle=Brain+Mechanisms+and+Social%2FAffective+Behavior&rft.au=Kling%2C+Arthur+Shaw&rft.aulast=Kling&rft.aufirst=Arthur&rft.date=1987-06-01&rft.volume=26&rft.issue=2&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Social+Science+Information%2FInformation+sur+les+Sciences+Sociales&rft.issn=05390184&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCIBL N1 - SubjectsTermNotLitGenreText - Social Behavior; Affiliation Need ER - TY - JOUR T1 - Atrial natriuretic factor and sodium nitroprusside increase cyclic GMP in cultured rat lung fibroblasts by activating different forms of guanylate cyclase. AN - 81056677; 2889449 AB - We used cultured rat lung fibroblasts to evaluate the role of particulate and soluble guanylate cyclase in the atrial natriuretic factor (ANF)-induced stimulation of cyclic GMP. ANF receptors were identified by binding of 125I-ANF to confluent cells at 37 degrees C. Specific ANF binding was rapid and saturable with increasing concentrations of ANF. The equilibrium dissociation constant (KD) was 0.66 +/- 0.077 nM and the Bmax. was 216 +/- 33 fmol bound/10(6) cells, which corresponds to 130,000 +/- 20,000 sites/cell. The molecular characteristics of ANF binding sites were examined by affinity cross-linking of 125I-ANF to intact cells with disuccinimidyl suberate. ANF specifically labelled two sites with molecular sizes of 66 and 130 kDa, which we have identified in other cultured cells. ANF and sodium nitroprusside produced a time- and concentration-dependent increase in intracellular cyclic GMP. An increase in cyclic GMP by ANF was detected at 1 nM, and at 100 nM an approx. 100-fold increase in cyclic GMP was observed. Nitroprusside stimulated cyclic GMP at 10 nM and at 1 mM a 500-600-fold increase in cyclic GMP occurred. The simultaneous addition of 100 nM-ANF and 10 microM-nitroprusside to cells resulted in cyclic GMP levels that were additive. ANF increased the activity of particulate guanylate cyclase by about 10-fold, but had no effect on soluble guanylate cyclase. In contrast, nitroprusside did not alter the activity of particulate guanylate cyclase, but increased the activity of soluble guanylate cyclase by 17-fold. These results demonstrate that rat lung fibroblasts contain ANF receptors and suggest that the ANF-induced stimulation of cyclic GMP is mediated entirely by particulate guanylate cyclase. JF - The Biochemical journal AU - Leitman, D C AU - Agnost, V L AU - Tuan, J J AU - Andresen, J W AU - Murad, F AD - Department of Medicine, Stanford University School of Medicine, Veterans Administration Medical Center, Palo Alto, CA 94304. Y1 - 1987/05/15/ PY - 1987 DA - 1987 May 15 SP - 69 EP - 74 VL - 244 IS - 1 SN - 0264-6021, 0264-6021 KW - Ferricyanides KW - 0 KW - atrial natriuretic peptide, rat KW - Nitroprusside KW - 169D1260KM KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Rats KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Cells, Cultured KW - Enzyme Activation -- drug effects KW - Drug Synergism KW - Fibroblasts -- metabolism KW - Guanylate Cyclase -- metabolism KW - Ferricyanides -- pharmacology KW - Cyclic GMP -- metabolism KW - Atrial Natriuretic Factor -- pharmacology KW - Nitroprusside -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81056677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Atrial+natriuretic+factor+and+sodium+nitroprusside+increase+cyclic+GMP+in+cultured+rat+lung+fibroblasts+by+activating+different+forms+of+guanylate+cyclase.&rft.au=Leitman%2C+D+C%3BAgnost%2C+V+L%3BTuan%2C+J+J%3BAndresen%2C+J+W%3BMurad%2C+F&rft.aulast=Leitman&rft.aufirst=D&rft.date=1987-05-15&rft.volume=244&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] N Engl J Med. 1985 Nov 21;313(21):1330-40 [2932646] Biochem Biophys Res Commun. 1984 Jun 29;121(3):855-62 [6540085] Endocrinology. 1984 Oct;115(4):1636-8 [6090110] Proc Natl Acad Sci U S A. 1984 Oct;81(19):5946-50 [6091122] Am J Physiol. 1984 Nov;247(5 Pt 2):F863-6 [6238539] J Biol Chem. 1984 Dec 10;259(23):14332-4 [6150043] Life Sci. 1984 Dec 3;35(23):2311-8 [6094938] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661-4 [6150486] Biochem Biophys Res Commun. 1984 Dec 14;125(2):562-8 [6097241] Biochem Biophys Res Commun. 1985 Mar 15;127(2):433-42 [2983720] Neuroendocrinology. 1985 Mar;40(3):277-9 [3157876] Biochim Biophys Acta. 1985 May 30;845(2):298-303 [2859896] Endocr Rev. 1985 Spring;6(2):107-27 [2988929] J Biol Chem. 1985 Sep 15;260(20):10889-92 [2993293] FEBS Lett. 1986 Jan 6;194(2):210-4 [2866981] J Clin Invest. 1985 Dec;76(6):2041-8 [3001138] J Clin Invest. 1985 Dec;76(6):2049-56 [3001139] Proc Natl Acad Sci U S A. 1985 Dec;82(24):8720-3 [2934736] Proc Natl Acad Sci U S A. 1986 Jan;83(1):174-8 [3001722] Biochim Biophys Acta. 1986 Jan 23;885(1):74-9 [2867788] J Biol Chem. 1986 Feb 5;261(4):1525-8 [3003074] Endocrinology. 1986 Apr;118(4):1726-8 [2936598] N Engl J Med. 1986 Mar 27;314(13):828-34 [2936957] Biochem Biophys Res Commun. 1986 Mar 13;135(2):515-20 [2938578] J Biol Chem. 1986 May 5;261(13):5817-23 [2871018] Am J Physiol. 1986 May;250(5 Pt 2):H871-8 [2939731] J Biol Chem. 1986 Jun 5;261(16):7236-41 [2872214] Circ Res. 1986 Mar;58(3):407-10 [3013461] J Clin Invest. 1986 Jul;78(1):1-5 [2873150] Proc Natl Acad Sci U S A. 1986 Jul;83(13):4769-73 [3014509] J Biol Chem. 1986 Sep 5;261(25):11650-5 [3017939] Trans Assoc Am Physicians. 1985;98:243-52 [3022442] Anal Biochem. 1981 Oct;117(1):136-46 [7316186] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A 52-week comparison of lisinopril, hydrochlorothiazide, and their combination in hypertension. AN - 77866426; 2826549 AB - Lisinopril is a long-acting converting-enzyme inhibitor. A 52-week study was undertaken to compare the antihypertensive efficacy and safety of lisinopril, hydrochlorothiazide (HCTZ), and a combination of the two drugs in 24 patients with a sitting diastolic blood pressure (DBP) of 90 to 120 mm Hg. After a four-week single-blind placebo-washout phase, ten patients received lisinopril, ten received HCTZ, and four received the combination in increasing doses in a double-blind fashion for the next 12 weeks. The target blood pressure was less than 90 mm Hg DBP and a decrease of at least 10 mm Hg. For the next 12 weeks, the responders continued to receive the same medications; however, the nonresponders from the two groups received the combination, increasing the number of patients receiving both to 13. The DBP was controlled in eight of the ten patients with lisinopril, three of the ten patients with HCTZ, and 11 of 13 (four original and nine nonresponders) with the combination. For the next 28 weeks, 17 patients agreed to continue into a single-blind phase, during which blood pressure was controlled in six of the seven patients who were treated with lisinopril alone and nine of ten who received the combination. The heart rate rose significantly in the HCTZ-treated patients during the short-term treatment and decreased significantly in those treated with lisinopril during the long-term phase. Side effects were more frequent in patients receiving the combination but were always mild and subsided spontaneously. Lisinopril appeared to be more effective than HCTZ as a step-1 drug, and the combination was superior to either agent alone. JF - Journal of clinical pharmacology AU - Kochar, M S AU - Bolek, G AU - Kalbfleisch, J H AU - Olzinski, P AD - Medical Service of the Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI. PY - 1987 SP - 373 EP - 377 VL - 27 IS - 5 SN - 0091-2700, 0091-2700 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Triglycerides KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Enalapril KW - 69PN84IO1A KW - Cholesterol KW - 97C5T2UQ7J KW - Lisinopril KW - E7199S1YWR KW - Index Medicus KW - Triglycerides -- blood KW - Cholesterol -- blood KW - Heart Rate -- drug effects KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Body Weight -- drug effects KW - Clinical Trials as Topic KW - Middle Aged KW - Blood Pressure -- drug effects KW - Hypertension -- physiopathology KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Enalapril -- therapeutic use KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Hydrochlorothiazide -- therapeutic use KW - Enalapril -- analogs & derivatives KW - Enalapril -- adverse effects KW - Hypertension -- drug therapy KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77866426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=A+52-week+comparison+of+lisinopril%2C+hydrochlorothiazide%2C+and+their+combination+in+hypertension.&rft.au=Kochar%2C+M+S%3BBolek%2C+G%3BKalbfleisch%2C+J+H%3BOlzinski%2C+P&rft.aulast=Kochar&rft.aufirst=M&rft.date=1987-05-01&rft.volume=27&rft.issue=5&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS and the Geriatrician AN - 61015044; 88U0726 AB - Centers for Disease Control data indicate that 10% of acquired immune deficiency syndrome (AIDS) cases are in persons aged 50+ years with 25% of these cases in persons aged 60+, & 4% in persons aged 70+. If the present age distribution holds, there will be 27,000 AIDS cases in persons aged 50+, & 1,100 cases in persons aged 70+, by 1991. Older persons are more likely to acquire AIDS through blood transfusions than via homosexual exposure or drug abuse. Thus, changes in the management of blood products will benefit older persons. The nearly 1 million elderly homosexual Ms, who have been sheltered from the virus by their sexual activity patterns, will face greater risks as the prevalence of the virus & the age of carriers increase. The underappreciated neurological consequences of human T-cell lymphotrophic virus type III (HTLV-III) infection, subacute encephalitis, vacuolar myelopathy, & psychiatric disorders will be of particular interest to geriatricians who are often consulted to evaluate neurological dysfunction. Geriatricians will need to become familiar with the spectrum of HTLV-III infection in order to counsel patients & extended-care facilities. 1 Table, 47 References. Modified HA JF - Journal of the American Geriatrics Society AU - Moss, Robert J AU - Miles, Steven H AD - Geriatric Research Education & Clinical Center Veterans Administration Medical Center (11G), 54th St & 48th Ave South Minneapolis MN 55417 Y1 - 1987/05// PY - 1987 DA - May 1987 SP - 460 EP - 464 VL - 35 IS - 5 SN - 0002-8614, 0002-8614 KW - acquired immune deficiency syndrome, older persons KW - official data KW - Acquired Immune Deficiency Syndrome KW - Elderly KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61015044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=AIDS+and+the+Geriatrician&rft.au=Moss%2C+Robert+J%3BMiles%2C+Steven+H&rft.aulast=Moss&rft.aufirst=Robert&rft.date=1987-05-01&rft.volume=35&rft.issue=5&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Elderly; Acquired Immune Deficiency Syndrome ER - TY - JOUR T1 - Small Town Streets and Country Lanes AN - 61611779; 198801639 AB - A description of a social worker's 1984 caseload of adult foster care residents & managers in a Ru & small town setting in southern Ohio under the auspices of the Chillicothe, Ohio, Veterans Administration (VA) Medical Center. The VA residential care program & the Ru area in which it is implemented are described. Of a caseload of 106 residents, 45 remained in the program & 61 changed location, were rehospitalized, or left the program for other reasons. Surprisingly, residents with psychiatric diagnoses accounted for 55% of the hospitalizations for medical reasons. The mean age of residents was 58 & their average monthly payment was $377 for their care & support in the homes. The home managers were mostly F & took a protective attitude toward the residents, whom they tended to view as family members. 10 References. Modified HA JF - Adult Foster Care Journal AU - Miller, Mark C AD - Veterans Administration Medical Center, Chillicothe OH 45601 Y1 - 1987/04// PY - 1987 DA - April 1987 SP - 56 EP - 65 VL - 1 IS - 1 KW - adult foster care, rural/small town Ohio KW - case records KW - Veterans Administration social worker's caseload KW - 1984 KW - Adults KW - Foster Care KW - Rural Areas KW - Towns KW - Ohio KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61611779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adult+Foster+Care+Journal&rft.atitle=Small+Town+Streets+and+Country+Lanes&rft.au=Miller%2C+Mark+C&rft.aulast=Miller&rft.aufirst=Mark&rft.date=1987-04-01&rft.volume=1&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Adult+Foster+Care+Journal&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Foster Care; Adults; Towns; Ohio; Rural Areas ER - TY - JOUR T1 - Legionnaires ' Disease Acquired Within the Homes of Two Patients , Link to the Home Water Supply AN - 19026717; 8807070 AB - Two patients with sporadic community-acquired legionnaires ' disease are described. Legionella pneumophila was isolated from sputum specimens, and seroconversion of antibody titers was demonstrated for both patients. Legionella pneumophila was also recovered from the residential water supply of both patients. In each case, the serogroup of the environmental organism matched that of the infecting organism. In one patient, serogroup 3 was isolated - a rare cause of legionnaires ' disease, and in the second case, monoclonal antibody testing confirmed that the serogroup 1 organisms isolated from sputum and residential water supply samples were identical. The incubation period of legionnaires ' disease is presumed to be up to two weeks. Because of medical problems, both patients had been confined to their homes for the entire two weeks before the onset of symptoms. This is the first report that links acquisition of community-acquired legionnaires ' disease to contaminated water supplies within the homes of susceptible patients. (Author 's abstract) JF - Journal of the American Medical Association JAMAA Vol. 257, No. 9, p 1215-1217, March 1987. 24 ref. AU - Stout, JE AU - Yu, V L AU - Muraca, P AD - Infectious Disease and Special Pathogens Section Veterans Administration Medical Center Y1 - 1987/03// PY - 1987 DA - Mar 1987 KW - Water Resources Abstracts KW - Water supply KW - Legionnaire 's disease KW - Pathogens KW - Water pollution effects KW - Population exposure KW - Epidemiology KW - Public health KW - Legionella KW - Domestic water supply KW - Pollutant identification KW - Immunology KW - SW 3060:Water treatment and distribution KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19026717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Legionnaires+%27+Disease+Acquired+Within+the+Homes+of+Two+Patients+%2C+Link+to+the+Home+Water+Supply&rft.au=Stout%2C+JE%3BYu%2C+V+L%3BMuraca%2C+P&rft.aulast=Stout&rft.aufirst=JE&rft.date=1987-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Mechanisms of cyclosporine A hypertension. AN - 78058780; 3079020 JF - Transplantation proceedings AU - Lustig, S AU - Stern, N AU - Lee, D B AU - Berger, M E AU - Eggena, P AU - Balabanian, M AU - Golub, M S AD - Medical Service, Veterans Administration Medical Center, Sepulveda, CA. Y1 - 1987/02// PY - 1987 DA - February 1987 SP - 1262 EP - 1264 VL - 19 IS - 1 Pt 2 SN - 0041-1345, 0041-1345 KW - Cyclosporins KW - 0 KW - Aldosterone KW - 4964P6T9RB KW - Captopril KW - 9G64RSX1XD KW - Renin KW - EC 3.4.23.15 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Muscle, Smooth, Vascular -- physiology KW - Animals KW - Reference Values KW - Rats, Inbred SHR KW - Arteries -- innervation KW - Norepinephrine -- pharmacology KW - Muscle, Smooth, Vascular -- drug effects KW - Arteries -- physiology KW - Mice KW - Electric Stimulation KW - Captopril -- pharmacology KW - Renin -- blood KW - Rats KW - In Vitro Techniques KW - Vasoconstriction -- drug effects KW - Arteries -- drug effects KW - Blood Pressure -- drug effects KW - Muscle, Smooth, Vascular -- innervation KW - Aldosterone -- blood KW - Male KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Cyclosporins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78058780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Mechanisms+of+cyclosporine+A+hypertension.&rft.au=Lustig%2C+S%3BStern%2C+N%3BLee%2C+D+B%3BBerger%2C+M+E%3BEggena%2C+P%3BBalabanian%2C+M%3BGolub%2C+M+S&rft.aulast=Lustig&rft.aufirst=S&rft.date=1987-02-01&rft.volume=19&rft.issue=1+Pt+2&rft.spage=1262&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-20 N1 - Date created - 1990-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Action-Naming Performance in Four Syndromes of Aphasia AN - 85492171; 8802168 AB - Action-naming was studied in four types of aphasic patients: Broca's, Wernicke's, anomic, & conduction (N = 11 each group). In influence of situational context on the retrieval of action Vs, & the ability of error types to discriminate between aphasia types were examined. Eighteen action Vs which required little or no context for their depiction were selected as stimuli; 9 were high- & 9 low-frequency. Black & white line drawings were used in a confrontation naming & a picture description task. Results were compared with those obtained in a variety of earlier studies involving naming of objects. Overall performance on actions was poorer for all groups than shown for object naming in previous studies. This may be related to semantic complexity & abstraction. Correlations between scores on the two tasks were highest for Wernicke's aphasics, followed by conduction, Broca's, & anomic aphasics. 4 Tables, 2 Figures, 20 References. B. Annesser Murray JF - Brain and Language AU - Williams, Sarah E AU - Canter, Gerald J AD - Audiology & Speech Pathology 126 Veterans Administration Medical Center, Bay Pines FL 33504 Y1 - 1987///0, PY - 1987 DA - 0, 1987 SP - 124 EP - 136 VL - 32 IS - 1 SN - 0093-934X, 0093-934X KW - action-naming KW - Broca's/Wernicke's/anomic/conduction aphasics compared KW - confrontation naming/picture description tasks KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85492171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Action-Naming+Performance+in+Four+Syndromes+of+Aphasia&rft.au=Williams%2C+Sarah+E%3BCanter%2C+Gerald+J&rft.aulast=Williams&rft.aufirst=Sarah&rft.date=1987-01-01&rft.volume=32&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Pathology (la4); Nervous System Pathology (ne3) ER - TY - JOUR T1 - Reapportioning Time for Aphasia Rehabilitation: A Point of View AN - 85329637; llba-8706023 AB - Some issues relating to the value of aphasia therapy are addressed, including whether therapy enhances recovery beyond what would be expected from spontaneous recovery & whether the type of treatment makes a difference. Information about aphasics with syndromes of varying degrees of severity is reviewed as a basis for supporting reapportionment of the amount of therapy time devoted to different types of aphasia. It is suggested that more time should be spent with less-impaired patients, & less time with more-impaired patients. In Global Aphasia: The Case for Treatment, Gil Edelman (Hammersmith Hospital, London, England) agrees that patients with global aphasia have a poorer diagnosis for recovery than those with less severe syndromes, but argues for a more optimistic approach to therapy. It is argued that Marshall has overlooked some literature on the effectiveness of innovative therapeutic techniques. In Is There Support for Assumptions Underlying 'Reapportioning Time for Aphasia Rehabilitation: A Point of View'?, Carl L. Parsons (School Communication Disorders, Lincoln Instit of Health Services, Melbourne, Australia) outlines some issues raised by Marshall, such as his implication that clinicians have "ignored" experimental evidence concerning therapeutic results with global aphasics. In Comments on 'Reapportioning Time for Aphasia Rehabilitation: A Point of View' - A Suggestion in Search of Support, Robert T. Wertz (Veterans Administration Medical Center, Martinez, CA) supports the importance of the issues raised by Marshall but suggests that no conclusions be drawn until more data are available. It is argued that existing evidence does not support the claim that more treatment should be devoted to mildly aphasic patients. In Reapportioning Time for Aphasia Rehabilitation: A Point of View. Reply to Wertz, Edelman, and Parsons, Marshall addresses the preceding criticisms & notes that viewpoints are just that, & that problems are solved through exploration. 144 References. B. Annesser Murray JF - Aphasiology AU - Marshall, Robert C AD - Veterans Administration Medical Center 126, 3710 SW US Veterans Hospital Rd Portland OR 97207 Y1 - 1987/01// PY - 1987 DA - Jan 1987 SP - 59 EP - 73 VL - 1 IS - 1 SN - 0268-7038, 0268-7038 KW - aphasia therapy value KW - treatment type/time KW - various viewpoints KW - *Language Therapy (la7a) KW - *Language Pathology (la4) KW - *Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85329637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Reapportioning+Time+for+Aphasia+Rehabilitation%3A+A+Point+of+View&rft.au=Marshall%2C+Robert+C&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1987-01-01&rft.volume=1&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - SuppNotes - Comments, 75-90, Reply, 91-95. N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (ap1); *Language Pathology (la4); *Language Therapy (la7a) ER - TY - JOUR T1 - Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis. AN - 81044616; 3659584 AB - A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis. This fatal complication occurred despite a careful selection of the patient and the presence of a lytic state. Embolization of a fragmented thrombus or/and attenuation of the lytic state leading to fresh embolization is/are the possible mechanism(s). Although rare, massive pulmonary embolus must be considered to be a major risk of thrombolytic therapy for deep venous thrombosis. JF - Respiration; international review of thoracic diseases AU - Sassoon, C S AU - Te, T T AU - Light, R W AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, Calif. Y1 - 1987 PY - 1987 DA - 1987 SP - 54 EP - 58 VL - 52 IS - 1 SN - 0025-7931, 0025-7931 KW - Streptokinase KW - EC 3.4.- KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Pulmonary Embolism -- pathology KW - Streptokinase -- adverse effects KW - Pulmonary Embolism -- chemically induced KW - Streptokinase -- therapeutic use KW - Thrombophlebitis -- drug therapy KW - Pulmonary Embolism -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81044616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiration%3B+international+review+of+thoracic+diseases&rft.atitle=Massive+pulmonary+embolism+complicating+streptokinase+treatment+for+deep+vein+thrombosis.&rft.au=Sassoon%2C+C+S%3BTe%2C+T+T%3BLight%2C+R+W&rft.aulast=Sassoon&rft.aufirst=C&rft.date=1987-01-01&rft.volume=52&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Respiration%3B+international+review+of+thoracic+diseases&rft.issn=00257931&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-04 N1 - Date created - 1987-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hemodynamic and pharmacokinetic aspects of the interactions between verapamil and pindolol. AN - 81040020; 3659118 AB - Combined administration of verapamil, a phenylalkylamine calcium-entry antagonist, with a pure beta-adrenoceptor blocker, propranolol, produces profound cardiovascular depression associated with decreased hepatic clearance of both drugs. We have therefore studied the combination of verapamil and pindolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic activity (ISA), to evaluate whether or not the property of ISA will confer protection from the usual toxic effects observed with verapamil and a beta-adrenoceptor blocking agent. In an anesthetized dog model, dosing regimens which produced stable plasma concentrations of either verapamil and/or pindolol resulted in drug effects which were closely related to the plasma levels of the individual agents. When pindolol was combined with verapamil, profound depression of cardiac pump function occurred, similar to that previously found with propranolol. Further, plasma concentrations of verapamil promptly increased into a toxic range during combined administration with pindolol. In summary, since the cardiovascular depression resulting from verapamil and pindolol in combination is similar to that which occurs with verapamil and propranolol, ISA does not appear to obviate the toxic effects of verapamil and a beta-adrenoceptor agent in combination. JF - Pharmacology AU - Hamann, S R AU - Kaltenborn, K E AU - McAllister, R G AD - Research Service, Veterans Administration Medical Center, Lexington, Ky. Y1 - 1987 PY - 1987 DA - 1987 SP - 326 EP - 336 VL - 34 IS - 6 SN - 0031-7012, 0031-7012 KW - Pindolol KW - BJ4HF6IU1D KW - Verapamil KW - CJ0O37KU29 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Dogs KW - Male KW - Hemodynamics -- drug effects KW - Pindolol -- pharmacokinetics KW - Verapamil -- pharmacokinetics KW - Pindolol -- pharmacology KW - Verapamil -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81040020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology&rft.atitle=Hemodynamic+and+pharmacokinetic+aspects+of+the+interactions+between+verapamil+and+pindolol.&rft.au=Hamann%2C+S+R%3BKaltenborn%2C+K+E%3BMcAllister%2C+R+G&rft.aulast=Hamann&rft.aufirst=S&rft.date=1987-01-01&rft.volume=34&rft.issue=6&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Pharmacology&rft.issn=00317012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-29 N1 - Date created - 1987-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The effect of a structured education program on knowledge and psychomotor skills of patients using beclomethasone dipropionate aerosol for steroid dependent asthma. AN - 81024424; 3654237 AB - The purpose of the study was to evaluate the efficacy of a structured education program on knowledge and psychomotor skills of subjects using inhaled beclomethasone dipropionate. The sample was comprised of 26 male outpatients with a mean age of sixty years (range 49-69 yrs) and mean educational level of 11 years (range 7-18 yrs). Subjects were tested to assess knowledge of drug action, self-administration, and side effects. Skill in self-administration was assessed by two independent raters who were blind to group assignment. Then, patients were randomly assigned to an experimental group (n = 13), who received a structured educational program, or a control group (n = 13), who received no structured educational interventions. Patients were retested four weeks after randomization. Subjects in the experimental and control groups did not differ significantly with respect to their initial mean knowledge and performance scores. The post-test mean knowledge score was significantly higher when compared to initial score for each group. Mean knowledge score at post-test did not differ significantly between groups. However, when comparing post-test performance scores to initial scores the experimental group had a significantly greater increase in mean score than the control group. It is concluded that a structured patient education program is an effective method for improving the psychomotor skills necessary for proper use of beclomethasone dipropionate aerosol. JF - Health education quarterly AU - Heringa, P AU - Lawson, L AU - Reda, D AD - Nursing Service for Ambulatory Care, Veterans Administration, Edward Hines Jr. Hospital, IL 60141. Y1 - 1987 PY - 1987 DA - 1987 SP - 309 EP - 317 VL - 14 IS - 3 SN - 0195-8402, 0195-8402 KW - Aerosols KW - 0 KW - Beclomethasone KW - KGZ1SLC28Z KW - Index Medicus KW - Evaluation Studies as Topic KW - Self Administration KW - Humans KW - Substance-Related Disorders -- etiology KW - Educational Measurement -- methods KW - Outcome and Process Assessment (Health Care) KW - Aged KW - Middle Aged KW - Male KW - Patient Education as Topic KW - Asthma -- drug therapy KW - Beclomethasone -- administration & dosage KW - Psychomotor Performance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81024424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+education+quarterly&rft.atitle=The+effect+of+a+structured+education+program+on+knowledge+and+psychomotor+skills+of+patients+using+beclomethasone+dipropionate+aerosol+for+steroid+dependent+asthma.&rft.au=Heringa%2C+P%3BLawson%2C+L%3BReda%2C+D&rft.aulast=Heringa&rft.aufirst=P&rft.date=1987-01-01&rft.volume=14&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Health+education+quarterly&rft.issn=01958402&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-30 N1 - Date created - 1987-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary toxicity associated with fludarabine monophosphate. AN - 81023923; 2443463 AB - Fludarabine monophosphate (FAMP), the 2-fluoro, 5' phosphate derivative of 9-beta-D-arabinofuranosyl adenine (ara-A), is a purine nucleoside antimetabolite presently undergoing clinical testing for the treatment of a variety of malignancies including lymphoproliferative disorders and acute leukemia. We report a case of diffuse interstitial pneumonitis during treatment of chronic lymphocytic leukemia with FAMP. This resolved quickly with high dose steroids, recurred with steroid withdrawal, and abated with further steroid therapy. To our knowledge, this is the first reported case of fludarabine monophosphate associated pulmonary toxicity. JF - Investigational new drugs AU - Hurst, P G AU - Habib, M P AU - Garewal, H AU - Bluestein, M AU - Paquin, M AU - Greenberg, B R AD - Medical Service, Veterans Administration Medical Center, Tucson, Arizona. Y1 - 1987 PY - 1987 DA - 1987 SP - 207 EP - 210 VL - 5 IS - 2 SN - 0167-6997, 0167-6997 KW - Antimetabolites, Antineoplastic KW - 0 KW - Arabinonucleotides KW - Vidarabine Phosphate KW - 106XV160TZ KW - fludarabine phosphate KW - 1X9VK9O1SC KW - Index Medicus KW - Leukemia, Lymphoid -- drug therapy KW - Humans KW - Middle Aged KW - Lung -- pathology KW - Male KW - Arabinonucleotides -- adverse effects KW - Vidarabine Phosphate -- therapeutic use KW - Vidarabine Phosphate -- adverse effects KW - Pulmonary Fibrosis -- pathology KW - Antimetabolites, Antineoplastic -- adverse effects KW - Pulmonary Fibrosis -- chemically induced KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Vidarabine Phosphate -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81023923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=Pulmonary+toxicity+associated+with+fludarabine+monophosphate.&rft.au=Hurst%2C+P+G%3BHabib%2C+M+P%3BGarewal%2C+H%3BBluestein%2C+M%3BPaquin%2C+M%3BGreenberg%2C+B+R&rft.aulast=Hurst&rft.aufirst=P&rft.date=1987-01-01&rft.volume=5&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship between ethanol, HDL, and vascular prostacyclin production. AN - 78056395; 3137709 JF - Transactions of the Association of American Physicians AU - Baraona, E AU - Guivernau, M AU - Lieber, C S AD - Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, New York. Y1 - 1987 PY - 1987 DA - 1987 SP - 70 EP - 79 VL - 100 SN - 0066-9458, 0066-9458 KW - Acetates KW - 0 KW - Arachidonic Acids KW - Lipoproteins, HDL KW - Prostaglandin Endoperoxides KW - Prostaglandins H KW - Arachidonic Acid KW - 27YG812J1I KW - Ethanol KW - 3K9958V90M KW - 6-Ketoprostaglandin F1 alpha KW - 58962-34-8 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Animals KW - Acetaldehyde -- pharmacology KW - Alcoholism -- metabolism KW - 6-Ketoprostaglandin F1 alpha -- biosynthesis KW - Arachidonic Acids -- metabolism KW - Alcohol Drinking KW - Acetates -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Kinetics KW - In Vitro Techniques KW - Male KW - Aorta -- metabolism KW - Prostaglandin Endoperoxides -- biosynthesis KW - Aorta -- drug effects KW - Ethanol -- pharmacology KW - Lipoproteins, HDL -- blood KW - Muscle, Smooth, Vascular -- drug effects KW - Prostaglandins H -- biosynthesis KW - Muscle, Smooth, Vascular -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78056395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+Association+of+American+Physicians&rft.atitle=Relationship+between+ethanol%2C+HDL%2C+and+vascular+prostacyclin+production.&rft.au=Baraona%2C+E%3BGuivernau%2C+M%3BLieber%2C+C+S&rft.aulast=Baraona&rft.aufirst=E&rft.date=1987-01-01&rft.volume=100&rft.issue=&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+Association+of+American+Physicians&rft.issn=00669458&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-13 N1 - Date created - 1988-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of the nucleus basalis of Meynert in dementia: review and reconsideration. AN - 78037003; 3331115 AB - The nucleus basalis of Meynert (nbM), a cholinergic nuclear group located in the sublenticular region, receives afferent input principally from the limbic system and projects to most of the cerebral cortex. The nucleus is atrophic in dementia of the Alzheimer type (DAT) and several other dementing disorders and attempts have been made to relate cholinergic deficits as well as intellectual impairment to nbM alterations. A cortical cholinergic deficit is routinely associated with atrophy of nbM, but there is no consistent relationship between changes in nbM and histopathologic alterations of the Alzheimer type and a variable association between nbM changes and dementia. The available information suggests that atrophy of nbM and cortical cholinergic deficits have a contributory role in several dementia syndromes but cannot account for many pathologic and behavioral aspects of these disorders. JF - Alzheimer disease and associated disorders AU - Cummings, J L AU - Benson, D F AD - Neurobehavior Unit, West Los Angeles Veterans Administration Medical Center (Brentwood Division), Los Angeles, California 90073. Y1 - 1987 PY - 1987 DA - 1987 SP - 128 EP - 155 VL - 1 IS - 3 SN - 0893-0341, 0893-0341 KW - Gangliosides KW - 0 KW - Nerve Growth Factors KW - Choline O-Acetyltransferase KW - EC 2.3.1.6 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Acetylcholine -- physiology KW - Animals KW - Alcoholism -- pathology KW - Nerve Growth Factors -- pharmacology KW - Humans KW - Schizophrenia -- pathology KW - Choline O-Acetyltransferase -- metabolism KW - Nervous System Diseases -- pathology KW - Parkinson Disease -- pathology KW - Gangliosides -- pharmacology KW - Aging -- pathology KW - Atrophy KW - Nerve Tissue -- transplantation KW - Alzheimer Disease -- pathology KW - Dementia -- pathology KW - Substantia Innominata -- pathology KW - Substantia Innominata -- physiology KW - Basal Ganglia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78037003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer+disease+and+associated+disorders&rft.atitle=The+role+of+the+nucleus+basalis+of+Meynert+in+dementia%3A+review+and+reconsideration.&rft.au=Cummings%2C+J+L%3BBenson%2C+D+F&rft.aulast=Cummings&rft.aufirst=J&rft.date=1987-01-01&rft.volume=1&rft.issue=3&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Alzheimer+disease+and+associated+disorders&rft.issn=08930341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The properties of human C5a anaphylatoxin. The significance of C5a formation during hemodialysis. AN - 77973537; 3327650 AB - Human C5a anaphylatoxin is a potent bioactive molecule that possesses both spasmogenic and leukocyte-related properties. As such, it normally serves as a local mediator of the acute inflammatory response. Additionally, C5a, through its actions of mononuclear phagocytes, may act to bridge the gap in the acute-chronic inflammatory continuum. While these properties are critical to normal host defense mechanisms, it is now apparent that this anaphylatoxin and/or its des-Arg74 derivative, may exert significant systemic effects that are manifest as cardiopulmonary abnormalities and intravascular activation of granulocytes. Knowledge of these properties is critically important for understanding the clinical sequelae exhibited by patients undergoing extracorporeal circulation since we now know that both hemodialysis and cardiopulmonary bypass [28-30] procedures promote intravascular complement activation and C5a formation. Viewed in this context, it seems reasonable to postulate that many of the immediate and delayed responses to extracorporeal circulation might be mediated by C5a formed in the extracorporeal circuit (table IV). For example, it is now recognized that a few particularly susceptible patients display adverse reactions during the initial phases of hemodialysis. The symptoms of this so-called 'first-use syndrome' may range from severe urticaria and angioedema to life-threatening bronchospasm, hypotension, and cardiopulmonary collapse. Some investigators have presented data which suggest that complement-derived products may be causative of these symptoms in some patients [31]. While this hypothesis remains to be confirmed, present evidence clearly demonstrates that C5a alone may produce many of the observed phenomena. In addition to the acute effects produced by C5a, both our own basic studies and the clinical investigations presented by others at this conference suggest that the long-term effects of repeated C5a exposure in the dialyzed patient may be considerable. Thus, there has been a great deal of interest in the role of complement-derived mediators as initiators of leukocyte degranulation and toxic oxygen radical production and an exploration of the significance of these events in the eventual development of chronic pulmonary fibrosis in the dialyzed patient. Similarly, the effects of repeated exposure to IL-1 that has been postulated to occur as a result of C5a triggering of monocytes during dialysis is currently an active area of investigation.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Contributions to nephrology AU - Chenoweth, D E AD - Veterans Administration Medical Center, San Diego, Calif. Y1 - 1987 PY - 1987 DA - 1987 SP - 51 EP - 71 VL - 59 SN - 0302-5144, 0302-5144 KW - Anaphylatoxins KW - 0 KW - Complement C3 KW - Complement C5 KW - Peptides KW - Receptor, Anaphylatoxin C5a KW - Receptors, Complement KW - Complement C3a KW - 80295-42-7 KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Granulocytes -- metabolism KW - Humans KW - Complement C3 -- biosynthesis KW - Receptors, Complement -- metabolism KW - Complement C5 -- metabolism KW - Complement C5 -- pharmacokinetics KW - Inflammation -- etiology KW - Anaphylatoxins -- physiology KW - Anaphylatoxins -- metabolism KW - Renal Dialysis KW - Complement C5 -- physiology KW - Peptides -- physiology KW - Anaphylatoxins -- biosynthesis KW - Complement C5 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77973537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=The+properties+of+human+C5a+anaphylatoxin.+The+significance+of+C5a+formation+during+hemodialysis.&rft.au=Chenoweth%2C+D+E&rft.aulast=Chenoweth&rft.aufirst=D&rft.date=1987-01-01&rft.volume=59&rft.issue=&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-11 N1 - Date created - 1988-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Extinction of conditioned responses in abstinent cocaine or opioid users. AN - 77961223; 3125446 JF - NIDA research monograph AU - Childress, A R AU - McLellan, A T AU - Ehrman, R N AU - O'Brien, C P AD - Veterans Administration Medical Center, Philadelphia, Pa. Y1 - 1987 PY - 1987 DA - 1987 SP - 189 EP - 195 VL - 76 SN - 1046-9516, 1046-9516 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Substance Withdrawal Syndrome -- etiology KW - Random Allocation KW - Humans KW - Adult KW - Substance Withdrawal Syndrome -- therapy KW - Male KW - Extinction, Psychological KW - Conditioning (Psychology) KW - Opioid-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77961223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Extinction+of+conditioned+responses+in+abstinent+cocaine+or+opioid+users.&rft.au=Childress%2C+A+R%3BMcLellan%2C+A+T%3BEhrman%2C+R+N%3BO%27Brien%2C+C+P&rft.aulast=Childress&rft.aufirst=A&rft.date=1987-01-01&rft.volume=76&rft.issue=&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-29 N1 - Date created - 1988-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Primary hypogonadism associated with o,p' DDD (mitotane) therapy. AN - 77960646; 3441014 AB - Mitotane is a drug which is concentrated largely in adipose tissue and the adrenal glands. It has a remarkable specificity for the adrenal cortex and can produce necrosis of that organ; consequently, it has been used as a therapeutic agent for adrenocortical carcinoma. Because of the similarity between adrenocortical and testicular tissue, mitotane could be expected to cause testicular damage; however, there is sparse support for this in the literature. We recently studied a patient who developed impotency due to primary testicular failure at the time that he was treated with mitotane. A testicular biopsy, performed about four months after the drug was discontinued, showed normal appearing Leydig cells and atrophy of the seminiferous tubules with the picture of a maturation arrest. In the four and one half years since he last received mitotane, the patient's libido has slowly improved and his plasma testosterone, gonadotropins and LH response to gonadotropin-releasing hormone have become essentially normal. We propose that mitotane can be cytotoxic to the testis as it is to the adrenal cortex. JF - Journal of toxicology. Clinical toxicology AU - Sparagana, M AD - Medical and Research Services, Veterans Administration Hospital, Hines, Illinois 60141. Y1 - 1987 PY - 1987 DA - 1987 SP - 463 EP - 472 VL - 25 IS - 6 SN - 0731-3810, 0731-3810 KW - Gonadotropins KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Mitotane KW - 78E4J5IB5J KW - Luteinizing Hormone KW - 9002-67-9 KW - Abridged Index Medicus KW - Index Medicus KW - Gonadotropins -- blood KW - Erectile Dysfunction -- chemically induced KW - Testis -- drug effects KW - Humans KW - Testosterone -- blood KW - Adult KW - Luteinizing Hormone -- blood KW - ACTH Syndrome, Ectopic -- drug therapy KW - Male KW - Mitotane -- adverse effects KW - Hypogonadism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77960646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology.+Clinical+toxicology&rft.atitle=Primary+hypogonadism+associated+with+o%2Cp%27+DDD+%28mitotane%29+therapy.&rft.au=Sparagana%2C+M&rft.aulast=Sparagana&rft.aufirst=M&rft.date=1987-01-01&rft.volume=25&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology.+Clinical+toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the effects of cocaine and d-amphetamine on the pharmacological actions of methadone. AN - 77954818; 3125463 JF - NIDA research monograph AU - Liu, S J AU - Wang, R I AD - Pharmacology Research Laboratories, Veterans Administration Medical Center, Milwaukee, WI 53295. Y1 - 1987 PY - 1987 DA - 1987 SP - 302 EP - 308 VL - 76 SN - 1046-9516, 1046-9516 KW - Naloxone KW - 36B82AMQ7N KW - Cocaine KW - I5Y540LHVR KW - Dextroamphetamine KW - TZ47U051FI KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Naloxone -- pharmacology KW - Animals KW - Drug Interactions KW - Analgesia KW - Substance Withdrawal Syndrome -- etiology KW - Body Temperature -- drug effects KW - Mice KW - Male KW - Cocaine -- toxicity KW - Cocaine -- pharmacology KW - Methadone -- pharmacology KW - Dextroamphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77954818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Comparison+of+the+effects+of+cocaine+and+d-amphetamine+on+the+pharmacological+actions+of+methadone.&rft.au=Liu%2C+S+J%3BWang%2C+R+I&rft.aulast=Liu&rft.aufirst=S&rft.date=1987-01-01&rft.volume=76&rft.issue=&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-29 N1 - Date created - 1988-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mood states can elicit conditioned withdrawal and craving in opiate abuse patients. AN - 77954625; 3125443 JF - NIDA research monograph AU - Childress, A R AU - McLellan, A T AU - Natale, M AU - O'Brien, C P AD - Philadelphia Veterans Administration Medical Center. Y1 - 1987 PY - 1987 DA - 1987 SP - 137 EP - 144 VL - 76 SN - 1046-9516, 1046-9516 KW - Narcotics KW - 0 KW - Index Medicus KW - Depression KW - Anxiety KW - Humans KW - Adult KW - Euphoria KW - Male KW - Anger KW - Substance Withdrawal Syndrome -- psychology KW - Affect KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77954625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Mood+states+can+elicit+conditioned+withdrawal+and+craving+in+opiate+abuse+patients.&rft.au=Childress%2C+A+R%3BMcLellan%2C+A+T%3BNatale%2C+M%3BO%27Brien%2C+C+P&rft.aulast=Childress&rft.aufirst=A&rft.date=1987-01-01&rft.volume=76&rft.issue=&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-29 N1 - Date created - 1988-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modification of the renal hemodynamic response to vasoconstrictors by calcium antagonists. AN - 77953834; 3442293 AB - Theoretical considerations suggest that the renal response to calcium antagonists may vary depending on the factors influencing basal vascular tone. Studies were conducted using the isolated perfused rat kidney to determine the response to calcium antagonists under conditions in which the determinants of renal vascular tone were accurately defined. With this model, calcium antagonists elicit vasodilation only in the presence of a vasoconstrictor. In this setting, however, the degree of vasodilation elicited depends on the nature of the vasoconstrictor employed. Thus, the reduction in renal perfusate flow (RPF) elicited by KCl-induced depolarization was completely reversed by the calcium antagonist, nitrendipine. In contrast, identical levels of vasoconstriction elicited by norepinephrine or angiotensin II were only partially reversed, suggesting that these agonists activate the renal vasculature by mechanisms that are more complex than membrane depolarization. Examination of the response of glomerular filtration rate (GFR) revealed that in the presence of norepinephrine and angiotensin II, nitrendipine exerted a preferential augmentation of GFR. Thus, concentrations that produced only modest effects on RPF increased GFR to levels equal to or exceeding control values. This selective augmentation of GFR did not occur during the renal vasoconstriction elicited by KCl. It is proposed that renal microvessels exhibit regional heterogeneity in regard to activation mechanisms and sensitivity to calcium antagonists. Calcium antagonists may selectively attenuate agonist-induced vasoconstriction of preglomerular vessels. JF - American journal of nephrology AU - Loutzenhiser, R AU - Epstein, M AD - Nephrology Section, Veterans Administration Medical Center, Miami, Fla. Y1 - 1987 PY - 1987 DA - 1987 SP - 7 EP - 16 VL - 7 Suppl 1 SN - 0250-8095, 0250-8095 KW - Calcium Channel Blockers KW - 0 KW - Vasoconstrictor Agents KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Hemodynamics -- drug effects KW - Animals KW - Drug Interactions KW - Pulsatile Flow -- drug effects KW - Perfusion KW - Glomerular Filtration Rate -- drug effects KW - In Vitro Techniques KW - Kidney -- physiology KW - Kidney -- drug effects KW - Vasoconstriction -- drug effects KW - Male KW - Vasoconstrictor Agents -- pharmacology KW - Renal Circulation -- drug effects KW - Calcium Channel Blockers -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77953834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+nephrology&rft.atitle=Modification+of+the+renal+hemodynamic+response+to+vasoconstrictors+by+calcium+antagonists.&rft.au=Loutzenhiser%2C+R%3BEpstein%2C+M&rft.aulast=Loutzenhiser&rft.aufirst=R&rft.date=1987-01-01&rft.volume=7+Suppl+1&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=American+journal+of+nephrology&rft.issn=02508095&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Discrimination between the nuclear lamin and intermediate filament (cytokeratin/vimentin) proteins of rat hepatic tumor cells by differential solubility and electrophoretic criteria. AN - 77950730; 2449371 AB - 1. The major proteins which comprise the high salt/detergent-insoluble cytoskeletal matrix of rat hepatic tumor cells containing abnormal (Mallory body-like) aggregates of intermediate filaments were distinguished on the basis of electrophoretic mobility and differential solubility. 2. Gel electrophoresis of the intermediate filament-enriched cytoskeletal fraction of Mallory body hepatic tumor cells revealed the presence of: (a) intermediate filament proteins typical of cultured liver epithelial cells (cytokeratins A and D, vimentin), (b) some residual actin and, (c) two peptides of Mr = 68,000-72,000. 3. Analysis of the products of filament disassembly/reassembly mixtures indicated that the two Mr = 68,000-72,000 peptide species had the solubility characteristics of nuclear lamins. 4. The presence of nuclear lamin proteins in the high salt/detergent-resistant fraction of cultured liver cells was consistent with the resolution of residual nuclear-like structures in extracted cell monolayers. 5. Thus, while cytokeratin/vimentin-class intermediate filament proteins and nuclear lamins co-isolate from rat liver cells under conditions of high salt/detergent extraction, these two types of cytoskeletal proteins could be distinguished on the basis of their differential solubility and molecular weight. JF - The International journal of biochemistry AU - Ryan, M P AU - Higgins, P J AD - Laboratory of Cell and Molecular Biology, Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1987 PY - 1987 DA - 1987 SP - 1187 EP - 1192 VL - 19 IS - 12 SN - 0020-711X, 0020-711X KW - Intermediate Filament Proteins KW - 0 KW - Lamins KW - Nuclear Proteins KW - Vimentin KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Rats KW - Animals KW - Solubility KW - Electrophoresis, Polyacrylamide Gel KW - Cell Line KW - Nuclear Proteins -- isolation & purification KW - Intermediate Filament Proteins -- isolation & purification KW - Vimentin -- isolation & purification KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- analysis KW - Liver Neoplasms -- chemically induced KW - Keratins -- isolation & purification KW - Cell Nucleus -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77950730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+biochemistry&rft.atitle=Discrimination+between+the+nuclear+lamin+and+intermediate+filament+%28cytokeratin%2Fvimentin%29+proteins+of+rat+hepatic+tumor+cells+by+differential+solubility+and+electrophoretic+criteria.&rft.au=Ryan%2C+M+P%3BHiggins%2C+P+J&rft.aulast=Ryan&rft.aufirst=M&rft.date=1987-01-01&rft.volume=19&rft.issue=12&rft.spage=1187&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+biochemistry&rft.issn=0020711X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol and dilated cardiomyopathy: incidence and correlation with clinical outcome. AN - 77949781; 3437485 AB - Among a group of 28 elderly veterans with dilated cardiomyopathy regularly attending an outpatient heart failure clinic, half had a history of habitual heavy drinking. It was concluded that chronic heavy drinking was the only identifiable factor responsible for the heart failure in three of these patients. Eleven other patients also had chronic heavy drinking as a possible etiological factor of their heart failure in addition to Coronary Artery Disease and/or hypertension. Less than 50% of the heavy drinkers totally abstained from alcohol after seeking medical treatment although they reduced their drinking significantly. All three patients with clear alcoholic cardiomyopathy discontinued drinking and showed marked improvement in cardiac status. The discontinuation of drinking did not appear to be associated with improvement in the remaining heavy drinkers and those patients who reported a history of moderate drinking. JF - Journal of substance abuse treatment AU - Wang, R AU - Mallon, J AU - Alterman, A I AU - McLellan, A T AD - Veterans Administration Medical Center, Philadelphia, Pennsylvania. Y1 - 1987 PY - 1987 DA - 1987 SP - 209 EP - 213 VL - 4 IS - 3-4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Socioeconomic Factors KW - Humans KW - Aged KW - Middle Aged KW - Alcohol Drinking KW - Male KW - Cardiomyopathy, Dilated -- therapy KW - Cardiomyopathy, Dilated -- etiology KW - Cardiomyopathy, Alcoholic -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77949781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Alcohol+and+dilated+cardiomyopathy%3A+incidence+and+correlation+with+clinical+outcome.&rft.au=Wang%2C+R%3BMallon%2C+J%3BAlterman%2C+A+I%3BMcLellan%2C+A+T&rft.aulast=Wang&rft.aufirst=R&rft.date=1987-01-01&rft.volume=4&rft.issue=3-4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term effects of monaural, binaural and no amplification in subjects with bilateral hearing loss. AN - 77949054; 3438702 AB - This study expands upon our earlier work by comparing initial PB scores and audiometric thresholds with results obtained 4-17 years later for subjects with bilateral sensorineural hearing losses who were monaurally aided (n = 48), binaurally aided (n = 19), or unaided (n = 19). Thresholds decreased slightly for all groups, but aided and unaided ears did not differ significantly in this respect, revealing no acoustic trauma effect due to hearing aid use. PB scores decreased significantly only for the unaided ear of the monaurally aided subjects, but not for their aided ear, or for the binaurally aided or unaided groups. These findings suggest an auditory deprivation effect for the unaided ear of those wearing a monaural hearing aid. Changes in PB scores were not correlated with duration between the two test dates. Changes in PB scores were correlated with degree of hearing loss only for the unaided group. JF - Scandinavian audiology AU - Gelfand, S A AU - Silman, S AU - Ross, L AD - Veterans Administration Medical Center, East Orange, New Jersey. Y1 - 1987 PY - 1987 DA - 1987 SP - 201 EP - 207 VL - 16 IS - 4 SN - 0105-0397, 0105-0397 KW - Index Medicus KW - Speech Perception KW - Auditory Threshold KW - Humans KW - Adult KW - Aged KW - Speech Reception Threshold Test KW - Middle Aged KW - Follow-Up Studies KW - Hearing Loss, Noise-Induced -- rehabilitation KW - Male KW - Hearing Loss -- rehabilitation KW - Hearing Loss, Bilateral -- rehabilitation KW - Hearing Loss, Sensorineural -- rehabilitation KW - Hearing Aids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77949054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+audiology&rft.atitle=Long-term+effects+of+monaural%2C+binaural+and+no+amplification+in+subjects+with+bilateral+hearing+loss.&rft.au=Gelfand%2C+S+A%3BSilman%2C+S%3BRoss%2C+L&rft.aulast=Gelfand&rft.aufirst=S&rft.date=1987-01-01&rft.volume=16&rft.issue=4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Scandinavian+audiology&rft.issn=01050397&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heterogeneity of Echis venoms from different sources. AN - 77942676; 3438922 AB - The heterogeneity of separate Echis carinatus and Echis coloratus venom lots were evaluated by high performance size-exclusion chromatography, as well as by clotting and esterolytic activities. Each lot of E. carinatus and E. coloratus venoms appeared to be unique. The variation in E. carinatus venom activities from snakes within the same species could lead to contradictory biochemical and/or physiological test results. JF - Toxicon : official journal of the International Society on Toxinology AU - Schaeffer, R C AD - Microcirculatory Laboratory, Veterans Administration Medical Center, Tucson, AZ. Y1 - 1987 PY - 1987 DA - 1987 SP - 1343 EP - 1346 VL - 25 IS - 12 SN - 0041-0101, 0041-0101 KW - Viper Venoms KW - 0 KW - Index Medicus KW - Animals KW - Chromatography, Gel KW - Hemorrhage -- chemically induced KW - Blood Coagulation -- drug effects KW - Lethal Dose 50 KW - Mice KW - Species Specificity KW - Viper Venoms -- toxicity KW - Viper Venoms -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77942676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Heterogeneity+of+Echis+venoms+from+different+sources.&rft.au=Schaeffer%2C+R+C&rft.aulast=Schaeffer&rft.aufirst=R&rft.date=1987-01-01&rft.volume=25&rft.issue=12&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protection from adriamycin-induced cardiomyopathy in rats. AN - 77937676; 3433883 AB - The use of adriamycin, one of the most potent antineoplastic agents available causes a dose dependent cardiomyopathy. Carnitine does play a central role in myocardial metabolism by controlling fatty acid oxidation and the acetyl-CoA pool. Protective effects of carnitine have been described in different myocardial diseases. We therefore investigated whether chronic carnitine administration could protect from adriamycin-induced cardiomyopathy. As the rat has proved to be an effective model for adriamycin-induced cardiomyopathy, we studied four groups of rats, treated for 6 weeks according to the following protocols: group (I) adriamycin i.v. and carnitine i.p. (II) adriamycin i.v. and NaCl i.p. (III) NaCl i.v. and i.p. (IV) NaCl i.v. and carnitine i.p. After 6 weeks of treatment, hearts were studied in an isolated working rat heart system. Adriamycin/NaCl treated hearts produced reduced cardiac output and left ventricular systolic pressure compared to controls (NaCl/CaCl, group III) or to adriamycin/carnitine treated hearts (Fig. 1-3 and Table 1). The myocardial carnitine content in non-perfused hearts was not influenced by adriamycin therapy, and muscle, kidney and liver carnitine levels were unchanged. However, total plasma carnitine in the adriamycin/NaCl group was significantly elevated, based on increased carnitine esters. Histological changes like degeneration, vacuolization, interstitial edema, fibrosis and mitochondrial damage were pronounced in the adriamycin group but were almost lacking in the carnitine-treated animals.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Zeitschrift fur Kardiologie AU - Shug, A L AD - Metabolic Research Laboratory, William S. Middleton Memorial Veterans Administration Hospital, Madison. Y1 - 1987 PY - 1987 DA - 1987 SP - 46 EP - 52 VL - 76 Suppl 5 SN - 0300-5860, 0300-5860 KW - Doxorubicin KW - 80168379AG KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Perfusion KW - Myocardium -- pathology KW - Myocardium -- ultrastructure KW - Male KW - Cardiomyopathies -- pathology KW - Cardiomyopathies -- prevention & control KW - Cardiomyopathies -- chemically induced KW - Carnitine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77937676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zeitschrift+fur+Kardiologie&rft.atitle=Protection+from+adriamycin-induced+cardiomyopathy+in+rats.&rft.au=Shug%2C+A+L&rft.aulast=Shug&rft.aufirst=A&rft.date=1987-01-01&rft.volume=76+Suppl+5&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Zeitschrift+fur+Kardiologie&rft.issn=03005860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-24 N1 - Date created - 1988-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuridine alone. AN - 77924267; 2963230 AB - The current study was initiated to confirm preliminary reports that 20% or more of patients with colorectal cancer who fail treatment with 5-fluorouracil (FUra) will respond to treatment with either leucovorin plus FUra or with sequential methotrexate, FUra, leucovorin. One hundred two patients with advanced, measureable colorectal cancer who failed treatment with FUra and/or 5-fluorodeoxyuridine (FUdR) were randomized to treatment with either high-dose leucovorin plus FUra (Arm B) or sequential methotrexate, FUra, leucovorin (Arm C). In this interim report, 92 patients were evaluable for toxicity and 89 patients were evaluable for response. Grade 3 or 4 nonhematologic toxicity which was primarily gastrointestinal was experienced by 25% of patients on both treatment arms during at least 1 treatment cycle. Hematologic toxicity was minimal. Among 43 evaluable patients on Arm B, there were 2 complete responses (5%) and 1 minor response (3%). Among 46 evaluable patients on Arm C, there was 1 complete response (2%), 1 partial response (2%), and 6 minor responses (14%). The median time to treatment failure was 2.2 months on Arm B and 3.5 months on Arm C. The median survival was 8.3 months on Arm B and 8.7 months on Arm C. Colorectal cancers that are resistant to FUra are cross-resistant to both experimental combinations. JF - NCI monographs : a publication of the National Cancer Institute AU - Valone, F H AU - Kohler, M AU - Fisher, K AU - Hannigan, J AU - Flam, M AU - Gandara, D AU - Hendrickson, C AU - Richman, E AU - Yu, K P AD - Veterans Administration Medical Center, San Francisco, CA 94121. Y1 - 1987 PY - 1987 DA - 1987 SP - 175 EP - 177 IS - 5 SN - 0893-2751, 0893-2751 KW - Floxuridine KW - 039LU44I5M KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Floxuridine -- administration & dosage KW - Drug Administration Schedule KW - Humans KW - Drug Resistance KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity KW - Fluorouracil -- administration & dosage KW - Rectal Neoplasms -- drug therapy KW - Leucovorin -- administration & dosage KW - Carcinoma -- drug therapy KW - Colonic Neoplasms -- drug therapy KW - Methotrexate -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77924267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=A+Northern+California+Oncology+Group+randomized+trial+of+leucovorin+plus+5-fluorouracil+versus+sequential+methotrexate%2C+5-fluorouracil%2C+and+leucovorin+in+patients+with+advanced+colorectal+cancer+who+failed+treatment+with+5-fluorouracil+or+5-fluorodeoxyuridine+alone.&rft.au=Valone%2C+F+H%3BKohler%2C+M%3BFisher%2C+K%3BHannigan%2C+J%3BFlam%2C+M%3BGandara%2C+D%3BHendrickson%2C+C%3BRichman%2C+E%3BYu%2C+K+P&rft.aulast=Valone&rft.aufirst=F&rft.date=1987-01-01&rft.volume=&rft.issue=5&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific IgA secretion by mononuclear cells within the rat liver. AN - 77908392; 3425422 JF - Advances in experimental medicine and biology AU - Altorfer, J AU - Hardesty, S J AU - Jones, A L AD - Cell Biology and Aging Section, Veterans Administration Medical Center, San Francisco, CA. Y1 - 1987 PY - 1987 DA - 1987 SP - 1139 EP - 1145 VL - 216B SN - 0065-2598, 0065-2598 KW - Immunoglobulin A, Secretory KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Perfusion KW - Cholera Toxin -- immunology KW - In Vitro Techniques KW - Antibody-Producing Cells -- immunology KW - Female KW - Liver -- cytology KW - Liver -- immunology KW - Immunoglobulin A, Secretory -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77908392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Specific+IgA+secretion+by+mononuclear+cells+within+the+rat+liver.&rft.au=Altorfer%2C+J%3BHardesty%2C+S+J%3BJones%2C+A+L&rft.aulast=Altorfer&rft.aufirst=J&rft.date=1987-01-01&rft.volume=216B&rft.issue=&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transport of acetaldehyde in red blood cells. AN - 77908091; 3426680 AB - Alcohol intake caused a much greater elevation of acetaldehyde in red blood cells than in plasma. During ethanol oxidation, most of this metabolite was released from the splanchnic areas and circulated reversibly bound to intracellular components of the erythrocyte. Acetaldehyde was then taken up by extra-splanchnic tissues from both plasma and erythrocytes. Thus, an amount of acetaldehyde much larger than previously thought by measurements in plasma becomes available to exert extra-splanchnic toxicity. The contribution of this route for acetaldehyde transport is markedly enhanced in alcoholics. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Baraona, E AU - DiPadova, C AU - Tabasco, J AU - Lieber, C S AD - Liver Disease and Nutrition Section, Bronx Veterans Administration Medical Center, New York. Y1 - 1987 PY - 1987 DA - 1987 SP - 203 EP - 206 VL - 1 SN - 1358-6173, 1358-6173 KW - Ethanol KW - 3K9958V90M KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Papio KW - Animals KW - Ethanol -- pharmacology KW - Humans KW - Biological Transport KW - Alcoholism -- blood KW - Acetaldehyde -- blood KW - Acetaldehyde -- pharmacokinetics KW - Erythrocytes -- metabolism KW - Erythrocytes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77908091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=Transport+of+acetaldehyde+in+red+blood+cells.&rft.au=Baraona%2C+E%3BDiPadova%2C+C%3BTabasco%2C+J%3BLieber%2C+C+S&rft.aulast=Baraona&rft.aufirst=E&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol problems of the elderly. AN - 77890877; 3322312 JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Atkinson, R M AD - Veterans Administration Medical Center, Portland, OR 97201. Y1 - 1987 PY - 1987 DA - 1987 SP - 415 EP - 417 VL - 22 IS - 4 SN - 0735-0414, 0735-0414 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Aging -- physiology KW - Ethanol -- pharmacology KW - Risk Factors KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Aged KW - Middle Aged KW - Male KW - Alcoholism -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77890877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Alcohol+problems+of+the+elderly.&rft.au=Atkinson%2C+R+M&rft.aulast=Atkinson&rft.aufirst=R&rft.date=1987-01-01&rft.volume=22&rft.issue=4&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol as a teratogen: a decade of research in review. AN - 77890064; 3322304 AB - The teratogenicity of ethanol has been well-documented during the past decade in clinical cases as well as animal models. It has become clear that, short of spontaneous abortion, Fetal Alcohol Syndrome represents the most serious consequence of sustained heavy drinking throughout pregnancy. The overall incidence of FAS is about 1-2/1000 live births, although it is considerably higher if one only considers alcoholic women who continue to drink during pregnancy. The incidence of Fetal Alcohol Effects (FAE) is much higher. Most clinical follow-up studies have failed to find significant improvement of intellectual functioning over time. Moreover, problems with attention, cognition, and perception have become apparent in children exposed to alcohol prenatally but without a clinical diagnosis of FAS. Animal models have demonstrated rather conclusively that ethanol is teratogenic in several species. The effect is dose-dependent and the type of malformation observed depends upon the stage of development when the exposure occurred. A single exposure in a high enough dose is sufficient to produce birth defects and decreased fetal weight in mice. Studies with rats have demonstrated behavioral defects similar to those seen clinically, including hyperactivity and deficiencies in response inhibition. Neuroanatomical reports confirm a structural defect in the hippocampus, as suggested by the behavioral deficits observed. Neurochemical correlates of impaired behavior have been inconsistent. With regard to mechanism of action, impaired placental transfer of essential nutrients has been confirmed by several laboratories, while the role of hypoxia, acetaldehyde, and prostaglandins remains to be proven conclusively. Any, or all, of these potential mechanisms may play a role in alcohol-induced teratogenesis.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Randall, C L AD - Veterans Administration Medical Center, Charleston, South Carolina. Y1 - 1987 PY - 1987 DA - 1987 SP - 125 EP - 132 VL - 1 SN - 1358-6173, 1358-6173 KW - Teratogens KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Female KW - Pregnancy KW - Ethanol -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77890064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=Alcohol+as+a+teratogen%3A+a+decade+of+research+in+review.&rft.au=Randall%2C+C+L&rft.aulast=Randall&rft.aufirst=C&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retinoid effects on the epidermis. AN - 77885598; 3319727 AB - Since metaplasia and gap junction stimulation are prominent features of retinoid activity in embryonic and neoplastic epidermis, it is ironic that the mechanism(s) of retinoid action in postnatal tissues, where these drugs are employed clinically, appears to be different. Histologic studies in both animals and man with both topical and systemic retinoids demonstrate acanthosis, hypergranulosis, and changes in the thickness and organization of the stratum corneum, due to a boost in cell turnover. On an ultrastructural level, desmosomes are actively shed at the level of the spinous layer, leading to many new attachment points along the cell membranes of the outer epidermis. This change coupled with decreased tonofilaments, enhanced keratinocyte autolysis, and intercellular deposition of glycoconjugates (not mucin by standard histochemistry and lectin binding) lead to loosening and fragility of the stratum corneum. The biochemical basis of retinoid activity (in addition to increased cell turnover) appears to be global enhancement of glycoconjugate synthesis and the generation of less mature keratins. These epidermal effects of retinoids can be exploited therapeutically: (1) to cause loosening of thickened stratum corneum, e.g., in psoriasis or ichthyosis; (2) to enhance penetration of pharmacologic agents, e.g., 5-FU, across hypertrophic actinic keratoses; and finally (3) in neoplastic epidermis, where mucous metaplasia and gap junction proliferation occur, retinoids can normalize differentiation. JF - Dermatologica AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, Calif. Y1 - 1987 PY - 1987 DA - 1987 SP - 28 EP - 36 VL - 175 Suppl 1 SN - 0011-9075, 0011-9075 KW - Glycoconjugates KW - 0 KW - Retinoids KW - Index Medicus KW - Skin Neoplasms -- drug therapy KW - Animals KW - Glycoconjugates -- biosynthesis KW - Epidermis -- drug effects KW - Skin -- metabolism KW - Humans KW - Skin -- pathology KW - Skin -- embryology KW - Metaplasia -- chemically induced KW - Epidermis -- pathology KW - Retinoids -- therapeutic use KW - Skin Diseases -- chemically induced KW - Retinoids -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77885598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatologica&rft.atitle=Retinoid+effects+on+the+epidermis.&rft.au=Elias%2C+P+M&rft.aulast=Elias&rft.aufirst=P&rft.date=1987-01-01&rft.volume=175+Suppl+1&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Dermatologica&rft.issn=00119075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The search for hormonal markers of the risk for alcoholism. AN - 77884778; 3480710 JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Schuckit, M A AU - Gold, E O AU - Risch, S C AD - Department of Psychiatry, Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1987 PY - 1987 DA - 1987 SP - 43 EP - 46 VL - 1 SN - 1358-6173, 1358-6173 KW - Genetic Markers KW - 0 KW - Ethanol KW - 3K9958V90M KW - Prolactin KW - 9002-62-4 KW - Index Medicus KW - Ethanol -- pharmacology KW - Risk Factors KW - Humans KW - Male KW - Prolactin -- blood KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77884778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=The+search+for+hormonal+markers+of+the+risk+for+alcoholism.&rft.au=Schuckit%2C+M+A%3BGold%2C+E+O%3BRisch%2C+S+C&rft.aulast=Schuckit&rft.aufirst=M&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment considerations in anticonvulsant monotherapy. AN - 77879570; 3121290 AB - The long-standing practice of polypharmacy in treating epilepsy is giving way to use of monotherapy. Monotherapy can improve seizure control as well as reduce the risk of serious idiosyncratic reactions, dose-related side effects, and complex drug interactions. Monotherapy also offers improved compliance and cost-effectiveness. The basis of monotherapy is accurate diagnosis and assessment of the patient's seizure type(s), followed by selection of a single appropriate anticonvulsant drug. Many patients currently treated with multiple anticonvulsants can be successfully converted to monotherapy with a carefully monitored program in which troublesome and redundant drugs are gradually withdrawn from the therapeutic regimen. JF - Epilepsia AU - Wilder, B J AD - Neurology Service, Veterans Administration Medical Center, Gainesville, Florida 32602. Y1 - 1987 PY - 1987 DA - 1987 SP - S1 EP - S7 VL - 28 Suppl 2 SN - 0013-9580, 0013-9580 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Patient Compliance KW - Humans KW - Cost-Benefit Analysis KW - Epilepsy -- economics KW - Anticonvulsants -- adverse effects KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77879570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Treatment+considerations+in+anticonvulsant+monotherapy.&rft.au=Wilder%2C+B+J&rft.aulast=Wilder&rft.aufirst=B&rft.date=1987-01-01&rft.volume=28+Suppl+2&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment and long-term follow-up of foot infections in patients with diabetes or ischemia: a randomized, prospective, double-blind comparison of cefoxitin and ceftizoxime. AN - 77845370; 3319172 AB - The efficacy and safety of ceftizoxime and cefoxitin were compared in a randomized, double-blind study of therapy for lower extremity infections in patients with diabetes mellitus or peripheral vascular disease. Overall clinical responses were satisfactory in 82% (23/28) of patients treated with ceftizoxime and in 68% (17/25) of patients treated with cefoxitin. The difference was not statistically significant. Ceftizoxime had superior in vitro activity against Enterobacteriaceae, especially Enterobacter cloacae, whereas cefoxitin had better activity against the Bacteroides fragilis group. Relapses of infection were common in both groups during long-term follow-up; only about one third of patients in either group maintained satisfactory outcomes after one year. More than half of the patients in both groups responded to one or more courses of medical therapy and avoided major amputations for one year following entry into the study. JF - Clinical therapeutics AU - Hughes, C E AU - Johnson, C C AU - Bamberger, D M AU - Reinhardt, J F AU - Peterson, L R AU - Mulligan, M E AU - Gerding, D N AU - George, W L AU - Finegold, S M AD - Infectious Disease Section, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1987 PY - 1987 DA - 1987 SP - 36 EP - 49 VL - 10 Suppl A SN - 0149-2918, 0149-2918 KW - Cefoxitin KW - 6OEV9DX57Y KW - Ceftizoxime KW - C43C467DPE KW - Cefotaxime KW - N2GI8B1GK7 KW - Index Medicus KW - Prospective Studies KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Recurrence KW - Male KW - Female KW - Foot -- blood supply KW - Ischemia -- complications KW - Bacterial Infections -- etiology KW - Foot Diseases -- etiology KW - Cefotaxime -- analogs & derivatives KW - Cefoxitin -- adverse effects KW - Cefotaxime -- therapeutic use KW - Cefotaxime -- adverse effects KW - Foot Diseases -- drug therapy KW - Cefoxitin -- therapeutic use KW - Diabetes Complications KW - Bacterial Infections -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77845370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Treatment+and+long-term+follow-up+of+foot+infections+in+patients+with+diabetes+or+ischemia%3A+a+randomized%2C+prospective%2C+double-blind+comparison+of+cefoxitin+and+ceftizoxime.&rft.au=Hughes%2C+C+E%3BJohnson%2C+C+C%3BBamberger%2C+D+M%3BReinhardt%2C+J+F%3BPeterson%2C+L+R%3BMulligan%2C+M+E%3BGerding%2C+D+N%3BGeorge%2C+W+L%3BFinegold%2C+S+M&rft.aulast=Hughes&rft.aufirst=C&rft.date=1987-01-01&rft.volume=10+Suppl+A&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transmission electron microscopy of urinary sediment in aminoglycoside nephrotoxicity. AN - 77841379; 3685479 AB - Urinary sediment from 20 patients treated with aminoglycosides (AG) was studied using transmission electron microscopy. For the purpose of comparison, urinary sediment was also studied (control) from an additional 9 patients who had acute renal failure (ARF) but who did not receive AG (5 posttransplant, 4 postsurgical). Urinary myeloid bodies and renal tubule cells were analyzed semiquantitatively. The diagnosis of AG nephrotoxicity (or ARF) was made on the basis of a rise in serum creatinine greater than or equal to 0.5 mg/dL from the baseline levels. Among 20 patients, 12 developed AG-ARF, and 11 of these 12 showed myeloid bodies and necrotic renal tubule cells in their urinary sediment. Of the 8 patients that did not develop AG-ARF, 5 showed myeloid bodies and 2 of these also showed renal tubule cells in their urinary sediment. This incidence of necrotic renal tubule cells in the nephrotoxic group is significantly higher than in the nonnephrotoxic group (p less than 0.01). Although no statistical difference was found in the incidence of myeloid bodies between the two groups, the number of myeloid bodies was significantly (p less than 0.05) greater in the nephrotoxic group than in the nonnephrotoxic group. Furthermore, consecutive sediment studies revealed that the appearance of necrotic renal tubule cells (and not of myeloid bodies) coincided with the increase in serum creatinine. All control patients showed necrotic renal tubule cells but no myeloid bodies in their urinary sediment. Thus this study suggests that the presence of necrotic renal tubule cells signifies ARF, and when preceded or accompanied by large numbers of myeloid bodies that it indicates AG-ARF. JF - Renal failure AU - Mandal, A K AU - Mize, G N AU - Birnbaum, D B AD - Department of Medicine, Veterans Administration Medical Center, Augusta, Georgia. Y1 - 1987 PY - 1987 DA - 1987 SP - 63 EP - 81 VL - 10 IS - 2 SN - 0886-022X, 0886-022X KW - Aminoglycosides KW - 0 KW - Anti-Bacterial Agents KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Necrosis KW - Kidney Tubules -- pathology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Microscopy, Electron KW - Creatinine -- blood KW - Male KW - Kidney Tubules -- ultrastructure KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Acute Kidney Injury -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Kidney -- drug effects KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77841379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Renal+failure&rft.atitle=Transmission+electron+microscopy+of+urinary+sediment+in+aminoglycoside+nephrotoxicity.&rft.au=Mandal%2C+A+K%3BMize%2C+G+N%3BBirnbaum%2C+D+B&rft.aulast=Mandal&rft.aufirst=A&rft.date=1987-01-01&rft.volume=10&rft.issue=2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Renal+failure&rft.issn=0886022X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Severity of alcohol dependence and its relationship to additional psychiatric symptoms in male alcoholic inpatients. AN - 77834845; 3687900 AB - Many alcoholics suffer from distress associated with psychiatric symptoms in addition to alcoholism. Although there may be many such symptoms reported by the alcoholic, there may not be enough in any one category to meet DSM III criteria for an additional psychiatric diagnosis, and consequently these symptoms may not be considered in treatment planning. In addition, the prevalence and severity of psychiatric symptoms may be dependent on the progression of alcoholism. The purpose of this study was to examine whether a relationship exists between patterns of psychiatric symptomatology and the level of severity of alcohol dependence in an inpatient male alcoholic sample, and to describe how this information can be utilized to differentiate large groups of alcoholics into clinical meaningful categories. The study sample was comprised of 100 male alcoholic inpatients from the Alcoholism Treatment Unit at a metropolitan Veterans Administration Hospital. Subjects were administered The Michigan Alcoholism Screening Test (MAST), the Severity of Alcohol Dependence Questionnaire (SADQ), and the Symptom Checklist-90-Revised (SCL-90-R). Correlational analysis of the data supported the hypothesis that a positive relationship exists between the severity of alcohol dependence and the prevalence of additional psychiatric symptom patterns. Partial correlational analysis indicated that the length of the alcoholic's illness and the number of inpatient treatments for alcoholism enhanced the relationship between the severity of alcoholism and most of the symptom scales. The utility of assessing concurrent psychiatric symptomatology as it relates to the severity of alcohol dependence is discussed in relation to treatment planning and prognostic assessment of the patient. JF - The American journal of drug and alcohol abuse AU - Schaefer, M R AU - Sobieraj, K AU - Hollyfield, R L AD - Veterans Administration Edward Hines, Jr. Hospital, Illinois 60141. Y1 - 1987 PY - 1987 DA - 1987 SP - 435 EP - 447 VL - 13 IS - 4 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Mental Disorders -- complications KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77834845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Severity+of+alcohol+dependence+and+its+relationship+to+additional+psychiatric+symptoms+in+male+alcoholic+inpatients.&rft.au=Schaefer%2C+M+R%3BSobieraj%2C+K%3BHollyfield%2C+R+L&rft.aulast=Schaefer&rft.aufirst=M&rft.date=1987-01-01&rft.volume=13&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - High-dose cytosine arabinoside, daunomycin and 6-thioguanine in relapsed or refractory acute nonlymphocytic leukemia. AN - 77827210; 3684173 AB - Fifteen patients with relapsed (10) or primarily refractory (5) acute nonlymphocytic leukemia were treated with a combination of cytosine arabinoside (3 g/m2 i.v. every 12 h, 12 doses, days 1-6), 6-thioguanine (100 mg/m2 orally every 12 h, 12 doses, days 1-6) and daunomycin (60 mg/m2 i.v. on days 5 and 6 only). Complete remission was achieved in 11 patients. Eight of 10 relapsed patients and 3 of 5 primarily refractory patients entered remission. Median remission duration was 7.5 months (2-36+ months). Ten of the 11 remissions resulted from a single induction course. The time to hematologic recovery was comparable to that seen with 'standard'-dose cytosine arabinoside regimens. Nonhematologic toxicity, although considerable, was not greater than that seen with high-dose cytosine arabinoside alone. The most significant problem was gastrointestinal toxicity with diarrhea occurring in the majority of patients. Mild neurologic toxicity (reversible cerebellar dysfunction) occurred in 2 patients. JF - Oncology AU - Garewal, H AU - Durie, B G AU - Greenberg, B AD - Section of Hematology-Oncology, Veterans Administration Medical Center, Tucson, Ariz. Y1 - 1987 PY - 1987 DA - 1987 SP - 333 EP - 335 VL - 44 IS - 6 SN - 0030-2414, 0030-2414 KW - Cytarabine KW - 04079A1RDZ KW - Thioguanine KW - FTK8U1GZNX KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Acute Disease KW - Daunorubicin -- administration & dosage KW - Cerebellar Diseases -- chemically induced KW - Thioguanine -- administration & dosage KW - Humans KW - Thioguanine -- adverse effects KW - Daunorubicin -- adverse effects KW - Gastrointestinal Diseases -- chemically induced KW - Cytarabine -- adverse effects KW - Cytarabine -- administration & dosage KW - Recurrence KW - Remission Induction KW - Leukemia -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77827210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology&rft.atitle=High-dose+cytosine+arabinoside%2C+daunomycin+and+6-thioguanine+in+relapsed+or+refractory+acute+nonlymphocytic+leukemia.&rft.au=Garewal%2C+H%3BDurie%2C+B+G%3BGreenberg%2C+B&rft.aulast=Garewal&rft.aufirst=H&rft.date=1987-01-01&rft.volume=44&rft.issue=6&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Oncology&rft.issn=00302414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - CPAPER T1 - Orderly Endings: The Short-Term Estimability of the Retirement Event T2 - American Sociological Association AN - 61710326; 87S19545 AB - Seeking to describe the subjective (as opposed to statistical) predictability of retirement, the consistency between planned retirement date & actual date was assessed in an panel of older workers, participants in the Veterans Administration Normative Aging Study, who were surveyed about work & retirement in 1978, 1981, & 1984. Over spans of 2 years, 61%-67% of workers could accurately predict their eventual date of retirement (+ 1 year), & 37%-41% were exact to within 3 months. However, approximately 33% misestimated their date of retirement, having either unfulfilled plans or unanticipated retirements. From a life course perspective, retirement can be interpreted as an orderly event when 66% of a sample can retire as planned; but from a practical perspective (eg, an interest in program development or research design), retirement is not orderly when 33% of exits are unscheduled. JF - American Sociological Association AU - Ekerdt, David J AU - Vinick, Barbara H AU - Bosse, Raymond Y1 - 1987///0, PY - 1987 DA - 0, 1987 KW - planned vs actual retirement date, older workers KW - Normative Aging Study KW - Life Stage Transitions KW - Retirement KW - proceeding KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61710326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Sociological+Association&rft.atitle=Orderly+Endings%3A+The+Short-Term+Estimability+of+the+Retirement+Event&rft.au=Ekerdt%2C+David+J%3BVinick%2C+Barbara+H%3BBosse%2C+Raymond&rft.aulast=Ekerdt&rft.aufirst=David&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1987 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Theoretical and Empirical Issues in the Treatment of Post-Traumatic Stress Disorder in Vietnam Veterans AN - 61609363; 198700645 AB - A review of the current status of research on the treatment of combat-related posttraumatic stress disorder (PTSD) in Vietnam war veterans. Dynamic, behavioral, & biochemical models of treatment are presented, along with the findings of relevant treatment outcome studies. Examination of the treatment procedures employed in available studies revealed that direct therapeutic exposure to the memories of trauma emerged as the PTSD treatment technique common to all three theoretical models. The need for controlled investigations of the clinical efficacy of exposure-based interventions for combat-related PTSD is discussed. In addition, several other issues relevant to PTSD treatment research are considered, including (1) the potential utility of studying untrained coping behavior in combat veterans; (2) the effects of using heterogeneous S samples in PTSD treatment research; & (3) the measurement of treatment outcome. 64 References. HA JF - Journal of Clinical Psychology AU - Fairbank, John A AU - Nicholson, Robert A AD - Psychology Service Veterans Administration Medical Center, 1500 East Woodrow Wilson Dr Jackson MS 39216 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 44 EP - 55 VL - 43 IS - 1 SN - 0021-9762, 0021-9762 KW - posttraumatic stress disorder, Vietnam war veterans, treatment issues KW - literature review KW - Psychological Stress KW - Veterans KW - Vietnam War KW - Psychotherapy KW - Combat KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61609363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Theoretical+and+Empirical+Issues+in+the+Treatment+of+Post-Traumatic+Stress+Disorder+in+Vietnam+Veterans&rft.au=Fairbank%2C+John+A%3BNicholson%2C+Robert+A&rft.aulast=Fairbank&rft.aufirst=John&rft.date=1987-01-01&rft.volume=43&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Veterans; Combat; Psychological Stress; Psychotherapy; Vietnam War ER - TY - JOUR T1 - Combat-Related Post-Traumatic Stress Disorder Etiology: Replicated Findings in a National Sample of Vietnam-Era Men AN - 61603526; 198700704 AB - To examine the generality of recent findings on combat-related posttraumatic stress disorders (PTSD) etiology in help-seeking Vietnam war combat veterans, replication was attempted with data from a clinical sample of Vietnam war-era men that included combat veterans (Foy, D. W., et al, "Etiology of Posttraumatic Stress Disorder in Vietnam Veterans: Analysis of Premilitary, Military, and Combat Exposure Influences," Journal of Consulting & Clinical Psychology, 1984, 52, 79-87). Use of a Guttman scaling technique for assessing combat exposure was found to be robust for use with a national nonclinical sample as well (Card, J. J., Lives after Vietnam: The Personal Impact of Military Service, Lexington, Mass: Heath, 1983). In addition, multiple regression analysis was used to examine predictive relationships between premilitary adjustment, military adjustment, combat exposure, & PTSD. Results obtained from the national sample showed the same patterning as that reported from the smaller clinical sample. Combat exposure was related significantly to PTSD symptomatology, while premilitary adjustment was not. A previously identified discriminant function, composed of psychological symptoms not found in the DSM III criteria for PTSD, also was cross-validated. 1 Table, 7 References. Modified HA JF - Journal of Clinical Psychology AU - Foy, David W AU - Card, Josefina J AD - Psychology Service West Los Angeles Veterans Administration Medical Center, Brentwood Division 11301 Wilshire Blvd CA 90073 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 28 EP - 31 VL - 43 IS - 1 SN - 0021-9762, 0021-9762 KW - combat-related posttraumatic stress disorders, Vietnam war veterans, etiological patterning KW - secondary data KW - Veterans KW - Psychological Stress KW - Vietnam War KW - Combat KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61603526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Combat-Related+Post-Traumatic+Stress+Disorder+Etiology%3A+Replicated+Findings+in+a+National+Sample+of+Vietnam-Era+Men&rft.au=Foy%2C+David+W%3BCard%2C+Josefina+J&rft.aulast=Foy&rft.aufirst=David&rft.date=1987-01-01&rft.volume=43&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Veterans; Vietnam War; Combat ER - TY - JOUR T1 - Etiological Factors in the Development of PTSD in Clinical Samples of Vietnam Combat Veterans AN - 61590297; 198700705 AB - A review is presented of empirical literature that deals with etiological factors in combat-related posttraumatic stress disorders (PTSD). Variables implicated in PTSD from three time frames -- premilitary, military, & postmilitary -- are identified, & findings from relevant research are discussed. There is consistency across studies in showing significant correlations between PTSD & combat exposure & postmilitary psychosocial adjustment. Less consistent are the findings with regard to relationships between premilitary psychosocial factors & PTSD. Recent findings from studies that have explored possible physiological correlates of PTSD also are discussed. Based on current literature, implications for future research on etiological factors in combat-related PTSD are presented. 2 Tables, 21 References. HA JF - Journal of Clinical Psychology AU - Foy, David W AU - Carroll, Edward M AU - Donahoe, Clyde P, Jr AD - West Los Angeles Veterans Administration Medical Center, Brentwood Division 11301 Wilshire Blvd CA 90073 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 17 EP - 27 VL - 43 IS - 1 SN - 0021-9762, 0021-9762 KW - combat-related posttraumatic stress disorder, Vietnam war veterans, etiological factors KW - literature review KW - Veterans KW - Psychological Stress KW - Vietnam War KW - Combat KW - Military Service KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Etiological+Factors+in+the+Development+of+PTSD+in+Clinical+Samples+of+Vietnam+Combat+Veterans&rft.au=Foy%2C+David+W%3BCarroll%2C+Edward+M%3BDonahoe%2C+Clyde+P%2C+Jr&rft.aulast=Foy&rft.aufirst=David&rft.date=1987-01-01&rft.volume=43&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Combat; Military Service; Vietnam War; Veterans ER - TY - JOUR T1 - Conducting Applied Research on Vietnam Combat-Related Post-Traumatic Stress Disorder AN - 61590264; 198700553 AB - A paradigmatic shift in posttraumatic stress disorder (PTSD) research is underway. Formistic & mechanistic research designs, characterized by single-category, single-cause, single-effect models, gradually are being replaced by contextual & organistic research designs that feature multicategory, multicause, & multieffect interactional models. Such changes in diagnostic & treatment outcome research require solving many methodological issues in such areas as: (1) measuring types of traumas & stressors; (2) measuring PTSD symptoms & subtypes; (3) measuring subject dispositional characteristics (such as ethnic differences); (4) assessing concurrent &/or preexisting psychiatric (Axis I) disorders; (5) classifying personality styles & concurrent &/or preexisting personality (Axis II) disorders; (6) evaluating phases in the development of PTSD as a disorder; (7) measuring current environmental stresses & interpersonal interactions; & (8) assessing secondary gains & readiness for treatment. These & other methodological problems must be addressed as research on PTSD shifts to longitudinal measurements of Ss randomly assigned to treatment conditions. 1 Table, 40 References. HA JF - Journal of Clinical Psychology AU - Denny, Nathan AU - Robinowitz, Ralph AU - Penk, Walter AD - c/o Penk -- Psychology Service Veterans Administration Medical Center, Boston MA 02130 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 56 EP - 66 VL - 43 IS - 1 SN - 0021-9762, 0021-9762 KW - Vietnam war combat-related posttraumatic stress disorder, applied research, paradigmatic shift KW - Veterans KW - Psychological Stress KW - Vietnam War KW - Combat KW - Theoretical Problems KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Conducting+Applied+Research+on+Vietnam+Combat-Related+Post-Traumatic+Stress+Disorder&rft.au=Denny%2C+Nathan%3BRobinowitz%2C+Ralph%3BPenk%2C+Walter&rft.aulast=Denny&rft.aufirst=Nathan&rft.date=1987-01-01&rft.volume=43&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Combat; Veterans; Vietnam War; Theoretical Problems ER - TY - JOUR T1 - A Patient Dies -- A Social Worker Reviews His Work AN - 61586381; 198901909 AB - A case study of a 59-year-old M with terminal cancer who stayed an unusual length of time (6 months) in the hospital before succumbing to death is presented to illuminate the challenges such cases present to social workers in terms of handling patients' changing needs, capabilities, & limitations. Suggestions for dealing with a patient's family & with the nursing staff are offered, & the difficulty of evaluating social work intervention efforts is discussed. 1 Reference. K. Hyatt JF - Social Work in Health Care AU - Pilsecker, Carleton AD - Veterans Administration Medical Center, 5901 East 7th St Long Beach CA 90822 Y1 - 1987///0, PY - 1987 DA - 0, 1987 SP - 35 EP - 45 VL - 13 IS - 2 SN - 0098-1389, 0098-1389 KW - long-term hospital patient's death, social work intervention efforts KW - case study KW - Client Relations KW - Terminal Illness KW - Social Work Cases KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61586381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=A+Patient+Dies+--+A+Social+Worker+Reviews+His+Work&rft.au=Pilsecker%2C+Carleton&rft.aulast=Pilsecker&rft.aufirst=Carleton&rft.date=1987-01-01&rft.volume=13&rft.issue=2&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work Cases; Client Relations; Terminal Illness ER - TY - JOUR T1 - Engaging the Elderly Couple in Marital Therapy AN - 61551209; 198800862 AB - A continuing increase in the number of US elderly suggests that the marital & family therapist will be dealing with the complex problems of a population who have traditionally underutilized mental health services & who have been viewed by professionals with a negative & stereotypic bias. A method of 'exaggerated engagement' is featured & general assessment & treatment issues involving the older adult in marital therapy are discussed. 1 Figure, 26 References. Modified HA JF - The American Journal of Family Therapy AU - Gafner, George AD - Veterans Administration Medical Center, 3601 South 6th Ave Tucson AZ 85723 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 305 EP - 315 VL - 15 IS - 4 SN - 0192-6187, 0192-6187 KW - US elderly, marital/family therapy issues, "exaggerated engagement" method KW - Conjoint Therapy KW - Elderly KW - United States of America KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61551209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Family+Therapy&rft.atitle=Engaging+the+Elderly+Couple+in+Marital+Therapy&rft.au=Gafner%2C+George&rft.aulast=Gafner&rft.aufirst=George&rft.date=1987-01-01&rft.volume=15&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Family+Therapy&rft.issn=01926187&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Conjoint Therapy; Elderly; United States of America ER - TY - JOUR T1 - Post-Traumatic Stress Disorder: Evidence for Diagnostic Validity and Methods of Psychological Assessment AN - 61539293; 198701107 AB - The diagnosis of posttraumatic stress disorder (PTSD) has been the subject of discussion in clinical literature as to whether it can be discriminated reliably from already existing diagnoses, such as depression, dysthymia, or generalized anxiety disorder. The evidence that surrounds this controversy is reviewed, employing the guidelines for validating a diagnosis established by Robins & S. B. Guze ("Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia," American Journal of Psychiatry, 1970, 126, 983-987) as the framework for the review. A multiaxial approach is presented for the assessment of PTSD that includes the use of structured interviews, psychometrics, & a psychophysiological assessment procedure. Studies that support the reliability & validity of the components of the multiaxial method are reviewed. 42 References. Modified HA JF - Journal of Clinical Psychology AU - Keane, Terence M AU - Wolfe, Jessica AU - Taylor, Kathryn L AD - Boston Veterans Administration Medical Center, MA 02130 Y1 - 1987/01// PY - 1987 DA - January 1987 SP - 32 EP - 43 VL - 43 IS - 1 SN - 0021-9762, 0021-9762 KW - posttraumatic stress disorder, diagnostic validity/assessment approaches KW - Psychological Stress KW - Veterans KW - Diagnosis KW - Combat KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61539293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Post-Traumatic+Stress+Disorder%3A+Evidence+for+Diagnostic+Validity+and+Methods+of+Psychological+Assessment&rft.au=Keane%2C+Terence+M%3BWolfe%2C+Jessica%3BTaylor%2C+Kathryn+L&rft.aulast=Keane&rft.aufirst=Terence&rft.date=1987-01-01&rft.volume=43&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Veterans; Combat; Psychological Stress; Diagnosis ER - TY - JOUR T1 - Spiritual Resources in Older Hospitalized Men AN - 60973344; 88U0720 AB - The spiritual resources of a group of older US Ms facing hospitalization are explored, based on data gathered from questionnaires & semistructured interviews with 80 patients, average age 55, admitted to a Veterans Administration Medical Center in Mass. Despite high levels of stated religiosity (80+% of Rs) & church attendance (57%), less than 10% of Rs showed significant spiritual resources, & less than 5% demonstrated spiritual development above level 2 on the Castle-Kalberg scale. Rs could not easily discuss the development of their faith, nor their inner spiritual experiences. The findings suggest that US churches are failing to provide their adherents with spiritual resources. 1 Table, 10 Figures, 1 Appendix, 33 References. HA Tr & Modified by C. Waters JF - Social Compass AU - McSherry, Elisabeth AU - Salisburg, Steven R AU - Ciulla, Megan R AU - Tsuang, Delbie AD - Veterans Administration Medical Center, Brockton & West Roxbury MA 02401 Y1 - 1987///0, PY - 1987 DA - 0, 1987 SP - 515 EP - 538 VL - 34 IS - 4 SN - 0037-7686, 0037-7686 KW - older hospitalized males, spiritual resources KW - questionnaires, interviews KW - Massachusetts KW - Hospitalization KW - Males KW - Elderly KW - Religious Behavior KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60973344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Compass&rft.atitle=Spiritual+Resources+in+Older+Hospitalized+Men&rft.au=McSherry%2C+Elisabeth%3BSalisburg%2C+Steven+R%3BCiulla%2C+Megan+R%3BTsuang%2C+Delbie&rft.aulast=McSherry&rft.aufirst=Elisabeth&rft.date=1987-01-01&rft.volume=34&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Social+Compass&rft.issn=00377686&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLCSAZ N1 - SubjectsTermNotLitGenreText - Religious Behavior; Males; Hospitalization; Elderly; Massachusetts ER - TY - JOUR T1 - Principles of laboratory isolation and identification of the human immunodeficiency virus (HIV). AN - 20310165; 8928545 AB - Diagnosis of human immunodeficiency virus (HIV) infections has relied most frequently on detecting the presence of HIV antibodies in sera. In many situations, however, patients management can be significantly improved if the presence of HIV can be demonstrated in patients' specimens. In this review, the need and value of HIV isolation for confirming the diagnosis of HIV, for disease staging, and for monitoring the effectiveness of antiviral therapy are discussed. The steps involved in isolation of HIV, the cell systems permissive to HIV growth, and the procedures for virus identification are reviewed. Furthermore, methods available for the direct detection of HIV in patients' specimens are summarized. Although isolation of HIV is presently an elaborate procedure, as easier methods become available, it will play a large role in the management of HIV-infected individuals. Images FIG. 2 FIG. 3 JF - Yale Journal of Biology and Medicine AU - Griffith, B P AD - Virology Reference Laboratory, Veterans Administration Medical Center, West Haven, CT 06516. Y1 - 1987 PY - 1987 DA - 1987 SP - 575 EP - 587 PB - Yale Journal of Biology and Medicine, Inc., 333 Cedar St, PO Box 208000 VL - 60 IS - 6 SN - 0044-0086, 0044-0086 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Antibodies KW - Human immunodeficiency virus KW - Reviews KW - Infection KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20310165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Yale+Journal+of+Biology+and+Medicine&rft.atitle=Principles+of+laboratory+isolation+and+identification+of+the+human+immunodeficiency+virus+%28HIV%29.&rft.au=Griffith%2C+B+P&rft.aulast=Griffith&rft.aufirst=B&rft.date=1987-01-01&rft.volume=60&rft.issue=6&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Yale+Journal+of+Biology+and+Medicine&rft.issn=00440086&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Antibodies; Reviews; Infection; Human immunodeficiency virus ER - TY - JOUR T1 - Treatment of the medial collateral ligament injury. I: The importance of anterior cruciate ligament on the varus-valgus knee laxity AN - 20080270; 10092960 AB - The purpose of this study was to explain the functional roles of the medial collateral ligament (MCL) and the ACL and how they affect the kinematics of the knee joint after isolated MCL injury. Varus-valgus joint laxity was quantitatively measured using a device which al lowed various degrees of freedom (DOF) of joint motion during application of a varus-valgus bending moment to the canine knee joint. When the knee motion was limited to 3 DOF (varus-valgus rotation, proximal-distal, and medial-lateral translation), valgus laxity increased significantly (171%) after sectioning the MCL. Thus, the MCL was the primary restraint to the valgus bending moment in the 3 DOF mode. However, the effect of sectioning the MCL on valgus laxity became minimal (21% increase) when the DOF of knee motion was increased to 5 (by adding axial tibial rotation and ante rior-posterior translation). In this situation, external and internal tibial axial rotation were coupled with the varus and valgus rotation of the knee joint, respectively, and the ACL also functioned to restrain the varus-valgus rotation. The results of this study suggest that under normal knee joint motion, the functional deficit of the MCL in valgus rotation was compensated for by the remaining structures, especially by the ACL. JF - American Journal of Sports Medicine AU - Inoue, Masahiro AU - McGurk-Burleson, Erin AU - Hollis, JMarcus AU - Woo, Savio L-Y AD - Orthopaedic Bioengineering Laboratory, San Diego Veterans Administration Medical Center, the Malcolm and Dorothy Coutts Institute for Joint Reconstruction and Research, and the University of California, San Diego, LaJolla, California Y1 - 1987/01// PY - 1987 DA - Jan 1987 SP - 15 EP - 21 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 15 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Measurement KW - Kinematics KW - Ligaments KW - Injuries KW - Joint stability KW - Knees KW - Sports medicine KW - Movement KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20080270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Treatment+of+the+medial+collateral+ligament+injury.+I%3A+The+importance+of+anterior+cruciate+ligament+on+the+varus-valgus+knee+laxity&rft.au=Inoue%2C+Masahiro%3BMcGurk-Burleson%2C+Erin%3BHollis%2C+JMarcus%3BWoo%2C+Savio+L-Y&rft.aulast=Inoue&rft.aufirst=Masahiro&rft.date=1987-01-01&rft.volume=15&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658701500103 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Kinematics; Measurement; Ligaments; Injuries; Joint stability; Knees; Sports medicine; Movement; Joints DO - http://dx.doi.org/10.1177/036354658701500103 ER - TY - JOUR T1 - Treatment of the medial collateral ligament injury. II: Structure and function of canine knees in response to differing treatment regimens AN - 20078106; 10092961 AB - In order to assess the healing of the medial collateral ligament (MCL) and to detect the various effects of treatment regimens, in vivo animal experiments using a canine model were performed. Thirty-five canine MCLs were surgically transected and treated using three clinically popular regimens, e.g., no repair with cage and farm activities (Group 1), repair with 3 weeks immobilization (Group 2), and repair with 6 weeks im mobilization (Group 3). The varus-valgus laxity of the knee joint, structural properties of the femur-MCL-tibia (FMT) complex and the mechanical properties of the MCL substance (healing site) were quantitatively meas ured at 6, 12, and 48 weeks postoperatively. It was found that Group 1 animals had the best results. The varus-valgus laxity of the knee joint and the structural properties of the FMT complex returned to values comparable with the contralateral control by 12 weeks. The recovery of the mechanical properties of the MCL substance was slower and not complete, even at 48 weeks. In confirmation with previous studies, prolonged immobilization was shown to have deleterious effects on MCL healing. The results of this study indicated that early mobilization is the treatment of choice in cases of isolated MCL injury. Also, this study emphasized the importance and effectiveness of using various biome chanical parameters in addition to the conventional ultimate values at failure to evaluate the progress of soft tissue repair. JF - American Journal of Sports Medicine AU - Woo, Savio L-Y AU - Inoue, Masahiro AU - McGurk-Burleson, Erin AU - Gomez, Mark A AD - Orthopaedic Bioengineering Laboratory, San Diego Veterans Administration Medical Center, Malcolm and Dorothy Coutts Institute for Joint Reconstruction and Research, and the University of California, San Diego, LaJolla, California Y1 - 1987/01// PY - 1987 DA - Jan 1987 SP - 22 EP - 29 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 15 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Ligaments KW - Injuries KW - Recovery KW - Knees KW - Failure KW - Activities KW - Sports medicine KW - Immobilization KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Treatment+of+the+medial+collateral+ligament+injury.+II%3A+Structure+and+function+of+canine+knees+in+response+to+differing+treatment+regimens&rft.au=Woo%2C+Savio+L-Y%3BInoue%2C+Masahiro%3BMcGurk-Burleson%2C+Erin%3BGomez%2C+Mark+A&rft.aulast=Woo&rft.aufirst=Savio&rft.date=1987-01-01&rft.volume=15&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658701500104 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Ligaments; Injuries; Recovery; Knees; Failure; Sports medicine; Activities; Immobilization; Joints DO - http://dx.doi.org/10.1177/036354658701500104 ER - TY - JOUR T1 - The effect of sn-2 fatty acid substitution on phospholipase C enzyme activities. AN - 15176875; 1952905 AB - The human monocyte cell line U937 expresses phospholipase A sub(2) and phospholipase C activities and produces eicosanoids. The phospholipase C (PLC) activity exhibits substrate preference for phosphatidylcholine (PC), rather than phosphatidylinositol or phosphatidylethanolamine. In order to characterize the PLC activity found in these cells, the effects of substitution of the sn-2 fatty acid on this activity were examined. PC substrates with palmitic acid (PC-2P), oleic acid (PC-2O), arachidonic acid (PC-2A) and linoleic acid (PC-2L) at the sn-2 position were used. The data show that the fatty acid constituent at the sn-2 position affects the observed PLC activity when phosphatidylcholine, but not phosphatidylinositol, is used as a substrate by these cells. JF - Biochemical Journal AU - Bomalaski, J S AU - Clark, MA AD - Veterans Administration Med. Cent., 39th and Woodland, Philadelphia, PA 19104, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 497 EP - 502 VL - 244 IS - 3 SN - 0264-6021, 0264-6021 KW - activity KW - fatty acids KW - man KW - monocytes KW - phospholipase C KW - substitution KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15176875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Journal&rft.atitle=The+effect+of+sn-2+fatty+acid+substitution+on+phospholipase+C+enzyme+activities.&rft.au=Bomalaski%2C+J+S%3BClark%2C+MA&rft.aulast=Bomalaski&rft.aufirst=J&rft.date=1987-01-01&rft.volume=244&rft.issue=3&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Biochemical+Journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Seroepidemiologic study of giardiasis patients and high-risk groups in a mid-western city in the United States AN - 13793772; 198800279 AB - The prevalence of serum antibodies to Giardia lamblia among population groups with different types of potential exposure to the parasite were examined. Sequential serum antibody titres in patients who developed giardiasis were monitored in a longitudinal study, G. lamblia serologic data were compared with the frequency of serum antibodies to Entamoeba histolytica. Symptomatic patients had the highest antibody titres, and antibodies remained present for 18 months in chronically infected patients. Indochinese refugees and male homosexuals with AIDS and pre-AIDS had higher mean antibody levels than healthy controls. Sewer and highway maintenance workers had levels similar to those of controls. Serum antibodies to E. histolytica were detected only in a few Indochinese refugees. It was concluded that serology was a promising tool in G. lamblia epidemiology. JF - American Journal of Public Health AU - Sullivan, R AU - Linneman, C C AU - Clark, C S AU - Walzer, P D AD - Veterans Administration Medical Center, Cincinnati, Ohio Y1 - 1987 PY - 1987 DA - 1987 SP - 960 EP - 963 VL - 77 IS - 8 SN - 0090-0036, 0090-0036 KW - Hazard KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13793772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Seroepidemiologic+study+of+giardiasis+patients+and+high-risk+groups+in+a+mid-western+city+in+the+United+States&rft.au=Sullivan%2C+R%3BLinneman%2C+C+C%3BClark%2C+C+S%3BWalzer%2C+P+D&rft.aulast=Sullivan&rft.aufirst=R&rft.date=1987-01-01&rft.volume=77&rft.issue=8&rft.spage=960&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - RPRT T1 - VETERANS ADMINISTRATION NATIONAL CEMETERY NORTHERN CALIFORNIA, ALAMEDA AND MERCED COUNTIES. AN - 15227723; 1158 AB - PURPOSE: A plan to develop a national cemetery in Alameda and Merced counties in northern California is proposed to service the more than 1.0 million veterans that reside in this part of the state. Under the preferred action, the Veterans Administration (VA) proposes to develop a new national cemetery on a 250- to 350-acre parcel of private land located northwest of the town of Santa Nella, California. The site is part of a 25,000-acre ranch and presently provides nonirrigated pasture for cattle. The land would be donated to the VA for use as a cemetery site. An estimated 530,000 veterans reside within the primary service area (50-mile radius) of the site. Based on a projected annual interment rate of 3,181 by the year 2000, required facilities would consist of the following: an administration building, a maintenance building, committal service shelters, a public restroom building, a flagpole and assembly area, a main entrance area, a roadway and parking system, walkways, burial areas (approximately 83,000 total gravesites), a memorial pathway, grading, drainage, landscaping, a utility distribution system, and an irrigation system. The development would be phased, with the first phase involving between 50 and 60 acres. At full build-out, approximately 42 persons would be employed at the proposed cemetery; an interment rate of 12 bodies per day is projected. An alternative site was also considered, as well as a no-action alternative. The alternative site is a 150-acre tract of open space located within the Parks Reserve Forces Training Area near Dublin, California. Although an estimated 870,000 veterans reside in this primary service area and an annual interment rate of 7,264 has been projected by the year 2000, the VA would have to reimburse the U.S. Treasury the "fair market value" to acquire this land. The VA intends to plan the cemetery using elements such as permanent water sites, marsh habitat, and shrub and tree cover to enhance the value of the property as a wildlife habitat, while at the same time providing a scenic setting. POSITIVE IMPACTS: Socioeconomic benefits for the local community would include increased employment (year-round versus seasonal); increased retail sales, especially for restaurants and motels; and revenues from sales taxes. The rolling hills and almond orchards on the site would enhance the visual landscape, as would the construction of the administration building and its access road. No cultural resources and no historic structures or remains were found within the proposed site. NEGATIVE IMPACTS: There would be a slight increase in automobile-related pollutants and in the amount of fertilizers, pesticides, and herbicides in surface water runoff. A reduction of approximately 10 percent would occur in northern Merced County's grazing lands. Some degree of traffic congestion could occur during peak periods for memorial ceremonies on Memorial Day, the Fourth of July, and Veterans' Day weekends. Since McCabe Road is the only access road to the Santa Nella site, it would have to be realigned to remove sharp bends and widened to two 12-foot lanes in order to accommodate increased cemetery traffic. Because statistics show that there is a more than adequate supply of interment space in the area, a new national cemetery could adversely impact the private sector of the interment industry. There would also be a slight decrease in property tax revenues. LEGAL MANDATES: Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.), Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), and Safe Drinking Water Act of 1974, as amended (42 U.S.C. 300(f) et seq.). JF - EPA number: 860515, 272 pages, December 16, 1986 PY - 1986 KW - Land Use KW - Agency number: SCH# 86080507 KW - Buildings KW - Cemeteries KW - Cultural Resources KW - Drainage KW - Employment KW - Grazing KW - Irrigation KW - Land Acquisitions KW - Parking KW - Parks KW - Open Space KW - Roads KW - Socioeconomic Assessments KW - Vegetation KW - Visual Resources KW - Water Quality KW - Water Resources Management KW - Wildlife Habitat KW - California KW - Endangered Species Act of 1973, Plants KW - Federal Water Pollution Control Act of 1972, Compliance KW - National Historic Preservation Act of 1966, Compliance KW - Safe Drinking Water Act of 1974, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15227723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-12-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+ADMINISTRATION+NATIONAL+CEMETERY+NORTHERN+CALIFORNIA%2C+ALAMEDA+AND+MERCED+COUNTIES.&rft.title=VETERANS+ADMINISTRATION+NATIONAL+CEMETERY+NORTHERN+CALIFORNIA%2C+ALAMEDA+AND+MERCED+COUNTIES.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Veterans Administration, Office of Facilities, Washington, D.C.; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: December 16, 1986 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - "Detoxification" of Vietnam War Trauma: A Combined Family-Individual Approach AN - 61550830; 198701845 AB - Treatment with families suffering from the aftereffects of combat trauma in the Vietnam war often requires a preliminary phase of disjoint treatment, in which family members are seen separately, before conjoint treatment can proceed. In this disjoint phase of treatment, wives & children are introduced to the brutal realities of Vietnam combat experience & to an understanding of its sequelae. This disjoint phase of family therapy detoxifies combat experience so that it can be approached in subsequent conjoint sessions along with more traditional family therapy issues. 29 References. HA JF - Family Process AU - Rosenheck, Robert AU - Thomson, Jane AD - Yale Dept Psychiatry West Haven Veterans Administration Medical Center, West Spring St CT 06516 Y1 - 1986/12// PY - 1986 DA - December 1986 SP - 559 EP - 570 VL - 25 IS - 4 SN - 0014-7370, 0014-7370 KW - combat trauma, Vietnam veterans, disjoint family therapy KW - Veterans KW - Psychological Stress KW - Vietnam War KW - Family Therapy KW - Combat KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61550830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Process&rft.atitle=%22Detoxification%22+of+Vietnam+War+Trauma%3A+A+Combined+Family-Individual+Approach&rft.au=Rosenheck%2C+Robert%3BThomson%2C+Jane&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=1986-12-01&rft.volume=25&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Family+Process&rft.issn=00147370&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Combat; Psychological Stress; Vietnam War; Veterans; Family Therapy ER - TY - JOUR T1 - Aluminum-associated bone disease in chronic renal failure: high prevalence in a long-term dialysis population. AN - 77348500; 3503554 AB - Twenty-seven asymptomatic patients treated with hemodialysis longer than 8 years (mean 12.9 +/- 3.1 years) underwent bone biopsy to determine the prevalence of aluminum-associated bone disease. None had excess aluminum exposure from the dialysate. Ten patients (37%) had aluminum-associated bone disease as defined by a bone formation rate (BFR) below normal in the presence of stainable bone aluminum that covered more than 25% of the trabecular surface. The predominant type of bone histology in this group was the aplastic lesion characterized by low bone turnover, a decreased number of osteoblasts, and lack of excess unmineralized osteoid. Osteoblastic osteoid was highly correlated with stainable surface bone aluminum (r = -.82, p less than .001). Among the dynamic bone parameters, the double-tetracycline labeled surface was a more sensitive indicator of impaired bone function than was the bone apposition rate (BAR), since half of the patients with aluminum-associated bone disease had a normal BAR. In all of the biopsies the extent of double-labeled surfaces was inversely proportional to the amount of stainable aluminum on the bone surface (r = -.71, p less than .001), whereas stainable bone aluminum did not correlate with BAR. In seven of the patients with aluminum-associated bone disease, amino-terminal PTH levels were in the normal range while only one patient had a normal plasma mid-region PTH. PTH correlated directly with osteoblastic osteoid, BFR, and double-labeled surfaces. These results indicate that long-term oral aluminum intake in hemodialysis patients results in a high prevalence of aluminum-associated bone disease.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Andress, D L AU - Maloney, N A AU - Endres, D B AU - Sherrard, D J AD - Division of Nephrology, Veterans Administration Medical Center, Seattle, WA. Y1 - 1986/10// PY - 1986 DA - October 1986 SP - 391 EP - 398 VL - 1 IS - 5 SN - 0884-0431, 0884-0431 KW - Parathyroid Hormone KW - 0 KW - Phosphorus KW - 27YLU75U4W KW - Aluminum KW - CPD4NFA903 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Phosphorus -- blood KW - Calcium -- blood KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Biopsy KW - Parathyroid Hormone -- blood KW - Alkaline Phosphatase -- blood KW - Time Factors KW - Male KW - Female KW - Aluminum -- adverse effects KW - Bone Diseases -- epidemiology KW - Bone Diseases -- etiology KW - Aluminum -- blood KW - Kidney Failure, Chronic -- therapy KW - Kidney Failure, Chronic -- complications KW - Renal Dialysis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77348500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Aluminum-associated+bone+disease+in+chronic+renal+failure%3A+high+prevalence+in+a+long-term+dialysis+population.&rft.au=Andress%2C+D+L%3BMaloney%2C+N+A%3BEndres%2C+D+B%3BSherrard%2C+D+J&rft.aulast=Andress&rft.aufirst=D&rft.date=1986-10-01&rft.volume=1&rft.issue=5&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-14 N1 - Date created - 1988-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ego Strength and Achievement Motivation in Pathological Gamblers AN - 60975897; 88T2919 AB - It is argued that there are a priori reasons to extract measures of ego strength & achievement motivation from the psychometric database routinely collected from inpatient pathological gamblers in order to clarify the meaning of these constructs & to evaluate their roles in personality organization. A sample of 57 Ss engaged in a a Cleveland, Ohio, inpatient treatment program for pathological gamblers in 1981/82 was studied using an ego stength scale & 2 measures of achievement motivation. Compared to the standardization group norms on these instruments, pathological gamblers are significantly deficient in both ego strength & one type of achievement motivation. Clinical impressions of gamblers in treatment suggest that narcissistic characteristics are a major problem in treatment & that future research should attempt further detailed studies of ego structure in order to refine treatment objectives. 46 References. Modified HA JF - Journal of Gambling Behavior AU - Taber, Julian I AU - Russo, Angel M AU - Adkins, Bonnie J AU - McCormick, Richard A AD - Veterans Administration Medical Center, 116B 1000 Locust St Reno Nevada 89520 Y1 - 1986/10// PY - 1986 DA - October 1986 SP - 69 EP - 80 VL - 2 IS - 2 SN - 0742-0714, 0742-0714 KW - pathological gamblers, personality organization KW - scales KW - gamblers, treatment program, Cleveland, Ohio KW - 1983/82 KW - Personality Traits KW - Gambling KW - Treatment Programs KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60975897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gambling+Behavior&rft.atitle=Ego+Strength+and+Achievement+Motivation+in+Pathological+Gamblers&rft.au=Taber%2C+Julian+I%3BRusso%2C+Angel+M%3BAdkins%2C+Bonnie+J%3BMcCormick%2C+Richard+A&rft.aulast=Taber&rft.aufirst=Julian&rft.date=1986-10-01&rft.volume=2&rft.issue=2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gambling+Behavior&rft.issn=07420714&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGBEES N1 - SubjectsTermNotLitGenreText - Gambling; Treatment Programs; Personality Traits ER - TY - JOUR T1 - Identification of Dysarthria Types Based on Perceptual Analysis AN - 58100890; 8802171 AB - Reported is a study investigating the accuracy with which three groups of listeners could use perceptual analysis alone for identification of specific dysarthria types. The disarthria types to be identified were those described by F. Darly, A. Aronson, & J. Brown (see LLBA III/4, p. 1576): Flaccid, Spastic, Ataxic, Hypokinetic, Hyperkinetic Chorea, Hyperkinetic Dystonia, & Mixed. Listener group 1 consisted of clinical speech pathologists with at least five years' experience (N = 17). Listener group 2 (N = 11) had the same background, but were given different methods of rating the speech samples. Listener group 3 (N = 15) consisted of speech/lang pathology graduate students. All groups showed minimal success in accurate identification of specific dysarthria types. Factors that may have contributed to this poor success are discussed, & it is suggested that perceptual analysis alone does not provide sufficiently accurate diagnosis. 5 Tables, 26 References. Modified HA JF - Journal of Communication Disorders AU - Zyski, Barbara Jean AU - Weisiger, Bradford E AD - c/o Weisiger-Audiology & Speech Pathology Section 126 Veterans Administration Medical Center, 3200 Vine St Cincinnati OH 45220 Y1 - 1986/10// PY - 1986 DA - October 1986 SP - 367 EP - 378 VL - 20 IS - 5 SN - 0021-9924, 0021-9924 KW - dysarthria types identification, perceptual analysis KW - diagnosis accuracy challenged KW - Speech Perception (sp6) KW - Language Pathology (la4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58100890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Identification+of+Dysarthria+Types+Based+on+Perceptual+Analysis&rft.au=Zyski%2C+Barbara+Jean%3BWeisiger%2C+Bradford+E&rft.aulast=Zyski&rft.aufirst=Barbara&rft.date=1986-10-01&rft.volume=20&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Speech Perception (sp6) ER - TY - JOUR T1 - Monoclonal Antibodies Cross-Reactive with Group A Streptococci and Normal and Psoriatic Human Skin AN - 907166974; 15080791 AB - Infection with group A streptococci has been implicated as a factor capable of exacerbating psoriasis. In order to explore the possibility of cross-reactivity between streptococcal antigens and human skin in this phenomenon, skin from psoriatic patients and control subjects was reacted with 3 monoclonal antibodies against group A streptococci and antibody binding was estimated by the indirect immunofluorecence technique. Monoclonal antibody 54.2.8 stained the nuclei and cytoplasm of cells within the epidermis and epidermal appendages, as well as cells scattered throughout the dermis. In contrast, monoclonal antibodies 49.8.2 and 36.2.2 labeled the cytoplasm of epidermal cells and epidermal appendages but did not react with nuclei. No difference in the staining patterns of control skin and uninvolved skin from patients with psoriasis was observed. However, skin from psoriatic lesions contained large amounts of cross-reactive skin component(s). Sera from patients with guttate psoriasis did not react differently with normal or psoriatic skin when compared with normal sera. Western immunoblots of skin extracts demonstrated that monoclonal antibody 54.2.8 reacted with a family of proteins in the molecular weight range of 60-70K. The results indicate that component(s) in human skin share cross-reactive epitopes with group A streptococci. Immunologic cross-reactions between group A streptococci and human skin may play an important role in the exacerbation of certain skin disorders following streptococcal infections.Journal of Investigative Dermatology (1986) 87, 367-371; doi:10.1111/1523-1747.ep12524838 JF - Journal of Investigative Dermatology AU - Swerlick, Robert A AU - Cunningham, Madeleine W AU - Hall, Nancy K AD - [1] 1 Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, U.S.A. [2] 2 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, U.S.A. [3] 3 Veterans Administration Medical Center, Oklahoma City, Oklahoma, U.S.A. Y1 - 1986/09// PY - 1986 DA - Sep 1986 SP - 367 EP - 371 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 87 IS - 3 SN - 0022-202X, 0022-202X KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Dermis KW - Cross-reactivity KW - Skin KW - Cross-reaction KW - Monoclonal antibodies KW - Dermatology KW - Infection KW - Epidermis KW - Skin diseases KW - Psoriasis KW - Molecular weight KW - Cytoplasm KW - Nuclei KW - Epitopes KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907166974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Investigative+Dermatology&rft.atitle=Monoclonal+Antibodies+Cross-Reactive+with+Group+A+Streptococci+and+Normal+and+Psoriatic+Human+Skin&rft.au=Swerlick%2C+Robert+A%3BCunningham%2C+Madeleine+W%3BHall%2C+Nancy+K&rft.aulast=Swerlick&rft.aufirst=Robert&rft.date=1986-09-01&rft.volume=87&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Investigative+Dermatology&rft.issn=0022202X&rft_id=info:doi/10.1111%2F1523-1747.ep12524838 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Dermis; Skin; Cross-reactivity; Monoclonal antibodies; Cross-reaction; Dermatology; Infection; Epidermis; Skin diseases; Psoriasis; Cytoplasm; Molecular weight; Nuclei; Epitopes; Streptococcus DO - http://dx.doi.org/10.1111/1523-1747.ep12524838 ER - TY - JOUR T1 - Forskolin has both stimulatory and inhibitory effects on bone resorption in fetal rat long bone cultures. AN - 77347821; 2459910 AB - The diterpene forskolin which increases 3',5'-cyclic adenosine monophosphate concentrations (cAMP) in intact cells by directly activating the enzyme adenyl cyclase, was examined for its ability to alter bone resorption in fetal rat long bone cultures. After 48 h, forskolin inhibited resorption at 1.0 and 10 microM. However, after 120 h, it had a small stimulatory effect at 1.0 microM and no net effect on resorption at 10 microM. Isobutyl-methylxanthine (IBMX), which elevates cAMP levels in cells by inhibiting the enzyme 3',5'-cyclic adenosine monophosphate phosphodiesterase, produced a resorptive response which was slightly different from that of forskolin. After both 48 and 120 h, IBMX at 0.1 mM stimulated resorption while at 1.0 mM, it had only inhibitory effects. In bones which were stimulated to resorb with either parathyroid hormone or 1,25(OH)2 vitamin D, forskolin inhibited resorption. The inhibitory effects of forskolin on hormonally stimulated resorption were transient in cultures treated with 1.0 microM but were sustained with 10 microM. Inhibitory responses to forskolin did not appear to result from toxicity since they were completely reversed when forskolin was removed from the media. These results imply that agents which increases 3',5'-cyclic adenosine monophosphate concentrations in bone activate two resorptive pathways: one which is inhibitory and another which is stimulatory. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Lorenzo, J A AU - Sousa, S AU - Quinton, J AD - Division of Endocrinology and Metabolism, Newington Veterans Administration Medical Center, CT 06111. Y1 - 1986/08// PY - 1986 DA - August 1986 SP - 313 EP - 317 VL - 1 IS - 4 SN - 0884-0431, 0884-0431 KW - Parathyroid Hormone KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - Cyclic AMP KW - E0399OZS9N KW - Calcium KW - SY7Q814VUP KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Index Medicus KW - Rats KW - Calcium -- metabolism KW - Animals KW - Parathyroid Hormone -- pharmacology KW - Cyclic AMP -- analysis KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Organ Culture Techniques KW - Bone and Bones -- embryology KW - Colforsin -- pharmacology KW - Bone Resorption -- drug effects KW - Bone Development -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77347821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Forskolin+has+both+stimulatory+and+inhibitory+effects+on+bone+resorption+in+fetal+rat+long+bone+cultures.&rft.au=Lorenzo%2C+J+A%3BSousa%2C+S%3BQuinton%2C+J&rft.aulast=Lorenzo&rft.aufirst=J&rft.date=1986-08-01&rft.volume=1&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-14 N1 - Date created - 1988-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - More Thoughts on the Fragmentation of Medical Anthropology AN - 60977211; 87R8524 AB - A critique of Hans A. Baer's article, "The Replication of the Medical Division of Labor in Medical Anthropology: Implications for the Field" (see SA 34:3/87R5404). It is argued that Baer misunderstands the fragmentation of medical anthropology & attributes anthropologists' motivations for moving into biomedical work as resulting from the lack of academic jobs. Rather, the acquisition of biomedical skills occurs for positive reasons other then economic self-interest, & the loosening of ties between academic & medical anthropologists is more of a threat to the unity of the discipline than is employment in biomedical fields. In And a Response $..., Hans A. Baer (U of Arkansas, Little Rock) agrees that altruism & other motives may motivate anthropologists to work in applied areas, but laments the emphasis on biomedical over broader social science knowledge. This tendency impairs clinical anthropologists' ability to link macroscopic with microscopic issues & decreases their impact on the existing organization of health care. K. Carande JF - Medical Anthropology Quarterly AU - Wieland, G Darryl AD - Veterans Administration Medical Center, 16111 Plummer St Sepulveda CA 91343 Y1 - 1986/08// PY - 1986 DA - August 1986 SP - 99 EP - 100 VL - 17 IS - 4 KW - medical anthropology, clinical vs academic work, discipline fragmentation KW - critique/reply KW - Anthropology KW - Medical Research KW - Methodological Problems KW - Distance Education KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60977211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Anthropology+Quarterly&rft.atitle=More+Thoughts+on+the+Fragmentation+of+Medical+Anthropology&rft.au=Wieland%2C+G+Darryl&rft.aulast=Wieland&rft.aufirst=G&rft.date=1986-08-01&rft.volume=17&rft.issue=4&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Medical+Anthropology+Quarterly&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - SuppNotes - Rejoinder, 100. N1 - Last updated - 2016-09-28 N1 - CODEN - MAQUD5 N1 - SubjectsTermNotLitGenreText - Medical Research; Distance Education; Anthropology; Methodological Problems ER - TY - JOUR T1 - Susceptibility of Members of the Family Legionellaceae to Thermal Stress: Implications for Heat Eradication Methods in Water Distribution Systems AN - 19007864; 8707600 AB - The feasibility of heat inactivation as an eradication method applicable to all members of the family Legionellaceae was tested using 75 isolates representing 19 members of the family. The ranges of death times at 60, 70, and 80 C were 1.3-10.6, 0.7-2.6, and 0.3-0.7 min, respectively. It is concluded that heat eradication should be effective against all members of the Legionellaceae. The heat resistance of Legionella pneumophila serogroup 1, the most common pathogen in the family, was assessed in greater detail, using conditions found in hospital water systems. The thermal stabilities of two environmental strains of this serogroup were found to be virtually unaffected when heat resistance was determined in broth, water, or water containing particulates. (Author 's abstract) JF - Applied and Environmental Microbiology AEMIDF Vol. 52, No. 2, p 396-399, August 1986. 1 fig, 1 tab, 17 ref. AU - Stout, JE AU - Best, M G AU - Yu, V L AD - Veterans Administration Medical Center Pittsburgh, PA. Special Pathogens Section Y1 - 1986/08// PY - 1986 DA - Aug 1986 KW - Water Resources Abstracts KW - Legionella KW - Thermal stress KW - Water treatment KW - Water conveyance KW - Sterilization KW - Public health KW - Temperature effects KW - Stress KW - Bacteria KW - Pathogenic bacteria KW - Hospitals KW - SW 3060:Water treatment and distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19007864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Susceptibility+of+Members+of+the+Family+Legionellaceae+to+Thermal+Stress%3A+Implications+for+Heat+Eradication+Methods+in+Water+Distribution+Systems&rft.au=Stout%2C+JE%3BBest%2C+M+G%3BYu%2C+V+L&rft.aulast=Stout&rft.aufirst=JE&rft.date=1986-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - VETERANS ADMINISTRATION MEDICAL CENTER, ALLEN PARK, MICHIGAN. AN - 36394440; 903 AB - PURPOSE: Modernization or replacement of the existing Veterans Administration Medical Center (VAMC) at Allen Park, Michigan is proposed. The existing VAMC is severely deficient in both current medical program functions and space to provide the required levels of health care services to eligible veterans. The objective of this project will be to correct all or as many of the deficiencies as possible in renovated space or by new construction. The preferred alternative would include a 641-bed replacement hospital on a site adjacent to the Detroit Medical Center. The conceptual design would include building space, mixed with surface and structured parking and green space, to accommodate the 641-bed facility comprised of 521 medical and surgical beds and 120 nursing-home-care beds. The proposed site comprises 18.7 acres situated directly to the west of the Detroit Medical Center. The area encompasses three contiguous city blocks and includes the east-west cross streets of Forest and Garfield. The area is primarily residential in nature, containing 301 residential units. POSITIVE IMPACTS: Constructing the replacement VAMC adjacent to the Detroit Medical Center and to the Wayne State University School of Medicine may result in a savings of up to 34,700 hours of physician and medical practitioner time and 14,300 hours of research-intern and VA staff time that now is spent in commuting between the medical centers in Detroit and Allen Park. Due to the geographic location of the veteran population with respect to the alternative sites, an estimated 40,000 hours of patient automobile travel time per year might be saved with implementation of the relocation alternatives. It is projected that from 2,600 to 3,000 person-years of temporary employment would be generated by the construction of the 641-bed alternative. An additional 24 person-years of demolition employment would be created to clear the Detroit site. The new VAMC within the already large Detroit Medical Center would add a sizable increment to the activity and prestige surrounding the entire medical and educational center. NEGATIVE IMPACTS: Relocation of the VAMC would cause a slight increase in potential water runoff at the Detroit site. The proposed relocation to Detroit would result in the demolition of more than 100 residential structures, garages, and some commercial space, representing an estimated 10,000 cubic yards of demolition material. Implementation of the relocation alternative would result in relocating approximately 450 residents and 8 small businesses within the area of the Detroit site. Relocating to Detroit would increase traffic flows along Hancock between John R and Brush streets by more than 300 percent. LEGAL MANDATES: Clean Air Act of 1963, as amended (P.L. 88-206), Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.), Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft environmental impact statement (DEIS) and the draft supplement to the DEIS, see 84-0447D, Volume 8, Number 9, and 85-0487D, Volume 9, Number 10, respectively. JF - EPA number: 860298, 442 pages, July 22, 1986 PY - 1986 KW - Urban and Social Programs KW - Air Quality KW - Employment KW - Historic Sites KW - Hospitals KW - Landfills KW - Parking KW - Relocations-Property Acquisitions KW - Traffic Control KW - Urban Renewal KW - Water Quality KW - Michigan KW - Clean Air Act of 1963, Emission Standards KW - Endangered Species Act of 1973, Compliance KW - Federal Water Pollution Control Act of 1972, NPDES Permits KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36394440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-07-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+ALLEN+PARK%2C+MICHIGAN.&rft.title=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+ALLEN+PARK%2C+MICHIGAN.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Veterans Administration, Office of Construction, Washington, D.C.; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Final. Preparation date: July 22, 1986 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Outpatient Treatment of Patients with Substance Abuse and Coexisting Psychiatric Disorders AN - 61609948; 198701176 AB - Thirty-two patients with coexisting substance abuse & other psychiatric disorders were treated in a unique outpatient pilot program that used techniques drawn from both psychiatric & substance abuse treatment. Eleven patients remained in treatment for 3+ months, & 7 completed 1+ years of treatment. Severity of associated psychiatric illness did not affect retention in treatment. Drug-abusing patients & those with personality disorders dropped out quickly; patients with a history of reliable outpatient treatment involvement tended to remain in treatment. Treatment retention was associated with reduced hospital utilization. Guidelines are suggested for management of patients with coexisting substance abuse & other psychiatric disorders. 2 Tables, 35 References. HA JF - The American Journal of Psychiatry AU - Kofoed, Lial AU - Kania, Joyce AU - Walsh, Thomas AU - Atkinson, Roland M AD - Portland Veterans Administration Medical Center (116A-P), PO Box 1034 OR 97207 Y1 - 1986/07// PY - 1986 DA - July 1986 SP - 867 EP - 872 VL - 143 IS - 7 SN - 0002-953X, 0002-953X KW - substance abuse-psychiatric disorders, outpatient treatment approach KW - case records KW - Outpatients KW - Mental Patients KW - Substance Abuse KW - Treatment Programs KW - After Care KW - Program Evaluation KW - Recidivism KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61609948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Outpatient+Treatment+of+Patients+with+Substance+Abuse+and+Coexisting+Psychiatric+Disorders&rft.au=Kofoed%2C+Lial%3BKania%2C+Joyce%3BWalsh%2C+Thomas%3BAtkinson%2C+Roland+M&rft.aulast=Kofoed&rft.aufirst=Lial&rft.date=1986-07-01&rft.volume=143&rft.issue=7&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Patients; Outpatients; After Care; Recidivism; Substance Abuse; Program Evaluation; Treatment Programs ER - TY - JOUR T1 - Aged 80 and Older Women and Men Take the Initiative to Sustain Self Conceptions AN - 60968987; 87R8623 AB - Although persons aged 80+ are the fastest increasing age group within the elderly population in industrialized nations, only recently has this segment of the population begun to command research attention. Results are presented of an 18-month exploratory interview study of 28 Ms & Fs aged 80+, from a range of educational & SE backgrounds; discussed from the Ss' perspective are: (1) the personal & social meanings associated with being old & their responses to these meanings, (2) the strategic use of the past & its meaning for the present, & (3) their efforts to effect a positive perception of themselves by others in social situations. The implications of these findings for health professionals are noted. 33 References. Modified HA JF - Home Health Care Services Quarterly AU - Davis, Marcella Z AD - Veterans Administration Medical Center San Diego, 3350 La Jolla Village Dr CA 92161 Y1 - 1986/07// PY - 1986 DA - July 1986 SP - 71 EP - 91 VL - 7 IS - 2 SN - 0162-1424, 0162-1424 KW - self conceptions/perceptions, elderly aged 80+ KW - interviews KW - Self Concept KW - Elderly KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60968987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Services+Quarterly&rft.atitle=Aged+80+and+Older+Women+and+Men+Take+the+Initiative+to+Sustain+Self+Conceptions&rft.au=Davis%2C+Marcella+Z&rft.aulast=Davis&rft.aufirst=Marcella&rft.date=1986-07-01&rft.volume=7&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Services+Quarterly&rft.issn=01621424&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HHCQDJ N1 - SubjectsTermNotLitGenreText - Elderly; Self Concept ER - TY - JOUR T1 - Professionalism, Bureaucracy and Patriotism: The VA as a Health Care Megasystem AN - 1463021285; 198701844 AB - Distinctive features of the Veterans Administration (VA) health care megasystem are described. Experiences & concerns of health care professionals are related, & broader implications of the problems illustrated are discussed. A three-dimensional view of the VA is proposed that encompasses its primary task, social structure, & organizational culture. 43 References. Modified HA JF - Psychiatric Quarterly AU - Rosenheck, Robert AD - 116A Psychiatry Service West Haven Veterans Administration Medical Center, West Spring St CT 16511 Y1 - 1986/07// PY - 1986 DA - July 1986 SP - 77 EP - 90 VL - 58 IS - 2 SN - 0033-2720, 0033-2720 KW - Veterans Administration health care megasystem, organizational structure KW - Veterans KW - Health Care KW - Government Agencies KW - Organizational Structure KW - United States of America KW - Hospitals KW - article KW - 6110: social services delivery systems/administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463021285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=Professionalism%2C+Bureaucracy+and+Patriotism%3A+The+VA+as+a+Health+Care+Megasystem&rft.au=Rosenheck%2C+Robert&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=1986-07-01&rft.volume=58&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Government Agencies; United States of America; Health Care; Organizational Structure; Veterans; Hospitals ER - TY - JOUR T1 - Social Support Factor Structure in the Elderly AN - 60925882; 87T0772 AB - The factor structure of social support measures are examined via analysis of structured interview data from a randomly selected sample of 210 elderly members of the patient population served by a Pitt County, NC, family practice center. Four measures selected to operationalize socioemotional & instrumental support were administered along with demographic, health status, & life satisfaction measures. A principal axes factor analysis followed by oblique rotation generated a 4-factor solution: (1) support intensity, (2) social contacts, (3) social resource availability, & (4) telephone contacts. These desired factors provide additional confirmation that social support is a multidimensional construct. 4 Tables, 29 References. Modified HA JF - Research on Aging AU - Revicki, Dennis A AU - Mitchell, Jim AD - Veterans Administration, Perry Point MD 21902 Y1 - 1986/06// PY - 1986 DA - June 1986 SP - 232 EP - 248 VL - 8 IS - 2 SN - 0164-0275, 0164-0275 KW - social support, elderly, multidimensional factor structure KW - interviews KW - family practice center, Pitt County, North Carolina KW - Elderly KW - Life Satisfaction KW - Social Support KW - Measures (Instruments) KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60925882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+on+Aging&rft.atitle=Social+Support+Factor+Structure+in+the+Elderly&rft.au=Revicki%2C+Dennis+A%3BMitchell%2C+Jim&rft.aulast=Revicki&rft.aufirst=Dennis&rft.date=1986-06-01&rft.volume=8&rft.issue=2&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Research+on+Aging&rft.issn=01640275&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - REAGDY N1 - SubjectsTermNotLitGenreText - Elderly; Social Support; Measures (Instruments); Life Satisfaction ER - TY - JOUR T1 - Paleoepidemiologic Investigation of Legionnaires Disease at Wadsworth Veterans Administration Hospital by Using Three Typing Methods for Comparison of Legionellae from Clinical and Environmental Sources AN - 18995013; 8700276 AB - Multilocus enzyme electrophoresis, monoclonal antibody typing for Legionella pneumophila serogroup 1, and plasmid analysis were used to type 89 L pneumophila strains isolated from nosocomial cases of Legionnaires disease at the Veterans Administration Wadsworth Medical Center (VAWMC, Los Angeles) and from the hospital environment. Twelve L pneumophila clinical isolates, obtained from patients at non-VAWMC hospitals, were also typed by the same methods. Most (79%) of 33 VAWMC L pneumophila serogroup 1 clinical isolates and 70% of 23 environmental isolates were found in only one of the five monoclonal subgroups. Similar clustering was found for the other two typing methods, with excellent correlation between all methods. Enzyme electrophoretic typing divided the isolates into the greatest number of distinct groups, resulting in the identification of 10 different L. pneumophila types and 5 types not belonging to L. pneumophila, which probably constitute an undescribed Legionella species. Seven clinical and 34 environmental VAWMC isolates and 2 non-VAWMC clinical isolates were found to be members of the new species. Twelve different plasmid patterns were found; 95% of VAWMC clinical isolates contained plasmids. Major VAWMC epidemic-bacterial types were common in the hospital potable-water distribution system and cooling tower. Strains of L. pneumophila that persisted after disinfection of contaminated environmental sites were of a different type from the prechlorination strains. (Rochester-PTT) JF - Journal of Clinical Microbiology JCMIDW Vol. 23, No. 6, p 1121-1126, June 1986. 4 tab, 22 ref. AU - Edelstein, PH AU - Nakahama, C AU - Tobin, JO AU - Calarco, K AU - Beer, K B AD - Veterans Administration Wadsworth Medical Center Los Angeles, CA Y1 - 1986/06// PY - 1986 DA - Jun 1986 KW - Water Resources Abstracts KW - Paleoepidemiology KW - Wadsworth Veterans Administration Hospital KW - Enzyme electrophoresis KW - Monoclonal antibodies KW - Plasmids KW - Potable water KW - Cooling water KW - Chlorination KW - Epidemiology KW - Los Angeles KW - California KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18995013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Paleoepidemiologic+Investigation+of+Legionnaires+Disease+at+Wadsworth+Veterans+Administration+Hospital+by+Using+Three+Typing+Methods+for+Comparison+of+Legionellae+from+Clinical+and+Environmental+Sources&rft.au=Edelstein%2C+PH%3BNakahama%2C+C%3BTobin%2C+JO%3BCalarco%2C+K%3BBeer%2C+K+B&rft.aulast=Edelstein&rft.aufirst=PH&rft.date=1986-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Reasons for Low Utilization of Mental Health Services by the Elderly AN - 1463021537; 198701243 AB - Some reasons for the low utilization of mental health services by the US elderly are explored, with focus on three interrelated barriers to treatment: (1) professional attitudes & biases; (2) the elderly's attitudes & fears; & (3) practical limitations, eg, transportation, finances, organizational unresponsiveness, & lack of training, research, & outreach efforts by service facilities. It is concluded that chronological age may be less of a factor in underutilization than differences in attitudes, values, & belief systems that prevent the elderly from seeking care. 47 References. K. Hyatt JF - Clinical Gerontologist AU - Lasoski, Milton C AD - Psychology Dept 116B Veterans Administration Medical Center, Fort Lyon CO 81038 Y1 - 1986/06// PY - 1986 DA - June 1986 SP - 1 EP - 18 VL - 5 IS - 1-2 SN - 0731-7115, 0731-7115 KW - mental health service underutilization, elderly, US KW - Elderly KW - Mental Health KW - Health Care Utilization KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463021537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Reasons+for+Low+Utilization+of+Mental+Health+Services+by+the+Elderly&rft.au=Lasoski%2C+Milton+C&rft.aulast=Lasoski&rft.aufirst=Milton&rft.date=1986-06-01&rft.volume=5&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Health Care Utilization; Mental Health ER - TY - JOUR T1 - Ex-vivo isolated perfusion of the pancreas in the Syrian golden hamster. AN - 77333896; 3693978 AB - The technique of ex-vivo isolated pancreatic perfusion has been a valuable method for investigation of the physiology of the exocrine and endocrine pancreas. We have adapted the technique of isolated pancreatic perfusion for use in the Syrian golden hamster, an animal used widely in studies of pancreatic carcinogenesis. The technique involves surgical harvest of the pancreas with its aortic and portal venous blood supply intact and perfusion of the pancreas with a modified Krebs buffer at 37 degrees C. Physiological function of the perfused pancreas system was examined in 27 Syrian hamsters. In tests of endocrine function, the perfused pancreas responded by increasing insulin secretion within 1 min of elevating perfusate glucose concentration, and also secreted insulin promptly in response to 10 mM arginine. In exocrine studies, the flow of pancreatic juice was stimulated by the addition of 0.8 X 10(-9) M secretin to the perfusate, and amylase output was significantly increased by the addition of 0.2 X 10(-9) M cholecystokinin (CCK-8). The ex-vivo isolated perfused pancreas in the hamster thus appears to respond appropriately to physiological stimuli and is a valuable additional tool for studies of the hamster pancreas. JF - International journal of pancreatology : official journal of the International Association of Pancreatology AU - Bell, R H AU - Place, S AU - McCullough, P AU - Ray, M B AU - Rogers, D H AD - Veterans Administration Medical Center, Department of Surgery, Cincinnati, OH 45220. Y1 - 1986/05// PY - 1986 DA - May 1986 SP - 71 EP - 81 VL - 1 IS - 1 SN - 0169-4197, 0169-4197 KW - Index Medicus KW - Animals KW - Reference Values KW - Perfusion KW - Organ Culture Techniques -- methods KW - Mesocricetus KW - Male KW - Cricetinae KW - Pancreas -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77333896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.atitle=Ex-vivo+isolated+perfusion+of+the+pancreas+in+the+Syrian+golden+hamster.&rft.au=Bell%2C+R+H%3BPlace%2C+S%3BMcCullough%2C+P%3BRay%2C+M+B%3BRogers%2C+D+H&rft.aulast=Bell&rft.aufirst=R&rft.date=1986-05-01&rft.volume=1&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology&rft.issn=01694197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ultrasound Visualization of Abruptio Placentae with Massive Hemorrhage Protruding into the Amniotic Cavity AN - 21270496; 11625083 JF - Journal of Diagnostic Medical Sonography AU - Price, Susan A AD - Veterans Administration Medical Center, Division of Diagnostic Ultrasound, V-114/A, 3350 La Jolla Village Drive, San Diego, CA 92161 Y1 - 1986/05// PY - 1986 DA - May 1986 SP - 161 EP - 163 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 3 SN - 8756-4793, 8756-4793 KW - Biotechnology and Bioengineering Abstracts KW - Cavities KW - Hemorrhage KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21270496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Diagnostic+Medical+Sonography&rft.atitle=Ultrasound+Visualization+of+Abruptio+Placentae+with+Massive+Hemorrhage+Protruding+into+the+Amniotic+Cavity&rft.au=Price%2C+Susan+A&rft.aulast=Price&rft.aufirst=Susan&rft.date=1986-05-01&rft.volume=2&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+Diagnostic+Medical+Sonography&rft.issn=87564793&rft_id=info:doi/10.1177%2F875647938600200309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cavities; Hemorrhage; Ultrasound DO - http://dx.doi.org/10.1177/875647938600200309 ER - TY - JOUR T1 - Abnormal calcium metabolism caused by increased circulating 1,25-dihydroxyvitamin D in a patient with rheumatoid arthritis. AN - 77356553; 3503540 AB - A 35-year-old white male with rheumatoid arthritis who had developed hypercalcemia, hypercalciuria, and nephrolithiasis was found to be abnormally sensitive to vitamin D as a result of lack of regulation of circulating 1,25-dihydroxyvitamin D (1,25-(OH)2D). An increase in daily intake of vitamin D from 10 micrograms (400 units) per day to 50 micrograms (2000 units) per day produced an abnormal elevation in serum 1,25-(OH)2D, hypercalcemia, and hypercalciuria which were corrected by prednisone. Serum 25-hydroxyvitamin D initially was abnormally low, and increased with vitamin D to values which were in the low normal range. There were significant positive correlations between serum 1,25-(OH)2D (p less than .05) and serum calcium and between serum 1,25-(OH)2D and urinary calcium (p less than .05). Serum immunoreactive parathyroid hormone, initially in the lower range of normal, decreased further during hypercalcemia. A radiograph of the chest, gallium scan, and serum angiotensin-converting enzyme activity were normal. No granulomas or evidence of lymphoma were found in biopsies of the liver and of several lymph nodes. It is concluded that the abnormal calcium metabolism in this patient resulted from increased circulating 1,25-(OH)2D and that the defect in vitamin D metabolism was not related to sarcoidosis, other granulomatous disease, Hodgkin's disease, or lymphoma. The relationship, if any, of the abnormal metabolism of vitamin D and calcium to rheumatoid arthritis remains to be established. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Gates, S AU - Shary, J AU - Turner, R T AU - Wallach, S AU - Bell, N H AD - Veterans Administration Medical Center, Albany, NY. Y1 - 1986/04// PY - 1986 DA - April 1986 SP - 221 EP - 226 VL - 1 IS - 2 SN - 0884-0431, 0884-0431 KW - Parathyroid Hormone KW - 0 KW - Vitamin D KW - 1406-16-2 KW - Phosphorus KW - 27YLU75U4W KW - Creatinine KW - AYI8EX34EU KW - Calcitriol KW - FXC9231JVH KW - Calcium KW - SY7Q814VUP KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Prednisone -- pharmacology KW - Phosphorus -- blood KW - Hypercalcemia -- complications KW - Humans KW - Adult KW - Vitamin D -- adverse effects KW - Parathyroid Hormone -- blood KW - Creatinine -- blood KW - Male KW - Calcium -- metabolism KW - Calcium -- blood KW - Calcium -- urine KW - Calcitriol -- blood KW - Arthritis, Rheumatoid -- metabolism KW - Arthritis, Rheumatoid -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77356553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Abnormal+calcium+metabolism+caused+by+increased+circulating+1%2C25-dihydroxyvitamin+D+in+a+patient+with+rheumatoid+arthritis.&rft.au=Gates%2C+S%3BShary%2C+J%3BTurner%2C+R+T%3BWallach%2C+S%3BBell%2C+N+H&rft.aulast=Gates&rft.aufirst=S&rft.date=1986-04-01&rft.volume=1&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-15 N1 - Date created - 1988-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Grief as a Crisis: Psychotherapeutic Interventions with Elderly Bereaved AN - 61621735; 198600600 AB - A description of a psychotherapeutic intervention for handling abnormal or prolonged grief in elderly Ss, derived from B. Raphael's model of crisis intervention (see "Crisis Intervention: Theoretical and Methodological Considerations," Australian-New Zealand Journal of Psychiatry, 1971, 5, 183-190). Two case studies are presented in which the technique was demonstrated to rapidly & efficiently facilitate grief work. The feasibility & usefulness of psychotherapy with the aged is illustrated, contrary to earlier reports that the modality was not an effective treatment for geriatric patients. 24 References. HA JF - American Journal of Psychotherapy AU - Essa, Mohsain AD - Veterans Administration Medical Center, 2002 Holcombe Blvd Houston TX 77211 Y1 - 1986/04// PY - 1986 DA - April 1986 SP - 243 EP - 251 VL - 40 IS - 2 SN - 0002-9564, 0002-9564 KW - bereaved elderly, psychotherapeutic intervention KW - Psychotherapy KW - Elderly KW - Grief KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61621735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Psychotherapy&rft.atitle=Grief+as+a+Crisis%3A+Psychotherapeutic+Interventions+with+Elderly+Bereaved&rft.au=Essa%2C+Mohsain&rft.aulast=Essa&rft.aufirst=Mohsain&rft.date=1986-04-01&rft.volume=40&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Psychotherapy&rft.issn=00029564&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Psychotherapy; Grief ER - TY - JOUR T1 - An Investigation of Power in an Interdisciplinary Health Care Team AN - 61586248; 198800673 AB - A study of how power is perceived & shared in a nonhierarchical, interdisciplinary health care model, based on data collected via interviews & questionnaires completed by 11 members of a geriatrics health care team. Results indicate that team members recognized the existence of power & power sources that were functional in team decision making. There were discrepancies, however, between any one team member's idealization of what makes people powerful, & the reality of power they saw possessed & used by their colleagues. Power is seen as a concept that should be delineated & studied further in regard to the provision of health care. 3 Tables, 17 References. Modified HA JF - Gerontology & Geriatrics Education AU - Drinka, Theresa AU - Ray, Robert O AD - William S. Middleton Memorial Veterans Administration Hospital, 2500 Overlook Terrace Madison WI 53705 Y1 - 1986/04// PY - 1986 DA - April 1986 SP - 43 EP - 53 VL - 6 IS - 3 SN - 0270-1960, 0270-1960 KW - power perception/sharing, nonhierarchical/interdisciplinary health care models KW - interviews, questionnaires KW - members, geriatrics health care team KW - Health Professions KW - Power KW - Teamwork KW - Group Dynamics KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61586248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=An+Investigation+of+Power+in+an+Interdisciplinary+Health+Care+Team&rft.au=Drinka%2C+Theresa%3BRay%2C+Robert+O&rft.aulast=Drinka&rft.aufirst=Theresa&rft.date=1986-04-01&rft.volume=6&rft.issue=3&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Professions; Power; Teamwork; Group Dynamics ER - TY - JOUR T1 - Adolescent Sexual Offenders: Offender and Offense Characteristics AN - 60898482; 88T5106 AB - Descriptive data are presented on 305 adolescent sexual offenders evaluated via interviews & standardized tests as part of the Juvenile Sexual Offender Project at the U of Washington between 1976 & 1981. Types of offenses & the circumstances under which they occurred are detailed. Results suggest that adolescents commit an array of sexual offenses; these offenses are not typically isolated incidents, & are frequently indicative of more general adjustment difficulties. 3 Tables, 19 References. Modified HA JF - American Journal of Orthopsychiatry AU - Fehrenbach, Peter A AU - Smith, Wayne AU - Monastersky, Caren AU - Deisher, Robert W AD - Family Therapy Program (116FTP) Veterans Administration Medical Center, 1660 South Columbian Way Seattle WA 98108 Y1 - 1986/04// PY - 1986 DA - April 1986 SP - 225 EP - 233 VL - 56 IS - 2 SN - 0002-9432, 0002-9432 KW - adolescent sexual offenders, offense/offender characteristics KW - interviews, standardized tests KW - project participants, Washington KW - 1976-1981 KW - Sexual Deviation KW - Adolescents KW - article KW - 1940: the family and socialization; sociology of sexual behavior KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60898482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Adolescent+Sexual+Offenders%3A+Offender+and+Offense+Characteristics&rft.au=Fehrenbach%2C+Peter+A%3BSmith%2C+Wayne%3BMonastersky%2C+Caren%3BDeisher%2C+Robert+W&rft.aulast=Fehrenbach&rft.aufirst=Peter&rft.date=1986-04-01&rft.volume=56&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Adolescents; Sexual Deviation ER - TY - JOUR T1 - Azole antifungal drugs in treatment of coccidioidomycosis. AN - 77336346; 3317599 AB - For two decades amphotericin B has been the only antifungal drug with proven efficacy against Coccidioides immitis. The introduction of miconazole in the late 1970s ushered in a new era of antifungal therapy. Miconazole induced remissions in patients with disease refractory to amphotericin B and in patients who had relapsed after amphotericin B treatment. Almost as important, miconazole did not have the nephrotoxicity associated with amphotericin B. However, the necessity of intravenous administration and other toxicities limited the value of miconazole. The first child of miconazole was ketoconazole, which could be administered orally and had markedly less toxicity than amphotericin B or miconazole. Because coccidioidomycosis challenges any antifungal drug, doses were increased to as much as 2,000 mg/d. Ketoconazole can be used for long terms and at high doses, with many patients brought into remission. However relapses and failures still occurred; dose-related endocrine and gastrointestinal toxicities were uncovered. A third generation of azoles, the triazoles, was introduced to minimize these adverse effects, yet retain the efficacy of ketoconazole. Early clinical trials are promising for itraconazole. Other triazoles with advantageous pharmacokinetic properties are also coming into clinical trials. Shortly, we are likely to have available a whole range of antifungal agents for treatment of this most frustrating disease. JF - Seminars in respiratory infections AU - Graybill, J R AD - Division of Infectious Diseases, Audie Murphy Veterans Administration Hospital, San Antonio, TX 78284. Y1 - 1986/03// PY - 1986 DA - March 1986 SP - 53 EP - 60 VL - 1 IS - 1 SN - 0882-0546, 0882-0546 KW - Antifungal Agents KW - 0 KW - Imidazoles KW - Triazoles KW - Index Medicus KW - Humans KW - Imidazoles -- therapeutic use KW - Triazoles -- therapeutic use KW - Coccidioidomycosis -- drug therapy KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77336346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+infections&rft.atitle=Azole+antifungal+drugs+in+treatment+of+coccidioidomycosis.&rft.au=Graybill%2C+J+R&rft.aulast=Graybill&rft.aufirst=J&rft.date=1986-03-01&rft.volume=1&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+infections&rft.issn=08820546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Social Skills and Irrational Beliefs: A Preliminary Report AN - 60907560; 87R1457 AB - Recent studies have suggested that irrational beliefs, as measured by the Irrational Beliefs Test (IBT), may contribute to social skills deficits. However, studies evaluating the correspondence between irrational beliefs & behavioral indices of social skills & social anxiety have yet to be reported. IBT data obtained from social skill deficit patient populations also have yet to appear in the literature. These issues are addressed by: (1) presenting IBT data obtained from a sample of 63 psychiatric patients referred for assessment of social skills deficits & evaluating the relationship of these data & patients' performance on a standardized behavioral measure of social skills & social anxiety, the Simulated Social Interaction Test (SSIT); & (2) presenting a comparison between IBT subscale scores obtained from the psychiatric sample & those obtained from a large (N = 897) student sample. A weak relationship was found between 2 IBT subscales & the SSIT. Significant mean level differences between patients' performance & student norms were also found on 4 subscales of the IBT: emotional irresponsibility, anxious overconcern, problem avoidance, & helplessness. Implications for further assessment & treatment research with the IBT, & with social anxiety & social skills are discussed. 1 Table, 13 References. Modified HA JF - Journal of Behavior Therapy and Experimental Psychiatry AU - Monti, Peter M AU - Zwick, William R AU - Warzak, William J AD - Veterans Administration Medical Center, Davis Park Providence RI 02908 Y1 - 1986/03// PY - 1986 DA - March 1986 SP - 11 EP - 14 VL - 17 IS - 1 SN - 0005-7916, 0005-7916 KW - social skills deficits KW - irrational beliefs KW - scales KW - psychiatric patients, students KW - Skills KW - Mental Patients KW - Irrationality KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60907560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavior+Therapy+and+Experimental+Psychiatry&rft.atitle=Social+Skills+and+Irrational+Beliefs%3A+A+Preliminary+Report&rft.au=Monti%2C+Peter+M%3BZwick%2C+William+R%3BWarzak%2C+William+J&rft.aulast=Monti&rft.aufirst=Peter&rft.date=1986-03-01&rft.volume=17&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavior+Therapy+and+Experimental+Psychiatry&rft.issn=00057916&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JBTEAB N1 - SubjectsTermNotLitGenreText - Skills; Irrationality; Mental Patients ER - TY - RPRT T1 - VETERANS ADMINISTRATION MEDICAL CENTER, PALM BEACH COUNTY, FLORIDA. AN - 36393903; 675 AB - PURPOSE: Construction of a new Veterans Administration Medical Center (VAMC) in northern Palm Beach County, Florida is proposed to meet the needs of the region's growing veteran population, as well as of existing resident veterans who currently must travel to Miami for inpatient treatment at a VAMC. Plans for the proposed Palm Beach County facility include a 625-bed general medical and surgical hospital plus a 240-bed nursing home on an approximately 60-acre site. The land area required could be as large as 300,000 square feet. The nursing home might be a separate one- or two-story structure (noninterstitial construction) built from existing prototypical plans with an architectural footprint of 44,000 gross square feet (GSF) and a maximum dimension of 430 feet. Additional land uses required would be patient recreation, roads, parking, environmental buffers, and a stormwater retention pond. The hospital and surrounding site would be designed to allow up to a 25-percent expansion of the original hospital. In addition to the hospital and nursing care home, the VAMC will include support facilities such as an energy plant for heating and cooling, maintenance shops and equipment, and warehouse space with truck access. The estimated parking requirement is for 1,200 to 1,500 spaces. The proposed hospital would be a secondary care facility providing primary diagnosis and treatment services, ambulatory surgery, and common and uncomplicated medical, surgical, and psychiatric inpatient treatment. The five alternative sites considered for the VAMC are (1) the Holiday Country Club Site, (2) the Bankers Land Northwest Site, (3) the Riviera Beach Site, (4) the Bankers Land Northeast Site, and (5) the Bankers Land Southwest Site. Total costs are estimated to be $151.5 million. POSITIVE IMPACTS: The social impacts associated with the operation of the proposed VAMC are expected to be positive: improved health care to local veterans and reduced cost and travel time for those visiting family and friends at the VAMC. Employment increases would enhance the county's economic base. State and local tax yields would increase. The proposed Palm Beach County facility would spin off various types and sizes of shoppers goods stores and restaurants. The spin-off retail development is estimated at $14.6 million in sales. NEGATIVE IMPACTS: Several areas would be subject to excessive noise levels during the construction phase. An estimated 6,000 to 6,500 pounds per day of pathological or hazardous wastes would be generated when the VAMC is in operation. Three of the sites contain wetlands, and mitigating measures would be undertaken to minimize any adverse effects. Residential owners whose property may overlook the hospital site might experience a loss of privacy. Major roadway widenings will be required. LEGAL MANDATES: Executive Order 11990, Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.), and Uniform Relocation Assistance and Real Property Acquisition Policies Act of 1970 (42 U.S.C. 4601). JF - EPA number: 860058, 2 volumes and maps, February 14, 1986 PY - 1986 KW - Urban and Social Programs KW - Buildings KW - Cost Assessments KW - Disposal KW - Emissions KW - Employment KW - Hospitals KW - Municipal Services KW - Noise Assessments KW - Parking KW - Recreation KW - Relocations-Property Acquisitions KW - Roads KW - Section 404(b) Statements KW - Site Planning KW - Wastes KW - Wetlands KW - Wildlife KW - Wildlife Habitat KW - Florida KW - Executive Order 11990, Wetlands KW - Federal Water Pollution Control Act of 1972, Section 404 Permits KW - Uniform Relocation Assistance and Real Property Acquisition Policies Act of 1970, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36393903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-02-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+PALM+BEACH+COUNTY%2C+FLORIDA.&rft.title=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+PALM+BEACH+COUNTY%2C+FLORIDA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Veterans Administration, Office of Construction, Washington, D.C.; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: February 14, 1986 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Morphometric Change in Laryngeal Cartilages of Males (20-50 Years) AN - 85512740; 9004716 AB - Although it is generally agreed that voice production is affected by the aging process, a void exists regarding structural changes that might account for the observed vocal changes. An attempt is made to provide additional normative information about morphologic characteristics of the male larynx & to investigate whether morphometric changes in male laryngeal cartilages occur between the ages of 20 & 50. Results show that change in the morphology of the male larynx does not occur at this age & that changes in the hard tissue do not contribute significantly to vocal aging, but that changes are more likely related to changes in soft tissue, an area currently under investigation. 5 Figures, 4 References. A. Sturrock JF - The IASCP Bulletin AU - Ochipa, Cindy AU - Hicks, Douglas M AD - Veterans Administration Medical Center, Gainesville FL 32602 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 19 EP - 27 VL - 2 KW - male laryngeal cartilages, morphometric change/aging process KW - Phonation Structures (ph5) KW - Laryngology (la12) KW - Oral Structures (or2) KW - Biological, Physical, Physiological (bi3) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85512740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+IASCP+Bulletin&rft.atitle=Morphometric+Change+in+Laryngeal+Cartilages+of+Males+%2820-50+Years%29&rft.au=Ochipa%2C+Cindy%3BHicks%2C+Douglas+M&rft.aulast=Ochipa&rft.aufirst=Cindy&rft.date=1986-01-01&rft.volume=2&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=The+IASCP+Bulletin&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - IBULDT N1 - SubjectsTermNotLitGenreText - Phonation Structures (ph5); Biological, Physical, Physiological (bi3); Oral Structures (or2); Laryngology (la12) ER - TY - JOUR T1 - Alcohol use and psychopathology in opioid addicts on methadone maintenance. AN - 77360677; 3503569 AB - The occurrence of alcohol problems in opiate addicts on methadone maintenance presents a serious challenge for treatment. Dually addicted patients have a higher incidence of medical and psychiatric complications, consume large amounts of staff and treatment resources, and often exit treatment through administrative detoxification. Yet, little is known about differences in psychopathology between this group and other opioid addicts. This paper summarizes data for 166 male opioid addicts receiving methadone treatment. Alcohol problems were identified, and the relationship between dual addiction and psychopathology was explored. In the first phase of the study the MMPI and Brief MAST (Michigan Alcoholism Screening Test) were administered to 91 subjects. Comparison of Brief MAST scores with program counselors' judgments of the presence or absence of an alcohol problem showed a significant relationship. Cluster analysis of MMPI scores generated three groups. The clusters had significantly different mean MAST scores with the normal cluster having the least indication of alcohol problems, the neurotic cluster intermediate, and the schizoid cluster the greatest indication of problematic alcohol consumption. The second phase of the study with another 75 subjects replicated the relationship between cluster membership and MAST score. The Addiction Severity Index (ASI) was also administered to these subjects, and high correlations between Brief MAST and ASI alcohol problem measures were found. Within-treatment outcome data on a number of measures were then collected for 1 year. Problem drinking severity was negatively related to employment status and positively related to number of random urinalyses indicating illicit drug use. Implication of these findings for refining treatment strategies are discussed. JF - The American journal of drug and alcohol abuse AU - Roszell, D K AU - Calsyn, D A AU - Chaney, E F AD - Veterans Administration Medical Center, Seattle, Washington 98101. Y1 - 1986 PY - 1986 DA - 1986 SP - 269 EP - 278 VL - 12 IS - 3 SN - 0095-2990, 0095-2990 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Unemployment KW - Personality Tests KW - Humans KW - Adult KW - Social Support KW - Marriage KW - Male KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Opioid-Related Disorders -- complications KW - Alcoholism -- diagnosis KW - Opioid-Related Disorders -- rehabilitation KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77360677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Alcohol+use+and+psychopathology+in+opioid+addicts+on+methadone+maintenance.&rft.au=Roszell%2C+D+K%3BCalsyn%2C+D+A%3BChaney%2C+E+F&rft.aulast=Roszell&rft.aufirst=D&rft.date=1986-01-01&rft.volume=12&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differences between alcoholic couples accepting and rejecting an offer of outpatient marital therapy. AN - 77359028; 3503571 AB - Following an extensive initial evaluation, 35 couples with alcoholic husbands decided to participate in couples therapy (acceptors) and 28 couples did not (rejectors). A significant discriminant function indicated that acceptors were characterized by husbands with more education, better marital adjustment, full-time employment, and larger number of alcohol-related arrests. Acceptors also had sought more outpatient help in the past year. Rejectors were characterized by wives with better marital adjustment, greater living distance from clinic, and husbands with more alcohol-related hospitalizations. Rejector husbands also tended to be older. Practical implications for recruiting alcoholics and spouses into marital therapy are discussed. JF - The American journal of drug and alcohol abuse AU - O'Farrell, T J AU - Kleinke, C L AU - Thompson, D L AD - Veterans Administration Medical Center, Brockton, Massachusetts 02401. Y1 - 1986 PY - 1986 DA - 1986 SP - 285 EP - 294 VL - 12 IS - 3 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - Educational Status KW - Age Factors KW - Humans KW - Marriage KW - Employment KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Marital Therapy KW - Patient Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77359028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Differences+between+alcoholic+couples+accepting+and+rejecting+an+offer+of+outpatient+marital+therapy.&rft.au=O%27Farrell%2C+T+J%3BKleinke%2C+C+L%3BThompson%2C+D+L&rft.aulast=O%27Farrell&rft.aufirst=T&rft.date=1986-01-01&rft.volume=12&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The personality structure of heroin addicts. AN - 77328324; 3122051 JF - NIDA research monograph AU - Craig, R J AD - Drug Abuse Program, West Side Veterans Administration, Medical Center, Chicago, IL 60612. Y1 - 1986 PY - 1986 DA - 1986 SP - 25 EP - 36 VL - 74 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Internal-External Control KW - Humans KW - Personality Assessment KW - Ego KW - Psychological Tests KW - Personality KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77328324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+personality+structure+of+heroin+addicts.&rft.au=Craig%2C+R+J&rft.aulast=Craig&rft.aufirst=R&rft.date=1986-01-01&rft.volume=74&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments AN - 754879324; 13379864 AB - Both murine and heterotransplanted human nonseminomatous germ-cell tumors have been successfully located by external scintigraphy using radioiodinated anti-SSEA-1, a monoclonal IgM, and its pepsin-derived antigen-binding fragment, F(ab)2. Antibody localization in the tumor is mainly due to antigenic specificity, rather than to nonspecific trapping, and depends strongly on the amount of time after injection. The antibody has been used for drug targeting in vitro and in vivo. JF - Journal of Surgical Oncology AU - Ballou, Byron AU - Reiland, Jean M AU - Levine, Geoffrey AU - Taylor, Rodney J AU - Shen, Wei-Chiang AU - Ryser, Hughes J-P AU - Solter, Davor AU - Hakala, Thomas R AD - Division of Urological Surgery, Department of Surgery, the Department of Radiology, School of Medicine, Department of Pharmaceutics, School of Pharmacy, University of Pittsburgh, Veterans Administration Hospital, Department of Nuclear Medicine, Presbyterian-University Hospital, Pittsburgh, Wistar Institute, Philadelphia, Pennsylvania Y1 - 1986/01// PY - 1986 DA - Jan 1986 SP - 1 EP - 12 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 31 IS - 1 SN - 0022-4790, 0022-4790 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Monoclonal antibodies KW - Tumors KW - Fab KW - Scintigraphy KW - Trapping KW - Immunoglobulin M KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754879324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Tumor+location+and+drug+targeting+using+a+monoclonal+antibody+%28anti-SSEA-1%29+and+antigen-binding+fragments&rft.au=Ballou%2C+Byron%3BReiland%2C+Jean+M%3BLevine%2C+Geoffrey%3BTaylor%2C+Rodney+J%3BShen%2C+Wei-Chiang%3BRyser%2C+Hughes+J-P%3BSolter%2C+Davor%3BHakala%2C+Thomas+R&rft.aulast=Ballou&rft.aufirst=Byron&rft.date=1986-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930310102 L2 - http://www3.interscience.wiley.com/journal/112719681/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug delivery; Monoclonal antibodies; Tumors; Fab; Trapping; Scintigraphy; Immunoglobulin M DO - http://dx.doi.org/10.1002/jso.2930310102 ER - TY - JOUR T1 - Life after Death: Vietnam Veteran's Struggle for Meaning and Recovery AN - 61590091; 198601640 AB - Of the 3.7 million men & women who served in Vietnam, approximately 20% to 25% still live in the shadows of death through painful intrusive recollections of the war. For some, turning to violence, drugs, alcohol, self-destructiveness, anhedonia, & depression are consequences of the indelible imprint of Vietnam's death imagery on their minds. The relatively high rate of divorce, psychological symptomatology, suicide, drug & alcohol abuse, arrests, & work-related problems attest to the lack of resolution of conflicts related to serving in Vietnam. It is argued that much of these symptoms stem from an unconscious death obsession. These problems represent death equivalents, which manifest themselves pervasively in the lives of these veterans. A pervasive readjustment problem cuts across all diagnostic categories with Vietnam veterans, termed "posttraumatic death syndrome." The syndrome & its components are analyzed in their relationship to major symptoms of posttraumatic stress disorder. The need for these veterans to develop a coherent meaning system is also discussed. 31 References. HA JF - Death Studies AU - Parson, Erwin Randolph AD - Veterans Administration Medical Center, Northport NY 11768 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 11 EP - 26 VL - 10 IS - 1 SN - 0748-1187, 0748-1187 KW - readjustment problems, posttraumatic death syndrome, Vietnam veterans KW - Psychological Stress KW - Veterans KW - Death Attitudes KW - Vietnam War KW - Mental Illness KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61590091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Death+Studies&rft.atitle=Life+after+Death%3A+Vietnam+Veteran%27s+Struggle+for+Meaning+and+Recovery&rft.au=Parson%2C+Erwin+Randolph&rft.aulast=Parson&rft.aufirst=Erwin&rft.date=1986-01-01&rft.volume=10&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Death+Studies&rft.issn=07481187&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Psychological Stress; Death Attitudes; Mental Illness ER - TY - JOUR T1 - The Development of Health and Social Services for the Elderly in Iceland: An Overview AN - 61572576; 198802581 AB - A historical overview of health & social services for the aged in Iceland. After a long history of subsistence, Icelandic society began to develop, but much later than other Western nations. The 1,000-year preindustrial period was in large part a struggle for survival, in which formal & informal measures to support the infirm were often overwhelmed by disease & famine. The speed & propinquity of Iceland's transition from these conditions has resulted in rapid development of occupational rules & other SS shifts, vast health status improvements, & great population & Ur growth. The effect of these trends on the situation of the elderly is described, & current organization of health & social services is reviewed. 6 Tables, 3 Figures, 64 References. Modified HA JF - Social Science and Medicine AU - Wieland, G Darryl AU - Palsdottir, Dogg AD - Education & Clinical Center Sepulveda Veterans Administration Medical Center, CA 91343 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 1333 EP - 1345 VL - 23 IS - 12 SN - 0277-9536, 0277-9536 KW - aged, health/social services, Iceland KW - Health Care KW - Health Services KW - Ireland KW - Elderly KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61572576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=The+Development+of+Health+and+Social+Services+for+the+Elderly+in+Iceland%3A+An+Overview&rft.au=Wieland%2C+G+Darryl%3BPalsdottir%2C+Dogg&rft.aulast=Wieland&rft.aufirst=G&rft.date=1986-01-01&rft.volume=23&rft.issue=12&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elderly; Health Services; Health Care; Ireland ER - TY - JOUR T1 - Efficacy of Chemical Dependency Treatment as a Function of Combat in Vietnam AN - 61557468; 198701208 AB - Traumatized combat veterans frequently attempt to escape the chronic anxiety, insomnia, & nightmares characteristic of post-traumatic stress disorder by self-medicating with alcohol & drugs. The elimination of alcohol & drugs through chemical-dependency treatment, therefore, might be expected to precipitate an exacerbation of stress symptoms & predispose veterans to new cycles of abuse. Treatment completion & posttreatment abstinence rates (treatment efficacy) are examined as a function of level of combat when combat veterans are provided trauma-oriented therapy concurrently with treatment for chemical dependency, using data on non-, light-, & heavy-combat Vietnam veterans (N = 22, 19, & 19, respectively) treated in a Veterans Administration Medical Center chemical dependency program. The experimental results suggest that, under these conditions, treatment efficacy does not vary with level of combat. The absence of combat-level effects is explained in terms of the interactive dynamics of chemical-dependency & post-traumatic stress disorder. 1 Table, 21 References. Modified HA JF - Journal of Substance Abuse Treatment AU - Kuhne, Arthur AU - Nohner, William AU - Baraga, Elizabeth AD - Veterans Administration Medical Center, Saint Cloud MN 56301 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 191 EP - 194 VL - 3 IS - 3 SN - 0740-5472, 0740-5472 KW - chemically dependent traumatized combat veterans, chemical dependency vs trauma-oriented therapy KW - case records KW - Vietnam veterans KW - Veterans KW - Psychological Stress KW - Substance Abuse KW - Psychotherapy KW - Vietnam War KW - Treatment Compliance KW - Combat KW - Recidivism KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61557468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Efficacy+of+Chemical+Dependency+Treatment+as+a+Function+of+Combat+in+Vietnam&rft.au=Kuhne%2C+Arthur%3BNohner%2C+William%3BBaraga%2C+Elizabeth&rft.aulast=Kuhne&rft.aufirst=Arthur&rft.date=1986-01-01&rft.volume=3&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychological Stress; Combat; Veterans; Substance Abuse; Vietnam War; Treatment Compliance; Recidivism; Psychotherapy ER - TY - JOUR T1 - The Scientific Status of Psychoanalysis: Lacan contra Freud AN - 60980638; 88T4981 AB - Jacques Lacan's view of psychoanalysis has passed through two stages -- an earlier one in which he regarded it as scientific, & a later one in which he regarded it as unscientific but as a valuable praxis. Lacan maintains that the subject matter of psychoanalysis is the Freudian unconscious, which, not being an object but a structure, cannot be the object of a science in the traditional sense; rather, psychoanalysis is a theory that organizes experiences & that cannot & need not be tested. The desire for truth, in his view, is the key characteristic of science; in psychoanalysis, the psychoanalyst's desire for truth as manifested in the psychoanalytic situation is crucial. Lacan sees the Oedipal situation as reflected in the resulting psychoanalytic situation; at the same time, Lacan's own interpretation of Freud establishes a relation between the two that also shares in this structure. Ultimately, this leads to an impasse in which psychoanalysis cannot be established as scientific, but rather is a practical rhetoric whose ultimate significance is ethical. 45 References. W. H. Stoddard JF - Psychoanalysis and Contemporary Thought AU - Laor, Nathaniel AU - Agassi, Joseph AD - Medical Center Veterans Administration, West Spring St West Haven CT 06516 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 465 EP - 492 VL - 9 IS - 3 SN - 0161-5289, 0161-5289 KW - psychoanalysis, Jacques Lacan's thought KW - Psychoanalysis KW - Lacan, Jacques KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60980638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoanalysis+and+Contemporary+Thought&rft.atitle=The+Scientific+Status+of+Psychoanalysis%3A+Lacan+contra+Freud&rft.au=Laor%2C+Nathaniel%3BAgassi%2C+Joseph&rft.aulast=Laor&rft.aufirst=Nathaniel&rft.date=1986-01-01&rft.volume=9&rft.issue=3&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Psychoanalysis+and+Contemporary+Thought&rft.issn=01615289&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PCTHDS N1 - SubjectsTermNotLitGenreText - Psychoanalysis; Lacan, Jacques ER - TY - JOUR T1 - Exercise-related knee joint laxity AN - 20753152; 10092865 AB - Knee injuries are the topic of increasingly sophisticated research because of the importance in professional athletics as well as increasing participation in recrea tional sports. The role of conditioning and fatigue in these injuries remains controversial. Ligaments have high collagen content, and a viscoelastic response to stress would be expected. Because of the postulated relationship between laxity and knee ligament injuries, an experiment was designed using highly motivated athletes to test the hypothesis that exercise to the point of muscular fatigue may cause laxity of the knee and thereby place athletes at risk for ligamentous injury to the knee when fatigued.An exercise protocol was designed to produce mus cle fatigue in the hamstring and quadriceps muscle groups. Knee ligament laxity was tested prior to and subsequent to the exercise protocol. To document muscle fatigue, isokinetic testing of right knee flexion and extension power was used several times during the exercise protocol. A knee arthrometer (KT-1000) was used to quantitatively document ligamentous laxity before and after exercise. The results indicated a sig nificant lengthening in knee joint laxity between preex ercise and postexercise in the left knee as measured at 15 and 20 pounds of passive displacement force ( P < 0.05). Maximum manual displacement also demon strated a significant increase in joint laxity (P = 0.02). The right knee, which had undergone isokinetic testing, demonstrated a similar tendency but without a statisti cally significant difference before and after exercise. There was no significant preexercise side to side differ ence, but postexercise measurements demonstrated a left-right difference at 15 pounds, 20 pounds, and max imum manual displacement of statistical significance (P < 0.01).These previously unreported findings document an in vivo increase in the anterior laxity of the knee joint due to exercise. The clinical implications to be drawn from this study are that more accurate clinical examination of the knee may be obtained after a short cool-down period in the knee with suspected ligamentous injury, and, in addition, athletes should be encouraged to perform vigorous warm-up exercises when entering organized sports activities after cool-down periods of greater than 15 minutes. JF - American Journal of Sports Medicine AU - Skinner, H B AU - Wyatt, M P AU - Stone, M L AU - Hodgdon, JA AU - Barrack, R L AD - Department of Orthopaedic Surgery, University of California, San Francisco, and Rehabilitation Research and Development, Veterans Administration, San Francisco, California Y1 - 1986/01// PY - 1986 DA - Jan 1986 SP - 30 EP - 34 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 14 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Health & Safety Science Abstracts KW - Ligaments KW - Fatigue KW - Injuries KW - Muscles KW - Knees KW - Stress KW - Motor performance tests KW - Exercise KW - Muscles (fatigue) KW - fatigue KW - sports related injuries KW - athletes KW - Joint stability KW - Mus KW - Athletes KW - H 11000:Diseases/Injuries/Trauma KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Exercise-related+knee+joint+laxity&rft.au=Skinner%2C+H+B%3BWyatt%2C+M+P%3BStone%2C+M+L%3BHodgdon%2C+JA%3BBarrack%2C+R+L&rft.aulast=Skinner&rft.aufirst=H&rft.date=1986-01-01&rft.volume=14&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658601400106 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ligaments; Fatigue; Injuries; Joint stability; Knees; Motor performance tests; Muscles (fatigue); Exercise; Athletes; sports related injuries; athletes; Muscles; Stress; fatigue; Mus DO - http://dx.doi.org/10.1177/036354658601400106 ER - TY - JOUR T1 - Electroelution for purification of influenza A matrix protein for use in immunoassay. AN - 14404054; 1315589 AB - A new preparative method for isolation of matrix protein from type A influenza virus was developed. Commercially available whole virus or split virus vaccines were lysed, and the soluble proteins separated by electrophoresis on polyacrylamide gel. The matrix protein was located on the gel by precipitation with KCl, and recovered by electroelution. The method was technically simple and required little direct supervision during the two-step recovery process. Yields of A matrix were consistently high, averaging 68.1% in five trials with A/Brazil/X-71. The method was also successful with other A viruses, although not with influenza B virus. Isolated A matrix had less than 0.5% contamination by hemagglutinin or nucleoprotein, as determined by immunoblotting and ELISA. JF - Journal of Virological Methods AU - Donofrio, J C AU - Coonrod, J D AU - Karathanasis, V AU - Coelingh, KVW AD - Infect. Dis. Serv., Veterans Administration Med. Cent., Lexington, KY 40511, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 107 EP - 120 VL - 13 IS - 2 SN - 0166-0934, 0166-0934 KW - electrophoresis KW - elution KW - enzyme-linked immunosorbent assay KW - hybridization analysis KW - influenza A virus KW - matrix KW - proteins KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - F 06723:Other labelling methods KW - A 01114:Viruses KW - V 22091:Immunological techniques & reagents KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14404054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Electroelution+for+purification+of+influenza+A+matrix+protein+for+use+in+immunoassay.&rft.au=Donofrio%2C+J+C%3BCoonrod%2C+J+D%3BKarathanasis%2C+V%3BCoelingh%2C+KVW&rft.aulast=Donofrio&rft.aufirst=J&rft.date=1986-01-01&rft.volume=13&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - hybridization analysis; electrophoresis; proteins; enzyme-linked immunosorbent assay ER - TY - JOUR T1 - Methods for isolating Campylobacter jejuni from low turbidity water AN - 13823614; 198603390 AB - These experiments evaluated membrane filtration methods for the quantitative recovery of C. jejuni from seeded sterile distilled water and seeded natural source water of low turbidity. Best results were obtained by filtration through a 0.45 um pore filter, placing the filter facedown on a plate of Campylobacter-sensitive agar for overnight incubation, streaking the plate for isolation, and incubating for a further 24-48 h. Recovery from natural waters was improved by prefiltration through 5.0 and 0.6 um pore membranes. In the presence of standard plate count organisms (75000 CFU per 250 ml), seeds with a mean of 30 C. jejuni CFU per 250 ml were consistently detected in natural waters. Methods involving plating of the 0.45 um pore filter faceup, or preincubation of the filter in an enrichment broth were less sensitive. JF - Applied and Environmental Microbiology AU - Blaser, MJ AU - Cody, HJ AD - Veterans Administration Medical Center, Denver, Colo. Y1 - 1986 PY - 1986 DA - 1986 SP - 312 EP - 315 VL - 51 IS - 2 SN - 0099-2240, 0099-2240 KW - Filters (see also packed columns, groups below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13823614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Methods+for+isolating+Campylobacter+jejuni+from+low+turbidity+water&rft.au=Blaser%2C+MJ%3BCody%2C+HJ&rft.aulast=Blaser&rft.aufirst=MJ&rft.date=1986-01-01&rft.volume=51&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Inactivation of Campylobacter jejuni by chlorine and monochloramine AN - 13817142; 198603446 AB - Inactivation of 3 C. jejuni serotypes (PEN 1, PEN 2, PEN 3 type strains) and Escherichia coli ATCC 11229 by chlorine (0.1 mg per litre) or monochloramine (1.0 mg per litre) was studied at pH 6 and 8, and at 4 and 25C. Results showed 99 per cent inactivation of C. jejuni after 5 minutes contact with chlorine or 15 minutes contact with monochloramine under all experimental conditions. Inactivation was more rapid at pH 6 than at pH 8. Monochloramine disinfection was more rapid at 25C than at 4C. Experiments involving the use of an antibiotic containing medium suggested that a sizeable proportion of those cells remaining after chlorine disinfection were injured, especially at pH 6. Laboratory passaged C. jejuni strains were just as susceptible to disinfection as were those passaged through mice. In all experiments, C. jejuni was equally susceptible or more susceptible than E. coli to inactivation. The contact times used in these studies were shorter and halogen concentrations lower than the standards recommended for water treatment, and C. jejuni concentrations greatly exceeded those likely to be found even in grossly contaminated waters. It was thus concluded that drinking water disinfection procedures which removed coliform bacteria were adequate for C. jejuni removal. JF - Applied and Environmental Microbiology AU - Blaser, MJ AU - Smith, P F AU - Wang, W L AU - Hoff, J C AD - Veterans Administration Medical Center, Denver, Colo. Y1 - 1986 PY - 1986 DA - 1986 SP - 307 EP - 311 VL - 51 IS - 2 SN - 0099-2240, 0099-2240 KW - Media KW - Aqualine Abstracts KW - AQ:00000 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13817142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Inactivation+of+Campylobacter+jejuni+by+chlorine+and+monochloramine&rft.au=Blaser%2C+MJ%3BSmith%2C+P+F%3BWang%2C+W+L%3BHoff%2C+J+C&rft.aulast=Blaser&rft.aufirst=MJ&rft.date=1986-01-01&rft.volume=51&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Detoxification Recidivism among Urban American Indian Alcoholics AN - 60976193; 87T0696 AB - Fifty Ur American Indians were interviewed during admission to a free-standing medical detoxification unit. From the year before the interview through 2 years of follow-up interviews, this sample averaged 44.6 detoxification admissions & 64.1 days in other inpatient treatment & had no significant change in the number of annual detoxification admissions. At follow-up, all but 3 Ss reported recent alcohol dependence symptoms or episodic alcohol abuse. These patients continued to experience serious alcohol-related problems despite repeated treatment in both medical detoxification & inpatient rehabilitation settings. The findings emphasize the need for more innovative & effective alternatives to the existing revolving door process. 2 Tables, 15 References. HA JF - The American Journal of Psychiatry AU - Kivlahan, Daniel R AU - Walker, R Dale AU - Donovan, Dennis M AU - Mischke, Harold D AD - Veterans Administration Medical Center, 1660 Columbian Way South Seattle WA 98108 Y1 - 1985/12// PY - 1985 DA - December 1985 SP - 1467 EP - 1470 VL - 142 IS - 12 SN - 0002-953X, 0002-953X KW - alcoholism treatment, urban American Indians, recidivism KW - longitudinal interview study KW - detoxification unit patients KW - Detoxification KW - Rehabilitation KW - Alcoholism KW - United States of America KW - Recidivism KW - American Indians KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60976193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Detoxification+Recidivism+among+Urban+American+Indian+Alcoholics&rft.au=Kivlahan%2C+Daniel+R%3BWalker%2C+R+Dale%3BDonovan%2C+Dennis+M%3BMischke%2C+Harold+D&rft.aulast=Kivlahan&rft.aufirst=Daniel&rft.date=1985-12-01&rft.volume=142&rft.issue=12&rft.spage=1467&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - United States of America; American Indians; Alcoholism; Detoxification; Rehabilitation; Recidivism ER - TY - JOUR T1 - Nutrition of the anterior cruciate ligament. Effects of continuous passive motion AN - 20073153; 10092856 AB - Twelve freshly killed mature male rabbits were used to study the effects of continuous passive motion (CPM) on regional and overall nonvascular nutritional path ways of the anterior cruciate ligament (ACL). One hundred fifty microcuries of super(35)sulphate was injected intraarticularly into each knee joint. The right knee underwent CPM for 1 hour, while the left knee remained immobilized. Both knee joints were then isolated and immediately frozen. The ACLs were removed while still mostly frozen, and sectioned into anterior, middle, and posterior thirds for the six rabbits in Group 1, and proximal, middle, and distal thirds for the six rabbits in Group 2. In addition, quadriceps tendon samples were harvested from each limb of three rabbits. After appro priate processing, all samples were counted in a scin tillation counter, and counts per minute per milligram of tissue were calculated. There was significantly higher uptake in rest extremity ACLs compared to CPM ex tremity ACLs (P = 0.0001 ). No significant difference was demonstrated in regional uptake comparing re spective thirds of the ACL in either Group 1 or Group 2. Quadriceps tendon uptake trended higher in the limbs exposed to CPM compared to those maintained at rest (P = 0.14). The ACL uses diffusion as a primary nutrient pathway. CPM does not increase nutrient up take by the ACL in this avascular model, but CPM may facilitate transport of metabolites out of the joint. No regional differences in uptake within the ACL occurred in either group. JF - American Journal of Sports Medicine AU - Skyhar, Michael J AU - Danzig, Larry A AU - Hargens, Alan R AU - Akeson, Wayne H AD - Division of Orthopaedics and Rehabilitation, Veterans Administration Medical Center, and University of California, San Diego, California Y1 - 1985/12// PY - 1985 DA - Dec 1985 SP - 415 EP - 418 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 6 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Ligaments KW - Animal subjects KW - Knees KW - Rest KW - Sports medicine KW - Nutrition KW - Tendons KW - Metabolism KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Nutrition+of+the+anterior+cruciate+ligament.+Effects+of+continuous+passive+motion&rft.au=Skyhar%2C+Michael+J%3BDanzig%2C+Larry+A%3BHargens%2C+Alan+R%3BAkeson%2C+Wayne+H&rft.aulast=Skyhar&rft.aufirst=Michael&rft.date=1985-12-01&rft.volume=13&rft.issue=6&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658501300609 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Ligaments; Animal subjects; Rest; Knees; Sports medicine; Nutrition; Metabolism; Tendons; Joints DO - http://dx.doi.org/10.1177/036354658501300609 ER - TY - JOUR T1 - Administrative Issues & Current Mental Health Research AN - 61023707; 86Q7048 AB - During the last decade there has been a shift in the focus of mental health research & an increased number of publications in professional journals describing research efforts. There is also an increase in the proportion of investigations devoted to biological factors & into the etiology of psychiatric disorders & a decreased emphasis on psychobehavioral research & research concerning management of psychiatric disorders. The sophistication of mental health research in general has significantly increased. These changes have important & encouraging implications for administrations of mental health programs. 26 References. HA JF - Administration in Mental Health AU - Keill, Stuart L AD - Veterans Administration Medical Center, 3495 Bailey Ave Buffalo NY 14215 Y1 - 1985/10// PY - 1985 DA - October 1985 SP - 15 EP - 21 VL - 13 IS - 1 KW - mental health research, focus/status, administrative implications KW - Mental Health KW - Research KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61023707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Mental+Health&rft.atitle=Administrative+Issues+%26amp%3B+Current+Mental+Health+Research&rft.au=Keill%2C+Stuart+L&rft.aulast=Keill&rft.aufirst=Stuart&rft.date=1985-10-01&rft.volume=13&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Administration+in+Mental+Health&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADMHA2 N1 - SubjectsTermNotLitGenreText - Mental Health; Research ER - TY - RPRT T1 - VETERANS ADMINISTRATION MEDICAL CENTER, ALLEN PARK, MICHIGAN (DRAFT SUPPLEMENT TO THE DRAFT ENVIRONMENTAL IMPACT STATEMENT). AN - 36393946; 487 AB - PURPOSE: Modernization or replacement of the existing Veterans Administration Medical Center (VAMC) at Allen Park, Michigan is proposed. Project alternatives include the following: major renovation; reuse with minor new construction at the VAMC Allen Park; major new construction with some renovation at VAMC Allen Park; a phased replacement hospital on the VAMC Allen Park campus; a total replacement hospital on a site adjacent to the Detroit Medical Center; and a 'no action' alternative. This supplement to the draft EIS, also considers a split facility alternative with ambulatory, medical, and surgical care at Detroit; nursing home and long-term psychiatric care facilities at Allen Park; and an enlarged VAMC at Allen Park, including a replacement hospital plus 120 new long-term psychiatric care beds and 180 nursing home care beds. Depending on the alternative chosen, facilities would be upgraded or constructed to provide ambulatory care, diagnosis and treatment, nursing home care, and logistics departments. Construction phases would range from 5-1/2 to 11 years. POSITIVE IMPACTS: The phased replacement alternative would minimize the magnitude of the noise impact, as there would be less renovation and demolition occurring in the vicinity of hospital occupants. Constructing a replacement VAMC adjacent to the Detroit Medical School could result in a savings of 35,000 hours of physician and medical practitioner time and 14,000 hours of research, intern, and VA staff time now spent in commuting between the medical centers. Relocation could also save more than 40,000 hours of patient travel time per year. In addition, relocation to the Detroit site could enhance the prestige of the entire medical and educational center and accelerate the revitalization of several local districts. Since the VAMC is a designated historic structure, the relocation alternative would guarantee that no changes occurred on the Allen Park site. NEGATIVE IMPACTS: Relocation of the VAMC to Detroit would result in the relocation of approximately 450 residents, garages, and some commercial space. It also would significantly increase traffic flows along the streets bordering the facility. Local businesses could lose approximately $1.0 million per year in gross sales, and approximately 15 employees might lose their jobs if the VAMC was relocated outside of Allen Park. LEGAL MANDATES: National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft environmental impact statement, see 84-0447D, Volume 8, Number 9. JF - EPA number: 850415, 2 volumes, September 26, 1985 PY - 1985 KW - Urban and Social Programs KW - Air Quality KW - Employment KW - Historic Sites KW - Hospitals KW - Landfills KW - Relocations-Property Acquisitions KW - Traffic Control KW - Urban Renewal KW - Michigan KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36393946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-09-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+ALLEN+PARK%2C+MICHIGAN+%28DRAFT+SUPPLEMENT+TO+THE+DRAFT+ENVIRONMENTAL+IMPACT+STATEMENT%29.&rft.title=VETERANS+ADMINISTRATION+MEDICAL+CENTER%2C+ALLEN+PARK%2C+MICHIGAN+%28DRAFT+SUPPLEMENT+TO+THE+DRAFT+ENVIRONMENTAL+IMPACT+STATEMENT%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Veterans Administration, Office of Construction, Washington, D.C.; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: September 26, 1985 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Period Effects on Planned Age for Retirement, 1975-1984: Findings from the Normative Aging Study AN - 61065033; 86Q8887 AB - Temporal changes in the aggregate distribution of workers' planned ages for retirement can indicate broad shifts in workers' regard of retirement that anticipate future retirement practices. A comparison is made of distributions of planned retirement ages across 4 measurement times between 1975 & 1984 for groups of approximately 1,000 men aged 47-64 at each survey. Results show 2 temporal patterns: (1) plans were altered somewhat toward late ages between 1975 & 1978, although this upward distribution of planned ages did not alter the overall proportion of Rs planning to retire prior to age 65; & (2) distributions were stable from 1978 to 1981 to 1984. 3 Tables, 22 References. HA JF - Research on Aging AU - Ekerdt, David J AU - Bosse, Raymond AU - Glynn, Robert J AD - Veterans Administration Outpatient Clinic, Boston MA 02205 Y1 - 1985/09// PY - 1985 DA - September 1985 SP - 395 EP - 407 VL - 7 IS - 3 SN - 0164-0275, 0164-0275 KW - workers' planned retirement age, aggregate distribution, temporal changes KW - surveys KW - 1975-1984 KW - Worker Attitudes KW - Retirement KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61065033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+on+Aging&rft.atitle=Period+Effects+on+Planned+Age+for+Retirement%2C+1975-1984%3A+Findings+from+the+Normative+Aging+Study&rft.au=Ekerdt%2C+David+J%3BBosse%2C+Raymond%3BGlynn%2C+Robert+J&rft.aulast=Ekerdt&rft.aufirst=David&rft.date=1985-09-01&rft.volume=7&rft.issue=3&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Research+on+Aging&rft.issn=01640275&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - REAGDY N1 - SubjectsTermNotLitGenreText - Worker Attitudes; Retirement ER - TY - JOUR T1 - From Conflict to Collaboration: Psychiatry and the Hospital Police AN - 60964097; 87R8549 AB - Many Ur hospitals have institutional police forces that are charged with the responsibility of managing deviant behavior, both that arising from the psychopathology of the patients & from the intrusion of criminal influences from the community. Areas of shared responsibility between these police forces & hospital psychiatrists are explored, with emphasis on conflicts that arise when law enforcement & clinical methods of social control overlap. Tension, distrust, & overt antagonism often erupt in: (1) control of violent behavior; (2) pursuit & retrieval of dangerous patients; (3) enforcement of hospital regulations; (4) consultation on possible law enforcement responses to deviant behavior; & (5) performance of liaison functions between clinicians, community police, & the courts. A lateral liaison structure is proposed to alleviate such problems, & its success in a Veterans Administration Medical Center is described. 18 References. Modified HA JF - Psychiatry AU - Rosenheck, Robert AD - Psychiatry Service 116A Veterans Administration Medical Center, West Haven CT 05616 Y1 - 1985/08// PY - 1985 DA - August 1985 SP - 254 EP - 263 VL - 48 IS - 3 SN - 0033-2747, 0033-2747 KW - deviant behavior control, urban hospitals, institutional police forces vs hospital psychiatrists KW - case study KW - Veterans Administration Medical Center KW - Law Enforcement KW - Urban Areas KW - Police KW - Deviant Behavior KW - Social Control KW - Hospitals KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60964097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=From+Conflict+to+Collaboration%3A+Psychiatry+and+the+Hospital+Police&rft.au=Rosenheck%2C+Robert&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=1985-08-01&rft.volume=48&rft.issue=3&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Urban Areas; Hospitals; Police; Law Enforcement; Deviant Behavior; Social Control ER - TY - JOUR T1 - Available Technology for the Monitoring of Underground Storage Tanks AN - 19018914; 8702449 AB - Some industry experts estimate that of 1.4 million underground storage tanks containing gasoline, 100,000 may be leaking into the nation 's groundwater, the present or potential source of drinking water in many areas. With growing public pressure on government to take action on this subject, one third of the states and over one hundred counties and municipalities have instituted regulatory measures of one sort or another on their books. Many of these regulations specify that some sort of leak detection device be used as the first line of defense against extensive soil and groundwater contamination due to leaks. As little as two years ago, there were less than five manufacturers producing leak devices. Today, there are fifty different devices , which fall into six groups including: thermal conductivity sensors, resistivity sensors, product soluble devices, grab sampling, refractive index sensors and product permeable sensors. It is therefore important, when evaluating detection devices, to consider efficiency, durability and cost, as well as the regulatory requirements of your region. A well thought-out choice in a leak detector will save money by alerting the owner/operator to product loss due to leaks. But most importantly, the correct detector will help limit the substantial financial liability that could be imposed as the result of environmental damage from a leaking tank. (See also W87-02437) (Lantz-PTT) JF - The Second Annual Eastern Regional Ground Water Conference July 16-18, 1985, Portland, Maine. 1985. p 165-181, 9 fig, 2 ref. AU - Scheinfeld, R A AD - Veterans Administration Hospital Denver, CO Y1 - 1985/07// PY - 1985 DA - Jul 1985 KW - Water Resources Abstracts KW - Monitoring KW - Underground waste disposal KW - Storage tanks KW - Water pollution control KW - Measuring instruments KW - Groundwater pollution KW - Thermal conductivity KW - Resistivity KW - Solubility KW - Grab samplers KW - Refractivity KW - Permeability KW - SW 3070:Water quality control KW - SW 0840:Groundwater UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19018914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Available+Technology+for+the+Monitoring+of+Underground+Storage+Tanks&rft.au=Scheinfeld%2C+R+A&rft.aulast=Scheinfeld&rft.aufirst=R&rft.date=1985-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - LOS ANGELES FEDERAL CENTER MASTER PLAN, CALIFORNIA. AN - 36396929; 283 AB - PURPOSE: Construction is proposed of a three-structure federal center complex in downtown Los Angeles, California. The project would consist of a Federal Building/Courthouse, a Metropolitan Detention Center, and a Veterans Administration Outpatient Clinic for a total of 1.3 million square feet of new building area on 6.7 undeveloped acres within an 11.1-acre site, situated to the east of the present Federal Building at 300 North Los Angeles Street. The 23-story Federal Building/Courthouse would be centrally located on the project site and would provide 800,000 gross square feet of building space for offices, court and adjunct offices, and joint-use facilities. A four-level garage would be built under this structure, with parking for 1,200 vehicles. The 13-story Metropolitan Detention Center would be situated on the northeast corner of the site and would provide 272,258 gross square feet of space for a 554-bed, single-cell facility for the short-term detention of federal prisoners. The six-story Outpatient Clinic would be located on the southeast corner of the site and would consist of 222,000 gross square feet of space for medical facilities. Parking would be provided under the clinic in a three- to four-level subterranean garage with parking stalls for 367 to 525 vehicles. POSITIVE IMPACTS: The coordinated federal complex would decrease the government's dependence on leased space in downtown Los Angeles. The Federal Building/Courthouse would provide space for expanding General Services Administration tenant agencies, including courts and executive branch agencies. The Outpatient Clinic would replace the existing clinic housed in a leased building that does not meet federal seismic standards. The Detention Center would eliminate the need to detain prisoners at Terminal Island, freeing space at that facility for sentenced prisoners. The project would introduce a major employment activity center adjacent to the Little Tokyo Redevelopment Area and El Pueblo Historic Area. NEGATIVE IMPACTS: The project would increase automobile traffic in the area, degrading air quality and increasing noise levels. Parking needs would exceed the onsite parking supply by 3,000 cars. The project density would be too high for the site, and the project design would be inconsistent with the small-scale, pedestrian orientation of the surrounding area. The project would be built on the site of an existing parking lot that may contain archaeological and paleontological artifacts below the surface. JF - EPA number: 850198, 242 pages, May 10, 1985 PY - 1985 KW - Urban and Social Programs KW - Air Quality KW - Archaeological Sites Surveys KW - Buildings KW - Central Business Districts KW - Community Development KW - Employment KW - Historic Sites Surveys KW - Hospitals KW - Noise Assessments KW - Paleontological Sites KW - Parking KW - Prisons KW - Site Planning KW - Socioeconomic Assessments KW - Traffic Analyses KW - Urban Structures KW - California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36396929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1985-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=LOS+ANGELES+FEDERAL+CENTER+MASTER+PLAN%2C+CALIFORNIA.&rft.title=LOS+ANGELES+FEDERAL+CENTER+MASTER+PLAN%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Real Estate Division, San Francisco, California; GSA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: May 10, 1985 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Identifying Patients Who Need Social Work Services: An Interdisciplinary Analysis AN - 1761716372; 198700581 AB - Factors that influence different professionals to refer patients for social work services are examined, based on the decisions of an interdisciplinary team, consisting of 1 MD, 2 social workers, & 2 nurses, regarding 102 patients admitted to a Veterans Administration Medical Center in West Haven, Conn, between Nov 1980 & Jan 1981. Statistical analyses reveal that patients' baseline functional status was the criterion most often used to assess the need for services; the importance of other variables is discussed, along with interdisciplinary professional differences. Implications for future social work training programs are discussed. 4 Tables. K. Hyatt JF - Social Work AU - Dove, Henry G AU - Schneider, Karen C AU - Gitelson, David A AD - Veterans Administration Medical Center, West Haven CT 06516 Y1 - 1985/05// PY - 1985 DA - May 1985 SP - 214 EP - 218 VL - 30 IS - 3 SN - 0037-8046, 0037-8046 KW - medical professionals, social work referrals KW - case records KW - Veterans Administration Medical Center, West Haven, Connecticut KW - Referral KW - Physicians KW - Social Work Cases KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761716372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work&rft.atitle=Identifying+Patients+Who+Need+Social+Work+Services%3A+An+Interdisciplinary+Analysis&rft.au=Dove%2C+Henry+G%3BSchneider%2C+Karen+C%3BGitelson%2C+David+A&rft.aulast=Dove&rft.aufirst=Henry&rft.date=1985-05-01&rft.volume=30&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Social+Work&rft.issn=00378046&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work Cases; Physicians; Referral ER - TY - JOUR T1 - The Aging Marital System: A Case Study in Life Changes and Paradoxical Intervention AN - 61612556; 198500813 AB - Marital therapy is illustrated by a case study of an older couple with long-standing marital conflict, which was exacerbated by life changes after retirement. Because of the history of conflict, current problems were resistant to directive forms of therapy. Paradoxical interventions were used to deal with this resistance. Several explanations of how paradox works are offered, & recommendations are made for the use of paradoxical therapy with older adults. 13 References. HA. JF - Clinical Gerontologist AU - Gilewski, Michael J AU - Kuppinger, Joyce AU - Zarit, Steven H AD - Veterans Administration Outpatient Clinic, 425 South Hill St Los Angeles CA 90013 Y1 - 1985/04// PY - 1985 DA - April 1985 SP - 3 EP - 15 VL - 3 IS - 3 SN - 0731-7115, 0731-7115 KW - marital therapy, elderly, paradoxical intervention KW - case study KW - Psychotherapy/Psychotherapeutic KW - Elder/Elders/Elderly KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61612556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=The+Aging+Marital+System%3A+A+Case+Study+in+Life+Changes+and+Paradoxical+Intervention&rft.au=Gilewski%2C+Michael+J%3BKuppinger%2C+Joyce%3BZarit%2C+Steven+H&rft.aulast=Gilewski&rft.aufirst=Michael&rft.date=1985-04-01&rft.volume=3&rft.issue=3&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Psychotherapy/Psychotherapeutic ER - TY - JOUR T1 - Pelvic exenteration AN - 754564164; 13379858 AB - Sixty-eight patients at the University of Illinois, Cook County, and the West Side Veterans Administration hospitals underwent pelvic exenteration for advanced pelvic malignancies during the 15-year period from 1969 to 1984. Thirty-two had colorectal cancers, eleven cervical, seven bladder, and six vulvar; in twelve the cancers were in miscellaneous pelvic sites. Forty-five exenterations were done with intent to cure, and twenty-three for palliation of patients with bulky, necrotic tumors that had caused symptomatic fistulae, local sepsis, chronic bleeding, or severe localized pain. The total 30-day postoperative mortality was 4.4% (3/68). The 5-year survival rate of patients who underwent curative exenteration was 33% (median 27 months). Pelvic exenteration appears to be a feasible surgical procedure for a variety of advanced malignancies as well as for palliation of severely symptomatic patients. JF - Journal of Surgical Oncology AU - Lindsey, William F AU - Wood, Donald K AU - Briele, Henry A AU - Greager, John A AU - Walker, Michael J AU - Bork, Jeffrey AU - Gupta, Tapas K Das AD - Division of Surgical Oncology, Department of Surgery, University of Illinois College of Medicine at Chicago, Cook County Hospital, the West Side Veterans Administration Hospital, and the Hektoen Institute for Medical Research, Chicago PY - 1985 SP - 231 EP - 234 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 30 IS - 4 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Urinary bladder KW - Colorectal cancer KW - Survival KW - Pain KW - Tumors KW - Palliation KW - Pelvis KW - Sepsis KW - Malignancy KW - Fistulae KW - Bleeding KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754564164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Pelvic+exenteration&rft.au=Lindsey%2C+William+F%3BWood%2C+Donald+K%3BBriele%2C+Henry+A%3BGreager%2C+John+A%3BWalker%2C+Michael+J%3BBork%2C+Jeffrey%3BGupta%2C+Tapas+K+Das&rft.aulast=Lindsey&rft.aufirst=William&rft.date=1985-02-01&rft.volume=30&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930300409 L2 - http://www3.interscience.wiley.com/journal/112722033/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Mortality; Urinary bladder; Colorectal cancer; Survival; Pain; Tumors; Palliation; Pelvis; Malignancy; Sepsis; Fistulae; Bleeding; Hospitals DO - http://dx.doi.org/10.1002/jso.2930300409 ER - TY - JOUR T1 - Hemicorporectomy AN - 754561435; 13379857 AB - Translumbar amputation (hemicorporectomy) was first successfully performed in 1961 after cadaver feasibility dissections. It is useful for certain slow-growing malignancies of the pelvis and perineum and for patients with advanced sepsis involving pelvic bony structures. As indicated by our 20-year experience, the operation may be rewarded by control of a malignant process (two patients) and/or relief from chronic pelvic sepsis (four patients), survival and discharge from the hospital after lengthy rehabilitation (six patients). JF - Journal of Surgical Oncology AU - Aust, J Bradley AU - Page, Carey P AD - Department of Surgery, University of Texas Health Science Center at San Antonio and Audie Murphy Veterans Administration Hospital, San Antonio, Texas PY - 1985 SP - 226 EP - 230 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 30 IS - 4 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts B: Bacteriology KW - Pelvis KW - Perineum KW - Sepsis KW - Malignancy KW - Rehabilitation KW - Amputation KW - Cadavers KW - Survival KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754561435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Hemicorporectomy&rft.au=Aust%2C+J+Bradley%3BPage%2C+Carey+P&rft.aulast=Aust&rft.aufirst=J&rft.date=1985-02-01&rft.volume=30&rft.issue=4&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930300408 L2 - http://www3.interscience.wiley.com/journal/112719685/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Perineum; Pelvis; Malignancy; Sepsis; Rehabilitation; Amputation; Cadavers; Survival; Hospitals DO - http://dx.doi.org/10.1002/jso.2930300408 ER - TY - JOUR T1 - Response of Pulmonary Energy Metabolism To Phosgene AN - 760215603; 13623378 AB - Rats were exposed to phosgene at a concentration of 1.0 ppm for 4 hours in a Rochester-type chamber. At intervals thereafter over a 4 day period, lungs were obtained for histological and biochemical assessments. Edema was estimated by histological examination and by measurement of lung wet and dry weights. In parallel studies, pulmonary mitochondrial respiratory activity was measured using Clark oxygen electrodes. The significant reduction in respiratory control index (State 3 respiration/State 4 respiration)found immediately following phosgene exposure coincided with the highest level of % lung water. There was a concomitant decrease of A TP concentration that persisted on the third day after exposure. Na-K-A TPase activity was reduced 1 day after exposure, thus a lowered A TP level preceded a reduction in Na-K-ATPase or sodium pump activity. The reduction in A TP level and Na-K-A TPase activity may play a major role in damage to lung tissue following exposure to phosgene. JF - Toxicology and Industrial Health AU - Currie, William D AU - Pratt, Philip C AU - Frosolono, M F AD - Division of Radiobiology, Department of Radiology and Department of Pathology, Duke University Medical Center and the Durham Veterans Administration Hospital, Durham, North Carolina 27710 Y1 - 1985 PY - 1985 DA - 1985 SP - 17 EP - 27 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 2 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Oxygen KW - Energy metabolism KW - Lung KW - Respiration KW - Electrodes KW - Mitochondria KW - Edema KW - phosgene KW - Na super(+)/K super(+)-exchanging ATPase KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760215603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Response+of+Pulmonary+Energy+Metabolism+To+Phosgene&rft.au=Currie%2C+William+D%3BPratt%2C+Philip+C%3BFrosolono%2C+M+F&rft.aulast=Currie&rft.aufirst=William&rft.date=1985-01-01&rft.volume=1&rft.issue=2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378500100203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 18 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Oxygen; Energy metabolism; Lung; Respiration; Electrodes; Edema; Mitochondria; Na super(+)/K super(+)-exchanging ATPase; phosgene DO - http://dx.doi.org/10.1177/074823378500100203 ER - TY - RPRT T1 - School Enrollment among Male Veterans and Nonveterans 20 to 34 Years Old [in] October 1983. Monograph 70-85-5. AN - 63213704; ED276814 AB - Data from the October 1983 education supplement to the Current Population Survey were examined to determine school enrollment of male veterans and nonveterans 20-34 years old. Overall, 16 percent of nonveterans and 11.1 percent of veterans were enrolled. Differences existed among 5-year age groups. Only in the youngest group, aged 20-24 years, were nonveterans more likely to be enrolled than veterans. Veterans in the two oldest groups, ages 25-29 and 30-34, were more likely to be enrolled in school than nonveterans. Veterans were much less likely than nonveterans to be enrolled below the college level, but they were more likely to be enrolled in "special schools." At the college level, enrollment for veterans and nonveterans was similar. Only a small proportion (about 7 percent) of both veterans and nonveterans employed full-time were enrolled in school. A much higher proportion of part-time workers were enrolled: 60 percent of veterans and over 70 percent of nonveterans. More than 26 percent of veterans and only about 10 percent of nonveterans who were full-time college students worked full-time. Between 1978 and 1983 the proportion of veterans enrolled in college declined; the proportion of nonveterans enrolled increased. (YLB) AU - Klein, Robert E. Y1 - 1985 PY - 1985 DA - 1985 SP - 43 VL - IM&S-M-70-85-5 KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Males KW - Young Adults KW - Enrollment Influences KW - Employment KW - Part Time Employment KW - Veterans KW - Comparative Analysis KW - Enrollment Trends KW - Enrollment KW - Employment Patterns KW - Veterans Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63213704?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Self-Care and the Politics of the Body in the Welfare State T2 - Mid-South Sociological Association AN - 61726247; 85S17113 AB - A social-historical perspective is taken toward self-help as an alternative health care movement in the US. During the opening decades of the nineteenth century, medical & social events resulted in an emphasis on individual responsibility for health. A strong reaction against medicine surfaced in the egalitarianism of the Jacksonian period of the 1820s & 1830s. It was accompanied by the belief that Americans could acquire adequate knowledge to deal with basic health needs. In the latter part of the nineteenth century & during the first half of the twentieth, this movement came under attack. It was first disqualified as unscientific & then, later, ignored. In the 1960s a number of social movements & ideologies developed reemphasizing self-help. Of critical importance are the social, economic, & political conditions of the reemergence of this movement. A preliminary inquiry into the social meanings of the concepts & practices surrounding self-help or individual responsibility for help, the conditions for its disappearance, & its resurrection & annexation into medical care is offered. JF - Mid-South Sociological Association AU - Belyea, Michael Y1 - 1985///0, PY - 1985 DA - 0, 1985 KW - health care, self-help movement, US KW - social-historical perspective KW - Self-help KW - Health care KW - proceeding KW - 3166: clinical sociology; clinical sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61726247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mid-South+Sociological+Association&rft.atitle=Self-Care+and+the+Politics+of+the+Body+in+the+Welfare+State&rft.au=Belyea%2C+Michael&rft.aulast=Belyea&rft.aufirst=Michael&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mid-South+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1985 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Aversive Therapies for Substance Abuse: Do They Work? AN - 61620192; 198601396 AB - Research over more than two decades in the use of aversive behavioral interventions for the treatment of drug & alcohol abuse is surveyed, covering the areas of conditioned aversive states (using chemicals or electrical stimuli) & extinction/desensitization. While many of these treatment interventions hold promise, none has been fully explored with properly controlled group studies. Suggestions are offered for evaluation of behavioral interventions for substance abuse to increase the clinical impact of this work. 30 References. HA JF - Journal of Substance Abuse Treatment AU - McLellan, A Thomas AU - Childress, Anna Rose AD - Veterans Administration Medical Center, University Ave Philadelphia PA 19104 Y1 - 1985///0, PY - 1985 DA - 0, 1985 SP - 187 EP - 191 VL - 2 IS - 3 SN - 0740-5472, 0740-5472 KW - substance abuse, aversive therapies' effectiveness KW - Substance Abuse KW - Treatment Programs KW - article KW - 6121: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61620192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Aversive+Therapies+for+Substance+Abuse%3A+Do+They+Work%3F&rft.au=McLellan%2C+A+Thomas%3BChildress%2C+Anna+Rose&rft.aulast=McLellan&rft.aufirst=A&rft.date=1985-01-01&rft.volume=2&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Programs; Substance Abuse ER - TY - JOUR T1 - A Diagnosis and Family Study of Posttraumatic Stress Disorder AN - 61615681; 198600473 AB - Interviews with 36 patients with chronic posttraumatic stress disorder revealed a positive history of familial psychopathology in 66% of the patients. Alcoholism, depression, & anxiety disorders were the disorders most commonly found. The patients also had a higher prevalence of alcoholic siblings than did a retrospectively derived control group of depressed & anxious M patients. With respect to the proportion of familial anxiety to familial depression, the probands with posttraumatic stress disorders more closely resembled probands with generalized anxiety than probands with depression. Every patient had experienced at least 1 significant psychiatric illness during his lifetime, most commonly alcohol abuse or depression. 1 Table, 9 References. HA JF - The American Journal of Psychiatry AU - Davidson, Jonathan AU - Swartz, Marvin AU - Storck, Michael AU - Krishnan, Ranga Rama AU - Hammett, Elliott AD - Veterans Administration Medical Center, Durham NC 27705 Y1 - 1985/01// PY - 1985 DA - January 1985 SP - 90 EP - 93 VL - 142 IS - 1 SN - 0002-953X, 0002-953X KW - posttraumatic stress disorder patients, family psychopathology history KW - interviews KW - Psychological Stress KW - Veterans KW - Family Relations KW - Mental Illness KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61615681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=A+Diagnosis+and+Family+Study+of+Posttraumatic+Stress+Disorder&rft.au=Davidson%2C+Jonathan%3BSwartz%2C+Marvin%3BStorck%2C+Michael%3BKrishnan%2C+Ranga+Rama%3BHammett%2C+Elliott&rft.aulast=Davidson&rft.aufirst=Jonathan&rft.date=1985-01-01&rft.volume=142&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Illness; Veterans; Psychological Stress; Family Relations ER - TY - JOUR T1 - Reducing the Treatment Drop Out Rate in Drug Abuse Programs AN - 61589901; 198600443 AB - Despite the endemic nature of the premature termination phenomenon in drug abuse programs, the drug treatment program at the West Side Veterans Administration Medical Center, Chicago, Ill, has successfully reduced patient attrition from 50% to 20%. The program's clinical & empirical exploration into the dropout process is described, along with the major administrative & clinical changes that reduced the dropout rate. Once staff recognize that patient dropouts are a staff problem rather than a patient problem, effective intervention can begin. 1 Table, 43 References. Modified HA JF - Journal of Substance Abuse Treatment AU - Craig, Robert J AD - West Side Veterans Administration Medical Center, 820 South Damen Ave Chicago IL 60612 Y1 - 1985///0, PY - 1985 DA - 0, 1985 SP - 209 EP - 219 VL - 2 IS - 4 SN - 0740-5472, 0740-5472 KW - dropout rate reduction, drug treatment program, West Side Veterans Administration Medical Center, Chicago, Illinois KW - Drug Addiction KW - Treatment Programs KW - Drug Abuse KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61589901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Reducing+the+Treatment+Drop+Out+Rate+in+Drug+Abuse+Programs&rft.au=Craig%2C+Robert+J&rft.aulast=Craig&rft.aufirst=Robert&rft.date=1985-01-01&rft.volume=2&rft.issue=4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Programs; Drug Abuse; Drug Addiction ER - TY - JOUR T1 - Ecology of Legionella pneumophila within Water Distribution Systems AN - 18972222; 8504264 AB - The potable water distribution system is the reservoir for hospital-acquired Legionnaires disease. The influence of the natural microbial population and sediment (scale and organic particulates) found in water systems as growth-promoting factors for Legionella pneumophila were investigated. Water from a hot-water storage tank readily supported the survival of L. pneumophila. The concentration of sediment was directly related to the survival of L. pneumophila; L. pneumophila did not survive in a sediment-free suspension. The presence of environmental bacteria improved the survival of L. pneumophila via nutritional symbiosis; the combination of sediment and environmental bacteria acted synergistically to improve the survival of L. pneumophila. The role of sediments in this synergistic effect was determined to be nutritional. Sediment stimulated the growth of environmental microflora, which in turn stimulated the growth of L. pneumophila. L. pneumophila occupies an ecological niche within the potable water system, with interrelationships between microflora, sediment, and temperature. It may be a misnomer to refer to water systems as being contaminated with L. pneumophila when this organisms merely represents one of hundreds of microorganisms which occupy an ecological niche in this environment. (Moore-IVI) JF - Applied and Environmental Microbiology Vol. 49, No. 1, p 221-228, January, 1985. 7 Fig, 2 Tab, 24 Ref. AU - Stout, JE AU - Yu, V L AU - Best, M G AD - Veterans Administration Medical Center Pittsburgh, PA Y1 - 1985/01// PY - 1985 DA - Jan 1985 KW - Water Resources Abstracts KW - Legionella KW - Water conveyance KW - Sediments KW - Heated water KW - Hospitals KW - Microorganisms KW - Potable water KW - Pathogenic bacteria KW - SW 3060:Water treatment and distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18972222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Ecology+of+Legionella+pneumophila+within+Water+Distribution+Systems&rft.au=Stout%2C+JE%3BYu%2C+V+L%3BBest%2C+M+G&rft.aulast=Stout&rft.aufirst=JE&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Tatlockia micdadei (Pittsburgh pneumonia agent) growth kinetics may explain its infrequent isolation from water and the low prevalence of Pittsburgh pneumonia AN - 13833911; 198503562 AB - Sediment and indigenous microflora, taken from water distribution systems, promoted survival of Legionella pneumophila. Growth and survival of Pittsburgh pneumonia agent (PPA) were not affected by sediment, with or without microflora. Symbiosis between PPA and 18 environmental organisms was demonstrated by in vitro satellitism experiments. However, when two of the symbiotic organisms (a pseudomonad and a flavobacterium) were incubated with PPA, either alone or in combination with sediment, survival of PPA was not enhanced. These observations might explain the infrequent presence and low concentrations of PPA in the water supply and, ultimately, the epidemiologic differences between Legionnaires disease and Pittsburgh pneumonia. JF - Applied and Environmental Microbiology AU - Best, M G AU - Stout, JE AU - Yu, V L AU - Muder, R R AD - Veterans Administration Medical Centre, Pittsburgh Y1 - 1985 PY - 1985 DA - 1985 SP - 1521 EP - 1522 VL - 49 IS - 6 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13833911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Tatlockia+micdadei+%28Pittsburgh+pneumonia+agent%29+growth+kinetics+may+explain+its+infrequent+isolation+from+water+and+the+low+prevalence+of+Pittsburgh+pneumonia&rft.au=Best%2C+M+G%3BStout%2C+JE%3BYu%2C+V+L%3BMuder%2C+R+R&rft.aulast=Best&rft.aufirst=M&rft.date=1985-01-01&rft.volume=49&rft.issue=6&rft.spage=1521&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - A Family Training Program for Adventitiously Blinded and Low Vision Veterans AN - 61548732; 198500595 AB - The family training program at the Western Blind Rehabilitation Center (Veterans Administration Medical Center, Palo Alto, Calif) is an integral part of the rehabilitation process for adventitiously blinded & low vision veterans. To assess which aspects of the training were most helpful & to see how the program affected interpersonal relations & attitudes toward sight loss, questionnaire responses of 93 family members of such veterans were analyzed. Results showed a marked reduction in stated problems immediately after the training & over a 3.5-year period. The findings demonstrate similar benefits for older family members, those participating in shortened programs, & those who have been living with sight loss for many years. 6 Tables, 5 References. Modified HA. JF - Journal of Visual Impairment and Blindness AU - Dumas, Arlene AU - Sadowsky, Alan D AD - Veterans Administration Medical Center, Palo Alto CA 94304 Y1 - 1984/12// PY - 1984 DA - December 1984 SP - 473 EP - 478 VL - 78 IS - 10 SN - 0145-482X, 0145-482X KW - sight loss attitudes interpersonal relations KW - visually impaired veterans' family training program KW - questionnaires KW - Western Blind Rehabilitation Program KW - Veteran/Veterans KW - Blind/Blindness KW - Training/Trainer KW - Family/Families KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61548732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visual+Impairment+and+Blindness&rft.atitle=A+Family+Training+Program+for+Adventitiously+Blinded+and+Low+Vision+Veterans&rft.au=Dumas%2C+Arlene%3BSadowsky%2C+Alan+D&rft.aulast=Dumas&rft.aufirst=Arlene&rft.date=1984-12-01&rft.volume=78&rft.issue=10&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visual+Impairment+and+Blindness&rft.issn=0145482X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Blind/Blindness; Family/Families; Training/Trainer; Veteran/Veterans ER - TY - JOUR T1 - Depression and Chronic Pain: The Mediating Role of the Spouse AN - 61010478; 85O8916 AB - Relationships among measures of pain intensity, depressed mood, marital satisfaction, & spouse supportiveness, were studied in a sample of 30 M, chronic pain patients & their wives. Over 50% of the Ss reported significant depression & marital dissatisfaction. The lack of a significant relationship between pain intensity & either depression or marital satisfaction, & the presence of significant correlations between depression & spouse-support measures is interpreted as support for a multidimensional, cognitive-behavioral model of depression among chronic pain patients. 3 Tables, 35 References. HA. JF - Journal of Marriage and the Family AU - Kerns, Robert D AU - Turk, Dennis C AD - Veterans Administration Medical Center, West Haven CT 06516 Y1 - 1984/11// PY - 1984 DA - November 1984 SP - 845 EP - 852 VL - 46 IS - 4 SN - 0022-2445, 0022-2445 KW - chronic pain/depression/marital dissatisfaction KW - spouse support KW - male pain patients/their wives KW - Patient/Patients KW - Depression KW - Satisfaction KW - Pain/Pains KW - Chronic/Chronically KW - Marriage/Marriages/Marital KW - Support/Supports/Supported/ Supporting/ Supportive KW - Spouse/Spousal KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61010478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+the+Family&rft.atitle=Depression+and+Chronic+Pain%3A+The+Mediating+Role+of+the+Spouse&rft.au=Kerns%2C+Robert+D%3BTurk%2C+Dennis+C&rft.aulast=Kerns&rft.aufirst=Robert&rft.date=1984-11-01&rft.volume=46&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+the+Family&rft.issn=00222445&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Chronic/Chronically; Pain/Pains; Patient/Patients; Depression; Marriage/Marriages/Marital; Satisfaction; Support/Supports/Supported/ Supporting/ Supportive; Spouse/Spousal ER - TY - JOUR T1 - Professional Responsibility: Confronting Sexual Abuse of People with Disabilities AN - 1463024694; 198800216 AB - Sexual abuse of people with disabilities has recently become a challenge for health professionals. Issues of professional responsibility in three areas -- clinical, management, & personal -- are discussed. Prevention of sexual assault is seen as a primary professional obligation. An outline is offered for development of a systematic approach to deal with the problem of sexual abuse within an institutional setting. 13 References. HA JF - Sexuality and Disability AU - Berkman, Anne AD - Veterans Administration Medical Center, First Ave/24th St New York NY 10010 Y1 - 1984/10// PY - 1984 DA - October 1984 SP - 89 EP - 95 VL - 7 IS - 3-4 SN - 0146-1044, 0146-1044 KW - disabled, sexual abuse, institutional guidelines development KW - Professional Ethics KW - Handicapped KW - Sexual Abuse KW - Mental Hospitals KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463024694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexuality+and+Disability&rft.atitle=Professional+Responsibility%3A+Confronting+Sexual+Abuse+of+People+with+Disabilities&rft.au=Berkman%2C+Anne&rft.aulast=Berkman&rft.aufirst=Anne&rft.date=1984-10-01&rft.volume=7&rft.issue=3-4&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Sexuality+and+Disability&rft.issn=01461044&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Sexual Abuse; Handicapped; Mental Hospitals; Professional Ethics ER - TY - JOUR T1 - Combat Adaptations of Vietnam Veterans without Posttraumatic Stress Disorders AN - 61079725; 85O4383 AB - Ten veterans who did not develop posttraumatic stress after intense combat in Vietnam were studied via a 5-session clinical evaluation to explain what had protected them. A highly consistent adaptation to combat was found: during combat, each of these veterans had exhibited calmness under pressure, intellectual control, acceptance of fear, & a lack of excessively violent or guilt-arousing behavior. It is suggested that these traits may be part of an adaptation uniquely suitable for preserving emotional stability in an unstructured, unstable context. 10 References. Modified HA. JF - The American Journal of Psychiatry AU - Hendin, Herbert AU - Haas, Ann Pollinger AD - Center Psychosocial Studies Veterans Administration Medical Center, Montrose NY 10548 Y1 - 1984/08// PY - 1984 DA - August 1984 SP - 956 EP - 960 VL - 141 IS - 8 SN - 0002-953X, 0002-953X KW - Vietnam veterans without posttraumatic stress disorders, combat adaptations KW - clinical evaluation KW - Veteran/Veterans KW - Stress/Stresses KW - Vietnam/Vietnamese KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61079725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Combat+Adaptations+of+Vietnam+Veterans+without+Posttraumatic+Stress+Disorders&rft.au=Hendin%2C+Herbert%3BHaas%2C+Ann+Pollinger&rft.aulast=Hendin&rft.aufirst=Herbert&rft.date=1984-08-01&rft.volume=141&rft.issue=8&rft.spage=956&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Vietnam/Vietnamese; Veteran/Veterans; Stress/Stresses ER - TY - RPRT T1 - Personal Income and Educational Attainment of Male War Veterans and Nonveterans, March 1983. Monograph 70-84-7. AN - 63372478; ED253747 AB - A study compared the personal income and educational attainment of male war veterans and nonveterans as of March 1983. Using data from the March supplement of the 1983 Current Population Survey, the researchers compared the educational attainment and income of 9 separate age groups of a sample of 22,823 veterans and 47,792 nonveterans. For the most part, male war veterans had higher personal income and higher educational attainment than nonveterans. However, the relative difference in median income for Vietnam-era veterans--those 25 to 39 years old--was smaller than the relative difference between veterans and nonveterans of all ages combined. Since veterans were overrepresented in the relatively high-income-earning middle and older ages, part of the difference in income between veterans and nonveterans could be attributed to their age differences; if veterans had the same proportionate age distribution as nonveterans, then their median income would fall by one-fifth. The differences in educational attainment between veterans and nonveterans had also diminished; whereas veterans had distinctly higher educational attainment than nonveterans in 1973, the gap in median education virtually disappeared by 1983. (Appendixes to this report contain three tables summarizing educational attainment and income levels by age group as well as an explanation of the age-adjustment techniques used in the study to arrive at median education levels.) (MN) AU - Klein, Robert E. Y1 - 1984/07// PY - 1984 DA - July 1984 SP - 33 KW - Current Population Survey KW - ERIC, Resources in Education (RIE) KW - Influences KW - Postsecondary Education KW - Age KW - Socioeconomic Status KW - Males KW - Elementary Secondary Education KW - Educational Trends KW - Educational Attainment KW - Income KW - Veterans KW - Comparative Analysis KW - Salary Wage Differentials KW - Trend Analysis KW - Education Work Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63372478?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Effectiveness of Different Group Structures for Schizophrenic, Character-Disordered, and Normal Groups AN - 61613412; 198501095 AB - It is hypothesized that schizophrenic & character-disordered groups have different preferences for the level of structure, or differentiation, in the group environment: schizophrenics will prefer groups characterized by low levels of complexity, while character-disordered patients will prefer groups high in differentiation & low in fusion. Schizophrenics (N = 21) & character-disordered adolescents (N = 21), divided into 6 homogeneous groups, received 2 types of dance therapy: one in which unison movement was used, & another in which highly differentiated games were used. Degree of participation was measured by the Structural Analysis of Movement Sessions (SAMS) scale by trained raters who viewed videotapes of the sessions. Preference was measured by a multiple choice questionnaire. Results showed strong support for the hypotheses: schizophrenics preferred & felt less anxious in the less differentiated session, while character-disordered Ss preferred & participated more actively in the highly differentiated session. No differentiation was found among 3 groups of Coll students who served as controls. The results give support to the concept of person-environment "match," in which the degree of a person's comfort (or conversely, anxiety) & involvement in a setting is influenced by the degree to which the setting is structured in a manner congruent with the person's internal personality structure. The data predict, for example, that inpatient programs for character-disordered patients are likely to be highly structured, with explicit rule systems, competitive group activities, & well-delineated roles. 4 Figures, 31 References. AA. JF - International Journal of Group Psychotherapy AU - Johnson, David Read AU - Sandel, Susan L AU - Bruno, Carol AD - Veterans Administration Medical Center, West Spring St West Haven CT 06516 Y1 - 1984/07// PY - 1984 DA - July 1984 SP - 415 EP - 429 VL - 34 IS - 3 SN - 0020-7284, 0020-7284 KW - group therapy structure's effectiveness, schizophrenic/character-disordered/normal groups KW - videotaped sessions, questionnaire KW - Group therapy KW - Schizophrenia/Schizophrenic/ Schizophrenics KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61613412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Group+Psychotherapy&rft.atitle=Effectiveness+of+Different+Group+Structures+for+Schizophrenic%2C+Character-Disordered%2C+and+Normal+Groups&rft.au=Johnson%2C+David+Read%3BSandel%2C+Susan+L%3BBruno%2C+Carol&rft.aulast=Johnson&rft.aufirst=David&rft.date=1984-07-01&rft.volume=34&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Group+Psychotherapy&rft.issn=00207284&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Group therapy; Schizophrenia/Schizophrenic/ Schizophrenics ER - TY - JOUR T1 - "Hedonism" Is No Fun: Notes on Burgess's "Hedonism" Construct AN - 60063850; 85O6946 AB - In an attempt to clarify the role of extraversion & neuroticism in criminal behavior, P. K. Burgess (see SA 21:6/73G5513) argued that the propensity to commit criminal acts is a function of a person's "hedonism," capriciously defined as the arithmetic product of extraversion & neuroticism scales of the Eysenck Personality Questionnaire. Psychometrically & conceptually, this concatenation makes no sense. The construct validity of "hedonism" is given a detailed examination in comparison with other measures of hedonic capacity. Undergraduates (N = 84 Fs & 16 Ms) completed 6 measures, which were then intercorrelated & examined. Convergent, discriminant, & construct validity were lacking, suggesting that "hedonism" does not measure what its name implies. Notes on the validation & naming of constructs are included. 1 Table, 16 References. AA. JF - British Journal of Criminology AU - Peterson, Charles A AD - Veterans Administration Lakeside Medical Center, 333 East Huron St Chicago IL 60611 Y1 - 1984/07// PY - 1984 DA - July 1984 SP - 296 EP - 300 VL - 24 IS - 3 SN - 0007-0955, 0007-0955 KW - criminal behavior propensity, P. K. Burgess's "hedonism" construct validity KW - hedonic capacity KW - Eysenck Personality Questionnaire KW - undergraduates KW - Criminal/Criminals/Criminality/Criminally (see also Crime) KW - Hedonism/Hedonistic KW - Behavior/Behavioral KW - article KW - 1636: social control; sociology of law UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60063850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Criminology&rft.atitle=%22Hedonism%22+Is+No+Fun%3A+Notes+on+Burgess%27s+%22Hedonism%22+Construct&rft.au=Peterson%2C+Charles+A&rft.aulast=Peterson&rft.aufirst=Charles&rft.date=1984-07-01&rft.volume=24&rft.issue=3&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Criminology&rft.issn=00070955&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - BJCDAR N1 - SubjectsTermNotLitGenreText - Criminal/Criminals/Criminality/Criminally (see also Crime); Behavior/Behavioral; Hedonism/Hedonistic ER - TY - JOUR T1 - Group Treatment of Physically Disabled Adults by Telephone AN - 61556121; 198400598 AB - Physical disability impinges on a person's lifestyle & can be detrimental in its effects on mood & activity. A counseling program initiated at the Veterans Administration Medical Center in Seattle, Wash, for severely disabled persons is described, utilizing telephone support groups to solve problems related to feeling discouraged & lonely, or to being too inactive to remain healthy. Many participants (N = 173, of 269 interviewed) reported being less anxious & more socially involved as a result of the intervention. The ease with which the groups were conducted & positive feedback from participants suggest the advisability of further research to evaluate the cost effectiveness of phone intervention & explore potential of treating affective problems with scheduled phone contact. 7 References. Modified HA. JF - Social Work in Health Care AU - Evans, Ron L AU - Fox, Harold R AU - Pritzl, Denise O AU - Halar, Eugen M AD - Veterans Administration Medical Center, 122 South Columbian Way Seattle WA 98108 Y1 - 1984/04// PY - 1984 DA - April 1984 SP - 77 EP - 84 VL - 9 IS - 3 SN - 0098-1389, 0098-1389 KW - group counseling via telephone, physically disabled adults KW - interviews KW - Veterans Administration Medical Center, Seattle, Washington KW - Adult/Adults/Adulthood KW - Physical handicap/Physically handicapped KW - Counsel/Counseling/Counselor/ Counselors KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61556121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Group+Treatment+of+Physically+Disabled+Adults+by+Telephone&rft.au=Evans%2C+Ron+L%3BFox%2C+Harold+R%3BPritzl%2C+Denise+O%3BHalar%2C+Eugen+M&rft.aulast=Evans&rft.aufirst=Ron&rft.date=1984-04-01&rft.volume=9&rft.issue=3&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Physical handicap/Physically handicapped; Adult/Adults/Adulthood; Counsel/Counseling/Counselor/ Counselors ER - TY - JOUR T1 - Growing Interest in Alcohol and Human Sexuality Revealed in the Literature from 1941-1980 AN - 60970331; 87R6406 AB - An extensive search of the literature on alcohol & human sexual behavior from 1941-1980 identified 496 citations, consisting of 422 (85%) English language & 74 (15%) foreign language articles. Content of the citations fell into three inductively derived categories: (1) material examining the psychological & physiological effects of alcohol on sexual function; (2) material on sexual problems of alcoholics; & (3) a composite category of social problems & cultural issues (eg, sexual deviance, cross-cultural studies). The literature during this period showed a gradual but consistent increase in citations, culminating in a dramatic increase in the 1970s. The materials came from publications of various research & clinical disciplines, with no one type of reader having access to the majority of the literature. The problem of access to this widely diverse literature was compounded by the fact that complete translations of the foreign language articles were virtually not available. The citations examined here focused to a greater extent on Ms than Fs. 3 Tables, 1 Figure, 11 References. HA JF - Sexuality and Disability AU - O'Farrell, Timothy AU - Thompson, Diane Logan AU - Weyand, Carolyn A AD - Alcohol & Family Studies Laboratory Veterans Administration Medical Center & Harvard Medical School, Brockton MA 02401 Y1 - 1984/04// PY - 1984 DA - Apr 1984 SP - 51 EP - 63 VL - 7 IS - 1 -- 2 SN - 0146-1044, 0146-1044 KW - alcoholism, sexual dysfunction KW - citation analysis KW - 1941-1980 KW - *Alcoholism KW - *Sexuality KW - *Sexual Dysfunction KW - article KW - 1940: the family and socialization; sociology of sexual behavior KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60970331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexuality+and+Disability&rft.atitle=Growing+Interest+in+Alcohol+and+Human+Sexuality+Revealed+in+the+Literature+from+1941-1980&rft.au=O%27Farrell%2C+Timothy%3BThompson%2C+Diane+Logan%3BWeyand%2C+Carolyn+A&rft.aulast=O%27Farrell&rft.aufirst=Timothy&rft.date=1984-04-01&rft.volume=7&rft.issue=1+--+2&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Sexuality+and+Disability&rft.issn=01461044&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2011-12-15 N1 - CODEN - SDISDC N1 - SubjectsTermNotLitGenreText - *Alcoholism; *Sexuality; *Sexual Dysfunction ER - TY - RPRT T1 - Work Experience and Income of Male Veterans and Nonveterans in 1981. AN - 63221363; ED274796 AB - The work experience and income of male veterans, aged 20 years and over, were compared with that of their nonveteran counterparts for the calendar year 1981. Analysis of the data provided by the Census Bureau showed that a larger percentage of male veterans than of their nonveteran counterparts, 64 percent and 56 percent, respectively, worked full-time all year round during 1981. As a result, veterans had a higher overall median income than nonveterans. Age differences between the two groups, however, accounted for much of this disparity in income and work experience. Veterans comprised an older group than nonveterans, and consequently fewer of them were at the ages that are at greatest risk of being totally or partly unemployed during the year. (In addition to two tables and four figures within the text of the report, 10 tables are appended that present in greater detail the data discussed in the text.) (YLB) AU - Langberg, Robert Y1 - 1984/01// PY - 1984 DA - January 1984 SP - 60 VL - RSM-70-84-2 KW - ERIC, Resources in Education (RIE) KW - Veterans KW - Work Experience KW - Comparative Analysis KW - Males KW - Employment KW - Adults KW - Income UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63221363?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Social Work and Alzheimer's Disease: Psychosocial Management in the Absence of Medical Care AN - 61591132; 198500216 AB - Because the illness erodes & destroys an individual's humanness & personality, patients & families affected by Alzheimer's Disease have particularly critical needs for help with its psychosocial sequelae. A model of psychosocial management is described & specific interventions that help patients & caregivers develop & maintain adaptations during the long course of the disease are detailed. 1 Table, 17 References. HA. JF - Social Work in Health Care AU - Berman, Stephen AU - Rappaport, Meryl B AD - Veterans Administration Medical Center, Palo Alto CA 94304 Y1 - 1984/01// PY - 1984 DA - January 1984 SP - 53 EP - 70 VL - 10 IS - 2 SN - 0098-1389, 0098-1389 KW - Alzheimer's Disease, social work, patient/caregivers psychosocial management model KW - Disease/Diseases KW - Patient/Patients KW - Social work KW - Care givers KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61591132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Social+Work+and+Alzheimer%27s+Disease%3A+Psychosocial+Management+in+the+Absence+of+Medical+Care&rft.au=Berman%2C+Stephen%3BRappaport%2C+Meryl+B&rft.aulast=Berman&rft.aufirst=Stephen&rft.date=1984-01-01&rft.volume=10&rft.issue=2&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Disease/Diseases; Social work; Patient/Patients; Care givers ER - TY - JOUR T1 - Legislative Policy and Resource Allocation in Involuntary Civil Commitment AN - 61027198; 84O1993 AB - The interplay of market controls & social controls in the health care industry is discussed. The mental health care system is seen as an example of these dual controls, which operate as driving forces in the complex human services system. A conceptual framework is presented that demonstrates the effects of one type of regulatory control, legislative change, on the social control of behavior & the allocation of scarce economic resources. A case example is developed based on a change in involuntary civil commitment legislation in Wash. Following a discussion of recent developments in mental health law & the community's response to those changes, the intra- & intersystem effects in the quantity, quality, & cost of mental health care are discussed relative to the regulatory objectives intended by the legal intervention. 2 Tables, 2 Figures, 65 References. Modified AA. JF - Research in the Sociology of Health Care AU - Durham, Mary L AU - Pierce, Glenn L AU - Fisher, William H AD - American Lake Veterans Administration Medical Center, Tacoma WA 98493 Y1 - 1984///0, PY - 1984 DA - 0, 1984 SP - 135 EP - 157 VL - 3 SN - 0275-4959, 0275-4959 KW - health care industry KW - legislative policy/resource allocation KW - involuntary civil commitment KW - Washington KW - Health care KW - Resource/Resources KW - Legislation (see also Law, Legal) KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61027198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+the+Sociology+of+Health+Care&rft.atitle=Legislative+Policy+and+Resource+Allocation+in+Involuntary+Civil+Commitment&rft.au=Durham%2C+Mary+L%3BPierce%2C+Glenn+L%3BFisher%2C+William+H&rft.aulast=Durham&rft.aufirst=Mary&rft.date=1984-01-01&rft.volume=3&rft.issue=&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Research+in+the+Sociology+of+Health+Care&rft.issn=02754959&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - RSHCDJ N1 - SubjectsTermNotLitGenreText - Health care; Legislation (see also Law, Legal); Resource/Resources ER - TY - JOUR T1 - Age-Based Transition Periods and the Outcome of Mental Health Treatment AN - 1761722252; 198501999 AB - To explore the impact of patient age on responsiveness to mental health treatment, interview data from a stratified random sample of patients (N = 303) at the Reno, Nev, Veterans Administration Medical Center were analyzed in terms of D. J. Levenson's proposed adult development schema (The Seasons of a Man's Life, New York: Alfred A. Knopf, 1978). Results revealed that improvement during treatment was significantly related to the patient's developmental stage (r = .25, p < .01). Furthermore, patients treated during transition periods exhibited the greatest improvement. Results were cross-validated & replicated using 3 alternate techniques of improvement measurement. The usefulness of this technique in research concerned with the evaluation of treatment facility effectiveness is thus supported. 2 Tables, 1 Figure, 29 References. Modified HA. JF - Evaluation and Program Planning AU - Smith, Aaron AU - Cardillo, Joseph E AU - Choate, Robert O AD - Veterans Administration Medical Center, 1000 Locust St Reno NV 89520 Y1 - 1984///0, PY - 1984 DA - 0, 1984 SP - 237 EP - 244 VL - 7 IS - 3 SN - 0149-7189, 0149-7189 KW - mental health treatment response KW - patient's age KW - interviews KW - Reno, Nevada, Veterans Administration Medical Center patients KW - Mental health KW - Treatment KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761722252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+and+Program+Planning&rft.atitle=Age-Based+Transition+Periods+and+the+Outcome+of+Mental+Health+Treatment&rft.au=Smith%2C+Aaron%3BCardillo%2C+Joseph+E%3BChoate%2C+Robert+O&rft.aulast=Smith&rft.aufirst=Aaron&rft.date=1984-01-01&rft.volume=7&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Evaluation+and+Program+Planning&rft.issn=01497189&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental health; Treatment ER - TY - JOUR T1 - Role of stagnation and obstruction of water flow in isolation of Legionella pneumophila from hospital plumbing AN - 13841501; 198500865 AB - Colony counts of L. pneumophila fell rapidly to undetectable levels in two hot water tanks that were kept continually used for one year whereas counts in two stagnant tanks, which were not in use, remained high. L. pneumophila was also isolated from tap aerators and vacuum breakers but not from unobstructed taps or backflow inhibitors. These data suggest that prevention of stagnation in hot water tanks may reduce L. pneumophila concentrations in plumbed systems and that fixtures which obstruct water flow can act as secondary reservoirs for the organism. JF - Applied and Environmental Microbiology AU - Ciesielski, CA AU - Blaser, MJ AU - Wang, WLL AD - Veterans Administration Medical Centre, Denver, Colo. Y1 - 1984 PY - 1984 DA - 1984 SP - 984 EP - 987 IS - 5 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13841501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Role+of+stagnation+and+obstruction+of+water+flow+in+isolation+of+Legionella+pneumophila+from+hospital+plumbing&rft.au=Ciesielski%2C+CA%3BBlaser%2C+MJ%3BWang%2C+WLL&rft.aulast=Ciesielski&rft.aufirst=CA&rft.date=1984-01-01&rft.volume=&rft.issue=5&rft.spage=984&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Relationship between nutrition and dementia in the elderly. AN - 80969354; 6599862 AB - The complexities of physiologic interactions between the nutritional status of the aged and the incidence of dementia in the elderly should be obvious from this partial survey of the field. Investigations aimed at delineating the role of individual nutrients in mentation among the elderly are extremely difficult to design and perform. However, the potential for practical applications of the results is indeed very high. The studies discussed in this article permit the following conclusions. Although many attempts have been made to enhance average life expectancy through nutritional manipulation, no such panacea currently exists. There is a well-documented decrease in caloric intake among the elderly. However, this does not seem to put them at any higher risk of developing overt deficiencies of specific nutrients. The elderly population in this country has a strong tendency to consume nutritional supplements, with vitamins C and E being the most popular. It is unknown at present whether this practice has any health value. Several attempts have been made to alter the course of dementia in the elderly through nutritional means. Attempts to ameliorate the symptoms of Alzheimer's disease through use of choline and lecithin have been overwhelmingly unsuccessful. The postulate that aluminum toxicity is an etiologic factor in this disease remains unproven, and therapies with chelating agents are not now advisable. Vitamin B12 has to be seriously considered as a causative factor in dementia; it is hoped that methods to test vitamin B12 nutriture in humans that are both more reliable and more capable of revealing marginal deficiency states will emerge. Although folic acid is intimately related biochemically and nutritionally to vitamin B12, its potential role in normal mental function remains largely unknown. Clearly, when considering nutrition and dementia in the elderly, there are many areas that still require thorough scientific investigation. Hopefully, the future will see an increase in research activity, resulting in answers to many of the questions posed in this paper. JF - Psychiatric medicine AU - Vatassery, G T AU - Maletta, G J AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1983/12// PY - 1983 DA - December 1983 SP - 429 EP - 443 VL - 1 IS - 4 SN - 0732-0868, 0732-0868 KW - Phosphatidylcholines KW - 0 KW - Folic Acid KW - 935E97BOY8 KW - Aluminum KW - CPD4NFA903 KW - Choline KW - N91BDP6H0X KW - Acetylcholine KW - N9YNS0M02X KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Choline -- pharmacology KW - Thiamine Deficiency -- complications KW - Nutritional Requirements KW - Aged, 80 and over KW - Vitamin B 12 -- pharmacology KW - Psychoses, Alcoholic -- etiology KW - Humans KW - Folic Acid -- pharmacology KW - Aged KW - Aluminum -- toxicity KW - Acetylcholine -- pharmacology KW - Phosphatidylcholines -- pharmacology KW - Nutritional Status KW - Cognition -- drug effects KW - Dementia -- etiology KW - Aging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80969354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+medicine&rft.atitle=Relationship+between+nutrition+and+dementia+in+the+elderly.&rft.au=Vatassery%2C+G+T%3BMaletta%2C+G+J&rft.aulast=Vatassery&rft.aufirst=G&rft.date=1983-12-01&rft.volume=1&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Psychiatric+medicine&rft.issn=07320868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Survey of Aging Veterans: A Study of the Means, Resources and Future Expectations of Veterans Aged 55 and Over. AN - 63206939; ED274799 AB - A national survey of the needs, resources, and future expectations of veterans aged 55 and over produced findings that the Veterans Administration (VA) will use over the next decade to plan facilities and programs to meet those needs. Findings indicated veterans had a higher educational level and were less likely to be at the lower end of the occupational scale than non-veterans of the same age. Retired veterans were substantially better off. Three-fourths had savings accounts, 42 percent had other investments, and nearly 9 out of 10 owned their own home. Although the majority described their health as excellent or good compared to others their own age, nearly half reported that their health limited their activities. Certain types of chronic diseases, including arthritis and hypertension, were widespread. While four of five veterans had group or private health insurance, Medicare formed the cornerstone of the aging veterans' health coverage. The survey identified, however, the existence of a medically indigent group of veterans. Most veterans did not believe they would be able to absorb the cost of future long-term care needs. An important finding was that current utilization rates of VA hospitals by aging veterans may drastically underrepresent the true demand. (Numerous data tables are provided. The questionnaire is appended.) (YLB) Y1 - 1983/12// PY - 1983 DA - December 1983 SP - 367 VL - RSM-70-84-3 KW - Veterans Administration KW - ERIC, Resources in Education (RIE) KW - Health KW - Needs Assessment KW - National Surveys KW - Retirement KW - Participant Satisfaction KW - Veterans KW - Demography KW - Older Adults KW - Health Needs KW - Attitudes KW - Health Insurance KW - Use Studies KW - Economic Status KW - Middle Aged Adults KW - Early Retirement KW - Medical Services KW - Futures (of Society) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63206939?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Suicide in the Elderly: The Limits of Paternalism AN - 61589082; 198400257 AB - A discussion of problems in the care of the suicidal elderly is presented, illustrated by the case of a suicidal, recently widowed man. It is argued that paternalism is not always in the best interests of the patient, & that caregivers would be wise to respect the autonomy of the patient in making decisions. The majority of professionals involved in the care of the elderly believe that suicidal depression is an illness that should be treated; however, this belief is strongly contested by those, eg, Thomas Szasz, who hold that suicide is a form of "self-determination" & should be respected as a rational act (see SA 22:1/74G6256). Some philosophical, religious, & medical considerations about suicide are presented in a historical perspective. 21 References. Modified HA. JF - Journal of the American Geriatrics Society AU - Bromberg, Shirley AU - Cassel, Christine K AD - Portland Veterans Administration Medical Center, OR 97201 Y1 - 1983/11// PY - 1983 DA - November 1983 SP - 698 EP - 703 VL - 31 IS - 11 SN - 0002-8614, 0002-8614 KW - suicidal elderly KW - paternalism's limits, caregivers' responsibilities, philosophical/religious/medical considerations KW - Paternal/Paternalism/Paternalist/ Paternalistic KW - Elder/Elders/Elderly KW - Suicide/Suicides/Suicidal KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61589082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Suicide+in+the+Elderly%3A+The+Limits+of+Paternalism&rft.au=Bromberg%2C+Shirley%3BCassel%2C+Christine+K&rft.aulast=Bromberg&rft.aufirst=Shirley&rft.date=1983-11-01&rft.volume=31&rft.issue=11&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Suicide/Suicides/Suicidal; Elder/Elders/Elderly; Paternal/Paternalism/Paternalist/ Paternalistic ER - TY - JOUR T1 - Improved Exercise Myocardial Perfusion During Lidoflazine Therapy AN - 20078690; 10099726 AB - Lidoflazine is a synthetic drug with calcium-channel blocking effects. In a study of 6 patients with severe classic angina pectoris, single-blind administra tion of lidoflazine was associated with improved myocardial perfusion during exercise as determined by thallium-201 stress scintigraphy. These studies demonstrate that lidoflazine therapy is associated with relief of angina, an increased physical work capacity, and improved regional myocardial perfusion during exercise. JF - Angiology AU - Shapiro, William AU - Narahara, Kenneth A AU - Park, Janet AD - Medical Service, Cardiovascular Section, Veterans Administration Medical Center, University of Texas Southwestern Medical School, Dallas, Texas Y1 - 1983/11// PY - 1983 DA - Nov 1983 SP - 705 EP - 710 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 34 IS - 11 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Work capacity KW - Physical therapy KW - Therapy KW - Stress KW - Patients KW - Exercise KW - Drugs KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Improved+Exercise+Myocardial+Perfusion+During+Lidoflazine+Therapy&rft.au=Shapiro%2C+William%3BNarahara%2C+Kenneth+A%3BPark%2C+Janet&rft.aulast=Shapiro&rft.aufirst=William&rft.date=1983-11-01&rft.volume=34&rft.issue=11&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331978303401103 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Work capacity; Physical therapy; Therapy; Stress; Patients; Exercise; Drugs; Heart diseases DO - http://dx.doi.org/10.1177/000331978303401103 ER - TY - JOUR T1 - Suicide among Older People: Projections for the Future AN - 61071240; 84O0344 AB - Guided by recent demographic analyses of birth cohort effects, the relationship between cohort size & longitudinal suicide rates is demonstrated, with reference to four particular cohorts that have entered adulthood at various periods throughout the present century. Combining this perspective with a look at projected population increases among older age groups, estimates are made of the scope of the problem of suicide among older people, which is likely to be encountered during the early decades of the next century. 2 Tables, 2 Figures, 12 References. HA. JF - Suicide and Life-Threatening Behavior AU - Haas, Ann Pollinger AU - Hendin, Herbert AD - Center Psychosocial Studies Veterans Administration Medical Center, Montrose NY 10458 Y1 - 1983/10// PY - 1983 DA - October 1983 SP - 147 EP - 154 VL - 13 IS - 3 SN - 0363-0234, 0363-0234 KW - longitudinal suicide rates KW - birth cohort size KW - older persons KW - demographic analysis, future projection KW - Cohort/Cohorts KW - Elder/Elders/Elderly KW - Suicide/Suicides/Suicidal KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61071240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Suicide+among+Older+People%3A+Projections+for+the+Future&rft.au=Haas%2C+Ann+Pollinger%3BHendin%2C+Herbert&rft.aulast=Haas&rft.aufirst=Ann&rft.date=1983-10-01&rft.volume=13&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide/Suicides/Suicidal; Cohort/Cohorts; Elder/Elders/Elderly ER - TY - JOUR T1 - Functional performance of the knee after intraarticular anesthesia AN - 20079063; 10092651 AB - Ten healthy young volunteers underwent gait analysis and tests of knee joint position sense. Gait analysis included determination of stride characteristics (veloc ity, cadence, gait cycle, stride length, and single limb support time), force plate analysis, and motion analysis of the knee. The tests of joint position sense examined the ability of the subject to reproduce passive position ing of the knee and the ability to detect change in angle at the knee joint. In a double-blind manner, 10 cc of sterile fluid were injected into the left knee of each volunteer. Five received 2% lidocaine, the other five received sterile saline. All tests were then repeated. No statistically significant difference was observed in any measurement before and after injection in either test group. It is concluded that intraarticular anesthesia has no effect on gait pattern or joint proprioception as measured.Intraarticular local anesthesia is used in sports medi cine to alleviate pain during arthroscopy of the knee under local anesthetic. The possibility of permitting damage in the early postoperative period due to loss of joint position sense is addressed in this paper. The results of this study suggest that injection of local anesthetic into a joint with an intact joint capsule does not compromise joint position sense as measured in this study. Furthermore, no change in gait parameters was observed in the functional task of ambulation. It must be noted that no conclusions regarding the loss of pain sensation can be made from the results of this study. Also, no conclusions regarding competitive ac tivity can be drawn from this study. JF - American Journal of Sports Medicine AU - Barrack, Robert L AU - Skinner, Harry B AU - Brunet, Michael E AU - Haddad, Ray J AD - Department of Orthopaedic Surgery, Tulane University, School of Medicine, New Orleans, Louisiana, Veterans Administration Hospital, New Orleans, Louisiana Y1 - 1983/07// PY - 1983 DA - Jul 1983 SP - 258 EP - 261 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 4 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Measurement KW - Anesthesia KW - Analysis KW - Knees KW - Pain KW - Volunteerism KW - Gait KW - Injections KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20079063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Functional+performance+of+the+knee+after+intraarticular+anesthesia&rft.au=Barrack%2C+Robert+L%3BSkinner%2C+Harry+B%3BBrunet%2C+Michael+E%3BHaddad%2C+Ray+J&rft.aulast=Barrack&rft.aufirst=Robert&rft.date=1983-07-01&rft.volume=11&rft.issue=4&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658301100414 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Measurement; Anesthesia; Analysis; Knees; Pain; Volunteerism; Injections; Gait; Joints DO - http://dx.doi.org/10.1177/036354658301100414 ER - TY - JOUR T1 - Psychiatric syndromes and psychological symptoms associated with organic heart disease. AN - 80969162; 6400600 JF - Psychiatric medicine AU - Young, L D AD - Psychiatry Service, Wood Veterans Administration Medical Center, Wisconsin. Y1 - 1983/06// PY - 1983 DA - June 1983 SP - 181 EP - 204 VL - 1 IS - 2 SN - 0732-0868, 0732-0868 KW - Anti-Arrhythmia Agents KW - 0 KW - Antihypertensive Agents KW - Index Medicus KW - Endocarditis -- psychology KW - Coronary Artery Disease -- psychology KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Cardiac Surgical Procedures -- psychology KW - Anti-Arrhythmia Agents -- adverse effects KW - Myocardial Infarction -- psychology KW - Heart Valve Diseases -- psychology KW - Angina Pectoris -- psychology KW - Hypertension -- psychology KW - Embolism -- psychology KW - Female KW - Male KW - Affective Symptoms -- etiology KW - Coronary Disease -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80969162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+medicine&rft.atitle=Psychiatric+syndromes+and+psychological+symptoms+associated+with+organic+heart+disease.&rft.au=Young%2C+L+D&rft.aulast=Young&rft.aufirst=L&rft.date=1983-06-01&rft.volume=1&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Psychiatric+medicine&rft.issn=07320868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-04 N1 - Date created - 1987-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drinking Behavior, Personality Factors and High-Risk Driving: A Review and Theoretical Formulation AN - 61041342; 86Q6116 AB - A review of the literature concerned with five broad categories of psychosocial variables contributing to the risk of traffic accidents: (1) demographic characteristics; (2) excessive alcohol use; (3) personality traits; (4) acute states of emotional distress; & (5) driving-related attitudes. A theoretical cognitive-behavioral model is presented in an attempt to integrate the results concerning the influence of these factors, in which deficient coping skills or hostile-aggressive trait disposition, combined with high alcohol use, lead to stress, frustration, decreased self-efficacy, & ultimately to increased covert & overt aggression expressed in driving. Areas for future research are proposed. 1 Figure, 148 References. Modified HA JF - Journal of Studies on Alcohol AU - Donovan, Dennis Michael AU - Marlatt, G Alan AU - Salzberg, Philip M AD - Veterans Administration Medical Center, 4435 Beacon Ave South Seattle WA 98108 Y1 - 1983/05// PY - 1983 DA - May 1983 SP - 395 EP - 428 VL - 44 IS - 3 SN - 0096-882X, 0096-882X KW - high-risk driving KW - personality/demographic factors, alcohol use KW - literature review KW - Alcohol Use KW - Automobiles KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61041342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Drinking+Behavior%2C+Personality+Factors+and+High-Risk+Driving%3A+A+Review+and+Theoretical+Formulation&rft.au=Donovan%2C+Dennis+Michael%3BMarlatt%2C+G+Alan%3BSalzberg%2C+Philip+M&rft.aulast=Donovan&rft.aufirst=Dennis&rft.date=1983-05-01&rft.volume=44&rft.issue=3&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Alcohol Use; Automobiles ER - TY - JOUR T1 - Constitutional Factors Predictive of Alcoholism in a Follow-Up of Delinquent Boys AN - 61038573; 86Q6218 AB - The constitutional, behavioral, & rearing experiences of a group of 200 M juvenile delinquents, originally enrolled between 1939 & 1943 in a residential treatment program & contacted for follow-ups in 1958, 1964, 1973, & 1978, are examined to determine which variables differentiated between alcoholics & nonalcoholics on follow-ups. Of 10 physical constitution variables, 9 medical/psychiatric pathology variables, 7 parental variables, & 4 early environment variables, the single most important variable in a multivariate discriminant analysis was gynemorphy (feminine physique). Nine additional variables are identified as relevant. A discriminant function is developed that correctly classifies 85% of the cases identified as either alcoholic or normal (N= 61). 2 Tables, 8 References. Modified HA JF - Journal of Studies on Alcohol AU - Monnelly, Edward P AU - Hartl, Emil M AU - Elderkin, Roland AD - Veterans Administration Outpatient Clinic, 17 Court St Boston MA 02108 Y1 - 1983/05// PY - 1983 DA - May 1983 SP - 530 EP - 537 VL - 44 IS - 3 SN - 0096-882X, 0096-882X KW - alcoholism, juvenile delinquents KW - physical constitutional/other variables KW - interviews, social agency records KW - longitudinal analysis KW - Juvenile Delinquency KW - Alcoholism KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61038573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Constitutional+Factors+Predictive+of+Alcoholism+in+a+Follow-Up+of+Delinquent+Boys&rft.au=Monnelly%2C+Edward+P%3BHartl%2C+Emil+M%3BElderkin%2C+Roland&rft.aulast=Monnelly&rft.aufirst=Edward&rft.date=1983-05-01&rft.volume=44&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Alcoholism; Juvenile Delinquency ER - TY - JOUR T1 - Survey Analysis of Combat-Related Stress Disorders in Viet Nam Veterans AN - 61098815; 84N8617 AB - Of 1,089 Veterans Administration mental health professionals responding to a survey, most reported that Vietnam veterans were less well-adjusted than veterans of previous wars, largely due to the specific experiences in Vietnam & the lack of support on return home. 1 Table, 10 References. HA. JF - The American Journal of Psychiatry AU - Keane, Terence M AU - Fairbank, John A AD - Veterans Administration Medical Center, 1500 East Woodrow Wilson Dr Jackson MS 39216 Y1 - 1983/03// PY - 1983 DA - March 1983 SP - 348 EP - 350 VL - 140 IS - 3 SN - 0002-953X, 0002-953X KW - Vietnam veterans' combat-related stress disorders KW - survey KW - Veterans Administration mental health professionals KW - Veterans Administration KW - Veteran/Veterans KW - Stress/Stresses KW - Mental health KW - Vietnam/Vietnamese KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61098815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Survey+Analysis+of+Combat-Related+Stress+Disorders+in+Viet+Nam+Veterans&rft.au=Keane%2C+Terence+M%3BFairbank%2C+John+A&rft.aulast=Keane&rft.aufirst=Terence&rft.date=1983-03-01&rft.volume=140&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Vietnam/Vietnamese; Veteran/Veterans; Stress/Stresses; Veterans Administration; Mental health ER - TY - JOUR T1 - Kinematic and electromyographic patterns of Olympic race walkers AN - 20752084; 10092615 AB - The performance of two Olympic race walkers was studied during free-speed, fast, and race walking. Measurements of the stride and temporal components of gait, as well as the simultaneous displacement patterns of the body segments, and the electromyo graphic activity of muscles of the trunk and upper and lower limbs were recorded during the three walking speeds. During the testing, the race walkers achieved an average speed of 12.5 km/hr as compared to the 8.7 km/hr average speed achieved by normal men of the same age during fast walking. Race walking was characterized by an increase in cadence and stride length beyond that of normal controls (in a prior study) during fast walking, with stride lengths averaging 125% of stature during race walking, and 115% dur ing normal fast walking. In the two race walkers the amplitudes of most of the movement patterns of the trunk and upper and lower limbs were exaggerated during race walking as compared to normal controls' fast walking. Several mechanisms were used by the race walkers to minimize the vertical excursion of the center of gravity of the body during race walking. All of the muscles monitored in the race walkers showed an increase in the amplitude of electromyographic activity during race walking as compared to fast walk ing ; duration of muscle activity was also usually in creased during race walking. Several suggestions for prevention of injuries associated with race walking are made. JF - American Journal of Sports Medicine AU - Murray, MPatricia AU - Guten, Gary N AU - Mollinger, Louise A AU - Gardner, Gena M AD - Kinesiology Research Laboratory, Veterans Administration Medical Center, Wood (Milwaukee), Wisconsin, Departments of Anatomy and Orthopaedic Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin Y1 - 1983/03// PY - 1983 DA - Mar 1983 SP - 68 EP - 74 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 2 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Speed KW - Trunk KW - Preventive health KW - Walking KW - Center of gravity KW - Muscles (activity) KW - Performance KW - Sports medicine KW - Olympics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20752084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Kinematic+and+electromyographic+patterns+of+Olympic+race+walkers&rft.au=Murray%2C+MPatricia%3BGuten%2C+Gary+N%3BMollinger%2C+Louise+A%3BGardner%2C+Gena+M&rft.aulast=Murray&rft.aufirst=MPatricia&rft.date=1983-03-01&rft.volume=11&rft.issue=2&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658301100204 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Speed; Trunk; Preventive health; Walking; Center of gravity; Performance; Muscles (activity); Sports medicine; Olympics DO - http://dx.doi.org/10.1177/036354658301100204 ER - TY - JOUR T1 - Mental Health and Native Americans: Responding to the Challenge of the Biopsychosocial Model AN - 61007975; 86Q8782 AB - The mental health needs of Native Americans have long been neglected in the professional psychological & psychiatric literatures. Here described is a Ru, hospital-based community mental health program that utilizes an array of remedial, developmental, & preventive strategies to respond to this population's unique biopsychosocial needs. Since outpatient, outreach, & aftercare programs also play a critical role in a comprehensive mental health program, they are discussed from a general systems theory orientation. From this perspective, the development of treatment & consulting networks is essential to provide a full spectrum of mental health services to Native Americans in Ru areas. 27 References. Modified HA JF - White Cloud Journal of American Indian Mental Health AU - Marburg, Galen Sanford AD - Veterans Administration Outpatient Clinic, 101 State St Springfield MA 01103 Y1 - 1983///0, PY - 1983 DA - 0, 1983 SP - 43 EP - 52 VL - 3 IS - 1 KW - community mental health care, Native American population, biopsychosocial model KW - case study KW - Mental Health KW - Community Mental Health Centers KW - American Indians KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61007975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=White+Cloud+Journal+of+American+Indian+Mental+Health&rft.atitle=Mental+Health+and+Native+Americans%3A+Responding+to+the+Challenge+of+the+Biopsychosocial+Model&rft.au=Marburg%2C+Galen+Sanford&rft.aulast=Marburg&rft.aufirst=Galen&rft.date=1983-01-01&rft.volume=3&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=White+Cloud+Journal+of+American+Indian+Mental+Health&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WJAHDP N1 - SubjectsTermNotLitGenreText - Mental Health; American Indians; Community Mental Health Centers ER - TY - JOUR T1 - Sterilization among American Indian and Chicano Mothers AN - 61002958; 85O5492 AB - As part of a larger study concerning family size & birth control among women from various cultures in the Miami, Fla, area (N not specified), interview & questionnaire data obtained from the Indian & Chicano Rs with 5+ children show that a disproportionate number of Indian women had been surgically sterilized. Cultural differences do not appear to account for this; in general, a history of pregnancy complications correlates with subsequent sterilization. Other factors that may contribute to greater incidence of tubal ligation among Indian women are explored. 4 Tables, 17 References. Modified HA. JF - International Quarterly of Community Health and Education AU - Hunter, Kathleen I AU - Linn, Margaret W AU - Stein, Shayna R AD - Veterans Administration Medical Center, Miami FL 33152 Y1 - 1983 PY - 1983 DA - 1983 SP - 343 EP - 352 VL - 4 IS - 4 SN - 0272-684X, 0272-684X KW - female sterilization KW - American Indian/Chicano mothers KW - questionnaires, interviews KW - Miami, Florida KW - *Sterilization KW - *Mother/Mothers/Motherhood/ Mothering KW - *United States/US KW - *Chicano/Chicanos KW - *Society, The, of KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61002958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Quarterly+of+Community+Health+and+Education&rft.atitle=Sterilization+among+American+Indian+and+Chicano+Mothers&rft.au=Hunter%2C+Kathleen+I%3BLinn%2C+Margaret+W%3BStein%2C+Shayna+R&rft.aulast=Hunter&rft.aufirst=Kathleen&rft.date=1983-01-01&rft.volume=4&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=International+Quarterly+of+Community+Health+and+Education&rft.issn=0272684X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2011-12-15 N1 - CODEN - IQCEDN N1 - SubjectsTermNotLitGenreText - *Mother/Mothers/Motherhood/ Mothering; *Sterilization; *Chicano/Chicanos; *Society, The, of; *United States/US ER - TY - JOUR T1 - Persistence, movement and decontamination studies of TCDD in storage sites massively contaminated with phenoxy herbicides AN - 13856666; S198411591 AB - In 1977, the U.S. Air Force disposed of very large amounts of the weedkiller, Herbicide Orange, by high-temperature incineration at sea. Subsequently, a detailed programme was carried out monitoring and reclaiming the sites on land where the weedkiller had been stored prior to disposal; details are given of the development of the monitoring procedure, and results are tabulated. JF - Chemosphere AU - Young, AL AU - Cairney, W J AU - Thalken, CE AD - Veterans Administration, Washington, D.C. Y1 - 1983 PY - 1983 DA - 1983 SP - 713 EP - 726 VL - 12 IS - 4/5 SN - 0045-6535, 0045-6535 KW - Sea water (see also marine -----) KW - Tetrachlorodibenzo-p-dioxin KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13856666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Persistence%2C+movement+and+decontamination+studies+of+TCDD+in+storage+sites+massively+contaminated+with+phenoxy+herbicides&rft.au=Young%2C+AL%3BCairney%2C+W+J%3BThalken%2C+CE&rft.aulast=Young&rft.aufirst=AL&rft.date=1983-01-01&rft.volume=12&rft.issue=4%2F5&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - A Behavioral Economic Approach to the Defense Mechanisms: Freud's Energy Theory Revisited AN - 61102275; 83N0769 AB - Sigmund Freud developed an economic analysis of motivational conflict, but defined its dimensions ambiguously. He described motives, called impulses, which oppose a person's own long-range interest, & which might both create & be created by processes called defense mechanisms. He said that the desire to avoid unpleasant perceptions leads to censorship of consciousness, a defensive process; however, this censorship distorts motivation & creates impulses, necessitating impulse-control processes, also termed defensive. Recent experiments on delayed reward have shown the importance of distinguishing between these two processes, & have suggested that the need for impulse control may be independent of the tendency to censor conscious perception. Impulses may arise simply because the power of reward declines in a hyperbolic curve as a funcion of delay; ie, a smaller reward can be preferred temporarily to larger alternatives not immediately available. Defense mechanisms designed to prevent impulses must forestall this temporary change of preference by precommitting future behavior. Four precommitment strategies are described -- extrapsychic constraints, attention control, emotion control, & private side bets -- all of which include mechanisms described by psychoanalysts. The findings of basic research in motivation support & clarify many metapsychological constructs of the psychoanalysts. In particular, this approach carries on Freud's effort to define separate interests within the person, so that some laws of interpersonal bargaining can be applied to transactions among one person's internal interests. 2 Figures. Modified AA. JF - Social Science Information/Information sur les Sciences Sociales AU - Ainslie, George AD - Veterans Administration Medical Center, Coatesville PA 19320 Y1 - 1982/12// PY - 1982 DA - December 1982 SP - 735 EP - 779 VL - 21 IS - 6 SN - 0539-0184, 0539-0184 KW - defense mechanisms, behavioral economic approach, Sigmund Freud's motivational conflict theory reanalyzed KW - Motive/Motives/Motivation/ Motivational KW - Mechanism/Mechanisms KW - Economic/Economics/Economical KW - Behavior/Behavioral KW - Freud, Sigmund/Freudian/Freudianism KW - Defense/Defenses KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61102275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+Information%2FInformation+sur+les+Sciences+Sociales&rft.atitle=A+Behavioral+Economic+Approach+to+the+Defense+Mechanisms%3A+Freud%27s+Energy+Theory+Revisited&rft.au=Ainslie%2C+George&rft.aulast=Ainslie&rft.aufirst=George&rft.date=1982-12-01&rft.volume=21&rft.issue=6&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Social+Science+Information%2FInformation+sur+les+Sciences+Sociales&rft.issn=05390184&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCIBL N1 - SubjectsTermNotLitGenreText - Defense/Defenses; Mechanism/Mechanisms; Behavior/Behavioral; Economic/Economics/Economical; Freud, Sigmund/Freudian/Freudianism; Motive/Motives/Motivation/ Motivational ER - TY - JOUR T1 - The cochlear nuclei revisited. AN - 85206817; pmid-10994424 AB - The cochlear nuclei (CN) in man consist of the dorsal (DCN), superior ventral (SVCN), and inferior ventral (IVCN). The CN is located on the dorsolateral surface of the brain stem at the junction of the medulla with the pons. The DCN curves over the inferior cerebellar peduncle and forms part of its dorsolateral surface. The IVCN is found beneath the lateral portion of the DCN. The SVCN is for the most part covered by the inferior portion of the middle cerebellar peduncle. Of five types of nerve cells found in the CN in man, spheroid cells appear especially in the SVCN. They are the second-order neurons of the main ascending neural auditory pathway. Their injury forms the basis for hearing loss of central type. The SVCN can be mapped into estimated frequency strata progressing from low frequencies ventral to high frequencies dorsal. Spheroid cells are susceptible to injury notably by anoxia and especially centering around an estimated 4,000 Hz frequency level in the SVCN. The pattern of injury of spheroid cells can be displayed in comparison with audiometric tracing on a standard audiogram chart. JF - Otolaryngology--Head and Neck Surgery AU - Dublin, W B AD - Laboratory of Auditory Pathology, Veterans Administration Medical Center, Martinez, Calif., USA. PY - 1982 SP - 744 EP - 760 VL - 90 IS - 6 SN - 0194-5998, 0194-5998 KW - Brain Mapping KW - Hearing Loss, Central KW - Human KW - Neurons KW - Pitch Perception KW - Cochlear Nucleus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85206817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=The+cochlear+nuclei+revisited.&rft.au=Dublin%2C+W+B&rft.aulast=Dublin&rft.aufirst=W&rft.date=1982-11-01&rft.volume=90&rft.issue=6&rft.spage=744&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Acetate Metabolism During Hemodialysis AN - 1328508802; 17397218 AB - We infused acetate into normal human subjects and performed kinetic analysis of the plasma and urine values obtained before, during, and after the infusion. The data were best fitted by a first-order elimination process with a mean metabolic clearance rate of 2.3 L/min. Gotch and Sargent had previously suggested that during dialysis, acetate metabolism was zero order. We performed kinetic modeling of acetate concentrations during dialysis. The data were best fitted to a Michaelis-Menton model (i.e., first-order metabolism at low concentrations and saturated at high concentrations). The mean Km for acetate in the dialysis patients was 8.5 mM and the mean Vmax was 18 mmol/min. Patients with a Vmax less than 7 mmol/min usually had a fall in plasma bicarbonate during dialysis while patients with a Vmax greater than 14 mmol/min usually had a rise in bicarbonate during dialysis. It is concluded that during high-surface-area dialysis, the capacity for acetate metabolism will affect acid-base homeostasis. Kinetic modeling will be useful to define acetate-intolerant patients and may be used to predict patients who will benefit from bicarbonate hemodialysis. JF - Artificial Organs AU - Weiner, Michael W AD - Veterans Administration Medical Center and University of California, San Francisco, San Francisco, California, U.S.A Y1 - 1982/11// PY - 1982 DA - Nov 1982 SP - 370 EP - 377 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 6 IS - 4 SN - 0160-564X, 0160-564X KW - Biotechnology and Bioengineering Abstracts KW - Acetic acid KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1328508802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Organs&rft.atitle=Acetate+Metabolism+During+Hemodialysis&rft.au=Weiner%2C+Michael+W&rft.aulast=Weiner&rft.aufirst=Michael&rft.date=1982-11-01&rft.volume=6&rft.issue=4&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Artificial+Organs&rft.issn=0160564X&rft_id=info:doi/10.1111%2Fj.1525-1594.1982.tb04129.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Acetic acid DO - http://dx.doi.org/10.1111/j.1525-1594.1982.tb04129.x ER - TY - JOUR T1 - Parole/Probation Therapy Group: Melding Mental Health and County Corrections AN - 61480877; 198401750 AB - A nontraditional outpatient group program was instituted to improve services to parole/probation clients (N = 52). The group uses various techniques to optimize potential for client success. A one-year study indicates the group is cost-effective, may improve client attendance, & has improved relations between parole/probation & mental health staffs. 3 Tables, 1 Reference. Modified HA. JF - Journal of Offender Counseling, Services and Rehabilitation AU - Ryan, Timothy T AU - Bachus, Charles AD - Veterans Administration Medical Center, Lyons NJ 07939 Y1 - 1982/10// PY - 1982 DA - October 1982 SP - 63 EP - 67 VL - 7 IS - 1 KW - parole/probation therapy group KW - melding mental health/county corrections KW - Probation/Probationer/Probationers KW - Parole/Paroled/Parolee/Parolees KW - Therapy/Therapeutic KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61480877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Offender+Counseling%2C+Services+and+Rehabilitation&rft.atitle=Parole%2FProbation+Therapy+Group%3A+Melding+Mental+Health+and+County+Corrections&rft.au=Ryan%2C+Timothy+T%3BBachus%2C+Charles&rft.aulast=Ryan&rft.aufirst=Timothy&rft.date=1982-10-01&rft.volume=7&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+Offender+Counseling%2C+Services+and+Rehabilitation&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Therapy/Therapeutic; Probation/Probationer/Probationers; Parole/Paroled/Parolee/Parolees ER - TY - JOUR T1 - Incidence of Wife-Battering in Male Psychiatric Hospital Patients: Are Special Treatment Programs Needed? AN - 61042063; 83N5334 AB - Staff psychologists interviewed 137 M admissions to the psychiatric & chemical dependency wards of the St. Cloud (Minn) Veterans Administration Medical Center to estimate the incidence of physical abuse toward wives/partners. Among the 101 Ss who had lived with a woman, physical abuse was reported in 54 cases. However, incidents rated "serious" by 50+% of a panel of 12 judges had occurred in only 23 of those cases overall, & only 6 within the previous year. Since this incidence represents only 4% of the sample, the need for special treatment programs for batterers is probably limited to a small minority of M psychiatric hospital patients. 2 Tables. Modified HA. JF - Psychological Reports AU - Watson, Charles G AU - Rosenberg, Angela M AU - Petrik, Norman AD - Veterans Administration Medical Center, Saint Cloud MN 56301 Y1 - 1982/10// PY - 1982 DA - October 1982 SP - 563 EP - 566 VL - 51 IS - 2 KW - wife-battering incidence, male psychiatric hospital patients, special treatment programs consideration KW - interviews KW - Veterans Administration Medical Center KW - Patient/Patients KW - Psychiatry/Psychiatric KW - Male/Males (see also Man) KW - Wife/Wives KW - Battered KW - Treatment KW - Hospital/Hospitals KW - Program/Programs/Programmer/ Programmers KW - article KW - 2858: studies in violence; studies in violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61042063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Incidence+of+Wife-Battering+in+Male+Psychiatric+Hospital+Patients%3A+Are+Special+Treatment+Programs+Needed%3F&rft.au=Watson%2C+Charles+G%3BRosenberg%2C+Angela+M%3BPetrik%2C+Norman&rft.aulast=Watson&rft.aufirst=Charles&rft.date=1982-10-01&rft.volume=51&rft.issue=2&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Battered; Wife/Wives; Male/Males (see also Man); Hospital/Hospitals; Psychiatry/Psychiatric; Patient/Patients; Treatment; Program/Programs/Programmer/ Programmers ER - TY - JOUR T1 - Role of cyclic adenosine monophosphate in amylase release from dissociated rat pancreatic acini AN - 1773824296; 21243638 AB - 1. The effect of octapeptide of cholecystokinin-pancreozymin (CCK8), bethanechol, cholera toxin, glucagon and vasoactive intestinal polypeptide (VIP) on amylase secretion and lactic dehydrogenase (LDH) release from isolated rat pancreatic acini was studied. 2. In isolated rat pancreatic acini, in the absence of theophylline in the medium, amylase secretion was increased by 65-78% with 10-7 and 10-6 M-cholera toxin. In the presence of theophylline, amylase secretion was increased by 43-56% with 10-7 and 10-6 M-cholera toxin following a 90 min incubation. No effect was observed in the presence of theophylline at 30 and 60 min. The effect of cholera toxin was potentiated by CCK8 at 60 and 90 min. 3. In the absence of theophylline in the medium, amylase secretion was increased by 81-118% with 10-5 and 10-4 M-glucagon and 86% with 10-6 M-VIP at 60 min. In the presence of theophylline in the medium, amylase secretion was increased by 53-246% with 10-9 to 10-6 M-glucagon and 111-158% with 10-7 and 10-6 M-VIP respectively. The effect of glucagon and VIP was potentiated by CCK8. 4. Potentiation of the rate of amylase release due to glucagon (10-5 M) and VIP (10-6 M) occurred during the first 15 min of incubation. 5. Release of LDH was not increased by any of these agents. 6. It is concluded that cyclic AMP rise (due to cholera toxin, glucagon and VIP effect) increased amylase secretion from rat pancreatic acinar cells. This effect is less marked than in the guinea-pig pancreas and is potentiated by agents mobilizing cellular Ca2+ (CCK8 and bethanechol). 7. These data indicate species-specific variation in the action of cyclic AMP in the pancreas. JF - Journal of Physiology (London) AU - Singh, Manjit AD - Pancreatic Research Laboratory, Medical Research Service, Veterans Administration Medical Centre (Downtown Division), Augusta, GA 30910, U.S.A. Y1 - 1982/10/01/ PY - 1982 DA - 1982 Oct 01 SP - 547 EP - 555 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 331 IS - 1 SN - 0022-3751, 0022-3751 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773824296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physiology+%28London%29&rft.atitle=Role+of+cyclic+adenosine+monophosphate+in+amylase+release+from+dissociated+rat+pancreatic+acini&rft.au=Singh%2C+Manjit&rft.aulast=Singh&rft.aufirst=Manjit&rft.date=1982-10-01&rft.volume=331&rft.issue=1&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physiology+%28London%29&rft.issn=00223751&rft_id=info:doi/10.1113%2Fjphysiol.1982.sp014390 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Document feature - figure 0 N1 - Last updated - 2016-03-17 DO - http://dx.doi.org/10.1113/jphysiol.1982.sp014390 ER - TY - JOUR T1 - Single Parent Families: A Look at Families of Mothers and Children AN - 61025072; 84N8510 AB - The research literature on single parent families of mothers & children is reviewed. Although the number & % of single parent families have increased significantly since the 1960s, a deviance or pathology perspective has permeated much of the research on them. Three other major problems with previous research are reviewed: focus on the individual rather than on the family, with the attending assumption that all single parent families are alike; the lack of examination of the family's relationship to its social environment -- both macro & micro; & the assumption of an absent father. A review of research that attempts to avoid or correct these problems is offered. It is concluded that single parent families must be studied as families that relate both to large-scale institutions & smaller social networks; that they may vary widely in their organization; & that the so-called absent father often continues to play an important role within the family. 122 References. Modified AA. JF - Marriage and Family Review AU - Gongla, Patricia A AD - Veterans Administration Medical Center, Brentwood 11301 Wilshire Blvd Los Angeles CA 90073 Y1 - 1982/07// PY - 1982 DA - July 1982 SP - 5 EP - 27 VL - 5 IS - 2 SN - 0149-4929, 0149-4929 KW - single parent families, mothers/children KW - literature review KW - Child/Children/Childhood KW - Mother/Mothers/Motherhood/ Mothering KW - Family/Families KW - Parent/Parents/Parental KW - Single KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61025072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marriage+and+Family+Review&rft.atitle=Single+Parent+Families%3A+A+Look+at+Families+of+Mothers+and+Children&rft.au=Gongla%2C+Patricia+A&rft.aulast=Gongla&rft.aufirst=Patricia&rft.date=1982-07-01&rft.volume=5&rft.issue=2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Marriage+and+Family+Review&rft.issn=01494929&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - MFARDJ N1 - SubjectsTermNotLitGenreText - Single; Parent/Parents/Parental; Family/Families; Mother/Mothers/Motherhood/ Mothering; Child/Children/Childhood ER - TY - JOUR T1 - The Medial Tibial Stress Syndrome. A Cause of Shin Splints AN - 20050117; 10092555 AB - The medial tibial stress syndrome is a symptom com plex seen in athletes who complain of exercise-in duced pain along the distal posterior-medial aspect of the tibia. Intramuscular pressures within the posterior compartments of the leg were measured in 12 patients with this disorder. These pressures were not elevated and therefore this syndrome is not a compartment syndrome. Available information suggests that the medial tibial stress syndrome most likely represents a periostitis at this location of the leg. JF - American Journal of Sports Medicine AU - Mubarak, Scott J AU - Gould, Robert N AU - Yu Fon Lee AU - Schmidt, Donald A AU - Hargens, Alan R AD - Department of Surgery (Orthopaedics), Veterans Administration and University of California Medical Centers, San Diego, California Y1 - 1982/07// PY - 1982 DA - Jul 1982 SP - 201 EP - 205 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 10 IS - 4 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Measurement KW - Stress KW - Legs KW - Patients KW - Pain KW - Sports medicine KW - Compartment syndrome KW - Athletes KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20050117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=The+Medial+Tibial+Stress+Syndrome.+A+Cause+of+Shin+Splints&rft.au=Mubarak%2C+Scott+J%3BGould%2C+Robert+N%3BYu+Fon+Lee%3BSchmidt%2C+Donald+A%3BHargens%2C+Alan+R&rft.aulast=Mubarak&rft.aufirst=Scott&rft.date=1982-07-01&rft.volume=10&rft.issue=4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658201000402 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Measurement; Stress; Pain; Patients; Legs; Compartment syndrome; Sports medicine; Athletes DO - http://dx.doi.org/10.1177/036354658201000402 ER - TY - JOUR T1 - Isolation of Pittsburgh Pneumonia Agent from a Hospital Shower AN - 19242458; 8206891 AB - The isolation of Tatlockia (Legionella) micdadei, the Pittsburgh pneumonia agent (PPA), from sediment obtained from a hospital shower is reported. Sediment was scraped with a sterile Dacron swab from the shower heads and mixing valves of 25 showers on 10 wards at the Pittsburgh Veterans Administration Medical Center. All recovered sediment was suspended in buffered yeast extract broth. Cultures were prepared and incubated aerobically and observed daily. Whereas several of the samples contained L. pneumophila, one contained a gram-negative rod which grew on the supplemented yeast extract agars but not on sheep blood agar. On the dye-containing buffered charcoal-yeast extract agar it grew as a blue-grey, nonfluorescing colony, typical of T. micdadei. It is suggested that the isolation of this organism from shower heads may be clinically significant because it provides further evidence that a water associated reservoir exists within the hospital. In addition, since an aerosol is produced by showering , this is a plausible source for the transmission of an organism producing pneumonia. (Baker-FRC) JF - Applied and Environmental Microbiology Vol 43, No 3, p 725-726, March, 1982. 15 Ref. AU - Brown, A AU - Yu, V L AU - Magnussen, M H AU - Vickers, R M AU - Garrity, G M AD - Veterans Administration Medical Center Pittsburgh, PA Y1 - 1982/03// PY - 1982 DA - Mar 1982 KW - Water Resources Abstracts KW - Aerosols KW - Human disease KW - Bacteria KW - Tatlockia KW - Pittsburgh pneumonia agent KW - Microorganisms KW - Air pollution KW - Fallout KW - Sediment KW - Pneumonia KW - Legionella KW - Public health KW - Water pollution sources KW - Epidemiology KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19242458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Isolation+of+Pittsburgh+Pneumonia+Agent+from+a+Hospital+Shower&rft.au=Brown%2C+A%3BYu%2C+V+L%3BMagnussen%2C+M+H%3BVickers%2C+R+M%3BGarrity%2C+G+M&rft.aulast=Brown&rft.aufirst=A&rft.date=1982-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Social Support and Well-Being: Implications for Prevention Programs AN - 61632878; 198401374 AB - Various prevention programs have assumed that social support has health-promotive & health-protective effects. Although numerous studies have examined the relationship between social support & well-being, the findings are heterogeneous & complex. This research is reviewed as a database for planning & evaluating prevention programs. To organize the review, a model of stress, support, & well-being is presented that distinguishes among several mechanisms by which support may affect well-being. Research on each of these mechanisms is considered with regard to: the direct effects of support on functioning through its influence of exposure to environmental stressors; & the interactive effects of social supports in buffering the individual from the maladaptive effects of stress. Several implications of the research are addressed that should be considered in designing & evaluating prevention programs. 1 Table, 74 References. Modified HA. JF - The Journal of Primary Prevention AU - Mitchell, Roger E AU - Billings, Andrew G AU - Moos, Rudolf H AD - Veterans Administration Medical Center Stanford U, Palo Alto CA 94305 Y1 - 1982/01// PY - 1982 DA - January 1982 SP - 77 EP - 98 VL - 3 IS - 2 SN - 0278-095X, 0278-095X KW - well-being KW - social support KW - implications for prevention programs KW - Social support KW - Well-being KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61632878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Primary+Prevention&rft.atitle=Social+Support+and+Well-Being%3A+Implications+for+Prevention+Programs&rft.au=Mitchell%2C+Roger+E%3BBillings%2C+Andrew+G%3BMoos%2C+Rudolf+H&rft.aulast=Mitchell&rft.aufirst=Roger&rft.date=1982-01-01&rft.volume=3&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Primary+Prevention&rft.issn=0278095X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Well-being; Social support ER - TY - JOUR T1 - A Group Awaiting Death: The Social Systems Perspective on a Naturally Occurring Group Situation AN - 61559848; 198201597 AB - The decline & imminent death of an individual in a hospital's intensive care unit led to the creation of a transient group composed of family & friends. The dynamics of this tragic group are explored using the concepts provided by social systems theory. Ambiguity of the task structure & its inherent frustrations, fluidity of leadership & power, & failure of a utopian defense are all discussed as contributors to subsequent dissension & splitting. The social systems perspective provides a useful tool for understanding this naturally occurring group situation. 1 Table. HA. JF - Omega AU - Starker, Steven AU - Starker, Joan E AD - Veterans Administration Medical Center, Portland OR 97207 Y1 - 1982 PY - 1982 DA - 1982 SP - 79 EP - 89 VL - 13 IS - 1 SN - 0030-2228, 0030-2228 KW - dying patient/family, friends, naturally occurring group situation, social systems perspective KW - *Friend/Friends/Friendship KW - *Social system/Social systems KW - *Family/Families KW - *Patient/Patients KW - *Group/Groups/Grouping/Groupism KW - *Death/Deaths (see also Mortality, Dying) KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61559848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Omega&rft.atitle=A+Group+Awaiting+Death%3A+The+Social+Systems+Perspective+on+a+Naturally+Occurring+Group+Situation&rft.au=Starker%2C+Steven%3BStarker%2C+Joan+E&rft.aulast=Starker&rft.aufirst=Steven&rft.date=1982-01-01&rft.volume=13&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Omega&rft.issn=00302228&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2012-02-15 N1 - SubjectsTermNotLitGenreText - *Patient/Patients; *Death/Deaths (see also Mortality, Dying); *Group/Groups/Grouping/Groupism; *Family/Families; *Friend/Friends/Friendship; *Social system/Social systems ER - TY - JOUR T1 - Prostaglandin and acyl chain effects on glutamate dehydrogenase activity. AN - 15530733; 368762 AB - Prostaglandins A sub(1) (PGA sub(1)), A sub(2), B sub(1), B sub(2), E sub(1), E sub(2), F sub(1 alpha ), F sub(2 alpha ), and 19 esterified natural fatty acids were tested as effectors of beef liver glutamate dehydrogenase (L-glutamate: NAD(P) super(+) oxidoreductase (deaminating, EC 1.4.1.3). All prostaglandins tested are found to activate the enzyme initially, but only PAG sub(2)>PGB sub(2) greater than or equal to PAG sub(1) cause a subsequent time-dependent loss (not inhibition) of NADH oxidation activity. Both PGA sub(1) and PGA sub(2) desensitize glutamate dehydrogenase to allosteric activation by ADP, whereas PGA sub(2) and PGB sub(2) desensitize to allosteric inactivation by GTP. Preincubation of enzyme with diethylstilbestrol prevents the initial activation by the PG. Of the methyl esters, only prostaglandin precursors inactivated the enzyme. Simultaneous desensitization to the ADP and GTP allosteric effects resulted. Multiple esterification to glycerol or phospholipids enhanced the action of linolenoyl and diminished the action of linolenoyl chains. JF - Lipids AU - Shafer, P T AU - Fiskin, A M AD - Med. Res. Serv., Veterans Administration Med. Cent., 4801 Linwood Blvd., Kansas City, MO 64128, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 297 EP - 306 VL - 17 IS - 4 SN - 0024-4201, 0024-4201 KW - activity KW - cattle KW - effects on KW - fatty acids KW - glutamate dehydrogenase (NAD(P) super(+)) KW - liver KW - prostaglandins KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15530733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Prostaglandin+and+acyl+chain+effects+on+glutamate+dehydrogenase+activity.&rft.au=Shafer%2C+P+T%3BFiskin%2C+A+M&rft.aulast=Shafer&rft.aufirst=P&rft.date=1982-01-01&rft.volume=17&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - alpha -Ketoglutaric Acid: Solution Structure and the Active Form for Reductive Amination by Bovine Liver Glutamate Dehydrogenase. AN - 15440287; 244416 AB - A study of the various solution forms of alpha -ketoglutaric acid using UV absorption spectrophotometry and super(13)C NMR spectroscopy shows that at neutral pH alpha -ketoglutarate exists predominantly as the keto form with about 7% hydrated form (gem -diol) and a small amount of cyclic form. Protonation of the gamma -carboxylate group increases the amount of cyclic form to 20% with very little increases in the amount of gem -diol. Protonation of the alpha -carboxylate increases the amount of cyclic form to 30% and the amount of gem -diol to 35%. The pH and temperature dependence of the super(13)CNMR line widths indicated that the interconversion of keto and cyclic forms is extremely rapid. The rate of interconversion of keto and gem -diol forms was studied spectrophotometrically at various temperatures, buffers, and pH values and by varying the total concentration of alpha -ketoglutarate. The hydration reaction of alpha -ketoglutarate is not catalyzed by bovine liver glutamate dehydrogenase (E) or by the E-NADPH complex. The enzyme uses the keto form of alpha -ketoglutarate as the substrate. The gem -diol form is not itself a substance but becomes converted to the keto form with a half-life of about 0.3 min at 15 degree C in 0.1 M potassium phosphate buffer (pH 7.6). JF - Biochemistry (Washington) AU - Fisher, H F AU - Viswanathan, T S AU - Johnson, R E AD - Lab. Mol. Biochem., Veterans Administration Med. Cent., Kansas City, MO 64128, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 339 EP - 339,345 VL - 21 IS - 2 SN - 0006-2960, 0006-2960 KW - cattle KW - glutamate dehydrogenase KW - liver KW - substrate specificity KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15440287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=alpha+-Ketoglutaric+Acid%3A+Solution+Structure+and+the+Active+Form+for+Reductive+Amination+by+Bovine+Liver+Glutamate+Dehydrogenase.&rft.au=Fisher%2C+H+F%3BViswanathan%2C+T+S%3BJohnson%2C+R+E&rft.aulast=Fisher&rft.aufirst=H&rft.date=1982-01-01&rft.volume=21&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Campylobacter Enteritis Associated With a Healthy Cat. AN - 15419849; 240827 AB - In The short time since Campylobacter jejuni has become recognized as a significant enteric pathogen of humans, information on the epidemiology of infection has been increasing rapidly. Although direct contact with infected animals or consumption of contaminated water or foods of animal origin are generally suspected as being the important modes of transmission, in only the minority of cases can this be documented. Recent work has implicated contact with infected household pets as one avenue of transmission. The pets involved in such cases were puppies and kittens with diarrhea who were shedding C. jejuni . The authors now report a case of Campylobacter enteritis that occurred in association with infection in an apparently healthy adult cat. JF - Journal of the American Medical Association AU - Blaser, MJ AU - Weiss, SH AU - Barrett, T J AD - Infectious Dis. Sec. (III-L), Veterans Administration Med. Cent., 1055 Clermont St, Denver, CO 80220, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 816 VL - 247 IS - 6 SN - 0098-7484, 0098-7484 KW - subsp.jejuni KW - cats KW - Microbiology Abstracts B: Bacteriology KW - enteritis KW - case reports KW - Campylobacter fetus KW - J 02862:Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15419849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Campylobacter+Enteritis+Associated+With+a+Healthy+Cat.&rft.au=Blaser%2C+MJ%3BWeiss%2C+SH%3BBarrett%2C+T+J&rft.aulast=Blaser&rft.aufirst=MJ&rft.date=1982-01-01&rft.volume=247&rft.issue=6&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Campylobacter fetus; enteritis; case reports ER - TY - JOUR T1 - Ubiquitousness of Legionella pneumophila in the water supply of a hospital with endemic Legionnaires' disease AN - 13874310; 198203906 AB - The reasons for outbreaks of Legionnaires' disease in a veterans' hospital at Pittsburgh, U.S.A. were studied. The conditions at the sites of the outbreaks (taps, showers, wards), a survey of the entire hospital, monthly surveillance of selected sites, specimen collection and preparation and screening of suspected isolates, are described. Legionella pneumophila was readily isolated from the environment of patients with the disease and the serogroup 1 is common to patients and sites. It occurs everywhere in the hospital's water system, and its occurrence can be correlated with the frequency of outbreaks of the disease. The organism is present in highest concentrations in sediments of taps, showers and water tanks. A scenario for entry of the organisms into the water supply, its concentration and subsequent dislodgement at various points and its transmission to patients, is proposed. JF - New England Journal of Medicine AU - Stout, J AU - Yu, V L AU - Vickers, R M AU - Zuravleff, J AU - Best, M AU - Brown, A AU - Yee, R B AU - Wadowsky, R AD - Veterans Administration Medical Center, Pittsburgh Y1 - 1982 PY - 1982 DA - 1982 SP - 466 EP - 468 VL - 306 IS - 8 SN - 0028-4793, 0028-4793 KW - Diseases (see also individual groups below) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13874310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Ubiquitousness+of+Legionella+pneumophila+in+the+water+supply+of+a+hospital+with+endemic+Legionnaires%27+disease&rft.au=Stout%2C+J%3BYu%2C+V+L%3BVickers%2C+R+M%3BZuravleff%2C+J%3BBest%2C+M%3BBrown%2C+A%3BYee%2C+R+B%3BWadowsky%2C+R&rft.aulast=Stout&rft.aufirst=J&rft.date=1982-01-01&rft.volume=306&rft.issue=8&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Efficacy of ozone in eradication of Legionella pneumophila from hospital plumbing fixtures AN - 13862080; 198301112 AB - Studies are reported on the feasibility of using ozone to eradicate Legionella pneumophila from plumbing fixtures in a hospital. Although ozone eradicated the bacterium, it was also eradicated from control fixtures treated with non-ozonated water; this is attributed to a mechanical flushing effect and to an unexpected increase in the chlorine content of the water supply. JF - Applied and Environmental Microbiology AU - Edelstein, PH AU - Whittaker, R E AU - Kreiling, R L AU - Howell, CL AD - Veterans Administration Wadsworth Medical Center, Los Angeles Y1 - 1982 PY - 1982 DA - 1982 SP - 1330 EP - 1334 VL - 44 IS - 6 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13862080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Efficacy+of+ozone+in+eradication+of+Legionella+pneumophila+from+hospital+plumbing+fixtures&rft.au=Edelstein%2C+PH%3BWhittaker%2C+R+E%3BKreiling%2C+R+L%3BHowell%2C+CL&rft.aulast=Edelstein&rft.aufirst=PH&rft.date=1982-01-01&rft.volume=44&rft.issue=6&rft.spage=1330&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The Dynamics, Implications and Treatment of Extramarital Sexual Relationships for the Family Therapist AN - 61585768; 198400564 AB - The family therapist should be aware that extramarital relationships can exist in all treatment situations. Uncomfortable feelings about the subject, in both the couple & the therapist, have to be faced. Cooperation, either on a covert or overt level, is needed to keep infidelity operating in a family system. Intervention techniques are more direct when the focus of treatment is the marriage & more caution is indicated when a child or psychiatric symptoms are the presenting problems. Finally, for a small segment of the population able to compartmentalize between sexual & emotional fidelity, extramarital relationships may be a healthy alternative to traditional marriage. 22 References. HA. JF - Journal of Marital and Family Therapy AU - Elbaum, Phillip L AD - Veterans Administration Hospital, Hines IL 60141 Y1 - 1981/10// PY - 1981 DA - October 1981 SP - 489 EP - 495 VL - 7 IS - 4 SN - 0194-472X, 0194-472X KW - extramarital sexual relationships dynamics/implications/treatment, family therapist KW - Therapist/Therapists KW - Sex/Sexes/Sexism/Sexist/Sexists KW - Family/Families KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61585768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marital+and+Family+Therapy&rft.atitle=The+Dynamics%2C+Implications+and+Treatment+of+Extramarital+Sexual+Relationships+for+the+Family+Therapist&rft.au=Elbaum%2C+Phillip+L&rft.aulast=Elbaum&rft.aufirst=Phillip&rft.date=1981-10-01&rft.volume=7&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marital+and+Family+Therapy&rft.issn=0194472X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Sex/Sexes/Sexism/Sexist/Sexists; Family/Families; Therapist/Therapists ER - TY - JOUR T1 - Effectiveness of a Service Workers' Action Team (SWAT) for the Elderly AN - 61529204; 198201605 AB - The Service Workers Action Team (SWAT) is a three-year-old community-based demonstration project for the elderly, with the primary goal of improving or maintaining psychosocial & physical functioning. With baseline scores & selected demography data as covariates, obtained through interviews with Miami, Fla, residents, 243 experimental SWAT recipients were compared (MANOVA) with 158 controls after 6 months, with respect to: (1) Hopkin's Symptom Checklist, (2) a social participation scale, (3) a life satisfaction scale, (4) a self-esteem scale, (5) activities of daily living, & (6) 4 selected health-related questions. The f of responses for the experimental group was computed for program satisfaction at the time of follow-up. In terms of psychosocial functioning, the experimental group fared significantly better at 6 months than did the control group. In terms of health, both groups declined in functional status, as evidenced by their scores on activities of daily living, though the experimental Ss still were significantly better than the controls. The majority of the experimental group found the program to be helpful, with suggestions made for program expansion. 4 Tables. HA. JF - Journal of the American Geriatrics Society AU - Stein, Shayna R AU - Linn, Margaret W AU - Weiner, Audrey S AD - Veterans Administration Medical Center, Miami FL 33125 Y1 - 1981/09// PY - 1981 DA - September 1981 SP - 411 EP - 417 VL - 29 IS - 9 SN - 0002-8614, 0002-8614 KW - elderly's psychosocial/physical functioning, Service Workers' Action Team project effectiveness, longitudinal study KW - interviews KW - Miami, Florida, residents KW - Physical KW - Elder/Elders/Elderly KW - Miami, Fla. KW - Social KW - Worker/Workers KW - Psychology/Psychological/ Psychologically/ Psychologism KW - Service/Services KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61529204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Effectiveness+of+a+Service+Workers%27+Action+Team+%28SWAT%29+for+the+Elderly&rft.au=Stein%2C+Shayna+R%3BLinn%2C+Margaret+W%3BWeiner%2C+Audrey+S&rft.aulast=Stein&rft.aufirst=Shayna&rft.date=1981-09-01&rft.volume=29&rft.issue=9&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Psychology/Psychological/ Psychologically/ Psychologism; Social; Physical; Worker/Workers; Miami, Fla.; Service/Services ER - TY - JOUR T1 - Training in the Use of Goal Attainment Scaling AN - 1761703698; 198300371 AB - Goal attainment scaling (GAS) is emerging as one of the most frequently utilized methods of evaluating mental health programs. However, little material is available on the practical problems encountered in training mental health clinicians to use GAS. After detailing some of the difficulties that can be encountered, the training program that evolved when a large-scale research program used GAS as the criterion of outcome is described. 1 Table, 1 Figure. Modified HA. JF - Community Mental Health Journal AU - Choate, Robert AU - Smith, Aaron AU - Cardillo, Joseph E AU - Thompson, Leslie AD - Veterans Administration Medical Center, 1000 Locust St Reno NV 89520 Y1 - 1981/07// PY - 1981 DA - July 1981 SP - 171 EP - 181 VL - 17 IS - 2 SN - 0010-3853, 0010-3853 KW - mental health programs evaluation, goal attainment scaling utilization, training problems/program KW - Goal/Goals KW - Mental health KW - Training/Trainer KW - Scaling KW - Attain/Attainment/Attained KW - Evaluation/Evaluations/Evaluative KW - Program/Programs/Programmer/ Programmers KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761703698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Training+in+the+Use+of+Goal+Attainment+Scaling&rft.au=Choate%2C+Robert%3BSmith%2C+Aaron%3BCardillo%2C+Joseph+E%3BThompson%2C+Leslie&rft.aulast=Choate&rft.aufirst=Robert&rft.date=1981-07-01&rft.volume=17&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental health; Program/Programs/Programmer/ Programmers; Goal/Goals; Attain/Attainment/Attained; Scaling; Training/Trainer; Evaluation/Evaluations/Evaluative ER - TY - JOUR T1 - Psychological Aspects of Data Loss in Outcome Research AN - 61562362; 198301681 AB - Data loss is a plague in outcome studies, particularly for research strategies using significant others to rate home & community adjustment of clients in treatment. Here, the question, "Do psychological factors contribute to data loss?" was asked for 169 consecutively admitted psychiatric clients at a Veterans Administration hospital in Tex who differed in outcome response rates. Clients who evidenced less favorable pretreatment adjustment on the Minnesota Multiphasic Personality Inventory & on psychiatrists' Brief Psychiatric Rating Scales ratings also turned out to be those for whom posttreatment outcome return rates were poorest. The findings suggest data loss is systematic: clients who are less well-adjusted may be underrepresented in program evaluation. Modified HA. JF - Evaluation Review AU - Penk, W E AU - Uebersax, J S AU - Charles, H L AU - Andrews, R H AD - Veterans Administration Medical Center, Dallas TX 75216 Y1 - 1981/06// PY - 1981 DA - June 1981 SP - 392 EP - 396 VL - 5 IS - 3 SN - 0193-841X, 0193-841X KW - data loss, outcome research, psychological aspects KW - Personal Adjustment & Role Skills scale, Minnesota Multiphasic Personality Inventory KW - male veterans/their significant others KW - Veteran/Veterans KW - Data KW - Research/Researcher/Researchers KW - Psychology/Psychological/ Psychologically/ Psychologism KW - article KW - 7220: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61562362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+Review&rft.atitle=Psychological+Aspects+of+Data+Loss+in+Outcome+Research&rft.au=Penk%2C+W+E%3BUebersax%2C+J+S%3BCharles%2C+H+L%3BAndrews%2C+R+H&rft.aulast=Penk&rft.aufirst=W&rft.date=1981-06-01&rft.volume=5&rft.issue=3&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Evaluation+Review&rft.issn=0193841X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Data; Research/Researcher/Researchers; Psychology/Psychological/ Psychologically/ Psychologism; Veteran/Veterans ER - TY - JOUR T1 - Types of Paradoxical Intervention and Indications/Contraindications for Use in Clinical Practice AN - 61547504; 198300683 AB - Paradoxical intervention procedures used to deal with problems in therapy with patients & their families are discussed. These should not, however, be used as a short-cut to working on family interaction. Types of paradoxical mechanisms are described, along with situations that recommend their use or avoidance. Techniques included are: (1) redefinition, an attempt to change the family's understanding of a certain behavioral symptom (eg, a tantrum); (2) escalation, which deliberately stimulates a crisis stage of family interaction through exaggeration of symptoms & bringing symptom response to a conscious stage; & (3) redirection, a modification of escalation in which situations are simulated to bring on certain symptomatic responses. Contraindications for the use of paradoxical techniques are generally specified in the case of loosely-structured or chaotic, childlike, & impulsive families. 1 Table. Modified HA. JF - Family Process AU - Fisher, Lawrence AU - Anderson, Ann AU - Jones, James E AD - Veterans Administration Medical Center, 2615 East Clinton Ave Fresno CA 93703 Y1 - 1981/03// PY - 1981 DA - March 1981 SP - 25 EP - 35 VL - 20 IS - 1 SN - 0014-7370, 0014-7370 KW - paradoxical intervention procedures, indications/contraindications, clinical practice, patients/families KW - Clinic/Clinics/Clinical/Clinician KW - Paradox/Paradoxes/Paradoxical KW - Intervention KW - Family/Families KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61547504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Process&rft.atitle=Types+of+Paradoxical+Intervention+and+Indications%2FContraindications+for+Use+in+Clinical+Practice&rft.au=Fisher%2C+Lawrence%3BAnderson%2C+Ann%3BJones%2C+James+E&rft.aulast=Fisher&rft.aufirst=Lawrence&rft.date=1981-03-01&rft.volume=20&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Family+Process&rft.issn=00147370&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Paradox/Paradoxes/Paradoxical; Intervention; Clinic/Clinics/Clinical/Clinician; Family/Families ER - TY - JOUR T1 - Problems of Families Caring for Alzheimer Patients: Use of a Support Group AN - 61555365; 198200098 AB - An 8-week support group program was conducted for 15 members of the families of Alzheimer patients still living at home. It became clear that home care of an Alzheimer patient created tremendous practical, psychological, & social problems for family members. Frequently discussed problems included lack of support & information from MDs, poor understanding of the disease, depression, a trapped feeling, anger & fear about the patient's behavioral problems, isolation, & the caretaker's loss of self-identity. Group participation was especially beneficial for spouses who functioned as primary care providers. It increased their understanding of the disease, made them feel more supported, & helped them resolve some of the feelings created by the illness. It also helped spouses to become more aware of their own needs & to regain some self-identity in relation to the patient. Such family support programs offer a way to strengthen the emotional well-being & treatment skills of the care-providing family & are an important aid to treatment in Alzheimer's disease. HA. JF - Journal of the American Geriatrics Society AU - Barnes, Robert F AU - Raskind, Murray A AU - Scott, Monte AU - Murphy, Colleen AD - Veterans Administration Medical Center, 4435 Beacon Ave South Seattle WA 98108 Y1 - 1981/02// PY - 1981 DA - February 1981 SP - 80 EP - 85 VL - 29 IS - 2 SN - 0002-8614, 0002-8614 KW - Alzheimer patients, family caretakers' problems KW - support group program KW - Patient/Patients KW - Group/Groups/Grouping/Groupism KW - Family/Families KW - Support/Supports/Supported/ Supporting/ Supportive KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61555365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Problems+of+Families+Caring+for+Alzheimer+Patients%3A+Use+of+a+Support+Group&rft.au=Barnes%2C+Robert+F%3BRaskind%2C+Murray+A%3BScott%2C+Monte%3BMurphy%2C+Colleen&rft.aulast=Barnes&rft.aufirst=Robert&rft.date=1981-02-01&rft.volume=29&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Patient/Patients; Family/Families; Support/Supports/Supported/ Supporting/ Supportive; Group/Groups/Grouping/Groupism ER - TY - JOUR T1 - Understanding the Psychology in Psychological Metaphors AN - 85290912; llba-8205268 AB - To determine whether the well-observed difficulty with psychological-physical metaphors is due to unfamiliarity with psychological concepts, first, second, & third graders (N = 11 each) were administered a task testing comprehension of 6 psychological-physical metaphors & a parallel set of nonmetaphoric personality trait terms. Children were read stories describing characters with either positive (eg, generous, honest) or negative (eg, mean, dishonest), personality characteristics, & asked to indicate which metaphors & trait terms corresponded to the story. Results confirm that while young children recognize nonliteral physical similarities, they do not perceive nonliteral, abstract similarities. 1 Table. I. Mielonen JF - Journal of Child Language AU - Cicone, Michael AU - Gardner, Howard AU - Winner, Ellen AD - Boston Veterans Administration Hospital, 150 South Huntington Ave MA 02130 PY - 1981 SP - 213 EP - 216 VL - 8 IS - 1 SN - 0305-0009, 0305-0009 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85290912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Language&rft.atitle=Understanding+the+Psychology+in+Psychological+Metaphors&rft.au=Cicone%2C+Michael%3BGardner%2C+Howard%3BWinner%2C+Ellen&rft.aulast=Cicone&rft.aufirst=Michael&rft.date=1981-01-01&rft.volume=8&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Language&rft.issn=03050009&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Purification of antigens from urine of a sarcoma patient by affinity chromatography AN - 754878774; 13379105 AB - Previous publications from our laboratory have demonstrated the presence of antigens in the urine of cancer patients detectable by the complement fixation (CF) assay. The purpose of this study was to develop a methodology for purification of these tumor-associated antigen(s) using xenogeneic antisera as a specific immunoabsorbent. Urine possessing high antigen titer by CF was collected from sarcoma patients. Xenoantiserum to the urinary antigens was prepared by injection of concentrated, dialyzed urine mixed with complete Freund's adjuvant into rabbits. Control xenoantisera were obtained by injection of pooled human normal urine in an identical manner. The antisarcoma urine xenoantisera were absorbed with human normal liver and insolubilized human normal serum to remove cross-reacting antibodies to normal human components. The immunoglobulin fraction of the xenoantisera was isolated by ammonium sulfate precipitation and covalently linked to Sepharose 4B beads. Urine from a sarcoma patient was reacted with the immunobeads, and the affinity absorbed antigen(s) were eluted with 3.5 M potassium thiocyanate. The affinity purified urinary antigen had a CF titer of 1:128 against xenoantisera that had been quantitatively absorbed with human normal liver cells and the insolubilized normal human serum. Absorption of the xenoantiserum with cultured allogeneic sarcoma cells removed all activity against the affinity purified antigen(s). The results suggest that the cultured sarcoma cells expressed antigens immunologically similar to those present in the urine of sarcoma patients, and that these antigens can be isolated from urine of cancer patients and purified by affinity chromatography. The affinity purified antigens(s) was labeled with 125I by the vapor phase chloramine-T method, and a radioimmunoassay was developed. By radioimmunoassay, antisarcoma urine xenoantiserum absorbed with human normal liver and insolubilized serum had a titer of 1:4000 against the affinity purified antigen. Xenoantisera to pooled normal human urine treated similarly showed no reactivity to the affinity purified antigen. Polyacrylamide gel electrophoresis of the radiolabeled antigen(s) showed a single peak in the 40,000- to 50,000- dalton range. JF - Journal of Surgical Oncology AU - Huth, James F AU - Gupta, Rishab K AU - Morton, Donald L AD - Division of Oncology, Department of Surgery, UCLA School of Medicine, University of California, Los Angeles, and Surgical Service, Veterans Administration Medical Center, Sepulveda Y1 - 1981 PY - 1981 DA - 1981 SP - 237 EP - 247 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 18 IS - 3 SN - 0022-4790, 0022-4790 KW - Biotechnology and Bioengineering Abstracts KW - Chloramine-T KW - Hepatocytes KW - Xenoantisera KW - Potassium KW - Precipitation KW - Radioimmunoassay KW - Gel electrophoresis KW - Affinity chromatography KW - Vapors KW - Antisera KW - Ammonium sulfate KW - Urine KW - Complement fixation KW - Liver KW - Sarcoma KW - Purification KW - Freund's adjuvant KW - Immunoglobulins KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754878774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Purification+of+antigens+from+urine+of+a+sarcoma+patient+by+affinity+chromatography&rft.au=Huth%2C+James+F%3BGupta%2C+Rishab+K%3BMorton%2C+Donald+L&rft.aulast=Huth&rft.aufirst=James&rft.date=1981-01-01&rft.volume=18&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930180304 L2 - http://www3.interscience.wiley.com/journal/112720138/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Chloramine-T; Hepatocytes; Xenoantisera; Potassium; Precipitation; Radioimmunoassay; Gel electrophoresis; Affinity chromatography; Antisera; Vapors; Ammonium sulfate; Complement fixation; Urine; Sarcoma; Liver; Purification; Freund's adjuvant; Immunoglobulins DO - http://dx.doi.org/10.1002/jso.2930180304 ER - TY - JOUR T1 - Complications from staging laparotomy for hodgkin disease AN - 754561667; 13379015 AB - Nonspecific complications from staging laparotomy are usually related to general anesthesia or abdominal exploration. Specific complications for the procedure do exist: intubation difficulties during administration of anesthesia to patients with untreated mediastinal disease, sepsis in up to 20% of patients, depending on stage of disease and intensity of postoperative chemotherapy and radiotherapy, arterial and possibly venous thromboemboli from extensive retroperitoneal node dissection, pancreatitis, small bowel obstruction from adhesions to node biopsy sites, operative mishaps, subphrenic abscesses, and bleeding from liver biopsies. Certain patient subpopulations are at especially high risk for some of these complications and their identification and possible measures to minimize such problems are proposed. JF - Journal of Surgical Oncology AU - Kaiser, C William AD - Department of Surgery, Pondville Hospital, Walpole, Massachusetts, and Veterans Administration Hospital and the Department of Surgery, Tufts University School of Medicine, Boston, Massachusetts PY - 1981 SP - 319 EP - 325 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 4 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Hodgkin's disease KW - Subpopulations KW - Chemotherapy KW - Radiotherapy KW - Biopsy KW - Abscesses KW - Intubation KW - Sepsis KW - Anesthesia KW - Risk factors KW - Bleeding KW - Intestine KW - Exploration KW - Nodes KW - Pancreatitis KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754561667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Complications+from+staging+laparotomy+for+hodgkin+disease&rft.au=Kaiser%2C+C+William&rft.aulast=Kaiser&rft.aufirst=C&rft.date=1981-01-01&rft.volume=16&rft.issue=4&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930160404 L2 - http://www3.interscience.wiley.com/journal/112721161/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Hodgkin's disease; Chemotherapy; Subpopulations; Radiotherapy; Biopsy; Intubation; Abscesses; Sepsis; Anesthesia; Risk factors; Intestine; Bleeding; Exploration; Nodes; Pancreatitis DO - http://dx.doi.org/10.1002/jso.2930160404 ER - TY - JOUR T1 - Group Therapy by Phone: A Cognitive Behavioral Program for Visually Impaired Elderly AN - 61571524; 198300642 AB - An experimental study was conducted to evaluate the effectiveness of an outreach program for a group of 24 isolated elderly clients who had been legally blind for many years. Cost-efficient group therapy by phone quickly identified those persons who were at risk for affective disorder & also provided information & socialization to the lonely & neglected. Ss were administered tests to evaluate depression, loneliness, & life satisfaction before & after phone counseling. Implications for clinical practice suggest a need for marked changes in service delivery to the blind, emphasizing outpatient supportive intervention. 3 Tables. Modified HA. JF - Social Work in Health Care AU - Evans, Ron L AU - Jaureguy, Beth M AD - Veterans Administration Medical Center, 4435 Beacon Ave South Seattle WA 98108 Y1 - 1981/01// PY - 1981 DA - January 1981 SP - 79 EP - 90 VL - 7 IS - 2 SN - 0098-1389, 0098-1389 KW - group therapy via telephone, cognitive behavioral program, visually impaired elderly KW - experiment KW - Group therapy KW - Behavior/Behavioral KW - Cognition/Cognitive KW - Elder/Elders/Elderly KW - Vision/Visual/Visibility KW - Program/Programs/Programmer/ Programmers KW - Telephone/Telephones KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61571524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Group+Therapy+by+Phone%3A+A+Cognitive+Behavioral+Program+for+Visually+Impaired+Elderly&rft.au=Evans%2C+Ron+L%3BJaureguy%2C+Beth+M&rft.aulast=Evans&rft.aufirst=Ron&rft.date=1981-01-01&rft.volume=7&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Group therapy; Telephone/Telephones; Behavior/Behavioral; Elder/Elders/Elderly; Program/Programs/Programmer/ Programmers; Cognition/Cognitive; Vision/Visual/Visibility ER - TY - JOUR T1 - Training Older People in Empathy: Effects on Empathy, Attitudes, and Self-Exploration AN - 61539689; 198200806 AB - To examine the effect of empathy training on empathy, self-exploration, & key attitudes in older people, 28 older people were randomly assigned to 1 of 3 groups: empathy training, discussion, or control. For 8 weeks the training group practiced empathy as a helping skill; one control group discussed the problems of older people, but the other met only to take the tests. Unlike the control groups, the training group improved significantly on three measures of empathy & showed significant gains in self-exploration. Questionnaire responses showed that these gains in skill brought no change in attitudes. The findings show that older people can change a portion of their interpersonal style & learn new ways of helping. 4 Figures. HA. JF - International Journal of Aging and Human Development AU - Isquick, Michael F AD - Veterans Administration Medical Center, Cleveland OH 44106 Y1 - 1981///0, PY - 1981 DA - 0, 1981 SP - 1 EP - 14 VL - 13 IS - 1 SN - 0091-4150, 0091-4150 KW - empathy/attitudes/self-exploration KW - empathy training KW - questionnaire KW - older people KW - Empathy/Empathetic KW - Elder/Elders/Elderly KW - Attitude/Attitudes/Attitudinal KW - Training/Trainer KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61539689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Aging+and+Human+Development&rft.atitle=Training+Older+People+in+Empathy%3A+Effects+on+Empathy%2C+Attitudes%2C+and+Self-Exploration&rft.au=Isquick%2C+Michael+F&rft.aulast=Isquick&rft.aufirst=Michael&rft.date=1981-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Aging+and+Human+Development&rft.issn=00914150&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Empathy/Empathetic; Attitude/Attitudes/Attitudinal; Training/Trainer; Elder/Elders/Elderly ER - TY - JOUR T1 - Termination of Life Support Systems in the Elderly: General Discussion: "Company in Battle" AN - 61475702; 198501465 AB - Suffering, countertransference, & ethical & legal dilemmas arise for those who care for a dying person. The caregivers may experience delayed stress reactions, hopelessness, & humiliation. Periodic rotation to other work may palliate their suffering. Ethical dilemmas arise when dissonant cognitive models of the person alive & the patient dying are not reconciled. The clinician's work-life frames ethical categories in terms of the individual instance, not the general good. The law sets limits. Appeals to the law occur when those involved with the dying person lack a sense of community. Restoring communication among those involved may partially assuage their loneliness. AA. JF - Journal of Geriatric Psychiatry AU - Merowitz, Martin AD - Veterans Administration Outpatient Clinic, 17 Court St Boston MA 02108 Y1 - 1981///0, PY - 1981 DA - 0, 1981 SP - 87 EP - 89 VL - 14 IS - 1 SN - 0022-1414, 0022-1414 KW - life support systems termination, elderly, caregivers' reactions KW - Elder/Elders/Elderly KW - Care givers KW - Euthanasia KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61475702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geriatric+Psychiatry&rft.atitle=Termination+of+Life+Support+Systems+in+the+Elderly%3A+General+Discussion%3A+%22Company+in+Battle%22&rft.au=Merowitz%2C+Martin&rft.aulast=Merowitz&rft.aufirst=Martin&rft.date=1981-01-01&rft.volume=14&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geriatric+Psychiatry&rft.issn=00221414&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Euthanasia; Elder/Elders/Elderly; Care givers ER - TY - JOUR T1 - The Processing and Disposition of Incompetent Mentally Ill Offenders AN - 61092620; 84N6808 AB - The increasing interaction between the criminal justice & mental health systems has implications for a unified mode of social control that are disturbing to professionals & laymen alike. This interaction is dramatized in the issue of competency to stand trial. Case studies are presented describing dispositions of offenders who had been found incompetent, were hospitalized, & were subsequently returned to court (N = 431 Ms from Dade & Broward Counties, Fla). It was expected that in court dispositions, the social power of the individual would be inversely related to the severity of court sanctions. Social power was based on the variables of race, age, marital status, education, employment, & skills; dispositions were categorized according to four measures of severity, ie, release to the community, rehospitalization, imprisonment, or release with stipulations for further treatment. In procedural outcomes, nearly 80% of the offenders were required to remain within the criminal justice or mental health systems. While overall, social power variables were not related to dispositions, blacks & Cubans were more likely than whites to receive more severe dispositions (ie, hospitalization, imprisonment, or conditional release). 7 Tables, 21 References. D. Dunseath. JF - Law and Human Behavior AU - Williams, Wright AU - Miller, Kent S AD - Veterans Administration Medical Center, Houston TX 77211 Y1 - 1981///0, PY - 1981 DA - 0, 1981 SP - 245 EP - 261 VL - 5 IS - 4 SN - 0147-7307, 0147-7307 KW - incompetent mentally ill offenders, processing/disposition KW - individual's social power, case studies KW - male offenders, Dade/Broward Counties, Florida KW - Competence/Competency KW - Processing KW - Disposition KW - Offender/Offenders KW - Mental illness/Mentally ill KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61092620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Law+and+Human+Behavior&rft.atitle=The+Processing+and+Disposition+of+Incompetent+Mentally+Ill+Offenders&rft.au=Williams%2C+Wright%3BMiller%2C+Kent+S&rft.aulast=Williams&rft.aufirst=Wright&rft.date=1981-01-01&rft.volume=5&rft.issue=4&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Law+and+Human+Behavior&rft.issn=01477307&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - LHBEDM N1 - SubjectsTermNotLitGenreText - Competence/Competency; Mental illness/Mentally ill; Offender/Offenders; Disposition; Processing ER - TY - JOUR T1 - Cost of high school soccer injuries AN - 20751089; 10092425 AB - This study examines the cost of high school soccer injuries. Data was collected from the files of the largest single insurer of secondary school students in six western states. Analysis was made through a specially programmed Qantel 1300 computer (Empire Com puter Systems, Seattle, Washington).The average claim cost was $127.29 for injuries in 1976 to 1977, ranging from the lowest in Washington to the highest in California. During this period 436 claims from 10,634 players were reported.Relatively minor injuries (sprains, strains, contu sions, and abrasions) accounted for 75.9% of all injuries but only 49.4% of all costs; lower extremity injuries accounted for more than one-half of all injuries and costs. Knee injuries alone represented 11.7% of all injuries-28.2% of all medical costs paid by the insurance companies.Injuries occur only one-fifth as frequently in soccer, compared with football. It is anticipated that medical expenses for soccer players will be less than 16% of expenses incurred by an equal number of football players. JF - American Journal of Sports Medicine AU - Pritchett, James W AD - Phoenix Veterans Administration Medical Center and Phoenix Orthopedic Residents Training Program, Phoenix, Arizona Y1 - 1981/01// PY - 1981 DA - Jan 1981 SP - 64 EP - 66 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 9 IS - 1 SN - 0363-5465, 0363-5465 KW - soccer KW - Physical Education Index; Health & Safety Science Abstracts KW - Injuries KW - Computers KW - Legs KW - extremities KW - Students KW - Insurance KW - sports related injuries KW - High schools KW - schools KW - INE, USA, Washington, Seattle KW - Soccer (football) KW - USA, California KW - Sports medicine KW - injuries) KW - Soccer (football KW - Athletes KW - H 11000:Diseases/Injuries/Trauma KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20751089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Cost+of+high+school+soccer+injuries&rft.au=Pritchett%2C+James+W&rft.aulast=Pritchett&rft.aufirst=James&rft.date=1981-01-01&rft.volume=9&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658100900116 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - High schools; Injuries; Computers; Legs; Soccer (football); Students; Sports medicine; injuries); Athletes; Soccer (football; sports related injuries; schools; extremities; Insurance; INE, USA, Washington, Seattle; USA, California DO - http://dx.doi.org/10.1177/036354658100900116 ER - TY - JOUR T1 - Characteristics of High and Low Self-Esteem in the Elderly AN - 1463025149; 84O3867 AB - Self-esteem is fundamental to the elderly's experience of life. To examine background & personality characteristics associated with low & high self-esteem in the elderly, 250 Ms & Fs aged 65+, randomly selected from housing projects in Miami, Fla, were interviewed. Rs' level of self-esteem did not appear to be related to age, income, education, or living arrangement. However, the low self-esteem group had poorer self-reported health, more pain, & higher disability; this group also had significantly higher scores on depression, anxiety, & somatization, & a more external locus of control orientation, both with & without health variables controlled. These data suggest that intervention may be a viable aid in promoting better feelings toward the self for elderly persons. 4 Tables, 29 References. Modified HA. JF - International Journal of Aging and Human Development AU - Hunter, Kathleen I AU - Linn, Margaret W AU - Harris, Rachel AD - Veterans Administration Medical Center, 1201 Northwest 16th St Miami FL 33125 Y1 - 1981///0, PY - 1981 DA - 0, 1981 SP - 117 EP - 126 VL - 14 IS - 2 SN - 0091-4150, 0091-4150 KW - elderly, low/high self-esteem KW - background/personality characteristics KW - interviews KW - persons aged 65+ KW - Elder/Elders/Elderly KW - Self-esteem KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463025149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Aging+and+Human+Development&rft.atitle=Characteristics+of+High+and+Low+Self-Esteem+in+the+Elderly&rft.au=Hunter%2C+Kathleen+I%3BLinn%2C+Margaret+W%3BHarris%2C+Rachel&rft.aulast=Hunter&rft.aufirst=Kathleen&rft.date=1981-01-01&rft.volume=14&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Aging+and+Human+Development&rft.issn=00914150&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJADDT N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Self-esteem ER - TY - JOUR T1 - Comparison of bacterial luminescence and fish bioassay results for fossil-fuel process waters and phenolic constituents AN - 13835046; S198516284 AB - Bioassays using a luminescent marine bacterium (Photobacterium fisheri) were performed on a variety of fossil fuel process wastewaters and some specific phenolic contaminants in aqueous solution. The results, in terms of the concentration causing a 50 per cent inhibition of luminescence (EC50) were compared with the LC50 values obtained using either static or continuous flow bioassay procedures with different fish species. The EC50 values for a range of process wastewaters correlated well with the LC50 values obtained from 96 h continuous flow assays with rainbow trout, but not with results for fathead minnows. However a significant correlation with 24 h static bioassay LC50 values using fathead minnows was obtained for another group of samples. Both rainbow trout and fathead minnow LC50 values were lower than the luminescent EC50 values for the phenolic constituents, indicating that the luminescent bioassay procedure cannot completely supersede the use of fish as the test organism in assessing the toxicity of contaminants in aquatic organisms. JF - Aquatic Toxicology and Hazard Assessment. ASTM Symposium Proceedings, STP 737 AU - Lebsack, ME AU - Anderson, AD AU - DeGraeve, G M AU - Bergman, H L AD - Veterans Administration Hospital, Bronx, N.Y. Y1 - 1981 PY - 1981 DA - 1981 SP - 11 EP - 356,11 KW - Fish (see also individual groups listed below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13835046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Toxicology+and+Hazard+Assessment.+ASTM+Symposium+Proceedings%2C+STP+737&rft.atitle=Comparison+of+bacterial+luminescence+and+fish+bioassay+results+for+fossil-fuel+process+waters+and+phenolic+constituents&rft.au=Lebsack%2C+ME%3BAnderson%2C+AD%3BDeGraeve%2C+G+M%3BBergman%2C+H+L&rft.aulast=Lebsack&rft.aufirst=ME&rft.date=1981-01-01&rft.volume=&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Aquatic+Toxicology+and+Hazard+Assessment.+ASTM+Symposium+Proceedings%2C+STP+737&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Relationship between Learning Disabilities and Juvenile Delinquency AN - 61087820; 82M6805 AB - The incidence of juvenile delinquency in the US is increasing, & children are becoming involved in delinquent activity at a much younger age. Learning disabilities have been associated with juvenile delinquency. Learning disabled children are labeled by teachers & peers as different, which may alienate them from 'normal society'. If children reject social institutions such as school, they may seek alternative, often delinquent, activities. Learning disabled children must be identified so that programs that minimize their disabilities & emphasize their strengths can be instituted. Since adjudicated delinquents of normal intelligence show significant academic underachievement, correctional programs must recognize the possibility of learning disability. Vocational training emphasizing an individual's strengths can be an effective alternative to traditional educational programs for delinquent juveniles. Modified HA. JF - Perceptual and Motor Skills AU - McKay, Susan AU - Brumback, Roger A AD - Veterans Administration Medical Center, Fargo ND 58102 Y1 - 1980/12// PY - 1980 DA - December 1980 SP - Dec, 1223 EP - 1226 VL - 51 IS - 3 SN - 0031-5125, 0031-5125 KW - juvenile delinquency KW - learning disabilities KW - Disable/Disabled/Disability/ Disabilities KW - Delinquency, juvenile KW - Learning/Learned KW - article KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61087820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+Motor+Skills&rft.atitle=Relationship+between+Learning+Disabilities+and+Juvenile+Delinquency&rft.au=McKay%2C+Susan%3BBrumback%2C+Roger+A&rft.aulast=McKay&rft.aufirst=Susan&rft.date=1980-12-01&rft.volume=51&rft.issue=3&rft.spage=Dec&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+Motor+Skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PMOSAZ N1 - SubjectsTermNotLitGenreText - Delinquency, juvenile; Learning/Learned; Disable/Disabled/Disability/ Disabilities ER - TY - JOUR T1 - Life Satisfaction-Aspirations and Alcohol Use: A Preliminary Report AN - 60085720; 81L8204 AB - Utilizing a 403-item interview, successfully conducted with 2,029 randomly selected individuals, significant differences were found to exist among individuals with different drinking patterns, with respect to life situation 5 years ago (p less than 0.001) & present satisfaction (p less than 0.005). However, no significant difference in future aspirations could be identified. In addition, using an 'unrealistic hopefulness' coefficient, higher future aspiration levels than would normally be expected were found. Those individuals who drink more now than 5 years ago consistently show the lowest mean satisfaction scores on the Cantril Self-Anchoring Striving Scale. Those whose drinking pattern has remained stable over time consistently perceived themselves highest on the scale both 5 years ago & now, regardless of present drinking pattern. 3 Tables, 8 Figures. Modified HA. JF - Social Indicators Research AU - Levy, Alan B AU - Bell, Roger A AU - Lin, Elizabeth AD - Veterans Administration Hospital, Los Angeles CA Y1 - 1980/12// PY - 1980 DA - December 1980 SP - 441 EP - 452 VL - 8 IS - 4 SN - 0303-8300, 0303-8300 KW - life satisfaction, aspirations KW - alcohol use KW - Alcohol KW - Satisfaction KW - Life (see also Living) KW - Aspiration/Aspirational/Aspirations KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60085720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Indicators+Research&rft.atitle=Life+Satisfaction-Aspirations+and+Alcohol+Use%3A+A+Preliminary+Report&rft.au=Levy%2C+Alan+B%3BBell%2C+Roger+A%3BLin%2C+Elizabeth&rft.aulast=Levy&rft.aufirst=Alan&rft.date=1980-12-01&rft.volume=8&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Social+Indicators+Research&rft.issn=03038300&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - SINRDZ N1 - SubjectsTermNotLitGenreText - Alcohol; Aspiration/Aspirational/Aspirations; Life (see also Living); Satisfaction ER - TY - JOUR T1 - Follow-Up of Vietnam Veterans: II. Social Adjustment AN - 61059621; 85O4401 AB - Continuing an investigation of drug use among Vietnam veterans ("Follow-Up of Vietnam Veterans: I. Relapse to Drug Use after Vietnam Service," Drug & Alcohol Dependence, 1980, 5, 5, 333), the same sample of 202 veterans was divided into 3 groups according to their inservice narcotics use: frequent users (N = 98), occasional users (N = 55), & nonusers (N = 49). Using a blind interview procedure, the 3 groups were found to differ in the areas of employment/education, family adjustment, physical health, & depression. A composite "social adjustment factor" (SAF) was derived from these 4 areas, & multiple correlations were computed to assess the effect of Vietnam drug use on the SAF when preservice variables were held constant. Both the SAF & two of its components, family adjustment & depression, continued to correlate significantly with the Vietnam drug group after accounting for the influence of preservice variables. Correlations between the two components employment/education & physical health with the Vietnam drug group were no longer significant. It is concluded that current social adjustment is determined by the interaction of preservice conditions & the Vietnam experience itself. 2 Tables, 5 References. Modified HA. JF - Drug and Alcohol Dependence AU - Nace, E P AU - O'Brien, C P AU - Mintz, J AU - Meyers, A L AU - Ream, N AD - Veterans Administration Medical Center U Pennsylvania, Philadelphia 19104 Y1 - 1980/10// PY - 1980 DA - October 1980 SP - 209 EP - 214 VL - 6 IS - 4 SN - 0376-8716, 0376-8716 KW - Vietnam veterans' drug use KW - social adjustment KW - interviews KW - Veteran/Veterans KW - Drug/Drugs KW - Vietnam/Vietnamese KW - Adjustment/Adjustments KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61059621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Follow-Up+of+Vietnam+Veterans%3A+II.+Social+Adjustment&rft.au=Nace%2C+E+P%3BO%27Brien%2C+C+P%3BMintz%2C+J%3BMeyers%2C+A+L%3BReam%2C+N&rft.aulast=Nace&rft.aufirst=E&rft.date=1980-10-01&rft.volume=6&rft.issue=4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Vietnam/Vietnamese; Veteran/Veterans; Adjustment/Adjustments; Drug/Drugs ER - TY - JOUR T1 - Chronic Alcohol Abuse and High Density Lipoprotein Cholesterol AN - 1842511771; 17629435 AB - The possible use of high density lipoprotein cholesterol (HDLC) as a marker of alcohol abuse was studied in 92 alcoholic patients entering an inpatient treatment program. The average HDLC levels of 68 male patients (66 plus or minus 23 mg/dl) and 24 female patients (83 plus or minus 18 mg/dl) were significantly higher than the values for the corresponding control groups of similar ages. Approximately 20% of the male patients had HDLC levels over the mean plus or minus 2 SD over the control groups. Following 2 wk of alcohol abstinence. the HDLC levels decreased to the control range. HDLC, as a measure of alcohol abuse, may be especially useful in combination with determination of gamma glutamyl transpeptidase (GGT), since these two tests singly or in combination were elevated in 65% of the male and 85% of the female patients. JF - Alcoholism: Clinical and Experimental Research AU - Barboriak, Joseph J AU - Jacobson, George R AU - Cushman, Paul AU - Herrington, Roland E AU - Lipo, Robert F AU - Daley, Mark E AU - Anderson, Alfred J AD - Research Service, Wood Veterans Administration Medical Center, De Paul Rehabilitation Hospital, and the Departments of Pharmacology, Psychiatry and Preventive Medicine, the Medical College of Wisconsin, Milwaukee, Wise. Y1 - 1980/10// PY - 1980 DA - October 1980 SP - 346 EP - 349 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 4 IS - 4 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts KW - gamma -Glutamyltransferase KW - Age KW - Lipoproteins (high density) KW - Alcoholism KW - Cholesterol KW - Drug abuse KW - Alcoholics KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842511771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Chronic+Alcohol+Abuse+and+High+Density+Lipoprotein+Cholesterol&rft.au=Barboriak%2C+Joseph+J%3BJacobson%2C+George+R%3BCushman%2C+Paul%3BHerrington%2C+Roland+E%3BLipo%2C+Robert+F%3BDaley%2C+Mark+E%3BAnderson%2C+Alfred+J&rft.aulast=Barboriak&rft.aufirst=Joseph&rft.date=1980-10-01&rft.volume=4&rft.issue=4&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.1980.tb04829.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - gamma -Glutamyltransferase; Age; Alcoholism; Lipoproteins (high density); Cholesterol; Drug abuse; Alcoholics; Ethanol DO - http://dx.doi.org/10.1111/j.1530-0277.1980.tb04829.x ER - TY - JOUR T1 - The Hill-Sachs lesion. An experimental study AN - 20076403; 10092379 AB - The Hill-Sachs lesion is an important indication of previous anterior shoulder dislocation. We created Hill-Sachs lesions by using cadaveric humeri. Roentgenographs of these cadaveric humeri in the standard projections were then taken. Under fluoroscopy, new projections of the cadaveric humeri were obtained. In a clinical study, 15 patients (14 men and 1 woman; age range, 23 to 63 years; mean, 30 years) with known recurrent anterior shoulder dislocations were evaluated by using standard and new roentgenographic projections. On the basis of the cadaveric and clinical studies, the optimal methods for detect ing Hill-Sachs lesions include the following three roentgeno grams : anteroposterior view of the glenohumeral joint with the humerus in 45 degree internal rotation, the notch (Stryker) view, and the modified Didiee view. JF - American Journal of Sports Medicine AU - Danzig, Larry A AU - Greenway, Guerdon AU - Resnick, Donald AD - Division of Orthopaedic Surgery, the Department of Radiology, University Hospital, University of California, San Diego, School of Medicine, and Veterans Administration Medical Center, San Diego, California Y1 - 1980/09// PY - 1980 DA - Sep 1980 SP - 328 EP - 332 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 8 IS - 5 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Dislocations KW - Men KW - Shoulders KW - Patients KW - Standards KW - Sports medicine KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20076403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=The+Hill-Sachs+lesion.+An+experimental+study&rft.au=Danzig%2C+Larry+A%3BGreenway%2C+Guerdon%3BResnick%2C+Donald&rft.aulast=Danzig&rft.aufirst=Larry&rft.date=1980-09-01&rft.volume=8&rft.issue=5&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658000800506 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Men; Dislocations; Standards; Patients; Shoulders; Sports medicine; Joints DO - http://dx.doi.org/10.1177/036354658000800506 ER - TY - JOUR T1 - A Simple Method For Plating and Cloning Ciliates and Other Protozoa. METHOD FOR CLONING PROTOZOA AN - 1069197214; 17142552 AB - SYNOPSIS. A simple method is described for plating and cloning ciliates and other protozoa, based on a principle differing from that traditionally used for plating and cloning bacteria and other microorganisms. This procedure, referred to as the silicone-oil-plating-procedure (SOPP), involves vortexing small volumes of culture medium containing protozoa with larger volumes of a non-toxic silicone oil and plating the resulting unstable emulsion in small plastic petri plates. Discrete microdroplets of culture medium form containing protozoa entrapped and immobilized between the hydrophobic surfaces of the plastic petri dish and the oil. Protozoa, isolated by this method grow, divide, and multiply to form clones. the procedure may be used for plating and cloning protozoa in bacterized and axenic culture. Variations of the basic method may be applied to isolating protozoa from the wild, washing protozoa to remove microorganisms, screening for potential mutants, and for replica plating. JF - Journal of Eukaryotic Microbiology AU - SOLDO, A T AU - Brickson, Sa AD - Research Laboratories of the Veterans Administration. Medical Center and Department of Biochemistry, University of Miami School of Medicine, Miami, Florida 33125 Y1 - 1980/08// PY - 1980 DA - Aug 1980 SP - 328 EP - 331 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 27 IS - 3 SN - 1066-5234, 1066-5234 KW - ASFA Aquaculture Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Pure culture KW - Screening KW - Clones KW - Silicones KW - Replica plating KW - Hydrophobicity KW - Axenic culture KW - Ciliates KW - Emulsions KW - Protists KW - Methodology KW - Oil KW - Protozoa KW - Microbiology KW - Microorganisms KW - Plastics KW - Aquaculture techniques KW - Q5 08503:Characteristics, behavior and fate KW - K 03300:Methods KW - O 5060:Aquaculture KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1069197214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Eukaryotic+Microbiology&rft.atitle=A+Simple+Method+For+Plating+and+Cloning+Ciliates+and+Other+Protozoa.+METHOD+FOR+CLONING+PROTOZOA&rft.au=SOLDO%2C+A+T%3BBrickson%2C+Sa&rft.aulast=SOLDO&rft.aufirst=A&rft.date=1980-08-01&rft.volume=27&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+Eukaryotic+Microbiology&rft.issn=10665234&rft_id=info:doi/10.1111%2Fj.1550-7408.1980.tb04271.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Number of references - 9 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - Clones; Screening; Microbiology; Microorganisms; Axenic culture; Emulsions; Aquaculture techniques; Methodology; Protists; Pure culture; Oil; Silicones; Protozoa; Replica plating; Hydrophobicity; Plastics; Ciliates DO - http://dx.doi.org/10.1111/j.1550-7408.1980.tb04271.x ER - TY - JOUR T1 - Sex Education in the Home: An Empirical Task Analysis AN - 61066079; 82M6622 AB - Data from several studies have indicated that direct parental involvement in sex education is infrequent. One hypothesis advanced to explain this is the poor sex education of parents themselves. Response acquisition training programs have been used to improve parents' skill & comfort in this parenting task. To improve the generalizability of such training programs, 59 parents were interviewed to determine what types of sexually-oriented situations occur in the home. Interview transcriptions provided a set of 392 sex education situations, which were categorized into 21 topic areas. Analysis revealed no difference in number or type of sexual situations occurring as a function of the child's sex, but significant differences as a function of age. Preadolescent children tended to present more sexual situations to their parents than did adolescent children. Home-based situations also showed that older children were less concerned with their own bodies & more concerned with the interpersonal nature of sexuality. Suggestions for ways to increase the generalizability of parental sex education programs are offered. 3 Tables. Modified HA. JF - Journal of Sex Research AU - Gilbert, Francis S AU - Bailis, Karen L AD - Sepulveda Veterans' Administration Medical Center, CA 91343 Y1 - 1980/05// PY - 1980 DA - May 1980 SP - 148 EP - 161 VL - 16 IS - 2 SN - 0022-4499, 0022-4499 KW - sex education, parental involvement KW - empirical task analysis KW - interviews KW - parents KW - Sex/Sexes/Sexism/Sexist/Sexists KW - Education/Educational/Educator/ Educators/ Educationally KW - Parent/Parents/Parental KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61066079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Sex+Research&rft.atitle=Sex+Education+in+the+Home%3A+An+Empirical+Task+Analysis&rft.au=Gilbert%2C+Francis+S%3BBailis%2C+Karen+L&rft.aulast=Gilbert&rft.aufirst=Francis&rft.date=1980-05-01&rft.volume=16&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Journal+of+Sex+Research&rft.issn=00224499&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSXRAJ N1 - SubjectsTermNotLitGenreText - Sex/Sexes/Sexism/Sexist/Sexists; Education/Educational/Educator/ Educators/ Educationally; Parent/Parents/Parental ER - TY - RPRT T1 - National Survey of Veterans. Summary Report. AN - 63691632; ED187249 AB - Principal findings of a mail survey undertaken in 1977 to collect data on the socioeconomic characteristics of veterans, their usage of various veteran benefits in the past--including education benefits--and their plans for usage of other benefits in the future are summarized. Among the data reported are the following: percent of veterans receiving Veterans Administration (VA) benefits during 1977 and since leaving the military; percent of veterans hospitalized in 1977 or ever hospitalized; reasons for not using a VA medical center for treatment; age distribution, income, and type of insurance of hospitalized veterans; percent of veterans receiving outpatient care in 1977 by source; age distribution, income, and medical conditions of outpatient veterans; percent of veterans having dental care, 1977; percent of veterans hospitalized by service-connected disability, 1977; disposition of compensation and pension claims; disabled veterans by race and degree of disability; veterans employment status by degree of disability; usage of GI life insurance; number of trainees for three GI Bills; reasons for not training after military service; GI Bill trained veterans' completion rates by race, type of training, and period of service; percent of veterans who used a VA home loan; and type of burial expected. The chapter on education and rehabilitation includes data on education at separation from active duty, education at separation compared with current education, counseling, employment status and training type, satisfaction with VA educational assistance, reasons for not entering training, and GI Bill education and training for disabled veterans. Sources of the survey data and reliability of the estimates are discussed. A sample questionnaire and additional statistical tables are included. (SW) AU - Hammond, Richard Y1 - 1980/01// PY - 1980 DA - January 1980 SP - 200 PB - Superintendent of Documents, US Government Printing Office, Washington, DC 20402 ($4.50) KW - GI Bill KW - Veterans Administration KW - ERIC, Resources in Education (RIE) KW - Employment Level KW - Housing KW - Trade and Industrial Education KW - Access to Education KW - Socioeconomic Status KW - Males KW - Patients KW - Higher Education KW - National Surveys KW - Insurance KW - Secondary Education KW - Income KW - Veterans KW - Disabilities KW - Technical Education KW - Fringe Benefits KW - Participant Characteristics KW - Veterans Education KW - Medical Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63691632?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Introduction of Nursing Research into the Clinical Setting T2 - American Sociological Association AN - 61736239; 80S12434 AB - Discussed is the problematic nature of the introduction of nursing research into the clinical setting of a large acute care/research & teaching hospital where the dominant model for research is that of experimental bio-medicine conducted mainly by MDs who are preponderantly men. In contrast, the majority of nurses in the setting are women who are unfamiliar with research in general, know very little about research in nursing, & are skeptical about research activity as part of clinical practice for nurses. Focus is on how the institution whose raison d'etre is the provision of clinical patient care & services, responds to the conduct of research by its nursing staff -- an activity for which the institution & the nurses themselves are not fully prepared. Dealt with are: (1) the legitimization of research activity by clinical nurses, (2) the development of a research reference group for nurse clinicians, & (3) the fostering of a research posture in clinical nurse investigators. Data derive largely from personal experience over a four-year period. JF - American Sociological Association AU - Davis, Marcella Z Y1 - 1980///0, PY - 1980 DA - 0, 1980 KW - nursing research, clinical setting KW - institutional response, legitimation, research reference group KW - Clinic/Clinics/Clinical/Clinician KW - Research/Researcher/Researchers KW - Nurse/Nurses/Nursing KW - proceeding KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61736239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Sociological+Association&rft.atitle=Introduction+of+Nursing+Research+into+the+Clinical+Setting&rft.au=Davis%2C+Marcella+Z&rft.aulast=Davis&rft.aufirst=Marcella&rft.date=1980-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1980 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - State Health Care Policymaking: The Tennessee Primary Care Act of 1973 AN - 61565705; 198300449 AB - Primary care has become a peripheral element in US medicine, leading to present efforts to fill a perceived void in this area. Despite this lack, MDs have generally prevented local health departments from providing primary care services. One major exception is examined: provision of primary care in medically underserved areas of Tenn by the Dept of Public Health. The sources & development of this policy were investigated through fieldwork, including interviews with the chief administrator of the program. A variety of interest groups are identified, including MDs, nurses, primary health care centers, the Public Health Dept, & various legislative groups. The bill to establish primary care centers was not a source of controversy when passed; its limited scope, its timing, & the well-planned support of the governor were the major reasons. The program has since evoked some opposition from groups of MDs & pharmacists who feel that the centers compete with them. Passage of the act appears to be a case of the adroit use of normal political processes rather than an exceptional development. W. H. Stoddard. JF - Journal of Health Politics, Policy and Law AU - Crawford, R Vincent AD - Veterans Administration Medical Center, Durham NC 27707 Y1 - 1980/01// PY - 1980 DA - January 1980 SP - 691 EP - 702 VL - 4 IS - 4 SN - 0361-6878, 0361-6878 KW - medical services, state policy making, Tennessee 1973 Primary Care Act KW - Health care KW - State/States KW - Medical KW - Tennessee KW - Primary/Primacy KW - Policymaker/Policy making KW - Service/Services KW - article KW - 7210: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61565705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Politics%2C+Policy+and+Law&rft.atitle=State+Health+Care+Policymaking%3A+The+Tennessee+Primary+Care+Act+of+1973&rft.au=Crawford%2C+R+Vincent&rft.aulast=Crawford&rft.aufirst=R&rft.date=1980-01-01&rft.volume=4&rft.issue=4&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Politics%2C+Policy+and+Law&rft.issn=03616878&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical; Service/Services; State/States; Policymaker/Policy making; Tennessee; Primary/Primacy; Health care ER - TY - JOUR T1 - Educational Preparation for Social Work Administrators: A Survey AN - 61564891; 198301931 AB - There has been considerable disagreement over what is considered to be optimal educational preparation for social work administrators. Findings are presented from a questionnaire survey of 285 practicing social work administrators in regard to their valuation of master of social work (MSW) & post-MSW education & training, significant gaps in their educational preparation, & the relevance of their educational preparation for administrative functioning. Issues & implications for social work education & administrative practice are discussed. 2 Tables. Modified HA. JF - Journal of Education for Social Work AU - Scurfield, Raymond Monsour AD - Veterans Administration Medical Center, Los Angeles CA 90003 Y1 - 1980/01// PY - 1980 DA - January 1980 SP - 49 EP - 56 VL - 16 IS - 1 KW - optimal educational preparation KW - questionnaire survey KW - social work administrators KW - Preparation KW - Administration/Administrations/ Administrative/ Administrator/ Administrators KW - Social work KW - Education/Educational/Educator/ Educators/ Educationally KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61564891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Education+for+Social+Work&rft.atitle=Educational+Preparation+for+Social+Work+Administrators%3A+A+Survey&rft.au=Scurfield%2C+Raymond+Monsour&rft.aulast=Scurfield&rft.aufirst=Raymond&rft.date=1980-01-01&rft.volume=16&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+Education+for+Social+Work&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Education/Educational/Educator/ Educators/ Educationally; Social work; Administration/Administrations/ Administrative/ Administrator/ Administrators; Preparation ER - TY - JOUR T1 - The Organizational, Interactional and Care-Oriented Conditions for Patient Participation in Continuity of Care: A Framework for Staff Intervention AN - 61085373; 82M5125 AB - Based on data from a recently completed 2-year exploratory study, focus is on how specific organizational, interactional, & care-oriented factors in one clinical area provide a framework for guiding staff interventions toward furthering patient's participation. Even though these conditions were found on the "rehab" ward of the large acute care medical school-affiliated Veterans Administration hospital studied, they are not unique to it, & it is possible to generate them in other clinical contexts. Data were collected through field observations in selected clinical sites & in-depth interviews (numbers & details not provided). HA. JF - Social Science and Medicine AU - Davis, Marcella Z AD - San Diego Veterans Administration Medical Center, 3350 La Jolla Village Dr CA 92161 Y1 - 1980/01// PY - 1980 DA - January 1980 SP - 39 EP - 47 VL - 14A IS - 11 SN - 0277-9536, 0277-9536 KW - care continuity, patient participation, hospital staff intervention framework KW - organizational/interactional/care-oriented factors KW - Veterans Administration hospital, San Diego, California KW - Participate/Participatory/ Participation/ Participative KW - Patient/Patients KW - San Diego, Calif. KW - Continuity/Continuities/Continuous KW - Intervention KW - Staff/Staffing KW - Hospital/Hospitals KW - Treatment KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61085373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=The+Organizational%2C+Interactional+and+Care-Oriented+Conditions+for+Patient+Participation+in+Continuity+of+Care%3A+A+Framework+for+Staff+Intervention&rft.au=Davis%2C+Marcella+Z&rft.aulast=Davis&rft.aufirst=Marcella&rft.date=1980-01-01&rft.volume=14A&rft.issue=11&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Treatment; Continuity/Continuities/Continuous; Patient/Patients; Participate/Participatory/ Participation/ Participative; Staff/Staffing; Intervention; San Diego, Calif.; Hospital/Hospitals ER - TY - JOUR T1 - Tartan Turf registered on trial. A comparison of intercollegiate football injuries occurring on natural grass and Tartan Turf registered AN - 20750131; 10092303 AB - We retro- and prospectively compared collegiate football inju ries that occurred on the grass and Tartan Turf registered (3M Company, St. Paul, Minnesota) fields at the University of Wisconsin. Retrospective injury data were obtained from questionnaires returned by 235 of 450 athletes that competed from 1960 to 1973. Prospective injury data were obtained by examination of athletes injured from 1975 through 1977. Although the number of injuries occurring on each playing surface were not signifi cantly different, the type and severity of injuries were signifi cantly different. We found that significantly more serious sprains and torn ligaments occurred on grass than occurred on Tartan Turf registered . There were significantly more scrapes (minor injuries) on the Tartan Turf registered than on the grass. We conclude that we may be prematurely returning to natural grass playing surfaces, and-to the detriment of the athlete-ending produc tion of one synthetic turf that helped reduce major injuries. JF - American Journal of Sports Medicine AU - Keene, J S AU - Narechania, R G AU - Sachtjen, K M AU - Clancy, W G AD - Division of Orthopedic Surgery, Section of Sports Medicine, University of Wisconsin Center for Health Sciences, and Wm. S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin Y1 - 1980/01// PY - 1980 DA - Jan 1980 SP - 43 EP - 47 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 8 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Health & Safety Science Abstracts KW - Ligaments KW - Injuries KW - Grasses KW - Intercollegiate sports KW - turf KW - USA, Wisconsin KW - USA, Minnesota KW - sports related injuries KW - Evaluation KW - athletes KW - Surfaces KW - Higher education KW - Sprains KW - Sports medicine KW - Athletes KW - H 11000:Diseases/Injuries/Trauma KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20750131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Tartan+Turf+registered+on+trial.+A+comparison+of+intercollegiate+football+injuries+occurring+on+natural+grass+and+Tartan+Turf+registered&rft.au=Keene%2C+J+S%3BNarechania%2C+R+G%3BSachtjen%2C+K+M%3BClancy%2C+W+G&rft.aulast=Keene&rft.aufirst=J&rft.date=1980-01-01&rft.volume=8&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658000800108 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Evaluation; Ligaments; Injuries; Surfaces; Intercollegiate sports; Higher education; Sprains; Sports medicine; Athletes; sports related injuries; athletes; Grasses; turf; USA, Wisconsin; USA, Minnesota DO - http://dx.doi.org/10.1177/036354658000800108 ER - TY - JOUR T1 - Death Outlook and Social Issues AN - 1463015526; 82M4056 AB - The hypothesis that there is a relationship between outlook on death & orientation toward mercy killing, abortion, suicide, & euthanasia is examined. Multiple assessments of death outlook, in addition to such variables as religious orientation, life values, self-acceptance, & ethnic background, were used as predictors. Interview & test populations (total N = 616) included M alcoholics (N = 123), drug addicts (N = 115), prisoners (N = 92), deputy sheriffs (N = 143), & normal controls (N = 143). Major findings indicate some relationship between death attitudes & perspectives on the social issues being considered, & emphasize the need to consider specific circumstances as well as abstract concepts when dealing with social issues. 6 Tables. Modified HA. JF - Omega AU - Feifel, Herman AU - Schag, Daniel AD - Veterans Administration Outpatient Clinic, 425 South Hill St Los Angeles CA 90013 Y1 - 1980///0, PY - 1980 DA - 0, 1980 SP - 201 EP - 215 VL - 11 IS - 3 SN - 0030-2228, 0030-2228 KW - social issues orientation KW - death outlook KW - interviews KW - male alcoholics/drug addicts/prisoners/deputy sheriffs/normal controls KW - Death/Deaths (see also Mortality, Dying) KW - Male/Males (see also Man) KW - Drug addict/Drug addicts/Drug addiction (see also Addict) KW - Alcoholic/Alcoholics/Alcoholism KW - Issue/Issues KW - Social KW - Prison/Prisons/Prisoner/ Prisoners KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463015526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Omega&rft.atitle=Death+Outlook+and+Social+Issues&rft.au=Feifel%2C+Herman%3BSchag%2C+Daniel&rft.aulast=Feifel&rft.aufirst=Herman&rft.date=1980-01-01&rft.volume=11&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Omega&rft.issn=00302228&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - OMGABX N1 - SubjectsTermNotLitGenreText - Social; Issue/Issues; Death/Deaths (see also Mortality, Dying); Male/Males (see also Man); Alcoholic/Alcoholics/Alcoholism; Drug addict/Drug addicts/Drug addiction (see also Addict); Prison/Prisons/Prisoner/ Prisoners ER - TY - JOUR T1 - Deglutition Problems in Head and Neck Cancer Patients: Implications for the Speech Pathologist AN - 58084093; 8203447 AB - Patients with head & neck cancer frequently have swallowing impairment. Speech pathologists may overlook these patients unless there is an accompanying speech problem. The association of dysphagia & speech problems was evaluated in 58 cancer patients classified according to whether they had had total laryngectomy, supraglottic laryngectomy, or oral/pharyngeal resection. Ss in each group were evaluated 6 weeks postoperatively for any difficulties in speech, aspiration, or swallowing. Analyses substantiate the close interrelationship between speech & swallowing deficits. Recommendations for speech therapy are given. 1 Table. Modified HA JF - The British Journal of Disorders of Communication AU - Fleming, Susan M AU - Weaver, Arthur W AD - Veterans Administration Medical Center, Allen Park MI 48101 Y1 - 1979/12// PY - 1979 DA - December 1979 SP - 241 EP - 245 VL - 14 IS - 3 SN - 0007-098X, 0007-098X KW - speech difficulty, head/neck cancer patients KW - speech/swallowing deficit relationships KW - Speech Pathology (sp5) KW - Laryngectomy (la11) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58084093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Disorders+of+Communication&rft.atitle=Deglutition+Problems+in+Head+and+Neck+Cancer+Patients%3A+Implications+for+the+Speech+Pathologist&rft.au=Fleming%2C+Susan+M%3BWeaver%2C+Arthur+W&rft.aulast=Fleming&rft.aufirst=Susan&rft.date=1979-12-01&rft.volume=14&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Disorders+of+Communication&rft.issn=0007098X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJDCBU N1 - SubjectsTermNotLitGenreText - Speech Pathology (sp5); Laryngectomy (la11) ER - TY - JOUR T1 - Health Status, Room Size, and Activity Level. Research in an Institutional Setting AN - 20802996; 10903211 AB - The relationship of actual and perceived health to each other and to levels of activity, and the effects of perceived health and the number of occupants in a room on activity level, were the primary concerns of this study. It was found that while both the actual and perceived health measures were positively correlated with activity, only the actual health measures entered the multiple regression analysis as significant predictors of activity. However, using a 4 (room size) x 2 (perceived health) analysis of covariance, controlling for age and actual health status, it was found that there was a significant main effect for perceived health and a significant interaction effect. There was also evidence that the relationship of number of occupants in a room to activity may be curvilinear rather than linear, as originally hypothesized. JF - Environment & Behavior AU - Nehrke, Milton F AU - Morganti, John B AU - Willrich, Ruth AU - Hulicka, Irene M AD - Veterans Administration Center, Bath, New York Y1 - 1979/12// PY - 1979 DA - Dec 1979 SP - 451 EP - 463 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 11 IS - 4 SN - 0013-9165, 0013-9165 KW - Environment Abstracts; Environmental Engineering Abstracts KW - Age KW - Perception KW - EE 10:General Environmental Engineering KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20802996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+%26+Behavior&rft.atitle=Health+Status%2C+Room+Size%2C+and+Activity+Level.+Research+in+an+Institutional+Setting&rft.au=Nehrke%2C+Milton+F%3BMorganti%2C+John+B%3BWillrich%2C+Ruth%3BHulicka%2C+Irene+M&rft.aulast=Nehrke&rft.aufirst=Milton&rft.date=1979-12-01&rft.volume=11&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Environment+%26+Behavior&rft.issn=00139165&rft_id=info:doi/10.1177%2F0013916579114002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Perception; Age DO - http://dx.doi.org/10.1177/0013916579114002 ER - TY - JOUR T1 - The Relation between Gesture and Language in Aphasic Communication AN - 85442809; 8104670 AB - Anterior & posterior aphasics (N = 2 each) & controls (N = 4) were videotaped during an informal interview. Three aspects of gesture communication were examined: (1) physical parameters, (2) temporal location of "syntax," & (3) semantic & pragmatic characteristics. The same general properties appeared in both speech & gestures of aphasic Ss. For the anterior aphasics, simple & generally clear output was found, although limited in quantity. Posterior aphasics showed considerable gesturing, much of which was complex. Most gesturing was nonreferential & often unclear. The major difference between posterior aphasics & normal controls occurred in clarity. Speech carried the majority of communication information for both aphasic groups. It is suggested that independently, aphasics are not very successful at overcoming communication deficits & do not spontaneously use gesture to compensate. This may be either because both speech & gesture are controlled by a single "central organizer," or because gesture depends directly on lang. 5 Tables. B. Annesser JF - Brain and Language AU - Cicone, Michael AU - Wapner, Wendy AU - Foldi, Nancy S AU - Zurif, Edgar AU - Gardner, Howard AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1979/11// PY - 1979 DA - November 1979 SP - 324 EP - 349 VL - 8 IS - 3 SN - 0093-934X, 0093-934X KW - gesturing, anterior vs posterior aphasics KW - Syntax (sy3) KW - Semantics (se9) KW - Language Pathology (la4) KW - Pragmatics (pq1) KW - Nonverbal Communication (no4a) KW - Aphasia (ap1) KW - article KW - 5810: nonverbal communication; human nonverbal language KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85442809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Relation+between+Gesture+and+Language+in+Aphasic+Communication&rft.au=Cicone%2C+Michael%3BWapner%2C+Wendy%3BFoldi%2C+Nancy+S%3BZurif%2C+Edgar%3BGardner%2C+Howard&rft.aulast=Cicone&rft.aufirst=Michael&rft.date=1979-11-01&rft.volume=8&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Nonverbal Communication (no4a); Syntax (sy3); Semantics (se9); Pragmatics (pq1) ER - TY - JOUR T1 - Left-to-Right Transfer of Language Dominance: A Case Study AN - 85440358; 8103258 AB - Partial recovery from aphasia is documented in a 54-year-old, right-handed M rendered hemiplegic & globally aphasic by embolic infarction in the distribution of the left-middle cerebral artery. Computed tomography showed total destruction of the classical left hemisphere language areas, indicating that the right hemisphere was responsible for the improved linguistic function. This is consistent with right hemisphere language capacity demonstrated after left hemispherectomy or commissurotomy. Right hemisphere lang function may underlie much of the recovery from aphasia after injury of the left hemisphere. 1 Table, 1 Figure. HA JF - Neurology AU - Cummings, Jeffrey L AU - Benson, D Frank AU - Walsh, Michael J AU - Levine, Harvey L AD - Neurobehavioral Center Boston Veterans Administration Medical Center, MA 02130 Y1 - 1979/11// PY - 1979 DA - November 1979 SP - 1547 EP - 1550 VL - 29 IS - 11 SN - 0028-3878, 0028-3878 KW - right hemisphere language function, left-hemisphere-destroyed aphasic's partial recovery KW - 54-year-old male KW - Neurolinguistics (ne3a) KW - Brain Anatomy (br1) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85440358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Left-to-Right+Transfer+of+Language+Dominance%3A+A+Case+Study&rft.au=Cummings%2C+Jeffrey+L%3BBenson%2C+D+Frank%3BWalsh%2C+Michael+J%3BLevine%2C+Harvey+L&rft.aulast=Cummings&rft.aufirst=Jeffrey&rft.date=1979-11-01&rft.volume=29&rft.issue=11&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Aphasia (ap1); Brain Anatomy (br1) ER - TY - JOUR T1 - A Note on Temporal Relations between Language and Gestures AN - 85438526; 8104534 AB - The temporal relation between spontaneous gesture & semantic content shifts across sentence syntactic boundaries was examined. It was hypothesized that spontaneous gestures would occur at the outset of embedded constructions which were semantically discontinuous with the main clause. Ss (2 posterior aphasics & 2 normal controls) were videotaped during informal interviews. Sentences containing two or more deep structure propositions & accompanied by spontaneous gesturing were selected for analysis. Overall, the hypothesis was confirmed. Results have implications for diagnosis of Wernicke's aphasia, since the inability of such patients to maintain coherent thought across syntactic boundaries apparently manifests itself in their spontaneous gesturing. 1 Table. B. Annesser JF - Brain and Language AU - Delis, Dean AU - Foldi, Nancy S AU - Hamby, Suzanne AU - Gardner, Howard AU - Zurif, Edgar AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1979/11// PY - 1979 DA - November 1979 SP - 350 EP - 354 VL - 8 IS - 3 SN - 0093-934X, 0093-934X KW - spontaneous gesture/speech semantic content relationship KW - posterior aphasics KW - Deep Structure and Surface Structure (de3) KW - Semantics (se9) KW - Aphasia (ap1) KW - Nonverbal Communication (no4a) KW - Embedded Construction (em1) KW - article KW - 5810: nonverbal communication; human nonverbal language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85438526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=A+Note+on+Temporal+Relations+between+Language+and+Gestures&rft.au=Delis%2C+Dean%3BFoldi%2C+Nancy+S%3BHamby%2C+Suzanne%3BGardner%2C+Howard%3BZurif%2C+Edgar&rft.aulast=Delis&rft.aufirst=Dean&rft.date=1979-11-01&rft.volume=8&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Nonverbal Communication (no4a); Semantics (se9); Embedded Construction (em1); Deep Structure and Surface Structure (de3); Aphasia (ap1) ER - TY - JOUR T1 - The Utility of Natural Help Relationships AN - 61570618; 198100466 AB - Research pertinent to network analysis is explored, & its use as a necessary method of medical sociology substantiated. The concept of social support relfects a type of influence or resource derived from network relationships. Certain aspects of social support are seen as critical to the functioning & adaptation of the individual, especially in times of crisis when supportive relationships can mediate the effects of stress. A theory of mutual aid investment is proposed based on sociomatrix analysis. Examined is the relationship between the availability & nature of particular social support networks & the willingness & capability of the individual to use them. Interviews with 137 residents of 9 small areas near central Seattle revealed that the function of mutual aid among neighbors varies according to type of crisis, age, & structure of the mutual aid chain, & as a product of neighborhood characteristics. 4 Tables, 1 Figure. Modified HA. JF - Social Science and Medicine AU - Evans, Ron L AU - Northwood, Lawrence K AD - Veterans Administration Medical Center, Seattle WA 98108 Y1 - 1979/11// PY - 1979 DA - November 1979 SP - 789 EP - 795 VL - 13A IS - 6 SN - 0277-9536, 0277-9536 KW - individual functioning/adaptation KW - social support networks, natural help relationships KW - interviews KW - Seattle, Washington, neighborhood residents KW - Social network/Social networks/Social networking KW - Help/Helping/Helper/Helpers KW - Support/Supports/Supported/ Supporting/ Supportive KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61570618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=The+Utility+of+Natural+Help+Relationships&rft.au=Evans%2C+Ron+L%3BNorthwood%2C+Lawrence+K&rft.aulast=Evans&rft.aufirst=Ron&rft.date=1979-11-01&rft.volume=13A&rft.issue=6&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Help/Helping/Helper/Helpers; Social network/Social networks/Social networking; Support/Supports/Supported/ Supporting/ Supportive ER - TY - JOUR T1 - Time for Auditory Processing of Object Names by Aphasics AN - 58068759; 8104663 AB - Investigated was whether impaired auditory comprehension in aphasia was reflected in a lengthened time for semantic decoding of individual substantives. Ss were aphasics (N = 10 Broca's & 10 Wernicke's) & nonaphasic controls (N = 20). Mean auditory processing time for Broca's aphasics was approximately 200 milliseconds (msec), Wernicke's aphasics 650 msec. Broca's aphasics were not significantly slower than normal controls. Moreover, within the Wernicke group there was a significant r between the number of failed identifications & the decoding time for correctly identified targets. The other groups had too few failures to test this relationship. Thus, it appears that aphasia not only entails slowed processing of elementary acoustic segments & of word strings, but, at least in the case of Wernicke's aphasics, slowed processing at the single word level as well. 4 Tables, 1 Figure. Modified HA JF - Brain and Language AU - Baker, Errol AU - Goodglass, Harold AD - Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1979/11// PY - 1979 DA - November 1979 SP - 355 EP - 366 VL - 8 IS - 3 SN - 0093-934X, 0093-934X KW - semantic decoding time KW - Broca's vs Wernicke's aphasics KW - Listening Comprehension (li4) KW - Psycholinguistics (ps3) KW - Semantics (se9) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Time+for+Auditory+Processing+of+Object+Names+by+Aphasics&rft.au=Baker%2C+Errol%3BGoodglass%2C+Harold&rft.aulast=Baker&rft.aufirst=Errol&rft.date=1979-11-01&rft.volume=8&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Pathology (la4); Listening Comprehension (li4); Psycholinguistics (ps3); Semantics (se9) ER - TY - JOUR T1 - Word Association: Capacity of Chronic Schizophrenics to Follow Formal Semantic, Syntactic, and Instructional Rules AN - 85451533; 8205186 AB - Free word associations with pressure for fast response were compared for actively psychotic but tranquil chronic schizophrenics (N = 50, paranoid & simple) & closely matched hospital employees (N = 50). Stimulus words were homonyms equated, among other factors, for availability of responses in the various response tendencies characterized as idiodynamic sets, eg, to define or explain the response, or to give a syntactic response. Comprehensive scoring schemata included separate semantic-syntactic, grammatical, & affective dimensions. Qualitatively, both groups had similar aberrant or faulting behavior, but schizophrenics gave significantly more of three kinds of faults: (1) failure to follow instructions (no response, repeating the stimulus, giving a multiword); (2) mishearing the stimulus (response distant to the intended stimulus but closely related to a phonetically similar word); & (3) distant experiential relationships (eg, pan-knife). On the % of scorable responses, the qualitative nature of nonfaulted responses of all three groups was indistinguishable. Schizophrenics had intact associative structures that appeared to be organized & used in the same way as those of controls. 2 Tables, 1 Figure. HA JF - Psychological Reports AU - Mefferd, Roy B, Jr AD - Veterans Administration Medical Center, 2002 Holcombe Blvd Houston TX 77211 Y1 - 1979/10// PY - 1979 DA - October 1979 SP - 431 EP - 442 VL - 45 IS - 2 SN - 0033-2941, 0033-2941 KW - word association, fast response pressure KW - homonyms, syntactic /semantic/grammatical/affective scoring dimensions KW - paranoid /simple schizophrenics, normals KW - Schizophrenia (sc1) KW - Psychotic Disorders (ps4) KW - Word and Letter Association (wo2) KW - article KW - 6710: linguistics and psychiatry; linguistics and psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85451533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Word+Association%3A+Capacity+of+Chronic+Schizophrenics+to+Follow+Formal+Semantic%2C+Syntactic%2C+and+Instructional+Rules&rft.au=Mefferd%2C+Roy+B%2C+Jr&rft.aulast=Mefferd&rft.aufirst=Roy&rft.date=1979-10-01&rft.volume=45&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Word and Letter Association (wo2); Schizophrenia (sc1); Psychotic Disorders (ps4) ER - TY - JOUR T1 - Word Association and Formal Training of the Written Language: Consolidation of the Response Base AN - 85447779; 8203694 AB - Commonalities of adult word associations with 659 stimulus words (data taken from 3 previous studies) were examined as a function of the elementary school grade level at which the words are formally introduced in their written form. There was a systematic decrease in commonality of associates as a function of grade level of introduction. A random sample of 20 words from each grade level showed that 64% of the primary responses to these words had been introduced in written form before grade 2. Associations of children in kindergarten through grade 5 (N = at least 30 in each group) were obtained to 70 of the 659 words, drawn from kindergarten through grade 6. Three significant effects of commonality appeared: (1) words introduced in grade 2 had the highest commonalities regardless of grade level of S; (2) the commonality of a word had a tendency to increase in the grade when it was introduced; & (3) the commonality of a given word increased at each succeeding grade level even though the children's vocabulary was rapidly expanding. Commonalities observed for children & adults are discussed in terms of time & manner of formal introduction of the written words. 4 Tables, 4 Figures. HA JF - Psychological Reports AU - Mefferd, Roy B, Jr AU - Dufilho, Joanne H AU - Dawson, Nancy E AD - Veterans Administration Medical Center, Houston TX 77211 Y1 - 1979/10// PY - 1979 DA - October 1979 SP - 615 EP - 628 VL - 45 IS - 2 SN - 0033-2941, 0033-2941 KW - word association commonalities, differing grade levels of written form introduction KW - kindergarten-sixth grade level words KW - kindergarten-fifth graders KW - Word and Letter Association (wo2) KW - Age Differences in Language (ag1) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85447779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Word+Association+and+Formal+Training+of+the+Written+Language%3A+Consolidation+of+the+Response+Base&rft.au=Mefferd%2C+Roy+B%2C+Jr%3BDufilho%2C+Joanne+H%3BDawson%2C+Nancy+E&rft.aulast=Mefferd&rft.aufirst=Roy&rft.date=1979-10-01&rft.volume=45&rft.issue=2&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Word and Letter Association (wo2); Age Differences in Language (ag1) ER - TY - JOUR T1 - The Mental Health Movement, 1949-1979 AN - 61100838; 81L5217 AB - Three decades (ending in 1978/79) of social experimentation in caring for the mentally ill have yielded many new programs, treatments, personnel, & facilities. Despite administrative complexities & historical divisions, alternatives are already available in general hospitals as well as in community centers. Future policies & priorities will not be clarified through unrealistic medical models, but would do well to focus on early detection & treatment. Concern is expressed that the recent trend toward balancing the budget by cutting services not halt recent progress in social & health programs. Modified HA. JF - Milbank Memorial Fund Quarterly/Health and Society AU - Ewalt, Jack R AD - Mental Health & Behavioral Sciences Service US Veterans Administration Central Office, Washington DC 20420 Y1 - 1979/10// PY - 1979 DA - October 1979 SP - 507 EP - 515 VL - 57 IS - 4 KW - mental health movement, 1949-1979 KW - future budget-cutting trends KW - Mental health KW - Movement/Movements KW - article KW - 0826: mass phenomena; social movements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61100838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Milbank+Memorial+Fund+Quarterly%2FHealth+and+Society&rft.atitle=The+Mental+Health+Movement%2C+1949-1979&rft.au=Ewalt%2C+Jack+R&rft.aulast=Ewalt&rft.aufirst=Jack&rft.date=1979-10-01&rft.volume=57&rft.issue=4&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Milbank+Memorial+Fund+Quarterly%2FHealth+and+Society&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - MMFQAJ N1 - SubjectsTermNotLitGenreText - Mental health; Movement/Movements ER - TY - JOUR T1 - Word Association: Grammatical, Semantic, and Affective Dimensions of Associates to Homonyms AN - 58124142; 8203695 AB - Scoring schemata of word associations for grammatical forms, & affective & semantic-syntactic associates were developed using factor analyses. The schemata were developed over a period of twenty years using hundreds of ambiguous words & thousands of Ss in both normal & patient categories. Also presented are factor structures obtained from presentation to 100 adult Ms with high school education. Interactions between those dimensions relating to the organization & size of associative networks, & several nomothetic & psychometric variables, are discussed. Virtually no cross-over between the affective & semantic associative networks appears to exist. A significant difference occurs, however, in the faulting behaviors with the two networks. 4 Tables. HA JF - Psychological Reports AU - Mefferd, Roy B, Jr AD - Veterans Administration Medical Center, 2002 Holcombe Blvd Houston TX 77211 Y1 - 1979/10// PY - 1979 DA - October 1979 SP - 359 EP - 374 VL - 45 IS - 2 SN - 0033-2941, 0033-2941 KW - word association scoring schemata, factor analysis KW - affective vs semantic associative networks KW - Word and Letter Association (wo2) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58124142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Word+Association%3A+Grammatical%2C+Semantic%2C+and+Affective+Dimensions+of+Associates+to+Homonyms&rft.au=Mefferd%2C+Roy+B%2C+Jr&rft.aulast=Mefferd&rft.aufirst=Roy&rft.date=1979-10-01&rft.volume=45&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Word and Letter Association (wo2) ER - TY - JOUR T1 - Differences by Sex and Ethnicity in the Psychosocial Adjustment of the Elderly AN - 60677350; 80K6757 AB - Elderly males & females from white, black, & Cuban groups were studied in terms of their psychosocial adjustment using data from people (number of cases = 283) attending the general medical outpatient clinic of a large University & county hospital located in Miami, Fla collected during 1976-1978. Essentially no sex differences were found in overall adjustment although strong cultural differences were observed. Elderly blacks showed the best adjustment when social class & level of disability were held constant. Disability had more of an effect on level of adjustment than did social class. Cubans showed the most negative adjustment, most likely due to their cultural displacement from Cuba. The fact that many whites in the sample were also 'displaced persons,' having moved from other areas of the country to Miami when they retired, & the fact that most of the blacks were natives may account for the black elderly having the best overall adjustment. 5 Tables. Modified HA. JF - Journal of Health and Social Behavior AU - Linn, Margaret W AU - Hunter, Kathleen I AU - Perry, Priscilla R AD - Veterans Administration Hospital, Miami FL 33125 Y1 - 1979/09// PY - 1979 DA - September 1979 SP - 273 EP - 281 VL - 20 IS - 3 SN - 0022-1465, 0022-1465 KW - elderly, psychosocial adjustment, sex/ethnicity/disability KW - medical outpatient clinic, Miami, 1976-1978 KW - Psycho KW - Elder/Elders/Elderly KW - Ethnicity/Ethnicism KW - Sex/Sexes/Sexism/Sexist/Sexists KW - Social KW - Adjustment/Adjustments KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60677350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+and+Social+Behavior&rft.atitle=Differences+by+Sex+and+Ethnicity+in+the+Psychosocial+Adjustment+of+the+Elderly&rft.au=Linn%2C+Margaret+W%3BHunter%2C+Kathleen+I%3BPerry%2C+Priscilla+R&rft.aulast=Linn&rft.aufirst=Margaret&rft.date=1979-09-01&rft.volume=20&rft.issue=3&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+and+Social+Behavior&rft.issn=00221465&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JHSBA5 N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Psycho; Social; Adjustment/Adjustments; Sex/Sexes/Sexism/Sexist/Sexists; Ethnicity/Ethnicism ER - TY - JOUR T1 - Local cerebral metabolism during enflurane anesthesia: identification of epileptogenic foci. AN - 75026441; 95709 AB - Electrocorticographic (ECoG) and depth recordings have previously demonstrated the epileptogenic nature of surgical concentrations of the volatile anesthetic enflurane. We contrasted ECoG activity with local cerebral glucose uptake [( 14C]2-deoxyglucose autoradiography) in 23 brain structures in order to identify the epileptogenic foci. Autoradiograms were obtained from sectioned rat brain following a 30 min period of steady-state anesthesia at 1, 1.5, or 2 MAC (minimum alveolar concentration) enflurane. Pseudo-epileptiform ECoGs were obtained at 1 MAC where bursts of slow waves and sharp waves were evoked by peripheral sensory stimulation. At 1.5 MAC, the ECoG displayed frank, spontaneous epileptiform activity with large amplitude spike-wave complexes; repetitive auditory stimulation occasionally precipitated grand-mal seizures. At 2 MAC, spike complexes were less frequent and could not be repetitively driven. At 1 MAC enflurane, regional cerebral metabolism was generally depressed approximately 14% from the awake controls. However, metabolism in the dentate gyrus of the hippocampus and other subcortical structures in the limbic brain was increased. At 1.5 MAC this dichotomy in local cerebral metabolic rate was maximal; we observed increased metabolism in the hippocampus, habenula, habenulo-interpeduncular tract and interpeduncular nucleus and pineal. Metabolism in all other structures was significantly depressed (P less than 0.05) compared to awake values. At 2 MAC, metabolism was decreased in all structures. We conclude that the low seizure threshold hippocampus and related structures associated with the limbic system and its pathways are the epileptogenic foci for seizures induced with enflurane in the rat. At 1.5 MAC, epileptiform activity spreads throughout the visceral brain when seizure threshold is at a minimum. JF - Electroencephalography and clinical neurophysiology AU - Myers, R R AU - Shapiro, H M AD - Department of Anesthesiology, Veterans Administration Hospital, San Diego, Calif. Y1 - 1979/08// PY - 1979 DA - August 1979 SP - 153 EP - 162 VL - 47 IS - 2 SN - 0013-4694, 0013-4694 KW - Enflurane KW - 91I69L5AY5 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Glucose -- metabolism KW - Electrocardiography KW - Tissue Distribution KW - Autoradiography KW - Male KW - Female KW - Cerebral Cortex -- physiopathology KW - Epilepsy -- physiopathology KW - Epilepsy -- chemically induced KW - Enflurane -- adverse effects KW - Anesthesia, General KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75026441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electroencephalography+and+clinical+neurophysiology&rft.atitle=Local+cerebral+metabolism+during+enflurane+anesthesia%3A+identification+of+epileptogenic+foci.&rft.au=Myers%2C+R+R%3BShapiro%2C+H+M&rft.aulast=Myers&rft.aufirst=R&rft.date=1979-08-01&rft.volume=47&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Electroencephalography+and+clinical+neurophysiology&rft.issn=00134694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-14 N1 - Date created - 1990-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Organizational Theory and Cultural Intrusions into Organizations AN - 60644693; 80K5865 AB - The conclusions that J. R. Lincoln, J. Olson, & M. Hanada reach concerning the influence of Japanese culture on Japanese firms located in the United States (see SA 27:4/K1374) seem inconclusive & unclear. The point made concerning the inadequacies of rationalistic theories of organization can be clarified considerably; models need to be developed concerning the interrelations between the surrounding culture & a wider range of organizational structural features. Organizations are open systems of a special kind which have ways to control the intrusions of a surrounding culture. In Reply to Katz, J. R. Lincoln, J. Olson, & M. Hanada (Indiana University, Bloomington, University of Southern Calif, Los Angeles & institutions of Business Administration & Management, Tokyo Japan) agree that employees are able to 'import' & 'export' cultural values across organizational boundaries but do not find this notion very illuminating. It does not seem that further consideration of the autonomy question would have changed the results. M. Migalski. JF - American Sociological Review AU - Katz, Fred E AD - Health Services Center Veterans Administration Medical Center, Perry Point MD 21092 Y1 - 1979/08// PY - 1979 DA - August 1979 SP - 667 EP - 668 VL - 44 IS - 4 SN - 0003-1224, 0003-1224 KW - Japanese firms/US, organizational structure, cultural influences KW - J. Lincoln's et al 'Cultural Effects on Organizational Structure,' criticism KW - reply KW - Culture/Cultures/Cultural/ Culturally KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - Japan/Japanese KW - United States/US KW - Firm/Firms KW - article KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60644693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Sociological+Review&rft.atitle=Organizational+Theory+and+Cultural+Intrusions+into+Organizations&rft.au=Katz%2C+Fred+E&rft.aulast=Katz&rft.aufirst=Fred&rft.date=1979-08-01&rft.volume=44&rft.issue=4&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=American+Sociological+Review&rft.issn=00031224&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - SuppNotes - Reply, 668. N1 - Last updated - 2016-09-28 N1 - CODEN - ASREAL N1 - SubjectsTermNotLitGenreText - United States/US; Japan/Japanese; Firm/Firms; Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing; Culture/Cultures/Cultural/ Culturally ER - TY - JOUR T1 - Management of Palilalia with a Pacing Board AN - 58082160; 8201856 AB - Palilalia, a speaking disorder, has been likened to the festinating gait of Parkinsonian patients. Described is a pacing device developed as a means of controlling the severely palilalic output of one patient. The device is modeled after A. R. Luria's suggestion (Traumatic Aphasia, The Hague: Mouton, 1967) that a treatment program for such patients can be developed successfully by transferring automatic motor acts to a conscious, reactive level. 1 Figure. Modified HA JF - Journal of Speech and Hearing Disorders AU - Helm, Nancy A AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1979/08// PY - 1979 DA - August 1979 SP - 350 EP - 353 VL - 44 IS - 3 KW - palilalia, controlling device, treatment program KW - Speech Pathology (sp5) KW - Speech Therapy (sp13) KW - Articulation (ar3) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58082160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Management+of+Palilalia+with+a+Pacing+Board&rft.au=Helm%2C+Nancy+A&rft.aulast=Helm&rft.aufirst=Nancy&rft.date=1979-08-01&rft.volume=44&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Speech Pathology (sp5); Articulation (ar3); Speech Therapy (sp13) ER - TY - JOUR T1 - Word Association: Verbal Intelligence AN - 58109799; 8203595 AB - Examined was the r of verbal intelligence & word association - a relationship that has only occasionally been shown significant. Problems involved in formulating effective studies of the relationship are outlined. A test is reported in which Ss received only homonyms equated for commonality & familiarity (groups 1-3), a list of 30 nonhomonym Kent-Rosanoff words scattered among homonyms (group 4), or a larger list over a period of days containing 100 Kent-Rosanoff words (group 5). Group 1 consisted of controls & schizophrenics (N = 100 each), group 2 of airmen (N = 117), group 3 of adults (N = 100), group 4 of Coll students (N = 100), & group 5 hospital patients (N = 196). Ethnic background of Ss (white, black, or Chicano) was also considered. Three varimax factors in which verbal intelligence loaded were identified; only paradigmatic associates loaded on these factors. Although they were negatively correlated with intelligence, syntagmatic associates formed no cohesive pattern of common variance with intelligence. The relationships were not apparent from the familiar unambiguous words of the Kent-Rosanoff list, but were found for highly familiar ambiguous words with many meanings. In adults the type, extent of, & persistence of the childhood syntagmatic to paradigmatic shifts appears to be a function of verbal intelligence. 4 Tables. Modified HA JF - Psychological Reports AU - Mefferd, Roy B, Jr AD - Veterans Administration Medical Center, Houston TX 77211 Y1 - 1979/06// PY - 1979 DA - June 1979 SP - 919 EP - 924 VL - 44 IS - 3 SN - 0033-2941, 0033-2941 KW - verbal intelligence/word association relationship KW - Kent-Rosanoff words KW - adults/undergraduates/schizophrenics/airmen/hospital patients, white/black/Chicano KW - Schizophrenia (sc1) KW - Sociolinguistics (so2) KW - Ethnolinguistics (et2) KW - Intelligence Testing (in9) KW - Paired Associate Learning (pa1) KW - Age Differences in Language (ag1) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58109799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Word+Association%3A+Verbal+Intelligence&rft.au=Mefferd%2C+Roy+B%2C+Jr&rft.aulast=Mefferd&rft.aufirst=Roy&rft.date=1979-06-01&rft.volume=44&rft.issue=3&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Paired Associate Learning (pa1); Intelligence Testing (in9); Age Differences in Language (ag1); Ethnolinguistics (et2); Schizophrenia (sc1); Sociolinguistics (so2) ER - TY - JOUR T1 - Verbal Conditioning and Extinction of the GSR Index of the Orienting Reflex AN - 58074990; 8004655 AB - A two-component theory of classical conditioning of the galvanic skin response (GSR) asserts that one component is mediated by cognitive expectancies whereas an unmediated emotional component is also present when a highly noxious UCS is employed. Evidence for the unmediated emotional component stems from studies reporting considerable resistance to extinction despite prior instructions informing participants that the UCS would no longer occur. Unmediated conditioned emotional responses persist contrary to cognitive expectancies. A forewarned reaction time procedure with an innocuous imperative stimulus was used to test the two-component theory (N = 96). Significant differential resistance to extinction was found in groups of instructed Ss where conditioned responses were contrary to cognitive expectancies. Conditioned responses contrary to cognitive expectancies need not reflect unmediated emotional responses. 1 Table, 2 Figures. HA JF - Physiological Psychology AU - Pendery, Mary AU - Maltzman, Irving AD - Veterans Administration Hospital, San Diego CA 92161 Y1 - 1979/06// PY - 1979 DA - June 1979 SP - 185 EP - 192 VL - 7 IS - 2 KW - galvanic skin response extinction KW - cognitive, emotional components KW - Cognate (co1) KW - Psycholinguistics (ps3) KW - Evoked Response (ev1) KW - Conditioning (co11) KW - Emotion (em2) KW - article KW - 4010: psycholinguistics; psycholinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58074990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+Psychology&rft.atitle=Verbal+Conditioning+and+Extinction+of+the+GSR+Index+of+the+Orienting+Reflex&rft.au=Pendery%2C+Mary%3BMaltzman%2C+Irving&rft.aulast=Pendery&rft.aufirst=Mary&rft.date=1979-06-01&rft.volume=7&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Physiological+Psychology&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PLPSAX N1 - SubjectsTermNotLitGenreText - Psycholinguistics (ps3); Cognate (co1); Emotion (em2); Evoked Response (ev1); Conditioning (co11) ER - TY - JOUR T1 - Spectral versus Temporal Features in Dichotic Listening AN - 58103762; 8101695 AB - Experiments were conducted to discover the critical acoustic-phonetic features of speech which might cause a person with left-ear dominance (LED) for pitch to show a right-ear advantage (REA) for speech sounds. A two-alternative forced-choice paradigm was used. Stimuli consisted of sounds A & B. In 50% of the trials, A was presented in the left ear, followed by B in the right ear. This order was reversed in the other 50%. Ss (N = 3 F, 3 M adults) were required to indicate whether the series sounded more like A-B or B-A. In experiment 1, sounds A & B were a pairs of pure tones; in experiment 2, they were 1 pair of single formant pseudo-vowels, 3 pairs of 4-formant vowels, & 2 pairs of cons-vowel syllables. One S was LED for pitch & showed LEA for pseudo-vowels & vowels differing only in second formant, but showed REA for vowels where most spectral information was carried in first formant. Four additional vowel pairs were tested with this S in experiment 3. It was found that a S who is RED for the processing of spectral information is likely to show REA for any pair of speech sounds. Those who are LED for spectral information will retain this dominance for speech sounds differing only in spectral characteristics, but will show REA for speech sounds differing in temporal characteristics. 2 Tables. B. Annesser JF - Brain and Language AU - Divenyi, Pierre L AU - Efron, Robert AD - Veterans Administration Medical Center, Martinez CA 94553 Y1 - 1979/05// PY - 1979 DA - May 1979 SP - 375 EP - 386 VL - 7 IS - 3 SN - 0093-934X, 0093-934X KW - pure tone, pseudo-vowels, vowel perception KW - spectral vs temporal sound characteristics KW - left-ear dominant adults KW - Vowel (vo4) KW - Speech Perception (sp6) KW - Tone (to1) KW - Psychoacoustics (ps1) KW - Binaural Stimulation (bi2) KW - Pitch (pi2) KW - article KW - 4017: psycholinguistics; psychoacoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58103762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Spectral+versus+Temporal+Features+in+Dichotic+Listening&rft.au=Divenyi%2C+Pierre+L%3BEfron%2C+Robert&rft.aulast=Divenyi&rft.aufirst=Pierre&rft.date=1979-05-01&rft.volume=7&rft.issue=3&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Psychoacoustics (ps1); Speech Perception (sp6); Pitch (pi2); Tone (to1); Vowel (vo4); Binaural Stimulation (bi2) ER - TY - JOUR T1 - Visual Imagery vs. Semantic Category as Encoding Conditions AN - 58080083; 8200018 AB - Semantic encoding was directly compared to visual imagery encoding in an experimental variant of the Craik-Tulving procedure. Sixty words were presented orally in 1 of 5 encoding conditions: 2 from F. Craik's & E. Tulving's experiment 9 ([see LLBA, X/2, 761000], semantic category/yes & semantic category/no), & 3 imagery encoding conditions (single image/good, single image/bad, & interactive word pair imagery). Coll students (N = 30) indicated that imagery encoding gave better immediate recognition than did deep semantic encoding. Recognition scores differed little within imagery conditions, but within semantic conditions, semantic category/yes gave higher scores than semantic category/no. Results indicate further study is needed. 1 Table. HA JF - The Bulletin of the Psychonomic Society AU - Crovitz, Herbert F AU - Harvey, Michael T AD - Veterans Administration Hospital, Durham NC 27705 Y1 - 1979/05// PY - 1979 DA - May 1979 SP - 291 EP - 292 VL - 13 IS - 5 SN - 0090-5054, 0090-5054 KW - semantic vs visual imagery word encoding KW - oral presentation, Craik-Tulving procedure variaton, five encoding conditions KW - Psycholinguistics (ps3) KW - Imagery (im1) KW - Semantics (se9) KW - Cognitive Processes (co1b) KW - Verbal Learning (ve2) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58080083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Bulletin+of+the+Psychonomic+Society&rft.atitle=Visual+Imagery+vs.+Semantic+Category+as+Encoding+Conditions&rft.au=Crovitz%2C+Herbert+F%3BHarvey%2C+Michael+T&rft.aulast=Crovitz&rft.aufirst=Herbert&rft.date=1979-05-01&rft.volume=13&rft.issue=5&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=The+Bulletin+of+the+Psychonomic+Society&rft.issn=00905054&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BPNSBY N1 - SubjectsTermNotLitGenreText - Cognitive Processes (co1b); Imagery (im1); Psycholinguistics (ps3); Semantics (se9); Verbal Learning (ve2) ER - TY - JOUR T1 - A Study of Spelling in Aphasia AN - 58069647; 8103135 AB - Right-handed aphasic patients (N = 31) served as Ss in a study of spelling abilities in aphasia. Of these, 14 were anterior aphasics, 11 were posterior aphasics, & 6 exhibited mixed aphasia. Stimuli consisted of 25 objects whose names represented 5 orthographic categories of word type. Objects were presented under 4 conditions to each S. In the first 3 conditions, the patient was asked to spell the name of the object either orally, in writing, or using a set of blocks. In the fourth condition, Ss were asked to name the object aloud. Results indicated spelling performance consistent with the state of other linguistic abilities. Modality of response had no significant effect, except in the case of anterior aphasics. Some differences between the groups in errors made & strategies adopted were noted. It is suggested that there are two approaches to spelling which may be dissociated in brain-damaged adults. 1 Table, 3 Figures. B. Annesser JF - Brain and Language AU - Wapner, Wendy AU - Gardner, Howard AD - Veterans Administration Hospital, Boston MA 02130 Y1 - 1979/05// PY - 1979 DA - May 1979 SP - 363 EP - 374 VL - 7 IS - 3 SN - 0093-934X, 0093-934X KW - spelling ability KW - linguistic ability, response modality KW - anterior, posterior, mixed right-handed aphasics KW - Language Pathology (la4) KW - Aphasia (ap1) KW - Orthography (or5) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58069647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=A+Study+of+Spelling+in+Aphasia&rft.au=Wapner%2C+Wendy%3BGardner%2C+Howard&rft.aulast=Wapner&rft.aufirst=Wendy&rft.date=1979-05-01&rft.volume=7&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Orthography (or5); Aphasia (ap1); Language Pathology (la4) ER - TY - JOUR T1 - Determination of Valproic Acid by Flame-Ionization Gas-Liquid Chromatography AN - 1093462864; 17184413 AB - A rapid method is described for determination of valproic acid in biologic fluids by utilization of a gas chromatograph equipped with a flame-ionization detector. After caproic acid is added to the biologic specimen as an internal standard, the specimen is extracted with 10% ethyl acetate in hexane, followed by direct chromatographic analysis using an SP-1000 liquid-phase column. The procedure does not require solvent evaporation. Recovery of the drug is approximately 100%. Inter-assay coefficient of variation is less than 4%. JF - Journal of Analytical Toxicology AU - Peyton, Gaylon A AU - Harris, Steven C AU - Wallace, Jack E AD - Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 and Laboratory Service, Veterans Administration Medical Hospital, San Antonio, TX 78284 Y1 - 1979/05// PY - 1979 DA - May 1979 SP - 108 EP - 110 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 3 IS - 3 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Chromatography KW - Evaporation KW - Valproic acid KW - Ethyl acetate KW - Solvents KW - Drugs KW - n-Hexane KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093462864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Determination+of+Valproic+Acid+by+Flame-Ionization+Gas-Liquid+Chromatography&rft.au=Peyton%2C+Gaylon+A%3BHarris%2C+Steven+C%3BWallace%2C+Jack+E&rft.aulast=Peyton&rft.aufirst=Gaylon&rft.date=1979-05-01&rft.volume=3&rft.issue=3&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/1979/00000003/00000003/art00008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Evaporation; Chromatography; Valproic acid; Ethyl acetate; Solvents; Drugs; n-Hexane ER - TY - JOUR T1 - Spectral Noise and Vocal Roughness Relationships in Adults with Laryngeal Pathology AN - 85445844; 8201785 AB - Adult Ms (N = 20), presenting laryngeal pathology, each produced 5 vowels & 2 sentences for tape recording. Individual recordings were then rated for roughness on a five-point equal-appearing intervals scale. Judges were 11 graduate students. Each vowel production was also analyzed spectrographically. High positive, multiple r was obtained between vowel spectral noise measures (dB SPL) & median roughness ratings for the vowels & sentences. The findings, similar to those previously reported for Ss without pathology, suggest that the relationships shown are independent of laryngeal health. Vowel spectral noise measures appear to provide a useful quantitative index of vocal roughness in vowels & connected speech. 5 Tables. HA JF - Journal of Communication Disorders AU - Hanson, Wayne AU - Emanuel, Floyd W AD - Veterans Administration Hospital, Sepulveda CA 91343 Y1 - 1979/04// PY - 1979 DA - April 1979 SP - 113 EP - 124 VL - 12 IS - 2 SN - 0021-9924, 0021-9924 KW - vowel production KW - spectral noise, vocal roughness correlations KW - adult male laryngeal pathology subjects KW - Vowel (vo4) KW - Verbal Task (ve3) KW - Laryngology (la12) KW - Speech Testing (sp12) KW - Phonation Disorders (ph4) KW - Noise (no1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85445844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Spectral+Noise+and+Vocal+Roughness+Relationships+in+Adults+with+Laryngeal+Pathology&rft.au=Hanson%2C+Wayne%3BEmanuel%2C+Floyd+W&rft.aulast=Hanson&rft.aufirst=Wayne&rft.date=1979-04-01&rft.volume=12&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Laryngology (la12); Noise (no1); Verbal Task (ve3); Vowel (vo4); Phonation Disorders (ph4); Speech Testing (sp12) ER - TY - JOUR T1 - Judgments by Children and Adults Regarding Communication Skills of Esophageal Speakers AN - 85445494; 8201799 AB - The intelligibility & acceptability of esophageal speech were judged by a group of children (N = 25 third graders) & a group of adults (N = 21). Esophageal speakers (N = 8) demonstrating a range of speech proficiency & differing vocal characteristics were videotaped reading a children's story. The recordings were played to Ss who were asked to respond to multiple-choice questions concerning story content. Responses as to intelligibility, as determined by both test scores & subjective interpretation of acceptability, were analyzed. Within-group & between-group comparisons showed that children achieved higher intelligibility scores & employed different values than did adults when listening to esophageal speech. 2 Tables. HA JF - Journal of Communication Disorders AU - Salmon, Shirley J AU - Kushner, Heraldean AU - Knox, A W AD - Veterans Administration Medical Center, 4801 Linwood Blvd Kansas City MO 64128 Y1 - 1979/04// PY - 1979 DA - April 1979 SP - 95 EP - 101 VL - 12 IS - 2 SN - 0021-9924, 0021-9924 KW - esophageal speech intelligibility, adult speaker videotapes KW - story comprehension, intelligibility ratings KW - adult/child listeners KW - Esophageal Speech (es1a) KW - Articulation (ar3) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85445494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Judgments+by+Children+and+Adults+Regarding+Communication+Skills+of+Esophageal+Speakers&rft.au=Salmon%2C+Shirley+J%3BKushner%2C+Heraldean%3BKnox%2C+A+W&rft.aulast=Salmon&rft.aufirst=Shirley&rft.date=1979-04-01&rft.volume=12&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Articulation (ar3); Esophageal Speech (es1a) ER - TY - JOUR T1 - The Effect of Syntactic Encoding on Sentence Comprehension in Aphasia AN - 85441596; 8100119 AB - Asked was whether it would be easier for an aphasic patient, ie, an agrammatic, to understand an idea presented as a series of syntactically simple propositions rather than as a single, complex one. Ss were 22 aphasic patients, 12 of whom were Broca's aphasics & 5 each were Wernicke's & Conduction aphasics. Of the 2 subtests designed, the first consisted of 6 subject-embedded constructions which varied along the dimensions of grammatical encodedness & plausibility, yielding 4 versions of each theme, which in turn created 24 items each. A 4-picture response card corresponded to each theme. The second subtest consisted of 48 items grouped into 4 categories: (1) before-after, (2) compounds (compound subjects, compound Vs, & compound Os), (3) directionality, & (4) a composite category consisting of 2 sentences for each of 3 sentence types. Analysis results for subject-embedded sentences showed that expansion into two simple propositions did facilitate comprehension. This indicates that comprehension of syntactically complex sentences is not a simple function of the amount of information involved. It also suggests that a memory deficit alone cannot account for the difficulty aphasic patients have in dealing with complex linguistic material, since the expansion of embedded sentences also increases the length & presentation of the material. The failure to find a main effect or interaction due to real-world plausibility is not in agreement with some earlier findings. 3 Tables, 1 Figure. B. Annesser JF - Brain and Language AU - Goodglass, Harold AU - Blumstein, Sheila E AU - Gleason, Jean Berko AU - Hyde, Mary R AU - Green, Eugene AU - Statlender, Sheila AD - Boston Veterans Administration Hospital, MA 02130 Y1 - 1979/03// PY - 1979 DA - March 1979 SP - 201 EP - 209 VL - 7 IS - 2 SN - 0093-934X, 0093-934X KW - aphasia, sentence comprehension KW - syntactic encoding effect KW - Broca's/Wernicke's/Conduction aphasics KW - Neurolinguistics (ne3a) KW - Brain Anatomy (br1) KW - Cognitive Processes (co1b) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics KW - 4013: psycholinguistics; syntactic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Effect+of+Syntactic+Encoding+on+Sentence+Comprehension+in+Aphasia&rft.au=Goodglass%2C+Harold%3BBlumstein%2C+Sheila+E%3BGleason%2C+Jean+Berko%3BHyde%2C+Mary+R%3BGreen%2C+Eugene%3BStatlender%2C+Sheila&rft.aulast=Goodglass&rft.aufirst=Harold&rft.date=1979-03-01&rft.volume=7&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Aphasia (ap1); Cognitive Processes (co1b); Brain Anatomy (br1) ER - TY - JOUR T1 - Paralinguistic Aspects of Auditory Comprehension in Aphasia AN - 58068579; 8101469 AB - Eight aphasic patients with unilateral left hemisphere damage served as Ss, & were selected on the basis of having an observable comprehension disorder. The test battery consisted of 60 sentences; 10 were judged to be of "high emotional" content, 20 of "low emotional" content, & 30 neutral. All items were presented in a single mode: either the examiner read the sentences to the S, or the S listened to a tape of the sentences. Results showed that both content & mode of presentation played a significant role in aphasic Ss' responses. The 10 "high emotional" responses produced more feedback & a significantly greater number of correct responses than any other group, when the judging criteria (correct, appropriate, change in general behavior) were combined. A model of comprehension involving several stages (not necessarily successive) is discussed. It is suggested that aphasic impairment hampers a final step in the process, in which exact meaning is determined. Results suggest that an additonal factor, sentence content, influences aphasics' responses to auditory stimulus. 3 Tables, 2 Figures, Appendix. B. Annesser JF - Brain and Language AU - Boller, Francois AU - Cole, Monroe AU - Vrtunski, P Bart AU - Patterson, Marian AU - Kim, Youngjai AD - Cleveland Veterans Administration Hospital, OH 44106 Y1 - 1979/03// PY - 1979 DA - March 1979 SP - 164 EP - 174 VL - 7 IS - 2 SN - 0093-934X, 0093-934X KW - aphasia auditory comprehension KW - presentation content/mode KW - comprehension-disordered aphasic patients KW - Neurolinguistics (ne3a) KW - Cognitive Processes (co1b) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Paralinguistic+Aspects+of+Auditory+Comprehension+in+Aphasia&rft.au=Boller%2C+Francois%3BCole%2C+Monroe%3BVrtunski%2C+P+Bart%3BPatterson%2C+Marian%3BKim%2C+Youngjai&rft.aulast=Boller&rft.aufirst=Francois&rft.date=1979-03-01&rft.volume=7&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Neurolinguistics (ne3a); Cognitive Processes (co1b) ER - TY - JOUR T1 - Effects of Clinician Behaviors on Acceptability of Patients' Responses in Aphasia Treatment Sessions AN - 85450350; 8205212 AB - Records of the content of 40 videotaped samples of aphasia treatment sessions were prepared & analyzed to determine: (1) whether certain clinician behaviors & task characteristics are related to the occurrence of patient error responses in speech & language treatment sessions, & (2) whether "errors generate errors," ie, whether error responses tend to occur in clusters rather than being distributed uniformly throughout the session. Results, indicating that several event categories were significantly related to the occurrence of unacceptable patient responses, suggest that certain clinicians tend to respond to errors in characteristic ways. Unacceptable patient responses also tended to occur in clusters. 2 Tables. HA JF - Journal of Communication Disorders AU - Brookshire, R AU - Nicholas, L AU - Redmond, K AU - Krueger, K AD - Veterans Administration Medical Center, 54th St & 48th Ave Minneapolis MN 55417 Y1 - 1979///0, PY - 1979 DA - 0, 1979 SP - 369 EP - 384 VL - 12 IS - 5 SN - 0021-9924, 0021-9924 KW - aphasia patients KW - treatment responses KW - clinician behavior effects KW - Error Analysis (er1) KW - Language Therapy (la7a) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85450350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Effects+of+Clinician+Behaviors+on+Acceptability+of+Patients%27+Responses+in+Aphasia+Treatment+Sessions&rft.au=Brookshire%2C+R%3BNicholas%2C+L%3BRedmond%2C+K%3BKrueger%2C+K&rft.aulast=Brookshire&rft.aufirst=R&rft.date=1979-01-01&rft.volume=12&rft.issue=5&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Therapy (la7a); Error Analysis (er1) ER - TY - JOUR T1 - Lipid and carbohydrate metabolism in euthyroid and hypothyroid chick embryo (Gallus domesticus). AN - 75024151; 233792 AB - 1. The effect of propylthiouracil (PTU)-induced hypothyroidism on carbohydrate and lipid metabolism was studied in the chick embryo. 2. A single dose of PTU (250 micrograms/embryo) was administered on day 11 and embryos sacrificed on day 20 of incubation. 3. Thyroid glands were significantly enlarged (6 fold) by PTU administration. 4. Increased thyroid weight was associated with growth retardation and decreased plasma thyroxine levels. 5. Plasma glucose level was lower and phospholipids were significantly higher in the hypothyroid embryo. 6. Liver lipid concentrations in the control and hypothyroid embryos were not different but were significantly higher in both groups when compared to previously reported values in the young chick. 7. In contrast to PTU treatment after hatching, liver glycogen levels were not increased in the hypothyroid chick embryo. This was attributed to the high lipid nutrient condition of the chick embryo since a high lipid diet in the young chick decreased hepatic glycogen accumulation significantly. JF - Comparative biochemistry and physiology. B, Comparative biochemistry AU - Raheja, K L AU - Linscheer, W G AD - Department of Pharmacology, Veterans Administration Medical Center, Syracuse, NY. Y1 - 1979 PY - 1979 DA - 1979 SP - 289 EP - 291 VL - 64 IS - 3 SN - 0305-0491, 0305-0491 KW - Blood Glucose KW - 0 KW - Phospholipids KW - Triglycerides KW - Propylthiouracil KW - 721M9407IY KW - Cholesterol KW - 97C5T2UQ7J KW - Glucose-6-Phosphatase KW - EC 3.1.3.9 KW - Index Medicus KW - Triglycerides -- blood KW - Phospholipids -- blood KW - Cholesterol -- blood KW - Animals KW - Blood Glucose -- metabolism KW - Liver -- drug effects KW - Chick Embryo KW - Glucose-6-Phosphatase -- blood KW - Body Weight -- drug effects KW - Organ Size -- drug effects KW - Thyroid Gland -- physiology KW - Thyroid Gland -- drug effects KW - Hypothyroidism -- metabolism KW - Thyroid Gland -- growth & development KW - Hypothyroidism -- chemically induced KW - Lipid Metabolism KW - Carbohydrate Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75024151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+B%2C+Comparative+biochemistry&rft.atitle=Lipid+and+carbohydrate+metabolism+in+euthyroid+and+hypothyroid+chick+embryo+%28Gallus+domesticus%29.&rft.au=Raheja%2C+K+L%3BLinscheer%2C+W+G&rft.aulast=Raheja&rft.aufirst=K&rft.date=1979-01-01&rft.volume=64&rft.issue=3&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+B%2C+Comparative+biochemistry&rft.issn=03050491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-13 N1 - Date created - 1989-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - RPRT T1 - Reactions to Assertive Versus Unassertive Behavior: Differential Effects for Males and Females and Implications for Assertive Training. AN - 63607777; ED193424 AB - While a great deal of clinical research attention has been directed toward assertive training, there have been few studies examining the social impact or interpersonal evaluation of assertive versus unassertive behavior, including the differential evaluation of assertiveness exhibited by males and females. In this study, subjects observed a videotape showing a male or female stimulus model behaving either assertively or unassertively during four interactions similar to those used in assertive training research. Subjects then completed an interpersonal attraction inventory to evaluate the model they observed. Results indicated that while assertive models were viewed as skilled and able, they were given lower ratings on measures of likeability than unassertive models. Further, interaction effects indicated that assertive behavior exhibited by females resulted in more negative evaluations than the identical behavior in males. (LRA) AU - Kelly, Jeffrey A. Y1 - 1979 PY - 1979 DA - 1979 SP - 30 KW - ERIC, Resources in Education (RIE) KW - Comparative Analysis KW - Personality Traits KW - Individual Psychology KW - Males KW - Behavior Patterns KW - Social Behavior KW - Sex Differences KW - Females KW - Aggression KW - Assertiveness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63607777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ERIC&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Kelly%2C+Jeffrey+A.&rft.aulast=Kelly&rft.aufirst=Jeffrey&rft.date=1979-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Reactions+to+Assertive+Versus+Unassertive+Behavior%3A+Differential+Effects+for+Males+and+Females+and+Implications+for+Assertive+Training.&rft.title=Reactions+to+Assertive+Versus+Unassertive+Behavior%3A+Differential+Effects+for+Males+and+Females+and+Implications+for+Assertive+Training.&rft.issn=&rft_id=info:doi/ LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Cooperative Behavior: A Neurosocial Hypothesis AN - 61088841; 82M5733 AB - Cooperative behavior in group living has been explained as the result of a genetic mechanism for altruism. It is suggested instead that a neural mechanism that has evolved to facilitate learning also produces cooperative behavior. During human evolution, the emotional states associated with defense, competition, & hunting could reinforce successful cooperative behavior through the influence of the limbic system. These affective states could serve to facilitate & reinforce cooperative behavior through the consolidation of successful sensory & motor patterns. Moreover, during the socialization process, social norms, values, & beliefs stored in the memory have an affective investment as a result of limbic function. This affective component can provide motivation for accepted behavior in any given group. The limbic mechanism provides both stability & flexibility: it provides stability by ensuring adherence to patterns of behavior that have proven successful in the past, & flexibility by influencing the storage of new &/or different norms of the memory. AA. JF - Man-Environment Systems AU - Sengel, Randal A AD - Veterans Administration Medical Center, 921 Northeast 13th St Oklahoma City OK 73104 Y1 - 1979/01// PY - 1979 DA - January 1979 SP - 48 EP - 54 VL - 9 IS - 1 SN - 0025-1550, 0025-1550 KW - cooperative behavior, group living, neurosocial hypothesis KW - Behavior/Behavioral KW - Cooperative/Cooperatives KW - Neurology/Neurological KW - Group/Groups/Grouping/Groupism KW - Social KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61088841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Man-Environment+Systems&rft.atitle=Cooperative+Behavior%3A+A+Neurosocial+Hypothesis&rft.au=Sengel%2C+Randal+A&rft.aulast=Sengel&rft.aufirst=Randal&rft.date=1979-01-01&rft.volume=9&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Man-Environment+Systems&rft.issn=00251550&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - MESYDL N1 - SubjectsTermNotLitGenreText - Cooperative/Cooperatives; Behavior/Behavioral; Group/Groups/Grouping/Groupism; Neurology/Neurological; Social ER - TY - JOUR T1 - Espousing Melodic Intonation Therapy in Aphasia Rehabilitation: A Case Study AN - 58075786; 8205219 AB - A program of melodic intonation therapy (MIT) was adapted for use at home to enable the severely affected aphasic adult to respond to simple questions relevant to daily life. The program involves embedding short phrases or sentences in simple, nondistinct melody patterns. The melody is gradually faded out during therapy until the phrases can be produced in normal speech prosody. Use of the training program with 1 S is described. 3 Tables, 4 Figures. Modified HA JF - International Journal of Rehabilitation Research/Internationale Zeitschrift fur Rehabilitationsforschung/Revue Internationale de Recherches de Readaptation AU - Goldfarb, Robert AU - Bader, Ellen AD - Veterans Administration Extended Care Center, Saint Albans NY 11425 Y1 - 1979///0, PY - 1979 DA - 0, 1979 SP - 333 EP - 342 VL - 2 IS - 3 SN - 0342-5282, 0342-5282 KW - aphasics' rehabilitation, melodic intonation therapy KW - case study KW - Intonation (in17) KW - Speech Therapy (sp13) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58075786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rehabilitation+Research%2FInternationale+Zeitschrift+fur+Rehabilitationsforschung%2FRevue+Internationale+de+Recherches+de+Readaptation&rft.atitle=Espousing+Melodic+Intonation+Therapy+in+Aphasia+Rehabilitation%3A+A+Case+Study&rft.au=Goldfarb%2C+Robert%3BBader%2C+Ellen&rft.aulast=Goldfarb&rft.aufirst=Robert&rft.date=1979-01-01&rft.volume=2&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rehabilitation+Research%2FInternationale+Zeitschrift+fur+Rehabilitationsforschung%2FRevue+Internationale+de+Recherches+de+Readaptation&rft.issn=03425282&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - IJRRDK N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Speech Therapy (sp13); Intonation (in17) ER - TY - JOUR T1 - Aerodynamic Interactions Associated with Voiced-Voiceless Stop Consonants AN - 58071090; 8104637 AB - Investigated was the role of the respiratory driving pressure for voiced-voiceless cognate pairs in cons-vowel (CV) & vowel-cons-vowel (VCV) syllables. American English normal speakers (N = 3 Ms, 1 F aged 19 to 31) produced 10 CV & VCV utterances in isolation & 6 VCV in phrase; simultaneous measures of subglottic & supraglottic air pressure were obtained. The respiratory system generated an essentially nonvariant force; voicing contrast was regulated at or above the larynx. 1 Table, 2 Figures. Modified HA JF - Folia Phoniatrica AU - Murry, Thomas AU - Brown, William S, Jr AD - Veterans Administration Hospital, San Diego CA 92161 Y1 - 1979///0, PY - 1979 DA - 0, 1979 SP - 82 EP - 88 VL - 31 IS - 1 SN - 1021-7762, 1021-7762 KW - voiced vs voiceless stop consonants production KW - respiratory driving pressure KW - Cognate (co1) KW - Air Flow (ai3) KW - Consonant (co14) KW - Phonation Structures (ph5) KW - English (en2) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58071090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Folia+Phoniatrica&rft.atitle=Aerodynamic+Interactions+Associated+with+Voiced-Voiceless+Stop+Consonants&rft.au=Murry%2C+Thomas%3BBrown%2C+William+S%2C+Jr&rft.aulast=Murry&rft.aufirst=Thomas&rft.date=1979-01-01&rft.volume=31&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Folia+Phoniatrica&rft.issn=10217762&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - FOPHAD N1 - SubjectsTermNotLitGenreText - Consonant (co14); English (en2); Air Flow (ai3); Cognate (co1); Phonation Structures (ph5) ER - TY - JOUR T1 - Aphasia Following Infarction of the Left Supplementary Motor Area AN - 85441946; 7904619 AB - Speech disturbance in a seventy-six-year-old F with a single embolic infarct of the left supplementary motor area was observed. It was characterized by initial mutism, rapid recovery to fluent speech marked by short sentences with normal grammar, persistent severe impairment of writing, & frustration & anxiety related to language tasks. It is confirmed that a speech disturbance results from an infarction in the anterior cerebral artery area, not just the perisylvian speech area. 2 Figures. Modified HA JF - Neurology AU - Masdeu, J C AU - Schoene, W C AU - Funkenstein, H AD - Hines Veterans Administration Hospital, IL 60141 Y1 - 1978/12// PY - 1978 DA - December 1978 SP - 1220 EP - 1223 VL - 28 IS - 12 SN - 0028-3878, 0028-3878 KW - aphasia, left supplementary motor area infarction KW - 76-year-old female KW - case study KW - Brain Anatomy (br1) KW - Language Planning (la4a) KW - Nervous System Pathology (ne3) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Aphasia+Following+Infarction+of+the+Left+Supplementary+Motor+Area&rft.au=Masdeu%2C+J+C%3BSchoene%2C+W+C%3BFunkenstein%2C+H&rft.aulast=Masdeu&rft.aufirst=J&rft.date=1978-12-01&rft.volume=28&rft.issue=12&rft.spage=1220&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Planning (la4a); Nervous System Pathology (ne3); Brain Anatomy (br1) ER - TY - JOUR T1 - Pinpointing the Cause of Disturbed Behavior in the Elderly AN - 61559289; 198100580 AB - Psychiatric symptoms are common in elderly people, but psychiatric help is not always necessary. Many such symptoms have a simple explanation. Performance anxiety may play a major role in memory deficits. Inappropriate decisions & judgments may be the result of defective hearing & visual acuity. Inability to adjust to stress & environmental change may explain bizarre behavior, & self-imposed loneliness may be a defense against being hurt. Depression is a frequent concomitant of aging, but differential diagnosis is not easy. Depressed patients often have symptoms of organic impairment, & organic impairment is often accompanied by depression. Paranoid ideation is frequently present but may be mislabeled "schizophrenia." Treatment of behavioral disturbances demands time, imagination, & patience. The MD must take a thorough history, touching on all aspects of the patient's life. Milieu therapy may solve the problem, or the disturbance may require careful administration of a tranquilizer, an antidepressant, or electroconvulsive therapy. Treatment goals are usually limited, but can be meaningful & rewarding to both MD & patient. AA. JF - Geriatrics AU - Gfeller, Eduard AD - Veterans Administration Hospital, Gainesville FL 32602 Y1 - 1978/12// PY - 1978 DA - December 1978 SP - 26 EP - 30 VL - 33 IS - 12 KW - elderly, psychiatric symptoms KW - psychiatric help, simple explanations, defective hearing, memory KW - Psychiatry/Psychiatric KW - Elder/Elders/Elderly KW - Mental health KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61559289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geriatrics&rft.atitle=Pinpointing+the+Cause+of+Disturbed+Behavior+in+the+Elderly&rft.au=Gfeller%2C+Eduard&rft.aulast=Gfeller&rft.aufirst=Eduard&rft.date=1978-12-01&rft.volume=33&rft.issue=12&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Geriatrics&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Mental health; Psychiatry/Psychiatric ER - TY - JOUR T1 - Letter Recognition Ability of Aphasic Subjects AN - 58100792; 8201968 AB - A study was designed to examine the letter-recognition abilities of 44 aphasic & 10 normal adult Ss. Normal Ss made no errors on the 26-item task. Moderately aphasic Ss (as determined by scores on the Porch Index of Communicative Ability) showed minimal difficulty but did not differ significantly in performance from normals. Severely aphasic Ss showed marked impairment & made significantly lower scores than the other group. Type of aphasia as determined by speech fluency seemed to affect letter recognition performance for the severely aphasic Ss. Fluent Ss in this group made significantly lower scores than all groups. The types of errors produced by the 2 severely aphasic groups offer some explanation as to their performance differences. Errors of the nonfluent group tended to involve letters related to the target letter, while errors of fluent aphasics tended to be random. This suggests that the nonfluent individual has a partially intact semantic associational network used in letter-recognition. 1 Table, 2 Figures. Modified HA JF - Perceptual and Motor Skills AU - Marshall, Robert C AU - Kushner, Deanie AU - Phillips, David AD - Veterans Administration Hospital, 3710 SW US Veterans Hospital Rd Portland OR 97201 Y1 - 1978/12// PY - 1978 DA - December 1978 SP - 1231 EP - 1238 VL - 47 IS - 3 SN - 0031-5125, 0031-5125 KW - letter recognition, aphasics, Porch Index of Communicative Ability KW - moderate/severe aphasics, normals KW - Letter Recognition and Discrimination (le2) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58100792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+Motor+Skills&rft.atitle=Letter+Recognition+Ability+of+Aphasic+Subjects&rft.au=Marshall%2C+Robert+C%3BKushner%2C+Deanie%3BPhillips%2C+David&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1978-12-01&rft.volume=47&rft.issue=3&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+Motor+Skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PMOSAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Letter Recognition and Discrimination (le2); Language Pathology (la4) ER - TY - JOUR T1 - Dichhaptic Hand-Order Effects with Verbal and Nonverbal Tactile Stimulation AN - 58095079; 8004795 AB - The palms of 15 normal right-handed Ss were stimulated dichhaptically, ie, with competing, bimanually presented tactile stimuli consisting of pairs of letters, pairs of digits, or pairs of line orientations. Ss were required to identify both stimuli in a particular order, & order of report was compared between hands & across stimulus materials. Results indicated right-hand superiority for identification of letters & left-hand superiority for identification of lines; no hand differences occurred for digits. However, observed differences between hands appeared with second reports only, suggesting that measures of tactile storage are more sensitive to cerebral laterality differences than measures closer in time to the actual stimulation. 2 Tables, 2 Figures. AA JF - Brain and Language AU - Oscar-Berman, Marlene AU - Rehbein, Lucio AU - Porfert, Alan AU - Goodglass, Harold AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 323 EP - 333 VL - 6 IS - 3 SN - 0093-934X, 0093-934X KW - tactile, verbal/nonverbal stimuli identification KW - right vs left hand KW - normal right-handed persons KW - Neurolinguistics (ne3a) KW - Handedness (ha2) KW - Memory (me3) KW - Cerebral Dominance (ce2) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58095079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Dichhaptic+Hand-Order+Effects+with+Verbal+and+Nonverbal+Tactile+Stimulation&rft.au=Oscar-Berman%2C+Marlene%3BRehbein%2C+Lucio%3BPorfert%2C+Alan%3BGoodglass%2C+Harold&rft.aulast=Oscar-Berman&rft.aufirst=Marlene&rft.date=1978-11-01&rft.volume=6&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Cerebral Dominance (ce2); Handedness (ha2); Memory (me3) ER - TY - JOUR T1 - The Appreciation of Antonymic Contrasts in Aphasia AN - 58080195; 8004791 AB - To secure information on the ability of aphasic patients to comprehend antonymic relations, the kinds of confusions typically made, & the extent to which antonymic sensitivity depends upon mode of presentation & task demands, three linguistic & nonlinguistic tests were administered to aphasic patients, right-hemisphere damaged patients, & nonneurological controls. Although difficulty with antonymous relations was found among all the organic patients, the kinds of problems evidenced & the relative profile of difficulties differed across populations. Among the principal findings were the generally-preserved sensitivity to antonymy found among anterior (particularly Broca's) aphasics; a surprising insensitivity to antonymy, & a preference for synonyms, found among right-hemisphere patients, particularly on the nonlinguistic tasks; a relative preservation of sensitivity to antonymy on nonlinguistic tasks, coupled with a loss of such sensitivity on linguistic tasks, found among posterior (particularly Wernicke's) aphasics; a proclivity toward stereotypical correct responses among the organic patients; & an absolutely worse performance by right-hemisphere patients on tasks involving antonymic relations in pictures & abstract designs. 3 Tables, 4 Figures. AA JF - Brain and Language AU - Gardner, Howard AU - Silverman, Jen AU - Wapner, Wendy AU - Zurif, Edgar B AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 301 EP - 317 VL - 6 IS - 3 SN - 0093-934X, 0093-934X KW - antonyms comprehension KW - linguistic vs nonlinguistic tasks KW - aphasic, right-hemisphere-damaged patients, controls KW - Neurolinguistics (ne3a) KW - Antonym (an5) KW - Language Pathology (la4) KW - Nervous System Pathology (ne3) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58080195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Appreciation+of+Antonymic+Contrasts+in+Aphasia&rft.au=Gardner%2C+Howard%3BSilverman%2C+Jen%3BWapner%2C+Wendy%3BZurif%2C+Edgar+B&rft.aulast=Gardner&rft.aufirst=Howard&rft.date=1978-11-01&rft.volume=6&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Antonym (an5); Nervous System Pathology (ne3); Language Pathology (la4); Neurolinguistics (ne3a) ER - TY - JOUR T1 - Aphasia Type and Aging AN - 58078648; 8004793 AB - Records of 198 patients with language disturbances were reviewed, & 167 selected for study. All were right-handed Ms who had suffered acute cerebrovascular accidents & had been diagnosed as having some specific form of aphasia. Median ages were calculated for each aphasic group (Broca's, Wernicke's, Anomic, Conduction, & Global) & the number of Ss with each aphasia type in each decade (30-39, etc) was determined. Two main results were produced. First, Wernicke's aphasics were significantly older than any other group, whereas Broca's aphasics were considerably younger. Second, the incidence of Wernicke's aphasia appears to increase steadily with age, while the other types show a steady increase to a peak (around ages 52 to 57) & then a steady decline afterwards. Several possible explanations for the findings are offered, although sufficient data are lacking to confirm any one of them at present. 2 Tables, 1 Figure. B. Annesser JF - Brain and Language AU - Obler, Loraine K AU - Albert, Martin L AU - Goodglass, Harold AU - Benson, D Frank AD - Veterans Administration Hospital, 150 South Huntington Ave Boston MA 02130 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 318 EP - 322 VL - 6 IS - 3 SN - 0093-934X, 0093-934X KW - aphasia type, incidence KW - age KW - aphasic right-handed males KW - Neurolinguistics (ne3a) KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - Age Differences in Language (ag1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58078648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Aphasia+Type+and+Aging&rft.au=Obler%2C+Loraine+K%3BAlbert%2C+Martin+L%3BGoodglass%2C+Harold%3BBenson%2C+D+Frank&rft.aulast=Obler&rft.aufirst=Loraine&rft.date=1978-11-01&rft.volume=6&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Age Differences in Language (ag1); Language Pathology (la4); Neurolinguistics (ne3a); Nervous System Pathology (ne3) ER - TY - JOUR T1 - An Extraordinary Form of Confabulation AN - 58071707; 7904634 AB - Five brain-damaged patients are described with spontaneous, persistent confabulation - the production of erroneous & made-up verbal material. While the basis of confabulation is not generally known, evidence in this specific group with spectacular, impulsive, & spontaneous confabulation suggests a marked deficit in frontal function, superimposed upon a basic defect in memory as a possible mechanism. 1 Table, 2 Figures. Modified HA JF - Neurology AU - Stuss, Donald T AU - Alexander, Michael P AU - Lieberman, Aubrey AU - Levine, Harvey AD - Boston Veterans Administration Hospital, 150 S Huntington Ave MA 02130 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 1166 EP - 1172 VL - 28 IS - 11 SN - 0028-3878, 0028-3878 KW - spectacular, spontaneous confabulation KW - brain-damaged patients KW - case studies KW - Memory (me3) KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58071707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=An+Extraordinary+Form+of+Confabulation&rft.au=Stuss%2C+Donald+T%3BAlexander%2C+Michael+P%3BLieberman%2C+Aubrey%3BLevine%2C+Harvey&rft.aulast=Stuss&rft.aufirst=Donald&rft.date=1978-11-01&rft.volume=28&rft.issue=11&rft.spage=1166&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Nervous System Pathology (ne3); Memory (me3) ER - TY - JOUR T1 - Acquired Stuttering AN - 58070182; 7904614 AB - Acquired stuttering secondary to brain damage in adults has received little attention relative to that given developmental stuttering. Examined were the speech characteristics, neuropsychologic deficits, & neuroanatomic correlates of 10 patients with acquired stuttering. The speech characteristics which differentiate acquired stuttering include: absence of adaptation effect, occurrence of stuttering on any syllable within a word, & stuttering on both grammatical & substantive words. The neurobehavioral deficits correlated with acquired stuttering include: impaired ability to draw or copy three-dimensional figures or to reproduce block designs, & difficulty in reproducing & sustaining sequential motor tasks, melodies, & rhythmic tapping patterns. Two varieties of this disorder were identified. While patients affected with both varieties have evidence of multifocal hemispheric damage, transient acquired stuttering was associated with unilateral (left) foci, & persistent acquired stuttering with bilateral pathology. 1 Table. Modified HA JF - Neurology AU - Helm, Nancy A AU - Butler, Russell B AU - Benson, D Frank AD - Aphasia Research Section Boston Veterans Administration Hospital, 150 S Huntington Ave MA 02130 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 1159 EP - 1165 VL - 28 IS - 11 SN - 0028-3878, 0028-3878 KW - transient vs persistent acquired stuttering, speech characteristics, neurobehavioral deficits KW - Neurolinguistics (ne3a) KW - Stuttering (st9) KW - Cerebral Dominance (ce2) KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58070182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Acquired+Stuttering&rft.au=Helm%2C+Nancy+A%3BButler%2C+Russell+B%3BBenson%2C+D+Frank&rft.aulast=Helm&rft.aufirst=Nancy&rft.date=1978-11-01&rft.volume=28&rft.issue=11&rft.spage=1159&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Stuttering (st9); Nervous System Pathology (ne3); Neurolinguistics (ne3a); Cerebral Dominance (ce2) ER - TY - JOUR T1 - The Clinical Interaction Analysis System: A System for Observational Recording of Aphasia Treatment AN - 58069426; 8001435 AB - The Clinical Interaction Analysis System (CIAS) is described. CIAS is designed to record events that occur in treatment sessions for aphasic individuals, & to provide an objective comparison of various treatment methods. Development of CIAS is summarized, event categories contained in CIAS are described, & uses of the system are discussed. CIAS is useful in situations where clinicians are trained to conduct treatment programs for aphasics. CIAS could also be useful in exploring the relationship between a particular type of treatment, & the recovery experienced by patients undergoing that treatment. Information about the reliability of CIAS is also presented. Appendix. Modified HA JF - Journal of Speech and Hearing Disorders AU - Brookshire, Robert H AU - Nicholas, Linda S AU - Krueger, Kathleen M AU - Redmond, Kathleen J AD - Veterans Administration Hospital, Minneapolis MN 55417 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 437 EP - 447 VL - 43 IS - 4 KW - aphasia treatment, observational recording system KW - Language Therapy (la7a) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58069426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=The+Clinical+Interaction+Analysis+System%3A+A+System+for+Observational+Recording+of+Aphasia+Treatment&rft.au=Brookshire%2C+Robert+H%3BNicholas%2C+Linda+S%3BKrueger%2C+Kathleen+M%3BRedmond%2C+Kathleen+J&rft.aulast=Brookshire&rft.aufirst=Robert&rft.date=1978-11-01&rft.volume=43&rft.issue=4&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Therapy (la7a); Aphasia (ap1) ER - TY - JOUR T1 - Some Observations in a Case of Acoustic Neuroma AN - 58069202; 8001405 AB - A 47-year-old M with moderate asymmetrical sensorineural hearing loss that initially presented cochlear signs, except for positive stapedius reflex results, served as S. Over the course of only 5 weeks, he developed the audiological constellation of retrocochlear involvement. Retrocochlear results were confirmed by the removal of an acoustic tumor. Results highlight the importance of audiological monitoring & reflex measures in the identification of acoustic neuromas. Several observations provide insight into the apparent relationship between loudness & the stapedius reflex. Findings are discussed with reference to a proposed extension of Borg's recent theory that elevated reflex thresholds & reflex decay reflect differing degrees of the eighth nerve destruction. 2 Tables, 2 Figures. Modified HA JF - Journal of Speech and Hearing Disorders AU - Silman, Shlomo AU - Gelfand, Stanley A AU - Chun, Tong AD - Veterans Administration Hospital, East Orange NJ 07019 Y1 - 1978/11// PY - 1978 DA - November 1978 SP - 459 EP - 466 VL - 43 IS - 4 KW - acoustic neuroma determination KW - case study KW - Hearing Disorders (he3a) KW - Audiology (au2) KW - Inner Ear (in6) KW - Intensity of Vibration (in12) KW - Perception (pe3) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58069202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Some+Observations+in+a+Case+of+Acoustic+Neuroma&rft.au=Silman%2C+Shlomo%3BGelfand%2C+Stanley+A%3BChun%2C+Tong&rft.aulast=Silman&rft.aufirst=Shlomo&rft.date=1978-11-01&rft.volume=43&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Audiology (au2); Perception (pe3); Hearing Disorders (he3a); Inner Ear (in6); Intensity of Vibration (in12) ER - TY - JOUR T1 - Parastandardized Examination Guidelines for Adult Aphasia AN - 58073366; 7906001 AB - A twenty-point examination guide is offered as a model for speech pathologists to broaden their knowledge of aphasic patients' behavior beyond the limits afforded by the standardized & published aphasia tests. Although the guide's major purpose is to focus on the patient as a potential candidate for language therapy, it also discusses the examination strategies used by the clinician to facilitate the aphasic's maximum lang recovery. The guide outlines twenty aspects of language & nonverbal behavior of maximum concern to the clinician. It is limited to examination of auditory comprehension & verbal expression, felt to be most important in linguistic rehabilitation. The guide is used as a basis for describing three major aphasia types. Modified HA JF - The British Journal of Disorders of Communication AU - Sparks, Robert W AD - Veterans Administration Hospital, Boston MA Y1 - 1978/10// PY - 1978 DA - October 1978 SP - 135 EP - 146 VL - 13 IS - 2 SN - 0007-098X, 0007-098X KW - parastandard adult aphasia examination guidelines KW - Language Therapy (la7a) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58073366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Disorders+of+Communication&rft.atitle=Parastandardized+Examination+Guidelines+for+Adult+Aphasia&rft.au=Sparks%2C+Robert+W&rft.aulast=Sparks&rft.aufirst=Robert&rft.date=1978-10-01&rft.volume=13&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Disorders+of+Communication&rft.issn=0007098X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJDCBU N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Language Therapy (la7a) ER - TY - JOUR T1 - Potassium cardioplegia: early assessment by radionuclide ventriculography. AN - 83813976; 14740679 AB - Left ventricular function was evaluated by single pass Tc-99m radionuclide ventriculography when potassium cardioplegia was combined with hypothermia. In 35 patients undergoing myocardial revascularization (3 CABG/patient) in which potassium cardioplegia at 4 degrees C was used, no patient developed a myocardial infarction either by electrocardiogram or Tc-99m pyrophosphate imaging in the postoperative period. In 22 patients, aortic cross-clamp time was greater than 60 min, and the ejection fraction by the single pass radionuclide technique was 50% preoperatively and 53% postoperatively (NS). Wall motion in the single RAO view was not worse postoperatively. No patient required any inotropic agents in the immediate postoperative period. It appears that no significant ventricular impairment occurred in the immediate postoperative period (48 to 72 hours) when potassium cardioplegia combined with hypothermia was used for a 60-minute period. JF - Circulation AU - Ellis, R J AU - Born, M AU - Feit, T AU - Ebert, P A AD - Department of Surgery, Veterans Administration Hospital, San Francisco, California 94121, USA. Y1 - 1978/09// PY - 1978 DA - September 1978 SP - I57 EP - I61 VL - 58 IS - 3 Pt 2 SN - 0009-7322, 0009-7322 KW - Cardioplegic Solutions KW - 0 KW - Potassium KW - RWP5GA015D KW - Abridged Index Medicus KW - Index Medicus KW - Heart Failure -- etiology KW - Cardioplegic Solutions -- adverse effects KW - Ventricular Function, Left KW - Heart Failure -- surgery KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Angina Pectoris -- complications KW - Monitoring, Intraoperative -- methods KW - Radionuclide Imaging -- methods KW - Male KW - Heart Function Tests KW - Heart Arrest, Induced -- methods KW - Radionuclide Ventriculography -- methods KW - Coronary Artery Bypass KW - Potassium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/83813976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Potassium+cardioplegia%3A+early+assessment+by+radionuclide+ventriculography.&rft.au=Ellis%2C+R+J%3BBorn%2C+M%3BFeit%2C+T%3BEbert%2C+P+A&rft.aulast=Ellis&rft.aufirst=R&rft.date=1978-09-01&rft.volume=58&rft.issue=3+Pt+2&rft.spage=I57&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-11 N1 - Date created - 2004-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - The Necessity and Desirability of Including Recipients of Federal Grants Other Than from the Veterans Administration in the 85-15 Ratio Computation. (Prepared in Compliance With Section 305, Public Law 95-202). House Committee Print No. 168. AN - 63754649; ED168411 AB - This report presents the findings and recommendations of a study by the Veterans Administration concerning the necessity for including in the computation of the 85-15 ratio those students in receipt of grants from federal agencies other than the Veterans Administration. The problems incurred by educational institutions in the implementation of the provisions of the law (section 1673(d), title 38, United States Code) are also examined. The study was conducted from May 15, 1978, through July 24, 1978, by staff members of the Veterans Administration. Officials of 16 schools in California, Georgia, Illinois, New York, and Texas were interviewed. The officials were asked to describe in detail their school's administrative organizations, registration procedures, policies for declarations of majors by students, and the information systems that are used by their schools. This report includes background information on the 85-15 ratio rule, the Basic Educational Opportunity Grant Program (BEOG), and the Supplemental Educational Opportunity Grant Program (SEOG). Based on the findings and conclusions of the study, it is recommended that the law be amended to rescind the requirement that recipients of BEOG and/or SEOG benefits shall be considered in computing 85-15 ratios. Appendices included the revised DVB circular 20-76-84; the interview schedule; and student, veteran, BEOG, and SEOG enrollment data for the educational institutions visited during the study. (SW) Y1 - 1978/09// PY - 1978 DA - September 1978 SP - 23 PB - Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 KW - Basic Educational Opportunity Grants KW - California KW - Georgia KW - Illinois KW - New York KW - Supplemental Educational Opportunity Grants KW - Texas KW - Veterans Administration KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - Institutional Characteristics KW - Federal Aid KW - Grants KW - Higher Education KW - College Administration KW - Eligibility KW - Student Financial Aid KW - Computation KW - Federal Legislation KW - Federal Regulation KW - Program Evaluation KW - Financial Aid Applicants KW - Veterans Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63754649?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - SuppNotes - Tables are in small print N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Speaking Fundamental Frequency Characteristics Associated with Voice Pathologies AN - 85435830; 8001420 AB - The relationship between pathologic & normal-speaking fundamental f characteristics (SFF) in a group of 80 M Ss was investigated. Ss were divided into 4 groups of 20 each: (1) vocal fold paralysis, (2) benign mass lesion, (3) cancer of the larynx, & (4) normal. Results indicate that SFF standard deviation & semitone range of SFF are significantly reduced for patients with vocal fold paralysis as compared with normals. The parameters of mean SFF, number of f shifts, & age failed to separate the normals from the three groups of pathologic Ss. The similarity of SFF for the three groups suggests that factors other than SFF contribute to the acoustic identification of voice disorders. 3 Tables, 1 Figure. Modified HA JF - Journal of Speech and Hearing Disorders AU - Murry, Thomas AD - Veterans Administration Hospital, San Diego CA 92161 Y1 - 1978/08// PY - 1978 DA - August 1978 SP - 374 EP - 379 VL - 43 IS - 3 KW - speaking fundamental frequency KW - voice disorder type KW - pathological vs normal voiced males KW - Laryngology (la12) KW - Language Pathology (la4) KW - Phonation Disorders (ph4) KW - Fundamental Frequency (fu2) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85435830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Speaking+Fundamental+Frequency+Characteristics+Associated+with+Voice+Pathologies&rft.au=Murry%2C+Thomas&rft.aulast=Murry&rft.aufirst=Thomas&rft.date=1978-08-01&rft.volume=43&rft.issue=3&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Fundamental Frequency (fu2); Language Pathology (la4); Phonation Disorders (ph4); Laryngology (la12) ER - TY - JOUR T1 - Suicide Risk in the Medical Rehabilitation Setting AN - 61526803; 198101103 AB - Review of 150 requests for psychiatric consultation in a physical rehabilitation hospital during 1 year shows that 22 of these were related to concerns about suicide risk, deriving from the psychosocial stresses of physical disability. Specific characteristics of the suicidal situation that may arise in the course of the rehabilitation program are delineated, leading to presentation of a comprehensive framework for evaluation of present or potential suicide risk & to enumeration of specific treatment approaches & tasks in the management of the suicidal situation. Illustrative cases are presented. Management problems are identified for transient first-time episodes, for chronic or recurrent episodes, & for terminally ill patients. Modified HA. JF - Archives of Physical Medicine and Rehabilitation AU - Missel, Jerome L AD - Veterans Administration Hospital, Brockton MA 02401 Y1 - 1978/08// PY - 1978 DA - August 1978 SP - 371 EP - 376 VL - 59 IS - 8 KW - physical disability/suicide risk correlation KW - evaluation framework, treatment approaches, management problems KW - medical rehabilitation setting KW - Risk/Risks KW - Stress/Stresses KW - Disable/Disabled/Disability/ Disabilities KW - Suicide/Suicides/Suicidal KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61526803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Suicide+Risk+in+the+Medical+Rehabilitation+Setting&rft.au=Missel%2C+Jerome+L&rft.aulast=Missel&rft.aufirst=Jerome&rft.date=1978-08-01&rft.volume=59&rft.issue=8&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Disable/Disabled/Disability/ Disabilities; Stress/Stresses; Suicide/Suicides/Suicidal; Risk/Risks ER - TY - JOUR T1 - Disulfiram hepatitis. AN - 74448299; 401083 AB - A case of an adult with disulfiram-induced hepatitis is presented. An etiological role for the drug was proved when the patient underwent a provocative challenge and developed evidence of hepatocellular damage, reversible on withdrawal of the drug. Disulfiram-induced liver injury is difficult to detect in a population with a high incidence of alcohol-related hepatic disease. Liver chemistries should be screened before beginning disulfiram therapy and periodically during treatment. JF - Gastroenterology AU - Morris, S J AU - Kanner, R AU - Chiprut, R O AU - Schiff, E R AD - Department of Medicine, Veterans Administration Hospital, Miami, Florida 33125. Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 100 EP - 102 VL - 75 IS - 1 SN - 0016-5085, 0016-5085 KW - Disulfiram KW - TR3MLJ1UAI KW - Abridged Index Medicus KW - Index Medicus KW - Liver -- pathology KW - Humans KW - Middle Aged KW - Male KW - Alcoholism -- drug therapy KW - Chemical and Drug Induced Liver Injury -- etiology KW - Disulfiram -- therapeutic use KW - Disulfiram -- adverse effects KW - Chemical and Drug Induced Liver Injury -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74448299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Disulfiram+hepatitis.&rft.au=Morris%2C+S+J%3BKanner%2C+R%3BChiprut%2C+R+O%3BSchiff%2C+E+R&rft.aulast=Morris&rft.aufirst=S&rft.date=1978-07-01&rft.volume=75&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-23 N1 - Date created - 1990-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Effectiveness of Planning for Community Mental Health Center Inpatient Units AN - 61531068; 198200640 AB - An evaluation of the planning for community mental health center inpatient units is presented, focusing on the inpatient capacity of each of 308 federally funded centers in operation since 1972 & how this related to other aspects of inpatient operation. Precoded indices of community mental health center program operation were derived from the 1972 Inventory of Federally Funded Community Mental Health Centers (no further publication information provided). The number of beds identified among the centers bore little relation to inpatient case load or to the proportion of center patients likely to require hospitalization. Analysis of occupancy data indicated that there was a surplus of beds in many centers. These findings suggest a lack of effective planning for community mental health center inpatient units. Once facilities for hospitalization have been provided, however, they may have a major impact on the nature of psychiatric treatment. This is suggested by the close relationship between inpatient capacity & average duration of stay. 3 Tables, 1 Figure. Modified HA. JF - Community Mental Health Journal AU - Goldman, Ronald L AU - Keller, Timothy W AD - Veterans Administration Hospital, Battle Creek MI 49016 Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 100 EP - 109 VL - 14 IS - 2 SN - 0010-3853, 0010-3853 KW - community mental health center inpatient units, planning evaluation KW - capacity, average duration of stay KW - Patient/Patients KW - Community/Communities/Communitarian KW - Center/Centers KW - Mental health KW - Unit/Units KW - Plan/Plans/Planning/Planned/ Planners KW - article KW - 7220: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61531068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=The+Effectiveness+of+Planning+for+Community+Mental+Health+Center+Inpatient+Units&rft.au=Goldman%2C+Ronald+L%3BKeller%2C+Timothy+W&rft.aulast=Goldman&rft.aufirst=Ronald&rft.date=1978-07-01&rft.volume=14&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Community/Communities/Communitarian; Mental health; Center/Centers; Patient/Patients; Unit/Units; Plan/Plans/Planning/Planned/ Planners ER - TY - JOUR T1 - Working with Families within Inpatient Settings AN - 61465191; 198100156 AB - The family's experience of psychiatric hospitalization is examined. Considered are ways in which the family therapist can help keep the family system intact & involve it in the inpatient treatment process. Family-related & hospital-related obstacles to family involvement are discussed, along with suggestions for dealing with them. Family problems characteristic of an adult hospitalization population & suggested treatment strategies are presented. HA. JF - Journal of Marriage and Family Counseling AU - Biddle, Jerald R AD - Veterans Administration Hospital, Brockton MA 02401 Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 43 EP - 51 VL - 4 IS - 3 KW - family therapy, psychiatric hospital inpatient setting KW - Psychiatry/Psychiatric KW - Set/Sets/Settings KW - Family/Families KW - Hospital/Hospitals KW - Therapy/Therapeutic KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61465191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+Family+Counseling&rft.atitle=Working+with+Families+within+Inpatient+Settings&rft.au=Biddle%2C+Jerald+R&rft.aulast=Biddle&rft.aufirst=Jerald&rft.date=1978-07-01&rft.volume=4&rft.issue=3&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+Family+Counseling&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Family/Families; Therapy/Therapeutic; Psychiatry/Psychiatric; Hospital/Hospitals; Set/Sets/Settings ER - TY - JOUR T1 - Effects of Patient Characteristics on Delivery of Token Test Commands by Experienced and Inexperienced Examiners AN - 58069714; 8103125 AB - Recent investigations have shown that the rate of test command presentation to aphasic Ss affects their performance. Two experiments investigated whether clinicians administering the test are influenced by the patient's condition or test performance. Experiment 1 determined whether experienced examiners (EEs) or inexperienced examiners (IEs) changed their speech rate when administering the Token Test to low- & high-level patients; experiment 2 whether test commands were given at slower rates following patient errors. A test population, divided by Token Test results into low- (N = 8) & high-level (N = 5) groups, received test commands from 3 EEs & 4 IEs. T-tests indicate that EEs produced longer commands (more pause time insertions) than IEs; both used the same articulation rate; & EEs slowed their speech rates while giving repeat commands. It is suggested that the test be administered by audio recording or by clinicians with established reliability to eliminate such inconsistencies. 6 Figures. I. Mielonen JF - Journal of Communication Disorders AU - Salvatore, Anthony P AU - Strait, Marcia AU - Brookshire, Robert H AD - Veterans Administration Hospital, Phoenix AZ 85012 Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 325 EP - 333 VL - 11 IS - 4 SN - 0021-9924, 0021-9924 KW - Token Test commands delivery rate KW - aphasia level KW - experienced vs inexperienced examiners KW - Speech Rate (sp7) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58069714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Effects+of+Patient+Characteristics+on+Delivery+of+Token+Test+Commands+by+Experienced+and+Inexperienced+Examiners&rft.au=Salvatore%2C+Anthony+P%3BStrait%2C+Marcia%3BBrookshire%2C+Robert+H&rft.aulast=Salvatore&rft.aufirst=Anthony&rft.date=1978-07-01&rft.volume=11&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Speech Rate (sp7) ER - TY - JOUR T1 - The Game of the Name: An Examination of Linguistic Reference after Brain Damage AN - 58068390; 8001661 AB - Four anterior & three posterior aphasics were examined, employing 2 tasks: (1) category naming, where basic objects to a superordinate were named (eg, "Name as many __ as possible"), & (2) a variation of one of Piaget's conversation tasks, where the question "Are there more __ or more __?" was asked. In each case, one blank was a superordinate, while the other was either a high or a low prototypical base object. It was found that anterior aphasics tended to use the immediate environment for cues (eg, objects present in the room) while posterior aphasics tended to limit themselves to personal experience (eg, "We don't have a couch so I can't use that one"). Both groups were able to use both high & low prototypical items. The anterior aphasics, however, had greater reliance on high prototypical objects. Posterior aphasics showed a systematic approach, beginning with high prototypicals & proceeding towards a less prototypical point. However, posterior aphasics were less aware than anteriors of the borders of a given semantic field. The difference between the ability to grasp a single property of a concept & the ability to name an elaborated concept is considered. Aphasics with moderate damage rarely show any great difference in ability to appreciate a single property. However, the ability to utilize fully elaborated concepts requires organization of numerous properties of a semantic field & could be differentially affected by the insult locus. 1 Figure. B. Annesser JF - Brain and Language AU - Grossman, Murray AD - Psychology Research Boston Veterans Administration Hospital, 150 S Huntington Ave MA 02130 Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 112 EP - 119 VL - 6 IS - 1 SN - 0093-934X, 0093-934X KW - naming task KW - anterior vs posterior aphasics KW - Neurolinguistics (ne3a) KW - Piaget (pi1) KW - Nervous System Pathology (ne3) KW - Aphasia (ap1) KW - Onomatology, Onomastics (Name, Naming) (on1a) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=The+Game+of+the+Name%3A+An+Examination+of+Linguistic+Reference+after+Brain+Damage&rft.au=Grossman%2C+Murray&rft.aulast=Grossman&rft.aufirst=Murray&rft.date=1978-07-01&rft.volume=6&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Nervous System Pathology (ne3); Aphasia (ap1); Piaget (pi1); Onomatology, Onomastics (Name, Naming) (on1a) ER - TY - JOUR T1 - Functional foot reconditioning exercises AN - 20074783; 10092160 JF - American Journal of Sports Medicine AU - Grimes, Donald W AU - Bennion, David AU - Blush, Ken AD - Orthopaedic and Rehabilitation Departments, United States Veterans Administration Hospital, Boise, Idaho Y1 - 1978/07// PY - 1978 DA - Jul 1978 SP - 194 EP - 198 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 6 IS - 4 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Feet KW - Sports medicine KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20074783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Functional+foot+reconditioning+exercises&rft.au=Grimes%2C+Donald+W%3BBennion%2C+David%3BBlush%2C+Ken&rft.aulast=Grimes&rft.aufirst=Donald&rft.date=1978-07-01&rft.volume=6&rft.issue=4&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354657800600408 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Feet; Sports medicine DO - http://dx.doi.org/10.1177/036354657800600408 ER - TY - JOUR T1 - Considerations in the Development of the Job Placement Specialist AN - 61554655; 198001377 AB - Job placement, especially important for rehabilitation services, is defined as the process of identifying, procuring, & maintaining employment in accord with the client's needs & abilities. Gains from rehabilitation can be lost if the client cannot find suitable employment. The job placement specialist is a crucial link in the well-being of the rehabilitated disabled person. In addition to knowledge of personnel practices, employment specialists need to possess: creativity, patience, tenacity, initiative, extroversion, self-confidence, & the ability to express thoughts clearly & concisely. It is suggested that such specialists undergo psychological testing to detect these characteristics. A few Us have degree programs that emphasize job placement skills, including Southern Illinois U, Michigan State U, & Drake U. P. Montgomery. JF - Rehabilitation Literature AU - Schlenoff, David AD - Veterans Administration Regional Office, Washington DC 20420 Y1 - 1978/06// PY - 1978 DA - Jun 1978 SP - 190 EP - 191 VL - 39 IS - 6 -- 7 KW - rehabilitated disabled persons, job placement specialists, development KW - desirable characteristics, university programs KW - *Placement KW - *Job/Jobs KW - *Person/Persons KW - *Disable/Disabled/Disability/ Disabilities KW - *Rehabilitation KW - *Specialist/Specialists KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61554655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Literature&rft.atitle=Considerations+in+the+Development+of+the+Job+Placement+Specialist&rft.au=Schlenoff%2C+David&rft.aulast=Schlenoff&rft.aufirst=David&rft.date=1978-06-01&rft.volume=39&rft.issue=6+--+7&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Literature&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2012-02-15 N1 - SubjectsTermNotLitGenreText - *Rehabilitation; *Disable/Disabled/Disability/ Disabilities; *Person/Persons; *Job/Jobs; *Placement; *Specialist/Specialists ER - TY - JOUR T1 - Lesion Localization in Aphasia with Cranial Computed Tomography and the Boston Diagnostic Aphasia Exam AN - 58085461; 7903150 AB - To investigate the relationship between aphasias & their corresponding lesion sites & to determine whether the lesion site could be predicted from aphasia identification, 19 aphasics, aged thirty-four to eighty-four, were evaluated using the Boston Diagnostic Aphasia Examination (BDAE), the Token Test (TT), & by cranial computed tomography (CT). All had single left-hemisphere strokes, & were tested at least two months after aphasia onset. Tested aphasias were Broca's (N = 3), Wernicke's (N = 4), conduction N = 4), transcortical motor (N = 4), & global (N = 4). The CT localized lesions were superimposed onto five composite lesion localization maps for the five aphasias. Results indicated good r between BDAE aphasia type & lesion site. On CT scans, the locations of cortical language areas lie in a specific relationship to parts of the ventricular system. 12 Figures. Modified HA JF - Neurology AU - Naeser, Margaret A AU - Hayward, Robert W AD - Aphasia Research Unit Veterans Administration Hospital (116-B), 150 S Huntington Ave Boston MA 02130 Y1 - 1978/06// PY - 1978 DA - June 1978 SP - 545 EP - 551 VL - 28 IS - 6 SN - 0028-3878, 0028-3878 KW - lesion localization, cranial computed tomography, aphasia, Boston Diagnostic Aphasia Exam, Token Test KW - aphasics ages 34 to 84 KW - Neurolinguistics (ne3a) KW - Psycholinguistics (ps3) KW - Aphasia (ap1) KW - Biological, Physical, Physiological (bi3) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58085461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Lesion+Localization+in+Aphasia+with+Cranial+Computed+Tomography+and+the+Boston+Diagnostic+Aphasia+Exam&rft.au=Naeser%2C+Margaret+A%3BHayward%2C+Robert+W&rft.aulast=Naeser&rft.aufirst=Margaret&rft.date=1978-06-01&rft.volume=28&rft.issue=6&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEURAI N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Psycholinguistics (ps3); Aphasia (ap1); Biological, Physical, Physiological (bi3) ER - TY - JOUR T1 - Implications of Staff Absence for Effective Treatment AN - 61554938; 198000184 AB - There are few references in the mental health literature to the significant effect of staff on patient treatment. The amount of time a staff member is absent from an agency is influenced by a number of variables, many unrelated to agency administration. Absences may occur for reasons of personal consideration, professional enhancement, or community service. Accrediting agencies fail to consider absence when establishing staffing ratios; examples demonstrate that staff head counts are not reliable indicators of services available to clients. Modified AA. JF - Social Casework AU - Bowen, William T AU - Twemlow, Stuart W AD - Veterans Administration Hospital, Topeka KS 66622 Y1 - 1978/05// PY - 1978 DA - May 1978 SP - 305 EP - 308 VL - 59 IS - 5 KW - mental illness treatment, staff absence implications KW - Absence/Absences KW - Staff/Staffing KW - Implication/Implications KW - Treatment KW - Mental illness/Mentally ill KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61554938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Casework&rft.atitle=Implications+of+Staff+Absence+for+Effective+Treatment&rft.au=Bowen%2C+William+T%3BTwemlow%2C+Stuart+W&rft.aulast=Bowen&rft.aufirst=William&rft.date=1978-05-01&rft.volume=59&rft.issue=5&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Social+Casework&rft.issn=&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental illness/Mentally ill; Treatment; Staff/Staffing; Absence/Absences; Implication/Implications ER - TY - JOUR T1 - Social Work and Nursing in Hospital Settings: A Study of Interprofessional Experiences AN - 61522448; 198101770 AB - Social workers & nurses in hospitals often work together on interdisciplinary health care teams. Collaboration between these two professions can be enhanced by a better understanding of each other's roles, skills, & practice expectations, which can be acquired through opportunities to interact with individuals from the other discipline. Such interprofessional contact was measured for a sample of 237 nurses & 60 social workers employed in 4 acute care hospitals in the Seattle-Tacoma area. Questionnaires determined interprofessional contacts prior to professional education, during formal training, & since engagement in the profession. Although these professions generally showed little contact with the other, such contact did increase with actual employment. 3 Tables, 1 Figure. Modified HA. JF - Social Work in Health Care AU - Williams, Cindy Cook AU - Bracht, Neil F AU - Williams, Reg Arthur AU - Evans, Ron L AD - Veterans Administration Hospital, Seattle WA 98108 Y1 - 1978/04// PY - 1978 DA - April 1978 SP - 311 EP - 322 VL - 3 IS - 3 SN - 0098-1389, 0098-1389 KW - interprofessional contact, nurses/social workers, hospital settings KW - questionnaires, Seattle-Tacoma KW - Inter -- KW - Social work KW - Nurse/Nurses/Nursing KW - Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized KW - Hospital/Hospitals KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61522448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Social+Work+and+Nursing+in+Hospital+Settings%3A+A+Study+of+Interprofessional+Experiences&rft.au=Williams%2C+Cindy+Cook%3BBracht%2C+Neil+F%3BWilliams%2C+Reg+Arthur%3BEvans%2C+Ron+L&rft.aulast=Williams&rft.aufirst=Cindy&rft.date=1978-04-01&rft.volume=3&rft.issue=3&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social work; Nurse/Nurses/Nursing; Hospital/Hospitals; Inter --; Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized ER - TY - JOUR T1 - A Concept of Loneliness in the Elderly AN - 60637105; 80L1224 AB - The concept of loneliness is described, especially as it concerns the elderly. An attempt is made to develop an understanding of the word, with its implications for guidance in the nursing profession. The nurses' personal defenses against feelings of loneliness & depression can inhibit therapeutic interactions with lonely or depressed patients. Appropriate nursing action depends upon the knowledge, correlation, & use of many other concepts, eg, those related to dynamics of behavior, personality structure, & development or problem solving. Practical recommendations for nursing intervention are outlined. Emphasized is the necessity for the nurse to understand the concept of loneliness in order to render effective service. HA. JF - Journal of the American Geriatrics Society AU - Williams, Lula M AD - Veterans Administration Hospital, Nashville TN 37208 Y1 - 1978/04// PY - 1978 DA - April 1978 SP - 183 EP - 187 VL - 26 IS - 4 SN - 0002-8614, 0002-8614 KW - elderly, loneliness concept, nursing profession implications KW - intervention recommendations KW - Loneliness KW - Elder/Elders/Elderly KW - Nurse/Nurses/Nursing KW - Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized KW - Concept/Concepts/Conception/Conceptual/ Conceptualization KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60637105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=A+Concept+of+Loneliness+in+the+Elderly&rft.au=Williams%2C+Lula+M&rft.aulast=Williams&rft.aufirst=Lula&rft.date=1978-04-01&rft.volume=26&rft.issue=4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Elder/Elders/Elderly; Loneliness; Concept/Concepts/Conception/Conceptual/ Conceptualization; Nurse/Nurses/Nursing; Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized ER - TY - JOUR T1 - The Time, Amount, and Pattern of Language Improvement in Adult Aphasics AN - 58072813; 7905981 AB - Thirteen adult aphasics (all having had left-hemisphere CVA) were administered the Porch Index of Communicative Ability (PICA) at intervals throughout language rehabilitation (mean duration 9.0 months). The time, amount, & pattern of change in PICA subtest scores were investigated. All subtest scores showed positive change. The average time required for peak improvement in overall score was 8.94 months postonset. Receptive lang processes improved more quickly & completely than expressive. The course of lang recovery appears somewhat predictable in terms of time, amount, & pattern of improvement. Amount of language recovery was found related to the aphasia's severity at therapy onset, as was the completeness of recovery. Patients with the highest initial scores reached the highest improvement level, but patients with lower initial scores also showed significant recovery. 4 Tables. Modified HA JF - The British Journal of Disorders of Communication AU - Hanson, W R AU - Cicciarelli, A W AD - Veterans Administration Hospital, Sepulveda CA 91343 Y1 - 1978/04// PY - 1978 DA - April 1978 SP - 59 EP - 63 VL - 13 IS - 1 SN - 0007-098X, 0007-098X KW - language recovery patterns KW - adult aphasics KW - Communication in Groups (co3) KW - Speech Therapy (sp13) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58072813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Disorders+of+Communication&rft.atitle=The+Time%2C+Amount%2C+and+Pattern+of+Language+Improvement+in+Adult+Aphasics&rft.au=Hanson%2C+W+R%3BCicciarelli%2C+A+W&rft.aulast=Hanson&rft.aufirst=W&rft.date=1978-04-01&rft.volume=13&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Disorders+of+Communication&rft.issn=0007098X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJDCBU N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Pathology (la4); Communication in Groups (co3); Speech Therapy (sp13) ER - TY - JOUR T1 - Current Trends in Sex Education Programming for the Physically Disabled: Some Guidelines for Implementation and Evaluation AN - 1761728948; 197900480 AB - The status of sex education programming for the physically disabled is reviewed. Audiovisual aids used in some of these programs are listed & some guidelines are provided for implementing & evaluating programs. Program formats are discussed & factors involved in establishing a program are cited as: method for selecting patients, methods of staff selection & training, & the type of program to be offered. Also discussed are the times at which program evaluations should be made. Modified HA. JF - Sexuality and Disability AU - Eisenberg, M G AU - Falconer, J AD - Veterans Administration Hospital, Cleveland OH 44106 Y1 - 1978/04// PY - 1978 DA - April 1978 SP - 6 EP - 15 VL - 1 IS - 1 SN - 0146-1044, 0146-1044 KW - Handicapped KW - Educational Programs KW - Sex Education KW - Program Evaluation KW - article KW - 6150: professional issues in social work UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761728948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexuality+and+Disability&rft.atitle=Current+Trends+in+Sex+Education+Programming+for+the+Physically+Disabled%3A+Some+Guidelines+for+Implementation+and+Evaluation&rft.au=Eisenberg%2C+M+G%3BFalconer%2C+J&rft.aulast=Eisenberg&rft.aufirst=M&rft.date=1978-04-01&rft.volume=1&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Sexuality+and+Disability&rft.issn=01461044&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Sex Education; Handicapped; Educational Programs; Program Evaluation ER - TY - JOUR T1 - Aphasic and amnesic patients' verbal vs. nonverbal retentive abilities. AN - 74481004; 16295107 AB - Four different groups of patients (aphasics, alcoholic Korsakoffs, chronic alcoholics, and control patients) were asked to detect either repeated words presented orally, repeated words presented visually, repeated pictures or repeated shapes, during the presentation of a list of similarly constructed stimuli. It was discovered that on the verbal tasks, the number of words intervening between repetitions had more effect on the aphasics than on the other groups of patients. However, for the nonverbal picture repetition and shape repetition tasks, the aphasics' performance was normal, while the alcoholic Korsakoff patients were most affected by the number of intervening items. It was concluded that the aphasics' memory deficit demonstrated by the use of this paradigm was specific to the presentation of verbal material. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Cermak, L S AU - Tarlow, S AD - Psychology Service, Boston Veterans Administration Hospital, and Aphasia Research Unit, Neurology Department, Boston University School of Medicine, Mass. 02130, USA. Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 32 EP - 40 VL - 14 IS - 1 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - Psycholinguistics KW - Korsakoff Syndrome -- psychology KW - Humans KW - Aged KW - Male KW - Female KW - Aphasia, Broca -- psychology KW - Aphasia -- psychology KW - Memory -- physiology KW - Verbal Learning -- physiology KW - Amnesia -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74481004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Aphasic+and+amnesic+patients%27+verbal+vs.+nonverbal+retentive+abilities.&rft.au=Cermak%2C+L+S%3BTarlow%2C+S&rft.aulast=Cermak&rft.aufirst=L&rft.date=1978-03-01&rft.volume=14&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-07 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex-Role Learning: A Test of the Selective Attention Hypothesis AN - 61053449; 81L3353 AB - Both social learning & cognitive-developmental theories propose that acquisition of sex-role knowledge depends upon some mechanism of selective attention to same-sex models. In two experiments, pictures of a male & a female model performing matched acts were shown, & visual attention was assessed by the method of feedback electroencephalography (EEG). Recall & preference for the slides were also measured. In both experiments, 48 children (ages 5-6 & 8-10) viewed models performing sex-appropriate, sex-inappropriate, & sex-neutral tasks. No difference was found in the EEG attentional measures for the male versus female slides. In experiment 1, the children recalled & preferred the same-sex task & preferred the same-sex model. In experiment 2, the children, regardless of gender, recalled more of the male than the female slides. Males preferred the male tasks while females preferred male & female tasks equally. There is no evidence for selective attention to same-sex models. 1 Table. Modified HA. JF - Child Development AU - Bryan, Janice Westlund AU - Luria, Zella AD - Veterans Administration Hospital, Bedford MA 01730 Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 13 EP - 23 VL - 49 IS - 1 SN - 0009-3920, 0009-3920 KW - sex-role learning, selective attention hypothesis KW - feedback electroencephalography (EEG), picture recall/preference KW - male/female models, sex appropriate/inappropriate/neutral tasks KW - children, aged 5-6/8-10 KW - Hypothesis/Hypotheses/ Hypothetic/ Hypothetical KW - Select/Selective/Selectivity/ Selection/ Selecting KW - Sex role/Sex roles KW - Attention KW - Learning/Learned KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61053449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development&rft.atitle=Sex-Role+Learning%3A+A+Test+of+the+Selective+Attention+Hypothesis&rft.au=Bryan%2C+Janice+Westlund%3BLuria%2C+Zella&rft.aulast=Bryan&rft.aufirst=Janice&rft.date=1978-03-01&rft.volume=49&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Child+Development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - CHDEAW N1 - SubjectsTermNotLitGenreText - Sex role/Sex roles; Learning/Learned; Select/Selective/Selectivity/ Selection/ Selecting; Attention; Hypothesis/Hypotheses/ Hypothetic/ Hypothetical ER - TY - JOUR T1 - Serum Testosterone and Sexual Activity and Interest in Men AN - 60814440; 79J9086 AB - Despite interest in the possibility that testosterone levels influence M sexual interest & activity, existing research data is inconclusive. Reported is an attempt to identify & clarify the relationsip among components of sexual behavior & the observed testosterone concentrations for 101 healthy M Ss. In order to determine individual serum testosterone concentration levels, two blood samples were taken from each S at a one-week interval. At the time of the first blood test, Ss were administered several inventories, including the Marlowe-Crowne Social Desirability Scale. Ss also completed a questionnaire regarding type & frequency of sexual experience, weekly frequency of orgasm (through coitus, masturbation, & other means), daily frequency of sexual thoughts, & the nonmedical use of drugs. Although Ss varied widely both in mean testosterone levels & reported sexual activity, no correlation between testosterone concentration & sexual variable frequencies was found. Hence, hormonal factors are of little importance in determining patterns of M sexual behavior. 1 Table, Appendix. P. Hoye. JF - Archives of Sexual Behavior AU - Brown, Walter Armin AU - Monti, Peter M AU - Corriveau, Donald P AD - Brown U, Providence RI 02908 & Veterans Administration Hospital, Providence RI 02908 Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 97 EP - 103 VL - 7 IS - 2 SN - 0004-0002, 0004-0002 KW - male sexual activity, interest, serum testosterone levels correlation KW - intra-individual consistency, noncorrelation KW - Marlowe-Crowne Sexual Desirability Scale KW - Sexual/Sexuality/Sexually KW - Behavior/Behavioral KW - Endocrine/Endocrines KW - Interest/Interests KW - Male/Males (see also Man) KW - article KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60814440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Serum+Testosterone+and+Sexual+Activity+and+Interest+in+Men&rft.au=Brown%2C+Walter+Armin%3BMonti%2C+Peter+M%3BCorriveau%2C+Donald+P&rft.aulast=Brown&rft.aufirst=Walter&rft.date=1978-03-01&rft.volume=7&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASXBA8 N1 - SubjectsTermNotLitGenreText - Sexual/Sexuality/Sexually; Interest/Interests; Male/Males (see also Man); Endocrine/Endocrines; Behavior/Behavioral ER - TY - JOUR T1 - Alcoholic Korsakoff Patients' Retrieval from Semantic Memory AN - 58080451; 7901458 AB - Five studies were conducted on the semantic memory of alcoholic Korsakoff patients. In experiment 1, 11 Korsakoff & 11 alcoholic control Ss participated in a verbal reaction time test showing no significant differences between the two groups. Experiment 2 showed a slight but nonsignificant difference between groups (11 different alcoholic controls) on a reading-decision task. Experiment 3 (12 Korsakoff patients & 12 different alcoholic controls) involved presentation of category plus initial letter, with S required to say the word aloud as soon as he thought of it. A larger but still nonsignificant difference was found between groups in speed of locating items. In experiment 4 (9 of the previous Korsakoff Ss plus 9 new controls), a descriptive adj was used in place of an initial letter clue with the category name; this time a significant difference was found. Results support the notion of two semantic memory components - the lexicon where items are represented according to phonemic or orthographic similarity, & the conceptual semantic memory organized by semantic similarities between items. The latter function was apparently tapped by experiment 4 & represents an area where Korsakoff patients do not do as well as normals. In experiment 5, forty new items from ten categories were added to the experiment 3 task, with the difference that the same category appeared more than once in the test with different initial letter cues & was separated from the previous occurrence by zero, one, two, or three intervening pairs. Korsakoff patients, unlike controls, showed no priming effect. Thus, lexical semantic memory was apparently not activated by an immediately previous search of the same category, ie, there was no interaction between episodic & semantic memory. Lexical organization apparently remains intact in Korsakoff patients while the conceptual network is damaged to some extent. 5 Tables. B. Annesser JF - Brain and Language AU - Cermak, Laird S AU - Reale, Lynn AU - Baker, Errol AD - Boston Veterans Administration Hospital, 150 S Huntington Ave MA 02130 Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 215 EP - 226 VL - 5 IS - 2 SN - 0093-934X, 0093-934X KW - episodic vs semantic memory KW - category name, initial letter vs descriptive adjective clue KW - normal, Korsakoff alcholics KW - Adjective (ad1) KW - Psycholinguistics (ps3) KW - Memory (me3) KW - Semantics (se9) KW - Verbal Learning (ve2) KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58080451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Alcoholic+Korsakoff+Patients%27+Retrieval+from+Semantic+Memory&rft.au=Cermak%2C+Laird+S%3BReale%2C+Lynn%3BBaker%2C+Errol&rft.aulast=Cermak&rft.aufirst=Laird&rft.date=1978-03-01&rft.volume=5&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Semantics (se9); Language Pathology (la4); Memory (me3); Nervous System Pathology (ne3); Verbal Learning (ve2); Psycholinguistics (ps3); Adjective (ad1) ER - TY - JOUR T1 - Comprehension Disorders in Aphasia: A Historical Review AN - 58068281; 7902840 AB - A historical review of research on the comprehension disorders found in aphasia is presented. Work discussed includes the early work of Lordat up to the work of P. Marie & A. Pick. Early contributions to testing of comprehension disorders in aphasia & diagnosis are outlined. It is shown that current work on comprehension disorders in aphasia owes a great deal to earlier pioneering studies. 7 Figures. B. Annesser JF - Brain and Language AU - Boller, Francois AD - Cleveland Veterans Administration Hospital, 10701 East Blvd Cleveland OH 44106 Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 149 EP - 165 VL - 5 IS - 2 SN - 0093-934X, 0093-934X KW - aphasia, comprehension disorders, historical review KW - Neurolinguistics (ne3a) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Comprehension+Disorders+in+Aphasia%3A+A+Historical+Review&rft.au=Boller%2C+Francois&rft.aulast=Boller&rft.aufirst=Francois&rft.date=1978-03-01&rft.volume=5&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1); Neurolinguistics (ne3a) ER - TY - JOUR T1 - Retrieval Failure, Rehearsal Deficiency, and Short-Term Memory Loss in the Aphasic Adult AN - 58068061; 7902858 AB - Five aphasic Ss were shown pictures that they were able to name quickly & accurately, or were unable to name at all. In naming sessions, two picture lists were derived for each S. Each list consisted of three easily named items (N) & three that were never named (U). A memory task involving N & U lists was administered to the aphasic Ss & to three normal controls. Overall recall accuracy was nearly identical for the two lists for aphasic Ss; however, recall was not the same across the three list positions: identical recall was found at position three, consistent with the hypothesis that performance would be similar for the two list types of list-final items. It appears that the ability to rehearse verbally was damaged in the aphasic Ss, & that the list-position effect was related to the rehearsal deficit. From the fact that a primary effect was found only for the N lists, it is inferred that Ss did rehearse, but that rehearsal was somehow impaired & did not elevate overall performance. 1 Table, 1 Figure. B. Annesser JF - Brain and Language AU - Locke, John L AU - Deck, John W AD - Instit Child Behavior Development U Illinois, Champaign 61820 & Veterans Administration Hospital, Danville IL 61832 Y1 - 1978/03// PY - 1978 DA - March 1978 SP - 227 EP - 235 VL - 5 IS - 2 SN - 0093-934X, 0093-934X KW - short-term memory, verbal rehearsal KW - list-final vs nonfinal items KW - aphasic patients KW - Rehearsal (Verbal Learning Strategy) (re8a) KW - Psycholinguistics (ps3) KW - Memory (me3) KW - Short-Term Memory (sh2) KW - Language Pathology (la4) KW - Nervous System Pathology (ne3) KW - Learning Disabilities (la16) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Retrieval+Failure%2C+Rehearsal+Deficiency%2C+and+Short-Term+Memory+Loss+in+the+Aphasic+Adult&rft.au=Locke%2C+John+L%3BDeck%2C+John+W&rft.aulast=Locke&rft.aufirst=John&rft.date=1978-03-01&rft.volume=5&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Nervous System Pathology (ne3); Language Pathology (la4); Psycholinguistics (ps3); Rehearsal (Verbal Learning Strategy) (re8a); Learning Disabilities (la16); Memory (me3); Short-Term Memory (sh2) ER - TY - JOUR T1 - A Study of Repetition in Aphasic Patterns AN - 85439520; 8002964 AB - A detailed study of repetition in aphasic patients was designed to account for such factors as the variety of aphasia types. Various item types were sampled. Repetition was examined under both immediate & delayed response conditions. Performance was evaluated in terms of number of errors & analysis of error type. Ss were 44 patients with left-hemisphere damage. Seventeen were anterior aphasics, 14 posterior aphasics, & 12 conduction aphasics; 1 S had a mixed transcortical syndrome. The test consisted of 79 items combining various lengths & types of stimulus. The Ss' overall performance on the two repetition conditions was found to reflect their symptomatology. Transcriptional aphasics showed the best overall prformance, conduction aphasics & mixed anteriors the worst. However, the relative difficulty of various item types was very similar across patient groups & did not vary much over response conditions. A qualitative difference is suggested by some data, such that it is proposed that repetition is a "more active & constructive process" for conduction aphasics than it is for other groups. 2 Figures. B. Annesser JF - Brain and Language AU - Gardner, Howard AU - Winner, Ellen AD - Boston Veterans Administration Hospital, 150 S Huntington Ave MA 02130 Y1 - 1978///0, PY - 1978 DA - 0, 1978 SP - 168 EP - 178 VL - 6 IS - 2 SN - 0093-934X, 0093-934X KW - repetition performance KW - delayed vs immediate response KW - anterior vs posterior vs conduction aphasics KW - Language Pathology (la4) KW - Nervous System Pathology (ne3) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85439520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=A+Study+of+Repetition+in+Aphasic+Patterns&rft.au=Gardner%2C+Howard%3BWinner%2C+Ellen&rft.aulast=Gardner&rft.aufirst=Howard&rft.date=1978-01-01&rft.volume=6&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Nervous System Pathology (ne3); Language Pathology (la4) ER - TY - JOUR T1 - A Token Test Battery for Testing Auditory Comprehension in Brain-Injured Adults AN - 85436387; 8001656 AB - An auditory comprehension test battery based on the original Token Test is described. Three basic test conditions were used: standard, configurational, & visual. Each was administered under 2 response modes: immediate & delayed. The standard condition used the same tokens described in the original Token Test except that squares were used in place of rectangles. In the configurational condition, Ss were required to select one of several cards which contained the same configuration of objects as the spoken command. In the visual condition, Ss viewed a card containing 1 or more tokens representing a command from the original test & were asked to select an identical card from among 4 choices. Ss were 25 patients with left-hemispheric damage & aphasia, & 10 non-brain-damaged patients. Aphasic Ss showed gradual improvement in performance from standard to configuration to visual conditions. Their performance was worse in delayed response mode than in immediate response mode. A method of comparing a given S's performance with either the left-hemisphere-damaged or right-hemisphere-damaged group was devised. It was found that as a whole, inclusion of the delayed response condition was not warranted in terms of providing differentiation between right- & left-hemisphere-damaged patients. Both groups performed better on the immediate-response condition than on the delay-response condition. 2 Tables, 5 Figures. B. Annesser JF - Brain and Language AU - Brookshire, Robert H AD - Veterans Administration Hospital, Minneapolis MN 55417 Y1 - 1978///0, PY - 1978 DA - 0, 1978 SP - 149 EP - 157 VL - 6 IS - 2 SN - 0093-934X, 0093-934X KW - Token Test based auditory comprehension testing KW - standard vs visual configuration KW - brain-injured adults KW - Neurolinguistics (ne3a) KW - Listening Comprehension (li4) KW - Nervous System Pathology (ne3) KW - Testing (te7) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85436387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=A+Token+Test+Battery+for+Testing+Auditory+Comprehension+in+Brain-Injured+Adults&rft.au=Brookshire%2C+Robert+H&rft.aulast=Brookshire&rft.aufirst=Robert&rft.date=1978-01-01&rft.volume=6&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Listening Comprehension (li4); Neurolinguistics (ne3a); Nervous System Pathology (ne3); Testing (te7) ER - TY - JOUR T1 - The Effects of Rate Variability on the Auditory Processing Ability of Aphasic Patients AN - 85433198; 8000146 AB - Investigated was the effect of variations in utterance rate & length on aphasic patients' ability to process verbal communications. Ss were 10 adult M aphasics in a Veterans Administration Hospital; controls were 10 normal adult Ms, hospitalized for problems other than communicative. Time-altered speech (compressed & expanded) was used to evaluate the effect of rate variability on auditory processing ability of aphasics. It was determined that slower than normal (expanded) speech was processed or understood better by aphasics than was speech delivered at a normal or faster rate. Performance of aphasics deteriorated as utterance length increased. The effect of variations in both rate & utterance length was minimial for controls. 1 Table, 1 Figure. HA JF - Acta Symbolica AU - Simpson, Robert K AU - Canetta, Robert AD - Veterans Administration Hospital, Danville IL 61832 Y1 - 1978///0, PY - 1978 DA - 0, 1978 SP - 51 EP - 62 VL - 9 IS - 2 KW - auditory processing ability KW - utterance rate, length KW - aphasic adults KW - Speech Rate (sp7) KW - Neurolinguistics (ne3a) KW - Psycholinguistics (ps3) KW - Audiology (au2) KW - Aphasia (ap1) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85433198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Symbolica&rft.atitle=The+Effects+of+Rate+Variability+on+the+Auditory+Processing+Ability+of+Aphasic+Patients&rft.au=Simpson%2C+Robert+K%3BCanetta%2C+Robert&rft.aulast=Simpson&rft.aufirst=Robert&rft.date=1978-01-01&rft.volume=9&rft.issue=2&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Acta+Symbolica&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ACSYCA N1 - SubjectsTermNotLitGenreText - Neurolinguistics (ne3a); Speech Rate (sp7); Aphasia (ap1); Audiology (au2); Psycholinguistics (ps3) ER - TY - JOUR T1 - Current considerations in digoxin usage. AN - 74422711; 401374 AB - Basic considerations in biotransformation and pharmacodynamics are presented as a basis for understanding clinical usage. The role of polarity in determining a given glycoside's duration of action and extent of biotransformation is emphasized. The pharmacokinetics are summarized emphasizing the fact that digoxin is not completely absorbed by oral administration. The important relationship of serum digoxin levels to myocardial content and apparently to myocardial response is reviewed. This relationship and the development of precise methods for measurement of digoxin in serum provide the clinician with accurate means to assess myocardial tolerance for digoxin under diverse clinical circumstances. This review includes discussion of methods of digitalization, appropriate use of serum levels, apparent and real resistance to digoxin, and apparent and real sensitivity to digoxin. The limitations of serum levels as a precise guide to toxicity are analyzed. Finally, new developments in use of immunologic therapy for digoxin intoxication are presented. JF - CRC critical reviews in clinical laboratory sciences AU - Shapiro, W AD - Dallas Veterans Administration Hospital, Texas. Y1 - 1978 PY - 1978 DA - 1978 SP - 321 EP - 346 VL - 9 IS - 4 SN - 0590-8191, 0590-8191 KW - Digoxin KW - 73K4184T59 KW - Digitoxin KW - E90NZP2L9U KW - Index Medicus KW - Digitoxin -- metabolism KW - Arrhythmias, Cardiac -- chemically induced KW - Dose-Response Relationship, Drug KW - Biotransformation KW - Humans KW - Middle Aged KW - Myocardium -- metabolism KW - Digitoxin -- pharmacokinetics KW - Biological Availability KW - Digoxin -- pharmacokinetics KW - Digoxin -- metabolism KW - Digoxin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74422711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CRC+critical+reviews+in+clinical+laboratory+sciences&rft.atitle=Current+considerations+in+digoxin+usage.&rft.au=Shapiro%2C+W&rft.aulast=Shapiro&rft.aufirst=W&rft.date=1978-01-01&rft.volume=9&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=CRC+critical+reviews+in+clinical+laboratory+sciences&rft.issn=05908191&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-16 N1 - Date created - 1990-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Touching: A Legacy from the Encounter Movement for Social Work Practice AN - 61568062; 198200174 AB - Human touching within helping relationships became especially prominent during the so-called encounter movement of the late 1960s & early 1970s. This indeed may be the movement's major legacy to clinical social work work practice. The social conditions that encouraged the use of touch as therapy are examined, & the possibilities are evaluated of person-to-person tactile contact becoming an acceptable intervention in psychiatric & medical settings. Modified HA. JF - Social Work in Health Care AU - Bogdanoff, Marvin AU - Elbaum, Phillip L AD - Hines Veterans Administration Hospital, IL 60141 Y1 - 1978/01// PY - 1978 DA - January 1978 SP - 209 EP - 219 VL - 4 IS - 2 SN - 0098-1389, 0098-1389 KW - social work practice, human touching KW - encounter movement's legacy, therapy KW - Encounter/Encounters KW - Practice/Practices KW - Social work KW - Movement/Movements KW - Therapy/Therapeutic KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61568062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Touching%3A+A+Legacy+from+the+Encounter+Movement+for+Social+Work+Practice&rft.au=Bogdanoff%2C+Marvin%3BElbaum%2C+Phillip+L&rft.aulast=Bogdanoff&rft.aufirst=Marvin&rft.date=1978-01-01&rft.volume=4&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social work; Practice/Practices; Encounter/Encounters; Movement/Movements; Therapy/Therapeutic ER - TY - JOUR T1 - Relationships among Control Orientation, the FIRO-B, and the Ward Atmosphere Scale in Hospitalized Men Alcoholics AN - 61435663; 198100637 AB - Fifty-four male alcoholics, admitted to a hospital treatment program, participated in a study designed to analyze their control orientation. Internally-oriented patients' scores on Rotter's Internal-External Locus of Control Scale remained the same over a 5-week treatment period, but those of externally-oriented patients shifted toward greater internal control. 2 Tables. Modified HA. JF - Journal of Studies on Alcohol AU - Greenberg, Edward A AU - Obitz, Frederick W AU - Kaye, Bruce W AD - Veterans Administration Hospital, Phoenix AZ 85012 Y1 - 1978/01// PY - 1978 DA - January 1978 SP - 68 EP - 76 VL - 39 IS - 1 SN - 0096-882X, 0096-882X KW - alcoholics, hospitalized males KW - Rotter's Internal-External Locus of Control Scale KW - Control/Controls/Controlled KW - Hospitalization KW - Alcoholic/Alcoholics/Alcoholism KW - article KW - 6120: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61435663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Relationships+among+Control+Orientation%2C+the+FIRO-B%2C+and+the+Ward+Atmosphere+Scale+in+Hospitalized+Men+Alcoholics&rft.au=Greenberg%2C+Edward+A%3BObitz%2C+Frederick+W%3BKaye%2C+Bruce+W&rft.aulast=Greenberg&rft.aufirst=Edward&rft.date=1978-01-01&rft.volume=39&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Alcoholic/Alcoholics/Alcoholism; Control/Controls/Controlled; Hospitalization ER - TY - JOUR T1 - Scaling Procedures in Life Events Research AN - 60675297; 80K4048 AB - Research into the relationship of life events & symptoms has increasingly utilized various techniques to estimate the magnitude of anticipated impact of such events. Four procedures for scaling events from Holmes & Rahe's Schedule of Recent Experience (SRE) were examined: (1) simple count of life events, (2) life change units (LCU) computed from Social Readjustment Rating Scale (SRRS) norms, (3) LCUs based on group-specific SRRS values derived from psychiatric patients (number of cases = 357) & nonpatients (number of cases = 250), & (4) LCUs based on each individual's own SRRS values. Although event scaling methods yielded strong event-symptom correlations, none was significantly better than the simple count of life events. The a priori validity of weighting events based on their perceived impact may be counterbalanced by the error variance introduced by the SRRS instrument itself. 3 Tables. Modified HA. JF - Journal of Psychosomatic Research AU - Grant, Igor AU - Sweetwood, Hervey AU - Gerst, Marvin S AU - Yager, Joel AD - Psychiatry Service Veterans Administration Hospital, San Diego CA 92161 Y1 - 1978///0, PY - 1978 DA - 0, 1978 SP - 525 EP - 530 VL - 22 IS - 6 SN - 0022-3999, 0022-3999 KW - life events research, scaling procedure KW - Holmes/Rahe's Schedule of Recent Experiences KW - Procedure/Procedures/Procedural KW - Life (see also Living) KW - Research/Researcher/Researchers KW - Scaling KW - article KW - 0105: methodology and research technology; statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60675297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Scaling+Procedures+in+Life+Events+Research&rft.au=Grant%2C+Igor%3BSweetwood%2C+Hervey%3BGerst%2C+Marvin+S%3BYager%2C+Joel&rft.aulast=Grant&rft.aufirst=Igor&rft.date=1978-01-01&rft.volume=22&rft.issue=6&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPCRAT N1 - SubjectsTermNotLitGenreText - Life (see also Living); Research/Researcher/Researchers; Scaling; Procedure/Procedures/Procedural ER - TY - JOUR T1 - Sentence and Spondee Stimuli: Responses of Hearing Impaired Children AN - 85441153; 7904497 AB - It is necessary for a child learning language to have a model; usually the parent assumes this role. This cannot be the case for deaf children, however: they do not have the same sort of stimuli & must be taught language differently. To test their responses to short length stimuli (spondees) & greater length stimuli (sentences), tests were done with 21 hearing-impaired children aged nine to twelve. Stimuli were presented in three modes: a live speech mode, a synthetic speech mode, & a transposed synthetic speech mode. Mean errors & deviations were recorded & tabulated. It was concluded from results that those with hearing losses responded better & more accurately on synthetic & live speech modes & with longer stimuli - these present more data for information processing, & the message is better perceived. As with normal-hearing children, a deaf child requires longer stimuli for better language acquisition. 2 Tables. Modified HA JF - American Annals of the Deaf AU - Fleming, Susan M AU - McClung, John A AU - Allen, Doris V AD - Veterans Administration Hospital, Allen Park MI 48101 Y1 - 1977/12// PY - 1977 DA - December 1977 SP - 553 EP - 556 VL - 122 IS - 6 SN - 0002-726X, 0002-726X KW - response accuracy, quality KW - live vs synthetic vs transposed synthetic speech mode KW - hearing-impaired 9- to 12-year-olds KW - Hearing Disorders (he3a) KW - Audiology (au2) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Annals+of+the+Deaf&rft.atitle=Sentence+and+Spondee+Stimuli%3A+Responses+of+Hearing+Impaired+Children&rft.au=Fleming%2C+Susan+M%3BMcClung%2C+John+A%3BAllen%2C+Doris+V&rft.aulast=Fleming&rft.aufirst=Susan&rft.date=1977-12-01&rft.volume=122&rft.issue=6&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=American+Annals+of+the+Deaf&rft.issn=0002726X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ANDFAL N1 - SubjectsTermNotLitGenreText - Audiology (au2); Hearing Disorders (he3a) ER - TY - JOUR T1 - An Evaluation of the Use of the Law in a Free Society Materials on 'Responsibility' AN - 61525216; 197900773 AB - Students in grades seven, eight, & nine (N=300) took two achievement tests & one attitudinal test before the introduction of the 'Responsibility' materials to the experimental group. The object of the study was to investigate whether the use of materials on responsibility would: (1) influence student achievement scores on tests measuring understanding of various aspects of responsibility, & (2) generate more positive attitudes toward responsibility in the students. After one week's use of the responsibility unit, the tests were again administered to the same students. A three-way (grades X ability groups X programs) multivariate analysis of variance of gain scores was performed to test the hypotheses. Only the differences between programs were found to be significant. Those differences could be attributed to a slight but significant increase in the attitudinal-test scores of the experimental group. One week of teaching was not enough to make either a positive or negative impact. Further research is recommended. 4 Tables. Modified HA. JF - Evaluation Quarterly AU - Singh, Balwant AU - Greer, Peter R AU - Hammond, Richard AD - Portland Public Schools, ME 04101 & Veterans Administration, Washington DC 20420 Y1 - 1977/11// PY - 1977 DA - November 1977 SP - 621 EP - 628 VL - 1 IS - 4 SN - 0145-4692, 0145-4692 KW - Student Attitudes KW - Law Enforcement KW - Academic Achievement KW - Attitude Change KW - Junior High School Students KW - Social Responsibility KW - article KW - 7220: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61525216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+Quarterly&rft.atitle=An+Evaluation+of+the+Use+of+the+Law+in+a+Free+Society+Materials+on+%27Responsibility%27&rft.au=Singh%2C+Balwant%3BGreer%2C+Peter+R%3BHammond%2C+Richard&rft.aulast=Singh&rft.aufirst=Balwant&rft.date=1977-11-01&rft.volume=1&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Evaluation+Quarterly&rft.issn=01454692&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Responsibility; Law Enforcement; Academic Achievement; Junior High School Students; Student Attitudes; Attitude Change ER - TY - JOUR T1 - Demographic and Clinical Characteristics as Predictors of Length of Hospitalization and Readmission AN - 60681549; 80K9649 AB - Demographic & clinical characteristics (21 variables) of psychiatric patients were investigated in relation to the 2 criterion variables of length of hospitalization & readmission within 3 months of discharge. The 202 subjects were patients admitted to 5 general psychiatric treatment units at a Veterans Administration Hospital. Stepwise multiple regression analysis identified 5 variables as the optimal set of predictors for length of hospitalization, & 6 variables predicting readmission within 3 months of discharge. Implications of the findings for identifying short-term treatment candidates & factors related to readmission are discussed. 2 Tables. Modified HA. JF - Journal of Clinical Psychology AU - Munley, Patrick H AU - Devone, Nicholas AU - Einhorn, Carl M AU - Gash, Ira A AU - Hyer, Leon AU - Kuhn, Kenneth C AD - Veterans Administration Hospital, Lyons NJ 07939 Y1 - 1977/10// PY - 1977 DA - October 1977 SP - 1093 EP - 1099 VL - 33 IS - 4 SN - 0021-9762, 0021-9762 KW - psychiatric patients, length of hospitalization/readmission, demographic/clinical characteristics as predictors KW - Veterans Administration Hospital KW - Clinic/Clinics/Clinical/Clinician KW - Patient/Patients KW - Psychiatry/Psychiatric KW - Hospitalization KW - Characteristic/Characteristics KW - Demography/Demographic/ Demographical KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60681549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Demographic+and+Clinical+Characteristics+as+Predictors+of+Length+of+Hospitalization+and+Readmission&rft.au=Munley%2C+Patrick+H%3BDevone%2C+Nicholas%3BEinhorn%2C+Carl+M%3BGash%2C+Ira+A%3BHyer%2C+Leon%3BKuhn%2C+Kenneth+C&rft.aulast=Munley&rft.aufirst=Patrick&rft.date=1977-10-01&rft.volume=33&rft.issue=4&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Psychiatry/Psychiatric; Patient/Patients; Hospitalization; Demography/Demographic/ Demographical; Clinic/Clinics/Clinical/Clinician; Characteristic/Characteristics ER - TY - JOUR T1 - Sex-Role Ideology, Selected Life Plans, and Family Size Preferences: Further Evidence AN - 60677948; 80K5094 AB - The sex-role ideology of a sample of female, high school seniors was related to their educational aspirations, expected age at marriage, & family size preference. Questionniares were distributed in 7 suburban public schools in metropolitan Atlanta, Ga, during spring 1973, to 450 senior girls. The final sample consisted of 388 white, non-Catholic girls with somewhat higher than average income & white-collar backgrounds. It was found that women with a contemporary view of the feminine role aspire to higher educational goals, expect to marry at a later age, & both desire & expect fewer children than traditionally-oriented women. Sex-role orientation was found to be more strongly related to family size preferences than either educational aspirations or expected age at marriage. 3 Tables, Appendix. Modified AA. JF - Journal of Comparative Family Studies AU - Wrigley, Alice P AU - Stokes, C Shannon AD - Veterans Administration Pennsylvania State U, University Park 16802 Y1 - 1977/10// PY - 1977 DA - October 1977 SP - 391 EP - 400 VL - 8 IS - 3 SN - 0047-2328, 0047-2328 KW - sex-role ideology, educational/family aspirations, female high school seniors KW - white, non-Catholic, white collar background, Atlanta, Georgia KW - High school/High schools KW - Female/Females (see also Woman) KW - Ideology/Ideologies/Ideological KW - Sex role/Sex roles KW - Student/Students KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60677948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Family+Studies&rft.atitle=Sex-Role+Ideology%2C+Selected+Life+Plans%2C+and+Family+Size+Preferences%3A+Further+Evidence&rft.au=Wrigley%2C+Alice+P%3BStokes%2C+C+Shannon&rft.aulast=Wrigley&rft.aufirst=Alice&rft.date=1977-10-01&rft.volume=8&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Family+Studies&rft.issn=00472328&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCFSAO N1 - SubjectsTermNotLitGenreText - Sex role/Sex roles; Ideology/Ideologies/Ideological; Female/Females (see also Woman); High school/High schools; Student/Students ER - TY - JOUR T1 - Acoustical Characteristics of Infant Cries: Fundamental Frequency AN - 58079522; 7803095 AB - The fundamental fs (F0) of infant cries (Ss included 4 Ms & 4 Fs) were analyzed to determine if: (1) mean cry F0 differed as a function of the infant sex, & (2) mean cry F0 differed due to the stimulus evoking the cry. The results of this study indicate that there are no significant differences in mean cry F0 as a function of infant's sex or cry-evoking stimulus. However, there was a tendency for M infants to have higher mean F0 than Fs. The infants' F0 may confuse listeners attempting to make perceptual judgments about the cry's source & nature. Modified HA JF - Journal of Child Language AU - Murry, Thomas AU - Amundson, Pamela AU - Hollien, Harry AD - Veterans Administration Hospital, San Diego CA 92129 Y1 - 1977/10// PY - 1977 DA - October 1977 SP - 321 EP - 328 VL - 4 IS - 3 SN - 0305-0009, 0305-0009 KW - fundamental frequency of infant cries KW - sex differences KW - Sexual Differences (se15) KW - Infant Vocalization (in3) KW - Phonetics (ph9) KW - Fundamental Frequency (fu2) KW - article KW - 6110: phonetics; phonetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58079522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Language&rft.atitle=Acoustical+Characteristics+of+Infant+Cries%3A+Fundamental+Frequency&rft.au=Murry%2C+Thomas%3BAmundson%2C+Pamela%3BHollien%2C+Harry&rft.aulast=Murry&rft.aufirst=Thomas&rft.date=1977-10-01&rft.volume=4&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Language&rft.issn=03050009&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLGBJ N1 - SubjectsTermNotLitGenreText - Phonetics (ph9); Infant Vocalization (in3); Fundamental Frequency (fu2); Sexual Differences (se15) ER - TY - JOUR T1 - Linguistic Style and Personality AN - 58068315; 7902882 AB - Lang is a complex creative behavior; nevertheless, speakers may use language in characteristic ways related to their overall nonlinguistic behavioral style. Many different linguistic measures are necessary to methodologically approximate the enormous diversity of linguistic behavior. Forty-nine different linguistic variables used by 27 Ss were measured during a short speech segment. Multivariate statistical procedures were used to search the linguistic measures for evidence of linguistic traits & relate scores to four measures of nonlinguistic personality traits. The Dynamic Personality Inventory & employment status measured nonlinguistic behavioral style. Twenty-six of the forty-nine linguistic scores showed strong covariation (factor loadings of .70 or above) & loaded with other linguistic measures on nine factors. Findings suggest the Ss had linguistic traits. Linguistic factor scores accounted for 47% to 69% of the variance of three nonlinguistic scores & employment status. Each linguistic traits profile was distinctive; psychological interpretations of the traits correctly described behavioral characteristics of the associated personality type. Results show that linguistic styles are strongly related to overall personality & portray some personality aspect. How people use lang is a personality characteristic just as bodily postures, motor movement, & other stylistic behaviors. 3 Tables. AA JF - Language and Style AU - Hogben, George L AD - Veterans Administration Hospital, 130 West Kingsbridge Rd Bronx NY 10468 Y1 - 1977/10// PY - 1977 DA - October 1977 SP - 270 EP - 284 VL - 10 IS - 4 SN - 0023-8317, 0023-8317 KW - linguistic style KW - nonlinguistic personality traits, employment status KW - Dynamic Personality Inventory KW - Personality and Personality Investigation (pe7) KW - Applied Linguistics (ap2) KW - Behavioristic Linguistic Theory (be2) KW - article KW - 6710: linguistics and psychiatry; linguistics and psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language+and+Style&rft.atitle=Linguistic+Style+and+Personality&rft.au=Hogben%2C+George+L&rft.aulast=Hogben&rft.aufirst=George&rft.date=1977-10-01&rft.volume=10&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Language+and+Style&rft.issn=00238317&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LGNSAC N1 - SubjectsTermNotLitGenreText - Personality and Personality Investigation (pe7); Applied Linguistics (ap2); Behavioristic Linguistic Theory (be2) ER - TY - JOUR T1 - Environmental Resources and the Posttreatment Functioning of Alcoholic Patients AN - 60802706; 78J4301 AB - The posttreatment functioning of 429 alcoholic patients from 5 residential alcoholism programs was assessed in relation to: (1) the presence or absence of marital & occupational resources, & (2) if present, the type of social environment they provided. Patients in stable marital &/or work situations at admission had significantly better outcomes (drinking, psychological, social) than patients without those resources. Among the married patients, a more positive family milieu was associated with relatively greater improvement in the functioning of the alcoholic member. Among working patients, a more positively perceived work environment was associated with more successful posttreatment performance, but only among patients lacking marital support; for patients living with their spouses, no relationship was found. The results underscore the importance of including environmental measures, in addition to patient background characteristics, in longitudinal & evaluation research. 5 Tables. Modified HA. JF - Journal of Health and Social Behavior AU - Bromet, Evelyn AU - Moos, Rudolf H AD - Stanford U Medical Center, CA 94305 & Veterans Administration Hospital, Palo Alto CA 94301 Y1 - 1977/09// PY - 1977 DA - September 1977 SP - 326 EP - 338 VL - 18 IS - 3 SN - 0022-1465, 0022-1465 KW - alcoholic patients, posttreatment functioning, environmental resources impact KW - marital, occupational status, situational stability, family milieu, longitudinal, evaluation research KW - Alcohol KW - Patient/Patients KW - Health/Healthy KW - Resource/Resources KW - Family/Families KW - Alcoholic/Alcoholics/Alcoholism KW - Environment/Environments/ Environmental/ Environmentally KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60802706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+and+Social+Behavior&rft.atitle=Environmental+Resources+and+the+Posttreatment+Functioning+of+Alcoholic+Patients&rft.au=Bromet%2C+Evelyn%3BMoos%2C+Rudolf+H&rft.aulast=Bromet&rft.aufirst=Evelyn&rft.date=1977-09-01&rft.volume=18&rft.issue=3&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+and+Social+Behavior&rft.issn=00221465&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JHSBA5 N1 - SubjectsTermNotLitGenreText - Alcohol; Alcoholic/Alcoholics/Alcoholism; Patient/Patients; Health/Healthy; Family/Families; Resource/Resources; Environment/Environments/ Environmental/ Environmentally ER - TY - JOUR T1 - Religiosity and Self-Destructive Crises in the Institutionalized Elderly AN - 60805943; 79J7711 AB - The relationship of religiosity to self-destructive behavior has largely been considered in terms of the impact of religious affiliation & church membership on suicide rates for various geographical populations. Focus here is on the relationship between intensity of religious commitment & the use of indirect life-threatening behavior (ILTB), such as not following doctor's orders, smoking, & exposing one's self to a draft. Rating scaes to measure the occurrence of ILTB & religious commitment, respectively, were developed & administered to a sample of 58 long-term patients in a Veteran's Aministration hospital. Findings indicate that intensity of religious commitment is a potentially more meaningful measure of religiosity than formal church membership, that this intensity tends to vary inversely with the extent of ILTB observed for the patient, & that "stigma avoidance" may play a role in the tendency for certain religious affiliates to make more extensive use of ILTB. 1 Figure, 1 Table. Modified HA. JF - Suicide and Life-Threatening Behavior AU - Nelson, Franklyn L AD - Veterans Administration Wadsworth Hospital Center, Los Angeles CA 90021 Y1 - 1977/07// PY - 1977 DA - July 1977 SP - 67 EP - 74 VL - 7 IS - 2 SN - 0363-0234, 0363-0234 KW - institutionalized elderly, religiosity, self-destructive behavior KW - suicide rates, indirect life-threatening behavior, religious commitment vs church affiliation KW - Destruction KW - Behavior/Behavioral KW - Elder/Elders/Elderly KW - Religiosity KW - Self KW - Religion/Religions/Religious KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60805943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Religiosity+and+Self-Destructive+Crises+in+the+Institutionalized+Elderly&rft.au=Nelson%2C+Franklyn+L&rft.aulast=Nelson&rft.aufirst=Franklyn&rft.date=1977-07-01&rft.volume=7&rft.issue=2&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Self; Destruction; Behavior/Behavioral; Religion/Religions/Religious; Elder/Elders/Elderly; Religiosity ER - TY - JOUR T1 - The Alcoholic's Perception of the Ward as a Predictor of Aftercare Attendance AN - 60676265; 80K9652 AB - To determine whether attendance in aftercare services could be predicted from the alcoholic's perception of the inpatient ward environment, 35 subjects who had completed inpatient treatment & were eligible for outpatient group therapy were followed up 3 months after discharge. Subjects were selected from 8-week substance abuse programs administered between Aug 1974 & July 1975. One week into the program, subjects completed the Moos Ward Atmosphere Scale (Moos, R., Ward Atmosphere Scale Manual, Palo Alto: Consulting Psychologists Press, 1974) to measure 12 specific aspects of ward environment: (1) spontaneity, (2) support, (3) practicality, (4) affiliation, (5) order, (6) insight, (7) involvement, (8) aggression, (9) variety, (10) clarity, (11) submission, & (12) autonomy. Of these factors, perception of greater autonomy significantly differentiated attenders (number of cases = 13) from nonattenders (number of cases = 22). Although not to a statistically significant degree, the factors of aggression & insight also differentiated the groups. Attenders perceived more encouragement by staff to express angry feelings & share personal feelings with others than did nonattenders. 1 Table. Modified HA. JF - Journal of Clinical Psychology AU - Pratt, Theodore C AU - Linn, Margaret W AU - Carmichael, Joan S AU - Webb, NancyL AD - Veterans Administration Hospital, Miami FL 33187 Y1 - 1977/07// PY - 1977 DA - July 1977 SP - 915 EP - 918 VL - 33 IS - 3 SN - 0021-9762, 0021-9762 KW - alcoholics' inpatient ward perceptions as aftercare attendance predictor KW - Moos Ward Atmosphere Scale KW - Veteran's Administration Hospital, Miami/Florida KW - Perspective/Perspectives KW - After-care KW - Ward KW - Alcoholic/Alcoholics/Alcoholism KW - Attendance KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60676265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=The+Alcoholic%27s+Perception+of+the+Ward+as+a+Predictor+of+Aftercare+Attendance&rft.au=Pratt%2C+Theodore+C%3BLinn%2C+Margaret+W%3BCarmichael%2C+Joan+S%3BWebb%2C+NancyL&rft.aulast=Pratt&rft.aufirst=Theodore&rft.date=1977-07-01&rft.volume=33&rft.issue=3&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Alcoholic/Alcoholics/Alcoholism; Ward; Perspective/Perspectives; After-care; Attendance ER - TY - JOUR T1 - Effect on Hearing Thresholds of Surgical Modification of the External Ear AN - 58091158; 7901276 AB - External ear anatomy modifications following tympanomastoid surgery can have significant effects on hearing threshold. Experiments are described demonstrating the acoustic effect of changes in concha & ear canal dimensions on external ear sound pressure gain. An attempt is made to correlate these findings with results in thirty posttympanomastoidectomy ears & develop basic principles of external ear surgery that might be clinically useful. 12 Figures. HA JF - Annals of Otology, Rhinology & Laryngology AU - Goode, Richard L AU - Friedrichs, Robert AU - Falk, Stephen AD - Stanford U Medical Center, CA 94305 & Palo Alto Veterans Administration Hospital, CA 94305 Y1 - 1977/07// PY - 1977 DA - July 1977 SP - 441 EP - 450 VL - 86 IS - 4 SN - 0003-4894, 0003-4894 KW - hearing threshold effects of surgical external ear modification KW - Mastoidectomy (ma5) KW - Outer Ear, Pinna, Auricle (ou1) KW - Auditory Thresholds (au8) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58091158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Otology%2C+Rhinology+%26+Laryngology&rft.atitle=Effect+on+Hearing+Thresholds+of+Surgical+Modification+of+the+External+Ear&rft.au=Goode%2C+Richard+L%3BFriedrichs%2C+Robert%3BFalk%2C+Stephen&rft.aulast=Goode&rft.aufirst=Richard&rft.date=1977-07-01&rft.volume=86&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Annals+of+Otology%2C+Rhinology+%26+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AORHA2 N1 - SubjectsTermNotLitGenreText - Auditory Thresholds (au8); Outer Ear, Pinna, Auricle (ou1); Mastoidectomy (ma5) ER - TY - JOUR T1 - Medial and anterior-posterior ligament stability of the human knee, measured with a stress apparatus AN - 20076239; 10092094 JF - American Journal of Sports Medicine AU - Mains, Douglas B AU - Andrews, James G AU - Stonecipher, Thomas AD - Hines Veterans Administration Hospital, Hines, Illinois, the Loyola University Stritch School of Medicine, Maywood, Illinois, and the University of Iowa, Iowa City, Iowa Y1 - 1977/07// PY - 1977 DA - Jul 1977 SP - 144 EP - 153 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 5 IS - 4 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Measurement KW - Ligaments KW - Equipment KW - Knees KW - Stress KW - Sports medicine KW - Stability KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20076239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Medial+and+anterior-posterior+ligament+stability+of+the+human+knee%2C+measured+with+a+stress+apparatus&rft.au=Mains%2C+Douglas+B%3BAndrews%2C+James+G%3BStonecipher%2C+Thomas&rft.aulast=Mains&rft.aufirst=Douglas&rft.date=1977-07-01&rft.volume=5&rft.issue=4&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354657700500402 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Measurement; Ligaments; Equipment; Knees; Stress; Stability; Sports medicine DO - http://dx.doi.org/10.1177/036354657700500402 ER - TY - JOUR T1 - Erikson's Theory of Psychosocial Development and Career Development AN - 60812437; 79J9711 AB - The theory of psychological development proposed by E. H. Erickson (Childhood and Society, New York: Norton, 1963) can be applied to the formulation of a developmental perspective on career choice. This theory considers human life as marked by a series of decisive turning points requiring resolution. The concept of the identity crisis is particularly significant for career choice. Review of vocational literature suggests that Erikson's theory may be applicable to a variety of problems in this field. W. H. Stoddard. JF - Journal of Vocational Behavior AU - Munley, Patrick H AD - Veterans Administration Hospital, Lyons NJ 07939 Y1 - 1977/06// PY - 1977 DA - June 1977 SP - 261 EP - 269 VL - 10 IS - 3 SN - 0001-8791, 0001-8791 KW - E. H. Erickson's psychosocial development, career choices KW - decisive turning points in human lives, identity crisis, Childhood and Society KW - Development/Developments KW - Change/Changes KW - Identity/Identities KW - Human/Humans/Humanity KW - Erikson, Erik H. KW - Choice/Choices KW - Psychology/Psychological/ Psychologically/ Psychologism KW - Career/Careers KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60812437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vocational+Behavior&rft.atitle=Erikson%27s+Theory+of+Psychosocial+Development+and+Career+Development&rft.au=Munley%2C+Patrick+H&rft.aulast=Munley&rft.aufirst=Patrick&rft.date=1977-06-01&rft.volume=10&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vocational+Behavior&rft.issn=00018791&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JVBHA2 N1 - SubjectsTermNotLitGenreText - Erikson, Erik H.; Psychology/Psychological/ Psychologically/ Psychologism; Development/Developments; Career/Careers; Choice/Choices; Change/Changes; Human/Humans/Humanity; Identity/Identities ER - TY - JOUR T1 - A Methodological Study of Sex Stereotypes AN - 60067161; 79J6877 AB - This methodological investigation of sex stereotypes employed three different instruments to collect sex stereotypes from 264 undergraduate students at a midwestern U, 50% M, 50% F. The Adjective Check List & the Stereotype Questionnaire elicited different stereotypes, while an open-ended form elicited no stereotypic items. It was hypothesized that Ss would describe adult Ms & Fs differently, & that visual imagery of particular persons would be involved in the response process of the Ss. The first phase found that Ss reported visual imagery of particular persons while responding. In a second phase, the stereotypic items obtained in the collection phase were marked on the appropriate instrument form for a M & F description. These forms with a set of multiple choice questions, concerning such things as sex of the description, desirability, adjustment, & of the Ss' experience of visual imagery, were given to 180 additional psychology students. The stereotypic items were found to convey reliable information as to judgment of the sex of the stimulus stereotypic items; however, the different instruments conveyed differential information as to sex of stimulus items, desirability, & adjustment of the instrument description. Visual imagery of Ss was found to be significantly related to correct judgment of sex of stimulus items & to high confidence in that judgment. Two factors operating in the response process include the Ss' stereotypic patterning & the structural possibilities of the instrument's response modality. The pronoun "he" generates a distinct M image, ie, both men & women visually imagine M persons & respond with descriptions that are partially stereotypic. 5 Tables. Modified HA. JF - Sex Roles AU - Cowan, Margie L AU - Stewart, Barbara J AD - Veterans Administration Center, Wichita KS 67218 & Oklahoma State U, Stillwater 74074 Y1 - 1977/06// PY - 1977 DA - June 1977 SP - 205 EP - 216 VL - 3 IS - 3 SN - 0360-0025, 0360-0025 KW - sex stereotypes, methodological study KW - Adjective Check List, Stereotype Questionnaire, open-ended form, differential information KW - Methodology/Methodologies/ Methodological (see also Method) KW - Stereotype/Stereotypes/ Stereotyped/ Stereotyping KW - Sex role/Sex roles KW - Sex differences (see also Gender differences) KW - Social research KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60067161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sex+Roles&rft.atitle=A+Methodological+Study+of+Sex+Stereotypes&rft.au=Cowan%2C+Margie+L%3BStewart%2C+Barbara+J&rft.aulast=Cowan&rft.aufirst=Margie&rft.date=1977-06-01&rft.volume=3&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Sex+Roles&rft.issn=03600025&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - SROLDH N1 - SubjectsTermNotLitGenreText - Sex role/Sex roles; Stereotype/Stereotypes/ Stereotyped/ Stereotyping; Methodology/Methodologies/ Methodological (see also Method); Social research; Sex differences (see also Gender differences) ER - TY - JOUR T1 - Language Therapy Effects in Long Term Aphasia AN - 58104580; 8201846 AB - Described are the results of language therapy initiated 1 to 6 years after the onset of aphasia in 14 M patients aged 43 to 79 years. During the course of treatment all Ss improved strongly in communicative abilities as measured by the Porch Index of Communicative Abilities. Clinical observations & reports from family members & hospital ward personnel were also positive. 5 Tables. HA JF - Archives of Physical Medicine and Rehabilitation AU - Broida, Helen AD - Veterans Administration Hospital, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1977/06// PY - 1977 DA - June 1977 SP - 248 EP - 253 VL - 58 IS - 6 SN - 0003-9993, 0003-9993 KW - language therapy program, aphasics, six years post-onset KW - description/results KW - Porch Index of Communicative Abilities KW - Language Therapy (la7a) KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58104580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Language+Therapy+Effects+in+Long+Term+Aphasia&rft.au=Broida%2C+Helen&rft.aulast=Broida&rft.aufirst=Helen&rft.date=1977-06-01&rft.volume=58&rft.issue=6&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHAI N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Pathology (la4); Language Therapy (la7a) ER - TY - JOUR T1 - Hearing Aids & Hearing Deterioration AN - 85432595; 7901265 AB - The literature contains conflicting reports as to whether hearing deterioration is increased by the use of hearing aids. A study of 261 patients over a ten-year period shows that there is no hearing loss increase in the aided ear which can be attributed to the use of a hearing aid. 7 Tables. HA JF - Annals of Otology, Rhinology & Laryngology AU - Titche, Leon L AU - Windrem, Emory O AU - Starmer, William T AD - Veterans Administration Hospital, Tucson AZ 85723 Y1 - 1977/05// PY - 1977 DA - May 1977 SP - 357 EP - 361 VL - 86 IS - 3 SN - 0003-4894, 0003-4894 KW - hearing aids, hearing deterioration KW - Hearing Disorders (he3a) KW - Hearing Conservation and Improvement (he2) KW - Hearing Aids (he1) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85432595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Otology%2C+Rhinology+%26+Laryngology&rft.atitle=Hearing+Aids+%26amp%3B+Hearing+Deterioration&rft.au=Titche%2C+Leon+L%3BWindrem%2C+Emory+O%3BStarmer%2C+William+T&rft.aulast=Titche&rft.aufirst=Leon&rft.date=1977-05-01&rft.volume=86&rft.issue=3&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Annals+of+Otology%2C+Rhinology+%26+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AORHA2 N1 - SubjectsTermNotLitGenreText - Hearing Aids (he1); Hearing Conservation and Improvement (he2); Hearing Disorders (he3a) ER - TY - JOUR T1 - Extended Comprehension Practice Applied to an Aphasic Patient AN - 58068347; 7902920 AB - A forty-seven-year-old aphasic patient was given extensive practice in comprehending single lexical items. Training was begun one month postonset & ended four months postonset. No production practice was administered during the training period. Comprehension practice used simple drawings representing common Ns, introduced in order of increasing complexity. The patient was instructed to point to the correct picture after the clinician had said its name. Comprehension & reproduction both improved as measured by several language assessment tests. Findings suggest that comprehension practice results in verbal production improvement. Auditory comprehension is viewed as "the primary avenue through which linguistic structures are facilitated or relearned." Because the patient is not required to verbalize, it is emphasized that comprehension should be acquired before production. 4 Figures, 1 Table. Modified HA JF - Journal of Speech and Hearing Disorders AU - Kushner, Deanie AU - Winitz, Harris AD - Veterans Administration Hospital, 4801 Linwood Kansas City MO 64128 & U Missouri, Kansas City 64110 Y1 - 1977/05// PY - 1977 DA - May 1977 SP - 296 EP - 305 VL - 42 IS - 2 KW - comprehension practice, language therapy KW - 47-year-old aphasic KW - Listening Comprehension (li4) KW - Language Therapy (la7a) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Extended+Comprehension+Practice+Applied+to+an+Aphasic+Patient&rft.au=Kushner%2C+Deanie%3BWinitz%2C+Harris&rft.aulast=Kushner&rft.aufirst=Deanie&rft.date=1977-05-01&rft.volume=42&rft.issue=2&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Therapy (la7a); Listening Comprehension (li4) ER - TY - JOUR T1 - Schizophrenic Cognitive Dysfunction: A Deficit in Rule Transfer AN - 85441692; 8004674 AB - Examined was the conceptual rule learning (RL) deficit in M schizophrenics (N = 36) categorized into three groups as defined by the Whitaker Index of Schizophrenic Thinking (WIST). Ss were given a conjunctive, disjunctive, conditional, or biconditional rule learning task, the WIST, & the Shipley-Hartford Memory Scale. Results indicated that: (1) the WIST reliably differentiated between three levels of thought disorder as reflected in a deficit in inner-problem transfer of rule learning, (2) certain WIST & Shipley parameters reliably predicted RL performance, & (3) phenothiazine dosage levels showed no influence on the WIST & no r with RL. Findings indicate that cognitive dysfunction in schizophrenics is evidenced by limited inductive reasoning, insufficient channel capacity for filtering out irrelevant information, & inability to gain from previous RL experience. The principal locus of schizophrenic thought disorder is discussed within a stimulus encoding-information processing framework. 2 Table, 2 Figures. Modified HA JF - Journal of Clinical Psychology AU - Pishkin, Vladimir AU - Lovallo, William R AU - Lenk, Robert G AU - Bourne, Lyle E, Jr AD - Veterans Administration Hospital, Oklahoma City OK 73104 Y1 - 1977/04// PY - 1977 DA - April 1977 SP - 335 EP - 342 VL - 33 IS - 2 SN - 0021-9762, 0021-9762 KW - schizophrenic cognitive dysfunction KW - conceptual rule learning KW - Whitaker Index of Schizophrenic Thinking, Shipley-Hartford Memory Scale, rule learning task KW - male schizophrenics KW - Schizophrenia (sc1) KW - Cognitive Processes (co1b) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Schizophrenic+Cognitive+Dysfunction%3A+A+Deficit+in+Rule+Transfer&rft.au=Pishkin%2C+Vladimir%3BLovallo%2C+William+R%3BLenk%2C+Robert+G%3BBourne%2C+Lyle+E%2C+Jr&rft.aulast=Pishkin&rft.aufirst=Vladimir&rft.date=1977-04-01&rft.volume=33&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Cognitive Processes (co1b); Schizophrenia (sc1) ER - TY - JOUR T1 - Interviewing Changes Attitudes--Sometimes AN - 60858439; 78J1542 AB - Whether asking questions about a subject can change attitudes on that subject is important for a variety of survey methods, especially panel studies where Rs are asked the same question on successive occasions. A sample of 414 (out of total 616) staff personnel at UCLA were successfully interviewed (yielding 376 usable responses). Of the total, 50% were interviewed on burglary prevention, & reinterviewed five weeks later concerning both cancer & burglary--50% having been furnished information about crime prevention in the interim. Asking questions about cancer changed attitudes toward cancer, but asking questions about burglary did not change attitudes toward crime. Rs who had received information about crime rated it more important than those who had not. Interview effects, possibly due to competence motivation & a desire to preserve self-esteem in the interview situation, will occur when the R's attitudes & information are unfocused or ambiguous & the topic is important. 1 Table. Modified HA. JF - The Public Opinion Quarterly AU - Bridge, R Gary AU - Reeder, Leo G AU - Kanouse, David AU - Kinder, Donald R AU - Nagy, Vivian Tong AU - Judd, Charles, M. AD - Columbia U, New York NY 10027, U California, Los Angeles 90024, Yale U, New Haven CT 06520, Veterans Administration, Los Angeles, CA & Harvard U, Cambridge MA 03128 Y1 - 1977/04// PY - 1977 DA - April 1977 SP - 56 EP - 64 VL - 41 IS - 1 SN - 0033-362X, 0033-362X KW - interview's impact, respondents' attitudes change KW - panel studies, crime, cancer surveys, differential results, self-esteem preservation, competence motivation KW - Attitude/Attitudes/Attitudinal KW - Response/Responsive/ Responsiveness/Responses KW - Interview/Interviews/Interviewing KW - Survey/Surveys KW - Social research KW - article KW - 0103: methodology and research technology; methodology (conceptual & epistemological) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60858439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Public+Opinion+Quarterly&rft.atitle=Interviewing+Changes+Attitudes--Sometimes&rft.au=Bridge%2C+R+Gary%3BReeder%2C+Leo+G%3BKanouse%2C+David%3BKinder%2C+Donald+R%3BNagy%2C+Vivian+Tong%3BJudd%2C+Charles%2C+M.&rft.aulast=Bridge&rft.aufirst=R&rft.date=1977-04-01&rft.volume=41&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+Public+Opinion+Quarterly&rft.issn=0033362X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - POPQAE N1 - SubjectsTermNotLitGenreText - Survey/Surveys; Interview/Interviews/Interviewing; Attitude/Attitudes/Attitudinal; Social research; Response/Responsive/ Responsiveness/Responses ER - TY - JOUR T1 - Death and Dying in Modern America AN - 60804315; 78J5633 AB - To fully understand ourselves as humans, we must examine the talent that distinguishes us from all other species--our ability to conceptualize a future & inevitable death. Death has become uncomfortable to deal with because we no longer command philosophic or religious conceptual creeds with which to transcend death. Additionally, increasing fragmentation of the modern family, deritualization of grief, the expulsion of death from common, daily experience, & worship of youth, productivity, & achievement are influential factors. Systematic findings now suggest that death is for all seasons. Its steering influence is evidence in the young as well as old, healthy as well as sick. A fact of import is that attitudes toward death are complex & far from homogeneous. In the face of death, the human mind seemingly operates simultaneously on various levels of reality or finite provinces of meaning, each of which can be somewhat autonomous. The time is ripe for "death education" to assume a proper role in our cultural upbringing as a preparation for living. The transition in expectations about life & death along with new alternatives available as a result of medical expertise now mean that we must take into account systems other than the biological & psychological in treating dying persons. Adequate concern for the seriously ill & dying requires reassessment of existing social organizations & public policy responsible for health care & delivery. In responding to finiteness, it will be easier to define values, priorities, & life goals, & move toward a more common sharing of our humanity--all too eroded in the present world. AA. JF - Death Education AU - Feifel, Herman AD - Veterans Administration Outpatient Clinic, Los Angeles CA Y1 - 1977/04// PY - 1977 DA - April 1977 SP - 5 EP - 14 VL - 1 IS - 1 KW - US, death perceptions KW - transcendent creeds loss, grief deritualization, education need, expectations transition process KW - Death/Deaths (see also Mortality, Dying) KW - Existence KW - Philosophy/Philosophies/ Philosophical KW - United States/US KW - Value/Values/Valuation/ Valuations KW - Grief KW - Education/Educational/Educator/ Educators/ Educationally KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60804315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Death+Education&rft.atitle=Death+and+Dying+in+Modern+America&rft.au=Feifel%2C+Herman&rft.aulast=Feifel&rft.aufirst=Herman&rft.date=1977-04-01&rft.volume=1&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Death+Education&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Death/Deaths (see also Mortality, Dying); United States/US; Philosophy/Philosophies/ Philosophical; Grief; Existence; Education/Educational/Educator/ Educators/ Educationally; Value/Values/Valuation/ Valuations ER - TY - JOUR T1 - Base-10 Programmed Stimulation: Task Specification, Scoring, and Plotting Performance in Aphasia Therapy AN - 85500342; 7902921 AB - Applicability of time-series designs to document therapy effects with aphasic Ss is explained & advocated. A measurement system contributing to therapy organization, task specification & scoring, & graphic display of speech & language changes is described. Application of the Base-10 Programmed Stimulation with specific Ss is illustrated. Speech & language tasks make up ten stimulus items scored & plotted during ten therapy sessions on a special form. The form allows space for several exact specifications concerning the task, & allows performance levels to be converted to a graphic display. The system's application can help confirm the impression that "therapy has a significant & positive effect on language recovery beyond that which can be expected by spontaneous recovery." 8 Figures. Modified HA JF - Journal of Speech and Hearing Disorders AU - LaPointe, Leonard L AD - Veterans Administration Hospital, 1601 Archer Rd Gainesville FL 32602 Y1 - 1977/02// PY - 1977 DA - February 1977 SP - 90 EP - 105 VL - 42 IS - 1 KW - aphasia therapy KW - Base-10 Programmed Stimulation KW - task specification, scoring, plotting performance KW - Language Therapy (la7a) KW - Data Processing and Retrieval (da1) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85500342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Base-10+Programmed+Stimulation%3A+Task+Specification%2C+Scoring%2C+and+Plotting+Performance+in+Aphasia+Therapy&rft.au=LaPointe%2C+Leonard+L&rft.aulast=LaPointe&rft.aufirst=Leonard&rft.date=1977-02-01&rft.volume=42&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Language Therapy (la7a); Data Processing and Retrieval (da1) ER - TY - JOUR T1 - Nonverbal Assessment of Interpersonal Affect AN - 85443672; 8005792 AB - Two nonverbal methods for assessing interpersonal attraction degree were explored. Ss aged 11 to 13 years (N = 20) were asked to select two liked & two disliked same-sex classmates. On 4 trials, Ss selected a geometric block to represent themselves & one to represent a preselected classmate & placed them on a ruled board. Distance between blocks was found significantly related to peer liking. Ss were also asked to draw each of the four peers. Drawings were rated for total pictorial detail (found to vary strongly across liking magnitude for F Ss) & for parts integration (found to vary with peer liking degree for both sexes). Drawings' degree of rated positive affective tone also increased with liking. Implications of these instruments for clinical practice are discussed. 1 Table. Modified HA JF - Journal of Personality Assessment AU - Gilbert, Gary S AU - Kirkland, Karen D AU - Rappoport, Leon AD - Veterans Administration Hospital, 800 Stadium Rd Columbia MO 65201 Y1 - 1977/02// PY - 1977 DA - February 1977 SP - 43 EP - 48 VL - 41 IS - 1 SN - 0022-3891, 0022-3891 KW - interpersonal attraction assessment KW - nonverbal method KW - geometric block selection, drawing KW - same sex classmates aged 11 to 13 years KW - Interpersonal Behavior (in15) KW - Nonverbal Communication (no4a) KW - article KW - 5810: nonverbal communication; human nonverbal language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85443672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Nonverbal+Assessment+of+Interpersonal+Affect&rft.au=Gilbert%2C+Gary+S%3BKirkland%2C+Karen+D%3BRappoport%2C+Leon&rft.aulast=Gilbert&rft.aufirst=Gary&rft.date=1977-02-01&rft.volume=41&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Nonverbal Communication (no4a); Interpersonal Behavior (in15) ER - TY - JOUR T1 - Speech Compression: Personality Correlates of Successful Use AN - 58074004; 7903740 AB - Blinded veterans (N = 129) were asked to listen to four sections of a seventh-grade level biographical sketch recorded at progressively faster rates (1.0, 1.5, 2.0, & 2.5 times the initial rate of 194 words per minute) through an electronic discrete time compressed speech device. After each section, multiple choice questions were asked. Variables, eg, age, hearing aid use, educational level, Weschler Adult Intelligence Scale Verbal IQ, & scale scores of the Minnesota Multiphasic Personality Inventory & the California Psychological Inventory were analyzed for possible relationships with the S's maximum comprehended compression rate. Younger veterans whose personality tests indicated better psychological adjustment tended to be more successful in comprehending compressed speech. 2 Tables, 1 Figure. Modified HA JF - Journal of Visual Impairment and Blindness AU - De L'Aune, W AU - Lewis, C AU - Needham, W AU - Nelson, J AD - Veterans Administration Hospital, West Haven CT 06516 Y1 - 1977/02// PY - 1977 DA - February 1977 SP - 66 EP - 68 VL - 71 IS - 2 SN - 0145-482X, 0145-482X KW - compressed speech comprehension KW - IQ, personality, education, hearing aid use, age KW - Weschler Adult Intelligence Scale, Minnesota Multiphasic Personality Inventory, California Psychological Inventory KW - blinded veterans KW - Speech Rate (sp7) KW - Intelligence Testing (in9) KW - Hearing Aids (he1) KW - Personality and Personality Investigation (pe7) KW - Vision Disorders (vi1) KW - Age Differences in Language (ag1) KW - article KW - 4610: discourse analysis/text linguistics; discourse analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58074004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visual+Impairment+and+Blindness&rft.atitle=Speech+Compression%3A+Personality+Correlates+of+Successful+Use&rft.au=De+L%27Aune%2C+W%3BLewis%2C+C%3BNeedham%2C+W%3BNelson%2C+J&rft.aulast=De+L%27Aune&rft.aufirst=W&rft.date=1977-02-01&rft.volume=71&rft.issue=2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visual+Impairment+and+Blindness&rft.issn=0145482X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JVIBDM N1 - SubjectsTermNotLitGenreText - Personality and Personality Investigation (pe7); Speech Rate (sp7); Hearing Aids (he1); Intelligence Testing (in9); Age Differences in Language (ag1); Vision Disorders (vi1) ER - TY - JOUR T1 - Right-Hemisphere Language Dominance in a Case of Left-Hemisphere Arteriovenous Malformation AN - 58068080; 7902876 AB - A case of surgical removal of a left-hemisphere arteriovenous malformation (AVM) in a left-handed adult without subsequent speech or lang deficit is reported. Preoperative intracarotid amobarbitol testing indicated right-hemisphere language dominance. The patient showed no lang involvement, either pre- or postsurgery. It was hypothesized that the congenital nature of a left-hemisphere AVM may dictate development of right-hemisphere language & that this congenital defect could also play a role in developing left-handedness. This would explain the lack of residual effect on removal of the left-hemisphere speech & motor area. 2 Figures, 1 Table. Modified HA JF - Journal of Speech and Hearing Disorders AU - Wertz, Robert T AU - Messert, Bernard AU - Collins, Michael AU - Rosenbek, Jay C AU - Kao, Chun C AD - Veterans Administration Hospital, 2500 Overlook Terrace Madison WI 53705 & U Wisconsin, Madison 53706 Y1 - 1977/02// PY - 1977 DA - February 1977 SP - 106 EP - 112 VL - 42 IS - 1 KW - right-hemisphere language dominance in left-hemisphere arteriovenous malformation case KW - left-handed adult KW - case study KW - Handedness (ha2) KW - Cerebral Dominance (ce2) KW - Language Pathology (la4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Right-Hemisphere+Language+Dominance+in+a+Case+of+Left-Hemisphere+Arteriovenous+Malformation&rft.au=Wertz%2C+Robert+T%3BMessert%2C+Bernard%3BCollins%2C+Michael%3BRosenbek%2C+Jay+C%3BKao%2C+Chun+C&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=1977-02-01&rft.volume=42&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Cerebral Dominance (ce2); Handedness (ha2) ER - TY - JOUR T1 - Differences in Word Association Commonality of Schizophrenics: The Self-Editing-Deficit Model vs. the Partial-Collapse-of-Response-Hierarchy Hypothesis AN - 85435770; 8005980 AB - Schizophrenics matched by pairs with 26 neurotics were found not to differ in commonality scores under free association conditions on steep-slope words from a list equated for "idiodynamic set pull." Schizophrenics scored significantly lower in commonality on flat-slope words, where steep-slope & flat-slope refer to words with one or several commonly occurring associates, respectively. Schizophrenics (N = 23) matched with normal controls scored significantly lower in commonality on both steep-slope & flat-slope words. Findings are contrary to predictions derived from the two-stage self-editing-deficit model, & support the one-stage, partial-collapse-of-hierarchy model. Other results suggest that these models might be modified to take into account the idiodynamic set pull of stimulus words. 3 Tables. Modified HA JF - Journal of Clinical Psychology AU - Penk, W E AU - Kidd, R V AD - Veterans Administration Hospital, Dallas TX 75216 Y1 - 1977/01// PY - 1977 DA - January 1977 SP - 32 EP - 39 VL - 33 IS - 1 SN - 0021-9762, 0021-9762 KW - word association commonality, steep- vs flat-slope words KW - schizophrenic vs neurotic vs normal persons KW - Schizophrenia (sc1) KW - Free Association (fr1) KW - Neurotic Disorders (ne4) KW - Word and Letter Association (wo2) KW - article KW - 6710: linguistics and psychiatry; linguistics and psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85435770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Differences+in+Word+Association+Commonality+of+Schizophrenics%3A+The+Self-Editing-Deficit+Model+vs.+the+Partial-Collapse-of-Response-Hierarchy+Hypothesis&rft.au=Penk%2C+W+E%3BKidd%2C+R+V&rft.aulast=Penk&rft.aufirst=W&rft.date=1977-01-01&rft.volume=33&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Schizophrenia (sc1); Neurotic Disorders (ne4); Word and Letter Association (wo2); Free Association (fr1) ER - TY - JOUR T1 - The Intensive Care Unit: Social Work Intervention with the Families of Critically III Patients AN - 61576382; 197900412 AB - Hospital intensive care units can be a significant practice area for social workers. Nowhere are families in more obvious crises than when faced with the life-threatening illness of a significant other who may be unresponsive & dependent on a frightening array of highly technical equipment. Using the crisis model for their intervention, social workers can significantly lessen the trauma experienced by these families. Additionally, they can develop other supportive hospital resources such as family groups & volunteer services to help meet their needs. HA. JF - Social Work in Health Care AU - Williams, Cindy Cook AU - Rice, Donetta G AD - Veterans Administration Hospital, 4435 Beacon Ave S Seattle WA 98108 Y1 - 1977///0, PY - 1977 DA - 0, 1977 SP - 391 EP - 398 VL - 2 IS - 4 SN - 0098-1389, 0098-1389 KW - Crisis Intervention KW - Family KW - Social Work KW - Hospitals KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61576382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=The+Intensive+Care+Unit%3A+Social+Work+Intervention+with+the+Families+of+Critically+III+Patients&rft.au=Williams%2C+Cindy+Cook%3BRice%2C+Donetta+G&rft.aulast=Williams&rft.aufirst=Cindy&rft.date=1977-01-01&rft.volume=2&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work; Crisis Intervention; Hospitals; Family ER - TY - JOUR T1 - The Social Work Stake in Problem-Oriented Recording AN - 61554405; 198000141 AB - Pressure for adoption of Problem-Oriented Recording (POR) is coming from various sources outside the helping professions: (1) from commercial third-party payers who have a legitimate need to scrutinize claims for payment; (2) from all levels of government, out of concern for cost containment & for decisions regarding the allocation of limited resources; & (3) from consumers demanding quality assurance & accountability mechanisms. POR is an ecological approach that promotes the concept of comprehensive health care. As social work is concerned with both the person & his environment, with the causes & the sequelae of illness & the interrelationship of problems, this problem-oriented approach is of immense interest to the profession. The social worker in an ecologically oriented health care system immediately becomes a more significant provider of health care. Modified HA. JF - Social Work in Health Care AU - Biagi, Ettore AD - Veterans Administration Out Patient Clinic, 252 Seventh Ave New York NY 10001 Y1 - 1977/01// PY - 1977 DA - January 1977 SP - 211 EP - 221 VL - 3 IS - 2 SN - 0098-1389, 0098-1389 KW - social work, ecologically-oriented health care system, accountability/Problem-Oriented Recording KW - Social work KW - Responsibility/Responsibilities KW - Finance/Finances/Financial/ Financing KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61554405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=The+Social+Work+Stake+in+Problem-Oriented+Recording&rft.au=Biagi%2C+Ettore&rft.aulast=Biagi&rft.aufirst=Ettore&rft.date=1977-01-01&rft.volume=3&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social work; Finance/Finances/Financial/ Financing; Responsibility/Responsibilities ER - TY - JOUR T1 - Anhedonia as a Function of Non-Affective Interpretation of Ambiguous Stimuli and Threshold for Affective and Neutral Stimuli AN - 58082362; 8005981 AB - Tested was the theory that schizophrenic anhedonia - the failure to express pleasure - is associated with a tendency to interpret ambiguous stimuli as neutral rather than emotion-laden, & arises from selectively high perceptual thresholds for affective stimuli. Schizophrenic Ms (N = 76) were to guess whether words presented tachistoscopically were positive, negative, or neutral in content. High-anhedonic Ss were significantly more likely to guess neutral words, & less likely to offer pleasant interpretations than the low-anhedonic sample. Thresholds of the two groups were compared on pleasant, unpleasant, & neutral tachistoscopically presented stimuli (pictorial). High anhedonics showed greater thresholds for neutral stimuli than low anhedonics. Findings suggest that anhedonia is not mediated by high thresholds for affective stimuli. 3 Tables. Modified HA JF - Journal of Clinical Psychology AU - Watson, Charles G AD - Veterans Administration Hospital, Saint Cloud MN 56301 Y1 - 1977/01// PY - 1977 DA - January 1977 SP - 58 EP - 63 VL - 33 IS - 1 SN - 0021-9762, 0021-9762 KW - anhedonia KW - affective stimuli perceptual threshold, ambiguous stimuli nonaffective interpretation KW - schizophrenic males KW - Schizophrenia (sc1) KW - Ambiguity (am1) KW - Psychoanalysis and Psychotherapy (ps2) KW - article KW - 6710: linguistics and psychiatry; linguistics and psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58082362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychology&rft.atitle=Anhedonia+as+a+Function+of+Non-Affective+Interpretation+of+Ambiguous+Stimuli+and+Threshold+for+Affective+and+Neutral+Stimuli&rft.au=Watson%2C+Charles+G&rft.aulast=Watson&rft.aufirst=Charles&rft.date=1977-01-01&rft.volume=33&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPYAO N1 - SubjectsTermNotLitGenreText - Schizophrenia (sc1); Psychoanalysis and Psychotherapy (ps2); Ambiguity (am1) ER - TY - JOUR T1 - Drugs and Drug Metabolites as Environmental Contaminants: Chlorophenoxyisobutyrate and Salicylic Acid in Sewage Water Effluent AN - 19162692; 7707045 AB - Effluent of the Big Blue River Sewage Treatment Plant, Kansas City, Missouri, was analyzed to determine the content of drugs or drug metabolites. Composite 24-hour samples were collected and extracted under acidic, neutral, and basic conditions with methylene chloride. The extracts were screened by gas chromatography-mass spectrometry. Results indicated the presence of 2-(4-chlorophenoxy)-2-methylpropanoic acid (CPIB), the active metabolite of clofibrate, a hypolipidemic drug; and 2-hydroxy benzoic acid (salicylic acid), a metabolite of aspirin. Average 24-hour discharges of CPIB from August, 1975 to May, 1976 were 2.1 kilograms/day and salicylic acid discharges for the same period were 8.64 kilograms/day. Concentrations in raw sewage for CPIB were 2.8 kilograms/day. Raw sewage concentrations of salicylic acid were much higher and a 90% removal of this metabolite was shown from the data. Neither compound was detected in drinking water. Further investigations for drugs in water were suggested. (Collins-FIRL) JF - Life Sciences Vol. 20, No. 2, p 337-342, January, 1977. 1 fig, 1 tab, 9 ref. AU - Hignite, C AU - Azarnoff, D L AD - Veterans Administration Hospital Kansas City, Mo Y1 - 1977/01// PY - 1977 DA - Jan 1977 KW - Water Resources Abstracts KW - Water pollution sources KW - Chemical analysis KW - Analytical techniques KW - Pollutant identification KW - Waste identification KW - Sewage effluents KW - Potable water KW - Gas chromatography KW - Mass spectrometry KW - Waste water treatment KW - SW 3040:Wastewater treatment processes KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19162692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Drugs+and+Drug+Metabolites+as+Environmental+Contaminants%3A+Chlorophenoxyisobutyrate+and+Salicylic+Acid+in+Sewage+Water+Effluent&rft.au=Hignite%2C+C%3BAzarnoff%2C+D+L&rft.aulast=Hignite&rft.aufirst=C&rft.date=1977-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Assessment of Conceptual Deficits in Brain-Damaged and Schizophrenic Patients AN - 85433058; 7901307 AB - Five concept-formation scores for 20 brain-damaged & 20 schizophrenic Ss were factor analyzed, along with WAIS Vocabulary & Block Design. One factor emerged from this analysis, suggesting that these concept-formation tests do not measure an ability greatly different from general intelligence for Ss of the type studied. None of the single concept-formation scores discriminated between the brain-damaged & schizophrenic groups independently of general intellectual level, although an exploratory analysis of the subtests of the Halstead Category Test indicated that differential performance on Subtest IV vs Subtest V produced valid criterion variance beyond that attributable to Vocabulary & Block Design alone. Findings were discussed in terms both of the factors underlying the present Ss' performance vs that of different S populations, & of the need for refining ability-oriented diagnostic strategies when studying imparied Ss not manifesting highly specific psychological deficits on standard clinical tests yielding single scores. 1 Table. Modified HA JF - Perceptual and Motor Skills AU - Holland, Terrill R AU - Wadsworth, Helen M AD - Pepperdine U, Malibu CA 90265 & Veterans Administration Hospital, Cleveland OH 44106 Y1 - 1976/12// PY - 1976 DA - December 1976 SP - 951 EP - 957 VL - 43 IS - 3 SN - 0031-5125, 0031-5125 KW - concept-formation deficits assessment WAIS Vocabulary & Block Design, Halstead Category Test KW - brain damaged vs schizophrenic subjects KW - Schizophrenia (sc1) KW - Concept Formation and Identification (co9) KW - Diagnostic Testing (di2) KW - Nervous System Pathology (ne3) KW - Language Pathology (la4) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85433058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+Motor+Skills&rft.atitle=Assessment+of+Conceptual+Deficits+in+Brain-Damaged+and+Schizophrenic+Patients&rft.au=Holland%2C+Terrill+R%3BWadsworth%2C+Helen+M&rft.aulast=Holland&rft.aufirst=Terrill&rft.date=1976-12-01&rft.volume=43&rft.issue=3&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+Motor+Skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PMOSAZ N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Nervous System Pathology (ne3); Schizophrenia (sc1); Concept Formation and Identification (co9); Diagnostic Testing (di2) ER - TY - JOUR T1 - Word Retrieval of Aphasic Adults AN - 85509547; 7902861 AB - Ss were 18 aphasic adults whose conversations were recorded over time periods of one week to three months to determine (1) types of word-retrieval behaviors employed & (2) the degree to which identified behaviors were successful in prompting intended word production. Five retrieval behaviors - delay, semantic association, phonetic association, description, & generalization - were identified. It was possible to organize the Ss' retrieval behavior in a hierarchical efficiency order. A particular behavior's use & its success in producing an intended word appeared strongly related to aphasia severity. Findings point out the significance of associational processes to the word-retrieval problem in aphasia. Modified HA JF - Journal of Speech and Hearing Disorders AU - Marshall, Robert C AD - Veterans Administration Hospital, Portland OR 97207 Y1 - 1976/11// PY - 1976 DA - November 1976 SP - 444 EP - 451 VL - 41 IS - 4 KW - word-retrieval behaviors KW - adult aphasics KW - Language Pathology (la4) KW - Aphasia (ap1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85509547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Word+Retrieval+of+Aphasic+Adults&rft.au=Marshall%2C+Robert+C&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1976-11-01&rft.volume=41&rft.issue=4&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Pathology (la4); Aphasia (ap1) ER - TY - JOUR T1 - Relaxation Training: Effects on the Communicative Ability of Aphasic Adults AN - 85449813; 8203534 AB - Battery of 4 15-item verbal tests were administered to aphasic adults (N = 16) following a period of relaxation training or a control period. Results indicate that verbal communication of these Ss was positively influenced by relaxation training. Ss had significantly higher overall battery scores & naming test scores following relaxation. Therapeutic applications of the findings are discussed. 2 Tables. HA JF - Archives of Physical Medicine and Rehabilitation AU - Marshall, Robert C AU - Watts, Mary T AD - Veterans Administration Hospital, Sam Jackson Park Portland OR 97207 Y1 - 1976/10// PY - 1976 DA - October 1976 SP - 464 EP - 467 VL - 57 IS - 10 SN - 0003-9993, 0003-9993 KW - aphasics' speech therapy KW - relaxation training KW - adults KW - Speech Therapy (sp13) KW - Aphasia (ap1) KW - Adult Language (ad3) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85449813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Relaxation+Training%3A+Effects+on+the+Communicative+Ability+of+Aphasic+Adults&rft.au=Marshall%2C+Robert+C%3BWatts%2C+Mary+T&rft.aulast=Marshall&rft.aufirst=Robert&rft.date=1976-10-01&rft.volume=57&rft.issue=10&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHAI N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Speech Therapy (sp13); Adult Language (ad3) ER - TY - JOUR T1 - Marriage and Divorce after Spinal Cord Injury AN - 61040203; 81L5885 AB - The outcomes of marriages contracted after spinal cord injury suffered by males (number of cases = approximately 840) were examined via the questionnaire method. Of those whose first marriage occurred after their injury, the divorce rate was 24.4%. Of those who married prior to injury & then remarried following injury, 16.4% were divorced. If all the postinjury marriages are considered, the divorce rate is 23.1%, a figure close to the divorce rate of the United States as a whole. Outcomes of postinjury marriages were also examined with respect to time since injury, level of injury, presence of postinjury children, & postinjury education & employment. Particular attention was given to males who had never been married prior to injury. 4 Tables. Modified HA. JF - Archives of Physical Medicine and Rehabilitation AU - El Ghatit, Ahmed Z AU - Hanson, Richard W AD - Veterans Administration Center, Wood WI 53193 Y1 - 1976/10// PY - 1976 DA - October 1976 SP - 470 EP - 472 VL - 57 IS - 10 KW - marriage outcomes KW - males' spinal cord injury KW - questionnaires KW - Injury/Injuries KW - Divorce/Divorced KW - Marriage/Marriages/Marital KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61040203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Marriage+and+Divorce+after+Spinal+Cord+Injury&rft.au=El+Ghatit%2C+Ahmed+Z%3BHanson%2C+Richard+W&rft.aulast=El+Ghatit&rft.aufirst=Ahmed&rft.date=1976-10-01&rft.volume=57&rft.issue=10&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - APMHAI N1 - SubjectsTermNotLitGenreText - Marriage/Marriages/Marital; Injury/Injuries; Divorce/Divorced ER - TY - RPRT T1 - Completion Rates for Education and Training under the Vietnam Era GI Bill. A Study Submitted by the Veterans' Administration to the Committee on Veterans' Affairs, United States Senate. Ninety-Fourth Congress, 2nd Session. Senate Committee Print No. 48. AN - 63891357; ED139917 AB - A study was conducted by the Veterans' Administration in June 1976 to determine completion rates for education and training under the Vietnam Era GI Bill for veterans who had terminated training by June 1972. The study was based on responses to a questionnaire sent to a sample of Vietnam era veterans and summarizes their reported completion rates, current employment and earnings, degree or certificate earned, areas of training, and other factors. College and other resident school and on-job trainees had high completion rates but correspondence school trainees much lower ones. About half the discontinuances were due to financial problems together with job interference. Other responses indicated that the majority of the veterans completing training had lower unemployment rates, utilized their training at work, and had higher earnings than those not completing training. The questionnaire, discussion of results, and tabular data are included. (MF) Y1 - 1976/08/10/ PY - 1976 DA - 1976 Aug 10 SP - 32 KW - Vietnam Veterans KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Questionnaires KW - Training KW - Dropout Rate KW - Vocational Followup KW - Higher Education KW - Graduates KW - Participant Satisfaction KW - Enrollment Rate KW - Educational Benefits KW - Professional Training KW - College Graduates KW - Research KW - Technical Education KW - Graduate Surveys KW - Veterans Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63891357?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 2 - Produced in microfiche (1966-2003) N1 - SuppNotes - Not available in hard copy due to small print of o N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Training by Correspondence under the GI Bill (An In-Depth Analysis). A Study Submitted by the Veterans' Administration to the Committee on Veterans' Affairs United State Senate. 94th Congress, 2nd Session. Senate Committee Print No. 49. AN - 63885794; ED135977 AB - The analysis of correspondence training by service personnel and veterans was based upon and prepared from the file of veterans and service personnel who trained in correspondence schools under chapter 34 (GI bill) during June 1966 through December 1974. The overall results showed that (1) during this period, a total of 5.3 million persons had enrolled in training under the current GI bill, and of this total, 1.1 million had taken their most recent training by correspondence, and (2) a greater proportion of service personnel who trained have been correspondence trainees; however, because veterans make up the greater part of total trainees, the bulk of correspondence trainees (79%) are veterans. Other findings are presented under the following headings: Completion Rates, Average Cost, and Most Frequently Used Courses; Factors Influencing Correspondence Training; Costs and Benefits of Correspondence Training; Completion Rate Perspective; Comparison of the Status of Veteran Correspondence Trainees in November 1974 and April 1973; Completion Rate and Cost Effectiveness by Course of Training; Number of Trainees, Completion Percentages, and Cost Effectiveness by Course by School; and Correspondence Schools. Twenty-five tables supplement the study. (WL) Y1 - 1976/08/10/ PY - 1976 DA - 1976 Aug 10 SP - 53 KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Correspondence Schools KW - Higher Education KW - Graduates KW - Veterans KW - Correspondence Study KW - Comparative Analysis KW - Accreditation (Institutions) KW - Trainees KW - Military Personnel KW - Cost Effectiveness KW - Vocational Education KW - Research KW - Technical Education KW - Veterans Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63885794?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 2 - Produced in microfiche (1966-2003) N1 - SuppNotes - Not available in hard copy due to marginal reprodu N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Method: Melodic Intonation Therapy for Aphasia AN - 85509845; 7902933 AB - Melodic intonation therapy (MIT), a method developed to assist the adult aphasic regain verbal communication, is presented with step-by-step procedures & suggestions. The type of patient for whom the technique appears most successful is also described. Of 20 aphasic patients who received intonation therapy at the Boston's Veterans Administration Hospital, 14 improved while they had not improved in the previous six months of speech therapy. Patients who profited most from the treatments had only mild to moderate difficulties in auditory comprehension. Material samples are given in three appendices. In On: Melodic Intonation Therapy for Aphasia, Charles I. Berlin (Louisiana State U Medical Center, New Orleans 70119) discusses some possible explanations for the success of MIT in terms of brain physiology. 1 Figure. Modified HA JF - Journal of Speech and Hearing Disorders AU - Sparks, Robert W AU - Holland, Audrey L AD - Veterans Administration Hospital, Boston MA 02130 & U Pittsburg, PA 15261 Y1 - 1976/08// PY - 1976 DA - August 1976 SP - 287 EP - 297 VL - 41 IS - 3 KW - melodic intonation therapy for aphasia KW - Language Therapy (la7a) KW - Intonation (in17) KW - Speech Therapy (sp13) KW - Aphasia (ap1) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85509845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Method%3A+Melodic+Intonation+Therapy+for+Aphasia&rft.au=Sparks%2C+Robert+W%3BHolland%2C+Audrey+L&rft.aulast=Sparks&rft.aufirst=Robert&rft.date=1976-08-01&rft.volume=41&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - SuppNotes - Comment, 298-300. N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Therapy (la7a); Speech Therapy (sp13); Intonation (in17); Aphasia (ap1) ER - TY - RPRT T1 - Occupational Graduate Employment Report: An Analysis of the Fifty Percent Employment Criterion for VA Approved Vocational Courses. 1975 Survey. AN - 63896202; ED141570 AB - Public Law (P.L.) 93-508, enacted by the 93rd Congress, contains two sections which require a minimum employment standard of 50% for schools offering vocational courses to veteran trainees enrolled under the provisions of two chapters of the current (as of 1975) VA Educational Assistance Program. The VA Administration determined that in order for schools to comply with this requirement, they must submit acceptable evidence for each of the approved vocational courses to show that at least half of their graduates (students who completed all the academic requirements for the course, whether or not they received a diploma, degree, or certificate) in the most recent 2-year period are employed in the same field for which they trained or in a closely related field at a comparable level. This report discusses the procedures used in collecting and analyzing survey data to meet the 50% employment criterion, the conclusions, and the legislation. A major portion consists of tabular data collected from the school responses, presenting such information as the proportion of no response cases, completion rates, and ratio of respondents in closely related fields. (SH) Y1 - 1976/08// PY - 1976 DA - August 1976 SP - 366 KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Educational Legislation KW - Employment Statistics KW - Employment Opportunities KW - Graduates KW - Employment KW - Veterans KW - Student Financial Aid KW - Federal Legislation KW - Followup Studies KW - Statistical Data KW - Standards KW - Vocational Education KW - Tables (Data) KW - Graduate Surveys KW - Veterans Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/63896202?accountid=14244 LA - English DB - ERIC N1 - Availability - Level 1 - Available online, if indexed January 1993 onward N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Participatory Governance: A Model for Shared Decision Making AN - 61541534; 197900490 AB - The proposed governance model is characterized by a more responsible partnership between the social work administrator & staff. The governance component of administration is that parameter limited to the decision-making processes determining or affecting policies, procedures, & the direction in which goals, programs, & services will evolve. In the participatory-collateral governance model there is an assignment of flexible roles. Decision making is by explicitly delineated collateral participation of departmental staff at all levels. Prerequisites for implementing the model include: (1) the basic core of accountability rests with the individual staff member, (2) the professionally knowledgeable, administratively experienced or talented director must be sufficiently secure to risk self to reach for higher levels of departmental effectiveness, (3) director & staff must be confident in their shared capabilities to deliver a quality level of social services, (4) ideally, the time to initiate the model is when a relatively stable staff already exists, & (5) the director must work closely & sensitively with supervisors on all levels. Consideration is given to staff & organizational dynamics, & to some selected appropriate issues for collateral decision making. Some models of collateral governance are outlined. Use of an advisory committee is examined. Some risks of old & new governance forms are reviewed with recommendations to help reduce risks. W. A. Maesen. JF - Social Work in Health Care AU - Hirsch, Sidney AU - Shulman, Lawrence C AD - Veterans Administration Hospital, First Ave & E 24th St New York NY 10010 & Dept Social Work Services Long Island Jewish-Hillside Medical Center, NY Y1 - 1976/07// PY - 1976 DA - July 1976 SP - 433 EP - 446 VL - 1 IS - 4 SN - 0098-1389, 0098-1389 KW - Management Styles KW - Management KW - Superior Subordinate Relationship KW - Social Work KW - article KW - 6150: professional issues in social work UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61541534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Participatory+Governance%3A+A+Model+for+Shared+Decision+Making&rft.au=Hirsch%2C+Sidney%3BShulman%2C+Lawrence+C&rft.aulast=Hirsch&rft.aufirst=Sidney&rft.date=1976-07-01&rft.volume=1&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work; Management; Management Styles; Superior Subordinate Relationship ER - TY - JOUR T1 - An Assessment of the Utility of Suicide Prediction AN - 60875185; 77I3116 AB - An exploration of the fundamental question concerning the upper limits to which suicide predictions--a continually expressed objective of the study of suicide--can possibly aspire. Efforts to predict a future event assume varying levels of confidence depending on its base rate & the error rate of the prediction instrument. Most researchers working with suicide prediction instruments seem tacitly to assume they will be able to predict a future suicide most of the time. Applying basic decision theory on a neuropsychiatric hospital population indicates that the use of a prediction schedule will be unlikely to predict a future suicide beyond a 20% level of efficiency. Contrary to the general clinical view, eliminating false negatives was shown to be more practical than eliminating false positives in increasing the efficiency of a predictive schedule. 2 Tables. Modified HA. JF - Suicide and Life-Threatening Behavior AU - Mackinnon, Douglas R AU - Farberow, Norman L AD - Veterans Administration Wadsworth Hospital Center, Los Angeles CA Y1 - 1976/07// PY - 1976 DA - July 1976 SP - 86 EP - 91 VL - 6 IS - 2 SN - 0363-0234, 0363-0234 KW - suicide prediction KW - decision theory KW - neuropsychiatric population KW - Assess/Assesses/Assessment/ Assessments/ Assessing KW - Theory/Theories/Theorem/ Theorizing KW - Decision/Decisional/Decisions KW - Suicide/Suicides/Suicidal KW - Prevention/Preventive KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60875185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=An+Assessment+of+the+Utility+of+Suicide+Prediction&rft.au=Mackinnon%2C+Douglas+R%3BFarberow%2C+Norman+L&rft.aulast=Mackinnon&rft.aufirst=Douglas&rft.date=1976-07-01&rft.volume=6&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Assess/Assesses/Assessment/ Assessments/ Assessing; Suicide/Suicides/Suicidal; Prevention/Preventive; Decision/Decisional/Decisions; Theory/Theories/Theorem/ Theorizing ER - TY - JOUR T1 - Social Climate and Major Choice: A Test of Holland's Theory in University Student Living Groups AN - 60862584; 77I5242 AB - Concern is centered on 2 of the major relationships between human environment & human functioning: (1) dimensions identifying the human aggregate, & (2) dimensions related to the social climates of environments. The distribution of major choices of students in Coll living units, as determined by J. L. Holland's typology, was related to the characteristics of the social environments of the living units. The sample consisted of freshman students from 42 living units on 2 campuses. Data concerning major choice was obtained by asking 6 questions correlated with Holland's 6 vocational categories. Information on social climate was obtained from U Residence Environment Scale. Results supported Holland's theory in that these 2 sets of variables were predictably related. Results emphasize the role of social climate as a mediator between personality variables & the development of different types of occupational environments. Further study should concentrate on differences in major field choices, & thus aid the study of relations between degrees of homogeneity & social environment, & between social climate & major choice. 1 Figure, 3 Tables. Modified HA. JF - Journal of Vocational Behavior AU - Hearn, James C AU - Moos, Rudolf H AD - Stanford U, CA 94305 & Veterans Administration Hospital, Palo Alto CA 94304 Y1 - 1976/06// PY - 1976 DA - June 1976 SP - 293 EP - 305 VL - 8 IS - 3 SN - 0001-8791, 0001-8791 KW - social climate vs human functioning, Holland's theory, test KW - university students' living groups, major choices vs environment, data, results KW - Functioning KW - Climate/Climates KW - Theory/Theories/Theorem/ Theorizing KW - Group/Groups/Grouping/Groupism KW - Human/Humans/Humanity KW - Student/Students KW - Social KW - Living KW - Test/Tests (see also~Scale, Index, Score also specific tests) KW - University/Universities KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60862584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vocational+Behavior&rft.atitle=Social+Climate+and+Major+Choice%3A+A+Test+of+Holland%27s+Theory+in+University+Student+Living+Groups&rft.au=Hearn%2C+James+C%3BMoos%2C+Rudolf+H&rft.aulast=Hearn&rft.aufirst=James&rft.date=1976-06-01&rft.volume=8&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vocational+Behavior&rft.issn=00018791&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JVBHA2 N1 - SubjectsTermNotLitGenreText - University/Universities; Theory/Theories/Theorem/ Theorizing; Test/Tests (see also~Scale, Index, Score also specific tests); Student/Students; Living; Group/Groups/Grouping/Groupism; Climate/Climates; Social; Human/Humans/Humanity; Functioning ER - TY - JOUR T1 - EARLY INDICES OF CANCER RISK AMONG URANIUM MINERS WITH REFERENCE TO MODIFYING FACTORS* AN - 867746816; 14668678 JF - Annals of the New York Academy of Sciences AU - Saccomanno, Geno AU - Archer, Victor E AU - Saunders, Richard P AU - Auerbach, Oscar AU - Klein, M G AD - Department of Pathology St. Mary's and Veterans Administration Hospitals Grand Junction, Colorado 81501 Y1 - 1976/05// PY - 1976 DA - May 1976 SP - 377 EP - 383 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 271 IS - 1 SN - 0077-8923, 0077-8923 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Mining KW - Occupational safety KW - Uranium KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867746816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=EARLY+INDICES+OF+CANCER+RISK+AMONG+URANIUM+MINERS+WITH+REFERENCE+TO+MODIFYING+FACTORS*&rft.au=Saccomanno%2C+Geno%3BArcher%2C+Victor+E%3BSaunders%2C+Richard+P%3BAuerbach%2C+Oscar%3BKlein%2C+M+G&rft.aulast=Saccomanno&rft.aufirst=Geno&rft.date=1976-05-01&rft.volume=271&rft.issue=1&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.1976.tb23134.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Uranium; Occupational safety; Mining; Cancer DO - http://dx.doi.org/10.1111/j.1749-6632.1976.tb23134.x ER - TY - JOUR T1 - Therapeutic Approaches to Apraxia AN - 58068127; 7902908 AB - Although identifying descriptions of apraxia are numerous in recent literature, few articles present guidelines for apraxia therapy. Several therapeutic techniques for apraxia are introduced & discussed. Speech sound sequencing is recognized as the apraxic patient's most characteristic problem. Rapid repetition of cons plus /(script a)/, build up of speech sounds into syllables, & word attack by phone & syllable are all recommended for improving sequencing. Facilitation techniques are discussed for the acquisition of articulatory postures. Case histories are presented to illustrate the therapy approach. Modified HA JF - Journal of Speech and Hearing Disorders AU - Dabul, Barbara AU - Bollier, Betty AD - Veterans Administration Outpatient Clinic, 425 South Hill St Los Angeles CA 90013 & Los Angeles Unified School District, CA 90053 Y1 - 1976/05// PY - 1976 DA - May 1976 SP - 268 EP - 276 VL - 41 IS - 2 KW - therapeutic approaches to apraxia KW - Language Therapy (la7a) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Therapeutic+Approaches+to+Apraxia&rft.au=Dabul%2C+Barbara%3BBollier%2C+Betty&rft.aulast=Dabul&rft.aufirst=Barbara&rft.date=1976-05-01&rft.volume=41&rft.issue=2&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Therapy (la7a) ER - TY - JOUR T1 - Acquisition of Esophageal Speech Subsequent to Learning Pharyngeal Speech: An Unusual Case Study AN - 58068007; 7902874 AB - Laryngectomees delayed in obtaining alaryngeal voice therapy may develop pharyngeal voice, an undesirable type of alaryngeal voice. Pharyngeal voice is usually self-developed; however, it may also be acquired in the clinical setting when the patient is being taught to inject air for esophageal sound production. Principal findings involving a laryngectomee who had developed & used pharyngeal speech as the primary communication method for two years prior to enrollment in alaryngeal voice therapy are described. A clinical technique successful in altering the pharyngeal voice to esophageal voice is reported. Findings on the overall intelligibility & vocal fundamental f of the two types of alaryngeal speech are included. Modified HA JF - Journal of Speech and Hearing Disorders AU - Torgerson, John K AU - Martin, Daniel E AD - Veterans Administration Hospital, 4150 Clement San Francisco CA 94121 48232 Y1 - 1976/05// PY - 1976 DA - May 1976 SP - 233 EP - 237 VL - 41 IS - 2 KW - esophageal speech acquisition subsequent to pharyngeal speech development KW - case study KW - Intelligibility (in11) KW - Eskimo/Aleut (es1) KW - Language Therapy (la7a) KW - Laryngectomy (la11) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58068007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Acquisition+of+Esophageal+Speech+Subsequent+to+Learning+Pharyngeal+Speech%3A+An+Unusual+Case+Study&rft.au=Torgerson%2C+John+K%3BMartin%2C+Daniel+E&rft.aulast=Torgerson&rft.aufirst=John&rft.date=1976-05-01&rft.volume=41&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Language Therapy (la7a); Eskimo/Aleut (es1); Laryngectomy (la11); Intelligibility (in11) ER - TY - JOUR T1 - Hemodynamic Changes Associated With Angina Pectoris Induced By Maximal Treadmill Exercise: Effect of Sublingual Isosorbide Dinitrate On Systolic Time Intervals AN - 20075372; 10097862 JF - Angiology AU - Thompson, Eugene J AU - Glass, Paul AU - Ansari, Abdul AU - Arora, Jodh AD - Veterans Administration Hospital Brooklyn, N.Y. 11209 Y1 - 1976/05// PY - 1976 DA - May 1976 SP - 269 EP - 279 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 27 IS - 5 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Hemodynamics KW - Exercise (effects) KW - Treadmill ergometry KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20075372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Hemodynamic+Changes+Associated+With+Angina+Pectoris+Induced+By+Maximal+Treadmill+Exercise%3A+Effect+of+Sublingual+Isosorbide+Dinitrate+On+Systolic+Time+Intervals&rft.au=Thompson%2C+Eugene+J%3BGlass%2C+Paul%3BAnsari%2C+Abdul%3BArora%2C+Jodh&rft.aulast=Thompson&rft.aufirst=Eugene&rft.date=1976-05-01&rft.volume=27&rft.issue=5&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331977602700501 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hemodynamics; Exercise (effects); Treadmill ergometry; Heart diseases DO - http://dx.doi.org/10.1177/000331977602700501 ER - TY - JOUR T1 - Some side-effects of alpha-methyldopa. AN - 83393628; 1224274 AB - Three different regimens of drug treatment for hypertension were compared with regard to the development of undesirable side-effects in a group of 53 patients attending a hypertension clinic. The combination of alpha-methyldopa and chlorthalidone produced the highest incidence of side-effects. Weakness and impotence were most frequently encountered. In contrast, the combination of chlorthalidone, hydralazine and propranolol, and chlorthalidone alone, produced fewer side-effects. It is recommended that alpha-methyldopa should not be a first choice in the treatment of hypertension. JF - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde AU - Pillay, V K AD - Veterans Administration West Side Hospital and Abraham Lincoln School of Medicine, University of Illinois, Chicago, Illinois USA. Y1 - 1976/04/10/ PY - 1976 DA - 1976 Apr 10 SP - 625 EP - 626 VL - 50 IS - 16 SN - 0256-9574, 0256-9574 KW - Hydralazine KW - 26NAK24LS8 KW - Methyldopa KW - 56LH93261Y KW - Propranolol KW - 9Y8NXQ24VQ KW - Chlorthalidone KW - Q0MQD1073Q KW - Index Medicus KW - Erectile Dysfunction -- chemically induced KW - Drug Therapy, Combination KW - Chlorthalidone -- adverse effects KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Hydralazine -- adverse effects KW - Propranolol -- adverse effects KW - Male KW - Hypertension -- drug therapy KW - Methyldopa -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/83393628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=South+African+medical+journal+%3D+Suid-Afrikaanse+tydskrif+vir+geneeskunde&rft.atitle=Some+side-effects+of+alpha-methyldopa.&rft.au=Pillay%2C+V+K&rft.aulast=Pillay&rft.aufirst=V&rft.date=1976-04-10&rft.volume=50&rft.issue=16&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=South+African+medical+journal+%3D+Suid-Afrikaanse+tydskrif+vir+geneeskunde&rft.issn=02569574&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1976-07-06 N1 - Date created - 1976-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaction Effects of Synonymity, Intralist Synonym Cohesiveness, and List Length in Multi-Trial Free Recall AN - 85510000; 7903007 AB - In each of three experiments, different lists of synonymous & minimally related adjs were presented to groups of Ss for multitrial free recall. The synonym list in experiment 1 (N = 162) contained twenty adjs denoting positive affect; short & long lists of eight & twenty items were used. In experiment 2, the list contained twenty-two adjs having negative connotations; lists of eight, fifteen, & twenty-two items were used. In experiment 3, only twenty-item lists were used. The synonym category contained adjs denoting "large magnitude." In experiment 4, five measures of semantic cohesiveness were derived from a series of five tasks (N = 48). Results in experiment 1 supported the hypothesis of interaction of synonymity & list length on recall & organization, predicting impaired performance on long lists of synonyms. Two partial replications (experiments 2 & 3) obtained negative results. Measures in experiment 4 were used to verify the high degree of semantic similarity in the three experimental lists. It was concluded that list synonymity has a differential effect primarily on the retrieval strategies employed & that Ss are still able to achieve optimal recall & organization with lists of high intralist similarity. 2 Tables. Modified HA JF - Psychological Reports AU - Abramczyk, Rudolf R AU - Thompson, W Douglas AU - Jordan, Donald E AU - Weeks, Robert A AD - Psychology Service Veterans Administration Hospital, 555 Willard Ave Newington CT 06111 Y1 - 1976/04// PY - 1976 DA - April 1976 SP - 507 EP - 521 VL - 38 IS - 2 SN - 0033-2941, 0033-2941 KW - synonymity interaction effects, intralist synonym cohesiveness, list length in multitrial free recall KW - Adjective (ad1) KW - Psycholinguistics (ps3) KW - Unaided Recall (un1) KW - Verbal Learning (ve2) KW - Synonym (sy2) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85510000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Reports&rft.atitle=Interaction+Effects+of+Synonymity%2C+Intralist+Synonym+Cohesiveness%2C+and+List+Length+in+Multi-Trial+Free+Recall&rft.au=Abramczyk%2C+Rudolf+R%3BThompson%2C+W+Douglas%3BJordan%2C+Donald+E%3BWeeks%2C+Robert+A&rft.aulast=Abramczyk&rft.aufirst=Rudolf&rft.date=1976-04-01&rft.volume=38&rft.issue=2&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Psychological+Reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PYRTAZ N1 - SubjectsTermNotLitGenreText - Psycholinguistics (ps3); Verbal Learning (ve2); Unaided Recall (un1); Adjective (ad1); Synonym (sy2) ER - TY - JOUR T1 - Retention of phonemic and semantic features of words. AN - 853227174; pmid-21287020 AB - Subjects were asked to detect either repetitions, rhymes, or words from the same category during an auditory or visual list presentation. It was discovered in both cases that the number of intervening words had a differential effect on probability of detection, with phonemic feature detection deteriorating more rapidly than semantic. However, "rate" of presentation did not have a differential effect on the probability of feature detection, since phonemic and semantic feature detection improved equally with increased interword interval time. It was suggested that phonemic feature retention might be more vulnerable than semantic feature retention to interference. JF - Memory & cognition AU - Cermak, L S AU - Youtz, C P AD - Psychology Service, Boston Veterans Administration Hospital, 150 South Huntington Avenue, 02130, Boston, Massachusetts. Y1 - 1976/03// PY - 1976 DA - Mar 1976 SP - 172 EP - 175 VL - 4 IS - 2 SN - 0090-502X, 0090-502X KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853227174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Memory+%26+cognition&rft.atitle=Retention+of+phonemic+and+semantic+features+of+words.&rft.au=Cermak%2C+L+S%3BYoutz%2C+C+P&rft.aulast=Cermak&rft.aufirst=L&rft.date=1976-03-01&rft.volume=4&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Memory+%26+cognition&rft.issn=0090502X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Personality Correlates of Male Sexual Arousal and Behavior AN - 60872685; 77I4694 AB - The relationship between personality factors & M sexual behavior was investigated using the MMPI & the Sensation Seeking Scale developed by M. Zuckerman (MANUAL AND RESEARCH REPORT FOR THE SENSATION SEEKING SCALE, Unpublished manuscript, U of Delaware, 1972) with 20 M S's between 19 & 58 years old. S's kept a one month daily tally record of sexual behavior; later interviews corroborated the accuracy of self-reports. MMPI/SSS measures were correlated with sexual behavior f. Introversion & depression evidenced a significant r with autoerotic stimulation & arousal; this was not true for heterosexual activity. Hypomania & sexual activity did not appear to be significantly correlated. Defensiveness appeared to be significantly related to a decrease in sexual arousal & behavior & in activities of a sensation seeking nature. The SSS Boredom Susceptibility subscale was highly correlated with the number of sexual partners. 2 Tables. J. N. Mayer. JF - Archives of Sexual Behavior AU - Husted, June R AU - Edwards, Allan E AD - Veterans Administration Hospital, Long Beach CA & Wadsworth VA Hospital Center, Los Angeles CA Y1 - 1976/03// PY - 1976 DA - March 1976 SP - 149 EP - 156 VL - 5 IS - 2 SN - 0004-0002, 0004-0002 KW - male sexual arousal, behavior vs personality correlates KW - scales, introversion, autoerotic stimulation, hypomania, defensiveness, boredom KW - Sexual/Sexuality/Sexually KW - Personality/Personalities KW - Behavior/Behavioral KW - Arouse/Arousal/Aroused KW - Correlates KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60872685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Personality+Correlates+of+Male+Sexual+Arousal+and+Behavior&rft.au=Husted%2C+June+R%3BEdwards%2C+Allan+E&rft.aulast=Husted&rft.aufirst=June&rft.date=1976-03-01&rft.volume=5&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASXBA8 N1 - SubjectsTermNotLitGenreText - Personality/Personalities; Sexual/Sexuality/Sexually; Correlates; Arouse/Arousal/Aroused; Behavior/Behavioral ER - TY - JOUR T1 - SMOKING CESSATATION AND SEX ROLE CONVERGENCE AN - 60865320; 76I1715 AB - THERE IS EVIDENCE SUGGESTING THAT SEX ROLE DIFFERENCES ARE IN PART CULTURALLY TRANSMITTED. THIS WORK EXAMINES THE POSSIBILITY THAT THERE IS CONVERGENCE OF SMOKING CESSATION RATES, AS REGARDS THE SIMILARITY BETWEEN THE SEXES. ON THE BASIS OF THE EQUALITARIAN SHIFT, IT IS PROPOSED "THAT THE DIFFERENCE IN AMOUNT OF QUITTING BETWEEN M'S & F'S DOES DECREASE FROM OLDER TO YOUNGER AGE GROUPS," & THAT "THERE IS A DIMINISHED SEX DIFFERENTIAL WHEN SMOKING CESSATION IS RELATED TO INTERPERSONAL FACTORS." DATA USED ARE FROM A NATIONAL PROBABILITY SAMPLE (N=5,704) COLLECTED IN 1966 BY NATIONAL ANALYSTS INC & BY OPINION RESEARCH CORP FOR THE NATIONAL CLEARINGHOUSE FOR SMOKING & HEALTH. COHORT ANALYSIS WAS BASED ON 6 BIRTH YEAR GROUPINGS. FINDINGS SUPPORT THE HYPOTHESIS THAT THE SEX DIFFERENTIAL IN FAVOR OF MORE M'S QUITTING IS VANISHING AT YOUNGER AGES. F QUITTERS OUTNUMBER THE M'S IN THE MOST RECENT BIRTH YEARS. ANOTHER FINDING SHOWS THAT THE SEXES AT OLDER AGES ARE SIMILAR IN RESPONSE TO THE INTERPERSONAL FACTOR. ALSO, THAT THERE IS A CONVERGENCE IN SMOKING CESSATION RATES OF THE SEXES FOR THOSE OF MORE RECENT BIRTH YEARS. F'S IN THE 3 MIDDLE BIRTH YEAR COHORTS WERE FOUND TO BE LESS SUSCEPTIBLE TO THE INTERPERSONAL FACTOR & THE INTERPERSONAL FACTOR WAS FOUND TO BE MORE IMPORTANT THAN AGE FOR SMOKING CESSATION. 1 GRAPH, 2 TABLES. MODIFIED HA. JF - Journal of Health and Social Behavior AU - Bosse, Raymond AU - Rose, Charles L AD - VETERANS ADMINISTRATION OUTPATIENT CLINIC, BOSTON MA 02132 Y1 - 1976/03// PY - 1976 DA - March 1976 SP - 53 EP - 61 VL - 17 IS - 1 SN - 0022-1465, 0022-1465 KW - SEX DIFFERENTIAL IN SMOKING CESSATION KW - Smoking KW - Sex/Sexes/Sexism/Sexist/Sexists KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60865320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+and+Social+Behavior&rft.atitle=SMOKING+CESSATATION+AND+SEX+ROLE+CONVERGENCE&rft.au=Bosse%2C+Raymond%3BRose%2C+Charles+L&rft.aulast=Bosse&rft.aufirst=Raymond&rft.date=1976-03-01&rft.volume=17&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+and+Social+Behavior&rft.issn=00221465&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JHSBA5 N1 - SubjectsTermNotLitGenreText - Sex/Sexes/Sexism/Sexist/Sexists; Smoking ER - TY - JOUR T1 - Recovery of Verbal Short-Term Memory in Alcoholics AN - 85434618; 8101672 AB - Alcoholic patients (N = 20) admitted to a hospital in an intoxicated state were tested for verbal short-term memory. Half of the Ss were tested on the day after admission, after one week, & after one month. The other 50% were first tested one month after admission, & then at the same intervals. Each group was subdivided by age: 50% were under 40 & 50% were over 50. Performance of both groups on a test involving memory for word triads was compared with performance of 8 Korsakoff patients. Results indicated that the hypothesis that alcoholics have a temporary impairment in ability to memorize new material may apply only to older Ss. In initial testing, older Ss in the recently intoxicated group performed much like Korsakoff patients. However, this performance improved over the one-month period, while performance for the Korsakoff group did not. Implications of these findings for verbal therapy with alcoholic patients are discussed. 3 Figures. B. Annesser JF - Journal of Studies on Alcohol AU - Cermak, Laird S AU - Ryback, Ralph S AD - Boston Veterans Administration Hospital, MA 02130 Y1 - 1976/01// PY - 1976 DA - January 1976 SP - 46 EP - 57 VL - 37 IS - 1 SN - 0096-882X, 0096-882X KW - verbal short-term memory recovery KW - age KW - alcoholic vs Korsakoff patients KW - Neurotic Disorders (ne4) KW - Verbal Learning (ve2) KW - Short-Term Memory (sh2) KW - Age Differences in Language (ag1) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85434618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Recovery+of+Verbal+Short-Term+Memory+in+Alcoholics&rft.au=Cermak%2C+Laird+S%3BRyback%2C+Ralph+S&rft.aulast=Cermak&rft.aufirst=Laird&rft.date=1976-01-01&rft.volume=37&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Short-Term Memory (sh2); Neurotic Disorders (ne4); Verbal Learning (ve2); Age Differences in Language (ag1) ER - TY - JOUR T1 - An Experimental Use of Structured Techniques in Group Psychotherapy AN - 60832046; 79J9643 AB - The use of the typical kinds of group therapy methods seemed to be becoming less effective with one group of patients making up the population of the Day Treatment Center. The ventilation & verbalization about past experiences normally done previously did not yield results for this group of long-term psychiatric patients. The group had reached a plateau where improvement in social skills & personal problem-solving ability were no longer evident. The number of absences increased, & there was an attitude of general disinterest in the purpose of the group. The experimental group was exposed to a period of very structured setting in group therapy. The members were verbal & displayed some evidence of insight & an ability to problem-solve. Originally there were 14 members of the group. Eight of them were diagnosed as schizophrenic reaction, 2 were diagnosed as psychoneurotic, 1 an active depressive, 1 a chronic brain syndrome, & 1 arteriosclerosis. One of the schizophrenic patients also had had 2 lobotomies. The structured techniques included the following therapy medias: simplified encounter & sensitivity training, self-improvement exploration, life enrichment experiences, tell-a-story, & weekly goal setting & reward. The therapist shared with the group methods for evaluating their progress, & they were encouraged to assist in the evaluation. An increase of interest was shown by the members wishing to continue the structured type of group therapy. There was an increase of 23% in attendance during the experimental period. In the self-evaluations, the members recorded that they had made improvement in from 1 to 17 areas. The therapist recorded improvement among the members in from 2 to 11 areas. The amount of awareness was increased; ie, awareness of others, objects, & their own needs. The therapist felt that the forward motion of the members was just beginning at the end of the experimental period, & it did indeed take a lot of time to develop awareness, break down barriers, & replace them with hopefulness & a desire to live for today instead of in the past. More body-image type sessions should be used since this was the most anxiety-producing area, & the area where the most help is needed for these people. The group was able to handle the evaluative process very well & showed a great deal of interest in that part of the experimental period. Patients are capable of self-evaluation if given encouragement & direction without criticism. AA. JF - Group Psychotherapy, Psychodrama and Sociometry AU - Kaseman, Betty M AD - Veterans Administration Outpatient Clinic, San Diego CA 92108 Y1 - 1976///0, PY - 1976 DA - 0, 1976 SP - 33 EP - 39 VL - 29 KW - experimental group, structured techniques in group psychotherapy KW - interest, attendance, work, goals, self-evaluations, long-term psychiatric patients KW - Goal/Goals KW - Patient/Patients KW - Experiment/Experiments/Experimental/ Experimenter/ Experimentation/ Experimentalism KW - Psychotherapy/Psychotherapeutic KW - Structure/Structures/ Structuring/ Structured KW - Group/Groups/Grouping/Groupism KW - Technique/Techniques KW - article KW - 0309: social psychology; interaction within (small) groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60832046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Group+Psychotherapy%2C+Psychodrama+and+Sociometry&rft.atitle=An+Experimental+Use+of+Structured+Techniques+in+Group+Psychotherapy&rft.au=Kaseman%2C+Betty+M&rft.aulast=Kaseman&rft.aufirst=Betty&rft.date=1976-01-01&rft.volume=29&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Group+Psychotherapy%2C+Psychodrama+and+Sociometry&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GPPSDX N1 - SubjectsTermNotLitGenreText - Experiment/Experiments/Experimental/ Experimenter/ Experimentation/ Experimentalism; Structure/Structures/ Structuring/ Structured; Technique/Techniques; Group/Groups/Grouping/Groupism; Psychotherapy/Psychotherapeutic; Patient/Patients; Goal/Goals ER - TY - JOUR T1 - The Tracking ABLB in Clinical Recruitment Testing AN - 58070739; 7904500 AB - The tracking ABLB originally described by Miskolczy-Fodor was compared to standard ABLB in 15 normal (median age 24.5 years) & 30 (median age 46.9 years) Ss with asymmetric & unilateral sensorineural losses, using a modification of the procedure. Six conditions (three speeds & two ear conditions) were presented in random order; Ss indicated loudness by a raised hand (standard) or by movement on a graph (tracking). Overshoot artifacts were noted in the results for normal Ss. Compared to the standard ABLB, the tracking method overstated recruitment when the variable tone was directed to the poorer ear, & understated it when the variable tone was directed to the better ear. Combining the better & poorer ear results did come close to standard ABLB findings, but over- & undershoot artifacts make the tracking procedure undesirable for experimental & research applications. 1 Table, 4 Figures. Modified HA JF - The Journal of Auditory Research AU - Gelfand, Stanley A AD - Veterans Administration Hospital, East Orange NJ 07019 Y1 - 1976/01// PY - 1976 DA - January 1976 SP - 34 EP - 41 VL - 16 IS - 1 KW - tracking vs standard ABLB procedure KW - normal, hearing-impaired subjects KW - Hearing Disorders (he3a) KW - Audiology (au2) KW - Audiometry (au3) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58070739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Auditory+Research&rft.atitle=The+Tracking+ABLB+in+Clinical+Recruitment+Testing&rft.au=Gelfand%2C+Stanley+A&rft.aulast=Gelfand&rft.aufirst=Stanley&rft.date=1976-01-01&rft.volume=16&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Auditory+Research&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAURAE N1 - SubjectsTermNotLitGenreText - Audiology (au2); Hearing Disorders (he3a); Audiometry (au3) ER - TY - JOUR T1 - Patient-Controlled Delivery of Monosyllabic Words in a Test of Auditory Discrimination AN - 58069116; 7902828 AB - Fifteen normal-hearing Ss & 15 with sensorineural hearing loss repeated monosyllabic words under a conventional & S-controlled presentation method at 0, 8, 16, & 44 db SL. Results showed little difference between discrimination scores obtained with the two presentation methods, supporting their interchangeable use. Clinical usefulness of the free operant (FO) method is outlined for Ss having difficulty responding at a conventional predetermined rate: time may be saved & interest maintained. The majority of Ss in both groups preferred the self-controlled presentation method. 2 Tables. Modified HA JF - Journal of Speech and Hearing Disorders AU - McLennan, Roderick O, Jr AU - Knox, Albert W AD - Veterans Administration Hospital, 4801 Linwood Kansas City MO 64128 Y1 - 1975/11// PY - 1975 DA - November 1975 SP - 538 EP - 543 VL - 40 IS - 4 KW - subject-controlled vs conventional presentation, auditory discrimination test, monosyllabic words KW - normal-hearing vs sensorineural hearing loss subjects KW - Hearing Disorders (he3a) KW - Auditory Stimulation (au7) KW - Word (wo1) KW - Discrimination Learning (di7) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58069116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech+and+Hearing+Disorders&rft.atitle=Patient-Controlled+Delivery+of+Monosyllabic+Words+in+a+Test+of+Auditory+Discrimination&rft.au=McLennan%2C+Roderick+O%2C+Jr%3BKnox%2C+Albert+W&rft.aulast=McLennan&rft.aufirst=Roderick&rft.date=1975-11-01&rft.volume=40&rft.issue=4&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech+and+Hearing+Disorders&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSHDAX N1 - SubjectsTermNotLitGenreText - Hearing Disorders (he3a); Auditory Stimulation (au7); Discrimination Learning (di7); Word (wo1) ER - TY - JOUR T1 - Assessing Treatment Outcome. I. Adjustment in the Community AN - 60867302; 77I7201 AB - In recent years, the reexamination of treatment outcome has substantially advanced the sophistication with which the issues involved have been conceptualized. A study of consecutively admitted M psychiatric patients (both psychotic & nonpsychotic) was directed toward the empirical elaboration of 4 of these issues as they relate to adjustment in the community. The issues may be stated as the extent to which: (1) a common outcome pattern exists across different dimensions of adjustment, (2) the vantage point of the observer influences adjustment ratings, (3) judgments of overall improvement encompass the major dimensions of adjustment, & (4) judgments of overall improvements represent changes in adjustment levels. For about 70 patients out of the original 171 admissions, ratings on 5 adjustment dimensions (symptomology, alcohol abuse, social involvement, employment, & organizational participation) were made shortly after admission & 1 & 6 months after discharge by patients & a significant other (usually a family member). Adjustments were compared by means of a series of factorial analyses of variance for repeated measures. With regard to the 1st issue, the data indicate that each major dimension of adjustment has a somewhat different pattern over time. A substantial consensus exists between patients & their significant others concerning patients' adjustment relative to the adjustment of other patients as described by them & their significant others, although not in terms of the actual magnitude of their adjustment. Global improvement ratings are related to 2 dimensions of adjustment primarily (symptomology & social involvement), & they are virtually unrelated to other major dimensions. Global improvement ratings are highly reflective of the current level of adjustment. The relevance of these findings to outcome assessment is discussed & some suggestions are offered. 4 Tables. Modified HA. JF - The Journal of Nervous and Mental Disease AU - Fontana, Alan F AU - Dowds, Barbara Noel AD - Veterans Administration Hospital, West Spring St West Haven CT 06516 & Yale U School Medicine, New Haven CT 06520 Y1 - 1975/10// PY - 1975 DA - October 1975 SP - 221 EP - 230 VL - 161 IS - 4 KW - psychiatric patients, treatment outcome assessment vs community adjustment KW - common pattern, observer bias, dimensions discussion, study design, global improvement ratings KW - Assess/Assesses/Assessment/ Assessments/ Assessing KW - Patient/Patients KW - Psychiatry/Psychiatric KW - Community/Communities/Communitarian KW - Result/Results KW - Treatment KW - Adjustment/Adjustments KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60867302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Nervous+and+Mental+Disease&rft.atitle=Assessing+Treatment+Outcome.+I.+Adjustment+in+the+Community&rft.au=Fontana%2C+Alan+F%3BDowds%2C+Barbara+Noel&rft.aulast=Fontana&rft.aufirst=Alan&rft.date=1975-10-01&rft.volume=161&rft.issue=4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nervous+and+Mental+Disease&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JNMDAN N1 - SubjectsTermNotLitGenreText - Adjustment/Adjustments; Community/Communities/Communitarian; Psychiatry/Psychiatric; Patient/Patients; Treatment; Result/Results; Assess/Assesses/Assessment/ Assessments/ Assessing ER - TY - JOUR T1 - Some Phonemic Characteristics in Apraxia of Speech AN - 85483997; 7601955 AB - The articulatory performance of 13 left hemisphere-damaged adults with speech apraxia was tabulated on confusion matrices & analyzed according to error pattern. Consonants were more susceptible to error than were vowels, as were consonant clusters when compared to single consonants. No significant differences existed among error percentages for the initial, medial, & final positions. When errors were analyzed according to manner of production, affricatives & fricatives were most susceptible to error. Error analysis according to place of production revealed lingual alveolar & bilabial phonemes to be significantly less impaired than all others. No differences were found in error percentages of voiced & unvoiced phonemes. The sequential nature of substitution errors was further analyzed by classifying errors as anticipatory, reiterative, or metathesis. 7% of the substitution errors were sequential, with anticipatory errors outnumbering reiterative errors by 6 to 1. Feature analysis of substitutions to determine distance from the target sound revealed that 38% of the substitutions were defective in 2 or more features. Some of these substitutions had little subjective resemblance to the target sound. HA JF - Journal of Communication Disorders AU - La Pointe, Leonard L AU - Johns, Donnell F AD - Veterans Administration Hospital, Gainesville FL 32602 Y1 - 1975/09// PY - 1975 DA - September 1975 SP - 259 EP - 269 VL - 8 IS - 3 SN - 0021-9924, 0021-9924 KW - articulatory performance analyzed by error pattern, speech apraxia KW - left hemisphere-damaged adults KW - Vowel (vo4) KW - Consonant (co14) KW - Articulatory Phonetics (ar5) KW - Cerebral Dominance (ce2) KW - Phonemes (ph5a) KW - Nervous System Pathology (ne3) KW - Experimental Data Handling (ex2) KW - Articulation Disorders (ar4) KW - article KW - 6110: phonetics; phonetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85483997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Some+Phonemic+Characteristics+in+Apraxia+of+Speech&rft.au=La+Pointe%2C+Leonard+L%3BJohns%2C+Donnell+F&rft.aulast=La+Pointe&rft.aufirst=Leonard&rft.date=1975-09-01&rft.volume=8&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Articulatory Phonetics (ar5); Nervous System Pathology (ne3); Cerebral Dominance (ce2); Articulation Disorders (ar4); Consonant (co14); Vowel (vo4); Experimental Data Handling (ex2); Phonemes (ph5a) ER - TY - JOUR T1 - Impedance Audiometry with Retardates AN - 85441761; 7904553 AB - Given the much higher than usual incidence of middle-ear pathology among mental retardates, it becomes imperative to establish the most effective screening procedures. Thirty Ss (aged eleven to sixty-two) from an institution for the mentally retarded underwent otoscopy & middle-ear impedance testing with two commercial instruments. "Hard" impedance signs identified all five Ss with otoscopically designated otic pathology. Inclusion of "soft" signs identified twelve additional Ss classified negative by otoscopy. While significance of all soft signs is uncertain, & while there is no obvious relation between retardation level & otological findings, it is recommended that complete tympanograms & acoustic impedance measures be included in routine middle-ear exams for all mental retardates. 4 Tables. Modified HA JF - The Journal of Auditory Research AU - Wooten, Philip G AU - Sheeley, Eugene C AU - Hannah, Joseph E AD - Veterans Administration Hospital, Birmingham AL 35233 Y1 - 1975/07// PY - 1975 DA - July 1975 SP - 156 EP - 161 VL - 15 IS - 3 KW - impedance audiometry, middle-ear pathology KW - mental retardates aged 11 to 62 KW - Middle Ear (mi1) KW - Mental Retardation (me7) KW - Audiometry (au3) KW - article KW - 6610: mental retardation; mental retardation KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Auditory+Research&rft.atitle=Impedance+Audiometry+with+Retardates&rft.au=Wooten%2C+Philip+G%3BSheeley%2C+Eugene+C%3BHannah%2C+Joseph+E&rft.aulast=Wooten&rft.aufirst=Philip&rft.date=1975-07-01&rft.volume=15&rft.issue=3&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Auditory+Research&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAURAE N1 - SubjectsTermNotLitGenreText - Audiometry (au3); Mental Retardation (me7); Middle Ear (mi1) ER - TY - JOUR T1 - Help for the Dying AN - 60848850; 77I5776 AB - After decades of relative silence about death & dying, these topics are now being widely studied & discussed. This new openness provides encouragement for hospital social workers to recognize the social-emotional needs of terminally ill patients & their families & to reach out to them in an effort to meet those needs. Social workers can help dying patients & their family members: (1) plan for the patient's remaining time, (2) explore their feelings about the imminence of death, (3) cope with the attendant intra- & interpersonal stresses, (4) plan for the patient's death, & (5) develop plans for sustaining the family after the patient's death. At times the social worker may also have the opportunity to offer support to the family immediately following the patient's death. AA. JF - Social Work AU - Pilsecker, Carleton AD - Veterans Administration Hospital, 5901 E 7th St Long Beach CA 90822 Y1 - 1975/05// PY - 1975 DA - May 1975 SP - 190 EP - 194 VL - 20 IS - 3 SN - 0037-8046, 0037-8046 KW - death, social worker's role evaluation KW - social, emotional needs, patients, families, help areas, support KW - Death/Deaths (see also Mortality, Dying) KW - Role/Roles KW - Evaluation/Evaluations/Evaluative KW - Social worker/Social workers KW - article KW - 2148: social problems and social welfare; applied sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60848850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work&rft.atitle=Help+for+the+Dying&rft.au=Pilsecker%2C+Carleton&rft.aulast=Pilsecker&rft.aufirst=Carleton&rft.date=1975-05-01&rft.volume=20&rft.issue=3&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Social+Work&rft.issn=00378046&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SOWOA8 N1 - SubjectsTermNotLitGenreText - Death/Deaths (see also Mortality, Dying); Social worker/Social workers; Role/Roles; Evaluation/Evaluations/Evaluative ER - TY - JOUR T1 - Determinants of Marital Happiness and Unhappiness Rated by Alcoholics and Their Wives AN - 60837026; 78J5564 AB - To determine the relative importance of variables contributing to marital happiness, white, M alcoholics (N=99), ages thirty-two to fifty-eight, in the Tuscaloosa Veterans Administration Hospital & their wives (ages thirty to fifty-nine) were interviewed. Rs rated the importance to their marriage of thirty-four happiness & forty-six unhappiness items. Space was allowed for Rs to add original items. Factor analysis ranked "undesirable vices (excessive gambling, drinking, etc)" first as contributing to marital unhappiness while their absence was ranked 27.5 by the husbands & 9.5 by the wives as contributing to marital happiness. Elimination of undesirable habits may resolve much marital misery, but it does not necessarily follow that as unhappiness decreases happiness will increase. The data also reveal that both husbands & wives generally agreed that the quality of interpersonal relations determined marital happiness. Consequently, the happiness/unhappiness model must be expanded to include indifference or neutrality. As the sources of unhappiness are removed, spouses may feel neutral, achieving happiness only when the interpersonal relationship actually improves. 2 Tables. Modified HA. JF - Journal of Studies on Alcohol AU - Wadsworth, Allen P, Jr AU - Wilson, Warner AU - Barker, Harry R, Jr AD - Veterans Administration Hospital, Tuscaloosa AL 3540l, Wright State U, Dayton OH 45431 & U Alabama, Tuscaloosa 35401 Y1 - 1975/05// PY - 1975 DA - May 1975 SP - 634 EP - 644 VL - 36 IS - 5 SN - 0096-882X, 0096-882X KW - alcoholics, spouses, marital happiness determinants KW - undesirable vices, interpersonal relations quality, indifference, neutrality KW - Drinking/Drinkers KW - Social relations/Social relationships KW - Marriage/Marriages/Marital KW - Relations, marriage KW - Alcoholic/Alcoholics/Alcoholism KW - Happiness KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60837026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Determinants+of+Marital+Happiness+and+Unhappiness+Rated+by+Alcoholics+and+Their+Wives&rft.au=Wadsworth%2C+Allen+P%2C+Jr%3BWilson%2C+Warner%3BBarker%2C+Harry+R%2C+Jr&rft.aulast=Wadsworth&rft.aufirst=Allen&rft.date=1975-05-01&rft.volume=36&rft.issue=5&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Marriage/Marriages/Marital; Relations, marriage; Alcoholic/Alcoholics/Alcoholism; Happiness; Drinking/Drinkers; Social relations/Social relationships ER - TY - JOUR T1 - Use of the Carrier Phrase in Live Voice Speech Discrimination Testing AN - 85441001; 7904499 AB - The effects of carrier phrase use in live voice discrimination testing was evaluated on 50 Ms (aged twenty-one to sixty-six) with sensorineural hearing loss. Ss were presented with four 50-word PB lists; the lists, ears, & the condition of with or without carrier were varied across Ss. Instructions were standardized & responses were oral. DSs were significantly higher when the carrier phrase was included; its advantage was related to pure-tone audiometric contour & to degree of hearing loss, though not significantly to the latter. DSs were higher for the second half-list than for the first half-list; SDs were larger for the second half-list. It was concluded that carrier phrases should be used whenever speech discrimination is tested by monitored live voice. 2 Tables. Modified HA JF - The Journal of Auditory Research AU - Gelfand, Stanley A AD - Veterans Administration Hospital, East Orange NJ 07019 Y1 - 1975/04// PY - 1975 DA - April 1975 SP - 107 EP - 110 VL - 15 IS - 2 KW - live voice discrimination testing KW - carrier phrase use KW - sensorineural hearing loss adults KW - Phonetically Balanced Lists (ph8) KW - Tone (to1) KW - Hearing Disorders (he3a) KW - Audiology (au2) KW - Audiometry (au3) KW - Testing (te7) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85441001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Auditory+Research&rft.atitle=Use+of+the+Carrier+Phrase+in+Live+Voice+Speech+Discrimination+Testing&rft.au=Gelfand%2C+Stanley+A&rft.aulast=Gelfand&rft.aufirst=Stanley&rft.date=1975-04-01&rft.volume=15&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Auditory+Research&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAURAE N1 - SubjectsTermNotLitGenreText - Hearing Disorders (he3a); Phonetically Balanced Lists (ph8); Tone (to1); Audiometry (au3); Testing (te7); Audiology (au2) ER - TY - JOUR T1 - A Structured Approach Teaching Aphasics Basic Sentence Types AN - 85433414; 7901317 AB - This study investigated a structured approach teaching three basic sentence types to adult aphasics. The three types - V form to be, V intransitive, & V - are used in applied linguistics & transformational grammar material in teaching English as a second language to adults. Ss were 4 adult Ms selected on the basis of good verbal output & auditory input scores measured by the PICA. Ss were given pre- & posttest measures of verbal syntactic performance for the three basic sentence types. They participated in a one-month therapy program which presented the three sentence types. All improved in posttest production of each basic sentence type, & in pattern carry-over & subject-V agreement. This type of therapeutic approach is suggested as part of a programmed lang rehabilitation program. The primary aim would be to set up realistic short-term language rehabilitation programs. It is hoped that a more detailed program will be developed, which could be used by a paraprofessional or even a family member. 2 Tables, 2 Figures. Modified HA JF - The British Journal of Disorders of Communication AU - Naeser, Margaret A AD - Veterans Administration Hospital, Palo Alto CA 94304 Y1 - 1975/04// PY - 1975 DA - April 1975 SP - 70 EP - 76 VL - 10 IS - 1 SN - 0007-098X, 0007-098X KW - language therapy structured approach, teaching basic sentence types KW - adult aphasics KW - Language Therapy (la7a) KW - Applied Linguistics (ap2) KW - Sentence (se13) KW - Aphasia (ap1) KW - Programmed Instruction (pr5) KW - Verbal (ve1) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85433414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Disorders+of+Communication&rft.atitle=A+Structured+Approach+Teaching+Aphasics+Basic+Sentence+Types&rft.au=Naeser%2C+Margaret+A&rft.aulast=Naeser&rft.aufirst=Margaret&rft.date=1975-04-01&rft.volume=10&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Disorders+of+Communication&rft.issn=0007098X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJDCBU N1 - SubjectsTermNotLitGenreText - Aphasia (ap1); Sentence (se13); Language Therapy (la7a); Applied Linguistics (ap2); Verbal (ve1); Programmed Instruction (pr5) ER - TY - JOUR T1 - The Domestic Relations Offender AN - 60070778; 77I3921 AB - Report on a comparative analysis of domestic relations offenders & other prisoners in a minimum-security prison is given. As compared with other prisoners, those who also had domestic relations convictions or charges were older, more likely to be either married or divorced, & passive in using services; they had been less violent in their criminal offenses, were more likely to have served in the military & to have received a less than honorable discharge, were more likely to have been working at the time of incarceration, & were more likely to have low job skills. Both corrections & public welfare agencies appear to deal unsuccessfully with the domestic offender. At the level of practice, domestic offenders should be identified & helped. At the policy level, integration of planning by corrections & public welfare agencies is necessary. 3 Tables. AA. JF - Social Service Review AU - Chaiklin, Harris AU - Kelly, Gerard R AD - U Maryland School Social Work, Baltimore 21201 & Veterans Administration Hospital, Perry Point MD Y1 - 1975/03// PY - 1975 DA - March 1975 SP - 115 EP - 121 VL - 49 IS - 1 SN - 0037-7961, 0037-7961 KW - domestic relations offenders KW - other prisoners KW - comparative analysis KW - practice, policy KW - Policy/Policies KW - Domestic/Domestics/Domestication/ Domesticated KW - Comparison/Comparisons/Comparative/Comparability KW - Offender/Offenders KW - Analysis/Analyses/Analyzing KW - Prison/Prisons/Prisoner/ Prisoners KW - article KW - 1653: social control; police, penology, & correctional problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60070778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Service+Review&rft.atitle=The+Domestic+Relations+Offender&rft.au=Chaiklin%2C+Harris%3BKelly%2C+Gerard+R&rft.aulast=Chaiklin&rft.aufirst=Harris&rft.date=1975-03-01&rft.volume=49&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Social+Service+Review&rft.issn=00377961&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - SSRVAW N1 - SubjectsTermNotLitGenreText - Domestic/Domestics/Domestication/ Domesticated; Offender/Offenders; Prison/Prisons/Prisoner/ Prisoners; Comparison/Comparisons/Comparative/Comparability; Analysis/Analyses/Analyzing; Policy/Policies ER - TY - JOUR T1 - Acquisition of Verbal Associations to Olfactory Stimuli of Varying Familiarity and to Abstract Visual Stimuli AN - 57985638; 7601046 AB - 2 paired-associate (PA) learning studies were conducted to observe acquisition performance of 85 college students using either odors or abstract figures as stimuli & numbers as responses. In both studies visual PA acquisition was reliably superior to olfactory learning. The 2nd study, designed to maximize association learning to odors & minimize association to figures learning demonstrated that the sense of smell is not as well suited to the PA task as vision when naive Ss are involved. In a 3rd experiment (N=60), familiarity of odors & figures was judged & reported as a graphic magnitude estimation response. These judged stimulus familiarities were used to select stimuli for the PA tasks. Subsequently, PA acquisition was facilitated by employing highly familiar odors. HA JF - Journal of Experimental Psychology: Human Learning and Memory AU - Davis, Richard G AD - Psychology Service Veterans Administration Hosp, 13000 North 30th St Tampa FL 33612 Y1 - 1975/03// PY - 1975 DA - March 1975 SP - 134 EP - 142 VL - 1 IS - 2 KW - paired-associate learning, verbal acquisition using olfactory vs. abstract visual stimuli KW - stimulus familiarity KW - Familiarity (fa1) KW - Psycholinguistics (ps3) KW - Paired Associate Learning (pa1) KW - Memory (me3) KW - Verbal Learning (ve2) KW - Visual Stimulation (vi2) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57985638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Psychology%3A+Human+Learning+and+Memory&rft.atitle=Acquisition+of+Verbal+Associations+to+Olfactory+Stimuli+of+Varying+Familiarity+and+to+Abstract+Visual+Stimuli&rft.au=Davis%2C+Richard+G&rft.aulast=Davis&rft.aufirst=Richard&rft.date=1975-03-01&rft.volume=1&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Psychology%3A+Human+Learning+and+Memory&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPHMD8 N1 - SubjectsTermNotLitGenreText - Psycholinguistics (ps3); Paired Associate Learning (pa1); Memory (me3); Verbal Learning (ve2); Visual Stimulation (vi2); Familiarity (fa1) ER - TY - JOUR T1 - Auditory Versus Audio-Visual Intelligibility Measurements of Alaryngeal Speech: A Preliminary Report AN - 58084059; 7901286 AB - Four M laryngectomized patients who were capable of producing esophageal speech each read a standardized passage aloud & were recorded on tape & film. Judges of the speech were 32 U students. Judgments were based on either auditory or audio-visual presentations. Judges used a seven-point scale to rate the overall intelligibility of the speech. They also answered multiple-choice questions about the content of the passage they heard. It was found that audio-visual presentation yielded a relative increase in rated intelligibility in contrast to the same speech presented auditorily. It is suggested that realistic therapeutic goals for an esophageal speaker should include the audio-visual component in clinical assessment. Modified HA JF - Perceptual and Motor Skills AU - Berry, Robert A AU - Knight, Robert E AD - Veterans Administration Hospital, Salem VA 24153 & U South Carolina, Columbia 29208 Y1 - 1975/01// PY - 1975 DA - January 1975 SP - 915 EP - 918 VL - 40 IS - 3 SN - 0031-5125, 0031-5125 KW - auditory vs audio-visual intelligibility measures, esophageal speech KW - undergraduates KW - Intelligibility (in11) KW - Eskimo/Aleut (es1) KW - Language Pathology (la4) KW - Laryngectomy (la11) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58084059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+Motor+Skills&rft.atitle=Auditory+Versus+Audio-Visual+Intelligibility+Measurements+of+Alaryngeal+Speech%3A+A+Preliminary+Report&rft.au=Berry%2C+Robert+A%3BKnight%2C+Robert+E&rft.aulast=Berry&rft.aufirst=Robert&rft.date=1975-01-01&rft.volume=40&rft.issue=3&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+Motor+Skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PMOSAZ N1 - SubjectsTermNotLitGenreText - Eskimo/Aleut (es1); Intelligibility (in11); Language Pathology (la4); Laryngectomy (la11) ER - TY - JOUR T1 - Religious Conviction and Fear of Death among the Healthy and the Terminally Ill AN - 60909998; 75H4727 AB - The focus is on the relationship between religious persuasion & fear of death in physically healthy persons & terminally ill patients. The sample is composed of 95 health S's & 92 terminally ill. The general characteristics of the religious & nonreligious groups in physically healthy & terminally ill S's are indicated on 9 demographic variables, & differences between groups (religious/nonreligious, healthy/terminally ill) are correlated with variables of conscious imagery, & below-level-of awareness measures concerning fear of death. No differences in the intensity of fear of death were found between believers & unbelievers. Personal nearness to death also did not reveal any meaningful differences between believers & nonbelievers. What did emerge was a pattern highpointing an ambivalent acceptance/avoidance approach toward fear of death. 2 Tables. Modified HA. JF - Journal for the Scientific Study of Religion AU - Feifel, Herman AD - Outpatient Clinic Veterans Administration, Los Angeles CA 90052 Y1 - 1974/09// PY - 1974 DA - September 1974 SP - 353 EP - 360 VL - 13 IS - 3 SN - 0021-8294, 0021-8294 KW - fear of death KW - religious persuasion KW - healthy vs terminally ill patients KW - Death/Deaths (see also Mortality, Dying) KW - Fear/Fears KW - Religion/Religions/Religious KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60909998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+for+the+Scientific+Study+of+Religion&rft.atitle=Religious+Conviction+and+Fear+of+Death+among+the+Healthy+and+the+Terminally+Ill&rft.au=Feifel%2C+Herman&rft.aulast=Feifel&rft.aufirst=Herman&rft.date=1974-09-01&rft.volume=13&rft.issue=3&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+for+the+Scientific+Study+of+Religion&rft.issn=00218294&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSSRBT N1 - SubjectsTermNotLitGenreText - Death/Deaths (see also Mortality, Dying); Religion/Religions/Religious; Fear/Fears ER - TY - JOUR T1 - Nursing Automony and Patients' Rights: Development of a Nursing Attitude Scale AN - 60865419; 75H6301 AB - A 69-item attitude scale was administered to 702 nurses in psychiatric hospitals, U hospitals, 2 community hospitals, & those representing nursing autonomy & patient's rights. A principal components factor analysis results in 3 subscales that adequately represented the intent: (1) nursing autonomy & advocacy, (2) patient's rights, & (3) rejection of traditional rule limitations. Higher scores were associated with education, leadership, academic setting, & nontraditional social climate. 2 Tables, 1 Figure. Modified HA. JF - Journal of Health and Social Behavior AU - Pankratz, Loren AU - Pankratz, Deanna AD - Veterans Administration Hospital, Portland OR 97207 & A. E. Brim Associates Ltd, 137 NE 102nd Ave Portland OR 97220 Y1 - 1974/09// PY - 1974 DA - September 1974 SP - 211 EP - 216 VL - 15 IS - 3 SN - 0022-1465, 0022-1465 KW - attitude scale on nursing autonomy & patient's rights KW - Patient/Patients KW - Attitude/Attitudes/Attitudinal KW - Autonomous/Autonomy KW - Nurse/Nurses/Nursing KW - Right/Rights KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60865419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+and+Social+Behavior&rft.atitle=Nursing+Automony+and+Patients%27+Rights%3A+Development+of+a+Nursing+Attitude+Scale&rft.au=Pankratz%2C+Loren%3BPankratz%2C+Deanna&rft.aulast=Pankratz&rft.aufirst=Loren&rft.date=1974-09-01&rft.volume=15&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+and+Social+Behavior&rft.issn=00221465&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JHSBA5 N1 - SubjectsTermNotLitGenreText - Attitude/Attitudes/Attitudinal; Autonomous/Autonomy; Nurse/Nurses/Nursing; Patient/Patients; Right/Rights ER - TY - JOUR T1 - Canine Aortofemoral Bypass: a New Technique for the Evaluation of Prosthetic Implants AN - 20072615; 10097684 JF - Angiology AU - Miller, Thomas A AU - Lindenauer, SMartin AU - Gleich, WPaul AD - Department of Surgery, Section of General Surgery, University of Michigan Medical Center and Veterans Administration Hospital, Ann Arbor, Michigan Y1 - 1974/09// PY - 1974 DA - Sep 1974 SP - 557 EP - 560 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 25 IS - 9 SN - 0003-3197, 0003-3197 KW - Biotechnology and Bioengineering Abstracts KW - Prosthetics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20072615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Canine+Aortofemoral+Bypass%3A+a+New+Technique+for+the+Evaluation+of+Prosthetic+Implants&rft.au=Miller%2C+Thomas+A%3BLindenauer%2C+SMartin%3BGleich%2C+WPaul&rft.aulast=Miller&rft.aufirst=Thomas&rft.date=1974-09-01&rft.volume=25&rft.issue=9&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331977402500901 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Prosthetics DO - http://dx.doi.org/10.1177/000331977402500901 ER - TY - JOUR T1 - LIFE HISTORY CORRELATES OF MINISTERIAL SUCCESS AN - 60864219; 76I2224 AB - LIFE HISTORY OR BIODATA CORRELATES OF MINISTERIAL SUCCESS WERE INVESTIGATED FOR A GROUP OF 92 SEVENTH-DAY ADVENTIST MINISTERS. THE CRITERION DATA REFLECTED THEIR CURRENT LEVEL OF SUCCESS & THE PREDICTORS REFLECTED THEIR STATUS AS SEMINARIANS BETWEEN THE YEARS 1940-50. 2 SIGNIFICANT BIVARIATE CORRELATIONS INDICATED THAT SUCCESSFUL MINISTERS CHOSE THEIR CAREER LATER THAN LESS SUCCESSFUL ONES & THAT EARNING COLL EXPENSES WAS PREDICTIVE OF SUCCESS. A STEPWISE REGRESSION PROCESS WAS USED TO DEVELOP A WEIGHTED PREDICTION MODEL, BUT THE MODEL DID NOT HOLD WHEN CROSS-VALIDATED. HA. JF - Journal of Vocational Behavior AU - Umeda, John K AU - Frey, David H AD - VETERANS ADMINISTRATION HOSPITAL, LOS ANGELES CA 90012 & CALIFORNIA STATE U, HAYWARD 94542 Y1 - 1974/06// PY - 1974 DA - June 1974 SP - 319 EP - 324 VL - 4 IS - 3 SN - 0001-8791, 0001-8791 KW - LIFE HISTORY & MINISTERIAL SUCCESS KW - Minister/Ministers/Ministerial KW - Life history KW - Success/Successes KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60864219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vocational+Behavior&rft.atitle=LIFE+HISTORY+CORRELATES+OF+MINISTERIAL+SUCCESS&rft.au=Umeda%2C+John+K%3BFrey%2C+David+H&rft.aulast=Umeda&rft.aufirst=John&rft.date=1974-06-01&rft.volume=4&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vocational+Behavior&rft.issn=00018791&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JVBHA2 N1 - SubjectsTermNotLitGenreText - Minister/Ministers/Ministerial; Success/Successes; Life history ER - TY - JOUR T1 - The effects of chlordiazepoxide, amphetamine and cocaine on bar-press behavior in normal and genetically nervous dogs. AN - 82760601; 17894105 AB - Studies on two strains of pointer dogs have demonstrated that administration of a benzodiazepine (chlordiazepoxide) facilitates acquisition of goal-directed behavior in "genetically nervous" subjects. Continued admistration of the drug is required to maintain barpress response in this strain of dogs. The concomitant administration of either cocaine or amphetamine, compounds which inhibit neuronal reuptake of norepinephrine, disrupts the behavioral response of the genetically nervous E-strain subjects to a far greater extent than the stable A-strain subjects. It is also shown that after 14 days of daily administration of chlordiazepoxide, withdrawal of the drug not only re-results in almost complete loss of bar-press response in the E-strain subjects but also results in a temporary decrease in the acquired behavioral response of the stable A-strain subjects. JF - Diseases of the nervous system AU - Angel, C AU - Murphree, O D AU - DeLuca, D C AD - Neuropsychiatric Research Laboratory, Veterans Administration Hospital, North Little Rock, Arkansas 72114, USA. Y1 - 1974/05// PY - 1974 DA - May 1974 SP - 220 EP - 223 VL - 35 IS - 5 SN - 0012-3714, 0012-3714 KW - Anti-Anxiety Agents KW - 0 KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Amphetamine KW - CK833KGX7E KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Drug Administration Schedule KW - Dogs KW - Behavior, Animal -- drug effects KW - Anti-Anxiety Agents -- pharmacology KW - Chlordiazepoxide -- pharmacology KW - Anxiety -- psychology KW - Anti-Anxiety Agents -- administration & dosage KW - Conditioning (Psychology) KW - Anxiety -- genetics KW - Cocaine -- pharmacology KW - Chlordiazepoxide -- administration & dosage KW - Amphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/82760601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diseases+of+the+nervous+system&rft.atitle=The+effects+of+chlordiazepoxide%2C+amphetamine+and+cocaine+on+bar-press+behavior+in+normal+and+genetically+nervous+dogs.&rft.au=Angel%2C+C%3BMurphree%2C+O+D%3BDeLuca%2C+D+C&rft.aulast=Angel&rft.aufirst=C&rft.date=1974-05-01&rft.volume=35&rft.issue=5&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Diseases+of+the+nervous+system&rft.issn=00123714&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-10 N1 - Date created - 2007-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Center Frequencies of 1/3-Octave Noise Bands on Intensity-Produced Lateralization Shifts AN - 85498075; 7803130 AB - This study on 3 normal hearing adults investigates the effect of center band of 1/3-octave noise bands on detectability of intensity produced lateralization shifts. A dichotic auditory noise image was centered with a differential attenuator, set at about 40 dB in regard to S's threshold, at center fs of .5, 1, 2, 4, & 8 kilocycles/second. The noise was shaped by a Krohn-Hite Model 310-AB band pass filter. Such lateralization shifts were more detectable at higher fs. This is the reverse of the case with pure tones, but similar to the trend of Mills for threshold of detection of a dichotic intensity-difference threshold. Modified HA JF - The Journal of Auditory Research AU - De l'Aune, William AU - Elfner, Lloyd AD - Eastern Blind Rehabilitation Ctr, Veterans Administration Hospital, W Haven CT 06516 & Florida State U, Tallahassee 32306 Y1 - 1974/04// PY - 1974 DA - April 1974 SP - 155 EP - 156 VL - 14 IS - 2 KW - center frequencies of 1/3 octave noise bands effects, intensity-produced lateralization shifts KW - Auditory Stimulation (au7) KW - Binaural Stimulation (bi2) KW - Intensity of Vibration (in12) KW - Frequency of Vibration (fr3) KW - Noise (no1) KW - Auditory Thresholds (au8) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85498075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Auditory+Research&rft.atitle=Effects+of+Center+Frequencies+of+1%2F3-Octave+Noise+Bands+on+Intensity-Produced+Lateralization+Shifts&rft.au=De+l%27Aune%2C+William%3BElfner%2C+Lloyd&rft.aulast=De+l%27Aune&rft.aufirst=William&rft.date=1974-04-01&rft.volume=14&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Auditory+Research&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAURAE N1 - SubjectsTermNotLitGenreText - Noise (no1); Frequency of Vibration (fr3); Intensity of Vibration (in12); Binaural Stimulation (bi2); Auditory Stimulation (au7); Auditory Thresholds (au8) ER - TY - JOUR T1 - Monaural and Binaural Signal Detection of Pure Tones AN - 58082586; 7803131 AB - Examined are auditory stimuli. The data relates to the single-channel model of central factors involved with auditory frequency selectivity vs the multiband model. Six Ss were trained in the use of rating scales & the two-interval forced-choice paradigm with feedback. Earphones in a soundproof room presented a pure tone of 710 cycles/second (c/s) to the left ear &/or one of 500 c/s to the right ear. A light of .2 second was on, then two successive lights of one second each indicating the experimental intervals, then a veridical feedback light. Inter-trial period was one second. The data indicate that no binaural summation occurs at low signal levels for these fs in the signal-known condition & that the single-channel model of attention proposed by O. Franzen, J. Markowitz, & J. Swets ("Spatially-Limited Attention to Vibrotactile Stimulation," Perceptual Psychophysiology, 1970, 7, 193-196.) could explain the results. J. Atkinson JF - The Journal of Auditory Research AU - De l'Aune, William AU - Elfner, Lloyd AU - Franzen, Ove AD - Eastern Blind Rehabilitation Ctr, Veterans Administration Hospital, W Haven CT 06516, Florida State U, Tallahassee 32306, & Karolinska Hospital, Stockholm Sweden Y1 - 1974/04// PY - 1974 DA - April 1974 SP - 121 EP - 123 VL - 14 IS - 2 KW - monaural vs binaural pure tone signal detection KW - Signal Detection (si2) KW - Rating Scale (ra2) KW - Tone (to1) KW - Auditory Stimulation (au7) KW - Monaural Stimulation (mo3) KW - Binaural Stimulation (bi2) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58082586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Auditory+Research&rft.atitle=Monaural+and+Binaural+Signal+Detection+of+Pure+Tones&rft.au=De+l%27Aune%2C+William%3BElfner%2C+Lloyd%3BFranzen%2C+Ove&rft.aulast=De+l%27Aune&rft.aufirst=William&rft.date=1974-04-01&rft.volume=14&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Auditory+Research&rft.issn=&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAURAE N1 - SubjectsTermNotLitGenreText - Auditory Stimulation (au7); Monaural Stimulation (mo3); Binaural Stimulation (bi2); Tone (to1); Rating Scale (ra2); Signal Detection (si2) ER - TY - JOUR T1 - Attitudes of Hospital Staff Toward Alcoholics and Drug Addicts AN - 60916271; 75H4367 AB - A survey was undertaken to determine the attitudes of hospital staff toward alcoholics & drug addicts. It was hypothesized that the staff involved in therapeutic care of the patients would have more favorable attitudes than the staff that was not so involved. 82 staff members of the Washingtonian Center for Addictions, grouped according to the status level of their positions, completed a questionnaire derived from the Gough Adjective Check List, choosing from 34 adjectives with positive & negative connotations as they apply to alcoholics & drug addicts. The sample consisted of 33 Ls (eg clerical), 30 Ms (nurses), & 19 Hs (psychiatrists) personnel. The Hs group was the most negative in their attitudes toward alcoholics & drug addicts & the Ls group had the least negative views. Staff members as a whole had more favorable attitudes toward alcoholics than drug addicts. Persons lower in education & status may experience less SD from alcoholics & drug addicts & therefore may hold less negative attitudes toward these groups. The negative views by the Hs may be because of the SD between the therapist & patient, or because some of the adjectives are part of the professional language used to describe the addictive personality. 1 Table. Modified HA. JF - Quarterly Journal of Studies on Alcohol AU - Sowa, Patricia A AU - Cutter, Henry S AD - Washington Center for Addictions, 41 Morton St Boston MA 02130 & Veterans Administration Hospital, Brockton MA 02403 Y1 - 1974/03// PY - 1974 DA - March 1974 SP - Mar, 210 EP - 214 VL - 35 IS - 1 KW - hospital staff attitudes towards alcoholics & drug addicts KW - Attitude/Attitudes/Attitudinal KW - Drug addict/Drug addicts/Drug addiction (see also Addict) KW - Alcoholic/Alcoholics/Alcoholism KW - Hospital/Hospitals KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60916271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quarterly+Journal+of+Studies+on+Alcohol&rft.atitle=Attitudes+of+Hospital+Staff+Toward+Alcoholics+and+Drug+Addicts&rft.au=Sowa%2C+Patricia+A%3BCutter%2C+Henry+S&rft.aulast=Sowa&rft.aufirst=Patricia&rft.date=1974-03-01&rft.volume=35&rft.issue=1&rft.spage=Mar&rft.isbn=&rft.btitle=&rft.title=Quarterly+Journal+of+Studies+on+Alcohol&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - QJSOAX N1 - SubjectsTermNotLitGenreText - Alcoholic/Alcoholics/Alcoholism; Attitude/Attitudes/Attitudinal; Drug addict/Drug addicts/Drug addiction (see also Addict); Hospital/Hospitals ER - TY - JOUR T1 - Attitudes of Social Workers and Other Professional Groups Toward Alcoholism AN - 60877956; 75H3945 AB - The attitudes of 588 Veterans Administration social workers (282 women) toward alcoholism & treatment of alcoholics were surveyed by questionnaire. The questionnaire consisted of 2 sections: section A dealt with the definition of alcoholism & its causes, & section B consisted of multiple choice questions. Space was provided for personal comments. Alcoholism was defined as an escape mechanism by 68% of the social workers, as a symptom complex by 67%, a disease by 65%, & as a behavior problem by 60%. The chief causes of alcoholism were believed to be conflict over dependency (by 73%), excessive dependency (63%), & low tension tolerance (63%). Abstinence was considered the criterion of successful treatment by 74%. Alcoholics Anonymous & group psychotherapy were the preferred treatments (by 79 & 67%); hospitalization was supported even though 80% of the social workers felt that prognosis was poor. There was little difference in attitudes between sexes or between social workers in hospitals or outpatient clinics. In comparison with the social workers, fewer psychiatrists (35%) & psychologists (34%) defined alcoholism as a disease. The social workers were more willing to work full time with alcoholics (34%) than the psychiatrists (21%) & psychologists (19%); 25, 38 & 42%, respectively, opposed full time work. Social workers are more highly motivated to treat alcoholics & more consistent in their attitudes toward alcoholism than either psychologists or psychiatrists. 2 Tables. Modified HA. JF - Quarterly Journal of Studies on Alcohol AU - Knox, Wilma J AD - Veterans Administration Center, Biloxi MS 39531 Y1 - 1973/12// PY - 1973 DA - December 1973 SP - Dec, 1270 EP - 1278 VL - 34 IS - 4 KW - social workers' attitudes toward alcoholism KW - Attitude/Attitudes/Attitudinal KW - Alcoholic/Alcoholics/Alcoholism KW - Social worker/Social workers KW - article KW - 1020: social differentiation; sociology of occupations & professions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60877956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quarterly+Journal+of+Studies+on+Alcohol&rft.atitle=Attitudes+of+Social+Workers+and+Other+Professional+Groups+Toward+Alcoholism&rft.au=Knox%2C+Wilma+J&rft.aulast=Knox&rft.aufirst=Wilma&rft.date=1973-12-01&rft.volume=34&rft.issue=4&rft.spage=Dec&rft.isbn=&rft.btitle=&rft.title=Quarterly+Journal+of+Studies+on+Alcohol&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - QJSOAX N1 - SubjectsTermNotLitGenreText - Attitude/Attitudes/Attitudinal; Alcoholic/Alcoholics/Alcoholism; Social worker/Social workers ER - TY - JOUR T1 - DEFECTS IN PRODIGIOSIN FORMATION BY L-FORMS OF SERRATIA MARCESCENS AN - 19062266; 7406099 AB - AN L-FORM OF SERRATIA MARCESCENS HAS PREVIOUSLY BEEN SHOWN INCAPABLE OF PRODUCING THE RED PIGMENT, PRODIGIOSIN, CHARACTERISTIC OF THE PARENT BACTERIA. MUTANTS OF S. MARCESENS, UNABLE TO FORM ONE OR THE OTHER OF THE TWO PRODIGIOSIN PRECURSORS, 4-METHOXY-2,2'-BIPYRROLE-5-CARBOXALDEHYDE OR 2-METHYL-3-N-AMYLPYRROLE, WERE USED TO TEST THE NATURE OF THE L-FORM DEFECT. THE L-FORMS FAILED TO FORM SUFFICIENT AMOUNTS OF EITHER PRECURSOR TO BE DETECTED BY THE APPROPRIATE MUTANT, AND, WHEN FURNISHED THE PRECURSORS, FAILED TO COUPLE THEM TO FORM PRODIGIOSIN. (HOLOMAN-BATTELLE) JF - JOURNAL OF BACTERIOLOGY, VOL 116, NO 3, P 1343-1345, DECEMBER 1973. 2 TAB, 6 REF. AU - Potter, C S AU - Hubert, E G AU - Montgomerie, J Z AU - Kalmanson, G M AU - Guze, L B AD - VETERANS ADMINISTRATION HOSPITAL-WADSWORTH, LOS ANGELES, CALIF. RESEARCH AND MEDICAL SERVICE Y1 - 1973/12// PY - 1973 DA - Dec 1973 KW - Water Resources Abstracts KW - *PIGMENTS KW - *SEPARATION TECHNIQUES KW - *AEROBIC BACTERIA KW - CULTURES KW - METHODOLOGY KW - CHEMICAL ANALYSIS KW - ASSAY KW - *MUTANTS KW - *SERRATIA MARCESCENS KW - *PRODIGIOSIN KW - HETEROTROPHIC BACTERIA KW - CULTURE MEDIA KW - 4-METHOXY-2 2'-BIPYRROLE-5-CARBOXALDEHYDE KW - 2-METHYL-3-N-AMYLPYRROLE KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19062266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DEFECTS+IN+PRODIGIOSIN+FORMATION+BY+L-FORMS+OF+SERRATIA+MARCESCENS&rft.au=Potter%2C+C+S%3BHubert%2C+E+G%3BMontgomerie%2C+J+Z%3BKalmanson%2C+G+M%3BGuze%2C+L+B&rft.aulast=Potter&rft.aufirst=C&rft.date=1973-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - BIODEGRADATION OF OLEATES AN - 19053396; 7315127 AB - BECAUSE OF THE WIDE VARIETY OF MAN-MADE OLEATES BEING USED IN INDUSTRY, TESTS WERE CONDUCTED TO DETERMINE THE BIODEGRADABILITY OF A NUMBER OF COMMERCIAL COMPOUNDS. THE COMPOUNDS STUDIED WERE METAL OLEATES, GLYCOL OLEATES, GLYCERAOL OLEATES, BUTYL, MORPHOLINE, METHYL, TRIETHANOLAMINE OLEATES, AND METHYL HYDROXYOLEATE. PSEUDOMONAS AERUGINOSA CULTURES WERE PREPARED FOR THE TESTS BY GROWING ON NUTRIENT AGAR AND RESUSPENDING IN SALINE SOLUTION. THE INOCULUM WAS PLACED IN A FLASK CONTAINING MINERAL SALTS BASAL MEDIUM AND A SPECIFIED CONCENTRATION OF A PARTICULAR FATTY ACID SALT AS THE SOLE CARBON SOURCE. BIODEGRADABILITY WAS DETERMINED BY THE RATE OF GROWTH OF THE BACTERIA IN OLEATE MEDIUM AND IN A CONTROL MEDIUM. SODIUM OLEATE WHICH IS KNOWN TO BE BIODEGRADABLE SERVED AS A REFERENCE. THE RESULTS INDICATE THAT THE DEGREE AND RATE OF DEGRADATION OF OLEIC AND HYDROXYOLEIC ACIDS ARE AFFECTED BY PURITY OF THE SUBSTRATE, NUMBER OR POSITION OF OLEATE SUBSTITUENTS, PRESENCE OF METALLIC SUBSTANCES, AND CONCENTRATION OF THE SUBSTRATE. (LITTLE-BATTELLE) JF - JOURANL WATER POLLUTION CONTROL FEDERATION, VOL 45, NO 8, P 1671-1681, AUGUST 1973. 7 FIG, 2 TAB, 36 REF. AU - Williams, J AU - Bennett, E O AD - VETERANS ADMINISTRATION HOSPITAL, HOUSTON, TEX Y1 - 1973/08// PY - 1973 DA - Aug 1973 KW - Water Resources Abstracts KW - *MICROBIAL DEGRADATION KW - *CULTURES KW - *GROWTH RATES KW - PATH OF POLLUTANTS KW - CARBON KW - *PSEUDOMONAS AERUGINOSA KW - *OLEATES KW - BIODEGRADABILITY KW - SODIUM OLEATE C KW - MORPHOLINE OLEATE KW - COPPER OLEATE KW - MAGNESIUM OLEATE KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19053396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=BIODEGRADATION+OF+OLEATES&rft.au=Williams%2C+J%3BBennett%2C+E+O&rft.aulast=Williams&rft.aufirst=J&rft.date=1973-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - FATTY ACID COMPOSITION OF L-FORMS OF STREPTOCOCCUS FAECALIS CULTURED AT DIFFERENT OSMOLALITIES AN - 19081836; 7400622 AB - THE FATTY ACID COMPOSITION OF THE MEMBRANES OF THREE DIFFERENT PENICILLIN-PRODUCED L-FORMS OF STREPTOCOCCUS FAECALIS WAS DETERMINED: (1) A STABLE (NONREVERTING) L-FORM (T53) CULTURED IN BRAIN HEART INFUSION (BHI) WITH 0.5 M SUCROSE; (2) A STABLE L-FORM (T531) CULTURED IN BHI WITHOUT SUCROSE; AND (3) AN UNSTABLE L-FORM (T9) CULTURED IN BHI WITH 0.5 M SUCROSE AND 1,000 U OF PENICILLIN PER ML. L-FORMS WERE OBTAINED BY CENTRIFUGATION AND LYSED BY WASHING IN 1 MM TRIS (HYDROXYMETHYL) AMINOMETHANE-HYDROCHLORIDE BUFFER. THE PARENT S. FAECALIS WAS ALSO CULTURED IN BHI AND BHI CONTAINING 0.5 M SUCROSE, AND WASHED WITH BUFFER. THE FATTY ACID COMPOSITION OF L-FORMS OF S. FAECALIS CULTURED IN BHI WITHOUT SUCROSE (370 MOSMOL) HAD HIGHER C18:1 AND LOWER C18 THAN L-FORMS CULTURED IN THE SAME MEDIA WITH ADDED 0.5 M SUCROSE (950 MOSMOL) IN BOTH EXPONENTIAL AND STATIONARY CULTURES. IN THE STATIONARY PHASE OF GROWTH, C19 WAS REDUCED IN THE L-FORMS CULTURED WITHOUT SUCROSE. SIMILAR CHANGES WERE SEEN IN THE PARENT S. FAECALIS CULTURED IN THE TWO TYPES OF MEDIA. THESE CHANGES IN MEMBRANE FATTY ACIDS MAY RELATE TO OSMO-REGULATION OF THE L-FORMS. (HOLOMAN-BATTELLE) JF - JOURNAL OF BACTERIOLOGY, VOL 115, NO 1, P 73-75, JULY 1973. 1 TAB, 10 REF. AU - Montgomerie, J Z AU - Kalmanson, G M AU - Guze, L B AD - VETERANS ADMINISTRATION HOSPITAL-WADSWORTH, LOS ANGELES, CALIF. RESEARCH AND MEDICAL SERVICE Y1 - 1973/07// PY - 1973 DA - Jul 1973 KW - Water Resources Abstracts KW - *CULTURES KW - *POLLUTANT IDENTIFICATION KW - CYTOLOGICAL STUDIES KW - ORGANIC ACIDS KW - CHEMICAL ANALYSIS KW - AEROBIC BACTERIA KW - LIPIDS KW - *STREPTOCOCCUS FAECALIS KW - *FATTY ACIDS KW - *CHEMICAL COMPOSITION KW - *OSMOTIC PRESSURE KW - CHEMOTAXONOMY KW - FLAME IONIZATION GAS CHROMATOGRAPHY KW - CULTURE MEDIA KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19081836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=FATTY+ACID+COMPOSITION+OF+L-FORMS+OF+STREPTOCOCCUS+FAECALIS+CULTURED+AT+DIFFERENT+OSMOLALITIES&rft.au=Montgomerie%2C+J+Z%3BKalmanson%2C+G+M%3BGuze%2C+L+B&rft.aulast=Montgomerie&rft.aufirst=J&rft.date=1973-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Interactions between Alcoholics and Their Wives: A Descriptive Analysis of Verbal and Nonverbal Behavior AN - 60855184; 77I9695 AB - 4 volunteer couples, the husbands of which were alcoholic & about to receive treatment at the Veterans Administration Center, Jackson, Miss, were studied via videotaping of interaction sessions, & interviewing. Results show that wives looked at their husbands more when the discussion was related to drinking than when it was not, but the husbands tended to look more at their wives when the discussion was not related to drinking. Findings are discussed in light of current beliefs concerning wifely contributions to husbands' alcoholism via positive/negative reinforcement. Findings suggest implications for additional research concerning stimulus-response in the area of alcoholism. 1 Figure. Modified HA. JF - Quarterly Journal of Studies on Alcohol AU - Hersen, Michel AU - Miller, Peter M AU - Eisler, Richard M AD - Veterans Administration Center, Jackson MS 39216 & U Mississippi Medical Center, Jackson 39216 Y1 - 1973/06// PY - 1973 DA - June 1973 SP - Jun, 516 EP - 520 VL - 34 IS - 2 KW - alcoholics vs wives, interaction, descriptive analysis KW - verbal, nonverbal behavior, positive-negative reinforcement beliefs, findings, research implications KW - Wife/Wives KW - Alcoholic/Alcoholics/Alcoholism KW - Interaction/Interactions/ Interactional/ Interactionalist/ Interactionalism/ Interactive KW - Analysis/Analyses/Analyzing KW - Descriptive/Description/Descriptions KW - article KW - 1941: the family and socialization; sociology of the family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60855184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quarterly+Journal+of+Studies+on+Alcohol&rft.atitle=Interactions+between+Alcoholics+and+Their+Wives%3A+A+Descriptive+Analysis+of+Verbal+and+Nonverbal+Behavior&rft.au=Hersen%2C+Michel%3BMiller%2C+Peter+M%3BEisler%2C+Richard+M&rft.aulast=Hersen&rft.aufirst=Michel&rft.date=1973-06-01&rft.volume=34&rft.issue=2&rft.spage=Jun&rft.isbn=&rft.btitle=&rft.title=Quarterly+Journal+of+Studies+on+Alcohol&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - QJSOAX N1 - SubjectsTermNotLitGenreText - Alcoholic/Alcoholics/Alcoholism; Descriptive/Description/Descriptions; Analysis/Analyses/Analyzing; Interaction/Interactions/ Interactional/ Interactionalist/ Interactionalism/ Interactive; Wife/Wives ER - TY - JOUR T1 - OPTIMUM PROCEDURE FOR THE DETERMINATION OF SELENIUM IN BIOLOGICAL SPECIMENS USING SE-77M NEUTRON ACTIVATION AN - 19076418; 7312876 AB - AN OPTIMUM PROCEDURE IS OUTLINED FOR THE RAPID QUANTITATIVE DETERMINATION OF TRACE (GREATER THAN OR EQUAL TO 0.06 MICROGRAM) SELENIUM IN SERUM AND TISSUE USING SE-77M NEUTRON ACTIVATION. SAMPLE PREPARATION, IRRADIATION PROCEDURES, TYPES OF DETECTOR ASSEMBLIES, AND SPECTRAL ANALYSES AND DATA REDUCTION ARE DISCUSSED. THE OPTIMUM PROCEDURE TUILIZING A LOW-POWER NUCLEAR REACTOR CONSISTED OF IRRADIATING LYOPHILIZED TISSUE SAMPLES OR DIALYZED-LYOPHILIZED SERUM SAMPLES FOR 20 SEC, WITH A 20-SEC DECAY TIME PRIOR TO RADIOASSAY. THE MOST SUITABLE RADIOASSAY ASSEMBLY WAS THE 5-MM X 3-IN NAI (TL) DETECTOR SYSTEM. SPECTRAL ANALYSES AND DATA REDUCTION CONSISTED OF ELIMINATING THE INTERFERENCES OF ISOTOPES OF RELATIVELY LONG HALF-LIVES BY SPECTRUM SUBTRACTION AND CORRECTION. COMPARISONS BETWEEN THE RESULTS OBTAINED BY THE DISCUSSED SE-77M PROCEDURE AND VALUES QUOTED FOR AN NBS BOVINE LIVER STANDARD WERE EXCELLENT. (LITTLE-BATTELLE) JF - ANALYTICAL CHEMISTRY, VOL 45, NO 7, P 1056-1060, JUNE 1973. 5 FIG, 2 TAB, 14 REF. AU - BLOTCKY, A J AU - Arsenault, L J AU - Rack, E P AD - VETERANS ADMINISTRATION HOSPITAL, OMAHA, NEBR Y1 - 1973/06// PY - 1973 DA - Jun 1973 KW - Water Resources Abstracts KW - *NEUTRON ACTIVATION ANALYSIS KW - *DATA PROCESSING KW - RADIOACTIVITY TECHNIQUES KW - IRRADIATION KW - POLLUTANT IDENTIFICATION KW - *TISSUE KW - *BLOOD KW - *SELENIUM KW - BIOLOGICAL SAMPLES KW - SAMPLE PREPARATION KW - SE-77M KW - DETECTORS KW - DETECTION LIMITS KW - SW 0880:Chemical processes KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19076418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=OPTIMUM+PROCEDURE+FOR+THE+DETERMINATION+OF+SELENIUM+IN+BIOLOGICAL+SPECIMENS+USING+SE-77M+NEUTRON+ACTIVATION&rft.au=BLOTCKY%2C+A+J%3BArsenault%2C+L+J%3BRack%2C+E+P&rft.aulast=BLOTCKY&rft.aufirst=A&rft.date=1973-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - BACTERIAL IDENTIFICATION BY MICROCALORIMETRY AN - 19065924; 7310848 AB - SEVENTEEN SPECIES FROM 10 GENERA OF ENTERBACTERIACEAE WERE GROWN ON BRAIN-HEART INFUSION (BHI) MEDIUM AND ANALYZED BY MICROCALORIMETRY AS A MEANS OF DIFFERENTIATING SPECIES. THE PROFILES WERE RECORDED ON A STRIP CHART RECORDER FOR PERIODS UP TO 14 HRS. USING THE CURVES, IT WAS POSSIBLE TO DISCRIMINATE BETWEEN ALL THE SPECIES TESTED. PROFILES ARE INCLUDED FOR ENTEROBACTER AEROGENES, KLEBSIELLA, PROTEUS VULGARIS, ENTEROBACTER CLOACAE, ESCHERICHIA COLI, AND PROTEUS RETTGERI. STREPTOCOCCUS FAECALIS WAS ALSO AMONG THE BACTERIA INVESTIGATED. MICROCALORIMETRY PROMISES TO BE A RAPID AND SPECIFIC MEANS OF CHARACTERIZATION OF ENTEROBACTERIACEAE AND POSSIBLY OTHER BACTERIA. (LITTLE-BATTELLE) JF - NATURE, VOL 241, NO 5390, P 472-473, FEBRUARY 16, 1973. 1 FIG, 1 REF. AU - Boling, E A AU - Blanchard, G C AU - Russell, W J AD - VETERANS ADMINISTRATION HOSPITAL, BOSTON, MASS Y1 - 1973/02// PY - 1973 DA - Feb 1973 KW - Water Resources Abstracts KW - *POLLUTANT IDENTIFICATION KW - CULTURES KW - STREPTOCOCCUS KW - E. COLI KW - SPECIATION KW - SEPARATION TECHNIQUES KW - *MICROCALORIMETRY KW - ENTEROBACTER AEROGENES KW - KLEBSIELLA KW - PROTEUS VULGARIS KW - ENTEROBACTER CLOACAE KW - PROTEUS RETTGERI KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19065924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=BACTERIAL+IDENTIFICATION+BY+MICROCALORIMETRY&rft.au=Boling%2C+E+A%3BBlanchard%2C+G+C%3BRussell%2C+W+J&rft.aulast=Boling&rft.aufirst=E&rft.date=1973-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Evaluating Social Consequences of Erotic Films: An Experimental Approach AN - 60896303; 75H1389 AB - A methodological model for testing theoretical constructs & investigating pragmatic social problems simultaneously is described. Behavioral & attitudinal consequences of viewing erotic films are assessed in terms of cathartic, instigational, & social learning formulations. Comparative attitudinal & behavioral changes over a 12 week period are reported for 51 married couples who viewed erotic films, 17 couples who viewed nonerotic films, & 15 couples who viewed no films. All couples who viewed films completed 84 consecutive daily checklists of sexual & marital behavior. Couples viewing erotic films reported significantly more sexual activity on film viewing nights, & became more tolerant of legal exhibition of erotic films. No group exhibited significant stable changes in sexual behavior, & completing daily checklists appeared to facilitate sexual activity more than viewing erotic films. Results appear most concordant with social learning theory & fail to support the position that viewing erotic films produces harmful social consequences. 3 Tables. HA. JF - The Journal of Social Issues AU - Mann, Jay AU - Sidman, Jack AU - Starr, Sheldon AD - U California, San Francisco 94143, U California, Santa Cruz 95060 & Veterans Administration Hospital, Palo Alto CA 94302 Y1 - 1973///0, PY - 1973 DA - 0, 1973 SP - 113 EP - 131 VL - 29 IS - 3 SN - 0022-4537, 0022-4537 KW - sexual attitudinal & behavioral changes KW - viewing erotic films KW - married couples KW - Erotic/Eroticism KW - Consequence/Consequences KW - Social KW - Film/Films KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60896303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Social+Issues&rft.atitle=Evaluating+Social+Consequences+of+Erotic+Films%3A+An+Experimental+Approach&rft.au=Mann%2C+Jay%3BSidman%2C+Jack%3BStarr%2C+Sheldon&rft.aulast=Mann&rft.aufirst=Jay&rft.date=1973-01-01&rft.volume=29&rft.issue=3&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Social+Issues&rft.issn=00224537&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSISAF N1 - SubjectsTermNotLitGenreText - Erotic/Eroticism; Film/Films; Consequence/Consequences; Social ER - TY - JOUR T1 - EXPERIENTIAL RESEARCH: AN INSIDE PERSPECTIVE ON SUICIDE AND SOCIAL SYSTEMS AN - 60829511; 76I0684 AB - ADOPTING A SUICIDAL IDENTITY, A CLINICAL ANTHROPOLOGIST LIVED IN A PSYCHIATRIC HOSPITAL, & LATER, WITH A CLINICAL PSYCHOLOGIST, IN SEVERAL POSTHOSPITAL CARE FACILITIES FOR PERIODS FROM 2 WEEKS TO A MONTH IN EACH SETTING. THE RESEARCHERS WERE ABLE TO ESTABLISH IDENTITIES CLOSELY RESEMBLING THOSE OF GENUINELY SUICIDAL PERSONS. FROM THEIR EXPERIENTIAL ACCOUNTS & OBSERVATIONS OF SOCIAL SETTINGS, FROM HOSPITAL RECORDS & POSTTREATMENT MEETINGS WITH STAFF MEMBERS & FELLOW PATIENTS, CERTAIN CONCLUSIONS WERE INDICATED. PATIENTS' FEELINGS OF IMPOTENCE, UNIMPORTANCE & FUTURELESSNESS ARE OFTEN REINFORCED BY THE AMBIENCE OF PSYCHIATRIC FACILITIES, IN WHICH POWER SO OBVIOUSLY RESIDES IN THE STAFF. WITHDRAWAL, SUBVERSION OF STAFF GOALS, VIOLENT ACTIVITY OR NEW SUICIDE ATTEMPTS ARE AMONG THE CONSEQUENCES OF THIS CIRCUMSTANCE. IN VIEW OF MENTAL PATIENTS' GENERAL ACQUIESCENCE TO THE LARGER SOCIETY'S DISPARAGEMENT OF INSANITY, COMMUNICATION & PERSONAL ATTENTION BY STAFF MEMBERS TO & WITH PATIENTS IS ESSENTIAL TO THE RECONSTRUCTION OF THE LATTER'S SENSE OF SELF-WORTH. A PARTICULARLY DELICATE POINT IN THE LARGER BOARD & CARE HOMES OCCURS WHEN AN INCOMING PATIENT HAS LOST HIS STATUS AS A 'NEW-COMER' BUT STILL HAS NOT BEEN INTEGRATED INTO THE COMMUNITY OF THE FACILITY. SPECIAL EFFORT IS REQUIRED TO PREVENT THE PATIENT FROM FEELING CULTIVATED & THEN ABANDONED AS THIS CAN ONLY STRENGTHEN HIS FEELINGS OF WORTHLESSNESS. MODIFIED HA. JF - Life-Threatening Behavior AU - Reynolds, David K AU - Farberow, Norman L AD - VETERANS ADMINISTRATION CENTRAL RESEARCH UNIT, LOS ANGELES CA 90053 Y1 - 1973/01// PY - 1973 DA - January 1973 SP - 261 EP - 269 VL - 3 IS - 4 KW - SUICIDE RESEARCH IN POSTHOSPITAL CARE FACULTIES KW - Patient/Patients KW - Psychiatry/Psychiatric KW - Suicide/Suicides/Suicidal KW - Research/Researcher/Researchers KW - Social system/Social systems KW - Hospital/Hospitals KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60829511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life-Threatening+Behavior&rft.atitle=EXPERIENTIAL+RESEARCH%3A+AN+INSIDE+PERSPECTIVE+ON+SUICIDE+AND+SOCIAL+SYSTEMS&rft.au=Reynolds%2C+David+K%3BFarberow%2C+Norman+L&rft.aulast=Reynolds&rft.aufirst=David&rft.date=1973-01-01&rft.volume=3&rft.issue=4&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Life-Threatening+Behavior&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - LTBHAA N1 - SubjectsTermNotLitGenreText - Research/Researcher/Researchers; Social system/Social systems; Suicide/Suicides/Suicidal; Hospital/Hospitals; Psychiatry/Psychiatric; Patient/Patients ER - TY - JOUR T1 - Growth-promoting effects of silicon in rats. AN - 85244555; pmid-12635226 JF - Nature AU - Schwarz, K AU - Milne, D B AD - Laboratory of Experimental Metabolic Diseases, Veterans Administration Hospital, Long Beach, California 90801, USA. PY - 1972 SP - 333 EP - 334 VL - 239 IS - 5371 SN - 0028-0836, 0028-0836 KW - Rats KW - Growth KW - Rats, Inbred F344 KW - Silicon KW - Support, U.S. Gov't, P.H.S. KW - Animal KW - Diet KW - Time Factors KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85244555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Growth-promoting+effects+of+silicon+in+rats.&rft.au=Schwarz%2C+K%3BMilne%2C+D+B&rft.aulast=Schwarz&rft.aufirst=K&rft.date=1972-10-01&rft.volume=239&rft.issue=5371&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - SURVIVAL OF RANA PIPIENS IN DEIONIZED WATER AN - 19050703; 7306016 AB - THE ABILITY OF RANA PIPIENS TO SURVIVE IN DEIONIZED WATER WAS STUDIED IN ORDER TO DISPELL THE GENERALLY ACCEPTED VIEW THAT FROGS DIE WITHIN A FEW HOURS IF PLACED IN DISTILLED WATER DUE TO A RAPID LOSS OF SODIUM CHLORIDE VIA THEIR PERMEABLE SKIN AND INEFFICIENT SALT REABSORPTIVE MECHANISMS (VIA THE KIDNEY) TO AQUEOUS ENVIRONMENTS. A 1936 EXPERIMENT IN WHICH FROGS WERE SPRAYED WITH DISTILLED WATER AND SURVIVED FOR MORE THAN 3 TO 12 WEEKS AT ROOM TEMPERATURE IS CITED AS AN EXAMPLE OF HOW FROGS CAN SURVIVE FOR LONG PERIODS IN DEIONIZED WATER BY UTILIZING THEIR REMARKABLE POWER TO RETAIN SALTS AND THEIR MECHANISM FOR ABSORBING THE CHLORIDE ION THROUGH THE SKIN FROM DILUTE SOLUTIONS OF SODIUM CHLORIDE. ASHING EXPERIMENTS INDICATE THAT REGARDLESS OF THE PRIOR HISTORY OF THE FROG, MAINTENANCE FOR 30 TO 60 DAYS IN DEIONIZED WATER DOES NOT ALTER THE SODIUM ION CONTENT. ISOTOPE EXPERIMENTS SEEM TO INDICATE THAT SODIUM ION OUTFLUX IN LIVING FROGS ARE AT LEAST PARTIAL MEASUREMENTS OF AN EXCHANGE REACTION RATHER THAN OF NET SODIUM ION LOSS; CONSEQUENTLY, TRACER EXPERIMENTS ON LIVING FROGS MAY GIVE THE IMPRESSION THAT THE SKIN IS PERMEABLE TO SODIUM IONS WHEN IT IS NOT. WHATEVER THE REASON FOR THE MISCONCEPTION ABOUT A FROG'S ABILITY TO SURVIVE SALT-FREE WATER, IT IS CLEAR THAT FROGS DO NOT LOSE APPRECIABLE AMOUNTS OF SODIUM IONS TO DISTILLED OR DEIONIZED WATER AND ARE ABLE TO SURVIVE FOR MANY WEEKS. (BYRD-BATTELLE) JF - SCIENCE, VOL 178, NO 4057, P 183-185, OCTOBER 13, 1972. 11 REF. AU - McAfee, R D AD - VETERANS ADMINISTRATION HOSPITAL, NEW ORLEANS, LA Y1 - 1972/10// PY - 1972 DA - Oct 1972 KW - Water Resources Abstracts KW - *ENVIRONMENTAL EFFECTS KW - FROGS KW - AMPHIBIANS KW - ION TRANSPORT KW - AQUEOUS SOLUTIONS KW - MEMBRANE PROCESSES KW - OSMOSIS KW - RADIOACTIVITY TECHNIQUES KW - CHLORIDES KW - TAGGING KW - ANALYTICAL TECHNIQUES KW - *RANA PIPIENS KW - *OSMOREGULATION KW - SURVIVAL KW - *DEIONIZED WATER KW - SODIUM RADIOISOTOPES KW - ASHING KW - CHORDATES KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19050703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SURVIVAL+OF+RANA+PIPIENS+IN+DEIONIZED+WATER&rft.au=McAfee%2C+R+D&rft.aulast=McAfee&rft.aufirst=R&rft.date=1972-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - 'NORMAL' LEAD AND CADIUM CONTENT OF THE HUMAN KIDNEY AN - 19108226; 7412517 AB - CADMIUM AND LEAD HAVE BEEN SHOWN TO CAUSE HYPERTENSION, ACCELERATED ATHEROSCLEROSIS, KIDNEY DISEASE, AND NEOPLASIA IN EXPERIMENTAL ANIMALS. SINCE BOTH METALS ACCUMULATE IN THE KIDNEY, RENAL CONCENTRATIONS MAY REFLECT PROLONGED EXPOSURE. TO EVALUATE EFFECTS OF LONG-TERM MODERATE EXPOSURE, 'NORMAL' CONCENTRATION MUST FIRST BE ESTABLISHED IN MAN ON THE BASIS OF AUTOPSY STUDIES. INCREASED RENAL LEAD WAS NOT ASSOCIATED WITH HYPERTENSION OR NEOPLASIA, ALTHOUGH LONGEVITY WAS COMPROMISED AS A RESULT OF CLINICAL LEAD POISONING. RENAL CADMIUM HAS BEEN PREVIOUSLY SHOWN TO BE INCREASED IN MAN IN ASSOCIATION WITH NEOPLASIA AND EMPHYSEMA. (ROWE-VANDERBILT) JF - ARCHIVES OF ENVIRONMENTAL HEALTH, VOL 24, NO 6, P 364-368, JUNE, 1972. 4 TAB, 36 REF. AU - Morgan, J M AD - VETERANS ADMINISTRATION HOSPITAL, BIRMINGHAM, ALA. TRACE METALS LAB Y1 - 1972/06// PY - 1972 DA - Jun 1972 KW - Water Resources Abstracts KW - *LEAD KW - *CADMIUM KW - *HUMAN PATHOLOGY KW - *SPECTROSCOPY KW - ABSORPTION KW - DISTRIBUTION KW - AVERAGE KW - POLLUTANT IDENTIFICATION KW - *KIDNEY(HUMAN) KW - BACKGROUND LEVELS KW - HYPERTENSION KW - SW 3010:Identification of pollutants KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19108226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=%27NORMAL%27+LEAD+AND+CADIUM+CONTENT+OF+THE+HUMAN+KIDNEY&rft.au=Morgan%2C+J+M&rft.aulast=Morgan&rft.aufirst=J&rft.date=1972-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Bronchogenic cancer, sepsis and survival AN - 754561689; 13378320 AB - There is much speculation concerning the effect of post-operative sepsis (empyema) on the course of patients with bronchogenic carcinoma. Most reported series include only a few patients with short follow-up. This paper reports a series of over 900 cases of resectable bronchogenic carcinoma who have been followed carefully for five years. At each time interval reported, even excluding the 30-day mortality, the patients who did not experience infection had a better outlook. The differences are not statistically significant, and lend no support to the apparent increased survival associated with infection and bronchogenic carcinoma. JF - Journal of Surgical Oncology AU - Lawton, R L AU - Keehn, R J AD - Professor of Surgery, University of Iowa Hospitals; and Director, Renal Dialysis Center, Veterans Administration Hospital, Iowa City, Iowa 52240 PY - 1972 SP - 466 EP - 469 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 4 IS - 5-6 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Mortality KW - Sepsis KW - Statistical analysis KW - Survival KW - Empyema KW - Infection KW - Carcinoma KW - K 03400:Human Diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754561689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Bronchogenic+cancer%2C+sepsis+and+survival&rft.au=Lawton%2C+R+L%3BKeehn%2C+R+J&rft.aulast=Lawton&rft.aufirst=R&rft.date=1972-01-01&rft.volume=4&rft.issue=5-6&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930040510 L2 - http://www3.interscience.wiley.com/journal/112720619/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Mortality; Sepsis; Statistical analysis; Survival; Empyema; Infection; Carcinoma DO - http://dx.doi.org/10.1002/jso.2930040510 ER - TY - JOUR T1 - An Eight-Year Survey of Hospital Suicides AN - 60920110; 75H6735 AB - Information about suicide in hospitals of the Veterans Administration during the period 1959-66 is presented. Using rates computed on the basis of "patient treated," the overall suicide index is 16 per 100,000, a low figure considering the age & illness of the patients in the VA hospital population. General medical & surgical patients (GM&S) hospitals as a whole report a rate of approximately 6, while neuropsychiatric (NP) hospitals report a rate of 72. The typical NP suicide is in his 30's; the typical GM&S suicide is in his 40's. 75% of the NP suicides & 40% of the GM&S suicides kill themselves outside of the hospital. The methods of suicide vary partly as a function of availability. In the community, VA patients, as a general population, tend to use guns. In hospitals, jumping (GM&S) & hanging (NP) account for 75% of all suicides. Recommendations include: (1) treatment: exit interviewing of patient & family to assess the status of the patient, his readiness to leave the hospital, & the readiness of the environment to receive him; (2) physical: modification of present structures specifically designed to prevent jumping & hanging in hospitals; & (3) training: continuing desensitization procedures for staff to diminish taboos about suicide, death, & dying; regular orientation of staff towards suicide prevention procedures; & establishment of a standing suicide prevention committee for each hospital to oversee training & elimination of physical dangers. HA. JF - Life-Threatening Behavior AU - Farberow, Norman L AU - Ganzler, Sidney AU - Cutter, Fred AU - Reynolds, David AD - Central Research Unit Veterans Administration Center, Los Angeles CA 90053 Y1 - 1971/10// PY - 1971 DA - October 1971 SP - 184 EP - 202 VL - 1 IS - 3 KW - hospital suicides KW - Suicide/Suicides/Suicidal KW - Hospital/Hospitals KW - article KW - 2045: sociology of health and medicine; sociology of medicine (public health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60920110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life-Threatening+Behavior&rft.atitle=An+Eight-Year+Survey+of+Hospital+Suicides&rft.au=Farberow%2C+Norman+L%3BGanzler%2C+Sidney%3BCutter%2C+Fred%3BReynolds%2C+David&rft.aulast=Farberow&rft.aufirst=Norman&rft.date=1971-10-01&rft.volume=1&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Life-Threatening+Behavior&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - LTBHAA N1 - SubjectsTermNotLitGenreText - Suicide/Suicides/Suicidal; Hospital/Hospitals ER - TY - JOUR T1 - Suicide: The Wish, the Act, and the Outcome AN - 60866463; 75H5838 AB - Studies of suicide attempts need to distinguish between the differences in the wish to die, the act of self-injury & the terminal outcome for more effective prevention. A self-injury theory of suicidal phenomena is developed, based on the hypothesis that the individual is seeking a change in his awareness of an unacceptable deprivation. A prodromal table of signs of the suicide life cycle is presented in early, middle & late phases. These begin with bereavement before age 16, parental psychopathology, suicidal behavior or death, military, educational or work problems, marital problems, psychiatric treatment, alcohol or drug abuse, & self-defeating behavior. The middle stage includes accident, history, lack of cooperation in a prolonged medical illness, suicidal preoccupation or threats, depression, low intent self-injury, aimlessness, & ambivalence about personal suicide. The late stage is long term hospitalization, 5 or more low-intent self-injuries, 1 or more high-intent attempts, alienation from significant others, social or physical impairments, suicide as a right philosophy, & a marked dependency on institutions. A suicidal event can be analyzed in terms of the relation of this cycle to chance factors. A S's continuing view of self-consciousness can be analyzed to determine high levels of suicidal motivation, & watched until this level is reduced. A change of awareness based on perceived deprivation can determine how far along the self-injurious scale a person goes. The deprivations & the amount of injury become more intense with the criteria the individual holds. The starting point for this is the stereotyped expectations held by a certain group for a specific role. Early responses include rationalization, denial, or projection. Later responses are the distraction of drink, food, or drugs. A patient's intention, planning & method could be used to measure his wish-to-die status. 2 Tables. Modified HA. JF - Life-Threatening Behavior AU - Cutter, Fred AD - Central Research Unit Veterans Administration Center, Los Angeles CA 90053 Y1 - 1971/07// PY - 1971 DA - July 1971 SP - 125 EP - 137 VL - 1 IS - 2 KW - motivation & stages of suicide attempts KW - Motive/Motives/Motivation/ Motivational KW - Behavior/Behavioral KW - Suicide/Suicides/Suicidal KW - article KW - 0312: social psychology; personality & culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60866463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life-Threatening+Behavior&rft.atitle=Suicide%3A+The+Wish%2C+the+Act%2C+and+the+Outcome&rft.au=Cutter%2C+Fred&rft.aulast=Cutter&rft.aufirst=Fred&rft.date=1971-07-01&rft.volume=1&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Life-Threatening+Behavior&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - LTBHAA N1 - SubjectsTermNotLitGenreText - Suicide/Suicides/Suicidal; Behavior/Behavioral; Motive/Motives/Motivation/ Motivational ER - TY - CPAPER T1 - AGING AND ADJUSTMENT: THE APPLICABILITY OF LOGOTHERAPY AND THE PURPOSE-IN-LIFE SCALE T2 - Southwestern Sociological Association AN - 61728440; 71E8018 AB - Logotherapy, the creation of Viennese psychiatrist Viktor E. Frankl, is the first application of existential philosophy to mental health which has developed a technique. It aims at helping individuals to face crisis situations wherein a radical change in status has created a loss of personal identity & purpose in life. This it does by guidance in exploring all human values for fresh sources of meaning, & for a new perception of the relationship between the sum total of the individual's life experiences (or the Gestalten of his Lebenswelt) & this meaning. By this process it helps him to fill the existential vacuum (or lack of meaning & purpose, manifested primarily by boredom) which has followed his person loss. The Purposein-Life Test is an attitude scale designed to measure the degree to which one experiences this existential vacuum. It has successfully differentiated groups on the basis of many parameters which have been predicted to represent a change in the level of organization around meaningful life goals. The process of aging is one such parameter. The decline of physical & mental capacities, & particularly the stage of retirement, yield in most individuals an altered life style which loses or modifies the sense of meaning & purpose that has been the source of actualization & the mainspring of energy over many decades. New values must be explored for meanings which can fulfill the same identity or create a new one, while remaining within the realm of realization of the present organic function & cultural milieu. Otherwise the individual degenerates into the hopelessness & despair of existential vacuum. The Purpose-in-Life Scale has demonstrated potential for the evaluation of this condition, & the techniques of logotherapy for its alleviation. JF - Southwestern Sociological Association AU - Crumbaugh, James C Y1 - 1971///0, PY - 1971 DA - 0, 1971 KW - ADJUSTMENT : & AGING KW - AGING-AGED : & ADJUSTMENT KW - THERAPY : -LOGO, APPLICATION OF KW - Aging (see also Aged, Geriatric) KW - Therapy/Therapeutic KW - Adjustment/Adjustments KW - proceeding KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61728440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Southwestern+Sociological+Association&rft.atitle=AGING+AND+ADJUSTMENT%3A+THE+APPLICABILITY+OF+LOGOTHERAPY+AND+THE+PURPOSE-IN-LIFE+SCALE&rft.au=Crumbaugh%2C+James+C&rft.aulast=Crumbaugh&rft.aufirst=James&rft.date=1971-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Southwestern+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1971 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Reversal of Penicillin-Induced L-Phase Growth of Haemophilus influenzae by Spermine and Its Effects on Antibiotic Susceptibility. AN - 733476523; 16557761 AB - Spermine at a concentration of 0.001 m initiated the reversion of penicillin-induced L-phase growth of Haemophilus influenzae to bacillary growth on penicillin L-phase medium. Reversion of L-phase colonies to bacillary colonies required 3 to 5 days. This spermine reversal of variant growth also occurred on penicillin induction medium in the presence of concentrations of tetracycline, erythromycin, and chloramphenicol that were not bactericidal for L-phase or bacillary inocula until 48 or more hr. Spermine was without protective effect against streptomycin and kanamycin, which were, in combination with penicillin, bactericidal at 24 hr. Spermine protection of L-phase variants against antibiotic toxicity was, therefore, related to initiation (by spermine) or bacillary growth from round bodies that survived for 24 or more hr at bacteriostatic levels of antibiotic. JF - Infection and immunity AU - Lapinski, E M AU - Flakas, E D AD - Clinical Laboratory Service, Veterans Administration Hospital, and Department of Medical Microbiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53705. Y1 - 1970/05// PY - 1970 DA - May 1970 SP - 474 EP - 478 VL - 1 IS - 5 SN - 0019-9567, 0019-9567 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733476523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Reversal+of+Penicillin-Induced+L-Phase+Growth+of+Haemophilus+influenzae+by+Spermine+and+Its+Effects+on+Antibiotic+Susceptibility.&rft.au=Lapinski%2C+E+M%3BFlakas%2C+E+D&rft.aulast=Lapinski&rft.aufirst=E&rft.date=1970-05-01&rft.volume=1&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-29 N1 - Date created - 2010-06-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Rev. 1964 Sep;16:245-300 [14211123] Biochim Biophys Acta. 1967 Jul 18;142(2):440-9 [4861437] J Bacteriol. 1969 May;98(2):749-55 [5305776] Science. 1968 Jul 12;161(3837):164 [5657062] J Bacteriol. 1962 May;83(5):1101-11 [16561942] J Exp Med. 1952 Feb;95(2):191-208 [14907970] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Colostral leukocytes AN - 754562333; 13378156 AB - Leukocytes of human colostrum were studied for their phagocytic activity and ability to migrate in vitro. Samples were collected from healthy females in the first 2 weeks after delivery. Leukocytes were found with great regularity in concentrations of 2200-4100/mm3. These colostral leukocytes displayed glass adhesiveness, amoeboid movement, and the ability to migrate in capillary tubes. The phagocytic activity of colostral leukocytes against nonencapsulated Cryptococcus neoformans approached the normal values of peripheral blood leukocytes. The colostral leukocytes reacted to specific antigen similar to the donors' peripheral blood leukocytes and correlated with the dermal reactivity of the donor. The finding that these leukocytes are in relatively large numbers and possess phagocytic activity supports the concept that this is a naturally occurring in vivo phenomenon and that these cells may protect the breast against invading microorganisms; also, since these cells demonstrate the presence of cell-mediated hypersensitivity and are normally ingested by the neonate, they may play a role in the development and/or induction of cellular immunity in the neonate. JF - Journal of Surgical Oncology AU - Mohr, John A AU - Leu, Richard AU - Mabry, Wynn AD - Departments of Medicine and Microbiology at the University of Oklahoma Medical Center and Veterans Administration Hospital, Oklahoma City, Oklahoma Y1 - 1970 PY - 1970 DA - 1970 SP - 163 EP - 167 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 2 IS - 2 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Skin KW - Leukocytes KW - Peripheral blood KW - Hypersensitivity KW - Cryptococcus neoformans KW - Immunity (cell-mediated) KW - Phagocytes KW - Capillary tubes KW - Microorganisms KW - Colostrum KW - Neonates KW - Cell migration KW - F 06925:Hypersensitivity KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754562333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=Colostral+leukocytes&rft.au=Mohr%2C+John+A%3BLeu%2C+Richard%3BMabry%2C+Wynn&rft.aulast=Mohr&rft.aufirst=John&rft.date=1970-01-01&rft.volume=2&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930020211 L2 - http://www3.interscience.wiley.com/journal/112720611/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Skin; Immunity (cell-mediated); Phagocytes; Capillary tubes; Leukocytes; Microorganisms; Peripheral blood; Colostrum; Cell migration; Neonates; Cryptococcus neoformans DO - http://dx.doi.org/10.1002/jso.2930020211 ER - TY - JOUR T1 - TODAY'S PPBS: THE FATAL TRIUMPH OF FINANCIAL MANAGEMENT OVER ECONOMICS AN - 18976793; 7008723 AB - THE EMERGENCE OF THE GOVERNMENT AS AN ECONOMIC ENTERPRISE CALLS FOR THE DEVELOPMENT OF PROCEDURES FOR THE ECONOMIC EVALUATION OF GOVERNMENT ENTERPRISE ACTIVITIES. IN THE AREA OF WATER RESOURCES THE GOVERNMENT IS OFTEN THE LARGEST INVESTOR SO THAT A PROPER METHOD OF EVALUATION SHOULD BE OF INTEREST TO THE WATER RESEARCHER. THE AUTHOR SHOWS THAT AN ECONOMIC FORM OF PLANNING-PROGRAMMING-BUDGETING SYSTEM (PPBS) IS THE PROCEDURE NEEDED TO REPLACE THE FINANCIAL MANAGEMENT TYPE OF PPBS PRESENTLY IN USE. THE MARGINAL UTILITY THEORY OF VALUE, BECAUSE IT PROVIDES THE GOVERNMENT WITH A CONCEPTUAL BASIS UPON WHICH TO APPRAISE THE BENEFIT OF AN ENTERPRISE'S INDIVIDUAL OFFERINGS, IS ESSENTIAL TO AN ECONOMIC PPBS. APPLYING THIS THEORY CALLS FOR IDENTIFYING THE FEDERAL ENTERPRISE'S FINAL OUTPUTS AND THE CUSTOMERS WHO RECEIVE THEM. IN THE LAST SECTION THE PAPER RECOMMENDS A SPECIFIC DESIGN INCLUDING A STANDARDIZED GOVERNMENT-WIDE PROGRAM STRUCTURE AND SUBSTRUCTURE FOR THE ECONOMIC PPBS. (MURPHY-RUTGERS) JF - IN THE ANALYSIS AND EVALUATION OF PUBLIC EXPENDITURES: THE PPB SYSTEM, A COMPENDIUM OF PAPERS SUBMITTED TO THE SUBCOMMITTEE ON ECONOMY IN GOVERNMENT OF THE JOINT ECONOMIC COMMITTEE, US GOVERNMENT PRINTING OFFICE, WASHINGTON DC, 1969, VOL III P 886-898. AU - Greenhouse, Samuel M AD - VETERANS ADMINISTRATION, WASHINGTON, D.C Y1 - 1969 PY - 1969 DA - 1969 KW - Water Resources Abstracts KW - *SYSTEMS ANALYSIS KW - *ECONOMIC EVALUATION KW - *PLANNING KW - *PROGRAMMING KW - *BUDGETING KW - *GOVERNMENT KW - FORECASTING ECONOMIC ANALYSIS KW - DECISION-MAKING KW - MANAGEMENT KW - COSTS KW - BENEFITS KW - VALUE KW - PRICES KW - ECONOMIC EFFICIENCY KW - *PPBS KW - MARGINAL UTILITY KW - MARKET SYSTEM KW - EXECUTIVE BRANCH KW - OPPORTUNITY COST KW - SW 4010:Techniques of planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18976793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=TODAY%27S+PPBS%3A+THE+FATAL+TRIUMPH+OF+FINANCIAL+MANAGEMENT+OVER+ECONOMICS&rft.au=Greenhouse%2C+Samuel+M&rft.aulast=Greenhouse&rft.aufirst=Samuel&rft.date=1969-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The effect of cyclophosphamide on hematopoietic stem cells. AN - 76351207; 17387883 AB - The effects of cyclophosphamide on hematopoietic stem cells (HSC) and on hematopoiesis was studied. Administration of 5 mg of cyclophosphamide to mice resulted in a rapid decrease in the number of HSC in the leg and spleen. The exocolonizing potential of HSC in the spleen recovered and reached supranormal levels in 7 days. That of HSC in the legs recovered to pretreatment values after 15 days. The endocolonizing potential of HSC in the leg, however, recovered in less than 4 days. The peripheral blood counts all dropped to a fraction of normal except for the platelet count, which was affected to a minimal degree. We suggest that cyclophosphamide irreparably damages most of the body's HSC. Those remaining in the leg then proliferate rapidly and repopulate other sites. HSC cannot, however, accumulate in the leg for more than a week after cyclophosphamide administration. Erythropoiesis does not recover until after this occurs. Platelets are least affected because of their resistance to the effects of the drug and because of the ability of megakaryocytes to increase their output of platelets without requiring differentiation of HSC into their compartment. JF - Radiation research AU - Fried, W AU - Johnson, C AD - Department of Medicine, Veterans Administration West Side Hospital. Y1 - 1968/12// PY - 1968 DA - December 1968 SP - 521 EP - 527 VL - 36 IS - 3 SN - 0033-7587, 0033-7587 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Space life sciences KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mice KW - Cell Differentiation -- drug effects KW - Female KW - Hematopoiesis -- physiology KW - Blood Cells -- cytology KW - Hematopoiesis -- drug effects KW - Hematopoietic Stem Cells -- cytology KW - Hematopoietic Stem Cells -- physiology KW - Blood Cells -- drug effects KW - Blood Cells -- physiology KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76351207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+effect+of+cyclophosphamide+on+hematopoietic+stem+cells.&rft.au=Fried%2C+W%3BJohnson%2C+C&rft.aulast=Fried&rft.aufirst=W&rft.date=1968-12-01&rft.volume=36&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Value of chemical mixture in multiple supralethal X-irradiation of mice. AN - 76350904; 17387944 AB - A chemical mixture containing 25 Amoles of MEA, 7 pmoles of AET, and 2 micromoles of 5-HT was found to be of significant value in protecting mice against repeated exposures of 800 R, 1100 R, or 1400 R given at intervals of 28 days. Dose-reduction factors of 2.17, 2.18, 1.95, 2.14, and 1.58 were obtained for the first five exposures. Following the first exposure there was no chemical mortality. The beneficial value of this mixture, however, was limited by the incidence of chemical toxicity which was more prevalent in mice with higher cumulative doses of radiation. JF - Radiation research AU - Wang, R I AU - Hasegawa, A T AD - Veterans Administration Center, Wood, Wisconsin, USA. Y1 - 1968/11// PY - 1968 DA - November 1968 SP - 254 EP - 260 VL - 36 IS - 2 SN - 0033-7587, 0033-7587 KW - Drug Combinations KW - 0 KW - Radiation-Protective Agents KW - beta-Aminoethyl Isothiourea KW - 151-16-6 KW - Serotonin KW - 333DO1RDJY KW - Cysteamine KW - 5UX2SD1KE2 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Mice, Inbred ICR KW - Mice KW - Dose-Response Relationship, Radiation KW - Survival Analysis KW - Survival Rate KW - Radiation-Protective Agents -- administration & dosage KW - Cysteamine -- administration & dosage KW - Serotonin -- administration & dosage KW - X-Rays -- adverse effects KW - Radiation Tolerance -- drug effects KW - beta-Aminoethyl Isothiourea -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76350904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Value+of+chemical+mixture+in+multiple+supralethal+X-irradiation+of+mice.&rft.au=Wang%2C+R+I%3BHasegawa%2C+A+T&rft.aulast=Wang&rft.aufirst=R&rft.date=1968-11-01&rft.volume=36&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hematological response to isologous and homologous bone marrow transplantation: mechanism of homologous failure. AN - 76347064; 17387924 AB - C3H mice (H-2 locus = k, hemoglobin D) received marrow cells intravenously following supralethal total-body x-irradiation. Donors were C3H, AKR (k, hemoglobin D), C57BR (k, hemoglobin S), A (a, hemoglobin D), and C57BL (b, hemoglobin S). Compatible marrow recipients suffered 20 % mortality. Incompatible H-2 and hemoglobin donation resulted in 97 % (mortality by the twenty-fifth day. H-2-compatible, hemoglobin-incompatible recipients suffered 67 % mortality by the fortieth day and then no further mortality. The H-2-incompatible, hemoglobin-compatible donation resulted in 36 % mortality by the fortieth day and showed continued mortality thereafter. Peripheral blood hematocrit and granulocyte counts and bone marrow cellularity and DNase activity revealed no significant differences, demonstrating successful grafts in all groups. However, the recovery of peripheral blood lymphocytes was inversely related to the mortality. Lymphopoiesis is apparently inhibited when the transplanted lymphocytes encounter overwhelming concentration of foreign antigens in the host. The H-2-compatible, hemoglobin-incompatible graft replaces the host's erythrocytes, thereby eliminating the inhibition of the graft's lymphocytic proliferation by that host antigen. During the first 40 days, homologous deaths result primarily from the effects of lymphopenia; thereafter, with recovery of lymphopoiesis, deaths are probably due to graft versus host reaction. JF - Radiation research AU - Kurnick, N B AU - Nokay, N AD - Department of Medicine, University of California at Irvine, Long Beach Veterans Administration Hospital, Long Beach, California, USA. Y1 - 1968/10// PY - 1968 DA - October 1968 SP - 31 EP - 44 VL - 36 IS - 1 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Survival Rate KW - Treatment Outcome KW - Mice, Inbred C3H KW - Transplantation, Autologous -- methods KW - Mice KW - Transplantation, Heterologous -- methods KW - Survival Analysis KW - Hematologic Diseases -- prevention & control KW - Bone Marrow Transplantation -- methods KW - Hematologic Diseases -- etiology KW - Hematologic Diseases -- diagnosis KW - Whole-Body Irradiation -- adverse effects KW - Radiation Injuries, Experimental -- etiology KW - Radiation Injuries, Experimental -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76347064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Hematological+response+to+isologous+and+homologous+bone+marrow+transplantation%3A+mechanism+of+homologous+failure.&rft.au=Kurnick%2C+N+B%3BNokay%2C+N&rft.aulast=Kurnick&rft.aufirst=N&rft.date=1968-10-01&rft.volume=36&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic vasoconstrictor and renal vasodilator effects of PLV-2 (octapressin) in man. AN - 84768989; 11712284 AB - The systemic and renal hemodynamic effects of PLV-2 (octapressin) were studied in patients with hypotension or decompensated cirrhosis of the liver. Low doses (0.004 to 0.02 units/min) increased renal blood flow (indicator-dilution technique), reduced renal vascular resistance, and produced a slight increase in arterial pressure and systemic vascular resistance. Higher doses (0.1 to 0.5 units/min) produced a sharp increase in arterial pressure and systemic resistance while renal resistance increased moderately and renal blood flow usually was maintained above control levels. Renal fraction was increased at all dose levels. The increased renal blood flow was accompanied by more rapid intrarenal dye transit time and slight increase in renal extraction ratio of paraaminohippurate suggesting a rise in cortical blood flow. It is concluded that PLV-2 in small doses produces renal vasodilation and in larger doses preferential extra-renal vasoconstriction resulting in redistribution of blood flow to the kidney. JF - Circulation AU - Cohn, J N AU - Tristani, F E AU - Khatri, I M AD - Hypertension and Clinical Hemodynamics Section, Veterans Administration Hospital, Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA. Y1 - 1968/07// PY - 1968 DA - July 1968 SP - 151 EP - 157 VL - 38 IS - 1 SN - 0009-7322, 0009-7322 KW - Angiotensins KW - 0 KW - Vasoconstrictor Agents KW - Felypressin KW - 56-59-7 KW - Norepinephrine KW - X4W3ENH1CV KW - Abridged Index Medicus KW - Index Medicus KW - Renal Circulation -- drug effects KW - Humans KW - Angiotensins -- administration & dosage KW - Blood Pressure -- drug effects KW - Cardiac Output -- drug effects KW - Norepinephrine -- administration & dosage KW - Hypotension -- drug therapy KW - Vasodilation -- drug effects KW - Vasoconstrictor Agents -- adverse effects KW - Vasoconstrictor Agents -- administration & dosage KW - Vasoconstriction -- drug effects KW - Felypressin -- administration & dosage KW - Felypressin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/84768989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Systemic+vasoconstrictor+and+renal+vasodilator+effects+of+PLV-2+%28octapressin%29+in+man.&rft.au=Cohn%2C+J+N%3BTristani%2C+F+E%3BKhatri%2C+I+M&rft.aulast=Cohn&rft.aufirst=J&rft.date=1968-07-01&rft.volume=38&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ankle Blood Pressure Response to Graded Treadmill Exercise AN - 20077523; 10097094 JF - Angiology AU - Stahler, Christopher AU - Strandness, DE AD - Surgical Service Veterans Administration Hospital 4435 Beacon Avenue South Seattle, Washington 98108 Y1 - 1967/04// PY - 1967 DA - Apr 1967 SP - 237 EP - 241 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 18 IS - 4 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - Ankles KW - Exercise KW - Blood pressure KW - Treadmill ergometry KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20077523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Ankle+Blood+Pressure+Response+to+Graded+Treadmill+Exercise&rft.au=Stahler%2C+Christopher%3BStrandness%2C+DE&rft.aulast=Stahler&rft.aufirst=Christopher&rft.date=1967-04-01&rft.volume=18&rft.issue=4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F000331976701800406 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ankles; Exercise; Treadmill ergometry; Blood pressure DO - http://dx.doi.org/10.1177/000331976701800406 ER - TY - JOUR T1 - DETERMINATION OF COPPER AND ZINC IN BIOLOGICAL MATERIAL AN - 19102462; 7407712 AB - COPPER AND ZINC ARE READILY DETERMINED IN BIOLOGICAL MATERIAL BY ATOMIC ABSORPTION SPECTROPHOTOMETRY. TWO PROCEDURES ARE PRESENTED FOR THE QUANTITATIVE ESTIMATION OF THESE METALS IN SERUM. ONE OF THESE INVOLVES SIMPLE DILUTION AND ASPIRATION INTO THE BURNER OF THE INSTRUMENT. SUITABLY PREPARED STANDARDS MUST BE USED. THE OTHER METHOD INVOLVES TRICHLOROACETIC ACID PREPARATION OF THE PROTEINS PRIOR TO ASPIRATION. WITH BOTH METHODS SATISFACTORY RESULTS IN PRECISION AND RECOVERY OF ADDED METALS ARE OBTAINED. URINARY COPPER DETERMINATIONS REQUIRE CHELATION OF THE METAL WITH AMMONIUM PYRROLIDINO DITHIOCARBAMATE OR SOME SIMILAR SEQUESTERING AGENT AND CONCENTRATION BY EXTRACTION OF THE CHELATE INTO A SUITABLE ORGANIC SOLVENT. A SIMILAR PROCEDURE MUST BE USED IN ANALYZING COW'S MILK FOR COPPER. TISSUE ANALYSIS REQUIRES HEATING WITH BOILING NITRIC ACID AND REMOVAL OF THE ACID UNDER REDUCED PRESSURE PRIOR TO ASPIRATION INTO THE BURNER. IT HAS BEEN SHOWN THAT PROCEDURAL ERRORS IN SUCH DETERMINATIONS ARE VERY MUCH SMALLER THAN BIOLOGICAL VARIATION. (OLESZKIEWICZ-VANDERBILT) JF - CLINICAL CHEMISTRY, VOL 13, NO 1, P 40-48, JANUARY 1967. 5 TAB, 7 REF. AU - Parker, M M AU - HUMOLLER, F L AU - Mahler, D J AD - VETERANS ADMINISTRATION HOSPITAL, OMAHA, NEBR Y1 - 1967/01// PY - 1967 DA - Jan 1967 KW - Water Resources Abstracts KW - *COPPER KW - *ZINC KW - *SPECTROPHOTOMETRY KW - *POLLUTANT IDENTIFICATION KW - URINE KW - MILK KW - ANALYTICAL TECHNIQUES KW - SEPARATION TECHNIQUES KW - ANALYSIS KW - METALS KW - HEAVY METALS KW - CHELATION KW - LABORATORY TESTS KW - INSTRUMENTATION KW - *ATOMIC ABSORPTION SPECTROSCOPY KW - *BIOLOGICAL SAMPLES KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19102462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DETERMINATION+OF+COPPER+AND+ZINC+IN+BIOLOGICAL+MATERIAL&rft.au=Parker%2C+M+M%3BHUMOLLER%2C+F+L%3BMahler%2C+D+J&rft.aulast=Parker&rft.aufirst=M&rft.date=1967-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - INTEMPERANCE: PSYCHOLOGICAL AND SOCIOLOGICAL CONCOMITANTS AN - 60558456; 64B3100 AB - An investigation of 'the personality, soc & demographic characteristics of a group of patients who indicate that at times they have been intemperate (IT) (in the drinking of alcoholic beverages).' The sample was composed of 78 M's hosp'ed in a Veterans Admin hosp. S's were individually admin'ed a Biographical Data Questionaire (BDQ), the Comrey Personality Inventory & the Raven Progressive Matrices 1956 Revision, Standard Form. The group was divided on the basis of whether they had been IT or not. 'There was no significance in intelligence, age, or educ; but the temperate (T) group showed signif'ly more job & financial stability.' It was found that the IT S's scored higher on both the shyness & anxiousness factors & in a series of one-variable factors, eg, pessimism, excitability, sex concern & skepticism (IT S's were more concerned about sex & worried about being good sex partners). 'It is concluded that the Comrey Personality Inventory & the BDQ can differentiate T from IT S's in a specific SE group & give a basis for the clarification of M. Keller's operational definition of an alcoholic ie, `alcoholism is a chronic disease manifested by repeated implicative drinking so as to cause injury to the drinker's health or to his soc or econ functioning'] .' G. Jacobs. JF - Quarterly Journal of Studies on Alcohol AU - Wine, David B AU - Edwards, Allan E AD - WADSWORTH GENERAL MEDICAL & SURGICAL HOSP, VETERANS ADMINISTRATION CENTER, LOS ANGELES, CALIF Y1 - 1964/03// PY - 1964 DA - March 1964 SP - 77 EP - 84 VL - 25 IS - 1 KW - DRINKING : PSYCHOLOGICAL & SOCIOLOGICAL CHARACTERISTICS, KW - PSYCHOLOGY : CHARACTERISTICS OF DRINKING, KW - SOCIOLOGICAL : CHARACTERISTICS OF DRINKING, KW - Drinking/Drinkers KW - Sociological KW - Psychology/Psychological/ Psychologically/ Psychologism KW - article KW - 2147: social problems and social welfare; sociology of crime & victimology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60558456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quarterly+Journal+of+Studies+on+Alcohol&rft.atitle=INTEMPERANCE%3A+PSYCHOLOGICAL+AND+SOCIOLOGICAL+CONCOMITANTS&rft.au=Wine%2C+David+B%3BEdwards%2C+Allan+E&rft.aulast=Wine&rft.aufirst=David&rft.date=1964-03-01&rft.volume=25&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Quarterly+Journal+of+Studies+on+Alcohol&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - QJSOAX N1 - SubjectsTermNotLitGenreText - Drinking/Drinkers; Psychology/Psychological/ Psychologically/ Psychologism; Sociological ER - TY - JOUR T1 - APPLICATION OF HYDRODYNAMIC ANALOGS AND DIGITAL COMPUTER TO THE STUDY OF PHOSPHOLIPID KINETICS * AN - 1850776106; PQ0003923713 JF - Annals of the New York Academy of Sciences AU - Shore, Moris L AU - Callahan, Robert AD - Research Service, Wood Veterans Administration Center and Department of Physiology, Marquette University School of Medicine, Milwaukee, Wise. Y1 - 1963/05// PY - 1963 DA - May 1963 SP - 147 EP - 171 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 108 IS - 1 SN - 0077-8923, 0077-8923 KW - Immunology Abstracts; Environment Abstracts KW - Hydrodynamics KW - Kinetics KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850776106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=APPLICATION+OF+HYDRODYNAMIC+ANALOGS+AND+DIGITAL+COMPUTER+TO+THE+STUDY+OF+PHOSPHOLIPID+KINETICS+*&rft.au=Shore%2C+Moris+L%3BCallahan%2C+Robert&rft.aulast=Shore&rft.aufirst=Moris&rft.date=1963-05-01&rft.volume=108&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.1963.tb13371.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Hydrodynamics; Kinetics DO - http://dx.doi.org/10.1111/j.1749-6632.1963.tb13371.x ER - TY - JOUR T1 - BELIEFS ABOUT MENTAL ILLNESS AS A FUNCTION OF PSYCHIATRIC STATUS AND PSYCHIATRIC HOSPITALIZATION AN - 60574777; 65B5652 AB - Beliefs about mental illness (MI) were assessed among psychiatric inpatients at a VA hosp, the mental health staff responsible for their treatment, & a group of Med & surgical (control) patients. Results indicated that: (a) Psychiatric & nonpsychiatric patients generally hold similar opinions re MI. Severely disturbed psychiatric patients, however, view MI in more moralistic terms than do 'normals'. (b) Psychiatric hosp'tion is generally accompanied by a change in the patient's beliefs concerning MI, toward those held by the staff. (c) Psychiatric patients whose beliefs about MI are most strikingly influenced by the staff tend to respond most favorably to treatment, as measured by length of hospital stay & gains in self-esteem during the 1st month of treatment. AA. JF - Journal of Abnormal and Social Psychology AU - Manis, Melvin AU - Houts, Peter S AU - Blake, Joan B AD - U OF MICHIGAN & VETERANS ADMINISTRATION HOSPITAL, ANN ARBOR Y1 - 1963///0, PY - 1963 DA - 0, 1963 SP - 226 EP - 233 VL - 67 IS - 3 KW - BELIEF : ABOUT MENTAL ILLNESS, KW - MENTAL ILLNESS : BELIEFS ABOUT, KW - PSYCHIATRY : PATIENTS' BELIEFS ABOUT MENTAL ILLNESS, KW - Psychiatry/Psychiatric KW - Belief/Beliefs KW - Mental illness/Mentally ill KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60574777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+and+Social+Psychology&rft.atitle=BELIEFS+ABOUT+MENTAL+ILLNESS+AS+A+FUNCTION+OF+PSYCHIATRIC+STATUS+AND+PSYCHIATRIC+HOSPITALIZATION&rft.au=Manis%2C+Melvin%3BHouts%2C+Peter+S%3BBlake%2C+Joan+B&rft.aulast=Manis&rft.aufirst=Melvin&rft.date=1963-01-01&rft.volume=67&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+and+Social+Psychology&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Belief/Beliefs; Mental illness/Mentally ill; Psychiatry/Psychiatric ER - TY - JOUR T1 - PSYCHOPATHY AND CRIMINALITY AN - 60547842; 64B0713 AB - A reply to an article by M. Schmideberg (see SA 2046-B0680) on the psychopath (PS) & his soc values. 2 broad criticisms are voiced: (1) that only the `skilled' PS is identified as such (referring to ideological & linguistic skill, used for self-justification), whereas not all PS's possess such `skill,' & (2) Schmideberg's tendency to equate criminality with psychopathy; ie, in comparing US & European felony ratios. It is agreed that the PS is characterized by `profound egocentrism,' but it is asserted that most crime is not psychopathic, & that most criminals, unlike the PS, have some dependable loyalties & are not wholly egocentric. It is stated that 'soc disorg usually recognizes an in-group & an out-group, & the dictates of morality always operate more strongly towards members of the in-group. This is [also] a basis of ethnocentrism & of prejudice. [ Nonidentification] is as characteristic of prejudice as it is of psychopathy.' It is thought that the nonPS offender (ie, one with dependable loyalties) should be helped to see how these loyalties can be used in constructive ways. The importance of using loyalties as an effective treatment tool is emphasized. J. Atkins. JF - International Journal of Offender Therapy and Comparative Criminology AU - JENKINS, RICHARD LEOS AD - VETERANS' ADMINISTRATION HOSP, WASHINGTON, DC Y1 - 1962/09// PY - 1962 DA - September 1962 SP - 27 EP - 29 VL - 6 IS - 2 SN - 0306-624X, 0306-624X KW - CRIMINAL : & PSYCHOPATHY, KW - PSYCHOPATH : & CRIMINALITY, KW - VALUE : SOCIAL, OF CRIMINAL, KW - Criminal/Criminals/Criminality/Criminally (see also Crime) KW - Psychopath/Psychopathic/ Psychopathy/ Psychopathology/ Psychopathological KW - Value/Values/Valuation/ Valuations KW - article KW - 2147: social problems and social welfare; sociology of crime & victimology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60547842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Offender+Therapy+and+Comparative+Criminology&rft.atitle=PSYCHOPATHY+AND+CRIMINALITY&rft.au=JENKINS%2C+RICHARD+LEOS&rft.aulast=JENKINS&rft.aufirst=RICHARD&rft.date=1962-09-01&rft.volume=6&rft.issue=2&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Offender+Therapy+and+Comparative+Criminology&rft.issn=0306624X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IOTCAH N1 - SubjectsTermNotLitGenreText - Criminal/Criminals/Criminality/Criminally (see also Crime); Psychopath/Psychopathic/ Psychopathy/ Psychopathology/ Psychopathological; Value/Values/Valuation/ Valuations ER - TY - JOUR T1 - It's Time to Start Counting AN - 20169059; 10221110 AB - Six pieces of evidence are presented to advocate the use of prediction procedures as a means of studying the effectiveness of any correctional agency's decisions and operations. It is main tained that (1) experience is not enough, and systematic self- study is essential to correctional effectiveness; (2) correctional agencies are spending too much money for too little return; (3) prediction devices do hold up; (4) correctional programs help some offenders but probably harm others; (5) correctional agencies waste programs on "good risks"; and (6) subjective de cisions as well as statistical formulas need study. Prediction procedures are advocated as aids in making correctional evalua tions and in developing appropriate classification systems.[/italic JF - Crime and Delinquency AU - Grant, JDouglas AD - Research Division, California Department of Corrections, Office of Naval Research, Rehabilitation Research, U.S. Naval Retraining Command, Veterans Administration, San Jose Juvenile Court, Stanford University Y1 - 1962/07// PY - 1962 DA - Jul 1962 SP - 259 EP - 264 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 8 IS - 3 SN - 0011-1287, 0011-1287 KW - Risk Abstracts KW - delinquency KW - crime KW - classification KW - R2 23100:Sociological factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20169059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Crime+and+Delinquency&rft.atitle=It%27s+Time+to+Start+Counting&rft.au=Grant%2C+JDouglas&rft.aulast=Grant&rft.aufirst=JDouglas&rft.date=1962-07-01&rft.volume=8&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Crime+and+Delinquency&rft.issn=00111287&rft_id=info:doi/10.1177%2F001112876200800304 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - delinquency; crime; classification DO - http://dx.doi.org/10.1177/001112876200800304 ER - TY - JOUR T1 - ROLE REVERSAL AND CONFLICT BETWEEN AGED PARENTS AND THEIR CHILDREN AN - 60554031; 63A5003 AB - An attempt to explore some of the sociol'al facets of personal problems of 120 aged Jewish clients who requested help at a soc agency in a large metropolitan area. The study pop consisted of all cases handled by the agency's Department of Services to the Aging, in which there was a request for service between Jan 1958 through Jun, 1959. Data gathered from process records, summary records & the face sheet for each case were placed on a schedule, which was then used for statistical analysis. The findings are consistent with other studies which suggest that SC diff's between parents & children are not responsible for the personal problems of the aged. The modern US fam fits neither the stereotype of the classical extended fam nor that of the isolated nuclear fam. While parents & children are expected to maintain close psychol'al & emotional ties, children are not expected to provide material support for their aged parents, esp if this may disturb the independence of their own conjugal fam group. Since society has not yet provided adequately for the health & welfare needs of our aged, there is a gap between the expectation & reality, leading to role conflict among parents & children, & personal troubles. Changing societal norms have also pushed many of the aged into dependency roles in their fam of procreation, a reversal of the roles they played with their own children, intensifying conflicts which may already be present. The findings of this study are meant to be only suggestive. The distinctive pop & small sample considerably limits generalization. AA. JF - Marriage and Family Living AU - Glasser, Paul H AU - Glasser, Lois N AD - U OF MICHIGAN, & VETERANS ADMINISTRATION HOSP, ANN ARBOR Y1 - 1962/02// PY - 1962 DA - February 1962 SP - 46 EP - 50 VL - 24 IS - 1 SN - 0022-2445, 0022-2445 KW - AGING-AGED : JEWS, PERSONAL PROBLEMS OF, KW - AGING-AGED : PARENTS & THEIR CHILDREN, CONFLICT BETWEEN & ROLE REVERSAL, KW - CHILD : & AGED PARENTS, CONFLICT BETWEEN & ROLE REVERSAL, KW - CONFLICT : BETWEEN AGED PARENTS & THEIR CHILDREN& ROLE REVERSAL, KW - JEW : AGED, PERSONAL PROBLEMS OF, KW - PARENT : AGED & THEIR CHILDREN, CONFLICT BETWEEN & ROLE REVERSAL, KW - ROLE : REVERSAL & CONFLICT BETWEEN AGED PARENTS & THEIR CHILDREN, KW - Aging (see also Aged, Geriatric) KW - Role/Roles KW - Child/Children/Childhood KW - Jew/Jews/Jewry/Jewish (see also Judaism) KW - Conflict/Conflicts KW - Parent/Parents/Parental KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60554031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marriage+and+Family+Living&rft.atitle=ROLE+REVERSAL+AND+CONFLICT+BETWEEN+AGED+PARENTS+AND+THEIR+CHILDREN&rft.au=Glasser%2C+Paul+H%3BGlasser%2C+Lois+N&rft.aulast=Glasser&rft.aufirst=Paul&rft.date=1962-02-01&rft.volume=24&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Marriage+and+Family+Living&rft.issn=00222445&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Aging (see also Aged, Geriatric); Child/Children/Childhood; Conflict/Conflicts; Jew/Jews/Jewry/Jewish (see also Judaism); Parent/Parents/Parental; Role/Roles ER - TY - JOUR T1 - DOGMATISM AND ACQUIESCENT RESPONSE SET AN - 60548695; 63A4462 AB - A study of 40 adult M neuropsychiatric inpatients to test the hypothesis that the Rokeach Dogmatism scale 'is just as vulnerable to acquiescent response set as the F Scale.' 2 measures of acquiescence were developed & administered along with the Dogmatism & F Scales & a measure of verbal intelligence. Results indicate that both measures of acquiescence were positively related to the Dogmatism & F Scales. It is suggested therefore that 'previous work with Dogmatism should be reexamined with an eye to determining which measures are related to Dogmatism by virtue of their sharing variance in acquiescence.' I. Taviss. JF - Journal of Abnormal and Social Psychology AU - Lichtenstein, Edward AU - Quinn, Robert P AU - Hover, Gerald L AD - U OF MICHIGAN & VETERANS ADMINISTRATION HOSP, ANN ARBOR Y1 - 1961/11// PY - 1961 DA - November 1961 SP - 636 EP - 638 VL - 63 IS - 3 KW - ACQUIESCENCE : RESPONSE SET, DOGMATISM, KW - DOGMATISM : & ACQUIESCENT RESPONSE SET, KW - RESPONSE : SET, DOGMATISM & ACQUIESCENT, KW - SET : DOGMATISM & ACQUIESCENT RESPONSE, KW - Set/Sets/Settings KW - Response/Responsive/ Responsiveness/Responses KW - Acquiescence KW - Dogma/Dogmas/Dogmatic/Dogmatism KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60548695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+and+Social+Psychology&rft.atitle=DOGMATISM+AND+ACQUIESCENT+RESPONSE+SET&rft.au=Lichtenstein%2C+Edward%3BQuinn%2C+Robert+P%3BHover%2C+Gerald+L&rft.aulast=Lichtenstein&rft.aufirst=Edward&rft.date=1961-11-01&rft.volume=63&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+and+Social+Psychology&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquiescence; Dogma/Dogmas/Dogmatic/Dogmatism; Response/Responsive/ Responsiveness/Responses; Set/Sets/Settings ER - TY - JOUR T1 - Protecting Veterans from "Fake Schools" AN - 1300536081 JF - Occupations AU - Veterans Administration AD - Veterans Administration Y1 - 1945/12/01/ PY - 1945 DA - 1945 Dec 01 SP - 137 CY - Alexandria, Va. PB - American Association for Counseling and Development. VL - 24 IS - 3 KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1300536081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apio&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupations&rft.atitle=Protecting+Veterans+from+%22Fake+Schools%22&rft.au=Veterans+Administration&rft.aulast=Veterans+Administration&rft.aufirst=&rft.date=1945-12-01&rft.volume=24&rft.issue=3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Occupations&rft.issn=&rft_id=info:doi/ DB - Periodicals Index Online N1 - Last updated - 2013-02-24 ER - TY - JOUR T1 - Colleges Cooperate with Veterans Administration AN - 1300534936 JF - Occupations AU - Veterans Administration AD - Veterans Administration Y1 - 1945/03/01/ PY - 1945 DA - 1945 Mar 01 SP - 317 CY - Alexandria, Va. PB - American Association for Counseling and Development. VL - 23 IS - 6 KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1300534936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apio&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupations&rft.atitle=Colleges+Cooperate+with+Veterans+Administration&rft.au=Veterans+Administration&rft.aulast=Veterans+Administration&rft.aufirst=&rft.date=1945-03-01&rft.volume=23&rft.issue=6&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Occupations&rft.issn=&rft_id=info:doi/ DB - Periodicals Index Online N1 - Last updated - 2013-02-24 ER - TY - GEN T1 - Title Some observations on the nature of the audiometric 4000 hz notch: data from 3430 veterans. AN - 871374711; pmid-Accession Number 21419067 AB - Abstract Pure-tone, air-conduction audiograms notched at 4000 Hz have long been considered the signature configuration for noise-induced hearing loss even though there is an extensive literature that does not mesh with this simple explanation. There are many reports of notched audiograms from individuals with no history of noise exposure and, conversely, reports of audiograms with no notches from individuals with a history of noise exposure. Recent reports increasingly suggest that unilateral 4000 Hz notches are common. The prevalence of notched audiograms at 4000 Hz is dependent on the definition of the notch and the population under study.To examine the prevalence and characteristics of audiograms that are notched at 4000 Hz.Retrospective, descriptive.The participants were 3430 veterans evaluated in the Audiology Clinic at the VA Medical Center, Mountain Home, Tennessee. The mean age was 62.3 yr. Data Collection and Analyses: The data were collected in the course of a 60 min, routine audiological evaluation. In addition to pure-tone audiometry, a history, otoscopy, speech audiometry in quiet and in noise, and aural-acoustic immittance measures were included in the clinic protocol but were not evaluated in this report. A notch was defined when the 4000 Hz threshold minus the 2000 Hz threshold and the 4000 Hz threshold minus the 8000 Hz threshold both were ≥10 dB.Overall the mean LE (left ear) thresholds at 2000, 3000, and 4000 Hz were at hearing levels 2-3 dB higher than the hearing levels for the corresponding mean RE (right ear) thresholds; the differences were significant. A notched audiogram was observed in 40.6% of the participants in at least one ear with 15.4% having bilateral notches, 28.8% LE notches, and 27.1% RE notches. Unilateral 4000 Hz notches were almost twice as prevalent as bilateral 4000 Hz notches. Viewed as a function of age, notched audiograms were most common (∼35% of the participants) in the 40 and 50 yr groups with a diminishing prevalence in the 60-80 yr groups. The mean notch depth at 4000 Hz was consistently 20-26 dB across the seven age groups. In comparison to the thresholds of the audiograms that were not notched, the thresholds of the audiograms with 4000 Hz notches (1) at 250-2000 Hz were at hearing levels 2-3 dB lower, (2) at 3000 and 4000 Hz were at hearing levels 8-17 dB higher, and (3) at 8000 Hz were at hearing levels 3-4 dB lower; the threshold differences were significant at all frequencies for both ears.The data suggest that unilateral, 4000 Hz notched audiograms are as common or more common than bilateral notched audiograms and that unilateral notched audiograms are equally common for the LE and RE. The prevalence and characteristics of 4000 Hz notched audiograms in this veteran sample are similar to those observed in the population as a whole.American Academy of Audiology. JF - Journal Name Journal of the American Academy of Audiology AU - Author Wilson, Richard H AD - Affiliation James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@va.gov SP - Journal Pages 23 EP - 33 VL - Journal Volume 22 IS - Journal Issue 1 KW - Subfile Index Medicus KW - Record Owner National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871374711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+Name+Journal+of+the+American+Academy+of+Audiology&rft.atitle=Title+Some+observations+on+the+nature+of+the+audiometric+4000%C2%A0hz+notch%3A+data+from+3430+veterans.&rft.au=Author+Wilson%2C+Richard+H&rft.aulast=Author+Wilson&rft.aufirst=Richard&rft.date=&rft.volume=Journal+Volume+22&rft.issue=Journal+Issue+1&rft.spage=First+Page+23&rft.isbn=&rft.btitle=&rft.title=Journal+Name+Journal+of+the+American+Academy+of+Audiology&rft.issn=ISSN&rft_id=info:doi/ LA - Language English (eng) DB - ComDisDome N1 - Last updated - 2011-09-13 ER - TY - CPAPER T1 - Pulmonary vascular changes in 33 adults with isolated atrial septal defects AN - 39791428; 3862814 AU - Sahin, AN AU - Moore, G W AU - Hutchins, G M KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39791428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+vascular+changes+in+33+adults+with+isolated+atrial+septal+defects&rft.au=Sahin%2C+AN%3BMoore%2C+G+W%3BHutchins%2C+G+M&rft.aulast=Sahin&rft.aufirst=AN&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: US and Canadian Acad. of Pathology, 3643 Walton Way Extension, Augusta, GA 30909, USA; phone: (706) 733-7550; fax: (706) 733-8033; email: IAP@uscap.org; URL: www.uscap.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Transferable Capacity for Gastrointestinal Colonization in Enterococcus faecium in a Mouse Model AN - 20328285; 9013501 AB - A high level of gastrointestinal colonization frequently precedes invasive infection due to Enterococcus faecium. Factors other than antimicrobial resistance that promote gastrointestinal colonization by E. faecium have not been identified. We tested the ability of a colonization- proficient clinical E. faecium isolate (C68) to transfer colonizing ability to noncolonizing E. faecium recipient strains. Transconjugants derived from matings that used E. faecium D344SRF as a recipient strain colonized mouse gastrointestinal tracts in high numbers under selective pressure from clindamycin or vancomycin, compared with control strains that lacked DNA transferred from C68. We transferred DNA into a second recipient strain (E. faecium GE-1), which also colonized mice in significantly greater numbers under selective pressure from clindamycin, compared with a control strain. These results indicate that E. faecium clinical isolates express transmissible factors other than antimicrobial resistance that promote colonization of the mouse gastrointestinal tract. JF - Journal of Infectious Diseases AU - Rice, Louis B AU - Lakticova, Viera AU - Carias, Lenore L AU - Rudin, Susan AU - Hutton, Rebecca AU - Marshall, Steven H AD - Medical and Research Services, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, louis.rice@va.gov SP - 342 EP - 349 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 3 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Colonization KW - Mating KW - Clindamycin KW - Drug resistance KW - Animal models KW - DNA KW - Vancomycin KW - Gastrointestinal tract KW - Infection KW - Enterococcus faecium KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20328285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Transferable+Capacity+for+Gastrointestinal+Colonization+in+Enterococcus+faecium+in+a+Mouse+Model&rft.au=Rice%2C+Louis+B%3BLakticova%2C+Viera%3BCarias%2C+Lenore+L%3BRudin%2C+Susan%3BHutton%2C+Rebecca%3BMarshall%2C+Steven+H&rft.aulast=Rice&rft.aufirst=Louis&rft.date=&rft.volume=199&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Mating; Colonization; Clindamycin; Drug resistance; DNA; Animal models; Vancomycin; Gastrointestinal tract; Infection; Enterococcus faecium ER - TY - CPAPER T1 - Maternal methyl-donor supplementation protects against atherosclerosis in F1 ApoE-/- mice T2 - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AN - 1504726287; 6265106 JF - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AU - Yung, Raymond AU - Delanaey, Colin AU - Garg, Sanjay AU - Fernandes, Christopher AU - Allen, Robert AU - Stabler, Sally KW - Mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504726287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.atitle=Maternal+methyl-donor+supplementation+protects+against+atherosclerosis+in+F1+ApoE-%2F-+mice&rft.au=Yung%2C+Raymond%3BDelanaey%2C+Colin%3BGarg%2C+Sanjay%3BFernandes%2C+Christopher%3BAllen%2C+Robert%3BStabler%2C+Sally&rft.aulast=Yung&rft.aufirst=Raymond&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jimmunol.org/content/vol190/1ULMeetingAbstracts LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER -